PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2556391-2	1989	Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH).	Proline	99-102	gonadotropin releasing hormone 1	Homo sapiens	27-57
2556391-2	1989	Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH).	Proline	99-102	gonadotropin releasing hormone 1	Homo sapiens	59-63
2558730-0	1989	Replacement of a conserved proline and the alkaline conformational change in iso-2-cytochrome c.	Proline	27-34	cytochrome c, somatic	Equus caballus	83-95
2512329-1	1989	Naturally occurring substitutions of proline residues affect plasma concentration of apolipoprotein A-I.	Proline	37-44	apolipoprotein A1	Homo sapiens	85-103
2512329-11	1989	This suggests that the interspecies conserved proline residue in position 3 of mature apo A-I is functionally important for the regular enzymatic conversion of proapo A-I to mature apo A-I.	Proline	46-53	apolipoprotein A1	Homo sapiens	86-93
2512329-11	1989	This suggests that the interspecies conserved proline residue in position 3 of mature apo A-I is functionally important for the regular enzymatic conversion of proapo A-I to mature apo A-I.	Proline	46-53	apolipoprotein A1	Homo sapiens	163-170
2511440-2	1989	The proline-rich, hydrophilic otu protein is novel.	Proline	4-11	ovarian tumor	Drosophila melanogaster	30-33
2479685-2	1989	N-terminal amino acids 1-107 of CD7 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain of CD7 is proline-rich and has been postulated to form a stalk from which the Ig domain projects.	Proline	154-161	CD7 molecule	Homo sapiens	147-150
2590215-1	1989	Proline-rich protein (PRP) is a plasma protein with a high proportion of proline residues and possessing lipid-binding properties.	Proline	73-80	complement component 4 binding protein alpha	Homo sapiens	0-20
2590215-1	1989	Proline-rich protein (PRP) is a plasma protein with a high proportion of proline residues and possessing lipid-binding properties.	Proline	73-80	complement component 4 binding protein alpha	Homo sapiens	22-25
2790799-0	1989	Proline-dependent expression of aryl hydrocarbon hydroxylase in C57BL/6 mouse hepatocytes in primary culture.	Proline	0-7	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	32-60
2687114-1	1989	The complete nucleotide (nt) sequence of the PUT4 gene, whose product is required for high-affinity proline active transport in the yeast Saccharomyces cerevisiae, is presented.	Proline	100-107	proline permease PUT4	Saccharomyces cerevisiae S288C	45-49
2688744-10	1989	Analysis of the cholesterol esterase structure also revealed a repetitive sequence enriched with Pro, Asp, Glu, Ser, and Thr residues at the C-terminal end of the protein.	Proline	97-100	carboxyl ester lipase	Rattus norvegicus	16-36
2597140-5	1989	Nevertheless, Chondrus crispus flavodoxin stands apart in a number of respects, in particular the possession of an unusually high content of proline, with these residues distributed more or less regularly along the peptide chain.	Proline	141-148	CHC_T00009139001	Chondrus crispus	31-41
2790799-6	1989	While increased amounts of P450 mRNA in C57BL/6 cells cultivated in DMEM were transient and decreased after a peak observed at 24 h, levels of mRNA in Waymouth continued to demonstrate an increase at 48 h. Addition of proline to mouse hepatocytes in DMEM increased the generation of transcripts without, however, influencing the decrease observed from 24 h to 48 h. Timing of treatment with benz(a)anthracene and incubation in Waymouth greatly influenced the eventual AHH activity.	Proline	218-225	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	468-471
2790799-8	1989	These observations suggest that induction of AHH in mouse hepatocytes is regulated by both transcriptional and posttranscriptional events and that proline-dependent events are required for expression of the enzyme activity.	Proline	147-154	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	45-48
2636901-2	1989	As part of an on-going effort to define and locate the binding sites for these and the other ligands of HRG, the sequence: NH2-Gly-His-Phe-Pro-Phe-His-Trp-... was found in a 16 kDa heme-binding peptide isolated from HRG.	Proline	139-142	histidine-rich glycoprotein	Oryctolagus cuniculus	104-107
2479544-5	1989	The threonine to proline mutation located within the second transmembranal alpha-helix might induce a conformational change and thereby prohibit the integration of PLP into the membrane with the clinical manifestation of dysmyelination leading to premature death within 3-6 weeks.	Proline	17-24	proteolipid protein 1	Rattus norvegicus	164-167
2636901-2	1989	As part of an on-going effort to define and locate the binding sites for these and the other ligands of HRG, the sequence: NH2-Gly-His-Phe-Pro-Phe-His-Trp-... was found in a 16 kDa heme-binding peptide isolated from HRG.	Proline	139-142	histidine-rich glycoprotein	Oryctolagus cuniculus	216-219
2689862-0	1989	The Saccharomyces cerevisiae PUT3 activator protein associates with proline-specific upstream activation sequences.	Proline	68-75	Put3p	Saccharomyces cerevisiae S288C	29-33
2689862-1	1989	The PUT1 and PUT2 genes encoding the enzymes of the proline utilization pathway of Saccharomyces cerevisiae are induced by proline and activated by the product of the PUT3 gene.	Proline	52-59	proline dehydrogenase	Saccharomyces cerevisiae S288C	4-8
2689861-1	1989	The enzymes of the proline utilization pathway (the products of the PUT1 and PUT2 genes) in Saccharomyces cerevisiae are coordinately regulated by proline and the PUT3 transcriptional activator.	Proline	19-26	proline dehydrogenase	Saccharomyces cerevisiae S288C	68-72
2689861-1	1989	The enzymes of the proline utilization pathway (the products of the PUT1 and PUT2 genes) in Saccharomyces cerevisiae are coordinately regulated by proline and the PUT3 transcriptional activator.	Proline	19-26	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	77-81
2689862-1	1989	The PUT1 and PUT2 genes encoding the enzymes of the proline utilization pathway of Saccharomyces cerevisiae are induced by proline and activated by the product of the PUT3 gene.	Proline	52-59	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	13-17
2689861-1	1989	The enzymes of the proline utilization pathway (the products of the PUT1 and PUT2 genes) in Saccharomyces cerevisiae are coordinately regulated by proline and the PUT3 transcriptional activator.	Proline	19-26	Put3p	Saccharomyces cerevisiae S288C	163-167
2689861-1	1989	The enzymes of the proline utilization pathway (the products of the PUT1 and PUT2 genes) in Saccharomyces cerevisiae are coordinately regulated by proline and the PUT3 transcriptional activator.	Proline	147-154	proline dehydrogenase	Saccharomyces cerevisiae S288C	68-72
2689862-1	1989	The PUT1 and PUT2 genes encoding the enzymes of the proline utilization pathway of Saccharomyces cerevisiae are induced by proline and activated by the product of the PUT3 gene.	Proline	52-59	Put3p	Saccharomyces cerevisiae S288C	167-171
2689861-1	1989	The enzymes of the proline utilization pathway (the products of the PUT1 and PUT2 genes) in Saccharomyces cerevisiae are coordinately regulated by proline and the PUT3 transcriptional activator.	Proline	147-154	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	77-81
2689862-1	1989	The PUT1 and PUT2 genes encoding the enzymes of the proline utilization pathway of Saccharomyces cerevisiae are induced by proline and activated by the product of the PUT3 gene.	Proline	123-130	proline dehydrogenase	Saccharomyces cerevisiae S288C	4-8
2689862-1	1989	The PUT1 and PUT2 genes encoding the enzymes of the proline utilization pathway of Saccharomyces cerevisiae are induced by proline and activated by the product of the PUT3 gene.	Proline	123-130	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	13-17
2685549-1	1989	To evaluate the role of exon domains in tRNA splicing, the anti-codon stem of proline pre-tRNAUGG from Saccharomyces cerevisiae was altered by site-directed mutagenesis of the suf8 gene.	Proline	78-85	SUF8	Saccharomyces cerevisiae S288C	176-180
2555519-6	1989	However, sequence homologies of the CDR2 regions of all the antibodies indicate that residues Glu H-50, Ile H-51, Pro H-52a and Tyr H-59 are conserved, and that these segments may be more critically involved in binding than the other H and L-chain hypervariable regions.	Proline	114-117	cerebellar degeneration-related 2	Mus musculus	36-40
2586513-6	1989	Analysis of the inferred 1,859-residue ama-1 product showed considerable identity with the largest subunit of RNAP II from other organisms, including the presence of a zinc finger motif near the amino terminus, and a carboxyl-terminal domain of 42 tandemly reiterated heptamers with the consensus Tyr Ser Pro Thr Ser Pro Ser.	Proline	305-308	DNA-directed RNA polymerase II subunit RPB1	Caenorhabditis elegans	39-44
2694588-5	1989	Slower migration of p27rex, corresponding to a 27-kD protein, in NaDodSO4-PAGE when compared with the calculated molecular weight from the amino acid sequence (Mr = 20,367) is suggested to be caused not by post-translational modification, but by the intrinsic nature of the protein, which is rich in proline and arginine.	Proline	300-307	interferon alpha inducible protein 27	Homo sapiens	20-23
2509008-7	1989	The calcitonin-fluoride combinations had proportional effects on net [3H]-proline incorporation and alkaline phosphatase in the treated mouse calvaria (r = 0.78, P less than 0.005).	Proline	74-81	calcitonin related polypeptide alpha	Homo sapiens	4-14
2693157-6	1989	Thus, the two derivatives specifically modified the cellular processing of insulin in cultured fetal hepatocytes, and exerted an insulin-like effect on glycogenesis clearly enhanced through modification of DP-432 by substitution of glycine for proline (DP-640).	Proline	244-251	insulin	Homo sapiens	129-136
2673039-4	1989	The expressed glutathione S-transferase protein begins with the third codon (Met) of the cDNA, and is missing the N-terminal proline of rat liver glutathione S-transferase 3-3.	Proline	125-132	hematopoietic prostaglandin D synthase	Rattus norvegicus	14-39
2813370-9	1989	A second C----T transition represented a polymorphism in proline-175 (CCC----CCT).	Proline	57-64	t-complex 1	Bos taurus	77-80
2636027-4	1989	In contrast, the activity of amino acid transport through Systems A and ASC, as assessed by the uptake of proline and serine, respectively, decreased as a function of cell density.	Proline	106-113	PYD and CARD domain containing	Homo sapiens	58-75
2773936-5	1989	The PLP gene in one of two affected males and the carrier mother of this family exhibited a single base difference in the more than 2 kb of the PLP gene sequenced, a C----T transition that would create a serine substitution for proline at the carboxy end of the protein.	Proline	228-235	proteolipid protein 1	Homo sapiens	4-7
2773936-5	1989	The PLP gene in one of two affected males and the carrier mother of this family exhibited a single base difference in the more than 2 kb of the PLP gene sequenced, a C----T transition that would create a serine substitution for proline at the carboxy end of the protein.	Proline	228-235	proteolipid protein 1	Homo sapiens	144-147
2673039-13	1989	We conclude that the first amino acid proline of glutathione S-transferase 3-3 is not essential for enzyme activities.	Proline	38-45	hematopoietic prostaglandin D synthase	Rattus norvegicus	49-74
2475572-4	1989	The peak TGF-beta levels preceded the maximum collagen and noncollagen protein synthesis measured by [3H]proline incorporation into lung fibroblast explants of bleomycin-treated rats.	Proline	105-112	transforming growth factor, beta 1	Rattus norvegicus	9-17
2527642-4	1989	Molecular weight determination of the endogenous immunoreactive peptides measured in plasma by G-50 Sephadex gel permeation chromatography revealed that the pro-ANF 1-30 radioimmunoassay recognized a peptide of 10,000 MW, which is consistent with it measuring the whole N-terminus of pro-ANF (amino acids 1-98) but without ANF (C-terminus) attached to it.	Proline	157-160	natriuretic peptide A	Homo sapiens	161-164
2527642-4	1989	Molecular weight determination of the endogenous immunoreactive peptides measured in plasma by G-50 Sephadex gel permeation chromatography revealed that the pro-ANF 1-30 radioimmunoassay recognized a peptide of 10,000 MW, which is consistent with it measuring the whole N-terminus of pro-ANF (amino acids 1-98) but without ANF (C-terminus) attached to it.	Proline	157-160	natriuretic peptide A	Homo sapiens	288-291
2527642-4	1989	Molecular weight determination of the endogenous immunoreactive peptides measured in plasma by G-50 Sephadex gel permeation chromatography revealed that the pro-ANF 1-30 radioimmunoassay recognized a peptide of 10,000 MW, which is consistent with it measuring the whole N-terminus of pro-ANF (amino acids 1-98) but without ANF (C-terminus) attached to it.	Proline	157-160	natriuretic peptide A	Homo sapiens	288-291
2508631-4	1989	This approach is illustrated by a study of the suicide inactivation of tyrosinase by catechol in the presence of L-proline.	Proline	113-122	tyrosinase	Homo sapiens	71-81
2479553-0	1989	A leucine-to-proline mutation in the insulin receptor in a family with insulin resistance.	Proline	13-20	insulin receptor	Homo sapiens	37-53
2479553-0	1989	A leucine-to-proline mutation in the insulin receptor in a family with insulin resistance.	Proline	13-20	insulin	Homo sapiens	37-44
2479553-10	1989	These observations show a linkage between the leucine-to-proline mutation and the observed insulin resistance in this family.	Proline	57-64	insulin	Homo sapiens	91-98
2668284-6	1989	However, the replacement of the activation peptide with an 8-residue sequence (Pro-Arg-Pro-Ser-Arg-Lys-Arg-Arg) involved in the proteolytic processing of the human insulin receptor precursor resulted in the direct expression of fully activated protein C.	Proline	79-82	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	244-253
2504497-0	1989	The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain.	Proline	4-11	nuclear factor I C	Homo sapiens	46-49
2504497-0	1989	The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain.	Proline	4-11	nuclear factor I C	Homo sapiens	50-54
2504497-5	1989	The CTF C-terminal region consists of an unusual type of transcriptional activation domain containing approximately 25% proline residues.	Proline	120-127	nuclear factor I C	Homo sapiens	4-7
2520246-1	1989	Fast-atom bombardment mass spectrometry of a synthetic renin substrate decapeptide (Pro-His-Pro-Phe-His-Leu-Val-Ile-His-D-Lys) indicated the presence of several side-products, including a component 12 Da higher in mass.	Proline	84-87	renin	Homo sapiens	55-60
2807732-6	1989	They include a beta turn with proline in position i + 1 and asparagine in position i + 2.	Proline	30-37	amyloid beta precursor protein	Homo sapiens	13-19
2753984-1	1989	Pyrroline-5-carboxylate (P5C) is the oxidized metabolite of proline.	Proline	60-67	pyrroline-5-carboxylate reductase 1	Homo sapiens	25-28
2507457-1	1989	In an effort to synthesize potent vasopressin analogs containing photoreactive groups, we prepared, by solid phase synthesis, three analogs with proline or hydroxyproline substitutions in positions 4 and/or 7, lysine in positions 4 or 8, and beta-mercaptopropionic acid in position 1.	Proline	145-152	arginine vasopressin	Rattus norvegicus	34-45
2752051-7	1989	The peptide bonds between pGlu-1, Pro-2 and Pro-3 are predominantly in trans-configuration, in fact no cis-isomers can be observed spectroscopically.	Proline	34-37	pyrroline-5-carboxylate reductase 1	Homo sapiens	44-49
2676726-0	1989	A human tRNA gene heterocluster encoding threonine, proline and valine tRNAs.	Proline	52-59	mitochondrially encoded tRNA glycine	Homo sapiens	8-12
2500333-2	1989	Within secretory granules, TRH-Gly is converted to TRH through alpha-amidation of the C-terminal proline residue, using Gly as the NH2 donor.	Proline	97-104	thyrotropin releasing hormone	Rattus norvegicus	27-30
2500333-2	1989	Within secretory granules, TRH-Gly is converted to TRH through alpha-amidation of the C-terminal proline residue, using Gly as the NH2 donor.	Proline	97-104	thyrotropin releasing hormone	Homo sapiens	51-54
2787670-0	1989	The microheterogeneity of desialylated alpha 1-antichymotrypsin: the occurrence of two amino-terminal isoforms, one lacking a His-Pro dipeptide.	Proline	130-133	serpin family A member 3	Homo sapiens	39-63
2567735-1	1989	gamma-Glutamate kinase, the enzyme that catalyzes the first step in the pathway from glutamate to proline, has been postulated to convert glutamate to a gamma-activated form (possibly gamma-glutamyl phosphate), which is reduced by a NADPH-linked reductase to yield glutamate gamma-semialdehyde (in equilibrium with delta 1-pyrroline-5-carboxylate).	Proline	98-105	2,4-dienoyl-CoA reductase 1	Homo sapiens	233-238
2750946-1	1989	The amino terminal angiotensin heptapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro [ANG-(1-7)], is the major product formed during incubation of 125I-labeled ANG I or 125I-labeled ANG II with homogenates obtained from canine dorsomedial medulla oblongata.	Proline	69-72	ANG	Canis lupus familiaris	74-77
2750946-1	1989	The amino terminal angiotensin heptapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro [ANG-(1-7)], is the major product formed during incubation of 125I-labeled ANG I or 125I-labeled ANG II with homogenates obtained from canine dorsomedial medulla oblongata.	Proline	69-72	ANG	Canis lupus familiaris	148-151
2750946-1	1989	The amino terminal angiotensin heptapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro [ANG-(1-7)], is the major product formed during incubation of 125I-labeled ANG I or 125I-labeled ANG II with homogenates obtained from canine dorsomedial medulla oblongata.	Proline	69-72	ANG	Canis lupus familiaris	148-151
2770452-2	1989	The deduced primary sequence of rat brain 5B4/NCAM-ld predicts a large cytoplasmic domain (390 amino acids, Mr 39,284) of striking amino acid composition (52% proline, alanine, serine and threonine) and little predicted alpha or beta secondary structure: its function is unknown.	Proline	159-166	neural cell adhesion molecule 1	Rattus norvegicus	46-50
2545227-7	1989	The binding of [3H]Me-TRH to caudal lobe membranes was displaced by Me-TRH, TRH, pGlu-His-Pro-Gly-NH2 and [Glu1]-TRH, with half-maximal effective doses of 33 nM, 70.7 nM, 1.23 microM and 22 microM respectively, but not by [Phe2]-TRH, TRH free acid or His-Pro-diketopiperazine.	Proline	90-93	thyrotropin releasing hormone	Gallus gallus	22-25
2545724-4	1989	Mutant proteins containing Leu, Arg, Met, or Pro at residue 175 of mature CCP were sensitive to proteolysis and were imported into isolated mitochondria as judged by proteolytic processing of the precursor.	Proline	45-48	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	74-77
2501795-1	1989	Amino acid sequencing of a CNBr digest of the tau protein isolated from bovine brain revealed an amino acid sequence of 17 residues, Pro-Gly-Leu-Lys-Glu-Ser-Pro-Leu-Gln-Ile-Gly-Ala-Ala-Pro-Gly-Leu-Lys, which we call peptide I, with heterogeneity at position 11 of glycine (peptide Ia) and proline (peptide Ib); peptide I showed no homology with the previously reported cDNA-derived mouse and human tau sequences.	Proline	289-296	microtubule associated protein tau	Homo sapiens	46-49
2813554-9	1989	Both L-arginine and L-proline, the two amino acids component of kentsin, decreased the specific activity of rat liver mitochondrial aldehyde dehydrogenase in vitro at 10(-3) mol concentration.	Proline	20-29	aldehyde dehydrogenase 2 family member	Rattus norvegicus	118-154
2763870-7	1989	Protein synthesis was assessed by measuring incorporation of [3H]proline into collagenase-digestible protein (CDP) and noncollagen protein (NCP).	Proline	65-72	cut-like homeobox 1	Rattus norvegicus	78-108
2742596-0	1989	Parathyroid hormone alteration of free and tRNA-bound proline specific activities in cultured mouse osteoblast-like cells.	Proline	54-61	parathyroid hormone	Mus musculus	0-19
2722864-1	1989	Antithrombin pescara, ARG393 to pro, caused by a CGT to CCT mutation.	Proline	32-35	serpin family C member 1	Homo sapiens	0-12
2722864-1	1989	Antithrombin pescara, ARG393 to pro, caused by a CGT to CCT mutation.	Proline	32-35	UDP glycosyltransferase 8	Homo sapiens	49-52
2722864-1	1989	Antithrombin pescara, ARG393 to pro, caused by a CGT to CCT mutation.	Proline	32-35	CCT	Homo sapiens	56-59
2764886-7	1989	The data also demonstrated that human type III procollagen has the same third base preference in codons for glycine, proline and alanine that was previously found with human and chick type I procollagen.	Proline	117-124	collagen type I alpha 2 chain	Homo sapiens	184-202
2543570-5	1989	Ribosomal protein S10 has several possible internal duplications; one is a tandem repeat of ten residues that is basic and contains two or three prolines.	Proline	145-153	ribosomal protein S10	Rattus norvegicus	0-21
2737143-3	1989	In cultured calvariae, 0.5-5 nM PTH-rp stimulated [3H]thymidine incorporation into DNA by 25-70% after 24 h of treatment and decreased relative [3H]proline incorporation into collagen by 50%; the inhibitory effect on collagen production was not altered by hydroxyurea, which decreased DNA synthesis by 85%.	Proline	148-155	parathyroid hormone-like hormone	Rattus norvegicus	32-38
2737143-4	1989	PTH-rp also increased [3H]hydroxyproline levels by 100% in culture medium from bones prelabeled with [3H]proline, indicating accelerated matrix turnover.	Proline	33-40	parathyroid hormone-like hormone	Rattus norvegicus	0-6
2471521-1	1989	(-)mRNA complementary to human angiotensin II (+)mRNA encodes the "antipeptide" Glu-Gly-Val-Tyr-Val-His-Pro-Val which is structurally related to angiotensin II.	Proline	104-107	angiotensinogen	Homo sapiens	31-45
2498128-3	1989	Based on a hydrodynamical theory, evidence is presented for the assumption that vinculin as a monomer consists of a compact spherical head 6 nm in diameter connected by a proline-rich domain to a rod-shaped tail about 20 nm in length.	Proline	171-178	vinculin	Gallus gallus	80-88
2471521-1	1989	(-)mRNA complementary to human angiotensin II (+)mRNA encodes the "antipeptide" Glu-Gly-Val-Tyr-Val-His-Pro-Val which is structurally related to angiotensin II.	Proline	104-107	angiotensinogen	Homo sapiens	145-159
2565820-1	1989	Dipeptidyl peptidase IV (DPPIV) is a serine peptidase that cleaves N-terminal dipeptides from polypeptides when the second residue is a proline or an alanine.	Proline	136-143	dipeptidylpeptidase 4	Rattus norvegicus	0-23
2565820-1	1989	Dipeptidyl peptidase IV (DPPIV) is a serine peptidase that cleaves N-terminal dipeptides from polypeptides when the second residue is a proline or an alanine.	Proline	136-143	dipeptidylpeptidase 4	Rattus norvegicus	25-30
2540218-2	1989	Using [3H]proline-labeled cells we found that IFN-gamma resulted in dose-dependent inhibition of fibroblast collagen synthesis.	Proline	10-17	interferon gamma	Homo sapiens	46-55
2565345-8	1989	This single base change results in a leucine/proline polymorphism at amino acid 33 from the NH2-terminus, and is likely to impart significant differences in the secondary structures of these two allelic forms of the GPIIIa molecule.	Proline	45-52	integrin subunit beta 3	Homo sapiens	216-222
2523891-9	1989	A model for cell surface plasminogen activation is proposed in which plasminogen binding to cells from serum medium is followed by plasminogen activation by trace amounts of bound active u-PA, to form bound plasmin, which in turn serves to produce more active u-PA from bound pro-u-PA.	Proline	51-54	plasminogen activator, urokinase	Homo sapiens	187-191
2523891-9	1989	A model for cell surface plasminogen activation is proposed in which plasminogen binding to cells from serum medium is followed by plasminogen activation by trace amounts of bound active u-PA, to form bound plasmin, which in turn serves to produce more active u-PA from bound pro-u-PA.	Proline	51-54	plasminogen	Homo sapiens	25-32
2523891-9	1989	A model for cell surface plasminogen activation is proposed in which plasminogen binding to cells from serum medium is followed by plasminogen activation by trace amounts of bound active u-PA, to form bound plasmin, which in turn serves to produce more active u-PA from bound pro-u-PA.	Proline	51-54	plasminogen activator, urokinase	Homo sapiens	260-264
2469419-5	1989	SP-B is remarkable for its high cysteine and proline content and for the hydrophobic nature of the organic solvent-soluble, mature protein.	Proline	45-52	pulmonary surfactant-associated protein B	Oryctolagus cuniculus	0-4
2523891-9	1989	A model for cell surface plasminogen activation is proposed in which plasminogen binding to cells from serum medium is followed by plasminogen activation by trace amounts of bound active u-PA, to form bound plasmin, which in turn serves to produce more active u-PA from bound pro-u-PA.	Proline	51-54	plasminogen activator, urokinase	Homo sapiens	260-264
2715178-1	1989	The tails of double-headed myosin molecules consist of an alpha-helical/coiled-coil structure composed of two identical polypeptides with a heptad repeat of hydrophobic amino acids that starts immediately after a conserved proline near position 847.	Proline	223-230	myosin heavy chain 14	Homo sapiens	27-33
2673209-5	1989	Products of most loci have multiple, overlapping substrate affinities (except for the products of Pep-D, which react only with a peptide containing a carboxyterminal proline).	Proline	166-173	peptidase D	Homo sapiens	98-103
2469950-7	1989	A synthetic arginine-rich decapeptide, with a sequence of Arg-Arg-Arg-Gly-Arg-Ser-Pro-Arg-Arg-Arg, representing amino acids 150-159 of P19 and conserved in the majority of reported hepatitis B virus, absorbed the activity to bind with P19 in seven (44%) out of 16 sera containing anti-HBic.	Proline	82-85	interleukin 23 subunit alpha	Homo sapiens	135-138
2526016-2	1989	The predicted primary structure of the 240 amino acid protein has a proline rich carboxyl terminus and shares a region of sequence similarity with other snRNP polypeptides, A and B/B".	Proline	68-75	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	153-158
2500352-0	1989	Radioimmunoassay for thyrotropin-releasing hormone precursor peptide, Lys-Arg-Gln-His-Pro-Gly-Arg-Arg.	Proline	86-89	thyrotropin releasing hormone	Rattus norvegicus	21-50
2500352-1	1989	A radioimmunoassay for thyrotropin-releasing hormone (TRH) precursor peptide Lys-Arg-Gln-His-Pro-Gly-Arg-Arg (pro-TRH), has been developed.	Proline	93-96	thyrotropin releasing hormone	Rattus norvegicus	23-52
2500352-1	1989	A radioimmunoassay for thyrotropin-releasing hormone (TRH) precursor peptide Lys-Arg-Gln-His-Pro-Gly-Arg-Arg (pro-TRH), has been developed.	Proline	93-96	thyrotropin releasing hormone	Rattus norvegicus	110-117
2500352-2	1989	Anti-pro-TRH antibody was raised in rabbits immunized with a conjugate of synthetic pro-TRH analog, Cys-Lys-Arg-Gln-His-Pro-Gly-Arg-Arg-Cys (pCC10) to bovine serum albumin.	Proline	120-123	thyrotropin releasing hormone	Rattus norvegicus	5-12
2500352-2	1989	Anti-pro-TRH antibody was raised in rabbits immunized with a conjugate of synthetic pro-TRH analog, Cys-Lys-Arg-Gln-His-Pro-Gly-Arg-Arg-Cys (pCC10) to bovine serum albumin.	Proline	120-123	thyrotropin releasing hormone	Rattus norvegicus	84-91
2785237-11	1989	In contrast, TGF beta 1 (0.01-1 ng/ml) specifically enhanced collagen formation by 60-80%, as also evidenced by significant increases in the ratio of [3H]hydroxyproline to [3H]proline incorporated in newly formed proteins.	Proline	161-168	transforming growth factor, beta 1	Rattus norvegicus	13-23
2928325-0	1989	Proline isomerism leads to multiple folded conformations of calbindin D9k: direct evidence from two-dimensional 1H NMR spectroscopy.	Proline	0-7	S100 calcium binding protein G	Homo sapiens	60-73
2488545-4	1989	Purified MSF has an estimated molecular mass of 70 kDa; amino acid analysis reveals a relatively high level of proline (13.34 residues per 100).	Proline	111-118	fibronectin 1	Homo sapiens	9-12
2928342-15	1989	Sequence information revealed that the carboxyl-terminal region of the NF-H peptide contained a unique serine-, proline-, alanine-, glutamic acid-, and lysine-rich repeat.	Proline	112-119	neurofilament heavy chain	Rattus norvegicus	71-75
2659080-0	1989	Important role of the proline residue in the signal sequence that directs the secretion of human lysozyme in Saccharomyces cerevisiae.	Proline	22-29	lysozyme	Homo sapiens	97-105
2564168-10	1989	We show here that PrP codon 102 is linked to the putative gene for the syndrome in two pedigrees, providing the best evidence to date that this familial condition is inherited despite also being infectious, and that substitution of leucine for proline at PrP codon 102 may lead to the development of Gerstmann-Straussler syndrome.	Proline	244-251	prion protein	Homo sapiens	18-21
2659080-1	1989	To elucidate the role of the proline residue in the engineered signal sequence that directs the secretion of human lysozyme in Saccharomyces cerevisiae, we have remodeled an idealized signal sequence L8 = Met-Arg-(Leu)8-Pro-Leu-Ala-Ala-Leu-Gly [Yamamoto, Y., Taniyama, Y., Kikuchi, M., & Ikehara, M. (1987) Biochem.	Proline	29-36	lysozyme	Homo sapiens	115-123
2659080-7	1989	(1) The proline residue is important for the secretion of human lysozyme and is allowed at position -4, -5, or -6.	Proline	8-15	lysozyme	Homo sapiens	64-72
2663651-1	1989	Mutations in the suf9, suf10, and suf11 genes of yeast suppress + 1 nucleotide (nt) insertions in proline codons.	Proline	98-105	SUF10	Saccharomyces cerevisiae S288C	23-28
2539165-8	1989	Our studies indicate that the final products of bradykinin degradation were the tripeptide Arg-Pro-Pro, one mole each of Ser, Pro, Gly, and Arg, and two moles of phenylalanine.	Proline	95-98	kininogen 1	Homo sapiens	48-58
2539165-3	1989	Angiotensin-converting enzyme was an effective kininase in mixtures with carboxypeptidase N at physiologic concentration and digested bradykinin to the dipeptides Phe- Arg and Ser-Pro plus the pentapeptide Arg-Pro-Pro-Gly-Phe.	Proline	180-183	angiotensin I converting enzyme	Homo sapiens	0-29
2663651-1	1989	Mutations in the suf9, suf10, and suf11 genes of yeast suppress + 1 nucleotide (nt) insertions in proline codons.	Proline	98-105	SUF11	Saccharomyces cerevisiae S288C	34-39
2663651-2	1989	Nucleotide sequence analysis indicates that the suf9 and suf11 genes are members of the proline tRNA(UGG) gene family, which also includes three other previously identified genes, suf7, suf8, and trn1.	Proline	88-95	SUF11	Saccharomyces cerevisiae S288C	57-62
2663651-2	1989	Nucleotide sequence analysis indicates that the suf9 and suf11 genes are members of the proline tRNA(UGG) gene family, which also includes three other previously identified genes, suf7, suf8, and trn1.	Proline	88-95	TRN1	Saccharomyces cerevisiae S288C	196-200
2663651-5	1989	The suf10 gene is identical in sequence to suf2, which was shown previously to encode proline tRNA(IGG).	Proline	86-93	SUF10	Saccharomyces cerevisiae S288C	4-9
2648060-9	1989	Two types of internal repeats are identified in apoB-100: amphipathic alpha-helical repeats and proline-containing repeats with high beta-sheet content.	Proline	96-103	apolipoprotein B	Homo sapiens	48-56
2720200-5	1989	[3H]Proline incorporation into collagenase digestible protein (CDP) in media was stimulated dose-dependently by IGF-I up to 2.2-fold over the control levels at 130 X 10(-9) M. Addition of 1,25(OH)2D3 (5 X 10(-11) M) and IGF-I further elevated the proline incorporation into CDP.	Proline	4-11	cut-like homeobox 1	Mus musculus	31-61
2720200-5	1989	[3H]Proline incorporation into collagenase digestible protein (CDP) in media was stimulated dose-dependently by IGF-I up to 2.2-fold over the control levels at 130 X 10(-9) M. Addition of 1,25(OH)2D3 (5 X 10(-11) M) and IGF-I further elevated the proline incorporation into CDP.	Proline	4-11	cut-like homeobox 1	Mus musculus	63-66
2720200-5	1989	[3H]Proline incorporation into collagenase digestible protein (CDP) in media was stimulated dose-dependently by IGF-I up to 2.2-fold over the control levels at 130 X 10(-9) M. Addition of 1,25(OH)2D3 (5 X 10(-11) M) and IGF-I further elevated the proline incorporation into CDP.	Proline	4-11	insulin-like growth factor 1	Mus musculus	112-117
2720200-5	1989	[3H]Proline incorporation into collagenase digestible protein (CDP) in media was stimulated dose-dependently by IGF-I up to 2.2-fold over the control levels at 130 X 10(-9) M. Addition of 1,25(OH)2D3 (5 X 10(-11) M) and IGF-I further elevated the proline incorporation into CDP.	Proline	4-11	insulin-like growth factor 1	Mus musculus	220-225
2720200-5	1989	[3H]Proline incorporation into collagenase digestible protein (CDP) in media was stimulated dose-dependently by IGF-I up to 2.2-fold over the control levels at 130 X 10(-9) M. Addition of 1,25(OH)2D3 (5 X 10(-11) M) and IGF-I further elevated the proline incorporation into CDP.	Proline	4-11	cut-like homeobox 1	Mus musculus	274-277
2720200-5	1989	[3H]Proline incorporation into collagenase digestible protein (CDP) in media was stimulated dose-dependently by IGF-I up to 2.2-fold over the control levels at 130 X 10(-9) M. Addition of 1,25(OH)2D3 (5 X 10(-11) M) and IGF-I further elevated the proline incorporation into CDP.	Proline	247-254	cut-like homeobox 1	Mus musculus	31-61
2720200-5	1989	[3H]Proline incorporation into collagenase digestible protein (CDP) in media was stimulated dose-dependently by IGF-I up to 2.2-fold over the control levels at 130 X 10(-9) M. Addition of 1,25(OH)2D3 (5 X 10(-11) M) and IGF-I further elevated the proline incorporation into CDP.	Proline	247-254	cut-like homeobox 1	Mus musculus	63-66
2720200-5	1989	[3H]Proline incorporation into collagenase digestible protein (CDP) in media was stimulated dose-dependently by IGF-I up to 2.2-fold over the control levels at 130 X 10(-9) M. Addition of 1,25(OH)2D3 (5 X 10(-11) M) and IGF-I further elevated the proline incorporation into CDP.	Proline	247-254	insulin-like growth factor 1	Mus musculus	112-117
2918226-15	1989	Comparison of the amino acid composition of the barred sand bass cofactor and of human C4bp shows similar high content of cysteine and proline but not of tryptophan.	Proline	135-142	complement component 4 binding protein alpha	Homo sapiens	87-91
2918226-16	1989	It differs from human factor H in cysteine, serine, proline, and tryptophan.	Proline	52-59	complement factor H	Homo sapiens	22-30
2747653-5	1989	Overall there is 37% sequence identity between rat and frog albumin, with exact conservation of all but one Cys residue and the Pro residues responsible for the three domain structure of the mature protein.	Proline	128-131	albumin	Rattus norvegicus	60-67
2492519-2	1989	Both hsp 90s begin with proline; the initial methionine residue is removed.	Proline	24-31	heat shock protein 90 alpha family class A member 1	Homo sapiens	5-11
2930513-3	1989	These changes have been attributed to increased hydroxylation of proline in elastin.	Proline	65-72	elastin	Oryctolagus cuniculus	76-83
2644542-1	1989	Peptidyl-prolyl cis-trans isomerase (PPIase) catalyses the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and has been shown to accelerate the refolding of several proteins in vitro.	Proline	86-93	peptidylprolyl isomerase like 1	Bos taurus	0-35
2494060-5	1989	These results indicate that the activation of boar acrosin zymogen is achieved by the removal of a C-terminal segment rich in proline residues and by the cleavage of the Arg23-Val24 bond leading to the formation of the light and heavy chains.	Proline	126-133	acrosin	Homo sapiens	51-58
2644542-1	1989	Peptidyl-prolyl cis-trans isomerase (PPIase) catalyses the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and has been shown to accelerate the refolding of several proteins in vitro.	Proline	86-93	peptidylprolyl isomerase like 1	Bos taurus	37-43
2912984-5	1989	At 0.2 M NaCl most of the amino acids were free with the exception of arginine and proline which are confined to or predominant in the basic central region of HMG 17.	Proline	83-90	high mobility group nucleosomal binding domain 2	Homo sapiens	159-165
2643580-1	1989	Resequencing estA3, an allele of the methanol-soluble heat-stable enterotoxin of Escherichia coli showed that the proline triplet 19 is in fact an alanine codon; thus, estA alleles 3 and 4 were shown to be identical.	Proline	114-121	heat stable enterotoxin A3	Escherichia coli	13-18
2707972-3	1989	Libration of the Pro-Ala and Pro-Phe peptide bond planes is suggested as the source of the small exchange contributions to 1/T1p.	Proline	17-20	CD5 molecule	Homo sapiens	125-128
2463376-6	1989	Insertion of two extra cytosines 23 bp before and 19 bp after the c-src stop codon resulted in an extension of the coding portion up to 587 amino acids, divergence of sequences after Pro-525 and replacement of Tyr-527 by a valine residue.	Proline	183-186	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	66-71
2493964-2	1989	In the present study, microinjection of 10 ng to 5 micrograms of TRH into the anterior hypothalamus (AHy) dose-dependently suppressed heat production in interscapular brown adipose tissue (BAT) in chloral hydrate-anaesthetized rats tested at a room temperature of 23 +/- 2 degrees C. This effect of TRH was mimicked by the structurally related peptides acid-TRH and luteinizing hormone releasing hormone (LH-RH), and by the TRH analog CG 3509, but not by the TRH fragments pGlu-His and His-Pro.	Proline	490-493	thyrotropin releasing hormone	Rattus norvegicus	65-68
2541599-0	1989	Parathyroid hormone regulation of proline uptake by cultured neonatal mouse osteoblastlike cells.	Proline	34-41	parathyroid hormone	Mus musculus	0-19
2541599-1	1989	Regulation of proline uptake by the synthetic amino-terminal fragment of bovine parathyroid hormone [bPTH-(1-34)] has been studied in confluent primary cultures of osteoblastlike cells isolated from neonatal mouse calvaria.	Proline	14-21	parathyroid hormone	Bos taurus	80-99
2541599-8	1989	Parathyroid hormone significantly reduced this decline, increasing the half-life of proline transport activity about fourfold.	Proline	84-91	parathyroid hormone	Mus musculus	0-19
2911013-3	1989	A carboxypeptidase activity that digested angiotensin I to des-Leu-angiotensin I, Ile-His-Pro-Phe to Ile-His-Pro and Phe, and hippuryl-L-phenylalanine to hippuric acid and Phe was detected in the granules of these NK cells.	Proline	109-112	angiotensinogen	Homo sapiens	42-55
2640567-8	1989	Sequence analysis of peak A showed that the proline at the third amino acid residue of bradykinin was replaced by hydroxyproline.	Proline	44-51	kininogen 1	Homo sapiens	87-97
2642907-6	1989	In rat liver, aspartyl-tRNA synthetase occurs in two distinct forms: a dimeric enzyme and a component of a multienzyme complex comprising the nine aminoacyl-tRNA synthetases specific for arginine, aspartic acid, glutamic acid, glutamine, isoleucine, leucine, lysine, methionine, and proline.	Proline	283-290	aspartyl-tRNA synthetase 1	Rattus norvegicus	14-38
2642904-3	1989	These results strongly support the view that the three long (alanine + proline)-rich regions of the dihydrolipoyl acetyltransferase chains are exposed to solvent and enjoy substantial conformational flexibility in the enzyme complex.	Proline	71-78	acetyltransferase	Escherichia coli	114-131
2521568-5	1989	The elevation in SOD-1 activity observed in the familial Alzheimer"s patients supports the theory that paired helical filaments are synthesized in Alzheimer"s disease by free radical hydroxylation of proline residues in paired helical filament precursor protein(s).	Proline	200-207	superoxide dismutase 1	Homo sapiens	17-22
2699394-6	1989	Studies with deletion mutants support the proposal that the antigenicity in pre-E2b is associated with the flexible proline-rich hinge region.	Proline	116-123	dihydrolipoamide branched chain transacylase E2	Homo sapiens	80-83
2566520-9	1989	Insulin decreased always BCAA but also threonine, proline, tyrosine, methionine and total aminoacid levels.	Proline	50-57	insulin	Homo sapiens	0-7
2497688-4	1989	To identify the TRH precursor in the rat hypothalamus, an antiserum was raised against the synthetic decapeptide sequence, Cys-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-Cys.	Proline	143-146	thyrotropin releasing hormone	Rattus norvegicus	16-19
2910920-3	1989	Although continuous treatment with PTH for 24-72 h inhibited [3H]proline incorporation into collagen, transient (24 h) treatment enhanced [3H]proline incorporation into collagen 24-48 h after the hormone was removed.	Proline	65-72	parathyroid hormone	Rattus norvegicus	35-38
2535874-1	1989	alpha-Melanocyte stimulating hormone (alpha-MSH) is a linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) that has diverse physiological functions in addition to its reversible darkening of amphibian skins by stimulating melanosome dispersion within melanophores.	Proline	124-127	alpha-msh	Anolis carolinensis	0-36
2535874-1	1989	alpha-Melanocyte stimulating hormone (alpha-MSH) is a linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) that has diverse physiological functions in addition to its reversible darkening of amphibian skins by stimulating melanosome dispersion within melanophores.	Proline	124-127	alpha-msh	Anolis carolinensis	38-47
2727382-7	1989	Since triplets of the Gly-Pro-X-type released by the TPP 4 are ideal substrates for DPP II, the integrated action of tripeptidyl and dipeptidyl peptidases could make a novel contribution to the renal depolymerization and reabsorption of polypeptides, in particular the proline-rich, collagen-derived sequences that possess repeating-triplet primary structures.	Proline	269-276	dipeptidylpeptidase 7	Rattus norvegicus	84-90
3180078-3	1988	The isolated mucin had a high content of threonine, serine, and proline, with 28% of the total amino acids O-glycosylated.	Proline	64-71	LOC100508689	Homo sapiens	13-18
3063603-4	1988	However, an interesting feature of the AP-2 protein is a clustered arrangement of proline and glutamine residues that have been found recently within the activation domains of other transcription factors.	Proline	82-89	transcription factor AP-2 alpha	Homo sapiens	39-43
3141416-2	1988	Rat thyrotropin-releasing hormone prohormone (pro-TRH) contains five separate copies of the TRH progenitor sequence: Gln-His-Pro-Gly.	Proline	125-128	thyrotropin releasing hormone	Rattus norvegicus	46-53
3141416-2	1988	Rat thyrotropin-releasing hormone prohormone (pro-TRH) contains five separate copies of the TRH progenitor sequence: Gln-His-Pro-Gly.	Proline	125-128	thyrotropin releasing hormone	Rattus norvegicus	50-53
3208110-6	1988	The predicted drebrin molecules are highly hydrophilic and have proline-rich sequences and long stretches of glutamate in the carboxyl-terminal region.	Proline	64-71	drebrin 1	Gallus gallus	14-21
3069842-6	1988	Among devalyl propioxatin A derivatives, the proline-containing compounds inhibited enkephalinase B and others inhibited both enzymes.	Proline	45-52	dipeptidyl peptidase 3	Homo sapiens	84-99
3069842-8	1988	Substitution of the proline by alanine also resulted in a 1,000-fold loss of inhibitory activity for enkephalinase B.	Proline	20-27	dipeptidyl peptidase 3	Homo sapiens	101-116
2475147-3	1989	We identified the NF-H multi-phosphorylation repeat domain, i.e. repeats of Lys-Ser-Pro-X (where X is a small uncharged amino acid and Ser acts as a phosphate acceptor), as the determinant recognized by 15/16 MAbs that detected NFTs in sections of AD hippocampus, and 11 of the same 16 MAbs recognised NF-M multi-phosphorylation repeats.	Proline	84-87	neurofilament heavy chain	Homo sapiens	18-22
2475147-3	1989	We identified the NF-H multi-phosphorylation repeat domain, i.e. repeats of Lys-Ser-Pro-X (where X is a small uncharged amino acid and Ser acts as a phosphate acceptor), as the determinant recognized by 15/16 MAbs that detected NFTs in sections of AD hippocampus, and 11 of the same 16 MAbs recognised NF-M multi-phosphorylation repeats.	Proline	84-87	neurofilament medium chain	Homo sapiens	302-306
2909370-3	1989	IGF-I and -II increased [3H]proline incorporation into type I collagen independently of their effect on cell replication.	Proline	28-35	insulin-like growth factor 1	Rattus norvegicus	0-13
2909370-6	1989	In Ob cells, IGF-I and -II also increased [3H]proline incorporation into type I collagen, but the effect was seen at 100 nM, and neither factor decreased collagen degradation.	Proline	46-53	insulin-like growth factor 1	Rattus norvegicus	13-26
2552247-4	1989	Tryptic mapping of nexly synthetized alpha-MSH generated two fragments with the following amino acid composition: (T1) Trp, Pro, Lys, Gly, Val and (T2) Tyr, Arg, Phe, His, Ser, Glu.	Proline	124-127	proopiomelanocortin	Homo sapiens	37-46
2470110-2	1989	This report demonstrates that human melanoma cells (M21) synthesize and express a glycoprotein receptor that shares antigenic epitopes with the vitronectin receptor on human fibroblasts and is capable of specifically recognizing the Gly-Arg-Gly-Asp-Ser-Pro sequence.	Proline	253-256	vitronectin	Homo sapiens	144-155
3266596-6	1988	Following a proline-rich segment of 17 amino acids are found six consecutive repeats with close homology to EGF.	Proline	12-19	epidermal growth factor	Homo sapiens	108-111
3198605-8	1988	These N-glycosylation sites are clustered into two domains separated by a hinge-like structure enriched with proline and serine in h-lamp-1 or proline and threonine in h-lamp-2.	Proline	109-116	lysosomal associated membrane protein 1	Homo sapiens	133-139
3242846-7	1988	The CPA of GNCP preparation was not blocked by the antiserum and scarcely inhibited in the presence of the synthetic cell attachment-promoting peptide Gly-Arg-Gly-Asp-Ser-Pro, a competitive inhibitor of fibronectin.	Proline	171-174	fibronectin 1	Mus musculus	203-214
2851328-0	1988	Replacement of a conserved proline eliminates the absorbance-detected slow folding phase of iso-2-cytochrome c.	Proline	27-34	cytochrome c, somatic	Homo sapiens	98-110
3182782-5	1988	Sequence analysis of fraction I showed that the proline at the third amino acid residue of bradykinin was replaced by hydroxyproline.	Proline	48-55	kininogen 1	Homo sapiens	91-101
3253448-6	1988	Spikes which periodically protrude from strands in our STM images of collagen appear to represent pyrrolidine ring structures in the amino acids proline and hydroxyproline.	Proline	145-152	sulfotransferase family 1A member 3	Homo sapiens	55-58
2905688-4	1988	Molecular cloning and sequencing of both the alleles of p53 gene revealed a base-pair change in codon 72 causing arginine----proline substitution in the allele with the additional BglII site.	Proline	125-132	tumor protein p53	Homo sapiens	56-59
3062363-0	1988	A regulatory region responsible for proline-specific induction of the yeast PUT2 gene is adjacent to its TATA box.	Proline	36-43	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	76-80
3062363-1	1988	Deletion analysis of the promoter of the PUT2 gene that functions in the proline utilization pathway of Saccharomyces cerevisiae identified a PUT2 upstream activation site (UAS).	Proline	73-80	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	41-45
3062363-1	1988	Deletion analysis of the promoter of the PUT2 gene that functions in the proline utilization pathway of Saccharomyces cerevisiae identified a PUT2 upstream activation site (UAS).	Proline	73-80	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	142-146
3062363-6	1988	In heterologous as well as homologous gene fusions, the PUT2 UAS appeared to be responsible for uninduced as well as proline-induced levels of expression.	Proline	117-124	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	56-60
3146142-5	1988	The difference between u-PA activity and antigen in inflammatory bowel disease tissue could be attributed to an increase in inactive pro-u-PA and u-PA-inhibitor complexes.	Proline	133-136	plasminogen activator, urokinase	Homo sapiens	23-27
3146142-5	1988	The difference between u-PA activity and antigen in inflammatory bowel disease tissue could be attributed to an increase in inactive pro-u-PA and u-PA-inhibitor complexes.	Proline	133-136	plasminogen activator, urokinase	Homo sapiens	137-141
3045563-4	1988	The most significant homology is based around the sequence Trp-Ser-Pro-Cys-Ser-Val-Thr-Cys-Gly (WSPCSVTCG), present in three copies in region I of thrombospondin (TSP), six copies in properdin (P) and one copy in all the circumsporozoite (CS) proteins sequenced so far.	Proline	67-70	thrombospondin 1	Homo sapiens	147-161
3146142-5	1988	The difference between u-PA activity and antigen in inflammatory bowel disease tissue could be attributed to an increase in inactive pro-u-PA and u-PA-inhibitor complexes.	Proline	133-136	plasminogen activator, urokinase	Homo sapiens	137-141
3150544-2	1988	One of these new derivatives, FVIII delta II, in which amino acids 771(pro)-1666(asp) have been deleted, no longer contains the protease cleavage site at amino acid position 1648(arg)-1649(glu) known to be involved in the initial step of FVIII processing.	Proline	71-74	coagulation factor VIII	Homo sapiens	30-35
2844821-7	1988	It is concluded that Ser-Lys-Thr-Ala-Ser-Pro-Trp-Lys-Ser-Ala-Arg-Leu-Met-Val-His-Thr-Val-Ala- Thr- Phe-Asn-Ser-Ile-Lys, a 24-residue peptide which bridges repeats 11 and 12 of brain alpha spectrin contains the high affinity calmodulin binding domain.	Proline	41-44	calmodulin 1	Homo sapiens	224-234
3048413-1	1988	The enzyme peptidylprolyl cis-trans isomerase (PPI) is known to catalyze proline isomerization in short proline-containing peptides.	Proline	73-80	peptidylprolyl isomerase like 1	Homo sapiens	11-45
3048413-1	1988	The enzyme peptidylprolyl cis-trans isomerase (PPI) is known to catalyze proline isomerization in short proline-containing peptides.	Proline	104-111	peptidylprolyl isomerase like 1	Homo sapiens	11-45
2841473-9	1988	Thus, it seems most likely that the defect of expression of the Emv-3 provirus is due to the presence of a proline is position 3 of the gag polyprotein, preventing the myristylation.	Proline	107-114	endogenous retrovirus group K member 9	Homo sapiens	136-151
3045563-4	1988	The most significant homology is based around the sequence Trp-Ser-Pro-Cys-Ser-Val-Thr-Cys-Gly (WSPCSVTCG), present in three copies in region I of thrombospondin (TSP), six copies in properdin (P) and one copy in all the circumsporozoite (CS) proteins sequenced so far.	Proline	67-70	thrombospondin 1	Homo sapiens	163-166
3045563-4	1988	The most significant homology is based around the sequence Trp-Ser-Pro-Cys-Ser-Val-Thr-Cys-Gly (WSPCSVTCG), present in three copies in region I of thrombospondin (TSP), six copies in properdin (P) and one copy in all the circumsporozoite (CS) proteins sequenced so far.	Proline	67-70	complement factor properdin	Homo sapiens	183-192
3135552-2	1988	The presence of four proline residues and four hydrophobic clusters located at similar positions in apolipoprotein A-II and uteroglobin is taken as the major source of stability in such tertiary structures.	Proline	21-28	apolipoprotein A2	Homo sapiens	100-119
2839508-2	1988	While each isozyme is encoded by the same structural gene, they differ by the amino acid sequence at the COOH-terminal end, with GPDH-3 having the sequence Asn-His-Pro-Glu-His-Met-COOH and with GPDH-1 extended by the three amino acid sequence Glu-Asn-Leu-COOH.	Proline	164-167	uncharacterized protein	Drosophila melanogaster	129-135
2839509-12	1988	The evolution of this PRP multigene family has been dominated by intra-exonic amplification of repeating nucleotide units coding for these and other proline-rich repeated peptides and by gene duplication.	Proline	149-156	proline rich protein HaeIII subfamily 1	Mus musculus	22-25
2457711-8	1988	Also, the sepsis-reduced clearances of glutamine and glutamate, alanine, and proline were increased (p less than 0.0001) during BCAA even though urea nitrogen production was reduced (p less than 0.0001).	Proline	77-84	AT-rich interaction domain 4B	Homo sapiens	128-132
3191114-7	1988	Proline-407 is located 14 amino acids C-terminal to the reactive site arginine of ATIII in a core region of the molecule that has been highly conserved during evolution of the serine protease inhibitor (serpin) gene family.	Proline	0-7	serpin family C member 1	Homo sapiens	82-87
3191114-8	1988	The location of this proline in the crystal structure of the homologous serpin alpha 1-antitrypsin suggests that the leucine substitution in ATIII-Utah may interfere with correct folding of the mutant gene product, leading to its rapid turnover and the low antithrombin levels observed in patient plasmas.	Proline	21-28	serpin family A member 1	Homo sapiens	79-98
3191114-8	1988	The location of this proline in the crystal structure of the homologous serpin alpha 1-antitrypsin suggests that the leucine substitution in ATIII-Utah may interfere with correct folding of the mutant gene product, leading to its rapid turnover and the low antithrombin levels observed in patient plasmas.	Proline	21-28	serpin family C member 1	Homo sapiens	141-146
3191114-8	1988	The location of this proline in the crystal structure of the homologous serpin alpha 1-antitrypsin suggests that the leucine substitution in ATIII-Utah may interfere with correct folding of the mutant gene product, leading to its rapid turnover and the low antithrombin levels observed in patient plasmas.	Proline	21-28	serpin family C member 1	Homo sapiens	257-269
3135552-2	1988	The presence of four proline residues and four hydrophobic clusters located at similar positions in apolipoprotein A-II and uteroglobin is taken as the major source of stability in such tertiary structures.	Proline	21-28	secretoglobin family 1A member 1	Homo sapiens	124-135
3138108-4	1988	The protein segment on the carboxy-terminal side of the human NF-H rod is uniquely long (greater than 600 amino acids) compared to other IF proteins and is highly charged (greater than 24% Glu, greater than 25% Lys), rich in proline (greater than 12%) and impoverished in cysteine, methionine and aromatic amino acids.	Proline	225-232	neurofilament heavy chain	Homo sapiens	62-66
3379061-3	1988	On the basis of results obtained from sequencing of the N termini of the purified HPRT A and B proteins, we also show that these amino acid substitutions are associated with differences in processing of the proteins; HPRT B, which is encoded as N-terminal Met-Pro, has a free N-terminal proline residue; HPRT A, which is encoded as N-terminal Met-Ala, lacks a free N-terminal alpha-amino group and is presumed to be acetylated following removal of the N-terminal methionine (i.e. AcO-Ala).	Proline	287-294	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	82-86
3379061-3	1988	On the basis of results obtained from sequencing of the N termini of the purified HPRT A and B proteins, we also show that these amino acid substitutions are associated with differences in processing of the proteins; HPRT B, which is encoded as N-terminal Met-Pro, has a free N-terminal proline residue; HPRT A, which is encoded as N-terminal Met-Ala, lacks a free N-terminal alpha-amino group and is presumed to be acetylated following removal of the N-terminal methionine (i.e. AcO-Ala).	Proline	287-294	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	217-223
3379061-3	1988	On the basis of results obtained from sequencing of the N termini of the purified HPRT A and B proteins, we also show that these amino acid substitutions are associated with differences in processing of the proteins; HPRT B, which is encoded as N-terminal Met-Pro, has a free N-terminal proline residue; HPRT A, which is encoded as N-terminal Met-Ala, lacks a free N-terminal alpha-amino group and is presumed to be acetylated following removal of the N-terminal methionine (i.e. AcO-Ala).	Proline	287-294	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	217-221
3379061-2	1988	On the basis of nucleotide sequence comparisons of their corresponding cDNAs, we show here that the HPRT A and B proteins differ at two positions; there is an alanine/proline substitution at amino acid position 2 and a valine/alanine substitution at amino acid position 29 (HPRT A/B proteins, respectively; total protein length, 218 amino acids).	Proline	167-174	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	100-104
3076391-0	1988	Cis-trans isomerization of the proline residue in insulin studied by 13C NMR spectroscopy.	Proline	31-38	insulin	Bos taurus	50-57
3076391-3	1988	Since insulin contains only a single proline residue, the site of the isomerization can be localized at the peptide bond linking Thr-27 and Pro-28.	Proline	37-44	insulin	Bos taurus	6-13
3076391-3	1988	Since insulin contains only a single proline residue, the site of the isomerization can be localized at the peptide bond linking Thr-27 and Pro-28.	Proline	140-143	insulin	Bos taurus	6-13
2841185-5	1988	CHA1 is probably the structural gene for the enzyme; it is an abundant RNA in cells grown with serine and threonine as nitrogen source, whereas it is not detected when cells are grown on ammonium or proline, i.e., the transcription of the CHA1 gene is induced by serine or threonine.	Proline	199-206	L-serine/L-threonine ammonia-lyase CHA1	Saccharomyces cerevisiae S288C	0-4
2836792-3	1988	The inferred amino acid sequence of NUC1 predicts that the nuclease is basic, rich in prolines, of average hydrophobicity, and has a molecular weight for the primary translation product of 37,209 daltons.	Proline	86-94	ribonuclease	Saccharomyces cerevisiae S288C	36-40
3382697-5	1988	The high frequency and clustering of proline and glycine residues in estrogen receptor, progesterone receptor and glucose-6-phosphate dehydrogenase suggests that the translating ribosomes may slow down during synthesis of these proteins due to limiting levels of these tRNAs in E2-deprived uteri.	Proline	37-44	estrogen receptor 1	Homo sapiens	69-86
3382697-5	1988	The high frequency and clustering of proline and glycine residues in estrogen receptor, progesterone receptor and glucose-6-phosphate dehydrogenase suggests that the translating ribosomes may slow down during synthesis of these proteins due to limiting levels of these tRNAs in E2-deprived uteri.	Proline	37-44	progesterone receptor	Homo sapiens	88-109
3382697-5	1988	The high frequency and clustering of proline and glycine residues in estrogen receptor, progesterone receptor and glucose-6-phosphate dehydrogenase suggests that the translating ribosomes may slow down during synthesis of these proteins due to limiting levels of these tRNAs in E2-deprived uteri.	Proline	37-44	glucose-6-phosphate dehydrogenase	Homo sapiens	114-147
2974999-5	1988	The substitution of the pyrrolidine residue by L-proline in this type of inhibitors decreased the activity against serine proteases, especially against thrombin.	Proline	47-56	coagulation factor II, thrombin	Homo sapiens	152-160
2843644-12	1988	For peptides of the series Tyr-Pro-X-Asp-Val, where X represents all L-amino acid except Trp and Pro, the temperature coefficient of the Asp4 amide proton resonance provides a measure of the beta-turn population.	Proline	31-34	napsin A aspartic peptidase	Homo sapiens	137-141
3366907-4	1988	Transient (24 h) treatment with bFGF enhanced [3H]-proline incorporation into collagen 24-48 h after the factor was removed; this effect was DNA synthesis dependent and blocked by hydroxyurea.	Proline	51-58	fibroblast growth factor 2	Rattus norvegicus	32-36
3366907-6	1988	In contrast, continuous treatment with bFGF for 24-96 h inhibited [3H]proline incorporation into type I collagen.	Proline	70-77	fibroblast growth factor 2	Rattus norvegicus	39-43
3131325-3	1988	Analysis of amino acid composition revealed that CT14 was rich in lysine and proline residues, suggesting unique structure of microtubule-binding domain of tau proteins.	Proline	77-84	sarcoma antigen 1	Homo sapiens	49-53
3380805-3	1988	One clone encodes VAMP-1 (vesicle-associated membrane protein 1), a nervous-system-specific protein of 120 amino acids whose primary sequence can be divided into three domains: a proline-rich amino terminus, a highly charged internal region, and a hydrophobic carboxyl-terminal domain that is predicted to comprise a membrane anchor.	Proline	179-186	vesicle associated membrane protein 1	Homo sapiens	18-24
3380805-3	1988	One clone encodes VAMP-1 (vesicle-associated membrane protein 1), a nervous-system-specific protein of 120 amino acids whose primary sequence can be divided into three domains: a proline-rich amino terminus, a highly charged internal region, and a hydrophobic carboxyl-terminal domain that is predicted to comprise a membrane anchor.	Proline	179-186	vesicle associated membrane protein 1	Homo sapiens	26-63
2896517-3	1988	In the case of alanine substrates (Ala in P1, dipeptidyl peptidase IV hydrolyzes such compounds where the configuration of the P2 residue is R. The penultimate residue with dipeptidyl peptidase IV can be, beside proline and alanine, dehydroproline, hydroxyproline and pipecolic acid.	Proline	212-219	dipeptidyl peptidase 4	Sus scrofa	46-69
2896517-3	1988	In the case of alanine substrates (Ala in P1, dipeptidyl peptidase IV hydrolyzes such compounds where the configuration of the P2 residue is R. The penultimate residue with dipeptidyl peptidase IV can be, beside proline and alanine, dehydroproline, hydroxyproline and pipecolic acid.	Proline	212-219	dipeptidyl peptidase 4	Sus scrofa	173-196
3366244-1	1988	Hydroxyproline (Hyp) analogues of bradykinin and lysyl-bradykinin, in which the third residue of bradykinin, proline, is replaced by hydroxyproline, were isolated from human urine.	Proline	7-14	kininogen 1	Homo sapiens	34-44
3366244-1	1988	Hydroxyproline (Hyp) analogues of bradykinin and lysyl-bradykinin, in which the third residue of bradykinin, proline, is replaced by hydroxyproline, were isolated from human urine.	Proline	7-14	kininogen 1	Homo sapiens	55-65
3366244-1	1988	Hydroxyproline (Hyp) analogues of bradykinin and lysyl-bradykinin, in which the third residue of bradykinin, proline, is replaced by hydroxyproline, were isolated from human urine.	Proline	7-14	kininogen 1	Homo sapiens	55-65
3234361-6	1988	These results indicate that proline hydroxylation in the collagen-like portion of SP-A decreases its electrophoretic mobility.	Proline	28-35	surfactant protein A2	Homo sapiens	82-86
3073376-0	1988	[Proline-rich-polypeptide from ovine colostrum (PRP): its structure and properties.	Proline	1-8	prion protein	Homo sapiens	48-51
2840952-2	1988	Molecular cloning and DNA sequence analyses revealed that the MspI polymorphism was created by a T to C transition in exon 9 of the human PAH gene, which also resulted in the conversion of a leucine codon to a proline codon.	Proline	210-217	phenylalanine hydroxylase	Homo sapiens	138-141
2832443-8	1988	These studies show that prolyl peptides are efficiently and sequentially hydrolyzed from the COOH terminus by the combined action of ACE and carboxypeptidase P, and that these enzymes may play an important role in the digestion and assimilation of proline-containing peptides.	Proline	248-255	angiotensin I converting enzyme	Rattus norvegicus	133-136
3353366-5	1988	In animal systems, it has been proposed that proline biosynthesis by pyrroline-5-carboxylate reductase (P5CR) is used to generate the NADP+ required for the synthesis of the purine precursor ribose 5-phosphate.	Proline	45-52	pyrroline-5-carboxylate reductase	Glycine max	69-102
2836700-0	1988	The Escherichia coli proB gene corrects the proline auxotrophy of Saccharomyces cerevisiae pro1 mutants.	Proline	44-51	glutamate 5-kinase	Saccharomyces cerevisiae S288C	91-95
2836700-3	1988	Yeast pro1 mutants harboring these plasmids are proline prototrophs.	Proline	48-55	glutamate 5-kinase	Saccharomyces cerevisiae S288C	6-10
3353366-5	1988	In animal systems, it has been proposed that proline biosynthesis by pyrroline-5-carboxylate reductase (P5CR) is used to generate the NADP+ required for the synthesis of the purine precursor ribose 5-phosphate.	Proline	45-52	pyrroline-5-carboxylate reductase	Glycine max	104-108
3353366-14	1988	In addition, we propose that some of the proline synthesized in the plant cytosol by P5CR is catabolized within the bacteroids by ProDH and that this represents a novel mechanism for transferring energy from the plant to its endosymbiont.	Proline	41-48	pyrroline-5-carboxylate reductase	Glycine max	85-89
3353366-14	1988	In addition, we propose that some of the proline synthesized in the plant cytosol by P5CR is catabolized within the bacteroids by ProDH and that this represents a novel mechanism for transferring energy from the plant to its endosymbiont.	Proline	41-48	proline dehydrogenase	Glycine max	130-135
3126818-4	1988	Thrombin also stimulated the mobilization of stable calcium and inorganic phosphate, the release of 3H from [3H]proline-labelled calvaria, the production of lactate and the release of the lysosomal enzymes, beta-glucuronidase and beta-N-acetylglucosaminidase.	Proline	112-119	coagulation factor II	Mus musculus	0-8
3384397-2	1988	This protein migrates Mr 45,000-70,000 dalton region with a broad singlet or doublet on SDS-PAGE, specifically binds to C3b and C4b, has an acidic pI around pH 4, is rich in proline in amino acid analysis, possesses both N-linked and O-linked oligosaccharides, generates iC3b by acting as a cofactor for I-mediated C3b cleavage, and does not disassemble the C3 convertases.	Proline	174-181	complement C3	Homo sapiens	120-123
3345578-5	1988	To determine the conditions under which ASC is most effective as a nitrosation inhibitor, we examined the kinetics of the reactions between nitrite and ASC and between nitrite and proline.	Proline	180-187	PYD and CARD domain containing	Homo sapiens	40-43
3384397-2	1988	This protein migrates Mr 45,000-70,000 dalton region with a broad singlet or doublet on SDS-PAGE, specifically binds to C3b and C4b, has an acidic pI around pH 4, is rich in proline in amino acid analysis, possesses both N-linked and O-linked oligosaccharides, generates iC3b by acting as a cofactor for I-mediated C3b cleavage, and does not disassemble the C3 convertases.	Proline	174-181	complement C4B (Chido blood group)	Homo sapiens	128-131
3384397-2	1988	This protein migrates Mr 45,000-70,000 dalton region with a broad singlet or doublet on SDS-PAGE, specifically binds to C3b and C4b, has an acidic pI around pH 4, is rich in proline in amino acid analysis, possesses both N-linked and O-linked oligosaccharides, generates iC3b by acting as a cofactor for I-mediated C3b cleavage, and does not disassemble the C3 convertases.	Proline	174-181	complement C3	Homo sapiens	272-275
3346880-1	1988	Results from previous studies indicate that rabbit liver microsomal cytochrome P-450 catalyzes the C-5" two-electron oxidation of (S)-nicotine stereoselectivity with preferential loss of the pro-(E)-hydrogen atom trans to the pyridine ring.	Proline	191-194	cytochrome P-450	Oryctolagus cuniculus	68-84
3279210-2	1988	N-Terminal Boc-protected inhibitors containing Pro psi[CH2O]Phe in positions P4-P3 were potent inhibitors of renin, with Boc-Phe-Pro psi[CH2O]Phe-His-Leu psi[CH(OH)CH2]Val-Ile-(2-aminomethyl) pyridine (17) having an IC50 of 1.6 X 10(-9) M.	Proline	47-50	renin	Homo sapiens	109-114
3346880-1	1988	Results from previous studies indicate that rabbit liver microsomal cytochrome P-450 catalyzes the C-5" two-electron oxidation of (S)-nicotine stereoselectivity with preferential loss of the pro-(E)-hydrogen atom trans to the pyridine ring.	Proline	191-194	complement C5	Oryctolagus cuniculus	99-102
3257775-3	1988	The predicted amino acid sequence of the putative mouse CD2 protein is consistent with that of a transmembrane glycoprotein, i.e., it consists of an N-terminal region of 186 amino acids bearing six potential N-glycosylation sites, a hydrophobic transmembrane segment of 25 residues, and a large cytoplasmic region of 116 amino acids rich in proline and basic residues.	Proline	341-348	CD2 antigen	Mus musculus	56-59
2450354-1	1988	The sequence Lys-Ser-Pro-Val-Pro-Lys-Ser-Pro-Val-Glu-Glu-Lys-Gly repeats six times serially in the human midsized neurofilament (NF) protein (NF-M).	Proline	21-24	neurofilament medium chain	Homo sapiens	142-146
3280807-2	1988	Mutations at the suf12 locus were isolated in Saccharomyces cerevisiae as extragenic suppressors of +1 frameshift mutations in glycine (GGX) and proline (CCX) codons, as well as UGA and UAG nonsense mutations.	Proline	145-152	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	17-22
2835228-3	1988	The putative protein encoded by mst(3)gl-9 is mostly composed of repetitive Cys-Gly-Pro motifs.	Proline	84-87	Male-specific RNA 87F	Drosophila melanogaster	32-42
2448300-7	1988	The sequence of the peptide, Ser-Arg-Arg-Pro-[32PO4]Ser-Arg-Ala-Thr, corresponds to residues 374-381 which are located in the heparin-binding fragment of vitronectin identified by Suzuki et al.	Proline	41-45	vitronectin	Homo sapiens	154-165
3422480-6	1988	The HRGP is thus distinct both in its amino acid content and in its pentameric repeat of Pro-Pro-Val-Tyr-Lys, with half of the prolines being hydroxylated.	Proline	127-135	cell wall protein	Glycine max	4-8
3346064-3	1988	Replacement of the proline residue in position 7 with alanine reduced the pressor and vascular contractile response to less than 1% of Ang II.	Proline	19-26	angiotensinogen	Homo sapiens	135-141
3346064-5	1988	The results of pharmacological evaluation of various position 7-substituted analogues were as follows: 1) Replacement of proline in position 7 of angiotensin I (Ang I) and Ang II with primary amino acids produced cardiac-specific, positive inotropic properties.	Proline	121-128	angiotensinogen	Homo sapiens	146-159
3346064-5	1988	The results of pharmacological evaluation of various position 7-substituted analogues were as follows: 1) Replacement of proline in position 7 of angiotensin I (Ang I) and Ang II with primary amino acids produced cardiac-specific, positive inotropic properties.	Proline	121-128	angiotensinogen	Homo sapiens	161-166
3346064-5	1988	The results of pharmacological evaluation of various position 7-substituted analogues were as follows: 1) Replacement of proline in position 7 of angiotensin I (Ang I) and Ang II with primary amino acids produced cardiac-specific, positive inotropic properties.	Proline	121-128	angiotensinogen	Homo sapiens	172-178
3262362-5	1988	IGF I and TGF beta stimulated [3H]proline incorporation into calvarial collagen while the other growth factors studied did not; 1,25(OH)2D3 inhibited collagen synthesis in control as well as in IGF I and TGF beta treated calvariae.	Proline	34-41	insulin-like growth factor 1	Rattus norvegicus	0-5
3262362-5	1988	IGF I and TGF beta stimulated [3H]proline incorporation into calvarial collagen while the other growth factors studied did not; 1,25(OH)2D3 inhibited collagen synthesis in control as well as in IGF I and TGF beta treated calvariae.	Proline	34-41	transforming growth factor, beta 1	Rattus norvegicus	10-18
3248674-7	1988	Enzymes in this category are mitochondrial MAO from different tissues; (b) The second type of deamination involves the abstraction of pro-S hydrogen.	Proline	134-139	monoamine oxidase A	Rattus norvegicus	43-46
3148067-6	1988	We suggest that in prolidase-deficient fibroblasts, this rise in prolinase activity constitutes an attempt to compensate for the prolidase deficiency by increasing the greatly reduced intracellular proline pool.	Proline	198-205	peptidase D	Homo sapiens	19-28
3687941-0	1987	Alleles at the PRH1 locus coding for the human salivary-acidic proline-rich proteins Pa, Db, and PIF.	Proline	63-70	proline rich protein HaeIII subfamily 1	Homo sapiens	15-19
3222246-3	1988	The isolated mucin had a high content of threonine, serine, and proline, with 31% of the amino acid residues O-glycosylated.	Proline	64-71	LOC100508689	Homo sapiens	13-18
3139928-1	1988	A 17-year-old girl was shown to have prolidase deficiency on the basis of the presence of large amounts of proline-containing dipeptides in urine and an almost complete absence of prolidase in plasma and erythrocytes.	Proline	107-114	peptidase D	Homo sapiens	37-46
20501238-1	1988	A peptidase inactivating neurotensin at the Pro(10)-Tyr(11) peptidyl bond, leading to the biologically inactive fragments neurotensin(1-10) and neurotensin(11-13) was purified from rat brain homogenate.	Proline	44-48	neurotensin	Rattus norvegicus	25-36
2827651-1	1987	We synthesized a hexapeptide, Gly-His-His-Pro-His-Gly, previously identified as a tandem motif in the histidine-rich glycoprotein (HRG) which has multiple heme-binding sites.	Proline	42-45	histidine rich glycoprotein	Homo sapiens	102-129
2827651-1	1987	We synthesized a hexapeptide, Gly-His-His-Pro-His-Gly, previously identified as a tandem motif in the histidine-rich glycoprotein (HRG) which has multiple heme-binding sites.	Proline	42-45	histidine rich glycoprotein	Homo sapiens	131-134
2827504-4	1987	When a variety of N-blocked synthetic peptides were used as potential substrates for ACE, activity was highest with those containing proline at the carboxy terminal position.	Proline	133-140	angiotensin I converting enzyme	Rattus norvegicus	85-88
3687941-0	1987	Alleles at the PRH1 locus coding for the human salivary-acidic proline-rich proteins Pa, Db, and PIF.	Proline	63-70	PIF1 5'-to-3' DNA helicase	Homo sapiens	97-100
3687941-2	1987	Their derived amino acid sequences and that previously determined for the PIF protein completely explain the electrophoretic phenotypes of the acidic proline-rich proteins (PRPs) Pa, Db, and PIF.	Proline	150-157	PIF1 5'-to-3' DNA helicase	Homo sapiens	74-77
2961770-1	1987	Keratinocyte attachment to fibronectin (FN) substrata was inhibited by the peptide Gly-Arg-Gly-Asp-Ser-Pro-Cys, but not by the variant peptide Gly-Arg-Gly-Glu-Ser-Pro.	Proline	103-106	fibronectin 1	Homo sapiens	27-38
2824433-1	1987	The PRO1, PRO2, and PRO3 genes were isolated by functional complementation of pro1, pro2, and pro3 (proline-requiring) strains of Saccharomyces cerevisiae.	Proline	100-107	glutamate 5-kinase	Saccharomyces cerevisiae S288C	4-8
2824433-1	1987	The PRO1, PRO2, and PRO3 genes were isolated by functional complementation of pro1, pro2, and pro3 (proline-requiring) strains of Saccharomyces cerevisiae.	Proline	100-107	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	20-24
2824433-1	1987	The PRO1, PRO2, and PRO3 genes were isolated by functional complementation of pro1, pro2, and pro3 (proline-requiring) strains of Saccharomyces cerevisiae.	Proline	100-107	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	94-98
3435452-3	1987	Secreted mucin (SM) differed from intracellular mucin (IM) by having a higher proportion of "minor" mucin amino acids (aspartic acid, glutamic acid, glycine and alanine) and a lower proportion of "major" amino acids (serine, proline and threonine).	Proline	225-232	solute carrier family 13 member 2	Rattus norvegicus	9-14
3691742-0	1987	4-Proline and 4-hydroxyproline analogs of arginine vasopressin: role of the proline substitution in the two beta-turns of vasopressin.	Proline	23-30	arginine vasopressin	Rattus norvegicus	51-62
2961770-1	1987	Keratinocyte attachment to fibronectin (FN) substrata was inhibited by the peptide Gly-Arg-Gly-Asp-Ser-Pro-Cys, but not by the variant peptide Gly-Arg-Gly-Glu-Ser-Pro.	Proline	103-106	fibronectin 1	Homo sapiens	40-42
3121434-3	1987	Normal regulation is not restored when the cells are grown on arginine as the sole nitrogen source and put3-75 cells remain sensitive to the proline analog, L-azetidine-2-carboxylic acid, indicating that the block is not at the level of transport of the inducer, proline.	Proline	141-148	Put3p	Saccharomyces cerevisiae S288C	103-107
3125423-0	1987	Proline utilization in Saccharomyces cerevisiae: sequence, regulation, and mitochondrial localization of the PUT1 gene product.	Proline	0-7	proline dehydrogenase	Saccharomyces cerevisiae S288C	109-113
3125423-5	1987	PUT1 is inducible by proline, responds only slightly to carbon catabolite repression, and is not regulated by the cytochrome activator proteins HAP1 and HAP2.	Proline	21-28	proline dehydrogenase	Saccharomyces cerevisiae S288C	0-4
3121434-1	1987	A mutation has been identified that prevents Saccharomyces cerevisiae cells from growing on proline as the sole source of nitrogen, causes noninducible expression of the PUT1 and PUT2 genes, and is completely recessive.	Proline	92-99	proline dehydrogenase	Saccharomyces cerevisiae S288C	170-174
3121434-1	1987	A mutation has been identified that prevents Saccharomyces cerevisiae cells from growing on proline as the sole source of nitrogen, causes noninducible expression of the PUT1 and PUT2 genes, and is completely recessive.	Proline	92-99	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	179-183
3427058-8	1987	Quantitative analysis of sequencer results indicated that the residues in TnI that appeared to be most highly cross-linked to Cys-98 of TnC were Arg-108 and Pro-110, and to a lesser extent Arg-103 and Lys-107.	Proline	157-160	troponin I, fast skeletal muscle	Oryctolagus cuniculus	74-77
3427058-8	1987	Quantitative analysis of sequencer results indicated that the residues in TnI that appeared to be most highly cross-linked to Cys-98 of TnC were Arg-108 and Pro-110, and to a lesser extent Arg-103 and Lys-107.	Proline	157-160	tenascin	Oryctolagus cuniculus	136-139
3665833-2	1987	TNF alpha at 100-100,000 U/ml stimulated [3H]thymidine incorporation into DNA, an effect that appeared after 24 h of treatment and lasted 96 h. Transient (24-h) treatment with TNF alpha increased [3H]proline incorporation into type I collagen 24-72 h after the factor was removed; this effect was DNA synthesis dependent and blocked by hydroxyurea.	Proline	200-207	tumor necrosis factor	Rattus norvegicus	0-9
3665833-2	1987	TNF alpha at 100-100,000 U/ml stimulated [3H]thymidine incorporation into DNA, an effect that appeared after 24 h of treatment and lasted 96 h. Transient (24-h) treatment with TNF alpha increased [3H]proline incorporation into type I collagen 24-72 h after the factor was removed; this effect was DNA synthesis dependent and blocked by hydroxyurea.	Proline	200-207	tumor necrosis factor-like	Rattus norvegicus	0-3
3665833-4	1987	In contrast, continuous treatment with TNF alpha for 48-96 h caused a marked inhibition on [3H]proline incorporation into type I collagen and alkaline phosphatase activity.	Proline	95-102	tumor necrosis factor	Rattus norvegicus	39-48
2958239-6	1987	Several other organic solutes (proline, glycine, trimethylamine N-oxide, glycerol, and myo-inositol) that afford cryoprotection to PFK, an effect enhanced by the addition of zinc, do not stabilize the enzyme during air-drying, even if zinc is present.	Proline	31-38	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	131-134
3676109-5	1987	HPL chromatography, amino acid composition as well as sequence determination of the abnormal peptide, indicated that a glutamine was replaced by a proline at position beta 131 (H9).	Proline	147-154	galectin 1	Homo sapiens	0-3
2887633-0	1987	Sodium-dependent proline uptake in the rat hippocampal formation: association with ipsilateral-commissural projections of CA3 pyramidal cells.	Proline	17-24	carbonic anhydrase 3	Rattus norvegicus	122-125
2887633-8	1987	Therefore proline may play an important role in transmission at synapses made by the CA3-derived Schaffer collateral, commissural, and ipsilateral associational fibers.	Proline	10-17	carbonic anhydrase 3	Rattus norvegicus	85-88
2887633-2	1987	Among hippocampal regions, Na+-dependent proline uptake was significantly greater in areas CA1 and CA2-CA3-CA4 than in the fascia dentata, whereas there was no marked regional difference in the distribution of Na+-dependent gamma-[14C]aminobutyric acid ([14C]GABA) uptake.	Proline	41-48	carbonic anhydrase 1	Rattus norvegicus	91-94
2887633-2	1987	Among hippocampal regions, Na+-dependent proline uptake was significantly greater in areas CA1 and CA2-CA3-CA4 than in the fascia dentata, whereas there was no marked regional difference in the distribution of Na+-dependent gamma-[14C]aminobutyric acid ([14C]GABA) uptake.	Proline	41-48	carbonic anhydrase 2	Rattus norvegicus	99-102
2887633-2	1987	Among hippocampal regions, Na+-dependent proline uptake was significantly greater in areas CA1 and CA2-CA3-CA4 than in the fascia dentata, whereas there was no marked regional difference in the distribution of Na+-dependent gamma-[14C]aminobutyric acid ([14C]GABA) uptake.	Proline	41-48	carbonic anhydrase 3	Rattus norvegicus	103-106
2887633-2	1987	Among hippocampal regions, Na+-dependent proline uptake was significantly greater in areas CA1 and CA2-CA3-CA4 than in the fascia dentata, whereas there was no marked regional difference in the distribution of Na+-dependent gamma-[14C]aminobutyric acid ([14C]GABA) uptake.	Proline	41-48	carbonic anhydrase 4	Rattus norvegicus	107-110
2887633-3	1987	A bilateral kainic acid lesion, which destroyed most of the CA3 hippocampal pyramidal cells, reduced Na+-dependent proline uptake by an average of 41% in area CA1 and 52% in area CA2-CA3-CA4, without affecting the Na+-dependent uptake of GABA.	Proline	115-122	carbonic anhydrase 3	Rattus norvegicus	60-63
2887633-3	1987	A bilateral kainic acid lesion, which destroyed most of the CA3 hippocampal pyramidal cells, reduced Na+-dependent proline uptake by an average of 41% in area CA1 and 52% in area CA2-CA3-CA4, without affecting the Na+-dependent uptake of GABA.	Proline	115-122	carbonic anhydrase 1	Rattus norvegicus	159-162
2887633-3	1987	A bilateral kainic acid lesion, which destroyed most of the CA3 hippocampal pyramidal cells, reduced Na+-dependent proline uptake by an average of 41% in area CA1 and 52% in area CA2-CA3-CA4, without affecting the Na+-dependent uptake of GABA.	Proline	115-122	carbonic anhydrase 3	Rattus norvegicus	183-186
2887633-3	1987	A bilateral kainic acid lesion, which destroyed most of the CA3 hippocampal pyramidal cells, reduced Na+-dependent proline uptake by an average of 41% in area CA1 and 52% in area CA2-CA3-CA4, without affecting the Na+-dependent uptake of GABA.	Proline	115-122	carbonic anhydrase 4	Rattus norvegicus	187-190
2887633-7	1987	Ipsilateral-commissural projections of CA3 hippocampal pyramidal cells appear to possess nearly as great a capacity for taking up proline as for taking up glutamate, a probable transmitter of these pathways.	Proline	130-137	carbonic anhydrase 3	Rattus norvegicus	39-42
2442159-5	1987	The predicted amino acid composition of P-57 is rather unusual in that it is highly enriched in alanine, glutamic acid, and lysine residues, and relatively enriched with proline residues.	Proline	170-177	coronin, actin binding protein 1A	Mus musculus	40-44
3305015-9	1987	259, 939-941], the heparin-binding site of antithrombin III has been suggested to be in the region of Pro-41, Arg-47 and Trp-49.	Proline	102-105	serpin family C member 1	Homo sapiens	43-59
2820751-4	1987	The cytoplasmic region of T11 is a lengthy, proline-rich segment; secondary structural analysis predicts it to have a nonglobular conformation.	Proline	44-51	CD2 molecule	Homo sapiens	26-29
3118225-0	1987	Is all cyclo(His-Pro) derived from thyrotropin-releasing hormone?	Proline	17-20	thyrotropin releasing hormone	Homo sapiens	35-64
2443507-2	1987	This report demonstrates that human melanoma cells (M21) synthesize and express a glycoprotein receptor that shares antigenic epitopes with the vitronectin receptor on human fibroblasts and is capable of specifically recognizing the Gly-Arg-Gly-Asp-Ser-Pro sequence.	Proline	253-256	vitronectin	Homo sapiens	144-155
3039169-2	1987	There is evidence that the amino-terminal region of gp55 forms a dualtropic-specific domain that is connected to the remainder of the glycoprotein by a proline-rich linker (C. Machida, R. Bestwick, B. Boswell, and D. Kabat, Virology 144:158-172, 1985).	Proline	152-159	neuroplastin	Homo sapiens	52-56
2820123-8	1987	In contrast to the variable regions, other sequences and the overall VP2 structure (including cysteine, proline, and glycine residues) were highly conserved.	Proline	104-111	VP2	Bluetongue virus	69-72
3118225-7	1987	Thus, both TRH and cyclo(His-Pro) share a common precursor, prepro[TRH/Cyclo(His-Pro)].	Proline	29-32	thyrotropin releasing hormone	Homo sapiens	67-70
3301405-3	1987	One possible reason for this resistance is the proline content of the peptide and the discrimination against proline residues at three or four subsites of cathepsin B.	Proline	109-116	cathepsin B	Rattus norvegicus	155-166
3652906-4	1987	Three substitutions are within the predicted rat IGF-I sequence: a Pro for Asp in the B domain, an Ile for Ser in the C domain, and Thr for Ala in the D domain.	Proline	67-70	insulin-like growth factor 1	Rattus norvegicus	49-54
2887211-1	1987	A technique of derivatizing proline and 4-hydroxyproline with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole was used to measure the radioactivities, concentrations and specific activities of proline and hydroxyproline.	Proline	28-35	OXA1L mitochondrial inner membrane protein	Homo sapiens	86-91
2887211-1	1987	A technique of derivatizing proline and 4-hydroxyproline with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole was used to measure the radioactivities, concentrations and specific activities of proline and hydroxyproline.	Proline	49-56	OXA1L mitochondrial inner membrane protein	Homo sapiens	86-91
3612693-1	1987	Three arginine-vasopressin (AVP) analogues in which the proline residue in position 7 was substituted with 4-hydroxyproline were synthesized by solid-phase techniques, and their biological activities were evaluated by antidiuretic, pressor, and uterotonic bioassays.	Proline	56-63	arginine vasopressin	Homo sapiens	6-26
2885326-2	1987	Measurement of the stereospecific release of the pro-S proton from C-4" of enzyme-bound pyridoxamine 5"-phosphate provides an experimental means to probe parts of the active site of aspartate aminotransferase independently of substrate turnover (Tobler, H. P., Christen, P., and Gehring, H. (1986) J. Biol.	Proline	49-54	complement C4A (Rodgers blood group)	Homo sapiens	67-70
3109876-1	1987	The sequence of rat hypothalamic pro-TRH, deduced by sequencing of cDNA, contains five copies of the TRH progenitor sequence Gln-His-Pro-Gly flanked by paired basic amino acid sequences.	Proline	133-136	thyrotropin releasing hormone	Rattus norvegicus	33-40
3109876-1	1987	The sequence of rat hypothalamic pro-TRH, deduced by sequencing of cDNA, contains five copies of the TRH progenitor sequence Gln-His-Pro-Gly flanked by paired basic amino acid sequences.	Proline	133-136	thyrotropin releasing hormone	Rattus norvegicus	37-40
3297160-0	1987	A mutant pyruvate dehydrogenase complex of Escherichia coli deleted in the (alanine + proline)-rich region of the acetyltransferase component.	Proline	86-93	acetyltransferase	Escherichia coli	114-131
3498189-4	1987	In addition, loss of potency due to removal of residues Pro and Val was more marked in Rana (alpha-MSH-(1-11) = 0.1%) than in Anolis (alpha-MSH-(1-11) = 1%), suggesting that this C-terminal sequence is necessary for pigmentary activity in the frog melanophore.	Proline	56-59	alpha-msh	Anolis carolinensis	93-102
3297160-1	1987	The acetyltransferase chains of the pyruvate dehydrogenase complex of Escherichia coli contain conformationally mobile (alanine + proline)-rich segments that link the lipoyl domains to each other and to the subunit-binding and catalytic domain, and facilitate the intramolecular coupling of active sites in the complex.	Proline	130-137	acetyltransferase	Escherichia coli	4-21
3297167-5	1987	Biochemical analysis of the mucin before and after exposure to filtrate revealed a rise in the combined percentage of serine, threonine and proline (53-58%), suggesting that poorly glycosylated areas (which are less abundant in these amino acids) were being partly removed from the mucin.	Proline	140-147	solute carrier family 13 member 2	Rattus norvegicus	28-33
3494748-5	1987	Sequence analysis of amino acids in degraded native alpha 1-PI showed that macrophage elastase attacked a single peptide bond between Pro-357 and Met-358, the latter representing the P1 reactive-site residue of alpha 1-PI.	Proline	134-137	matrix metallopeptidase 12	Mus musculus	75-94
3109909-2	1987	Peptides related to TRH were detected by trypsin digestion and radioimmunoassay with an antibody to TRH or an antibody raised against the pentapeptide Glp-His-Pro-Gly-Lys.	Proline	159-162	thyrotropin releasing hormone	Rattus norvegicus	20-23
3109514-2	1987	Publication of the amino acid sequence of beta-MSP revealed a greater than 96% homology with "beta-inhibin," with only a proline-threonine substitution at positions 39 and 40, and the omission of a glycine at position 93.	Proline	121-128	microseminoprotein, beta	Rattus norvegicus	42-50
3035180-1	1987	The synthesis of a series of novel, potent angiotensin converting enzyme (ACE) inhibitors containing saturated bicyclic amino acids in place of proline is described.	Proline	144-151	angiotensin I converting enzyme	Homo sapiens	43-72
3035180-1	1987	The synthesis of a series of novel, potent angiotensin converting enzyme (ACE) inhibitors containing saturated bicyclic amino acids in place of proline is described.	Proline	144-151	angiotensin I converting enzyme	Homo sapiens	74-77
3035180-2	1987	Octahydroindole-2-carboxylic acid, octahydroisoindole-1-carboxylic acid, and octahydro-3-oxoisoindole-1-carboxylic acid can replace proline in both sulfhydryl and non-sulfhydryl ACE inhibitors to give compounds equipotent to captopril and enalapril both in vitro and in vivo.	Proline	132-139	angiotensin I converting enzyme	Homo sapiens	178-181
3552672-9	1987	The only known positive factor in proline permease regulation, the nitrogen permease reactivator protein Npr1, is believed to counteract the inactivation process on derepressing media.	Proline	34-41	serine/threonine protein kinase NPR1	Saccharomyces cerevisiae S288C	105-109
3304752-3	1987	The gene for human gastrin has been isolated, and it encodes a pre-pro-gastrin which is a 101-aminoacid peptide containing within it the structure of big gastrin (G34) with a C-terminal glycine extension.	Proline	67-71	gastrin	Homo sapiens	19-26
2442578-0	1987	[A case of association of Hb C Ziguinchor (alpha A2 beta 6-2 (A3) Glu replaced by Val beta 58 (E2) Pro replaced by Arg) with a hereditary persistence of fetal hemoglobin (HPFH).	Proline	99-102	HBFQTL2	Homo sapiens	171-175
3494079-7	1987	These data indicate that although the leu-pro-pro-ser-arg sequence is able to provide both required signals for p23-induced Ig secretion in spleen cell cultures, there may be subtle differences in how the cell types involved in this response interact with and/or are activated by this sequence.	Proline	42-45	prostaglandin E synthase 3	Mus musculus	112-115
3494079-7	1987	These data indicate that although the leu-pro-pro-ser-arg sequence is able to provide both required signals for p23-induced Ig secretion in spleen cell cultures, there may be subtle differences in how the cell types involved in this response interact with and/or are activated by this sequence.	Proline	46-49	prostaglandin E synthase 3	Mus musculus	112-115
2436231-1	1987	A highly immunogenic epitope from a conserved COOH-terminal region of the human immunodeficiency virus (HIV) gp120 envelope protein has been identified with antisera from HIV-seropositive subjects and a synthetic peptide (SP-22) containing 15 amino acids from this region (Ala-Pro-Thr-Lys-Ala-Lys-Arg-Arg-Val-Val-Gln-Arg-Glu-Lys-Arg).	Proline	277-280	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	109-114
2436231-1	1987	A highly immunogenic epitope from a conserved COOH-terminal region of the human immunodeficiency virus (HIV) gp120 envelope protein has been identified with antisera from HIV-seropositive subjects and a synthetic peptide (SP-22) containing 15 amino acids from this region (Ala-Pro-Thr-Lys-Ala-Lys-Arg-Arg-Val-Val-Gln-Arg-Glu-Lys-Arg).	Proline	277-280	peroxiredoxin 3	Homo sapiens	222-227
3551956-5	1987	The human progesterone receptor is characterized, as is the rabbit receptor, by the very high proline content of its N-terminal region.	Proline	94-101	progesterone receptor	Homo sapiens	10-31
3552116-11	1987	We suggest that dipeptidyl peptidase-II may play a role in glial processing of brain peptides which possess an N-terminal penultimate proline residue.	Proline	134-141	dipeptidylpeptidase 7	Rattus norvegicus	16-39
3548429-1	1987	Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4).	Proline	42-45	gonadotropin releasing hormone 1	Rattus norvegicus	98-102
3828457-10	1987	We further conjecture that in solution the swivel located between myosin subfragments 1 and 2 (S-2 and S-1) is due to a locally random conformation of the chains caused by the presence of a proline residue at the point that physically separates the coiled coil from the globular portion of myosin.	Proline	190-197	myosin heavy chain 14	Homo sapiens	66-72
3103364-6	1987	The biological activity of TRH appears to be more effectively increased by replacing an H atom by an amyl group in the C-terminal amide function of the proline residue of TRH than by a tyramyl group in the same residue.	Proline	152-159	thyrotropin releasing hormone	Rattus norvegicus	27-30
3103364-6	1987	The biological activity of TRH appears to be more effectively increased by replacing an H atom by an amyl group in the C-terminal amide function of the proline residue of TRH than by a tyramyl group in the same residue.	Proline	152-159	thyrotropin releasing hormone	Rattus norvegicus	171-174
3828457-10	1987	We further conjecture that in solution the swivel located between myosin subfragments 1 and 2 (S-2 and S-1) is due to a locally random conformation of the chains caused by the presence of a proline residue at the point that physically separates the coiled coil from the globular portion of myosin.	Proline	190-197	ribosomal protein S2	Homo sapiens	95-98
3828457-10	1987	We further conjecture that in solution the swivel located between myosin subfragments 1 and 2 (S-2 and S-1) is due to a locally random conformation of the chains caused by the presence of a proline residue at the point that physically separates the coiled coil from the globular portion of myosin.	Proline	190-197	proteasome 26S subunit, non-ATPase 1	Homo sapiens	103-106
3828457-10	1987	We further conjecture that in solution the swivel located between myosin subfragments 1 and 2 (S-2 and S-1) is due to a locally random conformation of the chains caused by the presence of a proline residue at the point that physically separates the coiled coil from the globular portion of myosin.	Proline	190-197	myosin heavy chain 14	Homo sapiens	290-296
3295483-3	1987	A ts mutation in hlyC leads to a pro----leu exchange in amino acid position 53 of HlyC.	Proline	33-36	hemolysin transport protein	Escherichia coli	17-21
3305626-3	1987	PRG (38.9 kDa) contains 40% carbohydrate consisting of 6 triantennary N-linked units and a single peptide chain of 231 amino acids, 75% of which = PRO + GLY + GLN.	Proline	147-150	proline rich protein BstNI subfamily 3	Homo sapiens	0-3
3476566-2	1987	The major acidic proline-rich proteins and the proline-rich phosphopeptide, statherin, of man and macaques have been shown to be potent inhibitors of calcium phosphate precipitation and are thought to function in the oral environment by maintaining saliva supersaturated with respect to calcium phosphate salts.	Proline	47-54	statherin	Homo sapiens	76-85
3106615-1	1987	A number of N-benzenesulfonylglycines, alanines, sarcosine, and prolines, which contain the minimum pharmacophore moieties necessary for aldose reductase inhibitory activity, were prepared and tested in the rat lens assay.	Proline	64-72	aldo-keto reductase family 1 member B1	Rattus norvegicus	137-153
3295483-3	1987	A ts mutation in hlyC leads to a pro----leu exchange in amino acid position 53 of HlyC.	Proline	33-36	hemolysin transport protein	Escherichia coli	82-86
2485065-5	1987	The homologous fungal aspartic proteinase, endothiapepsin, has been cocrystallised with human renin inhibitors of the type His-Pro-Phe-His-Leu-R-Val-Ile-His, where R indicates a reduced carbonyl analogue of the scissile peptide bond.	Proline	127-130	renin	Homo sapiens	94-99
3583682-4	1987	A second isozyme, designated AII (or A4), has a neutral pI, is located in the mitochondrial matrix, and is thought to be involved primarily in the production of ornithine as a precursor of proline and glutamate.	Proline	189-196	NLR family pyrin domain containing 3	Homo sapiens	29-32
2948571-10	1987	Several other organic solutes (proline, 4-hydroxyproline, glycine, trimethylamine N-oxide, glycerol and myo-inositol) that afford cryoprotection to phosphofructokinase, an effect enhanced by the addition of zinc, do not stabilize the enzyme during freeze-drying, even if zinc is present.	Proline	31-38	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	148-167
2955802-3	1987	AHPrBP inhibited PTH-stimulated release of 3H from bones prelabelled with [3H]-proline.	Proline	79-86	parathyroid hormone	Mus musculus	17-20
3678106-13	1987	Primary fetal human brain cultures similarly treated with the proline analogue were found to be highly enriched for glial cells; these cultures were more than 90% GFAP positive.	Proline	62-69	glial fibrillary acidic protein	Homo sapiens	163-167
2485059-5	1987	Several newer ACE inhibitors have increased potency and/or improved pharmacokinetic properties due to modifications such as substitution of the proline ring or replacement of the methyl side chain analogous to Ala by an aminobutyl residue analogous to Lys.	Proline	144-151	angiotensin I converting enzyme	Homo sapiens	14-17
2485065-3	1987	The minimal length for an effective substrate has been characterised as an octapeptide sequence derived from the amino terminal portion of angiotensinogen (residues 6----13): His-Pro-Phe-His-Leu-Val-Ile-His (Leu-Val is the scissile bond).	Proline	179-182	angiotensinogen	Homo sapiens	139-154
3099113-2	1986	A species specific protein with repetitive -Gln-His-Pro-Gly- sequences, which are flanked on the N- and C-terminus by paired basic residues, has been shown to be the source of TRH in frog skin and rat hypothalamus.	Proline	52-55	thyrotropin releasing hormone	Rattus norvegicus	176-179
3320533-4	1987	PP12 is a 34-kDa glycoprotein, which has an N-terminal amino acid sequence of Ala-Pro-Trp-Gln-Cys-Ala-Pro-Cys-Ser-Ala.	Proline	82-85	insulin like growth factor binding protein 1	Homo sapiens	0-4
3320533-4	1987	PP12 is a 34-kDa glycoprotein, which has an N-terminal amino acid sequence of Ala-Pro-Trp-Gln-Cys-Ala-Pro-Cys-Ser-Ala.	Proline	102-105	insulin like growth factor binding protein 1	Homo sapiens	0-4
3104816-5	1987	The results are discussed with reference to the lack of specific binding sites in brain for the proposed neuropeptide and TRH metabolite cyclo(His-Pro).	Proline	147-150	thyrotropin releasing hormone	Rattus norvegicus	122-125
3025855-4	1987	The amino-terminal region appears to be divided into two subregions by a threonine- and proline-rich sequence of 23 amino acids that is highly conserved between Ly-1 and its human homologue Leu-1 (CD5) in position and amino acid composition.	Proline	88-95	CD5 antigen	Mus musculus	161-165
3025855-4	1987	The amino-terminal region appears to be divided into two subregions by a threonine- and proline-rich sequence of 23 amino acids that is highly conserved between Ly-1 and its human homologue Leu-1 (CD5) in position and amino acid composition.	Proline	88-95	CD5 molecule	Homo sapiens	190-195
3025855-4	1987	The amino-terminal region appears to be divided into two subregions by a threonine- and proline-rich sequence of 23 amino acids that is highly conserved between Ly-1 and its human homologue Leu-1 (CD5) in position and amino acid composition.	Proline	88-95	CD5 molecule	Homo sapiens	197-200
2877746-4	1986	In addition to the prd-specific his-pro repeat, some of the 12 genes contain M-repeats and two new types of homeo boxes not detectable by hybridization with the two known classes of homeo boxes.	Proline	36-39	paired	Drosophila melanogaster	19-22
3539636-2	1986	The peptides with X = N-Me-Ala, Sar and Ala as well as the standard substrate (X = Pro) were found to be good substrates, while those with X = alpha-aminobutyryl, Hyp, Ser and Gly were poor substrates, and those with X = pipecolyl, alpha-aminoisobutyryl, N-Me-Val, N-Me-Leu, Hyp(O-Bzl) and Ser(O-Bzl) were not cleaved at all.	Proline	83-86	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	275-278
3025664-10	1986	This sequence difference resulted in an arginine being coded for in clone p53-H-1 and a proline being coded for at the equivalent position in clone p53-H-19.	Proline	88-95	tumor protein p53	Homo sapiens	148-151
3782108-7	1986	However, even in this 30-residue long peptide there are significant differences between the proteins as the proline content of HMG-17 (8 residues) is twice that of HMG-14.	Proline	108-115	high mobility group nucleosomal binding domain 2	Homo sapiens	127-133
3571180-6	1986	Pro-197 was suggested to be the NH2-terminal boundary of the alpha-helical coiled-coil rod sequence of gizzard myosin, based on the homology with the nematode sequence reported by MacLachlan and Karn (Proc.	Proline	0-3	myosin, heavy chain 15	Gallus gallus	111-117
3026439-0	1986	Guanidine hydrochloride induced equilibrium unfolding of mutant forms of iso-1-cytochrome c with replacement of proline-71.	Proline	112-119	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	73-78
3538016-9	1986	This region had a high proline content in the progesterone receptor.	Proline	23-30	progesterone receptor	Oryctolagus cuniculus	46-67
3548222-3	1986	Epidermal growth factor (EGF), insulin, triiodothyronine (T3) and glucagon also enhanced the labeling of suckling rat hepatocytes regardless of the presence or the absence of L-proline.	Proline	175-184	epidermal growth factor like 1	Rattus norvegicus	0-23
3026440-0	1986	Folding/unfolding kinetics of mutant forms of iso-1-cytochrome c with replacement of proline-71.	Proline	85-92	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	46-51
3026439-1	1986	Proline-71, an evolutionally conserved residue that separates two short alpha-helical regions, is replaced by valine, threonine, or isoleucine in at least partially functional forms of iso-1-cytochrome c from Saccharomyces cerevisiae [Ernst, J. F., Hampsey, D. M., Stewart, J. W., Rackovsky, S., Goldstein, D., & Sherman, F. (1985) J. Biol.	Proline	0-7	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	185-190
3026440-1	1986	Proline-71, an evolutionally conserved residue that separates two short alpha-helical regions, is replaced by valine, threonine, or isoleucine in at least partially functional forms of iso-1-cytochrome c from Saccharomyces cerevisiae [Ernst, J. F., Hampsey, D. M., Stewart, J. W., Rackovsky, S., Goldstein, D., & Sherman, F. (1985) J. Biol.	Proline	0-7	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	185-190
3025596-1	1986	delta 1-Pyrroline-5-carboxylate (P5C) dehydrogenase, the second enzyme in the proline utilization (Put) pathway of Saccharomyces cerevisiae and the product of the PUT2 gene, was localized to the matrix compartment by a mitochondrial fractionation procedure.	Proline	78-85	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	163-167
3532956-9	1986	Human prothymosin alpha also differs from rat prothymosin alpha at positions corresponding to residues 87, 92, and 102 of the latter, with substitutions of alanine for proline, alanine for valine, and aspartic acid for glutamic acid, respectively.	Proline	168-175	prothymosin alpha pseudogene 9	Homo sapiens	6-23
3536852-0	1986	Proline transport in Salmonella typhimurium: putP permease mutants with altered substrate specificity.	Proline	0-7	sodium/proline symporter	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	45-49
3536852-1	1986	The putP gene encodes a proline permease required for Salmonella typhimurium LT2 to grow on proline as the sole source of nitrogen.	Proline	24-31	sodium/proline symporter	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	4-8
3536852-2	1986	The wild-type strain is sensitive to two toxic proline analogs (azetidine-2-carboxylic acid and 3,4-dehydroproline) also transported by the putP permease.	Proline	47-54	sodium/proline symporter	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	140-144
3095143-0	1986	The single proline-glutamine substitution at position 5 enhances the potency of amyloid fibril formation of murine apo A-II.	Proline	11-18	apolipoprotein A-II	Mus musculus	115-123
3095143-4	1986	Substitution of glutamine (ASSAM) for proline (apo A-II) at position 5 is distinct and may possibly be related to murine senile amyloid-ogenesis.	Proline	38-45	apolipoprotein A-II	Mus musculus	47-55
3025596-9	1986	The expression of the longer hybrids had deleterious effects on cell growth; PUT2-lacZ366-containing strains failed to grow on proline as the sole source of nitrogen.	Proline	127-134	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	77-81
3763959-0	1986	Characterization of a camel milk protein rich in proline identifies a new beta-casein fragment.	Proline	49-56	beta-casein	Camelus bactrianus	74-85
24248199-1	1986	This paper reports that the opaque-6 (o6) mutation of maize, which causes seedling lethality and interferes in the endosperm with the synthesis of zeins and b-32 protein, is a proline requiring mutant functionally allelic to proline-1 (pro-1).	Proline	176-183	Ribosome-inactivating protein 9	Zea mays	28-36
24248199-1	1986	This paper reports that the opaque-6 (o6) mutation of maize, which causes seedling lethality and interferes in the endosperm with the synthesis of zeins and b-32 protein, is a proline requiring mutant functionally allelic to proline-1 (pro-1).	Proline	176-183	Ribosome-inactivating protein 9	Zea mays	38-40
24248199-1	1986	This paper reports that the opaque-6 (o6) mutation of maize, which causes seedling lethality and interferes in the endosperm with the synthesis of zeins and b-32 protein, is a proline requiring mutant functionally allelic to proline-1 (pro-1).	Proline	176-183	Ribosome-inactivating protein 9	Zea mays	157-161
24248199-1	1986	This paper reports that the opaque-6 (o6) mutation of maize, which causes seedling lethality and interferes in the endosperm with the synthesis of zeins and b-32 protein, is a proline requiring mutant functionally allelic to proline-1 (pro-1).	Proline	225-232	Ribosome-inactivating protein 9	Zea mays	28-36
24248199-1	1986	This paper reports that the opaque-6 (o6) mutation of maize, which causes seedling lethality and interferes in the endosperm with the synthesis of zeins and b-32 protein, is a proline requiring mutant functionally allelic to proline-1 (pro-1).	Proline	225-232	Ribosome-inactivating protein 9	Zea mays	38-40
24248199-1	1986	This paper reports that the opaque-6 (o6) mutation of maize, which causes seedling lethality and interferes in the endosperm with the synthesis of zeins and b-32 protein, is a proline requiring mutant functionally allelic to proline-1 (pro-1).	Proline	225-232	Ribosome-inactivating protein 9	Zea mays	157-161
24248199-1	1986	This paper reports that the opaque-6 (o6) mutation of maize, which causes seedling lethality and interferes in the endosperm with the synthesis of zeins and b-32 protein, is a proline requiring mutant functionally allelic to proline-1 (pro-1).	Proline	162-165	Ribosome-inactivating protein 9	Zea mays	28-36
24248199-1	1986	This paper reports that the opaque-6 (o6) mutation of maize, which causes seedling lethality and interferes in the endosperm with the synthesis of zeins and b-32 protein, is a proline requiring mutant functionally allelic to proline-1 (pro-1).	Proline	162-165	Ribosome-inactivating protein 9	Zea mays	38-40
24248199-1	1986	This paper reports that the opaque-6 (o6) mutation of maize, which causes seedling lethality and interferes in the endosperm with the synthesis of zeins and b-32 protein, is a proline requiring mutant functionally allelic to proline-1 (pro-1).	Proline	162-165	Ribosome-inactivating protein 9	Zea mays	157-161
3780669-10	1986	Contained within the first 106 amino acids of the mouse GR is a stretch of nine glutamines with two prolines which are related to the family of transcribed repetitive elements, opa, found in Drosophila melanogaster.	Proline	100-108	nuclear receptor subfamily 3, group C, member 1	Mus musculus	56-58
3015948-0	1986	A study of roles of evolutionarily invariant proline 30 and glycine 34 of cytochrome c.	Proline	45-52	cytochrome c, somatic	Equus caballus	74-86
2426658-4	1986	The structure of murine apo A-II cDNA is of interest because of the amino acid substitution found in ASSAM and serum apo A-II of SAM-P; in SAM-R or other random bred slc:ICR mice, amino acid residue 5 of mature apo A-II is proline but, in SAM-P, this amino acid is changed to glutamine.	Proline	223-230	apolipoprotein A-II	Mus musculus	24-32
3537723-0	1986	Proline utilization in Saccharomyces cerevisiae: analysis of the cloned PUT1 gene.	Proline	0-7	proline dehydrogenase	Saccharomyces cerevisiae S288C	72-76
3754992-5	1986	An internal hydrophobic domain and 90% of the proline residues found within the influenza A virus PB1 protein are conserved in the influenza B virus molecule.	Proline	46-53	polybromo 1	Homo sapiens	98-101
3711077-3	1986	The present study investigates the question whether the pro-S hydrogen at C-4" of PMP is labilized by its active site environment independently of the formation of the ketimine intermediate, i.e. in the absence of substrate.	Proline	56-61	complement 4	Gallus gallus	74-77
3755524-6	1986	An examination of the amino acid sequence indicates that the RP2 protein is proline-rich and is composed of alternating alpha-helix and beta-sheet regions.	Proline	76-83	retinitis pigmentosa 2 homolog	Mus musculus	61-64
3711098-5	1986	The amino acid composition of gpL115 has several atypical features including low lysine content, high proline content, and very high content of hydroxyamino acids (12.5 residues of serine and 12.5 residues of threonine/100 amino acids).	Proline	102-109	sialophorin	Homo sapiens	30-36
3537723-8	1986	Approximately 50-fold more PUT1-specific mRNA was detected in induced (proline-grown) cells than in uninduced (ammonia-grown) cells.	Proline	71-78	proline dehydrogenase	Saccharomyces cerevisiae S288C	27-31
2424019-3	1986	Parallel in vitro studies show that TGF-beta causes marked increase of either proline or leucine incorporation into collagen in either an NRK rat fibroblast cell line or early passage human dermal fibroblasts.	Proline	78-85	transforming growth factor, beta 1	Rattus norvegicus	36-44
2940368-0	1986	Potent vasopressin antagonists lacking the proline residue at position 7.	Proline	43-50	arginine vasopressin	Homo sapiens	7-18
2482748-0	1986	One- and two-dimensional 1H NMR study of the substance P fragment ARG-PRO-Lys-Pro.	Proline	70-73	tachykinin precursor 1	Homo sapiens	45-56
2482748-0	1986	One- and two-dimensional 1H NMR study of the substance P fragment ARG-PRO-Lys-Pro.	Proline	78-81	tachykinin precursor 1	Homo sapiens	45-56
2424019-6	1986	These activated media markedly stimulate proline incorporation into collagen in NRK cells; this effect is blocked by a specific antibody to TGF-beta.	Proline	41-48	transforming growth factor beta 1	Homo sapiens	140-148
3088682-2	1986	Peptides related to thyrotropin releasing hormone (TRH) were identified in the eluted fractions by trypsin digestion and radioimmunoassay (RIA) using antibodies to the TRH tripeptide pGlu-His-Pro amide or to a TRH-related pentapeptide pGlu-His-Pro-Gly-Lys.	Proline	192-195	thyrotropin-releasing hormone L homeolog	Xenopus laevis	20-49
3755044-4	1986	Proline and leucine were identified in the P2 and P1 positions of the protease cleavage site, providing a possible explanation for the ability of heparin cofactor II to inhibit both thrombin and chymotrypsin-like proteases.	Proline	0-7	inorganic pyrophosphatase 1	Homo sapiens	43-52
3755044-4	1986	Proline and leucine were identified in the P2 and P1 positions of the protease cleavage site, providing a possible explanation for the ability of heparin cofactor II to inhibit both thrombin and chymotrypsin-like proteases.	Proline	0-7	coagulation factor II, thrombin	Homo sapiens	182-190
2873157-3	1986	Especially, the release of proline increases drastically from almost zero to the theoretical amount in the presence of DP IV.	Proline	27-34	dipeptidyl peptidase 4	Bos taurus	119-124
3521730-1	1986	The complete amino acid sequences of two basic proline-rich proteins, IB-1 and IB-6, from human parotid saliva have been determined.	Proline	47-54	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	70-83
3521730-4	1986	IB-1 and IB-6 contain an identical sequence of 54 residues except for an alanine in position 52 of IB-6, where IB-1 has proline.	Proline	120-127	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	0-4
3521730-4	1986	IB-1 and IB-6 contain an identical sequence of 54 residues except for an alanine in position 52 of IB-6, where IB-1 has proline.	Proline	120-127	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	111-115
3088682-2	1986	Peptides related to thyrotropin releasing hormone (TRH) were identified in the eluted fractions by trypsin digestion and radioimmunoassay (RIA) using antibodies to the TRH tripeptide pGlu-His-Pro amide or to a TRH-related pentapeptide pGlu-His-Pro-Gly-Lys.	Proline	192-195	thyrotropin-releasing hormone L homeolog	Xenopus laevis	51-54
3088682-5	1986	Evidence was also obtained for the presence of small amounts of the TRH-related pentapeptide pGlu-His-Pro-Gly-Lys.	Proline	102-105	thyrotropin-releasing hormone L homeolog	Xenopus laevis	68-71
3957924-3	1986	The low molecular weight polysialoglycoprotein obtained from the fertilized eggs accounted for about 85% of total polysialoglycoprotein and comprised glycotridecapeptides with a uniform peptide sequence which was determined to be Asp-Asp-Ala-Thr*-Ser*-Glu-Ala-Ala-Thr*-Gly-Pro-Ser-Gly, where * indicates the site of glycosylation.	Proline	273-276	polysialoglycoprotein	Oncorhynchus mykiss	25-46
3735806-6	1986	Its biological activities were equipotent to those of bovine NT, suggesting the presence of proline in the COOH-terminal hexapeptide.	Proline	92-99	neurotensin	Bos taurus	61-63
3944104-14	1986	However, the proline-rich carboxyl-terminal region of the A-chain displays some sequence similarity to collagens and the collagen-like domains of complement subcomponent C1q.	Proline	13-20	complement C1q A chain	Homo sapiens	170-173
2422658-2	1986	The interaction of these thymocytes with fibronectin could be inhibited by the synthetic peptide Gly-Arg-Gly-Asp-Ser-Pro, which comprises the previously identified cell-attachment determinant of the molecule, suggesting that the cell attachment site on fibronectin is recognized by these cells.	Proline	117-120	fibronectin 1	Homo sapiens	41-52
2422658-2	1986	The interaction of these thymocytes with fibronectin could be inhibited by the synthetic peptide Gly-Arg-Gly-Asp-Ser-Pro, which comprises the previously identified cell-attachment determinant of the molecule, suggesting that the cell attachment site on fibronectin is recognized by these cells.	Proline	117-120	fibronectin 1	Homo sapiens	253-264
3785163-5	1986	Its 3" end mapped to a site 187 nucleotides from the 5" end of the proline tRNA gene.	Proline	67-74	mitochondrially encoded tRNA glycine	Homo sapiens	75-79
2423824-4	1986	Comparing the structure-activity relationships of the peptides, the amino acid sequence Arg-Pro at the N-terminal region of bradykinin and substance P or Pro-Arg at the C-terminal part of tuftsin and rigin appear to be responsible for the lymphokine secretion.	Proline	92-95	kininogen 1	Homo sapiens	124-134
2867104-3	1986	In the rabbit reticulocyte lysate cell-free translation system, total poly(A+) RNA from the tumor as well as that from bovine parathyroid glands directed the translation of a product which was specifically precipitated by an anti-PTH serum and which migrated at the same position as pre-pro-PTH on sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Proline	175-178	parathyroid hormone	Bos taurus	230-233
2867104-3	1986	In the rabbit reticulocyte lysate cell-free translation system, total poly(A+) RNA from the tumor as well as that from bovine parathyroid glands directed the translation of a product which was specifically precipitated by an anti-PTH serum and which migrated at the same position as pre-pro-PTH on sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Proline	175-178	parathyroid hormone	Bos taurus	291-294
3511911-1	1986	N-Benzyloxycarbonyl-Gly-Pro-diazomethyl ketone (Z-Gly-Pro-CHN2) was synthesized and tested as inhibitor of the post proline cleaving enzyme from bovine brain.	Proline	116-123	chimerin 2	Bos taurus	58-62
3511911-4	1986	Thus, Z-Gly-Pro-CHN2 seems to be an active site directed, specific inhibitor of post proline cleaving enzyme.	Proline	85-92	chimerin 2	Rattus norvegicus	16-20
3510558-8	1986	For isoleucine and proline, the insulin levels required for a half-maximal response were less than for glucose disposal (P less than 0.05), but, for all other insulin-influenced AA, the levels required were similar to those for glucose disposal.	Proline	19-26	insulin	Homo sapiens	32-39
3079917-3	1986	This protein contained five copies of the sequence Gln-His-Pro-Gly flanked by paired basic amino acids and could therefore generate five TRH molecules.	Proline	59-62	thyrotropin releasing hormone	Rattus norvegicus	137-140
3544718-2	1986	However, post proline cleaving enzyme (PPCE; EC 3.4.21.26), a proline specific endopeptidase which specifically hydrolyzes internal peptide bonds on the carboxyl side of proline residues, has been shown to inactivate numerous vasoactive peptides including angiotensins, kinins, substance P, vasopressin and oxytocin.	Proline	14-21	prolyl endopeptidase	Homo sapiens	39-43
3544718-2	1986	However, post proline cleaving enzyme (PPCE; EC 3.4.21.26), a proline specific endopeptidase which specifically hydrolyzes internal peptide bonds on the carboxyl side of proline residues, has been shown to inactivate numerous vasoactive peptides including angiotensins, kinins, substance P, vasopressin and oxytocin.	Proline	14-21	tachykinin precursor 1	Homo sapiens	278-289
3544718-2	1986	However, post proline cleaving enzyme (PPCE; EC 3.4.21.26), a proline specific endopeptidase which specifically hydrolyzes internal peptide bonds on the carboxyl side of proline residues, has been shown to inactivate numerous vasoactive peptides including angiotensins, kinins, substance P, vasopressin and oxytocin.	Proline	14-21	arginine vasopressin	Homo sapiens	291-302
3544718-2	1986	However, post proline cleaving enzyme (PPCE; EC 3.4.21.26), a proline specific endopeptidase which specifically hydrolyzes internal peptide bonds on the carboxyl side of proline residues, has been shown to inactivate numerous vasoactive peptides including angiotensins, kinins, substance P, vasopressin and oxytocin.	Proline	62-69	prolyl endopeptidase	Homo sapiens	9-37
3544718-2	1986	However, post proline cleaving enzyme (PPCE; EC 3.4.21.26), a proline specific endopeptidase which specifically hydrolyzes internal peptide bonds on the carboxyl side of proline residues, has been shown to inactivate numerous vasoactive peptides including angiotensins, kinins, substance P, vasopressin and oxytocin.	Proline	62-69	prolyl endopeptidase	Homo sapiens	39-43
3544718-2	1986	However, post proline cleaving enzyme (PPCE; EC 3.4.21.26), a proline specific endopeptidase which specifically hydrolyzes internal peptide bonds on the carboxyl side of proline residues, has been shown to inactivate numerous vasoactive peptides including angiotensins, kinins, substance P, vasopressin and oxytocin.	Proline	62-69	tachykinin precursor 1	Homo sapiens	278-289
3544718-2	1986	However, post proline cleaving enzyme (PPCE; EC 3.4.21.26), a proline specific endopeptidase which specifically hydrolyzes internal peptide bonds on the carboxyl side of proline residues, has been shown to inactivate numerous vasoactive peptides including angiotensins, kinins, substance P, vasopressin and oxytocin.	Proline	62-69	arginine vasopressin	Homo sapiens	291-302
3485427-4	1986	Material specifically immunoabsorbed with Sepharose-anti-C1q antibody from a culture medium of cells that was metabolically labelled with [3H] proline or [35S] methionine demonstrated a polypeptide pattern identical with that of serum C1q on SDS/polyacrylamide-gel electrophoresis.	Proline	143-150	complement C1q A chain	Homo sapiens	57-60
2871693-2	1986	Proline was replaced by D- or L-pipecolic acid (D- or L-Pip), which analogues in turn were protected by benzoxy-carbonyl (Z) group.	Proline	0-7	prolactin induced protein	Rattus norvegicus	56-59
3484452-4	1986	Treatment with IL-1 at 0.01-1 U/ml for 24 h caused a small increase in the incorporation of [3H]proline into collagenase-digestible protein (CDP) and non-collagen protein (NCP).	Proline	96-103	cut-like homeobox 1	Rattus norvegicus	109-139
2945695-8	1986	Using pooled human E CR1, an amino acid composition was derived which revealed a relatively high proline content.	Proline	97-104	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	21-24
3484452-4	1986	Treatment with IL-1 at 0.01-1 U/ml for 24 h caused a small increase in the incorporation of [3H]proline into collagenase-digestible protein (CDP) and non-collagen protein (NCP).	Proline	96-103	cut-like homeobox 1	Rattus norvegicus	141-144
3091639-1	1986	A sensitive and specific enzyme-linked immunosorbent assay (ELISA) for human urokinase-type plasminogen activator (u-PA) and its inactive proenzyme (pro-u-PA) was developed.	Proline	138-141	plasminogen activator, urokinase	Homo sapiens	153-157
3091639-5	1986	The recovery of added pro-u-PA was greater than 95%.	Proline	22-25	plasminogen activator, urokinase	Homo sapiens	26-30
2416809-4	1986	Although the fine specificities of the reagent antisera differed, competitive inhibition analyses with intact MBP revealed a cross-reactive determinant involving residues 99-100 (Thr-Pro).	Proline	183-186	myelin basic protein	Homo sapiens	110-113
4062288-1	1985	The acylation of salivary mucin with fatty acids and its biosynthesis was investigated by incubating rat submandibular salivary gland cells with [3H]palmitic acid and [3H]proline.	Proline	171-178	solute carrier family 13 member 2	Rattus norvegicus	26-31
2999785-4	1985	The calculated amino acid composition of the peptide unique to subunit IIa indicates that subunit IIa contains a domain rich in serine, proline, threonine, and tyrosine.	Proline	136-143	ATPase, class II, type 9A	Mus musculus	98-101
4084535-1	1985	In an effort to further develop the technique of isomer-specific proteolysis, a number of proline-containing substrates were subjected to hydrolysis in the presence of chymotrypsin, trypsin, or prolidase.	Proline	90-97	peptidase D	Homo sapiens	194-203
3935272-5	1985	The unidirectional transport of TRH could not be saturated with unlabelled TRH at a concentration as high as 10 mM, but was markedly reduced by 10 mM proline and by the inhibitor of amidase and aminopeptidase activity, bacitracin (2 mM).	Proline	150-157	thyrotropin releasing hormone	Rattus norvegicus	32-35
4091813-7	1985	The proline residues are in the trans configuration, consistent with an earlier study suggesting a beta-turn-rich structure.	Proline	4-11	amyloid beta precursor protein	Homo sapiens	97-103
3002750-10	1985	It was concluded that the substitution of proline amide, for proline thioamide group in TRH molecule did not change binding affinity to receptors in the central nervous system, but decreased biological effectiveness in CNS and substantially decreased the resistance to degradation in human and rat plasma.	Proline	42-49	thyrotropin releasing hormone	Rattus norvegicus	88-91
2999785-4	1985	The calculated amino acid composition of the peptide unique to subunit IIa indicates that subunit IIa contains a domain rich in serine, proline, threonine, and tyrosine.	Proline	136-143	ATPase, class II, type 9A	Mus musculus	71-74
3935636-6	1985	A 3- to 23-fold increase in His-Pro diketopiperazine levels occurred after 4 hours at 37 C. This was not due primarily to enzymatic removal of the pyroglutamyl residue from TRH by pyroglutamate aminopeptidase, since about 1 hour after ejaculation the initial His-Pro diketopiperazine levels were 9.7 +/- 5.1 micrograms/ml, or approximately 1000-fold greater than the corresponding levels of seminal TRH.	Proline	32-35	thyrotropin releasing hormone	Homo sapiens	399-402
3003303-6	1985	The minimal substrate for renin has the sequence: His-Pro-Phe-His-Leu-Val-Tyr.	Proline	54-57	renin	Homo sapiens	26-31
2997158-0	1985	Substitutions of proline 76 in yeast iso-1-cytochrome c. Analysis of residues compatible and incompatible with folding requirements.	Proline	17-24	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	37-42
2997158-4	1985	Specific activities of the altered iso-1-cytochromes c were estimated in vivo by growth of the strains in lactate medium; compared to normal iso-1-cytochrome c with Pro-76, the following activities were associated with the following replacements: approximately 90% for Val-76, approximately 60% for Thr-76, approximately 30% for Ser-76, approximately 20% for Ile-76, and 0% for Leu-76.	Proline	165-168	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	35-40
2997158-4	1985	Specific activities of the altered iso-1-cytochromes c were estimated in vivo by growth of the strains in lactate medium; compared to normal iso-1-cytochrome c with Pro-76, the following activities were associated with the following replacements: approximately 90% for Val-76, approximately 60% for Thr-76, approximately 30% for Ser-76, approximately 20% for Ile-76, and 0% for Leu-76.	Proline	165-168	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	141-146
3910310-13	1985	Arterial smooth muscle cells increase their uptake of elastin precursors (particularly proline) when subjected to intermittent distension (Leung et al, 1976) and this may form a common link in the changes generated in vascular and colonic muscle tissue with time.	Proline	87-94	elastin	Homo sapiens	54-61
2415158-0	1985	Structure and function of the proline-rich region of myelin basic protein.	Proline	30-37	myelin basic protein	Bos taurus	53-73
3929378-1	1985	A rabbit antiserum to a peptide sequence present in the precursor for thyrotropin-releasing hormone (proTRH), deduced from cloned amphibian-skin complementary DNA, was raised by immunization with the synthetic decapeptide Cys-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-Cys (proTRH-SH).	Proline	242-245	thyrotropin releasing hormone	Rattus norvegicus	70-99
4054942-2	1985	The product was covalently coupled to a nonimmunogenic oligopeptide, representing an extracytoplasmic sequence of the receptor for the epidermal growth factor (EGF-R amino acids 516-529: Asn-Leu-Leu-Glu-Gly-Glu-Pro-Arg-Glu-Phe-Val-Glu-Asn-Ser).	Proline	211-214	epidermal growth factor	Mus musculus	135-158
4054942-2	1985	The product was covalently coupled to a nonimmunogenic oligopeptide, representing an extracytoplasmic sequence of the receptor for the epidermal growth factor (EGF-R amino acids 516-529: Asn-Leu-Leu-Glu-Gly-Glu-Pro-Arg-Glu-Phe-Val-Glu-Asn-Ser).	Proline	211-214	epidermal growth factor receptor	Mus musculus	160-165
2931303-6	1985	Treatment of diabetic rats with GH for 10 days further increased both proline and hydroxyproline specific activities when compared either to diabetic or normal rats treated with GH.	Proline	70-77	gonadotropin releasing hormone receptor	Rattus norvegicus	32-34
2991265-8	1985	Both lung and brain ACE cleave Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (substance P) via two pathways.	Proline	35-38	angiotensin I converting enzyme	Rattus norvegicus	20-23
2415158-3	1985	We have examined the conformation of this proline-rich region using principally 13C nuclear magnetic resonance spectroscopy (125 MHz) both in intact bovine MBP and in several MBP fragment peptides which we synthesized, including octapeptide 97-104 (Arg-Thr-Pro-Pro-Pro-Ser-Gln-Gly).	Proline	42-49	myelin basic protein	Bos taurus	156-159
2415158-3	1985	We have examined the conformation of this proline-rich region using principally 13C nuclear magnetic resonance spectroscopy (125 MHz) both in intact bovine MBP and in several MBP fragment peptides which we synthesized, including octapeptide 97-104 (Arg-Thr-Pro-Pro-Pro-Ser-Gln-Gly).	Proline	42-49	myelin basic protein	Bos taurus	175-178
2415158-5	1985	Comparison with the 13C spectrum of intact MBP (125 MHz) suggested that the proline-rich region, as well as all other X-Pro MBP peptide junctures, was also essentially all trans in aqueous solution.	Proline	76-83	myelin basic protein	Bos taurus	43-46
4027221-2	1985	Sequence analysis of the peptides isolated from the H2A-H2B dimer formed in solution and in nuclei demonstrated that both dimers are produced through the covalent linkage of Tyr-40 of H2B and Pro-26 of H2A.	Proline	192-195	H2A clustered histone 18	Homo sapiens	52-55
4052039-3	1985	Pulse-chase experiments in which the synthesis and secretion of tropoelastin by artery cells were monitored demonstrated that, after a pulse with [3H]proline, the polypeptides rapidly appeared in the medium and the half-time of tropoelastin secretion was approx.	Proline	150-157	elastin	Gallus gallus	64-76
2993365-13	1985	Analysis of [3H]proline-labeled medium by SDS polyacrylamide gel electrophoresis showed that gamma interferon decreased the synthesis of type I and III collagens and fibronectin by adherent synovial cells in a dose-dependent manner.	Proline	16-23	fibronectin 1	Homo sapiens	166-177
3926517-2	1985	injection of histidyl-proline diketopiperazine [cyclo (His-Pro)], an active metabolite of thyrotropin-releasing hormone (TRH) in mice produced an antinociceptive effect in a dose-dependent manner as measured in four antinociceptive tests; tail-pressure, tail-flick, hot-plate and acetic acid writhing.	Proline	59-62	thyrotropin releasing hormone	Mus musculus	90-119
3926517-2	1985	injection of histidyl-proline diketopiperazine [cyclo (His-Pro)], an active metabolite of thyrotropin-releasing hormone (TRH) in mice produced an antinociceptive effect in a dose-dependent manner as measured in four antinociceptive tests; tail-pressure, tail-flick, hot-plate and acetic acid writhing.	Proline	59-62	thyrotropin releasing hormone	Mus musculus	121-124
3923480-6	1985	However, we find that proline, unlike these residues but like glycine, at position 12 causes helix termination at positions 11 and 12, a result that suggests that the p21 protein product with proline at position 12 may exhibit lowered transforming potential, in agreement with the results of recent genetic recombination experiments.	Proline	22-29	H3 histone pseudogene 16	Homo sapiens	167-170
3923480-6	1985	However, we find that proline, unlike these residues but like glycine, at position 12 causes helix termination at positions 11 and 12, a result that suggests that the p21 protein product with proline at position 12 may exhibit lowered transforming potential, in agreement with the results of recent genetic recombination experiments.	Proline	192-199	H3 histone pseudogene 16	Homo sapiens	167-170
3996584-6	1985	It is concluded that the recently described, highest Mr amelogenin of Mr = 26 000-30 000 is not a new component but is identical to the proline-rich components having relative molecular masses ranging from 15 000 to 18 000 described much earlier by several groups of workers.	Proline	136-143	amelogenin, X isoform	Bos taurus	56-66
4018266-5	1985	The N-terminal of native CoA synthase is proline, and proteolysis exposes glycine as a second N-terminal.	Proline	41-48	Coenzyme A synthase	Sus scrofa	25-37
4017950-13	1985	Our findings indicate that parenteral administration of thyroid hormones specifically increased (compared to transport of L-proline) the capacity of Na+ gradient-dependent renal BBM Pi uptake in Hyp mice, decreased renal Pi excretion, and increased plasma Pi.	Proline	122-131	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	195-198
4018721-0	1985	A comparison of stimulation of proline incorporation by human growth hormone and a two-chain modification.	Proline	31-38	growth hormone 1	Homo sapiens	62-76
2985590-4	1985	Our results and the results from the literature search suggest that the aminopeptidase cleaves amino-terminal methionine when it precedes residues of alanine, glycine, proline, serine, threonine, and valine but not when it precedes residues of arginine, asparagine, aspartic acid, glutamine glutamic acid, isoleucine, leucine, lysine, or methionine.	Proline	168-175	aminopeptidase	Saccharomyces cerevisiae S288C	72-86
4027221-2	1985	Sequence analysis of the peptides isolated from the H2A-H2B dimer formed in solution and in nuclei demonstrated that both dimers are produced through the covalent linkage of Tyr-40 of H2B and Pro-26 of H2A.	Proline	192-195	H2B clustered histone 21	Homo sapiens	56-59
2985598-8	1985	A striking feature of the alpha 2(V) sequence between 918-944 is the absence of proline residues.	Proline	80-87	collagen type V alpha 2 chain	Homo sapiens	26-36
4027221-2	1985	Sequence analysis of the peptides isolated from the H2A-H2B dimer formed in solution and in nuclei demonstrated that both dimers are produced through the covalent linkage of Tyr-40 of H2B and Pro-26 of H2A.	Proline	192-195	H2A clustered histone 18	Homo sapiens	202-205
4027221-4	1985	We conclude that the precise juxtaposition of Tyr-40 of H2B and Pro-26 of H2A in this region of the H2A/H2B contact site is not altered upon interaction of these histones with H3 and H4 (tetramer), DNA, or other chromosomal components during nucleosome assembly.	Proline	64-67	H2A clustered histone 18	Homo sapiens	74-77
4027221-4	1985	We conclude that the precise juxtaposition of Tyr-40 of H2B and Pro-26 of H2A in this region of the H2A/H2B contact site is not altered upon interaction of these histones with H3 and H4 (tetramer), DNA, or other chromosomal components during nucleosome assembly.	Proline	64-67	H2A clustered histone 18	Homo sapiens	100-103
4027221-4	1985	We conclude that the precise juxtaposition of Tyr-40 of H2B and Pro-26 of H2A in this region of the H2A/H2B contact site is not altered upon interaction of these histones with H3 and H4 (tetramer), DNA, or other chromosomal components during nucleosome assembly.	Proline	64-67	H2B clustered histone 21	Homo sapiens	104-107
3887901-6	1985	The minimal substrate for renin has the sequence: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Proline	54-57	renin	Homo sapiens	26-31
2859191-6	1985	By gel filtration S-14 LI was resolved into three peaks corresponding to S-14, S-28, and a higher mol wt form (14,000) corresponding to pro-S.	Proline	136-139	thyroid hormone responsive	Rattus norvegicus	18-22
3977840-6	1985	Amino acid analyses were in close agreement with previous reports, and showed BLPI to be rich in proline and cystine, but lacking histidine.	Proline	97-104	secretory leukocyte peptidase inhibitor	Homo sapiens	78-82
2578950-3	1985	Treatment with vanadate at 10 microM for 24 h or at 0.3-1 microM for 96 h increased the incorporation of [3H]proline into collagenase-digestible protein (CDP), but the effect was not specific for collagen; vanadate also increased the labeling of noncollagen protein (NCP).	Proline	109-116	cut-like homeobox 1	Rattus norvegicus	122-152
2578950-3	1985	Treatment with vanadate at 10 microM for 24 h or at 0.3-1 microM for 96 h increased the incorporation of [3H]proline into collagenase-digestible protein (CDP), but the effect was not specific for collagen; vanadate also increased the labeling of noncollagen protein (NCP).	Proline	109-116	cut-like homeobox 1	Rattus norvegicus	154-157
4096904-2	1985	Protamines are mixtures of basic proteins consisting of only seven types of amino acids (Arg, Ile, Val, Ser, Pro, Ala, and Gly), arginine (codon, AGR and CGN) being abundant.	Proline	0-3	cingulin	Homo sapiens	154-157
3967052-3	1985	The 120% increase in radiolabeling of collagen with [3H]proline by 10 nM somatomedin C was not due to changes in the rate of [3H]proline uptake.	Proline	56-63	insulin like growth factor 1	Homo sapiens	73-86
3920663-0	1985	Intraventricular administration of cyclo(His-Pro), a metabolite of thyrotropin-releasing hormone (TRH), decreases water intake in the rat.	Proline	45-48	thyrotropin releasing hormone	Rattus norvegicus	67-96
3920663-0	1985	Intraventricular administration of cyclo(His-Pro), a metabolite of thyrotropin-releasing hormone (TRH), decreases water intake in the rat.	Proline	45-48	thyrotropin releasing hormone	Rattus norvegicus	98-101
3986189-0	1985	The histidine-rich glycoprotein of serum has a domain rich in histidine, proline, and glycine that binds heme and metals.	Proline	73-80	histidine rich glycoprotein	Homo sapiens	4-31
3922011-5	1985	Areas of human postmortem brain appear to contain two of the enzymes capable of degrading TRH, a proline endopeptidase forming TRH-OH and a pyroglutamyl aminopeptidase forming cyclo(His-Pro).	Proline	186-189	thyrotropin releasing hormone	Homo sapiens	90-93
3919705-1	1985	Vasopressin stimulated gluconeogenesis from proline in hepatocytes from starved rats; this was attributed to an activation of oxoglutarate dehydrogenase (EC 1.2.4.2) [Staddon & McGivan (1984) Biochem.	Proline	44-51	arginine vasopressin	Rattus norvegicus	0-11
3930838-11	1985	The sepiapterin reductase catalyzed the transfer of the pro-S hydrogen of NADPH during the reduction of sepiapterin to BH2.	Proline	56-61	sepiapterin reductase	Homo sapiens	4-25
3881277-4	1985	In the amino acid sequence predicted by the IGF-II variant cDNA, the Ser residue 29 in the B-domain has been replaced by an Arg-Leu-Pro-Gly sequence.	Proline	132-135	insulin like growth factor 2	Homo sapiens	44-50
2939322-7	1985	A mutant defective in ATPase does not accumulate exogenously supplied nicotinic acid when lactate is used as an energy source, although L-proline, the transport of which is independent of ATP production, is accumulated.	Proline	136-145	ATPase	Escherichia coli	22-28
6501302-5	1984	The results indicate that DARPP-32 is phosphorylated at a single threonine residue contained in the sequence Arg-Arg-Arg-Pro-Thr(P)-Pro-Ala-Met-Leu-Phe-Arg.	Proline	121-124	protein phosphatase 1 regulatory inhibitor subunit 1B	Homo sapiens	26-34
3920737-5	1985	Cyclo(His-Pro) concentrations in the whole brain were significantly greater in the LPD group than in the pair-fed and ad libitum groups, whereas its concentrations were similar in the pair-fed and ad libitum groups.	Proline	10-13	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	83-86
6098824-0	1984	Primary structure of the nuclear PUT2 gene involved in the mitochondrial pathway for proline utilization in Saccharomyces cerevisiae.	Proline	85-92	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	33-37
6150137-6	1984	Elastin is composed largely of glycine, proline, and other hydrophobic residues and contains multiple lysine-derived cross-links, such as the desmosines, which link the individual polypeptide chains into a rubber-like network.	Proline	40-47	elastin	Homo sapiens	0-7
6089895-9	1984	The coupling constants for the hydroxyl free radical adduct of proline are AN = 1.58 mT, AH1 beta = AH2 beta = 2.13 mT, AH3 beta = 1.77 mT and for hydroxyproline are AN = 1.54 mT, AH1 beta = 2.56 mT, AH2 beta = 2.03 and AH3 beta = 1.51.	Proline	63-70	zinc finger RANBP2-type containing 3	Homo sapiens	100-103
6092966-5	1984	Analysis of rat fibroblasts transfected with these altered genes demonstrates that all amino acids except glycine (which is encoded by normal cellular ras genes) and proline at position 12 activate p21, suggesting a requirement for an alpha-helical structure in this region of the polypeptide.	Proline	166-173	KRAS proto-oncogene, GTPase	Rattus norvegicus	198-201
6152335-0	1984	Similarities of the substrate cleavage catalyzed by proline specific endopeptidase and dipeptidyl peptidase IV.	Proline	52-59	dipeptidyl peptidase 4	Homo sapiens	87-110
6089895-9	1984	The coupling constants for the hydroxyl free radical adduct of proline are AN = 1.58 mT, AH1 beta = AH2 beta = 2.13 mT, AH3 beta = 1.77 mT and for hydroxyproline are AN = 1.54 mT, AH1 beta = 2.56 mT, AH2 beta = 2.03 and AH3 beta = 1.51.	Proline	63-70	zinc finger RANBP2-type containing 3	Homo sapiens	200-203
6091059-5	1984	From the nucleotide sequence, nascent rat myosin light chain 2 is predicted to have Met Ala preceding Pro at the N-terminal end.	Proline	102-105	myosin light chain 2	Rattus norvegicus	42-62
6493639-2	1984	Proline also encourages a beta-conformation for the peptide chain presenting the terminal residues in a suitable conformation to form an abnormally large chelate ring.	Proline	0-7	amyloid beta precursor protein	Homo sapiens	24-30
6747630-3	1984	The time-dependent incorporation of [3H]proline into newly synthesized angiotensin II-like peptide was measured by radioimmunoassay using specific angiotensin II antisera.	Proline	40-47	angiotensinogen	Rattus norvegicus	71-85
6747630-3	1984	The time-dependent incorporation of [3H]proline into newly synthesized angiotensin II-like peptide was measured by radioimmunoassay using specific angiotensin II antisera.	Proline	40-47	angiotensinogen	Rattus norvegicus	147-161
6383346-3	1984	Pulse-chase experiments with cells labelled with [3H]proline established that newly synthesized tropoelastin polypeptides were associated solely with membrane-bound particulate fractions.	Proline	53-60	elastin	Gallus gallus	96-108
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Proline	111-114	renin	Homo sapiens	0-5
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Proline	111-114	renin	Homo sapiens	33-38
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Proline	111-114	angiotensinogen	Homo sapiens	68-83
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Proline	111-114	renin	Homo sapiens	161-166
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Proline	111-114	cathepsin D	Homo sapiens	196-207
6385771-1	1984	A synthetic tetradecapeptide, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, which corresponds to the 13 amino terminal residues of human angiotensinogen plus a carboxy terminal serine to replace a suggested site of carbohydrate attachment, has been shown to be a good substrate for human kidney renin.	Proline	56-59	angiotensinogen	Homo sapiens	153-168
6385771-1	1984	A synthetic tetradecapeptide, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, which corresponds to the 13 amino terminal residues of human angiotensinogen plus a carboxy terminal serine to replace a suggested site of carbohydrate attachment, has been shown to be a good substrate for human kidney renin.	Proline	56-59	renin	Homo sapiens	311-316
6380499-2	1984	Calculations and comparison of low energy structures for these peptides give support to the existence of a beta-turn-like structure involving the His-Pro-Phe-His region of the renin substrate and of the competitive inhibitors containing that sequence.	Proline	150-153	renin	Homo sapiens	176-181
6383346-5	1984	When rough-microsomal fractions, isolated from cells labelled with [3H]proline for 10 min, were treated with proteinases in the presence and in the absence of detergent, the nascent tropoelastin polypeptides were shown to be susceptible to proteolysis only when the integrity of the membranes was destroyed by detergent treatment.	Proline	71-78	elastin	Gallus gallus	182-194
6099385-6	1984	The minimal substrate for renin has the sequence: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Proline	54-57	renin	Homo sapiens	26-31
6147373-2	1984	In this method, the incubation is terminated by raising the pH of incubation mixture to 10, and [14C]pyrroline 5-carboxylate produced from the substrate, [14C]glutamate, is first converted quantitatively to [14C]proline by reduction with NaBH4 at pH 10 and then the proline is allowed to pass through column of AG1-X8 anion exchanger under the conditions where the glutamate is completely retained by the column.	Proline	212-219	NBPF member 10	Homo sapiens	311-314
6736134-4	1984	The proportion of fibronectin increased to 13.1% at 10(-7) M hydrocortisone, 15.5% at 10(-6) M and to 19.4% at 10(-5) M. The proportion of fibronectin associated with the cell layer remained at 2-3% of total [3H]proline-labeled proteins and did not increase with hydrocortisone exposure.	Proline	212-219	fibronectin 1	Homo sapiens	139-150
6730860-5	1984	Vasopressin decreased the incorporation of [3H]proline slightly but the action of this hormone was significantly less than that of oxytocin.	Proline	47-54	arginine vasopressin	Homo sapiens	0-11
6327326-4	1984	These analogues retained a high binding affinity to the renal vasopressin receptor with apparent dissociation constants KD in the order proline less than sarcosine less than methylalanine .	Proline	136-143	arginine vasopressin	Rattus norvegicus	62-73
6427779-5	1984	The full sequence of chicken GnRH-II has been determined to be: pGlu-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-Gly-NH2.	Proline	97-100	mitochondrial ribosomal protein S26	Gallus gallus	29-36
6329265-1	1984	Conglutinin is a bovine plasma protein which is relatively large and asymmetric with elevated contents of glycine and, to some extent, proline.	Proline	135-142	conglutinin	Bos taurus	0-11
6714161-7	1984	The amino acid sequence of rat PP is Ala-Pro-Leu-Glu-Pro-Met-Tyr-Pro-Gly-Asp- Tyr-Ala-Thr-His-Glu-Gln-Arg-Ala-Gln-Tyr-Glu-Thr-Gln-Leu-Arg-Arg-Tyr-Ile- Asn-Thr-Leu-Thr-Arg-Pro-Arg-Tyr-NH2.	Proline	41-44	pancreatic polypeptide	Rattus norvegicus	31-33
6714161-7	1984	The amino acid sequence of rat PP is Ala-Pro-Leu-Glu-Pro-Met-Tyr-Pro-Gly-Asp- Tyr-Ala-Thr-His-Glu-Gln-Arg-Ala-Gln-Tyr-Glu-Thr-Gln-Leu-Arg-Arg-Tyr-Ile- Asn-Thr-Leu-Thr-Arg-Pro-Arg-Tyr-NH2.	Proline	53-56	pancreatic polypeptide	Rattus norvegicus	31-33
6201483-2	1984	We proposed that: 1) pyrroline-5-carboxylate is converted to proline by pyrroline-5-carboxylate reductase with concomitant oxidation of NADPH, 2) NADP+ augments glucose-6-phosphate dehydrogenase activity, and 3) production of ribose-5-phosphate via the pentose shunt is increased.	Proline	61-68	glucose-6-phosphate dehydrogenase	Homo sapiens	161-194
6373733-1	1984	Colicin V-treated Escherichia coli was inhibited in its capacity to carry out active transport of proline and was unable to generate a membrane potential.	Proline	98-105	Colicin V	Escherichia coli	0-9
6400059-6	1984	Two tryptic peptides, derived from p53 protein radiolabeled with either methionine or proline, were purified and the position of these labeled residues in the peptide was determined.	Proline	86-93	transformation related protein 53, pseudogene	Mus musculus	35-38
6327326-5	1984	In contrast, the affinity to the hepatic vasopressin receptor, which shares characteristics with vasopressor receptors, was drastically reduced with KD values being in the order proline much less than N- methylalanine less than sarcosine.	Proline	178-185	arginine vasopressin	Rattus norvegicus	41-52
6200480-6	1984	Five major proline-rich polypeptides were detected and one of these was shown to be the in vitro precursor of the major anionic macaque proline-rich protein (MPRP), which is the structural and functional counterpart of the major anionic proline-rich proteins in the parotid and submandibular secretions of man (Oppenheim, F.G., Offner, G.D., and Troxler, R.F.	Proline	11-18	complement component 4 binding protein alpha	Homo sapiens	136-156
6141793-0	1984	Distinct effects of glucagon and vasopressin on proline metabolism in isolated hepatocytes.	Proline	48-55	arginine vasopressin	Rattus norvegicus	33-44
6324136-6	1984	Identification of the proteolytic cleavage sites showed that EMC viral protease, p22, has cleavage specificity for gln-gly or gln-ser sequences with adjacent proline residues.	Proline	158-165	calcineurin like EF-hand protein 1	Homo sapiens	81-84
6373590-2	1984	Iva-His-Pro-Phe-His-Sta-Leu-Phe-NH2 is a new, potent, specific statine -containing renin inhibitor.	Proline	8-12	renin	Rattus norvegicus	83-88
6703705-1	1984	Hydrolyzates of tissues that had been labeled with [14C]proline often contain significant amounts of cis-4-hydroxy[14C]proline.	Proline	56-63	suppressor of cytokine signaling 6	Homo sapiens	101-106
6141793-8	1984	(4) The data suggest that activation of oxoglutarate dehydrogenase (EC 1.2.4.2) by glucagon and vasopressin by different mechanisms may explain the relative effects of the hormones alone and in combination on gluconeogenesis from proline.	Proline	230-237	oxoglutarate dehydrogenase	Rattus norvegicus	40-66
6141793-8	1984	(4) The data suggest that activation of oxoglutarate dehydrogenase (EC 1.2.4.2) by glucagon and vasopressin by different mechanisms may explain the relative effects of the hormones alone and in combination on gluconeogenesis from proline.	Proline	230-237	arginine vasopressin	Rattus norvegicus	96-107
6401122-7	1983	We believe that our observations on proline hydroxylation in collagen should also be applicable to C1q and acetylcholineesterase both of which share the general structural and functional properties of collagen in their "tail" regions.	Proline	36-43	complement C1q A chain	Homo sapiens	99-102
6696746-2	1984	The amino acid composition of this new species of tropoelastin is elastin-like in its high proportion of proline, glycine, alanine and valine.	Proline	105-112	elastin	Gallus gallus	50-62
6696746-4	1984	In addition, the amount of proline hydroxylation is 3 times higher than that found in chick tropoelastin b.	Proline	27-34	elastin	Gallus gallus	92-104
6099783-1	1984	The synthetic tetradecapeptide renin substrate (TDP; Asp-arg-val-tyr-ile-his-pro-phe-his-leu-leu-val-tyr-ser) has been employed frequently to elucidate the enzymatic action of renin in vitro and, to a lesser extent, in vivo.	Proline	77-80	renin	Rattus norvegicus	31-36
6424064-0	1983	Protein-energy malnutrition alters brain thyrotropin-releasing hormone and cyclo (His-Pro) in the neonatal rat.	Proline	0-3	thyrotropin releasing hormone	Rattus norvegicus	41-70
6358218-5	1983	L-Proline entered rat islet cells mainly by system A; L-leucine by the Na+-independent system L. The uptake of L-alanine, L-serine, and L-glutamine was shared by systems ASC and L, the participation of system A being negligible for these three amino acids.	Proline	0-9	PYD and CARD domain containing	Rattus norvegicus	170-173
6196232-6	1983	The minimal substrate for renin is an octapeptide segment of the protein substrate: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Proline	88-91	renin	Homo sapiens	26-31
6199318-1	1984	Substituting sarcosine or N-methylalanine for proline in the inhibitory vasopressin analogs dPAVP and d(CH2)5AVP had the following effects: 1) milk ejection and antidiuretic activities were severely depressed, 2) pressor antagonism was maintained but weakened somewhat, and 3) antagonism in the uterus in vitro was maintained, but no consistent pattern was seen.	Proline	46-53	arginine vasopressin	Homo sapiens	72-83
6358414-7	1984	Since prolyl endopeptidase readily degrades many proline-containing neuropeptides, the inhibitor should be of value in studies on the role of the enzyme in neuropeptide metabolism.	Proline	49-56	prolyl endopeptidase	Mus musculus	6-26
20488055-5	1984	opioid agonist, also acted as a substrate for the N-Tyr-MIF-1 converting enzyme with cleavage of the Tyr-Pro bond.	Proline	105-108	predicted gene 4924	Mus musculus	56-61
6142880-2	1983	Resonance Raman (RR) spectra were obtained in H2O or D2O solution for the purple intermediates of D-amino acid oxidase (DAO) with isotopically labeled substrates, i.e., [1-13C]-, [2-13C]-, [3-13C]-, [15N]-, and [3,3,3-D3]alanine; [carboxyl-13C]- and [15N]proline.	Proline	255-262	D-amino acid oxidase	Homo sapiens	98-118
6142880-2	1983	Resonance Raman (RR) spectra were obtained in H2O or D2O solution for the purple intermediates of D-amino acid oxidase (DAO) with isotopically labeled substrates, i.e., [1-13C]-, [2-13C]-, [3-13C]-, [15N]-, and [3,3,3-D3]alanine; [carboxyl-13C]- and [15N]proline.	Proline	255-262	D-amino acid oxidase	Homo sapiens	120-123
6358755-3	1983	This enzyme, highly active in brain and other tissues, catabolizes proline-containing peptides such as substance P, neurotensin, luteinizing hormone-releasing hormone, thyrotropin releasing hormone, bradykinin and angiotensin II.	Proline	67-74	tachykinin precursor 1	Homo sapiens	103-114
6358755-3	1983	This enzyme, highly active in brain and other tissues, catabolizes proline-containing peptides such as substance P, neurotensin, luteinizing hormone-releasing hormone, thyrotropin releasing hormone, bradykinin and angiotensin II.	Proline	67-74	neurotensin	Homo sapiens	116-127
6358755-3	1983	This enzyme, highly active in brain and other tissues, catabolizes proline-containing peptides such as substance P, neurotensin, luteinizing hormone-releasing hormone, thyrotropin releasing hormone, bradykinin and angiotensin II.	Proline	67-74	thyrotropin releasing hormone	Homo sapiens	129-197
6358755-3	1983	This enzyme, highly active in brain and other tissues, catabolizes proline-containing peptides such as substance P, neurotensin, luteinizing hormone-releasing hormone, thyrotropin releasing hormone, bradykinin and angiotensin II.	Proline	67-74	kininogen 1	Homo sapiens	199-209
6358755-3	1983	This enzyme, highly active in brain and other tissues, catabolizes proline-containing peptides such as substance P, neurotensin, luteinizing hormone-releasing hormone, thyrotropin releasing hormone, bradykinin and angiotensin II.	Proline	67-74	angiotensinogen	Homo sapiens	214-228
6359978-7	1983	Only proline correlated positively with insulin.	Proline	5-12	insulin	Canis lupus familiaris	40-47
6318849-8	1983	Vasopressin and angiotensin II also decreased lipogenesis and incorporation of 14C into fatty acids in glycogen-depleted hepatocytes provided with [U-14C]proline as opposed to [U-14C]-lactate.	Proline	154-161	arginine vasopressin	Rattus norvegicus	0-11
6415290-10	1983	Both proteins, particularly H-protein, have a high proline content.	Proline	51-58	glycine cleavage system H protein, mitochondrial	Oryctolagus cuniculus	28-37
6318849-8	1983	Vasopressin and angiotensin II also decreased lipogenesis and incorporation of 14C into fatty acids in glycogen-depleted hepatocytes provided with [U-14C]proline as opposed to [U-14C]-lactate.	Proline	154-161	angiotensinogen	Rattus norvegicus	16-30
6352261-6	1983	Several substitutions relative to bovine insulin occur in the proposed receptor binding region (A5Gln leads to His, B21Glu leads to Pro, B22Arg leads to Lys, B25Phe leads to Tyr).	Proline	132-135	insulin	Bos taurus	41-48
6194822-2	1983	Residues 67 to 75 in myelin basic protein from several species comprise the sequence Thr-His-Tyr-Gly-Ser-Leu-Pro-Gln-Lys that acts as an encephalitogenic determinant in the rabbit.	Proline	109-112	myelin basic protein	Oryctolagus cuniculus	21-41
6418650-9	1983	The minimal substrate for renin is an octapeptide segment of the protein substrate: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Proline	88-91	renin	Homo sapiens	26-31
6138350-1	1983	The high affinity, sodium-dependent uptake of proline by rat brain synaptosomes was inhibited by the opioid pentapeptides, Leu-enkephalin and Met-enkephalin.	Proline	46-53	proenkephalin	Rattus norvegicus	127-137
6138350-1	1983	The high affinity, sodium-dependent uptake of proline by rat brain synaptosomes was inhibited by the opioid pentapeptides, Leu-enkephalin and Met-enkephalin.	Proline	46-53	proenkephalin	Rattus norvegicus	146-156
6138350-4	1983	The extent of proline uptake was half-maximal at a Leu-enkephalin concentration of 1 microM.	Proline	14-21	proenkephalin	Rattus norvegicus	55-65
6138350-10	1983	A modified enkephalin ([D-Ser2]Leu-enkephalin-Thr) with selective affinity for the delta subclass of enkephalin receptor was effective in inhibiting proline uptake.	Proline	149-156	proenkephalin	Rattus norvegicus	11-21
6138350-10	1983	A modified enkephalin ([D-Ser2]Leu-enkephalin-Thr) with selective affinity for the delta subclass of enkephalin receptor was effective in inhibiting proline uptake.	Proline	149-156	proenkephalin	Rattus norvegicus	35-45
6138350-10	1983	A modified enkephalin ([D-Ser2]Leu-enkephalin-Thr) with selective affinity for the delta subclass of enkephalin receptor was effective in inhibiting proline uptake.	Proline	149-156	proenkephalin	Rattus norvegicus	35-45
6138350-11	1983	On the basis of the selectivity of these effects, we propose that there is a specific population of nerve endings in the cerebral cortex that contains both a proline-transport system and binding sites for Leu- and Met-enkephalin and furthermore, that these binding sites may be related to the putative delta receptor.	Proline	158-165	proenkephalin	Rattus norvegicus	218-228
6358862-0	1983	Proline utilization in Saccharomyces cerevisiae: analysis of the cloned PUT2 gene.	Proline	0-7	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	72-76
6626500-2	1983	The following peptide was synthesized by classical methods in solution: Ac-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg-Gly-Pro-Arg-Val-NHCH3 (F-8).	Proline	119-122	coagulation factor VIII	Homo sapiens	138-141
6617875-0	1983	Proline- and alanine-rich N-terminal extension of the basic bovine beta-crystallin B1 chains.	Proline	0-7	crystallin beta B1	Bos taurus	67-85
6351752-2	1983	The prolyl endopeptidase is apparently highly specific for cleaving peptides after proline residues.	Proline	83-90	prolyl endopeptidase	Mus musculus	4-24
6883163-7	1983	These are (formula; see text) These proline positions 4 and 8 are identical to those for NH2-terminal sequence for tropoelastin.	Proline	36-43	elastin	Gallus gallus	115-127
6193076-1	1983	The conformational behaviour of the basic hydrophilic Pro-Arg-Arg-Pro and Arg-Pro-Lys-Pro peptides, neurotensin (NT) and Substance P fragments, has been taken up by semi-empirical calculations.	Proline	54-57	neurotensin	Homo sapiens	100-111
6193076-1	1983	The conformational behaviour of the basic hydrophilic Pro-Arg-Arg-Pro and Arg-Pro-Lys-Pro peptides, neurotensin (NT) and Substance P fragments, has been taken up by semi-empirical calculations.	Proline	54-57	tachykinin precursor 1	Homo sapiens	121-132
6853532-7	1983	Comparison of the 27-residue peptide with the known structure of porcine gastrin-releasing peptide, another bombesin-like heptacosapeptide, reveals four amino acid substitutions: canine bombesin-like peptide had Pro 4, Gly 5, Gln 7, Asp 12, whereas porcine gastrin-releasing peptide had Ser 4, Val 5, Gly 7, Ala 12.	Proline	212-215	gastrin releasing peptide	Canis lupus familiaris	73-98
6345724-1	1983	Prolyl endopeptidase cleaves peptide bonds on the carboxyl side of proline residues within a peptide chain.	Proline	67-74	prolyl endopeptidase	Oryctolagus cuniculus	0-20
6189903-8	1983	The gene coding for P19 had two -Asp-Pro-connections.	Proline	37-40	interleukin 23 subunit alpha	Homo sapiens	20-23
6189903-9	1983	By splitting these connections in P19 and P15.5 preparations with formic acid, smaller polypeptides were obtained with sizes predicted from the nucleotide sequence and with the N-terminus amino acid of proline as expected.	Proline	202-209	interleukin 23 subunit alpha	Homo sapiens	34-37
6189903-9	1983	By splitting these connections in P19 and P15.5 preparations with formic acid, smaller polypeptides were obtained with sizes predicted from the nucleotide sequence and with the N-terminus amino acid of proline as expected.	Proline	202-209	cyclin dependent kinase inhibitor 2B	Homo sapiens	42-45
6303852-3	1983	BLV p12 is a proline-rich linear polypeptide composed of 69 amino acids with Mr 7558.	Proline	13-20	polymerase (DNA-directed), delta 4	Mus musculus	4-7
6347189-1	1983	A new affinity column for renin was prepared by coupling the isosteric peptide inhibitor of renin, H.77 (D-His-Pro-Phe-His-LeuR-Leu-Val-Tyr, where R is a reduced isosteric bond, -CH2-NH-), to activated 6-aminohexanoic acid-Sepharose 4B.	Proline	111-114	renin	Homo sapiens	26-31
6347189-1	1983	A new affinity column for renin was prepared by coupling the isosteric peptide inhibitor of renin, H.77 (D-His-Pro-Phe-His-LeuR-Leu-Val-Tyr, where R is a reduced isosteric bond, -CH2-NH-), to activated 6-aminohexanoic acid-Sepharose 4B.	Proline	111-114	renin	Homo sapiens	92-97
6834388-4	1983	Two proline derivatives, (4S)-1-butyryl-4-[(carboxymethyl)amino]-L-proline (9a) and its 1-benzoyl analogue (9b), were designed to interact, via ionic or hydrogen bonds, with polar residues beta His-2, beta Thr-4, and beta Lys-132 of hemoglobin S (HbS).	Proline	4-11	histatin 3	Homo sapiens	194-199
6435625-3	1983	In hepatocytes from fed rats, fatty acid and proline oxidation are stimulated in parallel by adrenaline, noradrenaline, vasopressin and angiotensin II.	Proline	45-52	arginine vasopressin	Rattus norvegicus	120-131
6435625-3	1983	In hepatocytes from fed rats, fatty acid and proline oxidation are stimulated in parallel by adrenaline, noradrenaline, vasopressin and angiotensin II.	Proline	45-52	angiotensinogen	Rattus norvegicus	136-150
6834388-5	1983	Two other proline derivatives containing a salicylate leaving group, (4S)-1-butyryl-4-[(carboxymethyl)methylamino]-L-proline, 2-ester with salicyclic acid (14a), and its 1-benzoyl analogue (14b), were designed to bind covalently to beta Lys-132, as well as to interact with beta His-2 and beta Thr-4 via ionic and hydrogen bonds.	Proline	10-17	histatin 3	Homo sapiens	279-284
6296095-5	1983	This indicates that oxygenation of the acid at C-5 occurred before the elimination of hydrogen and suggests that removal of the pro-S hydrogen at C-10 in 5-hydroperoxy-6,8,11,14,17-eicosapentaenoic acid initiates its transformation to trans-5(S),6(S)-oxido-7,9-trans-11,14,17-cis-eicosapentaenoic acid (leukotriene A5).	Proline	128-133	homeobox C10	Homo sapiens	146-150
6343842-1	1983	The activities of the proline-specific permease (PUT4) and the general amino acid permease (GAP1) of Saccharomyces cerevisiae vary 70- to 140-fold in response to the nitrogen source of the growth medium.	Proline	22-29	proline permease PUT4	Saccharomyces cerevisiae S288C	49-53
6343842-1	1983	The activities of the proline-specific permease (PUT4) and the general amino acid permease (GAP1) of Saccharomyces cerevisiae vary 70- to 140-fold in response to the nitrogen source of the growth medium.	Proline	22-29	amino acid permease GAP1	Saccharomyces cerevisiae S288C	92-96
6830820-2	1983	Clostridial aminopeptidase (EC 3.4.11-) cleaves off any N-terminal amino acid residue including proline from polypeptide chains, but does not cleave the N-terminal secondary peptide bonds involving a prolyl nitrogen.	Proline	96-103	carboxypeptidase Q	Homo sapiens	12-26
6339490-6	1983	The inhibitory effect of LACA could be prevented by L-proline; concomitant addition of L-proline (80 microgram/ml) with LACA (80 microgram/ml) resulted in complete restoration of milk protein synthesis to normal levels.	Proline	52-61	casein alpha s2-like A	Mus musculus	179-191
6339490-6	1983	The inhibitory effect of LACA could be prevented by L-proline; concomitant addition of L-proline (80 microgram/ml) with LACA (80 microgram/ml) resulted in complete restoration of milk protein synthesis to normal levels.	Proline	87-96	casein alpha s2-like A	Mus musculus	179-191
6860783-1	1983	It is shown that thrombin (0.1-7 units/ml) stimulates calcium mobilization and bone matrix degradation, as indicated by release of [3H]proline, from cultured calvarial bones.	Proline	135-142	coagulation factor II, thrombin	Homo sapiens	17-25
6826718-1	1983	In a previous study, molecular cloning of the alpha-globin genes from a patient with nondeletion Hb-H disease (genotype--/alpha alpha) showed that a single nucleotide mutation (CTG to CCG) in one of the genes resulted in a leucine to proline substitution.	Proline	234-241	hemoglobin subunit alpha 2	Homo sapiens	46-58
6838888-4	1983	The best substrates for thrombin were identified as those with arginine in the P1 position, proline or a proline homolog in the P2 position, and an apolar amino acid in the P3 position.	Proline	92-99	coagulation factor II, thrombin	Bos taurus	24-32
6838888-4	1983	The best substrates for thrombin were identified as those with arginine in the P1 position, proline or a proline homolog in the P2 position, and an apolar amino acid in the P3 position.	Proline	105-112	coagulation factor II, thrombin	Bos taurus	24-32
6363852-2	1983	Degradation of these peptides consisting of the amino acid sequence TYR-PRO-PHE-PRO-GLY-PRO-ILE and C-terminally shortened fragments thereof, may be due to an enzyme identical with or similar to the dipeptidyl-peptidase IV (DP IV) which is known to cleave dipeptide fragments from the N-terminus of peptides after proline residues.	Proline	314-321	dipeptidylpeptidase 4	Rattus norvegicus	199-222
6639644-8	1983	The possible influence of two exchanges in the alpha 1 beta 2 contact region (alpha 38 (C3) Thr leads to Ser and alpha 44 (CD2) Pro leads to Ser) on the oxygen affinity is discussed.	Proline	128-131	T-cell surface antigen CD2	Tursiops truncatus	123-126
6356166-5	1983	Proline and glycine residues suggest largely similar conformations between N-terminal parts of sorbitol dehydrogenase and "long" alcohol dehydrogenases, cysteine and histidine residues suggest a conserved zinc atom at the active site, and other residues correlate with structures of special importance.	Proline	0-7	sorbitol dehydrogenase	Homo sapiens	95-117
6838812-1	1983	Using the method of isomer-specific proteolysis, the isomerization of proline-93 has been monitored directly during the time course of the unfolding and refolding reactions of RNase A.	Proline	70-77	ribonuclease A family member 1, pancreatic	Homo sapiens	176-183
6188072-4	1983	The C-terminal hexa- and octapeptides of neurotensin (Arg-Arg-Pro-Tyr-Ile-Leu and Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu, respectively) induced a non-cytolytic release of histamine with the latter peptide being more active (ED50 = 90 microM for the hexapeptide and 13 microM for the octapeptide).	Proline	62-65	neurotensin	Homo sapiens	41-52
6297165-3	1983	We have established by nucleotide sequence analysis that both mutants carry exactly the same mutation in the DBP gene resulting in the substitution of a proline residue at position 413 in the wild-type DBP amino acid sequence (529 amino acid residues long) by a serine residue.	Proline	153-160	D-box binding PAR bZIP transcription factor	Homo sapiens	109-112
6297165-3	1983	We have established by nucleotide sequence analysis that both mutants carry exactly the same mutation in the DBP gene resulting in the substitution of a proline residue at position 413 in the wild-type DBP amino acid sequence (529 amino acid residues long) by a serine residue.	Proline	153-160	D-box binding PAR bZIP transcription factor	Homo sapiens	202-205
6357563-6	1983	The minimal substrate for renin is an octapeptide segment of the protein substrate: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Proline	88-91	renin	Homo sapiens	26-31
6848456-5	1983	Both NIF polypeptides contain one cysteine and one methionine, lack isoleucine, tyrosine and phenylalanine, and are rich in histidine and proline.	Proline	138-145	S100 calcium binding protein A9	Homo sapiens	5-8
6924862-4	1982	The kallikrein has an unusual amino acid composition: aspartic acid and glutamic acid comprise 40% of the residues; the total number of basic residues is less than 5%; glycine and proline together make up more than 40% of the residues.	Proline	180-187	kallikrein related peptidase 4	Homo sapiens	4-14
6363852-2	1983	Degradation of these peptides consisting of the amino acid sequence TYR-PRO-PHE-PRO-GLY-PRO-ILE and C-terminally shortened fragments thereof, may be due to an enzyme identical with or similar to the dipeptidyl-peptidase IV (DP IV) which is known to cleave dipeptide fragments from the N-terminus of peptides after proline residues.	Proline	314-321	dipeptidylpeptidase 4	Rattus norvegicus	224-229
7173213-0	1982	Proline isomerization in unfolded ribonuclease A.	Proline	0-7	ribonuclease A family member 1, pancreatic	Homo sapiens	34-48
6749882-2	1982	We have synthesized the 12 amino acid C-peptide region of IGF-I (Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Glu-Thr) and developed a RIA based on antibodies against this synthetic peptide.	Proline	101-104	insulin like growth factor 1	Homo sapiens	58-63
6751982-9	1982	The autodigestion of alpha-acrosin to beta-acrosin probably results in the liberation of the C-terminal portion of the molecule of the alpha-form; this portion is composed of roughly 85 residues and is rich in proline.	Proline	210-217	acrosin	Homo sapiens	27-34
7153783-1	1982	The incorporation of proline by cultured skin fibroblasts derived from normal individuals and patients with Duchenne muscular dystrophy (DMD) was analyzed by SDS-gel electrophoresis combined with a double-labeling procedure [Pediatr.	Proline	21-28	dystrophin	Homo sapiens	137-140
7153783-3	1982	DMD fibroblasts showed increased proline incorporation into protein of approximately 130 000 daltons which could be degraded partially by collagenase.	Proline	33-40	dystrophin	Homo sapiens	0-3
7153783-4	1982	This difference was observed only at 7 days after seeding, and may be due to slight differences in growth rate as comparison of cells harvested at 2 and 7 days indicated that increased proline incorporation into high molecular weight protein was associated with day 7 cells, whether normal or DMD.	Proline	185-192	dystrophin	Homo sapiens	293-296
7153783-6	1982	Incorporation of [14C]proline and [3H]leucine into extracellular proteins was greater in DMD fibroblast cultures.	Proline	22-29	dystrophin	Homo sapiens	89-92
7107651-5	1982	Further studies by in vitro translation analysis using the reticulocyte lysate system and labeling with [3H]proline or [35S]methionine show definitive changes in patterns of protein synthesis and proline-rich protein mRNAs are highly elevated in treated animals.	Proline	108-115	proline rich protein 2-like 1	Rattus norvegicus	196-216
7139961-0	1982	Optimal conditions for prolidase assay by proline colorimetric determination: application to iminodipeptiduria.	Proline	42-49	peptidase D	Homo sapiens	23-32
7139961-1	1982	Prolidase assay was reinvestigated by determining proline, using Chinard"s method.	Proline	50-57	peptidase D	Homo sapiens	0-9
7130893-0	1982	A new bioassay for human growth hormone based on incorporation of labelled proline into skin.	Proline	75-82	growth hormone 1	Homo sapiens	25-39
7104383-8	1982	The change in elastin concentration was accompanied by high hydroxyproline/proline or hydroxylysine/lysine ratios which indicates that the proteins of the aneurysmatic aortic wall contained more collagen than the proteins of the control aortic wall.	Proline	67-74	elastin	Homo sapiens	14-21
6751322-2	1982	The mucin, which was eluted in the void volume, had an amino acid profile typical of a salivary mucus glycoprotein with high proportions of threonine, serine and proline (48.8% of total amino acids), and low proportions of aromatic and basic amino acids.	Proline	162-169	solute carrier family 13 member 2	Rattus norvegicus	4-9
6751982-9	1982	The autodigestion of alpha-acrosin to beta-acrosin probably results in the liberation of the C-terminal portion of the molecule of the alpha-form; this portion is composed of roughly 85 residues and is rich in proline.	Proline	210-217	acrosin	Homo sapiens	43-50
6126250-3	1982	The second enzyme is a prolyl endopeptidase (apparent molecular weight 70,000 daltons) with a specificity restricted to proline peptide bonds wherein the proline is preceded by an alpha adjacent amino acid possessing a blocked N-terminus.	Proline	120-127	prolyl endopeptidase	Rattus norvegicus	23-43
6126250-3	1982	The second enzyme is a prolyl endopeptidase (apparent molecular weight 70,000 daltons) with a specificity restricted to proline peptide bonds wherein the proline is preceded by an alpha adjacent amino acid possessing a blocked N-terminus.	Proline	154-161	prolyl endopeptidase	Rattus norvegicus	23-43
6124421-4	1982	This enzyme cleaves N-terminal arginyl residues unless the adjacent penultimate residue is proline as is the case for bradykinin.	Proline	91-98	kininogen 1	Homo sapiens	118-128
7048310-2	1982	Comparison of the suppressor and wild-type sequences indicates that the SUF2 gene product is a proline tRNA.	Proline	95-102	SUF2	Saccharomyces cerevisiae S288C	72-76
6285984-7	1982	83, 441-448), it was found that, in the absence of ascorbate, prolyl 4-hydroxylase (prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating), EC 1.14.11.2) catalyses the hydroxylation of peptidyl proline, stoicheiometrically coupled to the oxidative decarboxylation of 2-oxoglutarate, at a high initial rate.	Proline	217-224	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	129-143
7118423-2	1982	spectroscopy, we have investigated cis-trans isomerism for N-acetyl, N"-methylamide derivatives of syn- and anti-5-methylproline (syn: the methyl group and carboxamide are on the same side of the proline ring, anti: on opposite sides).	Proline	121-128	synemin	Homo sapiens	130-133
7118423-3	1982	For Ac-syn-5-MeProNHMe, we observe about 25% cis peptide bond isomers in most solvents as is common for oligopeptides of proline.	Proline	121-128	synemin	Homo sapiens	7-10
7044414-5	1982	The extension is proline rich, which may contribute to the anomalous structural properties of rat alpha-lactalbumin.	Proline	17-24	lactalbumin, alpha	Rattus norvegicus	98-115
7037403-2	1982	The amino acid sequence of carp insulin displays some unusual features: the B chain is longer at the N terminus by two residues as compared with mammalian insulins and there are substitutions of the charged residues, found in most insulins at positions B21 and B22, by proline and threonine respectively.	Proline	269-276	insulin	Bos taurus	32-39
7074053-4	1982	During the course of chymotrypsin studies, it was demonstrated that bovine neurophysin II behaves as a transient competitive inhibitor of chymotrypsin; for neurophysin-peptide complexes, Ki congruent to 8 x 10(-6) M. This inhibition is dependent on neurophysin conformation and is relieved by the anomalous preferential splitting by chymotrypsin of Arg-Arg and Phe-Pro bonds near the carboxyl terminus of neurophysin II.	Proline	365-368	arginine vasopressin	Bos taurus	75-89
7067697-5	1982	The preferred solution conformation which is most strongly stabilized in dimethylsulfoxide in the neutral ion species includes a distorted beta-turn II involving the N-terminal sequence of Pro2-Pro3-Gly4-Phe5 and most likely a C7-type bend in the C-terminal part Ser-Pro-Phe.	Proline	189-192	pyrroline-5-carboxylate reductase 1	Homo sapiens	194-198
6282265-1	1982	The mitochondrial cytochrome c-557 of Crithidia oncopelti contains two lysine residues and an N-terminal proline residue that are methylated in vivo by the methyl group of methionine.	Proline	105-112	cytochrome c, somatic	Equus caballus	18-30
7077751-5	1982	When compared with the PR8 NA sequence, WSN NA appeared to possess a similar structure, including the identical location of all cysteine and proline residues.	Proline	141-148	Waisman syndrome	Homo sapiens	40-43
6280175-6	1982	However, HTLV p24 shares the common NH(2)-terminal proline and COOH-terminal leucine of all mammalian type C viral p30s.	Proline	51-58	transmembrane p24 trafficking protein 2	Homo sapiens	14-17
6799149-3	1982	These results suggest that factors in addition to TRH concentrations are important in determining the unique concentration pattern of cyclo-(His--Pro) in the brain.	Proline	146-149	thyrotropin releasing hormone	Rattus norvegicus	50-53
7068434-0	1982	Hemoglobin Kawachi [alpha 44 (CE2) Pro leads to Arg]: a new hemoglobin variant of high oxygen affinity with amino acid substitution at alpha 1 beta 2 contact.	Proline	35-38	carboxylesterase 2	Homo sapiens	30-33
16662144-1	1982	In excised pro(1-1) mutant and corresponding normal type roots of Zea mays L. the uptake and interconversion of [(14)C]proline, [(14)C]glutamic acid, [(14)C]glutamine, and [(14)C]ornithine and their utilization for protein synthesis was measured with the intention of finding an explanation for the proline requirement of the mutant.	Proline	119-126	profilin-1	Zea mays	11-18
16662144-1	1982	In excised pro(1-1) mutant and corresponding normal type roots of Zea mays L. the uptake and interconversion of [(14)C]proline, [(14)C]glutamic acid, [(14)C]glutamine, and [(14)C]ornithine and their utilization for protein synthesis was measured with the intention of finding an explanation for the proline requirement of the mutant.	Proline	299-306	profilin-1	Zea mays	11-18
16662144-7	1982	Based on these findings, and on the fact that ornithine, arginine, glutamic acid and aspartic acid are elevated as free amino acids in mutant roots, it is suggested that in the pro(1-1) mutant proline catabolism prevails over proline synthesis.	Proline	193-200	profilin-1	Zea mays	177-184
16662144-7	1982	Based on these findings, and on the fact that ornithine, arginine, glutamic acid and aspartic acid are elevated as free amino acids in mutant roots, it is suggested that in the pro(1-1) mutant proline catabolism prevails over proline synthesis.	Proline	226-233	profilin-1	Zea mays	177-184
6274413-5	1981	These data indicate that kininase II can release C-terminal tripeptides of substrates having a proline residue in the penultimate position such as des-Arg9-bradykinin and its analogues, and that this enzyme is able not only to act as a dipeptidyl carboxypeptidase but also acts as a tripeptidyl carboxy-peptidase.	Proline	95-102	angiotensin I converting enzyme	Homo sapiens	25-36
6274413-5	1981	These data indicate that kininase II can release C-terminal tripeptides of substrates having a proline residue in the penultimate position such as des-Arg9-bradykinin and its analogues, and that this enzyme is able not only to act as a dipeptidyl carboxypeptidase but also acts as a tripeptidyl carboxy-peptidase.	Proline	95-102	kininogen 1	Homo sapiens	156-166
6172555-4	1981	Amino acid analysis of P19 disclosed a high content of arginine (12.9%), leucine (11.9%), serine (10.3%) and proline (10.2%).	Proline	109-116	interleukin 23 subunit alpha	Homo sapiens	23-26
6976185-8	1981	The best substrate for thrombin was Z-Gly-Arg-SCH2C6H5, although substrates containing proline in the P2 position were also quite effective.	Proline	87-94	coagulation factor II, thrombin	Bos taurus	23-31
16662051-9	1981	On a percentage basis, the recovery of proline oxidation was greater than that of the other substrates.The decreases in the proline oxidase activity of mitochondria after only slight stress indicate a mitochondrial sensitivity to water stress at significantly less negative water potentials than previously reported for measurements of maize membrane permeability and respiratory activity.	Proline	39-46	proline oxidase	Zea mays	124-139
7311969-2	1981	In the present report we demonstrate that the proline analog, cis-4-hydroxy-L-proline, will inhibit myotube formation in vitro without affecting the aggregation of cells (fusion?).	Proline	46-53	suppressor of cytokine signaling 6	Homo sapiens	62-67
7318188-0	1981	Autoradiographic comparison of growth factors: influence of growth hormone and somatomedin B on patterns of proline incorporation.	Proline	108-115	growth hormone 1	Homo sapiens	60-74
7318188-0	1981	Autoradiographic comparison of growth factors: influence of growth hormone and somatomedin B on patterns of proline incorporation.	Proline	108-115	vitronectin	Homo sapiens	79-92
6273865-0	1981	The cyc1-11 mutation in yeast reverts by recombination with a nonallelic gene: composite genes determining the iso-cytochromes c. DNA sequence analysis of a cloned fragment directly established that the cyc1-11 mutation of iso-1-cytochrome c in the yeast Saccharomyces cerevisiae is a two-base-pair substitution that changes the CCA proline codon at amino acid position 76 to a UAA nonsense codon.	Proline	333-340	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	4-11
7026531-3	1981	Strains carrying the put4 mutation are defective in the high-affinity proline transport system.	Proline	70-77	proline permease PUT4	Saccharomyces cerevisiae S288C	21-25
7026531-6	1981	Low-affinity transport was inhibited by histidine, so put4 mutants were unable to grow on a medium containing high concentrations of proline to which histidine has been added.	Proline	133-140	proline permease PUT4	Saccharomyces cerevisiae S288C	54-58
6273865-0	1981	The cyc1-11 mutation in yeast reverts by recombination with a nonallelic gene: composite genes determining the iso-cytochromes c. DNA sequence analysis of a cloned fragment directly established that the cyc1-11 mutation of iso-1-cytochrome c in the yeast Saccharomyces cerevisiae is a two-base-pair substitution that changes the CCA proline codon at amino acid position 76 to a UAA nonsense codon.	Proline	333-340	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	4-8
6273865-0	1981	The cyc1-11 mutation in yeast reverts by recombination with a nonallelic gene: composite genes determining the iso-cytochromes c. DNA sequence analysis of a cloned fragment directly established that the cyc1-11 mutation of iso-1-cytochrome c in the yeast Saccharomyces cerevisiae is a two-base-pair substitution that changes the CCA proline codon at amino acid position 76 to a UAA nonsense codon.	Proline	333-340	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	223-228
19469937-3	1981	The first collagen used was tagged by the introduction of C1* into the peptide chain from marked proline by biosynthesis.	Proline	97-104	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	58-61
6947279-2	1981	Production of fibronectin by human alveolar macrophages obtained by bronchoalveolar lavage and maintained in short-term culture in serum-free conditions was demonstrated; de novo synthesis was confirmed by the incorporation of [14C]proline.	Proline	232-239	fibronectin 1	Homo sapiens	14-25
6167628-2	1981	The EAE-inducing determinant (synthetic peptide S6) H-Ala-Gln-Gly-His-Arg-Pro-Gln-Asp-Glu-Asn-OH (residues 75 to 84) of the bovine MBP induced clinical and histologic signs of EAE when it was administered at doses of 0.5 micrograms or higher.	Proline	74-77	myelin basic protein	Bos taurus	131-134
6115302-2	1981	Using a radioisotopic assay, we have studied the regulation by ornithine of delta 1-pyrroline-5-carboxylate synthase, the enzyme that catalyzes the first step of proline biosynthesis from glutamic acid.	Proline	162-169	aldehyde dehydrogenase 18 family member A1	Homo sapiens	76-116
6264603-3	1981	The location of glycine next to the carboxyl terminal prolinamide of calcitonin is consistent with indications that glycine is required for the enzymatic amidation of proline to the prolinamide.	Proline	167-174	calcitonin related polypeptide alpha	Homo sapiens	69-79
7021592-7	1981	The amino acid sequence of 25 nmol of the peptide was Asp-Arg-Val-Try-Ile-His-Pro-Phe, the same covalent structure as that of angiotensin II.	Proline	78-81	angiotensinogen	Homo sapiens	126-140
7019446-1	1981	Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).	Proline	269-272	gonadotropin releasing hormone 1	Rattus norvegicus	27-64
6787052-7	1981	Mucin A (pronase digest fraction 1 from molecular sieve chromatography) was enriched in threonine, proline, and sialic acid, while mucin B (pronase digest fraction 3 from molecular sieve chromatography) was enriched in serine, alanine, and fucose.	Proline	99-106	LOC100508689	Homo sapiens	0-5
7019446-1	1981	Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).	Proline	269-272	gonadotropin releasing hormone 1	Rattus norvegicus	66-71
6262650-0	1981	Circulating human pituitary pro-gamma-melanotropin enhances the adrenal response to ACTH.	Proline	28-31	proopiomelanocortin	Homo sapiens	84-88
16661754-5	1981	Glutamate dehydrogenase was confirmed as a matrix enzyme.Both proline and Delta(1)-pyrroline-5-carboxylic acid supported oxygen uptake in isolated mitochondria.	Proline	62-69	glutamic dehydrogenase1	Zea mays	0-23
7309353-3	1981	With free amino acids, the osmium(VIII) reagents are most reactive with Met, Cys, His, Thr, Ser, Trp, Lys, and Pro; the osmium(VI) reagent only reacts significantly with His, Met, Cys, Thr, and Ser.	Proline	111-114	cytochrome c oxidase subunit 8A	Homo sapiens	34-38
7209542-1	1981	The affinity of the amino terminal tetrapeptide of the beta chain of fibrin, Gly-His-Arg-Pro, for fibrinogen dramatically increases in the presence of 2 millimolar calcium ion.	Proline	89-92	fibrinogen beta chain	Homo sapiens	98-108
7009582-2	1981	The enzyme responsible for the final step in proline biosynthesis, pyrroline-5-carboxylate reductase, converts pyrroline-5-carboxylate to proline and is located in the cytoplasm.	Proline	45-52	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	67-100
7007378-8	1981	Automated Edman degradation of liver AGP which had been extracted from the immunoprecipitate with dilute acid and subsequently treated with pyroglutamate aminopeptidase yielded a sequence of proline and isoleucine identical with that in serum AGP.	Proline	191-198	orosomucoid 1	Rattus norvegicus	37-40
7009582-2	1981	The enzyme responsible for the final step in proline biosynthesis, pyrroline-5-carboxylate reductase, converts pyrroline-5-carboxylate to proline and is located in the cytoplasm.	Proline	138-145	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	67-100
7194346-2	1981	Two proline-independent revertants were isolated--K1-J and K1-6.	Proline	4-11	keratin 16	Homo sapiens	59-63
7194346-6	1981	CHO-K1 and K1-6 transport proline at the same initial rate and are equally sensitive to the inhibition of proline transport by alanine.	Proline	26-33	keratin 16	Homo sapiens	0-15
7194346-6	1981	CHO-K1 and K1-6 transport proline at the same initial rate and are equally sensitive to the inhibition of proline transport by alanine.	Proline	106-113	keratin 16	Homo sapiens	0-15
6256415-6	1981	The release of previously incorporated [3H]proline from the bones exposed to MCF-7 cell cultures was more closely associated with release of collagenolytic activity by MCF-7 cells than with release of cathepsin D or N-acetylglucosaminidase.	Proline	43-50	cathepsin D	Homo sapiens	201-212
7228489-0	1981	Conformation characterization of cyclopentapeptide, L.Val-L.Pro-Gly-L.Val-Gly: a repeating analogue of elastin.	Proline	60-63	elastin	Homo sapiens	103-110
6257480-1	1981	The structural requirements for the inhibition of net bone collagen synthesis by parathyroid hormone (PTH) in vitro have been examined by study of the effects of selected fragments and analogs of bovine PTH (bPTH) upon the incorporation of [3H]proline into collagenase-digestible and -nondigestible proteins by neonatal mouse calvarial bone in organ culture.	Proline	244-251	parathyroid hormone	Bos taurus	81-100
6895205-6	1981	The enzymes involved in degradation of proline are proline oxidase and P5C dehydrogenase; both are present in liver cells.	Proline	39-46	proline dehydrogenase	Mus musculus	51-66
6895205-6	1981	The enzymes involved in degradation of proline are proline oxidase and P5C dehydrogenase; both are present in liver cells.	Proline	39-46	aldehyde dehydrogenase 4 family, member A1	Mus musculus	71-88
6170909-0	1981	Substance P biosynthesis in dorsal root ganglia: an immunochemical study of [35S]methionine and [3H]proline incorporation in vitro.	Proline	100-107	tachykinin precursor 1	Homo sapiens	0-11
6159435-9	1980	We administered the proline analogue DHP at a dose that completely inhibited the elevated levels of lung prolyl hydroxylase activity.	Proline	20-27	dihydropyrimidinase	Rattus norvegicus	37-40
7213661-0	1980	Hemoglobin Milledgeville (alpha 44 (CD2) Pro leads to Leu): a new variant with increased oxygen affinity.	Proline	41-44	CD2 molecule	Homo sapiens	36-39
7213661-7	1980	The alpha CD2 proline residue normally participates in the formation of the alpha 1 beta 2 subunit interface in the deoxy quaternary conformation, but not in oxyhemoglobin; the leucine substitution may produce destabilization of the deoxy conformation with a resulting shift in equilibrium toward the oxy conformation.	Proline	14-21	CD2 molecule	Homo sapiens	10-13
6258629-1	1980	In the folding reaction of the slow-folding species (US) of ribonuclease A (RNase A), the slow isomerization of wrong proline isomers provides a suitable trap for kinetic folding intermediates at low temperatures (0--10 degrees C).	Proline	118-125	ribonuclease A family member 1, pancreatic	Homo sapiens	60-74
6258629-1	1980	In the folding reaction of the slow-folding species (US) of ribonuclease A (RNase A), the slow isomerization of wrong proline isomers provides a suitable trap for kinetic folding intermediates at low temperatures (0--10 degrees C).	Proline	118-125	ribonuclease A family member 1, pancreatic	Homo sapiens	76-83
6252249-9	1980	Cortisol decreased the stimulatory effect of IGF I on DNA labeling but greatly enhanced the stimulatory effect of IGF I on the incorporation of [3H]proline into CDP.	Proline	148-155	insulin-like growth factor 1	Rattus norvegicus	114-119
6252249-2	1980	IGF I caused a dose-dependent stimulation of the incorporation of [3H]thymidine into DNA at concentrations of 0.1--100 nM; the effect appeared after 6 h, was maximal at 12 h, and was sustained for 96 h. IGF I also increased the bone DNA content, IGF I at 0.1--3 nM had a small stimulatory effect on the incorporation of [3H]proline into collagenase-digestible protein (CDP) whereas 30 nM IGF I caused a two- to threefold increment and had a maximal effect.	Proline	324-331	insulin-like growth factor 1	Rattus norvegicus	0-5
6968225-3	1980	Epidermal growth factor caused a dose-dependent stimulation of protein synthesis (proline incorporation).	Proline	82-89	epidermal growth factor	Homo sapiens	0-23
7430266-3	1980	L-Proline, 2-aminoisobutyric acid, and glycine were primarily taken up by system A; L-alanine and L-serine by system ASC; L-phenylalanine by system L; and L-lysine by system Ly+ in SV3T3 cells.	Proline	0-9	steroid sulfatase	Mus musculus	117-120
7430266-4	1980	L-Proline and L-serine were also preferential substrates of systems A and ASC, respectively, in 3T3 and SV3T3 revertant cells.	Proline	0-9	steroid sulfatase	Mus musculus	74-77
6934501-1	1980	Parathyroid hormone decreased the incorporation of [3H]proline into collagenase-digestible protein in cultured 21-day fetal rat calvaria but had little effect on the labeling of noncollagen protein.	Proline	55-62	parathyroid hormone	Rattus norvegicus	0-19
7460499-0	1980	[Proline-iminopeptidase of the blood (PIP): and interesting alternative to urinary hydroxyproline].	Proline	1-8	prolactin induced protein	Homo sapiens	38-41
6252249-9	1980	Cortisol decreased the stimulatory effect of IGF I on DNA labeling but greatly enhanced the stimulatory effect of IGF I on the incorporation of [3H]proline into CDP.	Proline	148-155	cut-like homeobox 1	Rattus norvegicus	161-164
6108995-4	1980	Hydrolysis start from the N-terminal end, as shown by the appearance of proline as the first metabolite of the MIF degradation, followed by leucine, glycinamide, leucylglycine, and glycine.	Proline	72-79	macrophage migration inhibitory factor	Rattus norvegicus	111-114
6932503-2	1980	Recently, we have found that a proline-rich and basic glycoprotein (MGP) from human parotid saliva, which is successfully purified by Concanavalin A-Sepharose affinity chromatography, binds to some oral streptococci such as S. mitis and S. sanguis.	Proline	31-38	matrix Gla protein	Homo sapiens	68-71
6933565-4	1980	Peptide mapping analysis revealed that the structural abnormality of PGK-Uppsala is a single amino acid substitution from arginine to proline at the 206th position.	Proline	134-141	phosphoglycerate kinase 1	Equus caballus	69-72
17249054-13	1980	One of these mutants and another mutant isolated by E. H. Coe are proline-requiring mutants, allelic to pro-1.	Proline	66-73	profilin-1	Zea mays	104-109
6252249-2	1980	IGF I caused a dose-dependent stimulation of the incorporation of [3H]thymidine into DNA at concentrations of 0.1--100 nM; the effect appeared after 6 h, was maximal at 12 h, and was sustained for 96 h. IGF I also increased the bone DNA content, IGF I at 0.1--3 nM had a small stimulatory effect on the incorporation of [3H]proline into collagenase-digestible protein (CDP) whereas 30 nM IGF I caused a two- to threefold increment and had a maximal effect.	Proline	324-331	insulin-like growth factor 1	Rattus norvegicus	203-208
6252249-2	1980	IGF I caused a dose-dependent stimulation of the incorporation of [3H]thymidine into DNA at concentrations of 0.1--100 nM; the effect appeared after 6 h, was maximal at 12 h, and was sustained for 96 h. IGF I also increased the bone DNA content, IGF I at 0.1--3 nM had a small stimulatory effect on the incorporation of [3H]proline into collagenase-digestible protein (CDP) whereas 30 nM IGF I caused a two- to threefold increment and had a maximal effect.	Proline	324-331	insulin-like growth factor 1	Rattus norvegicus	203-208
6252249-2	1980	IGF I caused a dose-dependent stimulation of the incorporation of [3H]thymidine into DNA at concentrations of 0.1--100 nM; the effect appeared after 6 h, was maximal at 12 h, and was sustained for 96 h. IGF I also increased the bone DNA content, IGF I at 0.1--3 nM had a small stimulatory effect on the incorporation of [3H]proline into collagenase-digestible protein (CDP) whereas 30 nM IGF I caused a two- to threefold increment and had a maximal effect.	Proline	324-331	insulin-like growth factor 1	Rattus norvegicus	203-208
6111031-2	1980	Nearly all of this activity can be accounted for by the action of two enzymes, both of which cleave Pro and Leu sequentially from the N-terminus of MIF.	Proline	100-103	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	148-151
6248543-5	1980	These findings are consistent with the proposal that cis-trans isomerism of peptide bonds that are NH2-terminal to proline residues is responsible for the slow phase of RNase A refolding.	Proline	115-122	ribonuclease A family member 1, pancreatic	Homo sapiens	169-176
6248543-7	1980	Instead, the data reveal that, although the native structure of RNase A contains two cis prolines, cis isomers need not be present in the fast-refolding form in order for folding to occur.	Proline	89-97	ribonuclease A family member 1, pancreatic	Homo sapiens	64-71
6997175-2	1980	As expected, the infusion of insulin exhibited significant reduction of the release of glycine, proline, valine, phenylalanine, leucine, threonine and isoleucine.	Proline	96-103	insulin	Homo sapiens	29-36
6776531-7	1980	The NH2-terminal sequence of CNBr II revealed the active site serine of factor D. The typical serine protease active site sequence (Gly-Asp-Ser-Gly-Gly-Pro  was found at residues 12-17.	Proline	152-155	coagulation factor II, thrombin	Homo sapiens	94-109
6778962-5	1980	Peptides with proline at the NH2 end activated prolidase, whereas those with proline at the carboxyl end inhibited it.	Proline	14-21	peptidase D	Bos taurus	47-56
6155176-0	1980	Cleavage of substance P to an N-terminal tetrapeptide and a C-terminal heptapeptide by a post-proline Cleaving enzyme from bovine brain.	Proline	94-101	tachykinin precursor 1	Bos taurus	12-23
6107906-0	1980	Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.	Proline	27-31	somatostatin	Sus scrofa	56-68
6928678-0	1980	Evidence for involvement of proline cis-trans isomerization in the slow unfolding reaction of RNase A.	Proline	28-35	ribonuclease A family member 1, pancreatic	Homo sapiens	94-101
6772230-3	1980	It was similar to the chicken riboflavin-binding protein in its behavior on ion-exchange celluloses and affinity to interact with the flavin and its coenzymes, but differed significantly in amino acid composition in that it completely lacked proline and contained less of methionine and arginine.	Proline	242-249	riboflavin binding protein	Gallus gallus	30-56
7372583-3	1980	Some of the carbons of the proline residues of glycoprotein 6 are also identified.	Proline	27-34	glycoprotein VI platelet	Homo sapiens	47-61
7390979-0	1980	The amino acid sequence of a salivary proline-rich peptide, P-C, and its relation to a salivary proline-rich phosphoprotein, protein C.	Proline	38-45	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	125-134
6892988-0	1980	Linkage of the HMP pathway to ATP generation by the proline cycle.	Proline	52-59	inner membrane mitochondrial protein	Homo sapiens	15-18
7228251-3	1980	The yields of NPYR formed from pyrrolidine, putrescine, agmatine, spermidine, spermine, proline, ornithine and arginine with nitrite in the pH range 6.6 to 4.0 were determined.	Proline	88-95	neuropeptide Y receptor Y1	Homo sapiens	14-18
7228251-8	1980	The formation of NPYR and NPIP from proline, pyrrolidine, putrescine, spermidine and cadaverine was studied in a model experiment, using minced bacon as the reaction medium.	Proline	36-43	neuropeptide Y receptor Y1	Homo sapiens	17-21
390239-6	1979	When the supportive hormones, insulin, prolactin, hydrocortisone, progesterone, and estradiol are removed from the cultures, there is a 90 per cent reduction in the amount of  [3H]proline recovered in collagen synthesis coincides with only a 30 percentdrop in the growht rate and a 20 per cent drop in total protein synthesis of the sells over the 24-hour period without hormones.	Proline	180-187	prolactin	Rattus norvegicus	39-48
6928653-1	1980	[1-Sarcosine,8-isoleucine]angiotensin II (Sar-Arg-Val-Tyr-Ile-His-Pro-Ile) has been shown to be a potent antagonist of the pressor action of angiotensin II.	Proline	66-69	angiotensinogen	Homo sapiens	26-40
6928653-1	1980	[1-Sarcosine,8-isoleucine]angiotensin II (Sar-Arg-Val-Tyr-Ile-His-Pro-Ile) has been shown to be a potent antagonist of the pressor action of angiotensin II.	Proline	66-69	angiotensinogen	Homo sapiens	141-155
7375500-5	1980	These observations demonstrate the existence of functional differences for the proline residue in angiotensin II and angiotensin III analogs and may reflect differences in conformation and modes of binding to smooth muscle receptors between the two classes of peptides.	Proline	79-86	angiotensinogen	Rattus norvegicus	98-112
115864-6	1979	10(-4) M) is inhibited competitively by TRF analogues which contain proline or by the proline containing biologically active peptides luliberin (LH-RF), oxytocin, vasopressin, angiotensin II, and Substance P.	Proline	68-75	interleukin 5	Bos taurus	40-43
115864-6	1979	10(-4) M) is inhibited competitively by TRF analogues which contain proline or by the proline containing biologically active peptides luliberin (LH-RF), oxytocin, vasopressin, angiotensin II, and Substance P.	Proline	68-75	tachykinin precursor 1	Bos taurus	196-207
115864-6	1979	10(-4) M) is inhibited competitively by TRF analogues which contain proline or by the proline containing biologically active peptides luliberin (LH-RF), oxytocin, vasopressin, angiotensin II, and Substance P.	Proline	86-93	tachykinin precursor 1	Bos taurus	196-207
115864-7	1979	TRF analogues without proline or peptide amides without proline are ineffective.	Proline	22-29	interleukin 5	Bos taurus	0-3
115864-7	1979	TRF analogues without proline or peptide amides without proline are ineffective.	Proline	56-63	interleukin 5	Bos taurus	0-3
476124-4	1979	This substrate showed a higher affinity (Km = 0.02 mM) for the enzyme than the proline containing substrates studied previously and allowed the detection of 10-50 ng post-proline cleaving enzyme activity per ml sample after a 1 min incubation period.	Proline	79-86	prolyl endopeptidase	Homo sapiens	166-194
488004-2	1979	Protein synthesis was quantitated by measuring the incorporation of [3H]proline into collagenase-digestible (CDP) and noncollagen protein (NCP) using bacterial collagenase; [3H]proline was added for the last 2 h of culture.	Proline	72-79	cut-like homeobox 1	Rattus norvegicus	109-112
574261-9	1979	Diisopropylphosphorofluoridate--a specific inhibitor of dipeptidyl peptidase IV--decreases the reabsorption of L-proline and L-alanine but has no influence on the reabsorption of the basic amino acid L-arginine and the acidic amino acid L-glutamic acid.	Proline	111-120	dipeptidylpeptidase 4	Rattus norvegicus	56-79
574261-10	1979	This result correlates with a recent speculation that dipeptidyl peptidase IV is involved in proline and alanine reabosrption.	Proline	93-100	dipeptidylpeptidase 4	Rattus norvegicus	54-77
582801-1	1979	Biosynthetic conversion of tyrosine to the C2- and C3-proline moieties of anthramycin, tomaymycin, and sibiromycin.	Proline	54-61	complement C2	Homo sapiens	43-53
387738-2	1979	Strains carrying the mutation, put3, are partially constitutive for proline oxidase and delta 1-pyrroline-5-carboxylate dehydrogenase when grown on a medium lacking proline and are hyperinducible for both enzyme activities when grown on a proline-containing medium.	Proline	68-75	Put3p	Saccharomyces cerevisiae S288C	31-35
387738-2	1979	Strains carrying the mutation, put3, are partially constitutive for proline oxidase and delta 1-pyrroline-5-carboxylate dehydrogenase when grown on a medium lacking proline and are hyperinducible for both enzyme activities when grown on a proline-containing medium.	Proline	165-172	Put3p	Saccharomyces cerevisiae S288C	31-35
387738-3	1979	put3 segregates as a single nuclear gene, is not linked to either of the presumed structural genes for proline oxidase and delta 1-pyrroline-5-carboxylate dehydrogenase, and does not affect proline transport.	Proline	103-110	Put3p	Saccharomyces cerevisiae S288C	0-4
387738-5	1979	Endogenous induction by proline has been eliminated as a cause of the inducer-independent enzyme expression in the put3 mutant and the mutation is believed to be in a regulatory component of the proline-degradative pathway.	Proline	24-31	Put3p	Saccharomyces cerevisiae S288C	115-119
387738-5	1979	Endogenous induction by proline has been eliminated as a cause of the inducer-independent enzyme expression in the put3 mutant and the mutation is believed to be in a regulatory component of the proline-degradative pathway.	Proline	195-202	Put3p	Saccharomyces cerevisiae S288C	115-119
114209-13	1979	Residue 45 in the Dob sequence is proline, although all other known heavy-chain sequences in man, mouse, rabbit, and guinea pig have leucine at this position.	Proline	34-41	major histocompatibility complex, class II, DO beta	Homo sapiens	18-21
447743-1	1979	Radioisotopic experiments have revealed that free trans-4-hydroxy-L-proline is an intermediate synthesized from L-proline during formation of the peptide-bound cis-4-hydroxy-D-proline residue in the antibiotic, etamycin.	Proline	66-75	suppressor of cytokine signaling 6	Homo sapiens	160-165
378940-4	1979	Mutants defective in the pro1 and pro2 genes can be satisfied by arginine or ornithine as well as proline.	Proline	98-105	glutamate 5-kinase	Saccharomyces cerevisiae S288C	25-29
447726-1	1979	The reaction of tryptamine with indolyl-3-alkane alpha-hydroxylase is shown to remove stereospecifically the pro-S hydrogen at C-2 of the side chain and to give hydroxytryptamine of "R" configuration.	Proline	109-114	complement C2	Homo sapiens	127-130
447726-3	1979	In the reaction of L-tryptophan methyl ester, the enzyme also catalyzes stereospecific removal of the pro-S hydrogen at C-3, but the product 3-hydroxytryptophan methyl ester is racemic at C-3.	Proline	102-107	complement C3	Homo sapiens	120-123
447726-3	1979	In the reaction of L-tryptophan methyl ester, the enzyme also catalyzes stereospecific removal of the pro-S hydrogen at C-3, but the product 3-hydroxytryptophan methyl ester is racemic at C-3.	Proline	102-107	complement C3	Homo sapiens	188-191
487287-4	1979	The results show that the proline residue in position 7 of [Sar1,Ile8]-angiotensin II may be replaced by other secondary amino acids without disrupting interactions at angiotensin II receptors.	Proline	26-33	angiotensinogen	Rattus norvegicus	71-85
376847-2	1979	In new and surprising relationships, it was found that the substitution of D-Trp into position 3 of [D- less than Glu1,D-Phe2,amino acid3,D-Phe6]-LH-RH significantly enhanced the antiovulatory potency, but substitution by Pro, N-Me-Phe,N-Me-Leu, or L-Trp reduced antiovulatory activity.	Proline	222-225	gonadotropin releasing hormone 1	Rattus norvegicus	146-151
385449-4	1979	The 12 cyc1 alleles include one ochre, one amber, four initiation, two proline missense, and four frameshift mutations.	Proline	71-78	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	7-11
378940-6	1979	A pro3 mutant has been shown by enzyme assay to be deficient in delta 1-pyrroline-5-carboxylate reductase which converts pyrroline-5-carboxylate to proline.	Proline	148-155	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	2-6
438294-1	1979	Ornithine aminotransferase catalyzes the reversible transamination of L-ornithine to delta1-pyrroline-5-carboxylate, the immediate precursor of proline.	Proline	144-151	ornithine aminotransferase	Homo sapiens	0-26
107159-2	1979	An extract of porcine brain acetone powder incubated with thyrotropin-releasing hormone (TRH; pGlu-His-ProNH2) produces acid TRH (pGlu-His-Pro), histidine, and prolineamide.	Proline	103-106	thyrotropin releasing hormone	Homo sapiens	58-87
107159-2	1979	An extract of porcine brain acetone powder incubated with thyrotropin-releasing hormone (TRH; pGlu-His-ProNH2) produces acid TRH (pGlu-His-Pro), histidine, and prolineamide.	Proline	103-106	thyrotropin releasing hormone	Homo sapiens	89-92
107159-2	1979	An extract of porcine brain acetone powder incubated with thyrotropin-releasing hormone (TRH; pGlu-His-ProNH2) produces acid TRH (pGlu-His-Pro), histidine, and prolineamide.	Proline	103-106	thyrotropin releasing hormone	Homo sapiens	125-128
762075-3	1979	The NH2-terminal residue of CRP is pyrrolidonecarboxylic acid and the COOH terminus is proline.	Proline	87-94	C-reactive protein	Homo sapiens	28-31
30754-6	1978	Measurement of amino acid uptake show that the mutants with high glutamine synthetase levels have increased rates for glutamine, arginine, aspartate, and lysine, but a decreased rate for proline.	Proline	187-194	type I glutamate--ammonia ligase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	65-85
43840-6	1979	In aqueous ethanol the X-Asc-Y-NH2 (X, Pro, Leu; Y, Gly, Ala, Val, Phg, Phe) containing N-terminal proline are more readily transformed to piperazine-2,5-dione derivatives, but compared to simple proline dipeptides the rate of this transformation is relatively slow because of the crowdedness of the tricyclic transitional state.	Proline	39-42	PYD and CARD domain containing	Homo sapiens	25-28
43840-6	1979	In aqueous ethanol the X-Asc-Y-NH2 (X, Pro, Leu; Y, Gly, Ala, Val, Phg, Phe) containing N-terminal proline are more readily transformed to piperazine-2,5-dione derivatives, but compared to simple proline dipeptides the rate of this transformation is relatively slow because of the crowdedness of the tricyclic transitional state.	Proline	99-106	PYD and CARD domain containing	Homo sapiens	25-28
43840-6	1979	In aqueous ethanol the X-Asc-Y-NH2 (X, Pro, Leu; Y, Gly, Ala, Val, Phg, Phe) containing N-terminal proline are more readily transformed to piperazine-2,5-dione derivatives, but compared to simple proline dipeptides the rate of this transformation is relatively slow because of the crowdedness of the tricyclic transitional state.	Proline	196-203	PYD and CARD domain containing	Homo sapiens	25-28
107022-3	1978	The increase in rate of formation of proline, a major plasma degradation product, was in very good agreement with the increase in rate of TRH degradation.	Proline	37-44	thyrotropin releasing hormone	Rattus norvegicus	138-141
102466-2	1978	In this assay, the formation of proline, a major serum degradation product of TRH (pGlu-His-Pro-NH2), is measured.	Proline	32-39	thyrotropin releasing hormone	Homo sapiens	78-81
687639-3	1978	In contrast, the N-terminal Arg-Pro of bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) was not cleaved by the enzyme.	Proline	32-35	kininogen 1	Homo sapiens	39-49
893419-2	1977	TnC was found to be a single polypeptide chain of 159 amino acid residues, including 2 residues of tyrosine and 1 each of cysteine, histidine, and proline.	Proline	147-154	tenascin	Oryctolagus cuniculus	0-3
96140-3	1978	Concomitantly, in cord and maternal sera, the rate of formation of proline, a major TRH degradation product in serum, was one-quarter to one-third that in euthyroid adult sera.	Proline	67-74	thyrotropin releasing hormone	Homo sapiens	84-87
26912-4	1978	On the other hand, proline uptake is demonstrated to be inhibited progressively at pH 5.5, 6.6, and 7.5 in colicin Ia-treated cells.	Proline	19-26	colicin	Escherichia coli	107-114
352341-0	1978	The proton exchange of the pro-S hydrogen atom at C-1 in dihydroxyacetone phosphate and D-fructose 1,6-bisphosphate catalysed by class-I and class-II aldolases.	Proline	27-32	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	50-53
415884-4	1977	Also, the responses to other GL-containing polymers, such as poly-L (Glu, Lys, Ala) and poly-L (Glu, Lys, Pro), which are under the control of distinct Ir genes, can stimulate the production of GL-binding antibodies that share common BGL idiotypic determinants with antibodies induced with GLphi.	Proline	106-109	galactosidase, beta 1	Mus musculus	234-237
22075-4	1977	The slower of the two phases seen for the parvalbumin is about 100 to 500 times faster than the slow phase seen for proline-containing proteins under the same conditions!	Proline	116-123	parvalbumin	Homo sapiens	42-53
558989-2	1977	Among the cell lines tested, only LLC-RK1 cells, derived from rabbit kidney, had significant Proline Oxidase activity; the Km for proline of the enzyme from these cells was similar to that for the liver enzyme.	Proline	130-137	proline dehydrogenase	Mus musculus	93-108
19034-1	1977	The properties of aqueous solutions of synthetic renin substrate tetradecapeptide (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser) were examined through electrometric titrations, infrared and circular dichroism spectroscopy, and spectrofluorometry.	Proline	107-110	renin	Homo sapiens	49-54
19034-2	1977	Titration studies of angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) were also made, whose results indicated a flexible folded conformation similar to that previously proposed for the octapeptide angiotensin II, with a possible additional beta turn at the C terminus.	Proline	60-63	angiotensinogen	Homo sapiens	21-34
558989-3	1977	LLC cells, Proline Oxidase positive, were able to convert proline to CO2.	Proline	58-65	proline dehydrogenase	Mus musculus	11-26
862347-11	1977	This correlation was not observed with unhydrolysed urine, and it appeared to reside in the diffusible fraction, part of whose proline could be liberated by prolidase digestion.	Proline	127-134	peptidase D	Homo sapiens	157-166
869925-3	1977	The content of glycine, proline and dicarboxylicamino acids accounts for 83% of the total resideus of protein C and it contains 2.0 mol of P/mol of protein, most likely as phosphoserine.	Proline	24-31	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	102-111
849474-3	1977	The protein spectrum contains unusually intense resonances due to glutamic acid and proline and has been simulated satisfactorily using the known amino acid composition of chromogranin A.	Proline	84-91	chromogranin A	Bos taurus	172-186
871045-3	1977	Mathematical computer-assisted programs developed to aid in determining clusters of amino acid variables suggested that excretion of glycine, leucine, proline, and glutamic acid in men and concentrations of valine, serine, aspartic acid, phenylalanine, and lysine in women vary according to the invasiveness of the disease.	Proline	151-158	activation induced cytidine deaminase	Homo sapiens	53-56
870607-6	1977	Proline incorporation into collagenase-digestible protein was similar in cultures of normal and mutant bone and was inhibited by PTH and OAF.	Proline	0-7	parathyroid hormone	Mus musculus	129-132
870607-6	1977	Proline incorporation into collagenase-digestible protein was similar in cultures of normal and mutant bone and was inhibited by PTH and OAF.	Proline	0-7	out at first homolog	Mus musculus	137-140
849256-0	1977	Salivary peroxidase (SAPX): genetic modification and relationship to the proline-rich (Pr) and acidic (Pa) proteins.	Proline	73-80	lactoperoxidase	Homo sapiens	0-19
13825-5	1977	The results obtained indicate that substitutions in aspartic acid 1, proline 7, and phenylalanine 8 of angiotensin II entail changes in the backbone conformation.	Proline	69-76	angiotensinogen	Homo sapiens	103-117
849256-0	1977	Salivary peroxidase (SAPX): genetic modification and relationship to the proline-rich (Pr) and acidic (Pa) proteins.	Proline	73-80	lactoperoxidase	Homo sapiens	21-25
847371-3	1977	The proline loading correctly identified the normality of GH axis in 12 out of 22 controls and in 3 out of 7 normopituitary short-statured patients.	Proline	4-11	growth hormone 1	Homo sapiens	58-60
592823-2	1977	The carboxyl-terminal sequence of rhodopsin is Val-Ser-Lys-Thr-Glu-Thr-Ser-Gln-Val-Ala-Pro-Ala.	Proline	87-90	rhodopsin	Bos taurus	34-43
847371-0	1977	L-proline loading for the assessment of pituitary GH reserve.	Proline	0-9	growth hormone 1	Homo sapiens	50-52
12509-2	1976	The uptake system for proline was Na+ gradient dependent, and exhibited a dual system for entry, Km1 = 0.067 mM and Km2 = 5.26 mM.	Proline	22-29	Kidney mass QTL 1	Rattus norvegicus	97-100
1009126-4	1976	Several analogs of the octapeptide segment: His-Pro-Phe-His-Leu-Leu-Val-Tyr of this tetradecapeptide act as competitive inhibitors for human renin with inhibition constants down to 1 muM.	Proline	48-51	renin	Homo sapiens	141-146
12509-2	1976	The uptake system for proline was Na+ gradient dependent, and exhibited a dual system for entry, Km1 = 0.067 mM and Km2 = 5.26 mM.	Proline	22-29	Kidney mass QTL 2	Rattus norvegicus	116-119
820546-10	1976	Using [14C]proline as the label, it appeared that rather large amounts of radioactively labeled deamido-TRH, which was identified as such by vigorous purification, could be isolated from such incubates.	Proline	11-18	thyrotropin releasing hormone	Homo sapiens	104-107
965296-5	1976	Collagen and elastin which amounted to 10.45 and 4.62 mg, respectively, per 100 mg dry defatted parenchymal tissue was labeled with [14C]proline injected ip.	Proline	137-144	elastin	Cavia porcellus	13-20
791096-0	1976	Specific action of 4-nitropyridine 1-oxide on Excherichia coli K-12 pro+ strains leading to the isolation of proline-requiring mutants: isolation and characterization of pro-mutants.	Proline	109-116	keratin 12	Homo sapiens	63-67
1008857-3	1976	Insulin enhanced the transport rate of substrate amino acids from the A system(alpha-aminoisobutyric acid, L-proline, glycine, L-alanine and L-serine) in fibroblasts and osteoblasts from chick-embryo tissues, in mesenchymal cells (fibroblasts and smooth muscle cells) from immature rat uterus, in thymic lymphocytes from young rats and in chick-embryo fibroblasts from confluent secondary cultures.	Proline	107-116	insulin	Gallus gallus	0-7
820546-5	1976	In hypothalamic and cortical tissue preparations, on incubation with TRH labeled with [3H]proline, fast formation of radioactively labeled deamido-TRH and liberation of prolineamide and free proline were found.	Proline	90-97	thyrotropin releasing hormone	Homo sapiens	69-72
820546-8	1976	The peptidolytic cleavage of TRH by brain enzymes, yielding proline and prolineamide as split products, was also effectively reduced using comparatively high concentrations of the dipeptide ester without, however, preventing TRH deamidation.	Proline	60-67	thyrotropin releasing hormone	Homo sapiens	29-32
2300-0	1976	Partial purification and characterization of post-proline cleaving enzyme: enzymatic inactivation of neurohypophyseal hormones by kidney preparations of various species.	Proline	50-57	arginine vasopressin	Homo sapiens	101-117
945152-2	1976	1) PTH decreased the incorporation of labeled proline into CDP at concentrations similar to those which stimulate bone resorption in vitro.	Proline	46-53	parathyroid hormone	Rattus norvegicus	3-6
945152-2	1976	1) PTH decreased the incorporation of labeled proline into CDP at concentrations similar to those which stimulate bone resorption in vitro.	Proline	46-53	cut-like homeobox 1	Rattus norvegicus	59-62
945152-7	1976	In 3 hour experiments, PTH did increase the labeling of CDP and NCP, but only at tracer concentration of proline in the medium, compatible with an early stimulation of amino acid uptake.	Proline	105-112	parathyroid hormone	Bos taurus	23-26
3198-2	1976	N-acetyl-L-phenylalaninamide, support our previous conclusion (Biochemistry 12, 3780, 1973) that the positive 221-nm CD band of bradykinin is a composite of bands due to two chromophores, the 217-nm band characteristic of the Phe residues overlying the 223-nm band of the N-terminal sequence, Arg-Pro-Pro.	Proline	297-300	kininogen 1	Homo sapiens	128-138
3198-2	1976	N-acetyl-L-phenylalaninamide, support our previous conclusion (Biochemistry 12, 3780, 1973) that the positive 221-nm CD band of bradykinin is a composite of bands due to two chromophores, the 217-nm band characteristic of the Phe residues overlying the 223-nm band of the N-terminal sequence, Arg-Pro-Pro.	Proline	301-304	kininogen 1	Homo sapiens	128-138
932208-1	1976	Lymphokine-rich supernates from normal human peripheral blood mononuclear cells, stimulated by the mitogen phytohemagglutinin, have been shown to cause enhanced collagen accumulation by human embryonic lung fibroblasts (WI-38), as measured by hydroxyproline content of fibroblast monolayers, [14C] proline incorporation into soluble collagen and collagenase release of radioactivity in supernates and monolayers of cultures incubated with [14C] proline.	Proline	250-257	interleukin 2	Homo sapiens	0-10
932208-1	1976	Lymphokine-rich supernates from normal human peripheral blood mononuclear cells, stimulated by the mitogen phytohemagglutinin, have been shown to cause enhanced collagen accumulation by human embryonic lung fibroblasts (WI-38), as measured by hydroxyproline content of fibroblast monolayers, [14C] proline incorporation into soluble collagen and collagenase release of radioactivity in supernates and monolayers of cultures incubated with [14C] proline.	Proline	298-305	interleukin 2	Homo sapiens	0-10
934727-5	1976	When hydroxyproline was infused with an increased concentration of proline in the hyperprolinemic patient, hydroxyproline uptake first increased (9.8--14.3 muM/min/20 cm) then decreased to its basal value, whereas, in the control subjects, uptake increased without decreasing subsequently.	Proline	12-19	latexin	Homo sapiens	156-159
2300-10	1976	In vivo experiments in the cat suggested that both the glycinamide-releasing enzyme and post-proline cleaving enzyme are present and effective in inactivating neurohypophyseal hormones in the intact animal.	Proline	93-100	arginine vasopressin	Homo sapiens	159-175
134872-3	1976	Soluble elastin is identified as a [14C] hydroxyproline-labelled peak of molecular weight approximately 70,000 daltons which also incorporates large quantities of [3H] valine and has a [14C] hydroxyproline/[14C] proline ratio of about 0.2.	Proline	48-55	elastin	Gallus gallus	8-15
1091634-1	1975	Treatment of Escherichia coli with colicin Ia leads to an inhibition in the active transport of exogenously supplied proline, thiomethyl-beta-D-galactoside and potassium ion.	Proline	117-124	colicin Ia	Escherichia coli	35-45
1198105-1	1975	Fibroblasts freshly isolated from embryonic tendons were incubated with a proline analog, cis-4-hydroxy-L-proline, which is incorporated into protein and which leads to the intracellular accumulation of nonhelical procollagen.	Proline	74-81	suppressor of cytokine signaling 6	Homo sapiens	90-95
1133566-1	1975	After two daily ovine prolactin injections in rats, significant increases in jejunal absorption of glucose, glycine and proline, as well as of fluid and NaCl, occurred.	Proline	120-127	prolactin	Rattus norvegicus	22-31
810892-2	1975	The susceptible Pro-Thr bond lies in a unique region of the IgA heavy chain; the IgA2 subclass, lacking this peptide bond, is enzyme resistant.	Proline	16-19	CD79a molecule	Homo sapiens	60-63
821746-4	1975	Of the TRH analogues tested, only two (Ser-His-Pro-NH2, Thr-His-Pro-NH2) had potent reactivity to anti-TRH serum in large dose of 100 ng/tube.	Proline	47-50	thyrotropin releasing hormone	Homo sapiens	103-106
821746-4	1975	Of the TRH analogues tested, only two (Ser-His-Pro-NH2, Thr-His-Pro-NH2) had potent reactivity to anti-TRH serum in large dose of 100 ng/tube.	Proline	64-67	thyrotropin releasing hormone	Homo sapiens	103-106
241397-0	1975	Isolation and functional characterization of hemoglobin Casper: beta106(G8) Leu replaced by Pro.	Proline	92-95	small nucleolar RNA host gene 32	Homo sapiens	45-74
765256-3	1975	The amino acid composition of [alpha1 (III)]3 purified by CM-cellulose chromatography and agarose-gel chromatography includes two cysteine residues per chain, and the hydroxyproline/proline ratio is greater than 1.0.	Proline	174-181	adrenoceptor alpha 1D	Homo sapiens	30-45
169122-5	1975	In cultures treated with cycloheximide (10 mug/ml) or proline (6.3 mM) the initial binding of [2,3-3H-Pro]TRH to receptors, measured after 1 h, was 97% or 102% of control.	Proline	54-61	thyrotropin releasing hormone	Rattus norvegicus	106-109
169122-6	1975	However, the incorporation of label from [2,3-3H-Pro]TRH into an acid-precipitable product after 22 h was inhibited by 81 and 74% by cycloheximide (1 mug/ml) and proline (2.5 mM).	Proline	162-169	thyrotropin releasing hormone	Rattus norvegicus	53-56
169122-7	1975	Formation of [2,3-3H] proline from [2,3-?3H-Pro] TRH was demonstrated by thin layer chromatography; the percentage of non-protein radioactivity with an Rf of proline increased from 20 to 80% in GH3 cells incubated 1 or 24 h with [2,3-3H-Pro]TRH.	Proline	22-29	thyrotropin releasing hormone	Rattus norvegicus	49-52
169122-7	1975	Formation of [2,3-3H] proline from [2,3-?3H-Pro] TRH was demonstrated by thin layer chromatography; the percentage of non-protein radioactivity with an Rf of proline increased from 20 to 80% in GH3 cells incubated 1 or 24 h with [2,3-3H-Pro]TRH.	Proline	22-29	thyrotropin releasing hormone	Rattus norvegicus	241-244
169122-8	1975	We conclude that after binding to receptors on GH3 cells, TRH is slowly metabolized to its constituent amino acids, and the products [2,3-3H]proline or [14C]histidine are incorporated into newly synthesized proteins.	Proline	141-148	thyrotropin releasing hormone	Rattus norvegicus	58-61
1141204-15	1975	Intracellular concentrations of seven amino acids, including threonine, serine, proline, glycine, alanine, lysine, and arginine, were increased significantly in livers perfused with medium containing growth hormone...	Proline	80-87	gonadotropin releasing hormone receptor	Rattus norvegicus	200-214
4447620-9	1974	Increased hydroxylation of proline in the embryo was, however, readily observed in peptide alpha(1)-CB2 from the helical region of tendon collagen.	Proline	27-34	cannabinoid receptor 2	Rattus norvegicus	100-103
4268097-7	1973	The oxidative pathway was sensitive to cyanide and uncouplers and, in contrast with proline, required an active ATPase.	Proline	84-91	ATPase	Escherichia coli	112-118
4352462-0	1973	Hemoglobin Abraham Lincoln, beta32 (B14) leucine leads to proline.	Proline	58-65	NADH:ubiquinone oxidoreductase subunit A6	Homo sapiens	36-39
4995924-4	1971	With the use of synthetic thyrotropin-releasing hormone, detected by the Pauly reagent or with (125)1-labeled thyrotropin-releasing hormone as a marker, thin-layer chromatograms, paper electrophoresis, and carboxymethyl cellulose ion exchange chromatography revealed that only proline, histidine, and glutamic acid were consistently incorporated into peptides associated with the thyrotropin-releasing hormone region.	Proline	277-284	thyrotropin releasing hormone	Rattus norvegicus	26-55
11452384-2	1971	The C-terminal ends of bovine fibrinogen and fibrin were identified as proline and valine, in the molar ratio of approximately 1:2.	Proline	71-78	fibrinogen beta chain	Homo sapiens	30-40
11452384-9	1971	It should be noted that hydrophobic amino acids, like isoleucine, valine and proline, are mainly located in the C-terminal ends of all three chain peptides in the fibrinogen molecule.	Proline	77-84	fibrinogen beta chain	Homo sapiens	163-173
5087830-0	1971	Growth hormone inhibition of proline hydroxylation in vitro.	Proline	29-36	growth hormone 1	Homo sapiens	0-14
5528745-1	1970	Conformation of peptides with intact and overlapping helices obtained by cleavage of myoglobin at proline peptide bonds.	Proline	98-105	myoglobin	Homo sapiens	85-94
5280529-3	1971	The resulting oxytocin structure places the bulky side chains of the leucine and isoleucine residues, as well as the cyclic moiety of the proline residue, at corners of the two beta-turns.	Proline	138-145	oxytocin/neurophysin I prepropeptide	Homo sapiens	14-22
5123875-2	1971	Isolated chick embryo heart cells were used to investigate the mode of action of insulin on the transport of three naturally occurring amino acids: l-proline, l-serine and glycine.	Proline	148-157	insulin	Gallus gallus	81-88
5135422-0	1971	[Effect of the administration of human growth hormone on L-proline tolerance in pituitary dwarfism].	Proline	57-66	growth hormone 1	Homo sapiens	39-53
5440287-0	1970	A human serum aminopeptidase capable of splitting juxtaterminal bonds involving proline.	Proline	80-87	carboxypeptidase Q	Homo sapiens	14-28
5500318-9	1970	The results suggested that the effect of ascorbic acid deficiency on elastin biosynthesis could be regarded as simply an elimination of hydroxylation of elastin proline with the formation and retention of a polymer increasingly deficient in hydroxyproline.	Proline	161-168	elastin	Cavia porcellus	69-76
5500318-9	1970	The results suggested that the effect of ascorbic acid deficiency on elastin biosynthesis could be regarded as simply an elimination of hydroxylation of elastin proline with the formation and retention of a polymer increasingly deficient in hydroxyproline.	Proline	161-168	elastin	Cavia porcellus	153-160
4309121-15	1969	Studies with chick embryos confirmed the formation of elastin hydroxyproline from free proline.	Proline	69-76	elastin	Gallus gallus	54-61
4309121-11	1969	The proline/hydroxyproline specific-radioactivity ratio in elastin from scorbutic guinea pigs was about 6:1 in contrast with the 1:1 ratio in control groups.	Proline	4-11	elastin	Cavia porcellus	59-66
5822045-0	1969	Substrate specificity of collagen proline hydroxylase: hydroxylation of a specific proline residue in bradykinin.	Proline	34-41	kininogen 1	Homo sapiens	102-112
4309308-8	1969	Insulin increased the uptake by isolated heart cells of several (14)C-labelled naturally occurring amino acids; however, the fraction of amino acid taken up by the cells that was recovered free intracellularly, and therefore the concentration ratio (between intracellular water and medium), was enhanced by the hormone only with glycine, proline, serine, threonine, histidine and methionine.	Proline	338-345	insulin	Gallus gallus	0-7
5699463-0	1968	[Cleavage of proline bonds by carboxypeptidase C].	Proline	13-20	cathepsin A	Homo sapiens	30-48
24519792-7	1968	In the presence of kinetin, proline considerably stimulated the increase in peroxidase activity.Discussed are the way in which hypro may be acting, and the possibility of peroxidase being involved in proline hydroxylation.	Proline	200-207	peroxidase N1	Nicotiana tabacum	171-181
4387724-0	1968	Kinetic study on the oxidation of L-proline by D-amino-acid oxidase.	Proline	34-43	D-amino acid oxidase	Homo sapiens	47-67
5662012-10	1968	It is suggested that the compounds his(6)-pro(7)-phe(8)-his(9)-leu(10)-leu(11)-val(12)-tyr(13)-ser(14) or his(6)-pro(7)-phe(8)-his(9)-leu(10)-leu(11)-val(12)-tyr(13) might be used as substrates for the chemical assay and standardization of renin.	Proline	42-45	renin	Homo sapiens	240-245
33844328-8	2021	This new strategy shows slight improvements over an alternative side chain perturbation strategy for a set T4 lysozyme mutations lacking proline and glycine, and yields good agreement with experiment for a set of T4 lysozyme proline and glycine mutations not previously studied.	Proline	225-232	lysozyme	Homo sapiens	216-224
24519792-7	1968	In the presence of kinetin, proline considerably stimulated the increase in peroxidase activity.Discussed are the way in which hypro may be acting, and the possibility of peroxidase being involved in proline hydroxylation.	Proline	28-35	peroxidase N1	Nicotiana tabacum	76-86
24519792-7	1968	In the presence of kinetin, proline considerably stimulated the increase in peroxidase activity.Discussed are the way in which hypro may be acting, and the possibility of peroxidase being involved in proline hydroxylation.	Proline	28-35	peroxidase N1	Nicotiana tabacum	171-181
24519792-7	1968	In the presence of kinetin, proline considerably stimulated the increase in peroxidase activity.Discussed are the way in which hypro may be acting, and the possibility of peroxidase being involved in proline hydroxylation.	Proline	200-207	peroxidase N1	Nicotiana tabacum	76-86
6061694-0	1967	Hydroxylation of proline in synthetic polypeptides with purified protocollagen hydroxylase.	Proline	17-24	prolyl 4-hydroxylase subunit beta	Homo sapiens	65-90
5620075-0	1967	[Biological investigation of growth hormone effects on radioactive proline incorporation into procollagen of the rat skin].	Proline	67-74	gonadotropin releasing hormone receptor	Rattus norvegicus	29-43
14325957-0	1965	STUDIES ON L-PROLINE:NAD(P)+2-OXIDOREDUCTASE OF HOG KIDNEY.	Proline	11-20	thioredoxin reductase 1	Homo sapiens	30-44
13704552-2	1960	Turnover of collagen labeled with proline-U-C14 in young rats.	Proline	34-41	anti-Mullerian hormone receptor type 2	Rattus norvegicus	44-47
33844328-8	2021	This new strategy shows slight improvements over an alternative side chain perturbation strategy for a set T4 lysozyme mutations lacking proline and glycine, and yields good agreement with experiment for a set of T4 lysozyme proline and glycine mutations not previously studied.	Proline	137-144	lysozyme	Homo sapiens	110-118
13883962-0	1962	A mutant form of ornithine transcarbamylase found in a strain of Neurospora carrying a pyrimidine-proline suppressor gene.	Proline	98-105	ornithine transcarbamylase	Homo sapiens	17-43
33878557-4	2021	Characterisation of the peptides in treated beer showed that prolyl-endopeptidase activity was not complete with many peptides containing (multiple) internal proline-residues.	Proline	158-165	prolyl endopeptidase	Homo sapiens	61-81
33862453-4	2021	We found that the interfering with the folding of secondary structure with proline, a potent breaker of secondary structure, completely abolished the migration and metastasis-inhibitory activity of EC1 mimic peptide.	Proline	75-82	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	198-201
33862453-6	2021	Next, we substitute with proline for amino acid residues in the small extracellular ring region of CD82/KAI1 by the site-specific mutations to disrupting secondary structure and detected its effect on the function of CD82/KAI1.	Proline	25-32	CD82 molecule	Homo sapiens	99-103
33862453-6	2021	Next, we substitute with proline for amino acid residues in the small extracellular ring region of CD82/KAI1 by the site-specific mutations to disrupting secondary structure and detected its effect on the function of CD82/KAI1.	Proline	25-32	CD82 molecule	Homo sapiens	104-108
33862453-6	2021	Next, we substitute with proline for amino acid residues in the small extracellular ring region of CD82/KAI1 by the site-specific mutations to disrupting secondary structure and detected its effect on the function of CD82/KAI1.	Proline	25-32	CD82 molecule	Homo sapiens	217-221
33862453-6	2021	Next, we substitute with proline for amino acid residues in the small extracellular ring region of CD82/KAI1 by the site-specific mutations to disrupting secondary structure and detected its effect on the function of CD82/KAI1.	Proline	25-32	CD82 molecule	Homo sapiens	222-226
33651140-2	2021	YAP, as a Hippo pathway downstream effector, plays a key role in promoting tumor development through the interaction with transcription factor TEAD on the NH3-terminal proline-rich domain.	Proline	168-175	Yes1 associated transcriptional regulator	Homo sapiens	0-3
33675809-4	2021	RESULTS: The mutation is a single base substitution at codon 65 of the alpha1 globin gene [alpha65(E14) Ala>Pro; HBA1: c.196G>C] and leads to the substitution of a proline residue in the E helix.	Proline	108-111	hemoglobin subunit alpha 1	Homo sapiens	113-117
33675809-4	2021	RESULTS: The mutation is a single base substitution at codon 65 of the alpha1 globin gene [alpha65(E14) Ala>Pro; HBA1: c.196G>C] and leads to the substitution of a proline residue in the E helix.	Proline	164-171	hemoglobin subunit alpha 1	Homo sapiens	113-117
33675809-7	2021	CONCLUSIONS: The substitution alpha65(E14) Ala>Pro; HBA1: c.196G>C causes a alpha-thalassemia silent associated with a very mild phenotype.	Proline	47-50	hemoglobin subunit alpha 1	Homo sapiens	52-56
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Proline	82-85	reticulon 4	Rattus norvegicus	93-99
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Proline	82-85	Eph receptor A4	Rattus norvegicus	112-117
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Proline	82-85	reticulon 4	Rattus norvegicus	182-188
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Proline	82-85	Eph receptor A4	Rattus norvegicus	197-202
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Proline	145-148	reticulon 4	Rattus norvegicus	93-99
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Proline	145-148	Eph receptor A4	Rattus norvegicus	112-117
34052659-4	2021	We identified proline- and glutamine-rich (SFPQ) as a protein associating with tyrosine-phosphorylated HELZ2.	Proline	14-21	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	Mus musculus	43-47
33888598-5	2021	NADK2-mediated mitochondrial NADP(H) generation was required for the reduction of glutamate and hence proline biosynthesis.	Proline	102-109	NAD kinase 2, mitochondrial	Homo sapiens	0-5
33895677-5	2021	ABREs are present across the promoter of the P5CS1 gene, whose upregulation is considered a hallmark for drought inducible proline accumulation.	Proline	123-130	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	45-50
34048122-0	2021	Structural Basis for the Stereospecific Inhibition of the Dual Proline/Hydroxyproline Catabolic Enzyme ALDH4A1 by Trans-4-Hydroxy-L-Proline.	Proline	63-70	aldehyde dehydrogenase 4 family, member A1	Mus musculus	103-110
34048122-1	2021	Aldehyde dehydrogenase 4A1 (ALDH4A1) catalyzes the final steps of both proline and hydroxyproline catabolism.	Proline	71-78	aldehyde dehydrogenase 4 family, member A1	Mus musculus	0-26
34048122-1	2021	Aldehyde dehydrogenase 4A1 (ALDH4A1) catalyzes the final steps of both proline and hydroxyproline catabolism.	Proline	71-78	aldehyde dehydrogenase 4 family, member A1	Mus musculus	28-35
34048122-3	2021	Here we investigated the inhibition of mouse ALDH4A1 by the six stereoisomers of proline and 4-hydroxyproline using steady-state kinetics and X-ray crystallography.	Proline	81-88	aldehyde dehydrogenase 4 family, member A1	Mus musculus	45-52
34048122-10	2021	Also, drugs targeting the first enzyme of hydroxyproline catabolism, by elevating the level of trans-4-hydroxy-L-proline, may inadvertently impair proline catabolism by the inhibition of ALDH4A1.	Proline	49-56	aldehyde dehydrogenase 4 family, member A1	Mus musculus	187-194
34052659-4	2021	We identified proline- and glutamine-rich (SFPQ) as a protein associating with tyrosine-phosphorylated HELZ2.	Proline	14-21	helicase with zinc finger 2, transcriptional coactivator	Mus musculus	103-108
34019384-2	2021	Most members are constructed from a single-core beta-alpha-beta motif or two consecutively fused beta-alpha-beta motifs in which the N-terminal proline (Pro-1) plays a key and unusual role as a catalytic residue.	Proline	144-151	lamin A/C	Homo sapiens	153-158
34035379-8	2021	Additionally, the proline 3-hydroxylation sites in type I collagen were also over-hydroxylated in Rcn3 deficient mice.	Proline	18-25	reticulocalbin 3, EF-hand calcium binding domain	Mus musculus	98-102
34014654-1	2021	Human ornithine aminotransferase (hOAT) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that was recently found to play an important role in the metabolic reprogramming of hepatocellular carcinoma (HCC) via the proline and glutamine metabolic pathways.	Proline	214-221	ornithine aminotransferase	Homo sapiens	6-32
34003320-0	2021	Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target.	Proline	61-68	pyrroline-5-carboxylate reductase 1	Homo sapiens	89-122
34003320-0	2021	Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target.	Proline	61-68	pyrroline-5-carboxylate reductase 1	Homo sapiens	124-128
34003320-4	2021	Here we focus on the last enzyme of proline biosynthesis, Delta1-pyrroline-5-carboxylate reductase, known as PYCR in humans.	Proline	36-43	pyrroline-5-carboxylate reductase 1	Homo sapiens	109-113
34003320-5	2021	PYCR catalyzes the NAD(P)H-dependent reduction of Delta1-pyrroline-5-carboxylate to proline and forms the reductive half of the proline metabolic cycle.	Proline	84-91	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-4
34003320-5	2021	PYCR catalyzes the NAD(P)H-dependent reduction of Delta1-pyrroline-5-carboxylate to proline and forms the reductive half of the proline metabolic cycle.	Proline	128-135	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-4
33733565-2	2021	Herein, we report the collective asymmetric total synthesis of C-11 oxygenated Cephalotaxus alkaloids using a chiral proline both as a starting material and as the only chirality source.	Proline	117-124	RNA polymerase III subunit K	Homo sapiens	63-67
33998043-3	2022	The multiple roles of BAG3 are attributed to its functional regions like BAG, Tryptophan-rich (WW), isoleucine-proline-valine-rich (IPV), and proline-rich (PXXP) domains.	Proline	111-118	BAG cochaperone 3	Homo sapiens	22-26
33734376-1	2021	The final step in proline biosynthesis is catalyzed by three pyrroline-5-carboxylate reductases, PYCR1, PYCR2, and PYCR3, which convert pyrroline-5-carboxylate (P5C) to proline.	Proline	18-25	pyrroline-5-carboxylate reductase 1	Mus musculus	97-102
33734376-1	2021	The final step in proline biosynthesis is catalyzed by three pyrroline-5-carboxylate reductases, PYCR1, PYCR2, and PYCR3, which convert pyrroline-5-carboxylate (P5C) to proline.	Proline	18-25	pyrroline-5-carboxylate reductase family, member 2	Mus musculus	104-109
33734376-13	2021	Proline levels were not reduced, and precursors were not increased in serum from Pycr2 mutant mice or in lysates from skin fibroblast cultures, but placing Pycr2 mutant mice on a proline-free diet worsened the phenotype.	Proline	179-186	pyrroline-5-carboxylate reductase family, member 2	Mus musculus	156-161
33734376-14	2021	Thus, Pycr1 and -2 have redundant functions in proline biosynthesis, and their loss makes proline a semi-essential amino acid.	Proline	47-54	pyrroline-5-carboxylate reductase 1	Mus musculus	6-18
33734376-14	2021	Thus, Pycr1 and -2 have redundant functions in proline biosynthesis, and their loss makes proline a semi-essential amino acid.	Proline	90-97	pyrroline-5-carboxylate reductase 1	Mus musculus	6-18
33734376-1	2021	The final step in proline biosynthesis is catalyzed by three pyrroline-5-carboxylate reductases, PYCR1, PYCR2, and PYCR3, which convert pyrroline-5-carboxylate (P5C) to proline.	Proline	169-176	pyrroline-5-carboxylate reductase 1	Mus musculus	97-102
33998043-3	2022	The multiple roles of BAG3 are attributed to its functional regions like BAG, Tryptophan-rich (WW), isoleucine-proline-valine-rich (IPV), and proline-rich (PXXP) domains.	Proline	142-149	BAG cochaperone 3	Homo sapiens	22-26
33734376-1	2021	The final step in proline biosynthesis is catalyzed by three pyrroline-5-carboxylate reductases, PYCR1, PYCR2, and PYCR3, which convert pyrroline-5-carboxylate (P5C) to proline.	Proline	169-176	pyrroline-5-carboxylate reductase family, member 2	Mus musculus	104-109
33952698-11	2021	Our results unveil the role of proline polymorphisms (e.g., at P64) associated with many diseases and suggest that the function of glycosylated cell surface receptors is dynamically regulated by Gal-3.	Proline	31-38	galectin 3	Homo sapiens	195-200
33734376-11	2021	Both PYCR1 and -2 were able to complement loss of Pro3, the yeast enzyme that converts P5C to proline, confirming their activity as P5C reductases.	Proline	94-101	pyrroline-5-carboxylate reductase 1	Mus musculus	5-17
33734376-11	2021	Both PYCR1 and -2 were able to complement loss of Pro3, the yeast enzyme that converts P5C to proline, confirming their activity as P5C reductases.	Proline	94-101	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	50-54
33931484-8	2021	Two Itk-related features of SLP-76, Y173 and a proline-rich Itk SH3 binding motif on SLP-76, were dispensable for activation of NFAT but selectively required for the TCR/CD28-induced increase in cytoplasmic and nuclear c-Rel and consequent RE/AP activation.	Proline	47-54	IL2 inducible T cell kinase	Mus musculus	4-7
33931484-8	2021	Two Itk-related features of SLP-76, Y173 and a proline-rich Itk SH3 binding motif on SLP-76, were dispensable for activation of NFAT but selectively required for the TCR/CD28-induced increase in cytoplasmic and nuclear c-Rel and consequent RE/AP activation.	Proline	47-54	lymphocyte cytosolic protein 2	Homo sapiens	28-34
33931484-8	2021	Two Itk-related features of SLP-76, Y173 and a proline-rich Itk SH3 binding motif on SLP-76, were dispensable for activation of NFAT but selectively required for the TCR/CD28-induced increase in cytoplasmic and nuclear c-Rel and consequent RE/AP activation.	Proline	47-54	IL2 inducible T cell kinase	Mus musculus	60-63
33931484-8	2021	Two Itk-related features of SLP-76, Y173 and a proline-rich Itk SH3 binding motif on SLP-76, were dispensable for activation of NFAT but selectively required for the TCR/CD28-induced increase in cytoplasmic and nuclear c-Rel and consequent RE/AP activation.	Proline	47-54	lymphocyte cytosolic protein 2	Homo sapiens	85-91
33931484-8	2021	Two Itk-related features of SLP-76, Y173 and a proline-rich Itk SH3 binding motif on SLP-76, were dispensable for activation of NFAT but selectively required for the TCR/CD28-induced increase in cytoplasmic and nuclear c-Rel and consequent RE/AP activation.	Proline	47-54	T cell receptor alpha variable 6-3	Mus musculus	166-169
33861612-4	2021	In this work, 3-furoic acid (3-Fu) was successfully employed as an l-proline (Pro) surrogate, affording two potent MIF-1 analogues, methyl 3-furoyl-l-leucylglycinate (4a) and 3-furoyl-l-leucylglycinamide (6a).	Proline	67-76	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	115-120
33861612-4	2021	In this work, 3-furoic acid (3-Fu) was successfully employed as an l-proline (Pro) surrogate, affording two potent MIF-1 analogues, methyl 3-furoyl-l-leucylglycinate (4a) and 3-furoyl-l-leucylglycinamide (6a).	Proline	78-81	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	115-120
33975938-4	2021	Here, we show that this RBD conjugated to each of two carrier proteins elicited more potent neutralizing responses in immunized rodents than did a similarly conjugated proline-stabilized S-protein ectodomain.	Proline	168-175	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	187-188
33952698-1	2021	Galectin-3 (Gal-3) has a long, aperiodic, and dynamic proline-rich N-terminal tail (NT).	Proline	54-61	galectin 3	Homo sapiens	0-10
33952698-1	2021	Galectin-3 (Gal-3) has a long, aperiodic, and dynamic proline-rich N-terminal tail (NT).	Proline	54-61	galectin 3	Homo sapiens	12-17
33952698-4	2021	Our findings show that mutation of any single proline (especially P37A, P55A, P60A, P64A/H, and P67A) dramatically and differentially inhibits Gal-3-mediated cellular activities (i.e., cell migration, activation, endocytosis, and hemagglutination).	Proline	46-53	galectin 3	Homo sapiens	143-148
33952698-5	2021	For mechanistic insight, we investigated the role of prolines in mediating Gal-3 oligomerization, a fundamental process required for these cell activities.	Proline	53-61	galectin 3	Homo sapiens	75-80
33947761-3	2021	PspA and PspC both carry a proline-rich domain (PRD) whose role, other than serving as a flexible connector between the N-terminal and C-terminal domains, was up to this point unknown.	Proline	27-34	pneumococcal surface protein A	Streptococcus pneumoniae	0-4
33948880-10	2021	The absence of neurological complications in the first patient is justifiable due to the maintenance of the proline-rich region in DOCK8, but for the second patient with expanded deletion which is almost like null DOCK8 protein, it is not presumable, pointing to the fact that the C terminal region of the protein might have functions in the proliferation and migration neurons in the peripheral nervous system.	Proline	108-115	dedicator of cytokinesis 8	Homo sapiens	131-136
33787846-3	2021	For example, the combination of a linear proline-rich motif and hydrophobic core domain surface allows Nef to bind tightly and specifically to SH3 domains of Src family kinases.	Proline	41-48	S100 calcium binding protein B	Homo sapiens	103-106
33609296-5	2021	Rather than impacting methionine or cysteine, ACT with CTH overexpression unexpectedly reduced glycine, serine and proline concentration within the tumor interstitial fluid.	Proline	115-122	cystathionase (cystathionine gamma-lyase)	Mus musculus	55-58
33760200-10	2021	The incorporation of [3H]proline into RPE cells was also increased by CTGF.	Proline	25-32	cellular communication network factor 2	Homo sapiens	70-74
33675071-0	2021	Low expression of tRF-Pro-CGG predicts poor prognosis in pancreatic ductal adenocarcinoma.	Proline	22-25	telomeric repeat binding factor 1	Homo sapiens	18-21
33512474-6	2021	Signaling adaptor domains of CBL, including the tyrosine-kinase binding domain, proline-rich region, and C-terminal phosphotyrosine sites, were all required for the oncogenic function of CBL mutants.	Proline	80-87	Cbl proto-oncogene	Homo sapiens	29-32
33933448-5	2021	We performed a yeast two-hybrid screen using Dasm1, revealing MRCKbeta as a putative partner; additional lines of evidence confirmed this interaction and identified cytoplasmic proline-rich region (823-947 aa) of Dasm1 and MRCKbeta self-activated kinase domain (CC1, 410-744 aa) as necessary and sufficient for binding.	Proline	177-184	CDC42 binding protein kinase beta	Mus musculus	62-70
33933448-5	2021	We performed a yeast two-hybrid screen using Dasm1, revealing MRCKbeta as a putative partner; additional lines of evidence confirmed this interaction and identified cytoplasmic proline-rich region (823-947 aa) of Dasm1 and MRCKbeta self-activated kinase domain (CC1, 410-744 aa) as necessary and sufficient for binding.	Proline	177-184	immunoglobulin superfamily, member 9	Mus musculus	213-218
33932695-7	2021	Deeper mechanistic studies showed that costunolide triggered the prolyl hydroxylase 2 (PHD2)-triggered proline hydroxylation-ubiquitination-proteasome degradation of HIF-1alpha, which in turn inactivated glycolytic process in Th17 rather than Treg cells.	Proline	103-110	egl-9 family hypoxia-inducible factor 1	Mus musculus	65-85
33932695-7	2021	Deeper mechanistic studies showed that costunolide triggered the prolyl hydroxylase 2 (PHD2)-triggered proline hydroxylation-ubiquitination-proteasome degradation of HIF-1alpha, which in turn inactivated glycolytic process in Th17 rather than Treg cells.	Proline	103-110	egl-9 family hypoxia-inducible factor 1	Mus musculus	87-91
33932695-7	2021	Deeper mechanistic studies showed that costunolide triggered the prolyl hydroxylase 2 (PHD2)-triggered proline hydroxylation-ubiquitination-proteasome degradation of HIF-1alpha, which in turn inactivated glycolytic process in Th17 rather than Treg cells.	Proline	103-110	hypoxia inducible factor 1, alpha subunit	Mus musculus	166-176
33512474-6	2021	Signaling adaptor domains of CBL, including the tyrosine-kinase binding domain, proline-rich region, and C-terminal phosphotyrosine sites, were all required for the oncogenic function of CBL mutants.	Proline	80-87	Cbl proto-oncogene	Homo sapiens	187-190
33866786-4	2021	Herein, we developed a novel CL probe for the detection of endogenous FAPalpha activity by incorporating FAPalpha-specific dipeptide substrates (glycine-proline) to the improved Schaap"s adamantylidene-dioxetane.	Proline	153-160	fibroblast activation protein	Mus musculus	70-78
33866786-4	2021	Herein, we developed a novel CL probe for the detection of endogenous FAPalpha activity by incorporating FAPalpha-specific dipeptide substrates (glycine-proline) to the improved Schaap"s adamantylidene-dioxetane.	Proline	153-160	fibroblast activation protein	Mus musculus	105-113
33515561-2	2021	In this study, we identified a functional histone H2B mutation H2BL-T11C, causing an amino acid variation from Leu to Pro (L3P, H2BL-L3P).	Proline	118-121	H2B clustered histone 4	Homo sapiens	63-67
33888066-7	2021	Interestingly a reverse trend was observed in the case of the relative expression of the genes involved in the proline metabolism such as P5CS, P5CR, PDH, and P5CDH under the same conditions.	Proline	111-118	delta-pyrroline-5-carboxylate synthetase	Glycine max	138-142
33888066-7	2021	Interestingly a reverse trend was observed in the case of the relative expression of the genes involved in the proline metabolism such as P5CS, P5CR, PDH, and P5CDH under the same conditions.	Proline	111-118	pyrroline-5-carboxylate reductase	Glycine max	144-148
33888066-7	2021	Interestingly a reverse trend was observed in the case of the relative expression of the genes involved in the proline metabolism such as P5CS, P5CR, PDH, and P5CDH under the same conditions.	Proline	111-118	proline dehydrogenase	Glycine max	150-153
33922069-9	2021	Malondialdehyde (MDA) and proline contents were remarkably high in SlGRAS10-RNAi plants.	Proline	26-33	GRAS10 protein	Solanum lycopersicum	67-75
33923901-2	2021	After 24 h of cadmium (Cd) stress, the proline concentration remained low in A and B1 leaves, while in B2 and C leaves, it increased, and after 48 h, an increase in the proline concentration in the leaves at each stage of development was observed.	Proline	39-46	membrane spanning 4-domains A1	Homo sapiens	77-85
33923901-6	2021	When the time courses of abscisic acid (ABA) and proline accumulation were compared, it was concluded that an increase in the proline concentration in the leaves of Cd-treated pea plants was more related to a decrease in chlorophyll concentration (leaves B2 and C) and an increase in the malondialdehyde level (A and B1 leaves) than with an increase in ABA concentration alone.	Proline	126-133	membrane spanning 4-domains A1	Homo sapiens	311-319
33823140-5	2021	p53-regulated speckle association did not depend on p53 transactivation functions but required an intact proline-rich domain and direct DNA binding, providing mechanisms within p53 for regulating gene-speckle association.	Proline	105-112	tumor protein p53	Homo sapiens	0-3
33928085-11	2021	Finally, we demonstrated the direct interaction between DOX and TLR2 via hydrogen bonds on Pro-681 and Glu-727 and Pro-681 and Ser-704 may be the key residues by which LCZ696 affects the interaction between DOX and TLR2.	Proline	91-94	toll-like receptor 2	Rattus norvegicus	64-68
33928085-11	2021	Finally, we demonstrated the direct interaction between DOX and TLR2 via hydrogen bonds on Pro-681 and Glu-727 and Pro-681 and Ser-704 may be the key residues by which LCZ696 affects the interaction between DOX and TLR2.	Proline	115-118	toll-like receptor 2	Rattus norvegicus	64-68
33840009-6	2021	Molecular dynamics (MD) simulation analysis demonstrated that this proline hydroxylation in IgA1 caused both local and global structural changes.	Proline	67-74	immunoglobulin heavy constant alpha 1	Homo sapiens	92-96
33862083-6	2021	Here we showed that the equivalent proline is highly conserved in Rpt2, Rpt3, and Rpt5, and loosely conserved in Rpt1, in deeply divergent eukaryotes.	Proline	35-42	proteasome regulatory particle base subunit RPT2	Saccharomyces cerevisiae S288C	66-70
33862083-6	2021	Here we showed that the equivalent proline is highly conserved in Rpt2, Rpt3, and Rpt5, and loosely conserved in Rpt1, in deeply divergent eukaryotes.	Proline	35-42	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	72-76
33862083-6	2021	Here we showed that the equivalent proline is highly conserved in Rpt2, Rpt3, and Rpt5, and loosely conserved in Rpt1, in deeply divergent eukaryotes.	Proline	35-42	proteasome regulatory particle base subunit RPT5	Saccharomyces cerevisiae S288C	82-86
33862083-6	2021	Here we showed that the equivalent proline is highly conserved in Rpt2, Rpt3, and Rpt5, and loosely conserved in Rpt1, in deeply divergent eukaryotes.	Proline	35-42	proteasome regulatory particle base subunit RPT1	Saccharomyces cerevisiae S288C	113-117
33924512-7	2021	High levels of Ps-1, II-2 and IB-1 proteins belonging to basic proline rich proteins (bPRPs) and PRP-1 protein belonging to acid proline rich proteins (aPRPs) were found in OB males, who showed a lower body mass index (BMI) than OB females.	Proline	63-70	taste 2 receptor member 62 pseudogene	Homo sapiens	15-25
33924512-7	2021	High levels of Ps-1, II-2 and IB-1 proteins belonging to basic proline rich proteins (bPRPs) and PRP-1 protein belonging to acid proline rich proteins (aPRPs) were found in OB males, who showed a lower body mass index (BMI) than OB females.	Proline	63-70	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	30-34
33838225-8	2021	Three non-proline cis-peptides were detected in the sugar-binding cleft of BRP39, including Ser57-Phe58, Leu141-Tyr142, and Trp353-Ala354.	Proline	10-17	chitinase-like 1	Mus musculus	75-80
33918024-6	2021	The antioxidant system was effective in removing reactive oxygen species (ROS) that could damage photosynthesis; a significant positive and negative linear correlation was observed between the rate of CO2 uptake and ascorbic acid (AsA)/total AsA (AsAt) and proline, respectively.	Proline	257-264	ATP binding cassette subfamily B member 7	Homo sapiens	247-251
33829379-9	2021	Proline treatment at 100 mg L-1 increased leaf fresh weight (FW) and dry weight (DW); chl a, b, and proline content; SOD activity under both non-stress and stress conditions; Y (II) under salinity and carotenoid content; and CAT activity under control conditions.	Proline	0-7	catalase	Homo sapiens	225-228
33460563-7	2021	Recombinant human CCL1 promoted ESCC cell motility via the Akt/proline-rich Akt substrate of 40 kDa (PRAS40)/mammalian target of rapamycin (mTOR) pathway.	Proline	63-70	C-C motif chemokine ligand 1	Homo sapiens	18-22
33917227-4	2021	Lck binds to a receptor kinase (RK) motif and Nck binds to a proline-rich sequence (PRS).	Proline	61-68	NCK adaptor protein 1	Homo sapiens	46-49
33917542-8	2021	It prefers the cis configuration of the serine-proline motif within its substrate and regulates Pin1, different from other phosphatases.	Proline	47-54	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	96-100
33460563-7	2021	Recombinant human CCL1 promoted ESCC cell motility via the Akt/proline-rich Akt substrate of 40 kDa (PRAS40)/mammalian target of rapamycin (mTOR) pathway.	Proline	63-70	mechanistic target of rapamycin kinase	Homo sapiens	109-138
33637563-9	2021	The adjacent proline-enriched region connects the CNG channel to photoreceptor disc rims, likely through an interaction with peripherin-2.	Proline	13-20	peripherin 2	Mus musculus	125-137
33852894-3	2021	We find that DPF-3, a P-granule-localized N-terminal dipeptidase orthologous to mammalian dipeptidyl peptidase (DPP) 8/9, processes the unusually proline-rich N termini of WAGO-1 and WAGO-3 Argonaute (Ago) proteins.	Proline	146-153	double PHD fingers 3	Homo sapiens	13-18
33852894-3	2021	We find that DPF-3, a P-granule-localized N-terminal dipeptidase orthologous to mammalian dipeptidyl peptidase (DPP) 8/9, processes the unusually proline-rich N termini of WAGO-1 and WAGO-3 Argonaute (Ago) proteins.	Proline	146-153	dipeptidyl peptidase 8	Homo sapiens	90-120
33460563-7	2021	Recombinant human CCL1 promoted ESCC cell motility via the Akt/proline-rich Akt substrate of 40 kDa (PRAS40)/mammalian target of rapamycin (mTOR) pathway.	Proline	63-70	AKT1 substrate 1	Homo sapiens	101-107
33045291-1	2021	Prolidase is a metal-dependent peptidase specialized in the cleavage of dipeptides containing proline or hydroxyproline on their C-termini.	Proline	94-101	peptidase D	Homo sapiens	0-9
33596443-0	2021	A novel proline substitution (Arg201Pro) in alpha helix 8 of TMEM98 causes autosomal dominant nanophthalmos-4, closed angle glaucoma and attenuated visual acuity.	Proline	8-15	transmembrane protein 98	Homo sapiens	61-67
33263927-1	2021	Death-associated protein 1 (DAP1) is a proline-rich cytoplasmatic protein highly conserved in most eukaryotes.	Proline	39-46	death associated protein	Homo sapiens	0-26
33263927-1	2021	Death-associated protein 1 (DAP1) is a proline-rich cytoplasmatic protein highly conserved in most eukaryotes.	Proline	39-46	death associated protein	Homo sapiens	28-32
33415569-4	2021	The presence of Trypsin-1 pro-peptide sequence does not affect the function of secreted human Interleukin-25.	Proline	26-29	serine protease 1	Homo sapiens	16-25
33415569-5	2021	CONCLUSION: The Trypsin-1 signal peptide-pro-peptide sequence increased human IL-25 expression and secretion in mammalian cells by fivefold.	Proline	41-44	serine protease 1	Homo sapiens	16-25
33415569-5	2021	CONCLUSION: The Trypsin-1 signal peptide-pro-peptide sequence increased human IL-25 expression and secretion in mammalian cells by fivefold.	Proline	41-44	interleukin 25	Homo sapiens	78-83
33903307-10	2021	Mutation analysis which was done 70 months after commencement of nilotinib showed the presence of BCRABL1 kinase domain mutation with nucleotide substitution at position 1187 from Histidine(H) to Proline(P) (H396P).	Proline	196-203	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	98-105
33245199-1	2021	HLA-B*40:468 showed one nucleotide difference compared to HLA-B*40:06:01:01 at position 80 (A>C) Histidine to Proline residue 3.	Proline	110-117	major histocompatibility complex, class I, B	Homo sapiens	0-5
33245199-1	2021	HLA-B*40:468 showed one nucleotide difference compared to HLA-B*40:06:01:01 at position 80 (A>C) Histidine to Proline residue 3.	Proline	110-117	major histocompatibility complex, class I, B	Homo sapiens	58-63
33833463-3	2021	Here, we find that decreasing mitochondrial NADP(H) levels through depletion of NAD kinase 2 (NADK2), an enzyme responsible for production of mitochondrial NADP+, renders cells uniquely proline auxotrophic.	Proline	186-193	NAD kinase 2, mitochondrial	Homo sapiens	80-92
33833463-6	2021	Notably, after NADK2 deletion, proline is required to support nucleotide and protein synthesis, making proline essential for the growth and proliferation of NADK2-deficient cells.	Proline	103-110	NAD kinase 2, mitochondrial	Homo sapiens	157-162
33833463-7	2021	Thus, we highlight proline auxotrophy in mammalian cells and discover that mitochondrial NADPH is essential to enable proline biosynthesis.	Proline	118-125	2,4-dienoyl-CoA reductase 1	Homo sapiens	89-94
33833463-3	2021	Here, we find that decreasing mitochondrial NADP(H) levels through depletion of NAD kinase 2 (NADK2), an enzyme responsible for production of mitochondrial NADP+, renders cells uniquely proline auxotrophic.	Proline	186-193	NAD kinase 2, mitochondrial	Homo sapiens	94-99
33833464-0	2021	Mitochondrial NADPH is a pro at Pro synthesis.	Proline	25-28	2,4-dienoyl-CoA reductase 1	Homo sapiens	14-19
33833464-0	2021	Mitochondrial NADPH is a pro at Pro synthesis.	Proline	32-35	2,4-dienoyl-CoA reductase 1	Homo sapiens	14-19
33833463-4	2021	Cells with NADK2 deletion fail to synthesize proline, due to mitochondrial NADPH deficiency.	Proline	45-52	NAD kinase 2, mitochondrial	Homo sapiens	11-16
33833463-5	2021	We uncover the requirement of mitochondrial NADPH and NADK2 activity for the generation of the pyrroline-5-carboxylate metabolite intermediate as the bottleneck step in the proline biosynthesis pathway.	Proline	173-180	2,4-dienoyl-CoA reductase 1	Homo sapiens	44-49
33833463-5	2021	We uncover the requirement of mitochondrial NADPH and NADK2 activity for the generation of the pyrroline-5-carboxylate metabolite intermediate as the bottleneck step in the proline biosynthesis pathway.	Proline	173-180	NAD kinase 2, mitochondrial	Homo sapiens	54-59
33833463-6	2021	Notably, after NADK2 deletion, proline is required to support nucleotide and protein synthesis, making proline essential for the growth and proliferation of NADK2-deficient cells.	Proline	31-38	NAD kinase 2, mitochondrial	Homo sapiens	15-20
33833463-6	2021	Notably, after NADK2 deletion, proline is required to support nucleotide and protein synthesis, making proline essential for the growth and proliferation of NADK2-deficient cells.	Proline	31-38	NAD kinase 2, mitochondrial	Homo sapiens	157-162
33791697-5	2021	Inhibition of HS biosynthesis and SARS-CoV-2 infection depends on specific inhibition of PRS, possibly due to translational suppression of proline-rich proteins.	Proline	139-146	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	89-92
33196952-4	2021	Superoxide dismutase and catalase activities were increased by proline (1 mM) after 72 h, suggesting an increase in reactive species levels.	Proline	63-70	catalase	Homo sapiens	25-33
33196952-5	2021	Acetylcholinesterase activity was inhibited by proline at 1, 3, and 5 mM.	Proline	47-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
33196952-7	2021	Results from Western blot analyses showed that proline at 1 mM after 72 h increased p-NF-kB and decreased acetylcholinesterase immunocontent but did not altered AKT, p-AKT, GSK3beta, and p-GSK3beta.	Proline	47-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-126
33196952-7	2021	Results from Western blot analyses showed that proline at 1 mM after 72 h increased p-NF-kB and decreased acetylcholinesterase immunocontent but did not altered AKT, p-AKT, GSK3beta, and p-GSK3beta.	Proline	47-54	glycogen synthase kinase 3 alpha	Homo sapiens	189-197
33196952-8	2021	Taken together, the data suggest that high proline levels seems to favor the signaling pathways towards cell proliferation, since acetylcholinesterase, which may act as tumor suppressor, is inhibited by proline.	Proline	43-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	130-150
33196952-8	2021	Taken together, the data suggest that high proline levels seems to favor the signaling pathways towards cell proliferation, since acetylcholinesterase, which may act as tumor suppressor, is inhibited by proline.	Proline	203-210	acetylcholinesterase (Cartwright blood group)	Homo sapiens	130-150
33196952-9	2021	Also, p-NF-kappaB is increased by proline treatment and its activation is related to tumor cell proliferation and cellular response to oxidants.	Proline	34-41	nuclear factor kappa B subunit 1	Homo sapiens	8-17
33503568-3	2021	Omega-3 and omega-6 fatty acids can be converted into bioactive epoxides by cytochrome P450s (CYP450), which play pro-resolving roles in the inflammatory response; however, soluble epoxide hydrolase (sEH) metabolizes epoxides into diols, which lack pro-resolving functions and can be cytotoxic.	Proline	114-117	epoxide hydrolase 2	Homo sapiens	173-198
33503568-3	2021	Omega-3 and omega-6 fatty acids can be converted into bioactive epoxides by cytochrome P450s (CYP450), which play pro-resolving roles in the inflammatory response; however, soluble epoxide hydrolase (sEH) metabolizes epoxides into diols, which lack pro-resolving functions and can be cytotoxic.	Proline	114-117	epoxide hydrolase 2	Homo sapiens	200-203
33503568-3	2021	Omega-3 and omega-6 fatty acids can be converted into bioactive epoxides by cytochrome P450s (CYP450), which play pro-resolving roles in the inflammatory response; however, soluble epoxide hydrolase (sEH) metabolizes epoxides into diols, which lack pro-resolving functions and can be cytotoxic.	Proline	249-252	epoxide hydrolase 2	Homo sapiens	173-198
33503568-3	2021	Omega-3 and omega-6 fatty acids can be converted into bioactive epoxides by cytochrome P450s (CYP450), which play pro-resolving roles in the inflammatory response; however, soluble epoxide hydrolase (sEH) metabolizes epoxides into diols, which lack pro-resolving functions and can be cytotoxic.	Proline	249-252	epoxide hydrolase 2	Homo sapiens	200-203
33830435-3	2021	One of three Pyrroline-5-carboxylate reductases (PYCR), is primarily involved in conversion of glutamate to proline.	Proline	108-115	pyrroline-5-carboxylate reductase 1	Homo sapiens	49-53
33791697-6	2021	We find that pp1a and pp1ab polyproteins of SARS-CoV-2, as well as several HS proteoglycans, are proline-rich, which may make them particularly vulnerable to halofuginone"s translational suppression.	Proline	97-104	protein phosphatase 1 catalytic subunit alpha	Homo sapiens	13-17
33663205-4	2021	It has been shown that pS202/pT205/pS208 triple phosphorylations located in the proline-rich region can promote tau aggregation.	Proline	80-87	microtubule associated protein tau	Homo sapiens	112-115
33737524-6	2021	In comparison to untreated controls, treatment of EJ28Luc cells with 213Bi-anti-EGFR-MAb resulted in a significantly decreased incorporation of 13C from [U-13C6]glucose into alanine, aspartate, glutamate, glycine, proline and serine.	Proline	214-221	epidermal growth factor receptor	Homo sapiens	80-84
33649182-7	2021	Logistic regression analysis identified amino acid position 7 in the G-BETA domain of HLA-DRB1 as strongly associated with HAM/TSP (P = 9.52 x 10-10); individuals homozygous for leucine had an associated increased risk of HAM/TSP (odds ratio, 9.57), and proline was protective (odds ratio, 0.65).	Proline	254-261	major histocompatibility complex, class II, DR beta 1	Homo sapiens	86-94
33729478-7	2021	Results demonstrate that cyclin F closely associates with proteins involved with RNA metabolism as well as a number of RNA binding proteins previously linked to ALS/FTD, including splicing factor proline and glutamine rich (SFPQ).	Proline	196-203	cyclin F	Homo sapiens	25-33
33721894-7	2021	In addition, proline biosynthesis and catabolism were enhanced following KLU overexpression owing to increased expression of genes associated with proline metabolism.	Proline	13-20	cytochrome P450, family 78, subfamily A, polypeptide 5	Arabidopsis thaliana	73-76
33581552-0	2021	Multitargeting application of proline-derived peptidomimetics addressing cancer-related human matrix metalloproteinase 9 and carbonic anhydrase II.	Proline	30-37	matrix metallopeptidase 9	Homo sapiens	94-120
33581552-0	2021	Multitargeting application of proline-derived peptidomimetics addressing cancer-related human matrix metalloproteinase 9 and carbonic anhydrase II.	Proline	30-37	carbonic anhydrase 2	Homo sapiens	125-146
33721894-7	2021	In addition, proline biosynthesis and catabolism were enhanced following KLU overexpression owing to increased expression of genes associated with proline metabolism.	Proline	147-154	cytochrome P450, family 78, subfamily A, polypeptide 5	Arabidopsis thaliana	73-76
33721894-9	2021	Collectively, our work illustrates a role for KLU in positively regulating leaf longevity and drought tolerance by synergistically activating cytokinin signaling and promoting proline metabolism.	Proline	176-183	cytochrome P450, family 78, subfamily A, polypeptide 5	Arabidopsis thaliana	46-49
32491060-5	2021	The ckb3 mutant had more stomatal opening and increased proline accumulation and leaf water loss.	Proline	56-63	casein kinase II beta chain 3	Arabidopsis thaliana	4-8
33556623-1	2021	The PWWP domain was first identified in the HDGF protein family and named after the conserved Proline-Tryptophan-Tryptophan-Proline motif in WHSC1.	Proline	94-101	nuclear receptor binding SET domain protein 2	Homo sapiens	141-146
33556623-1	2021	The PWWP domain was first identified in the HDGF protein family and named after the conserved Proline-Tryptophan-Tryptophan-Proline motif in WHSC1.	Proline	124-131	nuclear receptor binding SET domain protein 2	Homo sapiens	141-146
33022038-8	2021	In addition, we find frequent glutamine to proline changes that help maintain the unstructured state of FUS that is necessary for phase separation.	Proline	43-50	FUS RNA binding protein	Homo sapiens	104-107
33653892-4	2021	Exchange of K986 and V987 for prolines has been shown to stabilize the trimers of SARS-CoV-1 and the Middle East respiratory syndrome coronavirus spike proteins.	Proline	30-38	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	146-151
33529484-4	2021	Molecular docking and molecular dynamics simulations suggest that interactions with Glu 39, Glu 78, Arg 111, Pro 137, Asp 251 and His 252 are an important factor for inhibitors affinity toward the DNase I.	Proline	109-112	deoxyribonuclease 1	Homo sapiens	197-204
33137372-6	2021	Here we apply SILCS-Biologics on a Fab domain of a monoclonal antibody (mAbN) to model Fab-Fab interactions and interactions with three amino acid excipients, namely, arginine HCl, proline and lysine HCl.	Proline	181-188	FA complementation group B	Homo sapiens	87-90
33137372-6	2021	Here we apply SILCS-Biologics on a Fab domain of a monoclonal antibody (mAbN) to model Fab-Fab interactions and interactions with three amino acid excipients, namely, arginine HCl, proline and lysine HCl.	Proline	181-188	FA complementation group B	Homo sapiens	87-90
33717117-1	2021	Pin1 is the only known peptidyl-prolyl cis-trans isomerase (PPIase) that can specifically recognize and isomerize the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) motif, change the conformation of proteins through protein phosphorylation, thus regulate various cellular processes in the body.	Proline	150-157	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
33627783-9	2021	Inhibition of the CBL-CIN85 interaction with a proline-rich peptide of CBL that binds CIN85 reduced the proliferation of MDA-MB-231 cells.	Proline	47-54	Cbl proto-oncogene	Homo sapiens	18-21
33627783-9	2021	Inhibition of the CBL-CIN85 interaction with a proline-rich peptide of CBL that binds CIN85 reduced the proliferation of MDA-MB-231 cells.	Proline	47-54	SH3 domain containing kinase binding protein 1	Homo sapiens	22-27
33627783-9	2021	Inhibition of the CBL-CIN85 interaction with a proline-rich peptide of CBL that binds CIN85 reduced the proliferation of MDA-MB-231 cells.	Proline	47-54	Cbl proto-oncogene	Homo sapiens	71-74
33627783-9	2021	Inhibition of the CBL-CIN85 interaction with a proline-rich peptide of CBL that binds CIN85 reduced the proliferation of MDA-MB-231 cells.	Proline	47-54	SH3 domain containing kinase binding protein 1	Homo sapiens	86-91
33626482-5	2021	In addition, we further highlighted under osmotic stress conditions that cry1a increased tomato growth by reduced malondialdehyde (MDA) and proline accumulation.	Proline	140-147	cryptochrome 1	Solanum lycopersicum	73-78
33083964-1	2021	The peptidyl-prolyl isomerase Pin1 is a unique enzyme catalyzing the isomerization of the peptide bond between phosphorylated serine-proline or threonine-proline motifs in proteins, thereby regulating a wide spectrum of protein functions, including folding, intracellular signaling, transcription, cell cycle progression, and apoptosis.	Proline	133-140	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	30-34
33083964-1	2021	The peptidyl-prolyl isomerase Pin1 is a unique enzyme catalyzing the isomerization of the peptide bond between phosphorylated serine-proline or threonine-proline motifs in proteins, thereby regulating a wide spectrum of protein functions, including folding, intracellular signaling, transcription, cell cycle progression, and apoptosis.	Proline	154-161	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	30-34
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	26-33	pyrroline-5-carboxylate reductase 1	Homo sapiens	91-96
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	26-33	aldehyde dehydrogenase 18 family member A1	Homo sapiens	102-144
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	26-33	aldehyde dehydrogenase 18 family member A1	Homo sapiens	146-154
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	26-33	proline dehydrogenase 1	Homo sapiens	263-284
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	26-33	proline dehydrogenase 1	Homo sapiens	286-291
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	228-235	pyrroline-5-carboxylate reductase 1	Homo sapiens	91-96
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	228-235	aldehyde dehydrogenase 18 family member A1	Homo sapiens	102-144
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	228-235	aldehyde dehydrogenase 18 family member A1	Homo sapiens	146-154
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	228-235	proline dehydrogenase 1	Homo sapiens	263-284
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	228-235	proline dehydrogenase 1	Homo sapiens	286-291
33320198-16	2021	The odds of fast AMH decline was increased with higher serum metabolites of phosphate, N-acetyl-d-glucosamine, BCAAs, proline, urea and pyroglutamic acid.	Proline	118-125	anti-Mullerian hormone	Homo sapiens	17-20
33576622-3	2021	This work brings together two structural elements that direct nanoscale self-association in divergent directions: proline as a beta-breaker and the beta-structure-associated diphenylalanine motif, into a single tripeptide sequence.	Proline	114-121	amyloid beta precursor protein	Homo sapiens	125-131
33606679-2	2021	In addition to a canonical cyclophilin (Cyp) domain, Cyp33 contains an RNA-recognition motif (RRM) domain, and RNA-binding triggers proline isomerase activity.	Proline	132-139	peptidylprolyl isomerase G	Homo sapiens	27-38
33606679-2	2021	In addition to a canonical cyclophilin (Cyp) domain, Cyp33 contains an RNA-recognition motif (RRM) domain, and RNA-binding triggers proline isomerase activity.	Proline	132-139	peptidylprolyl isomerase E	Homo sapiens	53-58
33606679-4	2021	MLL activity is regulated by Cyp33, which isomerizes a key proline in the linker between the PHD3 and Bromo domains of MLL1, acting as a switch between gene activation and repression.	Proline	59-66	lysine methyltransferase 2A	Homo sapiens	0-3
33606679-4	2021	MLL activity is regulated by Cyp33, which isomerizes a key proline in the linker between the PHD3 and Bromo domains of MLL1, acting as a switch between gene activation and repression.	Proline	59-66	peptidylprolyl isomerase E	Homo sapiens	29-34
33606679-4	2021	MLL activity is regulated by Cyp33, which isomerizes a key proline in the linker between the PHD3 and Bromo domains of MLL1, acting as a switch between gene activation and repression.	Proline	59-66	egl-9 family hypoxia inducible factor 3	Homo sapiens	93-97
33606679-4	2021	MLL activity is regulated by Cyp33, which isomerizes a key proline in the linker between the PHD3 and Bromo domains of MLL1, acting as a switch between gene activation and repression.	Proline	59-66	lysine methyltransferase 2A	Homo sapiens	119-123
33333077-0	2021	Structural analysis of prolines and hydroxyprolines binding to the l-glutamate-gamma-semialdehyde dehydrogenase active site of bifunctional proline utilization A.	Proline	23-31	aldehyde dehydrogenase 4 family member A1	Homo sapiens	67-111
33333077-0	2021	Structural analysis of prolines and hydroxyprolines binding to the l-glutamate-gamma-semialdehyde dehydrogenase active site of bifunctional proline utilization A.	Proline	23-30	aldehyde dehydrogenase 4 family member A1	Homo sapiens	67-111
33594155-0	2021	Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer.	Proline	23-30	WASP family member 3	Homo sapiens	46-51
33333077-1	2021	Proline utilization A (PutA) proteins are bifunctional proline catabolic enzymes that catalyze the 4-electron oxidation of l-proline to l-glutamate using spatially-separated proline dehydrogenase and l-glutamate-gamma-semialdehyde dehydrogenase (GSALDH, a.k.a.	Proline	0-7	aldehyde dehydrogenase 4 family member A1	Homo sapiens	200-244
33594155-5	2021	Moreover, our recent study showed that the proline rich domain (PRD) of WAVE3 is required for maintenance of the CSC niche in breast cancer by regulating the nuclear translocation of the CSC-specific nuclear transcription factor YB1.	Proline	43-50	WASP family member 3	Homo sapiens	72-77
33333077-1	2021	Proline utilization A (PutA) proteins are bifunctional proline catabolic enzymes that catalyze the 4-electron oxidation of l-proline to l-glutamate using spatially-separated proline dehydrogenase and l-glutamate-gamma-semialdehyde dehydrogenase (GSALDH, a.k.a.	Proline	123-132	aldehyde dehydrogenase 4 family member A1	Homo sapiens	200-244
33333077-1	2021	Proline utilization A (PutA) proteins are bifunctional proline catabolic enzymes that catalyze the 4-electron oxidation of l-proline to l-glutamate using spatially-separated proline dehydrogenase and l-glutamate-gamma-semialdehyde dehydrogenase (GSALDH, a.k.a.	Proline	125-132	aldehyde dehydrogenase 4 family member A1	Homo sapiens	200-244
33594155-5	2021	Moreover, our recent study showed that the proline rich domain (PRD) of WAVE3 is required for maintenance of the CSC niche in breast cancer by regulating the nuclear translocation of the CSC-specific nuclear transcription factor YB1.	Proline	43-50	Y-box binding protein 1	Homo sapiens	229-232
33333077-1	2021	Proline utilization A (PutA) proteins are bifunctional proline catabolic enzymes that catalyze the 4-electron oxidation of l-proline to l-glutamate using spatially-separated proline dehydrogenase and l-glutamate-gamma-semialdehyde dehydrogenase (GSALDH, a.k.a.	Proline	55-62	aldehyde dehydrogenase 4 family member A1	Homo sapiens	200-244
33825882-4	2021	In this study, we have imparted collagenolytic property to cathepsin-L, by systematically engineering proline-specificity and glycosaminoglycans (GAG)-binding surface in the protease.	Proline	102-109	cathepsin L	Homo sapiens	59-70
33580145-2	2021	Several mutations that affect the proline-tyrosine nuclear localization signal (PY-NLS) of FUS cause severe juvenile ALS.	Proline	34-41	FUS RNA binding protein	Homo sapiens	91-94
33580260-5	2021	However, when Ser 487 at the corresponding position was converted back to proline, NRT1.13 S487P regained nitrate uptake activity, suggesting that wild-type NRT1.13 cannot transport nitrate but can bind it.	Proline	74-81	nitrate transporter 1.1	Arabidopsis thaliana	83-87
33480903-4	2021	The 0 K BDE for PrO+ is determined to be 7.62 +- 0.09 eV from the weighted average of five independent thresholds.	Proline	16-20	homeobox D13	Homo sapiens	8-11
33563616-9	2021	Raman spectroscopy confirmed the effect on collagen was linked to molecular dimorphic VEGF effects on collagen-specific proline and hydroxyproline, and collagen intra-stand stability, in addition to matrix carbonation and mineralisation.	Proline	120-127	vascular endothelial growth factor A	Mus musculus	86-90
33564758-2	2021	Here, we show that O-glycosylation near the furin cleavage site is mediated by specific members of the GALNT enzyme family and is dependent on the novel proline at position 681 (P681).	Proline	153-160	furin, paired basic amino acid cleaving enzyme	Homo sapiens	44-49
33428810-3	2021	Here, we report that SLC6A20A, an amino acid transporter known to transport proline based on in vitro data but is understudied in the brain, regulates proline and glycine levels and NMDAR function in the mouse brain.	Proline	76-83	solute carrier family 6 (neurotransmitter transporter), member 20A	Mus musculus	21-29
33428810-3	2021	Here, we report that SLC6A20A, an amino acid transporter known to transport proline based on in vitro data but is understudied in the brain, regulates proline and glycine levels and NMDAR function in the mouse brain.	Proline	76-83	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	182-187
33428810-3	2021	Here, we report that SLC6A20A, an amino acid transporter known to transport proline based on in vitro data but is understudied in the brain, regulates proline and glycine levels and NMDAR function in the mouse brain.	Proline	151-158	solute carrier family 6 (neurotransmitter transporter), member 20A	Mus musculus	21-29
33428810-8	2021	Lastly, both mouse and human SLC6A20 proteins mediated proline and glycine transports, and SLC6A20 proteins could be detected in human neurons.	Proline	55-62	solute carrier family 6 member 20	Homo sapiens	29-36
33428810-9	2021	These results suggest that SLC6A20 regulates proline and glycine homeostasis in the brain and that SLC6A20 inhibition has therapeutic potential for brain disorders involving NMDAR hypofunction.	Proline	45-52	solute carrier family 6 member 20	Homo sapiens	27-34
33482102-4	2021	Moreover, we characterized proline-induced cells (PiCs), a LIF-dependent reversible early-primed state of pluripotency, and show that PiCs are able to generate gastruloids (GFE ~ 50%) and are also competent to differentiate into primordial germ cell-like cells.	Proline	27-34	leukemia inhibitory factor	Mus musculus	59-62
33529338-3	2021	Here, an Arabidopsis intergenic enhancer double mutant, namely proline content alterative 41 (pca41), was generated by inserting a T-DNA tag in the Arabidopsis thaliana ring zinc finger 1 (atrzf1 ) mutant background.	Proline	63-70	RING/U-box superfamily protein	Arabidopsis thaliana	189-195
33557922-4	2021	eIF5A is a specific translation factor that is especially required for the formation of peptide bond between certain residues including proline regarded as poor substrates for slow peptide bond formation.	Proline	136-143	eukaryotic elongation factor 5A-1	Arabidopsis thaliana	0-5
33536208-5	2021	A conserved proline between neck coil-coiled-coil (NC-CC1) domains of KIF13A creates steric hindrance, rendering the motors as inactive monomers.	Proline	12-19	kinesin family member 13A	Homo sapiens	70-76
33536208-6	2021	Rab22A plays an unusual role by binding to NC-CC1 domains of KIF13A, relieving proline-mediated inhibition and facilitating motor dimerization.	Proline	79-86	RAB22A, member RAS oncogene family	Homo sapiens	0-6
33536208-6	2021	Rab22A plays an unusual role by binding to NC-CC1 domains of KIF13A, relieving proline-mediated inhibition and facilitating motor dimerization.	Proline	79-86	kinesin family member 13A	Homo sapiens	61-67
33335079-7	2021	In deletion mutant analyses, large portions of the TDAG51 domains, including the pleckstrin homology-like, glutamine repeat and prolineglutamine repeat domains but not the proline-histidine repeat domain, are involved in the interaction with the region between residues 140 and 506, including the DNA binding domain, hinge, ligand binding domain and activation function-2 domain, in PPARgamma.	Proline	128-135	pleckstrin homology like domain, family A, member 1	Mus musculus	51-57
33333173-5	2021	(a) A metalloprotease (alveolin) hydrolyzes the N-terminal proline-glutamine (Pro-Gln) region of zona pellucida (ZP) 1 and (b) triggers intermolecular cross-linking to ZP3 catalyzed by transglutaminase (TGase).	Proline	59-66	transglutaminase 1	Homo sapiens	203-208
32780150-0	2021	ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs.	Proline	76-83	intersectin 1	Homo sapiens	0-5
32780150-0	2021	ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs.	Proline	76-83	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	16-21
32780150-0	2021	ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs.	Proline	76-83	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	70-75
32780150-2	2021	We found that intersectin 1 (ITSN1), a multidomain scaffold protein harboring five soluble SH3 domains, interacts with SAM68 proline-rich motifs (PRMs) surrounded by self-adhesive low complexity domains.	Proline	125-132	intersectin 1	Homo sapiens	14-27
32780150-2	2021	We found that intersectin 1 (ITSN1), a multidomain scaffold protein harboring five soluble SH3 domains, interacts with SAM68 proline-rich motifs (PRMs) surrounded by self-adhesive low complexity domains.	Proline	125-132	intersectin 1	Homo sapiens	29-34
32780150-2	2021	We found that intersectin 1 (ITSN1), a multidomain scaffold protein harboring five soluble SH3 domains, interacts with SAM68 proline-rich motifs (PRMs) surrounded by self-adhesive low complexity domains.	Proline	125-132	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	119-124
33333173-5	2021	(a) A metalloprotease (alveolin) hydrolyzes the N-terminal proline-glutamine (Pro-Gln) region of zona pellucida (ZP) 1 and (b) triggers intermolecular cross-linking to ZP3 catalyzed by transglutaminase (TGase).	Proline	59-66	zona pellucida glycoprotein 1	Homo sapiens	97-126
33333173-5	2021	(a) A metalloprotease (alveolin) hydrolyzes the N-terminal proline-glutamine (Pro-Gln) region of zona pellucida (ZP) 1 and (b) triggers intermolecular cross-linking to ZP3 catalyzed by transglutaminase (TGase).	Proline	59-66	zona pellucida glycoprotein 3	Homo sapiens	168-171
33333173-5	2021	(a) A metalloprotease (alveolin) hydrolyzes the N-terminal proline-glutamine (Pro-Gln) region of zona pellucida (ZP) 1 and (b) triggers intermolecular cross-linking to ZP3 catalyzed by transglutaminase (TGase).	Proline	59-66	transglutaminase 1	Homo sapiens	185-201
33358613-4	2021	We found that adamantane-derived compounds bind to the insulin receptor more effectively (Kd value of 0.5 muM) than proline-derived compounds (Kd values of 15-38 muM) bearing the same peptides.	Proline	116-123	insulin receptor	Homo sapiens	55-71
33332208-7	2021	These modules, sharing three lncRNAs (GS1-358P8.4, OIP5-AS1, and RP11-690D19.3), were significantly enriched in biological pathways such as regulation of actin cytoskeleton, tryptophan metabolism, lysosome, and arginine and proline metabolism.	Proline	224-231	pyruvate dehydrogenase kinase 3	Homo sapiens	38-49
33332208-7	2021	These modules, sharing three lncRNAs (GS1-358P8.4, OIP5-AS1, and RP11-690D19.3), were significantly enriched in biological pathways such as regulation of actin cytoskeleton, tryptophan metabolism, lysosome, and arginine and proline metabolism.	Proline	224-231	OIP5 antisense RNA 1	Homo sapiens	51-59
33332208-7	2021	These modules, sharing three lncRNAs (GS1-358P8.4, OIP5-AS1, and RP11-690D19.3), were significantly enriched in biological pathways such as regulation of actin cytoskeleton, tryptophan metabolism, lysosome, and arginine and proline metabolism.	Proline	224-231	pre-mRNA processing factor 31	Homo sapiens	65-69
33369793-14	2021	Immunoblotting assays showed that the phosphorylation levels of AMP-activated protein kinase, a rate-limiting factor in insulin-independent signaling, and that of liver kinase B1, an upstream factor of AMP-activated protein kinase, in both milk casein hydrolysate and isoleucine-proline-proline-treated cells were higher than those in the control cells.	Proline	279-286	insulin	Homo sapiens	120-127
33369793-14	2021	Immunoblotting assays showed that the phosphorylation levels of AMP-activated protein kinase, a rate-limiting factor in insulin-independent signaling, and that of liver kinase B1, an upstream factor of AMP-activated protein kinase, in both milk casein hydrolysate and isoleucine-proline-proline-treated cells were higher than those in the control cells.	Proline	287-294	insulin	Homo sapiens	120-127
33369793-17	2021	The findings of our study suggest that milk casein hydrolysate enhances glucose uptake by activating insulin-independent AMP-activated protein kinase signaling in skeletal muscle cells, which might be mediated by a milk casein hydrolysate-derived peptide, namely, isoleucine-proline-proline.	Proline	275-282	insulin	Homo sapiens	101-108
33369793-17	2021	The findings of our study suggest that milk casein hydrolysate enhances glucose uptake by activating insulin-independent AMP-activated protein kinase signaling in skeletal muscle cells, which might be mediated by a milk casein hydrolysate-derived peptide, namely, isoleucine-proline-proline.	Proline	283-290	insulin	Homo sapiens	101-108
33627283-6	2021	L-proline at 50 mug/mL and 100 mug/mL increased caspase 3/7 activity at both 41  C and 43  C, however it was less augmented at all the concentrations at 45  C. Glutathione level was decreased in heat-stressed (at 43  C and 45  C) hen erythrocytes treated with L-proline (at 50 mug/mL and 100 mug/mL) but it was increased at 200 mug/mL.	Proline	0-9	caspase 3	Homo sapiens	48-59
33487341-7	2021	The content of proline and activities of superoxide dismutase and peroxidase in knockdown lines were higher than in the wild type and overexpression lines during chilling stress.	Proline	15-22	peroxidase	Solanum lycopersicum	66-76
33465163-9	2021	MYCN-cluster cases showed high expression of ALDH18A1, encoding P5CS related to proline production.	Proline	80-87	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	0-4
33664850-10	2021	Results: PDK-1 in KRAS mutant CRC cells and murine xenografts was downregulated using pharmacological doses of vitamin C through the proline hydroxylation (Pro402) of the Hypoxia inducible factor-1(HIF-1)alpha, correlating with decreased expression of the glucose transporter 1 (GLUT-1) in both models.	Proline	133-140	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	9-14
33664850-10	2021	Results: PDK-1 in KRAS mutant CRC cells and murine xenografts was downregulated using pharmacological doses of vitamin C through the proline hydroxylation (Pro402) of the Hypoxia inducible factor-1(HIF-1)alpha, correlating with decreased expression of the glucose transporter 1 (GLUT-1) in both models.	Proline	133-140	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	18-22
33664850-10	2021	Results: PDK-1 in KRAS mutant CRC cells and murine xenografts was downregulated using pharmacological doses of vitamin C through the proline hydroxylation (Pro402) of the Hypoxia inducible factor-1(HIF-1)alpha, correlating with decreased expression of the glucose transporter 1 (GLUT-1) in both models.	Proline	133-140	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	256-277
33664850-10	2021	Results: PDK-1 in KRAS mutant CRC cells and murine xenografts was downregulated using pharmacological doses of vitamin C through the proline hydroxylation (Pro402) of the Hypoxia inducible factor-1(HIF-1)alpha, correlating with decreased expression of the glucose transporter 1 (GLUT-1) in both models.	Proline	133-140	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	279-285
33476259-2	2021	Here, we identify two factors, splicing factor proline/glutamine rich (SFPQ) and non-POU domain-containing octamer-binding protein (NONO), to be enriched around circRNA loci.	Proline	47-54	splicing factor proline and glutamine rich	Homo sapiens	71-75
33476259-2	2021	Here, we identify two factors, splicing factor proline/glutamine rich (SFPQ) and non-POU domain-containing octamer-binding protein (NONO), to be enriched around circRNA loci.	Proline	47-54	non-POU domain containing octamer binding	Homo sapiens	132-136
33494271-1	2021	The proline-specific serine protease fibroblast activation protein (FAP) can participate in the progression of malignant tumors and represents a potential diagnostic and therapeutic target.	Proline	4-11	fibroblast activation protein alpha	Homo sapiens	68-71
33463409-1	2021	The parvulin PIN1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1), is the only enzyme capable of isomerizing prolines of phospho-Serine/Threonine-Proline motifs.	Proline	118-126	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	13-17
33463409-1	2021	The parvulin PIN1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1), is the only enzyme capable of isomerizing prolines of phospho-Serine/Threonine-Proline motifs.	Proline	118-126	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	19-73
33463409-1	2021	The parvulin PIN1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1), is the only enzyme capable of isomerizing prolines of phospho-Serine/Threonine-Proline motifs.	Proline	155-162	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	13-17
33463409-1	2021	The parvulin PIN1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1), is the only enzyme capable of isomerizing prolines of phospho-Serine/Threonine-Proline motifs.	Proline	155-162	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	19-73
33465163-9	2021	MYCN-cluster cases showed high expression of ALDH18A1, encoding P5CS related to proline production.	Proline	80-87	aldehyde dehydrogenase 18 family member A1	Homo sapiens	45-53
33465163-9	2021	MYCN-cluster cases showed high expression of ALDH18A1, encoding P5CS related to proline production.	Proline	80-87	aldehyde dehydrogenase 18 family member A1	Homo sapiens	64-68
33316155-3	2021	Human ornithine aminotransferase (hOAT) is a pyridoxal-5"-phosphate (PLP)-dependent enzyme involved in glutamine and proline metabolism.	Proline	117-124	ornithine aminotransferase	Homo sapiens	34-38
33458942-0	2021	The role of prolines and glycine in the transmembrane domain of LAT.	Proline	12-20	linker for activation of T cells	Homo sapiens	64-67
33458942-4	2021	Here, we studied the impact of helix-breaking amino acids, two prolines and one glycine, in the transmembrane segment on localisation and function of LAT.	Proline	63-71	linker for activation of T cells	Homo sapiens	150-153
33458942-6	2021	The helical structure and dynamics are further regulated by glycine and another proline residue in the luminal part of LAT transmembrane domain.	Proline	80-87	linker for activation of T cells	Homo sapiens	119-122
33467043-9	2021	The key differences revealed by our structural study show that the canonical binding groove found in typical SH3 domains accommodating proline-rich motifs is missing in Caskin1 SH3, most likely excluding a bona fide protein target for the domain.	Proline	135-142	CASK interacting protein 1	Homo sapiens	169-176
33537091-1	2021	Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis.	Proline	121-128	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
33537316-8	2020	Here, we report the crystal structure of the EFhd1 core domain comprising a C-terminus of a proline-rich region, two EF-hand domains, and a ligand mimic helix.	Proline	92-99	EF-hand domain family member D1	Homo sapiens	45-50
33452693-9	2021	NMR spectroscopy reveals that the interaction of the carboxy-terminal domain of alpha-synuclein with the proline-rich region P2 of tau is required for the recruitment of alpha-synuclein into tau droplets.	Proline	105-112	synuclein alpha	Homo sapiens	80-95
33452693-9	2021	NMR spectroscopy reveals that the interaction of the carboxy-terminal domain of alpha-synuclein with the proline-rich region P2 of tau is required for the recruitment of alpha-synuclein into tau droplets.	Proline	105-112	microtubule associated protein tau	Homo sapiens	131-134
33452693-9	2021	NMR spectroscopy reveals that the interaction of the carboxy-terminal domain of alpha-synuclein with the proline-rich region P2 of tau is required for the recruitment of alpha-synuclein into tau droplets.	Proline	105-112	synuclein alpha	Homo sapiens	170-185
33452693-9	2021	NMR spectroscopy reveals that the interaction of the carboxy-terminal domain of alpha-synuclein with the proline-rich region P2 of tau is required for the recruitment of alpha-synuclein into tau droplets.	Proline	105-112	microtubule associated protein tau	Homo sapiens	191-194
33837725-11	2021	Furthermore, we show that the C-terminal portion of the Serine-Threonine-Proline-rich (STP) region, adjacent to the GAIN domain, was required for Src-Fak activation.	Proline	73-80	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	146-149
33352047-1	2021	We optimized our previously reported proline-based STAT3 inhibitors into an exciting new series of (R)-azetidine-2-carboxamide analogues that have sub-micromolar potencies.	Proline	37-44	signal transducer and activator of transcription 3	Homo sapiens	51-56
33459229-2	2021	The over activation of GSK-3, an enzyme from the proline/serine Ki NS family, has been associated with hyper-phosphorylation of tau proteins.	Proline	49-56	microtubule associated protein tau	Homo sapiens	128-131
33446840-8	2021	However, METH exposure resulted in a significant upregulation of pyrroline-5-carboxylate synthase (P5CS), the key enzyme that catalyzes synthesis of proline from glutamate.	Proline	149-156	aldehyde dehydrogenase 18 family, member A1	Mus musculus	65-97
33446840-8	2021	However, METH exposure resulted in a significant upregulation of pyrroline-5-carboxylate synthase (P5CS), the key enzyme that catalyzes synthesis of proline from glutamate.	Proline	149-156	aldehyde dehydrogenase 18 family, member A1	Mus musculus	99-103
33446840-10	2021	METH exposure also increased glutamate levels in P5CS-deficient proline-auxotropic cells.	Proline	64-71	aldehyde dehydrogenase 18 family, member A1	Mus musculus	49-53
33428936-1	2021	Proline and arginine-rich end leucine-rich repeat protein (PRELP) is a member of the small leucine-rich repeat proteoglycans (SLRPs) family.	Proline	0-7	proline and arginine rich end leucine rich repeat protein	Homo sapiens	59-64
33837725-11	2021	Furthermore, we show that the C-terminal portion of the Serine-Threonine-Proline-rich (STP) region, adjacent to the GAIN domain, was required for Src-Fak activation.	Proline	73-80	protein tyrosine kinase 2	Homo sapiens	150-153
33346272-0	2021	Proline isomerization effects in the amyloidogenic protein beta2-microglobulin.	Proline	0-7	beta-2-microglobulin	Homo sapiens	59-78
33413684-7	2021	In particular, serine, glycine, and proline metabolism, and the anabolic potential of the cell, were sensitive to PEPCK-M activity.	Proline	36-43	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	114-121
32950106-7	2021	NONO directly interacted with splicing factor proline/glutamine rich (SFPQ) to regulate the splicing of SETMAR, and it induced metastasis suppression of bladder cancer cells.	Proline	46-53	non-POU domain containing octamer binding	Homo sapiens	0-4
32950106-7	2021	NONO directly interacted with splicing factor proline/glutamine rich (SFPQ) to regulate the splicing of SETMAR, and it induced metastasis suppression of bladder cancer cells.	Proline	46-53	splicing factor proline and glutamine rich	Homo sapiens	70-74
32950106-7	2021	NONO directly interacted with splicing factor proline/glutamine rich (SFPQ) to regulate the splicing of SETMAR, and it induced metastasis suppression of bladder cancer cells.	Proline	46-53	SET domain and mariner transposase fusion gene	Homo sapiens	104-110
33346272-3	2021	A potential, although debated, triggering factor is the cis to trans isomerization of a specific proline (Pro32) in beta2-m.	Proline	97-104	alpha-2-macroglobulin	Homo sapiens	116-123
32815823-2	2021	Prolidase is a metalloprotease found in various tissues, which has been associated with the concentrations of proline, a neurotransmitter, in the brain.	Proline	110-117	peptidase D	Homo sapiens	0-9
33439085-0	2021	Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair.	Proline	51-58	activation induced cytidine deaminase	Homo sapiens	84-87
33680370-8	2021	Regarding beta subunit, proline rich loop and projection domain actively participated in tau binding.	Proline	24-31	microtubule associated protein tau	Homo sapiens	89-92
33680370-10	2021	Conclusion: This study being the first of its kind emphasizes the role of projection domain and proline rich region of beta-subunit in stabilizing the tau-tubulin interaction and also the effect of hyperphosphorylation in protein-protein and protein-drug binding.	Proline	96-103	microtubule associated protein tau	Homo sapiens	151-154
33129139-6	2021	Moreover, proline metabolism, glutathione metabolism, and PPAR signaling pathways were significantly enriched in the LFs versus SFs analysis; the associated genes, glutamate-cysteine ligase modifier subunit (GCLM) and cystathionine gamma-lyase (CTH), were significantly upregulated, whereas peroxisome proliferator-activated receptor gamma (PPARgamma) was significantly downregulated.	Proline	10-17	glutamate--cysteine ligase regulatory subunit	Ovis aries	164-206
33129139-6	2021	Moreover, proline metabolism, glutathione metabolism, and PPAR signaling pathways were significantly enriched in the LFs versus SFs analysis; the associated genes, glutamate-cysteine ligase modifier subunit (GCLM) and cystathionine gamma-lyase (CTH), were significantly upregulated, whereas peroxisome proliferator-activated receptor gamma (PPARgamma) was significantly downregulated.	Proline	10-17	glutamate--cysteine ligase regulatory subunit	Ovis aries	208-212
33129139-6	2021	Moreover, proline metabolism, glutathione metabolism, and PPAR signaling pathways were significantly enriched in the LFs versus SFs analysis; the associated genes, glutamate-cysteine ligase modifier subunit (GCLM) and cystathionine gamma-lyase (CTH), were significantly upregulated, whereas peroxisome proliferator-activated receptor gamma (PPARgamma) was significantly downregulated.	Proline	10-17	cystathionine gamma-lyase	Ovis aries	218-243
33129139-6	2021	Moreover, proline metabolism, glutathione metabolism, and PPAR signaling pathways were significantly enriched in the LFs versus SFs analysis; the associated genes, glutamate-cysteine ligase modifier subunit (GCLM) and cystathionine gamma-lyase (CTH), were significantly upregulated, whereas peroxisome proliferator-activated receptor gamma (PPARgamma) was significantly downregulated.	Proline	10-17	cystathionine gamma-lyase	Ovis aries	245-248
33129139-6	2021	Moreover, proline metabolism, glutathione metabolism, and PPAR signaling pathways were significantly enriched in the LFs versus SFs analysis; the associated genes, glutamate-cysteine ligase modifier subunit (GCLM) and cystathionine gamma-lyase (CTH), were significantly upregulated, whereas peroxisome proliferator-activated receptor gamma (PPARgamma) was significantly downregulated.	Proline	10-17	peroxisome proliferator-activated receptor gamma	Ovis aries	291-339
33129139-6	2021	Moreover, proline metabolism, glutathione metabolism, and PPAR signaling pathways were significantly enriched in the LFs versus SFs analysis; the associated genes, glutamate-cysteine ligase modifier subunit (GCLM) and cystathionine gamma-lyase (CTH), were significantly upregulated, whereas peroxisome proliferator-activated receptor gamma (PPARgamma) was significantly downregulated.	Proline	10-17	peroxisome proliferator-activated receptor gamma	Ovis aries	341-350
33601878-3	2021	In each module, genes with the most connectivity were selected as hub genes, including G antigen 12J (GAGE12J) in blue, proline, histidine and glycine rich 1 (PHGR1) in dark orange, DNA polymerase gamma 2, accessory subunit (POLG2) in dark red and collagen type XXI alpha 1 chain (COL21A1) in dark violet.	Proline	120-127	ELAV like RNA binding protein 2	Homo sapiens	66-69
32770108-1	2021	Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine.	Proline	135-142	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-32
32770108-1	2021	Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine.	Proline	135-142	aldehyde dehydrogenase 18 family member A1	Homo sapiens	34-38
33475951-7	2021	The characteristic 1H-13C chemical shift correlations of isoAsp, N-terminal Pro and C-terminal Asp under standardized conditions were used to identify these PTMs in lysozyme and in the therapeutic mAb rituximab (MabThera) upon prolonged storage under acidic conditions (pH 4-5) and 40  C. The results show that the application of our 2D NMR-based protocol is straightforward and allows detecting chemical changes of proteins that may be otherwise unnoticed with other analytical methods.	Proline	76-79	lysozyme	Homo sapiens	165-173
32835702-2	2021	The aim of the present study was to investigate, if 17-alpha-ethinyl-estradiol (E-E2) and 17-beta-estradiol (E) inhibit PAT1-mediated intestinal absorption of proline and taurine in vitro in Caco-2 cells and in vivo using Sprague-Dawley rats to assess the potential for taurine-drug interactions.	Proline	159-166	solute carrier family 36 member 1	Homo sapiens	120-124
32772173-10	2021	In AVS/AIS patients with suspected PCS, disabling vestibular symptoms, focal neurological deficits, and hypoperfusion on CTP seem to direct decision-making pro IVT.	Proline	156-159	PCS	Homo sapiens	35-38
32835702-3	2021	E and E-E2 inhibited the PAT1-mediated uptake of proline and taurine in Caco-2 cells with IC50 values of 10.0 - 50.0 muM without major effect on other solute carriers such as the taurine transporter (TauT), di/tri-peptide transporter (PEPT1), and serotonin transporter (SERT1).	Proline	49-56	solute carrier family 36 member 1	Homo sapiens	25-29
33318173-5	2020	Further, we identify the ABL2 tyrosine kinase as an upstream regulator of HSF1 protein expression and show that the Src-homology 3 (SH3) domain of ABL2 directly interacts with HSF1 protein at a noncanonical, proline-independent SH3 interaction motif.	Proline	208-215	heat shock transcription factor 1	Homo sapiens	74-78
34050860-2	2021	The structure of Calr is unusual, reflecting different functions of the protein: a proline-rich beta-hairpin arm and an acidic C-terminal tail protrude from a globular core, composed of a beta-sheet sandwich and an alpha-helix.	Proline	83-90	calreticulin	Homo sapiens	17-21
33268892-9	2021	Deep proteomics analysis identified ALDH4A1, a mitochondrial dehydrogenase involved in proline metabolism, as a target antigen of one of these autoantibodies, A12.	Proline	87-94	aldehyde dehydrogenase 4 family, member A1	Mus musculus	36-43
33409256-4	2020	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Pin1 changes the conformation of a subset of proteins phosphorylated on Ser/Thr that precedes proline (Pro).	Proline	150-157	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-54
33409256-4	2020	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Pin1 changes the conformation of a subset of proteins phosphorylated on Ser/Thr that precedes proline (Pro).	Proline	150-157	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	56-60
33409256-4	2020	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Pin1 changes the conformation of a subset of proteins phosphorylated on Ser/Thr that precedes proline (Pro).	Proline	159-162	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-54
33409256-4	2020	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Pin1 changes the conformation of a subset of proteins phosphorylated on Ser/Thr that precedes proline (Pro).	Proline	159-162	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	56-60
33318173-5	2020	Further, we identify the ABL2 tyrosine kinase as an upstream regulator of HSF1 protein expression and show that the Src-homology 3 (SH3) domain of ABL2 directly interacts with HSF1 protein at a noncanonical, proline-independent SH3 interaction motif.	Proline	208-215	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	147-151
33318173-5	2020	Further, we identify the ABL2 tyrosine kinase as an upstream regulator of HSF1 protein expression and show that the Src-homology 3 (SH3) domain of ABL2 directly interacts with HSF1 protein at a noncanonical, proline-independent SH3 interaction motif.	Proline	208-215	heat shock transcription factor 1	Homo sapiens	176-180
33109600-0	2020	In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1.	Proline	27-34	pyrroline-5-carboxylate reductase 1	Homo sapiens	81-86
33447346-3	2020	Phosphorylation of the proline-rich region, by kinases such as Erk2, has been suggested as an upstream activator.	Proline	23-30	mitogen-activated protein kinase 1	Homo sapiens	63-67
33379337-1	2020	Translation elongation factor eIF5A binds to ribosomes to promote peptide bonds between problematic amino acids for the reaction like prolines.	Proline	134-142	eukaryotic translation initiation factor 5A	Mus musculus	30-35
33109600-0	2020	In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1.	Proline	60-67	pyrroline-5-carboxylate reductase 1	Homo sapiens	81-86
33109600-1	2020	Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Delta1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H.	Proline	92-99	pyrroline-5-carboxylate reductase 1	Homo sapiens	124-148
33109600-1	2020	Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Delta1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H.	Proline	92-99	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-35
33109600-1	2020	Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Delta1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H.	Proline	158-165	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-35
33109600-1	2020	Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Delta1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H.	Proline	92-99	pyrroline-5-carboxylate reductase 1	Homo sapiens	37-42
33109600-1	2020	Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Delta1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H.	Proline	158-165	pyrroline-5-carboxylate reductase 1	Homo sapiens	37-42
33109600-1	2020	Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Delta1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H.	Proline	158-165	pyrroline-5-carboxylate reductase 1	Homo sapiens	124-148
33137310-8	2020	Our findings support the hypothesis that the TRAP-dependence is in part determined by the content of glycine and proline residues mainly within the signal sequence.	Proline	113-120	TRAP	Homo sapiens	45-49
33109600-2	2020	Many cancers alter their proline metabolism by upregulating the proline cycle and proline biosynthesis, and knockdowns of PYCR1 lead to decreased cell proliferation.	Proline	25-32	pyrroline-5-carboxylate reductase 1	Homo sapiens	122-127
33109600-10	2020	NFLP was also shown to phenocopy the PYCR1knockdown in MCF10A H-RASV12 breast cancer cells by inhibiting de novo proline biosynthesis and impairing spheroidal growth.	Proline	113-120	pyrroline-5-carboxylate reductase 1	Homo sapiens	37-42
33109600-11	2020	In summary, we generated the first validated chemical probe of PYCR1 and demonstrated proof-of-concept for screening proline analogs to discover inhibitors of the proline cycle.	Proline	117-124	pyrroline-5-carboxylate reductase 1	Homo sapiens	63-68
33109600-11	2020	In summary, we generated the first validated chemical probe of PYCR1 and demonstrated proof-of-concept for screening proline analogs to discover inhibitors of the proline cycle.	Proline	163-170	pyrroline-5-carboxylate reductase 1	Homo sapiens	63-68
33339191-3	2020	Under salinity stress, different treatment of AsA, Pro, or/and GSH improved growth characteristics, stomatal conductance (gs), enhanced the activities of glutathione reductase (GR), superoxide dismutase (SOD), ascorbate peroxidase (APX), and catalase (CAT) as well as increased contents of AsA, Pro, and GSH.	Proline	51-54	superoxide dismutase [Mn], mitochondrial	Cucumis sativus	182-202
33339191-3	2020	Under salinity stress, different treatment of AsA, Pro, or/and GSH improved growth characteristics, stomatal conductance (gs), enhanced the activities of glutathione reductase (GR), superoxide dismutase (SOD), ascorbate peroxidase (APX), and catalase (CAT) as well as increased contents of AsA, Pro, and GSH.	Proline	51-54	superoxide dismutase [Mn], mitochondrial	Cucumis sativus	204-207
33339191-3	2020	Under salinity stress, different treatment of AsA, Pro, or/and GSH improved growth characteristics, stomatal conductance (gs), enhanced the activities of glutathione reductase (GR), superoxide dismutase (SOD), ascorbate peroxidase (APX), and catalase (CAT) as well as increased contents of AsA, Pro, and GSH.	Proline	51-54	peroxidase 2-like	Cucumis sativus	220-230
33339191-3	2020	Under salinity stress, different treatment of AsA, Pro, or/and GSH improved growth characteristics, stomatal conductance (gs), enhanced the activities of glutathione reductase (GR), superoxide dismutase (SOD), ascorbate peroxidase (APX), and catalase (CAT) as well as increased contents of AsA, Pro, and GSH.	Proline	51-54	catalase isozyme 1	Cucumis sativus	242-250
33339191-3	2020	Under salinity stress, different treatment of AsA, Pro, or/and GSH improved growth characteristics, stomatal conductance (gs), enhanced the activities of glutathione reductase (GR), superoxide dismutase (SOD), ascorbate peroxidase (APX), and catalase (CAT) as well as increased contents of AsA, Pro, and GSH.	Proline	51-54	catalase isozyme 1	Cucumis sativus	252-255
33381127-10	2020	Compared with the wild-type seedlings, PCD-suppression in lht1and aap1 mutants was significantly reduced when supplied with low proline (1-5 muM) levels.	Proline	128-135	amino acid permease 1	Arabidopsis thaliana	66-70
33023907-0	2020	The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation.	Proline	63-70	MLX interacting protein-like	Mus musculus	41-47
33023907-4	2020	Here we report that ChREBP is modified by proline hydroxylation at several residues.	Proline	42-49	MLX interacting protein-like	Mus musculus	20-26
33023907-5	2020	Proline hydroxylation targets both ectopically expressed ChREBP in cells and endogenous ChREBP in mouse liver.	Proline	0-7	MLX interacting protein-like	Mus musculus	57-63
33023907-5	2020	Proline hydroxylation targets both ectopically expressed ChREBP in cells and endogenous ChREBP in mouse liver.	Proline	0-7	MLX interacting protein-like	Mus musculus	88-94
33023907-6	2020	Functionally, we found that specific hydroxylated prolines were dispensable for protein stability but required for the adequate activation of ChREBP upon exposure to high glucose.	Proline	50-58	MLX interacting protein-like	Mus musculus	142-148
33023907-7	2020	Accordingly, ChREBP target gene expression was rescued by re-expressing wild-type but not ChREBP that lacks hydroxylated prolines in ChREBP-deleted hepatocytes.	Proline	121-129	MLX interacting protein-like	Mus musculus	13-19
33023907-8	2020	Thus, proline hydroxylation of ChREBP is a novel post-translational modification that may allow for therapeutic interference in metabolic diseases.	Proline	6-13	MLX interacting protein-like	Mus musculus	31-37
33188775-5	2020	To summarize, features in the Tau protein critical for disease intervention at different stages of disease are identified, including enrichment of 0N and 4R isoforms, underrepresentation of the C terminus, an increase in negative charge in the proline-rich region (PRR), and a decrease in positive charge in the microtubule binding domain (MBD).	Proline	244-251	microtubule associated protein tau	Homo sapiens	30-33
33226806-4	2020	Three novel 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-conjugated CCK2R ligands with proline substitution at different positions were synthesized.	Proline	106-113	cholecystokinin B receptor	Mus musculus	87-92
33226806-7	2020	The inclusion of Pro contributes significantly to the development of CCK2R ligands with optimal targeting properties for application in targeted radiotherapy.	Proline	17-20	cholecystokinin B receptor	Mus musculus	69-74
33303781-5	2020	The cleavage occurs between Pro-355 and Val-356, which is the same cleavage site that the metalloprotease ADAM17 uses in vitro.	Proline	28-31	a disintegrin and metallopeptidase domain 17	Mus musculus	106-112
33280590-10	2022	RESULTS: Eight amino acid levels (methionine, arginine, cystine, glutamine, proline, asparagine, serine, aspartate) were significantly altered in patients with neurofibromatosis type 1.	Proline	76-83	neurofibromin 1	Homo sapiens	160-184
33424902-4	2020	The difficulty to isolate ProDH in active form has led several researchers to erroneously report proline-dependent NAD+ reduction at pH 10 as ProDH activity.	Proline	97-104	proline dehydrogenase 1	Homo sapiens	26-31
33424902-4	2020	The difficulty to isolate ProDH in active form has led several researchers to erroneously report proline-dependent NAD+ reduction at pH 10 as ProDH activity.	Proline	97-104	proline dehydrogenase 1	Homo sapiens	142-147
33424902-5	2020	We demonstrate that this activity is due to P5C reductase (P5CR), the second and last enzyme in proline biosynthesis, which works in the reverse direction at unphysiologically high pH.	Proline	96-103	pyrroline-5-carboxylate reductase 1	Homo sapiens	44-57
33424902-5	2020	We demonstrate that this activity is due to P5C reductase (P5CR), the second and last enzyme in proline biosynthesis, which works in the reverse direction at unphysiologically high pH.	Proline	96-103	pyrroline-5-carboxylate reductase 1	Homo sapiens	59-63
33347465-5	2020	Utilizing whole exome sequencing analysis, we identified a novel CERT variant, which substitutes a serine at position 135 (S135) for a proline in a patient with severe ID.	Proline	135-142	ceramide transporter 1	Homo sapiens	65-69
33554046-0	2020	Mitochondrial dynamics links PINCH-1 signaling to proline metabolic reprogramming and tumor growth.	Proline	50-57	LIM zinc finger domain containing 1	Homo sapiens	29-36
33554046-9	2020	In a recent study (Guo et al., Nat Commun 11(1):4913, doi: 10.1038/s41467-020-18753-6), we have identified PINCH-1, a component of cell-extracellular matrix (ECM) adhesions, as an important regulator of proline synthesis and cancer progression.	Proline	203-210	LIM zinc finger domain containing 1	Homo sapiens	107-114
32978259-6	2020	NAA80 binds PFN2 through a proline-rich loop, deletion of which abrogates PFN2 binding.	Proline	27-34	N-alpha-acetyltransferase 80, NatH catalytic subunit	Homo sapiens	0-5
32978259-6	2020	NAA80 binds PFN2 through a proline-rich loop, deletion of which abrogates PFN2 binding.	Proline	27-34	profilin 2	Homo sapiens	12-16
32978259-7	2020	Small-angle X-ray scattering shows that NAA80, actin and PFN2 form a ternary complex and that NAA80 has partly disordered regions in the N-terminus and the proline-rich loop, the latter of which is partly ordered upon PFN2 binding.	Proline	156-163	N-alpha-acetyltransferase 80, NatH catalytic subunit	Homo sapiens	94-99
32978259-8	2020	Furthermore, binding of PFN2 to NAA80 via the proline-rich loop promotes binding between the globular domains of actin and NAA80, and thus acetylation of actin.	Proline	46-53	profilin 2	Homo sapiens	24-28
32978259-8	2020	Furthermore, binding of PFN2 to NAA80 via the proline-rich loop promotes binding between the globular domains of actin and NAA80, and thus acetylation of actin.	Proline	46-53	N-alpha-acetyltransferase 80, NatH catalytic subunit	Homo sapiens	32-37
32978259-8	2020	Furthermore, binding of PFN2 to NAA80 via the proline-rich loop promotes binding between the globular domains of actin and NAA80, and thus acetylation of actin.	Proline	46-53	N-alpha-acetyltransferase 80, NatH catalytic subunit	Homo sapiens	123-128
33273615-3	2020	The proline-rich region of tau remains poorly defined in the context of tau amyloid structures, despite the clustering of several phosphorylation sites, which have been associated with Alzheimer"s disease.	Proline	4-11	microtubule associated protein tau	Homo sapiens	27-30
33287453-9	2020	Proline concentration and collagen biosynthesis were increased in HaCaT cells under prolidase treatment.	Proline	0-7	peptidase D	Homo sapiens	84-93
33273615-4	2020	In order to gain insight into the contribution of the proline-rich region P2 of tau to amyloid fibrils, we studied in vitro aggregated amyloid fibrils of tau constructs, which contain both the proline-rich region P2 and the pseudo-repeats.	Proline	54-61	microtubule associated protein tau	Homo sapiens	80-83
33364460-1	2020	l-proline (Pro) is a precursor of ornithine, which is converted into polyamines via ornithine decarboxylase (ODC).	Proline	0-9	ornithine decarboxylase 1	Sus scrofa	84-107
33276680-3	2020	One of the coordinators in this pathway is Nemo-like kinase (NLK), which is an atypical proline-directed serine/threonine mitogen-activated protein (MAP) kinase.	Proline	88-95	nemo like kinase	Mus musculus	43-59
33276680-3	2020	One of the coordinators in this pathway is Nemo-like kinase (NLK), which is an atypical proline-directed serine/threonine mitogen-activated protein (MAP) kinase.	Proline	88-95	nemo like kinase	Mus musculus	61-64
33364460-1	2020	l-proline (Pro) is a precursor of ornithine, which is converted into polyamines via ornithine decarboxylase (ODC).	Proline	0-9	ornithine decarboxylase 1	Sus scrofa	109-112
33364460-1	2020	l-proline (Pro) is a precursor of ornithine, which is converted into polyamines via ornithine decarboxylase (ODC).	Proline	11-14	ornithine decarboxylase 1	Sus scrofa	84-107
33364460-1	2020	l-proline (Pro) is a precursor of ornithine, which is converted into polyamines via ornithine decarboxylase (ODC).	Proline	11-14	ornithine decarboxylase 1	Sus scrofa	109-112
33364460-7	2020	Supplementing Pro to either gilts or IPEC-J2 cells increased ODC protein abundances and polyamine concentrations in the fetal intestines and IPEC-J2 cells (P < 0.05).	Proline	14-17	ornithine decarboxylase 1	Sus scrofa	61-64
33364460-8	2020	In comparison with the Pro group, the combined administration of Pro and DFMO reduced the expression of ODC protein and spermine concentration in the fetal intestine, as well as the concentrations of putrescine, spermidine and spermine in IPEC-J2 cells (P < 0.05).	Proline	65-68	ornithine decarboxylase 1	Sus scrofa	104-107
32810603-2	2020	APOA1 is a 28 kDa protein comprising multiple lipid-binding amphiphatic helices initialized by proline residues, which are conserved across multiple species.	Proline	95-102	apolipoprotein A1	Homo sapiens	0-5
32810603-5	2020	RESULTS: Differences in microsolubilization were profound and showed that conserved prolines, especially those in the C-terminus of APOA1, are essential to efficient rHDL formation.	Proline	84-92	apolipoprotein A1	Homo sapiens	132-137
32810603-8	2020	CONCLUSION: Studies of DMPC microsolubilization show that proline residues are essential to the optimal interaction of APOA1 with membranes, the initial step in cholesterol efflux and HDL production.	Proline	58-65	apolipoprotein A-I	Mus musculus	119-124
32818927-2	2020	Herein, molecular dynamics simulations were performed to investigate the effect of MoS2 nanotube on the binding of the signal protein YAP65, an important Yes kinase-associated protein domain (WW domain), to the proline rich motif ligand (PRM).	Proline	211-218	Yes1 associated transcriptional regulator	Homo sapiens	134-139
32979494-0	2020	The membrane proximal proline-rich region and correct order of C-terminal tyrosines on the adaptor protein LAT are required for TCR-mediated signaling and downstream functions.	Proline	22-29	linker for activation of T cells	Homo sapiens	107-110
32979494-7	2020	Using LAT mutants expressed in Jurkat E6.1 cells, we observed that the membrane proximal, proline-rich region of LAT and the correct order of domains containing conserved tyrosines are necessary for optimal TCR-mediated early signaling, cytokine production, and cellular adhesion.	Proline	90-97	linker for activation of T cells	Homo sapiens	113-116
33247146-4	2020	Catalysis of proline isomerization by cyclophilin A lowers the energy barrier for alpha-synuclein misfolding, while isomerase-binding to a separate, disease-associated protein region opposes aggregation.	Proline	13-20	synuclein alpha	Homo sapiens	82-97
32603918-6	2020	Myosin light chain (MYL1 and MYL3) showed high oxidative susceptibility owing to peptidyl methionine and proline oxidation as well as acetaldehyde adduct formation on lysine or histidine residues.	Proline	105-112	myosin light chain 1	Homo sapiens	20-24
32603918-6	2020	Myosin light chain (MYL1 and MYL3) showed high oxidative susceptibility owing to peptidyl methionine and proline oxidation as well as acetaldehyde adduct formation on lysine or histidine residues.	Proline	105-112	myosin light chain 3	Homo sapiens	29-33
32920905-3	2020	Here, we have characterised a proline-cleaving aminopeptidase in Arabidopsis thaliana, prolyl aminopeptidase-2 (PAP2, At3g61540).	Proline	30-37	aminopeptidase	Arabidopsis thaliana	47-61
33393253-8	2020	The proline contents in sunflower decreased significantly in different treatments, while the proline content of corn was significantly higher than that of control at 0.05 g mL-1.	Proline	93-100	L1 cell adhesion molecule	Mus musculus	173-177
33343574-3	2020	Here, we introduced an inducible leucine to proline point mutation into the mouse Myd88 locus, at the orthologous position L252P.	Proline	44-51	myeloid differentiation primary response gene 88	Mus musculus	82-87
33352067-7	2020	We propose that the EVH1 domain of PP4 represents a new class of the EVH1 family that can accommodate low proline content sequences, such as the FxxP motif.	Proline	106-113	Protein phosphatase 4 regulatory subunit 2-related protein	Drosophila melanogaster	35-38
32963106-6	2020	Conserved proline residues within the LAP/LAP-like motifs of these two proteins are hydroxylated by the prolyl hydroxylase enzymes (PHD2/EGLN1 and PHD3/EGLN3), which is prerequisite for pVHL-mediated degradation.	Proline	10-17	egl-9 family hypoxia-inducible factor 1b	Danio rerio	137-142
32963106-6	2020	Conserved proline residues within the LAP/LAP-like motifs of these two proteins are hydroxylated by the prolyl hydroxylase enzymes (PHD2/EGLN1 and PHD3/EGLN3), which is prerequisite for pVHL-mediated degradation.	Proline	10-17	egl-9 family hypoxia-inducible factor 3	Danio rerio	147-151
32963106-6	2020	Conserved proline residues within the LAP/LAP-like motifs of these two proteins are hydroxylated by the prolyl hydroxylase enzymes (PHD2/EGLN1 and PHD3/EGLN3), which is prerequisite for pVHL-mediated degradation.	Proline	10-17	egl-9 family hypoxia-inducible factor 3	Danio rerio	152-157
33051185-2	2020	ProXp-ala prevents proteome-wide Pro-to-Ala mutations by hydrolyzing misacylated Ala-tRNAPro, which is synthesized by prolyl-tRNA synthetase (ProRS).	Proline	0-3	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	118-140
33051185-2	2020	ProXp-ala prevents proteome-wide Pro-to-Ala mutations by hydrolyzing misacylated Ala-tRNAPro, which is synthesized by prolyl-tRNA synthetase (ProRS).	Proline	0-3	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	142-147
33247146-6	2020	Removal of the proline isomerization barrier through posttranslational truncation of alpha-synuclein reverses the action of the proline isomerase and turns it into a potent molecular chaperone that inhibits protein misfolding.	Proline	15-22	synuclein alpha	Homo sapiens	85-100
33247146-6	2020	Removal of the proline isomerization barrier through posttranslational truncation of alpha-synuclein reverses the action of the proline isomerase and turns it into a potent molecular chaperone that inhibits protein misfolding.	Proline	128-135	synuclein alpha	Homo sapiens	85-100
33294127-4	2020	Proline dehydrogenase (PRODH) is located on the inner mitochondrial membrane and is an enzyme that catalyzes the first step of proline catabolism, which plays an important role in improving the cellular redox state.	Proline	127-134	proline dehydrogenase 1	Homo sapiens	0-21
33294127-9	2020	Enhanced proline metabolism induced by PRODH overexpression reduced the levels of reactive oxidative stress and apoptosis, whereas PRODH knockdown had the opposite effects.	Proline	9-16	proline dehydrogenase 1	Homo sapiens	39-44
33294127-4	2020	Proline dehydrogenase (PRODH) is located on the inner mitochondrial membrane and is an enzyme that catalyzes the first step of proline catabolism, which plays an important role in improving the cellular redox state.	Proline	127-134	proline dehydrogenase 1	Homo sapiens	23-28
33294127-6	2020	This study is aimed at investigating whether enhancing proline metabolism by overexpressing PRODH can ameliorate hypoxia-induced injury in cardiomyocytes and to reveal the related altered metabolites and mechanistic pathway via untargeted metabolomics analysis.	Proline	55-62	proline dehydrogenase 1	Homo sapiens	92-97
33294127-7	2020	Methods and Results: First, through public database analysis and RT-qPCR and western blot analyses in a cardiomyocyte hypoxia model, we found that the expression of the proline-degrading enzyme PRODH was downregulated after myocardial infarction and hypoxia exposure.	Proline	169-176	proline dehydrogenase 1	Homo sapiens	194-199
32516727-10	2020	Also, increased total soluble carbohydrates, cysteine, and Pro accumulation with increased Pro synthesizing enzyme (Delta1-pyrroline-5-carboxylate synthetase (P5CS) and decreased Pro degrading enzyme (proline dehydrogenase) in Mel + Ca2+ treated plants conferred As toxicity tolerance.	Proline	59-62	aldehyde dehydrogenase 18 family member A1	Homo sapiens	122-157
33096080-0	2020	Structural Model of the Proline-rich Domain of Huntingtin exon-1 fibrils.	Proline	24-31	huntingtin	Homo sapiens	47-57
33168105-5	2020	R533* mutation impairs CTTNBP2 interaction with cortactin due to lack of the C-terminal proline-rich domain.	Proline	88-95	cortactin binding protein 2	Mus musculus	23-30
33168105-5	2020	R533* mutation impairs CTTNBP2 interaction with cortactin due to lack of the C-terminal proline-rich domain.	Proline	88-95	cortactin	Mus musculus	48-57
33224159-5	2020	In addition, the transgenic plants also show enhanced ROS scavenging activity, reduced ion leakage under salt stress, smaller stomatal opening, and more proline and soluble sugar accumulation, which demonstrate that UGT76C2 acts as an important player in abiotic stress response in rice.	Proline	153-160	UDP-glucosyl transferase 76C2	Arabidopsis thaliana	216-223
33208151-9	2020	In the striatum, non-eCB lipids were significantly increased by short-term, escalating morphine exposure, including peroxisome proliferator activator receptor alpha (PPAR-alpha) ligands N-oleoyl ethanolamide (OEA) and N-palmitoyl ethanolamide (PEA), as well as the amino acids phenylalanine and proline.	Proline	295-302	peroxisome proliferator activated receptor alpha	Homo sapiens	166-176
33171852-5	2020	The main feature of ACE inhibitory peptides is the location of the hydrophobic residue, usually Proline, at the C-terminus.	Proline	96-103	angiotensin I converting enzyme	Homo sapiens	20-23
33151107-6	2020	The SNP was located in exon 4 (XM_018050765.1) of the AMH gene and was one nonsynonymous substitution, which resulted in a change of an amino acid from Glutamine to Proline (Gln38Pro).	Proline	165-172	muellerian-inhibiting factor	Capra hircus	54-57
32470312-6	2020	Pro-inflammatory-like macrophages (CD11b+,CD206-) increased (p<0.05) with NMES+PRO treatment and was different than CON.	Proline	79-82	integrin subunit alpha M	Homo sapiens	35-40
33294784-3	2020	Proline insertions in the TNFalpha transmembrane (TM) helix strongly increased SPPL2a non-canonical shedding, while leucine mutations decreased this cleavage.	Proline	0-7	tumor necrosis factor	Homo sapiens	26-34
33294784-3	2020	Proline insertions in the TNFalpha transmembrane (TM) helix strongly increased SPPL2a non-canonical shedding, while leucine mutations decreased this cleavage.	Proline	0-7	signal peptide peptidase like 2A	Homo sapiens	79-85
33148293-6	2020	RESULTS: DMR7 and SKT82 bind epitopes comprised of the proline-rich domain and c-terminal region of tau and binding is reduced upon disruption of the pathological conformation of AD-tau by chemical and thermal denaturation.	Proline	55-62	microtubule associated protein tau	Homo sapiens	100-103
33148293-6	2020	RESULTS: DMR7 and SKT82 bind epitopes comprised of the proline-rich domain and c-terminal region of tau and binding is reduced upon disruption of the pathological conformation of AD-tau by chemical and thermal denaturation.	Proline	55-62	microtubule associated protein tau	Homo sapiens	182-185
32997736-0	2020	The proline-rich domain promotes Tau liquid-liquid phase separation in cells.	Proline	4-11	microtubule associated protein tau	Homo sapiens	33-36
33017192-2	2020	We have previously shown that expression of small proline-rich region 2f (Sprr2f), a member of the small proline-rich region (Sprr) gene family, is increased several hundredfold after renal injury using a unilateral ureteral obstruction (UUO) mouse model.	Proline	50-57	small proline-rich protein 2F	Mus musculus	74-80
32398684-1	2020	Dipeptidyl peptidase 4 (DPP4), a ubiquitously expressed protease that cleaves off the N-terminal dipeptide from proline and alanine on the penultimate position, has important roles in many physiological processes.	Proline	112-119	dipeptidylpeptidase 4	Mus musculus	0-22
32398684-1	2020	Dipeptidyl peptidase 4 (DPP4), a ubiquitously expressed protease that cleaves off the N-terminal dipeptide from proline and alanine on the penultimate position, has important roles in many physiological processes.	Proline	112-119	dipeptidylpeptidase 4	Mus musculus	24-28
32470312-6	2020	Pro-inflammatory-like macrophages (CD11b+,CD206-) increased (p<0.05) with NMES+PRO treatment and was different than CON.	Proline	79-82	mannose receptor C-type 1	Homo sapiens	42-47
33044914-1	2020	Prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), is an enzyme that cleaves short peptides (<30 amino acids in length) on the C-terminal side of proline.	Proline	167-174	prolyl endopeptidase	Mus musculus	0-20
33044914-1	2020	Prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), is an enzyme that cleaves short peptides (<30 amino acids in length) on the C-terminal side of proline.	Proline	167-174	prolyl endopeptidase	Mus musculus	22-26
33044914-1	2020	Prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), is an enzyme that cleaves short peptides (<30 amino acids in length) on the C-terminal side of proline.	Proline	167-174	prolyl endopeptidase	Mus musculus	43-64
33044914-1	2020	Prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), is an enzyme that cleaves short peptides (<30 amino acids in length) on the C-terminal side of proline.	Proline	167-174	prolyl endopeptidase	Mus musculus	66-69
32990380-7	2020	RESULTS: In the majority of mESCs, KLF3 protein is actively degraded due to its proline-rich sequence and highly disordered structure.	Proline	80-87	Kruppel-like factor 3 (basic)	Mus musculus	35-39
32720054-8	2020	It was speculated that proline was, to some extent, involved in improving the loss of protein folding or function resulting from HSP70 deficiency, and played a crucial role in the adaptation of plants on exposure to stress.	Proline	23-30	heat shock protein 70	Solanum lycopersicum	129-134
32856412-1	2020	HLA-B*15:01:39 has one synonymous nucleotide change from HLA-B*15:01:01:01 at nucleotide 117 (residue 15 Proline).	Proline	105-112	major histocompatibility complex, class I, B	Homo sapiens	0-5
32707041-6	2020	PRMT5 knockdown increased the levels of amino acids and carbohydrates, particularly related to the arginine metabolism such as glutamate, glutamine (Gln), proline, creatine, creatinine and phosphocreatine (PCr).	Proline	155-162	protein arginine methyltransferase 5	Homo sapiens	0-5
32856412-1	2020	HLA-B*15:01:39 has one synonymous nucleotide change from HLA-B*15:01:01:01 at nucleotide 117 (residue 15 Proline).	Proline	105-112	major histocompatibility complex, class I, B	Homo sapiens	57-62
32905906-7	2020	A direct interaction between the proline-rich domain of FasL and the SH3 domain of PI(3)K-p85alpha initiates the first pathway.	Proline	33-40	Fas ligand	Homo sapiens	56-60
32901865-3	2020	Proline rich polypeptide 1 (PRP-1), which is a 15-amino acid inhibitor of mammalian target of rapamycin complex-1 (mTORC1), has been indicated to exert cytostatic and immunomodulatory properties in human chondrosarcoma cells in a monolayer.	Proline	0-7	CREB regulated transcription coactivator 1	Mus musculus	115-121
32905906-7	2020	A direct interaction between the proline-rich domain of FasL and the SH3 domain of PI(3)K-p85alpha initiates the first pathway.	Proline	33-40	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	90-98
32905906-10	2020	FasL can recruit Fyn via the proline-rich domain leading to the recruitment of ADAP.	Proline	29-36	Fas ligand	Homo sapiens	0-4
32905906-10	2020	FasL can recruit Fyn via the proline-rich domain leading to the recruitment of ADAP.	Proline	29-36	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	17-20
32905906-10	2020	FasL can recruit Fyn via the proline-rich domain leading to the recruitment of ADAP.	Proline	29-36	FYN binding protein 1	Homo sapiens	79-83
33867340-11	2020	Tail vein injection of Ad-Smad7 decreased both hydroxyl proline and collagen volume fraction.	Proline	56-63	SMAD family member 7	Rattus norvegicus	26-31
32907884-0	2020	Processing and formation of bioactive CLE40 peptide are controlled by post-translational proline hydroxylation.	Proline	89-96	CLAVATA3/ESR-RELATED 40	Arabidopsis thaliana	38-43
32907884-7	2020	The second cleavage is prevented by proline hydroxylation resulting in the formation of mature and bioactive CLE40 in planta.	Proline	36-43	CLAVATA3/ESR-RELATED 40	Arabidopsis thaliana	109-114
32907884-8	2020	Our data reveal a role for post-translational modification by proline hydroxylation in the regulation of CLE40 formation and activity.	Proline	62-69	CLAVATA3/ESR-RELATED 40	Arabidopsis thaliana	105-110
33122699-5	2020	Interestingly, it was found that TNPO2 does not mediate nuclear export, but rather is involved in the cytoplasmic retention of ERalpha via the proline/tyrosine (PY) motifs.	Proline	143-150	transportin 2	Homo sapiens	33-38
33127913-4	2020	Mechanistically, the proline-rich motif-mediated interaction of PRR11 with the p85alpha regulatory subunit of PI3K suppresses p85 homodimerization, thus enhancing insulin-stimulated binding of p110-p85alpha heterodimers to IRS1 and activation of PI3K.	Proline	21-28	proline rich 11	Homo sapiens	64-69
33127913-4	2020	Mechanistically, the proline-rich motif-mediated interaction of PRR11 with the p85alpha regulatory subunit of PI3K suppresses p85 homodimerization, thus enhancing insulin-stimulated binding of p110-p85alpha heterodimers to IRS1 and activation of PI3K.	Proline	21-28	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	79-87
33127913-4	2020	Mechanistically, the proline-rich motif-mediated interaction of PRR11 with the p85alpha regulatory subunit of PI3K suppresses p85 homodimerization, thus enhancing insulin-stimulated binding of p110-p85alpha heterodimers to IRS1 and activation of PI3K.	Proline	21-28	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	79-82
33127913-4	2020	Mechanistically, the proline-rich motif-mediated interaction of PRR11 with the p85alpha regulatory subunit of PI3K suppresses p85 homodimerization, thus enhancing insulin-stimulated binding of p110-p85alpha heterodimers to IRS1 and activation of PI3K.	Proline	21-28	insulin receptor substrate 1	Homo sapiens	223-227
32783538-0	2020	Hb broomhill [alpha1 or alpha2 114(GH2) pro > ala;HBA1 or HBA2:c.343C > G]: a rare Hb variant found in a diabetic chinese individual.	Proline	40-43	growth hormone 2	Homo sapiens	35-38
32783538-1	2020	We report a clinically silent hemoglobin (Hb) variant, Hb Broomhill [alpha1 or alpha2 114(GH2) Pro > Ala;HBA1 or HBA2:c.343C > G] in a diabetic Chinese man.	Proline	95-98	growth hormone 2	Homo sapiens	90-93
33122699-5	2020	Interestingly, it was found that TNPO2 does not mediate nuclear export, but rather is involved in the cytoplasmic retention of ERalpha via the proline/tyrosine (PY) motifs.	Proline	143-150	estrogen receptor 1	Homo sapiens	127-134
32800549-3	2020	Our previous study showed that arginine inhibits proline utilization by specifically inducing the endocytosis of the high-affinity proline transporter Put4.	Proline	49-56	proline permease PUT4	Saccharomyces cerevisiae S288C	151-155
32800549-3	2020	Our previous study showed that arginine inhibits proline utilization by specifically inducing the endocytosis of the high-affinity proline transporter Put4.	Proline	131-138	proline permease PUT4	Saccharomyces cerevisiae S288C	151-155
32800549-9	2020	More importantly, we discovered that deletion of ART3 remarkably canceled the inhibitory effects of arginine on proline utilization.	Proline	112-119	Aly2p	Saccharomyces cerevisiae S288C	49-53
32979304-9	2020	Thus, phosphorylation of pro-Casp8 at Thr265 by RSK is an intrinsic mechanism for passing the Casp8 checkpoint of necroptosis.	Proline	25-28	caspase 8	Mus musculus	29-34
33092263-4	2020	The proline adduct was the most active compound, it showed anti-leukemic activity, upregulated heme oxygenase 1 (HMOX1) and the primary stress-inducible isoform of the heath shock 70 kDa protein 1 (HSPA1A), and downregulated NFkB1 transcription, it was also found to be about 270 times more water soluble than dehydroleucodine.	Proline	4-11	heme oxygenase 1	Homo sapiens	95-111
33092263-4	2020	The proline adduct was the most active compound, it showed anti-leukemic activity, upregulated heme oxygenase 1 (HMOX1) and the primary stress-inducible isoform of the heath shock 70 kDa protein 1 (HSPA1A), and downregulated NFkB1 transcription, it was also found to be about 270 times more water soluble than dehydroleucodine.	Proline	4-11	heme oxygenase 1	Homo sapiens	113-118
33092263-4	2020	The proline adduct was the most active compound, it showed anti-leukemic activity, upregulated heme oxygenase 1 (HMOX1) and the primary stress-inducible isoform of the heath shock 70 kDa protein 1 (HSPA1A), and downregulated NFkB1 transcription, it was also found to be about 270 times more water soluble than dehydroleucodine.	Proline	4-11	heat shock protein family A (Hsp70) member 1A	Homo sapiens	198-204
33092263-4	2020	The proline adduct was the most active compound, it showed anti-leukemic activity, upregulated heme oxygenase 1 (HMOX1) and the primary stress-inducible isoform of the heath shock 70 kDa protein 1 (HSPA1A), and downregulated NFkB1 transcription, it was also found to be about 270 times more water soluble than dehydroleucodine.	Proline	4-11	nuclear factor kappa B subunit 1	Homo sapiens	225-230
32979304-9	2020	Thus, phosphorylation of pro-Casp8 at Thr265 by RSK is an intrinsic mechanism for passing the Casp8 checkpoint of necroptosis.	Proline	25-28	ribosomal protein S6 kinase polypeptide 1	Mus musculus	48-51
32979304-9	2020	Thus, phosphorylation of pro-Casp8 at Thr265 by RSK is an intrinsic mechanism for passing the Casp8 checkpoint of necroptosis.	Proline	25-28	caspase 8	Mus musculus	94-99
33110983-5	2020	The first AD target that we have addressed with this method is the serine-threonine kinase glycogen synthase kinase 3 beta (GSK3beta), which is a proline-directed serine-threonine kinase that phosphorylates the microtubule-stabilizing protein tau.	Proline	146-153	glycogen synthase kinase 3 beta	Homo sapiens	91-122
33083024-2	2020	Pyrroline-5-carboxylate reductase (PYCR) and proline dehydrogenase (PRODH) enzymes, which catalyze the last step in proline biosynthesis and the first step of its catabolism, respectively, have been extensively associated with the progression of several malignancies, and have been exposed as potential targets for anticancer drug development.	Proline	45-52	proline dehydrogenase 1	Homo sapiens	68-73
33083024-2	2020	Pyrroline-5-carboxylate reductase (PYCR) and proline dehydrogenase (PRODH) enzymes, which catalyze the last step in proline biosynthesis and the first step of its catabolism, respectively, have been extensively associated with the progression of several malignancies, and have been exposed as potential targets for anticancer drug development.	Proline	45-52	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-33
33083024-2	2020	Pyrroline-5-carboxylate reductase (PYCR) and proline dehydrogenase (PRODH) enzymes, which catalyze the last step in proline biosynthesis and the first step of its catabolism, respectively, have been extensively associated with the progression of several malignancies, and have been exposed as potential targets for anticancer drug development.	Proline	45-52	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-39
33110983-5	2020	The first AD target that we have addressed with this method is the serine-threonine kinase glycogen synthase kinase 3 beta (GSK3beta), which is a proline-directed serine-threonine kinase that phosphorylates the microtubule-stabilizing protein tau.	Proline	146-153	glycogen synthase kinase 3 alpha	Homo sapiens	124-132
33110983-5	2020	The first AD target that we have addressed with this method is the serine-threonine kinase glycogen synthase kinase 3 beta (GSK3beta), which is a proline-directed serine-threonine kinase that phosphorylates the microtubule-stabilizing protein tau.	Proline	146-153	microtubule associated protein tau	Homo sapiens	243-246
33842008-0	2021	A proline-rich motif in the large intracellular loop of the glycine receptor alpha1 subunit interacts with the Pleckstrin homology domain of collybistin.	Proline	2-9	Cdc42 guanine nucleotide exchange factor 9	Homo sapiens	141-152
33036565-8	2020	Among them, SlGAD1 expression was the most sensitive and contributed the most to the increase in glutamate decarboxylase (GAD) activity induced by NaCl and GABA application; Exogenous GABA increased GAD activity and amino acid contents in tomato leaves compared with the levels under NaCl stress alone, especially the levels of endogenous GABA, proline, glutamate and eight other amino acids.	Proline	345-352	glutamate decarboxylase	Solanum lycopersicum	97-120
33036565-8	2020	Among them, SlGAD1 expression was the most sensitive and contributed the most to the increase in glutamate decarboxylase (GAD) activity induced by NaCl and GABA application; Exogenous GABA increased GAD activity and amino acid contents in tomato leaves compared with the levels under NaCl stress alone, especially the levels of endogenous GABA, proline, glutamate and eight other amino acids.	Proline	345-352	glutamate decarboxylase	Solanum lycopersicum	14-17
33036565-8	2020	Among them, SlGAD1 expression was the most sensitive and contributed the most to the increase in glutamate decarboxylase (GAD) activity induced by NaCl and GABA application; Exogenous GABA increased GAD activity and amino acid contents in tomato leaves compared with the levels under NaCl stress alone, especially the levels of endogenous GABA, proline, glutamate and eight other amino acids.	Proline	345-352	glutamate decarboxylase	Solanum lycopersicum	122-125
33842008-9	2021	When the five proline residues P365A, P366A, P367A, P369A, P373A (GlyRalpha1P1-5A) located in the GlyRalpha1-PPII helix were replaced by alanines, the PPII secondary structure was disrupted.	Proline	14-21	glycine receptor alpha 1	Homo sapiens	66-76
33090265-11	2020	Furthermore, positive correlations were observed when comparing plasma DAO activity with histidine, proline, cystine, arginine, and glutamine concentrations.	Proline	100-107	D-amino acid oxidase	Bos taurus	71-74
32476470-3	2020	In a systematic genetic analysis, we identified a suppression interaction between tRNASerUGG, G26A, which mistranslates proline codons by inserting serine, and eco1-1, a temperature sensitive allele of the gene encoding an acetyltransferase required for sister chromatid cohesion.	Proline	120-127	Eco1p	Saccharomyces cerevisiae S288C	160-164
32476470-5	2020	Sequencing of the eco1-1 allele revealed a mutation that would convert the highly conserved serine 213 within beta7 of the GCN5-related N-acetyltransferase core to proline.	Proline	164-171	Eco1p	Saccharomyces cerevisiae S288C	18-22
31820037-4	2020	Peptide microarray and co-immunoprecipitation results demonstrate that CRKL binds to proline-rich regions located in C-terminal, intrinsically disordered region of BCR-ABL, that SHC1 requires pleckstrin homology, src homology and tyrosine kinase domains of BCR-ABL for binding, and that BCR-ABL sequence motif located in disordered region around phosphorylated tyrosine 177 mediates binding of three core complex members, i.e., GRB2, SOS1, and cCBL.	Proline	85-92	CRK like proto-oncogene, adaptor protein	Homo sapiens	71-75
32693110-0	2020	The proline-rich tyrosine kinase Pyk2 modulates integrin-mediated neutrophil adhesion and reactive oxygen species generation.	Proline	4-11	PTK2 protein tyrosine kinase 2 beta	Mus musculus	33-37
32690595-9	2020	A proline substitution in the alpha-helix, found in mouse LPL, is expected to interfere with several hydrogen bonds, explaining why 5D2 cannot bind to mouse LPL.	Proline	2-9	lipoprotein lipase	Mus musculus	58-61
32771261-10	2020	In conclusion, it is suggested that ATA2, at least in part, is involved in the transport of L-Pro in the retinal pericytes.	Proline	92-97	solute carrier family 38, member 2	Rattus norvegicus	36-40
32730893-1	2020	Neuropeptides belonging to the adipokinetic hormone (AKH) family elicit metabolic effects as their main function in insects, by mobilizing trehalose, diacylgycerol, or proline, which are released from the fat body into the hemolymph as energy sources for muscle contraction required for energy-intensive processes, such as locomotion.	Proline	168-175	hypertrehalosaemic prohormone	Apis mellifera	53-56
32584658-5	2020	Compared with SCT-II, higher glycine content (337.80 and 339.93 residues/1000 residues) and lower degree of proline hydroxylation (51.81% and 52.52%) were observed in ASC and PSC.	Proline	108-115	apoptosis-associated speck-like protein containing a CARD	Bos taurus	167-170
32748014-5	2020	One of them (strain K-9-AZC) carried a novel mutation in the PRO1 gene encoding the Gln79His variant of the gamma-glutamyl kinase Pro1, a key enzyme in proline biosynthesis in S. cerevisiae.	Proline	152-159	glutamate 5-kinase	Saccharomyces cerevisiae S288C	61-65
32748014-5	2020	One of them (strain K-9-AZC) carried a novel mutation in the PRO1 gene encoding the Gln79His variant of the gamma-glutamyl kinase Pro1, a key enzyme in proline biosynthesis in S. cerevisiae.	Proline	152-159	glutamate 5-kinase	Saccharomyces cerevisiae S288C	130-134
32588458-7	2020	Administration of (34 Pro,35 Phe)CGRP27-37 to mice led to a significant decrease in CGRP-induced PPE confirming antagonistic properties in vivo.	Proline	22-25	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	33-37
33004813-0	2020	PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.	Proline	52-59	LIM and senescent cell antigen-like domains 1	Mus musculus	0-7
33004813-2	2020	Here we show that PINCH-1 is highly expressed in lung adenocarcinoma and promotes proline synthesis through regulation of mitochondrial dynamics.	Proline	82-89	LIM and senescent cell antigen-like domains 1	Mus musculus	18-25
33004813-3	2020	Knockout (KO) of PINCH-1 increases dynamin-related protein 1 (DRP1) expression and mitochondrial fragmentation, which suppresses kindlin-2 mitochondrial translocation and interaction with pyrroline-5-carboxylate reductase 1 (PYCR1), resulting in inhibition of proline synthesis and cell proliferation.	Proline	260-267	LIM and senescent cell antigen-like domains 1	Mus musculus	17-24
33004813-3	2020	Knockout (KO) of PINCH-1 increases dynamin-related protein 1 (DRP1) expression and mitochondrial fragmentation, which suppresses kindlin-2 mitochondrial translocation and interaction with pyrroline-5-carboxylate reductase 1 (PYCR1), resulting in inhibition of proline synthesis and cell proliferation.	Proline	260-267	dynamin 1-like	Mus musculus	62-66
33004813-4	2020	Depletion of DRP1 reverses PINCH-1 deficiency-induced defects on mitochondrial dynamics, proline synthesis and cell proliferation.	Proline	89-96	dynamin 1-like	Mus musculus	13-17
33004813-5	2020	Furthermore, overexpression of PYCR1 in PINCH-1 KO cells restores proline synthesis and cell proliferation, and suppresses DRP1 expression and mitochondrial fragmentation.	Proline	66-73	pyrroline-5-carboxylate reductase 1	Mus musculus	31-36
33004813-5	2020	Furthermore, overexpression of PYCR1 in PINCH-1 KO cells restores proline synthesis and cell proliferation, and suppresses DRP1 expression and mitochondrial fragmentation.	Proline	66-73	LIM and senescent cell antigen-like domains 1	Mus musculus	40-47
33004813-6	2020	Finally, ablation of PINCH-1 from lung adenocarcinoma in mouse increases DRP1 expression and inhibits PYCR1 expression, proline synthesis, fibrosis and tumor growth.	Proline	120-127	LIM and senescent cell antigen-like domains 1	Mus musculus	21-28
33004813-7	2020	Our results identify a signaling axis consisting of PINCH-1, DRP1 and PYCR1 that regulates mitochondrial dynamics and proline synthesis, and suggest an attractive strategy for alleviation of tumor growth.	Proline	118-125	LIM and senescent cell antigen-like domains 1	Mus musculus	52-59
33004813-7	2020	Our results identify a signaling axis consisting of PINCH-1, DRP1 and PYCR1 that regulates mitochondrial dynamics and proline synthesis, and suggest an attractive strategy for alleviation of tumor growth.	Proline	118-125	dynamin 1-like	Mus musculus	61-65
33004813-7	2020	Our results identify a signaling axis consisting of PINCH-1, DRP1 and PYCR1 that regulates mitochondrial dynamics and proline synthesis, and suggest an attractive strategy for alleviation of tumor growth.	Proline	118-125	pyrroline-5-carboxylate reductase 1	Mus musculus	70-75
32917811-0	2020	Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids.	Proline	0-7	programmed cell death 6 interacting protein	Homo sapiens	29-33
32669367-0	2020	New proline, alanine, serine repeat sequence for pharmacokinetic enhancement of anti-VEGF single domain antibody.	Proline	4-11	vascular endothelial growth factor A	Mus musculus	85-89
32669367-2	2020	In the current study, for the first time, a novel proline, alanine, serine (PAS) repeat sequence, called PAS#208, was designed to extend the plasma half-life of a nano-sized anti-Vascular Endothelial Growth Factor-A single-domain antibody.	Proline	50-57	vascular endothelial growth factor A	Mus musculus	179-215
32863914-6	2020	The eukaryotic translation factor 5A (eIF5A), originally identified as an initiation factor, was later shown to promote translation elongation of iterated proline sequences.	Proline	155-162	eukaryotic translation initiation factor 5A	Homo sapiens	4-36
32863914-6	2020	The eukaryotic translation factor 5A (eIF5A), originally identified as an initiation factor, was later shown to promote translation elongation of iterated proline sequences.	Proline	155-162	eukaryotic translation initiation factor 5A	Homo sapiens	38-43
32710395-3	2020	PRODH/POX catalyzes conversion of proline into Delta1-pyrroline-5-carboxylate releasing ATP or reactive oxygen species for autophagy/apoptosis.	Proline	34-41	proline dehydrogenase 1	Homo sapiens	0-5
32917811-0	2020	Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids.	Proline	0-7	tumor susceptibility 101	Homo sapiens	52-58
32917811-2	2020	Using a "divide-and-conquer" approach, we present a detailed investigation of a PRD (166 residues; ~30% prolines) belonging to a human protein ALIX, a versatile adaptor protein involved in essential cellular processes including ESCRT-mediated membrane remodeling, cell adhesion, and apoptosis.	Proline	104-112	programmed cell death 6 interacting protein	Homo sapiens	143-147
32917811-4	2020	It contains three tandem sequentially similar proline-rich motifs that compete for a single binding site on its signaling partner, TSG101-UEV, as evidenced by heteronuclear NMR spectroscopy.	Proline	46-53	tumor susceptibility 101	Homo sapiens	131-137
32936182-0	2020	Oxidative damage of proline residues by nitrate radicals (NO3 ): a kinetic and product study.	Proline	20-27	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
32978391-0	2020	Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism.	Proline	53-60	mitochondrial calcium uniporter regulator 1	Homo sapiens	24-29
32978391-4	2020	Herein, we characterize Saccharomyces cerevisiae homologs Put6 and Put7 of MCUR1 as regulators of mitochondrial proline metabolism.	Proline	112-119	mitochondrial calcium uniporter regulator 1	Homo sapiens	75-80
32978391-7	2020	Yeast cells lacking either Put6 or Put7 exhibit a pronounced defect in proline utilization, which can be corrected by the heterologous expression of human MCUR1.	Proline	71-78	mitochondrial calcium uniporter regulator 1	Homo sapiens	155-160
32978391-8	2020	Our work uncovers an unexpected role of MCUR1 homologs in mitochondrial proline metabolism.	Proline	72-79	mitochondrial calcium uniporter regulator 1	Homo sapiens	40-45
33101333-4	2020	P5CS1 has been identified as the major contributor to stress-induced proline accumulation, whereas P5CS2 has been considered important for embryo development and growth.	Proline	69-76	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	0-5
33101333-6	2020	The comparison of the susceptibility of p5cs1 and p5cs2 mutants to infection with Pseudomonas syringae and salt stress provided novel information on the contribution of the two P5CS isoforms to proline accumulation and stress tolerance.	Proline	194-201	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	40-45
33101333-6	2020	The comparison of the susceptibility of p5cs1 and p5cs2 mutants to infection with Pseudomonas syringae and salt stress provided novel information on the contribution of the two P5CS isoforms to proline accumulation and stress tolerance.	Proline	194-201	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	50-55
33101333-7	2020	In agreement with previous studies, salt-stressed p5cs1 mutants accumulated very little proline, indicating that P5CS1 contributed more to stress-induced proline accumulation, whereas its impact on stress tolerance was rather weak.	Proline	88-95	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	50-55
33101333-7	2020	In agreement with previous studies, salt-stressed p5cs1 mutants accumulated very little proline, indicating that P5CS1 contributed more to stress-induced proline accumulation, whereas its impact on stress tolerance was rather weak.	Proline	154-161	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	113-118
33101333-8	2020	Germination and establishment of p5cs2 mutants were impaired under ambient conditions, further supporting that P5CS2 is most important for growth and development, whereas its contribution to stress-induced proline accumulation was smaller than that of P5CS1.	Proline	206-213	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	33-38
33101333-10	2020	These findings show that proline content, which was intermediate in leaves of p5cs2 mutants, was not directly correlated with stress tolerance in our experiments.	Proline	25-32	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	78-83
33101333-12	2020	Based on these data, we suggest a function of P5CS2 or P5CS2-mediated proline synthesis in regulating Na+ accumulation in leaves and thereby salt stress tolerance.	Proline	70-77	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	55-60
32687357-5	2020	Electron abstraction from the Pro residues induces the cleavage of both peptide and Calpha-C bonds, which is consistent with MALDI-ISD experimental results.	Proline	30-33	carbonic anhydrase 2	Homo sapiens	84-92
32938923-3	2020	We demonstrate coordinate induction of systemic muscle wasting with tumour-autonomous Yorkie-mediated SLC36-family amino acid transporter expression as a proline-scavenging programme to drive tumourigenesis.	Proline	154-161	yorkie	Drosophila melanogaster	86-92
32995773-5	2021	S2GDeltaHR2 elicited two-fold-higher NAb titers than the proline-capped spike (S2P), while S2GDeltaHR2 SApNPs derived from multilayered E2p and I3-01v9 60-mers elicited up to 10-fold higher NAb titers.	Proline	57-64	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	72-77
32699109-3	2020	The auxin transport activity of ABCB1 was suggested to be regulated by a physical interaction with FKBP42/Twisted Dwarf1 (TWD1), a peptidylprolyl cis-transisomerase (PPIase), but all attempts to demonstrate such a PPIase activity by TWD1 have failed so far.By using a structure-based approach, we identified several surface-exposed proline residues in the nucleotide binding domain and linker of Arabidopsis ABCB1, mutations of which do not alter ABCB1 protein stability or location but do affect its transport activity.	Proline	332-339	ATP binding cassette subfamily B1	Arabidopsis thaliana	32-37
32699109-3	2020	The auxin transport activity of ABCB1 was suggested to be regulated by a physical interaction with FKBP42/Twisted Dwarf1 (TWD1), a peptidylprolyl cis-transisomerase (PPIase), but all attempts to demonstrate such a PPIase activity by TWD1 have failed so far.By using a structure-based approach, we identified several surface-exposed proline residues in the nucleotide binding domain and linker of Arabidopsis ABCB1, mutations of which do not alter ABCB1 protein stability or location but do affect its transport activity.	Proline	332-339	FKBP-type peptidyl-prolyl cis-trans isomerase family protein	Arabidopsis thaliana	99-120
32699109-3	2020	The auxin transport activity of ABCB1 was suggested to be regulated by a physical interaction with FKBP42/Twisted Dwarf1 (TWD1), a peptidylprolyl cis-transisomerase (PPIase), but all attempts to demonstrate such a PPIase activity by TWD1 have failed so far.By using a structure-based approach, we identified several surface-exposed proline residues in the nucleotide binding domain and linker of Arabidopsis ABCB1, mutations of which do not alter ABCB1 protein stability or location but do affect its transport activity.	Proline	332-339	FKBP-type peptidyl-prolyl cis-trans isomerase family protein	Arabidopsis thaliana	122-126
32679097-5	2020	Mechanistically, O2 suppresses TRPA1 channel activity by protein internalization via O2-dependent proline hydroxylation and subsequent ubiquitination by an E3 ubiquitin ligase, NEDD4-1 (neural precursor cell-expressed developmentally down-regulated protein 4).	Proline	98-105	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	31-36
32679097-5	2020	Mechanistically, O2 suppresses TRPA1 channel activity by protein internalization via O2-dependent proline hydroxylation and subsequent ubiquitination by an E3 ubiquitin ligase, NEDD4-1 (neural precursor cell-expressed developmentally down-regulated protein 4).	Proline	98-105	neural precursor cell expressed, developmentally down-regulated 4	Mus musculus	177-184
32899962-7	2020	Moreover, increased proline oxidation capacity was detected in MPC1def flies, which was associated with generally lower levels of several metabolites, and particularly those involved in amino acid catabolism such as ornithine, citrulline, and arginosuccinate.	Proline	20-27	Mitochondrial pyruvate carrier	Drosophila melanogaster	63-70
32995289-5	2020	The PCCA gene sequencing revealed a novel homozygous missense variant affecting the locus (chr13:100962160) of exon 16 of the PCCA gene, resulting in the substitution of the amino acid arginine with proline at site 476 (p.Arg476Pro).	Proline	199-206	propionyl-CoA carboxylase subunit alpha	Homo sapiens	4-8
32995289-5	2020	The PCCA gene sequencing revealed a novel homozygous missense variant affecting the locus (chr13:100962160) of exon 16 of the PCCA gene, resulting in the substitution of the amino acid arginine with proline at site 476 (p.Arg476Pro).	Proline	199-206	propionyl-CoA carboxylase subunit alpha	Homo sapiens	126-130
32918543-1	2020	BACKGROUND/AIMS: Proline availability for proline dehydrogenase/proline oxidase (PRODH/POX) may represent switching mechanism between PRODH/POX-dependent apoptosis and autophagy.	Proline	17-24	proline dehydrogenase 1	Homo sapiens	81-86
32918543-1	2020	BACKGROUND/AIMS: Proline availability for proline dehydrogenase/proline oxidase (PRODH/POX) may represent switching mechanism between PRODH/POX-dependent apoptosis and autophagy.	Proline	17-24	proline dehydrogenase 1	Homo sapiens	134-139
32918543-4	2020	In order to targeting proline for PRODH/POX-dependent pathways substrate for prolidase, glycyl-proline (GP) was provided and proline utilization for collagen biosynthesis was blocked using 2-methoxyestradiol (MOE).	Proline	22-29	proline dehydrogenase 1	Homo sapiens	34-39
32918543-4	2020	In order to targeting proline for PRODH/POX-dependent pathways substrate for prolidase, glycyl-proline (GP) was provided and proline utilization for collagen biosynthesis was blocked using 2-methoxyestradiol (MOE).	Proline	22-29	peptidase D	Homo sapiens	77-86
32918543-4	2020	In order to targeting proline for PRODH/POX-dependent pathways substrate for prolidase, glycyl-proline (GP) was provided and proline utilization for collagen biosynthesis was blocked using 2-methoxyestradiol (MOE).	Proline	95-102	proline dehydrogenase 1	Homo sapiens	34-39
32918543-4	2020	In order to targeting proline for PRODH/POX-dependent pathways substrate for prolidase, glycyl-proline (GP) was provided and proline utilization for collagen biosynthesis was blocked using 2-methoxyestradiol (MOE).	Proline	95-102	peptidase D	Homo sapiens	77-86
32918543-10	2020	RESULTS: Prolidase overexpression in MCF-7PL cells contributed to 10-fold increase in the enzyme activity, 3-fold increase in cytoplasmic proline level and decrease in cell viability and DNA biosynthesis compared to wild type MCF-7 cells.	Proline	138-145	peptidase D	Homo sapiens	9-18
32918543-16	2020	CONCLUSION: The data suggest that overexpression of prolidase in MCF-7 cells contributes to increase in intracellular proline concentration and PRODH/POX-dependent autophagic cell death.	Proline	118-125	peptidase D	Homo sapiens	52-61
32598484-1	2020	Prolidase catalyzes the cleavage of dipeptides containing proline on their C-terminus.	Proline	58-65	peptidase D	Homo sapiens	0-9
32577828-4	2020	We show that one of these identified proteins, splicing factor proline and glutamine rich (SFPQ), is downregulated in the post-mortem brains of rapidly progressive AD patients, sCJD patients and 3xTg mice brain at terminal stage of the disease.	Proline	63-70	splicing factor proline and glutamine rich	Homo sapiens	91-95
32883027-0	2020	Proline Protects Boar Sperm against Oxidative Stress through Proline Dehydrogenase-Mediated Metabolism and the Amine Structure of Pyrrolidine.	Proline	0-7	proline dehydrogenase, mitochondrial	Canis lupus familiaris	61-82
32883027-7	2020	Addition of 75 mM proline not only significantly improved sperm membrane integrity, motility, and ATP levels but also maintained the redox homeostasis via increasing the GSH levels and activities of CAT and SOD.	Proline	18-25	catalase	Canis lupus familiaris	199-202
32883027-11	2020	Furthermore, addition of proline at 75 mM increased the activity of proline dehydrogenase (PRODH) and attenuated the H2O2-induced reduction in progressive motility.	Proline	25-32	proline dehydrogenase, mitochondrial	Canis lupus familiaris	68-89
32883027-11	2020	Furthermore, addition of proline at 75 mM increased the activity of proline dehydrogenase (PRODH) and attenuated the H2O2-induced reduction in progressive motility.	Proline	25-32	proline dehydrogenase, mitochondrial	Canis lupus familiaris	91-96
32883027-12	2020	These data demonstrate that proline protects sperm against oxidative stress through the secondary amine structure and proline dehydrogenase-mediated metabolism.	Proline	28-35	proline dehydrogenase, mitochondrial	Canis lupus familiaris	118-139
32327714-9	2020	ML364 potentiates the pro-degradation effects of HSP90 inhibitors on ErbB2 and hence sensitizes ErbB2-positive breast cancer cells to HSP90 inhibition.	Proline	22-25	heat shock protein 90 alpha family class A member 1	Homo sapiens	49-54
32327714-9	2020	ML364 potentiates the pro-degradation effects of HSP90 inhibitors on ErbB2 and hence sensitizes ErbB2-positive breast cancer cells to HSP90 inhibition.	Proline	22-25	erb-b2 receptor tyrosine kinase 2	Homo sapiens	69-74
32416637-1	2020	We aimed to investigate the association of single nucleotide polymorphism of Pro/Ala (rs1801282) in peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene with risk factors of diabetes mellitus (DM) in cardiovascular disease (CVD) patients.	Proline	77-80	peroxisome proliferator activated receptor gamma	Homo sapiens	100-148
32416637-1	2020	We aimed to investigate the association of single nucleotide polymorphism of Pro/Ala (rs1801282) in peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene with risk factors of diabetes mellitus (DM) in cardiovascular disease (CVD) patients.	Proline	77-80	peroxisome proliferator activated receptor gamma	Homo sapiens	150-160
32416637-6	2020	Further, serum biomarkers were measured to investigate the association among risk factors of DM and Pro/Ala polymorphism in PPAR-gamma gene.	Proline	100-103	peroxisome proliferator activated receptor gamma	Homo sapiens	124-134
32416637-11	2020	This study suggests that hyperglycemia in CAD-patients particularly obese, smokers and hypertensives having Pro/Ala polymorphism in PPAR-gamma gene are at high risk of developing DM as clearly observed by hyperglycemia in CAD-patients.	Proline	108-111	peroxisome proliferator activated receptor gamma	Homo sapiens	132-142
32535200-5	2020	Here, we identified IRSp53 as a new binding interactor of SHIP2 proline-rich domain.	Proline	64-71	BAR/IMD domain containing adaptor protein 2	Homo sapiens	20-26
32535200-5	2020	Here, we identified IRSp53 as a new binding interactor of SHIP2 proline-rich domain.	Proline	64-71	inositol polyphosphate phosphatase like 1	Homo sapiens	58-63
32610151-5	2020	On-NCCRP-1 possesses some inherent conservative domains, such as proline-rich motifs, antigen recognition site, and F-box-related domain.	Proline	65-72	F-box only protein 50	Oreochromis niloticus	3-10
32960509-4	2020	Supervised analysis identified two proteins of proline biosynthesis pathway, PYCR1 and ALDH18A1, that were significantly associated with resistance to treatment based on pattern dominance.	Proline	47-54	pyrroline-5-carboxylate reductase 1	Homo sapiens	77-82
32960509-4	2020	Supervised analysis identified two proteins of proline biosynthesis pathway, PYCR1 and ALDH18A1, that were significantly associated with resistance to treatment based on pattern dominance.	Proline	47-54	aldehyde dehydrogenase 18 family member A1	Homo sapiens	87-95
32470317-0	2020	A Conserved Proline Hinge Mediates Helix Dynamics and Activation of Rhodopsin.	Proline	12-19	rhodopsin	Homo sapiens	68-77
32574985-1	2020	Proline dehydrogenase (ProDH) is a flavoenzyme that catalyzes the oxidation of proline (Pro) into Delta1-pyrroline-5-carboxylate (P5C).	Proline	79-86	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	0-21
32574985-1	2020	Proline dehydrogenase (ProDH) is a flavoenzyme that catalyzes the oxidation of proline (Pro) into Delta1-pyrroline-5-carboxylate (P5C).	Proline	79-86	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	23-28
32574985-1	2020	Proline dehydrogenase (ProDH) is a flavoenzyme that catalyzes the oxidation of proline (Pro) into Delta1-pyrroline-5-carboxylate (P5C).	Proline	0-3	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	23-28
32943819-5	2020	According to findings, sos5-1 mutant plants treated with ABA under salt stress resulted in eliminated cellular damage compared to those which are solely exposed to salt stress; other observations include closing of stomata, decreased H2O2 content, increased amount of proline, and similarity with the wild type due to induced antioxidant enzyme activities.	Proline	268-275	Fasciclin-like arabinogalactan family protein	Arabidopsis thaliana	23-27
32470317-2	2020	Here, we use solid-state NMR and Fourier transform infrared spectroscopy on rhodopsin to show that Trp2656.48 within the CWxP motif on transmembrane helix H6 constrains a proline hinge in the inactive state, suggesting that activation results in unraveling of the H6 backbone within this motif, a local change in dynamics that allows helix H6 to swing outward.	Proline	171-178	rhodopsin	Homo sapiens	76-85
32200708-5	2020	To moderately prolong its plasma half-life and, thus, increase tumor uptake, the recombinant Fab was fused with a long disordered amino acid chain comprising Pro, Ala and Ser residues (PASylation).	Proline	158-161	FA complementation group B	Homo sapiens	93-96
32611237-0	2020	Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-fibrotic Protein Synthesis During Cardiac Fibrosis.	Proline	42-49	glutamyl-prolyl-tRNA synthetase	Mus musculus	0-31
32621833-2	2020	Peptidyl-prolyl isomerase (Pin1) is a unique peptidyl-prolyl cis/trans isomerase that interacts with phosphorylated serine or threonine of a target protein and isomerizes the adjacent proline residue.	Proline	184-191	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	27-31
32611237-7	2020	Inhibition of EPRS using a prolyl-tRNA synthetase (PRS)-specific inhibitor, halofuginone (Halo), significantly decreases translation efficiency of proline-rich collagens in cardiac fibroblasts as well as TGF-beta-activated myofibroblasts.	Proline	147-154	glutamyl-prolyl-tRNA synthetase	Mus musculus	14-18
32611237-13	2020	Conclusions: Our results indicate that EPRS preferentially controls translational activation of proline codon rich pro-fibrotic genes in cardiac fibroblasts and augments pathological cardiac remodeling.	Proline	96-103	glutamyl-prolyl-tRNA synthetase	Mus musculus	39-43
32764370-9	2020	By a modified capture hybridization (CHART) analysis of the protein targets, we uncovered interactions of Morrbid lncRNA with the SFPQ (splicing factor proline and glutamine rich)-NONO (non-POU domain-containing octamer-binding protein) splicing complex.	Proline	152-159	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	Mus musculus	130-134
32479955-6	2020	Structural studies of PIM kinases revealed that they have unique hinge regions where two Proline resides and makes ATP binding unique, by offering a target for an increasing number of potent PIM kinase inhibitors.	Proline	89-96	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	22-25
32479955-6	2020	Structural studies of PIM kinases revealed that they have unique hinge regions where two Proline resides and makes ATP binding unique, by offering a target for an increasing number of potent PIM kinase inhibitors.	Proline	89-96	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	191-194
32640193-3	2020	However, the proline residue of DYRK1 targeted by hydroxylation and the role of prolyl hydroxylation in tyrosine autophosphorylation of DYRK1 are unknown.	Proline	13-20	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	32-37
32640193-4	2020	We found that a highly conserved proline in the CMGC insert of the DYRK1 kinase domain is hydroxylated by PHD1, and this event precedes tyrosine autophosphorylation.	Proline	33-40	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	67-72
32640193-4	2020	We found that a highly conserved proline in the CMGC insert of the DYRK1 kinase domain is hydroxylated by PHD1, and this event precedes tyrosine autophosphorylation.	Proline	33-40	egl-9 family hypoxia inducible factor 2	Homo sapiens	106-110
32640193-5	2020	Mutation of the hydroxylation acceptor proline precludes tyrosine autophosphorylation and folding of DYRK1, resulting in a kinase unable to preserve VHL function and lacking glioma suppression activity.	Proline	39-46	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	101-106
32640193-5	2020	Mutation of the hydroxylation acceptor proline precludes tyrosine autophosphorylation and folding of DYRK1, resulting in a kinase unable to preserve VHL function and lacking glioma suppression activity.	Proline	39-46	von Hippel-Lindau tumor suppressor	Homo sapiens	149-152
32859127-6	2020	The amino (N)-terminal domain (NTD) of CENP-A has been implicated in this regulation and shown to be dependent on the proline residues within this domain in Saccharomyces cerevisiae CENP-A, Cse4.	Proline	118-125	centromeric DNA-binding histone H3-like protein CSE4	Saccharomyces cerevisiae S288C	190-194
32824561-1	2020	Prolidase [EC 3.4.13.9], known as PEPD, cleaves di- and tripeptides containing carboxyl-terminal proline or hydroxyproline.	Proline	97-104	peptidase D	Homo sapiens	0-9
32824561-1	2020	Prolidase [EC 3.4.13.9], known as PEPD, cleaves di- and tripeptides containing carboxyl-terminal proline or hydroxyproline.	Proline	97-104	peptidase D	Homo sapiens	34-38
32851152-5	2020	Furthermore, introduction of a helix-breaking proline residue in H8 elicited an increase in ss-arrestin-NTS1 interactions observed in pull-down assays, suggesting that the structure and/or dynamics of H8 might play an important role in GPCR signaling.	Proline	46-53	neurotensin	Homo sapiens	104-108
32764370-9	2020	By a modified capture hybridization (CHART) analysis of the protein targets, we uncovered interactions of Morrbid lncRNA with the SFPQ (splicing factor proline and glutamine rich)-NONO (non-POU domain-containing octamer-binding protein) splicing complex.	Proline	152-159	non-POU-domain-containing, octamer binding protein	Mus musculus	180-184
32759884-6	2020	Therefore, overexpression of tobacco osmotin protein in transgenic plants protects them from different stresses by reducing reactive oxygen species (ROS) production, limiting lipid peroxidation, initiating programmed cell death (PCD), and increasing proline content and scavenging enzyme activity.	Proline	250-257	osmotin	Nicotiana tabacum	37-44
32745097-2	2020	Here we show that Scar/WAVE"s proline-rich domain is polyphosphorylated after the complex is activated.	Proline	30-37	ribosomal protein S4 X-linked	Homo sapiens	18-22
32276028-4	2020	rs148077750 is a missense leucine to proline substitution in IL13.	Proline	37-44	interleukin 13	Homo sapiens	61-65
32953737-2	2020	Pyrroline-5-carboxylate reductase 1 (PYCR1) is the key enzyme in intracellular proline synthesis, but its role in GC remains largely unknown.	Proline	79-86	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-35
32953737-2	2020	Pyrroline-5-carboxylate reductase 1 (PYCR1) is the key enzyme in intracellular proline synthesis, but its role in GC remains largely unknown.	Proline	79-86	pyrroline-5-carboxylate reductase 1	Homo sapiens	37-42
32267539-6	2020	In the MTHFR group, 1-monohexadecanoylglycerol, pyrophosphate, benzoin, and linoleic acid were found to be significantly decreased (p   0.05 for all), whereas glyceric acid, L-tryptophan, L-alanine, L-proline, norvaline, L-threonine, and myo-inositol were significantly increased (p   0.01 for the first 2 metabolites, p   0.05 for the others) at 11-14 gestational weeks.	Proline	199-208	methylenetetrahydrofolate reductase	Homo sapiens	7-12
32267539-7	2020	Conversely, benzoin, 1-monohexadecanoylglycerol, pyruvic acid, L-proline, phosphoric acid, epsilon-caprolactam, and pipecolic acid were significantly decreased in the MTHFR group, whereas metabolites such as hexadecanoic acid and 2-hydroxybutyric acid increased significantly in the study group during delivery.	Proline	63-72	methylenetetrahydrofolate reductase	Homo sapiens	167-172
32559510-1	2020	An efficient three component coupling of aromatic aldehyde, deoxy sugar based alkyne (alpha-2-deoxy propargyl glycoside) and heterocyclic amine have been refluxed to synthesize stereoselective chiral propargylamines with good to excellent yield using only CuI catalyst along with bifunctional ligand l-proline.	Proline	300-309	glycoprotein hormone subunit alpha 2	Homo sapiens	86-93
32559510-4	2020	The ligand l-proline was used for the first time in enantioselective A3-coupling reaction of alpha-2-deoxy propargyl glycosides involving substituted aromatic aldehyde and heterocyclic amines.	Proline	11-20	glycoprotein hormone subunit alpha 2	Homo sapiens	93-100
32661324-6	2020	Mechanistically, LINC01503 recruited splicing factor proline-and glutamine-rich (SFPQ) to activate Fos like 1 (FOSL1) transcription, and ectopic expression of FOSL1 reversed the suppressive effect of LINC01503 knockdown on NPC progression.	Proline	53-60	splicing factor proline and glutamine rich	Homo sapiens	81-85
32289446-6	2020	This interaction is mediated by proline-rich motifs within the C-terminus of FAM83H, specifically interacting with the second and third SH3 domains of NCK1/2.	Proline	32-39	family with sequence similarity 83 member H	Homo sapiens	77-83
32430722-4	2020	Glutamate dehydrogenase (GDH) activity was generally enhanced, accompanied by increases of 0.4- to 1.9-fold in proline levels, revealing GDH as an important compensatory route for both N assimilation and proline production under stressful conditions.	Proline	204-211	glutamate dehydrogenase	Solanum lycopersicum	0-23
32430722-4	2020	Glutamate dehydrogenase (GDH) activity was generally enhanced, accompanied by increases of 0.4- to 1.9-fold in proline levels, revealing GDH as an important compensatory route for both N assimilation and proline production under stressful conditions.	Proline	204-211	glutamate dehydrogenase	Solanum lycopersicum	25-28
32430722-4	2020	Glutamate dehydrogenase (GDH) activity was generally enhanced, accompanied by increases of 0.4- to 1.9-fold in proline levels, revealing GDH as an important compensatory route for both N assimilation and proline production under stressful conditions.	Proline	204-211	glutamate dehydrogenase	Solanum lycopersicum	137-140
32430722-4	2020	Glutamate dehydrogenase (GDH) activity was generally enhanced, accompanied by increases of 0.4- to 1.9-fold in proline levels, revealing GDH as an important compensatory route for both N assimilation and proline production under stressful conditions.	Proline	111-118	glutamate dehydrogenase	Solanum lycopersicum	0-23
32430722-4	2020	Glutamate dehydrogenase (GDH) activity was generally enhanced, accompanied by increases of 0.4- to 1.9-fold in proline levels, revealing GDH as an important compensatory route for both N assimilation and proline production under stressful conditions.	Proline	111-118	glutamate dehydrogenase	Solanum lycopersicum	25-28
32661324-6	2020	Mechanistically, LINC01503 recruited splicing factor proline-and glutamine-rich (SFPQ) to activate Fos like 1 (FOSL1) transcription, and ectopic expression of FOSL1 reversed the suppressive effect of LINC01503 knockdown on NPC progression.	Proline	53-60	long intergenic non-protein coding RNA 1503	Homo sapiens	17-26
32428517-4	2020	Pin1 is able to recognize phosphorylated serine/threonine-proline motifs and regulates the structural conformation, stability and function of its substrates.	Proline	58-65	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
32752665-3	2020	The C-terminal proline-rich (PR) domain of SOS1 regulates nSH3 open/closed conformations.	Proline	15-22	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	43-47
32602701-11	2020	Most Pro residues within the short collagen domain of myonectin were also hydroxylated, a modification that stabilized the collagen triple helix.	Proline	5-8	erythroferrone	Homo sapiens	54-63
32727419-8	2020	CONCLUSIONS: This pilot study suggests that both the Arg/Arg and Arg/Pro genotypes of p53 codon 72 polymorphism may have value as independent prognostic or predictive parameters for bevacizumab treatment response and failure.	Proline	69-72	tumor protein p53	Homo sapiens	86-89
32793273-8	2020	To position salt stress tolerance studies in the context of a crop plant growing in the field, here we discuss the beneficial effects of exogenous proline on plants exposed to salt stress through well-known and more recently described examples in more than twenty crop species in order to appreciate both the diversity and commonality of the responses.	Proline	147-154	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	264-268
32722521-4	2020	By producing L-ornithine while competing with nitric oxide synthase (NOS) for the same substrate (L-arginine), arginase can influence the endogenous levels of polyamines, proline, and NO .	Proline	171-178	nitric oxide synthase 2	Homo sapiens	46-67
32703934-2	2020	PIN1, belonging to peptidyl-prolyl cis-trans isomerase family, uniquely catalyzes the structural transformation of phosphorylated Ser/Thr-Pro motif.	Proline	138-141	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
32793273-0	2020	How Does Proline Treatment Promote Salt Stress Tolerance During Crop Plant Development?	Proline	9-16	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	64-68
32793273-9	2020	Proposed mechanisms by which exogenous proline mitigates the detrimental effects of salt stress during crop plant growth are thus highlighted and critically assessed.	Proline	39-46	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	103-107
32832664-6	2020	Phosphorylation of tau by GSK3beta, a major proline-directed tau kinase, modulates tau degradation kinetics in a residue-specific manner.	Proline	44-51	glycogen synthase kinase 3 alpha	Homo sapiens	26-34
32470293-9	2020	We further developed a proline-based co-selection by using S. cerevisiae PRO1 and PRO2 genes as markers, which enables the generation of 99.5% double-transgenic cells.	Proline	23-30	glutamate 5-kinase	Saccharomyces cerevisiae S288C	73-77
32708183-5	2020	WIP consists of consecutive small functional domains and motifs that interact with a host of cellular partners, with a striking preponderance of proline-rich motif capable of interactions with several well-recognized binding partners; indeed, over 30% of the WIP primary structure are proline residues.	Proline	145-152	WAS/WASL interacting protein family member 1	Homo sapiens	0-3
32708183-5	2020	WIP consists of consecutive small functional domains and motifs that interact with a host of cellular partners, with a striking preponderance of proline-rich motif capable of interactions with several well-recognized binding partners; indeed, over 30% of the WIP primary structure are proline residues.	Proline	145-152	WAS/WASL interacting protein family member 1	Homo sapiens	259-262
32708183-5	2020	WIP consists of consecutive small functional domains and motifs that interact with a host of cellular partners, with a striking preponderance of proline-rich motif capable of interactions with several well-recognized binding partners; indeed, over 30% of the WIP primary structure are proline residues.	Proline	285-292	WAS/WASL interacting protein family member 1	Homo sapiens	0-3
32501498-8	2020	Surprisingly, sequence interrogation of ~300 significantly down-regulated phosphoproteins reveals an extensive network of centrinone-sensitive [Ser/Thr]Pro phosphorylation sequence motifs, which based on our analysis might be either direct or indirect targets of PLK4.	Proline	152-155	polo like kinase 4	Homo sapiens	263-267
32708436-3	2020	Using this model, we previously showed that a pathogenic mutation in mitochondrial ATP6 gene (m.9191T>C), that converts a highly conserved leucine residue into proline in human ATP synthase subunit a (aL222P), severely compromises the assembly of yeast ATP synthase and reduces by 90% the rate of mitochondrial ATP synthesis.	Proline	160-167	mitochondrially encoded ATP synthase 6	Homo sapiens	83-87
32576582-6	2020	The early-stage induction of autophagy was characterized mainly by the activation of biosynthetic and metabolic processes through up- or down-regulation of the critical autophagic regulatory proteins Sequestosome-1 (SQSTM1) and proline-rich AKT1 substrate 1 (AKT1S1).	Proline	228-235	AKT1 substrate 1	Homo sapiens	241-257
32459350-6	2020	Through its Pro-Trp-Trp-Pro (PWWP) domain, HRP2 preferentially binds to H3K36me2.	Proline	12-15	HDGF like 2	Mus musculus	43-47
32803092-5	2020	PRRT3 belongs to the family of proline-rich proteins containing several repeats of a short proline-rich sequence, but its function remains to be determined.	Proline	31-38	proline rich transmembrane protein 3	Homo sapiens	0-5
32803092-5	2020	PRRT3 belongs to the family of proline-rich proteins containing several repeats of a short proline-rich sequence, but its function remains to be determined.	Proline	91-98	proline rich transmembrane protein 3	Homo sapiens	0-5
32330411-1	2020	Patients lacking PYCR2, a mitochondrial enzyme that synthesizes proline, display postnatal degenerative microcephaly with hypomyelination.	Proline	64-71	pyrroline-5-carboxylate reductase 2	Homo sapiens	17-22
32402249-1	2020	The causative agent of Huntington"s disease, the poly-Q homo-repeat in the N-terminal region of huntingtin (httex1), is flanked by a 17-residue-long fragment (N17) and a proline-rich region (PRR), which promote and inhibit the aggregation propensity of the protein, respectively, by poorly understood mechanisms.	Proline	170-177	huntingtin	Homo sapiens	96-106
32711437-12	2020	Significant increased risk of lung cancer was found with Arg/Pro genotypes of TP53, Lys/Gln and Gln/Gln variants of XPD in individuals with family history of cancer (OR=3.44; 95% CI=1.36-8.72; p=0.011; OR=3.17; 95% CI=1.20-8.39; p=0.024; OR=16.35; 95% CI=0.92-289.5; p=0.007, respectively).	Proline	61-64	tumor protein p53	Homo sapiens	78-82
32711437-12	2020	Significant increased risk of lung cancer was found with Arg/Pro genotypes of TP53, Lys/Gln and Gln/Gln variants of XPD in individuals with family history of cancer (OR=3.44; 95% CI=1.36-8.72; p=0.011; OR=3.17; 95% CI=1.20-8.39; p=0.024; OR=16.35; 95% CI=0.92-289.5; p=0.007, respectively).	Proline	61-64	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	116-119
32354853-6	2020	Using peptide microarrays and MS/MS based analysis methods, we show that the proline-rich stretch surrounding P366 mediates binding to syndapin I, a F-BAR domain protein involved in membrane remodeling.	Proline	77-84	protein kinase C and casein kinase substrate in neurons 1	Homo sapiens	135-145
32627042-0	2020	Proline-rich polypeptide-1 decreases cancer stem cell population by targeting BAFF chromatin-remodeling complexes in human chondrosarcoma JJ012 cells.	Proline	0-7	TNF superfamily member 13b	Homo sapiens	78-82
32513738-2	2020	GID4, a subunit of the GID ubiquitin ligase, is the main recognition component of the proline (Pro)/N-degron pathway.	Proline	86-93	GID complex subunit 4 homolog	Homo sapiens	0-4
32513738-2	2020	GID4, a subunit of the GID ubiquitin ligase, is the main recognition component of the proline (Pro)/N-degron pathway.	Proline	95-98	GID complex subunit 4 homolog	Homo sapiens	0-4
32513738-3	2020	GID4 targets proteins through their Nt-Pro residue or a Pro at position 2, in the presence of specific downstream sequence motifs.	Proline	39-42	GID complex subunit 4 homolog	Homo sapiens	0-4
32513738-4	2020	Here we show that human GID4 can also recognize hydrophobic Nt-residues other than Pro.	Proline	83-86	GID complex subunit 4 homolog	Homo sapiens	24-28
32637352-2	2020	P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit melanoma development by decreasing intracellular proline levels to increase the phosphorylation of eIF2alpha mediated by GCN2, which then impairs mRNA translation.	Proline	20-27	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-4
32637352-2	2020	P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit melanoma development by decreasing intracellular proline levels to increase the phosphorylation of eIF2alpha mediated by GCN2, which then impairs mRNA translation.	Proline	150-157	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-4
32637352-2	2020	P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit melanoma development by decreasing intracellular proline levels to increase the phosphorylation of eIF2alpha mediated by GCN2, which then impairs mRNA translation.	Proline	150-157	aldehyde dehydrogenase 18 family member A1	Homo sapiens	55-63
32552912-12	2020	In addition, via its proline rich domain, RIN3 recruited BIN1(bridging integrator 1) and CD2AP (CD2 associated protein), two other AD risk factors, to early endosomes.	Proline	21-28	Ras and Rab interactor 3	Mus musculus	42-46
32552912-12	2020	In addition, via its proline rich domain, RIN3 recruited BIN1(bridging integrator 1) and CD2AP (CD2 associated protein), two other AD risk factors, to early endosomes.	Proline	21-28	bridging integrator 1	Mus musculus	57-61
32552912-12	2020	In addition, via its proline rich domain, RIN3 recruited BIN1(bridging integrator 1) and CD2AP (CD2 associated protein), two other AD risk factors, to early endosomes.	Proline	21-28	bridging integrator 1	Mus musculus	62-83
32552912-12	2020	In addition, via its proline rich domain, RIN3 recruited BIN1(bridging integrator 1) and CD2AP (CD2 associated protein), two other AD risk factors, to early endosomes.	Proline	21-28	CD2-associated protein	Mus musculus	89-94
32377733-7	2020	The proline hydroxylation of HIF-1alpha by prolyl hydroxylases (PHDs) was previously discovered to be responsible for the rapid degradation of HIF-1alpha.	Proline	4-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-39
32377733-7	2020	The proline hydroxylation of HIF-1alpha by prolyl hydroxylases (PHDs) was previously discovered to be responsible for the rapid degradation of HIF-1alpha.	Proline	4-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	143-153
32371045-4	2020	We found SHTN1 contains a noncanonical WH2 domain and an upstream proline rich region (PRR) that by themselves are sufficient for actin interaction.	Proline	66-73	shootin 1	Homo sapiens	9-14
32576835-3	2020	Alpha synuclein (alphaSyn) is shown here to interact directly with CypD via its acidic proline-rich C-terminus region and binding at the putative ligand binding pocket of CypD.	Proline	87-94	synuclein alpha	Homo sapiens	0-15
32576835-3	2020	Alpha synuclein (alphaSyn) is shown here to interact directly with CypD via its acidic proline-rich C-terminus region and binding at the putative ligand binding pocket of CypD.	Proline	87-94	synuclein alpha	Homo sapiens	17-25
32576835-3	2020	Alpha synuclein (alphaSyn) is shown here to interact directly with CypD via its acidic proline-rich C-terminus region and binding at the putative ligand binding pocket of CypD.	Proline	87-94	peptidylprolyl isomerase D	Homo sapiens	67-71
32569527-4	2020	A ZP2-ZP3 dimer is located periodically along ZP fibrils that are cross-linked by ZP1, a protein with a proline-rich N terminus.	Proline	104-111	zona pellucida glycoprotein 2	Homo sapiens	2-5
32569527-4	2020	A ZP2-ZP3 dimer is located periodically along ZP fibrils that are cross-linked by ZP1, a protein with a proline-rich N terminus.	Proline	104-111	zona pellucida glycoprotein 3	Homo sapiens	6-9
32569527-4	2020	A ZP2-ZP3 dimer is located periodically along ZP fibrils that are cross-linked by ZP1, a protein with a proline-rich N terminus.	Proline	104-111	zona pellucida glycoprotein 1	Homo sapiens	82-85
32354853-11	2020	A proline-rich stretch in this receptor domain forms a non-canonical recognition motif important for the interaction with syndapin I (PACSIN1).	Proline	2-9	protein kinase C and casein kinase substrate in neurons 1	Homo sapiens	122-132
32354853-11	2020	A proline-rich stretch in this receptor domain forms a non-canonical recognition motif important for the interaction with syndapin I (PACSIN1).	Proline	2-9	protein kinase C and casein kinase substrate in neurons 1	Homo sapiens	134-141
32553169-0	2020	Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization.	Proline	0-7	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	31-34
32459490-3	2020	A syn-selective self-Mannich reaction catalyzed by proline is utilized for the asymmetric synthesis of the diastereomer, (+)-laburnine, and its enantiomer, (-)-trachelanthamidine.	Proline	51-58	synemin	Homo sapiens	2-5
32532261-2	2020	In genetically predisposed individuals with HLA DQ2/DQ8 molecules, the gluten domains rich in glutamine and proline present gluten domains to gluten reactive CD4+ T cells causing injury to the intestine.	Proline	108-115	torsin family 1 member A	Homo sapiens	48-51
32532261-2	2020	In genetically predisposed individuals with HLA DQ2/DQ8 molecules, the gluten domains rich in glutamine and proline present gluten domains to gluten reactive CD4+ T cells causing injury to the intestine.	Proline	108-115	CD4 molecule	Homo sapiens	158-161
32372643-9	2020	Mutation of R92 to Pro, a residue found in Kir6.2, results in promiscuous binding of PIP isoforms.	Proline	19-22	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	43-49
32372643-9	2020	Mutation of R92 to Pro, a residue found in Kir6.2, results in promiscuous binding of PIP isoforms.	Proline	19-22	prolactin induced protein	Homo sapiens	85-88
32317279-2	2020	The interaction was suggested to be important for the amplification of TCR signals and is governed by a proline-rich sequence (PRS) in CD3&epsilon; that binds to the first SH3 domain of Nck (Nck-SH3.1).	Proline	104-111	CD3 antigen, epsilon polypeptide	Mus musculus	135-146
32317279-2	2020	The interaction was suggested to be important for the amplification of TCR signals and is governed by a proline-rich sequence (PRS) in CD3&epsilon; that binds to the first SH3 domain of Nck (Nck-SH3.1).	Proline	104-111	non-catalytic region of tyrosine kinase adaptor protein 1	Mus musculus	186-189
32317279-2	2020	The interaction was suggested to be important for the amplification of TCR signals and is governed by a proline-rich sequence (PRS) in CD3&epsilon; that binds to the first SH3 domain of Nck (Nck-SH3.1).	Proline	104-111	non-catalytic region of tyrosine kinase adaptor protein 1	Mus musculus	191-200
32617526-6	2020	In addition, molecular dynamics modeling suggested that hydrophobic amino acid residues (Phe 111, Leu 10, Ala 115, Pro 116) in pepsin and polar amino acid residues (Tyr 146, Thr 95) in myoglobin were found in the proximity of binding sites, which could result in the low digestibility of myoglobin.	Proline	115-118	myoglobin	Homo sapiens	185-194
32468886-7	2020	Domain swap experiments mixing SH2 (phosphotyrosine binding) and SH3 (proline-rich binding) domains between Nck1 and Nck2 showed a dispensable role for SH2 domains but a critical role for the Nck1 SH3 domains in rescuing disturbed flow-induced endothelial permeability.	Proline	70-77	NCK adaptor protein 1	Homo sapiens	108-112
32468886-7	2020	Domain swap experiments mixing SH2 (phosphotyrosine binding) and SH3 (proline-rich binding) domains between Nck1 and Nck2 showed a dispensable role for SH2 domains but a critical role for the Nck1 SH3 domains in rescuing disturbed flow-induced endothelial permeability.	Proline	70-77	NCK adaptor protein 2	Homo sapiens	117-121
32255678-8	2020	Our data suggest that alanine, arginine, cysteine, and proline, but not glutamine, are involved in the acute regulation of the liver-alpha-cell axis in female mice, as they all increased glucagon secretion and their disappearance rate was altered by GRA.	Proline	55-62	glucagon	Mus musculus	187-195
32247045-3	2020	Sequence analysis showed that On-CD2AP protein shares high similarity with mammals, including three Src homology 3 (SH3) domains, a section of poly proline motif and a coiled coil region.	Proline	148-155	macrophage stimulating 1 receptor	Rattus norvegicus	30-32
32592343-1	2020	BACKGROUND: A transversion missense polymorphism of the TP53 tumor suppressor gene at the codon 72 codes proline instead of arginine causes an altered p53 protein expression and has been found to be associated with an elevated risk of various cancer; especially breast and lung cancer.	Proline	105-112	tumor protein p53	Homo sapiens	56-60
32592343-1	2020	BACKGROUND: A transversion missense polymorphism of the TP53 tumor suppressor gene at the codon 72 codes proline instead of arginine causes an altered p53 protein expression and has been found to be associated with an elevated risk of various cancer; especially breast and lung cancer.	Proline	105-112	tumor protein p53	Homo sapiens	151-154
32490521-5	2020	Metabolic reactions linked to arginase were also affected, since urease-positive and urease-negative cells differed with respect to agmatinase activity, polyamine synthesis, as well as intracellular levels of proline and reactive oxygen species.	Proline	209-216	urease	Cryptococcus neoformans var. grubii H99	85-91
32278739-0	2020	Proline 285 is integral for the reactivation of organophosphate-inhibited human butyrylcholinesterase by 2-PAM.	Proline	0-7	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	107-110
32247045-3	2020	Sequence analysis showed that On-CD2AP protein shares high similarity with mammals, including three Src homology 3 (SH3) domains, a section of poly proline motif and a coiled coil region.	Proline	148-155	CD2-associated protein	Oreochromis niloticus	33-38
32494070-5	2020	A proline-arginine-rich sequence within the LCD binds to microtubules and targets condensation of LEM2 to spindle microtubules that traverse the nascent nuclear envelope.	Proline	2-9	LEM domain nuclear envelope protein 2	Homo sapiens	98-102
32424519-5	2020	The results indicate that the TP53 Arg/Pro heterozygosity (adjusted OR   2.32, 95% CI  1.28-4.34, p = 0.01), Pro/Pro mutant homozygosity (adjusted OR  4.15, 95% CI  1.75-9.86, p = 0.001), along with the combined genotype (Arg/Pro + Pro/Pro) (adjusted OR  2.83, 95% CI  1.61-4.97, p < 0.001) significantly increases the risk of cervical cancer.	Proline	39-42	tumor protein p53	Homo sapiens	30-34
32424519-6	2020	Moreover, the cervical cancer patients with a first-degree relative cancer patient possesses 4.45 folds more risk (p = 0.019) of carrying a proline allele in codon 72 of the TP53 gene compared to those patients who do not have any first-degree relative with cancer.	Proline	140-147	tumor protein p53	Homo sapiens	174-178
32344996-8	2020	NS5A interacted with LASP-1 through the proline motif in domain I of NS5A and the tryptophan residue in the SH3 domain of LASP-1.	Proline	40-47	LIM and SH3 protein 1	Homo sapiens	21-27
32574548-8	2020	These results define the molecular mechanisms determining DVL regulation by KLHL12 and establish the KLHL12 Kelch domain as a new protein interaction module for a novel proline-rich motif.	Proline	169-176	dishevelled segment polarity protein 1	Homo sapiens	58-61
32574548-8	2020	These results define the molecular mechanisms determining DVL regulation by KLHL12 and establish the KLHL12 Kelch domain as a new protein interaction module for a novel proline-rich motif.	Proline	169-176	kelch like family member 12	Homo sapiens	101-107
32574548-8	2020	These results define the molecular mechanisms determining DVL regulation by KLHL12 and establish the KLHL12 Kelch domain as a new protein interaction module for a novel proline-rich motif.	Proline	169-176	kelch like family member 2	Homo sapiens	108-113
32486279-6	2020	The relative abundances of methionine, proline, and alpha-lactose were the highest in beta-casein variant A2 milk, whereas choline, glycine, citric acid, and cyclic adenosine monophosphate (cAMP) showed the highest abundances in variant A1 milk.	Proline	39-46	casein beta	Bos taurus	86-97
32472079-1	2020	Three missense mutations targeting the same proline 209 (Pro209) codon in the co-chaperone Bcl2-associated athanogene 3 (BAG3) have been reported to cause distal myopathy, dilated cardiomyopathy or Charcot-Marie-Tooth type 2 neuropathy.	Proline	44-51	BAG cochaperone 3	Homo sapiens	91-119
32547410-1	2020	The Proline, Glutamate, Valine and Lysine-rich (PEVK) region of titin constitutes an entropic spring that provides passive tension to striated muscle.	Proline	4-11	titin	Mus musculus	64-69
32472079-1	2020	Three missense mutations targeting the same proline 209 (Pro209) codon in the co-chaperone Bcl2-associated athanogene 3 (BAG3) have been reported to cause distal myopathy, dilated cardiomyopathy or Charcot-Marie-Tooth type 2 neuropathy.	Proline	44-51	BAG cochaperone 3	Homo sapiens	121-125
32471205-6	2020	Carprofen and Celecoxib have been selected by the COVID Moonshot initiative for in vitro testing; they show 3.97 and 11.90% M-pro inhibition at 50 microM, respectively.	Proline	3-6	membrane glycoprotein	Severe acute respiratory syndrome coronavirus 2	56-57
32217692-10	2020	Our findings also reveal several residues in MxB, including Pro-515, critical for its oligomerization and anti-HIV-1 function.	Proline	60-63	MX dynamin like GTPase 2	Homo sapiens	45-48
32455636-1	2020	Prolidase is a ubiquitous enzyme that plays a major role in the metabolism of proline-rich proteins.	Proline	78-85	peptidase D	Homo sapiens	0-9
32550227-7	2020	These sites were codes for amino acids such as arginine, proline, lysine, and leucine indicating major roles for the function of immunological proteins, and in particular, the study highlighted the importance of changes in gene expression of AKT3 on immunity.	Proline	57-64	AKT serine/threonine kinase 3	Homo sapiens	242-246
32500074-3	2020	The peptidyl-prolyl cis/trans isomerase Pin1 binds to phosphorylated serine or threonine residues preceding proline and regulates the biological functions of its substrates.	Proline	108-115	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	40-44
32500081-3	2020	The analog of the amino acid proline, cis-4-[18F]fluoro-L-proline ([18F]fluoro-proline), which targets collagenogenesis in hepatic stellate cells (HSC), was used to detect fibrosis.	Proline	29-36	suppressor of cytokine signaling 6	Mus musculus	38-43
32397251-6	2020	Compared to wild-type plants, when exposed to salt stress, Arabidopsis plants overexpressing SOS1 C-term showed improved salt tolerance, significantly reduced Na+ accumulation in leaves, reduced induction of the salt-responsive gene WRKY25, decreased soluble sugar, starch, and proline levels, less impaired inflorescence formation and increased biomass.	Proline	278-285	sodium proton exchanger, putative (NHX7) (SOS1)	Arabidopsis thaliana	93-97
32297517-5	2020	We redesigned Sphaerobacter thermophiles PEP with high-temperature activity/stability, a wide range of pH stabilities, and high proline specificity.	Proline	128-135	prolyl endopeptidase	Homo sapiens	41-44
32457723-7	2020	Rv1768 binds S100A9 with the proline-glutamic acid domain (PE domain) and blocks the interaction between S100A9 and Toll-like receptor 4 (TLR4), and suppresses TLR4-myeloid differentiation factor 88-nuclear factor-kappa B (NF-kappaB)-tumor necrosis factor alpha (TNF-alpha) signaling in macrophages.	Proline	29-36	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	13-19
32286796-1	2020	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine (ser)/threonine (Thr) kinase that has been demonstrated to be one of the most diversely functional kinases within neurons.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
32286796-1	2020	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine (ser)/threonine (Thr) kinase that has been demonstrated to be one of the most diversely functional kinases within neurons.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
32139596-5	2020	Specifically, we find that proinsulin Tyr-B16, which is a key residue in normal proinsulin dimerization, helps confer dominant-negative behavior of MIDY mutant proinsulin-C(A7)Y. Substitutions of Tyr-B16 with ether Ala, Asp, or Pro in proinsulin-C(A7)Y each decrease the abnormal interactions between the MIDY mutant and proinsulin-WT, rescuing proinsulin-WT export, limiting ER stress, and increasing insulin production in beta-cells and human islets.	Proline	228-231	insulin	Homo sapiens	27-37
32126198-6	2020	We identify disinhibition of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a negative PI3K regulator that tau controls, as a plausible mechanism and demonstrate that tau interacts with PTEN via tau"s proline-rich domain.	Proline	218-225	phosphatase and tensin homolog	Mus musculus	86-90
32126198-6	2020	We identify disinhibition of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a negative PI3K regulator that tau controls, as a plausible mechanism and demonstrate that tau interacts with PTEN via tau"s proline-rich domain.	Proline	218-225	microtubule associated protein tau	Homo sapiens	184-187
32126198-6	2020	We identify disinhibition of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a negative PI3K regulator that tau controls, as a plausible mechanism and demonstrate that tau interacts with PTEN via tau"s proline-rich domain.	Proline	218-225	phosphatase and tensin homolog	Mus musculus	203-207
32126198-6	2020	We identify disinhibition of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a negative PI3K regulator that tau controls, as a plausible mechanism and demonstrate that tau interacts with PTEN via tau"s proline-rich domain.	Proline	218-225	microtubule associated protein tau	Homo sapiens	184-187
32365082-0	2020	Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination.	Proline	41-48	CD8a molecule	Homo sapiens	17-20
32365082-2	2020	Here, we demonstrate that CD8+ T cell recognition of the naturally occurring MHC-I-restricted LCMV-associated immune escape variant Y4F is restored following vaccination with a proline-altered peptide ligand (APL).	Proline	177-184	CD8a molecule	Homo sapiens	26-29
32426354-4	2020	Pin1, a key PPIase in the cell, recognizes a phosphorylated Ser/Thr-Pro motif to catalyze peptidyl-prolyl isomerization in proteins.	Proline	68-71	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
32161166-2	2020	Previous studies have defined two subgroups of HLA-B*51 peptidome containing Proline (Pro) or Alanine (Ala) at position 2 (P2).	Proline	77-84	major histocompatibility complex, class I, B	Homo sapiens	47-52
32161166-2	2020	Previous studies have defined two subgroups of HLA-B*51 peptidome containing Proline (Pro) or Alanine (Ala) at position 2 (P2).	Proline	77-80	major histocompatibility complex, class I, B	Homo sapiens	47-52
32161166-10	2020	More than 20% of peptides eluted from HLA-B*51:01 lacked Proline or Alanine at P2.	Proline	57-64	major histocompatibility complex, class I, B	Homo sapiens	38-43
32332923-4	2020	We identified the splicing factor proline and glutamine rich (SFPQ) as a critical mediator of response to PT in an unbiased functional genomic screening in EOC cells and, using a large cohort of primary and recurrent EOC samples, we observed that it is frequently overexpressed in recurrent PT-treated samples and that its overexpression correlates with PT resistance.	Proline	34-41	splicing factor proline and glutamine rich	Homo sapiens	62-66
32202265-7	2020	Based on the in vitro studies, the improvement of proline levels is probably due to the induced expression of SLC6A20 and SLC38A2.	Proline	50-57	solute carrier family 6 member 20	Homo sapiens	110-117
32202265-7	2020	Based on the in vitro studies, the improvement of proline levels is probably due to the induced expression of SLC6A20 and SLC38A2.	Proline	50-57	solute carrier family 38 member 2	Homo sapiens	122-129
32161166-12	2020	Knockdown of ERAP1 increased the percentage of non-Pro/Ala2 from 20% to approximately 40%, increased the percentage of longer (10-mer and 11-mer) peptides eluted from HLA-B*51:01 complexes, and abrogated the predominance of Leucine at P1.	Proline	51-54	endoplasmic reticulum aminopeptidase 1	Homo sapiens	13-18
32426354-4	2020	Pin1, a key PPIase in the cell, recognizes a phosphorylated Ser/Thr-Pro motif to catalyze peptidyl-prolyl isomerization in proteins.	Proline	68-71	peptidylprolyl isomerase like 1	Homo sapiens	12-18
32411186-0	2020	Proline Homeostasis in Saccharomyces cerevisiae: How Does the Stress-Responsive Transcription Factor Msn2 Play a Role?	Proline	0-7	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	101-105
32266815-3	2020	Here, we apply site-specific isotopic labeling to obtain high-resolution NMR data on the cis/trans equilibrium of prolines within the poly-P repeats of huntingtin exon 1, the causative agent of Huntington"s disease.	Proline	114-122	huntingtin	Homo sapiens	152-162
32411186-2	2020	Recent studies have found that the Msn2 is a feasible potential mediator of proline homeostasis in yeast.	Proline	76-83	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	35-39
32411186-4	2020	Increased understanding of the cellular responses induced by the Msn2-mediated proline incorporation will provide better comprehension of how cells respond to and counteract to different kinds of stimuli and will also contribute to the breeding of industrial yeast strains with increased productivity.	Proline	79-86	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	65-69
32349679-8	2020	Protein-protein interactions supported their role in proline biosynthesis through interactions with genes, such as delta 1-pyrroline-5-carboxylate synthetase (P5CS) and pyrroline-5-carboxylate reductase (P5CR), involved in the proline metabolic pathway.	Proline	53-60	delta-1-pyrroline-5-carboxylate synthase 1	Triticum aestivum	115-157
32349679-8	2020	Protein-protein interactions supported their role in proline biosynthesis through interactions with genes, such as delta 1-pyrroline-5-carboxylate synthetase (P5CS) and pyrroline-5-carboxylate reductase (P5CR), involved in the proline metabolic pathway.	Proline	53-60	pyrroline-5-carboxylate reductase	Triticum aestivum	169-202
32349679-8	2020	Protein-protein interactions supported their role in proline biosynthesis through interactions with genes, such as delta 1-pyrroline-5-carboxylate synthetase (P5CS) and pyrroline-5-carboxylate reductase (P5CR), involved in the proline metabolic pathway.	Proline	53-60	pyrroline-5-carboxylate reductase	Triticum aestivum	204-208
32349679-8	2020	Protein-protein interactions supported their role in proline biosynthesis through interactions with genes, such as delta 1-pyrroline-5-carboxylate synthetase (P5CS) and pyrroline-5-carboxylate reductase (P5CR), involved in the proline metabolic pathway.	Proline	227-234	delta-1-pyrroline-5-carboxylate synthase 1	Triticum aestivum	115-157
32349679-8	2020	Protein-protein interactions supported their role in proline biosynthesis through interactions with genes, such as delta 1-pyrroline-5-carboxylate synthetase (P5CS) and pyrroline-5-carboxylate reductase (P5CR), involved in the proline metabolic pathway.	Proline	227-234	pyrroline-5-carboxylate reductase	Triticum aestivum	169-202
32336957-5	2020	The results revealed that the identified ORF1ab polyprotein belongs to a part of nonstructural protein 1 (nsp1) with the high antigenicity residues in a glycine-proline or hydrophobic amino acid rich domain.	Proline	161-168	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	41-59
32336957-5	2020	The results revealed that the identified ORF1ab polyprotein belongs to a part of nonstructural protein 1 (nsp1) with the high antigenicity residues in a glycine-proline or hydrophobic amino acid rich domain.	Proline	161-168	SH2 domain containing 3A	Homo sapiens	106-110
32122972-4	2020	We observed that mechanical stretch increased IKv1.5, and this increase required the intact long, proline-rich extracellular S1-S2 linker of the Kv1.5 channel.	Proline	98-105	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	47-52
32315321-1	2020	The proline-specific enzymes dipeptidyl peptidase 4 (DPP4), prolylcarboxypeptidase (PRCP), fibroblast activation protein alpha (FAP) and prolyl oligopeptidase (PREP) are known for their involvement in the immune system and blood pressure regulation.	Proline	4-11	dipeptidyl peptidase 4	Homo sapiens	29-51
32315321-1	2020	The proline-specific enzymes dipeptidyl peptidase 4 (DPP4), prolylcarboxypeptidase (PRCP), fibroblast activation protein alpha (FAP) and prolyl oligopeptidase (PREP) are known for their involvement in the immune system and blood pressure regulation.	Proline	4-11	dipeptidyl peptidase 4	Homo sapiens	53-57
32315321-1	2020	The proline-specific enzymes dipeptidyl peptidase 4 (DPP4), prolylcarboxypeptidase (PRCP), fibroblast activation protein alpha (FAP) and prolyl oligopeptidase (PREP) are known for their involvement in the immune system and blood pressure regulation.	Proline	4-11	fibroblast activation protein alpha	Homo sapiens	91-126
32315321-1	2020	The proline-specific enzymes dipeptidyl peptidase 4 (DPP4), prolylcarboxypeptidase (PRCP), fibroblast activation protein alpha (FAP) and prolyl oligopeptidase (PREP) are known for their involvement in the immune system and blood pressure regulation.	Proline	4-11	prolyl endopeptidase	Homo sapiens	137-158
32315321-1	2020	The proline-specific enzymes dipeptidyl peptidase 4 (DPP4), prolylcarboxypeptidase (PRCP), fibroblast activation protein alpha (FAP) and prolyl oligopeptidase (PREP) are known for their involvement in the immune system and blood pressure regulation.	Proline	4-11	prolyl endopeptidase	Homo sapiens	160-164
32134147-0	2020	Proline biosynthesis is a vent for TGFbeta-induced mitochondrial redox stress.	Proline	0-7	transforming growth factor alpha	Homo sapiens	35-42
32134147-4	2020	Surprisingly, we found that in addition to stimulating the entry of glucose and glutamine carbon into the TCA cycle, TGFbeta induced the biosynthesis of proline from glutamine in a Smad4-dependent fashion.	Proline	153-160	transforming growth factor alpha	Homo sapiens	117-124
32134147-4	2020	Surprisingly, we found that in addition to stimulating the entry of glucose and glutamine carbon into the TCA cycle, TGFbeta induced the biosynthesis of proline from glutamine in a Smad4-dependent fashion.	Proline	153-160	SMAD family member 4	Homo sapiens	181-186
32134147-6	2020	Thus, proline biosynthesis acts as a redox vent, preventing the TGFbeta-induced increase in mitochondrial glucose and glutamine catabolism from generating damaging reactive oxygen species (ROS) when TCA cycle activity exceeds the ability of oxidative phosphorylation to convert mitochondrial redox potential into ATP.	Proline	6-13	transforming growth factor alpha	Homo sapiens	64-71
32134147-7	2020	In turn, the enhanced synthesis of proline supports TGFbeta-induced production of matrix proteins.	Proline	35-42	transforming growth factor alpha	Homo sapiens	52-59
32213586-2	2020	Particularly, proline metabolism is critical for tumorigenesis since pyrroline-5-carboxylate (P5C) reductase (PYCR/P5CR) is highly expressed in various tumors and its enzymatic activity is essential for in vitro 3D tumor cell growth and in vivo tumorigenesis.	Proline	14-21	pyrroline-5-carboxylate reductase 1	Homo sapiens	69-92
32213586-2	2020	Particularly, proline metabolism is critical for tumorigenesis since pyrroline-5-carboxylate (P5C) reductase (PYCR/P5CR) is highly expressed in various tumors and its enzymatic activity is essential for in vitro 3D tumor cell growth and in vivo tumorigenesis.	Proline	14-21	pyrroline-5-carboxylate reductase 1	Homo sapiens	94-97
32213586-2	2020	Particularly, proline metabolism is critical for tumorigenesis since pyrroline-5-carboxylate (P5C) reductase (PYCR/P5CR) is highly expressed in various tumors and its enzymatic activity is essential for in vitro 3D tumor cell growth and in vivo tumorigenesis.	Proline	14-21	pyrroline-5-carboxylate reductase 1	Homo sapiens	110-114
32213586-2	2020	Particularly, proline metabolism is critical for tumorigenesis since pyrroline-5-carboxylate (P5C) reductase (PYCR/P5CR) is highly expressed in various tumors and its enzymatic activity is essential for in vitro 3D tumor cell growth and in vivo tumorigenesis.	Proline	14-21	pyrroline-5-carboxylate reductase 1	Homo sapiens	115-119
32213586-3	2020	PYCR converts the P5C intermediate to proline as a biosynthesis pathway, whereas proline dehydrogenase (PRODH) breaks down proline to P5C as a degradation pathway.	Proline	38-45	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-4
32159324-1	2020	Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent 2-electron oxidation of l-proline to Delta1-pyrroline-5-carboxylate.	Proline	58-65	proline dehydrogenase 1	Homo sapiens	0-21
32159324-1	2020	Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent 2-electron oxidation of l-proline to Delta1-pyrroline-5-carboxylate.	Proline	58-65	proline dehydrogenase 1	Homo sapiens	23-28
32159324-1	2020	Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent 2-electron oxidation of l-proline to Delta1-pyrroline-5-carboxylate.	Proline	120-129	proline dehydrogenase 1	Homo sapiens	0-21
32159324-1	2020	Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent 2-electron oxidation of l-proline to Delta1-pyrroline-5-carboxylate.	Proline	120-129	proline dehydrogenase 1	Homo sapiens	23-28
32159324-3	2020	Here we show that the proline analogue thiazolidine-2-carboxylate (T2C) is a mechanism-based inactivator of PRODH.	Proline	22-29	proline dehydrogenase 1	Homo sapiens	108-113
32159324-4	2020	Structures of the bifunctional proline catabolic enzyme proline utilization A (PutA) determined from crystals grown in the presence of T2C feature strong electron density for a 5-membered ring species resembling l-T2C covalently bound to the N5 of the FAD in the PRODH domain.	Proline	31-38	proline dehydrogenase 1	Homo sapiens	263-268
32159324-4	2020	Structures of the bifunctional proline catabolic enzyme proline utilization A (PutA) determined from crystals grown in the presence of T2C feature strong electron density for a 5-membered ring species resembling l-T2C covalently bound to the N5 of the FAD in the PRODH domain.	Proline	56-63	proline dehydrogenase 1	Homo sapiens	263-268
32159324-10	2020	These results may inform the design of new mechanism-based inactivators of PRODH for use as chemical probes to study the roles of proline metabolism in cancer.	Proline	130-137	proline dehydrogenase 1	Homo sapiens	75-80
32202299-2	2020	beta-Amino acid substitution at the proline residue of Ang III (beta-Pro7-Ang III) resulted in a highly selective AT2R ligand, demonstrating remarkable selectivity for the AT2R in both binding and functional studies.	Proline	36-43	angiotensin II receptor, type 2	Rattus norvegicus	114-118
32316396-7	2020	KEGG and pathway enrichment analyses of those urinary metabolites, and the Person"s correlation analyses among those urinary metabolites and bone status revealed that LF impacted on bone formation via regulatory comprehensive pathways including taurine and hypotaurine metabolism, arginine and proline metabolism, cyanoamino acid metabolism, nitrogen metabolism, nicotinate and nicotinamide metabolism, and fatty acid biosynthesis.	Proline	294-301	lactotransferrin	Rattus norvegicus	167-169
32014252-4	2020	Two new blaNDM-1 alleles that have polymorphisms in the signal peptide; NDM-1(P9R), a proline to arginine substitution, and NDM-2, a proline to alanine substitution (P28A) were studied.	Proline	86-93	NDM-1 metallo-beta-lactamase	Escherichia coli	8-16
32014252-4	2020	Two new blaNDM-1 alleles that have polymorphisms in the signal peptide; NDM-1(P9R), a proline to arginine substitution, and NDM-2, a proline to alanine substitution (P28A) were studied.	Proline	86-93	Beta-lactamase	Escherichia coli	11-16
32014252-4	2020	Two new blaNDM-1 alleles that have polymorphisms in the signal peptide; NDM-1(P9R), a proline to arginine substitution, and NDM-2, a proline to alanine substitution (P28A) were studied.	Proline	133-140	NDM-1 metallo-beta-lactamase	Escherichia coli	8-16
32014252-4	2020	Two new blaNDM-1 alleles that have polymorphisms in the signal peptide; NDM-1(P9R), a proline to arginine substitution, and NDM-2, a proline to alanine substitution (P28A) were studied.	Proline	133-140	Beta-lactamase	Escherichia coli	11-16
32213586-3	2020	PYCR converts the P5C intermediate to proline as a biosynthesis pathway, whereas proline dehydrogenase (PRODH) breaks down proline to P5C as a degradation pathway.	Proline	81-88	proline dehydrogenase 1	Homo sapiens	104-109
32213586-3	2020	PYCR converts the P5C intermediate to proline as a biosynthesis pathway, whereas proline dehydrogenase (PRODH) breaks down proline to P5C as a degradation pathway.	Proline	81-88	pyrroline-5-carboxylate reductase 1	Homo sapiens	134-137
32213586-4	2020	Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth.	Proline	29-36	pyrroline-5-carboxylate reductase 1	Homo sapiens	50-54
32213586-4	2020	Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth.	Proline	29-36	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	124-129
32213586-4	2020	Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth.	Proline	29-36	tumor protein p53	Homo sapiens	146-149
32213586-4	2020	Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth.	Proline	29-36	pyrroline-5-carboxylate reductase 1	Homo sapiens	210-213
32213586-4	2020	Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth.	Proline	64-71	proline dehydrogenase 1	Homo sapiens	84-89
32213586-4	2020	Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth.	Proline	64-71	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	124-129
32213586-4	2020	Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth.	Proline	64-71	tumor protein p53	Homo sapiens	146-149
32213586-4	2020	Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth.	Proline	64-71	pyrroline-5-carboxylate reductase 1	Homo sapiens	210-213
32213586-4	2020	Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth.	Proline	64-71	proline dehydrogenase 1	Homo sapiens	84-89
32213586-4	2020	Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth.	Proline	64-71	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	124-129
32213586-4	2020	Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth.	Proline	64-71	tumor protein p53	Homo sapiens	146-149
32213586-4	2020	Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth.	Proline	64-71	pyrroline-5-carboxylate reductase 1	Homo sapiens	210-213
32213586-7	2020	Strikingly, the KSHV K1 oncoprotein interacted with and activated PYCR enzyme, increasing intracellular proline concentration.	Proline	104-111	pyrroline-5-carboxylate reductase 1	Homo sapiens	66-70
32213586-10	2020	This study demonstrates that an increase of proline biosynthesis induced by K1-PYCR interaction is critical for KSHV-mediated transformation in in vitro 3D culture condition and in vivo tumorigenesis.	Proline	44-51	K1	Human gammaherpesvirus 8	76-83
32234471-1	2020	Translation of consecutive proline motifs causes ribosome stalling and requires rescue via the action of a specific translation elongation factor, EF-P in bacteria and archaeal/eukaryotic a/eIF5A.	Proline	27-34	eukaryotic translation initiation factor 5A	Homo sapiens	190-195
32300594-2	2020	Following signaling events that mediate phosphorylation of MYC at Serine 62, PIN1 establishes structurally distinct pools of MYC through its trans-cis and cis-trans isomerization activity at Proline 63.	Proline	191-198	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	59-62
32300594-2	2020	Following signaling events that mediate phosphorylation of MYC at Serine 62, PIN1 establishes structurally distinct pools of MYC through its trans-cis and cis-trans isomerization activity at Proline 63.	Proline	191-198	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	77-81
32170468-8	2020	Conversely, proline supplementation resulted in higher (P < 0.05) concentrations of (1) IL-10, IL-17 and granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma; (2) IL-10 and IL-1alpha in the uterus; and (3) IL-1alpha, IL-1beta, IL-10, IL-27, and IFN-beta in amniotic fluid, compared with controls.	Proline	12-19	interferon alpha	Mus musculus	260-268
32170468-9	2020	Moreover, concentrations of immunoglobulin (Ig) G2b and IgM were enhanced (P < 0.05) by proline administration.	Proline	88-95	immunoglobulin heavy constant gamma 2B	Mus musculus	28-51
32197005-8	2020	Additionally, we detected the role of leucine proline-enriched proteoglycan 1 knockdown on PI3K/AKT pathway-related proteins using western blotting.	Proline	46-53	AKT serine/threonine kinase 1	Homo sapiens	96-99
32197005-12	2020	Furthermore, the expression of phosphorylated PI3K and AKT was impaired after knockdown the leucine proline-enriched proteoglycan 1 as well as P70S6K.	Proline	100-107	AKT serine/threonine kinase 1	Homo sapiens	55-58
32197005-13	2020	In conclusion, leucine proline-enriched proteoglycan 1 might function as an important therapeutic factor in human osteosarcoma through regulating the PI3K/AKT signaling pathway.	Proline	23-30	AKT serine/threonine kinase 1	Homo sapiens	155-158
32037484-1	2020	Proline-, glutamic acid-, leucine-rich protein 1 (PELP1) is a novel estrogen receptor (ER) coregulator, demonstrated distinctive characters from other ERalpha coregulators, and has been suggested to be involved in metastasis of several cancers.	Proline	0-7	proline, glutamate and leucine rich protein 1	Homo sapiens	50-55
32037484-1	2020	Proline-, glutamic acid-, leucine-rich protein 1 (PELP1) is a novel estrogen receptor (ER) coregulator, demonstrated distinctive characters from other ERalpha coregulators, and has been suggested to be involved in metastasis of several cancers.	Proline	0-7	estrogen receptor 1	Homo sapiens	151-158
32112235-4	2020	The time course effects of the applications showed that exogenous proline significantly enhanced PSII efficiency, PEPc activity, rubisco activity, and the relative expression levels of PEPc, rubisco large subunit, rubisco small subunit, and RCA genes at 0, 4, and 8 h. The W23/M14 genotype had higher rubisco quantity than the Safak genotype at all time periods.	Proline	66-73	MLO-like protein 4	Zea mays	114-118
32112235-4	2020	The time course effects of the applications showed that exogenous proline significantly enhanced PSII efficiency, PEPc activity, rubisco activity, and the relative expression levels of PEPc, rubisco large subunit, rubisco small subunit, and RCA genes at 0, 4, and 8 h. The W23/M14 genotype had higher rubisco quantity than the Safak genotype at all time periods.	Proline	66-73	MLO-like protein 4	Zea mays	185-189
32170468-5	2020	The data showed that proline supplementation led to higher (P < 0.05) populations of B lymphocytes (CD3-CD19+), natural killer (NK) cells (CD3-NK1.1+), and dendritic cells (DCs, CD11c+MHCII+) in peripheral blood, as compared with the controls.	Proline	21-28	CD3 antigen, epsilon polypeptide	Mus musculus	100-103
32170468-5	2020	The data showed that proline supplementation led to higher (P < 0.05) populations of B lymphocytes (CD3-CD19+), natural killer (NK) cells (CD3-NK1.1+), and dendritic cells (DCs, CD11c+MHCII+) in peripheral blood, as compared with the controls.	Proline	21-28	CD3 antigen, epsilon polypeptide	Mus musculus	139-142
32170468-5	2020	The data showed that proline supplementation led to higher (P < 0.05) populations of B lymphocytes (CD3-CD19+), natural killer (NK) cells (CD3-NK1.1+), and dendritic cells (DCs, CD11c+MHCII+) in peripheral blood, as compared with the controls.	Proline	21-28	integrin alpha X	Mus musculus	178-183
32170468-6	2020	Conversely, mice fed a proline-supplemented diet had a lower population of neutrophils (CD11b+F4/80-).	Proline	23-30	integrin alpha M	Mus musculus	88-93
32170468-6	2020	Conversely, mice fed a proline-supplemented diet had a lower population of neutrophils (CD11b+F4/80-).	Proline	23-30	adhesion G protein-coupled receptor E1	Mus musculus	94-101
32170468-7	2020	Further study showed that proline supplementation decreased (P < 0.05) the concentrations of (1) interleukin (IL)-23, IL-1alpha, and IL-6 in plasma; (2) IL-6 in the uterus; and (3) tumor necrosis factor alpha (TNF-alpha), monocyte chemotactic protein (MCP)-1, and IL-17 in the placenta; and (4) interferon (IFN)-gamma in amniotic fluid, compared with controls.	Proline	26-33	interleukin 1 alpha	Mus musculus	118-127
32170468-7	2020	Further study showed that proline supplementation decreased (P < 0.05) the concentrations of (1) interleukin (IL)-23, IL-1alpha, and IL-6 in plasma; (2) IL-6 in the uterus; and (3) tumor necrosis factor alpha (TNF-alpha), monocyte chemotactic protein (MCP)-1, and IL-17 in the placenta; and (4) interferon (IFN)-gamma in amniotic fluid, compared with controls.	Proline	26-33	interleukin 6	Mus musculus	133-137
32170468-7	2020	Further study showed that proline supplementation decreased (P < 0.05) the concentrations of (1) interleukin (IL)-23, IL-1alpha, and IL-6 in plasma; (2) IL-6 in the uterus; and (3) tumor necrosis factor alpha (TNF-alpha), monocyte chemotactic protein (MCP)-1, and IL-17 in the placenta; and (4) interferon (IFN)-gamma in amniotic fluid, compared with controls.	Proline	26-33	interleukin 6	Mus musculus	153-157
32170468-7	2020	Further study showed that proline supplementation decreased (P < 0.05) the concentrations of (1) interleukin (IL)-23, IL-1alpha, and IL-6 in plasma; (2) IL-6 in the uterus; and (3) tumor necrosis factor alpha (TNF-alpha), monocyte chemotactic protein (MCP)-1, and IL-17 in the placenta; and (4) interferon (IFN)-gamma in amniotic fluid, compared with controls.	Proline	26-33	tumor necrosis factor	Mus musculus	181-208
32170468-7	2020	Further study showed that proline supplementation decreased (P < 0.05) the concentrations of (1) interleukin (IL)-23, IL-1alpha, and IL-6 in plasma; (2) IL-6 in the uterus; and (3) tumor necrosis factor alpha (TNF-alpha), monocyte chemotactic protein (MCP)-1, and IL-17 in the placenta; and (4) interferon (IFN)-gamma in amniotic fluid, compared with controls.	Proline	26-33	tumor necrosis factor	Mus musculus	210-219
32170468-7	2020	Further study showed that proline supplementation decreased (P < 0.05) the concentrations of (1) interleukin (IL)-23, IL-1alpha, and IL-6 in plasma; (2) IL-6 in the uterus; and (3) tumor necrosis factor alpha (TNF-alpha), monocyte chemotactic protein (MCP)-1, and IL-17 in the placenta; and (4) interferon (IFN)-gamma in amniotic fluid, compared with controls.	Proline	26-33	chemokine (C-C motif) ligand 2	Mus musculus	222-258
32170468-7	2020	Further study showed that proline supplementation decreased (P < 0.05) the concentrations of (1) interleukin (IL)-23, IL-1alpha, and IL-6 in plasma; (2) IL-6 in the uterus; and (3) tumor necrosis factor alpha (TNF-alpha), monocyte chemotactic protein (MCP)-1, and IL-17 in the placenta; and (4) interferon (IFN)-gamma in amniotic fluid, compared with controls.	Proline	26-33	interleukin 17A	Mus musculus	264-269
32170468-8	2020	Conversely, proline supplementation resulted in higher (P < 0.05) concentrations of (1) IL-10, IL-17 and granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma; (2) IL-10 and IL-1alpha in the uterus; and (3) IL-1alpha, IL-1beta, IL-10, IL-27, and IFN-beta in amniotic fluid, compared with controls.	Proline	12-19	interleukin 10	Mus musculus	88-93
32170468-8	2020	Conversely, proline supplementation resulted in higher (P < 0.05) concentrations of (1) IL-10, IL-17 and granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma; (2) IL-10 and IL-1alpha in the uterus; and (3) IL-1alpha, IL-1beta, IL-10, IL-27, and IFN-beta in amniotic fluid, compared with controls.	Proline	12-19	interleukin 17A	Mus musculus	95-100
32170468-8	2020	Conversely, proline supplementation resulted in higher (P < 0.05) concentrations of (1) IL-10, IL-17 and granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma; (2) IL-10 and IL-1alpha in the uterus; and (3) IL-1alpha, IL-1beta, IL-10, IL-27, and IFN-beta in amniotic fluid, compared with controls.	Proline	12-19	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	105-153
32170468-8	2020	Conversely, proline supplementation resulted in higher (P < 0.05) concentrations of (1) IL-10, IL-17 and granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma; (2) IL-10 and IL-1alpha in the uterus; and (3) IL-1alpha, IL-1beta, IL-10, IL-27, and IFN-beta in amniotic fluid, compared with controls.	Proline	12-19	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	155-161
32170468-8	2020	Conversely, proline supplementation resulted in higher (P < 0.05) concentrations of (1) IL-10, IL-17 and granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma; (2) IL-10 and IL-1alpha in the uterus; and (3) IL-1alpha, IL-1beta, IL-10, IL-27, and IFN-beta in amniotic fluid, compared with controls.	Proline	12-19	interleukin 10	Mus musculus	178-183
32170468-8	2020	Conversely, proline supplementation resulted in higher (P < 0.05) concentrations of (1) IL-10, IL-17 and granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma; (2) IL-10 and IL-1alpha in the uterus; and (3) IL-1alpha, IL-1beta, IL-10, IL-27, and IFN-beta in amniotic fluid, compared with controls.	Proline	12-19	interleukin 1 alpha	Mus musculus	188-197
32170468-8	2020	Conversely, proline supplementation resulted in higher (P < 0.05) concentrations of (1) IL-10, IL-17 and granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma; (2) IL-10 and IL-1alpha in the uterus; and (3) IL-1alpha, IL-1beta, IL-10, IL-27, and IFN-beta in amniotic fluid, compared with controls.	Proline	12-19	interleukin 1 alpha	Mus musculus	221-230
32170468-8	2020	Conversely, proline supplementation resulted in higher (P < 0.05) concentrations of (1) IL-10, IL-17 and granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma; (2) IL-10 and IL-1alpha in the uterus; and (3) IL-1alpha, IL-1beta, IL-10, IL-27, and IFN-beta in amniotic fluid, compared with controls.	Proline	12-19	interleukin 1 alpha	Mus musculus	232-240
32170468-8	2020	Conversely, proline supplementation resulted in higher (P < 0.05) concentrations of (1) IL-10, IL-17 and granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma; (2) IL-10 and IL-1alpha in the uterus; and (3) IL-1alpha, IL-1beta, IL-10, IL-27, and IFN-beta in amniotic fluid, compared with controls.	Proline	12-19	interleukin 10	Mus musculus	178-183
32170468-8	2020	Conversely, proline supplementation resulted in higher (P < 0.05) concentrations of (1) IL-10, IL-17 and granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma; (2) IL-10 and IL-1alpha in the uterus; and (3) IL-1alpha, IL-1beta, IL-10, IL-27, and IFN-beta in amniotic fluid, compared with controls.	Proline	12-19	interleukin 27	Mus musculus	249-254
32474547-6	2020	However, among the XDR-TB isolates (n = 4), one specimen (25%) was found to be associated with a mutation in atpE gene at position 49, resulting in the amino acid leucine replaced by proline (L-49-P).	Proline	183-190	ATP synthase F1 subunit epsilon	Homo sapiens	109-113
32036086-2	2020	This mutated allele encodes a truncated form of the receptor (p.P2514Rfs*4) lacking the C-terminal proline, glutamic acid, serine, and threonine (PEST) degradation domain that increases NOTCH1 signaling duration.	Proline	99-106	notch receptor 1	Homo sapiens	186-192
32296699-1	2020	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is an evolutionally conserved and unique enzyme that specifically catalyzes the cis-trans isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif and, subsequently, induces the conformational change of its substrates.	Proline	201-208	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-54
32296699-1	2020	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is an evolutionally conserved and unique enzyme that specifically catalyzes the cis-trans isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif and, subsequently, induces the conformational change of its substrates.	Proline	201-208	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	56-60
32218435-3	2020	We show that activity-induced Kv4.2 phosphorylation triggers Pin1 binding to, and isomerization of, Kv4.2 at the pThr607-Pro motif, leading to the dissociation of the Kv4.2-DPP6 complex.	Proline	121-124	potassium voltage-gated channel, Shal-related family, member 2	Mus musculus	30-35
32298235-6	2020	Additional factors that contribute to the control of the elongation rate include epigenetic modification of the mRNA, coding sequence variation and the expression of eIF5A, which stimulates peptide bond formation between proline residues.	Proline	221-228	eukaryotic translation initiation factor 5A	Homo sapiens	166-171
32218435-3	2020	We show that activity-induced Kv4.2 phosphorylation triggers Pin1 binding to, and isomerization of, Kv4.2 at the pThr607-Pro motif, leading to the dissociation of the Kv4.2-DPP6 complex.	Proline	121-124	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	61-65
32218435-3	2020	We show that activity-induced Kv4.2 phosphorylation triggers Pin1 binding to, and isomerization of, Kv4.2 at the pThr607-Pro motif, leading to the dissociation of the Kv4.2-DPP6 complex.	Proline	121-124	potassium voltage-gated channel, Shal-related family, member 2	Mus musculus	100-105
32218435-3	2020	We show that activity-induced Kv4.2 phosphorylation triggers Pin1 binding to, and isomerization of, Kv4.2 at the pThr607-Pro motif, leading to the dissociation of the Kv4.2-DPP6 complex.	Proline	121-124	dipeptidylpeptidase 6	Mus musculus	173-177
32317150-8	2020	Our work links CTPS with P5CS, two enzymes involved in the rate-limiting steps in pyrimidine and proline biosynthesis, respectively.	Proline	97-104	CTP synthase	Drosophila melanogaster	15-19
32280690-5	2020	Additionally, the serum ANGPTL4 levels in the HL-Pro group were significantly lower than those in the HL-NPro group (53.32 +- 24.01 ng/ml) (P < 0.001).	Proline	49-52	angiopoietin like 4	Homo sapiens	24-31
32280690-6	2020	The urine ANGPTL4/Cr levels in the HL-Pro group (52.01 (45.25, 79.79) mug/g) were significantly higher than those in the HL-NPro group (9.96 (8.35, 12.43) ng/ml) (P < 0.05).	Proline	38-41	angiopoietin like 4	Homo sapiens	10-17
32266261-1	2020	Pin1 is a peptidyl-prolyl cis-trans isomerase that specifically binds to a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif and catalyzes the cis-trans isomerization of proline imidic peptide bond, resulting in conformational change of its substrates.	Proline	130-137	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
32266261-1	2020	Pin1 is a peptidyl-prolyl cis-trans isomerase that specifically binds to a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif and catalyzes the cis-trans isomerization of proline imidic peptide bond, resulting in conformational change of its substrates.	Proline	204-211	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
32258027-1	2020	Peptidyl-prolyl isomerase (PIN1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which results in the alteration of protein structure, function, and stability.	Proline	103-110	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	27-31
32023483-6	2020	SFMBT1 hydroxylation on Proline residue 651 by EglN1 mediated its ubiquitination and degradation governed by pVHL.	Proline	24-31	Scm like with four mbt domains 1	Homo sapiens	0-6
32023483-6	2020	SFMBT1 hydroxylation on Proline residue 651 by EglN1 mediated its ubiquitination and degradation governed by pVHL.	Proline	24-31	egl-9 family hypoxia inducible factor 1	Homo sapiens	47-52
32023483-6	2020	SFMBT1 hydroxylation on Proline residue 651 by EglN1 mediated its ubiquitination and degradation governed by pVHL.	Proline	24-31	von Hippel-Lindau tumor suppressor	Homo sapiens	109-113
32256312-6	2020	Most importantly, I show that proline-directed phosphorylation of the N-terminus domain of PSD-95 alters the local conformation of this region.	Proline	30-37	discs large MAGUK scaffold protein 4	Homo sapiens	91-97
32256312-7	2020	Therefore, proline-directed phosphorylation of the N-terminus of PSD-95, Pin1 association, and peptidyl-prolyl cis-trans isomerization may all play a role in excitatory synaptic function and synapse development.	Proline	11-18	discs large MAGUK scaffold protein 4	Homo sapiens	65-71
32256312-7	2020	Therefore, proline-directed phosphorylation of the N-terminus of PSD-95, Pin1 association, and peptidyl-prolyl cis-trans isomerization may all play a role in excitatory synaptic function and synapse development.	Proline	11-18	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	73-77
32187554-6	2020	Also, FKBP10 interacts with ribosomes, and its downregulation leads to reduction of translation elongation at the beginning of open reading frames (ORFs), particularly upon insertion of proline residues.	Proline	186-193	FK506 binding protein 10	Mus musculus	6-12
31855737-4	2020	Prolyl hydroxylase 2 (PHD2) predominantly hydroxylates proline residues in HIF-1alpha to promote its degradation.	Proline	55-62	egl-9 family hypoxia-inducible factor 1	Mus musculus	0-20
32109368-5	2020	Here, we show that the N-terminal proline remnant of the 2A peptide, alone or in combination with leucine, introduced during polycistronic cloning, destabilizes KLF4 resulting in increased protein degradation, which hinders reprogramming.	Proline	34-41	Kruppel like factor 4	Homo sapiens	161-165
32143681-6	2020	In contrast, the c.3629C > T variant caused a missense substitution of a proline with a leucine (p.P1210L) and produced a comparatively mild alteration of Cav3.2 channel activity.	Proline	73-80	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	155-161
32256584-6	2020	HIF-1 signaling pathway modulating P-glycoproteins expression, PI3K-Akt pathway regulating survivin expression, and oxidative phosphorylation were upregulated, while arginine and proline metabolism regulating NO production and glycolysis/gluconeogenesis were downregulated during osimertinib resistance.	Proline	179-186	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
32210831-9	2020	The L-Pro effect is dependent on mTORC1 signaling (rapamycin sensitive) while that for L-Gln is not.	Proline	5-9	CREB regulated transcription coactivator 1	Mus musculus	33-39
31855737-4	2020	Prolyl hydroxylase 2 (PHD2) predominantly hydroxylates proline residues in HIF-1alpha to promote its degradation.	Proline	55-62	egl-9 family hypoxia-inducible factor 1	Mus musculus	22-26
31855737-4	2020	Prolyl hydroxylase 2 (PHD2) predominantly hydroxylates proline residues in HIF-1alpha to promote its degradation.	Proline	55-62	hypoxia inducible factor 1, alpha subunit	Mus musculus	75-85
31933109-3	2020	They are substrates for production of pyrroline-5-carboxylate which is the product of conversion of proline by proline dehydrogenase/ proline oxidase (PRODH/POX) to produce ATP for protective autophagy or reactive oxygen species for apoptosis.	Proline	100-107	proline dehydrogenase 1	Homo sapiens	151-156
32309365-12	2020	Further mechanistic investigations indicated that the protective effect of PREP disruption on liver inflammation was associated with the suppressed production of matrix metalloproteinases (MMPs) and proline-glycine-proline (PGP) and the inhibition of neutrophil infiltration.	Proline	199-206	prolyl endopeptidase	Mus musculus	75-79
32309365-12	2020	Further mechanistic investigations indicated that the protective effect of PREP disruption on liver inflammation was associated with the suppressed production of matrix metalloproteinases (MMPs) and proline-glycine-proline (PGP) and the inhibition of neutrophil infiltration.	Proline	215-222	prolyl endopeptidase	Mus musculus	75-79
31960518-7	2020	We also found that enzymes that convert proline, valine, leucine, and isoleucine into glutamate were increased in IDH1 mut glioma.	Proline	40-47	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	114-118
31933109-3	2020	They are substrates for production of pyrroline-5-carboxylate which is the product of conversion of proline by proline dehydrogenase/ proline oxidase (PRODH/POX) to produce ATP for protective autophagy or reactive oxygen species for apoptosis.	Proline	100-107	proline dehydrogenase 1	Homo sapiens	157-160
31933109-4	2020	Interconversion of proline, ornithine, and glutamate may therefore regulate PRODH/POX-dependent apoptosis/autophagy.	Proline	19-26	proline dehydrogenase 1	Homo sapiens	76-81
31933109-4	2020	Interconversion of proline, ornithine, and glutamate may therefore regulate PRODH/POX-dependent apoptosis/autophagy.	Proline	19-26	proline dehydrogenase 1	Homo sapiens	82-85
31933109-9	2020	Proline availability for PRODH/POX-dependent apoptosis/autophagy is regulated at the level of collagen biosynthesis (proline utilizing process) and prolidase activity (proline supporting process).	Proline	0-7	proline dehydrogenase 1	Homo sapiens	25-30
31933109-9	2020	Proline availability for PRODH/POX-dependent apoptosis/autophagy is regulated at the level of collagen biosynthesis (proline utilizing process) and prolidase activity (proline supporting process).	Proline	0-7	proline dehydrogenase 1	Homo sapiens	31-34
31933109-9	2020	Proline availability for PRODH/POX-dependent apoptosis/autophagy is regulated at the level of collagen biosynthesis (proline utilizing process) and prolidase activity (proline supporting process).	Proline	0-7	peptidase D	Homo sapiens	148-157
31933109-9	2020	Proline availability for PRODH/POX-dependent apoptosis/autophagy is regulated at the level of collagen biosynthesis (proline utilizing process) and prolidase activity (proline supporting process).	Proline	117-124	proline dehydrogenase 1	Homo sapiens	25-30
31933109-9	2020	Proline availability for PRODH/POX-dependent apoptosis/autophagy is regulated at the level of collagen biosynthesis (proline utilizing process) and prolidase activity (proline supporting process).	Proline	117-124	proline dehydrogenase 1	Homo sapiens	31-34
31933109-9	2020	Proline availability for PRODH/POX-dependent apoptosis/autophagy is regulated at the level of collagen biosynthesis (proline utilizing process) and prolidase activity (proline supporting process).	Proline	168-175	proline dehydrogenase 1	Homo sapiens	25-30
31933109-9	2020	Proline availability for PRODH/POX-dependent apoptosis/autophagy is regulated at the level of collagen biosynthesis (proline utilizing process) and prolidase activity (proline supporting process).	Proline	168-175	proline dehydrogenase 1	Homo sapiens	31-34
32174040-4	2020	Phosphorylation assays with radioactively labelled ATP as well as ELISA-based experiments using a phospho-threonine-proline (pThr-Pro) antibody revealed, that CDK1-cyclin B specifically phosphorylates T131 , identifying TaSP as a substrate in vitro.	Proline	116-123	cyclin dependent kinase 1	Bos taurus	159-163
32046769-10	2020	In a LAT2 knock-out mouse model, CSF Gln was unchanged, whereas other amino acids normally 2-20-fold lower than in plasma, were increased, in particular the LAT2 uptake substrates leucine (Leu), valine (Val) and tryptophan (Trp) and some other amino acids such as glutamate (Glu), glycine (Gly) and proline (Pro).	Proline	299-306	linker for activation of T cells family, member 2	Mus musculus	157-161
31949048-6	2020	A helix-disrupting proline substitution within the putative alpha-helical motif in full-length PCSK9 lowered LDL binding affinity >5-fold.	Proline	19-26	proprotein convertase subtilisin/kexin type 9	Homo sapiens	95-100
33110735-7	2020	Normally, FUS localizes to the nucleus via the nuclear import receptor karyopherin beta2 (Kapbeta2) with the help of its C-terminal proline-tyrosine nuclear localization signal (PY-NLS).	Proline	132-139	FUS RNA binding protein	Homo sapiens	10-13
33110735-7	2020	Normally, FUS localizes to the nucleus via the nuclear import receptor karyopherin beta2 (Kapbeta2) with the help of its C-terminal proline-tyrosine nuclear localization signal (PY-NLS).	Proline	132-139	transportin 1	Homo sapiens	71-88
32027132-4	2020	Pramlintide, a synthetic peptide drug, and its natural counterpart rat amylin are known to be resistant to aggregation because of the presence of proline residues, which are usually beta-sheet "breakers" within their amino acid sequence.	Proline	146-153	islet amyloid polypeptide	Rattus norvegicus	71-77
32046769-10	2020	In a LAT2 knock-out mouse model, CSF Gln was unchanged, whereas other amino acids normally 2-20-fold lower than in plasma, were increased, in particular the LAT2 uptake substrates leucine (Leu), valine (Val) and tryptophan (Trp) and some other amino acids such as glutamate (Glu), glycine (Gly) and proline (Pro).	Proline	308-311	linker for activation of T cells family, member 2	Mus musculus	157-161
32500121-6	2020	We confirmed proline 216 in tau as critical for tau interaction with the BIN1-SH3 domain and show that phosphorylation of tau disrupts this binding, suggesting that tau phosphorylation in Alzheimer"s disease disrupts tau-BIN1 associations.	Proline	13-20	bridging integrator 1	Rattus norvegicus	73-77
31698056-3	2020	A variety of evidence indicates that Tau"s interactions with Fyn kinase and other SH3 domain-containing proteins, which bind to PxxP motifs in Tau"s proline-rich domain, may contribute to AD deficits and Abeta toxicity.	Proline	149-156	microtubule associated protein tau	Homo sapiens	143-146
31940485-4	2020	Here we show that the endocytic scaffold protein intersectin 1 clears release sites by direct SH3 domain-mediated association with a non-canonical proline-rich segment of synaptobrevin assembled into the SNARE complex for neuroexocytosis.	Proline	147-154	intersectin 1	Homo sapiens	49-62
31475386-2	2020	Here, we investigated the biologic effect of introducing a proline mutation in the beta2 integrin TMD to create a flexible kink that uncouples the topology of the inner half of the TMD from the outer half and impairs integrin activation.	Proline	59-66	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	83-88
31475386-6	2020	The proline mutation in the TMD of beta2 completely inhibited arrest of rolling HL-60 cells in response to the chemokine IL-8.	Proline	4-11	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	35-40
31475386-6	2020	The proline mutation in the TMD of beta2 completely inhibited arrest of rolling HL-60 cells in response to the chemokine IL-8.	Proline	4-11	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
31475386-10	2020	We conclude that the TMD proline mutation severely impairs beta2 integrin extension, cell arrest, and early spreading.	Proline	25-32	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	59-64
31698056-3	2020	A variety of evidence indicates that Tau"s interactions with Fyn kinase and other SH3 domain-containing proteins, which bind to PxxP motifs in Tau"s proline-rich domain, may contribute to AD deficits and Abeta toxicity.	Proline	149-156	microtubule associated protein tau	Homo sapiens	37-40
31418019-7	2020	We found that loss of the conserved proline-rich PPXXF sequence on DmGluRA reduces Homer/DmGluRA associations and significantly reduces sleep amount.	Proline	36-43	metabotropic Glutamate Receptor	Drosophila melanogaster	67-74
31418019-7	2020	We found that loss of the conserved proline-rich PPXXF sequence on DmGluRA reduces Homer/DmGluRA associations and significantly reduces sleep amount.	Proline	36-43	homer	Drosophila melanogaster	83-88
31418019-7	2020	We found that loss of the conserved proline-rich PPXXF sequence on DmGluRA reduces Homer/DmGluRA associations and significantly reduces sleep amount.	Proline	36-43	metabotropic Glutamate Receptor	Drosophila melanogaster	89-96
32500121-6	2020	We confirmed proline 216 in tau as critical for tau interaction with the BIN1-SH3 domain and show that phosphorylation of tau disrupts this binding, suggesting that tau phosphorylation in Alzheimer"s disease disrupts tau-BIN1 associations.	Proline	13-20	bridging integrator 1	Rattus norvegicus	221-225
31835299-10	2019	For osmotic adjustment, opr7opr8 produced less proline in the shoots at 100 and 300 mM NaCl treatments but more in the roots than the WT roots under all salt treatments.	Proline	47-54	12-oxophytodienoate reductase7	Zea mays	24-32
33554132-3	2020	BRPF1 contains a unique combination of chromatin reader domains including two plant homeodomain (PHD) fingers separated by a zinc knuckle (PZP domain), a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain.	Proline	173-180	bromodomain and PHD finger containing 1	Homo sapiens	0-5
33554132-3	2020	BRPF1 contains a unique combination of chromatin reader domains including two plant homeodomain (PHD) fingers separated by a zinc knuckle (PZP domain), a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain.	Proline	203-210	bromodomain and PHD finger containing 1	Homo sapiens	0-5
31697804-3	2019	Here, we describe a novel recurrent mutation characterized by a common 4-amino-acid deletion and variable 1-amino-acid insertion (Leu583-Ala586DelInsSer/Gln/Pro) within the JH2 domain of JAK2.	Proline	157-160	Janus kinase 2	Homo sapiens	187-191
31878075-0	2019	The Effect of Proline cis-trans Isomerization on the Folding of the C-Terminal SH2 Domain from p85.	Proline	14-21	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	95-98
31878075-4	2019	By comparing the kinetics of folding of the wild-type protein to that of a site-directed variant of C-SH2 in which the proline was replaced with an alanine, we demonstrate that this intermediate is dictated by the peptidyl prolyl cis-trans isomerization.	Proline	119-126	chorionic somatomammotropin hormone 2	Homo sapiens	100-105
31699899-0	2019	Independent tubulin binding and polymerization by the proline-rich region of Tau is regulated by Tau"s N-terminal domain.	Proline	54-61	microtubule associated protein tau	Homo sapiens	77-80
31699899-0	2019	Independent tubulin binding and polymerization by the proline-rich region of Tau is regulated by Tau"s N-terminal domain.	Proline	54-61	microtubule associated protein tau	Homo sapiens	97-100
31699899-3	2019	Here we used single-molecule fluorescence to investigate the role of Tau"s N-terminal domain (NTD) and proline-rich region (PRR) in regulating interactions of Tau with soluble tubulin.	Proline	103-110	microtubule associated protein tau	Homo sapiens	159-162
31711961-5	2019	We undertook a proline-scanning approach searching for regions in the syn1 6HB central helix that tolerate the introduction of helix-breaker residues and still fold correctly in the pre-fusion form.	Proline	15-22	synapsin I	Homo sapiens	70-74
31856055-9	2019	RESULTS: The 1336th nucleotide of MYH7 gene at exon 14 was converted from T to G in one HCM case, resulting in the conversion of threonine (Thr) at position 446 to proline (Pro).	Proline	164-171	myosin heavy chain 7	Homo sapiens	34-38
31856055-9	2019	RESULTS: The 1336th nucleotide of MYH7 gene at exon 14 was converted from T to G in one HCM case, resulting in the conversion of threonine (Thr) at position 446 to proline (Pro).	Proline	173-176	myosin heavy chain 7	Homo sapiens	34-38
30394205-1	2020	The prolyl isomerase Pin1 is a unique enzyme, which isomerizes the cis-trans conformation between pSer/pThr and proline and thereby regulates the function, stability and/or subcellular distribution of its target proteins.	Proline	112-119	parathyroid hormone 1 receptor	Mus musculus	103-107
31188489-2	2020	We created a mouse model of LMS (Notch3tm1.1Ecan ) by introducing a tandem termination codon in the Notch3 locus upstream of the proline (P), glutamic acid (E), serine (S) and threonine (T) domain.	Proline	129-136	notch 3	Mus musculus	100-106
31746393-9	2020	Serum levels of IL-37 were associated with the levels of IL-17, IL-6, and TNF-alpha, and clinical indexes such as the left ventricular ejection fraction (LVEF), amino-N-terminal pro-plasma brain natriuretic peptide (NT-proBNP) levels, and cardiac troponin T (cTnT) levels in CHD patients.	Proline	178-182	interleukin 37	Homo sapiens	16-21
31884946-1	2019	BACKGROUND: Hyperprolinemia type 2 (HPII) is a rare autosomal recessive disorder of the proline metabolism, that affects the ALDH4A1 gene.	Proline	17-24	aldehyde dehydrogenase 4 family member A1	Homo sapiens	125-132
31727740-7	2019	Structure-activity studies revealed that roseltide rT7 uses a canonical substrate-binding mechanism for proteasomal inhibition enabled by an IIML motif embedded in its proline-rich and exceptionally long intercysteine loop 4.	Proline	168-175	protein tyrosine phosphatase, receptor type, C	Rattus norvegicus	51-54
31282030-6	2019	While differences in the human and mouse exon 1 HTT proteins (e.g., proline rich sequences) could also contribute to the phenotypic differences, our data indicate that the incomplete splicing of HTT and approaches to lower the levels of the exon 1 HTT transcript should be pursued as therapeutic targets.	Proline	68-75	huntingtin	Mus musculus	48-51
30476627-5	2019	Combining homozygosity mapping with whole exome sequencing identified a novel homozygous nucleotide substitution c.575T &gt; C in the lipoma HMGIC fusion partner-like 5 gene (LHFPL5), that converted the 192nd amino acid residue in the protein from a leucine to a proline, p.(Leu192Pro).	Proline	263-270	LHFPL tetraspan subfamily member 5	Homo sapiens	134-168
30476627-5	2019	Combining homozygosity mapping with whole exome sequencing identified a novel homozygous nucleotide substitution c.575T &gt; C in the lipoma HMGIC fusion partner-like 5 gene (LHFPL5), that converted the 192nd amino acid residue in the protein from a leucine to a proline, p.(Leu192Pro).	Proline	263-270	LHFPL tetraspan subfamily member 5	Homo sapiens	175-181
31810154-7	2019	Remarkably, the 442nd site of these positive selection sites is in the tetramerization domain of TPH1 protein, and it is proline or leucine.	Proline	121-128	tryptophan hydroxylase 1	Homo sapiens	97-101
30859684-7	2019	RESULTS: We identified the proline substitution mutation p.Leu421Pro (c.1262T>C) in the 2B domain of K16 that is associated with PC in a Chinese family.	Proline	27-34	keratin 16	Homo sapiens	101-104
31753030-10	2019	Analysis of the amino acid sequence of ORF3 indicated two hydrophobic domains (HD) and single conserved proline-rich domain (PRD) PREPSAPP (PXXPXXPP) with a single PSAP motif found in C-terminal.	Proline	104-111	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	39-43
31578743-9	2019	CONCLUSIONS: The TP53 codon 72 Pro/Pro polymorphism may isolate a relatively high-risk patient group in T1N1M0/T2N0M0/T3N0M0 gastric cancer.	Proline	31-34	tumor protein p53	Homo sapiens	17-21
31578743-9	2019	CONCLUSIONS: The TP53 codon 72 Pro/Pro polymorphism may isolate a relatively high-risk patient group in T1N1M0/T2N0M0/T3N0M0 gastric cancer.	Proline	35-38	tumor protein p53	Homo sapiens	17-21
31638198-11	2019	It was demonstated that only the whirlin N-terminal fragment was able to interact with espin and the PR (proline-rich) region in whirlin may be important for the interaction.	Proline	105-112	whirlin	Homo sapiens	33-40
31638198-11	2019	It was demonstated that only the whirlin N-terminal fragment was able to interact with espin and the PR (proline-rich) region in whirlin may be important for the interaction.	Proline	105-112	whirlin	Homo sapiens	129-136
32087070-9	2019	The significant difference in genotype distribution was observed in recessive model (Pro/Pro vs Arg/Arg + Arg/Pro) when stratifying by H. pylori infection (OR = 2.02, 95% CI 1.03-3.96, p = 0.041) and by cagA-positivity (OR = 2.33, 95% CI 1.07-5.07, p = 0.032).	Proline	85-88	S100 calcium binding protein A8	Homo sapiens	203-207
32087070-9	2019	The significant difference in genotype distribution was observed in recessive model (Pro/Pro vs Arg/Arg + Arg/Pro) when stratifying by H. pylori infection (OR = 2.02, 95% CI 1.03-3.96, p = 0.041) and by cagA-positivity (OR = 2.33, 95% CI 1.07-5.07, p = 0.032).	Proline	89-92	S100 calcium binding protein A8	Homo sapiens	203-207
32087070-9	2019	The significant difference in genotype distribution was observed in recessive model (Pro/Pro vs Arg/Arg + Arg/Pro) when stratifying by H. pylori infection (OR = 2.02, 95% CI 1.03-3.96, p = 0.041) and by cagA-positivity (OR = 2.33, 95% CI 1.07-5.07, p = 0.032).	Proline	89-92	S100 calcium binding protein A8	Homo sapiens	203-207
31753030-10	2019	Analysis of the amino acid sequence of ORF3 indicated two hydrophobic domains (HD) and single conserved proline-rich domain (PRD) PREPSAPP (PXXPXXPP) with a single PSAP motif found in C-terminal.	Proline	104-111	prosaposin	Homo sapiens	133-137
31729379-6	2019	An integrated transcriptomics and metabolomics analysis reveals that ADSL activates the oncogenic cMYC pathway by regulating cMYC protein level via a mechanism requiring ADSL proline 24 hydroxylation.	Proline	175-182	adenylosuccinate lyase	Homo sapiens	69-73
31504781-3	2019	In this study, the involvement in dark-induced senescence of proline dehydrogenases (ProDHs), which catalyse the first and rate-limiting step of proline oxidation in mitochondria, was investigated using prodh single- and double-mutants with the help of biochemical, proteomic, and metabolomic approaches.	Proline	61-68	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	203-208
31729379-6	2019	An integrated transcriptomics and metabolomics analysis reveals that ADSL activates the oncogenic cMYC pathway by regulating cMYC protein level via a mechanism requiring ADSL proline 24 hydroxylation.	Proline	175-182	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	98-102
31729379-6	2019	An integrated transcriptomics and metabolomics analysis reveals that ADSL activates the oncogenic cMYC pathway by regulating cMYC protein level via a mechanism requiring ADSL proline 24 hydroxylation.	Proline	175-182	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	125-129
30973753-6	2019	PSAT1 is required for de novo glycine production while ALDH18A1/P5CS is required for de novo proline production.	Proline	93-100	aldehyde dehydrogenase 18 family member A1	Homo sapiens	55-63
31173106-7	2019	RESULTS: GDC-0068 decreased cell viability, induced apoptosis, and inhibited phosphorylation of proline rich Akt substrate 40 kDa and p70 S6 kinase in a dose-dependent manner in PIK3CA-mutant breast cancer brain metastatic cell lines compared with PIK3CA-wildtype cell lines.	Proline	96-103	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	178-184
31173106-7	2019	RESULTS: GDC-0068 decreased cell viability, induced apoptosis, and inhibited phosphorylation of proline rich Akt substrate 40 kDa and p70 S6 kinase in a dose-dependent manner in PIK3CA-mutant breast cancer brain metastatic cell lines compared with PIK3CA-wildtype cell lines.	Proline	96-103	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	248-254
31781112-4	2019	Binding assays using recombinant rSP-A expressed in insect cells showed that lack of proline hydroxylation, truncations of amino-terminal oligomerization domains, and site-directed serine (S) or alanine (A) mutagenesis of cysteine 6 (C6S), glutamate 195 (E195A), and glutamate 171 (E171A) in the carbohydrate recognition domain (CRD) all impaired SP-A binding.	Proline	85-92	surfactant protein A1	Rattus norvegicus	33-38
30973753-6	2019	PSAT1 is required for de novo glycine production while ALDH18A1/P5CS is required for de novo proline production.	Proline	93-100	aldehyde dehydrogenase 18 family member A1	Homo sapiens	64-68
30973753-7	2019	Consistent with this, we found that TGF-beta treatment increased cellular levels of glycine and proline in lung fibroblasts.	Proline	96-103	transforming growth factor beta 1	Homo sapiens	36-44
31502061-4	2019	Galectin-3 is the only member of the chimeric galectins that has an N-terminal glycine and proline domain and a C-terminal carbohydrate recognition domain that allows galectin-3 to accommodate larger structures such us polylactosaminoglycans and intervene to DNA damage repair process.	Proline	91-98	galectin 3	Homo sapiens	0-10
31197859-2	2019	The activation is auto-inhibited by a putative helix N-terminal to the DH domain of TIM, which is stabilized by the intramolecular interaction of C-terminal SH3 domain with a proline-rich region 47 SSPRQPRKAL56 (termed as SSP peptide) between the putative helix and the DH domain.	Proline	175-182	Rho guanine nucleotide exchange factor 5	Homo sapiens	84-87
31430415-8	2019	Recently, great interest is concentrated on short proline-rich oligopeptides derived from IGF-1 degradation.	Proline	50-57	insulin like growth factor 1	Homo sapiens	90-95
31197859-5	2019	Here, considering that proline is the only endogenous N-substituted amino acid that plays a critical role in SH3-peptide recognition, the two key proline residues Pro49 and Pro52 in the core 49 PxxP52 motif of SSP peptide are systematically replaced by 19 N-substituted amino acid types to derive a variety of nonnatural peptoid ligands for TIM SH3 domain.	Proline	23-30	Rho guanine nucleotide exchange factor 5	Homo sapiens	341-344
31616795-4	2019	We identified two proteins, lens epithelium-derived growth factor (LEDGF) and hepatoma-derived growth factor 2 (HDGF2), each containing two high mobility group A (HMGA)-like AT-hooks and a methyl-lysine reading Pro-Trp-Trp-Pro (PWWP) domain that binds to H3K36me2 and H3K36me3.LEDGF and HDGF2 colocalize with H3K36me2/3 at genomic regions containing active genes.	Proline	211-214	PC4 and SFRS1 interacting protein 1	Homo sapiens	28-65
31484725-3	2019	Both ITK and LCK interact with TSAD"s proline-rich region (PRR) through their Src homology 3 (SH3) domains.	Proline	38-45	IL2 inducible T cell kinase	Homo sapiens	5-8
31484725-3	2019	Both ITK and LCK interact with TSAD"s proline-rich region (PRR) through their Src homology 3 (SH3) domains.	Proline	38-45	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
31484725-3	2019	Both ITK and LCK interact with TSAD"s proline-rich region (PRR) through their Src homology 3 (SH3) domains.	Proline	38-45	SH2 domain containing 2A	Homo sapiens	31-35
31600191-7	2019	The binding activity of DIP2A-PXXP motifs (P, proline; X, any residue) with the cortactin-Src homology 3 (SH3) domain was critical for maintaining the level of acetylated cortactin.	Proline	46-53	disco interacting protein 2 homolog A	Mus musculus	24-29
31600191-7	2019	The binding activity of DIP2A-PXXP motifs (P, proline; X, any residue) with the cortactin-Src homology 3 (SH3) domain was critical for maintaining the level of acetylated cortactin.	Proline	46-53	cortactin	Mus musculus	80-89
31616795-4	2019	We identified two proteins, lens epithelium-derived growth factor (LEDGF) and hepatoma-derived growth factor 2 (HDGF2), each containing two high mobility group A (HMGA)-like AT-hooks and a methyl-lysine reading Pro-Trp-Trp-Pro (PWWP) domain that binds to H3K36me2 and H3K36me3.LEDGF and HDGF2 colocalize with H3K36me2/3 at genomic regions containing active genes.	Proline	211-214	PC4 and SFRS1 interacting protein 1	Homo sapiens	67-72
31616795-4	2019	We identified two proteins, lens epithelium-derived growth factor (LEDGF) and hepatoma-derived growth factor 2 (HDGF2), each containing two high mobility group A (HMGA)-like AT-hooks and a methyl-lysine reading Pro-Trp-Trp-Pro (PWWP) domain that binds to H3K36me2 and H3K36me3.LEDGF and HDGF2 colocalize with H3K36me2/3 at genomic regions containing active genes.	Proline	211-214	HDGF like 3	Homo sapiens	78-110
31616795-4	2019	We identified two proteins, lens epithelium-derived growth factor (LEDGF) and hepatoma-derived growth factor 2 (HDGF2), each containing two high mobility group A (HMGA)-like AT-hooks and a methyl-lysine reading Pro-Trp-Trp-Pro (PWWP) domain that binds to H3K36me2 and H3K36me3.LEDGF and HDGF2 colocalize with H3K36me2/3 at genomic regions containing active genes.	Proline	211-214	HDGF like 3	Homo sapiens	112-117
31616795-4	2019	We identified two proteins, lens epithelium-derived growth factor (LEDGF) and hepatoma-derived growth factor 2 (HDGF2), each containing two high mobility group A (HMGA)-like AT-hooks and a methyl-lysine reading Pro-Trp-Trp-Pro (PWWP) domain that binds to H3K36me2 and H3K36me3.LEDGF and HDGF2 colocalize with H3K36me2/3 at genomic regions containing active genes.	Proline	223-226	PC4 and SFRS1 interacting protein 1	Homo sapiens	28-65
31616795-4	2019	We identified two proteins, lens epithelium-derived growth factor (LEDGF) and hepatoma-derived growth factor 2 (HDGF2), each containing two high mobility group A (HMGA)-like AT-hooks and a methyl-lysine reading Pro-Trp-Trp-Pro (PWWP) domain that binds to H3K36me2 and H3K36me3.LEDGF and HDGF2 colocalize with H3K36me2/3 at genomic regions containing active genes.	Proline	223-226	PC4 and SFRS1 interacting protein 1	Homo sapiens	67-72
31616795-4	2019	We identified two proteins, lens epithelium-derived growth factor (LEDGF) and hepatoma-derived growth factor 2 (HDGF2), each containing two high mobility group A (HMGA)-like AT-hooks and a methyl-lysine reading Pro-Trp-Trp-Pro (PWWP) domain that binds to H3K36me2 and H3K36me3.LEDGF and HDGF2 colocalize with H3K36me2/3 at genomic regions containing active genes.	Proline	223-226	HDGF like 3	Homo sapiens	78-110
31616795-4	2019	We identified two proteins, lens epithelium-derived growth factor (LEDGF) and hepatoma-derived growth factor 2 (HDGF2), each containing two high mobility group A (HMGA)-like AT-hooks and a methyl-lysine reading Pro-Trp-Trp-Pro (PWWP) domain that binds to H3K36me2 and H3K36me3.LEDGF and HDGF2 colocalize with H3K36me2/3 at genomic regions containing active genes.	Proline	223-226	HDGF like 3	Homo sapiens	112-117
31278967-9	2019	Pro, Gly and Ala were preferably found at P1-P4 and P2"-P4" in both tropoelastin and elastin.	Proline	0-3	elastin	Homo sapiens	68-80
31260699-4	2019	SNAP-23 Cys- mutant, devoid of all five cysteines, and SNAP-23 P119A (proline to alanine) mutant, that likely interferes with palmitoylation of SNAP-23 by palmitoyl transferases are completely cytosolic.	Proline	70-77	synaptosome associated protein 23	Rattus norvegicus	55-62
31278967-9	2019	Pro, Gly and Ala were preferably found at P1-P4 and P2"-P4" in both tropoelastin and elastin.	Proline	0-3	elastin	Homo sapiens	73-80
31431460-4	2019	IQGAP1 was identified as a GLK interacting protein; two proline-rich regions of GLK and the WW domain of IQGAP1 mediated this interaction.	Proline	56-63	IQ motif containing GTPase activating protein 1	Homo sapiens	0-6
31408067-2	2019	The lysine-proline-valine (KPV) tripeptide, which possesses anti-inflammatory properties and high affinity to peptide transporter 1 (PepT1), can target therapy-related cells (colonic epithelial cells and macrophages) via overexpression of PepT1.	Proline	11-18	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	110-131
31408067-2	2019	The lysine-proline-valine (KPV) tripeptide, which possesses anti-inflammatory properties and high affinity to peptide transporter 1 (PepT1), can target therapy-related cells (colonic epithelial cells and macrophages) via overexpression of PepT1.	Proline	11-18	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	133-138
31408067-2	2019	The lysine-proline-valine (KPV) tripeptide, which possesses anti-inflammatory properties and high affinity to peptide transporter 1 (PepT1), can target therapy-related cells (colonic epithelial cells and macrophages) via overexpression of PepT1.	Proline	11-18	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	239-244
31431460-4	2019	IQGAP1 was identified as a GLK interacting protein; two proline-rich regions of GLK and the WW domain of IQGAP1 mediated this interaction.	Proline	56-63	mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens	27-30
31431460-4	2019	IQGAP1 was identified as a GLK interacting protein; two proline-rich regions of GLK and the WW domain of IQGAP1 mediated this interaction.	Proline	56-63	mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens	80-83
31431460-4	2019	IQGAP1 was identified as a GLK interacting protein; two proline-rich regions of GLK and the WW domain of IQGAP1 mediated this interaction.	Proline	56-63	IQ motif containing GTPase activating protein 1	Homo sapiens	105-111
31399291-4	2019	Phosphorylated (p)-tau at Thr-Pro motifs can exist in the two distinct cis and trans conformations.	Proline	30-33	microtubule associated protein tau	Homo sapiens	19-22
31154002-3	2019	A common single nucleotide polymorphism within the Spry2 gene creates two protein variants where a proline adjacent to the serine rich domain is converted to an additional serine.	Proline	99-106	sprouty RTK signaling antagonist 2	Homo sapiens	51-56
31278393-5	2019	The eighth individual was heterozygous for a proline substitution, p.(Pro937Gln), at the boundary between TRPM3"s flexible pore-forming loop and an adjacent alpha-helix.	Proline	45-52	transient receptor potential cation channel subfamily M member 3	Homo sapiens	106-111
31357088-1	2019	Dipeptidyl peptidase 4 (DPP-4) is a serine protease, which has enzymatic activity to selectively clean the N-terminal dipeptide of peptides and proteins with proline or alanine in the second position.	Proline	158-165	dipeptidyl peptidase 4	Homo sapiens	0-22
31357088-1	2019	Dipeptidyl peptidase 4 (DPP-4) is a serine protease, which has enzymatic activity to selectively clean the N-terminal dipeptide of peptides and proteins with proline or alanine in the second position.	Proline	158-165	dipeptidyl peptidase 4	Homo sapiens	24-29
31493718-0	2019	Overexpression of the arginine decarboxylase gene promotes the symbiotic interaction Medicago truncatula-Sinorhizobium meliloti and induces the accumulation of proline and spermine in nodules under salt stress conditions.	Proline	160-167	arginine decarboxylase	Medicago truncatula	22-44
31539761-3	2019	Recently, we have found that proline content alterative 17 (pca17) is a double-mutant line in which both AtRZF1 (for Arabidopsis thaliana Ring Zinc Finger 1) and AHL (for Arabidopsis Halotolerance 2-like) genes are mutated.	Proline	29-36	RING/U-box superfamily protein	Arabidopsis thaliana	105-111
31539761-3	2019	Recently, we have found that proline content alterative 17 (pca17) is a double-mutant line in which both AtRZF1 (for Arabidopsis thaliana Ring Zinc Finger 1) and AHL (for Arabidopsis Halotolerance 2-like) genes are mutated.	Proline	29-36	HAL2-like protein	Arabidopsis thaliana	162-165
31539761-3	2019	Recently, we have found that proline content alterative 17 (pca17) is a double-mutant line in which both AtRZF1 (for Arabidopsis thaliana Ring Zinc Finger 1) and AHL (for Arabidopsis Halotolerance 2-like) genes are mutated.	Proline	29-36	HAL2-like protein	Arabidopsis thaliana	171-203
31539761-4	2019	It was found that insensitive response of atrzf1 mutant to abiotic stresses was suppressed in pca17 mutant by regulating proline metabolism.	Proline	121-128	RING/U-box superfamily protein	Arabidopsis thaliana	42-48
31366730-3	2019	Here, we identified a relatively rare mutation leading to a proline to leucine substitution (P152L) in TP53 at the very end of its DNA-binding domain (DBD) in a sample from an Indian oral cancer patient.	Proline	60-67	tumor protein p53	Homo sapiens	103-107
31407571-3	2019	Moreover, we completed an experiment to detect himan serum albumin (HSA) content in a mixture of human serum albumin and l-proline via dialysis.	Proline	121-130	albumin	Homo sapiens	53-66
31331957-5	2019	Cyclophilins catalyze the cis-trans isomerization of xaa-proline bonds, a rate-limiting step in protein folding which has been shown to be important for bacterial virulence.	Proline	57-64	peptidylprolyl isomerase B	Mus musculus	0-12
31362921-1	2019	Pyrroline-5-carboxylate reductase 1 (PYCR1) is the final enzyme involved in the biosynthesis of proline and has been found to be upregulated in various forms of cancer.	Proline	96-103	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-35
31433165-0	2019	Detection of Labile Conformations of Elastin"s Prolines by Solid-State Nuclear Magnetic Resonance and Fourier Transform Infrared Techniques.	Proline	47-55	elastin	Homo sapiens	37-44
31362921-1	2019	Pyrroline-5-carboxylate reductase 1 (PYCR1) is the final enzyme involved in the biosynthesis of proline and has been found to be upregulated in various forms of cancer.	Proline	96-103	pyrroline-5-carboxylate reductase 1	Homo sapiens	37-42
31362921-2	2019	Due to the role of proline in maintaining the redox balance of cells and preventing apoptosis, PYCR1 is emerging as an attractive oncology target.	Proline	19-26	pyrroline-5-carboxylate reductase 1	Homo sapiens	95-100
31362921-5	2019	We report the design and synthesis of the first tool compounds as PYCR1 inhibitors, derived from pargyline, which were assayed to assess their ability to attenuate the production of proline.	Proline	182-189	pyrroline-5-carboxylate reductase 1	Homo sapiens	66-71
31559416-3	2019	Proline oxidase, also known as proline dehydrogenase (POX/PRODH), is a key enzyme in the proline metabolism pathway and plays a vital role in tumorigenesis.	Proline	31-38	proline dehydrogenase 1	Homo sapiens	54-57
31341018-0	2019	MtpB, a member of the MttB superfamily from the human intestinal acetogen Eubacterium limosum, catalyzes proline betaine demethylation.	Proline	105-112	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	Homo sapiens	0-4
31341018-4	2019	MtpB along with MtqC (a corrinoid protein) and MtqA (a methylcorrinoid:tetrahydrofolate methyltransferase) was much more abundant in E. limosum cells grown on proline betaine than on lactate.	Proline	159-166	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	Homo sapiens	0-4
31559416-3	2019	Proline oxidase, also known as proline dehydrogenase (POX/PRODH), is a key enzyme in the proline metabolism pathway and plays a vital role in tumorigenesis.	Proline	31-38	proline dehydrogenase 1	Homo sapiens	58-63
31296381-5	2019	Structural and sequence comparison showed that hGas7-SH3 shares high similarity with Abl SH3 domain, which binds to a high-affinity proline-rich peptide P41 in a canonical SH3-ligand binding mode through two hydrophobic pockets and a specificity site in the RT-loop.	Proline	132-139	mitogen-activated protein kinase 1	Homo sapiens	153-156
31488087-9	2019	The SH3 and poly-proline+PxxDY regions of ABI1 were responsible for SOS1 and EPS8 binding, respectively.	Proline	17-24	abl interactor 1	Homo sapiens	42-46
31488087-9	2019	The SH3 and poly-proline+PxxDY regions of ABI1 were responsible for SOS1 and EPS8 binding, respectively.	Proline	17-24	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	68-72
31488087-9	2019	The SH3 and poly-proline+PxxDY regions of ABI1 were responsible for SOS1 and EPS8 binding, respectively.	Proline	17-24	epidermal growth factor receptor pathway substrate 8	Homo sapiens	77-81
31296381-5	2019	Structural and sequence comparison showed that hGas7-SH3 shares high similarity with Abl SH3 domain, which binds to a high-affinity proline-rich peptide P41 in a canonical SH3-ligand binding mode through two hydrophobic pockets and a specificity site in the RT-loop.	Proline	132-139	growth arrest specific 7	Homo sapiens	47-52
31296381-5	2019	Structural and sequence comparison showed that hGas7-SH3 shares high similarity with Abl SH3 domain, which binds to a high-affinity proline-rich peptide P41 in a canonical SH3-ligand binding mode through two hydrophobic pockets and a specificity site in the RT-loop.	Proline	132-139	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	85-88
31508505-7	2019	Although Cx32 has a long C-terminal tail, Cx32 hemichannels open to CO2 because the tail is conformationally restricted by the presence of proline residues.	Proline	139-146	gap junction protein beta 1	Homo sapiens	9-13
31508505-7	2019	Although Cx32 has a long C-terminal tail, Cx32 hemichannels open to CO2 because the tail is conformationally restricted by the presence of proline residues.	Proline	139-146	gap junction protein beta 1	Homo sapiens	42-46
31508505-7	2019	Although Cx32 has a long C-terminal tail, Cx32 hemichannels open to CO2 because the tail is conformationally restricted by the presence of proline residues.	Proline	139-146	complement C2	Homo sapiens	68-71
31239290-0	2019	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	Proline	81-88	egl-9 family hypoxia inducible factor 1	Homo sapiens	57-61
30919021-7	2019	In collagen 1alpha2 purified from Stt3b-silenced fibroblasts, decreased hydroxylation is found at five specific proline residues, while significantly increased hydroxylation is noted at two proline residues.	Proline	112-119	STT3 oligosaccharyltransferase complex catalytic subunit B	Homo sapiens	34-39
30919021-7	2019	In collagen 1alpha2 purified from Stt3b-silenced fibroblasts, decreased hydroxylation is found at five specific proline residues, while significantly increased hydroxylation is noted at two proline residues.	Proline	190-197	STT3 oligosaccharyltransferase complex catalytic subunit B	Homo sapiens	34-39
30919021-9	2019	These results suggest that N-linked glycosylation of P4HA1 can direct hydroxylation at specific proline residues and affect collagen maturation.	Proline	96-103	prolyl 4-hydroxylase subunit alpha 1	Homo sapiens	53-58
31402501-6	2019	(a) The ITAM and proline-rich sequence exposure model, in which the TCR"s cytoplasmic tails shield each other and ligand binding exposes them for phosphorylation.	Proline	17-24	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	68-71
31239290-0	2019	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	Proline	81-88	bromodomain containing 4	Homo sapiens	76-80
31239290-2	2019	Our previous study identified and validated Bromodomain-containing protein 4 (BRD4) as a proline hydroxylation substrate in cancer cells.	Proline	89-96	bromodomain containing 4	Homo sapiens	44-76
31239290-2	2019	Our previous study identified and validated Bromodomain-containing protein 4 (BRD4) as a proline hydroxylation substrate in cancer cells.	Proline	89-96	bromodomain containing 4	Homo sapiens	78-82
31239290-4	2019	In this study, we developed targeted quantification assays using parallel-reaction monitoring and biochemical analysis to identify the major regulatory enzyme of BRD4 proline hydroxylation.	Proline	167-174	bromodomain containing 4	Homo sapiens	162-166
31239290-6	2019	Our findings revealed that PHD2 is the key regulatory enzyme of BRD4 proline hydroxylation and the modification significantly affects BRD4 interactions with key transcription factors as well as BRD4-mediated transcriptional activation.	Proline	69-76	egl-9 family hypoxia inducible factor 1	Homo sapiens	27-31
31239290-6	2019	Our findings revealed that PHD2 is the key regulatory enzyme of BRD4 proline hydroxylation and the modification significantly affects BRD4 interactions with key transcription factors as well as BRD4-mediated transcriptional activation.	Proline	69-76	bromodomain containing 4	Homo sapiens	64-68
31239290-6	2019	Our findings revealed that PHD2 is the key regulatory enzyme of BRD4 proline hydroxylation and the modification significantly affects BRD4 interactions with key transcription factors as well as BRD4-mediated transcriptional activation.	Proline	69-76	bromodomain containing 4	Homo sapiens	134-138
31239290-6	2019	Our findings revealed that PHD2 is the key regulatory enzyme of BRD4 proline hydroxylation and the modification significantly affects BRD4 interactions with key transcription factors as well as BRD4-mediated transcriptional activation.	Proline	69-76	bromodomain containing 4	Homo sapiens	134-138
31377908-3	2019	HIP-55 constitutively binds HPK1 "via" an HPK1 proline-rich motif 2(PR2) through its C-terminal SH3 domain.	Proline	47-54	drebrin like	Homo sapiens	0-6
31402952-6	2019	The protein interaction profiles were different in each group; the STRING database identified three proteins that interacted with HSF1 directly, including insulin-like growth factor 1 receptor and small nuclear RNA-activating protein complex subunit 4 in Pro-C and small ubiquitin-related modifier 1 in Pro-S. Functional enrichment analysis of Gene Ontology revealed that the top terms were alternative splicing in Pro-S and polymorphism in Pro-C.	Proline	255-258	heat shock transcription factor 1	Homo sapiens	130-134
31402952-6	2019	The protein interaction profiles were different in each group; the STRING database identified three proteins that interacted with HSF1 directly, including insulin-like growth factor 1 receptor and small nuclear RNA-activating protein complex subunit 4 in Pro-C and small ubiquitin-related modifier 1 in Pro-S. Functional enrichment analysis of Gene Ontology revealed that the top terms were alternative splicing in Pro-S and polymorphism in Pro-C.	Proline	255-258	insulin like growth factor 1 receptor	Homo sapiens	155-192
31428870-2	2019	This analogue of the human amylin peptide (hIAPP) has triple proline substitutions typical of the rat isoform (rIAPP).	Proline	61-68	islet amyloid polypeptide	Homo sapiens	27-33
31443422-7	2019	The code evolved from a proto-tRNA a tetramer XCCA interacting with a proto-aminoacyl-tRNA synthetase (aaRS) activating Glycine and Proline, the initial expanded code is found in the acceptor arm of the tRNA, the operational code.	Proline	132-139	alanyl-tRNA synthetase 1	Homo sapiens	70-101
31443422-7	2019	The code evolved from a proto-tRNA a tetramer XCCA interacting with a proto-aminoacyl-tRNA synthetase (aaRS) activating Glycine and Proline, the initial expanded code is found in the acceptor arm of the tRNA, the operational code.	Proline	132-139	alanyl-tRNA synthetase 1	Homo sapiens	103-107
31247444-7	2019	Proline could suppress the browning of the plant callus by inhibition of PPO activity.	Proline	0-7	protoporphyrinogen oxidase, chloroplastic	Nicotiana tabacum	73-76
31315928-4	2019	NS5A-D2 comprises a short structural motif (PW-turn) embedded in a proline-rich sequence, whose interaction with the human prolyl isomerase cyclophilin A (CypA) is essential for viral RNA replication.	Proline	67-74	peptidylprolyl isomerase A	Homo sapiens	140-153
31315928-4	2019	NS5A-D2 comprises a short structural motif (PW-turn) embedded in a proline-rich sequence, whose interaction with the human prolyl isomerase cyclophilin A (CypA) is essential for viral RNA replication.	Proline	67-74	peptidylprolyl isomerase A	Homo sapiens	155-159
31461878-11	2019	With respect to the ECM, significantly higher ratios of the precursor protein proline to hydroxyproline were detected in hPL-cultured JPC monolayers (p < 0.001).	Proline	78-85	galectin 1	Homo sapiens	121-124
31428870-2	2019	This analogue of the human amylin peptide (hIAPP) has triple proline substitutions typical of the rat isoform (rIAPP).	Proline	61-68	islet amyloid polypeptide	Homo sapiens	43-48
31426446-4	2019	We describe for the first time that the cytoplasmic N-terminal half of GRINA (which spans a Proline-rich domain) contains a potential DNA-binding sequence, in addition to cleavage target sites and probable PY-nuclear localization sequences, that may enable it to be released from the rest of the protein and enter the nucleus under suitable conditions, where it could participate in the transcription, alternative splicing, and mRNA export of a subset of genes likely involved in lipid and sterol synthesis, ribosome biogenesis, or cell cycle progression.	Proline	92-99	glutamate ionotropic receptor NMDA type subunit associated protein 1	Homo sapiens	71-76
31142511-4	2019	Mechanistically, the N-terminal SRC homology 3 domains of CIN85 interacted with the proline-arginine-rich region within the N-terminus of PHD2, thereby inhibiting PHD2 activity and HIF degradation.	Proline	84-91	SH3-domain kinase binding protein 1	Mus musculus	58-63
31142511-4	2019	Mechanistically, the N-terminal SRC homology 3 domains of CIN85 interacted with the proline-arginine-rich region within the N-terminus of PHD2, thereby inhibiting PHD2 activity and HIF degradation.	Proline	84-91	egl-9 family hypoxia-inducible factor 1	Mus musculus	138-142
31413262-2	2019	Prolyl hydroxylase 2 (PHD2) dominantly hydroxylates two highly conserved proline residues of HIF-1alpha to promote its degradation.	Proline	73-80	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-20
31413262-2	2019	Prolyl hydroxylase 2 (PHD2) dominantly hydroxylates two highly conserved proline residues of HIF-1alpha to promote its degradation.	Proline	73-80	egl-9 family hypoxia inducible factor 1	Homo sapiens	22-26
31413262-2	2019	Prolyl hydroxylase 2 (PHD2) dominantly hydroxylates two highly conserved proline residues of HIF-1alpha to promote its degradation.	Proline	73-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-103
31229682-2	2019	One of the genes located in the deleted region of 22q11DS is Proline Dehydrogenase (PRODH) which is important for conversion of proline to glutamate.	Proline	128-135	proline dehydrogenase 1	Homo sapiens	61-82
31358628-9	2019	A variety of experiments and polarization transfer from water and mobile side chains indicate that 0N4R tau fibrils exhibit heterogeneous dynamics: Outside the rigid R2-R3 core, the R1 and R4 repeats are semirigid even though they exhibit beta-strand character and the proline-rich domains undergo large-amplitude anisotropic motions, whereas the two termini are nearly isotropically flexible.	Proline	269-276	microtubule associated protein tau	Homo sapiens	104-107
31393052-5	2019	Besides, sCD40L stimulation decreases splicing factor proline- and glutamine-rich protein (SFPQ) protein (one member of DBHS protein family) expression, while SFPQ overexpression suppresses sCD40L stimulation-induced proliferation and migration of pulmonary adventitial fibroblasts by repressing CD40 transcription.	Proline	54-61	splicing factor proline and glutamine rich	Homo sapiens	91-95
31393052-5	2019	Besides, sCD40L stimulation decreases splicing factor proline- and glutamine-rich protein (SFPQ) protein (one member of DBHS protein family) expression, while SFPQ overexpression suppresses sCD40L stimulation-induced proliferation and migration of pulmonary adventitial fibroblasts by repressing CD40 transcription.	Proline	54-61	CD40 molecule	Homo sapiens	10-14
31398828-5	2019	The protease side-activities mainly acted on the hydrophobic C-terminus of beta-CN at Ala, Pro, Ile, Phe, Leu, Lys, Gln, and Tyr positions, resulting in the formation of peptides, some of which were N-terminal glycated or potentially bitter.	Proline	91-94	apoptotic chromatin condensation inducer 1	Homo sapiens	75-82
31091146-2	2019	Previous studies of LGMD2i made use of a transgenic mouse model in which a proline-to-leucine (P448L) mutation in fukutin-related protein severely reduces glycosylation of alpha-dystroglycan.	Proline	75-82	fukutin related protein	Mus musculus	114-137
31229682-2	2019	One of the genes located in the deleted region of 22q11DS is Proline Dehydrogenase (PRODH) which is important for conversion of proline to glutamate.	Proline	128-135	proline dehydrogenase 1	Homo sapiens	84-89
31328231-4	2019	We here found that MSN2-overexpressing (MSN2-OE) cells showed higher sensitivity to a toxic analogue of proline, l-azetidine-2-carboxylic acid (AZC), as well as to the other amino acid toxic analogues, than wild-type cells.	Proline	104-111	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	19-23
31328231-4	2019	We here found that MSN2-overexpressing (MSN2-OE) cells showed higher sensitivity to a toxic analogue of proline, l-azetidine-2-carboxylic acid (AZC), as well as to the other amino acid toxic analogues, than wild-type cells.	Proline	104-111	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	40-44
31328231-5	2019	Overexpression of MSN2 increased the intracellular content of AZC, suggesting that Msn2 positively regulates the uptake of proline.	Proline	123-130	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	18-22
31328231-5	2019	Overexpression of MSN2 increased the intracellular content of AZC, suggesting that Msn2 positively regulates the uptake of proline.	Proline	123-130	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	83-87
31328231-6	2019	Among the known proline permease genes, GNP1 was shown to play a predominant role in the AZC toxicity.	Proline	16-23	glutamine permease GNP1	Saccharomyces cerevisiae S288C	40-44
31417867-5	2019	In addition, six genes including ODC1, SMS, SRM, RRM2, SMOX, and SAT1 associated with arginine and proline metabolism were found to be key players in this metabolic alteration.	Proline	99-106	ornithine decarboxylase 1	Homo sapiens	33-37
31026381-3	2019	A central common signaling mechanism in cancer is proline-directed phosphorylation, which is further regulated by the unique proline isomerase Pin1.	Proline	50-57	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	143-147
31026381-3	2019	A central common signaling mechanism in cancer is proline-directed phosphorylation, which is further regulated by the unique proline isomerase Pin1.	Proline	125-132	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	143-147
31306849-0	2019	The COOH-Terminal Proline-Rich Region of GRP78 Is a Key Regulator of Its Cell Surface Expression and Viability of Tamoxifen-Resistant Breast Cancer Cells.	Proline	18-25	heat shock protein family A (Hsp70) member 5	Homo sapiens	41-46
31306849-5	2019	We discovered that a proline-rich region (PRR) containing three consecutive prolines close to the COOH-terminus of GRP78 is important for its ability to form a complex with the partner protein, CD44v, as demonstrated by in vitro glutathione S-transferase pull-down assay.	Proline	21-28	nuclear receptor subfamily 1 group I member 2	Homo sapiens	42-45
31306849-5	2019	We discovered that a proline-rich region (PRR) containing three consecutive prolines close to the COOH-terminus of GRP78 is important for its ability to form a complex with the partner protein, CD44v, as demonstrated by in vitro glutathione S-transferase pull-down assay.	Proline	21-28	heat shock protein family A (Hsp70) member 5	Homo sapiens	115-120
31306849-5	2019	We discovered that a proline-rich region (PRR) containing three consecutive prolines close to the COOH-terminus of GRP78 is important for its ability to form a complex with the partner protein, CD44v, as demonstrated by in vitro glutathione S-transferase pull-down assay.	Proline	76-84	nuclear receptor subfamily 1 group I member 2	Homo sapiens	42-45
31306849-5	2019	We discovered that a proline-rich region (PRR) containing three consecutive prolines close to the COOH-terminus of GRP78 is important for its ability to form a complex with the partner protein, CD44v, as demonstrated by in vitro glutathione S-transferase pull-down assay.	Proline	76-84	heat shock protein family A (Hsp70) member 5	Homo sapiens	115-120
31306849-6	2019	Proline to alanine mutations at the PRR compromised GRP78 expression level on the cell surface as evidenced by purification of biotinylated cell surface proteins.	Proline	0-7	nuclear receptor subfamily 1 group I member 2	Homo sapiens	36-39
31306849-6	2019	Proline to alanine mutations at the PRR compromised GRP78 expression level on the cell surface as evidenced by purification of biotinylated cell surface proteins.	Proline	0-7	heat shock protein family A (Hsp70) member 5	Homo sapiens	52-57
31369573-5	2019	RESULTS: The allele frequency of TP53 codon 72 in our cohort was 37, 42, and 21% for Arg/Arg, Arg/Pro, and Pro/Pro, respectively.	Proline	98-101	tumor protein p53	Homo sapiens	33-37
31369573-5	2019	RESULTS: The allele frequency of TP53 codon 72 in our cohort was 37, 42, and 21% for Arg/Arg, Arg/Pro, and Pro/Pro, respectively.	Proline	107-110	tumor protein p53	Homo sapiens	33-37
31369573-5	2019	RESULTS: The allele frequency of TP53 codon 72 in our cohort was 37, 42, and 21% for Arg/Arg, Arg/Pro, and Pro/Pro, respectively.	Proline	107-110	tumor protein p53	Homo sapiens	33-37
31417867-5	2019	In addition, six genes including ODC1, SMS, SRM, RRM2, SMOX, and SAT1 associated with arginine and proline metabolism were found to be key players in this metabolic alteration.	Proline	99-106	ribonucleotide reductase regulatory subunit M2	Homo sapiens	49-53
31417867-5	2019	In addition, six genes including ODC1, SMS, SRM, RRM2, SMOX, and SAT1 associated with arginine and proline metabolism were found to be key players in this metabolic alteration.	Proline	99-106	spermine oxidase	Homo sapiens	55-59
31417867-5	2019	In addition, six genes including ODC1, SMS, SRM, RRM2, SMOX, and SAT1 associated with arginine and proline metabolism were found to be key players in this metabolic alteration.	Proline	99-106	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	65-69
31283229-0	2019	Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity.	Proline	166-173	kelch like ECH associated protein 1	Homo sapiens	103-108
31283229-0	2019	Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity.	Proline	166-173	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
31283229-4	2019	Comprehensive structure-activity analysis identified Pro as a preferred substituent, obtaining a potent inhibitor 35 with an IC50 of 43 nM in the competitive fluoresce polarization (FP) assay and a Kd value of 53.7 nM for Keap1 protein in the isothermal titration calorimetry (ITC) assay.	Proline	53-56	kelch like ECH associated protein 1	Homo sapiens	222-227
31283229-5	2019	The Pro analogue 35 exhibited tight and prolonged Keap1 binding in vitro and in cells, and treatment with 35 activated Nrf2-regulated cytoprotective response and antagonized acetaminophen-induced liver injury both in cellular and in vivo models.	Proline	4-7	kelch like ECH associated protein 1	Homo sapiens	50-55
31283229-5	2019	The Pro analogue 35 exhibited tight and prolonged Keap1 binding in vitro and in cells, and treatment with 35 activated Nrf2-regulated cytoprotective response and antagonized acetaminophen-induced liver injury both in cellular and in vivo models.	Proline	4-7	NFE2 like bZIP transcription factor 2	Homo sapiens	119-123
31428229-1	2019	Ankrd2 (ankyrin repeats containing domain 2) or Arpp (ankyrin repeat, PEST sequence, and proline-rich region) is a member of the muscle ankyrin repeat protein family.	Proline	89-96	ankyrin repeat domain 2	Homo sapiens	0-6
31428229-1	2019	Ankrd2 (ankyrin repeats containing domain 2) or Arpp (ankyrin repeat, PEST sequence, and proline-rich region) is a member of the muscle ankyrin repeat protein family.	Proline	89-96	ankyrin repeat domain 2	Homo sapiens	48-52
31167787-7	2019	We demonstrate the utility of this probe by sequencing the protein-protein interaction regions between the Hippo pathway protein Yes-associated protein 2 (YAP2) and tight junction protein 1 (TJP1 or ZO-1), uncovering interactions via the known binding domain as well as ZO-1"s MAGUK domain and YAP"s N-terminal proline-rich domain.	Proline	311-318	zonula occludens 1	Sus scrofa	199-203
31209055-7	2019	We suggest that the BCR forms within the lipid bilayer of the membrane a symmetric Igalpha-mHC:mHC-Igbeta complex that is stabilized by an aromatic proline-tyrosine interaction.	Proline	148-155	CD79a molecule	Homo sapiens	83-90
31244108-2	2019	A proline-centered pentapeptide isoconformational to arachidonic acid, which exhibited appreciable selectivity for COX-2, overcoming acetic acid- and formalin-induced pain in rats to almost 80%, was treated as a substrate by the enzyme.	Proline	2-9	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	115-120
31243994-0	2019	Conformational Isomerization Involving Conserved Proline Residues Modulates Oligomerization of the NS1 Interferon Response Inhibitor from the Syncytial Respiratory Virus.	Proline	49-56	influenza virus NS1A binding protein	Homo sapiens	99-102
31243994-2	2019	We hypothesized that two conserved proline residues, P81 and P67, participate in the conformational change leading to oligomerization.	Proline	35-42	ezrin	Homo sapiens	53-56
31243994-2	2019	We hypothesized that two conserved proline residues, P81 and P67, participate in the conformational change leading to oligomerization.	Proline	35-42	CD33 molecule	Homo sapiens	61-64
31269704-9	2019	sly-miR159 targeting of SlMYB33 transcription factor transcript correlated with accumulation of the osmoprotective compounds proline and putrescine, which promote drought tolerance.	Proline	125-132	MIR159	Solanum lycopersicum	4-10
31328047-7	2019	Under salt stress, the transgenic Arabidopsis over-expressed the WRKY56 gene, showing an increase in fresh weight, germination rate, proline content, and peroxidase and superoxide dismutase activity, when compared with the wild type.	Proline	133-140	WRKY DNA-binding protein 56	Arabidopsis thaliana	65-71
31209055-7	2019	We suggest that the BCR forms within the lipid bilayer of the membrane a symmetric Igalpha-mHC:mHC-Igbeta complex that is stabilized by an aromatic proline-tyrosine interaction.	Proline	148-155	BCR activator of RhoGEF and GTPase	Homo sapiens	20-23
31209055-7	2019	We suggest that the BCR forms within the lipid bilayer of the membrane a symmetric Igalpha-mHC:mHC-Igbeta complex that is stabilized by an aromatic proline-tyrosine interaction.	Proline	148-155	CD79b molecule	Homo sapiens	99-105
31045220-6	2019	Investigation of the HTR1A coding region in chimpanzees revealed a polymorphic site, where a C/A single nucleotide polymorphism changes a proline to a glutamine in the amino acid sequence (Pro248Gln).	Proline	138-145	5-hydroxytryptamine receptor 1A	Pan troglodytes	21-26
31044419-5	2019	Proline 127 is crucial for the formation of the Adenosine triphosphate binding pocket of the MYH11 motor domain and molecular modeling indicated that p.Pro127Ser alters nucleotide binding properties.	Proline	0-7	myosin heavy chain 11	Homo sapiens	93-98
31219365-5	2019	Expert opinion: The cyclin D1 gene encodes the regulatory subunit of a proline-directed serine-threonine kinase that phosphorylates several substrates.	Proline	71-78	cyclin D1	Homo sapiens	20-29
31219365-6	2019	CDKs possess phosphorylation site selectivity, with the phosphate-acceptor residue preceding a proline.	Proline	95-102	cyclin dependent kinase 6	Homo sapiens	0-4
31173534-3	2019	We recently generated a mouse model (named "DsppP19L/+ mice") that expressed a mutant DSPP in which the proline residue at position 19 was replaced by a leucine residue.	Proline	104-111	dentin sialophosphoprotein	Mus musculus	86-90
30387076-1	2019	The two most common polymorphisms of the human DRD4 gene encode a dopamine D4 receptor (D4R) with four or seven repeats of a proline-rich sequence of 16 amino acids (D4.4R or D4.7R).	Proline	125-132	dopamine receptor D4	Homo sapiens	66-86
30865168-3	2019	In cells, NCC phosphorylation is increased by lowering of intracellular chloride, via activation of the chloride-sensitive with no lysine (WNK)-SPAK/OSR1 (Ste20-related proline/alanine-rich kinase/oxidative stress response) kinase cascade.	Proline	169-176	Wnk kinase	Drosophila melanogaster	139-142
30865168-3	2019	In cells, NCC phosphorylation is increased by lowering of intracellular chloride, via activation of the chloride-sensitive with no lysine (WNK)-SPAK/OSR1 (Ste20-related proline/alanine-rich kinase/oxidative stress response) kinase cascade.	Proline	169-176	serine/threonine kinase 39	Mus musculus	144-148
30865168-3	2019	In cells, NCC phosphorylation is increased by lowering of intracellular chloride, via activation of the chloride-sensitive with no lysine (WNK)-SPAK/OSR1 (Ste20-related proline/alanine-rich kinase/oxidative stress response) kinase cascade.	Proline	169-176	odd-skipped related transcription factor 1	Mus musculus	149-153
30865168-3	2019	In cells, NCC phosphorylation is increased by lowering of intracellular chloride, via activation of the chloride-sensitive with no lysine (WNK)-SPAK/OSR1 (Ste20-related proline/alanine-rich kinase/oxidative stress response) kinase cascade.	Proline	169-176	serine/threonine kinase 24	Mus musculus	155-160
31112821-1	2019	The aberrant assembly of microtubule-associated protein Tau (tau) into insoluble aggregates is closely related to Alzheimer"s disease (AD), which is elicited from Tau phosphorylation events and regulated by the specific intermolecular recognition between the proline-rich PxxP motifs of Tau and the SH3 domains of its diverse partner proteins/kinases.	Proline	259-266	microtubule associated protein tau	Homo sapiens	56-59
31112821-1	2019	The aberrant assembly of microtubule-associated protein Tau (tau) into insoluble aggregates is closely related to Alzheimer"s disease (AD), which is elicited from Tau phosphorylation events and regulated by the specific intermolecular recognition between the proline-rich PxxP motifs of Tau and the SH3 domains of its diverse partner proteins/kinases.	Proline	259-266	microtubule associated protein tau	Homo sapiens	61-64
31112821-1	2019	The aberrant assembly of microtubule-associated protein Tau (tau) into insoluble aggregates is closely related to Alzheimer"s disease (AD), which is elicited from Tau phosphorylation events and regulated by the specific intermolecular recognition between the proline-rich PxxP motifs of Tau and the SH3 domains of its diverse partner proteins/kinases.	Proline	259-266	microtubule associated protein tau	Homo sapiens	163-166
31112821-1	2019	The aberrant assembly of microtubule-associated protein Tau (tau) into insoluble aggregates is closely related to Alzheimer"s disease (AD), which is elicited from Tau phosphorylation events and regulated by the specific intermolecular recognition between the proline-rich PxxP motifs of Tau and the SH3 domains of its diverse partner proteins/kinases.	Proline	259-266	microtubule associated protein tau	Homo sapiens	163-166
30387076-1	2019	The two most common polymorphisms of the human DRD4 gene encode a dopamine D4 receptor (D4R) with four or seven repeats of a proline-rich sequence of 16 amino acids (D4.4R or D4.7R).	Proline	125-132	dopamine receptor D4	Homo sapiens	47-51
31056254-2	2019	Ubiquitin-specific protease 3(USP3), a member of the USPs family, is a specific protease capable of cleavage of ubiquitin chains linked by proline residues.	Proline	139-146	ubiquitin specific peptidase 3	Homo sapiens	30-34
31078268-5	2019	Based on our data and the known structures of Homer1 EVH1 domain and RyR1, we found two consensus proline-rich sequences in the structure of RyR1, PPHHF and FLPPP, and proposed two corresponding binding models to show mechanisms of recognition different from those used by other proline-rich motifs.	Proline	98-105	homer scaffold protein 1	Homo sapiens	46-52
31078268-5	2019	Based on our data and the known structures of Homer1 EVH1 domain and RyR1, we found two consensus proline-rich sequences in the structure of RyR1, PPHHF and FLPPP, and proposed two corresponding binding models to show mechanisms of recognition different from those used by other proline-rich motifs.	Proline	98-105	ryanodine receptor 1	Homo sapiens	69-73
31078268-5	2019	Based on our data and the known structures of Homer1 EVH1 domain and RyR1, we found two consensus proline-rich sequences in the structure of RyR1, PPHHF and FLPPP, and proposed two corresponding binding models to show mechanisms of recognition different from those used by other proline-rich motifs.	Proline	98-105	ryanodine receptor 1	Homo sapiens	141-145
31078268-5	2019	Based on our data and the known structures of Homer1 EVH1 domain and RyR1, we found two consensus proline-rich sequences in the structure of RyR1, PPHHF and FLPPP, and proposed two corresponding binding models to show mechanisms of recognition different from those used by other proline-rich motifs.	Proline	279-286	homer scaffold protein 1	Homo sapiens	46-52
31078268-5	2019	Based on our data and the known structures of Homer1 EVH1 domain and RyR1, we found two consensus proline-rich sequences in the structure of RyR1, PPHHF and FLPPP, and proposed two corresponding binding models to show mechanisms of recognition different from those used by other proline-rich motifs.	Proline	279-286	ryanodine receptor 1	Homo sapiens	141-145
31078268-6	2019	The side proline residues of two proline-rich motifs from RyR1 are away from the hydrophobic surface of Homer1 EVH1, rather than buried in this hydrophobic surface.	Proline	9-16	ryanodine receptor 1	Homo sapiens	58-62
31078268-6	2019	The side proline residues of two proline-rich motifs from RyR1 are away from the hydrophobic surface of Homer1 EVH1, rather than buried in this hydrophobic surface.	Proline	33-40	ryanodine receptor 1	Homo sapiens	58-62
31108370-0	2019	SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.	Proline	76-83	sirtuin 3	Homo sapiens	0-5
31108370-0	2019	SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.	Proline	76-83	pyrroline-5-carboxylate reductase 1	Homo sapiens	67-72
31108370-1	2019	SIRT3 is a major mitochondrial deacetylase, which regulates various metabolic pathways by deacetylation; however, the effect of SIRT3 on proline metabolism is not reported.	Proline	137-144	sirtuin 3	Homo sapiens	0-5
31108370-1	2019	SIRT3 is a major mitochondrial deacetylase, which regulates various metabolic pathways by deacetylation; however, the effect of SIRT3 on proline metabolism is not reported.	Proline	137-144	sirtuin 3	Homo sapiens	128-133
31108370-2	2019	Pyrroline-5-carboxylate reductase 1 (PYCR1) participates in proline synthesis process by catalyzing the reduction of P5C to proline with concomitant generation of NAD+ and NADP+.	Proline	60-67	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-35
31108370-2	2019	Pyrroline-5-carboxylate reductase 1 (PYCR1) participates in proline synthesis process by catalyzing the reduction of P5C to proline with concomitant generation of NAD+ and NADP+.	Proline	60-67	pyrroline-5-carboxylate reductase 1	Homo sapiens	37-42
31108370-2	2019	Pyrroline-5-carboxylate reductase 1 (PYCR1) participates in proline synthesis process by catalyzing the reduction of P5C to proline with concomitant generation of NAD+ and NADP+.	Proline	124-131	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-35
31108370-2	2019	Pyrroline-5-carboxylate reductase 1 (PYCR1) participates in proline synthesis process by catalyzing the reduction of P5C to proline with concomitant generation of NAD+ and NADP+.	Proline	124-131	pyrroline-5-carboxylate reductase 1	Homo sapiens	37-42
31108370-10	2019	Our findings on the regulation of PYCR1 linked proline metabolism with SIRT3, CBP and cell growth, thus providing a potential approach for cancer therapy.	Proline	47-54	pyrroline-5-carboxylate reductase 1	Homo sapiens	34-39
31108370-10	2019	Our findings on the regulation of PYCR1 linked proline metabolism with SIRT3, CBP and cell growth, thus providing a potential approach for cancer therapy.	Proline	47-54	sirtuin 3	Homo sapiens	71-76
31108370-10	2019	Our findings on the regulation of PYCR1 linked proline metabolism with SIRT3, CBP and cell growth, thus providing a potential approach for cancer therapy.	Proline	47-54	CREB binding protein	Homo sapiens	78-81
31100704-7	2019	In hydroponically grown tomato seedlings, AtJUB1 overexpression results in higher prolines levels and improves the maintenance of water content in the plant under salinity stress.	Proline	82-90	NAC domain containing protein 42	Arabidopsis thaliana	42-48
31213567-3	2019	Here, we evaluated a missense mutation in GRIN2B, causing a proline-to-threonine switch (P553T) in the GluN2B subunit of NMDAR, which was found in a 5-year-old patient with Rett-like syndrome with severe encephalopathy.	Proline	60-67	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	42-48
31213567-3	2019	Here, we evaluated a missense mutation in GRIN2B, causing a proline-to-threonine switch (P553T) in the GluN2B subunit of NMDAR, which was found in a 5-year-old patient with Rett-like syndrome with severe encephalopathy.	Proline	60-67	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	103-109
31213567-3	2019	Here, we evaluated a missense mutation in GRIN2B, causing a proline-to-threonine switch (P553T) in the GluN2B subunit of NMDAR, which was found in a 5-year-old patient with Rett-like syndrome with severe encephalopathy.	Proline	60-67	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	121-126
31015257-2	2019	Recently, an arginine to proline substitution (R1673P) in the S4 voltage-sensing helix of the fourth membrane-bound repeat of CaV2.1 was linked to a severe neurological disorder characterized by generalized hypotonia, ataxia, cerebellar atrophy, and global developmental delay.	Proline	25-32	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	126-132
30982635-3	2019	Interestingly, most of these UBQLN2 mutations reside in its proline-rich (Pxx) region, an important modulator of LLPS.	Proline	60-67	ubiquilin 2	Homo sapiens	29-35
30888050-3	2019	BCNP1 contains a pleckstrin homology domain, three proline-rich motifs, and a potential SH2 binding site, and is predominantly expressed by B cells.	Proline	51-58	niban apoptosis regulator 3	Mus musculus	0-5
30726512-6	2019	Our findings show clustering of variation similar to the British cohort and support a protective role for common genetic variation (rs117068593, p.R279C) in the proline-rich region and a functionally relevant role for rare genetic variation in the domains that mediate binding and activation of its interaction partner, Rab5.	Proline	161-168	RAB5A, member RAS oncogene family	Homo sapiens	320-324
31034797-6	2019	In addition, daidzin was further identified to induce expression of tetrameric globular form of proline-rich membrane anchor (PRiMA)-linked AChE.	Proline	96-103	proline rich membrane anchor 1	Rattus norvegicus	126-131
31034797-6	2019	In addition, daidzin was further identified to induce expression of tetrameric globular form of proline-rich membrane anchor (PRiMA)-linked AChE.	Proline	96-103	acetylcholinesterase	Rattus norvegicus	140-144
32259059-5	2019	Like all CC and CXC subfamily chemokine receptors, CCR1 lacks a critical proline residue found in the ICL2 consensus domain of rhodopsin-family GPCRs.	Proline	73-80	C-C motif chemokine receptor 1	Homo sapiens	51-55
30980380-0	2019	Substance P in Solution: Trans-to-Cis Configurational Changes of Penultimate Prolines Initiate Non-enzymatic Peptide Bond Cleavages.	Proline	77-85	tachykinin precursor 1	Homo sapiens	0-11
30959160-4	2019	By modulating multiple substrates, PTPN12, a member of the proline-, glutamic acid-, serine- and threonine-rich (PEST) family of PTPs, is an important regulator of cell migration and adhesion.	Proline	59-66	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	35-41
30047851-1	2019	The present study was designed to investigate the influence of two indispensable and two dispensable amino acids, including methionine, histidine, cysteine and proline, on the binding interaction between human serum albumin (HSA) and an antibiotic agent lomefloxacin (LMF).	Proline	160-167	albumin	Homo sapiens	210-223
30666556-0	2019	PIM1 kinase promotes gallbladder cancer cell proliferation via inhibition of proline-rich Akt substrate of 40 kDa (PRAS40).	Proline	77-84	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
30666556-0	2019	PIM1 kinase promotes gallbladder cancer cell proliferation via inhibition of proline-rich Akt substrate of 40 kDa (PRAS40).	Proline	77-84	AKT1 substrate 1	Homo sapiens	115-121
30112727-1	2019	PURPOSE: Although a preparation method for F-18-labeled proteins that used a cell-free translation system and 4-[18F]fluoro-L-proline instead of L-proline has been reported, its introduction depends on amino acid sequences of target proteins.	Proline	124-133	mastermind like domain containing 1	Homo sapiens	43-47
30999074-2	2019	In this study, we monitored the accumulation of proline and the activities of Delta1-pyrroline-5-carboxylate synthetase (P5CS) and Delta1-pyrroline-5-carboxylate reductase (P5CR), the key enzymes of proline biosynthesis, in different parts of 4-day-old seedlings of wheat (Triticum aestivum L. cv.	Proline	48-55	delta-1-pyrroline-5-carboxylate synthase 1	Triticum aestivum	84-119
30999074-2	2019	In this study, we monitored the accumulation of proline and the activities of Delta1-pyrroline-5-carboxylate synthetase (P5CS) and Delta1-pyrroline-5-carboxylate reductase (P5CR), the key enzymes of proline biosynthesis, in different parts of 4-day-old seedlings of wheat (Triticum aestivum L. cv.	Proline	48-55	delta-1-pyrroline-5-carboxylate synthase 1	Triticum aestivum	121-125
30999074-2	2019	In this study, we monitored the accumulation of proline and the activities of Delta1-pyrroline-5-carboxylate synthetase (P5CS) and Delta1-pyrroline-5-carboxylate reductase (P5CR), the key enzymes of proline biosynthesis, in different parts of 4-day-old seedlings of wheat (Triticum aestivum L. cv.	Proline	48-55	pyrroline-5-carboxylate reductase	Triticum aestivum	137-171
30999074-2	2019	In this study, we monitored the accumulation of proline and the activities of Delta1-pyrroline-5-carboxylate synthetase (P5CS) and Delta1-pyrroline-5-carboxylate reductase (P5CR), the key enzymes of proline biosynthesis, in different parts of 4-day-old seedlings of wheat (Triticum aestivum L. cv.	Proline	48-55	pyrroline-5-carboxylate reductase	Triticum aestivum	173-177
30999074-2	2019	In this study, we monitored the accumulation of proline and the activities of Delta1-pyrroline-5-carboxylate synthetase (P5CS) and Delta1-pyrroline-5-carboxylate reductase (P5CR), the key enzymes of proline biosynthesis, in different parts of 4-day-old seedlings of wheat (Triticum aestivum L. cv.	Proline	199-206	delta-1-pyrroline-5-carboxylate synthase 1	Triticum aestivum	84-119
30999074-2	2019	In this study, we monitored the accumulation of proline and the activities of Delta1-pyrroline-5-carboxylate synthetase (P5CS) and Delta1-pyrroline-5-carboxylate reductase (P5CR), the key enzymes of proline biosynthesis, in different parts of 4-day-old seedlings of wheat (Triticum aestivum L. cv.	Proline	199-206	delta-1-pyrroline-5-carboxylate synthase 1	Triticum aestivum	121-125
30999074-2	2019	In this study, we monitored the accumulation of proline and the activities of Delta1-pyrroline-5-carboxylate synthetase (P5CS) and Delta1-pyrroline-5-carboxylate reductase (P5CR), the key enzymes of proline biosynthesis, in different parts of 4-day-old seedlings of wheat (Triticum aestivum L. cv.	Proline	199-206	pyrroline-5-carboxylate reductase	Triticum aestivum	137-171
30999074-2	2019	In this study, we monitored the accumulation of proline and the activities of Delta1-pyrroline-5-carboxylate synthetase (P5CS) and Delta1-pyrroline-5-carboxylate reductase (P5CR), the key enzymes of proline biosynthesis, in different parts of 4-day-old seedlings of wheat (Triticum aestivum L. cv.	Proline	199-206	pyrroline-5-carboxylate reductase	Triticum aestivum	173-177
30999074-5	2019	Parallel to the rise in proline content, the activities of P5CS and P5CR increased markedly in these growing tissues under osmotic stress.	Proline	24-31	delta-1-pyrroline-5-carboxylate synthase 1	Triticum aestivum	59-63
30999074-5	2019	Parallel to the rise in proline content, the activities of P5CS and P5CR increased markedly in these growing tissues under osmotic stress.	Proline	24-31	pyrroline-5-carboxylate reductase	Triticum aestivum	68-72
30999074-10	2019	Treatment with the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO) reduced considerably the increase in the activities of P5CS and P5CR and suppressed the accumulation of proline by more than 85% in the stressed root tips and the leaf base.	Proline	210-217	delta-1-pyrroline-5-carboxylate synthase 1	Triticum aestivum	161-165
31060637-1	2019	SummaryProlyl endopeptidase (PREP) is a post-proline cleaving enzyme.	Proline	45-52	prolyl endopeptidase	Mus musculus	29-33
30876574-5	2019	The limits of detection for ammonium was 0.12 microg mL-1 and for proline was in the range from 0.7 to 4.1 microg mL-1, depending on the kind of wine (white, red, or sweet), for beer the LOD was 6 microg mL-1.	Proline	66-73	L1 cell adhesion molecule	Mus musculus	114-118
30876574-5	2019	The limits of detection for ammonium was 0.12 microg mL-1 and for proline was in the range from 0.7 to 4.1 microg mL-1, depending on the kind of wine (white, red, or sweet), for beer the LOD was 6 microg mL-1.	Proline	66-73	L1 cell adhesion molecule	Mus musculus	114-118
31160916-8	2019	Results: The distinct metabolites between PDR and NDR groups were significantly enriched in 9 KEGG pathways (P &lt; 0.05, impact &gt; 0.1), namely, alanine, aspartate and glutamate metabolism, caffeine metabolism, beta-alanine metabolism, purine metabolism, cysteine and methionine metabolism, sulfur metabolism, sphingosine metabolism, and arginine and proline metabolism.	Proline	354-361	serine/threonine kinase 38	Homo sapiens	50-53
31151465-3	2019	We found that the phosphorylation sites were highly proline directed and primarily mitogen-activated protein kinase (MAPK) dependent, due to particular activation of c-jun N-terminal protein kinase (JNK), a member of the MAPK family.	Proline	52-59	mitogen-activated protein kinase 8	Homo sapiens	166-197
31151465-3	2019	We found that the phosphorylation sites were highly proline directed and primarily mitogen-activated protein kinase (MAPK) dependent, due to particular activation of c-jun N-terminal protein kinase (JNK), a member of the MAPK family.	Proline	52-59	mitogen-activated protein kinase 8	Homo sapiens	199-202
31141247-1	2019	Transcription factor 19 (TCF19) harbors a forkhead association (FHA) domain, a proline-rich region, a PHD or RING finger region, suggesting that TCF19 possesses a powerful function.	Proline	79-86	transcription factor 19	Homo sapiens	25-30
31141247-1	2019	Transcription factor 19 (TCF19) harbors a forkhead association (FHA) domain, a proline-rich region, a PHD or RING finger region, suggesting that TCF19 possesses a powerful function.	Proline	79-86	transcription factor 19	Homo sapiens	145-150
31042025-5	2019	Here, we identified a putative small molecule binding site on K-RasG12D using computational analyses of the protein structure and then used a combination of computational and biochemical approaches to discover small molecules that may bind to this pocket, which we have termed the P110 site, due to its adjacency to proline 110.	Proline	316-323	endogenous retrovirus group K member 15	Homo sapiens	281-285
31147541-4	2019	In particular, a proline to leucine substitution in the predicted kinase domain of BSK3 enhances BR sensitivity and signaling to increase the extent of root elongation.	Proline	17-24	BR-signaling kinase 3	Arabidopsis thaliana	83-87
30849274-0	2019	Regulation of the proline regulatory axis and autophagy modulates stemness in TP73/p73 deficient cancer stem-like cells.	Proline	18-25	tumor protein p73	Homo sapiens	78-82
31128065-0	2019	TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population Objective: This study aimed at exploring the association of TP53 72Arg/Pro polymorphism and Risk of ChronicLymphocytic Leukemia and to assess the correlation between TP53 72Arg/Pro polymorphism and clinical parameter,hematological profile and some biological prognostic markers among Sudanese patients with chronic lymphocyticleukemia.	Proline	17-20	tumor protein p53	Homo sapiens	0-4
31128065-0	2019	TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population Objective: This study aimed at exploring the association of TP53 72Arg/Pro polymorphism and Risk of ChronicLymphocytic Leukemia and to assess the correlation between TP53 72Arg/Pro polymorphism and clinical parameter,hematological profile and some biological prognostic markers among Sudanese patients with chronic lymphocyticleukemia.	Proline	17-20	tumor protein p53	Homo sapiens	217-221
31128065-0	2019	TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population Objective: This study aimed at exploring the association of TP53 72Arg/Pro polymorphism and Risk of ChronicLymphocytic Leukemia and to assess the correlation between TP53 72Arg/Pro polymorphism and clinical parameter,hematological profile and some biological prognostic markers among Sudanese patients with chronic lymphocyticleukemia.	Proline	17-20	tumor protein p53	Homo sapiens	217-221
31021607-7	2019	Pro in P1" and Iso in P1 are typical residues in peptides that ACE does not cleave.	Proline	0-3	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	63-66
31091804-5	2019	Biochemical assays showed that adult pycr1 KO fish have significantly reduced proline and extracellular matrix contents, lowered energy, and diminished superoxide dismutase (SOD) and telomerase activity when compared to the wild type fish, which suggested the pycr1 KO fish may have dysfunction in mitochondria.	Proline	78-85	pyrroline-5-carboxylate reductase 1, mitochondrial	Danio rerio	37-42
31123462-11	2019	Fine mapping revealed that the proline-rich domain of c-Cbl is critical for interaction with TRAF6.	Proline	31-38	Cbl proto-oncogene	Homo sapiens	54-59
31123462-11	2019	Fine mapping revealed that the proline-rich domain of c-Cbl is critical for interaction with TRAF6.	Proline	31-38	TNF receptor associated factor 6	Homo sapiens	93-98
31210839-12	2019	In addition, BLM downregulation significantly reduced levels of phosphorylated protein kinase B (AKT (Ser473)) and proline-rich AKT substrate of 40 kDa (PRAS40 (Thr246)), and this was accompanied by enhanced ROS (reactive oxygen species) levels.	Proline	115-122	BLM RecQ like helicase	Homo sapiens	13-16
31210839-12	2019	In addition, BLM downregulation significantly reduced levels of phosphorylated protein kinase B (AKT (Ser473)) and proline-rich AKT substrate of 40 kDa (PRAS40 (Thr246)), and this was accompanied by enhanced ROS (reactive oxygen species) levels.	Proline	115-122	AKT serine/threonine kinase 1	Homo sapiens	128-131
31210839-12	2019	In addition, BLM downregulation significantly reduced levels of phosphorylated protein kinase B (AKT (Ser473)) and proline-rich AKT substrate of 40 kDa (PRAS40 (Thr246)), and this was accompanied by enhanced ROS (reactive oxygen species) levels.	Proline	115-122	AKT1 substrate 1	Homo sapiens	153-159
30945869-9	2019	We showed that proline, position 584 in COL1A2, had a lower rate of modification in CRLM than in healthy liver.	Proline	15-22	collagen type I alpha 2 chain	Homo sapiens	40-46
30971428-5	2019	We found that Ssu72 dephosphorylates pSer5 effectively but only has low activities toward pSer7 and pSer2 The structural analysis revealed that Ssu72 requires that the proline residue in the substrate"s SP motif is in the cis configuration, forming a tight beta-turn for recognition by Ssu72.	Proline	168-175	Ssu72 CTD phosphatase	Drosophila melanogaster	14-19
30971428-5	2019	We found that Ssu72 dephosphorylates pSer5 effectively but only has low activities toward pSer7 and pSer2 The structural analysis revealed that Ssu72 requires that the proline residue in the substrate"s SP motif is in the cis configuration, forming a tight beta-turn for recognition by Ssu72.	Proline	168-175	Ssu72 CTD phosphatase	Drosophila melanogaster	144-149
30971428-5	2019	We found that Ssu72 dephosphorylates pSer5 effectively but only has low activities toward pSer7 and pSer2 The structural analysis revealed that Ssu72 requires that the proline residue in the substrate"s SP motif is in the cis configuration, forming a tight beta-turn for recognition by Ssu72.	Proline	168-175	Ssu72 CTD phosphatase	Drosophila melanogaster	144-149
31088535-0	2019	Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer.	Proline	13-20	glutaminase	Homo sapiens	63-74
30849274-0	2019	Regulation of the proline regulatory axis and autophagy modulates stemness in TP73/p73 deficient cancer stem-like cells.	Proline	18-25	tumor protein p73	Homo sapiens	83-86
30849274-6	2019	Mechanistically, TP73/p73 deficiency-induced autophagy occurs as a result of reduced ATP levels resulting from the metabolic perturbations within the proline regulatory axis.	Proline	150-157	tumor protein p73	Homo sapiens	17-21
30849274-6	2019	Mechanistically, TP73/p73 deficiency-induced autophagy occurs as a result of reduced ATP levels resulting from the metabolic perturbations within the proline regulatory axis.	Proline	150-157	tumor protein p73	Homo sapiens	22-25
30326144-4	2019	The purpose of this study is to determine whether the proline-rich (PXXP) domain of BAG3 is necessary for its cellular protection against hypoxia-reoxygenation (H/R) stress by binding to its chaperone, heat shock cognate 71 kDa protein (HSC70).	Proline	54-61	BAG cochaperone 3	Rattus norvegicus	84-88
30725116-5	2019	In response to 20 microM etoposide, the DNA/RNA-binding protein, non-POU domain-containing octamer-binding protein (NONO) and its dimerization partner splicing factor, proline/glutamine-rich (SFPQ) formed complexes with IGFBP-3, demonstrated in basal-like TNBC cell lines HCC1806 and MDA-MB-468.	Proline	168-175	non-POU domain containing octamer binding	Homo sapiens	65-114
30725116-5	2019	In response to 20 microM etoposide, the DNA/RNA-binding protein, non-POU domain-containing octamer-binding protein (NONO) and its dimerization partner splicing factor, proline/glutamine-rich (SFPQ) formed complexes with IGFBP-3, demonstrated in basal-like TNBC cell lines HCC1806 and MDA-MB-468.	Proline	168-175	non-POU domain containing octamer binding	Homo sapiens	116-120
30725116-5	2019	In response to 20 microM etoposide, the DNA/RNA-binding protein, non-POU domain-containing octamer-binding protein (NONO) and its dimerization partner splicing factor, proline/glutamine-rich (SFPQ) formed complexes with IGFBP-3, demonstrated in basal-like TNBC cell lines HCC1806 and MDA-MB-468.	Proline	168-175	splicing factor proline and glutamine rich	Homo sapiens	192-196
30725116-5	2019	In response to 20 microM etoposide, the DNA/RNA-binding protein, non-POU domain-containing octamer-binding protein (NONO) and its dimerization partner splicing factor, proline/glutamine-rich (SFPQ) formed complexes with IGFBP-3, demonstrated in basal-like TNBC cell lines HCC1806 and MDA-MB-468.	Proline	168-175	insulin like growth factor binding protein 3	Homo sapiens	220-227
30620086-7	2019	Cotton plant that overexpressed the GhGA2ox1 gene showed higher drought and salt tolerance than non-transgenic cotton plant, and these results were supported by data of higher free proline, chlorophyll, and relative water content in transgenic plant compared with control plant.	Proline	181-188	gibberellin 2-beta-dioxygenase 1	Gossypium hirsutum	36-44
30326144-4	2019	The purpose of this study is to determine whether the proline-rich (PXXP) domain of BAG3 is necessary for its cellular protection against hypoxia-reoxygenation (H/R) stress by binding to its chaperone, heat shock cognate 71 kDa protein (HSC70).	Proline	54-61	heat shock protein family A (Hsp70) member 8	Rattus norvegicus	202-235
30326144-4	2019	The purpose of this study is to determine whether the proline-rich (PXXP) domain of BAG3 is necessary for its cellular protection against hypoxia-reoxygenation (H/R) stress by binding to its chaperone, heat shock cognate 71 kDa protein (HSC70).	Proline	54-61	heat shock protein family A (Hsp70) member 8	Rattus norvegicus	237-242
30849449-2	2019	ERAP1 substrate preference is for peptides with hydrophobic or aliphatic N-terminal amino acids, with lower efficacy with charged and small hydrophilic amino acids and almost complete inefficiency with proline.	Proline	202-209	endoplasmic reticulum aminopeptidase 1	Homo sapiens	0-5
30877375-7	2019	A fully segregating missense variant (c.716C&gt;T) in exon 8 of ENAM substitutes a well-conserved proline to leucine, p.(Pro239Leu), resulting in a clinical hypomineralization of teeth.	Proline	98-105	enamelin	Canis lupus familiaris	64-68
30762925-4	2019	When Aspergillus terreus strain S-18 was cultured in a proline-enriched medium, intracellular l-ASNase was expressed in concurrence with reduced l-glutaminase (l-GLUase) and protease activities.	Proline	55-62	asparaginase and isoaspartyl peptidase 1	Homo sapiens	94-102
30796332-6	2019	MAC inhibited the hydroxylation of HIF-1alpha at the proline 564 residue, while it was reversed by ascorbate.	Proline	53-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
30718919-4	2019	Herein, we show that interference with proline isomerization in HER2/EGFR overexpressing cells also induces cancer cell death.	Proline	39-46	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
30651598-2	2019	Human epidemiological studies reveal that a p53 single-nucleotide polymorphism (SNP) at codon 72, encoding proline (P72) or arginine (R72), is associated with differential risk of several cancers, including BrCa.	Proline	107-114	tumor protein p53	Homo sapiens	44-47
30651598-2	2019	Human epidemiological studies reveal that a p53 single-nucleotide polymorphism (SNP) at codon 72, encoding proline (P72) or arginine (R72), is associated with differential risk of several cancers, including BrCa.	Proline	107-114	DEAD-box helicase 17	Homo sapiens	116-119
30718919-4	2019	Herein, we show that interference with proline isomerization in HER2/EGFR overexpressing cells also induces cancer cell death.	Proline	39-46	epidermal growth factor receptor	Homo sapiens	69-73
30914470-5	2019	Here, we present the connection between the lamin-like protein, CROWDED NUCLEI1 (CRWN1), and the chromatin- and PcG-associated component, PROLINE-TRYPTOPHANE-TRYPTOPHANE-PROLINE INTERACTOR OF POLYCOMBS1, in Arabidopsis (Arabidopsis thaliana).	Proline	138-145	little nuclei1	Arabidopsis thaliana	64-79
30914470-5	2019	Here, we present the connection between the lamin-like protein, CROWDED NUCLEI1 (CRWN1), and the chromatin- and PcG-associated component, PROLINE-TRYPTOPHANE-TRYPTOPHANE-PROLINE INTERACTOR OF POLYCOMBS1, in Arabidopsis (Arabidopsis thaliana).	Proline	138-145	little nuclei1	Arabidopsis thaliana	81-86
31035491-3	2019	At physiological oxygen levels (normoxia), HIF-prolyl hydroxylases (PHDs) hydroxylate proline residues on HIF-alpha subunits leading to their destabilization by promoting ubiquitination by the von-Hippel Lindau (VHL) ubiquitin ligase and subsequent proteasomal degradation.	Proline	86-93	von Hippel-Lindau tumor suppressor	Homo sapiens	193-210
30988205-3	2019	The p53 N terminus (NT) contains two transactivation domains (TAD1 and TAD2), a proline-rich region (PRR), and multiple phosphorylation sites.	Proline	80-87	tumor protein p53	Homo sapiens	4-7
31035491-3	2019	At physiological oxygen levels (normoxia), HIF-prolyl hydroxylases (PHDs) hydroxylate proline residues on HIF-alpha subunits leading to their destabilization by promoting ubiquitination by the von-Hippel Lindau (VHL) ubiquitin ligase and subsequent proteasomal degradation.	Proline	86-93	von Hippel-Lindau tumor suppressor	Homo sapiens	212-215
30824539-2	2019	To investigate the exocyst functions, here we exchanged proline for alanine in the highly conserved VXPX ciliary targeting motif of EXOC5 (exocyst complex component 5), a central exocyst gene/protein, and generated stable EXOC5 ciliary targeting sequence-mutated (EXOC5CTS-m) Madin-Darby canine kidney (MDCK) cells.	Proline	56-63	exocyst complex component 5	Canis lupus familiaris	132-137
30824539-2	2019	To investigate the exocyst functions, here we exchanged proline for alanine in the highly conserved VXPX ciliary targeting motif of EXOC5 (exocyst complex component 5), a central exocyst gene/protein, and generated stable EXOC5 ciliary targeting sequence-mutated (EXOC5CTS-m) Madin-Darby canine kidney (MDCK) cells.	Proline	56-63	exocyst complex component 5	Canis lupus familiaris	139-166
30992998-7	2019	While the gdh3/gdh3 mutant could grow on these carbon and nitrogen sources, the strain was locked in the yeast morphology in proline-containing medium.	Proline	125-132	glutamate dehydrogenase (NADP(+)) GDH3	Saccharomyces cerevisiae S288C	10-14
31080461-7	2019	Furthermore, GhWRKY6 overexpression in Arabidopsis modulated salt- and drought-sensitive phenotypes and stomatal aperture by regulating ABA signaling pathways, and reduced plant tolerance to abiotic stress through reactive oxygen species (ROS) enrichment, reduced proline content, and increased electrolytes and malondialdehyde (MDA).	Proline	264-271	probable WRKY transcription factor 21	Gossypium hirsutum	13-20
30995739-9	2019	Moreover, proline dehydrogenase (PRODH) was verified to regulate the levels of l-proline and downstream apoptotic factors (Bax, Bcl-2, and cleaved Caspase-3) compared with the control (p &lt; 0.05).	Proline	79-88	proline dehydrogenase	Mus musculus	10-31
30995739-9	2019	Moreover, proline dehydrogenase (PRODH) was verified to regulate the levels of l-proline and downstream apoptotic factors (Bax, Bcl-2, and cleaved Caspase-3) compared with the control (p &lt; 0.05).	Proline	79-88	proline dehydrogenase	Mus musculus	33-38
30995739-9	2019	Moreover, proline dehydrogenase (PRODH) was verified to regulate the levels of l-proline and downstream apoptotic factors (Bax, Bcl-2, and cleaved Caspase-3) compared with the control (p &lt; 0.05).	Proline	79-88	BCL2-associated X protein	Mus musculus	123-126
30808712-7	2019	Using TM4SF40-TM4SF20 chimeras, we identified Pro-29 of TM4SF20 as another important element required for RAT of the protein.	Proline	46-49	transmembrane 4 L six family member 20	Rattus norvegicus	56-63
31131313-0	2019	Mechano-regulation of proline metabolism and cancer progression by kindlin-2.	Proline	22-29	FERM domain containing kindlin 2	Homo sapiens	67-76
31131313-2	2019	We recently showed that increased stiffness of extracellular matrix is intrinsically linked to up-regulation of proline synthesis through a mechano-responsive fermitin family homolog 2 (FERMT2, best known as kindlin-2) and pyrroline-5-carboxylate reductase 1(PYCR1) complex, which in turn promotes collagen matrix synthesis, cell proliferation, survival, and cancer progression.	Proline	112-119	FERM domain containing kindlin 2	Homo sapiens	159-184
31131313-2	2019	We recently showed that increased stiffness of extracellular matrix is intrinsically linked to up-regulation of proline synthesis through a mechano-responsive fermitin family homolog 2 (FERMT2, best known as kindlin-2) and pyrroline-5-carboxylate reductase 1(PYCR1) complex, which in turn promotes collagen matrix synthesis, cell proliferation, survival, and cancer progression.	Proline	112-119	FERM domain containing kindlin 2	Homo sapiens	186-192
31131313-2	2019	We recently showed that increased stiffness of extracellular matrix is intrinsically linked to up-regulation of proline synthesis through a mechano-responsive fermitin family homolog 2 (FERMT2, best known as kindlin-2) and pyrroline-5-carboxylate reductase 1(PYCR1) complex, which in turn promotes collagen matrix synthesis, cell proliferation, survival, and cancer progression.	Proline	112-119	FERM domain containing kindlin 2	Homo sapiens	208-217
31131313-2	2019	We recently showed that increased stiffness of extracellular matrix is intrinsically linked to up-regulation of proline synthesis through a mechano-responsive fermitin family homolog 2 (FERMT2, best known as kindlin-2) and pyrroline-5-carboxylate reductase 1(PYCR1) complex, which in turn promotes collagen matrix synthesis, cell proliferation, survival, and cancer progression.	Proline	112-119	pyrroline-5-carboxylate reductase 1	Homo sapiens	223-258
31131313-2	2019	We recently showed that increased stiffness of extracellular matrix is intrinsically linked to up-regulation of proline synthesis through a mechano-responsive fermitin family homolog 2 (FERMT2, best known as kindlin-2) and pyrroline-5-carboxylate reductase 1(PYCR1) complex, which in turn promotes collagen matrix synthesis, cell proliferation, survival, and cancer progression.	Proline	112-119	pyrroline-5-carboxylate reductase 1	Homo sapiens	259-264
33405562-5	2019	Our results indicate that the fibroin/proline microneedles can act as carriers of insulin.	Proline	38-45	insulin	Homo sapiens	82-89
31218272-7	2019	Results: In vitro salivary protein-phytic acid interaction identified cystatin SN, a non-proline rich salivary protein, as the specific bound protein to phytic acid.	Proline	89-96	cystatin SN	Homo sapiens	70-81
30773881-0	2019	The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2alpha Signaling.	Proline	13-20	eukaryotic translation initiation factor 2A	Homo sapiens	76-85
30773881-2	2019	However, our studies also discovered that short-term treatment of asexual blood stage P. falciparum with HFG analogues causes a 20-fold increase in intracellular proline, termed the adaptive proline response (APR), which renders parasites tolerant to HFG.	Proline	162-169	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	209-212
30773881-2	2019	However, our studies also discovered that short-term treatment of asexual blood stage P. falciparum with HFG analogues causes a 20-fold increase in intracellular proline, termed the adaptive proline response (APR), which renders parasites tolerant to HFG.	Proline	191-198	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	209-212
30808712-7	2019	Using TM4SF40-TM4SF20 chimeras, we identified Pro-29 of TM4SF20 as another important element required for RAT of the protein.	Proline	46-49	transmembrane 4 L six family member 20	Rattus norvegicus	14-21
30992998-10	2019	It appears that the disequilibrium of cofactors in the gdh3/gdh3 mutant leads to characteristic proline degradation in the central carbon metabolism.	Proline	96-103	glutamate dehydrogenase (NADP(+)) GDH3	Saccharomyces cerevisiae S288C	55-59
30992998-10	2019	It appears that the disequilibrium of cofactors in the gdh3/gdh3 mutant leads to characteristic proline degradation in the central carbon metabolism.	Proline	96-103	glutamate dehydrogenase (NADP(+)) GDH3	Saccharomyces cerevisiae S288C	60-64
30944303-4	2019	Binding to a proline-tyrosine motif in the Akt-PH domain, SAV1 suppresses Akt activation by blocking Akt"s movement to plasma membrane.	Proline	13-20	AKT serine/threonine kinase 1	Homo sapiens	43-46
30944303-4	2019	Binding to a proline-tyrosine motif in the Akt-PH domain, SAV1 suppresses Akt activation by blocking Akt"s movement to plasma membrane.	Proline	13-20	salvador family WW domain containing protein 1	Homo sapiens	58-62
30944303-4	2019	Binding to a proline-tyrosine motif in the Akt-PH domain, SAV1 suppresses Akt activation by blocking Akt"s movement to plasma membrane.	Proline	13-20	AKT serine/threonine kinase 1	Homo sapiens	74-77
30944303-4	2019	Binding to a proline-tyrosine motif in the Akt-PH domain, SAV1 suppresses Akt activation by blocking Akt"s movement to plasma membrane.	Proline	13-20	AKT serine/threonine kinase 1	Homo sapiens	74-77
30418498-6	2019	Histological analysis showed that proline supplementation enhanced labyrinth zone in the placenta of mice at E12.5, mRNA levels for Vegf, Vegfr, Nos2, and Nos3, compared with the controls.	Proline	34-41	vascular endothelial growth factor A	Mus musculus	132-136
30418498-6	2019	Histological analysis showed that proline supplementation enhanced labyrinth zone in the placenta of mice at E12.5, mRNA levels for Vegf, Vegfr, Nos2, and Nos3, compared with the controls.	Proline	34-41	nitric oxide synthase 2, inducible	Mus musculus	145-149
30418498-6	2019	Histological analysis showed that proline supplementation enhanced labyrinth zone in the placenta of mice at E12.5, mRNA levels for Vegf, Vegfr, Nos2, and Nos3, compared with the controls.	Proline	34-41	nitric oxide synthase 3, endothelial cell	Mus musculus	155-159
30418498-7	2019	Western blot analysis showed that proline supplementation increased protein abundances of phosphorylated (p)-mTORC1, p-ribosomal protein S6 kinase (p70S6K), and p-eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), as well as the protein level of GCN2 (a negative regulator of mTORC1 signaling).	Proline	34-41	CREB regulated transcription coactivator 1	Mus musculus	109-115
30418498-7	2019	Western blot analysis showed that proline supplementation increased protein abundances of phosphorylated (p)-mTORC1, p-ribosomal protein S6 kinase (p70S6K), and p-eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), as well as the protein level of GCN2 (a negative regulator of mTORC1 signaling).	Proline	34-41	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	148-154
30418498-7	2019	Western blot analysis showed that proline supplementation increased protein abundances of phosphorylated (p)-mTORC1, p-ribosomal protein S6 kinase (p70S6K), and p-eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), as well as the protein level of GCN2 (a negative regulator of mTORC1 signaling).	Proline	34-41	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	163-224
30418498-7	2019	Western blot analysis showed that proline supplementation increased protein abundances of phosphorylated (p)-mTORC1, p-ribosomal protein S6 kinase (p70S6K), and p-eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), as well as the protein level of GCN2 (a negative regulator of mTORC1 signaling).	Proline	34-41	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	226-232
30418498-7	2019	Western blot analysis showed that proline supplementation increased protein abundances of phosphorylated (p)-mTORC1, p-ribosomal protein S6 kinase (p70S6K), and p-eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), as well as the protein level of GCN2 (a negative regulator of mTORC1 signaling).	Proline	34-41	eukaryotic translation initiation factor 2 alpha kinase 4	Mus musculus	267-271
30418498-7	2019	Western blot analysis showed that proline supplementation increased protein abundances of phosphorylated (p)-mTORC1, p-ribosomal protein S6 kinase (p70S6K), and p-eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), as well as the protein level of GCN2 (a negative regulator of mTORC1 signaling).	Proline	34-41	CREB regulated transcription coactivator 1	Mus musculus	297-303
30739093-4	2019	In marmosets (Callithrix), a nonsynonymous nucleotide substitution in the OXT gene codes for proline in the eighth residue position (Pro8-OT).	Proline	93-100	oxytocin-neurophysin 1	Callithrix jacchus	74-77
30939845-8	2019	Interestingly, expression of various spliceosome genes is enhanced by RNA-binding protein splicing factor proline- and glutamine-rich (PSF/SFPQ), leading to changes in the expression of AR transcript variants.	Proline	106-113	splicing factor proline and glutamine rich	Homo sapiens	135-138
30939845-8	2019	Interestingly, expression of various spliceosome genes is enhanced by RNA-binding protein splicing factor proline- and glutamine-rich (PSF/SFPQ), leading to changes in the expression of AR transcript variants.	Proline	106-113	splicing factor proline and glutamine rich	Homo sapiens	139-143
30971568-3	2019	Hemoglobin (Hb) Fontainebleau is a rare alpha globin chain variant [alpha 21(B2) Ala Pro], of which only three families have been reported from India in the past.	Proline	85-88	hemoglobin subunit alpha 2	Homo sapiens	40-52
30380361-1	2019	Prolyl endopeptidase (PREP) is an enzyme which cleaves several peptide hormones and neuropeptides on the carboxyl side of proline residues and is involved in many biological processes, including cell proliferation and differentiation, glucose metabolism, learning, memory, and cognitive disorders.	Proline	122-129	prolyl endopeptidase	Rattus norvegicus	0-20
30380361-1	2019	Prolyl endopeptidase (PREP) is an enzyme which cleaves several peptide hormones and neuropeptides on the carboxyl side of proline residues and is involved in many biological processes, including cell proliferation and differentiation, glucose metabolism, learning, memory, and cognitive disorders.	Proline	122-129	prolyl endopeptidase	Rattus norvegicus	22-26
30797067-6	2019	The amino terminal proline residue (P2) and invariant lysine residue (K33) which are critical active sites of tautomerase activity in mammalian MIF were also detected.	Proline	19-26	macrophage migration inhibitory factor	Homo sapiens	144-147
30925160-0	2019	Phosphorylation of a serine/proline-rich motif in oxysterol binding protein-related protein 4L (ORP4L) regulates cholesterol and vimentin binding.	Proline	28-35	vimentin	Homo sapiens	129-137
30511276-4	2019	Therefore, the aim of this study was to investigate the impact of the elastin-derived valine-glycine-valine-alanine-proline-glycine (VGVAPG) peptide on Ppargamma and beta-galactosidase (beta-Gal) expression in mouse cortical astrocytes in vitro.	Proline	116-123	elastin	Mus musculus	70-77
30511276-4	2019	Therefore, the aim of this study was to investigate the impact of the elastin-derived valine-glycine-valine-alanine-proline-glycine (VGVAPG) peptide on Ppargamma and beta-galactosidase (beta-Gal) expression in mouse cortical astrocytes in vitro.	Proline	116-123	peroxisome proliferator activated receptor gamma	Mus musculus	152-161
30511276-4	2019	Therefore, the aim of this study was to investigate the impact of the elastin-derived valine-glycine-valine-alanine-proline-glycine (VGVAPG) peptide on Ppargamma and beta-galactosidase (beta-Gal) expression in mouse cortical astrocytes in vitro.	Proline	116-123	galactosidase, beta 1	Mus musculus	166-184
30925160-3	2019	Here we report the functional characterization of a unique proline/serine-rich phosphorylation motif (S762SPSSPSS769) in the lipid binding OSBP-related domain of full-length ORP4L and a truncated variant ORP4S.	Proline	59-66	oxysterol binding protein	Homo sapiens	139-143
30925160-9	2019	We conclude that phosphorylation of a unique serine/proline motif in the ORD induces a conformation change in ORP4L that enhances interaction with vimentin and cholesterol extraction from membranes.	Proline	52-59	vimentin	Homo sapiens	147-155
30917308-4	2019	Similar to TTP, ZNF598 harbors three proline-rich motifs that bind the GYF domain of GIGYF1.	Proline	37-44	ZFP36 ring finger protein	Homo sapiens	11-14
30917308-4	2019	Similar to TTP, ZNF598 harbors three proline-rich motifs that bind the GYF domain of GIGYF1.	Proline	37-44	zinc finger protein 598, E3 ubiquitin ligase	Homo sapiens	16-22
30917308-4	2019	Similar to TTP, ZNF598 harbors three proline-rich motifs that bind the GYF domain of GIGYF1.	Proline	37-44	GRB10 interacting GYF protein 1	Homo sapiens	85-91
30593514-7	2019	Mechanistically, TAp73 modifies the proline regulatory axis through regulation of enzymes GLS, OAT, and PYCR1 involved in the interconversion of proline-glutamine-ornithine.	Proline	36-43	transformation related protein 73	Mus musculus	17-22
30984217-2	2019	O-glycosylated proteins such as the Arabidopsis IDA (INFLORESCENCE DEFICIENT IN ABSCISSION) peptide and Arabinogalactan proteins (AGPs) which undergo proline hydroxylation were demonstrated to participate in abscission regulation.	Proline	150-157	Putative membrane lipoprotein	Arabidopsis thaliana	53-90
30593514-7	2019	Mechanistically, TAp73 modifies the proline regulatory axis through regulation of enzymes GLS, OAT, and PYCR1 involved in the interconversion of proline-glutamine-ornithine.	Proline	36-43	pyrroline-5-carboxylate reductase 1	Homo sapiens	104-109
30593514-7	2019	Mechanistically, TAp73 modifies the proline regulatory axis through regulation of enzymes GLS, OAT, and PYCR1 involved in the interconversion of proline-glutamine-ornithine.	Proline	145-152	transformation related protein 73	Mus musculus	17-22
30593514-7	2019	Mechanistically, TAp73 modifies the proline regulatory axis through regulation of enzymes GLS, OAT, and PYCR1 involved in the interconversion of proline-glutamine-ornithine.	Proline	145-152	pyrroline-5-carboxylate reductase 1	Homo sapiens	104-109
30394058-2	2019	Two common variations have been focused upon, one resulting in leucine or proline at codon 198 and another resulting in 5, 6, or 7 alanine repeats were previously shown to affect the distribution of GPX1 between the cytoplasm and mitochondria.	Proline	74-81	glutathione peroxidase 1	Homo sapiens	199-203
30872694-8	2019	Furthermore, the small peptide, S1, which mimics the AR proline-rich motif responsible for the interaction of AR with SH3-Src, reverses the effects in both cell lines, suggesting that the assembly of a complex made up of AR and Src drives the androgen-induced motility and invasiveness.	Proline	56-63	androgen receptor	Homo sapiens	53-55
30872694-8	2019	Furthermore, the small peptide, S1, which mimics the AR proline-rich motif responsible for the interaction of AR with SH3-Src, reverses the effects in both cell lines, suggesting that the assembly of a complex made up of AR and Src drives the androgen-induced motility and invasiveness.	Proline	56-63	androgen receptor	Homo sapiens	110-112
33654988-2	2019	A membrane-bound enzyme, oligosaccharyltransferase, catalyzes the transfer of an oligosaccharide chain from a sugar donor (lipid-linked oligosaccharide, LLO) to an asparagine residue in the consensus sequence, Asn-X-Ser/Thr (X   Pro), in proteins.	Proline	229-232	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	25-50
29667005-2	2019	L51P is molecularly engineered bone morphogentic protein-2 (BMP-2) variant with a substitution of the 51st leucine with a proline residue.	Proline	122-129	bone morphogenetic protein 2	Homo sapiens	31-58
29667005-2	2019	L51P is molecularly engineered bone morphogentic protein-2 (BMP-2) variant with a substitution of the 51st leucine with a proline residue.	Proline	122-129	bone morphogenetic protein 2	Homo sapiens	60-65
30600549-5	2019	In this study, we present evidence that single amino acid proline substitutions produce two different conformers of the membrane anchor domain of YadA; one with the N-termini facing the extracellular surface, and a second with the N-termini located in the periplasm.	Proline	58-65	Adhesin	Yersinia enterocolitica	146-150
30568170-5	2019	We found that the proline-rich domain (PRD) was necessary for ROR1 to recruit cortactin.	Proline	18-25	receptor tyrosine kinase-like orphan receptor 1	Mus musculus	62-66
30568170-5	2019	We found that the proline-rich domain (PRD) was necessary for ROR1 to recruit cortactin.	Proline	18-25	cortactin	Mus musculus	78-87
30568170-6	2019	We generated MEC1 cells that each expressed a mutant form of ROR1 with a single amino-acid substitution of alanine (A) for proline (P) in potential SH3-binding sites in the ROR1-PRD at positions 784, 808, 826, 841, or 850.	Proline	123-130	receptor tyrosine kinase-like orphan receptor 1	Mus musculus	61-65
30838327-6	2019	Specifically, molecular simulations of MaSp1 and MaSp2 proteins in dragline silk reveal that the unique torsional property originates from the presence of proline in MaSp2.	Proline	155-162	MBL associated serine protease 1	Homo sapiens	39-44
30637572-2	2019	AHL plays an intermediate role in the regulation of proline accumulation by PAP nucleotidase.	Proline	52-59	HAL2-like protein	Arabidopsis thaliana	0-3
30637572-5	2019	Using atrzf1 (Arabidopsis thaliana ring zinc finger 1) mutant as a parental line for T-DNA tagging mutagenesis, we identified a suppressor mutant designated as proline content alterative 17 (pca17) that suppressed insensitivity of atrzf1 to abiotic stresses during early seedling growth.	Proline	160-167	RING/U-box superfamily protein	Arabidopsis thaliana	6-12
30637572-5	2019	Using atrzf1 (Arabidopsis thaliana ring zinc finger 1) mutant as a parental line for T-DNA tagging mutagenesis, we identified a suppressor mutant designated as proline content alterative 17 (pca17) that suppressed insensitivity of atrzf1 to abiotic stresses during early seedling growth.	Proline	160-167	RING/U-box superfamily protein	Arabidopsis thaliana	14-53
30637572-5	2019	Using atrzf1 (Arabidopsis thaliana ring zinc finger 1) mutant as a parental line for T-DNA tagging mutagenesis, we identified a suppressor mutant designated as proline content alterative 17 (pca17) that suppressed insensitivity of atrzf1 to abiotic stresses during early seedling growth.	Proline	160-167	RING/U-box superfamily protein	Arabidopsis thaliana	231-237
30637572-12	2019	Collectively, these findings demonstrate that pca17 acts as a dominant suppressor mutant of atrzf1 in abiotic stress response by modulating proline and sulfate metabolism.	Proline	140-147	RING/U-box superfamily protein	Arabidopsis thaliana	92-98
30665058-5	2019	Compared to wild type (WT), the transgenic lines of TaZFP1 overexpression or knockdown displayed improved phenotypes, biomass, photosynthesis parameters (Pn, PsiPSII, and NPQ), osmolytes contents (i.e. proline and soluble sugar), and enhanced antioxidant enzyme (AE) activity following salt stress treatment.	Proline	202-209	E3 ubiquitin-protein ligase BRE1A	Triticum aestivum	52-58
30824759-6	2019	We revealed that the interaction between the SH3 domain of c-Src and the proline-rich region of Alix activates ESCRT-mediated intra-luminal vesicle (ILV) formation, resulting in the upregulation of exosome secretion in c-Src-transformed cells.	Proline	73-80	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	59-64
30824759-6	2019	We revealed that the interaction between the SH3 domain of c-Src and the proline-rich region of Alix activates ESCRT-mediated intra-luminal vesicle (ILV) formation, resulting in the upregulation of exosome secretion in c-Src-transformed cells.	Proline	73-80	programmed cell death 6 interacting protein	Homo sapiens	96-100
30824759-6	2019	We revealed that the interaction between the SH3 domain of c-Src and the proline-rich region of Alix activates ESCRT-mediated intra-luminal vesicle (ILV) formation, resulting in the upregulation of exosome secretion in c-Src-transformed cells.	Proline	73-80	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	219-224
30838327-6	2019	Specifically, molecular simulations of MaSp1 and MaSp2 proteins in dragline silk reveal that the unique torsional property originates from the presence of proline in MaSp2.	Proline	155-162	MBL associated serine protease 2	Homo sapiens	49-54
30838327-6	2019	Specifically, molecular simulations of MaSp1 and MaSp2 proteins in dragline silk reveal that the unique torsional property originates from the presence of proline in MaSp2.	Proline	155-162	MBL associated serine protease 2	Homo sapiens	166-171
30808876-3	2019	The aim of this study was to determine the expression levels of genes encoding MAPKs (MAPK3 and MAPK6), antioxidant enzymes (CAT, APX and GPX) and enzymes involved in proline biosynthesis (P5CS and P5CR) in Triticum aestivum L. seedlings in response to short-term drought conditions.	Proline	167-174	catalase-1	Triticum aestivum	125-128
30661786-3	2019	SFPQ, a proline and glutamine rich splicing factor that participates in diverse molecular functions including paraspeckle formation, microRNA synthesis and transcription regulation, is known to regulate host innate immune response to viruses.	Proline	8-15	splicing factor proline and glutamine rich	Homo sapiens	0-4
30816248-8	2019	Both strategies coincided to identify a fibrillogenic hotspot located at the CDR1 and beta-strand C of the protein, which was confirmed by scanning proline mutagenesis analysis.	Proline	148-155	cerebellar degeneration related protein 1	Homo sapiens	77-81
30808748-1	2019	The N-terminal region of the huntingtin protein, encoded by exon-1, comprises an amphiphilic domain (httNT), a polyglutamine (Q n ) tract, and a proline-rich sequence.	Proline	145-152	huntingtin	Homo sapiens	29-39
30808876-3	2019	The aim of this study was to determine the expression levels of genes encoding MAPKs (MAPK3 and MAPK6), antioxidant enzymes (CAT, APX and GPX) and enzymes involved in proline biosynthesis (P5CS and P5CR) in Triticum aestivum L. seedlings in response to short-term drought conditions.	Proline	167-174	APX	Triticum aestivum	130-133
30783087-0	2019	Kindlin-2 links mechano-environment to proline synthesis and tumor growth.	Proline	39-46	FERM domain containing kindlin 2	Homo sapiens	0-9
30853934-5	2019	P5CS is a critical enzyme in the conversion of glutamate to pyrroline-5-carboxylate, an intermediate that enters in the proline biosynthesis and that is connected with the urea cycle.	Proline	120-127	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-4
30783087-2	2019	We show here that a fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme for proline synthesis.	Proline	149-156	FERM domain containing kindlin 2	Homo sapiens	32-41
30783087-2	2019	We show here that a fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme for proline synthesis.	Proline	149-156	pyrroline-5-carboxylate reductase 1	Homo sapiens	87-122
30783087-2	2019	We show here that a fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme for proline synthesis.	Proline	149-156	pyrroline-5-carboxylate reductase 1	Homo sapiens	124-129
30783087-3	2019	Extracellular matrix (ECM) stiffening promotes kindlin-2 translocation into mitochondria and its interaction with PYCR1, resulting in elevation of PYCR1 level and consequent increase of proline synthesis and cell proliferation.	Proline	186-193	FERM domain containing kindlin 2	Homo sapiens	47-56
30783087-3	2019	Extracellular matrix (ECM) stiffening promotes kindlin-2 translocation into mitochondria and its interaction with PYCR1, resulting in elevation of PYCR1 level and consequent increase of proline synthesis and cell proliferation.	Proline	186-193	pyrroline-5-carboxylate reductase 1	Homo sapiens	114-119
30783087-4	2019	Depletion of kindlin-2 reduces PYCR1 level, increases reactive oxygen species (ROS) production and apoptosis, and abolishes ECM stiffening-induced increase of proline synthesis and cell proliferation.	Proline	159-166	FERM domain containing kindlin 2	Homo sapiens	13-22
30783087-6	2019	Ablation of kindlin-2 in lung adenocarcinoma substantially reduces PYCR1 and proline levels, and diminishes fibrosis in vivo, resulting in marked inhibition of tumor growth and reduction of mortality rate.	Proline	77-84	FERM domain containing kindlin 2	Homo sapiens	12-21
30783087-7	2019	Our findings reveal a mechanoresponsive kindlin-2-PYCR1 complex that links mechano-environment to proline metabolism and signaling, and suggest a strategy to inhibit tumor growth.	Proline	98-105	FERM domain containing kindlin 2	Homo sapiens	40-49
30783087-7	2019	Our findings reveal a mechanoresponsive kindlin-2-PYCR1 complex that links mechano-environment to proline metabolism and signaling, and suggest a strategy to inhibit tumor growth.	Proline	98-105	pyrroline-5-carboxylate reductase 1	Homo sapiens	50-55
30814930-7	2019	Comparison of AC3 KO and WT datasets revealed that phosphopeptides with motifs matching proline-directed kinases" recognition sites had a lower abundance in the KO dataset than in WTs.	Proline	88-95	adenylate cyclase 3	Mus musculus	14-17
30455352-1	2019	Hsp70 chaperones are central hubs of the protein quality control network and collaborate with co-chaperones having a J-domain (an ~70-residue-long helical hairpin with a flexible loop and a conserved His-Pro-Asp motif required for ATP hydrolysis by Hsp70s) and also with nucleotide exchange factors to facilitate many protein-folding processes that (re)establish protein homeostasis.	Proline	204-207	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
30792687-5	2019	One significantly down-regulated post-synaptic element in AD is the proline-rich SH3 and multiple-ankyrin-repeat domain SHANK3 protein.	Proline	68-75	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	120-126
30538129-4	2019	Huntingtin enters the nucleus via an importin beta1- and 2-dependent proline-tyrosine nuclear localization signal (PY-NLS), which has a unique intervening sequence in huntingtin.	Proline	69-76	huntingtin	Homo sapiens	0-10
30538129-4	2019	Huntingtin enters the nucleus via an importin beta1- and 2-dependent proline-tyrosine nuclear localization signal (PY-NLS), which has a unique intervening sequence in huntingtin.	Proline	69-76	transportin 1	Homo sapiens	37-58
30538129-4	2019	Huntingtin enters the nucleus via an importin beta1- and 2-dependent proline-tyrosine nuclear localization signal (PY-NLS), which has a unique intervening sequence in huntingtin.	Proline	69-76	huntingtin	Homo sapiens	167-177
30615305-3	2019	Bac5(1-25) is an N-terminal fragment of the bovine proline-rich antimicrobial peptide Bac5, whose mode of action has been recently described.	Proline	51-58	cathelicidin-2	Bos taurus	0-4
30615305-3	2019	Bac5(1-25) is an N-terminal fragment of the bovine proline-rich antimicrobial peptide Bac5, whose mode of action has been recently described.	Proline	51-58	cathelicidin-2	Bos taurus	86-90
28990412-1	2019	SIGNIFICANCE: Proline catabolism refers to the 4-electron oxidation of proline to glutamate catalyzed by the enzymes proline dehydrogenase (PRODH) and l-glutamate gamma-semialdehyde dehydrogenase (GSALDH, or ALDH4A1).	Proline	14-21	proline dehydrogenase 1	Homo sapiens	117-138
30805323-5	2019	The current case indicates that mutations resulting in substitution of a certain amino-acid (i.e., proline 339) by different amino-acids are manifested with different IPEX phenotypes.	Proline	99-106	forkhead box P3	Homo sapiens	167-171
30787867-4	2019	Caldendrin exhibit a unique bipartite structure with a basic and proline-rich N-terminus while calneurons are the only EF-Hand CaM-like transmembrane proteins.	Proline	65-72	calcium binding protein 1	Homo sapiens	0-10
28990412-1	2019	SIGNIFICANCE: Proline catabolism refers to the 4-electron oxidation of proline to glutamate catalyzed by the enzymes proline dehydrogenase (PRODH) and l-glutamate gamma-semialdehyde dehydrogenase (GSALDH, or ALDH4A1).	Proline	14-21	proline dehydrogenase 1	Homo sapiens	140-145
28990412-1	2019	SIGNIFICANCE: Proline catabolism refers to the 4-electron oxidation of proline to glutamate catalyzed by the enzymes proline dehydrogenase (PRODH) and l-glutamate gamma-semialdehyde dehydrogenase (GSALDH, or ALDH4A1).	Proline	14-21	aldehyde dehydrogenase 4 family member A1	Homo sapiens	151-195
30684192-1	2019	Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) induces conformational and functional changes to numerous key signaling molecules following proline-directed phosphorylation and its deregulation contributes to disease, particularly cancer.	Proline	154-161	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-54
30684192-1	2019	Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) induces conformational and functional changes to numerous key signaling molecules following proline-directed phosphorylation and its deregulation contributes to disease, particularly cancer.	Proline	154-161	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	56-60
28990412-1	2019	SIGNIFICANCE: Proline catabolism refers to the 4-electron oxidation of proline to glutamate catalyzed by the enzymes proline dehydrogenase (PRODH) and l-glutamate gamma-semialdehyde dehydrogenase (GSALDH, or ALDH4A1).	Proline	14-21	aldehyde dehydrogenase 4 family member A1	Homo sapiens	208-215
28990412-1	2019	SIGNIFICANCE: Proline catabolism refers to the 4-electron oxidation of proline to glutamate catalyzed by the enzymes proline dehydrogenase (PRODH) and l-glutamate gamma-semialdehyde dehydrogenase (GSALDH, or ALDH4A1).	Proline	71-78	proline dehydrogenase 1	Homo sapiens	117-138
28990412-1	2019	SIGNIFICANCE: Proline catabolism refers to the 4-electron oxidation of proline to glutamate catalyzed by the enzymes proline dehydrogenase (PRODH) and l-glutamate gamma-semialdehyde dehydrogenase (GSALDH, or ALDH4A1).	Proline	71-78	proline dehydrogenase 1	Homo sapiens	140-145
28990412-1	2019	SIGNIFICANCE: Proline catabolism refers to the 4-electron oxidation of proline to glutamate catalyzed by the enzymes proline dehydrogenase (PRODH) and l-glutamate gamma-semialdehyde dehydrogenase (GSALDH, or ALDH4A1).	Proline	71-78	aldehyde dehydrogenase 4 family member A1	Homo sapiens	151-195
28990412-1	2019	SIGNIFICANCE: Proline catabolism refers to the 4-electron oxidation of proline to glutamate catalyzed by the enzymes proline dehydrogenase (PRODH) and l-glutamate gamma-semialdehyde dehydrogenase (GSALDH, or ALDH4A1).	Proline	71-78	aldehyde dehydrogenase 4 family member A1	Homo sapiens	208-215
28990412-3	2019	In some bacteria, PRODH and GSALDH are combined into a bifunctional enzyme known as proline utilization A (PutA).	Proline	84-91	proline dehydrogenase 1	Homo sapiens	18-23
28990419-4	2019	On the biosynthetic side, two well-recognized oncogenes, c-MYC and phosphoinositide 3-kinase (PI3K), markedly upregulate enzymes of proline synthesis; mechanisms affected include augmented redox cycling and maintenance of pyridine nucleotides.	Proline	132-139	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	57-62
28990419-4	2019	On the biosynthetic side, two well-recognized oncogenes, c-MYC and phosphoinositide 3-kinase (PI3K), markedly upregulate enzymes of proline synthesis; mechanisms affected include augmented redox cycling and maintenance of pyridine nucleotides.	Proline	132-139	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	67-92
30485552-7	2019	This is confirmed by mutational analysis of ErbB4 that revealed a single point mutation at 3125 bp resulting in an amino acid change from proline to glutamine located at the carboxy-terminal region.	Proline	138-145	erb-b2 receptor tyrosine kinase 4	Rattus norvegicus	44-49
30911252-2	2019	Prolidase has an extremely important role in proline recycling for collagen synthesis.	Proline	45-52	peptidase D	Homo sapiens	0-9
30335548-5	2019	Mechanically, a typical proline, glutamic acid, serine, and threonine motif specifically existing in Smurf1 is necessary for its recognition and degradation by p97, and this process is dependent on p97 ATPase activity.	Proline	24-31	SMAD specific E3 ubiquitin protein ligase 1	Homo sapiens	101-107
30335548-5	2019	Mechanically, a typical proline, glutamic acid, serine, and threonine motif specifically existing in Smurf1 is necessary for its recognition and degradation by p97, and this process is dependent on p97 ATPase activity.	Proline	24-31	valosin containing protein	Homo sapiens	160-163
30335548-5	2019	Mechanically, a typical proline, glutamic acid, serine, and threonine motif specifically existing in Smurf1 is necessary for its recognition and degradation by p97, and this process is dependent on p97 ATPase activity.	Proline	24-31	valosin containing protein	Homo sapiens	198-201
30806030-7	2019	The mouse group receiving the GLP-1R agonist liraglutide has increased protein abundances of glutathione peroxidase-3 (GPX3) and catalase (CATA) while the abundances of neuroplastin (NPTN) and bifunctional glutamate/proline-tRNA ligase (SYEP) are decreased compared to the STZ vehicle mice.	Proline	216-223	glucagon-like peptide 1 receptor	Mus musculus	30-36
30690801-10	2019	The novel mutation, resulting in a substitution of alanine by proline, may lead to transformation of the SPTB protein structure, which affects the binding between SPTB and ankyrin.	Proline	62-69	spectrin beta, erythrocytic	Homo sapiens	105-109
30690801-10	2019	The novel mutation, resulting in a substitution of alanine by proline, may lead to transformation of the SPTB protein structure, which affects the binding between SPTB and ankyrin.	Proline	62-69	spectrin beta, erythrocytic	Homo sapiens	163-167
29989184-5	2019	The 42 bp deletion resulted in the deletion of a Proline Response Element (ProRE), and our results suggest that ProRE negatively regulates IPT5b expression in response to proline.	Proline	49-56	adenylate isopentenyltransferase 5, chloroplastic	Malus domestica	139-144
29989184-5	2019	The 42 bp deletion resulted in the deletion of a Proline Response Element (ProRE), and our results suggest that ProRE negatively regulates IPT5b expression in response to proline.	Proline	171-178	adenylate isopentenyltransferase 5, chloroplastic	Malus domestica	139-144
30697729-1	2019	Peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1 (PIN1) is a peptidyl-prolyl isomerase that binds phospho-Ser/Thr-Pro motifs in proteins and catalyzes the cis-trans isomerization of proline peptide bonds.	Proline	121-124	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-55
30697729-1	2019	Peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1 (PIN1) is a peptidyl-prolyl isomerase that binds phospho-Ser/Thr-Pro motifs in proteins and catalyzes the cis-trans isomerization of proline peptide bonds.	Proline	121-124	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	57-61
30697729-1	2019	Peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1 (PIN1) is a peptidyl-prolyl isomerase that binds phospho-Ser/Thr-Pro motifs in proteins and catalyzes the cis-trans isomerization of proline peptide bonds.	Proline	189-196	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-55
30697729-1	2019	Peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1 (PIN1) is a peptidyl-prolyl isomerase that binds phospho-Ser/Thr-Pro motifs in proteins and catalyzes the cis-trans isomerization of proline peptide bonds.	Proline	189-196	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	57-61
30523058-5	2019	Furthermore, biochemical assays reveal that the proline residue at the +1 site of the histone succinylation substrate is unfavorable for Sirt5 interaction.	Proline	48-55	sirtuin 5	Homo sapiens	137-142
30881620-0	2019	Neuropilin-1 peptide-like ligands with proline mimetics, tested using the improved chemiluminescence affinity detection method.	Proline	39-46	neuropilin 1	Homo sapiens	0-12
30723410-1	2018	PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis-trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability.	Proline	134-141	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
31115373-7	2019	Results: : Amino acids (proline and phenylalanine) exposure to adipocytes significantly (P &lt;0.01) increased APN mRNA by 1.5-folds when compared to control whereas proline increased APN secretion by 10.6-folds (P &lt;0.01), phenylalanine by 12.7-folds (P &lt;0.001) and alanine by 6.3-folds (P &lt;0.01).	Proline	24-31	adiponectin, C1Q and collagen domain containing	Homo sapiens	111-114
30095206-2	2019	The biosynthetic pathway includes a two-step proline oxidation catalyzed by phosphatidylinositol N-acetylglucosaminyltransferase subunit A (PigA), with flavin adenine dinucleotide (FAD) as its cofactor.	Proline	45-52	phosphatidylinositol glycan anchor biosynthesis class A	Homo sapiens	76-138
30095206-2	2019	The biosynthetic pathway includes a two-step proline oxidation catalyzed by phosphatidylinositol N-acetylglucosaminyltransferase subunit A (PigA), with flavin adenine dinucleotide (FAD) as its cofactor.	Proline	45-52	phosphatidylinositol glycan anchor biosynthesis class A	Homo sapiens	140-144
30645615-9	2019	The abundance of glycine, proline and aromatic residues in the C-terminal sequences from TAP-independently processed proteins allows the accessibility and specificity required for the proteolytic activities that generates the TAP-independent ligandome.	Proline	26-33	nuclear RNA export factor 1	Homo sapiens	89-92
30645615-9	2019	The abundance of glycine, proline and aromatic residues in the C-terminal sequences from TAP-independently processed proteins allows the accessibility and specificity required for the proteolytic activities that generates the TAP-independent ligandome.	Proline	26-33	nuclear RNA export factor 1	Homo sapiens	226-229
30625198-3	2019	Here, we characterise the microbicidal and immunomodulatory potential of the proline-rich bovine AMP, Bactenecin 5 (Bac5).	Proline	77-84	cathelicidin-2	Bos taurus	102-114
30625198-3	2019	Here, we characterise the microbicidal and immunomodulatory potential of the proline-rich bovine AMP, Bactenecin 5 (Bac5).	Proline	77-84	cathelicidin-2	Bos taurus	116-120
30543107-5	2019	Pathway analysis demonstrated that several metabolic pathways such as aminoacyl-tRNA biosynthesis, arginine and proline metabolism, and phenylalanine, tyrosine, and tryptophan biosynthesis were dysregulated in apoA-I knockout mice.	Proline	112-119	apolipoprotein A-I	Mus musculus	210-216
30255759-1	2019	BACKGROUND: Dipeptidyl Peptidase 4 (DPP 4) enzyme cleaves an incretin-based glucoregulatory hormone Glucagon Like Peptide -1 from N-terminal where penultimate amino acid is either alanine or proline.	Proline	191-198	dipeptidyl peptidase 4	Homo sapiens	12-34
30255759-1	2019	BACKGROUND: Dipeptidyl Peptidase 4 (DPP 4) enzyme cleaves an incretin-based glucoregulatory hormone Glucagon Like Peptide -1 from N-terminal where penultimate amino acid is either alanine or proline.	Proline	191-198	dipeptidyl peptidase 4	Homo sapiens	36-41
30255759-1	2019	BACKGROUND: Dipeptidyl Peptidase 4 (DPP 4) enzyme cleaves an incretin-based glucoregulatory hormone Glucagon Like Peptide -1 from N-terminal where penultimate amino acid is either alanine or proline.	Proline	191-198	glucagon	Homo sapiens	100-124
30467237-1	2019	CDC14A codes for a conserved proline-directed phosphatase, and mutations in the gene are associated with autosomal-recessive severe to profound deafness, due to defective kinocilia.	Proline	29-36	cell division cycle 14A	Homo sapiens	0-6
30525611-2	2019	The C-terminal intrinsically disordered domain of Pdx1 (Pdx1-C) has a heavily biased amino acid composition; most notably, 18 of 83 residues are proline, including a hexaproline cluster near the middle of the chain.	Proline	145-152	pancreatic and duodenal homeobox 1	Homo sapiens	50-54
30525611-2	2019	The C-terminal intrinsically disordered domain of Pdx1 (Pdx1-C) has a heavily biased amino acid composition; most notably, 18 of 83 residues are proline, including a hexaproline cluster near the middle of the chain.	Proline	145-152	pancreatic and duodenal homeobox 1	Homo sapiens	56-62
30621047-5	2019	The resulting vascular subnetwork demonstrates that ellagic acid, caffeic acid, protocatechuic acid, cryptotanshinone, tanshinone I, and tanshinone IIA are linked to NOS3, ARG2, and EDN1 for vascular dilation, implicated with arginine/proline metabolism.	Proline	235-242	nitric oxide synthase 3	Homo sapiens	166-170
30621047-5	2019	The resulting vascular subnetwork demonstrates that ellagic acid, caffeic acid, protocatechuic acid, cryptotanshinone, tanshinone I, and tanshinone IIA are linked to NOS3, ARG2, and EDN1 for vascular dilation, implicated with arginine/proline metabolism.	Proline	235-242	endothelin 1	Homo sapiens	182-186
30439382-3	2019	The aim of this study was to generate a novel long-acting IFNalpha with the help of PASylation technology that adds a polypeptide comprising Proline, Alanine and Serine (PAS) to increase plasma half-life.	Proline	141-148	interferon alpha 1	Homo sapiens	58-66
30391276-7	2019	We report a respective 48 and 34 discriminatory metabolites between Ndufs4-/- and WT white quadriceps and soleus muscles, among which the most prominent alterations indicate the involvement of the glycerol-3-phosphate shuttle, electron transfer flavoprotein system, CII, and proline cycle in fueling the Q cycle.	Proline	275-282	NADH:ubiquinone oxidoreductase core subunit S4	Mus musculus	68-74
30468644-3	2019	The FAP serine protease has the rare property of both dipeptidyl peptidase and endopeptidase activities capable of cleaving the post-proline bond at two or more residues from the N-terminus.	Proline	133-140	fibroblast activation protein alpha	Homo sapiens	4-7
30468644-3	2019	The FAP serine protease has the rare property of both dipeptidyl peptidase and endopeptidase activities capable of cleaving the post-proline bond at two or more residues from the N-terminus.	Proline	133-140	coagulation factor II, thrombin	Homo sapiens	8-23
31115373-7	2019	Results: : Amino acids (proline and phenylalanine) exposure to adipocytes significantly (P &lt;0.01) increased APN mRNA by 1.5-folds when compared to control whereas proline increased APN secretion by 10.6-folds (P &lt;0.01), phenylalanine by 12.7-folds (P &lt;0.001) and alanine by 6.3-folds (P &lt;0.01).	Proline	24-31	adiponectin, C1Q and collagen domain containing	Homo sapiens	184-187
31115373-7	2019	Results: : Amino acids (proline and phenylalanine) exposure to adipocytes significantly (P &lt;0.01) increased APN mRNA by 1.5-folds when compared to control whereas proline increased APN secretion by 10.6-folds (P &lt;0.01), phenylalanine by 12.7-folds (P &lt;0.001) and alanine by 6.3-folds (P &lt;0.01).	Proline	166-173	adiponectin, C1Q and collagen domain containing	Homo sapiens	184-187
30423454-0	2019	l-proline supplementation improves nitric oxide bioavailability and counteracts the blood pressure rise induced by angiotensin II in rats.	Proline	0-9	angiotensinogen	Rattus norvegicus	115-129
30257879-2	2019	This unique, constitutively active serine protease has both dipeptidyl aminopeptidase and endopeptidase activities and can hydrolyze the post-proline bond.	Proline	142-149	complement component 1, s subcomponent 1	Mus musculus	35-50
29704198-1	2019	Galectin-3 (Gal-3) is a chimeric protein structurally composed of unusual tandem repeats of proline and short glycine-rich segments fused onto a carbohydrate recognition domain.	Proline	92-99	galectin 3	Homo sapiens	0-17
30348461-5	2019	Furthermore, a comprehensive analysis of published UBQLN2 mutations demonstrated that only proline-rich domain mutations contribute to a significantly earlier age of onset in male patients (p = 0.0026).	Proline	91-98	ubiquilin 2	Homo sapiens	51-57
29806214-1	2019	Dipeptidyl peptidase-4 (DPP-4) cleaves N-terminal dipeptides, with Pro, Ala or Ser at the penultimate position, and, in that way, modulates biological activity of certain polypeptides.	Proline	67-70	dipeptidyl peptidase 4	Homo sapiens	0-22
29806214-1	2019	Dipeptidyl peptidase-4 (DPP-4) cleaves N-terminal dipeptides, with Pro, Ala or Ser at the penultimate position, and, in that way, modulates biological activity of certain polypeptides.	Proline	67-70	dipeptidyl peptidase 4	Homo sapiens	24-29
30389781-7	2019	We found that SIZ1 docks in the substrate-binding pocket of COP1 via two valine-proline peptide motifs, which represent a known interaction motif of COP1 substrates.	Proline	80-87	COP1 E3 ubiquitin ligase	Homo sapiens	60-64
30961476-15	2019	The other peptide hormones - PIP, CEP, CIF, and HypSys - that are rich in proline or hydroxyproline presumably prefer PPII.	Proline	74-81	prolactin induced protein	Homo sapiens	29-32
30239906-8	2019	The proline content and relative water content increased significantly, and some proline biosynthesis genes (AtP5CS1 and AtP5CS2) were also up-regulated in salt-stressed transgenic plants.	Proline	81-88	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	109-116
30239906-8	2019	The proline content and relative water content increased significantly, and some proline biosynthesis genes (AtP5CS1 and AtP5CS2) were also up-regulated in salt-stressed transgenic plants.	Proline	81-88	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	121-128
30414407-7	2018	When P1" is not proline, the orientations of the P2 and P2" side chains with respect to the scissile bond are reversed; P2 residues interact with a hydrophobic face of the S2 subsite, while the P2" amino acid usually engages hydrophilic amino acids in the S2" subsite.	Proline	16-23	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	49-58
30006991-2	2019	Pab1 consists of four RNA recognition motifs (RRM), a proline-rich domain (P) and a carboxy-terminal (C) domain.	Proline	54-61	polyadenylate-binding protein	Saccharomyces cerevisiae S288C	0-4
30094872-8	2019	The activation of the TORC1 pathway by a proline-to-glutamine upshift was indirectly evaluated using our system and the traditional direct methods based on immunoblot (Sch9 and Rps6 phosphorylation).	Proline	41-48	serine/threonine protein kinase SCH9	Saccharomyces cerevisiae S288C	168-172
30558541-3	2018	RESULTS: We analyzed the expression pattern of the proline biosynthetic genes PYRROLINE-5-CARBOXYLATE SYNTHETASE 1 &amp; 2 (P5CS1 &amp; 2) in Arabidopsis anthers and both isoforms were strongly expressed in developing microspores and pollen grains but only inconsistently in surrounding sporophytic tissues.	Proline	51-58	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	124-129
30557374-3	2018	Here we present evidence that the yeast transcription termination factor, Nab3, is targeted to intranuclear granules in response to glucose starvation by Nab3"s proline/glutamine-rich, prion-like domain (PrLD) which can assemble into amyloid in vitro.	Proline	161-168	Nab3p	Saccharomyces cerevisiae S288C	74-78
30557374-3	2018	Here we present evidence that the yeast transcription termination factor, Nab3, is targeted to intranuclear granules in response to glucose starvation by Nab3"s proline/glutamine-rich, prion-like domain (PrLD) which can assemble into amyloid in vitro.	Proline	161-168	Nab3p	Saccharomyces cerevisiae S288C	154-158
30607176-8	2018	The genotypic distribution at codon 72 of TP53 in control group was 20%, 62.4% and 16.6% for Arg (wildtype), Arg/Pro (heterozygous) and Pro (homozygous variant) respectively.	Proline	113-116	tumor protein p53	Homo sapiens	42-46
30282717-0	2019	The 11-Kilodalton Nonstructural Protein of Human Parvovirus B19 Facilitates Viral DNA Replication by Interacting with Grb2 through Its Proline-Rich Motifs.	Proline	135-142	growth factor receptor bound protein 2	Homo sapiens	118-122
30282717-6	2019	In vitro, one proline-rich motif was sufficient for 11-kDa to sustain a strong interaction with Grb2.	Proline	14-21	growth factor receptor bound protein 2	Homo sapiens	96-100
30282717-7	2019	In consistence, in vivo during infection, one proline-rich motif was enough for 11-kDa to significantly reduce phosphorylation of extracellular signal-regulated kinase (ERK).	Proline	46-53	mitogen-activated protein kinase 1	Homo sapiens	130-167
30282717-7	2019	In consistence, in vivo during infection, one proline-rich motif was enough for 11-kDa to significantly reduce phosphorylation of extracellular signal-regulated kinase (ERK).	Proline	46-53	mitogen-activated protein kinase 1	Homo sapiens	169-172
30282717-8	2019	Mutations of all three proline-rich motifs of 11-kDa abolished its capability to reduce ERK activity and, accordingly, decreased viral DNA replication.	Proline	23-30	mitogen-activated protein kinase 1	Homo sapiens	88-91
30282717-15	2019	In vitro, 11-kDa interacts with Grb2 with high affinity through three proline-rich motifs, of which at least one is indispensable for the regulation of viral DNA replication.	Proline	70-77	growth factor receptor bound protein 2	Homo sapiens	32-36
30544642-9	2018	We did this by detecting mistranslation in yeast cells with tRNASer derivatives having the UGA anticodon converted to UGG for proline.	Proline	126-133	tRNA-Ser (anticodon AGA) 2-3	Homo sapiens	60-67
30316783-4	2018	Proline-directed phosphorylation of MCM3 at S112 and T722 are crucial for the interaction with Pin1.	Proline	0-7	minichromosome maintenance complex component 3	Homo sapiens	36-40
30316783-4	2018	Proline-directed phosphorylation of MCM3 at S112 and T722 are crucial for the interaction with Pin1.	Proline	0-7	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	95-99
30414407-8	2018	These results reveal that the HIV-1 PR has evolved bi-functional S2 and S2" subsites to accommodate the steric effects imposed by a P1" proline on the orientation of P2 and P2" substrate side chains.	Proline	136-143	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	166-175
30244966-3	2018	We determined the nuclear magnetic resonance structure of the Syndapin3/PACSIN3 SH3 domain in complex with the TRPV4 N-terminal proline-rich region (PRR), which binds as a class I polyproline II (PPII) helix.	Proline	128-135	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	72-79
30574417-0	2018	A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder.	Proline	93-100	periostin	Homo sapiens	67-72
30244966-3	2018	We determined the nuclear magnetic resonance structure of the Syndapin3/PACSIN3 SH3 domain in complex with the TRPV4 N-terminal proline-rich region (PRR), which binds as a class I polyproline II (PPII) helix.	Proline	128-135	transient receptor potential cation channel subfamily V member 4	Homo sapiens	111-116
30318466-5	2018	The crystal structure of CBTAU-24.1 Fab with a phosphorylated tau peptide revealed recognition of a unique epitope (Ser235-Leu243) in the tau proline-rich domain.	Proline	142-149	FA complementation group B	Homo sapiens	36-39
30318466-5	2018	The crystal structure of CBTAU-24.1 Fab with a phosphorylated tau peptide revealed recognition of a unique epitope (Ser235-Leu243) in the tau proline-rich domain.	Proline	142-149	microtubule associated protein tau	Homo sapiens	62-65
30318466-5	2018	The crystal structure of CBTAU-24.1 Fab with a phosphorylated tau peptide revealed recognition of a unique epitope (Ser235-Leu243) in the tau proline-rich domain.	Proline	142-149	microtubule associated protein tau	Homo sapiens	138-141
31188078-6	2018	Results: There were significant differences between the two genotype groups of PPARgamma Pro12Ala polymorphism, Ala carriers (Pro/Ala + Ala/Ala) versus non-Ala carriers (Pro/Pro), in terms of mean body mass index (p = 0.04) and waist circumference (p = 0.02).	Proline	89-92	peroxisome proliferator activated receptor gamma	Homo sapiens	79-88
30309894-3	2018	We previously showed that three mutants based on apoE3 sequence, in which an arginine was substituted by proline, are thermodynamically destabilized and aggregation-prone.	Proline	105-112	apolipoprotein E	Homo sapiens	49-54
30414042-0	2018	A CON-based NMR assignment strategy for pro-rich intrinsically disordered proteins with low signal dispersion: the C-terminal domain of histone H1.0 as a case study.	Proline	40-43	H1.0 linker histone	Homo sapiens	136-148
30128672-2	2018	Several studies revealed that HSP47 has a role in numerous steps of collagen synthesis, preventing procollagen aggregation and inducing hydroxylation of proline and lysine residues.	Proline	153-160	serpin family H member 1	Homo sapiens	30-35
30547036-5	2018	Considering that most of the RBM20 mutations identified in familial DCM cases were heterozygous missense mutations in an arginine-serine-arginine-serine-proline (RSRSP) stretch whose phosphorylation is crucial for nuclear localization of RBM20, characterization of a knock-in animal model is awaited.	Proline	153-160	RNA binding motif protein 20	Mus musculus	29-34
30419598-3	2018	However, the role of proline 36, which is adjacent to the thrombin cleavage site at Arg37, has not yet been studied in detail.	Proline	21-28	coagulation factor II, thrombin	Homo sapiens	58-66
30504806-1	2018	The DNA sequence of the two human mucin genes MUC2 and MUC6 have not been completely resolved due to the repetitive nature of their central exon coding for Proline, Threonine and Serine rich sequences.	Proline	156-163	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	46-50
30504806-1	2018	The DNA sequence of the two human mucin genes MUC2 and MUC6 have not been completely resolved due to the repetitive nature of their central exon coding for Proline, Threonine and Serine rich sequences.	Proline	156-163	mucin 6, oligomeric mucus/gel-forming	Homo sapiens	55-59
30547036-5	2018	Considering that most of the RBM20 mutations identified in familial DCM cases were heterozygous missense mutations in an arginine-serine-arginine-serine-proline (RSRSP) stretch whose phosphorylation is crucial for nuclear localization of RBM20, characterization of a knock-in animal model is awaited.	Proline	153-160	RNA binding motif protein 20	Mus musculus	238-243
30460894-4	2018	Mechanistically, VP3 localizes to the mitochondria and mediates the phosphorylation of a previously unidentified SPLTSS motif within the MAVS proline-rich region, leading to its proteasomal degradation and blockade of IFN-lambda production in RV-infected intestinal epithelial cells.	Proline	142-149	mitochondrial antiviral signaling protein	Homo sapiens	137-141
30534074-3	2018	PIN1 specifically binds the phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif of its target proteins and catalyzes the cis/trans isomerization on the pSer/Thr-Pro peptide bonds.	Proline	83-90	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
30343942-4	2018	All the mutations affected the same highly conserved proline in PCGF2 and were de novo, excepting maternal mosaicism in one.	Proline	53-60	polycomb group ring finger 2	Homo sapiens	64-69
30487734-2	2018	Direct interaction of BIN1 and Tau proteins was demonstrated to be mediated through BIN1 SH3 C-terminal domain and Tau (210-240) peptide within Tau proline-rich domain.	Proline	148-155	bridging integrator 1	Homo sapiens	22-26
30487734-2	2018	Direct interaction of BIN1 and Tau proteins was demonstrated to be mediated through BIN1 SH3 C-terminal domain and Tau (210-240) peptide within Tau proline-rich domain.	Proline	148-155	bridging integrator 1	Homo sapiens	84-88
30487734-3	2018	We previously showed that BIN1 SH3 interaction with Tau is decreased by phosphorylation within Tau proline-rich domain, of at least T231.	Proline	99-106	bridging integrator 1	Homo sapiens	26-30
30487734-6	2018	Here we showed that within Tau (210-240) peptide, among the two proline-rich motifs potentially recognized by SH3 domains, only motif P216TPPTR221 is bound by BIN1 SH3.	Proline	64-71	bridging integrator 1	Homo sapiens	159-163
30487734-8	2018	P216 and P219 within the proline-rich motif were in direct contact with the aromatic F588 and W562 of the BIN1 SH3 domain.	Proline	25-32	bridging integrator 1	Homo sapiens	106-110
30409967-6	2018	Systematic analyses reveal that upon drought stress, increased BRL3 triggers the accumulation of osmoprotectant metabolites including proline and sugars.	Proline	134-141	BRI1-like 3	Arabidopsis thaliana	63-67
30410009-7	2018	The AtHKT1 expression enhanced the activities of SOD, CAT and POD, raised chlorophyll and soluble sugar contents and root activity, and decreased MDA and proline contents and electrolyte leakage destruction.	Proline	154-161	high-affinity K+ transporter 1	Arabidopsis thaliana	4-10
30088137-9	2018	Alteration of a specific proline residue (Pro590) of p63 was consistently linked to impaired perspiration.Conclusion: Hypohidrosis in p63-associated syndromes is less common and potentially less severe than previously thought and may be attributable to certain genotypes.	Proline	25-32	tumor protein p63	Homo sapiens	53-56
30542353-6	2018	In addition, the snx1-2 mutant with reduced NOS-like activity repressed the expression of stress-responsive genes, decreased proline accumulation and anti-oxidant ability compared with wild-type plants when subjected to salt stress.	Proline	125-132	sorting nexin 12	Homo sapiens	17-23
28841807-2	2018	In the current investigation, by control of the size and hydrodynamic volume at the nanoscale, for the first time, physicochemical and pharmacokinetic properties of an anti-VEGFA nanobody was remarkably improved by attachment of a Proline-Alanine-Serine (PAS) rich sequence.	Proline	231-239	vascular endothelial growth factor A	Homo sapiens	173-178
30088137-9	2018	Alteration of a specific proline residue (Pro590) of p63 was consistently linked to impaired perspiration.Conclusion: Hypohidrosis in p63-associated syndromes is less common and potentially less severe than previously thought and may be attributable to certain genotypes.	Proline	25-32	tumor protein p63	Homo sapiens	134-137
30099139-5	2018	The OnMAVS gene encodes 556 amino acids and contains a CARD, a proline-rich domain, a transmembrane helix domain and a putative TRAF2-binding motif (269PVQDT273).	Proline	63-70	mitochondrial antiviral-signaling protein	Oreochromis niloticus	4-10
30293761-0	2018	The diversity of the proline-rich domain of pneumococcal surface protein A (PspA): Potential relevance to a broad-spectrum vaccine.	Proline	21-28	surfactant protein A2	Homo sapiens	76-80
30166341-4	2018	CE is recruited to the cytoplasmic capping complex by binding of a C-terminal proline-rich sequence to the third Src homology 3 (SH3) domain of NCK adapter protein 1 (NCK1).	Proline	78-85	NCK adaptor protein 1	Homo sapiens	167-171
30367042-3	2018	By modulating alpha ketoglutarate (alpha-KG) and succinate levels P4HA1 expression reduces proline hydroxylation on hypoxia-inducible factor (HIF) 1alpha, enhancing its stability in cancer cells.	Proline	91-98	prolyl 4-hydroxylase subunit alpha 1	Homo sapiens	66-71
30367042-3	2018	By modulating alpha ketoglutarate (alpha-KG) and succinate levels P4HA1 expression reduces proline hydroxylation on hypoxia-inducible factor (HIF) 1alpha, enhancing its stability in cancer cells.	Proline	91-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-153
30382094-5	2018	Within the ternary Hsp90/FKBP51/Tau complex, Hsp90 serves as a scaffold that traps the PPIase and nucleates multiple conformations of Tau"s proline-rich region next to the PPIase catalytic pocket in a phosphorylation-dependent manner.	Proline	140-147	heat shock protein 90 alpha family class A member 1	Homo sapiens	19-24
30382094-5	2018	Within the ternary Hsp90/FKBP51/Tau complex, Hsp90 serves as a scaffold that traps the PPIase and nucleates multiple conformations of Tau"s proline-rich region next to the PPIase catalytic pocket in a phosphorylation-dependent manner.	Proline	140-147	heat shock protein 90 alpha family class A member 1	Homo sapiens	45-50
30382094-5	2018	Within the ternary Hsp90/FKBP51/Tau complex, Hsp90 serves as a scaffold that traps the PPIase and nucleates multiple conformations of Tau"s proline-rich region next to the PPIase catalytic pocket in a phosphorylation-dependent manner.	Proline	140-147	FKBP prolyl isomerase 10	Homo sapiens	87-93
30382094-5	2018	Within the ternary Hsp90/FKBP51/Tau complex, Hsp90 serves as a scaffold that traps the PPIase and nucleates multiple conformations of Tau"s proline-rich region next to the PPIase catalytic pocket in a phosphorylation-dependent manner.	Proline	140-147	FKBP prolyl isomerase 10	Homo sapiens	172-178
30460195-1	2018	Pin1 belongs to the family of the peptidyl-prolyl cis-trans isomerase (PPIase), which is a class of enzymes that catalyze the cis/trans isomerization of the Proline residue.	Proline	157-164	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
30460195-1	2018	Pin1 belongs to the family of the peptidyl-prolyl cis-trans isomerase (PPIase), which is a class of enzymes that catalyze the cis/trans isomerization of the Proline residue.	Proline	157-164	peptidylprolyl isomerase like 1	Homo sapiens	34-69
30460195-1	2018	Pin1 belongs to the family of the peptidyl-prolyl cis-trans isomerase (PPIase), which is a class of enzymes that catalyze the cis/trans isomerization of the Proline residue.	Proline	157-164	peptidylprolyl isomerase like 1	Homo sapiens	71-77
30460195-2	2018	Pin1 is unique and only catalyzes the phosphorylated Serine/Threonine-Proline (S/T-P) motifs of a subset of proteins.	Proline	70-77	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
30293761-3	2018	The proline-rich domain (PRD) in the center of the PspA sequence can also elicit protection.	Proline	4-11	surfactant protein A2	Homo sapiens	51-55
30239198-4	2018	The efficient nature of this chemistry is highlighted in the high-yielding one-pot assembly of two proline-rich polypeptide targets, submaxillary gland androgen regulated protein 3B and lumbricin-1.	Proline	99-106	submaxillary gland androgen regulated protein 3B	Homo sapiens	133-181
30252478-0	2018	Dynamics of the Proline-Rich C-Terminus of Huntingtin Exon-1 Fibrils.	Proline	16-23	huntingtin	Homo sapiens	43-53
30352950-7	2018	Sequence alignment showed that the activation loop of Fgr was distinct from that of all other Src family members, with proline rather than alanine at the +2 position relative to the activation loop tyrosine.	Proline	119-126	FGR proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	54-57
30314361-2	2018	The most extensively studied PPIase family member is protein interacting with never in mitosis A1 (PIN1), which isomerizes phosphorylated serine/threonine-proline bonds.	Proline	155-162	FKBP prolyl isomerase 7	Homo sapiens	29-35
30332747-3	2018	Among the numerous protein coding genes of HSA21, dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A (DYRK1A) encodes a proline-directed serine/threonine and tyrosine kinase that plays pleiotropic roles in neurodevelopment in both physiological and pathological conditions.	Proline	135-142	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	50-115
30332747-3	2018	Among the numerous protein coding genes of HSA21, dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A (DYRK1A) encodes a proline-directed serine/threonine and tyrosine kinase that plays pleiotropic roles in neurodevelopment in both physiological and pathological conditions.	Proline	135-142	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	117-123
30314361-2	2018	The most extensively studied PPIase family member is protein interacting with never in mitosis A1 (PIN1), which isomerizes phosphorylated serine/threonine-proline bonds.	Proline	155-162	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	99-103
30314361-4	2018	Many proteins are targets of proline-directed phosphorylation and thus PIN1-mediated isomerization of proline bonds represents an important step in the regulation of a variety of cellular mechanisms.	Proline	29-36	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	71-75
30314361-4	2018	Many proteins are targets of proline-directed phosphorylation and thus PIN1-mediated isomerization of proline bonds represents an important step in the regulation of a variety of cellular mechanisms.	Proline	102-109	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	71-75
30291234-3	2018	Among them, CDPS DmtB1, encoded by the gene of dmt1 locus, can synthesize cyclo(L-Trp-L-Xaa) (with Xaa being Val, Pro, Leu, Ile, or Ala).	Proline	114-117	doublesex and mab-3 related transcription factor 1	Homo sapiens	47-51
30026120-7	2018	Our mass spectrometry analyses, in addition, uncovered dynamic metabolomic reprogramming in AtWIND1-activated explants, including accumulation of several compounds, e.g. proline, gamma aminobutyric acid (GABA), and putrescine, that have historically been utilized as additives to enhance plant cell reprogramming in tissue culture.	Proline	170-177	related to AP2 4	Arabidopsis thaliana	92-99
30906830-3	2019	Pathogenicity of the frequent proline replacements, outside the DNA contact moiety of MBD, can be attributed to the role of this amino acid for maintaining both unfolded states for unbound MeCP2 and, at the same time, to favor some higher conformational order for stabilizing structural determinants required by protein activity.	Proline	30-37	methyl-CpG binding protein 2	Homo sapiens	189-194
30370308-7	2018	Several ZIP members show specific extracellular domains composed of two subdomains, a helix-rich domain and proline-alanine-leucine (PAL) motif-containing domain.	Proline	108-115	zinc finger CCCH-type and G-patch domain containing	Homo sapiens	8-11
29949095-0	2018	C-terminal proline deletions in KCNC3 cause delayed channel inactivation and an adult-onset progressive SCA13 with spasticity.	Proline	11-18	potassium voltage-gated channel subfamily C member 3	Homo sapiens	32-37
30774789-2	2018	Our research was aimed to study p53 protein codon 72 polymorphism, a single base pair change of either arginine (Arg; CGC) or proline (Pro; CCC) that creates 3 distinct genotypes in reticular oral lichen planus (OLP) in comparison to oral SCC which is the most common oral mucosal malignancy as positive control and inflammatory fibrous hyperplasia (IFH) lesion as negative control.	Proline	126-133	tumor protein p53	Homo sapiens	32-35
30774789-2	2018	Our research was aimed to study p53 protein codon 72 polymorphism, a single base pair change of either arginine (Arg; CGC) or proline (Pro; CCC) that creates 3 distinct genotypes in reticular oral lichen planus (OLP) in comparison to oral SCC which is the most common oral mucosal malignancy as positive control and inflammatory fibrous hyperplasia (IFH) lesion as negative control.	Proline	135-138	tumor protein p53	Homo sapiens	32-35
29944916-9	2018	Among others, alpha-ketoglutarate, hydroxyglutarate and certain amino acids (ornithine, proline and glycine) were reduced in the CS patient fibroblasts, whereas glycolytic intermediates (glucose-6-phosphate and pyruvic acid) and fatty acids (palmitic, stearic and myristic acid) were increased.	Proline	88-95	citrate synthase	Homo sapiens	129-131
29570813-2	2018	Polymorphisms in TAS2R38 generate two common haplotypes: the nonfunctional AVI (Alanine, Valine, Isoleucine) and the functional PAV (Proline, Alanine, Valine) alleles, with the latter protecting against gram-negative sinonasal infections.	Proline	133-140	taste 2 receptor member 38	Homo sapiens	17-24
29978433-3	2018	In this study, a nucleus-transducible form of BAF57, absent the proline-rich and HMG domains (ntBAF57-DeltaPH), was generated to interfere with the interaction between BAF57 and its binding protein, BAF155.	Proline	64-71	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	Mus musculus	46-51
30265671-3	2018	The cytoplasmic domain of ADAM15 was shown to selectively interact with the proline-rich linker of PABP.	Proline	76-83	ADAM metallopeptidase domain 15	Homo sapiens	26-32
30003470-3	2018	PR-39 is a pig-derived proline-rich antimicrobial peptide that has a broad spectrum of antibacterial activity and a low propensity for development of resistance by microorganisms.	Proline	23-30	antibacterial protein PR-39	Sus scrofa	0-5
30265671-3	2018	The cytoplasmic domain of ADAM15 was shown to selectively interact with the proline-rich linker of PABP.	Proline	76-83	poly(A) binding protein cytoplasmic 1	Homo sapiens	99-103
30004225-1	2018	We report the first purely chemical method for the resolution of C, N-unprotected racemic alpha-substituted beta-amino acids (beta2-AAs) using thermodynamically stable and recyclable chiral proline-derived ligands.	Proline	190-197	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	126-131
30256193-4	2018	Instead, we find that TFAP2 family members mediate the pro-lipid droplet signal induced by Wnt3a, leading to the notion that the TFAP2 transcription factor may function as a "master" regulator of lipid droplet biogenesis.	Proline	55-58	transcription factor AP-2 alpha	Homo sapiens	22-27
30256193-4	2018	Instead, we find that TFAP2 family members mediate the pro-lipid droplet signal induced by Wnt3a, leading to the notion that the TFAP2 transcription factor may function as a "master" regulator of lipid droplet biogenesis.	Proline	55-58	Wnt family member 3A	Homo sapiens	91-96
30256193-4	2018	Instead, we find that TFAP2 family members mediate the pro-lipid droplet signal induced by Wnt3a, leading to the notion that the TFAP2 transcription factor may function as a "master" regulator of lipid droplet biogenesis.	Proline	55-58	transcription factor AP-2 alpha	Homo sapiens	129-134
30122033-4	2018	The tandem qRRMs are connected through a 10-residue linker, with several amino acids strictly conserved between hnRNP H and F. A significant difference occurs at position 105 of the linker, where hnRNP H contains a proline and hnRNP F an alanine.	Proline	215-222	heterogeneous nuclear ribonucleoprotein H1	Homo sapiens	196-203
30031837-2	2018	In this study, we investigate the effect(s) of understanding the role of a conserved proline (P135), located in the heparin binding pocket, on the structure, stability, heparin binding affinity, and cell proliferation activity of hFGF1.	Proline	85-92	fibroblast growth factor 1	Homo sapiens	230-235
30217974-5	2018	The SPs of TRAP clients exhibit above-average glycine-plus-proline content and below-average hydrophobicity as distinguishing features.	Proline	59-66	TRAP	Homo sapiens	11-15
30217974-6	2018	Thus, TRAP may act as SP receptor on the ER membrane"s cytosolic face, recognizing precursor polypeptides with SPs of high glycine-plus-proline content and/or low hydrophobicity, and triggering substrate-specific opening of the Sec61 channel through interactions with the ER-lumenal hinge of Sec61alpha.	Proline	136-143	TRAP	Homo sapiens	6-10
30258354-2	2018	Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD).	Proline	52-59	lectin, galactose binding, soluble 3	Mus musculus	0-5
30250194-0	2018	The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis.	Proline	4-11	DEAD-box helicase 56	Homo sapiens	100-121
30242358-10	2018	Structural analysis suggested that this substitution could generate a novel hydrogen bond between the mutated residue 186 and proline at residue 192, thus potentially interrupting the tertiary structure and the stability of the IFT52 protein.	Proline	126-133	intraflagellar transport 52	Homo sapiens	228-233
30174330-9	2018	Whole exome sequencing of the proband identified a novel heterozygous C-T point mutation at nucleotide position 1069 of the AMBN gene, causing a Pro to Ser mutation at the conserved amino acid position 357 of the protein.	Proline	145-148	ameloblastin	Homo sapiens	124-128
29753770-7	2018	A proline, important for LPS recognition of mammalian TLR4, was also found in adaTLR4.	Proline	2-9	toll like receptor 4	Homo sapiens	54-58
29534931-3	2018	The introduction of a perfluoroalkyl-bridging group to constrain the peptides, coupled with a glutamic acid to proline replacement leads to a new peptide with a Ki of 6.1 nM for the Nrf2/Keap1 binding interaction, although this does not translate into intracellular activity.	Proline	111-118	NFE2 like bZIP transcription factor 2	Homo sapiens	182-186
29534931-3	2018	The introduction of a perfluoroalkyl-bridging group to constrain the peptides, coupled with a glutamic acid to proline replacement leads to a new peptide with a Ki of 6.1 nM for the Nrf2/Keap1 binding interaction, although this does not translate into intracellular activity.	Proline	111-118	kelch like ECH associated protein 1	Homo sapiens	187-192
30120361-3	2018	In the present study, 19F-NMR and cellular studies revealed that downstream of GPCR activation engagement of the receptor-phospho-tail with arrestin allosterically regulates the specific conformational states and functional outcomes of remote beta-arrestin 1 proline regions (PRs).	Proline	259-266	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	79-83
30007720-4	2018	beta-casomorphin (BCM) from milk casein, gluteomorphin (GM) from wheat gluten, and soymorphin (SM) from the soybean beta-conglycinin beta-subunit are natural substrates of DPPIV because of their amino acid sequences and proline location.	Proline	220-227	dipeptidyl peptidase 4	Homo sapiens	172-177
30066404-1	2018	Prolidase is a metallopeptidase that cleaves iminodipeptides containing a proline (Pro) or hydroxyproline (Hyp) residue at their C-terminal end.	Proline	74-81	peptidase D	Homo sapiens	0-9
30120361-3	2018	In the present study, 19F-NMR and cellular studies revealed that downstream of GPCR activation engagement of the receptor-phospho-tail with arrestin allosterically regulates the specific conformational states and functional outcomes of remote beta-arrestin 1 proline regions (PRs).	Proline	259-266	arrestin beta 1	Homo sapiens	243-258
29782957-2	2018	In addition, we have investigated potential neuroprotective effects of the hypothalamic proline-rich polypeptide (PRP-1).	Proline	88-95	tumor-associated calcium signal transducer 2	Rattus norvegicus	114-119
29980598-7	2018	A 1.5-A structure of the MLK3 SH3 domain bound to a canonical proline-rich peptide from hepatitis C virus nonstructural 5A (NS5A) protein revealed that it and MIP bind the SH3 domain at two distinct sites, but biophysical analyses suggested that the two peptides compete with each other for SH3 binding.	Proline	62-69	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	25-29
30185903-4	2018	The proline-rich motif in the RANKL cytoplasmic tail is required for reverse signalling, and a RANKL(Pro29Ala) point mutation reduces activation of the reverse signalling pathway.	Proline	4-11	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	30-35
30096237-5	2018	Additionally, slcbf1 mutants showed lower proline and protein contents and higher hydrogen peroxide contents and activities of antioxidant enzymes than WT plants.	Proline	42-49	C-repeat-binding factor-1	Solanum lycopersicum	14-20
30142213-5	2018	The multifunctional splicing factor proline and glutamine rich (SFPQ) was identified as one such protein.	Proline	36-43	splicing factor proline and glutamine rich	Homo sapiens	64-68
30158600-1	2018	Pin1 is the only known peptidyl-prolyl cis-trans isomerase (PPIase) that specifically recognizes and isomerizes the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) motif.	Proline	148-155	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
30158600-1	2018	Pin1 is the only known peptidyl-prolyl cis-trans isomerase (PPIase) that specifically recognizes and isomerizes the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) motif.	Proline	148-155	peptidylprolyl isomerase like 1	Homo sapiens	23-58
30158600-1	2018	Pin1 is the only known peptidyl-prolyl cis-trans isomerase (PPIase) that specifically recognizes and isomerizes the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) motif.	Proline	148-155	peptidylprolyl isomerase like 1	Homo sapiens	60-66
30186829-1	2018	The APO-type proline-arginine-rich host defense peptides exhibit potent in vitro killing parameters against Enterobacteriaceae but not to other bacteria.	Proline	13-20	anterior polar opacity	Mus musculus	4-7
30035541-0	2018	Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth.	Proline	52-59	thymidylate synthetase	Homo sapiens	97-117
30155513-3	2018	When expressed intracellularly as intrabodies, anti-alpha-syn nanobodies fused to a proteasome-targeting proline, aspartate or glutamate, serine, and threonine (PEST) motif can modulate monomeric concentrations of target proteins.	Proline	105-112	synuclein alpha	Rattus norvegicus	52-61
30177871-2	2018	The L-proline transporter PROT (Slc6A7) is believed to control the spatial and temporal distribution of L-proline at glutamatergic synapses by rapid uptake of this amino acid into presynaptic terminals.	Proline	4-13	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	Mus musculus	32-38
29381806-8	2018	Mechanistically, Pin1 recognizes and isomerizes the phosphorylated serine-proline motif of phosphorylated XPO5 and passivates phosphorylated XPO5.	Proline	74-81	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	17-21
30127362-4	2018	By single-molecule spectroscopy, we identify a conserved proline residue in NCBD (the nuclear-coactivator binding domain of CBP) whose cis/trans isomerization in the unbound state modulates the association and dissociation rates with its binding partner, ACTR.	Proline	57-64	CREB binding protein	Homo sapiens	124-127
29903888-2	2018	SRSF2 mutations cluster at proline 95, with the most frequent mutation being a histidine (P95H) substitution.	Proline	27-34	serine and arginine rich splicing factor 2	Homo sapiens	0-5
30006143-2	2018	Among them, compound 7b, which features an l-proline substituent, was identified as the strongest BTK inhibitor, with an IC50 of 8.7 nM.	Proline	43-52	Bruton tyrosine kinase	Homo sapiens	98-101
29752946-10	2018	The amino acids hydroxyproline, proline, lysine, glycine and alanine induced the triglyceride accumulation and expression of Adiponectin.	Proline	23-30	adiponectin, C1Q and collagen domain containing	Homo sapiens	125-136
29752946-12	2018	TGFbeta mRNA expression showed a significant decrease with proline, alanine, glycine, lysine and isoleucine.	Proline	59-66	transforming growth factor beta 1	Homo sapiens	0-7
29752946-14	2018	The UCP-2 gene showed a significant increase in proline and lysine treatment.	Proline	48-55	uncoupling protein 2	Homo sapiens	4-9
29752946-15	2018	DISCUSSION AND CONCLUSION: Our results suggest that amino acids hydroxyproline, proline, lysine, glycine and alanine which are elevated in the PDR vitreous show a tendency to induce adipogenic effects in retinal pericytes by triggering the accumulation of triglycerides and adiponectin.	Proline	71-78	adiponectin, C1Q and collagen domain containing	Homo sapiens	274-285
29907646-9	2018	RNAi functional testing of the top association and neuronal projection-related genes reveals that pros, pbl, ct, and CG33506 significantly modify age-related dopamine neuron loss and associated locomotor dysfunction in the Drosophila LRRK2 G2019S model.	Proline	98-102	Leucine-rich repeat kinase	Drosophila melanogaster	234-239
29847121-1	2018	A urea tag was incorporated at the C-4 position of proline, cis to its COOH group, in order to explore the prospect of a synergistic effect between the two functional groups in the transition state of the enamine route to the asymmetric aldol reaction.	Proline	51-58	complement C4A (Rodgers blood group)	Homo sapiens	35-38
29772247-6	2018	Preventing NF-M lysine-serine-proline (KSP) repeat phosphorylation increased internode length by 30% after remyelination.	Proline	30-37	neurofilament, medium polypeptide	Mus musculus	11-15
30058071-5	2018	An investigation into the interaction between the Shank SH3 domains and the proline-rich region of the Cav1.3 calcium channel revealed an atypical interaction in which the highly acidic specificity binding pocket of the SH3 domains binds to a Cav1.3 region containing a cluster of three Arg residues.	Proline	76-83	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	50-55
30058071-5	2018	An investigation into the interaction between the Shank SH3 domains and the proline-rich region of the Cav1.3 calcium channel revealed an atypical interaction in which the highly acidic specificity binding pocket of the SH3 domains binds to a Cav1.3 region containing a cluster of three Arg residues.	Proline	76-83	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	103-109
30058071-5	2018	An investigation into the interaction between the Shank SH3 domains and the proline-rich region of the Cav1.3 calcium channel revealed an atypical interaction in which the highly acidic specificity binding pocket of the SH3 domains binds to a Cav1.3 region containing a cluster of three Arg residues.	Proline	76-83	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	243-249
29381806-8	2018	Mechanistically, Pin1 recognizes and isomerizes the phosphorylated serine-proline motif of phosphorylated XPO5 and passivates phosphorylated XPO5.	Proline	74-81	exportin 5	Mus musculus	106-110
29398675-10	2018	apoE gene analysis revealed a T-to-C point mutation at amino acid 173 that caused a substitution of a proline residue for a leucine residue, which has not been reported previously.	Proline	102-109	apolipoprotein E	Homo sapiens	0-4
30288482-4	2018	Objective: This study was designed to examine associations of TP53 72 Arg&gt;Pro (rs1042522), and MDM2 309 T&gt;G (rs937283) polymorphisms with spermatogenetic failure in Iranian population.	Proline	77-80	tumor protein p53	Homo sapiens	62-66
30288482-6	2018	The two polymorphisms, 72 Arg&gt;Pro in TP53 and 309 T&gt;G in MDM2, were genotyped using PCR-RFLP and ARMS-PCR respectively.	Proline	33-36	tumor protein p53	Homo sapiens	40-44
29398675-17	2018	This case supports the hypothesis that the substitution of proline in or near the LDL receptor-binding area contributes to the development of LPG.	Proline	59-66	low density lipoprotein receptor	Homo sapiens	82-94
29288339-3	2018	Cdk5 is a proline-directed Ser/Thr kinase involved in the regulation of synaptic plasticity and memory processes that has been associated with several neurodegenerative disorders.	Proline	10-17	cyclin dependent kinase 5	Homo sapiens	0-4
29875238-8	2018	Finally, as we showed previously for other viruses that use TIM-1 for entry, a chimeric TIM-1 protein that substitutes the proline-rich region (PRR) from murine leukemia virus envelope (Env) for the mucin-like domain served as a competent receptor.	Proline	123-130	hepatitis A virus cellular receptor 1	Homo sapiens	88-93
30067985-0	2018	PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359.	Proline	54-61	egl-9 family hypoxia inducible factor 3	Homo sapiens	0-4
30067985-0	2018	PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359.	Proline	54-61	tumor protein p53	Homo sapiens	15-18
30067985-3	2018	Here, we show that PHD3 hydroxylates p53 at proline 359, a residue that is in the p53-DUB binding domain.	Proline	44-51	egl-9 family hypoxia inducible factor 3	Homo sapiens	19-23
30067985-3	2018	Here, we show that PHD3 hydroxylates p53 at proline 359, a residue that is in the p53-DUB binding domain.	Proline	44-51	tumor protein p53	Homo sapiens	37-40
30067985-3	2018	Here, we show that PHD3 hydroxylates p53 at proline 359, a residue that is in the p53-DUB binding domain.	Proline	44-51	tumor protein p53	Homo sapiens	82-85
30067985-4	2018	Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression.	Proline	26-33	tumor protein p53	Homo sapiens	17-20
30067985-4	2018	Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression.	Proline	26-33	ubiquitin specific peptidase 7	Homo sapiens	69-73
30053011-5	2018	Previously, we demonstrated that the alanine and proline-rich antigen (Apa), a secretory antigen of Map, could be detected in the intestine of cows with PTB using a monoclonal antibody.	Proline	49-56	glutamyl aminopeptidase	Bos taurus	71-74
30140255-4	2018	The in vitro results indicated that Pro-Gly, but not Pro plus Gly, promoted the expression and secretion of IGF-1 in HepG2.	Proline	36-39	insulin-like growth factor 1	Mus musculus	108-113
30067985-4	2018	Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression.	Proline	26-33	ubiquitin specific peptidase 10	Homo sapiens	78-83
30067985-4	2018	Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression.	Proline	26-33	tumor protein p53	Homo sapiens	133-136
30067985-4	2018	Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression.	Proline	26-33	ubiquitin specific peptidase 7	Homo sapiens	142-146
30067985-4	2018	Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression.	Proline	26-33	ubiquitin specific peptidase 10	Homo sapiens	147-152
30067985-4	2018	Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression.	Proline	26-33	tumor protein p53	Homo sapiens	133-136
30067985-4	2018	Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression.	Proline	26-33	tumor protein p53	Homo sapiens	133-136
29844040-0	2018	Fragments of the Nonlytic Proline-Rich Antimicrobial Peptide Bac5 Kill Escherichia coli Cells by Inhibiting Protein Synthesis.	Proline	26-33	cathelicidin-2	Bos taurus	61-65
30140255-9	2018	In agreement with the in vitro results, the in vivo findings demonstrated that Pro-Gly, but not Pro plus Gly, stimulated the expression and secretion of IGF-1 and activated JAK2/STAT5 signaling pathway in the liver of mice injected with Pro-Gly or Pro+Gly acutely or chronically.	Proline	79-82	insulin-like growth factor 1	Mus musculus	153-158
30140255-9	2018	In agreement with the in vitro results, the in vivo findings demonstrated that Pro-Gly, but not Pro plus Gly, stimulated the expression and secretion of IGF-1 and activated JAK2/STAT5 signaling pathway in the liver of mice injected with Pro-Gly or Pro+Gly acutely or chronically.	Proline	79-82	Janus kinase 2	Mus musculus	173-177
30140255-9	2018	In agreement with the in vitro results, the in vivo findings demonstrated that Pro-Gly, but not Pro plus Gly, stimulated the expression and secretion of IGF-1 and activated JAK2/STAT5 signaling pathway in the liver of mice injected with Pro-Gly or Pro+Gly acutely or chronically.	Proline	79-82	signal transducer and activator of transcription 5A	Mus musculus	178-183
29928795-4	2018	Results of GST pull-down and fluorescence polarization assays show that both a proline-rich SH3 binding motif (PSRPLPDAP, residues 466-474) and an adjacent phosphotyrosine-containing SH2 binding motif (pYEEI, residues 508-511) in Tks4 are responsible for Src binding.	Proline	79-86	SH3 and PX domains 2B	Homo sapiens	230-234
30022112-2	2018	Distinct intrinsically disordered regions (IDRs) in Drp1 substitute for the canonical pleckstrin homology (PH) domain and proline-rich domain (PRD) of prototypical dynamin, which cooperatively regulate endocytic vesicle scission.	Proline	122-129	dynamin 1 like	Homo sapiens	52-56
29928795-4	2018	Results of GST pull-down and fluorescence polarization assays show that both a proline-rich SH3 binding motif (PSRPLPDAP, residues 466-474) and an adjacent phosphotyrosine-containing SH2 binding motif (pYEEI, residues 508-511) in Tks4 are responsible for Src binding.	Proline	79-86	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	255-258
30011814-5	2018	Here we identified host WW-domain bearing protein BCL2 Associated Athanogene 3 (BAG3) as a LFV Z PPPY interactor using our proline-rich reading array of WW-domain containing mammalian proteins.	Proline	123-130	BAG cochaperone 3	Homo sapiens	50-78
30011814-5	2018	Here we identified host WW-domain bearing protein BCL2 Associated Athanogene 3 (BAG3) as a LFV Z PPPY interactor using our proline-rich reading array of WW-domain containing mammalian proteins.	Proline	123-130	BAG cochaperone 3	Homo sapiens	80-84
29678828-4	2018	We generated truncated forms of ROR1 and found the cytoplasmic proline-rich domain (PRD) of ROR1 was required for Wnt5a to induce ROR1 to complex with DOCK2 and activate Rac1/2 in the CLL cell-line MEC1.	Proline	63-70	receptor tyrosine kinase-like orphan receptor 1	Mus musculus	32-36
30100984-1	2018	The albumin D-box binding protein (DBP) is a member of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family and functions as important regulator of circadian core and output gene expression.	Proline	69-76	D site albumin promoter binding protein	Mus musculus	4-33
29678828-4	2018	We generated truncated forms of ROR1 and found the cytoplasmic proline-rich domain (PRD) of ROR1 was required for Wnt5a to induce ROR1 to complex with DOCK2 and activate Rac1/2 in the CLL cell-line MEC1.	Proline	63-70	receptor tyrosine kinase-like orphan receptor 1	Mus musculus	92-96
29678828-4	2018	We generated truncated forms of ROR1 and found the cytoplasmic proline-rich domain (PRD) of ROR1 was required for Wnt5a to induce ROR1 to complex with DOCK2 and activate Rac1/2 in the CLL cell-line MEC1.	Proline	63-70	wingless-type MMTV integration site family, member 5A	Mus musculus	114-119
29678828-4	2018	We generated truncated forms of ROR1 and found the cytoplasmic proline-rich domain (PRD) of ROR1 was required for Wnt5a to induce ROR1 to complex with DOCK2 and activate Rac1/2 in the CLL cell-line MEC1.	Proline	63-70	receptor tyrosine kinase-like orphan receptor 1	Mus musculus	92-96
30100984-1	2018	The albumin D-box binding protein (DBP) is a member of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family and functions as important regulator of circadian core and output gene expression.	Proline	69-76	D site albumin promoter binding protein	Mus musculus	35-38
29989547-4	2018	Conversely, low expression on lymphocytes is measured for three HLA-B allotypes that bind peptides with proline at position 2, which are disfavored by the transporter associated with antigen processing.	Proline	104-111	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	155-201
29961792-0	2018	Proline hydroxylation at different sites in hypoxia-inducible factor 1alpha modulates its interactions with the von Hippel-Lindau tumor suppressor protein.	Proline	0-7	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-75
29678828-4	2018	We generated truncated forms of ROR1 and found the cytoplasmic proline-rich domain (PRD) of ROR1 was required for Wnt5a to induce ROR1 to complex with DOCK2 and activate Rac1/2 in the CLL cell-line MEC1.	Proline	63-70	dedicator of cyto-kinesis 2	Mus musculus	151-156
29678828-4	2018	We generated truncated forms of ROR1 and found the cytoplasmic proline-rich domain (PRD) of ROR1 was required for Wnt5a to induce ROR1 to complex with DOCK2 and activate Rac1/2 in the CLL cell-line MEC1.	Proline	63-70	Rac family small GTPase 1	Mus musculus	170-174
29678828-5	2018	We introduced single amino acid substitutions of proline (P) to alanine (A) in the ROR1-PRD at potential binding sites for the Src-homology 3 domain of DOCK2.	Proline	49-56	receptor tyrosine kinase-like orphan receptor 1	Mus musculus	83-87
29678828-5	2018	We introduced single amino acid substitutions of proline (P) to alanine (A) in the ROR1-PRD at potential binding sites for the Src-homology 3 domain of DOCK2.	Proline	49-56	dedicator of cyto-kinesis 2	Mus musculus	152-157
29989547-4	2018	Conversely, low expression on lymphocytes is measured for three HLA-B allotypes that bind peptides with proline at position 2, which are disfavored by the transporter associated with antigen processing.	Proline	104-111	major histocompatibility complex, class I, B	Homo sapiens	64-69
29991577-4	2018	The patient was found to be heterozygous for c.2518C&gt;T (p.Pro840Ser), a likely damaging coding variant in the proline rich region of SHANK2 Interestingly, the patient"s disordered eating behaviour began to improve only after high-dose fluoxetine was initiated to target OCD symptoms.	Proline	113-120	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	136-142
29702134-4	2018	These SNPs are located in adjacent codons of the GRHL3 gene, and the occurrence of either SNP abolishes a putative threonine-proline phosphorylation motif at T454 in the encoded protein.	Proline	125-132	grainyhead like transcription factor 3	Homo sapiens	49-54
29800261-3	2018	TLS/FUS binding to G-quadruplex telomere DNA and telomeric repeat-containing RNA depends especially on RGG3, comprising Arg-Gly-Gly repeats with proline- and arginine-rich regions.	Proline	145-152	FUS RNA binding protein	Homo sapiens	0-3
29800261-3	2018	TLS/FUS binding to G-quadruplex telomere DNA and telomeric repeat-containing RNA depends especially on RGG3, comprising Arg-Gly-Gly repeats with proline- and arginine-rich regions.	Proline	145-152	FUS RNA binding protein	Homo sapiens	4-7
29800261-7	2018	Our findings suggest that the G-quadruplex-specific binding abilities of TLS/FUS require RGG3 with a beta-spiral structure stabilized by adjacent proline- and arginine-regions.	Proline	146-153	FUS RNA binding protein	Homo sapiens	73-76
29800261-7	2018	Our findings suggest that the G-quadruplex-specific binding abilities of TLS/FUS require RGG3 with a beta-spiral structure stabilized by adjacent proline- and arginine-regions.	Proline	146-153	FUS RNA binding protein	Homo sapiens	77-80
29845260-7	2018	Following gene sequencing, two novel heterozygous mutations of the FBN-1 gene were identified: c.3442C&gt;G in exon 27, proline replaced with alanine (p. Pro1148Ala) and c.6388G&gt;A in exon 52, glutamic acid replaced with lysine (p. Glu2130Lys).	Proline	120-127	fibrillin 1	Homo sapiens	67-72
29520916-0	2018	Identification and characterisation of a Theileria annulata proline-rich microtubule and SH3 domain-interacting protein (TaMISHIP) that forms a complex with CLASP1, EB1, and CD2AP at the schizont surface.	Proline	60-67	cytoplasmic linker associated protein 1	Bos taurus	157-163
29520916-0	2018	Identification and characterisation of a Theileria annulata proline-rich microtubule and SH3 domain-interacting protein (TaMISHIP) that forms a complex with CLASP1, EB1, and CD2AP at the schizont surface.	Proline	60-67	CD2 associated protein	Bos taurus	174-179
29734505-4	2018	By co-immunoprecipitation and anti-phosphotyrosine blotting, we identified proline-rich binding sites for Fyn kinase in the N-terminal, IC-loopi-ii and C-terminal.	Proline	75-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-109
28770354-6	2018	The negative regulation of SOX9 transcriptional activity by THRAP3 was mediated by interaction between the proline-, glutamine-, and serine-rich domain of SOX9 and the innominate domain of THRAP3.	Proline	107-114	SRY (sex determining region Y)-box 9	Mus musculus	27-31
28770354-6	2018	The negative regulation of SOX9 transcriptional activity by THRAP3 was mediated by interaction between the proline-, glutamine-, and serine-rich domain of SOX9 and the innominate domain of THRAP3.	Proline	107-114	thyroid hormone receptor associated protein 3	Mus musculus	60-66
28770354-6	2018	The negative regulation of SOX9 transcriptional activity by THRAP3 was mediated by interaction between the proline-, glutamine-, and serine-rich domain of SOX9 and the innominate domain of THRAP3.	Proline	107-114	SRY (sex determining region Y)-box 9	Mus musculus	155-159
28770354-6	2018	The negative regulation of SOX9 transcriptional activity by THRAP3 was mediated by interaction between the proline-, glutamine-, and serine-rich domain of SOX9 and the innominate domain of THRAP3.	Proline	107-114	thyroid hormone receptor associated protein 3	Mus musculus	189-195
29915297-5	2018	We report the discovery of a conserved proline-rich motif in LAT that mediates efficient LAT phosphorylation.	Proline	39-46	linker for activation of T cells	Homo sapiens	61-64
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Proline	89-96	pyrroline-5-carboxylate reductase 1	Homo sapiens	59-67
29915297-5	2018	We report the discovery of a conserved proline-rich motif in LAT that mediates efficient LAT phosphorylation.	Proline	39-46	linker for activation of T cells	Homo sapiens	89-92
29915297-7	2018	Elimination of this proline-rich motif compromises TCR signaling and T cell development.	Proline	20-27	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	51-54
30042616-8	2018	Over-expression of CBF1 increased the level of COR (cold-regulated) gene transcripts in OE lines, and the physiological indexes related to cold tolerance like the contents of SOD, soluble protein, MDA, proline and soluble sugar were higher in OE lines than in WT except RWC which was lower.	Proline	202-209	CBF2	Solanum tuberosum	19-23
30240740-3	2018	The phosphorylation sites were highly proline directed and primarily MAPK dependent, owing to the activation of JNK, suggesting that proteins that undergo proline-directed phosphorylation mediate nerve growth in the mammalian brain.	Proline	38-45	mitogen-activated protein kinase 8	Homo sapiens	112-115
30240740-3	2018	The phosphorylation sites were highly proline directed and primarily MAPK dependent, owing to the activation of JNK, suggesting that proteins that undergo proline-directed phosphorylation mediate nerve growth in the mammalian brain.	Proline	155-162	mitogen-activated protein kinase 8	Homo sapiens	112-115
29648801-2	2018	Proline biosynthesis and degradation involve the shared intermediate Delta1-pyrroline-5-carboxylate (P5C), which forms l-glutamate-gamma-semialdehyde (GSAL) in a reversible non-enzymatic reaction.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	75-99
29648801-2	2018	Proline biosynthesis and degradation involve the shared intermediate Delta1-pyrroline-5-carboxylate (P5C), which forms l-glutamate-gamma-semialdehyde (GSAL) in a reversible non-enzymatic reaction.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	101-104
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	59-67
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Proline	89-96	pyrroline-5-carboxylate reductase 1	Homo sapiens	64-67
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Proline	89-96	pyrroline-5-carboxylate reductase 1	Homo sapiens	115-119
29648801-4	2018	The degradation of proline occurs in the mitochondrion and involves two oxidative steps catalyzed by proline dehydrogenase (PRODH) and GSAL dehydrogenase (GSALDH).	Proline	19-26	proline dehydrogenase 1	Homo sapiens	101-122
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	64-67
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	115-119
29648801-4	2018	The degradation of proline occurs in the mitochondrion and involves two oxidative steps catalyzed by proline dehydrogenase (PRODH) and GSAL dehydrogenase (GSALDH).	Proline	19-26	proline dehydrogenase 1	Homo sapiens	124-129
29949777-6	2018	DFR1 interacts with proline degradation enzymes PDH1/2 and P5CDH and compromises their activities.	Proline	20-27	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	48-54
29648801-5	2018	PRODH is a flavin-dependent enzyme that couples proline oxidation with reduction of membrane-bound quinone, while GSALDH catalyzes the NAD+-dependent oxidation of GSAL to glutamate.	Proline	48-55	proline dehydrogenase 1	Homo sapiens	0-5
29648801-6	2018	PRODH and PYCR form a metabolic relationship known as the proline-P5C cycle, a novel pathway that impacts cellular growth and death pathways.	Proline	58-65	proline dehydrogenase 1	Homo sapiens	0-5
29648801-6	2018	PRODH and PYCR form a metabolic relationship known as the proline-P5C cycle, a novel pathway that impacts cellular growth and death pathways.	Proline	58-65	pyrroline-5-carboxylate reductase 1	Homo sapiens	10-14
29949777-6	2018	DFR1 interacts with proline degradation enzymes PDH1/2 and P5CDH and compromises their activities.	Proline	20-27	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	59-64
29949777-7	2018	Genetic analysis showed that DFR1 acts upstream of PDH1/2 and P5CDH to positively regulate proline accumulation.	Proline	91-98	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	62-67
29648801-6	2018	PRODH and PYCR form a metabolic relationship known as the proline-P5C cycle, a novel pathway that impacts cellular growth and death pathways.	Proline	58-65	pyrroline-5-carboxylate reductase 1	Homo sapiens	66-69
29949777-8	2018	Our results demonstrate a regulatory mechanism by which, under drought and freezing stresses, DFR1 interacts with PDH1/2 and P5CDH to abrogate their activities to maintain proline homeostasis, thereby conferring drought and freezing tolerance.	Proline	172-179	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	114-120
29949777-7	2018	Genetic analysis showed that DFR1 acts upstream of PDH1/2 and P5CDH to positively regulate proline accumulation.	Proline	91-98	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	51-57
29648801-7	2018	The proline-P5C cycle has been implicated in supporting ATP production, protein and nucleotide synthesis, anaplerosis, and redox homeostasis in cancer cells.	Proline	4-11	pyrroline-5-carboxylate reductase 1	Homo sapiens	12-15
29949777-8	2018	Our results demonstrate a regulatory mechanism by which, under drought and freezing stresses, DFR1 interacts with PDH1/2 and P5CDH to abrogate their activities to maintain proline homeostasis, thereby conferring drought and freezing tolerance.	Proline	172-179	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	125-130
29648801-8	2018	This Perspective details the structures and reaction mechanisms of PRODH and PYCR and the role of the proline-P5C cycle in cancer metabolism.	Proline	102-109	pyrroline-5-carboxylate reductase 1	Homo sapiens	110-113
29648801-9	2018	A major challenge in the field is to discover inhibitors that specifically target PRODH and PYCR isoforms for use as tools for studying proline metabolism and the functions of the proline-P5C cycle in cancer.	Proline	136-143	proline dehydrogenase 1	Homo sapiens	82-87
29648801-9	2018	A major challenge in the field is to discover inhibitors that specifically target PRODH and PYCR isoforms for use as tools for studying proline metabolism and the functions of the proline-P5C cycle in cancer.	Proline	136-143	pyrroline-5-carboxylate reductase 1	Homo sapiens	92-96
29648801-9	2018	A major challenge in the field is to discover inhibitors that specifically target PRODH and PYCR isoforms for use as tools for studying proline metabolism and the functions of the proline-P5C cycle in cancer.	Proline	180-187	proline dehydrogenase 1	Homo sapiens	82-87
29648801-9	2018	A major challenge in the field is to discover inhibitors that specifically target PRODH and PYCR isoforms for use as tools for studying proline metabolism and the functions of the proline-P5C cycle in cancer.	Proline	180-187	pyrroline-5-carboxylate reductase 1	Homo sapiens	188-191
29648801-10	2018	These molecular probes could also serve as lead compounds in cancer drug discovery targeting the proline-P5C cycle.	Proline	97-104	pyrroline-5-carboxylate reductase 1	Homo sapiens	105-108
29988361-9	2018	Within the CDR3, proline and cysteine undergo negative selection, while glycine undergoes positive selection.	Proline	17-24	cerebellar degeneration-related 3	Mus musculus	11-15
29936711-4	2018	Researchers observed thata protective genetic variant TP53 codon 72 proline allele was more commonly found in this population and appear tobe over-transmitted compared to others known for their high rate of cervical cancer.	Proline	68-75	tumor protein p53	Homo sapiens	54-58
29963014-6	2018	The DPP-IV half maximal inhibitory concentration (IC50) values of the 25 peptides evaluated ranged from 3.9 +- 1.0 microM (Ile-Pro-Ile) to 247.0 +- 32.7 microM (Phe-Pro-Phe).	Proline	127-130	dipeptidyl peptidase 4	Homo sapiens	4-10
29963014-6	2018	The DPP-IV half maximal inhibitory concentration (IC50) values of the 25 peptides evaluated ranged from 3.9 +- 1.0 microM (Ile-Pro-Ile) to 247.0 +- 32.7 microM (Phe-Pro-Phe).	Proline	165-168	dipeptidyl peptidase 4	Homo sapiens	4-10
30026827-12	2018	Splicing factor proline and glutamine rich (SFPQ), a novel RNA binding protein, was identified as a direct target gene of miR-1296 in CRC.	Proline	16-23	splicing factor proline and glutamine rich	Homo sapiens	44-48
29789853-2	2018	Short Aib-Pro peptides showed slightly higher ET rates due to the better electronic coupling of the Pro residue.	Proline	10-13	ANIB1	Homo sapiens	6-9
30026827-12	2018	Splicing factor proline and glutamine rich (SFPQ), a novel RNA binding protein, was identified as a direct target gene of miR-1296 in CRC.	Proline	16-23	microRNA 1296	Homo sapiens	122-130
29545197-4	2018	Cre recombination generates a permanent Notch2DeltaPEST allele expressing a transcript for which sequences coding for the proline, glutamic acid, serine, and threonine-rich (PEST) domain are replaced by a stop codon.	Proline	122-129	notch 2	Mus musculus	40-46
29610151-6	2018	Essential for the full hnRNP L effect on specific exons is a proline-rich region that emerged during evolution in vertebrate hnRNP L only but not LL.	Proline	61-68	heterogeneous nuclear ribonucleoprotein L	Rattus norvegicus	23-30
29567535-0	2018	Nanobodies targeting cortactin proline rich, helical and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells.	Proline	31-38	cortactin	Homo sapiens	21-30
29567535-7	2018	One nanobody interacts with the actin binding repeats whereas the other targets the proline rich region and was found to reduce EGF-induced cortactin phosphorylation.	Proline	84-91	cortactin	Homo sapiens	140-149
28864347-1	2018	BAG3 is a multifunctional protein that can bind to heat shock proteins (Hsp) 70 through its BAG domain and to other partners through its WW domain, proline-rich (PXXP) repeat and IPV (Ile-Pro-Val) motifs.	Proline	148-155	BAG cochaperone 3	Homo sapiens	0-4
29849110-3	2018	In this research we report a FRalpha binding peptide C7(Met-His-Thr-Ala-Pro-Gly-Trp-Gly-Tyr-Arg-Leu-Ser) discovered by phage display and this peptide showed specific binding to FRalpha expressing cells by cell ELISA and flow cytometry.	Proline	72-75	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	29-36
29849110-3	2018	In this research we report a FRalpha binding peptide C7(Met-His-Thr-Ala-Pro-Gly-Trp-Gly-Tyr-Arg-Leu-Ser) discovered by phage display and this peptide showed specific binding to FRalpha expressing cells by cell ELISA and flow cytometry.	Proline	72-75	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	177-184
29856862-6	2018	ZmPIP1;1 overexpression plants showed higher activities of reactive oxygen species (ROS) scavenging enzymes such as catalase and superoxide dismutase, lower contents of stress-induced ROS such as superoxide, hydrogen peroxide and malondialdehyde, and higher levels of proline under drought and salt stress than did wild type.	Proline	268-275	aquaporin PIP1-1	Zea mays	0-8
29610151-6	2018	Essential for the full hnRNP L effect on specific exons is a proline-rich region that emerged during evolution in vertebrate hnRNP L only but not LL.	Proline	61-68	heterogeneous nuclear ribonucleoprotein L	Rattus norvegicus	125-132
29561231-6	2018	Interestingly, after deletion of six proline residues from position 26 to 31 in the N-terminus, expression of recombinant GPC3 was clearly detected.	Proline	37-44	glypican 3	Homo sapiens	122-126
29626154-2	2018	We previously reported that an OPN mutant lacking five O-glycosylation sites (Thr134/Thr138/Thr143/Thr147/Thr152) in the threonine/proline-rich region increased cell adhesion activity and phosphorylation compared with the wild type.	Proline	131-138	secreted phosphoprotein 1	Homo sapiens	31-34
29754822-4	2018	We found that huntingtin exon1 proteins can form reversible liquid-like assemblies, a process driven by huntingtin"s polyQ tract and proline-rich region.	Proline	133-140	huntingtin	Homo sapiens	14-24
29458167-7	2018	The results of sequencing revealed a missense, heterozygous mutation of IL17F, converting a threonine to proline in a patient with RAS (T79P).	Proline	105-112	interleukin 17F	Homo sapiens	72-77
29500169-5	2018	Concurrently, Src homology domain-containing transforming protein 1 (SHC1) recruits the PP2A scaffolding subunit to the proline-rich apoER2 C terminus along with 2 distinct regulatory PP2A subunits that mediate inhibitory dephosphorylation of Akt and eNOS.	Proline	120-127	src homology 2 domain-containing transforming protein C1	Mus musculus	69-73
29500169-5	2018	Concurrently, Src homology domain-containing transforming protein 1 (SHC1) recruits the PP2A scaffolding subunit to the proline-rich apoER2 C terminus along with 2 distinct regulatory PP2A subunits that mediate inhibitory dephosphorylation of Akt and eNOS.	Proline	120-127	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	88-92
29500169-5	2018	Concurrently, Src homology domain-containing transforming protein 1 (SHC1) recruits the PP2A scaffolding subunit to the proline-rich apoER2 C terminus along with 2 distinct regulatory PP2A subunits that mediate inhibitory dephosphorylation of Akt and eNOS.	Proline	120-127	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	Mus musculus	133-139
29626154-4	2018	Here, we show that site-specific O-glycosylation in the threonine/proline-rich region of OPN affects its cell adhesion activity and phosphorylation independently and/or synergistically.	Proline	66-73	secreted phosphoprotein 1	Homo sapiens	89-92
29511087-8	2018	The alanine-scanning experiments revealed that residues Tyr-34, Gln-38, Gly-39, and Leu-45 (in the AB loop) and Pro-153 (in the D-helix) had specific roles in activating OSMR but not LIFR signaling, whereas Leu-40 and Cys-49 (in the AB loop), and Phe-160 and Lys-163 (in the D-helix) were required for activation of both receptors.	Proline	112-115	oncostatin M receptor	Homo sapiens	170-174
29511087-8	2018	The alanine-scanning experiments revealed that residues Tyr-34, Gln-38, Gly-39, and Leu-45 (in the AB loop) and Pro-153 (in the D-helix) had specific roles in activating OSMR but not LIFR signaling, whereas Leu-40 and Cys-49 (in the AB loop), and Phe-160 and Lys-163 (in the D-helix) were required for activation of both receptors.	Proline	112-115	LIF receptor subunit alpha	Homo sapiens	183-187
29607917-5	2018	Gene analysis revealed an arginine-to-proline missense mutation in the NOTCH3 gene at codon 75.	Proline	38-45	notch receptor 3	Homo sapiens	71-77
29632410-2	2018	GID4, a subunit of the ubiquitin ligase GID complex, has been recently identified as the N-recognin of the new branch of the N-end rule pathway responsible for recognizing substrates bearing N-terminal proline residues (Pro/N-degrons).	Proline	202-209	GID complex subunit 4 homolog	Homo sapiens	0-4
29576081-3	2018	Screening of T-DNA knockout mutants for resistance to the proline analogue thioproline (T4C), identified mutant alleles of the plant SELO homologue in Arabidopsis thaliana.	Proline	58-65	selenoprotein O	Arabidopsis thaliana	133-137
29576081-4	2018	Absence of SELO resulted in a stress-induced transcriptional activation instead of silencing of mitochondrial proline dehydrogenase, and also high elevation of Delta(1)-pyrroline-5-carboxylate dehydrogenase involved in degradation of proline, thereby alleviating T4C inhibition and lessening drought-induced proline accumulation.	Proline	110-117	selenoprotein O	Arabidopsis thaliana	11-15
29576081-4	2018	Absence of SELO resulted in a stress-induced transcriptional activation instead of silencing of mitochondrial proline dehydrogenase, and also high elevation of Delta(1)-pyrroline-5-carboxylate dehydrogenase involved in degradation of proline, thereby alleviating T4C inhibition and lessening drought-induced proline accumulation.	Proline	234-241	selenoprotein O	Arabidopsis thaliana	11-15
29576081-4	2018	Absence of SELO resulted in a stress-induced transcriptional activation instead of silencing of mitochondrial proline dehydrogenase, and also high elevation of Delta(1)-pyrroline-5-carboxylate dehydrogenase involved in degradation of proline, thereby alleviating T4C inhibition and lessening drought-induced proline accumulation.	Proline	234-241	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	160-206
29755973-5	2018	Substitution of residues in loop D with proline showed effects on ion conductance amplitude that varied with position, suggesting that the structural conformation of loop D is important for AQP1 channel gating.	Proline	40-47	aquaporin 1 (Colton blood group)	Homo sapiens	190-194
29765472-4	2018	Therefore, we developed novel cyclic NGR peptide-daunomycin conjugates in which Lys was replaced by different amino acids (Ala, Leu, Nle, Pro, Ser).	Proline	138-141	reticulon 4 receptor	Homo sapiens	37-40
28585188-6	2018	The effects of proline and LPS in the cerebral cortex and cerebellum on the expression of S100B and GFAP, oxidative stress parameters, enzymes of phosphoryl transfer network activity, and mitochondrial respiration chain complexes were investigated.	Proline	15-22	S100 calcium binding protein B	Rattus norvegicus	90-95
29247897-4	2018	Several studies have shown that MIF is subject to post-translational modification, particularly redox-dependent modification of the catalytic proline and cysteine residues.	Proline	142-149	macrophage migration inhibitory factor	Homo sapiens	32-35
29494882-4	2018	Specifically, the minor G-allele of the SNP, which encodes proline instead of leucine and leads to higher processing of pre-pro NPY into mature NPY, was associated with higher levels of conscientiousness.	Proline	59-66	neuropeptide Y	Homo sapiens	128-131
29494882-4	2018	Specifically, the minor G-allele of the SNP, which encodes proline instead of leucine and leads to higher processing of pre-pro NPY into mature NPY, was associated with higher levels of conscientiousness.	Proline	59-66	neuropeptide Y	Homo sapiens	144-147
29507106-0	2018	The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability.	Proline	24-31	ceramide synthase 5	Homo sapiens	113-117
29595969-0	2018	Proline Restricts Loop I Conformation of the High Affinity WW Domain from Human Nedd4-1 to a Ligand Binding-Competent Type I beta-Turn.	Proline	0-7	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	80-87
29731721-7	2018	Mechanistically, AIP1 via its proline-rich region binds to the SH3 domain of cytosolic subunit p47phox to disrupt formation of an active NOX2 complex, attenuating ROS production.	Proline	30-37	disabled 2 interacting protein	Mus musculus	17-21
29731721-7	2018	Mechanistically, AIP1 via its proline-rich region binds to the SH3 domain of cytosolic subunit p47phox to disrupt formation of an active NOX2 complex, attenuating ROS production.	Proline	30-37	cytochrome b-245, beta polypeptide	Mus musculus	137-141
29731721-11	2018	AIP1 via its proline-rich region binds to the SH3 domain of cytosolic subunit p47phox to disrupt formation of an active NOX2 complex, attenuating ROS production.	Proline	13-20	disabled 2 interacting protein	Mus musculus	0-4
29731721-11	2018	AIP1 via its proline-rich region binds to the SH3 domain of cytosolic subunit p47phox to disrupt formation of an active NOX2 complex, attenuating ROS production.	Proline	13-20	cytochrome b-245, beta polypeptide	Mus musculus	120-124
29677513-5	2018	This activity depends on tight binding of karyopherin-beta2 to the C-terminal proline-tyrosine nuclear localization signal (PY-NLS) of FUS.	Proline	78-85	transportin 1	Homo sapiens	42-59
29677513-5	2018	This activity depends on tight binding of karyopherin-beta2 to the C-terminal proline-tyrosine nuclear localization signal (PY-NLS) of FUS.	Proline	78-85	FUS RNA binding protein	Homo sapiens	135-138
29507106-4	2018	In this study, we demonstrate that substitution of the nonanchoring position 3 into a proline residue of the first identified TEIPP peptide, the murine Trh4, results in significantly enhanced recognition by antitumor CTLs toward the wild-type epitope.	Proline	86-93	ceramide synthase 5	Mus musculus	152-156
29655366-11	2018	We also observed that a proline substitution at the P3 position eliminated the ability of p6*-deleted Gag-Pol to mediate virus maturation, thus emphasizing the importance of C-terminal p6* residues to modulating PR activation.	Proline	24-31	exosome component 9	Homo sapiens	90-93
29655366-11	2018	We also observed that a proline substitution at the P3 position eliminated the ability of p6*-deleted Gag-Pol to mediate virus maturation, thus emphasizing the importance of C-terminal p6* residues to modulating PR activation.	Proline	24-31	Gag-Pol	Human immunodeficiency virus 1	102-109
29655366-11	2018	We also observed that a proline substitution at the P3 position eliminated the ability of p6*-deleted Gag-Pol to mediate virus maturation, thus emphasizing the importance of C-terminal p6* residues to modulating PR activation.	Proline	24-31	exosome component 9	Homo sapiens	185-188
29581290-1	2018	The with-no-lysine (K) (WNK) signaling pathway to STE20/SPS1-related proline- and alanine-rich kinase (SPAK) and oxidative stress-responsive 1 (OSR1) kinase is an important mediator of cell volume and ion transport.	Proline	69-76	serine/threonine kinase 24	Homo sapiens	50-55
29642034-7	2018	An alanine at position 164 of cTnI is conserved in all mammals, with the exception of the platypus, which expresses a proline.	Proline	118-125	troponin I3, cardiac type	Rattus norvegicus	30-34
29642034-11	2018	Substitution of a proline at position 164 of cTnI in adult rat cardiac myocytes causes increased contractility independent of alterations in the Ca2+ transient.	Proline	18-25	troponin I3, cardiac type	Rattus norvegicus	45-49
29471051-8	2018	ORF3 mutants with proline-to-leucine mutations at amino acids (aa) 93, 96 and/or 98 in ORF3 were constructed and transfected into PLC/PRF/5 cells.	Proline	18-25	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	0-4
29394377-0	2018	Overexpression of lily HsfA3s in Arabidopsis confers increased thermotolerance and salt sensitivity via alterations in proline catabolism.	Proline	119-126	heat shock transcription factor A3	Arabidopsis thaliana	23-28
29681857-2	2018	Here, we examined the potential effect of a synthetic peptide derived from the leucine zipper motif and proline-rich region of GILZ on suppressing inflammatory responses in primary cultured rat Muller cells.	Proline	104-111	TSC22 domain family, member 3	Rattus norvegicus	127-131
29576217-4	2018	EPRS is a bifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species.	Proline	104-111	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	0-4
29535192-2	2018	A proline mutation in the central integrin beta3 transmembrane domain (TMD) creates a flexible kink that uncouples the topology of the inner half of the TMD from the outer half.	Proline	2-9	integrin subunit beta 3	Homo sapiens	34-48
29681859-7	2018	These data suggest that polyphenols of propolis induce PRODH/POX-dependent apoptosis through up-regulation of mitochondrial proline degradation and down-regulation of proline utilization for collagen biosynthesis.	Proline	124-131	proline dehydrogenase 1	Homo sapiens	55-60
29681859-7	2018	These data suggest that polyphenols of propolis induce PRODH/POX-dependent apoptosis through up-regulation of mitochondrial proline degradation and down-regulation of proline utilization for collagen biosynthesis.	Proline	124-131	proline dehydrogenase 1	Homo sapiens	61-64
29681859-7	2018	These data suggest that polyphenols of propolis induce PRODH/POX-dependent apoptosis through up-regulation of mitochondrial proline degradation and down-regulation of proline utilization for collagen biosynthesis.	Proline	167-174	proline dehydrogenase 1	Homo sapiens	55-60
29471051-10	2018	In conclusion, the ORF3 protein, especially its proline residues at aa 93 and 96, is essential for the release of membrane-associated ratHEV particles, and ORF4 is unnecessary for the replication of ratHEV.	Proline	48-55	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	19-23
29367257-3	2018	The preserved binding orientation proposed for full-length PYY and five analogs, truncated at the amino terminus, explains our pharmacological results where truncations of the N-terminal proline helix showed little effect on peptide affinity.	Proline	187-194	peptide YY	Homo sapiens	59-62
29348189-1	2018	Proline, glutamic acid, leucine-rich protein 1 (PELP1) is overexpressed in approximately 80% of invasive breast tumors.	Proline	0-7	proline, glutamic acid and leucine rich protein 1	Mus musculus	48-53
29528226-6	2018	Our results indicated that SlMYC2 might be involved in MeJA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels.	Proline	167-174	transcription factor MYC2	Solanum lycopersicum	27-33
29261364-1	2018	BACKGROUND: The TP53 codon 72 Proline-Arginine polymorphism (TP53 P72R) is the most widely studied candidate among those evaluated for a putative association between impaired apoptosis and glaucoma.	Proline	30-37	tumor protein p53	Homo sapiens	16-20
29261364-1	2018	BACKGROUND: The TP53 codon 72 Proline-Arginine polymorphism (TP53 P72R) is the most widely studied candidate among those evaluated for a putative association between impaired apoptosis and glaucoma.	Proline	30-37	tumor protein p53	Homo sapiens	61-65
29596499-9	2018	We identified and confirmed three specific proteins of interest; filamin A, heat shock protein 90beta (HSP90beta), and bifunctional glutamate/proline-tRNA ligase (EPRS), that were selectively carbonylated in tumor tissue compared to matched adjacent healthy tissue.	Proline	142-149	filamin A	Homo sapiens	65-74
29596499-9	2018	We identified and confirmed three specific proteins of interest; filamin A, heat shock protein 90beta (HSP90beta), and bifunctional glutamate/proline-tRNA ligase (EPRS), that were selectively carbonylated in tumor tissue compared to matched adjacent healthy tissue.	Proline	142-149	heat shock protein 90 alpha family class B member 1	Homo sapiens	103-112
29596499-9	2018	We identified and confirmed three specific proteins of interest; filamin A, heat shock protein 90beta (HSP90beta), and bifunctional glutamate/proline-tRNA ligase (EPRS), that were selectively carbonylated in tumor tissue compared to matched adjacent healthy tissue.	Proline	142-149	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	163-167
29196259-4	2018	The reduced or elevated tolerance of cpk1 mutant and AtCPK1-overexpressing lines was confirmed by the changes of proline, malondialdehyde (MDA) and H2O2.	Proline	113-120	calcium dependent protein kinase 1	Arabidopsis thaliana	37-41
29196259-4	2018	The reduced or elevated tolerance of cpk1 mutant and AtCPK1-overexpressing lines was confirmed by the changes of proline, malondialdehyde (MDA) and H2O2.	Proline	113-120	calcium dependent protein kinase 1	Arabidopsis thaliana	53-59
29557783-3	2018	In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele has a weaker p53 activity and function in tumor suppression.	Proline	78-85	DEAD-box helicase 17	Homo sapiens	87-90
29557783-3	2018	In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele has a weaker p53 activity and function in tumor suppression.	Proline	78-85	tumor protein p53	Homo sapiens	115-118
29562167-0	2018	Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.	Proline	42-49	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	10-14
29562167-0	2018	Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.	Proline	42-49	pyrroline-5-carboxylate reductase 1	Homo sapiens	68-73
29557783-3	2018	In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele has a weaker p53 activity and function in tumor suppression.	Proline	78-85	DEAD-box helicase 17	Homo sapiens	133-136
29562167-4	2018	By virtue of a change in cellular redox homeostasis, IDH1-mutated cells synthesize excess glutamine-derived proline through enhanced activity of pyrroline 5-carboxylate reductase 1 (PYCR1), coupled to NADH oxidation.	Proline	108-115	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	53-57
29557783-3	2018	In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele has a weaker p53 activity and function in tumor suppression.	Proline	78-85	tumor protein p53	Homo sapiens	157-160
29562167-4	2018	By virtue of a change in cellular redox homeostasis, IDH1-mutated cells synthesize excess glutamine-derived proline through enhanced activity of pyrroline 5-carboxylate reductase 1 (PYCR1), coupled to NADH oxidation.	Proline	108-115	pyrroline-5-carboxylate reductase 1	Homo sapiens	145-180
29562167-4	2018	By virtue of a change in cellular redox homeostasis, IDH1-mutated cells synthesize excess glutamine-derived proline through enhanced activity of pyrroline 5-carboxylate reductase 1 (PYCR1), coupled to NADH oxidation.	Proline	108-115	pyrroline-5-carboxylate reductase 1	Homo sapiens	182-187
29461832-2	2018	We find that the alanine-rich cross-linking domains of elastin have a partially helical structure, but only when capped by proline-rich hydrophobic domains.	Proline	123-130	elastin	Homo sapiens	55-62
29440552-2	2018	From analysis of newly identified human hyperekplexia mutations in the glycine receptor (GlyR) alpha1 subunit, we found that an alanine-to-proline missense mutation (A384P) resulted in substantially higher desensitization level and lower agonist sensitivity of homomeric alpha1 GlyRs when expressed in HEK cells.	Proline	139-146	glycine receptor alpha 1	Homo sapiens	71-101
29489342-7	2018	When this method was applied to the proline-rich region of B cell adaptor protein SLP-65 (pH 6.0) and alpha-synuclein (pH 7.4), which contain a total of 52 and 5 prolines, respectively, 99% and 92% of their nonprolyl amide resonances have been successfully assigned, demonstrating its robustness to address the assignment problem in large proline-rich IDPs.	Proline	36-43	B cell linker	Homo sapiens	82-88
29489342-7	2018	When this method was applied to the proline-rich region of B cell adaptor protein SLP-65 (pH 6.0) and alpha-synuclein (pH 7.4), which contain a total of 52 and 5 prolines, respectively, 99% and 92% of their nonprolyl amide resonances have been successfully assigned, demonstrating its robustness to address the assignment problem in large proline-rich IDPs.	Proline	36-43	synuclein alpha	Homo sapiens	102-117
29489342-7	2018	When this method was applied to the proline-rich region of B cell adaptor protein SLP-65 (pH 6.0) and alpha-synuclein (pH 7.4), which contain a total of 52 and 5 prolines, respectively, 99% and 92% of their nonprolyl amide resonances have been successfully assigned, demonstrating its robustness to address the assignment problem in large proline-rich IDPs.	Proline	162-170	B cell linker	Homo sapiens	82-88
29489342-7	2018	When this method was applied to the proline-rich region of B cell adaptor protein SLP-65 (pH 6.0) and alpha-synuclein (pH 7.4), which contain a total of 52 and 5 prolines, respectively, 99% and 92% of their nonprolyl amide resonances have been successfully assigned, demonstrating its robustness to address the assignment problem in large proline-rich IDPs.	Proline	162-170	synuclein alpha	Homo sapiens	102-117
29489342-7	2018	When this method was applied to the proline-rich region of B cell adaptor protein SLP-65 (pH 6.0) and alpha-synuclein (pH 7.4), which contain a total of 52 and 5 prolines, respectively, 99% and 92% of their nonprolyl amide resonances have been successfully assigned, demonstrating its robustness to address the assignment problem in large proline-rich IDPs.	Proline	162-169	B cell linker	Homo sapiens	82-88
29489342-7	2018	When this method was applied to the proline-rich region of B cell adaptor protein SLP-65 (pH 6.0) and alpha-synuclein (pH 7.4), which contain a total of 52 and 5 prolines, respectively, 99% and 92% of their nonprolyl amide resonances have been successfully assigned, demonstrating its robustness to address the assignment problem in large proline-rich IDPs.	Proline	162-169	synuclein alpha	Homo sapiens	102-117
29540686-3	2018	Here, we show that a single amino acid variant within the C-terminal proline-rich motif of human and mouse CD28 (P212 in human vs. A210 in mouse) regulates CD28-induced NF-kappaB activation and pro-inflammatory cytokine gene expression.	Proline	69-76	CD28 antigen	Mus musculus	107-111
29540686-3	2018	Here, we show that a single amino acid variant within the C-terminal proline-rich motif of human and mouse CD28 (P212 in human vs. A210 in mouse) regulates CD28-induced NF-kappaB activation and pro-inflammatory cytokine gene expression.	Proline	69-76	CD28 antigen	Mus musculus	156-160
29440552-2	2018	From analysis of newly identified human hyperekplexia mutations in the glycine receptor (GlyR) alpha1 subunit, we found that an alanine-to-proline missense mutation (A384P) resulted in substantially higher desensitization level and lower agonist sensitivity of homomeric alpha1 GlyRs when expressed in HEK cells.	Proline	139-146	glycine receptor alpha 1	Homo sapiens	271-283
29440552-8	2018	Together, our findings demonstrate that A384 is associated with the desensitization site of the alpha1 subunit and its proline mutation produced enhanced desensitization of GlyRs, which contributes to the pathogenesis of human hyperekplexia.SIGNIFICANCE STATEMENT Human startle disease is caused by impaired synaptic inhibition in the brainstem and spinal cord, which is due to either direct loss of GlyR channel function or reduced number of synaptic GlyRs.	Proline	119-126	adrenoceptor alpha 1D	Homo sapiens	96-102
29278770-7	2018	Phenotypic and physiological identification showed that Tip2;2 loss-of-function mutant exhibited less sensitive to abiotic stresses (mannitol, NaCl and PEG) compared with wild-type, as evident by analysis of germination rate, root growth, survival rate, ion leakage, malondialdehyde (MDA) and proline contents.	Proline	293-300	tonoplast intrinsic protein 2	Arabidopsis thaliana	56-60
29120856-7	2018	The variant genotype of PPARgamma CG (Pro/Ala) was associated with significantly higher levels of total cholesterol and triglycerides compared to CC (Pro/Pro) genotype.	Proline	38-41	peroxisome proliferator activated receptor gamma	Homo sapiens	24-33
29358329-5	2018	We confirm that profilin achieves its cellular effects through direct binding to the C-terminal proline-rich region of Htt-NTFs.	Proline	96-103	huntingtin	Homo sapiens	119-122
29564399-8	2018	The regulators PUT3 and UGA3 are required for metabolism of proline and gamma-aminobutyric acid (GABA), respectively.	Proline	60-67	Put3p	Saccharomyces cerevisiae S288C	15-19
29564399-8	2018	The regulators PUT3 and UGA3 are required for metabolism of proline and gamma-aminobutyric acid (GABA), respectively.	Proline	60-67	Uga3p	Saccharomyces cerevisiae S288C	24-28
29226977-2	2018	Besides a chain of Ig domains, cardiac titin also contains a proline (P), glutamate (E), valine (V), lysine (K) (PEVK) domain and a cardiac-specific N2B domain, both are largely unstructured.	Proline	61-68	titin	Homo sapiens	39-44
29369808-6	2018	Epitope mapping revealed a serine- and proline-rich nonapeptide SPSPGSSLP comprising amino acids 606-614 of BICD2, shared with CENP-A but not CENP-B.	Proline	39-46	BICD cargo adaptor 2	Homo sapiens	108-113
29369808-6	2018	Epitope mapping revealed a serine- and proline-rich nonapeptide SPSPGSSLP comprising amino acids 606-614 of BICD2, shared with CENP-A but not CENP-B.	Proline	39-46	centromere protein A	Homo sapiens	127-133
29282276-7	2018	Delphilin is distinct from other formins in several ways: its expression is limited to Purkinje cells, it lacks classical autoinhibitory domains, and its FH1 domain has minimal proline-rich sequence.	Proline	177-184	Grid2 interacting protein	Homo sapiens	0-9
29024569-0	2018	Proline-Rich Chaperones Are Compared Computationally and Experimentally for Their Abilities to Facilitate Recombinant Butyrylcholinesterase Tetramerization in CHO Cells.	Proline	0-7	cholinesterase	Cricetulus griseus	118-139
29024569-2	2018	Efficient assembly of human BChE into tetramers requires an association with proline-rich peptide chaperones.	Proline	77-84	butyrylcholinesterase	Homo sapiens	28-32
29024569-3	2018	In this study, the incorporation of different proline-rich peptide chaperones into BChE is investigated computationally and experimentally.	Proline	46-53	cholinesterase	Cricetulus griseus	83-87
29024569-4	2018	First, the authors applied molecular dynamic (MD) simulations to interpret the interactions between proline-rich chaperones with human BChE tetramer domains.	Proline	100-107	cholinesterase	Cricetulus griseus	135-139
29024569-5	2018	The P24 chaperone which contains 24 prolines, promoted the association of BChE tetramer with a 74% simulated helicity of BChE subunits, whereas the control without chaperone and BChE with an 8-proline chaperone (P8) complex exhibited 55.8 and 60.6% predicted helicity, respectively.	Proline	36-44	cholinesterase	Cricetulus griseus	74-78
29024569-6	2018	The interaction of proline-rich chaperones with BChE subunits (B-P) provides a conduit to facilitate the interactions between BChE subunits (B-B) of the complex, which is mainly attributed to hydrophobic interactions and hydrogen-bond binding.	Proline	19-26	cholinesterase	Cricetulus griseus	48-52
29024569-6	2018	The interaction of proline-rich chaperones with BChE subunits (B-P) provides a conduit to facilitate the interactions between BChE subunits (B-B) of the complex, which is mainly attributed to hydrophobic interactions and hydrogen-bond binding.	Proline	19-26	cholinesterase	Cricetulus griseus	126-130
29024569-10	2018	Overall, our simulations provided a design concept for identifying proline-rich peptides that promote the rBChE tetramerization in CHO cells.	Proline	67-74	butyrylcholinesterase	Rattus norvegicus	106-111
29263160-9	2018	P4HB catalyses the hydroxylation of proline residues within the X-Pro-Gly repeats in the procollagen helical domain.	Proline	36-43	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-4
29289698-6	2018	TyrRS knockdown of PC12 cells with a small interfering RNA (siRNA) in the presence of 1.6 mM tyrosine, arginine, proline, or tryptophan significantly reduced the level of KTP, but not those of tyrosine-tyrosine, tyrosine-proline, or tyrosine-tryptophan.	Proline	113-120	tyrosyl-tRNA synthetase 1	Rattus norvegicus	0-5
29289698-6	2018	TyrRS knockdown of PC12 cells with a small interfering RNA (siRNA) in the presence of 1.6 mM tyrosine, arginine, proline, or tryptophan significantly reduced the level of KTP, but not those of tyrosine-tyrosine, tyrosine-proline, or tyrosine-tryptophan.	Proline	221-228	tyrosyl-tRNA synthetase 1	Rattus norvegicus	0-5
29043494-0	2018	Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2.	Proline	13-20	NK2 homeobox 1	Homo sapiens	96-100
29043494-5	2018	As proline was considered to be an effective alpha-helix breaker due to its restricted conformation, to better comprehend the effects of proline in the structure-activity relationship of NK-2, we constructed two NK-2 analogs.	Proline	3-10	NK2 homeobox 1	Homo sapiens	212-216
29043494-7	2018	Our results showed that introducing proline into the primary sequence of NK-2 significantly decreased the antitumor, antibacterial, and cytotoxic effects, as well as DNA binding activity by changing the alpha-helix content.	Proline	36-43	NK2 homeobox 1	Homo sapiens	73-77
29043494-9	2018	This study will allow for clearer insight into the role of proline in structure and bioactivity of NK-2 and provide a foundation for future studies.	Proline	59-66	NK2 homeobox 1	Homo sapiens	99-103
29255062-4	2018	Here, we show that a proline-to-threonine missense mutation (P474T) and a nonsense mutation (R502X) in the C-terminal RNA recognition motif (C-RRM) of the 65K protein impair the binding of 65K to U12 and U6atac snRNAs.	Proline	21-28	RNA, U6atac small nuclear	Homo sapiens	204-210
29487337-3	2018	A novel UPLC-MS method, measuring the conversion of ARG to ornithine (ORN), was developed to determine arginase 1 and arginase 2 inhibition by HOMOARG, lysine (LYS), proline (PRO), agmatine (AG), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and NG-Monomethyl-L-arginine (L-NMMA).	Proline	175-178	arginase 2	Homo sapiens	118-128
29335301-3	2018	Although CLK1 facilitates such trafficking through the phosphorylation of serine-proline dipeptides in the prototype SR protein SRSF1, an unrelated enzyme known as SR protein kinase 1 (SRPK1) performs the same function but does not efficiently modify these dipeptides in SRSF1.	Proline	81-88	CDC like kinase 1	Homo sapiens	9-13
29459744-6	2018	In the current study, we identified a sequence rich in proline, glutamic acid, serine, and threonine (PEST sequence) that enhanced the Ca2+-dependent degradation of HOXA10 by CAPN7.	Proline	55-62	homeobox A10	Homo sapiens	165-171
29459744-6	2018	In the current study, we identified a sequence rich in proline, glutamic acid, serine, and threonine (PEST sequence) that enhanced the Ca2+-dependent degradation of HOXA10 by CAPN7.	Proline	55-62	calpain 7	Homo sapiens	175-180
29352967-8	2018	This occurs by abstraction of the proR and proS hydrogens at C-11 and C-8, respectively, in agreement with different "head to tail" orientation in the active site.	Proline	43-47	RNA polymerase III subunit K	Homo sapiens	61-65
29352967-8	2018	This occurs by abstraction of the proR and proS hydrogens at C-11 and C-8, respectively, in agreement with different "head to tail" orientation in the active site.	Proline	43-47	homeobox C8	Homo sapiens	70-73
29535608-4	2018	In parallel, the expression of tetrameric form of proline-rich membrane anchor (PRiMA)-linked acetyl-cholinesterase (G4 AChE), a key enzyme to hydrolyze acetylcholine in cholinergic synapses, was induced in a dose-dependent manner: this induction included the associated protein PRiMA.	Proline	50-57	proline rich membrane anchor 1	Rattus norvegicus	80-85
29535608-4	2018	In parallel, the expression of tetrameric form of proline-rich membrane anchor (PRiMA)-linked acetyl-cholinesterase (G4 AChE), a key enzyme to hydrolyze acetylcholine in cholinergic synapses, was induced in a dose-dependent manner: this induction included the associated protein PRiMA.	Proline	50-57	acetylcholinesterase	Rattus norvegicus	120-124
29535608-4	2018	In parallel, the expression of tetrameric form of proline-rich membrane anchor (PRiMA)-linked acetyl-cholinesterase (G4 AChE), a key enzyme to hydrolyze acetylcholine in cholinergic synapses, was induced in a dose-dependent manner: this induction included the associated protein PRiMA.	Proline	50-57	proline rich membrane anchor 1	Rattus norvegicus	279-284
29432148-5	2018	Using these experiments, backbone resonance assignments were completed for the unstructured regulatory domain (residues 131-294) of the human transcription factor nuclear factor of activated T cells (NFATC2), which includes 28 proline residues located in functionally important serine-proline (SP) repeats.	Proline	227-234	nuclear factor of activated T cells 2	Homo sapiens	200-206
29335301-3	2018	Although CLK1 facilitates such trafficking through the phosphorylation of serine-proline dipeptides in the prototype SR protein SRSF1, an unrelated enzyme known as SR protein kinase 1 (SRPK1) performs the same function but does not efficiently modify these dipeptides in SRSF1.	Proline	81-88	RNA binding protein with serine rich domain 1	Homo sapiens	117-127
29335301-3	2018	Although CLK1 facilitates such trafficking through the phosphorylation of serine-proline dipeptides in the prototype SR protein SRSF1, an unrelated enzyme known as SR protein kinase 1 (SRPK1) performs the same function but does not efficiently modify these dipeptides in SRSF1.	Proline	81-88	serine and arginine rich splicing factor 1	Homo sapiens	128-133
29167286-2	2018	Whole-exome sequencing has revealed a cluster of pathogenic variants in PRRT2 (proline-rich transmembrane protein), a gene with a function in synaptic regulation that remains poorly understood.	Proline	79-86	proline rich transmembrane protein 2	Homo sapiens	72-77
29568391-1	2018	Proline degradation by proline dehydrogenase/proline oxidase (PRODH/POX) contributes to apoptosis or autophagy.	Proline	0-7	proline dehydrogenase 1	Homo sapiens	62-71
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	Proline	23-30	peptidase D	Homo sapiens	54-63
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	Proline	23-30	peptidase D	Homo sapiens	130-139
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	Proline	23-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	206-216
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	Proline	23-30	autophagy related 7	Homo sapiens	224-228
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	Proline	23-30	beclin 1	Homo sapiens	233-241
29410458-6	2018	We present NMR-spectral evidence that residues 1-40 constitute an intrinsically disordered region in CBS and interact with heme via a cysteine-proline based motif.	Proline	143-150	cystathionine beta-synthase	Homo sapiens	101-104
29456407-9	2018	CONCLUSION: In our CHB population, the NTCP-interacting domain was highly conserved, particularly the proline residues and essential amino acids related with the NTCP interaction, and the prevalence of rs2296651 was low/null.	Proline	102-109	solute carrier family 10 member 1	Homo sapiens	39-43
29515856-3	2018	Comparison of pro-R and pro-S proton abstraction in citrate synthase at the CCSD(T)-in-DFT//MM level yields the correct enantioselectivity.	Proline	14-17	citrate synthase	Homo sapiens	52-68
29440696-5	2018	Identification of the most abundant TRITC-modified protein in lymph nodes by tandem mass spectrometry revealed TRITC-modification of the N-terminal proline of macrophage migration inhibitory factor (MIF) - an evolutionary well-conserved protein involved in cell-mediated immunity and inflammation.	Proline	148-155	macrophage migration inhibitory factor	Homo sapiens	159-197
29440696-5	2018	Identification of the most abundant TRITC-modified protein in lymph nodes by tandem mass spectrometry revealed TRITC-modification of the N-terminal proline of macrophage migration inhibitory factor (MIF) - an evolutionary well-conserved protein involved in cell-mediated immunity and inflammation.	Proline	148-155	macrophage migration inhibitory factor	Homo sapiens	199-202
29440696-7	2018	Most haptens are electrophiles and can therefore modify the N-terminal proline of MIF, which has an unusually reactive amino group under physiological conditions; thus, modification of MIF by haptens may have an immunomodulating role in contact allergy as well as in other immunotoxicity reactions.	Proline	71-78	macrophage migration inhibitory factor	Homo sapiens	82-85
29440696-7	2018	Most haptens are electrophiles and can therefore modify the N-terminal proline of MIF, which has an unusually reactive amino group under physiological conditions; thus, modification of MIF by haptens may have an immunomodulating role in contact allergy as well as in other immunotoxicity reactions.	Proline	71-78	macrophage migration inhibitory factor	Homo sapiens	185-188
29426867-1	2018	Dipeptidyl peptidase IV (DPP IV, DPP4, or DAP IV) preferentially cleaves substrate peptides with Pro or Ala at the P1 position.	Proline	97-100	dipeptidyl peptidase 4	Homo sapiens	0-23
29426867-1	2018	Dipeptidyl peptidase IV (DPP IV, DPP4, or DAP IV) preferentially cleaves substrate peptides with Pro or Ala at the P1 position.	Proline	97-100	dipeptidyl peptidase 4	Homo sapiens	25-31
29426867-1	2018	Dipeptidyl peptidase IV (DPP IV, DPP4, or DAP IV) preferentially cleaves substrate peptides with Pro or Ala at the P1 position.	Proline	97-100	dipeptidyl peptidase 4	Homo sapiens	33-37
29292499-4	2018	MuSK interacts with and phosphorylates ROR1 at the cytoplasmic proline-rich domain.	Proline	63-70	muscle associated receptor tyrosine kinase	Homo sapiens	0-4
29292499-4	2018	MuSK interacts with and phosphorylates ROR1 at the cytoplasmic proline-rich domain.	Proline	63-70	receptor tyrosine kinase like orphan receptor 1	Homo sapiens	39-43
29370175-9	2018	Of these five nonsynonymous SNPs in Pou6f2, two resulted in changes in the amino acid proline which could result in altered secondary structure affecting protein function.	Proline	86-93	POU domain, class 6, transcription factor 2	Mus musculus	36-42
29479097-9	2018	CONCLUSIONS: In Pakistani women the association of TP53 gene codon 72 arginine/proline polymorphism was present..	Proline	79-86	tumor protein p53	Homo sapiens	51-55
29253181-0	2018	Control of proline accumulation under drought via a novel pathway comprising the histone methylase CAU1 and the transcription factor ANAC055.	Proline	11-18	SHK1 binding protein 1	Arabidopsis thaliana	99-103
29253181-0	2018	Control of proline accumulation under drought via a novel pathway comprising the histone methylase CAU1 and the transcription factor ANAC055.	Proline	11-18	NAC domain containing protein 3	Arabidopsis thaliana	133-140
29253181-3	2018	Here, we report that the histone methylase encoded by CAU1, which is genetically upstream of P5CS1 (encoding the proline biosynthetic enzyme Delta1-pyrroline-5-carboxylate synthetase 1), plays a crucial role in proline-mediated drought tolerance.	Proline	113-120	SHK1 binding protein 1	Arabidopsis thaliana	54-58
29253181-3	2018	Here, we report that the histone methylase encoded by CAU1, which is genetically upstream of P5CS1 (encoding the proline biosynthetic enzyme Delta1-pyrroline-5-carboxylate synthetase 1), plays a crucial role in proline-mediated drought tolerance.	Proline	113-120	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	93-98
29253181-3	2018	Here, we report that the histone methylase encoded by CAU1, which is genetically upstream of P5CS1 (encoding the proline biosynthetic enzyme Delta1-pyrroline-5-carboxylate synthetase 1), plays a crucial role in proline-mediated drought tolerance.	Proline	113-120	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	147-184
29253181-3	2018	Here, we report that the histone methylase encoded by CAU1, which is genetically upstream of P5CS1 (encoding the proline biosynthetic enzyme Delta1-pyrroline-5-carboxylate synthetase 1), plays a crucial role in proline-mediated drought tolerance.	Proline	211-218	SHK1 binding protein 1	Arabidopsis thaliana	54-58
29675245-1	2018	The ligation of sterically demanding peptidyl sites such as those involving Val-Val and Val-Pro linkages has proven to be extremely challenging with conventional NCL methods that rely on exogenous thiol additives.	Proline	92-95	nucleolin	Homo sapiens	162-165
29253181-3	2018	Here, we report that the histone methylase encoded by CAU1, which is genetically upstream of P5CS1 (encoding the proline biosynthetic enzyme Delta1-pyrroline-5-carboxylate synthetase 1), plays a crucial role in proline-mediated drought tolerance.	Proline	211-218	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	93-98
29253181-3	2018	Here, we report that the histone methylase encoded by CAU1, which is genetically upstream of P5CS1 (encoding the proline biosynthetic enzyme Delta1-pyrroline-5-carboxylate synthetase 1), plays a crucial role in proline-mediated drought tolerance.	Proline	211-218	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	147-184
29253181-6	2018	Thus, under drought stress, a decreased level of CAU1 led to an increased transcript level of ANAC055, which induced the expression of P5CS1 and increased proline level independently of CAS.	Proline	155-162	SHK1 binding protein 1	Arabidopsis thaliana	49-53
29253181-6	2018	Thus, under drought stress, a decreased level of CAU1 led to an increased transcript level of ANAC055, which induced the expression of P5CS1 and increased proline level independently of CAS.	Proline	155-162	NAC domain containing protein 3	Arabidopsis thaliana	94-101
29253181-7	2018	Drought tolerance and the level of proline were found to be decreased in the cau1 anac055 double-mutant, while proline supplementation restored drought sensitivity in the anac055 mutant.	Proline	35-42	SHK1 binding protein 1	Arabidopsis thaliana	77-81
29253181-7	2018	Drought tolerance and the level of proline were found to be decreased in the cau1 anac055 double-mutant, while proline supplementation restored drought sensitivity in the anac055 mutant.	Proline	35-42	NAC domain containing protein 3	Arabidopsis thaliana	82-89
29253181-7	2018	Drought tolerance and the level of proline were found to be decreased in the cau1 anac055 double-mutant, while proline supplementation restored drought sensitivity in the anac055 mutant.	Proline	111-118	NAC domain containing protein 3	Arabidopsis thaliana	171-178
29329072-6	2018	Selectivity towards NMUR1 was observed when the Phe residue in position 4 was modified, whereas higher potencies at NMUR2 were found when substitutions of the Pro residue in position 6 were executed.	Proline	159-162	neuromedin U receptor 2	Homo sapiens	116-121
29403379-4	2017	A single nucleotide polymorphism in Taar1 that encodes a missense proline to threonine mutation in the second transmembrane domain (Taar1m1J ) has been identified in the DBA/2J strain.	Proline	66-73	trace amine-associated receptor 1	Mus musculus	36-41
29111421-4	2018	The aim of this study is to computationally predict the potential impact of different single amino acid substitutions at position 75 of Cx32, from arginine (R) to proline (P), glutamine (Q) and tryptophan (W).	Proline	163-170	gap junction protein beta 1	Homo sapiens	136-140
30030836-7	2018	Notch activation can be enhanced by mutations that delete the C-terminal proline (P), glutamic acid (E), serine (S), and threonine (T) (PEST) domain.	Proline	73-80	notch receptor 1	Homo sapiens	0-5
29084919-7	2018	Moreover, we demonstrated that hypoxia activated proline biosynthesis via upregulation of ALDH18A1, subsequently leading to accumulation of hydroxyproline via attenuated PRODH2 activity.	Proline	49-56	aldehyde dehydrogenase 18 family member A1	Homo sapiens	90-98
29084919-7	2018	Moreover, we demonstrated that hypoxia activated proline biosynthesis via upregulation of ALDH18A1, subsequently leading to accumulation of hydroxyproline via attenuated PRODH2 activity.	Proline	49-56	proline dehydrogenase 2	Homo sapiens	170-176
29084919-9	2018	Finally, inhibition of proline biosynthesis significantly enhanced cytotoxicity of sorafenib in vitro and in vivoConclusions: Our results demonstrate that hypoxic microenvironment activates proline metabolism, resulting in accumulation of hydroxyproline that promotes HCC tumor progression and sorafenib resistance through modulating HIF1alpha.	Proline	23-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	334-343
29084919-9	2018	Finally, inhibition of proline biosynthesis significantly enhanced cytotoxicity of sorafenib in vitro and in vivoConclusions: Our results demonstrate that hypoxic microenvironment activates proline metabolism, resulting in accumulation of hydroxyproline that promotes HCC tumor progression and sorafenib resistance through modulating HIF1alpha.	Proline	190-197	hypoxia inducible factor 1 subunit alpha	Homo sapiens	334-343
29301548-1	2018	BACKGROUND: Cyclin-dependent kinase 5 (Cdk5) belongs to the family of proline-directed serine/threonine kinases and plays a critical role in neuronal differentiation, migration, synaptogenesis, plasticity, neurotransmission and apoptosis.	Proline	70-77	cyclin-dependent kinase 5	Mus musculus	12-37
29301548-1	2018	BACKGROUND: Cyclin-dependent kinase 5 (Cdk5) belongs to the family of proline-directed serine/threonine kinases and plays a critical role in neuronal differentiation, migration, synaptogenesis, plasticity, neurotransmission and apoptosis.	Proline	70-77	cyclin-dependent kinase 5	Mus musculus	39-43
29132690-1	2018	Cyclin-dependent kinase 5 (CDK5) is a proline-directed serine/threonine kinase that has been shown to play important roles in many tissues except the nervous system.	Proline	38-45	cyclin-dependent kinase 5	Mus musculus	0-25
29132690-1	2018	Cyclin-dependent kinase 5 (CDK5) is a proline-directed serine/threonine kinase that has been shown to play important roles in many tissues except the nervous system.	Proline	38-45	cyclin-dependent kinase 5	Mus musculus	27-31
29311663-0	2018	A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans.	Proline	2-9	interferon alpha and beta receptor subunit 1	Homo sapiens	22-28
29311663-4	2018	Receptor mutagenesis and cell signaling studies establish that the IFNAR1 mutation corresponding to a proline deletion in the hinge region of the membrane-proximal domain of IFNAR1 decreases the binding affinity of IFNAR1 to IFN-beta, impeding type I IFN signaling.	Proline	102-109	interferon alpha and beta receptor subunit 1	Homo sapiens	67-73
29311663-4	2018	Receptor mutagenesis and cell signaling studies establish that the IFNAR1 mutation corresponding to a proline deletion in the hinge region of the membrane-proximal domain of IFNAR1 decreases the binding affinity of IFNAR1 to IFN-beta, impeding type I IFN signaling.	Proline	102-109	interferon alpha and beta receptor subunit 1	Homo sapiens	174-180
29311663-4	2018	Receptor mutagenesis and cell signaling studies establish that the IFNAR1 mutation corresponding to a proline deletion in the hinge region of the membrane-proximal domain of IFNAR1 decreases the binding affinity of IFNAR1 to IFN-beta, impeding type I IFN signaling.	Proline	102-109	interferon alpha and beta receptor subunit 1	Homo sapiens	174-180
29311663-4	2018	Receptor mutagenesis and cell signaling studies establish that the IFNAR1 mutation corresponding to a proline deletion in the hinge region of the membrane-proximal domain of IFNAR1 decreases the binding affinity of IFNAR1 to IFN-beta, impeding type I IFN signaling.	Proline	102-109	interferon beta 1	Homo sapiens	225-233
29175388-3	2018	In the present study, we show that overexpression of the functional FRIGIDA gene in wild-type Col background (ColFRI) positively enhances the drought tolerance by activating P5CS1 expression and promoting proline accumulation during water stress.	Proline	205-212	FRIGIDA-like protein	Arabidopsis thaliana	68-75
28821999-6	2018	Decreased receptor of advanced glycation end products (RAGE) immunocontent supports the assumption that downregulated RAGE/Erk1/2 pathway could be involved in hypophosphorylated lysine/serine/proline (KSP) repeats on neurofilament subunits and disturbed axonal transport.	Proline	192-199	advanced glycosylation end product-specific receptor	Rattus norvegicus	10-53
28821999-6	2018	Decreased receptor of advanced glycation end products (RAGE) immunocontent supports the assumption that downregulated RAGE/Erk1/2 pathway could be involved in hypophosphorylated lysine/serine/proline (KSP) repeats on neurofilament subunits and disturbed axonal transport.	Proline	192-199	advanced glycosylation end product-specific receptor	Rattus norvegicus	55-59
28821999-6	2018	Decreased receptor of advanced glycation end products (RAGE) immunocontent supports the assumption that downregulated RAGE/Erk1/2 pathway could be involved in hypophosphorylated lysine/serine/proline (KSP) repeats on neurofilament subunits and disturbed axonal transport.	Proline	192-199	advanced glycosylation end product-specific receptor	Rattus norvegicus	118-122
28821999-6	2018	Decreased receptor of advanced glycation end products (RAGE) immunocontent supports the assumption that downregulated RAGE/Erk1/2 pathway could be involved in hypophosphorylated lysine/serine/proline (KSP) repeats on neurofilament subunits and disturbed axonal transport.	Proline	192-199	mitogen activated protein kinase 3	Rattus norvegicus	123-129
29158086-3	2018	The interaction involves the N-terminal proline-rich motif (PRM) of RARalpha and the SH3-like domain of PFN2a.	Proline	40-47	retinoic acid receptor, alpha	Mus musculus	68-76
28877958-0	2018	Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression.	Proline	0-7	transient receptor potential cation channel subfamily C member 6	Homo sapiens	61-66
29169183-0	2018	MYC regulation of glutamine-proline regulatory axis is key in luminal B breast cancer.	Proline	28-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-3
29169183-7	2018	High protein expression of the glutamine-proline enzymes were all associated with high MYC protein in Luminal B tumours only (P&lt;0.001).	Proline	41-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	87-90
30381661-7	2018	The inhibitory activity of these bivalent ligands against EGFR autophosphorylation was measured and was found to increase as the linker enlarges up to a 15-mer proline linker.	Proline	160-167	epidermal growth factor receptor	Homo sapiens	58-62
28877958-8	2018	We confirmed serine 14 as a target of MAPKs and proline-directed kinases like cyclin-dependent kinase 5 (Cdk5) in cell-based as well as in vitro kinase assays and quantitative phosphoproteomic analysis of TRPC6.	Proline	48-55	cyclin dependent kinase 5	Homo sapiens	78-103
29307398-6	2018	TP53 codon 72 (arginine) exhibits higher rates of apoptosis and leukemia inhibitory factor expression, whereas the C allele (proline) reduces leukemia inhibitory factor expression.	Proline	125-132	LIF interleukin 6 family cytokine	Homo sapiens	142-168
28877958-8	2018	We confirmed serine 14 as a target of MAPKs and proline-directed kinases like cyclin-dependent kinase 5 (Cdk5) in cell-based as well as in vitro kinase assays and quantitative phosphoproteomic analysis of TRPC6.	Proline	48-55	cyclin dependent kinase 5	Homo sapiens	105-109
29074133-3	2018	Sequence analysis revealed the typical characteristics of On-CD28 protein; for instance, the proline-based motif (117TYPPPL122) is essential in binding of CD28 to CD80/86 ligands.	Proline	93-100	T-lymphocyte activation antigen CD86	Oreochromis niloticus	163-170
28877958-8	2018	We confirmed serine 14 as a target of MAPKs and proline-directed kinases like cyclin-dependent kinase 5 (Cdk5) in cell-based as well as in vitro kinase assays and quantitative phosphoproteomic analysis of TRPC6.	Proline	48-55	transient receptor potential cation channel subfamily C member 6	Homo sapiens	205-210
29773422-3	2018	We present an unusual case of a healthy man with severely decreased HDL-C because of a novel homozygous variant causing a Proline > Arginine amino acid change at position 1412 in the ATP-binding cassette transporter A1 gene.	Proline	122-129	ATP binding cassette subfamily A member 1	Homo sapiens	183-218
29138803-0	2018	Toll like receptors TLR1/2, TLR6 and MUC5B as binding interaction partners with cytostatic proline rich polypeptide 1 in human chondrosarcoma.	Proline	91-98	toll like receptor 1	Homo sapiens	20-26
29138803-0	2018	Toll like receptors TLR1/2, TLR6 and MUC5B as binding interaction partners with cytostatic proline rich polypeptide 1 in human chondrosarcoma.	Proline	91-98	toll like receptor 6	Homo sapiens	28-32
29138803-0	2018	Toll like receptors TLR1/2, TLR6 and MUC5B as binding interaction partners with cytostatic proline rich polypeptide 1 in human chondrosarcoma.	Proline	91-98	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	37-42
29138803-2	2018	We have previously reported that mTORC1 inhibitor, antitumorigenic cytostatic proline rich polypeptide 1 (PRP-1), galarmin caused a significant upregulation of tumor suppressors including TET1/2 and SOCS3 (known to be involved in inflammatory processes), downregulation of oncoproteins and embryonic stem cell marker miR-302C and its targets Nanog, c-Myc and Bmi-1 in human chondrosarcoma.	Proline	78-85	CREB regulated transcription coactivator 1	Mus musculus	33-39
29138803-2	2018	We have previously reported that mTORC1 inhibitor, antitumorigenic cytostatic proline rich polypeptide 1 (PRP-1), galarmin caused a significant upregulation of tumor suppressors including TET1/2 and SOCS3 (known to be involved in inflammatory processes), downregulation of oncoproteins and embryonic stem cell marker miR-302C and its targets Nanog, c-Myc and Bmi-1 in human chondrosarcoma.	Proline	78-85	tet methylcytosine dioxygenase 1	Homo sapiens	188-194
29138803-2	2018	We have previously reported that mTORC1 inhibitor, antitumorigenic cytostatic proline rich polypeptide 1 (PRP-1), galarmin caused a significant upregulation of tumor suppressors including TET1/2 and SOCS3 (known to be involved in inflammatory processes), downregulation of oncoproteins and embryonic stem cell marker miR-302C and its targets Nanog, c-Myc and Bmi-1 in human chondrosarcoma.	Proline	78-85	suppressor of cytokine signaling 3	Homo sapiens	199-204
29138803-2	2018	We have previously reported that mTORC1 inhibitor, antitumorigenic cytostatic proline rich polypeptide 1 (PRP-1), galarmin caused a significant upregulation of tumor suppressors including TET1/2 and SOCS3 (known to be involved in inflammatory processes), downregulation of oncoproteins and embryonic stem cell marker miR-302C and its targets Nanog, c-Myc and Bmi-1 in human chondrosarcoma.	Proline	78-85	microRNA 302c	Homo sapiens	317-325
29138803-2	2018	We have previously reported that mTORC1 inhibitor, antitumorigenic cytostatic proline rich polypeptide 1 (PRP-1), galarmin caused a significant upregulation of tumor suppressors including TET1/2 and SOCS3 (known to be involved in inflammatory processes), downregulation of oncoproteins and embryonic stem cell marker miR-302C and its targets Nanog, c-Myc and Bmi-1 in human chondrosarcoma.	Proline	78-85	Nanog homeobox	Homo sapiens	342-347
29138803-2	2018	We have previously reported that mTORC1 inhibitor, antitumorigenic cytostatic proline rich polypeptide 1 (PRP-1), galarmin caused a significant upregulation of tumor suppressors including TET1/2 and SOCS3 (known to be involved in inflammatory processes), downregulation of oncoproteins and embryonic stem cell marker miR-302C and its targets Nanog, c-Myc and Bmi-1 in human chondrosarcoma.	Proline	78-85	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	349-354
29138803-2	2018	We have previously reported that mTORC1 inhibitor, antitumorigenic cytostatic proline rich polypeptide 1 (PRP-1), galarmin caused a significant upregulation of tumor suppressors including TET1/2 and SOCS3 (known to be involved in inflammatory processes), downregulation of oncoproteins and embryonic stem cell marker miR-302C and its targets Nanog, c-Myc and Bmi-1 in human chondrosarcoma.	Proline	78-85	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	359-364
30149861-2	2018	In humans, peptidyl-prolyl isomerase cis-trans isomerase NIMA interacting 1 (Pin1) is responsible for mediating fast conversion between cis- and trans-conformations of serine/threonine-proline (S/T-P) motifs in a large number of cellular pathways, many of which are involved in normal development as well as progression of several cancers and diseases.	Proline	185-192	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	11-75
29117459-3	2018	Proline plays an important role in P2Y12R ligand binding and signaling defects.	Proline	0-7	purinergic receptor P2Y12	Homo sapiens	35-41
30149861-2	2018	In humans, peptidyl-prolyl isomerase cis-trans isomerase NIMA interacting 1 (Pin1) is responsible for mediating fast conversion between cis- and trans-conformations of serine/threonine-proline (S/T-P) motifs in a large number of cellular pathways, many of which are involved in normal development as well as progression of several cancers and diseases.	Proline	185-192	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	77-81
29111393-1	2018	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
29111393-1	2018	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
28371297-9	2018	Correlation between PRG4 and proline-rich acidic protein 1 variation and Matsuda insulin sensitivity increment was showed.	Proline	29-36	proteoglycan 4	Homo sapiens	20-24
29403556-2	2018	Proline metabolism is of critical importance for tumor cells, and pyrroline-5-carboxylate reductase 1 (PYCR1), a key proline biosynthesis enzyme, has been reported to be overexpressed in prostate cancer and to promote tumor cell growth in breast cancer.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	103-108
29403556-2	2018	Proline metabolism is of critical importance for tumor cells, and pyrroline-5-carboxylate reductase 1 (PYCR1), a key proline biosynthesis enzyme, has been reported to be overexpressed in prostate cancer and to promote tumor cell growth in breast cancer.	Proline	117-124	pyrroline-5-carboxylate reductase 1	Homo sapiens	66-101
29403556-2	2018	Proline metabolism is of critical importance for tumor cells, and pyrroline-5-carboxylate reductase 1 (PYCR1), a key proline biosynthesis enzyme, has been reported to be overexpressed in prostate cancer and to promote tumor cell growth in breast cancer.	Proline	117-124	pyrroline-5-carboxylate reductase 1	Homo sapiens	103-108
29210629-14	2018	Notably, the Dep-3 peptide contained a Thr-Pro-Met-Ser sequence, which is similar to the Ser2-Pro3-Thr4-Ser5 (Ser/Thr-Pro-partially hydrophobic residue-Ser) sequence found in CTD, which is an endogenous substrate for Scp1.	Proline	43-46	jagged canonical Notch ligand 2	Homo sapiens	89-93
29569995-6	2018	Phosphorylation targets multiple serine-proline (SP) or threonine-proline (TP) residues within the PABP1 linker region.	Proline	40-47	poly(A) binding protein cytoplasmic 1	Homo sapiens	99-104
29210629-14	2018	Notably, the Dep-3 peptide contained a Thr-Pro-Met-Ser sequence, which is similar to the Ser2-Pro3-Thr4-Ser5 (Ser/Thr-Pro-partially hydrophobic residue-Ser) sequence found in CTD, which is an endogenous substrate for Scp1.	Proline	94-97	jagged canonical Notch ligand 2	Homo sapiens	89-93
29210629-16	2018	BP-14 peptide contained Ser- Thr-Tyr and Pro-Phe-Glu sequences, which are similar to the Ser-Thr-Trp and Ile-Phe-Glu sequences found in M12-6a, suggesting that one or both of these tripeptides may be the binding motif(s) recognized by Scp1.	Proline	41-44	BP14	Homo sapiens	0-5
29118189-1	2017	PIN1 is a peptidyl-prolyl isomerase that catalyzes the cis/trans isomerization of peptide bonds between proline and phosphorylated serine/threonine residues.	Proline	104-111	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
29312416-0	2017	Arabidopsis AMINO ACID PERMEASE1 Contributes to Salt Stress-Induced Proline Uptake from Exogenous Sources.	Proline	68-75	amino acid permease 1	Arabidopsis thaliana	12-32
29321966-13	2018	Moreover, AMP-activated protein kinase alpha, proline-rich AKT substrate of 40 kDa, AKT, and extracellular signal-regulated kinase phosphorylation levels were down-regulated in GPR137 knockdown cells.	Proline	46-53	AKT serine/threonine kinase 1	Homo sapiens	59-62
29321966-13	2018	Moreover, AMP-activated protein kinase alpha, proline-rich AKT substrate of 40 kDa, AKT, and extracellular signal-regulated kinase phosphorylation levels were down-regulated in GPR137 knockdown cells.	Proline	46-53	G protein-coupled receptor 137	Homo sapiens	177-183
29312416-3	2017	We isolated the proline resistant 1-1 (pre1-1) mutant and map-based cloning identified PRE1 as AMINO ACID PERMEASE1 (AAP1, At1g58360), which encodes a plasma membrane-localized amino acid permease.	Proline	16-23	basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	39-45
29312416-3	2017	We isolated the proline resistant 1-1 (pre1-1) mutant and map-based cloning identified PRE1 as AMINO ACID PERMEASE1 (AAP1, At1g58360), which encodes a plasma membrane-localized amino acid permease.	Proline	16-23	basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	87-91
29312416-3	2017	We isolated the proline resistant 1-1 (pre1-1) mutant and map-based cloning identified PRE1 as AMINO ACID PERMEASE1 (AAP1, At1g58360), which encodes a plasma membrane-localized amino acid permease.	Proline	16-23	amino acid permease 1	Arabidopsis thaliana	95-115
29312416-3	2017	We isolated the proline resistant 1-1 (pre1-1) mutant and map-based cloning identified PRE1 as AMINO ACID PERMEASE1 (AAP1, At1g58360), which encodes a plasma membrane-localized amino acid permease.	Proline	16-23	amino acid permease 1	Arabidopsis thaliana	117-121
29312416-6	2017	When grown on proline-containing medium, pre1-1 mutants accumulated significantly less proline than did the wild type.	Proline	14-21	basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	41-47
29312416-6	2017	When grown on proline-containing medium, pre1-1 mutants accumulated significantly less proline than did the wild type.	Proline	87-94	basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	41-47
29308014-2	2017	Using different mouse models, we demonstrate the role of inflammation-generated extracellular matrix fragments ac-PGP (N-acetyl-proline-glycine-proline) on tumor cells dissemination to lung parenchyma.	Proline	128-135	phosphoglycolate phosphatase	Mus musculus	114-117
29312416-7	2017	Under salt stress, proline uptake decreased significantly in pre1-1 mutants.	Proline	19-26	basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	61-67
29312416-9	2017	These results suggest that AAP1 functions in the increase of proline uptake during salt stress.	Proline	61-68	amino acid permease 1	Arabidopsis thaliana	27-31
29312416-11	2017	We conclude that plants can increase proline accumulation by AtAAP1-mediated proline uptake from exogenous source, which help to improve the salt tolerance of seedlings.	Proline	37-44	amino acid permease 1	Arabidopsis thaliana	61-67
29312416-11	2017	We conclude that plants can increase proline accumulation by AtAAP1-mediated proline uptake from exogenous source, which help to improve the salt tolerance of seedlings.	Proline	77-84	amino acid permease 1	Arabidopsis thaliana	61-67
29097029-4	2017	In both the crystal and solution states, the conformations of [Pro]ASC, [Aze]ASC and [DeltaPro]ASC were novel square structures having two trans imide bonds and stabilized by two intramolecular hydrogen bonds.	Proline	63-66	PYD and CARD domain containing	Homo sapiens	67-70
29066352-0	2017	Loss of Ribosomal Protein L24A (RPL24A) suppresses proline accumulation of Arabidopsis thaliana ring zinc finger 1 (atrzf1) mutant in response to osmotic stress.	Proline	51-58	ribosomal protein L24	Arabidopsis thaliana	8-12
29066352-0	2017	Loss of Ribosomal Protein L24A (RPL24A) suppresses proline accumulation of Arabidopsis thaliana ring zinc finger 1 (atrzf1) mutant in response to osmotic stress.	Proline	51-58	ribosomal protein L24	Arabidopsis thaliana	32-38
29066352-0	2017	Loss of Ribosomal Protein L24A (RPL24A) suppresses proline accumulation of Arabidopsis thaliana ring zinc finger 1 (atrzf1) mutant in response to osmotic stress.	Proline	51-58	RING/U-box superfamily protein	Arabidopsis thaliana	75-114
29066352-0	2017	Loss of Ribosomal Protein L24A (RPL24A) suppresses proline accumulation of Arabidopsis thaliana ring zinc finger 1 (atrzf1) mutant in response to osmotic stress.	Proline	51-58	RING/U-box superfamily protein	Arabidopsis thaliana	116-122
29066352-4	2017	Using atrzf1 as a parental plant for T-DNA tagging mutagenesis, we identified a suppressor mutant, termed proline content alterative 21 (pca21), that displayed reduced Pro contents compared with the atrzf1 under osmotic stress conditions.	Proline	106-113	RING/U-box superfamily protein	Arabidopsis thaliana	6-12
29097029-4	2017	In both the crystal and solution states, the conformations of [Pro]ASC, [Aze]ASC and [DeltaPro]ASC were novel square structures having two trans imide bonds and stabilized by two intramolecular hydrogen bonds.	Proline	63-66	PYD and CARD domain containing	Homo sapiens	77-80
29097029-4	2017	In both the crystal and solution states, the conformations of [Pro]ASC, [Aze]ASC and [DeltaPro]ASC were novel square structures having two trans imide bonds and stabilized by two intramolecular hydrogen bonds.	Proline	63-66	PYD and CARD domain containing	Homo sapiens	77-80
29097029-8	2017	[Pro]ASC and [Pip]ASC showed strong cytotoxicity, but [Aze]ASC and [DeltaPro]ASC showed no cytotoxicity.	Proline	1-4	PYD and CARD domain containing	Homo sapiens	5-8
29242833-0	2017	Put3 Positively Regulates Proline Utilization in Candida albicans.	Proline	26-33	Put3p	Saccharomyces cerevisiae S288C	0-4
29242833-1	2017	The zinc cluster transcription factor Put3 was initially characterized in Saccharomyces cerevisiae as the transcriptional activator of PUT1 and PUT2, two genes acting early in the proline assimilation pathway.	Proline	180-187	Put3p	Saccharomyces cerevisiae S288C	38-42
29242833-1	2017	The zinc cluster transcription factor Put3 was initially characterized in Saccharomyces cerevisiae as the transcriptional activator of PUT1 and PUT2, two genes acting early in the proline assimilation pathway.	Proline	180-187	proline dehydrogenase	Saccharomyces cerevisiae S288C	135-139
29321759-0	2017	Deficits in the Proline-Rich Synapse-Associated Shank3 Protein in Multiple Neuropsychiatric Disorders.	Proline	16-23	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	48-54
29242833-1	2017	The zinc cluster transcription factor Put3 was initially characterized in Saccharomyces cerevisiae as the transcriptional activator of PUT1 and PUT2, two genes acting early in the proline assimilation pathway.	Proline	180-187	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	144-148
29242833-3	2017	However, a C. albicans put3 null mutant cannot grow on proline, suggesting that as in S. cerevisiae, C. albicans Put3 (CaPut3) is required for proline catabolism, and because the C. albicans put3 null mutant grew efficiently on glutamate as the sole carbon or nitrogen source, it appears that CaPut3 also regulates the early genes of the pathway.	Proline	55-62	Put3p	Saccharomyces cerevisiae S288C	113-117
29242833-3	2017	However, a C. albicans put3 null mutant cannot grow on proline, suggesting that as in S. cerevisiae, C. albicans Put3 (CaPut3) is required for proline catabolism, and because the C. albicans put3 null mutant grew efficiently on glutamate as the sole carbon or nitrogen source, it appears that CaPut3 also regulates the early genes of the pathway.	Proline	143-150	Put3p	Saccharomyces cerevisiae S288C	23-27
29242833-3	2017	However, a C. albicans put3 null mutant cannot grow on proline, suggesting that as in S. cerevisiae, C. albicans Put3 (CaPut3) is required for proline catabolism, and because the C. albicans put3 null mutant grew efficiently on glutamate as the sole carbon or nitrogen source, it appears that CaPut3 also regulates the early genes of the pathway.	Proline	143-150	Put3p	Saccharomyces cerevisiae S288C	113-117
29242833-3	2017	However, a C. albicans put3 null mutant cannot grow on proline, suggesting that as in S. cerevisiae, C. albicans Put3 (CaPut3) is required for proline catabolism, and because the C. albicans put3 null mutant grew efficiently on glutamate as the sole carbon or nitrogen source, it appears that CaPut3 also regulates the early genes of the pathway.	Proline	143-150	Put3p	Saccharomyces cerevisiae S288C	191-195
29242833-4	2017	CaPut3 showed direct binding to the CaPUT1 promoter, and both PUT1 and PUT2 were upregulated in response to proline addition in a Put3-dependent manner, as well as in a C. albicans strain expressing a hyperactive Put3.	Proline	108-115	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	71-75
29242833-4	2017	CaPut3 showed direct binding to the CaPUT1 promoter, and both PUT1 and PUT2 were upregulated in response to proline addition in a Put3-dependent manner, as well as in a C. albicans strain expressing a hyperactive Put3.	Proline	108-115	Put3p	Saccharomyces cerevisiae S288C	2-6
29242833-4	2017	CaPut3 showed direct binding to the CaPUT1 promoter, and both PUT1 and PUT2 were upregulated in response to proline addition in a Put3-dependent manner, as well as in a C. albicans strain expressing a hyperactive Put3.	Proline	108-115	Put3p	Saccharomyces cerevisiae S288C	130-134
29242833-5	2017	CaPut3 directs proline degradation even in the presence of a good nitrogen source such as ammonia, which contrasts with S. cerevisiae Put3 (ScPut3)-regulated proline catabolism, which only occurs in the absence of a rich nitrogen source.	Proline	15-22	Put3p	Saccharomyces cerevisiae S288C	2-6
29242833-10	2017	We show that the Put3 transcription factor allows the pathogen to completely degrade proline to usable nitrogen and carbon by evading regulatory restrictions imposed on its S. cerevisiae ortholog, which mandates conditional use of proline only as a nitrogen source in the baker"s yeast.	Proline	85-92	Put3p	Saccharomyces cerevisiae S288C	17-21
29242833-10	2017	We show that the Put3 transcription factor allows the pathogen to completely degrade proline to usable nitrogen and carbon by evading regulatory restrictions imposed on its S. cerevisiae ortholog, which mandates conditional use of proline only as a nitrogen source in the baker"s yeast.	Proline	231-238	Put3p	Saccharomyces cerevisiae S288C	17-21
29233996-4	2017	PEPD binds to the proline-rich domain in p53, which inhibits phosphorylation of nuclear p53 and MDM2-mediated mitochondrial translocation of nuclear and cytoplasmic p53.	Proline	18-25	peptidase D	Homo sapiens	0-4
29233996-4	2017	PEPD binds to the proline-rich domain in p53, which inhibits phosphorylation of nuclear p53 and MDM2-mediated mitochondrial translocation of nuclear and cytoplasmic p53.	Proline	18-25	tumor protein p53	Homo sapiens	41-44
29233996-4	2017	PEPD binds to the proline-rich domain in p53, which inhibits phosphorylation of nuclear p53 and MDM2-mediated mitochondrial translocation of nuclear and cytoplasmic p53.	Proline	18-25	tumor protein p53	Homo sapiens	88-91
29233996-4	2017	PEPD binds to the proline-rich domain in p53, which inhibits phosphorylation of nuclear p53 and MDM2-mediated mitochondrial translocation of nuclear and cytoplasmic p53.	Proline	18-25	MDM2 proto-oncogene	Homo sapiens	96-100
29233996-4	2017	PEPD binds to the proline-rich domain in p53, which inhibits phosphorylation of nuclear p53 and MDM2-mediated mitochondrial translocation of nuclear and cytoplasmic p53.	Proline	18-25	tumor protein p53	Homo sapiens	88-91
29321759-2	2017	One recently characterized core postsynaptic element essential to the efficient operation of this complex network is a relatively abundant ~184.7 kDa proline-rich synapse-associated cytoskeletal protein known as Shank3 (SH3-ankyrin repeat domain; encoded at human chr 22q13.33).	Proline	150-157	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	212-218
29222481-6	2017	Furthermore, HIF-P4H-1 inactivation increases p53 activity and stability and hydroxylation of proline 142 in p53 has an important role in this regulation.	Proline	94-101	tumor protein p53	Homo sapiens	109-112
28972163-7	2017	Although degradation of mouse stearoyl-CoA desaturase 1 (SCD1) was unaffected by changes in fatty acid unsaturation, introduction of the N-terminal sequential proline residues into SCD1 conferred responsiveness to unsaturated fatty acid-dependent degradation.	Proline	159-166	stearoyl-Coenzyme A desaturase 1	Mus musculus	181-185
28972163-8	2017	Furthermore, we also found that the Ca2+-dependent cysteine protease calpain is involved in the sequential proline-dependent degradation of DESAT1.	Proline	107-114	Calpain-A	Drosophila melanogaster	69-76
28972163-8	2017	Furthermore, we also found that the Ca2+-dependent cysteine protease calpain is involved in the sequential proline-dependent degradation of DESAT1.	Proline	107-114	Desaturase 1	Drosophila melanogaster	140-146
28987732-5	2017	Proline substitutions on the PC1-proximal side completely abolished transport and reduced backbone flexibility of the switch loop, which adopted a conformation restricting the pathway toward the deep binding pocket.	Proline	0-7	polycystin 1, transient receptor potential channel interacting	Homo sapiens	29-32
28939767-2	2017	Reuptake is regulated by kinase pathways and drug exposure, allowing for fine-tuning of clearance in response to specific conditions, and here we examine the impact of transporter ligands on DAT residue Thr-53, a proline-directed phosphorylation site previously implicated in AMPH-stimulated efflux mechanisms.	Proline	213-220	solute carrier family 6 member 3	Rattus norvegicus	191-194
29255427-8	2017	Intriguingly, the highest change was found for FKBP11, a protein belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides.	Proline	163-170	FKBP prolyl isomerase 11	Homo sapiens	47-53
29126016-6	2017	Importantly, the functions of the kon and pros homologues NG2 and prox1, respectively, are conserved in mammalian NG2 glia.	Proline	42-46	chondroitin sulfate proteoglycan 4	Homo sapiens	58-61
29126016-6	2017	Importantly, the functions of the kon and pros homologues NG2 and prox1, respectively, are conserved in mammalian NG2 glia.	Proline	42-46	prospero homeobox 1	Homo sapiens	66-71
29126016-6	2017	Importantly, the functions of the kon and pros homologues NG2 and prox1, respectively, are conserved in mammalian NG2 glia.	Proline	42-46	chondroitin sulfate proteoglycan 4	Homo sapiens	114-117
28858431-1	2017	HLA-B*67:01:03 has one synonymous nucleotide change from HLA-B*67:01:02 at nucleotide 873 (codon 267 Proline).	Proline	101-108	major histocompatibility complex, class I, B	Homo sapiens	0-5
28858431-1	2017	HLA-B*67:01:03 has one synonymous nucleotide change from HLA-B*67:01:02 at nucleotide 873 (codon 267 Proline).	Proline	101-108	major histocompatibility complex, class I, B	Homo sapiens	57-62
28465529-5	2017	Moreover, the cytoplamic, and more specifically the proline-rich domain (PRD), of ROR1 was required for it to associate with HS1 and allow for F-actin polymerization in response to Wnt5a.	Proline	52-59	receptor tyrosine kinase like orphan receptor 1	Homo sapiens	82-86
28465529-5	2017	Moreover, the cytoplamic, and more specifically the proline-rich domain (PRD), of ROR1 was required for it to associate with HS1 and allow for F-actin polymerization in response to Wnt5a.	Proline	52-59	hematopoietic cell-specific Lyn substrate 1	Homo sapiens	125-128
28465529-5	2017	Moreover, the cytoplamic, and more specifically the proline-rich domain (PRD), of ROR1 was required for it to associate with HS1 and allow for F-actin polymerization in response to Wnt5a.	Proline	52-59	Wnt family member 5A	Homo sapiens	181-186
28465529-6	2017	Accordingly, we introduced single amino acid substitutions of proline (P) to alanine (A) in the ROR1 PRD at positions 784, 808, 826, 841 or 850 in potential SH3-binding motifs.	Proline	62-69	receptor tyrosine kinase like orphan receptor 1	Homo sapiens	96-100
29208911-3	2017	Using X-ray crystallography, proline isomerisation has been shown to occur following formation of an antigen-antibody complex between the target epiregulin (EPR) and the antibody 9E5, at proline (Pro103), located in the third complementarity-determining region (CDR) of the heavy chain of 9E5.	Proline	29-36	epiregulin	Homo sapiens	145-155
29208911-3	2017	Using X-ray crystallography, proline isomerisation has been shown to occur following formation of an antigen-antibody complex between the target epiregulin (EPR) and the antibody 9E5, at proline (Pro103), located in the third complementarity-determining region (CDR) of the heavy chain of 9E5.	Proline	187-194	epiregulin	Homo sapiens	145-155
28510193-2	2017	In plants, P5CS proteins are key enzymes that catalyzed the rate-limiting steps of proline synthesis, and proline is a well-known osmoprotectant that is closely related to abiotic stress tolerance.	Proline	83-90	aldehyde dehydrogenase 18 family member A1	Homo sapiens	11-15
28510193-2	2017	In plants, P5CS proteins are key enzymes that catalyzed the rate-limiting steps of proline synthesis, and proline is a well-known osmoprotectant that is closely related to abiotic stress tolerance.	Proline	106-113	aldehyde dehydrogenase 18 family member A1	Homo sapiens	11-15
28510193-9	2017	However, there should be other P5CS homologues in the lily genome, and some of them could be highly stress-induced and more important for proline accumulation.	Proline	138-145	aldehyde dehydrogenase 18 family member A1	Homo sapiens	31-35
28510193-10	2017	Future studies on P5CS family genes would be of great importance to proline-related stress tolerance in lily.	Proline	68-75	aldehyde dehydrogenase 18 family member A1	Homo sapiens	18-22
28943044-1	2017	Here we show that Pin1, a peptidyl-prolyl cis/trans isomerase which catalyzes the isomerization of phosphorylated Ser/Thr-Pro, is a regulatory molecule of thrombopoiesis.	Proline	122-125	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	18-22
29047268-3	2017	Barley-based beers crafted to remove gluten using proprietary precipitation and/or application of enzymes, e.g. prolyl endopeptidases (PEP) that degrade the proline-rich gluten molecules, are available commercially.	Proline	157-164	prolyl endopeptidase	Homo sapiens	135-138
29126407-7	2017	RESULTS: Patients with Arg/Arg and Arg/Pro at codon 72 of TP53 had a higher complete response rate (61% vs. 44%, P = 0.007) than those with Pro/Pro.	Proline	39-42	tumor protein p53	Homo sapiens	58-62
29126407-8	2017	In the subgroup treated with CHOP or CHOP-like therapy, patients with Arg/Arg and Arg/Pro showed a higher 5-year overall survival (OS) rate than those with Pro/Pro (68.8% vs. 23.2%, P = 0.001).	Proline	86-89	DNA damage inducible transcript 3	Homo sapiens	29-33
28887018-1	2017	Dipeptidyl peptidase 9 (DPP9) is an intracellular N-terminal post-proline-cleaving enzyme whose physiological function remains largely unknown.	Proline	66-73	dipeptidylpeptidase 9	Mus musculus	0-22
28887018-1	2017	Dipeptidyl peptidase 9 (DPP9) is an intracellular N-terminal post-proline-cleaving enzyme whose physiological function remains largely unknown.	Proline	66-73	dipeptidylpeptidase 9	Mus musculus	24-28
29126407-8	2017	In the subgroup treated with CHOP or CHOP-like therapy, patients with Arg/Arg and Arg/Pro showed a higher 5-year overall survival (OS) rate than those with Pro/Pro (68.8% vs. 23.2%, P = 0.001).	Proline	86-89	DNA damage inducible transcript 3	Homo sapiens	37-41
29416601-4	2018	Structurally, this mutation most likely impairs PROM1 protein stability, flexibility, and amino acid interaction network after changing the amino acid residue Leucine into Proline in the basic helix-loop-helix leucine zipper domain.	Proline	172-179	prominin 1	Homo sapiens	48-53
28753207-0	2017	The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage.	Proline	4-11	transformation related protein 53, pseudogene	Mus musculus	27-30
29116080-2	2017	Previously, a SCA5 mutation resulting in a leucine-to-proline substitution (L253P) in the actin-binding domain (ABD) was shown to cause a 1000-fold increase in actin-binding affinity.	Proline	54-61	spectrin beta, non-erythrocytic 2	Homo sapiens	14-18
29109421-0	2017	High-level heterologous production and Functional Secretion by recombinant Pichia pastoris of the shortest proline-rich antibacterial honeybee peptide Apidaecin.	Proline	107-114	LOC406115	Apis mellifera	151-160
29100052-0	2017	Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P. Ribosomes synthesizing proteins containing consecutive proline residues become stalled and require rescue via the action of uniquely modified translation elongation factors, EF-P in bacteria, or archaeal/eukaryotic a/eIF5A.	Proline	25-32	tripartite motif containing 25	Homo sapiens	108-112
29100052-0	2017	Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P. Ribosomes synthesizing proteins containing consecutive proline residues become stalled and require rescue via the action of uniquely modified translation elongation factors, EF-P in bacteria, or archaeal/eukaryotic a/eIF5A.	Proline	25-32	eukaryotic translation initiation factor 5A	Homo sapiens	331-336
28863383-2	2017	Previous studies suggested that this group of compounds affect prolidase activity (proline releasing enzyme from imidodipeptides) and collagen biosynthesis (proline utilizing process) providing substrate (proline) for proline oxidase (POX) dependent apoptosis.	Proline	83-90	peptidase D	Homo sapiens	63-72
28863383-2	2017	Previous studies suggested that this group of compounds affect prolidase activity (proline releasing enzyme from imidodipeptides) and collagen biosynthesis (proline utilizing process) providing substrate (proline) for proline oxidase (POX) dependent apoptosis.	Proline	83-90	proline dehydrogenase 1	Homo sapiens	218-233
28863383-2	2017	Previous studies suggested that this group of compounds affect prolidase activity (proline releasing enzyme from imidodipeptides) and collagen biosynthesis (proline utilizing process) providing substrate (proline) for proline oxidase (POX) dependent apoptosis.	Proline	157-164	proline dehydrogenase 1	Homo sapiens	218-233
28863383-2	2017	Previous studies suggested that this group of compounds affect prolidase activity (proline releasing enzyme from imidodipeptides) and collagen biosynthesis (proline utilizing process) providing substrate (proline) for proline oxidase (POX) dependent apoptosis.	Proline	157-164	proline dehydrogenase 1	Homo sapiens	235-238
28863383-10	2017	The data suggest that massive production of proline by proBet-dependent activation of prolidase and inhibition of proline utilization for collagen biosynthesis may represent mechanism for POX-dependent apoptosis in EA cells.	Proline	44-51	peptidase D	Homo sapiens	86-95
28863383-10	2017	The data suggest that massive production of proline by proBet-dependent activation of prolidase and inhibition of proline utilization for collagen biosynthesis may represent mechanism for POX-dependent apoptosis in EA cells.	Proline	44-51	proline dehydrogenase 1	Homo sapiens	188-191
28753207-2	2017	A mutant p53, lacking a proline-rich domain (p53DeltaP), that is deficient in controlling both cell death and cell cycle arrest, was employed to determine the biological means by which p53 mediates survival upon DNA damage.	Proline	24-31	transformation related protein 53, pseudogene	Mus musculus	9-12
29163216-3	2017	However, oxaliplatin interrupts hydroxylation of a proline residue located in the N-terminal region of TRPA1 via inhibition of prolyl hydroxylase (PHD), which causes sensitization of TRPA1 to reactive oxygen species (ROS).	Proline	51-58	transient receptor potential cation channel subfamily A member 1	Homo sapiens	103-108
29163216-3	2017	However, oxaliplatin interrupts hydroxylation of a proline residue located in the N-terminal region of TRPA1 via inhibition of prolyl hydroxylase (PHD), which causes sensitization of TRPA1 to reactive oxygen species (ROS).	Proline	51-58	transient receptor potential cation channel subfamily A member 1	Homo sapiens	183-188
29066539-6	2017	During T cell activation, CD46 was recruited to the immune synapse in a manner that required its serine-, threonine-, and proline-rich (STP) region, which is rich in O-glycosylation sites.	Proline	122-129	CD46 molecule	Homo sapiens	26-30
28973299-5	2017	Moreover, strong binding of RG-I-4 to the Gal-3 NT occurs on a very slow time scale, suggesting that it may be mediated by cis-trans proline isomerization, a well-recognized modulator of many biological activities.	Proline	133-140	galectin 3	Homo sapiens	42-47
28895067-7	2017	In addition, palmitic acid, L-proline, and ribitol were decreased in the liver of DPPIV- strain.	Proline	28-37	dipeptidylpeptidase 4	Rattus norvegicus	82-87
28366933-4	2017	We have now demonstrated that the SH3 domain of AHI-1 and the proline rich domain of DNM2 are mainly responsible for this interaction.	Proline	62-69	Abelson helper integration site 1	Homo sapiens	48-53
28366933-4	2017	We have now demonstrated that the SH3 domain of AHI-1 and the proline rich domain of DNM2 are mainly responsible for this interaction.	Proline	62-69	dynamin 2	Homo sapiens	85-89
29058647-5	2017	We found that Gat1 plays an important role in the induction of UGA4 transcription by GABA and that Gzf3 has an effect in cells grown in a poor nitrogen source such as proline and that this effect is positive on UGA4 expression.	Proline	167-174	Gzf3p	Saccharomyces cerevisiae S288C	99-103
28973299-0	2017	Novel polysaccharide binding to the N-terminal tail of galectin-3 is likely modulated by proline isomerization.	Proline	89-96	galectin 3	Homo sapiens	55-65
28526934-0	2017	Exogenous proline stimulates type I collagen and HIF-1alpha expression and the process is attenuated by glutamine in human skin fibroblasts.	Proline	10-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	collagen type XI alpha 2 chain	Homo sapiens	145-149
28737888-0	2017	Discovery of Novel Proline-Based Neuropeptide FF Receptor Antagonists.	Proline	19-26	neuropeptide FF-amide peptide precursor	Rattus norvegicus	33-48
28737888-2	2017	In this study, we report the discovery of a novel proline scaffold with antagonistic activity at the NPFF receptors through a high throughput screening campaign using a functional calcium mobilization assay.	Proline	50-57	neuropeptide FF-amide peptide precursor	Rattus norvegicus	101-105
28737888-7	2017	Together, these results point to the potential of these proline analogs as promising NPFF receptor antagonists.	Proline	56-63	neuropeptide FF-amide peptide precursor	Rattus norvegicus	85-89
28810191-1	2017	The vasoactive proline-rich oligopeptide termed BPP-BrachyNH2 (H-WPPPKVSP-NH2) induces in vitro inhibitory activity of angiotensin I-converting enzyme (ACE) in rat blood serum.	Proline	15-22	angiotensin I converting enzyme	Homo sapiens	119-150
28810191-1	2017	The vasoactive proline-rich oligopeptide termed BPP-BrachyNH2 (H-WPPPKVSP-NH2) induces in vitro inhibitory activity of angiotensin I-converting enzyme (ACE) in rat blood serum.	Proline	15-22	angiotensin I converting enzyme	Homo sapiens	152-155
28810191-9	2017	Thus, the removal of C-terminal proline residue was able to markedly decrease both the BPP-BrachyNH2-induced ACE inhibitory and cytotoxic effects assessed by in vitro and in silico approaches.	Proline	32-39	angiotensin I converting enzyme	Homo sapiens	109-112
29051562-7	2017	However, the behavioral defects caused by wild-type tau can be suppressed when beta-sheet breaking proline residues are introduced in the microtubule-binding domain of tau.	Proline	99-106	microtubule associated protein tau	Homo sapiens	52-55
29051562-7	2017	However, the behavioral defects caused by wild-type tau can be suppressed when beta-sheet breaking proline residues are introduced in the microtubule-binding domain of tau.	Proline	99-106	microtubule associated protein tau	Homo sapiens	168-171
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	BCL2 apoptosis regulator	Homo sapiens	151-156
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	cyclin A2	Homo sapiens	168-176
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	cyclin dependent kinase 2	Homo sapiens	178-182
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	E2F transcription factor 1	Homo sapiens	184-188
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	192-195
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	signal transducer and activator of transcription 3	Homo sapiens	199-204
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	206-211
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	suppressor of cytokine signaling 1	Homo sapiens	230-236
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	signal transducer and activator of transcription 3	Homo sapiens	292-297
29089960-7	2017	In this article, it is studied in detail in five Arabidopsis thaliana proteins using mass spectrometry data: one of them (At4g38770, AtPRP4) is a structural CWP containing 32.5% of Pro residues arranged in typical motifs, the others are either rich (27-28%, At1g31580 and At2g10940) or poor (6-8%, At1g09750 and At3g08030) in Pro residues.	Proline	181-184	proline-rich protein 4	Arabidopsis thaliana	133-139
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	cyclin dependent kinase 2	Homo sapiens	303-307
29089960-7	2017	In this article, it is studied in detail in five Arabidopsis thaliana proteins using mass spectrometry data: one of them (At4g38770, AtPRP4) is a structural CWP containing 32.5% of Pro residues arranged in typical motifs, the others are either rich (27-28%, At1g31580 and At2g10940) or poor (6-8%, At1g09750 and At3g08030) in Pro residues.	Proline	326-329	proline-rich protein 4	Arabidopsis thaliana	133-139
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	vascular endothelial growth factor A	Homo sapiens	311-315
29254203-4	2017	Notably, PROS inhibited VEGF induced proliferation, migration and tube formation in HUVECs and suppressed angiogenesis in chorioallantoic membrane (CAM) assay via reduced phosphorylation of VEGFR2, Src and STAT3.	Proline	9-13	vascular endothelial growth factor A	Homo sapiens	24-28
29254203-4	2017	Notably, PROS inhibited VEGF induced proliferation, migration and tube formation in HUVECs and suppressed angiogenesis in chorioallantoic membrane (CAM) assay via reduced phosphorylation of VEGFR2, Src and STAT3.	Proline	9-13	kinase insert domain receptor	Homo sapiens	190-196
29254203-4	2017	Notably, PROS inhibited VEGF induced proliferation, migration and tube formation in HUVECs and suppressed angiogenesis in chorioallantoic membrane (CAM) assay via reduced phosphorylation of VEGFR2, Src and STAT3.	Proline	9-13	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	198-201
29254203-4	2017	Notably, PROS inhibited VEGF induced proliferation, migration and tube formation in HUVECs and suppressed angiogenesis in chorioallantoic membrane (CAM) assay via reduced phosphorylation of VEGFR2, Src and STAT3.	Proline	9-13	signal transducer and activator of transcription 3	Homo sapiens	206-211
29254203-5	2017	Consistently, PROS reduced the growth of H460 cells implanted in BALB/c athymic nude mice via inhibition of STAT3, and VEGF and activation of caspase 3.	Proline	14-18	signal transducer and activator of transcription 3	Mus musculus	108-113
29254203-5	2017	Consistently, PROS reduced the growth of H460 cells implanted in BALB/c athymic nude mice via inhibition of STAT3, and VEGF and activation of caspase 3.	Proline	14-18	vascular endothelial growth factor A	Mus musculus	119-123
29254203-5	2017	Consistently, PROS reduced the growth of H460 cells implanted in BALB/c athymic nude mice via inhibition of STAT3, and VEGF and activation of caspase 3.	Proline	14-18	caspase 3	Mus musculus	142-151
28712849-3	2017	FAD-dependent proline dehydrogenase (PRODH) and NAD+-dependent glutamate semialdehyde dehydrogenase (GSALDH) convert proline to glutamate in two sequential oxidative steps.	Proline	14-21	proline dehydrogenase 1	Homo sapiens	37-42
29035420-6	2017	The presence of Iva and the noncanonical proline analogue cis-3-amino-L-proline (ALP) in both peptaibols induces helical structures.	Proline	41-48	suppressor of cytokine signaling 3	Homo sapiens	58-63
29023495-3	2017	Yeast Nab3 is one such protein that contains RNA-binding domains and a low complexity, glutamine/proline-rich, prion-like domain that can self-assemble.	Proline	97-104	Nab3p	Saccharomyces cerevisiae S288C	6-10
28949522-2	2017	Two peptides CP++ and sCP++ are designed with a sequence comprising a central block (Pro-Hyp-Gly) and two positively charged domains (Pro-Arg-Gly) at both N- and C-termini.	Proline	85-88	urocortin 3	Homo sapiens	22-25
29038531-2	2017	We have previously established that the membrane receptor FGFR2 drives LUAD progression through aberrant protein-protein interactions mediated via its C-terminal proline-rich motif.	Proline	162-169	fibroblast growth factor receptor 2	Homo sapiens	58-63
29038531-3	2017	Here we report that the N-terminal ankyrin repeats of TRPA1 directly bind to the C-terminal proline-rich motif of FGFR2 inducing the constitutive activation of the receptor, thereby prompting LUAD progression and metastasis.	Proline	92-99	transient receptor potential cation channel subfamily A member 1	Homo sapiens	54-59
29038531-3	2017	Here we report that the N-terminal ankyrin repeats of TRPA1 directly bind to the C-terminal proline-rich motif of FGFR2 inducing the constitutive activation of the receptor, thereby prompting LUAD progression and metastasis.	Proline	92-99	fibroblast growth factor receptor 2	Homo sapiens	114-119
28251507-7	2017	These residues are flanked by prolines (P250, P258, P260, and P268), suggesting proline cis-trans isomerization.	Proline	30-38	TATA-box binding protein associated factor 1	Mus musculus	40-44
29037142-6	2017	Using this novel approach, no PHD3 activity toward HIF3 was demonstrated, indirectly pointing to the hydroxylation of the second proline in 564PYIP567 (HIF1) catalyzed by this isozyme.	Proline	129-136	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-156
28251507-7	2017	These residues are flanked by prolines (P250, P258, P260, and P268), suggesting proline cis-trans isomerization.	Proline	30-37	TATA-box binding protein associated factor 1	Mus musculus	40-44
27989597-1	2017	Vertebrate ALDH18A1 genes encode a bifunctional mitochondrial enzyme, catalyzing a 2-step conversion of glutamate to glutamyl semialdehyde, subsequently converted into proline, ornithine and arginine.	Proline	168-175	aldehyde dehydrogenase 18 family, member A1	Rattus norvegicus	11-19
28756863-0	2017	Proline dehydrogenase-entrapped mesoporous magnetic silica nanomaterial for electrochemical biosensing of L-proline in biological fluids.	Proline	106-115	proline dehydrogenase	Mus musculus	0-21
28863833-5	2017	The membrane proximal proline-rich motif of the cytoplasmic domain of both IL-5R alpha and betac subunits is essential for IL-5 signal transduction.	Proline	22-29	interleukin 5 receptor, alpha	Mus musculus	75-86
28863833-5	2017	The membrane proximal proline-rich motif of the cytoplasmic domain of both IL-5R alpha and betac subunits is essential for IL-5 signal transduction.	Proline	22-29	interleukin 5	Mus musculus	75-79
28756863-5	2017	The electrocatalytic current response of proline dehydrogenase entrapped in a magnetic mesoporous silica nanomaterial toward oxidation of L-proline was maintained in the analytical solution temperature up to 70 C. The entrapped proline dehydrogenase was casted onto a polycysteine-modified glassy carbon electrode.	Proline	138-147	proline dehydrogenase	Mus musculus	41-62
28756863-5	2017	The electrocatalytic current response of proline dehydrogenase entrapped in a magnetic mesoporous silica nanomaterial toward oxidation of L-proline was maintained in the analytical solution temperature up to 70 C. The entrapped proline dehydrogenase was casted onto a polycysteine-modified glassy carbon electrode.	Proline	138-147	proline dehydrogenase	Mus musculus	228-249
28656506-0	2017	Comparing naturally occurring glycosylated forms of proline rich antibacterial peptide, Drosocin.	Proline	52-59	Drosocin	Drosophila melanogaster	88-96
28656506-3	2017	Drosocin, a 19 amino acid glycosylated AMP is a member of proline rich class, synthesized in the haemolymph of Drosophila melanogaster upon bacterial challenge.	Proline	58-65	Drosocin	Drosophila melanogaster	0-8
28791779-5	2017	Mutational analyses of Nup42p showed that the conserved serines and prolines in the SxFG/PxFG repeats contribute to Xpo1p-Nup42p binding.	Proline	68-76	FG-nucleoporin NUP42	Saccharomyces cerevisiae S288C	23-29
27800612-1	2017	Pin1 is a peptidyl prolyl cis-trans isomerase that specifically binds to the phosphoserine-proline or phosphothreonine-proline motifs of several proteins.	Proline	91-98	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
28791779-5	2017	Mutational analyses of Nup42p showed that the conserved serines and prolines in the SxFG/PxFG repeats contribute to Xpo1p-Nup42p binding.	Proline	68-76	exportin CRM1	Saccharomyces cerevisiae S288C	116-121
28791779-5	2017	Mutational analyses of Nup42p showed that the conserved serines and prolines in the SxFG/PxFG repeats contribute to Xpo1p-Nup42p binding.	Proline	68-76	FG-nucleoporin NUP42	Saccharomyces cerevisiae S288C	122-128
28540407-6	2017	This homogyzous mutation caused a substitution of the 69th amino acid of the AIRE protein from glutamine to proline (p.Q69P).	Proline	108-115	autoimmune regulator	Homo sapiens	77-81
29308362-6	2017	Molecular analysis of p53 codon 72 gene polymorphism was performed by polymerase chain reaction - restriction fragment length polymorphism for Arg/Arg, Arg/Pro, and Pro/Pro.	Proline	156-159	tumor protein p53	Homo sapiens	22-25
29308362-6	2017	Molecular analysis of p53 codon 72 gene polymorphism was performed by polymerase chain reaction - restriction fragment length polymorphism for Arg/Arg, Arg/Pro, and Pro/Pro.	Proline	165-168	tumor protein p53	Homo sapiens	22-25
29308362-6	2017	Molecular analysis of p53 codon 72 gene polymorphism was performed by polymerase chain reaction - restriction fragment length polymorphism for Arg/Arg, Arg/Pro, and Pro/Pro.	Proline	165-168	tumor protein p53	Homo sapiens	22-25
27800612-1	2017	Pin1 is a peptidyl prolyl cis-trans isomerase that specifically binds to the phosphoserine-proline or phosphothreonine-proline motifs of several proteins.	Proline	119-126	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
28791342-0	2017	Generation of a novel TRAIL mutant by proline to arginine substitution based on codon bias and its antitumor effects.	Proline	38-45	TNF superfamily member 10	Homo sapiens	22-27
29085449-1	2017	Proline rich 11 (PRR11) serves an important role in the development and progression of a number of types of human cancer.	Proline	0-7	proline rich 11	Homo sapiens	17-22
28905065-4	2017	This has lead to biotechnological development of drugs for adjunct therapies of T2D, such as pramlintide, a variant of hIAPP inspired by rIAPP whose proline substitutions have beta-strand fibril-breaking properties.	Proline	149-156	islet amyloid polypeptide	Homo sapiens	119-124
28707340-6	2017	A TPR consensus proline residue present in human Fis1 is absent in the yeast molecule and, when added, prevents yeast Fis1 dimerization suggesting that the TPR consensus proline might have persisted to prevent TPR oligomerization.	Proline	16-23	fission, mitochondrial 1	Homo sapiens	49-53
28707340-6	2017	A TPR consensus proline residue present in human Fis1 is absent in the yeast molecule and, when added, prevents yeast Fis1 dimerization suggesting that the TPR consensus proline might have persisted to prevent TPR oligomerization.	Proline	16-23	Fis1p	Saccharomyces cerevisiae S288C	118-122
28707340-6	2017	A TPR consensus proline residue present in human Fis1 is absent in the yeast molecule and, when added, prevents yeast Fis1 dimerization suggesting that the TPR consensus proline might have persisted to prevent TPR oligomerization.	Proline	170-177	fission, mitochondrial 1	Homo sapiens	49-53
28707340-6	2017	A TPR consensus proline residue present in human Fis1 is absent in the yeast molecule and, when added, prevents yeast Fis1 dimerization suggesting that the TPR consensus proline might have persisted to prevent TPR oligomerization.	Proline	170-177	Fis1p	Saccharomyces cerevisiae S288C	118-122
29038364-4	2017	Oral absorption was measured in the presence of substrates for the proton-coupled amino acid transporter, PAT1, that is, 200 mg/kg proline (Pro) and sarcosine (Sar), and in the presence of 2-Amino-2-norbornanecarboxylic acid (BCH) (200 mg/kg).	Proline	131-138	solute carrier family 36 member 1	Homo sapiens	106-110
28953919-3	2017	In one family, a proline residue within the C2B Ca2+-binding pocket of synaptotagmin is replaced by a leucine.	Proline	17-24	Synaptotagmin 1	Drosophila melanogaster	71-84
29156807-6	2017	Proline supplementation but not Smad7-knockdown reversed halofuginone-inhibition of TGF-beta-signaling.	Proline	0-7	transforming growth factor, beta 1	Mus musculus	84-92
29163782-6	2017	BMI1 contains a ring finger, helix-turn, proline/serine domain and two nuclear localization signals (NLS).	Proline	41-48	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	0-4
28916707-3	2017	Here we show pharyngeal gland cell expression of PQN-75, a unique protein containing an N-terminal signal peptide, nucleoporin (Nup)-like phenylalanine/glycine (FG) repeats, and an extensive polyproline repeat domain with similarities to human basic salivary proline-rich pre-protein PRB2.	Proline	195-202	Prion-like-(Q/N-rich)-domain-bearing protein	Caenorhabditis elegans	49-55
28862848-0	2017	Enantioselective Aldol Reactions in Water by a Proline-Derived Cryptand and Fixation of CO2 by Its Exocyclic Co(II) Complex.	Proline	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
28951734-2	2017	Recent study showed that Arabidopsis PIN1-type parvulin 1 (Pin1At) is an important floral activator and regulates floral transition by facilitating the cis/trans isomerization of the phosphorylated Ser/Thr residues preceding proline motifs in suppressor of overexpression of CO 1 (SOC1) and agamous-like 24 (AGL24).	Proline	225-232	Auxin efflux carrier family protein	Arabidopsis thaliana	37-41
28922389-4	2017	Intermediates of proline catabolism were associated with OCN reflecting the implication in bone metabolism.	Proline	17-24	bone gamma-carboxyglutamate protein	Homo sapiens	57-60
28951734-2	2017	Recent study showed that Arabidopsis PIN1-type parvulin 1 (Pin1At) is an important floral activator and regulates floral transition by facilitating the cis/trans isomerization of the phosphorylated Ser/Thr residues preceding proline motifs in suppressor of overexpression of CO 1 (SOC1) and agamous-like 24 (AGL24).	Proline	225-232	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Arabidopsis thaliana	59-65
28481868-5	2017	PIN1 also catalyses the isomerization of proline 205 of BRD4 and induces its conformational change, which promotes its interaction with CDK9 and increases BRD4"s transcriptional activity.	Proline	41-48	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
28481868-5	2017	PIN1 also catalyses the isomerization of proline 205 of BRD4 and induces its conformational change, which promotes its interaction with CDK9 and increases BRD4"s transcriptional activity.	Proline	41-48	bromodomain containing 4	Homo sapiens	56-60
28620826-9	2017	Many amino acids and citric acid cycle intermediates and their ester forms were individually supplemented to the cells with L-serine, L-proline, L-aspartate, or L-glutamine decreasing ROS production in oxidatively stressed alpha-synuclein overexpressing cells, while diethyl oxaloacetate or L-valine supplementation increased ATP levels.	Proline	134-143	synuclein alpha	Homo sapiens	223-238
28873979-1	2017	The Saccharomyces cerevisiae poly(A)-binding protein Pab1 is a modular protein composed of four RNA recognition motifs (RRM), a proline-rich domain (P) and a C-terminus.	Proline	128-135	polyadenylate-binding protein	Saccharomyces cerevisiae S288C	53-57
28382686-4	2017	In cells treated with 0.01, 0.03 and 0.05% MP a dose-dependent decrease in collagen biosynthesis was revealed, which was positively correlated with the activity of prolidase responsible for the recovery of proline.	Proline	206-213	peptidase D	Homo sapiens	164-173
27225727-1	2017	Pin1 is an enzyme that specifically recognizes the peptide bond between phosphorylated serine or threonine (pS/pT-P) and proline.	Proline	121-128	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
28679684-4	2017	Adding a preferred nitrogen source to proline-grown cells triggers Gap1 endocytosis and vacuolar degradation in an Rsp5-Bul1/2-dependent manner.	Proline	38-45	amino acid permease GAP1	Saccharomyces cerevisiae S288C	67-71
28679684-4	2017	Adding a preferred nitrogen source to proline-grown cells triggers Gap1 endocytosis and vacuolar degradation in an Rsp5-Bul1/2-dependent manner.	Proline	38-45	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	115-119
28783324-0	2017	A Noncanonical Binding Site in the EVH1 Domain of Vasodilator-Stimulated Phosphoprotein Regulates Its Interactions with the Proline Rich Region of Zyxin.	Proline	124-131	vasodilator stimulated phosphoprotein	Homo sapiens	50-87
28783324-0	2017	A Noncanonical Binding Site in the EVH1 Domain of Vasodilator-Stimulated Phosphoprotein Regulates Its Interactions with the Proline Rich Region of Zyxin.	Proline	124-131	zyxin	Homo sapiens	147-152
28783324-4	2017	Sequentially close clusters of four or five of these motifs frequently occur, as in the proline rich region of Zyxin with four such motifs.	Proline	88-95	zyxin	Homo sapiens	111-116
28783324-6	2017	Here, quantitative nuclear magnetic resonance titration analysis reveals a dominant bivalent 1:1 (Zyxin:EVH1) interaction between the Zyxin proline rich region and the VASP EVH1 domain that utilizes the EVH1 canonical binding site and a novel secondary binding site on the opposite face of the EVH1 domain.	Proline	140-147	zyxin	Homo sapiens	98-103
28783324-6	2017	Here, quantitative nuclear magnetic resonance titration analysis reveals a dominant bivalent 1:1 (Zyxin:EVH1) interaction between the Zyxin proline rich region and the VASP EVH1 domain that utilizes the EVH1 canonical binding site and a novel secondary binding site on the opposite face of the EVH1 domain.	Proline	140-147	zyxin	Homo sapiens	134-139
28783324-6	2017	Here, quantitative nuclear magnetic resonance titration analysis reveals a dominant bivalent 1:1 (Zyxin:EVH1) interaction between the Zyxin proline rich region and the VASP EVH1 domain that utilizes the EVH1 canonical binding site and a novel secondary binding site on the opposite face of the EVH1 domain.	Proline	140-147	vasodilator stimulated phosphoprotein	Homo sapiens	168-172
28743672-4	2017	RESULTS: The protein sequence of CYP2U1 displayed two unique characteristics when compared to those of the human CYPs, the presence of a longer N-terminal region upstream of the putative trans-membrane helix (TMH) containing 8 proline residues, and of an insert of about 20 amino acids containing 5 arginine residues between helices A" and A.	Proline	227-234	cytochrome P450 family 2 subfamily U member 1	Homo sapiens	33-39
28070831-1	2017	BACKGROUND: Prolyl oligopeptidase (POP, EC 3.4.1.26) is a serine peptidase that hydrolyzes post-proline peptide bonds in peptides that are &lt;30 amino acids in length.	Proline	96-103	prolyl endopeptidase	Homo sapiens	12-33
28070831-1	2017	BACKGROUND: Prolyl oligopeptidase (POP, EC 3.4.1.26) is a serine peptidase that hydrolyzes post-proline peptide bonds in peptides that are &lt;30 amino acids in length.	Proline	96-103	prolyl endopeptidase	Homo sapiens	35-38
28677335-1	2017	Prolidase is a ubiquitously distributed dipeptidase and the only dipeptidase in humans capable of cleaving the peptide bond preceding the amino acids proline (Pro) or hydroxyproline (Hyp).	Proline	150-157	peptidase D	Homo sapiens	0-9
28765275-9	2017	Our results reveal a previously unknown link between Pro metabolism and phosphate nutrition and show that Pro biosynthesis is target of cross talk between ABA signaling and regulation of phosphate homeostasis through PHR1- and PHL1-mediated transcriptional activation of the P5CS1 gene.	Proline	53-56	Homeodomain-like superfamily protein	Arabidopsis thaliana	227-231
28713944-1	2017	Truncated apolipoprotein C-I is a post-translationally modified protein characterized by the loss of threonine and proline residues from the N-terminus of the mature peptide.	Proline	115-122	apolipoprotein C-I	Mus musculus	10-28
28765275-9	2017	Our results reveal a previously unknown link between Pro metabolism and phosphate nutrition and show that Pro biosynthesis is target of cross talk between ABA signaling and regulation of phosphate homeostasis through PHR1- and PHL1-mediated transcriptional activation of the P5CS1 gene.	Proline	53-56	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	275-280
28743736-3	2017	In this study, we investigated the transcriptional regulation of PDE3A , and found that the splicing factor proline and glutamine rich (SFPQ) protein modulated PDE3A mRNA levels.	Proline	108-115	phosphodiesterase 3A	Homo sapiens	65-70
28743736-3	2017	In this study, we investigated the transcriptional regulation of PDE3A , and found that the splicing factor proline and glutamine rich (SFPQ) protein modulated PDE3A mRNA levels.	Proline	108-115	splicing factor proline and glutamine rich	Homo sapiens	136-140
28743736-3	2017	In this study, we investigated the transcriptional regulation of PDE3A , and found that the splicing factor proline and glutamine rich (SFPQ) protein modulated PDE3A mRNA levels.	Proline	108-115	phosphodiesterase 3A	Homo sapiens	160-165
28666866-8	2017	We report that the WW1 domain of NEDD4-1 recognizes the SERTA domain containing the proline rich region (PRR motif) in p34SEI-1.	Proline	84-91	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	33-40
28851822-9	2017	The proline-rich region and kinase domain of Pkn3 were required to restore the bone-resorbing activity of osteoclasts derived from Pkn3-/- mice.	Proline	4-11	protein kinase N3	Mus musculus	131-135
28852021-1	2017	Elongation factor eIF5A is required for the translation of consecutive prolines, and was shown in yeast to translate polyproline-containing Bni1, an actin-nucleating formin required for polarized growth during mating.	Proline	71-79	eukaryotic translation initiation factor 5A	Homo sapiens	18-23
28637321-4	2017	Though most proline analogs require eIF5A for efficient peptide synthesis, azetidine-2-caboxylic acid, a more flexible four-membered ring derivative of proline, shows relaxed eIF5A dependency, indicating that the structural rigidity of proline might contribute to the requirement for eIF5A.	Proline	152-159	eukaryotic translation initiation factor 5A	Homo sapiens	175-180
28625920-8	2017	Data from pull-down assay between the Noxo1 and Noxa1 showed that the SH3 domains (Noxa1) is responsible for interaction with Noxo1 C-terminal tail harboring proline rich region (PRR).	Proline	158-165	NADPH oxidase organizer 1	Homo sapiens	38-43
28625920-8	2017	Data from pull-down assay between the Noxo1 and Noxa1 showed that the SH3 domains (Noxa1) is responsible for interaction with Noxo1 C-terminal tail harboring proline rich region (PRR).	Proline	158-165	NADPH oxidase activator 1	Homo sapiens	48-53
28625920-8	2017	Data from pull-down assay between the Noxo1 and Noxa1 showed that the SH3 domains (Noxa1) is responsible for interaction with Noxo1 C-terminal tail harboring proline rich region (PRR).	Proline	158-165	NADPH oxidase activator 1	Homo sapiens	83-88
28625920-8	2017	Data from pull-down assay between the Noxo1 and Noxa1 showed that the SH3 domains (Noxa1) is responsible for interaction with Noxo1 C-terminal tail harboring proline rich region (PRR).	Proline	158-165	NADPH oxidase organizer 1	Homo sapiens	126-131
28637321-7	2017	Thus, we propose that the body of eIF5A functionally substitutes for polyamines to promote general protein synthesis and that the hypusine modification on eIF5A is critically important for poor substrates like proline.	Proline	210-217	eukaryotic translation initiation factor 5A	Homo sapiens	155-160
28637321-4	2017	Though most proline analogs require eIF5A for efficient peptide synthesis, azetidine-2-caboxylic acid, a more flexible four-membered ring derivative of proline, shows relaxed eIF5A dependency, indicating that the structural rigidity of proline might contribute to the requirement for eIF5A.	Proline	152-159	eukaryotic translation initiation factor 5A	Homo sapiens	175-180
28637321-4	2017	Though most proline analogs require eIF5A for efficient peptide synthesis, azetidine-2-caboxylic acid, a more flexible four-membered ring derivative of proline, shows relaxed eIF5A dependency, indicating that the structural rigidity of proline might contribute to the requirement for eIF5A.	Proline	152-159	eukaryotic translation initiation factor 5A	Homo sapiens	175-180
28637321-4	2017	Though most proline analogs require eIF5A for efficient peptide synthesis, azetidine-2-caboxylic acid, a more flexible four-membered ring derivative of proline, shows relaxed eIF5A dependency, indicating that the structural rigidity of proline might contribute to the requirement for eIF5A.	Proline	152-159	eukaryotic translation initiation factor 5A	Homo sapiens	175-180
28607151-7	2017	We found that, via its glutamine- and serine/proline-rich domains, TLE3 interferes with MyoD function by disrupting the association between the basic helix-loop-helix domain of MyoD and E proteins.	Proline	45-52	TLE family member 3, transcriptional corepressor	Homo sapiens	67-71
28607151-7	2017	We found that, via its glutamine- and serine/proline-rich domains, TLE3 interferes with MyoD function by disrupting the association between the basic helix-loop-helix domain of MyoD and E proteins.	Proline	45-52	myogenic differentiation 1	Homo sapiens	88-92
28607151-7	2017	We found that, via its glutamine- and serine/proline-rich domains, TLE3 interferes with MyoD function by disrupting the association between the basic helix-loop-helix domain of MyoD and E proteins.	Proline	45-52	myogenic differentiation 1	Homo sapiens	177-181
28646315-7	2017	Biochemical analyses followed by phenotypic studies demonstrated that AtCBF3 plants exhibited membrane stability and lush green appearance by limiting membrane ions leakage and malondialdehyde contents and by accumulating more proline, soluble sugars, chlorophyll contents, carotenoid contents, and antioxidant enzymes relative to wild type plants.	Proline	227-234	dehydration response element B1A	Arabidopsis thaliana	70-76
28777093-1	2017	C4.4A is a glycosylphosphatidylinositol-anchored membrane protein comprised of two LU domains (Ly6/uPAR-like domains) and an extensively O-glycosylated C-terminal Ser/Thr/Pro-rich region.	Proline	171-174	LY6/PLAUR domain containing 3	Homo sapiens	0-5
28499919-4	2017	Further mechanistic studies revealed that AC023115.3 acts as a competing endogenous RNA for miR-26a and attenuates the inhibitory effect of miR-26a on GSK3beta, a proline-directed serine-threonine kinase that promotes the degradation of Mcl1, leading to an increase in GSK3beta and a decrease in autophagy.	Proline	163-170	microRNA 26a-1	Homo sapiens	92-99
28499919-4	2017	Further mechanistic studies revealed that AC023115.3 acts as a competing endogenous RNA for miR-26a and attenuates the inhibitory effect of miR-26a on GSK3beta, a proline-directed serine-threonine kinase that promotes the degradation of Mcl1, leading to an increase in GSK3beta and a decrease in autophagy.	Proline	163-170	microRNA 26a-1	Homo sapiens	140-147
28499919-4	2017	Further mechanistic studies revealed that AC023115.3 acts as a competing endogenous RNA for miR-26a and attenuates the inhibitory effect of miR-26a on GSK3beta, a proline-directed serine-threonine kinase that promotes the degradation of Mcl1, leading to an increase in GSK3beta and a decrease in autophagy.	Proline	163-170	glycogen synthase kinase 3 beta	Homo sapiens	151-159
28499919-4	2017	Further mechanistic studies revealed that AC023115.3 acts as a competing endogenous RNA for miR-26a and attenuates the inhibitory effect of miR-26a on GSK3beta, a proline-directed serine-threonine kinase that promotes the degradation of Mcl1, leading to an increase in GSK3beta and a decrease in autophagy.	Proline	163-170	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	237-241
28499919-4	2017	Further mechanistic studies revealed that AC023115.3 acts as a competing endogenous RNA for miR-26a and attenuates the inhibitory effect of miR-26a on GSK3beta, a proline-directed serine-threonine kinase that promotes the degradation of Mcl1, leading to an increase in GSK3beta and a decrease in autophagy.	Proline	163-170	glycogen synthase kinase 3 beta	Homo sapiens	269-277
28625716-3	2017	Hypoxia inducible transcription factor prolyl hydroxylase 2 (HIF-PHD2), as the key regulator of hypoxia response, is function of hydroxylating specify proline residues of HIF-alpha, which may lead to the degradation of HIF-alpha and eventually cause disenabling the expression of erythropoietin.	Proline	151-158	egl-9 family hypoxia inducible factor 1	Homo sapiens	65-69
28625716-3	2017	Hypoxia inducible transcription factor prolyl hydroxylase 2 (HIF-PHD2), as the key regulator of hypoxia response, is function of hydroxylating specify proline residues of HIF-alpha, which may lead to the degradation of HIF-alpha and eventually cause disenabling the expression of erythropoietin.	Proline	151-158	erythropoietin	Homo sapiens	280-294
28317757-3	2017	Sequences of ACE-inhibitory peptides are composed of hydrophobic (proline) and aliphatic amino acids (isoleucine and leucine) at the N-terminus.	Proline	66-73	angiotensin I converting enzyme	Homo sapiens	13-16
28679296-1	2017	INTRODUCTION: The mammalian SPS1-related proline/alanine-rich serine-threonine kinase SPAK (STK39) modulates ion transport across and between epithelial cells in response to environmental stimuli such osmotic stress and inflammation.	Proline	41-48	selenophosphate synthetase 1	Homo sapiens	28-32
28679296-1	2017	INTRODUCTION: The mammalian SPS1-related proline/alanine-rich serine-threonine kinase SPAK (STK39) modulates ion transport across and between epithelial cells in response to environmental stimuli such osmotic stress and inflammation.	Proline	41-48	serine/threonine kinase 39	Homo sapiens	86-90
28679296-1	2017	INTRODUCTION: The mammalian SPS1-related proline/alanine-rich serine-threonine kinase SPAK (STK39) modulates ion transport across and between epithelial cells in response to environmental stimuli such osmotic stress and inflammation.	Proline	41-48	serine/threonine kinase 39	Homo sapiens	92-97
28419468-0	2017	Activation of the Akt-CREB signalling axis by a proline-rich heptapeptide confers resistance to stress-induced cell death and inflammation.	Proline	48-55	cAMP responsive element binding protein 1	Mus musculus	22-26
27677826-1	2017	Pyrroline-5-carboxylate reductase (P5CR) encoded by PYCR1 gene is a housekeeping enzyme that catalyzes the reduction of P5C to proline using NAD(P)H as the cofactor.	Proline	127-134	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-33
28419468-0	2017	Activation of the Akt-CREB signalling axis by a proline-rich heptapeptide confers resistance to stress-induced cell death and inflammation.	Proline	48-55	thymoma viral proto-oncogene 1	Mus musculus	18-21
27381509-3	2017	The FUS protein binds with karyopherinebeta2 (Kapbeta2) through its proline/tyrosine nuclear localization signal (PY-NLS) that helps in the localization of FUS protein within the nucleus.	Proline	68-75	FUS RNA binding protein	Homo sapiens	4-7
27381509-3	2017	The FUS protein binds with karyopherinebeta2 (Kapbeta2) through its proline/tyrosine nuclear localization signal (PY-NLS) that helps in the localization of FUS protein within the nucleus.	Proline	68-75	FUS RNA binding protein	Homo sapiens	156-159
27677826-1	2017	Pyrroline-5-carboxylate reductase (P5CR) encoded by PYCR1 gene is a housekeeping enzyme that catalyzes the reduction of P5C to proline using NAD(P)H as the cofactor.	Proline	127-134	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-39
27677826-1	2017	Pyrroline-5-carboxylate reductase (P5CR) encoded by PYCR1 gene is a housekeeping enzyme that catalyzes the reduction of P5C to proline using NAD(P)H as the cofactor.	Proline	127-134	pyrroline-5-carboxylate reductase 1	Homo sapiens	52-57
27677826-1	2017	Pyrroline-5-carboxylate reductase (P5CR) encoded by PYCR1 gene is a housekeeping enzyme that catalyzes the reduction of P5C to proline using NAD(P)H as the cofactor.	Proline	127-134	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-38
28727946-4	2017	A low-frequency, nonsynonymous single nucleotide polymorphism (SNP) rs117648444 within the 2nd exon of IFNL4 changes the 70th amino acid from proline to serine resulting in lower activity of the functional IFN-lambda4 protein, thereby increasing HCV clearance rates.	Proline	142-149	interferon lambda 4 (gene/pseudogene)	Homo sapiens	103-108
28727946-4	2017	A low-frequency, nonsynonymous single nucleotide polymorphism (SNP) rs117648444 within the 2nd exon of IFNL4 changes the 70th amino acid from proline to serine resulting in lower activity of the functional IFN-lambda4 protein, thereby increasing HCV clearance rates.	Proline	142-149	interferon lambda 4 (gene/pseudogene)	Homo sapiens	206-217
28753126-2	2017	Proper gp160 folding in the ER requires core glycosylation, disulfide-bond formation and proline isomerization.	Proline	89-96	glutamyl aminopeptidase	Homo sapiens	7-12
28789369-5	2017	Notably, the Pro72 allele was significantly enriched in patients with ESCC compared with its abundance in the healthy control group, and the genotype of Pro/Arg on p53 codon 72 was confirmed to exhibit a significant correlation with ESCC in Mongolian patients.	Proline	13-16	tumor protein p53	Homo sapiens	164-167
28789369-7	2017	Mongolian patients who carry the partocular genotype of Arg/Pro or Pro/Pro on p53 codon 72 may be more likely to develop ESCC.	Proline	60-63	tumor protein p53	Homo sapiens	78-81
28789369-7	2017	Mongolian patients who carry the partocular genotype of Arg/Pro or Pro/Pro on p53 codon 72 may be more likely to develop ESCC.	Proline	67-70	tumor protein p53	Homo sapiens	78-81
28789369-7	2017	Mongolian patients who carry the partocular genotype of Arg/Pro or Pro/Pro on p53 codon 72 may be more likely to develop ESCC.	Proline	67-70	tumor protein p53	Homo sapiens	78-81
28824679-7	2017	Indeed, salinized (125 mM NaCl, 20 days) 35S::SlWRKY3 tomato plants displayed reduced oxidative stress and proline contents compared to WT.	Proline	107-114	WRKY transcription factor 41	Solanum lycopersicum	46-53
28532645-5	2017	Since the proline may play a role as a helix breaker, this mutation could significantly disturb the transmembrane helix domain-V of PSEN1 and perturb its protein functions.	Proline	10-17	presenilin 1	Homo sapiens	132-137
28532645-7	2017	Several leucine>proline substitutions in other PSEN1 transmembrane helices revealed aggressive AD phenotypes.	Proline	16-23	presenilin 1	Homo sapiens	47-52
28630300-4	2017	Here, we show that G9a protein stability is increased in hypoxia via reduced proline hydroxylation and, hence, inefficient degradation by the proteasome.	Proline	77-84	euchromatic histone lysine methyltransferase 2	Homo sapiens	19-22
28607150-3	2017	For instance, in bone, AChE exists as a proline-rich membrane anchor (PRiMA)-linked globular form in osteoblasts, in which it is proposed to play a noncholinergic role in differentiation.	Proline	40-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	23-27
28607150-3	2017	For instance, in bone, AChE exists as a proline-rich membrane anchor (PRiMA)-linked globular form in osteoblasts, in which it is proposed to play a noncholinergic role in differentiation.	Proline	40-47	proline rich membrane anchor 1	Homo sapiens	70-75
28702574-5	2017	Inspired by this, these sensing systems can be utilized to design OR, XOR and INHIBIT logic gates, which would be used for the determination of dopamine, proline and ethylene blue via logic outputs.	Proline	154-161	xanthine dehydrogenase	Homo sapiens	70-73
28513914-3	2017	Proline and acid groups appended to catalytic fibers of two self-sorting hydrogelators compete for the Mannich reaction between aniline, benzaldehyde, and cyclohexanone to give low overall selectivity (anti/syn 77:23).	Proline	0-7	synemin	Homo sapiens	207-210
28513914-4	2017	In a sol-gel system of the same molecules, on the other hand, the soluble acid appended molecules tend to cooperate with the fibers of proline-appended catalyst to give improved selectivity (anti/syn 95:5).	Proline	135-142	synemin	Homo sapiens	196-199
28368408-5	2017	We previously showed that T172 phosphorylation of CDK4 is conditioned by an adjacent proline (P173), which is not present in CDK6 and CDK1/2.	Proline	85-92	cyclin dependent kinase 4	Homo sapiens	50-54
28592489-1	2017	Individuals with Hajdu-Cheney syndrome (HCS) present with osteoporosis, and HCS is associated with NOTCH2 mutations causing deletions of the proline-, glutamic acid-, serine-, and threonine-rich (PEST) domain that are predicted to enhance NOTCH2 stability and cause gain-of-function.	Proline	141-148	notch 2	Mus musculus	99-105
28544138-2	2017	Using an aggregative tau-derived model peptide, Ac-PHF6-NH2 , the substitution of its amino acids with proline, a known efficient beta-breaker, is shown to reduce self-assembly.	Proline	103-110	PHD finger protein 6	Homo sapiens	51-55
28544138-4	2017	Moreover, several of the proline-substituted peptides inhibit the aggregation of Ac-PHF6-NH2 amyloidogenic peptide.	Proline	25-32	PHD finger protein 6	Homo sapiens	84-88
29137268-6	2017	However, an alanine scanning of the proline residues of Gab2 suggests that the intermediate contains some degree of native-like structure, which might play a role for the recognition event to take place.	Proline	36-43	GRB2 associated binding protein 2	Homo sapiens	56-60
28475405-3	2017	A common coding region variant at amino acid 72 of p53 encodes either proline (P72) or arginine (R72).	Proline	70-77	tumor protein p53	Homo sapiens	51-54
28475405-3	2017	A common coding region variant at amino acid 72 of p53 encodes either proline (P72) or arginine (R72).	Proline	70-77	DEAD-box helicase 17	Homo sapiens	79-82
28434921-8	2017	A novel heterozygous missense mutations c.40C &gt; A (p.Pro14Thr) was identified in TBX5 gene exon-2, resulting proline to threonine substitution.	Proline	112-119	T-box transcription factor 5	Homo sapiens	84-88
28701145-5	2017	Using our method, consensus RBP-binding sequences were determined for three RBPs, namely FUS (fused in sarcoma), SFPQ (splicing factor proline and glutamine rich), and SAM68 (Src-Associated substrate in Mitosis 68 kDa).	Proline	135-142	retinol binding protein 4	Homo sapiens	28-31
28547731-0	2017	Proline isomerization in the C-terminal region of HSP27.	Proline	0-7	calcitonin receptor	Homo sapiens	29-46
28547731-0	2017	Proline isomerization in the C-terminal region of HSP27.	Proline	0-7	heat shock protein family B (small) member 1	Homo sapiens	50-55
28547731-6	2017	In NMR spectra of an isolated CTR peptide, we observed similar evidence for isomerization involving proline 182, found within the IPI/V motif.	Proline	100-107	calcitonin receptor	Homo sapiens	30-33
28380689-2	2017	The results show that interaction between the two proteins is energetically favorable and heavily dependent on the MBP proline-rich region (P93-P98) in both aqueous and membrane environments.	Proline	119-126	myelin basic protein	Homo sapiens	115-118
28078743-7	2017	The T140-derived bivalent ligands with the 9- and 12-mer proline linkers showed the most effective inhibition against chemotaxis at 1000 nM, which is even higher than that of known CXCR4 antagonists in the monomer structure.	Proline	57-64	C-X-C motif chemokine receptor 4	Homo sapiens	181-186
27830966-3	2017	Here, we analyzed Proline insertion-deletion polymorphism at amino acid position 704 in the RIZ1 gene and its association with CML.	Proline	18-25	PR/SET domain 2	Homo sapiens	92-96
28380689-4	2017	In the membrane context, the xalpha2-peptide interacts with the Fyn-SH3 domain via the proline-rich region and the beta-sheets of Fyn-SH3, with the latter wrapping around the proline-rich region in a form of a clip.	Proline	87-94	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	64-67
28380689-4	2017	In the membrane context, the xalpha2-peptide interacts with the Fyn-SH3 domain via the proline-rich region and the beta-sheets of Fyn-SH3, with the latter wrapping around the proline-rich region in a form of a clip.	Proline	175-182	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	64-67
28380689-6	2017	This study thus provides a more-detailed glimpse into the context-dependent interaction dynamics and importance of the beta-sheets in Fyn-SH3 and proline-rich region of MBP.	Proline	146-153	myelin basic protein	Homo sapiens	169-172
28670957-1	2017	XPNPEP2 is a proline hydrolytic enzyme that hydrolyzes several biologically active peptides and causes a loss of substrate activity.	Proline	13-20	X-prolyl aminopeptidase 2	Homo sapiens	0-7
28662085-8	2017	Metabolites such as allantoin, creatinine, proline, and methylamine could be predictive of AII/R injury.	Proline	43-50	NLR family pyrin domain containing 3	Homo sapiens	91-94
28476889-7	2017	A wide proline pocket as well as molecular complementarity and capping at the S1 substrate site of XPNPEP3 provide the necessary structural features for processing the mitochondrial substrates.	Proline	7-14	X-prolyl aminopeptidase 3	Homo sapiens	99-106
28598606-3	2017	Here we show, through the use of noncanonical amino acid mutagenesis, that replacement of the proline residue at position 28 of the insulin B-chain (ProB28) by (4S)-hydroxyproline (Hzp) yields an active form of insulin that dissociates more rapidly, and fibrillates more slowly, than the wild-type protein.	Proline	94-101	insulin	Homo sapiens	132-139
28598606-3	2017	Here we show, through the use of noncanonical amino acid mutagenesis, that replacement of the proline residue at position 28 of the insulin B-chain (ProB28) by (4S)-hydroxyproline (Hzp) yields an active form of insulin that dissociates more rapidly, and fibrillates more slowly, than the wild-type protein.	Proline	94-101	insulin	Homo sapiens	211-218
28501621-0	2017	Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline.	Proline	122-131	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	21-43
28501621-1	2017	Prolyl-tRNA synthetase (PRS) is a member of the aminoacyl-tRNA synthetase family of enzymes and catalyzes the synthesis of prolyl-tRNAPro using ATP, l-proline, and tRNAPro as substrates.	Proline	149-158	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	0-22
28501621-1	2017	Prolyl-tRNA synthetase (PRS) is a member of the aminoacyl-tRNA synthetase family of enzymes and catalyzes the synthesis of prolyl-tRNAPro using ATP, l-proline, and tRNAPro as substrates.	Proline	149-158	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	24-27
28501621-7	2017	Thermal shift assays demonstrated the stabilization of PRS in complex with l-proline and pyrazinamide PRS inhibitors.	Proline	75-84	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	55-58
28501621-8	2017	The binding mode of the PRS inhibitor to the ATP site of PRS enzyme was elucidated using the ternary complex crystal structure with l-proline.	Proline	132-141	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	24-27
28501621-8	2017	The binding mode of the PRS inhibitor to the ATP site of PRS enzyme was elucidated using the ternary complex crystal structure with l-proline.	Proline	132-141	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	57-60
28594296-1	2017	Tissue culture and mouse model studies show that the presence of the arginine (R) or proline (P) coding single nucleotide polymorphism (SNP) of the tumor suppressor gene p53 at codon 72 (p53 R72P) differentially affects the responses to genotoxic insult.	Proline	85-92	transformation related protein 53, pseudogene	Mus musculus	170-173
28654636-7	2017	Nuclear magnetic resonance (NMR) revealed that CyP40 interacts with tau at sites rich in proline residues.	Proline	89-96	peptidylprolyl isomerase D (cyclophilin D)	Mus musculus	47-52
28654636-8	2017	CyP40 was also able to interact with and disaggregate other aggregating proteins that contain prolines.	Proline	94-102	peptidylprolyl isomerase D (cyclophilin D)	Mus musculus	0-5
28432100-7	2017	Hrr25 has a 200-residue C-terminal region, including a proline- and glutamine-rich domain.	Proline	55-62	serine/threonine protein kinase HRR25	Saccharomyces cerevisiae S288C	0-5
28594296-1	2017	Tissue culture and mouse model studies show that the presence of the arginine (R) or proline (P) coding single nucleotide polymorphism (SNP) of the tumor suppressor gene p53 at codon 72 (p53 R72P) differentially affects the responses to genotoxic insult.	Proline	85-92	transformation related protein 53, pseudogene	Mus musculus	187-190
29228664-2	2017	Here, we show that MORC2 promoted breast cancer invasion and metastasis and these effects depended on a proline-rich domain (PRD) within its carboxy-terminal region spanning residues 601-734.	Proline	104-111	MORC family CW-type zinc finger 2	Homo sapiens	19-24
28623291-2	2017	The N-terminal of MyRF, which contains a proline-rich region and a DNA binding domain (DBD), is auto-cleaved from the ER membrane, and then enters the nucleus to participate in transcription regulation of the myelin genes.	Proline	41-48	myelin regulatory factor	Homo sapiens	18-22
28663723-9	2017	In addition, the C-terminal proline-rich region of HIP1R responsible for cortactin binding was found to confer a dominant-negative effect on dendritic branching in cultured developing neurons, implying a critical role of cortactin binding in HIP1R function.	Proline	28-35	huntingtin interacting protein 1 related	Rattus norvegicus	51-56
28663723-9	2017	In addition, the C-terminal proline-rich region of HIP1R responsible for cortactin binding was found to confer a dominant-negative effect on dendritic branching in cultured developing neurons, implying a critical role of cortactin binding in HIP1R function.	Proline	28-35	cortactin	Rattus norvegicus	73-82
28663723-9	2017	In addition, the C-terminal proline-rich region of HIP1R responsible for cortactin binding was found to confer a dominant-negative effect on dendritic branching in cultured developing neurons, implying a critical role of cortactin binding in HIP1R function.	Proline	28-35	cortactin	Rattus norvegicus	221-230
28663723-9	2017	In addition, the C-terminal proline-rich region of HIP1R responsible for cortactin binding was found to confer a dominant-negative effect on dendritic branching in cultured developing neurons, implying a critical role of cortactin binding in HIP1R function.	Proline	28-35	huntingtin interacting protein 1 related	Rattus norvegicus	242-247
28190537-11	2017	Both children are homozygous for the novel mutation c.767C&gt;G in exon 5 of the GLYCTK gene, predicted to affect the enzyme by replacing the evolutionarily conserved Proline with Arginine (P256R).	Proline	167-174	glycerate kinase	Homo sapiens	81-87
28446606-6	2017	In the BD-associated ERAP1 context of B*51:08, longer peptides were generated; of the two major HLA-B*51 subpeptidomes with Pro-2 and Ala-2, the former one was significantly reduced, and the latter was increased and showed more ERAP1-susceptible N-terminal residues.	Proline	124-127	endoplasmic reticulum aminopeptidase 1	Homo sapiens	21-26
28446606-6	2017	In the BD-associated ERAP1 context of B*51:08, longer peptides were generated; of the two major HLA-B*51 subpeptidomes with Pro-2 and Ala-2, the former one was significantly reduced, and the latter was increased and showed more ERAP1-susceptible N-terminal residues.	Proline	124-127	major histocompatibility complex, class I, B	Homo sapiens	96-101
28598414-2	2017	Here, we solve the structure of hRpn13 with a segment of hRpn2 that serves as its proteasome docking site; a proline-rich C-terminal hRpn2 extension stretches across a narrow canyon of the ubiquitin-binding hRpn13 Pru domain blocking an RA190-binding surface.	Proline	109-116	ribophorin II	Homo sapiens	133-138
28314105-1	2017	U24 is a C-terminal membrane-anchored protein found in both human herpes virus type 6 and 7 (HHV-6 and HHV-7), with an N-terminal segment that is rich in prolines (PPxY motif in both HHV-6A and 7; PxxP motif in HHV-6A).	Proline	154-162	small nucleolar RNA, C/D box 24	Homo sapiens	0-3
28135249-5	2017	We found that CdGAP used its proline-rich domain to form a functional complex with Zeb2 to mediate the repression of E-cadherin expression in ErbB2-transformed breast cancer cells.	Proline	29-36	Rho GTPase activating protein 31	Homo sapiens	14-19
28135249-5	2017	We found that CdGAP used its proline-rich domain to form a functional complex with Zeb2 to mediate the repression of E-cadherin expression in ErbB2-transformed breast cancer cells.	Proline	29-36	zinc finger E-box binding homeobox 2	Homo sapiens	83-87
28135249-5	2017	We found that CdGAP used its proline-rich domain to form a functional complex with Zeb2 to mediate the repression of E-cadherin expression in ErbB2-transformed breast cancer cells.	Proline	29-36	cadherin 1	Homo sapiens	117-127
28135249-5	2017	We found that CdGAP used its proline-rich domain to form a functional complex with Zeb2 to mediate the repression of E-cadherin expression in ErbB2-transformed breast cancer cells.	Proline	29-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	142-147
28604763-2	2017	PRH/HHEX (proline-rich homeodomain/haematopoietically expressed homeobox) is a transcription factor that displays both tumour suppressor and oncogenic activity in different disease contexts; however, the role of PRH in breast cancer is poorly understood.	Proline	10-17	hematopoietically expressed homeobox	Homo sapiens	0-3
28604763-2	2017	PRH/HHEX (proline-rich homeodomain/haematopoietically expressed homeobox) is a transcription factor that displays both tumour suppressor and oncogenic activity in different disease contexts; however, the role of PRH in breast cancer is poorly understood.	Proline	10-17	hematopoietically expressed homeobox	Homo sapiens	4-8
28604763-2	2017	PRH/HHEX (proline-rich homeodomain/haematopoietically expressed homeobox) is a transcription factor that displays both tumour suppressor and oncogenic activity in different disease contexts; however, the role of PRH in breast cancer is poorly understood.	Proline	10-17	hematopoietically expressed homeobox	Homo sapiens	212-215
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	248-255	cytochrome P450, family 11, subfamily C, polypeptide 1	Danio rerio	28-35
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	248-255	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	Danio rerio	37-46
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	248-255	cytochrome P450, family 17, subfamily A, polypeptide 1	Danio rerio	55-62
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	248-255	cytochrome P450, family 19, subfamily A, polypeptide 1a	Danio rerio	77-83
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	248-255	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	89-95
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	248-255	hypoxia inducible factor 1 subunit alpha a	Danio rerio	168-179
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	248-255	hypoxia inducible factor 1 subunit alpha a	Danio rerio	169-179
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	264-271	cytochrome P450, family 11, subfamily C, polypeptide 1	Danio rerio	28-35
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	264-271	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	Danio rerio	37-46
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	264-271	cytochrome P450, family 17, subfamily A, polypeptide 1	Danio rerio	55-62
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	264-271	cytochrome P450, family 19, subfamily A, polypeptide 1a	Danio rerio	77-83
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	264-271	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	89-95
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	264-271	hypoxia inducible factor 1 subunit alpha a	Danio rerio	168-179
28634424-4	2017	Eight of the genes, CYP11a, CYP11b2, 3beta-HSD, HMGCR, CYP17a1, 17beta-HSD2, CYP19a, and CYP19b, were found to be differentially upregulated at 24 and 48 hpf following zHIF-1alpha-DeltaODD overexpression (a mutant zebrafish HIF-1alpha protein with proline-414 and proline-557 deleted).	Proline	264-271	hypoxia inducible factor 1 subunit alpha a	Danio rerio	169-179
28322731-0	2017	The substitution of Proline 168 favors Bax oligomerization and stimulates its interaction with LUVs and mitochondria.	Proline	20-27	BCL2 associated X, apoptosis regulator	Homo sapiens	39-42
28570711-9	2017	CONCLUSION: Mutating position 718 in human IR-B to the proline found at position 718 in human IR-A increased IGF1 and IGF2 affinity to a level comparable to IR-A and mutating position 718 in IR-A to the lysine found at position 718 in IR-B decreased IGF1 and IGF2 affinity to a level comparable to IR-B, whereas a negatively charged glutamate did not.	Proline	55-62	insulin like growth factor 1	Homo sapiens	109-113
27503084-1	2017	Prolyl oligopeptidase (also named prolyl endopeptidase; PREP) hydrolyzes the Pro-Xaa bonds of biologically active oligopeptides on their carboxyl side.	Proline	0-3	prolyl endopeptidase	Homo sapiens	56-60
28452351-0	2017	Motor neuron disease: Detection of glycine-proline repeat protein offers new biomarker in patients with C9orf72 expansion.	Proline	43-50	C9orf72-SMCR8 complex subunit	Homo sapiens	104-111
28483057-3	2017	Physiological assays revealed that concentrations of osmolytes (proline and soluble sugars) and the activity of superoxide dismutase were significantly decreased in the lcbk1-2 mutant, compared with wild type.	Proline	64-71	long-chain base (LCB) kinase 1	Arabidopsis thaliana	169-176
28570711-9	2017	CONCLUSION: Mutating position 718 in human IR-B to the proline found at position 718 in human IR-A increased IGF1 and IGF2 affinity to a level comparable to IR-A and mutating position 718 in IR-A to the lysine found at position 718 in IR-B decreased IGF1 and IGF2 affinity to a level comparable to IR-B, whereas a negatively charged glutamate did not.	Proline	55-62	insulin like growth factor 2	Homo sapiens	118-122
28570711-9	2017	CONCLUSION: Mutating position 718 in human IR-B to the proline found at position 718 in human IR-A increased IGF1 and IGF2 affinity to a level comparable to IR-A and mutating position 718 in IR-A to the lysine found at position 718 in IR-B decreased IGF1 and IGF2 affinity to a level comparable to IR-B, whereas a negatively charged glutamate did not.	Proline	55-62	insulin like growth factor 1	Homo sapiens	250-254
28570711-9	2017	CONCLUSION: Mutating position 718 in human IR-B to the proline found at position 718 in human IR-A increased IGF1 and IGF2 affinity to a level comparable to IR-A and mutating position 718 in IR-A to the lysine found at position 718 in IR-B decreased IGF1 and IGF2 affinity to a level comparable to IR-B, whereas a negatively charged glutamate did not.	Proline	55-62	insulin like growth factor 2	Homo sapiens	259-263
28457793-2	2017	Here we demonstrate that Ngn3 protein undergoes cyclin-dependent kinase (Cdk)-mediated phosphorylation on multiple serine-proline sites.	Proline	122-129	neurogenin 3	Homo sapiens	25-29
28368102-5	2017	We observed that the interaction between a proline-rich motif in NS1 and the N-terminal SH3 domain of CrkII displays strikingly rapid kinetics and exceptionally high affinity with 100-fold faster kon and 3300-fold lower Kd compared to those for the CrkII-JNK1 interaction.	Proline	43-50	influenza virus NS1A binding protein	Homo sapiens	65-68
28368102-5	2017	We observed that the interaction between a proline-rich motif in NS1 and the N-terminal SH3 domain of CrkII displays strikingly rapid kinetics and exceptionally high affinity with 100-fold faster kon and 3300-fold lower Kd compared to those for the CrkII-JNK1 interaction.	Proline	43-50	CRK proto-oncogene, adaptor protein	Homo sapiens	102-107
28368102-5	2017	We observed that the interaction between a proline-rich motif in NS1 and the N-terminal SH3 domain of CrkII displays strikingly rapid kinetics and exceptionally high affinity with 100-fold faster kon and 3300-fold lower Kd compared to those for the CrkII-JNK1 interaction.	Proline	43-50	CRK proto-oncogene, adaptor protein	Homo sapiens	249-254
28368102-5	2017	We observed that the interaction between a proline-rich motif in NS1 and the N-terminal SH3 domain of CrkII displays strikingly rapid kinetics and exceptionally high affinity with 100-fold faster kon and 3300-fold lower Kd compared to those for the CrkII-JNK1 interaction.	Proline	43-50	mitogen-activated protein kinase 8	Homo sapiens	255-259
28373278-11	2017	TAS2R38 polymorphisms encode functional (PAV: proline, alanine, and valine at positions 49, 262, and 296, respectively) or non-functional (AVI: alanine, valine, isoleucine at positions 49, 262, and 296, respectively) T2R38.	Proline	46-53	taste 2 receptor member 38	Homo sapiens	0-7
28487390-5	2017	METHODS AND RESULTS: Consistent with its ability to inhibit prolyl-tRNA synthetase, halofuginone elicited a general control nonderepressible 2-dependent activation of the AAR pathway in cardiac fibroblasts as evidenced by activation of known AAR target genes, broad regulation of the transcriptome and proteome, and reversal by l-proline supplementation.	Proline	328-337	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	108-142
28587687-7	2017	Additionally, proline is oxidized by proline oxidase to yield pyrroline-5-carboxylate, which undergoes transamination with glutamate to produce ornithine for decarboxylation by ODC1.	Proline	14-21	ornithine decarboxylase 1	Homo sapiens	177-181
28477416-5	2017	With the protocol we were able to predict those high-affinity domain binders of the proline-rich peptides of human securin in a high-throughput manner, and to analyze sequence-specific interaction in the domain-peptide recognition at molecular level.	Proline	84-91	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	115-122
28292929-5	2017	Using in vitro binding assays, we find that RNF11 can directly compete with SMAD7 for SMURF2 and that binding is mutually exclusive and dependent on a proline-rich domain.	Proline	151-158	ring finger protein 11	Homo sapiens	44-49
28214592-4	2017	We found that the polymorphism rs1042522:C &gt; G in codon 72 of exon 4 of the TP53 gene, whose C variant produces a proline and is more common in most ethnicities, has a G variant producing an arginine in 79.8% of NFPAs (n = 42; p &lt; 1.411 x 10-18 vs. 1000 Genomes database), causing patients to present a decade earlier with symptomatic NFPAs.	Proline	117-124	tumor protein p53	Homo sapiens	79-83
28379297-1	2017	Human mitochondrial pyrroline-5-carboxylate reductase (PYCR) is a house-keeping enzyme that catalyzes the reduction of Delta1-pyrroline-5-carboxylate to proline.	Proline	153-160	pyrroline-5-carboxylate reductase 1	Homo sapiens	20-53
28492237-5	2017	We discover that proline catabolism via proline dehydrogenase (Prodh) supports growth of breast cancer cells in 3D culture.	Proline	17-24	proline dehydrogenase 1	Homo sapiens	40-61
28492237-5	2017	We discover that proline catabolism via proline dehydrogenase (Prodh) supports growth of breast cancer cells in 3D culture.	Proline	17-24	proline dehydrogenase 1	Homo sapiens	63-68
28341999-7	2017	Two such antibodies, CBTAU-7.1 and CBTAU-22.1, which bind to the proline-rich and C-terminal regions of tau, respectively, were characterized in more detail.	Proline	65-72	microtubule associated protein tau	Homo sapiens	104-107
28083596-1	2017	Cytochrome P450 2U1 (CYP2U1) exhibits several distinctive characteristics among the 57 human CYPs, such as its presence in almost all living organisms with a highly conserved sequence, its particular gene organization with only five exons, its major location in thymus and brain, and its protein sequence involving an unusually long N-terminal region containing 8 proline residues and an insert of about 20 amino acids containing 5 arginine residues after the transmembrane helix.	Proline	364-371	cytochrome P450 family 2 subfamily U member 1	Homo sapiens	0-19
28083596-1	2017	Cytochrome P450 2U1 (CYP2U1) exhibits several distinctive characteristics among the 57 human CYPs, such as its presence in almost all living organisms with a highly conserved sequence, its particular gene organization with only five exons, its major location in thymus and brain, and its protein sequence involving an unusually long N-terminal region containing 8 proline residues and an insert of about 20 amino acids containing 5 arginine residues after the transmembrane helix.	Proline	364-371	cytochrome P450 family 2 subfamily U member 1	Homo sapiens	21-27
28379297-1	2017	Human mitochondrial pyrroline-5-carboxylate reductase (PYCR) is a house-keeping enzyme that catalyzes the reduction of Delta1-pyrroline-5-carboxylate to proline.	Proline	153-160	pyrroline-5-carboxylate reductase 1	Homo sapiens	55-59
28294542-1	2017	AIMS: The proline-rich Akt substrate of 40-kDa (PRAS40) protein is a direct inhibitor of mTORC1 and an interactive linker between the Akt and mTOR pathways.	Proline	10-17	CREB regulated transcription coactivator 1	Mus musculus	89-95
28294542-1	2017	AIMS: The proline-rich Akt substrate of 40-kDa (PRAS40) protein is a direct inhibitor of mTORC1 and an interactive linker between the Akt and mTOR pathways.	Proline	10-17	mechanistic target of rapamycin kinase	Homo sapiens	89-93
28341660-6	2017	RNA pull-down, RNA immunoprecipitation (RIP), in vitro binding assays, and gain- and loss-of-function studies indicated that a physical interaction between linc-ADAMTS5 and splicing factor proline/glutamine-rich (SFPQ) facilitated the recruitment of RREB1 to binding sites within the ADAMTS5 promoter to induce chromatin remodeling.	Proline	189-196	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	161-168
27665014-3	2017	Both mucin sources are dominated by repetitive O-glycosylated areas dependant on threonine, serine, glycine, and proline.	Proline	113-120	LOC100508689	Homo sapiens	5-10
28406644-10	2017	In pure MeCN, [2a]PF6 and [3a]PF6 showed non-selective photosubstitution of both the l-proline and dmbpy ligands, whereas the non-strained complex [1a]PF6 was photostable.	Proline	85-94	sperm associated antigen 17	Homo sapiens	18-21
28406644-10	2017	In pure MeCN, [2a]PF6 and [3a]PF6 showed non-selective photosubstitution of both the l-proline and dmbpy ligands, whereas the non-strained complex [1a]PF6 was photostable.	Proline	85-94	sperm associated antigen 17	Homo sapiens	30-33
28406644-10	2017	In pure MeCN, [2a]PF6 and [3a]PF6 showed non-selective photosubstitution of both the l-proline and dmbpy ligands, whereas the non-strained complex [1a]PF6 was photostable.	Proline	85-94	sperm associated antigen 17	Homo sapiens	30-33
28406644-11	2017	Finally, in H2O-MeCN mixtures, [3a]PF6 showed selective photosubstitution of l-proline, thus demonstrating the active role played by the solvent on the photoreactivity of this series of complexes.	Proline	77-86	sperm associated antigen 17	Homo sapiens	35-38
28342111-6	2017	The increased stomatal aperture, leaf water loss and proline accumulation were observed in ckb1 mutants.	Proline	53-60	casein kinase II beta chain 1	Arabidopsis thaliana	91-95
28039930-8	2017	AtRBP45b protein has a N-terminal proline-rich region and a C-terminal glutamine-rich domain that are usually involved in protein-protein interactions.	Proline	34-41	RNA-binding (RRM/RBD/RNP motifs) family protein	Arabidopsis thaliana	0-8
28109651-9	2017	A hypothesis linked to the proline in the mutant GALC may explain the in vitro effect with high residual GALC activity.	Proline	27-34	galactosylceramidase	Homo sapiens	49-53
28109651-9	2017	A hypothesis linked to the proline in the mutant GALC may explain the in vitro effect with high residual GALC activity.	Proline	27-34	galactosylceramidase	Homo sapiens	105-109
28406644-3	2017	The synthesis of the tris-heteroleptic complex bearing the dissymmetric proline ligand yielded only two of the four possible regioisomers, called [2a]PF6 and [2b]PF6.	Proline	72-79	sperm associated antigen 17	Homo sapiens	150-153
28406644-3	2017	The synthesis of the tris-heteroleptic complex bearing the dissymmetric proline ligand yielded only two of the four possible regioisomers, called [2a]PF6 and [2b]PF6.	Proline	72-79	sperm associated antigen 17	Homo sapiens	162-165
28529593-7	2017	However, among the HER2-negative patients (n=2,442), those with the Pro/Ala or Ala/Ala genotype had a significantly decreased RFS [unadjusted hazard ratio (HR), 1.45; 95% confidence interval (CI), 1.03-2.04; P=0.033] and DRFS (unadjusted HR, 1.65; 95% CI, 1.11-2.44; P=0.012) compared with those with the Pro/Pro genotype.	Proline	68-71	erb-b2 receptor tyrosine kinase 2	Homo sapiens	19-23
28529593-8	2017	Multivariate analysis revealed that the Pro/Ala or Ala/Ala genotype was an independent unfavorable factor for DRFS (adjusted HR, 1.63; 95% CI, 1.05-2.53; P=0.029) in the subgroup of HER2-negative patients.	Proline	40-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	182-186
30364217-8	2017	Mass spectrometry provided results supporting that proline 45 (a well-conserved residue within the catalytic sequence) of the peroxiredoxin 6 molecule may be converted into glutamic acid in cultured human cells, opening up a revolutionizing concept that biological oxidation elicits the naturally occurring protein engineering process.	Proline	51-58	peroxiredoxin 6	Homo sapiens	126-141
28258219-0	2017	Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1.	Proline	43-50	pyrroline-5-carboxylate reductase 1	Homo sapiens	77-112
28258219-1	2017	Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline.	Proline	64-71	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-33
28258219-1	2017	Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline.	Proline	64-71	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-39
28258219-1	2017	Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline.	Proline	64-71	pyrroline-5-carboxylate reductase 1	Homo sapiens	138-162
28258219-1	2017	Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline.	Proline	64-71	pyrroline-5-carboxylate reductase 1	Homo sapiens	164-167
28258219-1	2017	Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline.	Proline	172-179	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-33
28258219-1	2017	Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline.	Proline	172-179	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-39
28258219-1	2017	Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline.	Proline	172-179	pyrroline-5-carboxylate reductase 1	Homo sapiens	138-162
28258219-1	2017	Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline.	Proline	172-179	pyrroline-5-carboxylate reductase 1	Homo sapiens	164-167
28258219-6	2017	Structures of binary complexes of PYCR1 with NADPH or proline determined at 1.9 A resolution provide insight into cofactor and substrate recognition.	Proline	54-61	pyrroline-5-carboxylate reductase 1	Homo sapiens	34-39
28258219-8	2017	The 1.85 A resolution structure of a ternary complex containing NADPH and a P5C/proline analog provides a model of the Michaelis complex formed during hydride transfer.	Proline	80-87	pyrroline-5-carboxylate reductase 1	Homo sapiens	76-79
28044345-6	2017	Consistently, metabolite profiling disclosed that the total amount of some protective metabolites including gamma-aminobutyric acid, proline, glutamine and sucrose were higher in CDF3-overexpressing plants.	Proline	133-140	cycling DOF factor 3	Arabidopsis thaliana	179-183
28392174-1	2017	The eukaryotic translation factor eIF5A, originally identified as an initiation factor, was later shown to promote translation elongation of iterated proline sequences.	Proline	150-157	eukaryotic translation initiation factor 5A	Homo sapiens	34-39
28455498-5	2017	The C-terminal SH3 domain (SH3C) of Grb2 bivalently interacts with the atypical non-PxxP proline rich region of SLP65, and the N-terminal SH3 domain (SH3N) of Vav, both the interactions crucial for the proper functioning of the B cell.	Proline	89-96	growth factor receptor bound protein 2	Homo sapiens	36-40
28315663-7	2017	We propose that local structural changes induced by the serine-to-proline substitution are responsible for the gain of catalytic activity of A3C.S61P.	Proline	66-73	apolipoprotein B mRNA editing enzyme catalytic subunit 3C	Homo sapiens	141-145
28392174-3	2017	Ribosome profiling of an eIF5A-depleted strain reveals a global elongation defect, with abundant ribosomes stalling at many sequences, not limited to proline stretches.	Proline	150-157	eukaryotic translation initiation factor 5A	Homo sapiens	25-30
28406454-6	2017	The binding affinity of 3 for PKCdelta, which is involved in growth inhibition and apoptosis, was several times lower than those of 1 and 2, possibly due to the absence of the hydrogen bond and CH/pi interaction between its side chain and either Met-239 or Pro-241 in the PKCdelta-C1B domain.	Proline	257-260	protein kinase C delta	Homo sapiens	30-38
28426725-1	2017	The prolyl isomerase Pin1 plays a key role in the modulation of proline-directed phosphorylation signaling by inducing local conformational changes in phosphorylated protein substrates.	Proline	64-71	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Danio rerio	21-25
28235806-0	2017	Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.	Proline	79-86	itchy E3 ubiquitin protein ligase	Homo sapiens	123-127
28235806-4	2017	In addition to these WW domains, Itch possesses a proline-rich region (PRR) that has been shown to interact with several Src homology 3 (SH3) domain-containing proteins.	Proline	50-57	itchy E3 ubiquitin protein ligase	Homo sapiens	33-37
28512575-1	2017	Multiple possibilities for the coordination of fac-[Re(CO)3(H2O)3]+ to a protein have been determined and include binding to Asp, Glu, Arg and His amino-acid residues as well as to the C-terminal carboxylate in the vicinity of Leu and Pro.	Proline	235-238	FA complementation group C	Homo sapiens	47-50
28348210-0	2017	Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.	Proline	29-36	myosin IE	Mus musculus	0-9
28348210-0	2017	Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.	Proline	29-36	PTK2 protein tyrosine kinase 2	Mus musculus	25-28
28348210-0	2017	Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.	Proline	29-36	fibronectin 1	Mus musculus	61-72
27981415-6	2017	An inhibitor for NHE3 exposure on the mucosal side completely abolished proline- and leucine-enhanced calcium transport, but not transepithelial transport of both amino acids themselves.	Proline	72-79	solute carrier family 9 member A3	Rattus norvegicus	17-21
28280121-3	2017	The C-terminal, proline-rich domains of TANGO1 molecules in the ring are initially tilted onto COPII coats but appear to be pushed apart as the carrier grows.	Proline	16-23	MIA SH3 domain ER export factor 3	Homo sapiens	40-46
28378780-3	2017	The conversion is catalyzed by angiotensin-converting enzyme 2 and other enzymes that selectively cleave the peptide bond between the proline and the phenylalanine at the carboxyl terminus of Ang II.	Proline	134-141	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	31-62
28378780-3	2017	The conversion is catalyzed by angiotensin-converting enzyme 2 and other enzymes that selectively cleave the peptide bond between the proline and the phenylalanine at the carboxyl terminus of Ang II.	Proline	134-141	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	192-198
28378780-6	2017	Here, we report a fluorometric method to measure carboxypeptidase activities that cleave the proline-phenylalanine dipeptide bond in Ang II.	Proline	93-100	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	133-139
28323963-3	2017	To study HCS, we created a mouse model harboring a point 6955C&gt;T mutation in the Notch2 locus upstream of the proline, glutamic acid, serine, and threonine domain, leading to a Q2319X change at the amino acid level.	Proline	113-120	notch 2	Mus musculus	84-90
28104445-12	2017	Our results suggest that the SH3 domain of human Caskin1 is a lipid-binding domain rather than a proline-rich motif interacting domain.	Proline	97-104	CASK interacting protein 1	Homo sapiens	49-56
28236106-9	2017	Progesterone treatment dephosphorylated both HSP90alpha and HSP90beta at Ser/Thr-Pro residues, but not Tyr residues.	Proline	0-3	heat shock protein 90 alpha family class A member 1	Homo sapiens	45-55
28212834-1	2017	Death-associated protein 1 (DAP1) is a small proline-rich cytoplasmic protein that functions both in the apoptosis and autophage process of mammalian and in the clinical cancer of human.	Proline	45-52	death associated protein	Homo sapiens	0-26
28212834-1	2017	Death-associated protein 1 (DAP1) is a small proline-rich cytoplasmic protein that functions both in the apoptosis and autophage process of mammalian and in the clinical cancer of human.	Proline	45-52	death associated protein	Homo sapiens	28-32
28236106-9	2017	Progesterone treatment dephosphorylated both HSP90alpha and HSP90beta at Ser/Thr-Pro residues, but not Tyr residues.	Proline	0-3	heat shock protein 90 alpha family class B member 1	Homo sapiens	60-69
27895165-3	2017	We describe here the generation of an Atm missense mutant [amino acid change of leucine (L) to proline (P) at position 2262 (L2262P)] rat by intracytoplasmic injection (ICSI) of mutant sperm into oocytes.	Proline	95-102	ATM serine/threonine kinase	Rattus norvegicus	38-41
28155114-8	2017	qRT-PCR analysis showed that over-expression of SlJA2 could down-regulate genes involved in reactive oxygen species scavenging, proline biosynthesis, and response to heat stress.	Proline	128-135	jasmonic acid 2	Solanum lycopersicum	48-53
26791972-6	2017	Stimulation of abscisic acid and jasmonate (JA) biosynthesis and accumulation of important compatible solutes, such as sugars, polyols and proline, as well as TCA cycle intermediates were observed in atpao5 mutants under salt stress.	Proline	139-146	polyamine oxidase 5	Arabidopsis thaliana	200-206
28329677-3	2017	Here, we show that, in turn, PHD2 triggers degradation of B55alpha by hydroxylating it at proline 319.	Proline	90-97	egl-9 family hypoxia inducible factor 1	Homo sapiens	29-33
28329677-3	2017	Here, we show that, in turn, PHD2 triggers degradation of B55alpha by hydroxylating it at proline 319.	Proline	90-97	protein phosphatase 2 regulatory subunit Balpha	Homo sapiens	58-66
28096188-4	2017	Here we show that Gab2 becomes phosphorylated on multiple proline-directed sites upon stimulation of the Ras/extracellular signal-regulated kinase (ERK) signaling pathway.	Proline	58-65	GRB2 associated binding protein 2	Homo sapiens	18-22
28087737-7	2017	In silico analysis showed that proline at codon position 508 is highly conserved in 26 vertebrate species, and the mutation is predicted to affect the conformation of the B30.2/SPRY domain of TRIM36.	Proline	31-38	tripartite motif containing 36	Homo sapiens	192-198
28096188-4	2017	Here we show that Gab2 becomes phosphorylated on multiple proline-directed sites upon stimulation of the Ras/extracellular signal-regulated kinase (ERK) signaling pathway.	Proline	58-65	mitogen-activated protein kinase 3	Homo sapiens	148-151
28132911-1	2017	Leukotriene A4 hydrolase is a soluble enzyme with epoxide hydrolase and aminopeptidase activities catalysing the conversion of leukotriene A4 to leukotriene B4 and the hydrolysis of the peptide proline-glycine-proline.	Proline	194-201	leukotriene A4 hydrolase	Homo sapiens	0-24
28132911-1	2017	Leukotriene A4 hydrolase is a soluble enzyme with epoxide hydrolase and aminopeptidase activities catalysing the conversion of leukotriene A4 to leukotriene B4 and the hydrolysis of the peptide proline-glycine-proline.	Proline	210-217	leukotriene A4 hydrolase	Homo sapiens	0-24
28270554-6	2017	We extended the number of putative Hog1 direct targets by analyzing the modulation of motifs consisting of serine or threonine followed by a proline (S/T-P motif) and subsequently validated these with an in vivo interaction assay.	Proline	141-148	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	35-39
28326087-5	2017	Overexpression of AtJUB1 in tomato delays fruit ripening, which is accompanied by reduced expression of several ripening-related genes, and leads to an increase in the levels of various amino acids (mostly proline, beta-alanine, and phenylalanine), gamma-aminobutyric acid (GABA), and major organic acids including glutamic acid and aspartic acid.	Proline	206-213	NAC domain containing protein 42	Arabidopsis thaliana	18-24
27491550-8	2017	Collectively, our results indicate that ZmPEPC gene can enhance photochemical and antioxidant enzyme activity, upregulate the expression of photosynthesis-related genes, delay degradation of chlorophyll, change contents of proline and other metabolites in wheat, and ultimately improves its heat tolerance.	Proline	223-230	phosphoenolpyruvate carboxylase 1	Zea mays	40-46
28262728-2	2017	A central common signaling mechanism in cancer is proline-directed phosphorylation, which is further regulated by the unique proline isomerase Pin1.	Proline	50-57	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	143-147
28257692-5	2017	Primary cells revealed one substitution severely impaired OGFOD1-dependent hydroxylation of a neighboring proline residue resulting in 40S ribosomal subunits that were blocked from polysome formation.	Proline	106-113	2-oxoglutarate and iron dependent oxygenase domain containing 1	Homo sapiens	58-64
28057762-7	2017	We found that the minimal domains required for efficient Ede1 localization at CME sites are the third EH domain, the proline-rich region, and the coiled-coil region.	Proline	117-124	Ede1p	Saccharomyces cerevisiae S288C	57-61
28184937-1	2017	The Pin1 protein (or peptidyl-prolyl cis/trans isomerase) specifically catalyzes the cis/trans isomerization of phosphorylated serine/threonine-proline (Ser/Thr-Pro) bonds and plays an important role in many cellular events through the effects of conformational change in the function of c-Jun, its biological substrate.	Proline	144-151	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	4-8
28184937-1	2017	The Pin1 protein (or peptidyl-prolyl cis/trans isomerase) specifically catalyzes the cis/trans isomerization of phosphorylated serine/threonine-proline (Ser/Thr-Pro) bonds and plays an important role in many cellular events through the effects of conformational change in the function of c-Jun, its biological substrate.	Proline	144-151	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	288-293
28184937-1	2017	The Pin1 protein (or peptidyl-prolyl cis/trans isomerase) specifically catalyzes the cis/trans isomerization of phosphorylated serine/threonine-proline (Ser/Thr-Pro) bonds and plays an important role in many cellular events through the effects of conformational change in the function of c-Jun, its biological substrate.	Proline	161-164	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	4-8
28184937-1	2017	The Pin1 protein (or peptidyl-prolyl cis/trans isomerase) specifically catalyzes the cis/trans isomerization of phosphorylated serine/threonine-proline (Ser/Thr-Pro) bonds and plays an important role in many cellular events through the effects of conformational change in the function of c-Jun, its biological substrate.	Proline	161-164	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	288-293
27975189-1	2017	KEY MESSAGE: ANAC069 binds to the DNA sequence of C[A/G]CG[T/G] to regulate the expression of genes, resulting in decreased ROS scavenging capability and proline biosynthesis, which contribute to increased sensitivity to salt and osmotic stress.	Proline	154-161	NAC domain containing protein 69	Arabidopsis thaliana	13-20
27975189-7	2017	Consequently, the transcript level of ANAC069 correlated negatively with the reactive oxygen species (ROS) scavenging ability and the proline level.	Proline	134-141	NAC domain containing protein 69	Arabidopsis thaliana	38-45
27975189-10	2017	Collectively, our data suggest that ANAC069 could recognize C[A/G]CG[T/G] sequences to regulate the expression of genes that negatively regulates salt and osmotic stress tolerance by decreasing ROS scavenging capability and proline biosynthesis.	Proline	224-231	NAC domain containing protein 69	Arabidopsis thaliana	36-43
27965114-2	2017	Grb2 is an adaptor protein whose central SH2 domain binds to phosphorylated tyrosine residues of activated receptors and activates intracellular signaling pathway, while its N-terminal and C-terminal SH3 domains bind to proline rich proteins such as N-WASP (Neural-Wiskott Aldrich Syndrome Protein).	Proline	220-227	growth factor receptor bound protein 2	Mus musculus	0-4
28054303-8	2017	We propose that these four prolines and four lysines in a Kv1.4 homotetramer might provide a binding site for a putative endoplasmic reticulum-export molecule to ensure high cell surface protein expression of the channel.	Proline	27-35	potassium voltage-gated channel subfamily A member 4	Homo sapiens	58-63
27680505-3	2017	The BCNP1 protein contains a pleckstrin homology (PH) domain, two proline-rich (PR) regions and a Leucine Zipper (LZ) domain suggesting that it may be involved in protein-protein interactions.	Proline	66-73	niban apoptosis regulator 3	Rattus norvegicus	4-9
28369480-0	2017	PCA22 acts as a suppressor of atrzf1 to mediate proline accumulation in response to abiotic stress in Arabidopsis.	Proline	48-55	RING/U-box superfamily protein	Arabidopsis thaliana	30-36
28369480-5	2017	Using the atrzf1 (Arabidopsis thaliana ring zinc finger 1) mutant as a parental line for activation tagging mutagenesis, we selected several mutants with suppressed induction of proline accumulation under dehydration conditions.	Proline	178-185	RING/U-box superfamily protein	Arabidopsis thaliana	10-16
28184937-4	2017	Since phosphorylation of proteins on Ser/Thr-Pro is a key regulatory mechanism in the control of cell proliferation and transformation, Pin1 has become an attractive molecule in cancer research.	Proline	45-48	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	136-140
28158298-5	2017	CH-3 contains a tripeptide (methionine-lysine-proline, MKP) that has been found to have a strong ACE inhibitory effect and the potential to pass through the BBB.	Proline	46-53	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	97-100
28069952-1	2017	The toxic proline:arginine (PRn) poly-dipeptide encoded by the (GGGGCC)n repeat expansion in the C9orf72 form of heritable amyotrophic lateral sclerosis (ALS) binds to the central channel of the nuclear pore and inhibits the movement of macromolecules into and out of the nucleus.	Proline	10-17	C9orf72-SMCR8 complex subunit	Homo sapiens	97-104
28225038-3	2017	The interaction is mediated by the proline rich domain of MEK1/2 and regulated by phosphorylation of Ser298 in MEK1, or Ser306 in MEK2, which we identified here as a novel regulatory site.	Proline	35-42	mitogen-activated protein kinase kinase 1	Mus musculus	58-64
28225038-3	2017	The interaction is mediated by the proline rich domain of MEK1/2 and regulated by phosphorylation of Ser298 in MEK1, or Ser306 in MEK2, which we identified here as a novel regulatory site.	Proline	35-42	mitogen-activated protein kinase kinase 1	Mus musculus	58-62
28225038-3	2017	The interaction is mediated by the proline rich domain of MEK1/2 and regulated by phosphorylation of Ser298 in MEK1, or Ser306 in MEK2, which we identified here as a novel regulatory site.	Proline	35-42	mitogen-activated protein kinase kinase 2	Mus musculus	130-134
28352338-6	2017	Left ventricular ejection fraction in the early PCI group markedly increased and left ventricular end-diastolic diameter and pro-BNP level decreased significantly.	Proline	125-128	natriuretic peptide B	Homo sapiens	129-132
27860360-1	2017	Pyrroline-5-carboxylate reductase 2, encoded by PYCR2, is one of the three homologous enzymes that catalyze the last step of proline synthesis.	Proline	125-132	pyrroline-5-carboxylate reductase 2	Homo sapiens	0-35
27860360-1	2017	Pyrroline-5-carboxylate reductase 2, encoded by PYCR2, is one of the three homologous enzymes that catalyze the last step of proline synthesis.	Proline	125-132	pyrroline-5-carboxylate reductase 2	Homo sapiens	48-53
28041831-1	2017	As a follow-up to the discovery of our spirocyclic proline-based TPH1 inhibitor lead, we describe the optimization of this scaffold.	Proline	51-58	tryptophan hydroxylase 1	Rattus norvegicus	65-69
28357076-5	2017	The distribution frequency of p53 sites of arginine (Arg)/Arg, Arg/proline (Pro), Pro/Pro were 18.4, 48.8 and 32.8% in the control group, as compared with 18.7, 49.9 and 31.4% in the case group, which indicated that there was no difference between two groups (chi2=0.14; P=0.93).	Proline	67-74	tumor protein p53	Homo sapiens	30-33
27834957-2	2017	PIN1 exerts its action by inducing conformational and functional changes on key cellular proteins, following proline-directed phosphorylation.	Proline	109-116	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
27995772-9	2017	SlSIZ1 overexpression conferred the plants with improved growth, high free proline content, minimal malondialdehyde accumulation and increased accumulation of SUMO conjugates.	Proline	75-82	E3 SUMO-protein ligase SIZ1	Solanum lycopersicum	0-6
27862082-13	2017	All three isolates, NRT2, TRC3, and THB3 showed lower accumulation of malondialdehyde (MDA) content whereas, proline and phenol content were higher than the uninoculated control plants under both normal and saline conditions.	Proline	109-116	nitrate transport 2	Zea mays	20-24
27919567-0	2017	Splicing factor proline/glutamine-rich is a novel autoantigen of dermatomyositis and associated with anti-melanoma differentiation-associated gene 5 antibody.	Proline	16-23	SLU7 homolog, splicing factor	Homo sapiens	0-15
27470091-1	2017	Synaptopodin (SP) is a proline-rich actin-associated protein essential for the formation of a spine apparatus (SA) in dendritic spines.	Proline	23-30	synaptopodin	Mus musculus	0-12
27345930-5	2017	We first determined the structure of both natively membrane anchored MLV Env and MLV Env tagged with YFP in the proline rich region (PRR) by electron cryo tomography (cET) and sub-volume averaging.	Proline	112-119	endogenous retrovirus group K member 20	Homo sapiens	85-88
27470091-1	2017	Synaptopodin (SP) is a proline-rich actin-associated protein essential for the formation of a spine apparatus (SA) in dendritic spines.	Proline	23-30	synaptopodin	Mus musculus	14-16
27939882-10	2017	Pyrroline-5-carboxylate reductase (Pycr1), an enzyme involved in proline biosynthesis, had higher basal levels in FVB/N male and female mouse pancreata compared with BALB/c pancreata, and was relatively more resistant to degradation in FVB/N pancreata.	Proline	65-72	pyrroline-5-carboxylate reductase 1	Mus musculus	35-40
27787902-10	2017	ERF1 was degraded by the 26S proteasome system via regulation of UBC18 and promotes dark-repression of downstream genes and proline accumulation.	Proline	124-131	eukaryotic translation termination factor 1	Homo sapiens	0-4
27896837-2	2017	Several interaction partners for the TSAd proline-rich region and phosphotyrosines have been identified, including the Src and Tec family kinases lymphocyte-specific protein tyrosine kinase and interleukin 2-inducible T cell kinase.	Proline	42-49	SH2 domain containing 2A	Mus musculus	37-41
27896837-2	2017	Several interaction partners for the TSAd proline-rich region and phosphotyrosines have been identified, including the Src and Tec family kinases lymphocyte-specific protein tyrosine kinase and interleukin 2-inducible T cell kinase.	Proline	42-49	Rous sarcoma oncogene	Mus musculus	119-122
27997792-1	2017	Oligosaccharyltransferase (OST) transfers an oligosaccharide chain to the Asn residue in the Asn-X-Ser/Thr sequon in proteins, where X is not proline.	Proline	142-149	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	0-25
27997792-1	2017	Oligosaccharyltransferase (OST) transfers an oligosaccharide chain to the Asn residue in the Asn-X-Ser/Thr sequon in proteins, where X is not proline.	Proline	142-149	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	27-30
28126757-3	2017	Gid4 recognized the N-terminal proline (Pro) residue and the ~5-residue-long adjacent sequence motifs.	Proline	31-38	glucose-induced degradation complex subunit VID24	Saccharomyces cerevisiae S288C	0-4
28126757-3	2017	Gid4 recognized the N-terminal proline (Pro) residue and the ~5-residue-long adjacent sequence motifs.	Proline	40-43	glucose-induced degradation complex subunit VID24	Saccharomyces cerevisiae S288C	0-4
28126757-4	2017	Pck1, the fourth gluconeogenic enzyme, contains Pro at position 2; Gid4 directly or indirectly recognized Pro at position 2 of Pck1, contributing to its targeting.	Proline	48-51	phosphoenolpyruvate carboxykinase PCK1	Saccharomyces cerevisiae S288C	0-4
28126757-4	2017	Pck1, the fourth gluconeogenic enzyme, contains Pro at position 2; Gid4 directly or indirectly recognized Pro at position 2 of Pck1, contributing to its targeting.	Proline	106-109	phosphoenolpyruvate carboxykinase PCK1	Saccharomyces cerevisiae S288C	0-4
28126757-4	2017	Pck1, the fourth gluconeogenic enzyme, contains Pro at position 2; Gid4 directly or indirectly recognized Pro at position 2 of Pck1, contributing to its targeting.	Proline	106-109	glucose-induced degradation complex subunit VID24	Saccharomyces cerevisiae S288C	67-71
28126757-4	2017	Pck1, the fourth gluconeogenic enzyme, contains Pro at position 2; Gid4 directly or indirectly recognized Pro at position 2 of Pck1, contributing to its targeting.	Proline	106-109	phosphoenolpyruvate carboxykinase PCK1	Saccharomyces cerevisiae S288C	127-131
27870570-7	2017	Results NOTCH1 mutations occurred predominantly (14 of 15 patients) in the negative regulatory region and Pro-Glu-Ser-Thr-rich domains, the same two hotspots seen in T-cell acute lymphoblastic leukemias, and led to pathway activation in vitro.	Proline	106-109	notch receptor 1	Homo sapiens	8-14
28134934-1	2017	PRH/HHEX (proline-rich homeodomain protein/haematopoietically expressed homeobox protein) is a transcription factor that controls cell proliferation, cell differentiation and cell migration.	Proline	10-17	hematopoietically expressed homeobox	Homo sapiens	0-3
28134934-1	2017	PRH/HHEX (proline-rich homeodomain protein/haematopoietically expressed homeobox protein) is a transcription factor that controls cell proliferation, cell differentiation and cell migration.	Proline	10-17	hematopoietically expressed homeobox	Homo sapiens	4-8
27881676-0	2017	Cytoplasmic Localization of Proline, Glutamic Acid, Leucine-rich Protein 1 (PELP1) Induces Breast Epithelial Cell Migration through Up-regulation of Inhibitor of kappaB Kinase epsilon and Inflammatory Cross-talk with Macrophages.	Proline	28-35	proline, glutamate and leucine rich protein 1	Homo sapiens	76-81
27503676-6	2017	Moreover, HLA-B*07-bound peptides preferentially harbored dimethylated groups at the P3 position, thus consecutively to the proline anchor residue.	Proline	124-131	major histocompatibility complex, class I, B	Homo sapiens	10-15
27503676-7	2017	Such a proline-arginine sequence has been associated with the arginine methyl-transferases CARM1 and PRMT5.	Proline	7-14	coactivator associated arginine methyltransferase 1	Homo sapiens	91-96
27503676-7	2017	Such a proline-arginine sequence has been associated with the arginine methyl-transferases CARM1 and PRMT5.	Proline	7-14	protein arginine methyltransferase 5	Homo sapiens	101-106
27827825-0	2017	Controlled stem cell amplification by HOXB4 depends on its unique proline-rich region near the N terminus.	Proline	66-73	homeobox B4	Mus musculus	38-43
27827825-3	2017	Here we show in mice that this characteristic of HOXB4 depends on a proline-rich sequence near the N terminus, which is unique among HOX genes and highly conserved in higher mammals.	Proline	68-75	homeobox B4	Mus musculus	49-54
28573254-3	2017	RESULTS: The presence of proline at the C-terminal tripeptide of ACE inhibitor can competitively inhibit the ACE activity.	Proline	25-32	angiotensin I converting enzyme	Homo sapiens	65-68
28573254-3	2017	RESULTS: The presence of proline at the C-terminal tripeptide of ACE inhibitor can competitively inhibit the ACE activity.	Proline	25-32	angiotensin I converting enzyme	Homo sapiens	109-112
28003464-5	2017	In contrast, compared with eIF4G1, NAT1 preferentially interacted with eIF2, fragile X mental retardation proteins (FMR), and related proteins and especially with members of the proline-rich and coiled-coil-containing protein 2 (PRRC2) family.	Proline	178-185	eukaryotic translation initiation factor 4, gamma 2	Mus musculus	35-39
27881676-0	2017	Cytoplasmic Localization of Proline, Glutamic Acid, Leucine-rich Protein 1 (PELP1) Induces Breast Epithelial Cell Migration through Up-regulation of Inhibitor of kappaB Kinase epsilon and Inflammatory Cross-talk with Macrophages.	Proline	28-35	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	149-183
27881676-1	2017	Cytoplasmic localization of proline, glutamic acid, leucine-rich protein 1 (PELP1) is observed in ~40% of women with invasive breast cancer.	Proline	28-35	proline, glutamate and leucine rich protein 1	Homo sapiens	76-81
28051106-1	2017	U24 is a protein found in both roseoloviruses Human Herpes Virus type 6 and 7 (HHV-6 and HHV-7), with an N-terminus that is rich in prolines (PY motif in both HHV-6A and 7; PxxP motif in HHV-6A).	Proline	132-140	small nucleolar RNA, C/D box 24	Homo sapiens	0-3
28446944-3	2017	To facilitate the treatment of this disease, we aimed to investigate proline-rich peptide (PRP-1) action of hypothalamus on hippocampal (HP) neurons and dynamics of their recovery, after intracerebroventricular (ICV) injection of amyloid-beta (Abeta).	Proline	69-76	tumor-associated calcium signal transducer 2	Rattus norvegicus	91-96
28049762-8	2017	However, Src did not directly bind to recombinant TBK1 in vitro but instead bound to the proline-X-X-proline motifs within key PRR adaptor proteins, such as TRIF, MAVS, and STING, which formed complexes with TBK1 after PRR engagement.	Proline	89-96	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	9-12
28049762-8	2017	However, Src did not directly bind to recombinant TBK1 in vitro but instead bound to the proline-X-X-proline motifs within key PRR adaptor proteins, such as TRIF, MAVS, and STING, which formed complexes with TBK1 after PRR engagement.	Proline	89-96	nuclear receptor subfamily 1 group I member 2	Homo sapiens	127-130
28942439-0	2017	Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX-Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model.	Proline	41-48	proline dehydrogenase 1	Homo sapiens	79-84
27756573-5	2017	The cochaperone utilizes its WW domain to contact a proline-rich motif in the tuberous sclerosis protein TSC1 that functions as an mTORC1 inhibitor in association with TSC2.	Proline	52-59	TSC complex subunit 1	Homo sapiens	105-109
27756573-5	2017	The cochaperone utilizes its WW domain to contact a proline-rich motif in the tuberous sclerosis protein TSC1 that functions as an mTORC1 inhibitor in association with TSC2.	Proline	52-59	CREB regulated transcription coactivator 1	Mus musculus	131-137
27756573-5	2017	The cochaperone utilizes its WW domain to contact a proline-rich motif in the tuberous sclerosis protein TSC1 that functions as an mTORC1 inhibitor in association with TSC2.	Proline	52-59	TSC complex subunit 2	Homo sapiens	168-172
27768124-5	2017	The human Tp53 gene harbors a common single-nucleotide polymorphism (SNP) at codon 72, which yields an arginine-to-proline amino-acidic substitution (Arg72Pro) that modulates the apoptotic activity of the p53 protein.	Proline	115-122	tumor protein p53	Homo sapiens	10-14
27768124-5	2017	The human Tp53 gene harbors a common single-nucleotide polymorphism (SNP) at codon 72, which yields an arginine-to-proline amino-acidic substitution (Arg72Pro) that modulates the apoptotic activity of the p53 protein.	Proline	115-122	tumor protein p53	Homo sapiens	11-14
27769935-0	2017	The matrikine N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells via CXCR1-dependent ROS accumulation and DNA damage and reinforces the destructive effect of these cells on homeostasis of intervertebral discs.	Proline	27-34	C-X-C motif chemokine receptor 1	Rattus norvegicus	110-115
27769935-0	2017	The matrikine N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells via CXCR1-dependent ROS accumulation and DNA damage and reinforces the destructive effect of these cells on homeostasis of intervertebral discs.	Proline	43-50	C-X-C motif chemokine receptor 1	Rattus norvegicus	110-115
28674258-9	2017	Inhibition of PHD-mediated hydroxylation of a proline residue within the N-terminal ankyrin repeat of hTRPA1 endows TRPA1 with cold sensitivity by its sensing of cold-evoked ROS.	Proline	46-53	transient receptor potential cation channel subfamily A member 1	Homo sapiens	102-108
28674258-9	2017	Inhibition of PHD-mediated hydroxylation of a proline residue within the N-terminal ankyrin repeat of hTRPA1 endows TRPA1 with cold sensitivity by its sensing of cold-evoked ROS.	Proline	46-53	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	103-108
28194412-1	2017	Pyrroline-5-carboxylate reductase (P5CR1) is a universal housekeeping enzyme that catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)+.	Proline	149-156	pyrroline-5-carboxylate reductase 1	Homo sapiens	115-139
28194412-1	2017	Pyrroline-5-carboxylate reductase (P5CR1) is a universal housekeeping enzyme that catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)+.	Proline	149-156	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-38
28194412-2	2017	The enzymatic cycle between P5C and proline is important for function in amino acid metabolism, apoptosis, and intracellular redox potential balance in mitochondria.	Proline	36-43	pyrroline-5-carboxylate reductase 1	Homo sapiens	28-31
28942439-9	2017	RESULTS: PRODH/POX knockdown decreased DNA and collagen biosynthesis, whereas increased prolidase activity and intracellular proline level in MCF-7shPRODH/POX cells.	Proline	125-132	proline dehydrogenase 1	Homo sapiens	155-158
28942439-12	2017	All the compounds inhibited collagen biosynthesis, increased prolidase activity and cytoplasmic proline level in MCF-7shPRODH/POX cells and contributed to the induction of pro-survival mode only in MCF-7shPRODH/POX cells.	Proline	96-103	proline dehydrogenase 1	Homo sapiens	126-129
28942439-14	2017	CONCLUSION: PRODH/POX was confirmed as a driver of apoptosis and proved the eligibility of MCF-7shPRODH/POX cell line as a highly effective model to elucidate the different mechanisms underlying proline utilization or generation in PRODH/POX-dependent pro-apoptotic pathways.	Proline	195-202	proline dehydrogenase 1	Homo sapiens	12-17
28942439-0	2017	Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX-Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model.	Proline	41-48	proline dehydrogenase 1	Homo sapiens	85-88
28942439-1	2017	BACKGROUND/AIMS: The effect of impaired intracellular proline availability for proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied.	Proline	54-61	proline dehydrogenase 1	Homo sapiens	118-127
28942439-14	2017	CONCLUSION: PRODH/POX was confirmed as a driver of apoptosis and proved the eligibility of MCF-7shPRODH/POX cell line as a highly effective model to elucidate the different mechanisms underlying proline utilization or generation in PRODH/POX-dependent pro-apoptotic pathways.	Proline	195-202	proline dehydrogenase 1	Homo sapiens	18-21
28942439-14	2017	CONCLUSION: PRODH/POX was confirmed as a driver of apoptosis and proved the eligibility of MCF-7shPRODH/POX cell line as a highly effective model to elucidate the different mechanisms underlying proline utilization or generation in PRODH/POX-dependent pro-apoptotic pathways.	Proline	195-202	proline dehydrogenase 1	Homo sapiens	98-103
28942439-3	2017	We have used inhibitor of proline utilization in collagen biosynthesis, 2-metoxyestradiol (MOE), inhibitor of prolidase that generate proline, rapamycin (Rap) and glycyl-proline (GlyPro), substrate for prolidase.	Proline	26-33	peptidase D	Homo sapiens	202-211
28942439-3	2017	We have used inhibitor of proline utilization in collagen biosynthesis, 2-metoxyestradiol (MOE), inhibitor of prolidase that generate proline, rapamycin (Rap) and glycyl-proline (GlyPro), substrate for prolidase.	Proline	134-141	peptidase D	Homo sapiens	110-119
28942439-9	2017	RESULTS: PRODH/POX knockdown decreased DNA and collagen biosynthesis, whereas increased prolidase activity and intracellular proline level in MCF-7shPRODH/POX cells.	Proline	125-132	proline dehydrogenase 1	Homo sapiens	9-14
28942439-9	2017	RESULTS: PRODH/POX knockdown decreased DNA and collagen biosynthesis, whereas increased prolidase activity and intracellular proline level in MCF-7shPRODH/POX cells.	Proline	125-132	proline dehydrogenase 1	Homo sapiens	15-18
27912083-9	2017	Accordingly, in this condition, gene expression of Delta1-6 Pyrroline-5-Carboxylate Synthetase1 (P5CS1) involved in proline synthesis strongly increased in wild type but not in ahr1 seedlings.	Proline	116-123	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	97-102
29375644-7	2017	Furthermore, metabolomics analysis showed that TGP treatment significantly attenuated CCl4-triggered deregulation of multiple metabolites in both urine and serum, including glycine, alanine, proline, and glutamine.	Proline	191-198	C-C motif chemokine ligand 4	Rattus norvegicus	86-90
27879050-2	2017	PRMT2 is a modular protein containing a catalytic Ado-Met-binding domain and unique Src homology 3 domain that binds proteins with proline-rich motifs.	Proline	131-138	protein arginine N-methyltransferase 2	Mus musculus	0-5
29333597-2	2017	TP53 codon 72 polymorphism (P72R) results in proline (P) or arginine (R) at 72 amino acid position, which causes synthesis of proteins with distinct functions.	Proline	45-52	tumor protein p53	Homo sapiens	0-4
28638407-0	2017	The Proline 7 Substitution in the Preproneuropeptide Y Is Associated with Higher Hepatic Lipase Activity In Vivo.	Proline	4-11	lipase C, hepatic type	Homo sapiens	81-95
29465378-6	2017	Amino acid analysis of HAPA-elastin showed a high content (81.5%) of hydrophobic amino acids such as Gly, Ala, Val, and Pro.	Proline	120-123	LOC100620140	Sus scrofa	28-35
28211815-0	2017	Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.	Proline	134-141	huntingtin	Mus musculus	80-90
28211815-1	2017	BACKGROUND: The polyglutamine (polyQ) stretch of the Huntingtin protein (HTT) in mammals is flanked by a highly conserved 17 amino acid N-terminal domain (N17), and a proline-rich region (PRR).	Proline	167-174	huntingtin	Mus musculus	53-63
28211815-1	2017	BACKGROUND: The polyglutamine (polyQ) stretch of the Huntingtin protein (HTT) in mammals is flanked by a highly conserved 17 amino acid N-terminal domain (N17), and a proline-rich region (PRR).	Proline	167-174	huntingtin	Mus musculus	73-76
27902963-2	2017	Under normoxic conditions, a conserved proline in HIF2alpha is hydroxylated by PHD2 in an oxygen-dependent manner, and then pVHL binds and promotes the degradation of HIF2alpha.	Proline	39-46	endothelial PAS domain protein 1	Homo sapiens	50-59
27902963-2	2017	Under normoxic conditions, a conserved proline in HIF2alpha is hydroxylated by PHD2 in an oxygen-dependent manner, and then pVHL binds and promotes the degradation of HIF2alpha.	Proline	39-46	egl-9 family hypoxia inducible factor 1	Homo sapiens	79-83
27902963-2	2017	Under normoxic conditions, a conserved proline in HIF2alpha is hydroxylated by PHD2 in an oxygen-dependent manner, and then pVHL binds and promotes the degradation of HIF2alpha.	Proline	39-46	von Hippel-Lindau tumor suppressor	Homo sapiens	124-128
27902963-2	2017	Under normoxic conditions, a conserved proline in HIF2alpha is hydroxylated by PHD2 in an oxygen-dependent manner, and then pVHL binds and promotes the degradation of HIF2alpha.	Proline	39-46	endothelial PAS domain protein 1	Homo sapiens	167-176
26965690-2	2017	Mutations within FBXO7 have been found to cause an early-onset Parkinson"s disease, and these are found within or near to its functional domains, including its F-box domain (FBD), its proline rich region (PRR), and its ubiquitinlike domain (Ubl).	Proline	184-191	F-box protein 7	Homo sapiens	17-22
28769017-4	2017	Proline hydroxylation by O2-dependent hydroxylases also regulates the O2-sensing function by inhibiting TRPA1 in normoxia; TRPA1 is activated by hypoxia through relief from the inhibition and by hyperoxia through cysteine oxidation that overrides the inhibition.	Proline	0-7	transient receptor potential cation channel subfamily A member 1	Homo sapiens	104-109
27067078-1	2017	The enzyme prolidase cleaves dipeptides where the C-terminal amino acid corresponds to proline or hydroxyproline.	Proline	87-94	peptidase D	Homo sapiens	11-20
27939849-10	2017	A PEST (rich in Pro, Glu/Asp, Ser, and Thr) sequence-dependent endoplasmic reticulum-associated protein degradation (ERAD) mechanism was established to decrease cellular levels of Erg9p without relying on inducers, repressors or specific repressing conditions.	Proline	16-19	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	180-185
27687004-5	2017	These mutations target critical functional domains (PR motif, proline rich domain, acidic region, and DNA-binding Zn-finger domain) involved in the regulation of different targets such as MYC.	Proline	62-69	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	188-191
28769017-4	2017	Proline hydroxylation by O2-dependent hydroxylases also regulates the O2-sensing function by inhibiting TRPA1 in normoxia; TRPA1 is activated by hypoxia through relief from the inhibition and by hyperoxia through cysteine oxidation that overrides the inhibition.	Proline	0-7	transient receptor potential cation channel subfamily A member 1	Homo sapiens	123-128
28003549-2	2016	Antigen binding to the T cell receptor (TCR) triggers the recruitment of the cytosolic adaptor protein Nck to a proline-rich sequence in the cytoplasmic tail of the TCR"s CD3epsilon subunit.	Proline	112-119	NCK adaptor protein 1	Homo sapiens	103-106
27916453-6	2016	SHANK3 interacts with transient receptor potential subtype V1 (TRPV1) via Proline-rich region and regulates TRPV1 surface expression.	Proline	74-81	SH3 and multiple ankyrin repeat domains 3	Mus musculus	0-6
27916453-6	2016	SHANK3 interacts with transient receptor potential subtype V1 (TRPV1) via Proline-rich region and regulates TRPV1 surface expression.	Proline	74-81	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	22-61
27916453-6	2016	SHANK3 interacts with transient receptor potential subtype V1 (TRPV1) via Proline-rich region and regulates TRPV1 surface expression.	Proline	74-81	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	63-68
27863418-1	2016	PIN1, which belongs to a family of prolyl isomerases, specifically binds to phosphorylated Ser/Thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates.	Proline	35-38	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
27974198-5	2016	Mechanistically, proline catabolism governs reactive oxygen species (ROS) homeostasis and subsequent activation of SKN-1, a critical transcription factor regulating xenobiotic stress response and pathogen defense.	Proline	17-24	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	115-120
27930298-5	2016	Primary salt stress induced the expression of Delta1-pyrroline-5-carboxylate synthetase 1 (P5CS1), encoding a proline biosynthetic enzyme and proline accumulation, which were reduced to basal level during the recovery stage.	Proline	110-117	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	52-89
27930298-5	2016	Primary salt stress induced the expression of Delta1-pyrroline-5-carboxylate synthetase 1 (P5CS1), encoding a proline biosynthetic enzyme and proline accumulation, which were reduced to basal level during the recovery stage.	Proline	110-117	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	91-96
27930298-5	2016	Primary salt stress induced the expression of Delta1-pyrroline-5-carboxylate synthetase 1 (P5CS1), encoding a proline biosynthetic enzyme and proline accumulation, which were reduced to basal level during the recovery stage.	Proline	142-149	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	52-89
27930298-5	2016	Primary salt stress induced the expression of Delta1-pyrroline-5-carboxylate synthetase 1 (P5CS1), encoding a proline biosynthetic enzyme and proline accumulation, which were reduced to basal level during the recovery stage.	Proline	142-149	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	91-96
27977750-8	2016	Gain- and Loss-of-function studies of ZFP3 showed that ZFP3 significantly changes proline accumulation and chlorophyll content.	Proline	82-89	zinc finger protein 3	Arabidopsis thaliana	38-42
27977750-8	2016	Gain- and Loss-of-function studies of ZFP3 showed that ZFP3 significantly changes proline accumulation and chlorophyll content.	Proline	82-89	zinc finger protein 3	Arabidopsis thaliana	55-59
27974198-6	2016	Intriguingly, proline catabolism-mediated activation of SKN-1 requires cell-membrane dual-oxidase Ce-Duox1/BLI-3, highlighting the importance of interaction between mitochondrial and cell-membrane components in host defense.	Proline	14-21	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	56-61
27974198-6	2016	Intriguingly, proline catabolism-mediated activation of SKN-1 requires cell-membrane dual-oxidase Ce-Duox1/BLI-3, highlighting the importance of interaction between mitochondrial and cell-membrane components in host defense.	Proline	14-21	dual oxidase 1	Homo sapiens	101-106
27927196-2	2016	LITAF encodes a 17 kDa protein containing an N-terminal proline-rich region followed by an evolutionarily-conserved C-terminal "LITAF domain", which contains all reported CMT1C-associated pathogenic mutations.	Proline	56-63	lipopolysaccharide induced TNF factor	Homo sapiens	0-5
27929538-2	2016	Here we identify the ankyrin-repeat-containing, SH3-domain-containing, and proline-rich region-containing protein 2 (ASPP2), a haploinsufficient tumor suppressor, as a molecular regulator of starvation-induced autophagy in hepatocellular carcinoma (HCC).	Proline	75-82	tumor protein p53 binding protein 2	Homo sapiens	117-122
28018099-1	2016	PIN1 is a peptidyl-prolyl cis/trans isomerase that binds and catalyses isomerization of the specific motif comprising a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) in proteins.	Proline	175-182	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
28018099-1	2016	PIN1 is a peptidyl-prolyl cis/trans isomerase that binds and catalyses isomerization of the specific motif comprising a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) in proteins.	Proline	193-196	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
28018099-2	2016	PIN1 can therefore induce conformational and functional changes of its interacting proteins that are regulated by proline-directed serine/threonine phosphorylation.	Proline	114-121	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
27756840-7	2016	Additionally, the S121P/S121P PGHS-2 variants in which Pro-127 and Ser-541 are replaced by cysteines spontaneously forms Cys-127 to Cys-541 cross-links between monomers.	Proline	55-58	prostaglandin-endoperoxide synthase 2	Homo sapiens	30-36
27672730-6	2016	Two of them carried novel mutations in the PRO1 gene encoding the Pro247Ser or Glu415Lys variant of gamma-glutamyl kinase (GK), which is a key enzyme in proline biosynthesis in S. cerevisiae.	Proline	153-160	glutamate 5-kinase	Saccharomyces cerevisiae S288C	43-47
27693394-1	2016	Previously, we reported that microinjection of L-proline (L-Pro) into the paraventricular nucleus of the hypothalamus (PVN) caused vasopressin-mediated pressor responses in unanesthetized rats.	Proline	47-56	arginine vasopressin	Rattus norvegicus	131-142
27572155-4	2016	Since Pin1 is overexpressed and/or activated in various types of cancers, and the dysregulation of proline-directed phosphorylation contributes to tumorigenesis, Pin1 represents an attractive target for cancer therapy.	Proline	99-106	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	162-166
28033105-6	2016	Multivariate analysis showed a significant association with NSCLC for the combination between the TP53 codon72 Arg/Pro and the Pro/Pro genotypes (OR 2.21, 95 % CI 1.390-3.51; p=0.001).	Proline	115-118	tumor protein p53	Homo sapiens	98-102
27693394-1	2016	Previously, we reported that microinjection of L-proline (L-Pro) into the paraventricular nucleus of the hypothalamus (PVN) caused vasopressin-mediated pressor responses in unanesthetized rats.	Proline	58-63	arginine vasopressin	Rattus norvegicus	131-142
27693394-8	2016	In conclusion, the results suggest that ionotropic receptors in the PVN, blocked by both NMDA and non-NMDA receptor antagonists, mediate the pressor response to L-Pro that results from activation of PVN vasopressinergic magnocellular neurons and vasopressin release into the systemic circulation.	Proline	161-166	arginine vasopressin	Rattus norvegicus	203-214
27905398-4	2016	We identify a proline-rich segment of ZCCHC8 as the interaction site for the RNA-recognition motif (RRM) of RBM7 and present the crystal structure of the corresponding complex at 2.0 A resolution.	Proline	14-21	zinc finger CCHC-type containing 8	Homo sapiens	38-44
27665170-3	2016	The triple proline amylinomimetic compound (25,28,29-Pro-human amylin) named pramlintide was designed aiming to solve the solubility and amyloid characteristics of human amylin.	Proline	11-18	islet amyloid polypeptide	Homo sapiens	19-25
27665170-3	2016	The triple proline amylinomimetic compound (25,28,29-Pro-human amylin) named pramlintide was designed aiming to solve the solubility and amyloid characteristics of human amylin.	Proline	11-18	islet amyloid polypeptide	Homo sapiens	63-69
27790836-9	2016	These studies provide novel insights regarding the complexity of interactions between Pin1 and activated IRAK1, and more broadly suggest that phosphorylation of neighboring Ser/Thr-Pro motifs in proteins might provide competitive advantage at cellular concentrations for engaging with Pin1.	Proline	181-184	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	86-90
27790836-9	2016	These studies provide novel insights regarding the complexity of interactions between Pin1 and activated IRAK1, and more broadly suggest that phosphorylation of neighboring Ser/Thr-Pro motifs in proteins might provide competitive advantage at cellular concentrations for engaging with Pin1.	Proline	181-184	interleukin 1 receptor associated kinase 1	Homo sapiens	105-110
27790836-9	2016	These studies provide novel insights regarding the complexity of interactions between Pin1 and activated IRAK1, and more broadly suggest that phosphorylation of neighboring Ser/Thr-Pro motifs in proteins might provide competitive advantage at cellular concentrations for engaging with Pin1.	Proline	181-184	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	285-289
27667567-8	2016	ELF3 has previously been shown to regulate the expression of SPPR1A and SPRR1B, small proline-rich proteins that contribute to the cornification of keratinocytes.	Proline	86-93	E74 like ETS transcription factor 3	Homo sapiens	0-4
27667567-8	2016	ELF3 has previously been shown to regulate the expression of SPPR1A and SPRR1B, small proline-rich proteins that contribute to the cornification of keratinocytes.	Proline	86-93	small proline rich protein 1B	Homo sapiens	72-78
27905398-4	2016	We identify a proline-rich segment of ZCCHC8 as the interaction site for the RNA-recognition motif (RRM) of RBM7 and present the crystal structure of the corresponding complex at 2.0 A resolution.	Proline	14-21	RNA binding motif protein 7	Homo sapiens	108-112
27905398-5	2016	On the basis of the structure, we identify a proline-rich segment within the splicing factor SAP145 with strong similarity to ZCCHC8.	Proline	45-52	splicing factor 3b subunit 2	Homo sapiens	93-99
27905398-5	2016	On the basis of the structure, we identify a proline-rich segment within the splicing factor SAP145 with strong similarity to ZCCHC8.	Proline	45-52	zinc finger CCHC-type containing 8	Homo sapiens	126-132
27814568-6	2016	Further studies showed that the proline contents in the transgenic plants are markedly decreased associated with reduced expression of the P5CS1 gene under both normal and stress conditions.	Proline	32-39	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	139-144
27596594-10	2016	As in wild-type Klf4 (E446), the proline at position 446 does not interact directly with either the 5mC N4 nitrogen or the thymine O4 oxygen.	Proline	33-40	Kruppel like factor 4	Homo sapiens	16-20
27771248-8	2016	Structure-function analysis using dynamin2 deletion fragments identified the proline/arginine-rich domain (PRD) of dynamin2 as indispensable for invadopodia formation and invasiveness of T24 cells.	Proline	77-84	dynamin 2	Homo sapiens	115-123
27807972-8	2016	We show that the conformational properties of Ash1 and pAsh1 can be explained in terms of the linear sequence patterning of proline and charged residues vis-a-vis all other residues.	Proline	124-131	DNA-binding transcription repressor ASH1	Saccharomyces cerevisiae S288C	46-50
27894420-4	2016	NMR and biochemical experiments demonstrate that the OCRE domain directly binds to the proline-rich C-terminal tail of the essential snRNP core proteins SmN/B/B".	Proline	87-94	small nuclear ribonucleoprotein polypeptide N	Homo sapiens	153-156
27750098-4	2016	Under Cd stress, CKB4ox showed reduced root growth and biomass accumulation as well as decreased chlorophyll and proline contents compared with wild type.	Proline	113-120	casein kinase II beta subunit 4	Arabidopsis thaliana	17-21
27764789-7	2016	Our study identified and validated Brd4, a key transcription factor, as a novel proline hydroxylation substrate.	Proline	80-87	bromodomain containing 4	Homo sapiens	35-39
27764789-8	2016	Functional analysis showed that the inhibition of proline hydroxylation pathway significantly reduced the proline hydroxylation abundance on Brd4 and affected Brd4-mediated transcriptional activity as well as cell proliferation in AML leukemia cells.	Proline	50-57	bromodomain containing 4	Homo sapiens	141-145
27764789-8	2016	Functional analysis showed that the inhibition of proline hydroxylation pathway significantly reduced the proline hydroxylation abundance on Brd4 and affected Brd4-mediated transcriptional activity as well as cell proliferation in AML leukemia cells.	Proline	50-57	bromodomain containing 4	Homo sapiens	159-163
27764789-8	2016	Functional analysis showed that the inhibition of proline hydroxylation pathway significantly reduced the proline hydroxylation abundance on Brd4 and affected Brd4-mediated transcriptional activity as well as cell proliferation in AML leukemia cells.	Proline	106-113	bromodomain containing 4	Homo sapiens	141-145
27019979-5	2016	Moreover, the flavonoid-induced AChE expression in cultured osteoblast was in proline-rich membrane anchor (PRiMA)-linked tetrameric globular form (G4) only.	Proline	78-85	acetylcholinesterase	Rattus norvegicus	32-36
27019979-5	2016	Moreover, the flavonoid-induced AChE expression in cultured osteoblast was in proline-rich membrane anchor (PRiMA)-linked tetrameric globular form (G4) only.	Proline	78-85	proline rich membrane anchor 1	Rattus norvegicus	108-113
27870861-1	2016	We report here interesting synergistic effects of proline and sorbitol, two well-known chemical chaperones, in the inhibition of fibrillation of two proteins, insulin and lysozyme.	Proline	50-57	insulin	Homo sapiens	159-166
27475846-1	2016	Pin1 is a peptidylprolyl cis/trans isomerase and it has a unique enzymatic activity of catalyzing isomerization of the peptide bond between phospho-serine/threonine and proline.	Proline	169-176	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
27857062-4	2016	PCO371 does not affect the PTH type 2 receptor (PTHR2), and analysis using PTHR1-PTHR2 chimeric receptors indicated that Proline 415 of PTHR1 is critical for PCO371-mediated PTHR1 activation.	Proline	121-128	parathyroid hormone	Rattus norvegicus	75-80
27857062-4	2016	PCO371 does not affect the PTH type 2 receptor (PTHR2), and analysis using PTHR1-PTHR2 chimeric receptors indicated that Proline 415 of PTHR1 is critical for PCO371-mediated PTHR1 activation.	Proline	121-128	parathyroid hormone 2 receptor	Rattus norvegicus	81-86
27857062-4	2016	PCO371 does not affect the PTH type 2 receptor (PTHR2), and analysis using PTHR1-PTHR2 chimeric receptors indicated that Proline 415 of PTHR1 is critical for PCO371-mediated PTHR1 activation.	Proline	121-128	parathyroid hormone	Rattus norvegicus	136-141
27857062-4	2016	PCO371 does not affect the PTH type 2 receptor (PTHR2), and analysis using PTHR1-PTHR2 chimeric receptors indicated that Proline 415 of PTHR1 is critical for PCO371-mediated PTHR1 activation.	Proline	121-128	parathyroid hormone	Rattus norvegicus	136-141
27736076-6	2016	We apply these methods to a family of short elastin-like peptides (ELPs), fragments of the elastin protein based around the Pro-Gly turn motif characteristic of the elastomeric segments of the full protein.	Proline	124-127	elastin	Homo sapiens	44-51
27736076-6	2016	We apply these methods to a family of short elastin-like peptides (ELPs), fragments of the elastin protein based around the Pro-Gly turn motif characteristic of the elastomeric segments of the full protein.	Proline	124-127	elastin	Homo sapiens	91-98
27812033-1	2016	A long-lived aldol reaction-based iridium(III) chemosensor [Ir(ppy)2(5-CHOphen)]PF6 (1, where ppy = 2-phenylpyridine and 5-CHOphen = 1,10-phenanthroline-5-carbaldehyde) for proline detection has been synthesized.	Proline	173-180	sperm associated antigen 17	Homo sapiens	80-83
27735004-0	2016	Structural essentials for beta-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids.	Proline	78-86	O-GlcNAcase	Homo sapiens	26-53
27667292-3	2016	The RUNX1 fusion transcript encodes a truncated protein containing the Runt homology domain responsible for both heterodimerization with CBFB and DNA binding, but lacking the proline-, serine-, and threonine-rich (PST) region which is the transcription activation domain at the C terminal end.	Proline	175-182	RUNX family transcription factor 1	Homo sapiens	4-9
27806266-0	2016	Kinetic Insights into the Binding between the nSH3 Domain of CrkII and Proline-Rich Motifs in cAbl.	Proline	71-78	CRK proto-oncogene, adaptor protein	Homo sapiens	61-66
27806266-0	2016	Kinetic Insights into the Binding between the nSH3 Domain of CrkII and Proline-Rich Motifs in cAbl.	Proline	71-78	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	94-98
27806266-2	2016	This interaction starts with the binding of the N-terminal Src homology 3 (nSH3) domain of CrkII to the proline-rich motifs of cAbl (PRMscAbl).	Proline	104-111	CRK proto-oncogene, adaptor protein	Homo sapiens	91-96
27806266-2	2016	This interaction starts with the binding of the N-terminal Src homology 3 (nSH3) domain of CrkII to the proline-rich motifs of cAbl (PRMscAbl).	Proline	104-111	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	127-131
27618686-0	2016	Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis.	Proline	0-7	CREB regulated transcription coactivator 1	Mus musculus	60-66
27618686-5	2016	Cancer cells exhibiting dependency on exogenous proline displayed hyperactivation of the mTORC1-mediated 4EBP1 signaling axis, as well as unresolved ER stress.	Proline	48-55	CREB regulated transcription coactivator 1	Mus musculus	89-95
27618686-5	2016	Cancer cells exhibiting dependency on exogenous proline displayed hyperactivation of the mTORC1-mediated 4EBP1 signaling axis, as well as unresolved ER stress.	Proline	48-55	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	105-110
27513819-4	2016	The G3BP-complex contained the deubiquitinating protease USP10, CtBP1 and the RNA-binding proteins Caprin-1, G3BP2a and splicing factor proline and glutamine rich, or PSF.	Proline	136-143	GTPase activating protein (SH3 domain) binding protein 1	Mus musculus	4-8
27648609-6	2016	Furthermore, peptide CT-2 (Leu-Gln-Pro-Ser-His-Tyr) potently inhibited melanogenesis in mouse B16 melanoma cells without causing cytotoxicity, suggesting the potential of CT-2 as an agent for melanin-related skin disorder treatment.	Proline	35-38	cardiotrophin 2	Mus musculus	21-25
27484974-1	2016	Dipeptidyl peptidase-4 (DPP-4), glycyl-prolyl-naphthylamidase, is a serine protease that catalyzes the hydrolysis of various proline-containing polypeptides.	Proline	125-132	dipeptidyl peptidase 4	Homo sapiens	0-22
27484974-1	2016	Dipeptidyl peptidase-4 (DPP-4), glycyl-prolyl-naphthylamidase, is a serine protease that catalyzes the hydrolysis of various proline-containing polypeptides.	Proline	125-132	dipeptidyl peptidase 4	Homo sapiens	24-29
29235833-5	2016	Molecular mass of lipoxygenase is 90 kDa, amino acid composition is distinguished by a high content of glutamic acid, proline, valine, isoleucine, leucine and low level of histidine, tyrosine, phenylalanine, threonine, tryptophan, cystein.	Proline	118-125	LOC543232	Triticum aestivum	18-30
27648609-6	2016	Furthermore, peptide CT-2 (Leu-Gln-Pro-Ser-His-Tyr) potently inhibited melanogenesis in mouse B16 melanoma cells without causing cytotoxicity, suggesting the potential of CT-2 as an agent for melanin-related skin disorder treatment.	Proline	35-38	cardiotrophin 2	Mus musculus	171-175
27605668-10	2016	The signaling does not require a functional SH2 domain or the tyrosine residues commonly phosphorylated in Shc1 but is mediated by the interaction between a short segment of the central domain of Shc1 and the proline-rich region of Pyk2.	Proline	209-216	SHC adaptor protein 1	Homo sapiens	107-111
27818670-9	2016	In addition, the proline biosynthesis genes, Delta 1-Pyrroline-5-Carboxylate Synthase 1 and 2 (P5CS1 and P5CS2) were up-regulated in HvPIP2;5 overexpressing plants under salt and osmotic stresses, which coincided with increased levels of the osmoprotectant proline.	Proline	17-24	PIP2;5	Hordeum vulgare	133-141
27605668-10	2016	The signaling does not require a functional SH2 domain or the tyrosine residues commonly phosphorylated in Shc1 but is mediated by the interaction between a short segment of the central domain of Shc1 and the proline-rich region of Pyk2.	Proline	209-216	SHC adaptor protein 1	Homo sapiens	196-200
27605668-10	2016	The signaling does not require a functional SH2 domain or the tyrosine residues commonly phosphorylated in Shc1 but is mediated by the interaction between a short segment of the central domain of Shc1 and the proline-rich region of Pyk2.	Proline	209-216	protein tyrosine kinase 2 beta	Homo sapiens	232-236
27818670-9	2016	In addition, the proline biosynthesis genes, Delta 1-Pyrroline-5-Carboxylate Synthase 1 and 2 (P5CS1 and P5CS2) were up-regulated in HvPIP2;5 overexpressing plants under salt and osmotic stresses, which coincided with increased levels of the osmoprotectant proline.	Proline	257-264	PIP2;5	Hordeum vulgare	133-141
27650557-7	2016	The increased passive tension was caused by hypophosphorylation of the titin N2-B unique sequence and hyperphosphorylation of the PEVK (titin domain rich in proline, glutamate, valine, and lysine) region of titin.	Proline	157-164	titin	Mus musculus	136-141
27041574-7	2016	Together with the in vivo data demonstrating a strong tumor-promoting activity of PRR14 and the mutants, our work uncovered this proline-rich protein as a novel activator of the PI3K pathway that promoted tumorigenesis in lung cancer.	Proline	129-136	proline rich 14	Homo sapiens	82-87
27650557-7	2016	The increased passive tension was caused by hypophosphorylation of the titin N2-B unique sequence and hyperphosphorylation of the PEVK (titin domain rich in proline, glutamate, valine, and lysine) region of titin.	Proline	157-164	titin	Mus musculus	136-141
27543005-10	2016	Conversely, we demonstrate that several amino acid substitutions (including His, Phe, Pro, Trp, and Tyr) support an enhanced viability during oxidative stress associated with oxidized Kar2, although these alleles are compromised as an ATPase.	Proline	86-89	Hsp70 family ATPase KAR2	Saccharomyces cerevisiae S288C	184-188
27180175-8	2016	The fact that the highest hydroxylation degrees of proline residues were found for elastin from the intervertebral disc and knowledge of elastin arrangement in this tissue suggest that hydroxylation plays a biomechanical role.	Proline	51-58	elastin	Homo sapiens	83-90
27515399-9	2016	The data also present a new proline isomerization assay for CypD by monitoring the aggregation of p53 as an indicator of CypD activity.	Proline	28-35	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	60-64
27515399-9	2016	The data also present a new proline isomerization assay for CypD by monitoring the aggregation of p53 as an indicator of CypD activity.	Proline	28-35	transformation related protein 53, pseudogene	Mus musculus	98-101
27515399-9	2016	The data also present a new proline isomerization assay for CypD by monitoring the aggregation of p53 as an indicator of CypD activity.	Proline	28-35	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	121-125
27618664-0	2016	Karyopherin-beta2 Recognition of a PY-NLS Variant that Lacks the Proline-Tyrosine Motif.	Proline	65-72	transportin 1	Homo sapiens	0-17
27618664-1	2016	Karyopherin-beta2 or Transportin-1 binds proline-tyrosine nuclear localization signals (PY-NLSs) in its cargos.	Proline	41-48	transportin 1	Homo sapiens	0-17
27618664-1	2016	Karyopherin-beta2 or Transportin-1 binds proline-tyrosine nuclear localization signals (PY-NLSs) in its cargos.	Proline	41-48	transportin 1	Homo sapiens	21-34
27723793-4	2016	EPL cells form from mES cells in response to l-proline uptake through the transporter Slc38a2.	Proline	45-54	solute carrier family 38, member 2	Mus musculus	86-93
27708211-4	2016	The EKLF factor consists of two domains: proline-rich transactivation domain and DNA-binding domain containing three zinc finger motifs, which recognize DNA.	Proline	41-48	Kruppel like factor 1	Homo sapiens	4-8
27705802-1	2016	Proline dehydrogenase (PRODH), which degrades L-proline, resides within the schizophrenia-linked 22q11.2 deletion suggesting a role in disease.	Proline	46-55	proline dehydrogenase	Mus musculus	0-21
27705802-1	2016	Proline dehydrogenase (PRODH), which degrades L-proline, resides within the schizophrenia-linked 22q11.2 deletion suggesting a role in disease.	Proline	46-55	proline dehydrogenase	Mus musculus	23-28
27705802-4	2016	Here, we show that Prodh-deficient mice with elevated CNS L-proline display specific deficits in high-frequency GABA-ergic transmission and gamma-band oscillations.	Proline	58-67	proline dehydrogenase	Mus musculus	19-24
27180175-9	2016	Interestingly, a proline-rich domain of tropoelastin (domain 24), which contains several repeats of bioactive motifs, does not show any hydroxyproline residues in the mammals studied.	Proline	17-24	elastin	Homo sapiens	40-52
27589827-4	2016	The results showed that acute administration of proline enhanced CAT, SOD and GSH-Px activities, as well as, TBARS in the cortex and decreased CAT activity in the medulla, while chronic treatment increased the activities of SOD in the cortex and increased CAT, SOD and GSH-Px in the medulla of rats.	Proline	48-55	glutathione peroxidase 1	Rattus norvegicus	78-84
27589827-4	2016	The results showed that acute administration of proline enhanced CAT, SOD and GSH-Px activities, as well as, TBARS in the cortex and decreased CAT activity in the medulla, while chronic treatment increased the activities of SOD in the cortex and increased CAT, SOD and GSH-Px in the medulla of rats.	Proline	48-55	glutathione peroxidase 1	Rattus norvegicus	269-275
27296112-7	2016	In silico analysis revealed that a new nNOS-specific GSP (glycine-serine-proline) motif was well-conserved across species at nNOS-Ser(293), which is located ahead of the N-terminal hook.	Proline	73-80	nitric oxide synthase 1, neuronal	Mus musculus	39-43
27598034-8	2016	Alternatively, 15d-PGJ2 was found to covalently bind to HIF-1alpha prolyl-4-hydroxylase 2 (PHD2) in MCF-7 cells, which hampers the proline hydroxylation of HIF-1alpha, thereby disrupting ubiquitin-dependent proteasomal degradation of this transcription factor.	Proline	131-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
27598034-8	2016	Alternatively, 15d-PGJ2 was found to covalently bind to HIF-1alpha prolyl-4-hydroxylase 2 (PHD2) in MCF-7 cells, which hampers the proline hydroxylation of HIF-1alpha, thereby disrupting ubiquitin-dependent proteasomal degradation of this transcription factor.	Proline	131-138	egl-9 family hypoxia inducible factor 1	Homo sapiens	91-95
27233083-0	2016	Proline isomerisation as a novel regulatory mechanism for p38MAPK activation and functions.	Proline	0-7	mitogen-activated protein kinase 14	Mus musculus	58-65
27722206-9	2016	Although amino acids in the antigenic regions on VP7 and VP4 were mostly identical to those of global G2P[4] strains after 2000, VP4 of clade D RVAs in 2013 had alanine and proline at positions 88 and 114, respectively, which are novel substitutions compared with recent global G2P[4] strains.	Proline	173-180	outer capsid spike protein VP4	Rotavirus A	129-132
26868487-6	2016	Immunoprecipitation with anti-ZEB1 antibodies followed by western analysis with a phospho-Threonine-Proline-specific antibody indicates that the ERK consensus site at Thr-867 is phosphorylated in ZEB1.	Proline	100-107	mitogen-activated protein kinase 1	Homo sapiens	145-148
26868487-6	2016	Immunoprecipitation with anti-ZEB1 antibodies followed by western analysis with a phospho-Threonine-Proline-specific antibody indicates that the ERK consensus site at Thr-867 is phosphorylated in ZEB1.	Proline	100-107	zinc finger E-box binding homeobox 1	Homo sapiens	196-200
27349859-1	2016	The proline-rich Akt (v-akt murine thymoma viral oncogene homolog 1) substrate of 40 kDa (PRAS40), an inhibitory component of the mTORC1 complex, was identified as an Akt substrate through phosphorylation at Thr246.	Proline	4-11	thymoma viral proto-oncogene 1	Mus musculus	17-20
27349859-1	2016	The proline-rich Akt (v-akt murine thymoma viral oncogene homolog 1) substrate of 40 kDa (PRAS40), an inhibitory component of the mTORC1 complex, was identified as an Akt substrate through phosphorylation at Thr246.	Proline	4-11	thymoma viral proto-oncogene 1	Mus musculus	24-27
27349859-1	2016	The proline-rich Akt (v-akt murine thymoma viral oncogene homolog 1) substrate of 40 kDa (PRAS40), an inhibitory component of the mTORC1 complex, was identified as an Akt substrate through phosphorylation at Thr246.	Proline	4-11	AKT1 substrate 1 (proline-rich)	Mus musculus	90-96
27349859-1	2016	The proline-rich Akt (v-akt murine thymoma viral oncogene homolog 1) substrate of 40 kDa (PRAS40), an inhibitory component of the mTORC1 complex, was identified as an Akt substrate through phosphorylation at Thr246.	Proline	4-11	CREB regulated transcription coactivator 1	Mus musculus	130-136
27349859-1	2016	The proline-rich Akt (v-akt murine thymoma viral oncogene homolog 1) substrate of 40 kDa (PRAS40), an inhibitory component of the mTORC1 complex, was identified as an Akt substrate through phosphorylation at Thr246.	Proline	4-11	thymoma viral proto-oncogene 1	Mus musculus	167-170
27296112-7	2016	In silico analysis revealed that a new nNOS-specific GSP (glycine-serine-proline) motif was well-conserved across species at nNOS-Ser(293), which is located ahead of the N-terminal hook.	Proline	73-80	nitric oxide synthase 1, neuronal	Mus musculus	125-129
27512016-3	2016	Two mutants having high PDH1pro:LUC2 expression and increased Pro accumulation at low water potential were found to be alleles of Cytochrome P450, Family 86, Subfamily A, Polypeptide2 (CYP86A2) and Long Chain Acyl Synthetase2 (LACS2), which catalyze two successive steps in very-long-chain fatty acid (VLCFA) synthesis.	Proline	62-65	cytochrome P450, family 86, subfamily A, polypeptide 2	Arabidopsis thaliana	130-156
27499097-1	2016	Phosphorylation of proteins on serine/threonine residues that precede proline (pSer/Thr-Pro) is specifically catalyzed by the peptidyl-prolyl cis-trans isomerase PIN1.	Proline	70-77	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	162-166
27512016-3	2016	Two mutants having high PDH1pro:LUC2 expression and increased Pro accumulation at low water potential were found to be alleles of Cytochrome P450, Family 86, Subfamily A, Polypeptide2 (CYP86A2) and Long Chain Acyl Synthetase2 (LACS2), which catalyze two successive steps in very-long-chain fatty acid (VLCFA) synthesis.	Proline	62-65	cytochrome P450, family 86, subfamily A, polypeptide 2	Arabidopsis thaliana	171-183
27512016-3	2016	Two mutants having high PDH1pro:LUC2 expression and increased Pro accumulation at low water potential were found to be alleles of Cytochrome P450, Family 86, Subfamily A, Polypeptide2 (CYP86A2) and Long Chain Acyl Synthetase2 (LACS2), which catalyze two successive steps in very-long-chain fatty acid (VLCFA) synthesis.	Proline	62-65	cytochrome P450, family 86, subfamily A, polypeptide 2	Arabidopsis thaliana	185-192
28357320-0	2016	Putative mitochondrial alpha-ketoglutarate-dependent dioxygenase Fmp12 controls utilization of proline as an energy source in Saccharomyces cerevisiae.	Proline	95-102	Aim17p	Saccharomyces cerevisiae S288C	65-70
27473084-3	2016	In this study, we report that downregulation of ASPP2, a member of the ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region-containing protein (ASPP) family, bestowed HCC cells with stem-like properties and resistance to chemotherapy, including the expansion of side population fractions, formation of hepatospheroids, expression of stem cell-associated genes, loss of chemosensitivity, and increased tumorigenicity in immunodeficient mice.	Proline	125-132	transformation related protein 53 binding protein 2	Mus musculus	48-53
27451391-14	2016	Interestingly, the C-terminal TIP150 proline-rich region (CT150) binds to the Src homology 3 domain of cortactin specifically, and such an interaction is negatively regulated by EGF-elicited tyrosine phosphorylation of cortactin.	Proline	37-44	microtubule associated scaffold protein 2	Homo sapiens	30-36
27451391-14	2016	Interestingly, the C-terminal TIP150 proline-rich region (CT150) binds to the Src homology 3 domain of cortactin specifically, and such an interaction is negatively regulated by EGF-elicited tyrosine phosphorylation of cortactin.	Proline	37-44	nuclear receptor subfamily 6 group A member 1	Homo sapiens	58-63
27451391-14	2016	Interestingly, the C-terminal TIP150 proline-rich region (CT150) binds to the Src homology 3 domain of cortactin specifically, and such an interaction is negatively regulated by EGF-elicited tyrosine phosphorylation of cortactin.	Proline	37-44	cortactin	Homo sapiens	103-112
27451391-14	2016	Interestingly, the C-terminal TIP150 proline-rich region (CT150) binds to the Src homology 3 domain of cortactin specifically, and such an interaction is negatively regulated by EGF-elicited tyrosine phosphorylation of cortactin.	Proline	37-44	cortactin	Homo sapiens	219-228
27657535-0	2016	Normal Development and Function of T Cells in Proline Rich 7 (Prr7) Deficient Mice.	Proline	46-53	proline rich 7 (synaptic)	Mus musculus	62-66
27641460-4	2016	An increase in the hydrophobicity of the residue preceding the proline and cyclization of the VPGF peptide strengthen its recognition by the FK1 domain of FKBP52.	Proline	63-70	FKBP prolyl isomerase 4	Homo sapiens	155-161
27652979-1	2016	Cyclophilins are peptidyl-prolyl cis/trans isomerases (PPIase) that catalyse the interconversion of the peptide bond at proline residues.	Proline	120-127	peptidylprolyl isomerase like 3	Homo sapiens	0-12
27652979-1	2016	Cyclophilins are peptidyl-prolyl cis/trans isomerases (PPIase) that catalyse the interconversion of the peptide bond at proline residues.	Proline	120-127	peptidylprolyl isomerase like 3	Homo sapiens	17-53
27652979-1	2016	Cyclophilins are peptidyl-prolyl cis/trans isomerases (PPIase) that catalyse the interconversion of the peptide bond at proline residues.	Proline	120-127	peptidylprolyl isomerase like 3	Homo sapiens	55-61
27580037-7	2016	MSL2, the male-specific organizer of the complex, uses two distinct DNA interaction surfaces-the CXC and proline/basic-residue-rich domains-to identify complex DNA elements on the X chromosome.	Proline	105-112	male-specific lethal 2	Drosophila melanogaster	0-4
27628562-3	2016	We show that inhibiting hydroxylation of a proline residue within the N-terminal ankyrin repeat of human TRPA1 by mutation or using a prolyl hydroxylase (PHD) inhibitor potentiates the cold sensitivity of TRPA1 in the presence of hydrogen peroxide.	Proline	43-50	transient receptor potential cation channel subfamily A member 1	Homo sapiens	105-110
27628562-3	2016	We show that inhibiting hydroxylation of a proline residue within the N-terminal ankyrin repeat of human TRPA1 by mutation or using a prolyl hydroxylase (PHD) inhibitor potentiates the cold sensitivity of TRPA1 in the presence of hydrogen peroxide.	Proline	43-50	transient receptor potential cation channel subfamily A member 1	Homo sapiens	205-210
27622935-2	2016	The proline dehydrogenase (PRODH) gene, which encodes the enzyme that catalyzes proline catabolism, maps to human chromosome 22q11.2, a region conferring risk of schizophrenia.	Proline	4-11	proline dehydrogenase 1	Homo sapiens	27-32
27622935-3	2016	In the Prodh-null mouse, an interaction between elevated peripheral proline and another 22q11.2 gene, catechol-O-methyltransferase (COMT), on neurotransmission and behavior has been reported.	Proline	68-75	proline dehydrogenase	Mus musculus	7-12
27622935-3	2016	In the Prodh-null mouse, an interaction between elevated peripheral proline and another 22q11.2 gene, catechol-O-methyltransferase (COMT), on neurotransmission and behavior has been reported.	Proline	68-75	catechol-O-methyltransferase	Mus musculus	102-130
27622935-3	2016	In the Prodh-null mouse, an interaction between elevated peripheral proline and another 22q11.2 gene, catechol-O-methyltransferase (COMT), on neurotransmission and behavior has been reported.	Proline	68-75	catechol-O-methyltransferase	Mus musculus	132-136
27622935-7	2016	In COMT Val/Val patients, high proline was associated with low Scale for the Assessment of Negative Symptom (SANS) scores.	Proline	31-38	catechol-O-methyltransferase	Homo sapiens	3-7
27622935-7	2016	In COMT Val/Val patients, high proline was associated with low Scale for the Assessment of Negative Symptom (SANS) scores.	Proline	31-38	USH1 protein network component sans	Homo sapiens	109-113
27622935-8	2016	In contrast, high proline was associated with high SANS scores in patients carrying a Met allele.	Proline	18-25	USH1 protein network component sans	Homo sapiens	51-55
27622935-9	2016	The relationship between proline and COMT also appears to modify negative symptoms across psychiatric illness.	Proline	25-32	catechol-O-methyltransferase	Homo sapiens	37-41
27622935-12	2016	These data indicate a significant interaction between peripheral proline and COMT genotype, influencing negative symptoms in schizophrenia and bipolar disorder.	Proline	65-72	catechol-O-methyltransferase	Homo sapiens	77-81
27622935-13	2016	That high proline has converse effects on symptoms by COMT genotype, may have implications for therapeutic decisions.	Proline	10-17	catechol-O-methyltransferase	Homo sapiens	54-58
27614019-1	2016	The aminopeptidase DPP9 removes dipeptides from N-termini of substrates having a proline or alanine in second position.	Proline	81-88	dipeptidyl peptidase 9	Homo sapiens	19-23
27618008-3	2016	Once bound, Pin1 modulates the enzymatic activity, protein stability or subcellular localization of target proteins by changing the cis- and trans-formations of proline.	Proline	161-168	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	12-16
27551091-4	2016	The affinity for Sec23 is concentrated in the proline-rich domains (PRDs) of TANGO1 and cTAGE5, but Sec23 recognizes merely a PPP motif.	Proline	46-53	MIA SH3 domain ER export factor 3	Homo sapiens	77-83
27499440-5	2016	The CDC consensus undecapeptide motif, which for the CD59-responsive CDCs has a proline instead of a tryptophan in the motif, adopts a strikingly different conformation between the structures; our data suggest that the proline acts as a selectivity switch to ensure CD59-dependent CDCs bind their protein receptor first in preference to cholesterol.	Proline	80-87	CD59 molecule (CD59 blood group)	Homo sapiens	53-57
27499440-5	2016	The CDC consensus undecapeptide motif, which for the CD59-responsive CDCs has a proline instead of a tryptophan in the motif, adopts a strikingly different conformation between the structures; our data suggest that the proline acts as a selectivity switch to ensure CD59-dependent CDCs bind their protein receptor first in preference to cholesterol.	Proline	80-87	CD59 molecule (CD59 blood group)	Homo sapiens	266-270
27499440-5	2016	The CDC consensus undecapeptide motif, which for the CD59-responsive CDCs has a proline instead of a tryptophan in the motif, adopts a strikingly different conformation between the structures; our data suggest that the proline acts as a selectivity switch to ensure CD59-dependent CDCs bind their protein receptor first in preference to cholesterol.	Proline	219-226	CD59 molecule (CD59 blood group)	Homo sapiens	53-57
27499440-5	2016	The CDC consensus undecapeptide motif, which for the CD59-responsive CDCs has a proline instead of a tryptophan in the motif, adopts a strikingly different conformation between the structures; our data suggest that the proline acts as a selectivity switch to ensure CD59-dependent CDCs bind their protein receptor first in preference to cholesterol.	Proline	219-226	CD59 molecule (CD59 blood group)	Homo sapiens	266-270
27499442-7	2016	Pin1 binds promiscuously to phospho-Ser/Thr-Pro motifs, however, disparate structural and dynamic responses have been reported upon binding different ligands.	Proline	44-47	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
27551091-5	2016	The PRDs contain repeated PPP motifs separated by proline-rich linkers, so a single TANGO1/cTAGE5 receptor can bind multiple copies of coat protein in a close-packed array.	Proline	50-57	MIA SH3 domain ER export factor 3	Homo sapiens	84-90
27551091-5	2016	The PRDs contain repeated PPP motifs separated by proline-rich linkers, so a single TANGO1/cTAGE5 receptor can bind multiple copies of coat protein in a close-packed array.	Proline	50-57	MIA SH3 domain ER export factor 2	Homo sapiens	91-97
27551091-4	2016	The affinity for Sec23 is concentrated in the proline-rich domains (PRDs) of TANGO1 and cTAGE5, but Sec23 recognizes merely a PPP motif.	Proline	46-53	MIA SH3 domain ER export factor 2	Homo sapiens	88-94
27303048-2	2016	Upon relief from stress, proline is rapidly oxidized in mitochondria by proline dehydrogenase (ProDH) and then by pyrroline-5-carboxylate dehydrogenase (P5CDH).	Proline	25-32	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	72-93
27303048-2	2016	Upon relief from stress, proline is rapidly oxidized in mitochondria by proline dehydrogenase (ProDH) and then by pyrroline-5-carboxylate dehydrogenase (P5CDH).	Proline	25-32	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	95-100
27303048-2	2016	Upon relief from stress, proline is rapidly oxidized in mitochondria by proline dehydrogenase (ProDH) and then by pyrroline-5-carboxylate dehydrogenase (P5CDH).	Proline	25-32	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	114-151
27303048-2	2016	Upon relief from stress, proline is rapidly oxidized in mitochondria by proline dehydrogenase (ProDH) and then by pyrroline-5-carboxylate dehydrogenase (P5CDH).	Proline	25-32	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	153-158
27303048-7	2016	ProDH activity was high for genotypes in which ProDH, most likely ProDH1, was strongly induced by proline.	Proline	98-105	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	0-5
27373844-7	2016	We also identified a region of MGAT2 associated with the ER membrane that contains the histidine-proline-histidine-glycine sequence present in all DGAT2 family members that is thought to comprise the active site.	Proline	97-104	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	31-36
27303048-7	2016	ProDH activity was high for genotypes in which ProDH, most likely ProDH1, was strongly induced by proline.	Proline	98-105	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	47-52
32480511-6	2016	Additionally, proline biosynthesis Arabidopsis knockout (KO) mutant plants of Delta(1)-pyrroline-5-carboxylate synthetase1 (P5CS1) gene, designated as Atp5cs1-1 and Atp5cs1-4, showed similar protein nitration levels as wild-type plants under salinity-induced oxidative stress, despite mutants having higher levels of lipid oxidation, H2O2 and superoxide (O2 -).	Proline	14-21	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	78-122
27373844-7	2016	We also identified a region of MGAT2 associated with the ER membrane that contains the histidine-proline-histidine-glycine sequence present in all DGAT2 family members that is thought to comprise the active site.	Proline	97-104	diacylglycerol O-acyltransferase 2	Homo sapiens	147-152
27410463-1	2016	The enzyme members of the dipeptidyl peptidase 4 (DPP4) gene family have the very unusual capacity to cleave the post-proline bond to release dipeptides from the N-terminus of peptide/protein substrates.	Proline	118-125	dipeptidyl peptidase 4	Homo sapiens	26-48
27410463-1	2016	The enzyme members of the dipeptidyl peptidase 4 (DPP4) gene family have the very unusual capacity to cleave the post-proline bond to release dipeptides from the N-terminus of peptide/protein substrates.	Proline	118-125	dipeptidyl peptidase 4	Homo sapiens	50-54
27458189-4	2016	Here, we show that the synaptic component Proline rich 7 (PRR7) accumulates in the nucleus of hippocampal neurons following NMDAR activity.	Proline	42-49	proline rich 7, synaptic	Homo sapiens	58-62
27442630-1	2016	gamma-Glutamyl kinase (GK; the PRO1 gene product) is a key enzyme in the Saccharomyces cerevisiae proline biosynthesis pathway.	Proline	98-105	glutamate 5-kinase	Saccharomyces cerevisiae S288C	31-35
27586393-0	2016	Long non-coding RNA MALAT-1 modulates metastatic potential of tongue squamous cell carcinomas partially through the regulation of small proline rich proteins.	Proline	136-143	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	20-27
27380318-3	2016	Bioinformatics analysis indicated that the putative FAK protein contains an FERM domain, a PTK domain, two Proline-rich regions, and a focal adhesion-targeting (FAT) domain.	Proline	107-114	focal adhesion kinase 1	Capra hircus	52-55
32480511-6	2016	Additionally, proline biosynthesis Arabidopsis knockout (KO) mutant plants of Delta(1)-pyrroline-5-carboxylate synthetase1 (P5CS1) gene, designated as Atp5cs1-1 and Atp5cs1-4, showed similar protein nitration levels as wild-type plants under salinity-induced oxidative stress, despite mutants having higher levels of lipid oxidation, H2O2 and superoxide (O2 -).	Proline	14-21	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	124-129
32480511-6	2016	Additionally, proline biosynthesis Arabidopsis knockout (KO) mutant plants of Delta(1)-pyrroline-5-carboxylate synthetase1 (P5CS1) gene, designated as Atp5cs1-1 and Atp5cs1-4, showed similar protein nitration levels as wild-type plants under salinity-induced oxidative stress, despite mutants having higher levels of lipid oxidation, H2O2 and superoxide (O2 -).	Proline	14-21	pyrroline-5- carboxylate (P5C) reductase	Arabidopsis thaliana	165-174
27395781-1	2016	Dipeptidyl peptidase 4 (DPP 4) is a proline specific serine peptidase that plays an important role in different regulatory processes in mammals.	Proline	36-43	dipeptidyl peptidase 4	Homo sapiens	24-29
27526945-14	2016	In the analogs, the Pro(6) residue was replaced by Glu/Ala, and the SAR indicates that the nature of this residue plays a role in the biological function of these peptides.	Proline	20-23	sarcosinemia autosomal recessive	Mus musculus	68-71
27563086-0	2016	Proline hydroxylation linked to Akt activation.	Proline	0-7	AKT serine/threonine kinase 1	Homo sapiens	32-35
27562432-5	2016	The ECD deletion analysis of RHS10 indicates that proline residues, including AGP motifs, in the ECD are required for the root hair inhibition.	Proline	50-57	root hair specific 10	Arabidopsis thaliana	29-34
26310697-0	2016	The Trp53 delta proline (Trp53DeltaP) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development.	Proline	16-23	transformation related protein 53	Mus musculus	4-9
26310697-2	2016	The N-terminal proline-rich domain (PRD) of TP53 is important in the regulation of TP53 activity and stability.	Proline	15-22	transformation related protein 53	Mus musculus	44-48
26310697-2	2016	The N-terminal proline-rich domain (PRD) of TP53 is important in the regulation of TP53 activity and stability.	Proline	15-22	transformation related protein 53	Mus musculus	83-87
28348873-3	2016	Mutational analysis of the NS1 gene indicated that p23 was generated by a novel cleavage event within the linker domain between an aspartic acid and proline at amino acid residues at positions 92 and 93 respectively (DP92-93), and that p23 contained the first 92 amino acids of the NS1 protein.	Proline	149-156	influenza virus NS1A binding protein	Homo sapiens	27-30
28348873-3	2016	Mutational analysis of the NS1 gene indicated that p23 was generated by a novel cleavage event within the linker domain between an aspartic acid and proline at amino acid residues at positions 92 and 93 respectively (DP92-93), and that p23 contained the first 92 amino acids of the NS1 protein.	Proline	149-156	prostaglandin E synthase 3	Homo sapiens	51-54
27563096-0	2016	pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.	Proline	44-51	von Hippel-Lindau tumor suppressor	Homo sapiens	0-4
28348873-4	2016	Sequence analysis of the Singapore strains indicated the presence of either DP92-93 or NP92-93 in the NS1 protein, but protein expression analysis showed that p23 was only detected in NS1 proteins with DP92-93.. An additional adjacent proline residue at position 94 (P94) was present in some strains and correlated with increased p23 levels, suggesting that P94 has a synergistic effect on the cleavage of the NS1 protein.	Proline	235-242	prostaglandin E synthase 3	Homo sapiens	159-162
27563096-0	2016	pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.	Proline	44-51	AKT serine/threonine kinase 1	Homo sapiens	35-38
27552991-3	2016	The most common MDS mutations in SRSF2 occur at proline 95; the mutant proteins are shown to have different RNA binding preferences, which may contribute to splicing changes detected in mutant cells.	Proline	48-55	serine and arginine rich splicing factor 2	Homo sapiens	33-38
27467192-3	2016	However, using 1,5-DAN generates mainly c- and z-series ions by N-Calpha bond cleavage, which makes it difficult to distinguish leucine (Leu) and isoleucine (Ile), and frequently lacks c(n-1)-series ions owing to proline (Pro) at residues n. Several oxidizing matrices generating a- and x-series ions accompanied by d-series ions by Calpha-C bond cleavage have been reported, but an issue remained concerning their sensitivity.	Proline	213-220	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
27365391-6	2016	Interestingly, a proline at the N-terminal TM helix border, termed NBP, is critical to linker flexibility in integrins.	Proline	17-24	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	67-70
27467192-3	2016	However, using 1,5-DAN generates mainly c- and z-series ions by N-Calpha bond cleavage, which makes it difficult to distinguish leucine (Leu) and isoleucine (Ile), and frequently lacks c(n-1)-series ions owing to proline (Pro) at residues n. Several oxidizing matrices generating a- and x-series ions accompanied by d-series ions by Calpha-C bond cleavage have been reported, but an issue remained concerning their sensitivity.	Proline	222-225	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
27621818-11	2016	Based on the crystal structure of EBNA-1, we observed that this peptide resides at the base of an exposed proline rich loop in EBNA-1.	Proline	106-113	EBNA-1	Human gammaherpesvirus 4	34-40
27177841-2	2016	The new substrate, Dabcyl-Pro-Arg-Ala-Ala-Ala-Homophe-Thr-Ser-Pro-Lys(FAM)-NH2, has specificity constants of 6.3 (+-0.3) x 10(4) M(-1) s(-1) and 2.4 (+-0.3) x 10(3) M(-1) s(-1) for ADAM17 and ADAM10, respectively.	Proline	26-29	ADAM metallopeptidase domain 17	Homo sapiens	181-187
27177841-2	2016	The new substrate, Dabcyl-Pro-Arg-Ala-Ala-Ala-Homophe-Thr-Ser-Pro-Lys(FAM)-NH2, has specificity constants of 6.3 (+-0.3) x 10(4) M(-1) s(-1) and 2.4 (+-0.3) x 10(3) M(-1) s(-1) for ADAM17 and ADAM10, respectively.	Proline	26-29	ADAM metallopeptidase domain 10	Homo sapiens	192-198
27334924-5	2016	Truncation and alanine mutagenesis studies revealed that PP2Ac binds to the P3 block ((396)PAIPPKKPRP(405)) of the proline-rich region in CIN85.	Proline	115-122	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	57-62
27334924-5	2016	Truncation and alanine mutagenesis studies revealed that PP2Ac binds to the P3 block ((396)PAIPPKKPRP(405)) of the proline-rich region in CIN85.	Proline	115-122	SH3 domain containing kinase binding protein 1	Homo sapiens	138-143
27519903-0	2016	Two novel MYH7 proline substitutions cause Laing Distal Myopathy-like phenotypes with variable expressivity and neck extensor contracture.	Proline	15-22	myosin heavy chain 7	Homo sapiens	10-14
27519903-5	2016	RESULTS: Using whole exome sequencing we identified in both families two novel heterozygous proline substitutions located in exon 31 of MYH7 within its rod domain: c.4309G&gt;C (p.Ala1437Pro) and c.4301G&gt;C (p.Arg1434Pro).	Proline	92-99	myosin heavy chain 7	Homo sapiens	136-140
27316830-4	2016	An affinity tag comprised of a proline, a glycine and eight histidines was introduced into the C-terminal end of hPGHS-2.	Proline	31-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	113-120
27621818-11	2016	Based on the crystal structure of EBNA-1, we observed that this peptide resides at the base of an exposed proline rich loop in EBNA-1.	Proline	106-113	EBNA-1	Human gammaherpesvirus 4	127-133
27167730-4	2016	Proteomic analysis suggested that other proteins were also incorporated into the loricrin knockout cell envelope, in addition to the small proline rich proteins.	Proline	139-146	loricrin	Mus musculus	81-89
27480134-2	2016	However, the therapeutic activity of SDF-1alpha is potentially limited by N-terminal cleavage at position-2 proline by a cell surface protein CD26/dipeptidyl peptidase-IV (DPP-IV).	Proline	108-115	dipeptidylpeptidase 4	Rattus norvegicus	172-178
27480221-4	2016	Our results demonstrate that imatinib binding to the kinase domain effects dynamics of proline-rich or phosphorylated peptide ligand binding sites in distal c-Src SH3 and SH2 domains.	Proline	87-94	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	157-162
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Proline	137-144	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-8
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Proline	137-144	aldehyde dehydrogenase 18 family member A1	Homo sapiens	17-58
27346150-4	2016	The LcMAVS encodes 512 amino acids and contains a CARD, a proline-rich domain, a transmembrane helix domain and a putative TRAF2-binding motif ((269)PVQDT(273)).	Proline	58-65	mitochondrial antiviral-signaling protein	Larimichthys crocea	4-10
27317854-1	2016	Proline rich Akt substrate (PRAS40) is a component of mammalian target of rapamycin complex 1 (mTORC1) and is known to play an important role against reactive oxygen species-induced cell death.	Proline	0-7	AKT1 substrate 1	Homo sapiens	28-34
27317854-1	2016	Proline rich Akt substrate (PRAS40) is a component of mammalian target of rapamycin complex 1 (mTORC1) and is known to play an important role against reactive oxygen species-induced cell death.	Proline	0-7	CREB regulated transcription coactivator 1	Mus musculus	95-101
27443979-8	2016	By systematically evaluating the structural and energetic effects of different N-substituted amino acids presenting at the two proline sites on peptide binding, we rationally designed five peptoid inhibitors and then determined in vitro their binding affinity to hOSF SH3 domain.	Proline	127-134	osteoclast stimulating factor 1	Homo sapiens	263-267
26833688-5	2016	When cultured in YPD medium, there was a significant accumulation of proline in the put1 mutant strain, which is deficient in proline oxidase, in the stationary phase.	Proline	69-76	proline dehydrogenase	Saccharomyces cerevisiae S288C	84-88
27033553-6	2016	Real-time quantitative PCR (qRT-PCR) analysis showed that overexpression of AtMYB12 resulted in the up-regulation of genes involved in flavonoid biosynthesis, abscisic acid (ABA) biosynthesis, proline biosynthesis, stress responses and ROS scavenging under salt and drought stresses.	Proline	193-200	myb domain protein 12	Arabidopsis thaliana	76-83
27373508-12	2016	We propose that the differential expression of SNAT2 in the epiblast provides evidence for an l-proline-mediated mechanism contributing to the regulation of embryonic development.	Proline	94-103	solute carrier family 38 member 2	Homo sapiens	47-52
26833688-6	2016	Expression of the mutant PRO1 gene, which encodes the gamma-glutamyl kinase variant (Asp154Asn or Ile150Thr) with desensitization to feedback inhibition by proline in the put1 mutant strain, showed a prominent increase in proline content as compared with that of the wild-type strain.	Proline	156-163	glutamate 5-kinase	Saccharomyces cerevisiae S288C	25-29
26833688-6	2016	Expression of the mutant PRO1 gene, which encodes the gamma-glutamyl kinase variant (Asp154Asn or Ile150Thr) with desensitization to feedback inhibition by proline in the put1 mutant strain, showed a prominent increase in proline content as compared with that of the wild-type strain.	Proline	156-163	proline dehydrogenase	Saccharomyces cerevisiae S288C	171-175
26833688-6	2016	Expression of the mutant PRO1 gene, which encodes the gamma-glutamyl kinase variant (Asp154Asn or Ile150Thr) with desensitization to feedback inhibition by proline in the put1 mutant strain, showed a prominent increase in proline content as compared with that of the wild-type strain.	Proline	222-229	glutamate 5-kinase	Saccharomyces cerevisiae S288C	25-29
26833688-6	2016	Expression of the mutant PRO1 gene, which encodes the gamma-glutamyl kinase variant (Asp154Asn or Ile150Thr) with desensitization to feedback inhibition by proline in the put1 mutant strain, showed a prominent increase in proline content as compared with that of the wild-type strain.	Proline	222-229	proline dehydrogenase	Saccharomyces cerevisiae S288C	171-175
27378429-1	2016	l-Proline has been covalently attached in a rigid linear ligand, H4L, having an isophthalate moiety at each terminal to form the chiral ligand, H4LPRO.	Proline	0-9	H4 clustered histone 7	Homo sapiens	65-68
26923755-8	2016	Mutation analysis revealed a T&gt;C missense mutation at nucleotide 857 of the cDNA encoding endothelin receptor B (EDNRB) in which a proline was substituted for the highly conserved Lys-286 residue (L286P) in the fifth transmembrane (TM V) domain of this G protein-coupled receptor.	Proline	134-141	endothelin receptor type B	Mus musculus	93-114
26923755-8	2016	Mutation analysis revealed a T&gt;C missense mutation at nucleotide 857 of the cDNA encoding endothelin receptor B (EDNRB) in which a proline was substituted for the highly conserved Lys-286 residue (L286P) in the fifth transmembrane (TM V) domain of this G protein-coupled receptor.	Proline	134-141	endothelin receptor type B	Mus musculus	116-121
27436360-6	2016	The SH2 and proline-rich domains of TSAd bridged VEGFR2 and c-Src, and this bridging was critical for the localization of activated c-Src to endothelial junctions and elongation of the growing sprout, but not for selection of the tip cell.	Proline	12-19	SH2 domain containing 2A	Mus musculus	36-40
27436360-6	2016	The SH2 and proline-rich domains of TSAd bridged VEGFR2 and c-Src, and this bridging was critical for the localization of activated c-Src to endothelial junctions and elongation of the growing sprout, but not for selection of the tip cell.	Proline	12-19	kinase insert domain protein receptor	Mus musculus	49-55
27349982-3	2016	Here, we report the crystal structure of human ASM and describe the organization of the three main regions of the enzyme: the N-terminal saposin domain, the proline-rich connector, and the catalytic domain.	Proline	157-164	sphingomyelin phosphodiesterase 1	Homo sapiens	47-50
27507978-7	2016	We were able to observe defects in the deposition of cell wall proline rich protein PRP3 and cell wall polysaccharides.	Proline	63-70	pre-mRNA processing factor 3	Homo sapiens	84-88
27422518-5	2016	Mouse strain differences in the consumption of some sweet-tasting amino acids (d-phenylalanine, d-tryptophan, and l-proline) are associated with polymorphisms of a taste receptor, type 1, member 3 gene (Tas1r3), and involve differential peripheral taste responsiveness.	Proline	114-123	taste receptor, type 1, member 3	Mus musculus	164-196
27422518-5	2016	Mouse strain differences in the consumption of some sweet-tasting amino acids (d-phenylalanine, d-tryptophan, and l-proline) are associated with polymorphisms of a taste receptor, type 1, member 3 gene (Tas1r3), and involve differential peripheral taste responsiveness.	Proline	114-123	taste receptor, type 1, member 3	Mus musculus	203-209
27340743-4	2016	We demonstrate that the macromolecular MUC1 glycopeptide displaying the essential glycopeptidic neoepitope Pro-Asp-Thr(sialyl-T)-Arg-Pro-Ala-Pro at two different tandem repeats is an excellent serum MUC1 model showing ideal stoichiometric binding with anti-KL6/MUC1 antibody in the sandwich ELISA to quantify human serum KL6/MUC1 levels as a critical biomarker of interstitial lung diseases.	Proline	107-110	mucin 1, cell surface associated	Homo sapiens	39-43
27246536-1	2016	In the budding yeast Saccharomyces cerevisiae, the AVT genes (AVT1-7), which encode vacuolar amino acid transporters belonging to the amino acid vacuolar transport (AVT)-family, were significantly upregulated in response to exogenous proline.	Proline	234-241	Avt1p	Saccharomyces cerevisiae S288C	62-66
27246536-4	2016	Consistently, overexpression of the AVT1 gene specifically enhanced the vacuolar localization of proline.	Proline	97-104	Avt1p	Saccharomyces cerevisiae S288C	36-40
27246536-6	2016	In contrast, deletion of the AVT3 gene increased vacuolar proline, although the highly expressed AVT3 gene interfered with the accumulation of proline in the vacuole.	Proline	58-65	Avt3p	Saccharomyces cerevisiae S288C	29-33
27246536-6	2016	In contrast, deletion of the AVT3 gene increased vacuolar proline, although the highly expressed AVT3 gene interfered with the accumulation of proline in the vacuole.	Proline	143-150	Avt3p	Saccharomyces cerevisiae S288C	97-101
27246536-7	2016	Based on these results, it appears that Avt3 is the major protein involved in the export of proline from the vacuole.	Proline	92-99	Avt3p	Saccharomyces cerevisiae S288C	40-44
27340743-4	2016	We demonstrate that the macromolecular MUC1 glycopeptide displaying the essential glycopeptidic neoepitope Pro-Asp-Thr(sialyl-T)-Arg-Pro-Ala-Pro at two different tandem repeats is an excellent serum MUC1 model showing ideal stoichiometric binding with anti-KL6/MUC1 antibody in the sandwich ELISA to quantify human serum KL6/MUC1 levels as a critical biomarker of interstitial lung diseases.	Proline	107-110	mucin 1, cell surface associated	Homo sapiens	199-203
27340743-4	2016	We demonstrate that the macromolecular MUC1 glycopeptide displaying the essential glycopeptidic neoepitope Pro-Asp-Thr(sialyl-T)-Arg-Pro-Ala-Pro at two different tandem repeats is an excellent serum MUC1 model showing ideal stoichiometric binding with anti-KL6/MUC1 antibody in the sandwich ELISA to quantify human serum KL6/MUC1 levels as a critical biomarker of interstitial lung diseases.	Proline	107-110	mucin 1, cell surface associated	Homo sapiens	257-260
27340743-4	2016	We demonstrate that the macromolecular MUC1 glycopeptide displaying the essential glycopeptidic neoepitope Pro-Asp-Thr(sialyl-T)-Arg-Pro-Ala-Pro at two different tandem repeats is an excellent serum MUC1 model showing ideal stoichiometric binding with anti-KL6/MUC1 antibody in the sandwich ELISA to quantify human serum KL6/MUC1 levels as a critical biomarker of interstitial lung diseases.	Proline	107-110	mucin 1, cell surface associated	Homo sapiens	199-203
27340743-4	2016	We demonstrate that the macromolecular MUC1 glycopeptide displaying the essential glycopeptidic neoepitope Pro-Asp-Thr(sialyl-T)-Arg-Pro-Ala-Pro at two different tandem repeats is an excellent serum MUC1 model showing ideal stoichiometric binding with anti-KL6/MUC1 antibody in the sandwich ELISA to quantify human serum KL6/MUC1 levels as a critical biomarker of interstitial lung diseases.	Proline	107-110	mucin 1, cell surface associated	Homo sapiens	321-324
27340743-4	2016	We demonstrate that the macromolecular MUC1 glycopeptide displaying the essential glycopeptidic neoepitope Pro-Asp-Thr(sialyl-T)-Arg-Pro-Ala-Pro at two different tandem repeats is an excellent serum MUC1 model showing ideal stoichiometric binding with anti-KL6/MUC1 antibody in the sandwich ELISA to quantify human serum KL6/MUC1 levels as a critical biomarker of interstitial lung diseases.	Proline	107-110	mucin 1, cell surface associated	Homo sapiens	199-203
27040799-1	2016	Prolidase is a cytosolic imidodipeptidase that specifically splits imidodipeptides with C-terminal proline or hydroxyproline.	Proline	99-106	peptidase D	Homo sapiens	0-9
27040799-1	2016	Prolidase is a cytosolic imidodipeptidase that specifically splits imidodipeptides with C-terminal proline or hydroxyproline.	Proline	99-106	peptidase D	Homo sapiens	25-41
27040799-12	2016	PRODH/POX expression is often down-regulated in various tumors, limiting mitochondrial proline utilization to P5C.	Proline	87-94	proline dehydrogenase 1	Homo sapiens	0-9
27040799-14	2016	Proline availability for PRODH/POX-dependent ATP or ROS generation depends on activity of prolidase and utilization of proline in process of collagen biosynthesis.	Proline	0-7	proline dehydrogenase 1	Homo sapiens	25-30
27040799-14	2016	Proline availability for PRODH/POX-dependent ATP or ROS generation depends on activity of prolidase and utilization of proline in process of collagen biosynthesis.	Proline	0-7	proline dehydrogenase 1	Homo sapiens	31-34
27040799-14	2016	Proline availability for PRODH/POX-dependent ATP or ROS generation depends on activity of prolidase and utilization of proline in process of collagen biosynthesis.	Proline	0-7	peptidase D	Homo sapiens	90-99
27040799-14	2016	Proline availability for PRODH/POX-dependent ATP or ROS generation depends on activity of prolidase and utilization of proline in process of collagen biosynthesis.	Proline	119-126	proline dehydrogenase 1	Homo sapiens	25-30
27040799-14	2016	Proline availability for PRODH/POX-dependent ATP or ROS generation depends on activity of prolidase and utilization of proline in process of collagen biosynthesis.	Proline	119-126	proline dehydrogenase 1	Homo sapiens	31-34
27148834-1	2016	A leucine-to-proline missense mutation at residue 98 in the proline-serine-threonine phosphatase interacting protein 2 (Pstpip2) gene leads to autoinflammatory disease that is characterized by splenomegaly, necrosis, and spontaneous development of osteomyelitis in mice (Pstpip2cmo).	Proline	13-20	proline-serine-threonine phosphatase-interacting protein 2	Mus musculus	60-118
27148834-1	2016	A leucine-to-proline missense mutation at residue 98 in the proline-serine-threonine phosphatase interacting protein 2 (Pstpip2) gene leads to autoinflammatory disease that is characterized by splenomegaly, necrosis, and spontaneous development of osteomyelitis in mice (Pstpip2cmo).	Proline	13-20	proline-serine-threonine phosphatase-interacting protein 2	Mus musculus	120-127
27148834-1	2016	A leucine-to-proline missense mutation at residue 98 in the proline-serine-threonine phosphatase interacting protein 2 (Pstpip2) gene leads to autoinflammatory disease that is characterized by splenomegaly, necrosis, and spontaneous development of osteomyelitis in mice (Pstpip2cmo).	Proline	13-20	proline-serine-threonine phosphatase-interacting protein 2	Mus musculus	271-278
27130255-2	2016	This is an autosomal recessive disorder mapped to chromosome 1q42.12 due to mutations in the PYCR2 gene, encoding an enzyme involved in proline synthesis in mitochondria.	Proline	136-143	pyrroline-5-carboxylate reductase 2	Homo sapiens	93-98
27311421-8	2016	With respect to the molecular-level structure, it was found that the proline hydroxylation degree differed between WBS and healthy elastin, while the tropoelastin isoform appeared to be the same.	Proline	69-76	elastin	Homo sapiens	131-138
27230131-1	2016	OBJECTIVE: In a recent article in Arteriosclerosis, Thrombosis, and Vascular Biology, it was reported that ATP-binding cassette transporter G1 (ABCG1) containing leucine at position 550 (ABCG1-L550) was localized to the plasma membrane, whereas ABCG1-P550 (proline at position 550) was intracellular.	Proline	257-264	ATP binding cassette subfamily G member 1	Mus musculus	107-142
27458341-4	2016	These altered kinetics arise from the shift of a proline-induced translational pause site away from Htt"s localization sequence due to the expansion of the CAG-repeat segment between the poly-proline and localization sequences.	Proline	49-56	huntingtin	Homo sapiens	100-103
27230131-1	2016	OBJECTIVE: In a recent article in Arteriosclerosis, Thrombosis, and Vascular Biology, it was reported that ATP-binding cassette transporter G1 (ABCG1) containing leucine at position 550 (ABCG1-L550) was localized to the plasma membrane, whereas ABCG1-P550 (proline at position 550) was intracellular.	Proline	257-264	ATP binding cassette subfamily G member 1	Mus musculus	144-149
27230131-1	2016	OBJECTIVE: In a recent article in Arteriosclerosis, Thrombosis, and Vascular Biology, it was reported that ATP-binding cassette transporter G1 (ABCG1) containing leucine at position 550 (ABCG1-L550) was localized to the plasma membrane, whereas ABCG1-P550 (proline at position 550) was intracellular.	Proline	257-264	ATP binding cassette subfamily G member 1	Mus musculus	187-192
27230131-1	2016	OBJECTIVE: In a recent article in Arteriosclerosis, Thrombosis, and Vascular Biology, it was reported that ATP-binding cassette transporter G1 (ABCG1) containing leucine at position 550 (ABCG1-L550) was localized to the plasma membrane, whereas ABCG1-P550 (proline at position 550) was intracellular.	Proline	257-264	ATP binding cassette subfamily G member 1	Mus musculus	187-192
27230131-7	2016	CONCLUSIONS: ABCG1, irrespective of either a leucine or proline at position 550, is an intracellular protein that localizes to vesicles of the endosomal pathway where it functions to mobilize sterols away from the endoplasmic reticulum and out of the cell.	Proline	56-63	ATP binding cassette subfamily G member 1	Mus musculus	13-18
27135981-4	2016	Other NOTCH1 mutations in T-ALL and NOTCH1/2 mutations in multiple B-cell malignancies truncate the C-terminal proline (P), glutamic acid (E), serine (S), threonine (T)-rich (PEST) domain, leading to decreased Notch degradation after ligand-mediated activation.	Proline	111-118	notch receptor 1	Homo sapiens	6-12
26553387-6	2016	A significantly increased breast cancer risk was associated with the Proline allele [odds ratio 1.84 (95 % CI: 1.22-2.77), risk ratio 1.34 (95 % CI: 1.11-1.63), p value 0.003], HER2/neu status (p = 0.01) and distant metastasis (p = 0.05).	Proline	69-76	erb-b2 receptor tyrosine kinase 2	Homo sapiens	177-181
26553387-6	2016	A significantly increased breast cancer risk was associated with the Proline allele [odds ratio 1.84 (95 % CI: 1.22-2.77), risk ratio 1.34 (95 % CI: 1.11-1.63), p value 0.003], HER2/neu status (p = 0.01) and distant metastasis (p = 0.05).	Proline	69-76	erb-b2 receptor tyrosine kinase 2	Homo sapiens	182-185
26919392-1	2016	CD26/DPP4 (dipeptidyl peptidase 4/DP4/DPPIV) is a surface T cell activation antigen and has been shown to have DPP4 enzymatic activity, cleaving-off amino-terminal dipeptides with either L-proline or L-alanine at the penultimate position.	Proline	187-196	dipeptidyl peptidase 4	Homo sapiens	0-4
26919392-1	2016	CD26/DPP4 (dipeptidyl peptidase 4/DP4/DPPIV) is a surface T cell activation antigen and has been shown to have DPP4 enzymatic activity, cleaving-off amino-terminal dipeptides with either L-proline or L-alanine at the penultimate position.	Proline	187-196	dipeptidyl peptidase 4	Homo sapiens	5-9
26919392-1	2016	CD26/DPP4 (dipeptidyl peptidase 4/DP4/DPPIV) is a surface T cell activation antigen and has been shown to have DPP4 enzymatic activity, cleaving-off amino-terminal dipeptides with either L-proline or L-alanine at the penultimate position.	Proline	187-196	dipeptidyl peptidase 4	Homo sapiens	11-33
26919392-1	2016	CD26/DPP4 (dipeptidyl peptidase 4/DP4/DPPIV) is a surface T cell activation antigen and has been shown to have DPP4 enzymatic activity, cleaving-off amino-terminal dipeptides with either L-proline or L-alanine at the penultimate position.	Proline	187-196	transcription factor Dp family member 3	Homo sapiens	34-37
26919392-1	2016	CD26/DPP4 (dipeptidyl peptidase 4/DP4/DPPIV) is a surface T cell activation antigen and has been shown to have DPP4 enzymatic activity, cleaving-off amino-terminal dipeptides with either L-proline or L-alanine at the penultimate position.	Proline	187-196	dipeptidyl peptidase 4	Homo sapiens	38-43
26919392-1	2016	CD26/DPP4 (dipeptidyl peptidase 4/DP4/DPPIV) is a surface T cell activation antigen and has been shown to have DPP4 enzymatic activity, cleaving-off amino-terminal dipeptides with either L-proline or L-alanine at the penultimate position.	Proline	187-196	dipeptidyl peptidase 4	Homo sapiens	111-115
27135981-4	2016	Other NOTCH1 mutations in T-ALL and NOTCH1/2 mutations in multiple B-cell malignancies truncate the C-terminal proline (P), glutamic acid (E), serine (S), threonine (T)-rich (PEST) domain, leading to decreased Notch degradation after ligand-mediated activation.	Proline	111-118	notch receptor 1	Homo sapiens	36-44
26876646-7	2016	Comparison of the mterf6-1 transcriptome with that of prors1-2 showed that reduced aminoacylation of proline (prors1-2) and isoleucine (mterf6-1) tRNAs alters retrograde signaling in similar ways.	Proline	101-108	Class II aaRS and biotin synthetases superfamily protein	Arabidopsis thaliana	54-60
27431629-1	2016	CD26 is a 110 kDa, type II transmembrane glycoprotein with dipeptidyl peptidase IV activity and is capable of cleaving Nterminal dipeptides with either L-proline or L-alanine at the penultimate position.	Proline	152-161	dipeptidyl peptidase 4	Homo sapiens	0-4
27322059-6	2016	DKK1/CKAP4 signaling activated AKT by forming a complex between the proline-rich domain of CKAP4 and the Src homology 3 domain of PI3K, resulting in proliferation of normal cells and cancer cells.	Proline	68-75	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	0-4
27322059-6	2016	DKK1/CKAP4 signaling activated AKT by forming a complex between the proline-rich domain of CKAP4 and the Src homology 3 domain of PI3K, resulting in proliferation of normal cells and cancer cells.	Proline	68-75	cytoskeleton associated protein 4	Homo sapiens	5-10
27322059-6	2016	DKK1/CKAP4 signaling activated AKT by forming a complex between the proline-rich domain of CKAP4 and the Src homology 3 domain of PI3K, resulting in proliferation of normal cells and cancer cells.	Proline	68-75	AKT serine/threonine kinase 1	Homo sapiens	31-34
27322059-6	2016	DKK1/CKAP4 signaling activated AKT by forming a complex between the proline-rich domain of CKAP4 and the Src homology 3 domain of PI3K, resulting in proliferation of normal cells and cancer cells.	Proline	68-75	cytoskeleton associated protein 4	Homo sapiens	91-96
26921470-4	2016	We are able to show that this effect by APP-ICD is due to a single alanine vs. proline difference between APP-ICD and APLP2-ICD.	Proline	79-86	amyloid beta precursor like protein 2	Homo sapiens	118-123
26921470-5	2016	The alanine in APP-ICD and the proline in APLP2-ICD lie directly behind a conserved caspase cleavage site.	Proline	31-38	amyloid beta precursor like protein 2	Homo sapiens	42-47
26921470-8	2016	The block in long-term potentiation can be overcome by mutating the aforementioned alanine in APP-ICD to the proline of APLP2.	Proline	109-116	amyloid beta precursor like protein 2	Homo sapiens	120-125
26876646-7	2016	Comparison of the mterf6-1 transcriptome with that of prors1-2 showed that reduced aminoacylation of proline (prors1-2) and isoleucine (mterf6-1) tRNAs alters retrograde signaling in similar ways.	Proline	101-108	Class II aaRS and biotin synthetases superfamily protein	Arabidopsis thaliana	110-116
27445835-2	2016	FHM type 4 is attributed to mutations in the PRRT2 gene, which encodes a proline-rich transmembrane protein of as yet unknown function.	Proline	73-80	proline rich transmembrane protein 2	Homo sapiens	45-50
27159346-3	2016	The WRK-derived probes show unique reactivity towards the catalytic N-terminal proline in the macrophage migration inhibitory factor (MIF) and can be used to label and, if equipped with a fluorophore, to image MIF activities in living cells.	Proline	79-86	macrophage migration inhibitory factor	Homo sapiens	94-132
27159346-3	2016	The WRK-derived probes show unique reactivity towards the catalytic N-terminal proline in the macrophage migration inhibitory factor (MIF) and can be used to label and, if equipped with a fluorophore, to image MIF activities in living cells.	Proline	79-86	macrophage migration inhibitory factor	Homo sapiens	134-137
27159346-3	2016	The WRK-derived probes show unique reactivity towards the catalytic N-terminal proline in the macrophage migration inhibitory factor (MIF) and can be used to label and, if equipped with a fluorophore, to image MIF activities in living cells.	Proline	79-86	macrophage migration inhibitory factor	Homo sapiens	210-213
27343349-3	2016	Mia40 consists of two functional elements: an N-terminal cysteine-proline-cysteine motif conferring substrate oxidation, and a C-terminal hydrophobic pocket for substrate binding.	Proline	66-73	Mia40p	Saccharomyces cerevisiae S288C	0-5
27332121-0	2016	Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl.	Proline	60-67	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	83-87
27332121-1	2016	The N-terminal Src homology 3 (nSH3) domain of a signaling adaptor protein, CT-10 regulator of kinase II (CrkII), recognizes proline-rich motifs (PRMs) of binding partners, such as cAbl kinase.	Proline	125-132	CRK proto-oncogene, adaptor protein	Homo sapiens	76-104
27332121-1	2016	The N-terminal Src homology 3 (nSH3) domain of a signaling adaptor protein, CT-10 regulator of kinase II (CrkII), recognizes proline-rich motifs (PRMs) of binding partners, such as cAbl kinase.	Proline	125-132	CRK proto-oncogene, adaptor protein	Homo sapiens	106-111
27332121-1	2016	The N-terminal Src homology 3 (nSH3) domain of a signaling adaptor protein, CT-10 regulator of kinase II (CrkII), recognizes proline-rich motifs (PRMs) of binding partners, such as cAbl kinase.	Proline	125-132	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	181-185
27482243-2	2016	The prolidase enzyme is a cytosolic exopeptidase that detaches proline or hydroxyproline from the carboxyl terminal position of dipeptides.	Proline	63-70	peptidase D	Homo sapiens	4-13
27345869-5	2016	Considering the potential involvement of the T/SP motifs as putative phosphorylation sites, we also show that proline-directed Ser/Thr kinase CDK5 modulates the activity of TRPA1, and that T673 outside the AR-domain is its only possible target.	Proline	110-117	cyclin dependent kinase 5	Homo sapiens	142-146
27345869-5	2016	Considering the potential involvement of the T/SP motifs as putative phosphorylation sites, we also show that proline-directed Ser/Thr kinase CDK5 modulates the activity of TRPA1, and that T673 outside the AR-domain is its only possible target.	Proline	110-117	transient receptor potential cation channel subfamily A member 1	Homo sapiens	173-178
27329107-3	2016	METHODS: A series of synthesized alpha-Syn peptides, corresponding to the locus in FL-alpha-Syn containing alanine 30, substitution of which with a proline causes a familial form of Parkinson"s disease, were examined for their capacity of inducing release of microglial superoxide.	Proline	148-155	synuclein, alpha	Mus musculus	33-42
27161995-5	2016	The analysis suggests that tyrosine phosphorylation of SH3 domains found in Abl kinases act as a switch that can induce both the loss and, unexpectedly, gain of affinity for proline-rich ligands.	Proline	174-181	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	76-79
27312851-6	2016	DAPK thereby promotes the proline hydroxylation and proteasome degradation of HIF-1alpha.	Proline	26-33	hypoxia inducible factor 1, alpha subunit	Mus musculus	78-88
32263314-3	2016	To this end, we prepared and characterized the matrix metalloprotease-2 (MMP-2)/MMP-9-sensitive linker of the proline-valine-glycine-leucine-isoleucine-glycine (Pro-Val-Gly-Leu-Ile-Gly, PVGLIG) oligopeptide via a convenient and fast liquid-phase synthesis.	Proline	110-117	matrix metallopeptidase 2	Mus musculus	47-71
27227417-0	2016	Correction to Multiple Src Homology 3 Binding to the Ubiquitin Ligase Itch Conserved Proline-Rich Region.	Proline	85-92	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	23-26
32263314-3	2016	To this end, we prepared and characterized the matrix metalloprotease-2 (MMP-2)/MMP-9-sensitive linker of the proline-valine-glycine-leucine-isoleucine-glycine (Pro-Val-Gly-Leu-Ile-Gly, PVGLIG) oligopeptide via a convenient and fast liquid-phase synthesis.	Proline	110-117	matrix metallopeptidase 2	Mus musculus	73-78
32263314-3	2016	To this end, we prepared and characterized the matrix metalloprotease-2 (MMP-2)/MMP-9-sensitive linker of the proline-valine-glycine-leucine-isoleucine-glycine (Pro-Val-Gly-Leu-Ile-Gly, PVGLIG) oligopeptide via a convenient and fast liquid-phase synthesis.	Proline	110-117	matrix metallopeptidase 9	Mus musculus	80-85
27303796-5	2016	Here, it is reported that L-proline stabilizes purified NONO homodimers, enabling good-quality solution small-angle X-ray structure determination and crystallization.	Proline	26-35	non-POU domain containing octamer binding	Homo sapiens	56-60
27107639-0	2016	A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila.	Proline	54-61	spaghetti squash	Drosophila melanogaster	69-75
27107639-1	2016	An "invariant proline" separates the myosin S1 head from its S2 tail and is proposed to be critical for orienting S1 during its interaction with actin, a process that leads to muscle contraction.	Proline	14-21	spaghetti squash	Drosophila melanogaster	37-43
27095734-6	2016	Proteins involved in RNA splicing such as serine/arginine-rich splicing factor 2 (SRSF2) and splicing factor and proline- and glutamine-rich (SFPQ) were stabilized with DMOG.	Proline	113-120	splicing factor proline and glutamine rich	Homo sapiens	142-146
27285299-6	2016	CONCLUSION: CRAMP synergistically enhances the activity of proline-rich AMPs, which will allow evaluating their therapeutic potential more precisely in vitro.	Proline	59-66	cathelicidin antimicrobial peptide	Mus musculus	12-17
27304453-10	2016	The results revealed that (1) homozygosity of the Pro72 variant of p53 was present in 26 laryngeal carcinoma patients (65%), (2) heterozygosity for the Pro/Arg genotype was present in 13 patients (32.5%), and (3) the Arg72 variant of the p53 allele was present in 1 patient (2.5%) before treatment.	Proline	50-53	tumor protein p53	Homo sapiens	67-70
26965428-7	2016	Moreover, mutant with simultaneous deletion of NTH1 and PUT1 exhibits the highest relative dough-leavening ability after freezing compared to mutants with single-gene deletion perhaps due to elevated levels of both trehalose and proline.	Proline	229-236	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	47-51
26965428-7	2016	Moreover, mutant with simultaneous deletion of NTH1 and PUT1 exhibits the highest relative dough-leavening ability after freezing compared to mutants with single-gene deletion perhaps due to elevated levels of both trehalose and proline.	Proline	229-236	proline dehydrogenase	Saccharomyces cerevisiae S288C	56-60
26988064-1	2016	BACKGROUND: Dipeptidyl peptidase 4 (DPP4; EC 3.4.14.5; CD26) is a membrane-bound or shedded serine protease that hydrolyzes dipeptides from the N-terminus of peptides with either proline or alanine at the penultimate position.	Proline	179-186	dipeptidyl peptidase 4	Homo sapiens	12-34
26991250-4	2016	Pin1, a peptidyl-prolyl cis/trans isomerase (PPIase) that recognizes and binds to phosphorylated serine/threonine residues preceded by a proline (pSer/Thr-Pro) is also expressed in the developing brain.	Proline	137-144	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
26991250-4	2016	Pin1, a peptidyl-prolyl cis/trans isomerase (PPIase) that recognizes and binds to phosphorylated serine/threonine residues preceded by a proline (pSer/Thr-Pro) is also expressed in the developing brain.	Proline	137-144	peptidylprolyl isomerase (cyclophilin)-like 3	Mus musculus	8-43
26991250-4	2016	Pin1, a peptidyl-prolyl cis/trans isomerase (PPIase) that recognizes and binds to phosphorylated serine/threonine residues preceded by a proline (pSer/Thr-Pro) is also expressed in the developing brain.	Proline	137-144	peptidylprolyl isomerase (cyclophilin)-like 3	Mus musculus	45-51
27376811-2	2016	The change from an arginine (Arg) to a proline (Pro) at codon 72 can influence the biological activity of p53, which predisposes to an increased risk of recurrent spontaneous abortion (RSA).	Proline	39-46	tumor protein p53	Homo sapiens	106-109
27376811-2	2016	The change from an arginine (Arg) to a proline (Pro) at codon 72 can influence the biological activity of p53, which predisposes to an increased risk of recurrent spontaneous abortion (RSA).	Proline	48-51	tumor protein p53	Homo sapiens	106-109
27376811-7	2016	There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not.	Proline	101-104	tumor protein p53	Homo sapiens	44-47
27376811-7	2016	There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not.	Proline	105-108	tumor protein p53	Homo sapiens	44-47
27376811-7	2016	There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not.	Proline	105-108	tumor protein p53	Homo sapiens	44-47
27376811-7	2016	There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not.	Proline	105-108	tumor protein p53	Homo sapiens	44-47
27376811-7	2016	There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not.	Proline	105-108	tumor protein p53	Homo sapiens	44-47
27109316-6	2016	This somatic missense mutation led to the conversion of proline to leucine (p.P354L), resulting in deleterious effects for the NBN protein.	Proline	56-63	nibrin	Homo sapiens	127-130
26988064-1	2016	BACKGROUND: Dipeptidyl peptidase 4 (DPP4; EC 3.4.14.5; CD26) is a membrane-bound or shedded serine protease that hydrolyzes dipeptides from the N-terminus of peptides with either proline or alanine at the penultimate position.	Proline	179-186	dipeptidyl peptidase 4	Homo sapiens	36-40
26988064-1	2016	BACKGROUND: Dipeptidyl peptidase 4 (DPP4; EC 3.4.14.5; CD26) is a membrane-bound or shedded serine protease that hydrolyzes dipeptides from the N-terminus of peptides with either proline or alanine at the penultimate position.	Proline	179-186	dipeptidyl peptidase 4	Homo sapiens	55-59
27171135-6	2016	Our results indicate that the DI domain has a more negative impact than the DII domain does on binding to IR, and that the DI domain Pro-Leu-Lys residues are important factors for a different IR-A versus IR-B binding affinity of IGF-1.	Proline	133-136	insulin like growth factor 1	Homo sapiens	229-234
27073025-3	2016	Pin1 recognizes phosphoserine/phosphothreonine-proline motifs in target proteins and catalyzes prolyl isomerization at the peptide bond.	Proline	47-54	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
27073025-9	2016	Evidence is also presented that this mechanism of eNOS regulation cannot occur in rat and mouse cells because there is no proline residue in the mouse and rat amino acid sequences adjacent to the putative phosphorylation site.	Proline	122-129	nitric oxide synthase 3	Rattus norvegicus	50-54
27030529-6	2016	The HRG proline or serine peptides were added to cultures of primary human endometrial endothelial (HEE) cells and to human embryos in vitro.	Proline	8-15	histidine rich glycoprotein	Homo sapiens	4-7
26985769-4	2016	FAP alpha has both dipeptidyl peptidase and endopeptidase activities, cleaving substrates at a post-proline bond.	Proline	100-107	fibroblast activation protein	Mus musculus	0-9
27258420-5	2016	We found similar protein and mRNA levels of the major cholinergic "tailed"-variant (AChE-T) and the anchoring subunit, proline-rich membrane anchor (PRiMA-1) in frontal cortex obtained from AD patients and non-demented controls.	Proline	119-126	proline rich membrane anchor 1	Homo sapiens	149-156
27193083-8	2016	Here we report the identification of critical proline residues, Pro213, Pro216, and Pro219, located within the fifth and sixth Pro-X-X-Pro motifs in the proline-rich region of tau, that are important for its binding to fyn.	Proline	46-53	microtubule associated protein tau	Homo sapiens	176-179
27193083-8	2016	Here we report the identification of critical proline residues, Pro213, Pro216, and Pro219, located within the fifth and sixth Pro-X-X-Pro motifs in the proline-rich region of tau, that are important for its binding to fyn.	Proline	46-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	219-222
27193083-8	2016	Here we report the identification of critical proline residues, Pro213, Pro216, and Pro219, located within the fifth and sixth Pro-X-X-Pro motifs in the proline-rich region of tau, that are important for its binding to fyn.	Proline	153-160	microtubule associated protein tau	Homo sapiens	176-179
27193083-8	2016	Here we report the identification of critical proline residues, Pro213, Pro216, and Pro219, located within the fifth and sixth Pro-X-X-Pro motifs in the proline-rich region of tau, that are important for its binding to fyn.	Proline	153-160	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	219-222
26991332-2	2016	The combination of proline and a urea Bronsted base cocatalyst is key for the reactions to proceed under very mild conditions (3-10 mol % catalyst loading, dichloromethane as solvent, -20  C, 1.2 molar equivalents of aldehyde) and with virtually total stereocontrol (syn/anti ratio up to 99:1; ee up to 99 %).	Proline	19-26	synemin	Homo sapiens	267-270
27194325-1	2016	UNLABELLED: Phosphorylation of serine/threonine residues preceding a proline regulates the fate of its targets through postphosphorylation conformational changes catalyzed by the peptidyl-prolyl cis-/trans isomerase Pin1.	Proline	69-76	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	216-220
27194325-5	2016	Pin1 recruitment by PSD-95 occurs at specific serine-threonine/proline consensus motifs localized in the linker region connecting PDZ2 to PDZ3 domains.	Proline	63-70	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
27194325-5	2016	Pin1 recruitment by PSD-95 occurs at specific serine-threonine/proline consensus motifs localized in the linker region connecting PDZ2 to PDZ3 domains.	Proline	63-70	discs large MAGUK scaffold protein 4	Mus musculus	20-26
27194325-11	2016	The activity of PSD-95 is tightly controlled by several post-translational mechanisms including proline-directed phosphorylation.	Proline	96-103	discs large MAGUK scaffold protein 4	Mus musculus	16-22
26996940-3	2016	Of those phosphorylation sites, 17 precede a proline, making them potential recognition sites for the peptidyl-prolyl isomerase Pin1.	Proline	45-52	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	128-132
27009202-9	2016	SH3 domains usually interact with a proline-rich consensus sequence, but the region of paramyosin that interacts with UNC-89"s SH3 is alpha-helical and lacks prolines.	Proline	36-43	Paramyosin	Caenorhabditis elegans	87-97
27159678-3	2016	Single-nucleotide polymorphism of p53 at codon72 leading to substitution of proline (Pro) in place of arginine (Arg) has been identified as a risk factor for development of many cancers, including nasopharyngeal carcinoma (NPC).	Proline	76-83	tumor protein p53	Homo sapiens	34-37
27159678-3	2016	Single-nucleotide polymorphism of p53 at codon72 leading to substitution of proline (Pro) in place of arginine (Arg) has been identified as a risk factor for development of many cancers, including nasopharyngeal carcinoma (NPC).	Proline	85-88	tumor protein p53	Homo sapiens	34-37
26996941-6	2016	We find that phosphorylated (p-) SER235-PRO, but not pTHR231-PRO, is exclusively catalyzed by full-length Pin1 and isolated PPIase domain.	Proline	40-43	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	106-110
30695419-1	2016	The inhibitors of proline specific peptidase dipeptidyl peptidase-IV (DPP-IV, CD 26; EC 3.4.14.5) diprotin A (2 mg/kg) and sitagliptin (4 mg/kg) upon daily systemic exposure in rat pups on postnatal days 1-7 induced emotional and motivational disorders in one- and two-month-old rats.	Proline	18-25	dipeptidylpeptidase 4	Rattus norvegicus	45-68
26760307-5	2016	Human MMP-12 efficiently cleaved peptide substrates containing a Pro at P3 in the sequence Pro-X-X Leu but lacked selectivity towards these substrates compared to other MMPs, including MMP-2, MMP-7, MMP-9 and MMP-13.	Proline	65-68	matrix metallopeptidase 12	Homo sapiens	6-12
26763595-3	2016	While structural disorder of hydrophobic sequences is controlled by a high proline and glycine residue composition, hydrophobic domain 30 of human tropoelastin is atypically proline-poor, and forms beta-sheet amyloid-like fibrils as an individual peptide.	Proline	174-181	elastin	Homo sapiens	147-159
27569097-1	2016	PURPOSE: To find a possible association between the Mouse Double Minute 2(MDM2) 344T&gt;A, alone and in combination with p53 72 Arg/Pro polymorphism, and resistance to anthracycline-based chemotherapy of breast cancer in Tunisia.	Proline	132-135	transformation related protein 53, pseudogene	Mus musculus	121-124
26920026-2	2016	In contrast with other members of the family, the N-terminal domain of PRELP has a high content of proline and positively charged amino acids.	Proline	99-106	proline and arginine rich end leucine rich repeat protein	Rattus norvegicus	71-76
27073898-8	2016	The accumulated content of osmotic adjustment substances, such as proline, in TaEXPA2 transgenic plants was greater than that in WT plants.	Proline	66-73	expA2	Triticum aestivum	78-85
26775739-0	2016	Reconstitution and spectroscopic analysis of caveolin-1 residues 62-178 reveals that proline 110 governs its structure and solvent exposure.	Proline	85-92	caveolin 1	Homo sapiens	45-55
26967252-12	2016	Within arginine and proline metabolism, levels of intermediate metabolites in creatine pathway were all significantly lower in IDH mutation positive than in negative patients, suggesting an increased activity of creatine pathway in IDH mutation positive tumors.	Proline	20-27	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	127-130
26997484-2	2016	The cytoplasmic C terminus of Kv3.3 contains a proline-rich domain conserved in proteins that activate actin nucleation through Arp2/3.	Proline	47-54	potassium voltage-gated channel subfamily C member 3	Homo sapiens	30-35
26997484-2	2016	The cytoplasmic C terminus of Kv3.3 contains a proline-rich domain conserved in proteins that activate actin nucleation through Arp2/3.	Proline	47-54	actin related protein 2	Homo sapiens	128-134
26997484-6	2016	A human Kv3.3 mutation within a conserved proline-rich domain produces channels that bind Hax-1 but are impaired in recruiting Arp2/3 to the plasma membrane, resulting in growth cones with deficient actin veils in stem cell-derived neurons.	Proline	42-49	potassium voltage-gated channel subfamily C member 3	Homo sapiens	8-13
26997484-6	2016	A human Kv3.3 mutation within a conserved proline-rich domain produces channels that bind Hax-1 but are impaired in recruiting Arp2/3 to the plasma membrane, resulting in growth cones with deficient actin veils in stem cell-derived neurons.	Proline	42-49	HCLS1 associated protein X-1	Homo sapiens	90-95
26997484-6	2016	A human Kv3.3 mutation within a conserved proline-rich domain produces channels that bind Hax-1 but are impaired in recruiting Arp2/3 to the plasma membrane, resulting in growth cones with deficient actin veils in stem cell-derived neurons.	Proline	42-49	actin related protein 2	Homo sapiens	127-133
27045366-0	2016	Expression of Estrogen Receptor Coactivator Proline-, Glutamic Acid- and Leucine-Rich Protein 1 within Paraspinal Muscles in Adolescents with Idiopathic Scoliosis.	Proline	44-51	estrogen receptor 1	Homo sapiens	14-31
26692170-6	2016	Two mutations in CYB5D2, the substitutions of arginine (R) 7 with either proline (P) or glycine (G), were reported in colon cancer.	Proline	73-80	cytochrome b5 domain containing 2	Homo sapiens	17-23
26775739-9	2016	Overall, this work provides strong evidence that proline 110 is critical for maintaining both the structure and hydrophobic coverage of caveolin-1 and that cholesterol also plays a significant role in modulating these parameters.	Proline	49-56	caveolin 1	Homo sapiens	136-146
26775739-7	2016	This finding provided evidence that regions proximal and far away from the proline are buried differentially upon its mutation and therefore this residue is strongly tied to maintaining the hydrophobic coverage along the caveolin-1 sequence.	Proline	75-82	caveolin 1	Homo sapiens	221-231
27356594-2	2016	These enzymes are in the organisms either soluble or anchored through anchoring proteins collagen Q (ColQ) and proline-rich membrane anchor (PRiMA).	Proline	111-118	proline rich membrane anchor 1	Mus musculus	141-146
26931172-11	2016	Tendergreen) were analyzed to determine the symbiotic effector activity of different NopL variants with serine to alanine substitutions at identified and predicted phosphorylation sites (serine-proline motif).	Proline	194-201	type II secretion system effector nodulation protein NopL	Sinorhizobium fredii NGR234	85-89
26846855-3	2016	Here, we show that erythropoietin receptor (EPOR) is hydroxylated on proline 419 and 426 via prolyl hydroxylase 3.	Proline	69-76	erythropoietin receptor	Homo sapiens	19-42
26846855-3	2016	Here, we show that erythropoietin receptor (EPOR) is hydroxylated on proline 419 and 426 via prolyl hydroxylase 3.	Proline	69-76	erythropoietin receptor	Homo sapiens	44-48
26931172-13	2016	In conclusion, our findings provide evidence that NopL interacts with MAP kinases and reveals the importance of serine-proline motifs for effector activity during symbiosis.	Proline	119-126	type II secretion system effector nodulation protein NopL	Sinorhizobium fredii NGR234	50-54
26682513-9	2016	In GluK2/GluK5 heteromers, enhanced permeation is due to a single proline residue in GluK5 that alters the dynamics of the alpha-helical region of the selectivity filter.	Proline	66-73	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	3-8
26742712-8	2016	(18)F-IL-8 was produced using the cell-free translation system with trans-(18)F-FPro instead of natural L-proline with incubation at 37 C for 120 min.	Proline	104-113	chemokine (C-X-C motif) ligand 15	Mus musculus	6-10
26682513-2	2016	Relief of polyamine block in GluK2/GluK5 heteromers results from a key proline residue that produces architectural changes in the channel pore alpha-helical region.	Proline	71-78	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	29-34
26682513-9	2016	In GluK2/GluK5 heteromers, enhanced permeation is due to a single proline residue in GluK5 that alters the dynamics of the alpha-helical region of the selectivity filter.	Proline	66-73	glutamate ionotropic receptor kainate type subunit 5	Homo sapiens	9-14
26682513-9	2016	In GluK2/GluK5 heteromers, enhanced permeation is due to a single proline residue in GluK5 that alters the dynamics of the alpha-helical region of the selectivity filter.	Proline	66-73	glutamate ionotropic receptor kainate type subunit 5	Homo sapiens	85-90
26682513-2	2016	Relief of polyamine block in GluK2/GluK5 heteromers results from a key proline residue that produces architectural changes in the channel pore alpha-helical region.	Proline	71-78	glutamate ionotropic receptor kainate type subunit 5	Homo sapiens	35-40
26963408-7	2016	Motifs that included sequential proline and glycine showed a CDR3 length independent distribution and examining codon usage indicates that a large proportion of these can be explained by P-nucleotide addition from the 5" end of the D region.	Proline	32-39	CDR3	Homo sapiens	61-65
28955869-5	2016	Dock8, through its unique N-terminal proline-rich motif, interacts with the SH3 domain of Nck1, but not with other adaptor proteins composed only of SH domains, e.g. Grb2 and CrkII, and not with the adaptor protein Elmo1.	Proline	37-44	dedicator of cytokinesis 8	Rattus norvegicus	0-5
27563695-7	2016	MafA, insulin 1, and the cytochrome c oxidase subunit VIa polypeptide 2 mRNA expressions were all downregulated, indicating that proline impaired insulin gene transcription and mitochondrial oxidative phosphorylation.	Proline	129-136	MAF bZIP transcription factor A	Rattus norvegicus	0-4
27563695-7	2016	MafA, insulin 1, and the cytochrome c oxidase subunit VIa polypeptide 2 mRNA expressions were all downregulated, indicating that proline impaired insulin gene transcription and mitochondrial oxidative phosphorylation.	Proline	129-136	insulin 1	Rattus norvegicus	6-15
28955869-5	2016	Dock8, through its unique N-terminal proline-rich motif, interacts with the SH3 domain of Nck1, but not with other adaptor proteins composed only of SH domains, e.g. Grb2 and CrkII, and not with the adaptor protein Elmo1.	Proline	37-44	NCK adaptor protein 1	Rattus norvegicus	90-94
28955869-6	2016	Reintroduction of the proline-rich motif mutant of Dock8 in Dock8 siRNA-transfected Schwann cell precursors fails to restore their migratory abilities, whereas that of wild-type Dock8 does restore these abilities.	Proline	22-29	dedicator of cytokinesis 8	Rattus norvegicus	51-56
28955869-6	2016	Reintroduction of the proline-rich motif mutant of Dock8 in Dock8 siRNA-transfected Schwann cell precursors fails to restore their migratory abilities, whereas that of wild-type Dock8 does restore these abilities.	Proline	22-29	dedicator of cytokinesis 8	Rattus norvegicus	60-65
28955869-6	2016	Reintroduction of the proline-rich motif mutant of Dock8 in Dock8 siRNA-transfected Schwann cell precursors fails to restore their migratory abilities, whereas that of wild-type Dock8 does restore these abilities.	Proline	22-29	dedicator of cytokinesis 8	Rattus norvegicus	60-65
26910843-8	2016	By domain mapping of MST3, we determine that the proline-rich region of MST3 (353KDIPKRP359) interacts with the SH3 domain of VAV2.	Proline	49-56	serine/threonine kinase 24	Homo sapiens	21-25
26972007-4	2016	In normoxia, PHD2 hydroxylates the proline residues P2309 and P2316 in FLNA, leading to von Hippel-Lindau (VHL)-mediated ubiquitination and proteasomal degradation.	Proline	35-42	egl-9 family hypoxia inducible factor 1	Homo sapiens	13-17
26972007-4	2016	In normoxia, PHD2 hydroxylates the proline residues P2309 and P2316 in FLNA, leading to von Hippel-Lindau (VHL)-mediated ubiquitination and proteasomal degradation.	Proline	35-42	filamin A	Homo sapiens	71-75
26972007-4	2016	In normoxia, PHD2 hydroxylates the proline residues P2309 and P2316 in FLNA, leading to von Hippel-Lindau (VHL)-mediated ubiquitination and proteasomal degradation.	Proline	35-42	von Hippel-Lindau tumor suppressor	Homo sapiens	88-105
28031081-4	2016	Mutation analysis revealed a novel missense mutation in exon 7 of troponin I type 3 (TNNI3), resulting in substitution of serine (S) with proline (P) at amino acid position 150, which cosegregated with the disease in the family, which is predicted to be probably damaging using PolyPhen-2.	Proline	138-145	troponin I3, cardiac type	Homo sapiens	66-83
28031081-4	2016	Mutation analysis revealed a novel missense mutation in exon 7 of troponin I type 3 (TNNI3), resulting in substitution of serine (S) with proline (P) at amino acid position 150, which cosegregated with the disease in the family, which is predicted to be probably damaging using PolyPhen-2.	Proline	138-145	troponin I3, cardiac type	Homo sapiens	85-90
27081294-8	2016	Most importantly, the proline residue at position 49 of NRL is highly conserved from zebrafish to humans.	Proline	22-29	neural retina leucine zipper	Danio rerio	56-59
26797122-8	2016	Here we show by site-directed mutagenesis that multiple residues within the SF region (Pro(165), Tyr(166), Ser(167), and Asp(168)) of apoA-I are critical for both LCAT binding to HDL and LCAT catalytic efficiency.	Proline	87-90	apolipoprotein A1	Homo sapiens	134-140
26797122-8	2016	Here we show by site-directed mutagenesis that multiple residues within the SF region (Pro(165), Tyr(166), Ser(167), and Asp(168)) of apoA-I are critical for both LCAT binding to HDL and LCAT catalytic efficiency.	Proline	87-90	lecithin-cholesterol acyltransferase	Homo sapiens	163-167
26815332-2	2016	A recent experimental study has shown that the (147)GVIGIAQ(153) SOD1 C-terminal segment not only forms amyloid fibrils in isolation but also accelerates the aggregation of full-length SOD1, while substitution of isoleucine at site 149 by proline blocks its fibril formation.	Proline	239-246	superoxide dismutase 1	Homo sapiens	65-69
26815332-2	2016	A recent experimental study has shown that the (147)GVIGIAQ(153) SOD1 C-terminal segment not only forms amyloid fibrils in isolation but also accelerates the aggregation of full-length SOD1, while substitution of isoleucine at site 149 by proline blocks its fibril formation.	Proline	239-246	superoxide dismutase 1	Homo sapiens	185-189
26983498-7	2016	This hypoxia-induced TRPA1 sensitisation to H2O2 was inhibited by overexpressing a catalytically-inactive mutant of prolyl hydroxylase (PHD) 2 or in a TRPA1 proline mutant resistant to PHDs.	Proline	157-164	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	21-26
26983498-7	2016	This hypoxia-induced TRPA1 sensitisation to H2O2 was inhibited by overexpressing a catalytically-inactive mutant of prolyl hydroxylase (PHD) 2 or in a TRPA1 proline mutant resistant to PHDs.	Proline	157-164	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	151-156
26983498-9	2016	Our results suggest that transient hindlimb ischemia/reperfusion-evoked spontaneous licking, i.e. painful dysesthesia, is caused by ROS-evoked activation of TRPA1 sensitised by hypoxia through inhibiting PHD-mediated hydroxylation of a proline residue in TRPA1.	Proline	236-243	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	157-162
26980695-2	2016	Eya proteins contain a PST (Proline-Serine-Threonine)-rich transactivation domain, a threonine phosphatase motif (TPM), and a tyrosine protein phosphatase domain.	Proline	28-35	eyes absent	Drosophila melanogaster	0-3
26910843-8	2016	By domain mapping of MST3, we determine that the proline-rich region of MST3 (353KDIPKRP359) interacts with the SH3 domain of VAV2.	Proline	49-56	serine/threonine kinase 24	Homo sapiens	72-76
26910843-8	2016	By domain mapping of MST3, we determine that the proline-rich region of MST3 (353KDIPKRP359) interacts with the SH3 domain of VAV2.	Proline	49-56	vav guanine nucleotide exchange factor 2	Homo sapiens	126-130
26910843-9	2016	Mutation of the two proline residues in this domain significantly attenuates the interaction between MST3 and VAV2.	Proline	20-27	serine/threonine kinase 24	Homo sapiens	101-105
26910843-9	2016	Mutation of the two proline residues in this domain significantly attenuates the interaction between MST3 and VAV2.	Proline	20-27	vav guanine nucleotide exchange factor 2	Homo sapiens	110-114
26811873-6	2016	A metabolic pathway analysis also indicated that insulin affected the metabolism of alanine, aspartate and glutamate, as well as that of arginine and proline.	Proline	150-157	insulin	Homo sapiens	49-56
26637362-0	2016	SSR Markers Associated with Proline in Drought Tolerant Wheat Germplasm.	Proline	28-35	protein TPX2	Triticum aestivum	0-3
27111418-2	2016	We recently confirmed that angiopoietin-like protein 2 (ANGPTL2) is a potent angiogenic and proinflammatory factor in the cornea, and we have produced a single-stranded proline-modified short hairpin anti-ANGPTL2 RNA interference molecule that is carried in a lipid nanoparticle (ANGPTL2 Li-pshRNA) for topical application.	Proline	169-176	angiopoietin-like 2	Mus musculus	27-54
27111418-2	2016	We recently confirmed that angiopoietin-like protein 2 (ANGPTL2) is a potent angiogenic and proinflammatory factor in the cornea, and we have produced a single-stranded proline-modified short hairpin anti-ANGPTL2 RNA interference molecule that is carried in a lipid nanoparticle (ANGPTL2 Li-pshRNA) for topical application.	Proline	169-176	angiopoietin-like 2	Mus musculus	56-63
27111418-2	2016	We recently confirmed that angiopoietin-like protein 2 (ANGPTL2) is a potent angiogenic and proinflammatory factor in the cornea, and we have produced a single-stranded proline-modified short hairpin anti-ANGPTL2 RNA interference molecule that is carried in a lipid nanoparticle (ANGPTL2 Li-pshRNA) for topical application.	Proline	169-176	angiopoietin-like 2	Mus musculus	205-212
27111418-2	2016	We recently confirmed that angiopoietin-like protein 2 (ANGPTL2) is a potent angiogenic and proinflammatory factor in the cornea, and we have produced a single-stranded proline-modified short hairpin anti-ANGPTL2 RNA interference molecule that is carried in a lipid nanoparticle (ANGPTL2 Li-pshRNA) for topical application.	Proline	169-176	angiopoietin-like 2	Mus musculus	205-212
26804464-3	2016	Some small amino acids such as (R)-nipecotic acid are medium-to-strong binders of GAT1, but similar compounds, such as proline, are very weak binders.	Proline	119-126	solute carrier family 6 member 1	Homo sapiens	82-86
26938477-8	2016	In both birds and crocodilians, we have also identified a highly proline-enriched region at the N terminus of FoxP3, a region previously identified only in mammals.	Proline	65-72	forkhead box P3	Pseudopodoces humilis	110-115
26973686-4	2016	In spite of the well-characterized involvement of active eIF5A in the translation of proline repeat-rich proteins, its biological role has been recently elucidated only in mammals, and it is poorly described at the functional level in plants.	Proline	85-92	eukaryotic elongation factor 5A-1	Arabidopsis thaliana	57-62
26954508-3	2016	One such yeast protein, Nab3, is an 802 amino acid termination factor that contains an RNA recognition motif and a glutamine/proline rich domain adjacent to a region with structural similarity to a human hnRNP.	Proline	125-132	Nab3p	Saccharomyces cerevisiae S288C	24-28
26954508-8	2016	Importantly, full-length wildtype Nab3 also formed filaments with a characteristic cross-beta structure which was dependent upon the glutamine/proline-rich region.	Proline	143-150	Nab3p	Saccharomyces cerevisiae S288C	34-38
26957155-6	2016	We further applied it to examine the design of template molecules for aromatic meta-C-H activation in solutions and investigate solution conformations of the nonapeptide Bradykinin involving slow cis-trans isomerizations of three proline residues.	Proline	230-237	kininogen 1	Homo sapiens	170-180
26792489-0	2016	beta-amylase 1 (BAM1) degrades transitory starch to sustain proline biosynthesis during drought stress.	Proline	60-67	beta-amylase 1	Arabidopsis thaliana	0-14
26635356-4	2016	In agreement with previous reports, circulating human FGF21 was found to be cleaved primarily after three proline residues at positions 2, 4 and 171.	Proline	106-113	fibroblast growth factor 21	Homo sapiens	54-59
26635356-6	2016	Relative abundance of FGF21 proteins cleaved after Pro-2, Pro-4 and Pro-171 ranged from 16 to 30%, 10 to 25% and 10 to 34%, respectively.	Proline	51-54	fibroblast growth factor 21	Homo sapiens	22-27
26635356-6	2016	Relative abundance of FGF21 proteins cleaved after Pro-2, Pro-4 and Pro-171 ranged from 16 to 30%, 10 to 25% and 10 to 34%, respectively.	Proline	58-61	fibroblast growth factor 21	Homo sapiens	22-27
26635356-6	2016	Relative abundance of FGF21 proteins cleaved after Pro-2, Pro-4 and Pro-171 ranged from 16 to 30%, 10 to 25% and 10 to 34%, respectively.	Proline	58-61	fibroblast growth factor 21	Homo sapiens	22-27
26830682-7	2016	The estrogen receptor-beta and estrogen-response elements luciferase activity were significantly increased by proline in MCF-7 and MG63 cells.	Proline	110-117	estrogen receptor 2	Homo sapiens	4-26
26912818-5	2016	Glycine and proline only marginally stimulated the IL-8 production by IL-1beta-stimulated gingival fibroblast, whereas glycine dose-dependently inhibited the nitric oxide production by lipopolysaccharide-stimulated mouse macrophage-like RAW264.7 cells.	Proline	12-19	chemokine (C-X-C motif) ligand 15	Mus musculus	51-55
26912818-5	2016	Glycine and proline only marginally stimulated the IL-8 production by IL-1beta-stimulated gingival fibroblast, whereas glycine dose-dependently inhibited the nitric oxide production by lipopolysaccharide-stimulated mouse macrophage-like RAW264.7 cells.	Proline	12-19	interleukin 1 beta	Mus musculus	70-78
26884603-2	2016	Among various receptor kinases, ROOT HAIR SPECIFIC 10 (RHS10) belongs to a poorly known receptor kinase subfamily with a proline-rich extracellular domain.	Proline	121-128	root hair specific 10	Arabidopsis thaliana	32-53
26884603-2	2016	Among various receptor kinases, ROOT HAIR SPECIFIC 10 (RHS10) belongs to a poorly known receptor kinase subfamily with a proline-rich extracellular domain.	Proline	121-128	root hair specific 10	Arabidopsis thaliana	55-60
26884603-6	2016	RHS10 showed a strong association with the cell wall, most probably through its extracellular proline-rich domain (ECD).	Proline	94-101	root hair specific 10	Arabidopsis thaliana	0-5
26884603-7	2016	Deletion analysis of the ECD demonstrated that a minimal extracellular part, which includes a few proline residues, is required for RHS10-mediated root hair inhibition.	Proline	98-105	root hair specific 10	Arabidopsis thaliana	132-137
26773371-7	2016	However, the proline allele of the Ala1170Pro SNP was associated with a higher frequency of HER2 overexpression (56% versus 43%, p = 0.015).	Proline	13-20	erb-b2 receptor tyrosine kinase 2	Homo sapiens	92-96
26792489-0	2016	beta-amylase 1 (BAM1) degrades transitory starch to sustain proline biosynthesis during drought stress.	Proline	60-67	beta-amylase 1	Arabidopsis thaliana	16-20
26792489-9	2016	Moreover, bam1 mutants were impaired in proline accumulation and suffered from stronger lipid peroxidation, compared with both wild-type and bam3 plants.	Proline	40-47	beta-amylase 1	Arabidopsis thaliana	10-14
26792489-10	2016	Taken together, these data strongly suggest that carbon skeletons deriving from BAM1 diurnal degradation of transitory starch support the biosynthesis of proline required to face the osmotic stress.	Proline	154-161	beta-amylase 1	Arabidopsis thaliana	80-84
27164760-4	2016	We have produced a single-stranded proline-modified short hairpin anti-Angptl2 ribonucleric acid interference (RNAi) molecule that is carried in a lipid nanoparticle for topical application.	Proline	35-42	angiopoietin like 2	Homo sapiens	71-78
26735936-6	2016	In this work we performed a detailed analysis of the C-terminal domain sequence of SELK and discovered that it is characterized by many prolines, and four negatively and eleven positively charged residues, which are crucial for its biological activity.	Proline	136-144	selenoprotein K	Homo sapiens	83-87
26927806-7	2016	Coimmunoprecipitation and immunofluorescence analyses showed that ACOT8 Arg(45)-Phe(55) and Arg(86)-Pro(93) regions are involved in Nef association.	Proline	100-103	acyl-CoA thioesterase 8	Homo sapiens	66-71
27266252-2	2016	The increase in proline content caused by the salt stress was higher in the Col-0 plants than in the mutant jin1.	Proline	16-23	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	108-112
26927806-7	2016	Coimmunoprecipitation and immunofluorescence analyses showed that ACOT8 Arg(45)-Phe(55) and Arg(86)-Pro(93) regions are involved in Nef association.	Proline	100-103	S100 calcium binding protein B	Homo sapiens	132-135
26878238-9	2016	As for asparagine, this observation was linked to high levels of PYCR1, a key enzyme in proline production, suggesting a compensatory mechanism allowing tumour expansion.	Proline	88-95	pyrroline-5-carboxylate reductase 1	Homo sapiens	65-70
27000973-3	2016	Prolidase plays an important role in collagen metabolism by degrading imidodipeptides, in which proline or hydroxyproline residue is located at the C-terminal end.	Proline	96-103	peptidase D	Homo sapiens	0-9
26878238-10	2016	Indeed, PYCR1 is induced by shortage of proline precursors, and its suppression attenuated kidney cancer cell proliferation when proline was limiting.	Proline	40-47	pyrroline-5-carboxylate reductase 1	Homo sapiens	8-13
26878238-10	2016	Indeed, PYCR1 is induced by shortage of proline precursors, and its suppression attenuated kidney cancer cell proliferation when proline was limiting.	Proline	129-136	pyrroline-5-carboxylate reductase 1	Homo sapiens	8-13
26910425-10	2016	Simulations of the interaction recapitulated the increased distance between residues 166 and 262, and also provide a plausible mechanism for a twisting of the IkappaBalpha ARD induced by interactions of the IkappaBalpha proline-glutamate-serine-threonine-rich sequence with positively charged residues in the RelA NTD.	Proline	220-227	NFKB inhibitor alpha	Homo sapiens	159-171
26836284-6	2016	It has been demonstrated that a mutation of proline 135 located in the C-terminus of FGF1 results in (i) partial unfolding of FGF1, (ii) a decrease in FGF1"s ability to permeabilize bilayers composed of phosphatidylserine, and (iii) drastic inhibition of stress-induced FGF1 export.	Proline	44-51	fibroblast growth factor 1	Homo sapiens	85-89
26910425-10	2016	Simulations of the interaction recapitulated the increased distance between residues 166 and 262, and also provide a plausible mechanism for a twisting of the IkappaBalpha ARD induced by interactions of the IkappaBalpha proline-glutamate-serine-threonine-rich sequence with positively charged residues in the RelA NTD.	Proline	220-227	NFKB inhibitor alpha	Homo sapiens	207-219
26836284-6	2016	It has been demonstrated that a mutation of proline 135 located in the C-terminus of FGF1 results in (i) partial unfolding of FGF1, (ii) a decrease in FGF1"s ability to permeabilize bilayers composed of phosphatidylserine, and (iii) drastic inhibition of stress-induced FGF1 export.	Proline	44-51	fibroblast growth factor 1	Homo sapiens	126-130
26910425-10	2016	Simulations of the interaction recapitulated the increased distance between residues 166 and 262, and also provide a plausible mechanism for a twisting of the IkappaBalpha ARD induced by interactions of the IkappaBalpha proline-glutamate-serine-threonine-rich sequence with positively charged residues in the RelA NTD.	Proline	220-227	RELA proto-oncogene, NF-kB subunit	Homo sapiens	309-313
26836284-6	2016	It has been demonstrated that a mutation of proline 135 located in the C-terminus of FGF1 results in (i) partial unfolding of FGF1, (ii) a decrease in FGF1"s ability to permeabilize bilayers composed of phosphatidylserine, and (iii) drastic inhibition of stress-induced FGF1 export.	Proline	44-51	fibroblast growth factor 1	Homo sapiens	126-130
26836284-6	2016	It has been demonstrated that a mutation of proline 135 located in the C-terminus of FGF1 results in (i) partial unfolding of FGF1, (ii) a decrease in FGF1"s ability to permeabilize bilayers composed of phosphatidylserine, and (iii) drastic inhibition of stress-induced FGF1 export.	Proline	44-51	fibroblast growth factor 1	Homo sapiens	126-130
26892923-1	2016	BACKGROUND: Altered thyroid function and increased rates of N-terminal pro-B-Type natriuretic peptide (NT-pro-BNP) are highly prevalent in coronary artery disease (CAD) patients with heart failure, and are associated with unfavorable prognosis.	Proline	71-74	natriuretic peptide B	Homo sapiens	110-113
26909997-6	2016	TP53*72 showed genotypic distribution: in the control group, there was 16.10% homozygous Pro, and 42.44% heterozygous and 41.46% homozygous Arg; in the BC group, there was 15.43% homozygous Pro, and 42.55% heterozygous and 42.02% homozygous Arg.	Proline	89-92	tumor protein p53	Homo sapiens	0-4
26909997-6	2016	TP53*72 showed genotypic distribution: in the control group, there was 16.10% homozygous Pro, and 42.44% heterozygous and 41.46% homozygous Arg; in the BC group, there was 15.43% homozygous Pro, and 42.55% heterozygous and 42.02% homozygous Arg.	Proline	190-193	tumor protein p53	Homo sapiens	0-4
26853147-7	2016	Analysis of other TNFR sequences suggests proline-containing sequences as common motifs for receptor TM trimerization.	Proline	42-49	TNF receptor superfamily member 1A	Homo sapiens	18-22
26868272-7	2016	The physical association between the transmembrane/proline-rich domain (TMPRD) of SCOTIN and Domain-II of NS5A is essential for autophagosomal trafficking and NS5A degradation.	Proline	51-58	shisa family member 5	Homo sapiens	82-88
26877867-0	2016	Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion.	Proline	21-28	hematopoietically expressed homeobox	Homo sapiens	47-50
26877867-0	2016	Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion.	Proline	21-28	hematopoietically expressed homeobox	Homo sapiens	51-55
26952131-4	2016	Furthermore, the activities of caspase-3, caspase-8 and caspase-9 and the levels of ROS and cytochrome c were gradually decreased with increasing concentrations of Ala, Cit, Pro and Ala10Pro4Cit1 (0.175-1.400 mM) in the  OH-induced carp erythrocytes.	Proline	174-177	caspase 3	Homo sapiens	31-40
26952131-4	2016	Furthermore, the activities of caspase-3, caspase-8 and caspase-9 and the levels of ROS and cytochrome c were gradually decreased with increasing concentrations of Ala, Cit, Pro and Ala10Pro4Cit1 (0.175-1.400 mM) in the  OH-induced carp erythrocytes.	Proline	174-177	caspase 8	Homo sapiens	42-51
26952131-0	2016	Data in the activities of caspases and the levels of reactive oxygen species and cytochrome c in the  OH-induced fish erythrocytes treated with alanine, citrulline, proline and their combination.	Proline	165-172	caspase 8	Homo sapiens	26-34
26952131-4	2016	Furthermore, the activities of caspase-3, caspase-8 and caspase-9 and the levels of ROS and cytochrome c were gradually decreased with increasing concentrations of Ala, Cit, Pro and Ala10Pro4Cit1 (0.175-1.400 mM) in the  OH-induced carp erythrocytes.	Proline	174-177	caspase 9	Homo sapiens	56-65
26952131-0	2016	Data in the activities of caspases and the levels of reactive oxygen species and cytochrome c in the  OH-induced fish erythrocytes treated with alanine, citrulline, proline and their combination.	Proline	165-172	cytochrome c, somatic	Homo sapiens	81-93
26952131-1	2016	The present study explored the effects of alanine (Ala), citrulline (Cit), proline (Pro) and their combination (Ala10Pro4Cit1) on the activities of caspases and levels of reactive oxygen species (ROS) and cytochrome c in hydroxyl radicals ( OH)-induced carp erythrocytes.	Proline	75-82	caspase 8	Homo sapiens	148-156
26952131-1	2016	The present study explored the effects of alanine (Ala), citrulline (Cit), proline (Pro) and their combination (Ala10Pro4Cit1) on the activities of caspases and levels of reactive oxygen species (ROS) and cytochrome c in hydroxyl radicals ( OH)-induced carp erythrocytes.	Proline	84-87	caspase 8	Homo sapiens	148-156
26952131-3	2016	However, Ala, Cit, Pro and Ala10Pro4Cit1 effectively suppressed the  OH-induced increases in the activities of caspase-3, caspase-8 and caspase-9 and the levels of ROS and cytochrome c in carp erythrocytes.	Proline	19-22	caspase 3	Homo sapiens	111-120
26952131-3	2016	However, Ala, Cit, Pro and Ala10Pro4Cit1 effectively suppressed the  OH-induced increases in the activities of caspase-3, caspase-8 and caspase-9 and the levels of ROS and cytochrome c in carp erythrocytes.	Proline	19-22	caspase 8	Homo sapiens	122-131
26952131-3	2016	However, Ala, Cit, Pro and Ala10Pro4Cit1 effectively suppressed the  OH-induced increases in the activities of caspase-3, caspase-8 and caspase-9 and the levels of ROS and cytochrome c in carp erythrocytes.	Proline	19-22	caspase 9	Homo sapiens	136-145
26952131-3	2016	However, Ala, Cit, Pro and Ala10Pro4Cit1 effectively suppressed the  OH-induced increases in the activities of caspase-3, caspase-8 and caspase-9 and the levels of ROS and cytochrome c in carp erythrocytes.	Proline	19-22	cytochrome c, somatic	Homo sapiens	172-184
26952131-4	2016	Furthermore, the activities of caspase-3, caspase-8 and caspase-9 and the levels of ROS and cytochrome c were gradually decreased with increasing concentrations of Ala, Cit, Pro and Ala10Pro4Cit1 (0.175-1.400 mM) in the  OH-induced carp erythrocytes.	Proline	174-177	cytochrome c, somatic	Homo sapiens	92-104
26952131-6	2016	The 5% inhibitory doses (ID5) of Ala, Cit, Pro and Ala10Pro4Cit1 on the activities of caspase-8, caspase-9 and caspase-3 and levels of ROS and cytochrome c were estimated to be at their physiological concentrations in mammalian.	Proline	43-46	caspase 8	Homo sapiens	86-95
26859355-3	2016	Here we demonstrate that M phase-specific phosphorylation of the intramolecular interaction site within the proline-rich domain (PRD) of ALIX transforms cytosolic ALIX from closed to open conformation.	Proline	108-115	programmed cell death 6 interacting protein	Homo sapiens	137-141
26859355-3	2016	Here we demonstrate that M phase-specific phosphorylation of the intramolecular interaction site within the proline-rich domain (PRD) of ALIX transforms cytosolic ALIX from closed to open conformation.	Proline	108-115	programmed cell death 6 interacting protein	Homo sapiens	163-167
26909945-6	2016	Furthermore, overexpression of NaKR3 increased the expression of SOS1 and SOS3, but decreased the accumulation of salt-induced proline.	Proline	127-134	Chloroplast-targeted copper chaperone protein	Arabidopsis thaliana	31-36
26360328-9	2016	Peptides with Pro at position 2 showed higher affinity for B*51:01 and lower affinity for TAP than those with Ala at position 2.	Proline	14-17	nuclear RNA export factor 1	Homo sapiens	90-93
26780967-3	2016	In this study, we designed a novel nanodisc scaffold peptide (NSP) that has proline-punctuated bihelical amphipathic structure based on apoA-I mimetic peptides.	Proline	76-83	apolipoprotein A1	Homo sapiens	136-142
26792730-7	2016	Our data suggest that the Gly(219)-Pro-Tyr motif in the human CrkII linker region serves as the recognition and isomerization site of PPIases, and raise the possibility that CsA and FK506 might interfere with selected effector T cell functions via a CrkII-, but not CrkI-dependent mechanisms.	Proline	35-38	CRK proto-oncogene, adaptor protein	Homo sapiens	62-67
26792730-7	2016	Our data suggest that the Gly(219)-Pro-Tyr motif in the human CrkII linker region serves as the recognition and isomerization site of PPIases, and raise the possibility that CsA and FK506 might interfere with selected effector T cell functions via a CrkII-, but not CrkI-dependent mechanisms.	Proline	35-38	CRK proto-oncogene, adaptor protein	Homo sapiens	250-255
26642840-5	2016	The addition of osmolytes, such as glycine and proline, partially reactivated the Cd2+-mediated inactive PSCKM.	Proline	47-54	T-cell surface antigen CD2	Pelodiscus sinensis	82-85
26314333-2	2016	WWP1 is a HECT-type E3 ubiquitin protein ligase composed of 922 amino acids, which contains 4 tandem WW domains that interact with the proline-rich peptide motifs of target proteins.	Proline	135-142	WW domain containing E3 ubiquitin protein ligase 1	Gallus gallus	0-4
26690702-6	2016	Molecular analysis revealed that the extracellular Kringle domain is required for ROR1/ROR2 heterooligomerization and the cysteine-rich domain or intracellular proline-rich domain is required for Wnt5a-induced recruitment of GEFs to ROR1/ROR2.	Proline	160-167	wingless-type MMTV integration site family, member 5A	Mus musculus	196-201
26206088-1	2016	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase and its dysregulation is implicated in neurodegenerative diseases.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
26206088-1	2016	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase and its dysregulation is implicated in neurodegenerative diseases.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
27042481-11	2016	RESULTS: The frequency distributions of PPAR gamma genotypes were 80% for Pro/Pro and 20% for Pro/Ala in the study population.	Proline	74-77	peroxisome proliferator activated receptor gamma	Homo sapiens	40-50
27042481-11	2016	RESULTS: The frequency distributions of PPAR gamma genotypes were 80% for Pro/Pro and 20% for Pro/Ala in the study population.	Proline	78-81	peroxisome proliferator activated receptor gamma	Homo sapiens	40-50
27042481-11	2016	RESULTS: The frequency distributions of PPAR gamma genotypes were 80% for Pro/Pro and 20% for Pro/Ala in the study population.	Proline	78-81	peroxisome proliferator activated receptor gamma	Homo sapiens	40-50
26757928-4	2016	The functional consequence of HIF-1alpha methylation is the modulation of HIF-1alpha stability primarily in the nucleus, independent of its proline hydroxylation, during long-term hypoxic and normoxic conditions.	Proline	140-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-40
26718886-9	2016	The patients with a proline (Pro) polymorphism in SNP72 of TP53 showed significantly higher PrP-positive rates than those with arginine (Arg).	Proline	20-27	tumor protein p53	Homo sapiens	59-63
26718886-9	2016	The patients with a proline (Pro) polymorphism in SNP72 of TP53 showed significantly higher PrP-positive rates than those with arginine (Arg).	Proline	20-27	prion protein	Homo sapiens	92-95
26718886-9	2016	The patients with a proline (Pro) polymorphism in SNP72 of TP53 showed significantly higher PrP-positive rates than those with arginine (Arg).	Proline	29-32	tumor protein p53	Homo sapiens	59-63
26718886-9	2016	The patients with a proline (Pro) polymorphism in SNP72 of TP53 showed significantly higher PrP-positive rates than those with arginine (Arg).	Proline	29-32	prion protein	Homo sapiens	92-95
25943419-0	2016	High proline-related inhibition of serum prolidase enzyme activity in scleroderma.	Proline	5-12	peptidase D	Homo sapiens	41-50
26694855-5	2016	Several of the substitutions found in pufferfish IAPP are nonconservative including Ser to Pro, Asn to Thr, Ala to Tyr, and Leu to Tyr replacements, and several of these have not been reported in mammalian IAPP sequences.	Proline	91-94	islet amyloid polypeptide	Homo sapiens	49-53
26660717-0	2016	The proline-rich region of glyceraldehyde-3-phosphate dehydrogenase from human sperm may bind SH3 domains, as revealed by a bioinformatic study of low-complexity protein segments.	Proline	4-11	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	27-67
26660717-2	2016	This isoform is distinct from somatic GAPDH, not only in being specific for the testis but also because it contains an additional amino-terminal region that encodes a proline-rich motif that is known to bind to the fibrous sheath of the sperm tail.	Proline	167-174	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	38-43
26660717-3	2016	By conducting a large-scale sequence comparison on low-complexity sequences available in databases, we identified a strong similarity between the proline-rich motif from GAPDHS and the proline-rich sequence from Ena/vasodilator-stimulated phosphoprotein-like (EVL), which is known to bind an SH3 domain of dynamin-binding protein (DNMBP).	Proline	146-153	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Homo sapiens	170-176
26660717-3	2016	By conducting a large-scale sequence comparison on low-complexity sequences available in databases, we identified a strong similarity between the proline-rich motif from GAPDHS and the proline-rich sequence from Ena/vasodilator-stimulated phosphoprotein-like (EVL), which is known to bind an SH3 domain of dynamin-binding protein (DNMBP).	Proline	146-153	Enah/Vasp-like	Homo sapiens	212-258
26660717-3	2016	By conducting a large-scale sequence comparison on low-complexity sequences available in databases, we identified a strong similarity between the proline-rich motif from GAPDHS and the proline-rich sequence from Ena/vasodilator-stimulated phosphoprotein-like (EVL), which is known to bind an SH3 domain of dynamin-binding protein (DNMBP).	Proline	146-153	Enah/Vasp-like	Homo sapiens	260-263
26660717-3	2016	By conducting a large-scale sequence comparison on low-complexity sequences available in databases, we identified a strong similarity between the proline-rich motif from GAPDHS and the proline-rich sequence from Ena/vasodilator-stimulated phosphoprotein-like (EVL), which is known to bind an SH3 domain of dynamin-binding protein (DNMBP).	Proline	146-153	dynamin binding protein	Homo sapiens	306-329
26660717-3	2016	By conducting a large-scale sequence comparison on low-complexity sequences available in databases, we identified a strong similarity between the proline-rich motif from GAPDHS and the proline-rich sequence from Ena/vasodilator-stimulated phosphoprotein-like (EVL), which is known to bind an SH3 domain of dynamin-binding protein (DNMBP).	Proline	146-153	dynamin binding protein	Homo sapiens	331-336
26660717-3	2016	By conducting a large-scale sequence comparison on low-complexity sequences available in databases, we identified a strong similarity between the proline-rich motif from GAPDHS and the proline-rich sequence from Ena/vasodilator-stimulated phosphoprotein-like (EVL), which is known to bind an SH3 domain of dynamin-binding protein (DNMBP).	Proline	185-192	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Homo sapiens	170-176
26660717-3	2016	By conducting a large-scale sequence comparison on low-complexity sequences available in databases, we identified a strong similarity between the proline-rich motif from GAPDHS and the proline-rich sequence from Ena/vasodilator-stimulated phosphoprotein-like (EVL), which is known to bind an SH3 domain of dynamin-binding protein (DNMBP).	Proline	185-192	Enah/Vasp-like	Homo sapiens	212-258
26660717-3	2016	By conducting a large-scale sequence comparison on low-complexity sequences available in databases, we identified a strong similarity between the proline-rich motif from GAPDHS and the proline-rich sequence from Ena/vasodilator-stimulated phosphoprotein-like (EVL), which is known to bind an SH3 domain of dynamin-binding protein (DNMBP).	Proline	185-192	Enah/Vasp-like	Homo sapiens	260-263
26660717-3	2016	By conducting a large-scale sequence comparison on low-complexity sequences available in databases, we identified a strong similarity between the proline-rich motif from GAPDHS and the proline-rich sequence from Ena/vasodilator-stimulated phosphoprotein-like (EVL), which is known to bind an SH3 domain of dynamin-binding protein (DNMBP).	Proline	185-192	dynamin binding protein	Homo sapiens	306-329
26660717-3	2016	By conducting a large-scale sequence comparison on low-complexity sequences available in databases, we identified a strong similarity between the proline-rich motif from GAPDHS and the proline-rich sequence from Ena/vasodilator-stimulated phosphoprotein-like (EVL), which is known to bind an SH3 domain of dynamin-binding protein (DNMBP).	Proline	185-192	dynamin binding protein	Homo sapiens	331-336
26660717-4	2016	The putative binding partners of the proline-rich GAPDHS motif include SH3 domain-binding protein 4 (SH3BP4) and the IL2-inducible T-cell kinase/tyrosine-protein kinase ITK/TSK (ITK).	Proline	37-44	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Homo sapiens	50-56
26660717-4	2016	The putative binding partners of the proline-rich GAPDHS motif include SH3 domain-binding protein 4 (SH3BP4) and the IL2-inducible T-cell kinase/tyrosine-protein kinase ITK/TSK (ITK).	Proline	37-44	SH3-domain binding protein 4	Mus musculus	71-99
26660717-4	2016	The putative binding partners of the proline-rich GAPDHS motif include SH3 domain-binding protein 4 (SH3BP4) and the IL2-inducible T-cell kinase/tyrosine-protein kinase ITK/TSK (ITK).	Proline	37-44	SH3-domain binding protein 4	Mus musculus	101-107
26660717-4	2016	The putative binding partners of the proline-rich GAPDHS motif include SH3 domain-binding protein 4 (SH3BP4) and the IL2-inducible T-cell kinase/tyrosine-protein kinase ITK/TSK (ITK).	Proline	37-44	IL2 inducible T cell kinase	Mus musculus	117-176
26660717-4	2016	The putative binding partners of the proline-rich GAPDHS motif include SH3 domain-binding protein 4 (SH3BP4) and the IL2-inducible T-cell kinase/tyrosine-protein kinase ITK/TSK (ITK).	Proline	37-44	IL2 inducible T cell kinase	Mus musculus	169-172
26660717-7	2016	Furthermore, a mutation of one EVL proline to leucine is known to cause colorectal cancer, suggesting that mutation of homologous amino acid residue in the GAPDHS motif may be functionally deleterious.	Proline	35-42	Enah/Vasp-like	Homo sapiens	31-34
26660717-7	2016	Furthermore, a mutation of one EVL proline to leucine is known to cause colorectal cancer, suggesting that mutation of homologous amino acid residue in the GAPDHS motif may be functionally deleterious.	Proline	35-42	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Homo sapiens	156-162
26789760-5	2016	Proline residues are uniformly distributed along the polypeptide, except for the two alpha-helical regions, indicating that they play an active role in modulating the structural features of this CBP fragment.	Proline	0-7	CREB binding protein	Homo sapiens	195-198
27161247-10	2016	Many of the up- and downregulated PH1-PROs found in this study are also found in CKD, acute kidney injury, stone formers, and/or stone matrices.	Proline	38-42	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	34-37
26739646-3	2016	Moreover, Golgi-to-endosome trafficking was shown to be required for nuclear translocation of Gln3 upon a shift from rich medium to the poor nitrogen source proline, but not upon rapamycin treatment.	Proline	157-164	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	94-98
26771603-7	2016	Proline-rich regions, resembling arabinogalactan proteins point to a possible proline hydroxylation and subsequent O-glycosylation of AZI1.	Proline	0-7	azelaic acid induced 1	Arabidopsis thaliana	134-138
26771603-7	2016	Proline-rich regions, resembling arabinogalactan proteins point to a possible proline hydroxylation and subsequent O-glycosylation of AZI1.	Proline	78-85	azelaic acid induced 1	Arabidopsis thaliana	134-138
28955832-0	2016	A proline-type fullerene derivative inhibits adipogenesis by preventing PPARgamma activation.	Proline	2-9	peroxisome proliferator activated receptor gamma	Mus musculus	72-81
28955832-3	2016	One of the proline-type fullerene derivatives (P3) harboring three carboxy groups significantly inhibited lipid accumulation and the expression of adipocyte-specific genes, such as aP2, induced by the PPARgamma agonist rosiglitazone.	Proline	11-18	transcription factor AP-2, alpha	Mus musculus	181-184
28955832-3	2016	One of the proline-type fullerene derivatives (P3) harboring three carboxy groups significantly inhibited lipid accumulation and the expression of adipocyte-specific genes, such as aP2, induced by the PPARgamma agonist rosiglitazone.	Proline	11-18	peroxisome proliferator activated receptor gamma	Mus musculus	201-210
27928916-6	2016	It contained enhanced green fluorescent protein (EGFP) in the proline rich region (PRR) of Env.	Proline	62-69	melanoma antigen	Mus musculus	91-94
26851796-8	2016	Compare with the MIR group, three myocardial Cx43-pro and Cx43-Cq expression in the Ang II group were significantly decreased (P &lt; 0.05 and P &lt; 0.01), but DeltaCx43-pro and DeltaCx43-Cq were significant increased.	Proline	49-53	angiogenin	Oryctolagus cuniculus	84-87
27546702-1	2016	Prolidase (EC.3.4.13.9) or proline dipeptidase, is one of the unique enzyme capable of degrading dipeptides, in which a proline or hydroxyproline residue is located at the C-terminal position.	Proline	27-34	peptidase D	Homo sapiens	0-9
27889995-4	2016	Pin1 is the only proline isomerase that specifically recognizes certain Pro-directed Ser/Thr phosphorylation motifs.	Proline	17-24	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
27050729-0	2016	Proline Absorption and SGK1 Expression are Inhibited in Intestinal Tis7 Transgenic Mice.	Proline	0-7	interferon-related developmental regulator 1	Mus musculus	67-71
27050729-11	2016	CONCLUSIONS: Tis7 overexpression in enterocytes inhibits proline uptake, associated with decreased expression of activated SGK1 and reduced cell surface expression of SLC6A20.	Proline	57-64	interferon-related developmental regulator 1	Mus musculus	13-17
26358403-6	2016	The substitution of a proline at site 30 by an asparagine, an evolutionarily conserved functional residue in the scorpion alpha-KTx family, led to an increased activity on rKv1.2 and rKv1.3 but a decreased activity on the Shaker channel without changing the potency on rKv1.1, suggesting a key role of this site in species selectivity of scorpion toxins.	Proline	22-29	potassium voltage-gated channel subfamily A member 1	Rattus norvegicus	269-275
26601962-1	2016	Cyclin-dependent kinase 5 (CDK5) is a proline-directed serine/threonine kinase belonging to the family of cyclin-dependent kinases.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
26601962-1	2016	Cyclin-dependent kinase 5 (CDK5) is a proline-directed serine/threonine kinase belonging to the family of cyclin-dependent kinases.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
26489764-2	2016	SHB operates downstream of several tyrosine kinase receptors and assembles signaling complexes in response to receptor activation by interacting with other signaling proteins via its other domains (proline-rich, phosphotyrosine-binding and tyrosine-phosphorylation sites).	Proline	198-205	src homology 2 domain-containing transforming protein B	Mus musculus	0-3
26496921-5	2016	Although the interaction domain of PPP3CB is conserved among all isoforms of calcineurin A, ATOH8 selectively interacts with PPP3CB instead of PPP3CA, probably due to the unique proline-rich region present in the N-terminus of PPP3CB, which controls the specificity of its interaction partners.	Proline	178-185	atonal bHLH transcription factor 8	Homo sapiens	92-97
26590318-1	2016	Ligand binding to the TCR causes a conformational change at the CD3 subunits to expose the CD3epsilon cytoplasmic proline-rich sequence (PRS).	Proline	114-121	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	91-101
26676722-6	2016	Comparison of the infrared vibrations of the C=O, the N-H and the O-H groups of free L-proline with L-proline-M(2+) in both CS1 and CS2 complex structures indicated a considerable shift to lower frequency during complexation.	Proline	85-94	chorionic somatomammotropin hormone 1	Homo sapiens	124-127
26676722-6	2016	Comparison of the infrared vibrations of the C=O, the N-H and the O-H groups of free L-proline with L-proline-M(2+) in both CS1 and CS2 complex structures indicated a considerable shift to lower frequency during complexation.	Proline	85-94	chorionic somatomammotropin hormone 2	Homo sapiens	132-135
26676722-6	2016	Comparison of the infrared vibrations of the C=O, the N-H and the O-H groups of free L-proline with L-proline-M(2+) in both CS1 and CS2 complex structures indicated a considerable shift to lower frequency during complexation.	Proline	100-109	chorionic somatomammotropin hormone 1	Homo sapiens	124-127
26676722-6	2016	Comparison of the infrared vibrations of the C=O, the N-H and the O-H groups of free L-proline with L-proline-M(2+) in both CS1 and CS2 complex structures indicated a considerable shift to lower frequency during complexation.	Proline	100-109	chorionic somatomammotropin hormone 2	Homo sapiens	132-135
26139117-5	2016	Melittin analogues that have a proline residue substituted for an alanine, lysine or cysteine have been studied with both model membrane systems and living cells.	Proline	31-38	melittin	Apis mellifera	0-8
26547831-7	2016	A SHANK2 mutant lacking the proline-rich cortactin-binding motif (SHANK2-DeltaPRO) was unable to rescue these defects.	Proline	28-35	SH3 and multiple ankyrin repeat domains 2	Rattus norvegicus	2-8
26547831-7	2016	A SHANK2 mutant lacking the proline-rich cortactin-binding motif (SHANK2-DeltaPRO) was unable to rescue these defects.	Proline	28-35	cortactin	Rattus norvegicus	41-50
26547831-7	2016	A SHANK2 mutant lacking the proline-rich cortactin-binding motif (SHANK2-DeltaPRO) was unable to rescue these defects.	Proline	28-35	SH3 and multiple ankyrin repeat domains 2	Rattus norvegicus	66-72
25869255-3	2016	It was also previously demonstrated that the alpha-synuclein amyloid fibril formation is accelerated by mutations of proline residues to alanine in the acidic region.	Proline	117-124	synuclein alpha	Homo sapiens	45-60
25869255-4	2016	We performed replica exchange molecular dynamics simulations of the acidic and nonamyloid component (NAC) domains of the wild type and proline-to-alanine mutants of alpha-synuclein under various conditions.	Proline	135-142	synuclein alpha	Homo sapiens	101-104
25869255-4	2016	We performed replica exchange molecular dynamics simulations of the acidic and nonamyloid component (NAC) domains of the wild type and proline-to-alanine mutants of alpha-synuclein under various conditions.	Proline	135-142	synuclein alpha	Homo sapiens	165-180
27595037-2	2016	We show that expression of a mutant human huntingtin exon-1-GFP fusion construct results in nonspecific gene dysregulation that is significantly reduced by 50% due to coexpression of INT41, an intrabody specific for the proline-rich region of the huntingtin protein.	Proline	220-227	huntingtin	Homo sapiens	42-52
27595037-2	2016	We show that expression of a mutant human huntingtin exon-1-GFP fusion construct results in nonspecific gene dysregulation that is significantly reduced by 50% due to coexpression of INT41, an intrabody specific for the proline-rich region of the huntingtin protein.	Proline	220-227	mammary tumor integration site 41	Mus musculus	183-188
27595037-2	2016	We show that expression of a mutant human huntingtin exon-1-GFP fusion construct results in nonspecific gene dysregulation that is significantly reduced by 50% due to coexpression of INT41, an intrabody specific for the proline-rich region of the huntingtin protein.	Proline	220-227	huntingtin	Homo sapiens	247-257
26304112-9	2016	To characterize the proteolytic profile of FAPalpha, we investigated its specificity with proteome-derived peptide libraries and corroborated its preference for cleavage carboxy-terminal to proline residues.	Proline	190-197	fibroblast activation protein alpha	Homo sapiens	43-51
27581016-1	2016	Oxygen-dependent hydroxylation of critical proline residues, catalyzed by prolyl hydroxylase (PHD1-3) enzymes, is a crucial posttranslational modification (PTM) within the canonical hypoxia-inducible factor (HIF)-centric cellular oxygen-sensing pathway.	Proline	43-50	egl-9 family hypoxia inducible factor 2	Homo sapiens	94-100
29693967-6	2016	The complement profile(classical pathway activity, C3 and C4serum levels were slightly decreased,no signs of alternative pathway dysregulation)was indicative for classicalpathway activation and consumption.The genetic screening revealed a novelnon-synonymous variation in the CD46(MCP) gene in heterozygous form thatcauses a proline to leucine change atcodon 155 of the MCP (P155L).	Proline	325-332	CD46 molecule	Homo sapiens	276-280
26082265-8	2016	Physiological, biochemical and transcriptomic analyses showed that SlDREB2 enhanced plant tolerance to salinity by improvement of K(+) /Na(+) ratio, and proline and polyamines biosynthesis.	Proline	153-160	dehydration responsive element binding protein	Solanum lycopersicum	67-74
27795858-3	2016	Shank3 proteins are made of several domains-the Shank/ProSAP N-terminal (SPN) domain, ankyrin repeats, SH3 domain, PDZ domain, a proline-rich region, and the sterile alpha motif (SAM) domain.	Proline	129-136	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	0-6
27795858-3	2016	Shank3 proteins are made of several domains-the Shank/ProSAP N-terminal (SPN) domain, ankyrin repeats, SH3 domain, PDZ domain, a proline-rich region, and the sterile alpha motif (SAM) domain.	Proline	129-136	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	0-5
26785263-1	2016	BACKGROUND: In human papillomavirus (HPV)-induced carcinogenesis, the arginine (Arg) allele of the TP53 codon 72 polymorphism binds more efficiently to the HPV E6 oncoprotein than the proline (Pro) allele.	Proline	184-191	tumor protein p53	Homo sapiens	99-103
26785263-1	2016	BACKGROUND: In human papillomavirus (HPV)-induced carcinogenesis, the arginine (Arg) allele of the TP53 codon 72 polymorphism binds more efficiently to the HPV E6 oncoprotein than the proline (Pro) allele.	Proline	193-196	tumor protein p53	Homo sapiens	99-103
29693967-6	2016	The complement profile(classical pathway activity, C3 and C4serum levels were slightly decreased,no signs of alternative pathway dysregulation)was indicative for classicalpathway activation and consumption.The genetic screening revealed a novelnon-synonymous variation in the CD46(MCP) gene in heterozygous form thatcauses a proline to leucine change atcodon 155 of the MCP (P155L).	Proline	325-332	CD46 molecule	Homo sapiens	281-284
26613292-0	2015	Multiple Src Homology 3 Binding to the Ubiquitin Ligase Itch Conserved Proline-Rich Region.	Proline	71-78	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	9-12
26714015-5	2015	Frequency analysis of these phosphosites revealed a proline-rich motif signature downstream of BGLF4, indicating a broader substrate recognition for BGLF4 than its cellular ortholog cyclin-dependent kinase 1 (CDK1).	Proline	52-59	tegument serine/threonine protein kinase	Human gammaherpesvirus 4	95-100
26714015-5	2015	Frequency analysis of these phosphosites revealed a proline-rich motif signature downstream of BGLF4, indicating a broader substrate recognition for BGLF4 than its cellular ortholog cyclin-dependent kinase 1 (CDK1).	Proline	52-59	tegument serine/threonine protein kinase	Human gammaherpesvirus 4	149-154
26714015-5	2015	Frequency analysis of these phosphosites revealed a proline-rich motif signature downstream of BGLF4, indicating a broader substrate recognition for BGLF4 than its cellular ortholog cyclin-dependent kinase 1 (CDK1).	Proline	52-59	cyclin dependent kinase 1	Homo sapiens	182-207
26498358-4	2015	We show here that microtubule-associated tumor suppressor ATIP3 interacts with EB1 through direct binding of a non-canonical proline-rich motif.	Proline	125-132	microtubule associated protein RP/EB family member 1	Homo sapiens	79-82
26613292-0	2015	Multiple Src Homology 3 Binding to the Ubiquitin Ligase Itch Conserved Proline-Rich Region.	Proline	71-78	itchy E3 ubiquitin protein ligase	Homo sapiens	56-60
26613292-2	2015	In addition to these common domains, Itch also contains a conserved proline-rich region (PRR) allowing its interaction with Src homology 3 (SH3) domain-containing proteins.	Proline	68-75	itchy E3 ubiquitin protein ligase	Homo sapiens	37-41
26613292-2	2015	In addition to these common domains, Itch also contains a conserved proline-rich region (PRR) allowing its interaction with Src homology 3 (SH3) domain-containing proteins.	Proline	68-75	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	124-127
26508545-1	2015	Pin1 is a peptidyl prolyl isomerase that specifically catalyzes cis-trans isomerization of phosphorylated Thr/Ser-Pro peptide bonds in substrate proteins and peptides.	Proline	114-117	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
26782376-10	2015	Analysis of p53 gene polymorphisms showed a higher frequency for the genotype Arg/Pro (66%) and a lower frequency for the Arg/Arg (23%) and Pro/Pro (11%) genotypes.	Proline	82-85	tumor protein p53	Homo sapiens	12-15
26782376-10	2015	Analysis of p53 gene polymorphisms showed a higher frequency for the genotype Arg/Pro (66%) and a lower frequency for the Arg/Arg (23%) and Pro/Pro (11%) genotypes.	Proline	140-143	tumor protein p53	Homo sapiens	12-15
26782376-10	2015	Analysis of p53 gene polymorphisms showed a higher frequency for the genotype Arg/Pro (66%) and a lower frequency for the Arg/Arg (23%) and Pro/Pro (11%) genotypes.	Proline	140-143	tumor protein p53	Homo sapiens	12-15
26286913-12	2015	SH3BGRL3 interacts with phosphor-EGFR at Y1068, Y1086, and Y1173 through Grb2 by its proline-rich motif, and activates the Akt-associated signaling pathway.	Proline	85-92	SH3 domain binding glutamate rich protein like 3	Homo sapiens	0-8
26286913-12	2015	SH3BGRL3 interacts with phosphor-EGFR at Y1068, Y1086, and Y1173 through Grb2 by its proline-rich motif, and activates the Akt-associated signaling pathway.	Proline	85-92	epidermal growth factor receptor	Homo sapiens	33-37
26286913-12	2015	SH3BGRL3 interacts with phosphor-EGFR at Y1068, Y1086, and Y1173 through Grb2 by its proline-rich motif, and activates the Akt-associated signaling pathway.	Proline	85-92	growth factor receptor bound protein 2	Homo sapiens	73-77
26286913-12	2015	SH3BGRL3 interacts with phosphor-EGFR at Y1068, Y1086, and Y1173 through Grb2 by its proline-rich motif, and activates the Akt-associated signaling pathway.	Proline	85-92	AKT serine/threonine kinase 1	Homo sapiens	123-126
26661890-2	2015	They inhibit the activity of the angiotensin I-converting enzyme (ACE) and have a typical pyroglutamyl (Pyr)/proline-rich structure at the N- and C-terminus, respectively.	Proline	109-116	angiotensin I converting enzyme	Rattus norvegicus	66-69
26198764-11	2015	Among the novel potential susceptibility genes is PEPD, a gene involved in proline metabolism, which is associated with a Mendelian disorder characterized by developmental delay and cognitive deficits.	Proline	75-82	peptidase D	Homo sapiens	50-54
26545798-1	2015	Lim kinase (Limk), a proline/serine-rich sequence, can regulate the polymerization of the actin filaments by phosphorylating, and it is found to be highly involved in various human diseases.	Proline	21-28	LIM domain kinase 1	Homo sapiens	0-10
26508545-3	2015	We designed and synthesized a novel series of Pin1 inhibitors based on a glutamic acid or aspartic acid scaffold bearing an aromatic moiety to provide a hydrophobic surface and a cyclic aliphatic amine moiety with affinity for the proline-binding site of Pin1.	Proline	231-238	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	46-50
26545798-1	2015	Lim kinase (Limk), a proline/serine-rich sequence, can regulate the polymerization of the actin filaments by phosphorylating, and it is found to be highly involved in various human diseases.	Proline	21-28	LIM domain kinase 1	Homo sapiens	12-16
26878573-7	2015	The site-directed mutagenesis approach revealed the two GAPDS-specific proline residues, as well as three salt bridges, which seem to be the basis of the increased stability of this protein.	Proline	71-78	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	56-61
26720471-1	2015	PURPOSE: The beta subunit of the rod cyclic nucleotide gated channel B1 (CNGB1) contains a proline/glutamic acid-rich N-terminal domain (GARP), which is also present in rods as a non-membrane-bound protein (GARP1/2).	Proline	91-98	cyclic nucleotide gated channel beta 1	Mus musculus	73-78
26302489-16	2015	A motif of histidine, proline, and aspartic acid in the J domain of DNAJB6a was required for its tumor-suppressive effects and signaling via AKT1.	Proline	22-29	AKT serine/threonine kinase 1	Homo sapiens	141-145
26453918-4	2015	MIF has an unusual nucleophilic N-terminal proline with catalytic tautomerase activity.	Proline	43-50	macrophage migration inhibitory factor	Homo sapiens	0-3
26453918-7	2015	We hypothesized that MPO-derived oxidants would oxidize the N-terminal proline of MIF and alter its biological activity.	Proline	71-78	myeloperoxidase	Homo sapiens	21-24
26453918-7	2015	We hypothesized that MPO-derived oxidants would oxidize the N-terminal proline of MIF and alter its biological activity.	Proline	71-78	macrophage migration inhibitory factor	Homo sapiens	82-85
26453918-9	2015	Imine formation and carbamylation was observed on the N-terminal proline in response to MPO-dependent generation of hypochlorous and hypothiocyanous acid, respectively.	Proline	65-72	myeloperoxidase	Homo sapiens	88-91
26210809-1	2015	The kaeA(KAE1) (suDpro) gene, which was identified in Aspergillus nidulans as a suppressor of proline auxotrophic mutations, encodes the orthologue of Saccharomyces cerevisiae Kae1p, a member of the evolutionarily conserved KEOPS/EKC (Kinase, Endopeptidase and Other Proteins of Small size/Endopeptidase-like and Kinase associated to transcribed Chromatin) complex.	Proline	94-101	tRNA N6-adenosine threonylcarbamoyltransferase	Saccharomyces cerevisiae S288C	9-13
26210809-1	2015	The kaeA(KAE1) (suDpro) gene, which was identified in Aspergillus nidulans as a suppressor of proline auxotrophic mutations, encodes the orthologue of Saccharomyces cerevisiae Kae1p, a member of the evolutionarily conserved KEOPS/EKC (Kinase, Endopeptidase and Other Proteins of Small size/Endopeptidase-like and Kinase associated to transcribed Chromatin) complex.	Proline	94-101	tRNA N6-adenosine threonylcarbamoyltransferase	Saccharomyces cerevisiae S288C	176-181
26720471-1	2015	PURPOSE: The beta subunit of the rod cyclic nucleotide gated channel B1 (CNGB1) contains a proline/glutamic acid-rich N-terminal domain (GARP), which is also present in rods as a non-membrane-bound protein (GARP1/2).	Proline	91-98	leucine rich repeat containing 32	Mus musculus	137-141
26302999-0	2015	Collagen-Derived N-Acetylated Proline-Glycine-Proline in Intervertebral Discs Modulates CXCR1/2 Expression and Activation in Cartilage Endplate Stem Cells to Induce Migration and Differentiation Toward a Pro-Inflammatory Phenotype.	Proline	30-37	C-X-C motif chemokine receptor 1	Homo sapiens	88-93
26485222-2	2015	OBJECTIVE: Structure-function analysis of a missense mutation in the GH-1 gene converting codon 76 from leucine (L) to proline (P) yielding a mutant GH-L76P peptide.	Proline	119-126	growth hormone 1	Homo sapiens	69-73
25666758-3	2015	Genetic variants at chromosome 22q11.2, located in and near PRODH (proline dehydrogenase), were associated with L-proline in plasma (beta=0.29; P=6.38 x 10(-10)).	Proline	112-121	proline dehydrogenase 1	Homo sapiens	60-65
25666758-3	2015	Genetic variants at chromosome 22q11.2, located in and near PRODH (proline dehydrogenase), were associated with L-proline in plasma (beta=0.29; P=6.38 x 10(-10)).	Proline	112-121	proline dehydrogenase 1	Homo sapiens	67-88
25666758-4	2015	The missense variant rs17279437 in the proline transporter SLC6A20 was associated with L-proline in CSF (beta=0.28; P=9.68 x 10(-9)).	Proline	87-96	solute carrier family 6 member 20	Homo sapiens	59-66
26463018-5	2015	TAS2R38 genotyping demonstrated that this subject was a homozygous carrier of the proline-alanine-valine taster haplotype.	Proline	82-89	taste 2 receptor member 38	Homo sapiens	0-7
26422362-4	2015	Target region capture sequencing yielded a novel missense mutation at codon 123 (P123L) which is a heterozygous C to T point mutation at position 368 (c.368C>T) in exon 5 of the presenilin 2 leading to a proline-to-leucine substitution.	Proline	204-211	presenilin 2	Homo sapiens	178-190
25258030-2	2015	A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes.	Proline	137-144	neuropeptide Y	Homo sapiens	70-73
26302999-0	2015	Collagen-Derived N-Acetylated Proline-Glycine-Proline in Intervertebral Discs Modulates CXCR1/2 Expression and Activation in Cartilage Endplate Stem Cells to Induce Migration and Differentiation Toward a Pro-Inflammatory Phenotype.	Proline	46-53	C-X-C motif chemokine receptor 1	Homo sapiens	88-93
26655473-1	2015	Hierarchic phosphorylation and concomitant Pin1-mediated proline isomerization of the oncoprotein c-Myc controls its cellular stability and activity.	Proline	57-64	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	43-47
26655473-1	2015	Hierarchic phosphorylation and concomitant Pin1-mediated proline isomerization of the oncoprotein c-Myc controls its cellular stability and activity.	Proline	57-64	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	98-103
28955804-7	2016	Mutation of cysteine-32 but not cysteine-35 in the Trp-Cys32-Gly-Pro-Cys35 motif eliminated the binding of Trx1 with S-sulfhydrated proteins and abolished the S-desulfhydrating effect of Trx1.	Proline	65-68	thioredoxin	Homo sapiens	107-111
26364624-6	2015	Sequencing of the RPE65 gene revealed 2 mutations: (1) a previously identified disease-causing exonic leucine-to-proline mutation (L408P) and (2) a novel single point mutation in intron 3 (IVS3-11) resulting in an A&gt;G change.	Proline	113-120	retinoid isomerohydrolase RPE65	Homo sapiens	18-23
26188904-0	2015	TLR2 22 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene: a case-control study from four ethnic groups of North Eastern region of India.	Proline	89-96	toll like receptor 2	Homo sapiens	0-4
26188904-0	2015	TLR2 22 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene: a case-control study from four ethnic groups of North Eastern region of India.	Proline	89-96	tumor protein p53	Homo sapiens	119-123
26188904-8	2015	In the present study it was found that females carrying 22 base-pair deletion in the promoter region of their TLR2 gene had two times (AOR= 2.18, 95 % CI 1.13-4.21, p=0.019 in dominant model; AOR= 2.17, 95 % CI 1.09-4.34, p=0.027 in co-dominant model) increased risk of BC whwn they also carry proline allele at codon 72 of their TP53 gene.	Proline	294-301	toll like receptor 2	Homo sapiens	110-114
28955804-7	2016	Mutation of cysteine-32 but not cysteine-35 in the Trp-Cys32-Gly-Pro-Cys35 motif eliminated the binding of Trx1 with S-sulfhydrated proteins and abolished the S-desulfhydrating effect of Trx1.	Proline	65-68	thioredoxin	Homo sapiens	187-191
26553976-3	2015	The adaptor protein Nck has three SRC-homology 3 (SH3) domains that bind multiple proline-rich segments in the actin regulatory protein neuronal Wiskott-Aldrich syndrome protein (N-WASP) and an SH2 domain that binds to multiple phosphotyrosine sites in the adhesion protein nephrin, leading to phase separation.	Proline	82-89	NCK adaptor protein 1	Homo sapiens	20-23
26553976-3	2015	The adaptor protein Nck has three SRC-homology 3 (SH3) domains that bind multiple proline-rich segments in the actin regulatory protein neuronal Wiskott-Aldrich syndrome protein (N-WASP) and an SH2 domain that binds to multiple phosphotyrosine sites in the adhesion protein nephrin, leading to phase separation.	Proline	82-89	WASP like actin nucleation promoting factor	Homo sapiens	179-185
26598224-2	2015	Previously we showed that MYC increases proline biosynthesis (PB) from glutamine.	Proline	40-47	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	26-29
26598224-5	2015	Addition of Delta(1)-pyrroline-5-carboxylate (P5C) or proline reverses the effects of P5C synthase knockdown but not P5C reductases knockdown.	Proline	54-61	pyrroline-5-carboxylate reductase 1	Homo sapiens	86-89
26598224-5	2015	Addition of Delta(1)-pyrroline-5-carboxylate (P5C) or proline reverses the effects of P5C synthase knockdown but not P5C reductases knockdown.	Proline	54-61	pyrroline-5-carboxylate reductase 1	Homo sapiens	86-89
26598224-6	2015	Importantly, the reversal effect of proline was blocked by concomitant proline dehydrogenase/oxidase (PRODH/POX) knockdown.	Proline	36-43	proline dehydrogenase 1	Homo sapiens	102-107
26598224-6	2015	Importantly, the reversal effect of proline was blocked by concomitant proline dehydrogenase/oxidase (PRODH/POX) knockdown.	Proline	36-43	proline dehydrogenase 1	Homo sapiens	108-111
26599013-6	2015	The other way round, DEGs involved in processes such as oxidation, photosynthesis, and starch, proline, ethylene, and salicylic acid metabolism were clearly co-expressed with the MAPKKK genes.	Proline	95-102	Mitogen-activated protein kinase kinase kinase 3	Zea mays	179-185
26600509-4	2015	C/T single nucleotide polymorphisms were detected at the site of 1285 bp of the HIF-1alpha exon, from a proline to a serine (Pro582Ser).	Proline	104-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
26543159-5	2015	Histone peptide profiling revealed that human NRMT1 is highly selective to human CENP-A and fruit fly H2B, which share a common "Xaa-Pro-Lys/Arg" motif.	Proline	133-136	N-terminal Xaa-Pro-Lys N-methyltransferase 1	Homo sapiens	46-51
26310625-6	2015	The FBXO7 aggregation and toxicity can be alleviated by Proline, glutathione (GSH) and coenzyme Q10, whereas deleterious FBXO7 aggregation in mitochondria can be aggravated by prohibitin 1 (PHB1), a mitochondrial protease inhibitor.	Proline	56-63	F-box protein 7	Homo sapiens	4-9
26543159-5	2015	Histone peptide profiling revealed that human NRMT1 is highly selective to human CENP-A and fruit fly H2B, which share a common "Xaa-Pro-Lys/Arg" motif.	Proline	133-136	centromere protein A	Homo sapiens	81-87
26555036-7	2015	RESULTS: The close proximity of Arg/Lys amino acids and a proline two residues N-terminal to the phosphorylated residue both improve recognition of the substrate by CDK5.	Proline	58-65	cyclin dependent kinase 5	Homo sapiens	165-169
26438723-0	2015	Alzheimer"s disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction.	Proline	28-35	presenilin 1	Mus musculus	58-70
26438723-2	2015	We have addressed this question by comparing mutational patterns that are linked to the manifestation of distinct neurodegenerative disorders and identified similar neurodegeneration-linked proline substitutions in the prion protein and in presenilin 1 that underlie the development of a prion disorder and of familial Alzheimer"s disease (fAD), respectively.	Proline	190-197	presenilin 1	Mus musculus	240-252
26409900-2	2015	The multidomain arrangement of HPRG comprises two modules at the N-terminus that are homologous to cystatin but void of cysteine proteinase inhibitor function, and a second half consisting of a histidine-proline-rich region (HPRR) located between two proline-rich regions (PRR1 and PRR2), and a C-terminus domain.	Proline	204-211	histidine rich glycoprotein	Homo sapiens	31-35
26545118-3	2015	In this subfamily, transmembrane helices (TM) 2 and 5 are characterized by the absence of proline compared to most receptors, raising the question of the structural conformation of these helices.	Proline	90-97	tropomyosin 3	Homo sapiens	19-53
26409900-2	2015	The multidomain arrangement of HPRG comprises two modules at the N-terminus that are homologous to cystatin but void of cysteine proteinase inhibitor function, and a second half consisting of a histidine-proline-rich region (HPRR) located between two proline-rich regions (PRR1 and PRR2), and a C-terminus domain.	Proline	251-258	histidine rich glycoprotein	Homo sapiens	31-35
26593415-3	2015	We synthesized an N-palmitoylated peptide Palm-Val-[Lys-Asn-Lys-Asn-Leu-His-Ser-Pro-(Nle)-Tyr-Phe-Phe71-82]-amide-Palm-Val-(71-82) structurally corresponding to cytoplasmic loop 1 of melanocortin 4 receptor (M4R).	Proline	80-83	melanocortin 4 receptor	Rattus norvegicus	183-206
26593415-3	2015	We synthesized an N-palmitoylated peptide Palm-Val-[Lys-Asn-Lys-Asn-Leu-His-Ser-Pro-(Nle)-Tyr-Phe-Phe71-82]-amide-Palm-Val-(71-82) structurally corresponding to cytoplasmic loop 1 of melanocortin 4 receptor (M4R).	Proline	80-83	melanocortin 4 receptor	Rattus norvegicus	208-211
26261268-8	2015	The single base pair mutations disrupted NYC1 function by three distinct mechanisms, one by producing a termination codon, the second by interfering with correct intron splicing and the third by replacing a highly conserved proline with a non-equivalent serine residue.	Proline	224-231	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	41-45
26385979-7	2015	Direct genomic sequencing of all Slco1a6 exons identified a nonsynonymous coding SNP that converts a highly conserved proline residue at amino acid position 564 to serine.	Proline	118-125	solute carrier organic anion transporter family, member 1a6	Mus musculus	33-40
26036470-6	2015	In the analysis of the expression of anchoring subunits of AChE in P2Y1R (-/-) mice, the proline-rich membrane anchor (PRiMA) subunit was reduced by 60 %; while the collagen tail (ColQ) subunit was reduced by 50 %.	Proline	89-96	acetylcholinesterase	Mus musculus	59-63
26036470-6	2015	In the analysis of the expression of anchoring subunits of AChE in P2Y1R (-/-) mice, the proline-rich membrane anchor (PRiMA) subunit was reduced by 60 %; while the collagen tail (ColQ) subunit was reduced by 50 %.	Proline	89-96	proline rich membrane anchor 1	Mus musculus	119-124
26330555-1	2015	Proline oxidase (POX) catalytically converts proline to pyrroline-5-carboxylate.	Proline	45-52	proline dehydrogenase 1	Homo sapiens	0-15
26311872-5	2015	PEMV virions and a peptide comprised of PEMV CP fused to a proline-rich hinge (-P-) and green fluorescent protein (CP-P-GFP) specifically bound to APN.	Proline	59-66	alanyl aminopeptidase, membrane	Homo sapiens	147-150
26354418-5	2015	COBL localizes to the base of BB microvilli via a mechanism that requires its proline-rich N-terminus.	Proline	78-85	cordon-bleu WH2 repeat protein	Homo sapiens	0-4
26367176-5	2015	We previously proposed a toxic dimer model of Abeta with turn structure at positions 22 and 23 using solid-state NMR and systematic proline replacement.	Proline	132-139	amyloid beta precursor protein	Homo sapiens	46-51
26539205-8	2015	All these results indicate that AtLTI30 is a positive regulator of plant drought stress resistance, partially through the modulation of ABA sensitivity, H2O2 and proline accumulation.	Proline	162-169	dehydrin family protein	Arabidopsis thaliana	32-39
26386179-14	2015	Even more interesting, we demonstrated that PAR3 binds preferentially to the full-length cytoplasmic tail of ApoER2 corresponding to the splice-variant containing the exon 19 that encodes a proline-rich insert and that ApoER2 was required for SC migration.	Proline	190-197	pulmonary adenoma resistance 3	Mus musculus	44-48
26386179-14	2015	Even more interesting, we demonstrated that PAR3 binds preferentially to the full-length cytoplasmic tail of ApoER2 corresponding to the splice-variant containing the exon 19 that encodes a proline-rich insert and that ApoER2 was required for SC migration.	Proline	190-197	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	Mus musculus	109-115
26514776-4	2015	On the contrary, proline appears to control cell division in early stages of postembryonic root development, as shown by the expression of the G2/M-specific CYCLINB1;1 (CYCB1;1) gene.	Proline	17-24	CYCLIN B1;1	Arabidopsis thaliana	157-167
26514776-4	2015	On the contrary, proline appears to control cell division in early stages of postembryonic root development, as shown by the expression of the G2/M-specific CYCLINB1;1 (CYCB1;1) gene.	Proline	17-24	CYCLIN B1;1	Arabidopsis thaliana	169-176
26502977-9	2015	In contrast, soluble tau phosphorylated in the proline rich region was cleared faster than total soluble tau.	Proline	47-54	microtubule associated protein tau	Homo sapiens	21-24
26502977-15	2015	Turnover was significantly delayed for insoluble tau whereas it was accelerated for soluble tau phosphorylated in the proline rich region.	Proline	118-125	microtubule associated protein tau	Homo sapiens	92-95
26539205-7	2015	Moreover, manipulation of AtLTI30 expression positively regulated the activities of catalases (CATs) and endogenous proline content, as a result, negatively regulated drought stress-triggered hydrogen peroxide (H2O2) accumulation.	Proline	116-123	dehydrin family protein	Arabidopsis thaliana	26-33
26330555-1	2015	Proline oxidase (POX) catalytically converts proline to pyrroline-5-carboxylate.	Proline	45-52	proline dehydrogenase 1	Homo sapiens	17-20
26332362-3	2015	We determine the proline isomeric preference of three CTD phosphatases: Ssu72 as cis-proline specific, Scp1 and Fcp1 as strongly trans-preferred.	Proline	17-24	SSU72 homolog, RNA polymerase II CTD phosphatase	Homo sapiens	72-77
26332362-3	2015	We determine the proline isomeric preference of three CTD phosphatases: Ssu72 as cis-proline specific, Scp1 and Fcp1 as strongly trans-preferred.	Proline	17-24	CTD small phosphatase 1	Homo sapiens	103-107
26332362-3	2015	We determine the proline isomeric preference of three CTD phosphatases: Ssu72 as cis-proline specific, Scp1 and Fcp1 as strongly trans-preferred.	Proline	17-24	FCP1	Homo sapiens	112-116
26332362-4	2015	Due to this inherent characteristic, these phosphatases respond differently to enzymes that catalyze the isomerization of proline, like Ess1/Pin1.	Proline	122-129	transforming growth factor beta receptor 1	Homo sapiens	136-140
26332362-4	2015	Due to this inherent characteristic, these phosphatases respond differently to enzymes that catalyze the isomerization of proline, like Ess1/Pin1.	Proline	122-129	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	141-145
26472563-3	2015	Proline, glutamic acid, leucine rich protein 1 (PELP1) is a novel steroidal receptor co-regulator, functioning as an oncogene and its expression is maintained in estrogen receptor (ER) negative breast cancers.	Proline	0-7	proline, glutamate and leucine rich protein 1	Homo sapiens	48-53
26472563-3	2015	Proline, glutamic acid, leucine rich protein 1 (PELP1) is a novel steroidal receptor co-regulator, functioning as an oncogene and its expression is maintained in estrogen receptor (ER) negative breast cancers.	Proline	0-7	estrogen receptor 1	Homo sapiens	162-179
26472563-3	2015	Proline, glutamic acid, leucine rich protein 1 (PELP1) is a novel steroidal receptor co-regulator, functioning as an oncogene and its expression is maintained in estrogen receptor (ER) negative breast cancers.	Proline	0-7	estrogen receptor 1	Homo sapiens	181-183
26276391-3	2015	The association between Pin1 and the AMPK gamma1 subunit is mediated by the WW domain of Pin1 and the Thr(211)-Pro-containing motif located in the CBS domain of the gamma1 subunit.	Proline	111-114	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	24-28
26406962-3	2015	The WW domain of human Pin1 can recognize the phosphoserine/phosphothreonine-proline (pS/pT-P) motifs, while its PPIase domain catalyzes the cis/trans isomerization of prolyl bonds to regulate the cell cycle.	Proline	77-84	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	23-27
26406962-5	2015	On the basis of the ligand Myt1-T412 [PPA(pT)PP], we synthesized several phosphopeptides in which the proline residue in the pT-P motif was replaced with various 4-substituted proline derivatives.	Proline	102-109	myelin transcription factor 1	Homo sapiens	27-31
26276391-3	2015	The association between Pin1 and the AMPK gamma1 subunit is mediated by the WW domain of Pin1 and the Thr(211)-Pro-containing motif located in the CBS domain of the gamma1 subunit.	Proline	111-114	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	Mus musculus	37-48
26079855-6	2015	Surprisingly, PxxPxR motifs from the proline rich region of SOS1 or CBL were neither necessary nor sufficient for the in vitro or in vivo interaction with full-length GRB2.	Proline	37-44	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	60-64
25766872-3	2015	SCOPE OF REVIEW: We have evaluated interactions between Pin1 and the regulatory kinome and proline-dependent phosphoproteome taking into consideration findings from targeted studies as well as data that has emerged from systematic phosphoproteomic workflows and from curated protein interaction databases.	Proline	91-98	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	56-60
26316468-3	2015	We designed our multifunctional ligands based on the well-known second generation bradykinin 2 receptor antagonist Hoe 140 (DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg-OH) and the opioid enkephalin analogues Tyr-DAla-Phe, Tyr-DAla-Gly-Phe and Tyr-Pro-Phe.	Proline	133-136	proenkephalin	Rattus norvegicus	185-195
25924982-0	2015	Proline-poor hydrophobic domains modulate the assembly and material properties of polymeric elastin.	Proline	0-7	elastin	Homo sapiens	92-99
25924982-4	2015	However, the native sequence of hydrophobic elastin domain 30 is uncharacteristically proline-poor and, as an isolated polypeptide, is susceptible to formation of amyloid-like structures comprised of stacked beta-sheet.	Proline	86-93	elastin	Homo sapiens	44-51
26722484-3	2015	We found that phosphorylated Akt and proline-rich Akt substrate 40 levels were significantly increased in the RV compared with the LV in rats but only had an increased trend in mice.	Proline	37-44	AKT serine/threonine kinase 1	Rattus norvegicus	50-53
26428302-12	2015	Structural studies showed that a linker region between the proline-rich regions and the Src homology 3 (SH3) domain of Abi-1 is crucial for its interaction with c-Abl and c-Abl-mediated phosphorylation of WAVE2.	Proline	59-66	abl interactor 1	Mus musculus	119-124
26428302-12	2015	Structural studies showed that a linker region between the proline-rich regions and the Src homology 3 (SH3) domain of Abi-1 is crucial for its interaction with c-Abl and c-Abl-mediated phosphorylation of WAVE2.	Proline	59-66	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	161-166
26428302-12	2015	Structural studies showed that a linker region between the proline-rich regions and the Src homology 3 (SH3) domain of Abi-1 is crucial for its interaction with c-Abl and c-Abl-mediated phosphorylation of WAVE2.	Proline	59-66	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	171-176
26428302-12	2015	Structural studies showed that a linker region between the proline-rich regions and the Src homology 3 (SH3) domain of Abi-1 is crucial for its interaction with c-Abl and c-Abl-mediated phosphorylation of WAVE2.	Proline	59-66	WASP family, member 2	Mus musculus	205-210
25841889-0	2015	Neurotrophic Activity of Cultured Cell Line U87 is Up-Regulated by Proline-Rich Polypeptide Complex and Its Constituent Nonapeptide.	Proline	67-74	small nucleolar RNA, C/D box 87	Homo sapiens	44-47
26058814-2	2015	Numb is alternatively spliced, with one isoform containing a long proline-rich region (PRR(L) ) compared to the other with a short PRR (PRR(S) ).	Proline	66-73	NUMB endocytic adaptor protein	Homo sapiens	0-4
26441830-11	2015	However, introduction of a structure-disturbing double-proline mutant LHCGR-Q303P/E305P within the exon10-helix has, in contrast to exon10-deletion, no impact on hLH, but only on hCG signaling.	Proline	55-62	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	70-75
26304991-7	2015	Part of the PSTPIP2 inhibitory function is mediated by protein tyrosine phosphatases from the proline-, glutamic acid-, serine- and threonine-rich (PEST) family, which are known to interact with the central part of this protein, but other regions of PSTPIP2 not required for PEST-family phosphatase binding were also shown to be indispensable for PSTPIP2 function.	Proline	94-101	proline-serine-threonine phosphatase interacting protein 2	Homo sapiens	12-19
26304991-7	2015	Part of the PSTPIP2 inhibitory function is mediated by protein tyrosine phosphatases from the proline-, glutamic acid-, serine- and threonine-rich (PEST) family, which are known to interact with the central part of this protein, but other regions of PSTPIP2 not required for PEST-family phosphatase binding were also shown to be indispensable for PSTPIP2 function.	Proline	94-101	proline-serine-threonine phosphatase interacting protein 2	Homo sapiens	250-257
26304991-7	2015	Part of the PSTPIP2 inhibitory function is mediated by protein tyrosine phosphatases from the proline-, glutamic acid-, serine- and threonine-rich (PEST) family, which are known to interact with the central part of this protein, but other regions of PSTPIP2 not required for PEST-family phosphatase binding were also shown to be indispensable for PSTPIP2 function.	Proline	94-101	proline-serine-threonine phosphatase interacting protein 2	Homo sapiens	250-257
26139345-0	2015	Extended conformation of the proline-rich domain of human aryl hydrocarbon receptor-interacting protein-like 1: implications for retina disease.	Proline	29-36	aryl hydrocarbon receptor interacting protein like 1	Homo sapiens	58-110
26139345-1	2015	Mutations in the primate-specific proline-rich domain (PRD) of aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) are thought to cause Leber congenital amaurosis or dominant cone-rod dystrophy.	Proline	34-41	aryl hydrocarbon receptor interacting protein like 1	Homo sapiens	63-115
26139345-1	2015	Mutations in the primate-specific proline-rich domain (PRD) of aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) are thought to cause Leber congenital amaurosis or dominant cone-rod dystrophy.	Proline	34-41	aryl hydrocarbon receptor interacting protein like 1	Homo sapiens	117-122
26139345-12	2015	Mutations in the proline-rich domain (PRD) of human AIPL1 cause severe retinal diseases, yet the role of PRD and the mechanisms of PRD mutations are unknown.	Proline	17-24	aryl hydrocarbon receptor interacting protein like 1	Homo sapiens	52-57
26420962-4	2015	A single nucleotide polymorphism (SNP) in the TP53 gene resulting in the presence of either arginine (Arg) or proline (Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties.	Proline	110-117	tumor protein p53	Homo sapiens	46-50
26420962-4	2015	A single nucleotide polymorphism (SNP) in the TP53 gene resulting in the presence of either arginine (Arg) or proline (Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties.	Proline	110-117	tumor protein p53	Homo sapiens	163-167
26420962-4	2015	A single nucleotide polymorphism (SNP) in the TP53 gene resulting in the presence of either arginine (Arg) or proline (Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties.	Proline	119-122	tumor protein p53	Homo sapiens	46-50
26420962-4	2015	A single nucleotide polymorphism (SNP) in the TP53 gene resulting in the presence of either arginine (Arg) or proline (Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties.	Proline	119-122	tumor protein p53	Homo sapiens	163-167
26400357-7	2015	Conversely, compared with WT, anti-sense ICE1 transgenic lines had lower proline levels and higher malonaldehyde levels under freezing conditions.	Proline	73-80	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	41-45
26082174-0	2015	Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway.	Proline	14-21	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	88-92
26082174-4	2015	Therefore, an RNAi screen of a kinase library was undertaken, identifying aldehyde dehydrogenase 18 family, member A1 (ALDH18A1) as a critically important gene in regulating melanoma cell growth through proline biosynthesis.	Proline	203-210	aldehyde dehydrogenase 18 family member A1	Homo sapiens	74-117
26082174-4	2015	Therefore, an RNAi screen of a kinase library was undertaken, identifying aldehyde dehydrogenase 18 family, member A1 (ALDH18A1) as a critically important gene in regulating melanoma cell growth through proline biosynthesis.	Proline	203-210	aldehyde dehydrogenase 18 family member A1	Homo sapiens	119-127
26082174-7	2015	Mechanistically, targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis, which could be reversed with proline supplementation.	Proline	183-190	aldehyde dehydrogenase 18 family member A1	Homo sapiens	27-35
26082174-7	2015	Mechanistically, targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis, which could be reversed with proline supplementation.	Proline	183-190	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	82-86
26082174-7	2015	Mechanistically, targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis, which could be reversed with proline supplementation.	Proline	183-190	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	88-122
26082174-8	2015	Thus, targeting ALDH18A1 in melanoma can be used to disrupt proline biosynthesis to limit cell metabolism thereby increasing the cellular doubling time mediated through the GCN2 pathway.	Proline	60-67	aldehyde dehydrogenase 18 family member A1	Homo sapiens	16-24
26082174-8	2015	Thus, targeting ALDH18A1 in melanoma can be used to disrupt proline biosynthesis to limit cell metabolism thereby increasing the cellular doubling time mediated through the GCN2 pathway.	Proline	60-67	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	173-177
26305679-3	2015	Here, we show that a stretch of proline residues located within the N-terminus of androgen receptor (AR) is a bona fide coregulator binding surface, the disruption of which reduces the androgen-dependent proliferation and migration of prostate cancer (PCa) cells.	Proline	32-39	androgen receptor	Homo sapiens	82-99
26305679-3	2015	Here, we show that a stretch of proline residues located within the N-terminus of androgen receptor (AR) is a bona fide coregulator binding surface, the disruption of which reduces the androgen-dependent proliferation and migration of prostate cancer (PCa) cells.	Proline	32-39	androgen receptor	Homo sapiens	101-103
26395440-0	2015	Tau phosphorylation regulates the interaction between BIN1"s SH3 domain and Tau"s proline-rich domain.	Proline	82-89	bridging integrator 1	Homo sapiens	54-58
26379774-7	2015	Furthermore, the enhancement of proline or myo-inositol synthesis by overexpressing key gene PRO1 or INO1 conferred yeast strain significantly increased FAP tolerance.	Proline	32-39	glutamate 5-kinase	Saccharomyces cerevisiae S288C	93-97
26383098-5	2015	BnPRP1 has 40.5% identity with a known proline-rich antimicrobial peptide SP-B from the pig.	Proline	39-46	surfactant protein B	Sus scrofa	74-78
26379774-7	2015	Furthermore, the enhancement of proline or myo-inositol synthesis by overexpressing key gene PRO1 or INO1 conferred yeast strain significantly increased FAP tolerance.	Proline	32-39	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	101-105
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Proline	271-274	tumor protein p53	Homo sapiens	40-43
26260980-5	2015	This binding mode resembles that of glutamate bound to the proline catabolic enzyme ALDH4A1.	Proline	59-66	aldehyde dehydrogenase 4 family member A1	Homo sapiens	84-91
26002808-8	2015	Human ORC1, ORC2, and SLC25A29 are likely to be involved in the biosynthesis and transport of arginine, which can be used as a precursor for the synthesis of NO, agmatine, polyamines, creatine, glutamine, glutamate, and proline, as well as in the degradation of basic amino acids.	Proline	220-227	origin recognition complex subunit 1	Homo sapiens	6-10
26002808-8	2015	Human ORC1, ORC2, and SLC25A29 are likely to be involved in the biosynthesis and transport of arginine, which can be used as a precursor for the synthesis of NO, agmatine, polyamines, creatine, glutamine, glutamate, and proline, as well as in the degradation of basic amino acids.	Proline	220-227	origin recognition complex subunit 2	Homo sapiens	12-16
26002808-8	2015	Human ORC1, ORC2, and SLC25A29 are likely to be involved in the biosynthesis and transport of arginine, which can be used as a precursor for the synthesis of NO, agmatine, polyamines, creatine, glutamine, glutamate, and proline, as well as in the degradation of basic amino acids.	Proline	220-227	solute carrier family 25 member 29	Homo sapiens	22-30
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Proline	262-269	tumor protein p53	Homo sapiens	40-43
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Proline	262-269	H3 histone pseudogene 16	Homo sapiens	48-51
26355749-3	2015	During evolution, at the transition of great apes to humanoids, the CYP4B1 protein acquired a serine instead of a proline at the canonical position 427 in the meander region.	Proline	114-121	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	68-74
26345619-7	2015	Further analysis indicated that the combined mutations of Ile 115 and Pro 214, positioned on the lateral surface of the Stp1 N-domain, fully accounted for the enhanced transport activity.	Proline	70-73	Stp1p	Saccharomyces cerevisiae S288C	120-124
26320891-2	2015	They are caused by biallelic mutations in PYCR1 or ALDH18A1, encoding pyrroline-5-carboxylate reductase 1 and pyrroline-5-carboxylate synthase (P5CS), respectively, which both operate in the mitochondrial proline cycle.	Proline	205-212	pyrroline-5-carboxylate reductase 1	Homo sapiens	42-47
26320891-2	2015	They are caused by biallelic mutations in PYCR1 or ALDH18A1, encoding pyrroline-5-carboxylate reductase 1 and pyrroline-5-carboxylate synthase (P5CS), respectively, which both operate in the mitochondrial proline cycle.	Proline	205-212	aldehyde dehydrogenase 18 family member A1	Homo sapiens	51-59
26320891-2	2015	They are caused by biallelic mutations in PYCR1 or ALDH18A1, encoding pyrroline-5-carboxylate reductase 1 and pyrroline-5-carboxylate synthase (P5CS), respectively, which both operate in the mitochondrial proline cycle.	Proline	205-212	pyrroline-5-carboxylate reductase 1	Homo sapiens	70-105
26320891-2	2015	They are caused by biallelic mutations in PYCR1 or ALDH18A1, encoding pyrroline-5-carboxylate reductase 1 and pyrroline-5-carboxylate synthase (P5CS), respectively, which both operate in the mitochondrial proline cycle.	Proline	205-212	aldehyde dehydrogenase 18 family member A1	Homo sapiens	110-142
26320891-2	2015	They are caused by biallelic mutations in PYCR1 or ALDH18A1, encoding pyrroline-5-carboxylate reductase 1 and pyrroline-5-carboxylate synthase (P5CS), respectively, which both operate in the mitochondrial proline cycle.	Proline	205-212	aldehyde dehydrogenase 18 family member A1	Homo sapiens	144-148
26320891-8	2015	Furthermore, we found that the mutant cells had a reduced P5CS enzymatic activity leading to a delayed proline accumulation.	Proline	103-110	aldehyde dehydrogenase 18 family member A1	Homo sapiens	58-62
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Proline	271-274	H3 histone pseudogene 16	Homo sapiens	48-51
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Proline	276-279	tumor protein p53	Homo sapiens	40-43
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Proline	276-279	H3 histone pseudogene 16	Homo sapiens	48-51
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Proline	276-279	tumor protein p53	Homo sapiens	40-43
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Proline	276-279	H3 histone pseudogene 16	Homo sapiens	48-51
26186480-5	2015	The fluorescence imaging and analysis by flow cytometry revealed that the ligand with 9 proline linkers binds to CXCR4 with remarkable specificity.	Proline	88-95	C-X-C motif chemokine receptor 4	Homo sapiens	113-118
26241057-0	2015	Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action.	Proline	22-29	WNK lysine deficient protein kinase 1	Mus musculus	50-54
26241057-5	2015	We identified 2 alternatively spliced exons embedded within a proline-rich region of WNK1 that contain PY motifs, which bind the E3 ubiquitin ligase NEDD4-2.	Proline	62-69	WNK lysine deficient protein kinase 1	Mus musculus	85-89
26241057-5	2015	We identified 2 alternatively spliced exons embedded within a proline-rich region of WNK1 that contain PY motifs, which bind the E3 ubiquitin ligase NEDD4-2.	Proline	62-69	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	149-156
26241057-8	2015	Aldosterone infusion increased proline-rich WNK1 isoform abundance in WT mice but did not alter WNK1 abundance in hypertensive Nedd4-2 KO mice, which exhibit high baseline WNK1 and SPAK/OSR1 activity toward NCC.	Proline	31-38	WNK lysine deficient protein kinase 1	Mus musculus	44-48
26241057-10	2015	Together, our findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 substrate, thereby linking aldosterone and other NEDD4-2-suppressing antinatriuretic hormones to NCC phosphorylation status.	Proline	41-48	WNK lysine deficient protein kinase 1	Mus musculus	95-99
26241057-10	2015	Together, our findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 substrate, thereby linking aldosterone and other NEDD4-2-suppressing antinatriuretic hormones to NCC phosphorylation status.	Proline	41-48	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	107-114
26241057-10	2015	Together, our findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 substrate, thereby linking aldosterone and other NEDD4-2-suppressing antinatriuretic hormones to NCC phosphorylation status.	Proline	41-48	neural precursor cell expressed, developmentally down-regulated 4	Mus musculus	107-112
26228428-7	2015	We could show that a lack of SLC6A15 reduced hippocampal tissue levels of proline and other neutral amino acids.	Proline	74-81	solute carrier family 6 member 15	Homo sapiens	29-36
26055684-3	2015	One gene of particular interest is the gene coding for proline dehydrogenase (PRODH), an enzyme responsible for the conversion of proline into glutamate.	Proline	55-62	proline dehydrogenase 1	Homo sapiens	78-83
26240315-6	2015	PDI5 and NAI2 are negative regulatory factors, as pdi5, nai2, and pdi5-2nai2-3 mutants had increased growth and proline accumulation at low water potential.	Proline	112-119	PDI-like 1-1	Arabidopsis thaliana	0-4
26068888-8	2015	A significant interaction effect of proline levels and COMT Val(158)Met genotype was found for SR (F 1,16 = 7.9; p = 0.01; partial eta (2) = 0.33), but not for PPI and FSIQ.	Proline	36-43	catechol-O-methyltransferase	Homo sapiens	55-59
26068888-9	2015	In subjects with hyperprolinemia, the COMT Val(158)Met genotype effect on SR was stronger than in subjects with normal proline levels.	Proline	22-29	catechol-O-methyltransferase	Homo sapiens	38-42
26317500-7	2015	Avr3b contains a putative Glycine-Proline (GP) motif; which is known to confer cyclophilin-binding in other protein substrates.	Proline	34-41	peptidyl-prolyl cis-trans isomerase 1	Glycine max	79-90
26236013-0	2015	Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis.	Proline	13-20	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
26236013-0	2015	Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis.	Proline	13-20	tumor protein p53	Homo sapiens	48-51
26236013-0	2015	Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis.	Proline	13-20	BCL2 associated X, apoptosis regulator	Homo sapiens	61-64
26236013-3	2015	We observed that cis-trans isomerization of proline 47 (Pro47) within p53, an inherently rare molecular event, was required for BAX activation.	Proline	44-51	tumor protein p53	Homo sapiens	70-73
26236013-3	2015	We observed that cis-trans isomerization of proline 47 (Pro47) within p53, an inherently rare molecular event, was required for BAX activation.	Proline	44-51	BCL2 associated X, apoptosis regulator	Homo sapiens	128-131
26240315-6	2015	PDI5 and NAI2 are negative regulatory factors, as pdi5, nai2, and pdi5-2nai2-3 mutants had increased growth and proline accumulation at low water potential.	Proline	112-119	DNA topoisomerase-like protein	Arabidopsis thaliana	9-13
26240315-6	2015	PDI5 and NAI2 are negative regulatory factors, as pdi5, nai2, and pdi5-2nai2-3 mutants had increased growth and proline accumulation at low water potential.	Proline	112-119	PDI-like 1-1	Arabidopsis thaliana	50-54
26240315-6	2015	PDI5 and NAI2 are negative regulatory factors, as pdi5, nai2, and pdi5-2nai2-3 mutants had increased growth and proline accumulation at low water potential.	Proline	112-119	DNA topoisomerase-like protein	Arabidopsis thaliana	56-60
26240315-6	2015	PDI5 and NAI2 are negative regulatory factors, as pdi5, nai2, and pdi5-2nai2-3 mutants had increased growth and proline accumulation at low water potential.	Proline	112-119	PDI-like 1-1	Arabidopsis thaliana	66-70
25935286-0	2015	Probing the role of Proline in the antimicrobial activity and lipopolysaccharide binding of indolicidin.	Proline	20-27	cathelicidin-4	Bos taurus	92-103
25935286-2	2015	An interesting feature of indolicidin is its unusually high content of Tryptophan and Proline residues.	Proline	86-93	cathelicidin-4	Bos taurus	26-37
25935286-4	2015	We herein investigate the structure and biological activities of indolicidin, where Proline at either one or more of the 3rd, 7th, 10th positions has been replaced by Alanine to better understand its structure and biological function.	Proline	84-91	cathelicidin-4	Bos taurus	65-76
25935286-5	2015	EXPERIMENTS: Structural aspects of Proline residues of indolicidin and its effect on antimicrobial activity were elucidated by replacing Proline residues with Alanine.	Proline	35-42	cathelicidin-4	Bos taurus	55-66
25935286-5	2015	EXPERIMENTS: Structural aspects of Proline residues of indolicidin and its effect on antimicrobial activity were elucidated by replacing Proline residues with Alanine.	Proline	137-144	cathelicidin-4	Bos taurus	55-66
25935286-8	2015	FINDINGS: Our study reveals that Proline residues are necessary for interaction of indolicidin with LPS and establishes the significance of the third and tenth Proline residues for its antimicrobial activity.	Proline	33-40	cathelicidin-4	Bos taurus	83-94
25935286-8	2015	FINDINGS: Our study reveals that Proline residues are necessary for interaction of indolicidin with LPS and establishes the significance of the third and tenth Proline residues for its antimicrobial activity.	Proline	160-167	cathelicidin-4	Bos taurus	83-94
25935286-9	2015	We believe that the presence of so many Proline residues provides the molecule a selective advantage of adopting different conformations varying from a globular, closed conformation to an open extended conformation, and even to a wedge-shaped conformation, which account for the diverse mechanisms of action of indolicidin.	Proline	40-47	cathelicidin-4	Bos taurus	311-322
26094604-0	2015	Epigenetic regulation of embryonic stem cell marker miR302C in human chondrosarcoma as determinant of antiproliferative activity of proline-rich polypeptide 1.	Proline	132-139	microRNA 302c	Homo sapiens	52-59
26274777-4	2015	We show in atomic detail that RBP C-terminal SH3 domains bind a proline-rich (PxxP) motif of Aplip1/JIP1 with submicromolar affinity.	Proline	64-71	RIM-binding protein	Drosophila melanogaster	30-33
26274777-4	2015	We show in atomic detail that RBP C-terminal SH3 domains bind a proline-rich (PxxP) motif of Aplip1/JIP1 with submicromolar affinity.	Proline	64-71	APP-like protein interacting protein 1	Drosophila melanogaster	93-99
26274777-4	2015	We show in atomic detail that RBP C-terminal SH3 domains bind a proline-rich (PxxP) motif of Aplip1/JIP1 with submicromolar affinity.	Proline	64-71	APP-like protein interacting protein 1	Drosophila melanogaster	100-104
26138675-9	2015	We further find that Proline 245 in TM4 of Orai1 is essential for stabilizing the closed state of the channel.	Proline	21-28	ORAI calcium release-activated calcium modulator 1	Homo sapiens	43-48
26018465-4	2015	We also showed that the presence of three proline residues, at positions 119, 159 and 178 of gag-p26, was significantly correlated with low viral load.	Proline	42-49	transmembrane p24 trafficking protein 3	Homo sapiens	97-100
25982396-4	2015	Structurally, the maBPI/LBP showed highly similar to those of BPI/LBPs from invertebrate and teleost, LBPs and BPIs from mammal, which contained an N-terminal BPI/LBP/CETP domain BPI1 with a LPS-binding domain, a C-terminal BPI/LBP/CETP domain BPI2, and proline-rich domain.	Proline	254-261	lipopolysaccharide binding protein	Homo sapiens	24-27
25982396-4	2015	Structurally, the maBPI/LBP showed highly similar to those of BPI/LBPs from invertebrate and teleost, LBPs and BPIs from mammal, which contained an N-terminal BPI/LBP/CETP domain BPI1 with a LPS-binding domain, a C-terminal BPI/LBP/CETP domain BPI2, and proline-rich domain.	Proline	254-261	bactericidal permeability increasing protein	Homo sapiens	20-23
25982396-4	2015	Structurally, the maBPI/LBP showed highly similar to those of BPI/LBPs from invertebrate and teleost, LBPs and BPIs from mammal, which contained an N-terminal BPI/LBP/CETP domain BPI1 with a LPS-binding domain, a C-terminal BPI/LBP/CETP domain BPI2, and proline-rich domain.	Proline	254-261	bactericidal permeability increasing protein	Homo sapiens	62-65
25982396-4	2015	Structurally, the maBPI/LBP showed highly similar to those of BPI/LBPs from invertebrate and teleost, LBPs and BPIs from mammal, which contained an N-terminal BPI/LBP/CETP domain BPI1 with a LPS-binding domain, a C-terminal BPI/LBP/CETP domain BPI2, and proline-rich domain.	Proline	254-261	lipopolysaccharide binding protein	Homo sapiens	66-69
25982396-4	2015	Structurally, the maBPI/LBP showed highly similar to those of BPI/LBPs from invertebrate and teleost, LBPs and BPIs from mammal, which contained an N-terminal BPI/LBP/CETP domain BPI1 with a LPS-binding domain, a C-terminal BPI/LBP/CETP domain BPI2, and proline-rich domain.	Proline	254-261	bactericidal permeability increasing protein	Homo sapiens	62-65
25982396-4	2015	Structurally, the maBPI/LBP showed highly similar to those of BPI/LBPs from invertebrate and teleost, LBPs and BPIs from mammal, which contained an N-terminal BPI/LBP/CETP domain BPI1 with a LPS-binding domain, a C-terminal BPI/LBP/CETP domain BPI2, and proline-rich domain.	Proline	254-261	lipopolysaccharide binding protein	Homo sapiens	66-69
26574473-3	2015	The binding of HIFalpha for VCB is increased by ~1000-fold upon addition of a single hydroxyl group to either of two conserved proline-residues.	Proline	127-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-23
26284089-4	2015	The terminal step of both pathways, the conversion of delta(1)-pyrroline-5-carboxylate (P5C) to L-proline, is catalyzed by P5C reductase (P5CR) using NADH or NADPH as a cofactor.	Proline	96-105	pyrroline-5-carboxylate reductase 1	Homo sapiens	54-86
26284089-4	2015	The terminal step of both pathways, the conversion of delta(1)-pyrroline-5-carboxylate (P5C) to L-proline, is catalyzed by P5C reductase (P5CR) using NADH or NADPH as a cofactor.	Proline	96-105	pyrroline-5-carboxylate reductase 1	Homo sapiens	88-91
26284089-4	2015	The terminal step of both pathways, the conversion of delta(1)-pyrroline-5-carboxylate (P5C) to L-proline, is catalyzed by P5C reductase (P5CR) using NADH or NADPH as a cofactor.	Proline	96-105	pyrroline-5-carboxylate reductase 1	Homo sapiens	123-136
26284089-4	2015	The terminal step of both pathways, the conversion of delta(1)-pyrroline-5-carboxylate (P5C) to L-proline, is catalyzed by P5C reductase (P5CR) using NADH or NADPH as a cofactor.	Proline	96-105	pyrroline-5-carboxylate reductase 1	Homo sapiens	138-142
26284089-4	2015	The terminal step of both pathways, the conversion of delta(1)-pyrroline-5-carboxylate (P5C) to L-proline, is catalyzed by P5C reductase (P5CR) using NADH or NADPH as a cofactor.	Proline	96-105	2,4-dienoyl-CoA reductase 1	Homo sapiens	158-163
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Proline	120-127	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-8
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Proline	120-127	aldehyde dehydrogenase 18 family member A1	Homo sapiens	17-57
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Proline	120-127	aldehyde dehydrogenase 18 family member A1	Homo sapiens	59-63
26026163-6	2015	Low levels of plasma ornithine, citrulline, arginine and proline in four individuals from two families suggested P5CS deficiency.	Proline	57-64	aldehyde dehydrogenase 18 family member A1	Homo sapiens	113-117
25982064-0	2015	Molecular phenotype of tissue-nonspecific alkaline phosphatase with a proline (108) to leucine substitution associated with dominant odontohypophosphatasia.	Proline	70-77	alkaline phosphatase, placental	Homo sapiens	42-62
25872741-0	2015	Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction.	Proline	89-96	epidermal growth factor receptor	Homo sapiens	38-70
26284090-3	2015	In the catabolic process, Pro is converted back to Glu using a different pathway that involves Pro dehydrogenase (ProDH), P5C dehydrogenase (P5CDH), and P5C as intermediate.	Proline	26-29	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	95-112
25827016-8	2015	AtbHLH112 mediates stress tolerance by increasing the expression of P5CS genes and reducing the expression of P5CDH and ProDH genes to increase proline levels.	Proline	144-151	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	110-115
26222500-3	2015	p110alpha-free p85alpha homodimerizes via two intermolecular interactions (SH3:proline-rich region and BH:BH) to selectively bind unphosphorylated activated PTEN.	Proline	79-86	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	0-9
26222500-3	2015	p110alpha-free p85alpha homodimerizes via two intermolecular interactions (SH3:proline-rich region and BH:BH) to selectively bind unphosphorylated activated PTEN.	Proline	79-86	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	15-23
26222500-3	2015	p110alpha-free p85alpha homodimerizes via two intermolecular interactions (SH3:proline-rich region and BH:BH) to selectively bind unphosphorylated activated PTEN.	Proline	79-86	phosphatase and tensin homolog	Homo sapiens	157-161
26622617-7	2015	The number of cells stained with the apoptotic marker YO-PRO-1, the sub-G1 cell population and the level of apoptotic DNA fragmentation increased in the SCC-VII cells following treatment with recombinant tumstatin.	Proline	57-60	collagen, type IV, alpha 3	Mus musculus	204-213
26284090-3	2015	In the catabolic process, Pro is converted back to Glu using a different pathway that involves Pro dehydrogenase (ProDH), P5C dehydrogenase (P5CDH), and P5C as intermediate.	Proline	26-29	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	141-146
26284090-3	2015	In the catabolic process, Pro is converted back to Glu using a different pathway that involves Pro dehydrogenase (ProDH), P5C dehydrogenase (P5CDH), and P5C as intermediate.	Proline	26-29	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	114-119
26284090-3	2015	In the catabolic process, Pro is converted back to Glu using a different pathway that involves Pro dehydrogenase (ProDH), P5C dehydrogenase (P5CDH), and P5C as intermediate.	Proline	26-29	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	122-139
26207810-10	2015	However, the FKBP52 proline-rich loop that overhangs the PPIase pocket is critical for synergy.	Proline	20-27	FKBP prolyl isomerase 4	Homo sapiens	13-19
26207810-10	2015	However, the FKBP52 proline-rich loop that overhangs the PPIase pocket is critical for synergy.	Proline	20-27	FKBP prolyl isomerase 4	Homo sapiens	57-63
26110966-1	2015	The solubility-enhancing power of covalent attachment to solvent-swollen cross-linked resin supports was illustrated by syntheses of the highly aggregating elastin-derived 10-residue peptide sequence Pro-Gly-Val-Gly-Val-Pro-Gly-Val-Gly-Val using standard protocols for both Boc and Fmoc chemistry SPPS.	Proline	200-204	elastin	Homo sapiens	156-163
26110207-10	2015	Introducing proline in the catalytic domain stabilized SABP2 to the first unfolding in urea for three of five cases: L46P (+0.2 M urea), S70P (+0.1), and E215P (+0.9).	Proline	12-19	salicylic acid-binding protein 2	Nicotiana tabacum	55-60
26110207-12	2015	Proline substitutions in both domains stabilized SABP2 to heat inactivation: L46P (DeltaT1/2 15min = +6.4  C), S70P (+5.4), S115P (+1.8), S141P (+4.9), and E215P (+4.2).	Proline	0-7	salicylic acid-binding protein 2	Nicotiana tabacum	49-54
26110207-0	2015	Stabilization of an alpha/beta-Hydrolase by Introducing Proline Residues: Salicylic Acid Binding Protein 2 from Tobacco.	Proline	56-63	salicylic acid-binding protein 2	Nicotiana tabacum	74-106
26110207-7	2015	Replacing selected amino acid residues with proline stabilized SABP2.	Proline	44-51	salicylic acid-binding protein 2	Nicotiana tabacum	63-68
26110207-9	2015	Seven locations for proline substitution were chosen either by amino acid sequence alignment with a more stable homologue or by targeting flexible regions in SABP2.	Proline	20-27	salicylic acid-binding protein 2	Nicotiana tabacum	158-163
25998383-3	2015	The rsp5(W257F/P260A), rsp5(W359F/P362A), and rsp5(W415F/P418A) mutations increased sensitivity to the proline analog azetidine-2-carboxylate (AZC), defective endocytosis of Gap1, and impaired interactions with Bul1.	Proline	103-110	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	4-8
25998383-3	2015	The rsp5(W257F/P260A), rsp5(W359F/P362A), and rsp5(W415F/P418A) mutations increased sensitivity to the proline analog azetidine-2-carboxylate (AZC), defective endocytosis of Gap1, and impaired interactions with Bul1.	Proline	103-110	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	23-27
25998383-3	2015	The rsp5(W257F/P260A), rsp5(W359F/P362A), and rsp5(W415F/P418A) mutations increased sensitivity to the proline analog azetidine-2-carboxylate (AZC), defective endocytosis of Gap1, and impaired interactions with Bul1.	Proline	103-110	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	23-27
25998383-3	2015	The rsp5(W257F/P260A), rsp5(W359F/P362A), and rsp5(W415F/P418A) mutations increased sensitivity to the proline analog azetidine-2-carboxylate (AZC), defective endocytosis of Gap1, and impaired interactions with Bul1.	Proline	103-110	amino acid permease GAP1	Saccharomyces cerevisiae S288C	174-178
25998383-3	2015	The rsp5(W257F/P260A), rsp5(W359F/P362A), and rsp5(W415F/P418A) mutations increased sensitivity to the proline analog azetidine-2-carboxylate (AZC), defective endocytosis of Gap1, and impaired interactions with Bul1.	Proline	103-110	ubiquitin-ubiquitin ligase BUL1	Saccharomyces cerevisiae S288C	211-215
26110966-1	2015	The solubility-enhancing power of covalent attachment to solvent-swollen cross-linked resin supports was illustrated by syntheses of the highly aggregating elastin-derived 10-residue peptide sequence Pro-Gly-Val-Gly-Val-Pro-Gly-Val-Gly-Val using standard protocols for both Boc and Fmoc chemistry SPPS.	Proline	200-204	BOC cell adhesion associated, oncogene regulated	Homo sapiens	274-277
26018079-9	2015	Immunoprecipitation analysis showed that PLA/AT-3 binds to Pex19p through its N-terminal proline-rich and C-terminal hydrophobic domains.	Proline	89-96	ataxin 3	Homo sapiens	45-49
26163016-5	2015	In addition, the SH3 domains of Nck interacted with the proline rich region (PRR) of TSAd.	Proline	56-63	NCK adaptor protein 1	Homo sapiens	32-35
26163016-5	2015	In addition, the SH3 domains of Nck interacted with the proline rich region (PRR) of TSAd.	Proline	56-63	SH2 domain containing 2A	Homo sapiens	85-89
25870942-4	2015	In this study, we report a novel PBGD missense mutation, A G-to-C, at the position 988 resulting in Alanine to Proline (Ala330Pro), in a Chinese family.	Proline	111-118	hydroxymethylbilane synthase	Homo sapiens	33-37
26018079-9	2015	Immunoprecipitation analysis showed that PLA/AT-3 binds to Pex19p through its N-terminal proline-rich and C-terminal hydrophobic domains.	Proline	89-96	peroxisomal biogenesis factor 19	Homo sapiens	59-65
25999310-1	2015	WW domains harbor substrates containing proline-rich motifs, but the substrate specificity and binding mechanism remain elusive for those WW domains less amenable for structural studies, such as human WWP2 (hWWP2).	Proline	40-47	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	207-212
26135918-2	2015	A proline to leucine substitution at PrP residue 102 (P102L) is classically associated with Gerstmann-Straussler-Scheinker (GSS) disease but shows marked clinical and neuropathological variability within kindreds that may be caused by variable propagation of distinct prion strains generated from either PrP 102L or wild type PrP.	Proline	2-9	prion protein	Mus musculus	37-40
26135918-2	2015	A proline to leucine substitution at PrP residue 102 (P102L) is classically associated with Gerstmann-Straussler-Scheinker (GSS) disease but shows marked clinical and neuropathological variability within kindreds that may be caused by variable propagation of distinct prion strains generated from either PrP 102L or wild type PrP.	Proline	2-9	prion protein	Mus musculus	304-307
25797047-4	2015	The interaction is mediated by the SH3 domains of ITSNs and the middle part of the WIP proline-rich motifs.	Proline	87-94	WAS/WASL interacting protein family member 1	Homo sapiens	83-86
25979826-8	2015	eIF5A has been shown to regulate a number of gene products specifically, termed the eIF5A regulon, and its role in translating proline-rich sequences has recently been identified.	Proline	127-134	eukaryotic translation initiation factor 5A	Homo sapiens	0-5
26211588-0	2015	Increased expression of proline-, glutamic acid- and leucine-rich protein PELP1 in non-small cell lung cancer.	Proline	24-31	proline, glutamate and leucine rich protein 1	Homo sapiens	74-79
26051250-0	2015	A novel autoregulatory loop between the Gcn2-Atf4 pathway and l-Proline metabolism controls stem cell identity.	Proline	62-71	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	40-44
25857264-0	2015	A novel autoregulatory loop between the Gcn2-Atf4 pathway and (L)-Proline [corrected] metabolism controls stem cell identity.	Proline	62-73	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	40-44
25857264-0	2015	A novel autoregulatory loop between the Gcn2-Atf4 pathway and (L)-Proline [corrected] metabolism controls stem cell identity.	Proline	62-73	activating transcription factor 4	Homo sapiens	45-49
25857264-2	2015	Here, we demonstrate that embryonic stem cell (ESC) behaviour relies on a feedback loop that involves the non-essential amino acid L-Proline (L-Pro) in the modulation of the Gcn2-Eif2alpha-Atf4 amino acid starvation response (AAR) pathway that in turn regulates L-Pro biosynthesis.	Proline	131-140	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	174-178
25857264-2	2015	Here, we demonstrate that embryonic stem cell (ESC) behaviour relies on a feedback loop that involves the non-essential amino acid L-Proline (L-Pro) in the modulation of the Gcn2-Eif2alpha-Atf4 amino acid starvation response (AAR) pathway that in turn regulates L-Pro biosynthesis.	Proline	131-140	eukaryotic translation initiation factor 2A	Homo sapiens	179-188
25857264-2	2015	Here, we demonstrate that embryonic stem cell (ESC) behaviour relies on a feedback loop that involves the non-essential amino acid L-Proline (L-Pro) in the modulation of the Gcn2-Eif2alpha-Atf4 amino acid starvation response (AAR) pathway that in turn regulates L-Pro biosynthesis.	Proline	131-140	activating transcription factor 4	Homo sapiens	189-193
25857264-2	2015	Here, we demonstrate that embryonic stem cell (ESC) behaviour relies on a feedback loop that involves the non-essential amino acid L-Proline (L-Pro) in the modulation of the Gcn2-Eif2alpha-Atf4 amino acid starvation response (AAR) pathway that in turn regulates L-Pro biosynthesis.	Proline	131-136	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	174-178
25857264-2	2015	Here, we demonstrate that embryonic stem cell (ESC) behaviour relies on a feedback loop that involves the non-essential amino acid L-Proline (L-Pro) in the modulation of the Gcn2-Eif2alpha-Atf4 amino acid starvation response (AAR) pathway that in turn regulates L-Pro biosynthesis.	Proline	131-136	eukaryotic translation initiation factor 2A	Homo sapiens	179-188
25857264-2	2015	Here, we demonstrate that embryonic stem cell (ESC) behaviour relies on a feedback loop that involves the non-essential amino acid L-Proline (L-Pro) in the modulation of the Gcn2-Eif2alpha-Atf4 amino acid starvation response (AAR) pathway that in turn regulates L-Pro biosynthesis.	Proline	131-136	activating transcription factor 4	Homo sapiens	189-193
25857264-2	2015	Here, we demonstrate that embryonic stem cell (ESC) behaviour relies on a feedback loop that involves the non-essential amino acid L-Proline (L-Pro) in the modulation of the Gcn2-Eif2alpha-Atf4 amino acid starvation response (AAR) pathway that in turn regulates L-Pro biosynthesis.	Proline	142-147	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	174-178
26051250-0	2015	A novel autoregulatory loop between the Gcn2-Atf4 pathway and l-Proline metabolism controls stem cell identity.	Proline	62-71	activating transcription factor 4	Homo sapiens	45-49
25736604-9	2015	The results of affinity chromatography, fluorescent ELISA-like test, CD and NMR studies point to an importance of proline residues on structure of SAA(86-104).	Proline	114-121	serum amyloid A1 cluster	Homo sapiens	147-150
25857264-2	2015	Here, we demonstrate that embryonic stem cell (ESC) behaviour relies on a feedback loop that involves the non-essential amino acid L-Proline (L-Pro) in the modulation of the Gcn2-Eif2alpha-Atf4 amino acid starvation response (AAR) pathway that in turn regulates L-Pro biosynthesis.	Proline	142-147	eukaryotic translation initiation factor 2A	Homo sapiens	179-188
25857264-2	2015	Here, we demonstrate that embryonic stem cell (ESC) behaviour relies on a feedback loop that involves the non-essential amino acid L-Proline (L-Pro) in the modulation of the Gcn2-Eif2alpha-Atf4 amino acid starvation response (AAR) pathway that in turn regulates L-Pro biosynthesis.	Proline	142-147	activating transcription factor 4	Homo sapiens	189-193
25857264-5	2015	Either pharmacological inhibition of the prolyl-tRNA synthetase by halofuginone or forced expression of Atf4 antagonises the effects of exogenous L-Pro.	Proline	146-151	activating transcription factor 4	Homo sapiens	104-108
25232917-8	2015	Patients with homozygous Arg/arg at codon 72 of P53 had a better median OS months than Arg/Pro and Pro/Pro (13.4 vs. 8.4 vs. 1.5 months, respectively; P = 0.045).	Proline	91-94	tumor protein p53	Homo sapiens	48-51
25232917-8	2015	Patients with homozygous Arg/arg at codon 72 of P53 had a better median OS months than Arg/Pro and Pro/Pro (13.4 vs. 8.4 vs. 1.5 months, respectively; P = 0.045).	Proline	99-102	tumor protein p53	Homo sapiens	48-51
25232917-8	2015	Patients with homozygous Arg/arg at codon 72 of P53 had a better median OS months than Arg/Pro and Pro/Pro (13.4 vs. 8.4 vs. 1.5 months, respectively; P = 0.045).	Proline	99-102	tumor protein p53	Homo sapiens	48-51
26075818-6	2015	We have provided evidence that thyroid hormone receptor-alpha (TR-alpha), a transcriptional regulator of PLN, interacts with PHD2 and PHD3 and is hydroxylated at 2 proline residues.	Proline	164-171	thyroid hormone receptor alpha	Mus musculus	31-61
26075818-6	2015	We have provided evidence that thyroid hormone receptor-alpha (TR-alpha), a transcriptional regulator of PLN, interacts with PHD2 and PHD3 and is hydroxylated at 2 proline residues.	Proline	164-171	thioredoxin reductase 1	Mus musculus	63-71
26075818-6	2015	We have provided evidence that thyroid hormone receptor-alpha (TR-alpha), a transcriptional regulator of PLN, interacts with PHD2 and PHD3 and is hydroxylated at 2 proline residues.	Proline	164-171	phospholamban	Mus musculus	105-108
26070063-6	2015	The accumulation of proline during priming and post-priming germination was associated with strong up-regulation of the P5CSA gene, down-regulation of the PDH gene and accumulation of hydrogen peroxide.	Proline	20-27	proline dehydrogenase 1, mitochondrial	Brassica napus	155-158
25263537-5	2015	Conversely ahk2-2 was hypersensitive to salt stress in terms of root growth and fresh weight and accumulated higher than wild-type levels of proline specifically under salt stress.	Proline	141-148	histidine kinase 2	Arabidopsis thaliana	11-15
25777305-3	2015	The investigation identified five somatic non-synonymous coding mutations in four candidate genes, with two located in the proline, glutamic acid, serine, threonine-rich region of myeloid cell leukemia sequence 1 (Mcl)-1, (D155G and L174S).	Proline	123-130	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	193-220
26557159-10	2015	In FGFR3 gene 10/TM location of 1172 the nucleotide changes C&gt;A, Ala 391 Glu 19/56 and Exon-19, 5q35.2 at conserved linker region the changes occurred pro 246 Arg in 25/56 families.	Proline	154-157	fibroblast growth factor receptor 3	Homo sapiens	3-8
25263537-7	2015	Reduced P5CS1 (Delta(1) -pyrroline-5-carboxylate synthetase1) gene expression may have contributed to this reduced proline accumulation.	Proline	115-122	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	8-13
25931121-4	2015	Here we describe that co-expression of this I-II loop or its proximal region (Delta1-Cav3.2; Ser(423)-Pro(542)) together with recombinant full-length Cav3.2 channel inhibited T-type current without affecting channel expression and membrane incorporation.	Proline	102-105	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	150-156
26123760-10	2015	However, a significant association between p53 Arg72Pro polymorphism and the risk of oral cancer with HPV infection was detected in the Arg/Arg vs. Arg/Pro + Pro/Pro model.	Proline	52-55	tumor protein p53	Homo sapiens	43-46
26123760-10	2015	However, a significant association between p53 Arg72Pro polymorphism and the risk of oral cancer with HPV infection was detected in the Arg/Arg vs. Arg/Pro + Pro/Pro model.	Proline	152-155	tumor protein p53	Homo sapiens	43-46
26123760-10	2015	However, a significant association between p53 Arg72Pro polymorphism and the risk of oral cancer with HPV infection was detected in the Arg/Arg vs. Arg/Pro + Pro/Pro model.	Proline	152-155	tumor protein p53	Homo sapiens	43-46
26121399-5	2015	nNOS-overexpressing plants exhibited stronger water-holding capability, higher proline accumulation, less lipid peroxidation and reduced electrolyte leakage under drought and salt conditions than wild rice.	Proline	79-86	nitric oxide synthase 1	Rattus norvegicus	0-4
26121399-9	2015	Taken together, our results suggest that nNOS overexpression suppresses the stress-enhanced electrolyte leakage, lipid peroxidation and H2O2 accumulation, and promotes proline accumulation and the expression of stress-responsive genes under stress conditions, thereby promoting increased tolerance to drought and salt stresses.	Proline	168-175	nitric oxide synthase 1	Rattus norvegicus	41-45
25809153-8	2015	Transcriptomic analysis indicates that the CtHSR1 transgenic plants overexpressed a hundred of genes, including many relevant to stress defense such as LOX4 (involved in jasmonic acid synthesis) and P5CS1 (involved in proline biosynthesis).	Proline	218-225	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	199-204
26121966-2	2015	Here we investigate the reasons underlying the conservation of the cis proline that is diagnostic for the fold of thioredoxin-like thiol-disulfide oxidoreductases.	Proline	71-78	thioredoxin	Homo sapiens	114-125
26121966-3	2015	We show that replacement of the conserved cis proline in thioredoxin by alanine can accelerate spontaneous folding to the native, thermodynamically most stable state by more than four orders of magnitude.	Proline	46-53	thioredoxin	Homo sapiens	57-68
26107960-2	2015	Here, we demonstrate that an N-terminal proline-rich interaction region is crucial for Foxp3"s function.	Proline	40-47	forkhead box P3	Homo sapiens	87-92
26161086-3	2015	Mutants of Delta (1)-Pyrroline-5-Carboxylate Synthetase1 (P5CS1) and Proline Dehydrogenase1 (PDH1), key enzymes in proline synthesis and catabolism respectively, both have similar reductions in growth during controlled soil drying.	Proline	115-122	proline dehydrogenase 1	Homo sapiens	69-91
26161086-3	2015	Mutants of Delta (1)-Pyrroline-5-Carboxylate Synthetase1 (P5CS1) and Proline Dehydrogenase1 (PDH1), key enzymes in proline synthesis and catabolism respectively, both have similar reductions in growth during controlled soil drying.	Proline	115-122	proline dehydrogenase 1	Homo sapiens	93-97
26161086-6	2015	An example of this is immunoblot detection of P5CS1 and PDH1 showing that the Highly ABA-induced (HAI) protein phosphatase 2Cs (PP2Cs) have different effects on P5CS1 and PDH1 protein levels despite having similar increases in proline accumulation.	Proline	227-234	proline dehydrogenase 1	Homo sapiens	56-60
26161086-6	2015	An example of this is immunoblot detection of P5CS1 and PDH1 showing that the Highly ABA-induced (HAI) protein phosphatase 2Cs (PP2Cs) have different effects on P5CS1 and PDH1 protein levels despite having similar increases in proline accumulation.	Proline	227-234	proline dehydrogenase 1	Homo sapiens	171-175
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Proline	228-231	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	30-35
26084567-5	2015	Phosphorylation of up to six serine/threonine-proline sites contributes additively to regulation of NeuroD4 proneural activity without altering neuronal subtype specification, and number rather than location of available phospho-sites is the key for limiting NeuroD4 activity.	Proline	46-53	neuronal differentiation 4 L homeolog	Xenopus laevis	100-107
26084567-5	2015	Phosphorylation of up to six serine/threonine-proline sites contributes additively to regulation of NeuroD4 proneural activity without altering neuronal subtype specification, and number rather than location of available phospho-sites is the key for limiting NeuroD4 activity.	Proline	46-53	neuronal differentiation 4 L homeolog	Xenopus laevis	259-266
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Proline	228-231	calcium/calmodulin dependent protein kinase ID	Homo sapiens	105-115
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Proline	228-231	calcium/calmodulin dependent protein kinase I	Homo sapiens	120-130
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Proline	228-231	calcium/calmodulin dependent protein kinase ID	Homo sapiens	216-226
25882849-4	2015	WTX interacted with the coiled coil domain of TRIM28 required for its binding to Kruppel-associated box domains of transcription factors and for its chromatin recruitment through its own coiled coil and proline-rich domains.	Proline	203-210	APC membrane recruitment 1	Mus musculus	0-3
25882849-4	2015	WTX interacted with the coiled coil domain of TRIM28 required for its binding to Kruppel-associated box domains of transcription factors and for its chromatin recruitment through its own coiled coil and proline-rich domains.	Proline	203-210	tripartite motif-containing 28	Mus musculus	46-52
25911318-1	2015	Phospholipase Cbeta1b (PLCbeta1b) is an atypical splice variant of PLCbeta1 that has a C-terminal proline-rich sequence instead of the PDZ-interacting motif common to other PLCbeta subtypes.	Proline	98-105	phospholipase C beta 1	Homo sapiens	23-31
25911318-4	2015	Mutating proline residues in the extreme C-terminal region of PLCbeta1b prevented the interaction between PLCbeta1b and Shank3 resulting in reduced sarcolemmal localization and downstream signalling responses.	Proline	9-16	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	120-126
25935222-5	2015	For the recognition of each amino acid (here, serine, proline, glycine, asparagine, leucine, and histidine), the corresponding aminoacyl-tRNA synthetase (aaRS) was employed, and multiple enzymatic reactions were combined with a luminol chemiluminescence reaction.	Proline	54-61	alanyl-tRNA synthetase 1	Homo sapiens	154-158
25911318-5	2015	We conclude that PLCbeta1b activation and downstream signalling require the association of a previously unidentified C-terminal proline-rich motif with the SH3 domain of Shank3.	Proline	128-135	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	170-176
25882913-7	2015	We showed that the P56 residue within the SH3 motif is critical for virus lifecycle as mutation resulted in a loss of virus infectivity, however the P50 and P53 mutations did not abolish virus infectivity suggesting that these highly conserved proline residues within the SH3 motif may provide a selective growth advantage through interactions with the host rather than a vital functional element.	Proline	244-251	cyclin dependent kinase like 2	Homo sapiens	19-22
25088203-9	2015	BMI1 consists of a ring finger (RF), helix-turn-helix-turn-helix-turn (HT), proline/serine (PS) domain and two nuclear localization signals (NLS).	Proline	76-83	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	0-4
26037503-6	2015	We show that MAP6 acts downstream of receptor activation through a mechanism that requires a proline-rich domain distinct from its microtubule-stabilizing domains.	Proline	93-100	microtubule-associated protein 6	Mus musculus	13-17
25442010-3	2015	Through DNA sequencing and the PCR-single-strand conformation polymorphism method, a novel 9-bp nucleotide insertion (+) or deletion (-) was detected on exon 2 of SFTPA1, which causes a change in three amino acids, namely, alanine (Ala), glycine (Gly) and proline (Pro).	Proline	256-263	pulmonary surfactant-associated protein A	Sus scrofa	163-169
25442010-3	2015	Through DNA sequencing and the PCR-single-strand conformation polymorphism method, a novel 9-bp nucleotide insertion (+) or deletion (-) was detected on exon 2 of SFTPA1, which causes a change in three amino acids, namely, alanine (Ala), glycine (Gly) and proline (Pro).	Proline	265-268	pulmonary surfactant-associated protein A	Sus scrofa	163-169
25564338-6	2015	Among MMP clones, MMP-2 catalytic domain and MMP-9 clone containing pro, catalytic and hemopexin domain were most active.	Proline	68-71	matrix metallopeptidase 2	Homo sapiens	6-9
25840370-0	2015	The cis conformation of proline leads to weaker binding of a p53 peptide to MDM2 compared to trans.	Proline	24-31	tumor protein p53	Homo sapiens	61-64
25840370-0	2015	The cis conformation of proline leads to weaker binding of a p53 peptide to MDM2 compared to trans.	Proline	24-31	MDM2 proto-oncogene	Homo sapiens	76-80
25840370-3	2015	In this study, computer simulations were used to calculate the absolute binding affinity for a p53 peptide (residues 17-29) to MDM2 for both cis and trans isomers of the p53 proline in position 27.	Proline	174-181	tumor protein p53	Homo sapiens	95-98
25840370-3	2015	In this study, computer simulations were used to calculate the absolute binding affinity for a p53 peptide (residues 17-29) to MDM2 for both cis and trans isomers of the p53 proline in position 27.	Proline	174-181	MDM2 proto-oncogene	Homo sapiens	127-131
25840370-3	2015	In this study, computer simulations were used to calculate the absolute binding affinity for a p53 peptide (residues 17-29) to MDM2 for both cis and trans isomers of the p53 proline in position 27.	Proline	174-181	tumor protein p53	Homo sapiens	170-173
25905439-8	2015	With regard to prolyl residues around the phosphorylation site of Amph1, Pro-291 at the P -2 position, but not Pro-294 at the P +1 position, is indispensable for phosphorylation by CDKL5.	Proline	73-76	amphiphysin	Homo sapiens	66-71
25863351-1	2015	Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyses proline-containing peptides at the carboxy terminus of proline residues.	Proline	70-77	prolyl endopeptidase	Homo sapiens	0-21
25863351-1	2015	Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyses proline-containing peptides at the carboxy terminus of proline residues.	Proline	125-132	prolyl endopeptidase	Homo sapiens	0-21
26521443-0	2015	[Design, synthesis and evaluation of new L-proline derivatives as acetylcholinesterase inhibitors].	Proline	41-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-86
26521443-5	2015	So the acetylcholinesterase inhibitory activities of new L-proline derivatives were worth to be further studied.	Proline	57-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	7-27
25564338-6	2015	Among MMP clones, MMP-2 catalytic domain and MMP-9 clone containing pro, catalytic and hemopexin domain were most active.	Proline	68-71	matrix metallopeptidase 9	Homo sapiens	45-50
25957952-6	2015	The HPR motif, which is highly conserved among TIL proteins, extends over as short stretch of eight amino acids and contains four invariant proline residues.	Proline	140-147	temperature-induced lipocalin	Arabidopsis thaliana	47-50
26024867-3	2015	Rapamycin inhibition of TorC1 elicits nuclear localization of Gln3, a GATA-family transcription activator responsible for the expression of genes encoding proteins required to transport and degrade poor nitrogen sources, e.g., proline.	Proline	227-234	CREB regulated transcription coactivator 1	Homo sapiens	24-29
26024867-3	2015	Rapamycin inhibition of TorC1 elicits nuclear localization of Gln3, a GATA-family transcription activator responsible for the expression of genes encoding proteins required to transport and degrade poor nitrogen sources, e.g., proline.	Proline	227-234	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	70-74
25905439-8	2015	With regard to prolyl residues around the phosphorylation site of Amph1, Pro-291 at the P -2 position, but not Pro-294 at the P +1 position, is indispensable for phosphorylation by CDKL5.	Proline	73-76	cyclin dependent kinase like 5	Homo sapiens	181-186
25905439-9	2015	Phosphorylation experiments using various deletion mutants of Amph1 revealed that the proline-rich domain (PRD) (amino acids 247-315) alone was not phosphorylated by CDKL5.	Proline	86-93	amphiphysin	Homo sapiens	62-67
25865492-2	2015	Here, we report mutations in PYCR2, which encodes an enzyme in the proline biosynthesis pathway, as the cause of a unique syndrome characterized by postnatal microcephaly, hypomyelination, and reduced cerebral white-matter volume.	Proline	67-74	pyrroline-5-carboxylate reductase 2	Homo sapiens	29-34
25833397-0	2015	CD28 Promotes Plasma Cell Survival, Sustained Antibody Responses, and BLIMP-1 Upregulation through Its Distal PYAP Proline Motif.	Proline	115-122	CD28 antigen	Mus musculus	0-4
25855814-7	2015	The conserved proline-rich linker connecting the N- and C-terminal domains of Rrs1 wrap around the side of Rpf2 and anchor the C-terminal domain of Rrs1 to a specific site on Rpf2.	Proline	14-21	Rrs1p	Saccharomyces cerevisiae S288C	78-82
25855814-7	2015	The conserved proline-rich linker connecting the N- and C-terminal domains of Rrs1 wrap around the side of Rpf2 and anchor the C-terminal domain of Rrs1 to a specific site on Rpf2.	Proline	14-21	rRNA-binding ribosome biosynthesis protein RPF2	Saccharomyces cerevisiae S288C	107-111
25855814-7	2015	The conserved proline-rich linker connecting the N- and C-terminal domains of Rrs1 wrap around the side of Rpf2 and anchor the C-terminal domain of Rrs1 to a specific site on Rpf2.	Proline	14-21	Rrs1p	Saccharomyces cerevisiae S288C	148-152
25855814-7	2015	The conserved proline-rich linker connecting the N- and C-terminal domains of Rrs1 wrap around the side of Rpf2 and anchor the C-terminal domain of Rrs1 to a specific site on Rpf2.	Proline	14-21	rRNA-binding ribosome biosynthesis protein RPF2	Saccharomyces cerevisiae S288C	175-179
26124874-6	2015	This novel multifunctional hPG-peptide conjugate displayed a K D of 17.6 microM which demonstrates that the new carrier provides a venue for the future inhibition of proline-rich sequence recognition by FBP21 during assembly of the spliceosome.	Proline	166-173	WW domain binding protein 4	Homo sapiens	203-208
25786414-10	2015	We show that Ascl1"s ability to induce differentiation of AVNA cells is inhibited by its multi-site phosphorylation at serine-proline motifs, whereas overexpression of cyclin-dependent kinases (CDKs) and MYCN inhibit wild-type Ascl1-driven AVNA differentiation, but not differentiation driven by a phospho-mutant form of Ascl1.	Proline	126-133	achaete-scute family bHLH transcription factor 1 L homeolog	Xenopus laevis	13-18
25712868-7	2015	Impairment of Homer function by introduction of the synthetic PPKKFR peptide into cells, which emulates the proline-rich sequences of the PPXXF motif, or using siRNA Homer1, reduced the association of STIM1 and the Cav1.2 alpha1 subunit.	Proline	108-115	stromal interaction molecule 1	Homo sapiens	201-206
25811613-2	2015	Here, a micellar system employing TfR-specific 7peptide (histidine-alanine-isoleucine-tyrosine- proline-arginine-histidine, HAIYPRH, 7pep) as the targeting moiety was constructed; and its endocytosis, intracellular trafficking as well as influence on TfR expression and in vivo tumor targeting were explored in the MCF-7 tumor model.	Proline	96-103	transferrin receptor	Homo sapiens	34-37
26259481-4	2015	RESULTS: Agp1p can be ubiquitinated on the medium with glutamine, arginine, proline or ammonium.	Proline	76-83	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	9-14
24953863-8	2015	Furthermore, liquid chromatography coupled with tandem mass spectrometry analysis demonstrates that proline residues of the recombinant human collagen alpha1(III) chain were hydroxylated in the X or Y positions of Gly-X-Y triplets.	Proline	100-107	collagen type III alpha 1 chain	Homo sapiens	142-168
25825447-5	2015	This phenotype was due to a lack of signaling through the C-terminal proline-rich motif within host CD28"s cytoplasmic tail, a motif previously shown to be required for development of regulatory T cells (Tregs) and function of conventional T cells.	Proline	69-76	CD28 molecule	Homo sapiens	100-104
25725023-8	2015	Also, genes involved in ergosterol biosynthesis (NSG2) cause improvement of growth at 10 C, dependent on tryptophan uptake, while the gluconeogenesis gene PCK1 and the proline biosynthesis gene PRO2 cause an improvement in growth at 10 C, independent of tryptophan and phosphate uptake.	Proline	168-175	Nsg2p	Saccharomyces cerevisiae S288C	49-53
25731919-6	2015	Several special domains also were found, including a serine-rich domain (SRD) in IRF3, IRF4a, IRF4b, and IRF7; a proline-rich domain (PRD) in IRF9; nuclear localization signals (NLSs) in IRF5, IRF8, and IRF9; and a virus activated domain (VAD) in IRF5.	Proline	113-120	interferon regulatory factor 9	Cynoglossus semilaevis	142-146
25636538-4	2015	Of the 20 MMPs identified, MMP-1, MMP-2, MMP-8, MMP-9, and MMP-12 have been implicated in regulating the matrikines Val-Gly-Val-Ala-Pro-Gly (elastin peptide) and proline-glycine-proline (PGP).	Proline	162-169	matrix metallopeptidase 1	Homo sapiens	10-14
25777973-11	2015	The heterozygous mutation was identified in the third exon of MYOC that revealed a T   C transition at position 1021 (p.S341P), which switched serine (Ser) to proline (Pro).	Proline	159-166	myocilin	Homo sapiens	62-66
25777973-11	2015	The heterozygous mutation was identified in the third exon of MYOC that revealed a T   C transition at position 1021 (p.S341P), which switched serine (Ser) to proline (Pro).	Proline	168-171	myocilin	Homo sapiens	62-66
25636538-4	2015	Of the 20 MMPs identified, MMP-1, MMP-2, MMP-8, MMP-9, and MMP-12 have been implicated in regulating the matrikines Val-Gly-Val-Ala-Pro-Gly (elastin peptide) and proline-glycine-proline (PGP).	Proline	162-169	matrix metallopeptidase 1	Homo sapiens	27-32
25636538-4	2015	Of the 20 MMPs identified, MMP-1, MMP-2, MMP-8, MMP-9, and MMP-12 have been implicated in regulating the matrikines Val-Gly-Val-Ala-Pro-Gly (elastin peptide) and proline-glycine-proline (PGP).	Proline	162-169	matrix metallopeptidase 2	Homo sapiens	34-39
25636538-4	2015	Of the 20 MMPs identified, MMP-1, MMP-2, MMP-8, MMP-9, and MMP-12 have been implicated in regulating the matrikines Val-Gly-Val-Ala-Pro-Gly (elastin peptide) and proline-glycine-proline (PGP).	Proline	162-169	matrix metallopeptidase 8	Homo sapiens	41-46
25636538-4	2015	Of the 20 MMPs identified, MMP-1, MMP-2, MMP-8, MMP-9, and MMP-12 have been implicated in regulating the matrikines Val-Gly-Val-Ala-Pro-Gly (elastin peptide) and proline-glycine-proline (PGP).	Proline	162-169	matrix metallopeptidase 9	Homo sapiens	48-53
25636538-4	2015	Of the 20 MMPs identified, MMP-1, MMP-2, MMP-8, MMP-9, and MMP-12 have been implicated in regulating the matrikines Val-Gly-Val-Ala-Pro-Gly (elastin peptide) and proline-glycine-proline (PGP).	Proline	162-169	matrix metallopeptidase 12	Homo sapiens	59-65
25636538-4	2015	Of the 20 MMPs identified, MMP-1, MMP-2, MMP-8, MMP-9, and MMP-12 have been implicated in regulating the matrikines Val-Gly-Val-Ala-Pro-Gly (elastin peptide) and proline-glycine-proline (PGP).	Proline	162-169	elastin	Homo sapiens	141-148
25733664-0	2015	Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function.	Proline	18-25	apolipoprotein A4	Homo sapiens	44-63
25849135-3	2015	By using mechanism-based screening, here we find that all-trans retinoic acid (ATRA)--a therapy for acute promyelocytic leukemia (APL) that is considered the first example of targeted therapy in cancer, but whose drug target remains elusive--inhibits and degrades active Pin1 selectively in cancer cells by directly binding to the substrate phosphate- and proline-binding pockets in the Pin1 active site.	Proline	356-363	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	271-275
25849135-3	2015	By using mechanism-based screening, here we find that all-trans retinoic acid (ATRA)--a therapy for acute promyelocytic leukemia (APL) that is considered the first example of targeted therapy in cancer, but whose drug target remains elusive--inhibits and degrades active Pin1 selectively in cancer cells by directly binding to the substrate phosphate- and proline-binding pockets in the Pin1 active site.	Proline	356-363	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	387-391
25819436-4	2015	All these interactions depend on a single proline-rich motif in the CTR and the Src-homology 3 domains of the binding partners.	Proline	42-49	calcitonin receptor	Homo sapiens	68-71
25755286-0	2015	Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia.	Proline	43-50	eukaryotic elongation factor 2 kinase	Homo sapiens	0-26
25755286-4	2015	Here, we show that eEF2K is subject to hydroxylation on proline-98.	Proline	56-63	eukaryotic elongation factor 2 kinase	Homo sapiens	19-24
25755286-10	2015	eEF2K is the first example of a protein directly involved in a major energy-consuming process to be regulated by proline hydroxylation.	Proline	113-120	eukaryotic elongation factor 2 kinase	Homo sapiens	0-5
25604990-5	2015	When suffering from drought and salt stresses, lower proline content and much higher MDA content in the TaUBA overexpressors were observed than those of the wild-type control, suggesting TaUBA may function as a negative regulator of salt and drought stress response in plants.	Proline	53-60	protein JOKA2	Triticum aestivum	187-192
25984437-2	2015	In the previous study, we reported that protective effect of proline involves the early activation of IL-6/STAT-3 pathway, an anti-inflammatory and regenerative signaling in the liver.	Proline	61-68	interleukin 6	Homo sapiens	102-106
25984437-2	2015	In the previous study, we reported that protective effect of proline involves the early activation of IL-6/STAT-3 pathway, an anti-inflammatory and regenerative signaling in the liver.	Proline	61-68	signal transducer and activator of transcription 3	Homo sapiens	107-113
25984437-6	2015	Catalase activity was significantly upregulated in proline group from 0 to 3 h after GalN-injection, although GP and GR were downregulated during this period, compared with control group.	Proline	51-58	catalase	Homo sapiens	0-8
25984437-6	2015	Catalase activity was significantly upregulated in proline group from 0 to 3 h after GalN-injection, although GP and GR were downregulated during this period, compared with control group.	Proline	51-58	glutathione-disulfide reductase	Homo sapiens	117-119
25984437-8	2015	Consistently with this, at 6 h, the GR activity in the proline group was significantly higher, followed with the higher tendency of GP activity at 12 h. Catalase activity was also significantly higher at 12 h. Taken together, catalase was activated at the beginning, followed with the significant activation of glutathione redox system around 6 to 12 h in proline group.	Proline	55-62	glutathione-disulfide reductase	Homo sapiens	36-38
25984437-8	2015	Consistently with this, at 6 h, the GR activity in the proline group was significantly higher, followed with the higher tendency of GP activity at 12 h. Catalase activity was also significantly higher at 12 h. Taken together, catalase was activated at the beginning, followed with the significant activation of glutathione redox system around 6 to 12 h in proline group.	Proline	55-62	catalase	Homo sapiens	226-234
25733664-6	2015	Here we show that the systematic conversion of these prolines to alanine increased the thermodynamic stability of apoA-IV and its propensity to oligomerize.	Proline	53-61	apolipoprotein A4	Homo sapiens	114-121
25984437-8	2015	Consistently with this, at 6 h, the GR activity in the proline group was significantly higher, followed with the higher tendency of GP activity at 12 h. Catalase activity was also significantly higher at 12 h. Taken together, catalase was activated at the beginning, followed with the significant activation of glutathione redox system around 6 to 12 h in proline group.	Proline	356-363	glutathione-disulfide reductase	Homo sapiens	36-38
25984437-8	2015	Consistently with this, at 6 h, the GR activity in the proline group was significantly higher, followed with the higher tendency of GP activity at 12 h. Catalase activity was also significantly higher at 12 h. Taken together, catalase was activated at the beginning, followed with the significant activation of glutathione redox system around 6 to 12 h in proline group.	Proline	356-363	catalase	Homo sapiens	153-161
25984437-8	2015	Consistently with this, at 6 h, the GR activity in the proline group was significantly higher, followed with the higher tendency of GP activity at 12 h. Catalase activity was also significantly higher at 12 h. Taken together, catalase was activated at the beginning, followed with the significant activation of glutathione redox system around 6 to 12 h in proline group.	Proline	356-363	catalase	Homo sapiens	226-234
25747289-2	2015	The expression of four genes, involved in sucrose metabolism (SPS and SuSy), biosynthesis of galactinol (GoLS1) and proline accumulation (P5CS) was compared: at meiosis (MM), vacuolated and mature stages of pollen development in heat tolerant and heat sensitive tomato genotypes.	Proline	116-123	delta-1-pyrroline-5-carboxylate synthase	Solanum lycopersicum	138-142
25815792-11	2015	Our results suggest that presence of multiple complexes of heterocycles forming by tryptophan and proline residues in tripeptides is crucial for their tight binding to Abeta fibrils as well as for extensive fibril depolymerization.	Proline	98-105	amyloid beta precursor protein	Homo sapiens	168-173
25848013-2	2015	Particularly abundant, yet so far undruggable, targets include domains specialized in recognizing proline-rich segments, including Src-homology 3 (SH3), WW, GYF, and Drosophila enabled (Ena)/vasodilator-stimulated phosphoprotein (VASP) homology 1 (EVH1) domains.	Proline	98-105	vasodilator stimulated phosphoprotein	Homo sapiens	230-234
25909858-9	2015	Complementation of the yeast npr1Delta mutant with each of the three F. fujikuroi NPR1 homologues, resulted in partial restoration of ammonium, arginine and proline uptake by FfNPR1-1 while none of the three kinases affect growth on different nitrogen sources and nitrogen-dependent sorting of FfGap1 in F. fujikuroi.	Proline	157-164	serine/threonine protein kinase NPR1	Saccharomyces cerevisiae S288C	82-86
25603287-2	2015	We demonstrate that Cdk1-cyclin B, the central mitotic kinase, is specific for the trans conformation, not cis, of synthetic, locked Ser-Pro 11-residue peptide substrates, using LC-MSMS detection and sequencing of phosphorylated products.	Proline	137-140	cyclin dependent kinase 1	Homo sapiens	20-24
25406896-4	2015	We find that the pharmacological chaperone O4, the chemical chaperone proline as well as the protein chaperone serum amyloid P component (SAP) are inhibitors of the type 2 diabetes mellitus-related aggregation process of islet amyloid polypeptide (IAPP).	Proline	70-77	islet amyloid polypeptide	Homo sapiens	248-252
25818297-1	2015	Proline-directed phosphorylation is regulated by the prolyl isomerase Pin1, which plays a fundamental role in driving breast cancer stem-like cells (BCSCs).	Proline	0-7	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	70-74
25831499-12	2015	Pin1 acts via isomerization of proline side chains at phosphorylated PDPK motifs, thereby affecting substrate conformation and activity.	Proline	31-38	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
25849367-3	2015	An isoleucine-to-proline change (I559P) in the gp41 ectodomain has been used to stabilize soluble forms of HIV-1 Env trimers for structural characterization and for use as immunogens.	Proline	17-24	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	113-116
25849367-7	2015	Nonetheless, regardless of the presence of the SOS changes, Envs with proline 559 were recognized less efficiently than Envs with isoleucine 559 by the VRC01 neutralizing antibody, which binds the CD4-binding site of gp120, and the PGT151 neutralizing antibody, which binds a hybrid gp120-gp41 epitope.	Proline	70-77	CD4 molecule	Homo sapiens	197-200
25849367-7	2015	Nonetheless, regardless of the presence of the SOS changes, Envs with proline 559 were recognized less efficiently than Envs with isoleucine 559 by the VRC01 neutralizing antibody, which binds the CD4-binding site of gp120, and the PGT151 neutralizing antibody, which binds a hybrid gp120-gp41 epitope.	Proline	70-77	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	217-222
25534429-1	2015	Sodium-dependent neutral amino acid transporter B(0)AT1 (SLC6A19) and imino acid (proline) transporter SIT1 (SLC6A20) are expressed at the luminal membrane of small intestine enterocytes and proximal tubule kidney cells where they exert key functions for amino acid (re)absorption as documented by their role in Hartnup disorder and iminoglycinuria, respectively.	Proline	82-89	signaling threshold regulating transmembrane adaptor 1	Homo sapiens	103-107
25534429-1	2015	Sodium-dependent neutral amino acid transporter B(0)AT1 (SLC6A19) and imino acid (proline) transporter SIT1 (SLC6A20) are expressed at the luminal membrane of small intestine enterocytes and proximal tubule kidney cells where they exert key functions for amino acid (re)absorption as documented by their role in Hartnup disorder and iminoglycinuria, respectively.	Proline	82-89	solute carrier family 6 member 20	Homo sapiens	109-116
25761918-9	2015	The other histatins and acidic proline-rich proteins encoded by PRH1 locus appeared in whole saliva of babies from 1 to 3 weeks after the normal term of delivery, S-type cystatins appeared at 1 year (+-3 months), and basic proline-rich proteins appeared at 4 years (+-1 year) of age.	Proline	31-38	proline rich protein HaeIII subfamily 1	Homo sapiens	64-68
25761918-9	2015	The other histatins and acidic proline-rich proteins encoded by PRH1 locus appeared in whole saliva of babies from 1 to 3 weeks after the normal term of delivery, S-type cystatins appeared at 1 year (+-3 months), and basic proline-rich proteins appeared at 4 years (+-1 year) of age.	Proline	223-230	proline rich protein HaeIII subfamily 1	Homo sapiens	64-68
25905034-1	2015	Eukaryotic aminopeptidase P1 (APP1), also known as X-prolyl aminopeptidase (XPNPEP1) in human tissues, is a cytosolic exopeptidase that preferentially removes amino acids from the N-terminus of peptides possessing a penultimate N-terminal proline residue.	Proline	239-246	X-prolyl aminopeptidase 1	Homo sapiens	30-34
25905034-1	2015	Eukaryotic aminopeptidase P1 (APP1), also known as X-prolyl aminopeptidase (XPNPEP1) in human tissues, is a cytosolic exopeptidase that preferentially removes amino acids from the N-terminus of peptides possessing a penultimate N-terminal proline residue.	Proline	239-246	X-prolyl aminopeptidase 1	Homo sapiens	76-83
25683338-0	2015	Structural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase II.	Proline	36-43	carbonic anhydrase 2	Homo sapiens	120-141
25655327-4	2015	Structural analysis showed that bcMAVS is composed of functional domains including an N-terminal CARD, a central proline-rich domain, a putative TRAF2-binding motif and a C-terminal TM domain, which is similar to mammalian MAVS.	Proline	113-120	mitochondrial antiviral signaling protein	Homo sapiens	34-38
25727410-2	2015	Among several prophylactic molecules proven suitable for ameliorating free radical damage, NAP (an octapeptide with initial amino acids: asparagine/N, alanine/A, and proline/P) can be considered superlative, primarily due to its high permeability into brain through blood-brain barrier and observed activity at femtomolar concentrations.	Proline	166-173	catenin, beta like 1	Rattus norvegicus	91-94
25683338-2	2015	This study emphasizes the effect of increasing the rigidity of human carbonic anhydrase II (HCA II; EC 4.2.1.1) via incorporation of proline residues at positions 170 and 234, which are located in surface loops that are able to accommodate restrictive main-chain conformations without rearrangement of the surrounding peptide backbone.	Proline	133-140	carbonic anhydrase 2	Homo sapiens	69-90
25628064-5	2015	This interaction is particularly important given the numerous proline-directed phosphorylation sites found on tau and the role phosphorylation has been found to play in pathogenesis.	Proline	62-69	microtubule associated protein tau	Homo sapiens	110-113
26020189-6	2015	Proline treatment decreased plasma D-lactate concentration but increased the villus height in the jejunum and ileum, as well as the percentage of proliferating cell nuclear antigen (PCNA) positive cells and alkaline phosphatase (AKP) activity in the jejunal mucosa (P &lt; 0.05).	Proline	0-7	proliferating cell nuclear antigen	Homo sapiens	146-180
26020189-6	2015	Proline treatment decreased plasma D-lactate concentration but increased the villus height in the jejunum and ileum, as well as the percentage of proliferating cell nuclear antigen (PCNA) positive cells and alkaline phosphatase (AKP) activity in the jejunal mucosa (P &lt; 0.05).	Proline	0-7	proliferating cell nuclear antigen	Homo sapiens	182-186
26020189-7	2015	The protein expressions for zonula occludens (ZO-1), occludin, and claudin-3 (P &lt; 0.05) but not mRNA were increased in the jejunum of putrescine- and proline-treated piglets compared with those of control piglets.	Proline	153-160	claudin 3	Homo sapiens	67-76
26020189-8	2015	The voltage-gated K+ channel (Kv) 1.1 protein expression in the jejunum of piglets administrated with putrescine and the Kv1.5 mRNA and Kv1.1 protein levels in the ileum of piglets administrated with proline were greater than those in control piglets (P &lt; 0.05).	Proline	200-207	potassium voltage-gated channel subfamily A member 1	Homo sapiens	4-37
26020189-8	2015	The voltage-gated K+ channel (Kv) 1.1 protein expression in the jejunum of piglets administrated with putrescine and the Kv1.5 mRNA and Kv1.1 protein levels in the ileum of piglets administrated with proline were greater than those in control piglets (P &lt; 0.05).	Proline	200-207	potassium voltage-gated channel subfamily A member 5	Homo sapiens	121-126
25703206-2	2015	In an effort to test the generality of this hypothesis, we have undertaken here a detailed biophysical analysis of the binding of WW domains of WWOX alone and in the context of the WW1-WW2 tandem module to an array of putative proline-proline-x-tyrosine (PPXY) ligands.	Proline	227-234	WW domain containing oxidoreductase	Homo sapiens	144-148
25831123-5	2015	CDK5 is a proline-directed serine/threonine kinase historically linked to neural development and injury.	Proline	10-17	cyclin-dependent kinase 5	Mus musculus	0-4
25576397-1	2015	The unique proline isomerase Pin1 is pivotal for protecting against age-dependent neurodegeneration in Alzheimer"s disease (AD), with its inhibition providing a molecular link between tangle and plaque pathologies.	Proline	11-18	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	29-33
25645914-4	2015	Fundamentally, it is understood that P3H1 is responsible for converting proline to 3-hydroxyproline.	Proline	72-79	prolyl 3-hydroxylase 1	Mus musculus	37-41
25636406-7	2015	Furthermore, these differences hinge on proline 8, which is conserved in CCL3 and CCL4 but is replaced by lysine in human CCL18.	Proline	40-47	C-C motif chemokine ligand 3	Homo sapiens	73-77
25636406-7	2015	Furthermore, these differences hinge on proline 8, which is conserved in CCL3 and CCL4 but is replaced by lysine in human CCL18.	Proline	40-47	C-C motif chemokine ligand 4	Homo sapiens	82-86
25636406-7	2015	Furthermore, these differences hinge on proline 8, which is conserved in CCL3 and CCL4 but is replaced by lysine in human CCL18.	Proline	40-47	C-C motif chemokine ligand 18	Homo sapiens	122-127
25743213-4	2015	Isothiocyanates inhibit MIF tautomerase activity via covalent modification of the N-terminal proline.	Proline	93-100	macrophage migration inhibitory factor	Homo sapiens	24-27
25811192-9	2015	"Proline" of GxP motif (Pro386 of NOD1 and Pro464 of NOD2) interacted with adenine moiety and His511 at Sensor 2 of NOD1 interacted with gamma-phosphate group of ATP.	Proline	1-8	nucleotide-binding oligomerization domain containing 1	Danio rerio	34-38
25816339-4	2015	Substitution of the serine at position 197 in the middle of the cleavage region for a proline (S197P) effectively blocked CD16a and CD16b cleavage in cell-based assays.	Proline	86-93	Fc gamma receptor IIIa	Homo sapiens	122-127
25816339-4	2015	Substitution of the serine at position 197 in the middle of the cleavage region for a proline (S197P) effectively blocked CD16a and CD16b cleavage in cell-based assays.	Proline	86-93	Fc gamma receptor IIIb	Homo sapiens	132-137
25811192-9	2015	"Proline" of GxP motif (Pro386 of NOD1 and Pro464 of NOD2) interacted with adenine moiety and His511 at Sensor 2 of NOD1 interacted with gamma-phosphate group of ATP.	Proline	1-8	nucleotide-binding oligomerization domain containing 2	Danio rerio	53-57
25811192-9	2015	"Proline" of GxP motif (Pro386 of NOD1 and Pro464 of NOD2) interacted with adenine moiety and His511 at Sensor 2 of NOD1 interacted with gamma-phosphate group of ATP.	Proline	1-8	nucleotide-binding oligomerization domain containing 1	Danio rerio	116-120
25789479-3	2015	Prior studies have shown that cytoplasmic proline, glutamic acid and leucine rich protein 1 (PELP1) promotes Tam resistance in breast cancer cell lines.	Proline	42-49	proline, glutamate and leucine rich protein 1	Homo sapiens	93-98
26064201-1	2015	BACKGROUND: The polymorphism of TP53 codon 72, a transversion of G to C (Arg to Pro), has been demonstrated to be associated with the risk for lung cancer.	Proline	80-83	tumor protein p53	Homo sapiens	32-36
25398946-2	2015	ALS-linked mutations in UBQLN2 are clustered in a unique proline-X-X repeat region, reportedly leading to impairment of the ubiquitin proteasome system.	Proline	57-64	ubiquilin 2	Homo sapiens	24-30
26005532-0	2015	Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement.	Proline	22-29	coagulation factor II	Rattus norvegicus	45-53
25586189-7	2015	This interaction depends on the N-terminal proline-rich domains of SH2B1.	Proline	43-50	SH2B adaptor protein 1	Homo sapiens	67-72
25572393-4	2015	We demonstrate that l-proline is recognized by PrnB via interactions with residues within TMS1 (Gly(56), Thr(57)), TMS3 (Glu(138)), and TMS6 (Phe(248)), which are evolutionary conserved in YATs, whereas specificity is achieved by subtle amino acid substitutions in variable residues.	Proline	20-29	Tms1p	Saccharomyces cerevisiae S288C	90-94
25572393-5	2015	Put4p-mimicking substitutions in TMS3 (S130C), TMS6 (F252L, S253G), TMS8 (W351F), and TMS10 (T414S) broadened the specificity of PrnB, enabling it to recognize more efficiently l-alanine, l-azetidine-2-carboxylic acid, and glycine without significantly affecting the apparent Km for l-proline.	Proline	283-292	proline permease PUT4	Saccharomyces cerevisiae S288C	0-5
25280783-1	2015	The prolyl isomerase Pin1, which isomerizes the p-Ser/Thr-Pro peptide bonds and effects conformational and functional changes of the bound proteins, has been identified as a regulator of phosphorylation signaling in several diseases including cancer.	Proline	58-61	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	21-25
25529026-0	2015	Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function.	Proline	10-17	RNA binding protein with serine rich domain 1	Homo sapiens	53-63
25529026-4	2015	In the present study, we address the effects of discrete serine-proline phosphorylation on the conformation and cellular function of the SR protein SRSF1 (SR protein splicing factor 1).	Proline	64-71	RNA binding protein with serine rich domain 1	Homo sapiens	137-147
25529026-4	2015	In the present study, we address the effects of discrete serine-proline phosphorylation on the conformation and cellular function of the SR protein SRSF1 (SR protein splicing factor 1).	Proline	64-71	serine and arginine rich splicing factor 1	Homo sapiens	148-153
25529026-4	2015	In the present study, we address the effects of discrete serine-proline phosphorylation on the conformation and cellular function of the SR protein SRSF1 (SR protein splicing factor 1).	Proline	64-71	serine and arginine rich splicing factor 1	Homo sapiens	155-183
25529026-5	2015	Using chemical tagging and dephosphorylation experiments, we show that modification of serine-proline dipeptides broadly amplifies the conformational ensemble of SRSF1.	Proline	94-101	serine and arginine rich splicing factor 1	Homo sapiens	162-167
25663649-4	2015	Here, we explored the minimal structural requirement for a scaffold protein by coupling multiple copies of a proline-rich peptide corresponding to an interaction motif for the SH3 domain of the adaptor protein GADS to an N-(2-hydroxypropyl)methacrylamide polymer backbone.	Proline	109-116	GRB2 related adaptor protein 2	Homo sapiens	210-214
25502926-0	2015	Molecular cloning and expression analysis of the gene encoding proline dehydrogenase from Jatropha curcas L. Proline dehydrogenase (ProDH) (EC 1.5.99.8) is a key enzyme in the catabolism of proline.	Proline	63-70	proline dehydrogenase 1, mitochondrial	Jatropha curcas	109-130
25502926-0	2015	Molecular cloning and expression analysis of the gene encoding proline dehydrogenase from Jatropha curcas L. Proline dehydrogenase (ProDH) (EC 1.5.99.8) is a key enzyme in the catabolism of proline.	Proline	63-70	proline dehydrogenase 1, mitochondrial	Jatropha curcas	132-137
25502926-7	2015	The JcProDH protein was successfully expressed in the yeast strain INVSc1 and showed high enzyme activity in proline catabolism.	Proline	109-116	proline dehydrogenase 1, mitochondrial	Jatropha curcas	4-11
25363567-1	2015	A "double-hydrophobic" elastin-like triblock polypeptide GPG has been constructed by mimicking the localization of proline- and glycine-rich hydrophobic domains of native elastin, a protein that provides elasticity and resilience to connective tissues.	Proline	115-122	elastin	Homo sapiens	23-30
25363567-1	2015	A "double-hydrophobic" elastin-like triblock polypeptide GPG has been constructed by mimicking the localization of proline- and glycine-rich hydrophobic domains of native elastin, a protein that provides elasticity and resilience to connective tissues.	Proline	115-122	elastin	Homo sapiens	171-178
25445907-3	2015	The putative MAVS_tv1 protein (full length form) contains an N-terminal CARD domain, a central proline region, and a C-terminal transmembrane domain (TM).	Proline	95-102	mitochondrial antiviral signaling protein	Danio rerio	13-17
25226867-7	2015	TP53 sequence analysis of the index patient revealed the germline mutation c.1025G &gt; C in a heterozygous state, resulting in an amino acid exchange from arginine to proline (p.Arg342Pro) in the tetramerization domain of p53.	Proline	168-175	tumor protein p53	Homo sapiens	0-4
25226867-7	2015	TP53 sequence analysis of the index patient revealed the germline mutation c.1025G &gt; C in a heterozygous state, resulting in an amino acid exchange from arginine to proline (p.Arg342Pro) in the tetramerization domain of p53.	Proline	168-175	tumor protein p53	Homo sapiens	223-226
25540435-5	2015	Compared with the wild type, the dsptp1 mutant shows increased proline accumulation, reduced malondialdehyde (MDA) content and ion leakage, and enhanced antioxidant enzyme activity in response to osmotic stress.	Proline	63-70	dual specificity protein phosphatase 1	Arabidopsis thaliana	33-39
25691319-2	2015	Deficiency of prolidase leads to the increased excretion of proline in urine, which causes impaired collagen synthesis and delay in wound healing.	Proline	60-67	peptidase D	Homo sapiens	14-23
25187260-1	2015	Pin1 is a peptidyl prolyl cis-trans isomerase that specifically binds to the phosphoserine-proline or phosphothreonine-proline motifs of numerous proteins.	Proline	91-98	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
25187260-1	2015	Pin1 is a peptidyl prolyl cis-trans isomerase that specifically binds to the phosphoserine-proline or phosphothreonine-proline motifs of numerous proteins.	Proline	119-126	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
25633201-2	2015	In the work reported herein, we interrogated the amyloidogenesis mechanism of human beta2-microglobulin (beta2m), which is thought to be triggered by a pivotal cis-trans isomerization of a proline residue at position 32 in the polypeptide, with nonstandard amino acids.	Proline	189-196	beta-2-microglobulin	Homo sapiens	84-103
25480797-6	2015	Plasma AA concentration was decreased in Slc43a2 null pups, in particular that of non-essential AAs alanine, serine, histidine and proline.	Proline	131-138	solute carrier family 43, member 2	Mus musculus	41-48
25663877-5	2015	In addition, a G A mutation at nucleotide 7997 within exon 10 of the MEN1 gene was identified; the mutation was synonymous, therefore, the proline at amino acid 590 of the menin protein (P590P) did not change.	Proline	139-146	menin 1	Homo sapiens	69-73
25663877-5	2015	In addition, a G A mutation at nucleotide 7997 within exon 10 of the MEN1 gene was identified; the mutation was synonymous, therefore, the proline at amino acid 590 of the menin protein (P590P) did not change.	Proline	139-146	menin 1	Homo sapiens	172-177
25872475-8	2015	The disease regulated network proteins were mapped to distinct pathways and bioinformatics provided novel insight into molecular circuits associated with significant changes in either glycolysis and gluconeogenesis, argine and proline metabolism, protein processing in endoplasmic reticulum, Hif- and MAPK signalling, lipoprotein metabolism, platelet activation and hemostatic control as a result of aberrant EGF signalling.	Proline	227-234	epidermal growth factor	Homo sapiens	409-412
25633201-2	2015	In the work reported herein, we interrogated the amyloidogenesis mechanism of human beta2-microglobulin (beta2m), which is thought to be triggered by a pivotal cis-trans isomerization of a proline residue at position 32 in the polypeptide, with nonstandard amino acids.	Proline	189-196	beta-2-microglobulin	Homo sapiens	105-111
25702031-0	2015	Dynamical role of phosphorylation on serine/threonine-proline Pin1 substrates from constant force molecular dynamics simulations.	Proline	54-61	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	62-66
25659156-6	2015	In particular, RanBPM comprises two motifs that can confer nuclear localization, one proline/glutamine-rich motif in the extreme N-terminus which has a dominant effect on RanBPM localization, and a second motif in the C-terminus which minimally contributes to RanBPM nuclear targeting.	Proline	85-92	RAN binding protein 9	Homo sapiens	15-21
25596127-5	2015	Following drought stress there were higher nitrogen and proline contents in transgenic AtTGA4 plants than in wild type controls, and activity of the key enzyme nitrite reductase (NIR) involved in nitrate assimilation processes was also higher.	Proline	56-63	TGACG motif-binding factor 4	Arabidopsis thaliana	87-93
25643626-7	2015	Serine, proline, or histidine-mediated lifespan extension was greatly inhibited in eat-2 worms, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ribosomal S6 kinase), gcn-2, and aak-2 (AMPK) longevity pathway mutants, and in bec-1 autophagy-defective knockdown worms.	Proline	8-15	Neuronal acetylcholine receptor subunit eat-2	Caenorhabditis elegans	83-88
25667979-2	2015	Most known ALG-2-interacting proteins contain proline-rich regions in which either PPYPXnYP (type 1 motif) or PXPGF (type 2 motif) is commonly found.	Proline	46-53	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	11-16
25643626-7	2015	Serine, proline, or histidine-mediated lifespan extension was greatly inhibited in eat-2 worms, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ribosomal S6 kinase), gcn-2, and aak-2 (AMPK) longevity pathway mutants, and in bec-1 autophagy-defective knockdown worms.	Proline	8-15	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	131-137
25643626-7	2015	Serine, proline, or histidine-mediated lifespan extension was greatly inhibited in eat-2 worms, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ribosomal S6 kinase), gcn-2, and aak-2 (AMPK) longevity pathway mutants, and in bec-1 autophagy-defective knockdown worms.	Proline	8-15	Ribosomal protein S6 kinase beta	Caenorhabditis elegans	153-159
25490603-0	2015	Proline functionalization of the mesoporous metal-organic framework DUT-32.	Proline	0-7	deoxyuridine triphosphatase	Homo sapiens	68-71
25490603-2	2015	When 4,4"-biphenyldicarboxylic acid was replaced with a Boc-protected proline-functionalized linker (H(2)L) in the synthesis of DUT-32 (DUT = Dresden University of Technology), a highly porous enantiomerically pure MOF (DUT-32-NHProBoc) was obtained, as could be confirmed by enantioselective high-performance liquid chromatography (HPLC) measurements and solid-state NMR experiments.	Proline	70-77	deoxyuridine triphosphatase	Homo sapiens	128-131
25556092-2	2015	Through a ligand-based pharmacophore model (S)-proline based compounds were identified as potent cannabinoid receptor 2 (CB2) agonists with high selectivity over the cannabinoid receptor 1 (CB1).	Proline	43-54	cannabinoid receptor 2	Homo sapiens	97-119
25594676-0	2015	Proline-catalyzed sequential syn-Mannich and [4 + 1]-annulation cascade reactions to form densely functionalized pyrrolidines.	Proline	0-7	synemin	Homo sapiens	29-32
25594676-2	2015	The in situ generated syn-Mannich adduct obtained via proline catalysis acts as a four-atom component, and Corey"s sulfur ylide or ethyl bromoacetate acts as a one-atom carbon source to construct pyrrolidine units in a highly enantio- and diastereoselective manner.	Proline	54-61	synemin	Homo sapiens	22-25
25556092-2	2015	Through a ligand-based pharmacophore model (S)-proline based compounds were identified as potent cannabinoid receptor 2 (CB2) agonists with high selectivity over the cannabinoid receptor 1 (CB1).	Proline	43-54	cannabinoid receptor 2	Homo sapiens	121-124
25556098-4	2015	Specifically, compounds containing azetidine-, proline-, and piperidine-based cores were found to have low nanomolar and picomolar CB2 agonist activities with drug-like properties considered appropriate for early profiling.	Proline	47-54	cannabinoid receptor 2	Homo sapiens	131-134
25556092-2	2015	Through a ligand-based pharmacophore model (S)-proline based compounds were identified as potent cannabinoid receptor 2 (CB2) agonists with high selectivity over the cannabinoid receptor 1 (CB1).	Proline	43-54	cannabinoid receptor 1	Homo sapiens	166-188
25556092-2	2015	Through a ligand-based pharmacophore model (S)-proline based compounds were identified as potent cannabinoid receptor 2 (CB2) agonists with high selectivity over the cannabinoid receptor 1 (CB1).	Proline	43-54	cannabinoid receptor 1	Homo sapiens	190-193
25838788-0	2015	An IMS-IMS threshold method for semi-quantitative determination of activation barriers: Interconversion of proline cis trans forms in triply protonated bradykinin.	Proline	107-114	kininogen 1	Homo sapiens	152-162
25274777-2	2015	We examined the mechanism behind autosomal dominant cone-rod dystrophy (adCORD) caused by 12 base pair (bp) deletion at proline 351 of hAIPL1 (P351Delta12) mutation in the primate-specific region of human AIPL1.	Proline	120-127	aryl hydrocarbon receptor interacting protein like 1	Homo sapiens	135-141
25274777-2	2015	We examined the mechanism behind autosomal dominant cone-rod dystrophy (adCORD) caused by 12 base pair (bp) deletion at proline 351 of hAIPL1 (P351Delta12) mutation in the primate-specific region of human AIPL1.	Proline	120-127	aryl hydrocarbon receptor interacting protein like 1	Homo sapiens	136-141
24853881-0	2015	Progesterone regulation of tissue factor depends on MEK1/2 activation and requires the proline-rich site on progesterone receptor.	Proline	87-94	coagulation factor III, tissue factor	Homo sapiens	27-40
24853881-0	2015	Progesterone regulation of tissue factor depends on MEK1/2 activation and requires the proline-rich site on progesterone receptor.	Proline	87-94	progesterone receptor	Homo sapiens	108-129
24853881-8	2015	TF mRNA upregulation requires an intact PR proline-rich site (mPRO), but it is independent from c-Src.	Proline	43-50	coagulation factor III, tissue factor	Homo sapiens	0-2
24853881-8	2015	TF mRNA upregulation requires an intact PR proline-rich site (mPRO), but it is independent from c-Src.	Proline	43-50	progesterone receptor	Homo sapiens	40-42
25527290-10	2015	However, nuclear Gat1 localization, which also exhibits a glutamine tRNACUG requirement for its response to short-term nitrogen starvation or growth in proline medium or a ure2Delta mutation, does not require tRNACUG for its response to rapamycin.	Proline	152-159	Gat1p	Saccharomyces cerevisiae S288C	17-21
25261582-2	2015	The tumour-suppressor p53 protein presents a proline-rich region that is crucial for regulating apoptosis by connecting the p53 with a complex protein network.	Proline	45-52	tumor protein p53	Homo sapiens	22-25
25261582-2	2015	The tumour-suppressor p53 protein presents a proline-rich region that is crucial for regulating apoptosis by connecting the p53 with a complex protein network.	Proline	45-52	tumor protein p53	Homo sapiens	124-127
25261582-5	2015	In this article, we analyse the binding of the p53 proline-rich region with a pool of selected polyproline binding domains (i.e. SH3 and WW), and we present the first demonstration that the purified SH3 domains of the CD2AP/Cin85 protein family are able to directly bind the p53 protein, and to discriminate between the two polymorphic variants P72R.	Proline	51-58	tumor protein p53	Homo sapiens	47-50
25428995-8	2015	In leaves of the SXD1:RNAi plants, sodium accumulation was diminished, while proline accumulation and pools of soluble antioxidants were increased.	Proline	77-84	tocopherol cyclase	Solanum tuberosum	17-21
25256710-2	2015	Several genetic polymorphisms exist in TP53, including a proline to arginine variant at amino acid 72 (P72 and R72, respectively); this polymorphism alters p53 function.	Proline	57-64	tumor protein p53	Homo sapiens	39-43
25539813-7	2015	We also identified Vav1 as the linker molecule that couples the C-terminal proline-rich motif of CD28 to the recruitment and activation of PIP5Kalpha, which in turn cooperates with Vav1 in regulating actin polymerization and CD28 signaling functions.	Proline	75-82	vav guanine nucleotide exchange factor 1	Homo sapiens	19-23
25539813-7	2015	We also identified Vav1 as the linker molecule that couples the C-terminal proline-rich motif of CD28 to the recruitment and activation of PIP5Kalpha, which in turn cooperates with Vav1 in regulating actin polymerization and CD28 signaling functions.	Proline	75-82	CD28 molecule	Homo sapiens	97-101
25539813-7	2015	We also identified Vav1 as the linker molecule that couples the C-terminal proline-rich motif of CD28 to the recruitment and activation of PIP5Kalpha, which in turn cooperates with Vav1 in regulating actin polymerization and CD28 signaling functions.	Proline	75-82	CD28 molecule	Homo sapiens	225-229
25410852-2	2015	The binding involved the 106-to-131 domain, corresponding to the dimerization domain of P and the C-terminal domain of FAK containing the proline-rich domains PRR2 and PRR3.	Proline	138-145	protein tyrosine kinase 2	Homo sapiens	119-122
25410852-2	2015	The binding involved the 106-to-131 domain, corresponding to the dimerization domain of P and the C-terminal domain of FAK containing the proline-rich domains PRR2 and PRR3.	Proline	138-145	proline rich nuclear receptor coactivator 1	Homo sapiens	159-163
25256710-2	2015	Several genetic polymorphisms exist in TP53, including a proline to arginine variant at amino acid 72 (P72 and R72, respectively); this polymorphism alters p53 function.	Proline	57-64	DEAD-box helicase 17	Homo sapiens	103-106
25256710-2	2015	Several genetic polymorphisms exist in TP53, including a proline to arginine variant at amino acid 72 (P72 and R72, respectively); this polymorphism alters p53 function.	Proline	57-64	tumor protein p53	Homo sapiens	156-159
25621052-2	2015	The aim of the present study was to determine if the phosphorylated proline-rich Akt substrate of 40 kDa (phospho-PRAS40Thr246), a novel biomarker for phosphoinositol-3 kinase (PI3K) pathway activation, could predict the response of HER2-positive metastatic breast cancers to treatment with trastuzumab.	Proline	68-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	233-237
25852448-2	2015	The RUNX2 gene consists of a glutamine and alanine repeat domain (Q/A domain, 23Q/17A), a DNA-binding Runt domain and a proline/serine/threonine-rich domain.	Proline	120-127	RUNX family transcription factor 2	Homo sapiens	4-9
25447237-2	2015	Most disease-associated mutations are located in the C-terminal proline-tyrosine nuclear localization sequence (PY-NLS) of FUS and impair its nuclear import.	Proline	64-71	FUS RNA binding protein	Homo sapiens	123-126
25604483-0	2015	Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2.	Proline	30-33	cyclin dependent kinase 1	Homo sapiens	55-59
25371203-1	2015	Thyrotropin-releasing hormone is a tripeptide that consists of 5-oxoproline, histidine, and proline.	Proline	68-75	thyrotropin releasing hormone	Homo sapiens	0-29
25519989-6	2015	Intriguingly, however, Shp2"s PTP domain does contain a cysteine residue (C333) at a position that is removed from the active site and is occupied by proline in other classical PTPs.	Proline	150-157	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	23-27
25604483-0	2015	Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2.	Proline	30-33	epithelial cell transforming 2	Homo sapiens	131-135
25604483-1	2015	The cyclin B-dependent protein kinase Cdk1 is a master regulator of mitosis and phosphorylates numerous proteins on the minimal consensus motif Ser/Thr-Pro (S/T-P).	Proline	152-155	cyclin dependent kinase 1	Homo sapiens	38-42
25392210-6	2015	Within human SCR2, replacement of serine 104 (S104) with the proline residue found in murine DAF eliminated virus binding.	Proline	61-68	CD55 molecule, decay accelerating factor for complement	Mus musculus	93-96
25595103-11	2015	Docking of orphan human cytochrome P450 4X1 with arachidonic acid revealed that TYR 112, ALA 126, ILE 222, ILE 223, THR 312, LEU 315, ALA 316, ASP 319, THR 320, PHE 491 and ILE 492 residues were actively participating in the interaction, while docking of CYP4X1 with anandamide showed that TYR 112, GLN 114, PRO 118, ALA 126, ILE 222, ILE 223, SER 251, LEU 315, ALA 316 and PHE 491 key residues were involved in strong interaction.	Proline	308-311	cytochrome P450 family 4 subfamily X member 1	Homo sapiens	24-43
25628629-0	2014	Involvement of Phosphatidylinositol 3-kinase in the regulation of proline catabolism in Arabidopsis thaliana.	Proline	66-73	vacuolar protein sorting 34	Arabidopsis thaliana	15-44
25467137-2	2015	The phosphorylation of threonine 231 preceding proline 232 (pThr231-Pro232) triggers tau hyperphosphorylation, tau aggregation, and tau pathology.	Proline	47-54	prostate stem cell antigen	Homo sapiens	68-74
25467137-2	2015	The phosphorylation of threonine 231 preceding proline 232 (pThr231-Pro232) triggers tau hyperphosphorylation, tau aggregation, and tau pathology.	Proline	47-54	microtubule associated protein tau	Homo sapiens	85-88
25467137-2	2015	The phosphorylation of threonine 231 preceding proline 232 (pThr231-Pro232) triggers tau hyperphosphorylation, tau aggregation, and tau pathology.	Proline	47-54	microtubule associated protein tau	Homo sapiens	111-114
25467137-2	2015	The phosphorylation of threonine 231 preceding proline 232 (pThr231-Pro232) triggers tau hyperphosphorylation, tau aggregation, and tau pathology.	Proline	47-54	microtubule associated protein tau	Homo sapiens	111-114
25628629-6	2014	In this study, we demonstrate that proline metabolism is also regulated by class-III Phosphatidylinositol 3-kinase (PI3K), VPS34, which catalyses the formation of phosphatidylinositol 3-phosphate (PI3P) from phosphatidylinositol.	Proline	35-42	vacuolar protein sorting 34	Arabidopsis thaliana	85-114
25628629-6	2014	In this study, we demonstrate that proline metabolism is also regulated by class-III Phosphatidylinositol 3-kinase (PI3K), VPS34, which catalyses the formation of phosphatidylinositol 3-phosphate (PI3P) from phosphatidylinositol.	Proline	35-42	vacuolar protein sorting 34	Arabidopsis thaliana	123-128
25628629-8	2014	The lower proline accumulation is correlated with a lower transcript level of Pyrroline-5-carboxylate synthetase 1 (P5CS1) biosynthetic enzyme and higher transcript and protein levels of Proline dehydrogenase 1 (ProDH1), a key-enzyme in proline catabolism.	Proline	10-17	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	78-114
25628629-8	2014	The lower proline accumulation is correlated with a lower transcript level of Pyrroline-5-carboxylate synthetase 1 (P5CS1) biosynthetic enzyme and higher transcript and protein levels of Proline dehydrogenase 1 (ProDH1), a key-enzyme in proline catabolism.	Proline	10-17	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	116-121
25628629-8	2014	The lower proline accumulation is correlated with a lower transcript level of Pyrroline-5-carboxylate synthetase 1 (P5CS1) biosynthetic enzyme and higher transcript and protein levels of Proline dehydrogenase 1 (ProDH1), a key-enzyme in proline catabolism.	Proline	10-17	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	187-210
25588053-6	2015	Our data suggest that proline-directed phosphorylation regulates Rta by licensing binding to Pin1.	Proline	22-29	MAS related GPR family member F	Homo sapiens	65-68
25628629-8	2014	The lower proline accumulation is correlated with a lower transcript level of Pyrroline-5-carboxylate synthetase 1 (P5CS1) biosynthetic enzyme and higher transcript and protein levels of Proline dehydrogenase 1 (ProDH1), a key-enzyme in proline catabolism.	Proline	10-17	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	212-218
25588053-6	2015	Our data suggest that proline-directed phosphorylation regulates Rta by licensing binding to Pin1.	Proline	22-29	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	93-97
25628629-8	2014	The lower proline accumulation is correlated with a lower transcript level of Pyrroline-5-carboxylate synthetase 1 (P5CS1) biosynthetic enzyme and higher transcript and protein levels of Proline dehydrogenase 1 (ProDH1), a key-enzyme in proline catabolism.	Proline	237-244	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	212-218
25628629-9	2014	We also found that the ProDH1 expression is induced in a pi3k-hemizygous mutant, further demonstrating that PI3K is involved in the regulation of proline catabolism through transcriptional regulation of ProDH1.	Proline	146-153	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	23-29
25564858-1	2015	Prolyl oligopeptidase (POP) is a large 80 kDa protease, which cleaves oligopeptides at the C-terminal side of proline residues and constitutes an important pharmaceutical target.	Proline	110-117	prolyl endopeptidase	Homo sapiens	0-21
25569235-9	2015	GWAS replicated three known loci in the metabolome wide significance: CPS1 with glycine (P-value  = 1.27x10-32), PRODH with proline (P-value  = 1.11x10-19), SLC16A9 with carnitine level (P-value  = 4.81x10-14) and uncovered a novel association between DMGDH and dimethyl-glycine (P-value  = 1.65x10-19) level.	Proline	124-131	proline dehydrogenase 1	Homo sapiens	113-118
25569235-9	2015	GWAS replicated three known loci in the metabolome wide significance: CPS1 with glycine (P-value  = 1.27x10-32), PRODH with proline (P-value  = 1.11x10-19), SLC16A9 with carnitine level (P-value  = 4.81x10-14) and uncovered a novel association between DMGDH and dimethyl-glycine (P-value  = 1.65x10-19) level.	Proline	124-131	solute carrier family 16 member 9	Homo sapiens	157-164
25569235-9	2015	GWAS replicated three known loci in the metabolome wide significance: CPS1 with glycine (P-value  = 1.27x10-32), PRODH with proline (P-value  = 1.11x10-19), SLC16A9 with carnitine level (P-value  = 4.81x10-14) and uncovered a novel association between DMGDH and dimethyl-glycine (P-value  = 1.65x10-19) level.	Proline	124-131	dimethylglycine dehydrogenase	Homo sapiens	252-257
25564858-1	2015	Prolyl oligopeptidase (POP) is a large 80 kDa protease, which cleaves oligopeptides at the C-terminal side of proline residues and constitutes an important pharmaceutical target.	Proline	110-117	prolyl endopeptidase	Homo sapiens	23-26
25562660-5	2015	Unlike other EVH1 domains that interact with proline-rich ligands, the crystal structure of the Flfl amino-terminal EVH1 domain bound to a CENP-C peptide reveals a new target-recognition mode for the phosphatase subunit.	Proline	45-52	falafel	Drosophila melanogaster	96-100
25562660-5	2015	Unlike other EVH1 domains that interact with proline-rich ligands, the crystal structure of the Flfl amino-terminal EVH1 domain bound to a CENP-C peptide reveals a new target-recognition mode for the phosphatase subunit.	Proline	45-52	Centromeric protein-C	Drosophila melanogaster	139-145
25744464-7	2015	Comparison of the structures of IMP-1 and IMP-2, which have an 85% amino acid identity, suggests that the amino acid substitution at position 68 on a beta-strand (beta3) (Pro in IMP-1 versus Ser in IMP-2) may be a staple factor affecting the flexibility of loop 1 (comprising residues at positions 60-66; EVNGWGV).	Proline	171-174	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	32-37
26745067-4	2015	In HeLa S3 cells treated with siRNA for HPV E6, adenovirus-mediated transduction was enhanced by an upstream ERE linked to a p53 gene carrying a proline variant at codon 72, but not for a p53 gene with arginine variant at codon 72.	Proline	145-152	tumor protein p53	Homo sapiens	125-128
25247810-3	2015	We also demonstrate that a proline residue in the meander region at position 427 in human CYP4B1 and 422 in rabbit CYP4B1 is important for protein stability and rescues the 4-IPO bioactivation of the human enzyme, but is not essential for the catalytic activity of the rabbit CYP4B1 protein.	Proline	27-34	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	90-96
25247810-3	2015	We also demonstrate that a proline residue in the meander region at position 427 in human CYP4B1 and 422 in rabbit CYP4B1 is important for protein stability and rescues the 4-IPO bioactivation of the human enzyme, but is not essential for the catalytic activity of the rabbit CYP4B1 protein.	Proline	27-34	cytochrome P450 4B1	Oryctolagus cuniculus	115-121
25247810-3	2015	We also demonstrate that a proline residue in the meander region at position 427 in human CYP4B1 and 422 in rabbit CYP4B1 is important for protein stability and rescues the 4-IPO bioactivation of the human enzyme, but is not essential for the catalytic activity of the rabbit CYP4B1 protein.	Proline	27-34	cytochrome P450 4B1	Oryctolagus cuniculus	115-121
25744464-10	2015	Loop 1 of IMP-2 has a more flexible structure in comparison to IMP-1 due to having a Ser residue instead of the Pro residue at position 68, indicating that this difference in sequence may be a trigger to induce a more flexible conformation in loop 1.	Proline	112-115	insulin like growth factor 2 mRNA binding protein 2	Homo sapiens	10-15
26491469-3	2015	We employed this method to study molecular recognition of a Src homology 3 (SH3) domain from the yeast protein Sho1 for a peptide containing the proline-rich recognition sequence of its physiological binding partner Pbs2.	Proline	145-152	osmosensor SHO1	Saccharomyces cerevisiae S288C	111-115
26491469-3	2015	We employed this method to study molecular recognition of a Src homology 3 (SH3) domain from the yeast protein Sho1 for a peptide containing the proline-rich recognition sequence of its physiological binding partner Pbs2.	Proline	145-152	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	216-220
26745067-5	2015	Expression levels of p53 mRNA and Coxsackie/adenovirus receptor (CAR) mRNA after adenovirus-mediated transfer of an ERE-linked p53 gene (proline variant at codon 72) were higher compared with those after non-ERE-linked p53 gene transfer in siRNA-treated HeLa S3 cells.	Proline	137-144	tumor protein p53	Homo sapiens	21-24
26745067-5	2015	Expression levels of p53 mRNA and Coxsackie/adenovirus receptor (CAR) mRNA after adenovirus-mediated transfer of an ERE-linked p53 gene (proline variant at codon 72) were higher compared with those after non-ERE-linked p53 gene transfer in siRNA-treated HeLa S3 cells.	Proline	137-144	CXADR Ig-like cell adhesion molecule	Homo sapiens	34-63
26745067-5	2015	Expression levels of p53 mRNA and Coxsackie/adenovirus receptor (CAR) mRNA after adenovirus-mediated transfer of an ERE-linked p53 gene (proline variant at codon 72) were higher compared with those after non-ERE-linked p53 gene transfer in siRNA-treated HeLa S3 cells.	Proline	137-144	CXADR Ig-like cell adhesion molecule	Homo sapiens	65-68
26745067-5	2015	Expression levels of p53 mRNA and Coxsackie/adenovirus receptor (CAR) mRNA after adenovirus-mediated transfer of an ERE-linked p53 gene (proline variant at codon 72) were higher compared with those after non-ERE-linked p53 gene transfer in siRNA-treated HeLa S3 cells.	Proline	137-144	tumor protein p53	Homo sapiens	127-130
26745067-5	2015	Expression levels of p53 mRNA and Coxsackie/adenovirus receptor (CAR) mRNA after adenovirus-mediated transfer of an ERE-linked p53 gene (proline variant at codon 72) were higher compared with those after non-ERE-linked p53 gene transfer in siRNA-treated HeLa S3 cells.	Proline	137-144	tumor protein p53	Homo sapiens	127-130
26745067-6	2015	Western blot analysis showed lower beta-tubulin levels and comparatively higher p53/beta-tubulin or CAR /beta-tubulin ratios in siRNA-treated HeLa S3 cells after adenovirus-mediated ERE-linked p53 gene (proline variant at codon 72) transfer compared with those in non-siRNA-treated cells.	Proline	203-210	tumor protein p53	Homo sapiens	193-196
26745067-7	2015	Apoptosis, as measured by annexin V binding, was higher after adenovirus-mediated ERE-linked p53 gene (proline variant at codon 72) transfer compared with that after non-ERE-linked p53 gene transfer in siRNA-treated cells.	Proline	103-110	tumor protein p53	Homo sapiens	93-96
25744464-7	2015	Comparison of the structures of IMP-1 and IMP-2, which have an 85% amino acid identity, suggests that the amino acid substitution at position 68 on a beta-strand (beta3) (Pro in IMP-1 versus Ser in IMP-2) may be a staple factor affecting the flexibility of loop 1 (comprising residues at positions 60-66; EVNGWGV).	Proline	171-174	insulin like growth factor 2 mRNA binding protein 2	Homo sapiens	42-47
26133706-3	2015	PIN1 specifically binds phosphorylated serine or threonine residues immediately preceding proline (pSer/Thr-Pro) and then regulates protein functions, including catalytic activity, phosphorylation status, protein interactions, subcellular location, and protein stability, by promoting cis/trans isomerization of the peptide bond.	Proline	90-97	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
25744464-7	2015	Comparison of the structures of IMP-1 and IMP-2, which have an 85% amino acid identity, suggests that the amino acid substitution at position 68 on a beta-strand (beta3) (Pro in IMP-1 versus Ser in IMP-2) may be a staple factor affecting the flexibility of loop 1 (comprising residues at positions 60-66; EVNGWGV).	Proline	171-174	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	163-168
26133706-3	2015	PIN1 specifically binds phosphorylated serine or threonine residues immediately preceding proline (pSer/Thr-Pro) and then regulates protein functions, including catalytic activity, phosphorylation status, protein interactions, subcellular location, and protein stability, by promoting cis/trans isomerization of the peptide bond.	Proline	108-111	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
25744464-7	2015	Comparison of the structures of IMP-1 and IMP-2, which have an 85% amino acid identity, suggests that the amino acid substitution at position 68 on a beta-strand (beta3) (Pro in IMP-1 versus Ser in IMP-2) may be a staple factor affecting the flexibility of loop 1 (comprising residues at positions 60-66; EVNGWGV).	Proline	171-174	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	178-183
26553010-1	2015	Proline dehydrogenase/proline oxidase (PRODH/POX) is an enzyme catalyzing the first step of proline degradation, during which ROS and/or ATP is generated.	Proline	22-29	proline dehydrogenase 1	Homo sapiens	39-48
25266154-5	2015	Disruption of the AVT7 gene enhanced both vacuolar contents of several amino acids and uptake activities of glutamine and proline by vacuolar membrane vesicles.	Proline	122-129	Avt7p	Saccharomyces cerevisiae S288C	18-22
25469238-5	2015	A C-terminal proline-rich segment in WDCP was shown to mediate binding to the Src homology 3 domain of the Src family kinase hematopoietic cell kinase (Hck).	Proline	13-20	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	125-150
25469238-5	2015	A C-terminal proline-rich segment in WDCP was shown to mediate binding to the Src homology 3 domain of the Src family kinase hematopoietic cell kinase (Hck).	Proline	13-20	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	152-155
25590690-2	2015	We previously cloned the dog p21 gene and found that unlike human p21, dog p21 is expressed as 2 isoforms due to the proline-directed phosphorylation at serine 123 (S123).	Proline	117-124	cyclin dependent kinase inhibitor 1A	Homo sapiens	29-32
25986565-10	2015	The proline-rich loop overhanging the FKBP52 FK1 catalytic domain is functionally important and likely represents an interaction surface within the receptor-chaperone complex.	Proline	4-11	FK506 binding protein 4	Mus musculus	38-44
25474014-10	2015	Of special interest, modulatory proteins such as parkinson protein 7 and oral cancer overexpressed 1 interact with pyrroline-5-carboxylate reductase, a critical component of the proline regulatory axis.	Proline	178-185	LTO1 maturation factor of ABCE1	Homo sapiens	73-100
25986565-11	2015	Thus, the targeting of FKBP52 proline-rich loop interactions is the most attractive therapeutic approach to disrupt FKBP52 regulation of receptor activity in steroid hormone receptor-dependent physiology and disease.	Proline	30-37	FK506 binding protein 4	Mus musculus	23-29
25723507-3	2015	Dipeptidyl peptidase 4 (DPP4) cleaves N-terminal dipeptides from polypeptides when the second residue is proline, hydroxyproline, dehydroproline or alanine.	Proline	105-112	dipeptidyl peptidase 4	Homo sapiens	0-22
25723507-3	2015	Dipeptidyl peptidase 4 (DPP4) cleaves N-terminal dipeptides from polypeptides when the second residue is proline, hydroxyproline, dehydroproline or alanine.	Proline	105-112	dipeptidyl peptidase 4	Homo sapiens	24-28
25986565-11	2015	Thus, the targeting of FKBP52 proline-rich loop interactions is the most attractive therapeutic approach to disrupt FKBP52 regulation of receptor activity in steroid hormone receptor-dependent physiology and disease.	Proline	30-37	FK506 binding protein 4	Mus musculus	116-122
25128817-1	2015	Cyclin dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, requires p39 for its enzymatic activity, and is implicated in cytoskeletal organization and contraction in numerous cell types.	Proline	36-43	cyclin dependent kinase 5	Homo sapiens	0-25
25128817-1	2015	Cyclin dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, requires p39 for its enzymatic activity, and is implicated in cytoskeletal organization and contraction in numerous cell types.	Proline	36-43	cyclin dependent kinase 5	Homo sapiens	27-31
25128817-1	2015	Cyclin dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, requires p39 for its enzymatic activity, and is implicated in cytoskeletal organization and contraction in numerous cell types.	Proline	36-43	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	87-90
25605490-3	2015	Recently, the association between the p53 gene encoding for proline at codon 72 and primary open-angle glaucoma (POAG) has been studied in some ethnic groups.	Proline	60-67	tumor protein p53	Homo sapiens	38-41
25572184-0	2015	Hb Feilding [beta12(A9)Thr   Pro; HBB: c.37A&gt;C]: a novel unstable beta-globin chain variant.	Proline	29-32	hemoglobin subunit beta	Homo sapiens	34-37
25976777-5	2015	Hb Dartmouth is a variant caused by a missense mutation at codon 66 of the alpha2-globin gene (HBA2: c.200T&gt;C), resulting in the substitution of leucine by proline.	Proline	159-166	hemoglobin subunit alpha 2	Homo sapiens	75-88
25976777-5	2015	Hb Dartmouth is a variant caused by a missense mutation at codon 66 of the alpha2-globin gene (HBA2: c.200T&gt;C), resulting in the substitution of leucine by proline.	Proline	159-166	hemoglobin subunit alpha 2	Homo sapiens	95-99
25187058-10	2015	Three TAX1BP1-specific pairwise interactions locate in the loop regions, each augmented by a proline-aromatic interaction.	Proline	93-100	Tax1 binding protein 1	Homo sapiens	6-13
25187058-11	2015	The three proline-aromatic clusters are linked together by more generic hydrophobic interactions, forming a unique hydrophobic surface at one end of the TAX1BP1 SKICH domain.	Proline	10-17	Tax1 binding protein 1	Homo sapiens	153-160
25528892-8	2015	In addition, three potential pathways and their related DEGs: spermidine/spermine N1-acetyltransferase 1, amiloride-binding protein 1 and adenosylmethionine decarboxylase 1 were associated with arginine and proline metabolism.	Proline	207-214	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	62-104
24738488-3	2015	ALS6 is caused by the genetic mutation in the proline/tyrosine-nuclear localization signals of the Fused in sarcoma Protein (FUS).	Proline	46-53	FUS RNA binding protein	Homo sapiens	125-128
25349247-6	2015	Luminal leptin (25 nM) inhibited the absorption of 2 mM Pro, 5 mM beta-Ala, and 5 mM Gln by approximately 45% after 5-15 min; the effect remained constant until the end of the experiment (80 min) and was rapidly and completely reversed when leptin was removed from the perfusion medium.	Proline	56-59	leptin	Rattus norvegicus	8-14
25528892-8	2015	In addition, three potential pathways and their related DEGs: spermidine/spermine N1-acetyltransferase 1, amiloride-binding protein 1 and adenosylmethionine decarboxylase 1 were associated with arginine and proline metabolism.	Proline	207-214	amine oxidase copper containing 1	Homo sapiens	106-133
25447263-2	2015	We have crystallized the complex between the SH3 domain of the c-Src tyrosine kinase and the C-terminal proline rich motif of the NS5A protein (A349PPIPPPRRKR359).	Proline	104-111	C-terminal Src kinase	Homo sapiens	63-84
25447263-6	2015	Our results show the interaction of the SH3 domain of the c-Src tyrosine kinase with a proline rich motif in the NS5A protein and point to their potential interaction in vivo.	Proline	87-94	C-terminal Src kinase	Homo sapiens	58-79
25524207-6	2015	Moreover, proline mutations in the upper hinge region and removal of the Fc glycan enhanced the FVIII-mimetic activity, suggesting that flexibility of the upper hinge region and the Fc portion structure are important for the FVIII-mimetic activity.	Proline	10-17	coagulation factor VIII	Homo sapiens	96-101
25502079-3	2015	A common polymorphism of the p53 codon 72 in exon 4 with two alleles encoding arginine or proline is known at this locus.	Proline	90-97	tumor protein p53	Homo sapiens	29-32
25524207-6	2015	Moreover, proline mutations in the upper hinge region and removal of the Fc glycan enhanced the FVIII-mimetic activity, suggesting that flexibility of the upper hinge region and the Fc portion structure are important for the FVIII-mimetic activity.	Proline	10-17	coagulation factor VIII	Homo sapiens	225-230
25253241-5	2014	The pleckstrin homology (PH) and catalytic domains (CD) of Akt interacted with the proline-rich domain (PRD) of Dab2 based on yeast-two hybrid (Y2H) experiments.	Proline	83-90	AKT serine/threonine kinase 1	Homo sapiens	59-62
25736758-4	2015	The NF-kappaB essential modulator (NEMO, also known IKKgamma), which plays a key role in the NF-kappaB signaling pathway, belongs to the latter family of proteins since it contains two distal NOA (also known UBAN/CC2-LZ/NUB) and ZF UBDs, separated by an unstructured proline-rich linker of about 40 residues in length.	Proline	267-274	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	4-33
25736758-4	2015	The NF-kappaB essential modulator (NEMO, also known IKKgamma), which plays a key role in the NF-kappaB signaling pathway, belongs to the latter family of proteins since it contains two distal NOA (also known UBAN/CC2-LZ/NUB) and ZF UBDs, separated by an unstructured proline-rich linker of about 40 residues in length.	Proline	267-274	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	35-39
25736758-4	2015	The NF-kappaB essential modulator (NEMO, also known IKKgamma), which plays a key role in the NF-kappaB signaling pathway, belongs to the latter family of proteins since it contains two distal NOA (also known UBAN/CC2-LZ/NUB) and ZF UBDs, separated by an unstructured proline-rich linker of about 40 residues in length.	Proline	267-274	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	52-60
25326457-0	2015	Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU domain-containing octamer-binding protein (Nono) during neuronal differentiation.	Proline	137-144	mitogen-activated protein kinase 8	Rattus norvegicus	55-78
25326457-0	2015	Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU domain-containing octamer-binding protein (Nono) during neuronal differentiation.	Proline	137-144	mitogen-activated protein kinase 8	Rattus norvegicus	80-83
26340066-3	2015	Regulation of proline accumulation in this system seems complex and JA-deficient (jar1-1) and JA-insensitive (jai1) lines accumulating high levels of proline despite their very low ABA levels seems to discard an ABA-dependent response.	Proline	150-157	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	110-114
26340066-4	2015	However, the pattern of proline accumulation in jai1 seedlings parallels that of ABA.	Proline	24-31	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	48-52
26038983-5	2015	To reveal strain-specific sequence requirement, mutations that interfered with the propagation of W8 were identified by consecutive substitution of residues 5-55 of Sup35 by proline and insertion of glycine at alternate sites in this segment.	Proline	174-181	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	165-170
25504538-7	2015	Comparative sequencing of the mutants and wild type BnaA.AHAS.a coding sequences identified a C-to-T transition at either position 535 or 536 from the translation start site, which resulted in a substitution of proline with serine or leucine at position 197 according to the Arabidopsis thaliana protein sequence.	Proline	211-218	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	57-61
25196634-2	2014	Here we assessed the role played by the proline-directed serine/threonine kinase cyclin-dependent kinase 5 (Cdk5) in the nucleus accumbens (NAcc) on the expression of the conditioned locomotion normally observed when rats are returned to a context previously paired with amphetamine.	Proline	40-47	cyclin-dependent kinase 5	Rattus norvegicus	81-106
25196634-2	2014	Here we assessed the role played by the proline-directed serine/threonine kinase cyclin-dependent kinase 5 (Cdk5) in the nucleus accumbens (NAcc) on the expression of the conditioned locomotion normally observed when rats are returned to a context previously paired with amphetamine.	Proline	40-47	cyclin-dependent kinase 5	Rattus norvegicus	108-112
25807947-2	2015	One important kinase at the synapse is the proline-directed serine/ threonine kinase Cdk5.	Proline	43-50	cyclin dependent kinase 5	Homo sapiens	85-89
26340231-3	2015	The freezing tolerance phenotype showed in the sag101, eds1 and pad4 mutants was correlated with the transcriptional upregulation of C-REPEAT/DRE BINDING FACTORs (CBFs) and their regulons as well as increased levels of proline.	Proline	219-226	senescence-associated gene 101	Arabidopsis thaliana	47-53
26340231-3	2015	The freezing tolerance phenotype showed in the sag101, eds1 and pad4 mutants was correlated with the transcriptional upregulation of C-REPEAT/DRE BINDING FACTORs (CBFs) and their regulons as well as increased levels of proline.	Proline	219-226	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	55-59
26340231-3	2015	The freezing tolerance phenotype showed in the sag101, eds1 and pad4 mutants was correlated with the transcriptional upregulation of C-REPEAT/DRE BINDING FACTORs (CBFs) and their regulons as well as increased levels of proline.	Proline	219-226	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	64-68
25521377-0	2014	Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.	Proline	10-17	RAN, member RAS oncogene family	Homo sapiens	27-30
25521377-0	2014	Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.	Proline	10-17	C9orf72-SMCR8 complex subunit	Homo sapiens	52-59
25253241-5	2014	The pleckstrin homology (PH) and catalytic domains (CD) of Akt interacted with the proline-rich domain (PRD) of Dab2 based on yeast-two hybrid (Y2H) experiments.	Proline	83-90	DAB adaptor protein 2	Homo sapiens	112-116
25685357-8	2014	The other peptide (Valine-Histidine-Proline-Lysine-Glutamine-Histidine-Arginine or VHPKQHR) was identified via phage display and targets vascular endothelial cells through the vascular cell adhesion molecule-1 (VCAM-1).	Proline	36-43	vascular cell adhesion molecule 1	Homo sapiens	176-209
25370813-8	2014	Signalling pathways responsible for cell growth and apoptosis have also been found altered after eIF3D silencing, such as AMPKalpha (AMP-activated protein kinase alpha), Bad, PRAS40 [proline-rich Akt (PKB) substrate of 40 kDa], SAPK (stress-activated protein kinase)/JNK (c-Jun N-terminal kinase), GSK3beta and PARP [poly(ADP-ribose) polymerase].	Proline	183-190	eukaryotic translation initiation factor 3 subunit D	Homo sapiens	97-102
25685357-8	2014	The other peptide (Valine-Histidine-Proline-Lysine-Glutamine-Histidine-Arginine or VHPKQHR) was identified via phage display and targets vascular endothelial cells through the vascular cell adhesion molecule-1 (VCAM-1).	Proline	36-43	vascular cell adhesion molecule 1	Homo sapiens	211-217
25343306-0	2014	The proline-rich region of 18.5 kDa myelin basic protein binds to the SH3-domain of Fyn tyrosine kinase with the aid of an upstream segment to form a dynamic complex in vitro.	Proline	4-11	myelin basic protein	Mus musculus	36-56
25383939-3	2014	These dimers appear to be formed by cyclic electrostatic interactions between CO2(-) and NH2(+) groups on neighboring proline molecules, which causes the ring motifs of proline to be roughly parallel to one another.	Proline	118-125	complement C2	Homo sapiens	78-81
25383939-3	2014	These dimers appear to be formed by cyclic electrostatic interactions between CO2(-) and NH2(+) groups on neighboring proline molecules, which causes the ring motifs of proline to be roughly parallel to one another.	Proline	169-176	complement C2	Homo sapiens	78-81
25490095-8	2014	Changes in this hydrogen-bond network lead to the displacement of the c-Src-SH3 distal loop, resulting also in conformational changes of Leu100 that might be related to the binding of proline rich motifs.	Proline	184-191	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	70-75
25343306-0	2014	The proline-rich region of 18.5 kDa myelin basic protein binds to the SH3-domain of Fyn tyrosine kinase with the aid of an upstream segment to form a dynamic complex in vitro.	Proline	4-11	Fyn proto-oncogene	Mus musculus	84-87
25343306-2	2014	It does so primarily via a central proline-rich SH3 (Src homology 3) ligand (T92-R104, murine 18.5 kDa MBP sequence numbering) that is part of a molecular switch due to its high degree of conservation and modification by MAP (mitogen-activated protein) and other kinases, especially at residues T92 and T95.	Proline	35-42	myelin basic protein	Mus musculus	103-106
25584020-2	2014	Functional and binding studies suggest that the proline-rich region at the carboxy terminus of GILZ binds the p65 subunit of NFkappaB and suppresses the immunoinflammatory response.	Proline	48-55	TSC22 domain family member 3	Homo sapiens	95-99
25287063-7	2014	TYMP contains an N-terminal SH3 domain-binding proline-rich motif and forms a complex with the tyrosine kinases Lyn, Fyn, and Yes in platelets.	Proline	47-54	thymidine phosphorylase	Mus musculus	0-4
25287063-7	2014	TYMP contains an N-terminal SH3 domain-binding proline-rich motif and forms a complex with the tyrosine kinases Lyn, Fyn, and Yes in platelets.	Proline	47-54	LYN proto-oncogene, Src family tyrosine kinase	Mus musculus	112-115
25287063-7	2014	TYMP contains an N-terminal SH3 domain-binding proline-rich motif and forms a complex with the tyrosine kinases Lyn, Fyn, and Yes in platelets.	Proline	47-54	Fyn proto-oncogene	Mus musculus	117-120
25584020-2	2014	Functional and binding studies suggest that the proline-rich region at the carboxy terminus of GILZ binds the p65 subunit of NFkappaB and suppresses the immunoinflammatory response.	Proline	48-55	RELA proto-oncogene, NF-kB subunit	Homo sapiens	110-113
25584020-2	2014	Functional and binding studies suggest that the proline-rich region at the carboxy terminus of GILZ binds the p65 subunit of NFkappaB and suppresses the immunoinflammatory response.	Proline	48-55	nuclear factor kappa B subunit 1	Homo sapiens	125-133
25584020-4	2014	Previously, we observed that a synthetic peptide (GILZ-P) derived from the proline-rich region of GILZ bound activated p65 and ameliorated experimental encephalomyelitis.	Proline	75-82	TSC22 domain family member 3	Homo sapiens	50-54
25468995-6	2014	A similar phenotype was observed in mice with a mutation in the cytoplasmic proline-rich sequence (PRS) of CD3epsilon, the binding site for Nck.	Proline	76-83	CD3 antigen, epsilon polypeptide	Mus musculus	107-117
25584020-4	2014	Previously, we observed that a synthetic peptide (GILZ-P) derived from the proline-rich region of GILZ bound activated p65 and ameliorated experimental encephalomyelitis.	Proline	75-82	TSC22 domain family member 3	Homo sapiens	98-102
25468995-6	2014	A similar phenotype was observed in mice with a mutation in the cytoplasmic proline-rich sequence (PRS) of CD3epsilon, the binding site for Nck.	Proline	76-83	non-catalytic region of tyrosine kinase adaptor protein 1	Mus musculus	140-143
25584020-4	2014	Previously, we observed that a synthetic peptide (GILZ-P) derived from the proline-rich region of GILZ bound activated p65 and ameliorated experimental encephalomyelitis.	Proline	75-82	RELA proto-oncogene, NF-kB subunit	Homo sapiens	119-122
25193156-4	2014	SCPPPQ1 is a highly conserved, 75-residue, secreted protein rich in proline, leucine, glutamine and phenylalanine.	Proline	68-75	secretory calcium-binding phosphoprotein proline-glutamine rich 1-like	Rattus norvegicus	0-7
25478830-5	2014	This analysis revealed the specific loss of a crucial active-site residue in higher eukaryotic Cwc27 proteins, suggesting that the protein evolved from a prolyl isomerase to a pure proline binder.	Proline	181-188	CWC27 spliceosome associated cyclophilin	Homo sapiens	95-100
25473227-7	2014	Mutational analysis of the patient"s DNA revealed a thymine-to-cytosine transition at codon 608 in the KRT-5 gene, resulting in a leucine-to-proline substitution in the keratin 5 protein.	Proline	141-148	keratin 5	Homo sapiens	103-108
25473227-7	2014	Mutational analysis of the patient"s DNA revealed a thymine-to-cytosine transition at codon 608 in the KRT-5 gene, resulting in a leucine-to-proline substitution in the keratin 5 protein.	Proline	141-148	keratin 5	Homo sapiens	169-178
25173462-6	2014	Furthermore, the c-Jun-N-terminal kinase/Ste20-related protein proline/alanine-rich kinase (JNK/SPAK) pathway played a key role in the influence of NAG-1 on cell viability, whereas the addition of the JNK pathway inhibitor SP600125 resulted in an inhibitory effect on NAG-1 and recovery of Taiwanin-A-treated cells.	Proline	63-70	mitogen-activated protein kinase 8	Homo sapiens	92-95
25216328-2	2014	Both membrane-associated and soluble DPP4 exert catalytic activity, cleaving proteins containing a position 2 alanine or proline.	Proline	121-128	dipeptidyl peptidase 4	Homo sapiens	37-41
25173462-6	2014	Furthermore, the c-Jun-N-terminal kinase/Ste20-related protein proline/alanine-rich kinase (JNK/SPAK) pathway played a key role in the influence of NAG-1 on cell viability, whereas the addition of the JNK pathway inhibitor SP600125 resulted in an inhibitory effect on NAG-1 and recovery of Taiwanin-A-treated cells.	Proline	63-70	serine/threonine kinase 39	Homo sapiens	96-100
25173462-6	2014	Furthermore, the c-Jun-N-terminal kinase/Ste20-related protein proline/alanine-rich kinase (JNK/SPAK) pathway played a key role in the influence of NAG-1 on cell viability, whereas the addition of the JNK pathway inhibitor SP600125 resulted in an inhibitory effect on NAG-1 and recovery of Taiwanin-A-treated cells.	Proline	63-70	growth differentiation factor 15	Homo sapiens	148-153
25244701-4	2014	Using the intrinsically disordered N-terminal region of the p53 protein as an experimental model, a set of proline (PRO) and alanine (ALA) to glycine (GLY) substitution variants were designed to modulate backbone conformational propensities without introducing non-native intramolecular interactions.	Proline	107-114	tumor protein p53	Homo sapiens	60-63
24115240-1	2014	BACKGROUND: The TP53 single nucleotide polymorphism (SNP) rs1042522 encodes arginine (Arg) or proline (Pro).	Proline	94-101	tumor protein p53	Homo sapiens	16-20
24115240-1	2014	BACKGROUND: The TP53 single nucleotide polymorphism (SNP) rs1042522 encodes arginine (Arg) or proline (Pro).	Proline	103-106	tumor protein p53	Homo sapiens	16-20
25270619-2	2014	However, the hydroxylation of proline at 564 and asparagine at 803 in the HIF1alpha coding sequence facilitated the degradation of HIF1alpha and inhibited the transcription activity of the HIF1alpha promoter under normoxic conditions and confined the pro-angiogenic efficacy of HIF1alpha.	Proline	30-37	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	131-140
25270619-2	2014	However, the hydroxylation of proline at 564 and asparagine at 803 in the HIF1alpha coding sequence facilitated the degradation of HIF1alpha and inhibited the transcription activity of the HIF1alpha promoter under normoxic conditions and confined the pro-angiogenic efficacy of HIF1alpha.	Proline	30-37	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	131-140
25270619-2	2014	However, the hydroxylation of proline at 564 and asparagine at 803 in the HIF1alpha coding sequence facilitated the degradation of HIF1alpha and inhibited the transcription activity of the HIF1alpha promoter under normoxic conditions and confined the pro-angiogenic efficacy of HIF1alpha.	Proline	30-37	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	131-140
25187573-3	2014	Lubricin contains an serine/threonine/proline (STP)-rich domain composed of imperfect tandem repeats (EPAPTTPK), the target for O-glycosylation.	Proline	38-45	proteoglycan 4	Homo sapiens	0-8
25218132-8	2014	Chlorophyll and proline contents in Atdi19-3 mutant were higher, but in AtDi19-3 overexpression seedlings were lower than those in wild type.	Proline	16-23	drought-induced 19	Arabidopsis thaliana	36-42
25297623-4	2014	TTBK2 bound EB1 and Cep164 through its SxIP motifs and a proline-rich motif, respectively.	Proline	57-64	tau tubulin kinase 2	Homo sapiens	0-5
25297623-4	2014	TTBK2 bound EB1 and Cep164 through its SxIP motifs and a proline-rich motif, respectively.	Proline	57-64	microtubule associated protein RP/EB family member 1	Homo sapiens	12-15
25297623-4	2014	TTBK2 bound EB1 and Cep164 through its SxIP motifs and a proline-rich motif, respectively.	Proline	57-64	centrosomal protein 164	Homo sapiens	20-26
25297623-5	2014	Using TTBK2 variants that contained mutations in the SxIP or proline-rich motifs, we obtained evidence that Cep164, but not EB1, is essential for centriolar localization of TTBK2.	Proline	61-68	centrosomal protein 164	Homo sapiens	108-114
25391085-0	2014	Effects of terminal dimethylation and metal coordination of proline-2-formylpyridine thiosemicarbazone hybrids on lipophilicity, antiproliferative activity, and hR2 RNR inhibition.	Proline	60-67	ribonucleotide reductase regulatory subunit M2	Homo sapiens	161-164
25437863-4	2014	The yeast Protein Disulfide Isomerase family member Eps1p has Cys-X-X-Cys motifs and proline residues at the appropriate primary structural positions in its first two predicted thioredoxin-fold domains.	Proline	85-92	protein disulfide isomerase EPS1	Saccharomyces cerevisiae S288C	52-57
25244701-4	2014	Using the intrinsically disordered N-terminal region of the p53 protein as an experimental model, a set of proline (PRO) and alanine (ALA) to glycine (GLY) substitution variants were designed to modulate backbone conformational propensities without introducing non-native intramolecular interactions.	Proline	116-119	tumor protein p53	Homo sapiens	60-63
25429397-4	2014	The p53-bcl-2 mRNA interaction is modified by the substitution of proline by arginine within the p53 proline-rich domain (PRD).	Proline	66-73	transformation related protein 53, pseudogene	Mus musculus	4-7
25429397-4	2014	The p53-bcl-2 mRNA interaction is modified by the substitution of proline by arginine within the p53 proline-rich domain (PRD).	Proline	66-73	B cell leukemia/lymphoma 2	Mus musculus	8-13
25429397-4	2014	The p53-bcl-2 mRNA interaction is modified by the substitution of proline by arginine within the p53 proline-rich domain (PRD).	Proline	66-73	transformation related protein 53, pseudogene	Mus musculus	97-100
25429397-4	2014	The p53-bcl-2 mRNA interaction is modified by the substitution of proline by arginine within the p53 proline-rich domain (PRD).	Proline	101-108	transformation related protein 53, pseudogene	Mus musculus	4-7
25429397-4	2014	The p53-bcl-2 mRNA interaction is modified by the substitution of proline by arginine within the p53 proline-rich domain (PRD).	Proline	101-108	B cell leukemia/lymphoma 2	Mus musculus	8-13
25429397-4	2014	The p53-bcl-2 mRNA interaction is modified by the substitution of proline by arginine within the p53 proline-rich domain (PRD).	Proline	101-108	transformation related protein 53, pseudogene	Mus musculus	97-100
25429397-7	2014	On two genetic backgrounds, mice with targeted replacement of prolines in p53 PRD show enhanced expression of SPDEF and Bcl-2 and mucous cell metaplasia.	Proline	62-70	transformation related protein 53, pseudogene	Mus musculus	74-77
25429397-7	2014	On two genetic backgrounds, mice with targeted replacement of prolines in p53 PRD show enhanced expression of SPDEF and Bcl-2 and mucous cell metaplasia.	Proline	62-70	SAM pointed domain containing ets transcription factor	Mus musculus	110-115
25429397-7	2014	On two genetic backgrounds, mice with targeted replacement of prolines in p53 PRD show enhanced expression of SPDEF and Bcl-2 and mucous cell metaplasia.	Proline	62-70	B cell leukemia/lymphoma 2	Mus musculus	120-125
24706440-4	2014	By structure-function analysis of ROR1 mutants, we show that ROR1 encompasses two major substrate regions: one is located in the proline-rich domain and is directly phosphorylated by MET; the other resides in the pseudokinase domain and is phosphorylated through intermediate activation of SRC.	Proline	129-136	receptor tyrosine kinase like orphan receptor 1	Homo sapiens	34-38
25350771-6	2014	We found that the SH3 domain binds to the exon10 motif more strongly compared to the proline-rich domain (PRD) of dynamin 2.	Proline	85-92	dynamin 2	Homo sapiens	114-123
24706440-4	2014	By structure-function analysis of ROR1 mutants, we show that ROR1 encompasses two major substrate regions: one is located in the proline-rich domain and is directly phosphorylated by MET; the other resides in the pseudokinase domain and is phosphorylated through intermediate activation of SRC.	Proline	129-136	receptor tyrosine kinase like orphan receptor 1	Homo sapiens	61-65
24706440-4	2014	By structure-function analysis of ROR1 mutants, we show that ROR1 encompasses two major substrate regions: one is located in the proline-rich domain and is directly phosphorylated by MET; the other resides in the pseudokinase domain and is phosphorylated through intermediate activation of SRC.	Proline	129-136	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	290-293
24706440-5	2014	Differential phosphorylation of these two regions dictates the execution of specific responses: phosphorylation of the ROR1 proline-rich domain by MET-but not phosphorylation of the pseudokinase domain by SRC-is necessary and sufficient to control MET-driven proliferation and protection from apoptosis.	Proline	124-131	receptor tyrosine kinase like orphan receptor 1	Homo sapiens	119-123
25393623-7	2014	Plants overexpressing GhSnRK2 displayed evidence of reduced water loss, turgor regulation, elevated relative water content, biomass, and proline accumulation.	Proline	137-144	serine/threonine-protein kinase SRK2A-like	Gossypium hirsutum	22-29
24996823-9	2014	We also found that the galectin-3 N-terminal domain interacts with the proline-rich region of Alix.	Proline	71-78	galectin 3	Homo sapiens	23-33
25281266-1	2014	Bromodomain-PHD finger protein 1 (BRPF1) is part of the MOZ HAT complex and contains a unique combination of domains typically found in chromatin-associated factors, which include plant homeodomain (PHD) fingers, a bromodomain and a proline-tryptophan-tryptophan-proline (PWWP) domain.	Proline	233-240	bromodomain and PHD finger containing 1	Homo sapiens	0-32
25281266-1	2014	Bromodomain-PHD finger protein 1 (BRPF1) is part of the MOZ HAT complex and contains a unique combination of domains typically found in chromatin-associated factors, which include plant homeodomain (PHD) fingers, a bromodomain and a proline-tryptophan-tryptophan-proline (PWWP) domain.	Proline	233-240	bromodomain and PHD finger containing 1	Homo sapiens	34-39
25281266-1	2014	Bromodomain-PHD finger protein 1 (BRPF1) is part of the MOZ HAT complex and contains a unique combination of domains typically found in chromatin-associated factors, which include plant homeodomain (PHD) fingers, a bromodomain and a proline-tryptophan-tryptophan-proline (PWWP) domain.	Proline	263-270	bromodomain and PHD finger containing 1	Homo sapiens	0-32
25281266-1	2014	Bromodomain-PHD finger protein 1 (BRPF1) is part of the MOZ HAT complex and contains a unique combination of domains typically found in chromatin-associated factors, which include plant homeodomain (PHD) fingers, a bromodomain and a proline-tryptophan-tryptophan-proline (PWWP) domain.	Proline	263-270	bromodomain and PHD finger containing 1	Homo sapiens	34-39
25712892-1	2014	AIM: Arg72Pro is a polymorphism commonly occurring in the proline-rich domain of Tp53.	Proline	58-65	tumor protein p53	Homo sapiens	81-85
25253735-2	2014	There is growing evidence that putrescine produced from arginine (Arg) and proline via ornithine decarboxylase is a key regulator of angiogenesis, embryogenesis, as well as placental and fetal growth.	Proline	75-82	Ornithine decarboxylase 1	Drosophila melanogaster	87-110
25347266-4	2014	PE, Pro, and Arg all lowered blood levels of lactic acid and alanine aminotransferase (ALT).	Proline	4-7	glutamic pyruvic transaminase, soluble	Mus musculus	61-85
25347266-4	2014	PE, Pro, and Arg all lowered blood levels of lactic acid and alanine aminotransferase (ALT).	Proline	4-7	glutamic pyruvic transaminase, soluble	Mus musculus	87-90
25246528-11	2014	We also found that the interaction of profilin-actin complexes with the VASP-proline-rich domain and the binding of the VASP-F-actin binding domain to the side of growing filaments is critical for transforming actin polymerization into motion.	Proline	77-84	vasodilator stimulated phosphoprotein	Homo sapiens	72-76
25374254-4	2014	Previous studies have demonstrated a key role for cell cycle-dependent multi-site phosphorylation of Ngn2 protein at Serine-Proline (SP) sites for regulation of its neuronal differentiation activity, although the potential structural and functional consequences of phosphorylation at different regions of the protein are unclear.	Proline	124-131	neurogenin 2	Homo sapiens	101-105
25283153-1	2014	In this work, a modified version of the 44 amino acid human growth hormone-releasing hormone (hGHRH(1-44)) containing an N-terminal proline extension, a valine residue in position 14, and a C-terminus amidation (sequence: PYADAIFTNSYRKVVLGQLSARKLLQDIMSRQQGESNQERGARARL-NH2 ) has been identified in a confiscated product by liquid chromatography-high resolution mass spectrometry (LC-HRMS).	Proline	132-139	growth hormone releasing hormone	Homo sapiens	60-92
25283153-1	2014	In this work, a modified version of the 44 amino acid human growth hormone-releasing hormone (hGHRH(1-44)) containing an N-terminal proline extension, a valine residue in position 14, and a C-terminus amidation (sequence: PYADAIFTNSYRKVVLGQLSARKLLQDIMSRQQGESNQERGARARL-NH2 ) has been identified in a confiscated product by liquid chromatography-high resolution mass spectrometry (LC-HRMS).	Proline	132-139	growth hormone releasing hormone	Homo sapiens	94-99
24996823-9	2014	We also found that the galectin-3 N-terminal domain interacts with the proline-rich region of Alix.	Proline	71-78	programmed cell death 6 interacting protein	Homo sapiens	94-98
25313037-4	2014	XAF1 binds directly to the N-terminal proline-rich domain of p53 and thus interferes with E3 ubiquitin ligase MDM2 binding and ubiquitination of p53.	Proline	38-45	XIAP associated factor 1	Homo sapiens	0-4
25313037-4	2014	XAF1 binds directly to the N-terminal proline-rich domain of p53 and thus interferes with E3 ubiquitin ligase MDM2 binding and ubiquitination of p53.	Proline	38-45	tumor protein p53	Homo sapiens	61-64
25329151-5	2014	We find that Ulk2, which interacts with Kctd12 proteins via a small proline-serine rich domain, promotes branching and elaboration of dendrites.	Proline	68-75	unc-51 like autophagy activating kinase 2	Homo sapiens	13-17
25329151-5	2014	We find that Ulk2, which interacts with Kctd12 proteins via a small proline-serine rich domain, promotes branching and elaboration of dendrites.	Proline	68-75	potassium channel tetramerization domain containing 12	Homo sapiens	40-46
25329792-1	2014	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, which plays critical roles in a wide spectrum of neuronal functions including neuronal survival, neurite outgrowth, and synapse development and plasticity.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
25329792-1	2014	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, which plays critical roles in a wide spectrum of neuronal functions including neuronal survival, neurite outgrowth, and synapse development and plasticity.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
25142785-4	2014	In addition, increasing temperature changes the hydrophobicity of the ELP by exposure of hydrophobic valine-side chains to the solvent and hiding of proline residues.	Proline	149-156	nuclear receptor subfamily 5 group A member 1	Homo sapiens	70-73
25108128-9	2014	It was resulted that F0/1-HCV patients have significant differences of P53 at 72 (Pro/Pro and Arg/Arg) genotypes and dominant/recessive genetic models as well as APO-1 -670 A/A genotype and dominant genetic model as compared to F3/4-HCV patients.	Proline	82-85	tumor protein p53	Homo sapiens	71-74
25334008-7	2014	While the C-termini of VGLUT1 and 2 share a dileucine-like trafficking motif and a proline-, glutamate-, serine-, and threonine-rich PEST domain, only VGLUT1 contains two polyproline domains and a phosphorylation consensus sequence in a region of acidic amino acids.	Proline	83-90	solute carrier family 17 member 7	Homo sapiens	23-35
25334008-7	2014	While the C-termini of VGLUT1 and 2 share a dileucine-like trafficking motif and a proline-, glutamate-, serine-, and threonine-rich PEST domain, only VGLUT1 contains two polyproline domains and a phosphorylation consensus sequence in a region of acidic amino acids.	Proline	83-90	solute carrier family 17 member 7	Homo sapiens	23-29
25314575-2	2014	In this article, we reported that 3 of 69 (4.3%) diffuse large B-cell lymphomas (DLBCLs) exhibited a truncate NOTCH2 mutation at the nucleotide 7605 (G/A) in the cDNA sequence, which led to partial deletion of the C-terminal of PEST (proline-, glutamic acid-, serine- and threonine-rich) domain.	Proline	234-241	notch receptor 2	Homo sapiens	110-116
25297980-3	2014	Here, we demonstrate that endogenous NL2 undergoes proline-directed phosphorylation at its unique S714-P consensus site, leading to the recruitment of the peptidyl-prolyl cis-trans isomerase Pin1.	Proline	51-58	neuroligin 2	Mus musculus	37-40
25297980-3	2014	Here, we demonstrate that endogenous NL2 undergoes proline-directed phosphorylation at its unique S714-P consensus site, leading to the recruitment of the peptidyl-prolyl cis-trans isomerase Pin1.	Proline	51-58	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	191-195
24786704-10	2014	Increased expression of phospho-Ser261-AQP2 (proline-directed motif) was concomitant with the increase in urine output.	Proline	45-52	aquaporin 2	Rattus norvegicus	39-43
25284427-0	2014	SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation.	Proline	23-30	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	0-5
25284427-0	2014	SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation.	Proline	23-30	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
25284427-3	2014	Here we show that during starvation of Caenorhabditis elegans, proline catabolism is coupled with lipid metabolism by SKN-1.	Proline	63-70	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	118-123
25112878-3	2014	To address this we examined in Saccharomyces cerevisiae the effect of knocking out the PRO1, PRO2, and PRO3 genes responsible for proline biosynthesis.	Proline	130-137	glutamate 5-kinase	Saccharomyces cerevisiae S288C	87-91
25112878-3	2014	To address this we examined in Saccharomyces cerevisiae the effect of knocking out the PRO1, PRO2, and PRO3 genes responsible for proline biosynthesis.	Proline	130-137	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	103-107
25112878-4	2014	The null mutants pro1, pro2, and pro3 were shown to have increased sensitivity to ER stress relative to wild-type cells, which could be restored by proline or the corresponding genetic complementation.	Proline	148-155	glutamate 5-kinase	Saccharomyces cerevisiae S288C	17-21
25112878-4	2014	The null mutants pro1, pro2, and pro3 were shown to have increased sensitivity to ER stress relative to wild-type cells, which could be restored by proline or the corresponding genetic complementation.	Proline	148-155	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	33-37
25112878-6	2014	The pro3 mutant cells have higher intracellular reactive oxygen species, total glutathione, and a NADP(+)/NADPH ratio than wild-type cells under limiting proline conditions.	Proline	154-161	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	4-8
25112878-8	2014	To more broadly test the role of proline in ER stress, increased proline biosynthesis was shown to partially rescue the ER stress sensitivity of a hog1 null mutant in which the high osmolality pathway is disrupted.	Proline	65-72	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	147-151
24994675-1	2014	The human platelet alloantigen (HPA)-1 system, the first cause of alloimmune thrombocytopenia in Caucasians, results from leucine-to-proline substitution (alleles 1a and 1b) of residue 33 in beta3 subunit of the integrin alphaIIbbeta3.	Proline	133-140	heparanase	Homo sapiens	10-38
25299333-0	2014	Proline isomerization of the immune receptor-interacting protein RIN4 by a cyclophilin inhibits effector-triggered immunity in Arabidopsis.	Proline	0-7	RPM1 interacting protein 4	Arabidopsis thaliana	65-69
25299333-0	2014	Proline isomerization of the immune receptor-interacting protein RIN4 by a cyclophilin inhibits effector-triggered immunity in Arabidopsis.	Proline	0-7	Cyclophilin	Arabidopsis thaliana	75-86
25091199-0	2014	Sperm-specific glyceraldehyde-3-phosphate dehydrogenase is stabilized by additional proline residues and an interdomain salt bridge.	Proline	84-91	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	15-55
25091199-2	2014	A comparative analysis of the structures of these isoenzymes revealed characteristic features, which could be important for the stability of GAPDS: six specific proline residues and three buried salt bridges.	Proline	161-168	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	141-146
25138305-2	2014	Galectin-3 is a unique, chimeric protein consisting of three distinct structural motifs: (i) a short NH2 terminal domain containing a serine phosphorylation site; (ii) a repetitive proline-rich collagen-alpha-like sequence cleavable by matrix metalloproteases; and (iii) a globular COOH-terminal domain containing a carbohydrate-binding motif and an NWGR anti-death motif.	Proline	181-188	galectin 3	Homo sapiens	0-10
24948556-1	2014	As the first and rate-limiting enzyme of proline degradation, PROLINE DEHYDROGENASE1 (PDH1) is tightly regulated during plant stress responses, including induction under hypoosmolarity and repression under water deficit.	Proline	41-48	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	62-84
24948556-1	2014	As the first and rate-limiting enzyme of proline degradation, PROLINE DEHYDROGENASE1 (PDH1) is tightly regulated during plant stress responses, including induction under hypoosmolarity and repression under water deficit.	Proline	41-48	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	86-90
25271995-3	2014	The full-length tesk1 cDNA consists of 1,672 nucleotides, encoding a 331 amino acid polypeptide with a characteristic structure composed of an N-terminal kinase domain and a C-terminal proline-rich domain.	Proline	185-192	dual specificity testis-specific protein kinase 1	Cynoglossus semilaevis	16-21
25055140-1	2014	Numerous reports have shown that cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, critically contributes to the induction and maintenance of chronic pain induced by peripheral inflammation and nerve injury.	Proline	69-76	cyclin-dependent kinase 5	Rattus norvegicus	33-58
25055140-1	2014	Numerous reports have shown that cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, critically contributes to the induction and maintenance of chronic pain induced by peripheral inflammation and nerve injury.	Proline	69-76	cyclin-dependent kinase 5	Rattus norvegicus	60-64
25014022-2	2014	Abnormal expression of peripheral myelin protein 22 (PMP22) has been linked to CMT1A and is modeled by Trembler J (TrJ) mice, which carry the same leucine to proline substitution in PMP22 as affected pedigrees.	Proline	158-165	peripheral myelin protein 22	Mus musculus	23-51
25014022-2	2014	Abnormal expression of peripheral myelin protein 22 (PMP22) has been linked to CMT1A and is modeled by Trembler J (TrJ) mice, which carry the same leucine to proline substitution in PMP22 as affected pedigrees.	Proline	158-165	peripheral myelin protein 22	Mus musculus	53-58
25033027-4	2014	A functional polymorphism at codon 198 of the GPX1 gene causes a C/T substitution in exon 2, which encodes for either proline or leucine (Pro198Leu).	Proline	118-125	glutathione peroxidase 1	Homo sapiens	46-50
24724911-1	2014	BACKGROUND: The Diego blood group presents a major polymorphic site at Residue 854, causing a proline (Di(b) antigen) to leucine (Di(a) antigen) substitution.	Proline	94-101	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	16-33
25159840-1	2014	Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1) modulates phospho-signaling by catalyzing rotation of the bond between a phosphorylated serine or threonine before proline in proteins.	Proline	177-184	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-54
25308848-1	2014	Prolidase gene (PEPD) encodes prolidase enzyme, which is responsible for hydrolysis of dipeptides containing proline or hydroxyproline at their C-terminal end.	Proline	109-116	peptidase D	Mus musculus	0-9
25308848-1	2014	Prolidase gene (PEPD) encodes prolidase enzyme, which is responsible for hydrolysis of dipeptides containing proline or hydroxyproline at their C-terminal end.	Proline	109-116	peptidase D	Mus musculus	16-20
25308848-1	2014	Prolidase gene (PEPD) encodes prolidase enzyme, which is responsible for hydrolysis of dipeptides containing proline or hydroxyproline at their C-terminal end.	Proline	109-116	peptidase D	Mus musculus	30-39
25009140-8	2014	Pro 5 and Gly 6 adopt a type II tight turn and Lys 2"s zeta-NH3(+) is positioned to form a favorable cation-pi interaction with Trp 4"s indole ring.	Proline	0-3	aminoadipate-semialdehyde dehydrogenase	Homo sapiens	47-52
25009140-8	2014	Pro 5 and Gly 6 adopt a type II tight turn and Lys 2"s zeta-NH3(+) is positioned to form a favorable cation-pi interaction with Trp 4"s indole ring.	Proline	0-3	transient receptor potential cation channel subfamily C member 4	Homo sapiens	128-133
25279306-11	2014	The C allele encodes proline, which stabilizes the interaction of the TGFbeta1 signal peptide with SRP and translocon, resulting in elevation of TGFbeta1 secretion.	Proline	21-28	transforming growth factor beta 1	Homo sapiens	70-78
25279306-11	2014	The C allele encodes proline, which stabilizes the interaction of the TGFbeta1 signal peptide with SRP and translocon, resulting in elevation of TGFbeta1 secretion.	Proline	21-28	transforming growth factor beta 1	Homo sapiens	145-153
25187265-3	2014	Profilin1 (Pfn1) is a key actin-regulating protein that, besides actin, interacts with phosphoinositides and multiple proline-rich proteins, including the WAS protein (WASp)/WASp-interacting protein (WIP) complex.	Proline	118-125	profilin 1	Homo sapiens	0-9
25187265-3	2014	Profilin1 (Pfn1) is a key actin-regulating protein that, besides actin, interacts with phosphoinositides and multiple proline-rich proteins, including the WAS protein (WASp)/WASp-interacting protein (WIP) complex.	Proline	118-125	profilin 1	Homo sapiens	11-15
25100325-1	2014	Pin1 peptidyl-prolyl isomerase (PPIase) catalyzes specifically the pSer/pThr-Pro motif.	Proline	76-80	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
25100325-1	2014	Pin1 peptidyl-prolyl isomerase (PPIase) catalyzes specifically the pSer/pThr-Pro motif.	Proline	76-80	peptidylprolyl isomerase like 1	Homo sapiens	32-38
25034526-6	2014	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in lung cancer were 25.5, 37.7, and 36.8 %, respectively; frequencies in the controls were 53.4, 30.2, and 16.4 %, respectively (p &lt; 0.01).	Proline	60-63	tumor protein p53	Homo sapiens	19-22
25034526-6	2014	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in lung cancer were 25.5, 37.7, and 36.8 %, respectively; frequencies in the controls were 53.4, 30.2, and 16.4 %, respectively (p &lt; 0.01).	Proline	69-72	tumor protein p53	Homo sapiens	19-22
25034526-6	2014	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in lung cancer were 25.5, 37.7, and 36.8 %, respectively; frequencies in the controls were 53.4, 30.2, and 16.4 %, respectively (p &lt; 0.01).	Proline	69-72	tumor protein p53	Homo sapiens	19-22
25140605-6	2014	We describe a strategy for rationally designing analogues of hIAPP with improved properties; key proline mutations are combined with substitutions that increase the net charge of the molecule.	Proline	97-104	islet amyloid polypeptide	Homo sapiens	61-66
25086033-6	2014	Mammalian NKCCs are regulated by a kinase cascade consisting of the with-no-lysine (WNK) and Ste20-related proline/alanine-rich (SPAK)/oxidative stress response (OSR1) kinases.	Proline	107-114	serine/threonine kinase 24	Homo sapiens	93-98
25086033-6	2014	Mammalian NKCCs are regulated by a kinase cascade consisting of the with-no-lysine (WNK) and Ste20-related proline/alanine-rich (SPAK)/oxidative stress response (OSR1) kinases.	Proline	107-114	serine/threonine kinase 39	Homo sapiens	129-133
25086033-6	2014	Mammalian NKCCs are regulated by a kinase cascade consisting of the with-no-lysine (WNK) and Ste20-related proline/alanine-rich (SPAK)/oxidative stress response (OSR1) kinases.	Proline	107-114	odd-skipped related transcription factor 1	Homo sapiens	162-166
25197063-4	2014	We identify a proline-directed phosphorylation motif, at serines 861/864 upstream of these sites, which is a substrate for the peptidylprolyl cis/trans isomerase, Pin1, as well as the ERK1/2 kinases.	Proline	14-21	peptidylprolyl isomerase like 2	Homo sapiens	127-161
25197063-4	2014	We identify a proline-directed phosphorylation motif, at serines 861/864 upstream of these sites, which is a substrate for the peptidylprolyl cis/trans isomerase, Pin1, as well as the ERK1/2 kinases.	Proline	14-21	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	163-167
25197063-4	2014	We identify a proline-directed phosphorylation motif, at serines 861/864 upstream of these sites, which is a substrate for the peptidylprolyl cis/trans isomerase, Pin1, as well as the ERK1/2 kinases.	Proline	14-21	mitogen-activated protein kinase 3	Homo sapiens	184-190
25079693-2	2014	Here we report that prolyl hydroxylase 3 (PHD3) interacts with nonmuscle actin in human cells and catalyzes hydroxylation of actin at proline residues 307 and 322.	Proline	134-141	egl-9 family hypoxia inducible factor 3	Homo sapiens	20-40
25079693-2	2014	Here we report that prolyl hydroxylase 3 (PHD3) interacts with nonmuscle actin in human cells and catalyzes hydroxylation of actin at proline residues 307 and 322.	Proline	134-141	egl-9 family hypoxia inducible factor 3	Homo sapiens	42-46
25203209-2	2014	We demonstrate that Ena/VASP and the WRC control actin polymerization in a cooperative manner through the interaction of the Ena/VASP EVH1 domain with an extended proline rich motif in Abi.	Proline	163-170	vasodilator-stimulated phosphoprotein	Rattus norvegicus	24-28
25203209-2	2014	We demonstrate that Ena/VASP and the WRC control actin polymerization in a cooperative manner through the interaction of the Ena/VASP EVH1 domain with an extended proline rich motif in Abi.	Proline	163-170	vasodilator-stimulated phosphoprotein	Rattus norvegicus	129-133
25058871-5	2014	These overlapped metabolites show that decreased alanine asparate and glutamate metabolic pathway, arginine and proline metabolic pathway, and increased purine metabolism form a characteristic feature in response to IFN-alpha2b.	Proline	112-119	interferon phi 1	Danio rerio	216-219
25186736-5	2014	We found that BChE is anchored at the TSC by a proline-rich membrane anchor, the small transmembrane protein anchor of brain AChE.	Proline	47-54	butyrylcholinesterase	Homo sapiens	14-18
25186736-5	2014	We found that BChE is anchored at the TSC by a proline-rich membrane anchor, the small transmembrane protein anchor of brain AChE.	Proline	47-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	125-129
25159840-1	2014	Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1) modulates phospho-signaling by catalyzing rotation of the bond between a phosphorylated serine or threonine before proline in proteins.	Proline	177-184	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	56-60
25042242-0	2014	Can proline-rich polypeptide complex mimic the effect of nerve growth factor?	Proline	4-11	nerve growth factor	Rattus norvegicus	57-76
24916123-3	2014	MIF has an unusual N-terminal proline with catalytic activity, and targeting of this residue by small-molecule inhibitors has been shown to interfere with the biological activity of MIF.	Proline	30-37	macrophage migration inhibitory factor	Homo sapiens	0-3
24916123-3	2014	MIF has an unusual N-terminal proline with catalytic activity, and targeting of this residue by small-molecule inhibitors has been shown to interfere with the biological activity of MIF.	Proline	30-37	macrophage migration inhibitory factor	Homo sapiens	182-185
24916123-8	2014	We have characterized the modification introduced by oxidized (-)-epicatechin on MIF by LC-MS (liquid chromatography MS) and found it to occur at the N-terminal proline.	Proline	161-168	macrophage migration inhibitory factor	Homo sapiens	81-84
24986180-8	2014	Prion protein (PrP) gene analysis revealed a Pro to Leu point mutation at codon 102 with methionine homozygosity at codon 129.	Proline	45-48	prion protein	Homo sapiens	15-18
25091930-3	2014	The potency of the carboxylate series is now further improved through structure-based optimization of ligand-protein interactions in the proline binding site which exploits the H-bond interactions necessary for Pin1 catalytic function.	Proline	137-144	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	211-215
25124924-2	2014	Protein interacting with never in mitosis A1 (Pin1), which is overexpressed in many types of cancer, isomerizes specific phosphorylated Ser/Thr-Pro bonds in many substrate proteins, including glycolytic enzyme, protein kinases, protein phosphatases, methyltransferase, lipid kinase, ubiquitin E3 ligase, DNA endonuclease, RNA polymerase, and transcription activators and regulators.	Proline	0-3	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	46-50
25120724-1	2014	Peptidyl-prolylcis-trans isomerase NIMA-interacting 1 (encoded by the PIN1 gene) regulates the conformation of proline-directed phosphorylation sites and is important in the etiology of cancer.	Proline	111-118	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	70-74
25029904-4	2014	In this review, we provide a summary of recent data that have identified a novel role for the translation factor eIF5A and its hypusine modification in the elongation phase of protein synthesis and more specifically in stimulating the production of proteins containing runs of consecutive proline residues.	Proline	289-296	eukaryotic translation initiation factor 5A	Homo sapiens	113-118
24659417-1	2014	Cyclin-dependent kinase 5 (Cdk5) is a member of the small proline-directed serine/threonine kinase family.	Proline	58-65	cyclin-dependent kinase 5	Rattus norvegicus	0-25
24659417-1	2014	Cyclin-dependent kinase 5 (Cdk5) is a member of the small proline-directed serine/threonine kinase family.	Proline	58-65	cyclin-dependent kinase 5	Rattus norvegicus	27-31
24563226-1	2014	Cdk5 is a member of cyclin-dependent kinase (Cdk), a proline-directed serine/threonine kinase, and plays a key role in normal neural development and function.	Proline	53-60	cyclin-dependent kinase 5	Rattus norvegicus	0-4
25181455-2	2014	This study was conducted to identify the most potent ACE-inhibitory tripeptides with a proline C-terminus, using a novel three-step (tautomerization-docking-ADME simulation) virtual screening process and in vitro assays.	Proline	87-94	angiotensin I converting enzyme	Homo sapiens	53-56
24991000-3	2014	Inspection of the CA sequences of lentiviruses reveals that several species of simian immunodeficiency viruses (SIVs) have lost the glycine-proline motif in the helix 4-5 loop important for CypA binding; instead, the helix 4-5 loop in these SIVs exhibits an increase in the number of glutamine residues.	Proline	140-147	peptidylprolyl isomerase A	Homo sapiens	190-194
25072537-4	2014	In the present study we functionally characterize a proline-rich region of nmMLCK previously identified as the possible site of interaction between nmMLCK and cortactin.	Proline	52-59	cortactin	Homo sapiens	159-168
25072537-5	2014	A mutant nmMLCK construct deficient in proline residues at the putative sites of cortactin binding (amino acids 973, 976, 1019, 1022) was generated.	Proline	39-46	cortactin	Homo sapiens	81-90
25072537-7	2014	In contrast, binding studies utilizing recombinant nmMLCK fragments containing the wild-type or proline-deficient sequence demonstrated a two-fold increase in cortactin binding (p&lt;0.01) to the mutant construct.	Proline	96-103	cortactin	Homo sapiens	159-168
25536560-2	2014	To set of p53-mediated apoptosis gene polymorphisms (TP53 codon 72 Arg/Pro, r21 codon 31 Ser/Arg, MDM2 SNP309) for the occurrence of CLL in patients who were exposed to ionizing radiation (IR) from the Chornobyl accident.	Proline	71-74	tumor protein p53	Homo sapiens	10-13
25099801-7	2014	Residues lining this cavity in EAAT1, including Ser-366, Leu-369, Phe-373, Arg-388, Pro-392, and Thr-396, were mutated to small hydrophobic residues.	Proline	84-87	solute carrier family 1 member 3	Homo sapiens	31-36
25258482-4	2014	The G915C polymorphism changes codon 25 which encodes arginine into proline in the signal peptide of TGF-beta1.	Proline	68-75	transforming growth factor beta 1	Homo sapiens	101-110
25258482-7	2014	The arginine substitution into proline decreased the polarity of the signal peptide for TGF-beta1.	Proline	31-38	transforming growth factor beta 1	Homo sapiens	88-97
25216532-3	2014	Our earlier studies revealed that a proline-rich segment of apoptin interacts with the SH3 domain of fusion protein BCR-ABL1 (p210) and acts as a negative regulator of BCR-ABL1 kinase and its downstream targets.	Proline	36-43	BCR activator of RhoGEF and GTPase	Homo sapiens	116-124
25216532-3	2014	Our earlier studies revealed that a proline-rich segment of apoptin interacts with the SH3 domain of fusion protein BCR-ABL1 (p210) and acts as a negative regulator of BCR-ABL1 kinase and its downstream targets.	Proline	36-43	BCR activator of RhoGEF and GTPase	Homo sapiens	168-176
25177931-6	2014	TP53 72 showed the following genotypic distribution: the control group was 29.75% homozygous wild-type (Arg), 47.11% heterozygous (Arg-Pro), and 23.14% homozygous variant (Pro).	Proline	135-138	tumor protein p53	Homo sapiens	0-4
25006245-4	2014	Furthermore, we present several lines of evidence suggesting that luminal calcium affected transport at least in part through calcium-dependent interactions between apoptosis-linked gene-2 (ALG-2) and the Sec31A proline-rich region: 1) targeted disruption of ALG-2/Sec31A interactions caused severe defects in ER-to-Golgi transport in intact cells; 2) effects of luminal calcium and ALG-2/Sec31A interactions on transport mutually required each other; and 3) Sec31A function in transport required luminal calcium.	Proline	212-219	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	190-195
25006245-4	2014	Furthermore, we present several lines of evidence suggesting that luminal calcium affected transport at least in part through calcium-dependent interactions between apoptosis-linked gene-2 (ALG-2) and the Sec31A proline-rich region: 1) targeted disruption of ALG-2/Sec31A interactions caused severe defects in ER-to-Golgi transport in intact cells; 2) effects of luminal calcium and ALG-2/Sec31A interactions on transport mutually required each other; and 3) Sec31A function in transport required luminal calcium.	Proline	212-219	SEC31 homolog A, COPII coat complex component	Homo sapiens	205-211
25059768-1	2014	Pin1 is an enzyme that specifically catalyzes the cis-trans isomerization of proline amide bonds in peptides that contain a phosphorylated threonine or serine residue in the position preceding proline.	Proline	77-84	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
25059768-1	2014	Pin1 is an enzyme that specifically catalyzes the cis-trans isomerization of proline amide bonds in peptides that contain a phosphorylated threonine or serine residue in the position preceding proline.	Proline	193-200	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
24929581-1	2014	PR-39 is a gene-encoded, proline-arginine-rich porcine antimicrobial peptide with multiple biological functions.	Proline	25-32	antibacterial protein PR-39	Sus scrofa	0-5
24939844-2	2014	The Mcl-1 protein contains PEST sequences (enriched in proline, glutamic acid, serine, and threonine) and is normally subject to rapid turnover via multiple different pathways.	Proline	55-62	induced myeloid leukemia cell differentiation protein Mcl-1	Cricetulus griseus	4-9
25031324-5	2014	PKA-dependent proline resonances were lost in the presence of the Src homology 3 domain of c-Src, consistent with formation of a complex.	Proline	14-21	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	91-96
25137142-0	2014	The cytoplasmic capping complex assembles on adapter protein nck1 bound to the proline-rich C-terminus of Mammalian capping enzyme.	Proline	79-86	NCK adaptor protein 1	Homo sapiens	61-65
25137142-2	2014	We identify the proline-rich C-terminus as a new domain of CE that is required for its participation in cytoplasmic capping, and show the cytoplasmic capping complex assembles on Nck1, an adapter protein with functions in translation and tyrosine kinase signaling.	Proline	16-23	NCK adaptor protein 1	Homo sapiens	179-183
24923804-4	2014	We also show that eIF5A is required for the translation of Bni1, a proline-rich formin involved in polarized growth during shmoo formation.	Proline	67-74	eukaryotic translation initiation factor 5A	Homo sapiens	18-23
25090004-0	2014	The influence of pathological mutations and proline substitutions in TDP-43 glycine-rich peptides on its amyloid properties and cellular toxicity.	Proline	44-51	TAR DNA binding protein	Homo sapiens	69-75
25083109-11	2014	Moreover, proline supplementation increased diamine oxidase (DAO) concentrations after LPS challenge (p&lt;0.05).	Proline	10-17	amine oxidase copper containing 1	Sus scrofa	44-59
25083109-11	2014	Moreover, proline supplementation increased diamine oxidase (DAO) concentrations after LPS challenge (p&lt;0.05).	Proline	10-17	amine oxidase copper containing 1	Sus scrofa	61-64
24923804-4	2014	We also show that eIF5A is required for the translation of Bni1, a proline-rich formin involved in polarized growth during shmoo formation.	Proline	67-74	formin BNI1	Saccharomyces cerevisiae S288C	59-63
23475592-2	2014	This SNP encodes either an arginine or proline at position 72 (R72P) of the p53 protein, which can alter the apoptotic activity of p53 via transcriptional and non-transcriptional mechanisms.	Proline	39-46	tumor protein p53	Homo sapiens	76-79
24962087-4	2014	To illustrate that function can be readily introduced using a modular approach, l-proline-based BTAs are incorporated to procure a catalytically active SCPN in water.	Proline	80-89	carboxypeptidase N subunit 1	Homo sapiens	152-156
24878663-6	2014	Our NMR and ITC data indicate that the SH3a and SH3b domains of CAP simultaneously bind to a long proline-rich region of vinculin with different binding specificities.	Proline	98-105	sorbin and SH3 domain containing 1	Homo sapiens	64-67
24878663-6	2014	Our NMR and ITC data indicate that the SH3a and SH3b domains of CAP simultaneously bind to a long proline-rich region of vinculin with different binding specificities.	Proline	98-105	vinculin	Homo sapiens	121-129
23475592-2	2014	This SNP encodes either an arginine or proline at position 72 (R72P) of the p53 protein, which can alter the apoptotic activity of p53 via transcriptional and non-transcriptional mechanisms.	Proline	39-46	tumor protein p53	Homo sapiens	131-134
25062106-4	2014	A novel missense mutation identified at C1744T (582 Pro &gt; Ser) position of GRM1 gene in a primary AA-PCa cell line (E006AA) was predicted to affect the protein stability and functions.	Proline	52-55	glutamate metabotropic receptor 1	Homo sapiens	78-82
24912681-9	2014	We identified a novel proline-tyrosine nuclear localization signal (PY-NLS) in DJ-1, and we found that nuclear monomeric DJ-1 import is mediated by an oxidative stress-dependent interaction with karyopherin beta2.	Proline	22-29	Parkinsonism associated deglycase	Homo sapiens	79-83
24912681-9	2014	We identified a novel proline-tyrosine nuclear localization signal (PY-NLS) in DJ-1, and we found that nuclear monomeric DJ-1 import is mediated by an oxidative stress-dependent interaction with karyopherin beta2.	Proline	22-29	Parkinsonism associated deglycase	Homo sapiens	121-125
24912681-9	2014	We identified a novel proline-tyrosine nuclear localization signal (PY-NLS) in DJ-1, and we found that nuclear monomeric DJ-1 import is mediated by an oxidative stress-dependent interaction with karyopherin beta2.	Proline	22-29	transportin 1	Homo sapiens	195-212
25078403-7	2014	In addition, we found that in DRD4 in Naganakidori, there is a deletion variant of one proline at the 24th residue in the repeat of nine prolines of exon 1.	Proline	87-94	dopamine receptor D4	Gallus gallus	30-34
25161874-1	2014	4-Oxalocrotonate tautomerase (4-OT) catalyzes the enol-keto tautomerization of 2-hydroxymuconate, utilizing its N-terminal proline (Pro-1) as general base catalyst.	Proline	123-130	4-oxalocrotonate tautomerase	Escherichia coli	0-28
25184115-10	2014	Thus proline oxidation by proline dehydrogenase drives superoxide/H2O2 production, but it does so mainly or exclusively by providing anaplerotic carbon for other mitochondrial dehydrogenases and not by producing superoxide/H2O2 directly.	Proline	5-12	proline dehydrogenase 1	Homo sapiens	26-47
23975430-2	2014	PELP1 (proline, glutamic acid and leucine rich protein 1) is a nuclear receptor coregulator that is upregulated during breast cancer progression to metastasis and is an independent prognostic predictor of shorter survival of breast cancer patients.	Proline	7-14	proline, glutamate and leucine rich protein 1	Homo sapiens	0-5
24958857-3	2014	Here, we identify apoptosis-stimulating protein of p53 with signature sequences of ankyrin repeat-, SH3 domain-, and proline-rich region-containing protein 2 (ASPP2), a haploinsufficient tumor suppressor, activator of p53, and regulator of cell polarity, as a transcriptional target of signal transducer and activator of transcription 1 (STAT1).	Proline	117-124	tumor protein p53	Homo sapiens	51-54
25027299-9	2014	A common feature across Ataxin-2 orthologs is the presence of proline-rich motifs, formerly described in the human protein.	Proline	62-69	ataxin 2	Homo sapiens	24-32
25027299-11	2014	Proline-rich motifs that may mediate protein interactions are widespread in Ataxin-2 proteins, but expansion of polyglutamine tracts associated with spinocerebellar ataxia type 2, is present only in primates, as well as some insects.	Proline	0-7	ataxin 2	Homo sapiens	76-84
24958857-3	2014	Here, we identify apoptosis-stimulating protein of p53 with signature sequences of ankyrin repeat-, SH3 domain-, and proline-rich region-containing protein 2 (ASPP2), a haploinsufficient tumor suppressor, activator of p53, and regulator of cell polarity, as a transcriptional target of signal transducer and activator of transcription 1 (STAT1).	Proline	117-124	tumor protein p53 binding protein 2	Homo sapiens	159-164
24799612-8	2014	Because the 2 protein kinases, STE20p-related proline- and alanine-rich kinase (encoded by STK39) and oxidative stress-response kinase 1, phosphorylate and activate NCC, we examined their roles in norepinephrine effects.	Proline	46-53	serine/threonine kinase 24	Mus musculus	31-37
24703937-8	2014	When STAT3 was mutated at S727 to proline (S727P), the mutant STAT3 S727P did not interact with C/EBPalpha.	Proline	34-41	signal transducer and activator of transcription 3	Homo sapiens	5-10
24703937-8	2014	When STAT3 was mutated at S727 to proline (S727P), the mutant STAT3 S727P did not interact with C/EBPalpha.	Proline	34-41	signal transducer and activator of transcription 3	Homo sapiens	62-67
32481031-1	2014	The protein encoded by AtDHyPRP1 (DOUBLE HYBRID PROLINE-RICH PROTEIN 1) contains two tandem PRD-8CMs (proline-rich domain-eight cysteine motif) and represents a new type of HyPRPs (hybrid proline-rich proteins).	Proline	102-109	proline-rich protein 1	Arabidopsis thaliana	48-70
32481031-1	2014	The protein encoded by AtDHyPRP1 (DOUBLE HYBRID PROLINE-RICH PROTEIN 1) contains two tandem PRD-8CMs (proline-rich domain-eight cysteine motif) and represents a new type of HyPRPs (hybrid proline-rich proteins).	Proline	188-195	proline-rich protein 1	Arabidopsis thaliana	48-70
24874071-0	2014	An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease.	Proline	37-44	leukotriene A4 hydrolase	Mus musculus	12-36
24874071-0	2014	An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease.	Proline	53-60	leukotriene A4 hydrolase	Mus musculus	12-36
24874071-3	2014	OBJECTIVES: We investigated changes to the leukotriene A4 hydrolase (LTA4H)-proline-glycine-proline (PGP) pathway and chronic inflammation in the development of COPD.	Proline	76-83	leukotriene A4 hydrolase	Mus musculus	43-67
24874071-3	2014	OBJECTIVES: We investigated changes to the leukotriene A4 hydrolase (LTA4H)-proline-glycine-proline (PGP) pathway and chronic inflammation in the development of COPD.	Proline	76-83	leukotriene A4 hydrolase	Mus musculus	69-74
24799612-8	2014	Because the 2 protein kinases, STE20p-related proline- and alanine-rich kinase (encoded by STK39) and oxidative stress-response kinase 1, phosphorylate and activate NCC, we examined their roles in norepinephrine effects.	Proline	46-53	serine/threonine kinase 39	Mus musculus	91-96
24799612-10	2014	We confirmed that STE20p-related proline- and alanine-rich kinase is not required for NCC activation, using STK39 knockout mice.	Proline	33-40	serine/threonine kinase 24	Mus musculus	18-24
25187461-3	2014	RESULTS: The bioinformatic analysis revealed that proline content was the highest of all amino acid residues in PYGO1 protein; the molecular formula was C(1943)H(2937)N(577)O(635)S(18) with a relative molecular mass of 45; and the theoretical isoelectric point was 6.38.	Proline	50-57	pygopus family PHD finger 1	Homo sapiens	112-117
24612677-3	2014	The major AChE variant expressed in the brain is a tetramer (G(4)) bound to a proline-rich membrane anchor (PRiMA).	Proline	78-85	acetylcholinesterase	Mus musculus	10-14
24612677-3	2014	The major AChE variant expressed in the brain is a tetramer (G(4)) bound to a proline-rich membrane anchor (PRiMA).	Proline	78-85	proline rich membrane anchor 1	Mus musculus	108-113
24752542-3	2014	Within the intracellular portion, ROR1 possesses a tyrosine kinase domain, two serine/threonine-rich domains and a proline-rich domain.	Proline	115-122	receptor tyrosine kinase like orphan receptor 1	Homo sapiens	34-38
24752897-5	2014	Here, we identify proline, glutamic acid, and leucine-rich protein 1 (PELP1), a chromatin-associated factor and transcriptional coregulator, as a ligand-independent macrodomain-interacting factor.	Proline	18-25	proline, glutamate and leucine rich protein 1	Homo sapiens	70-75
24970086-4	2014	NM23-H1/H2 localized at clathrin-coated pits and interacted with the proline-rich domain of dynamin.	Proline	69-76	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-7
24980702-3	2014	We demonstrate the utility of the GNN approach by predicting in vitro activities and in vivo functions in the proline racemase superfamily (PRS; InterPro IPR008794).	Proline	110-117	tetratricopeptide repeat domain 41, pseudogene	Homo sapiens	34-37
24971589-2	2014	Lineage/intra-lineage geographic variants exhibit consistent amino acid polymorphisms at this locus; however, the majority of WNV isolates associated with recent outbreaks reported worldwide have a proline at the NS3-249 residue.	Proline	198-205	KRAS proto-oncogene, GTPase	Homo sapiens	213-216
24889612-5	2014	The structures show that PILRalpha exhibits large conformational change to recognize simultaneously both the sTn O-glycan and the compact peptide structure constrained by proline residues.	Proline	171-178	paired immunoglobin like type 2 receptor alpha	Homo sapiens	25-34
24840168-3	2014	Pin1 is a cis-trans isomerase of peptidyl-prolyl(omega-) bonds of phosphorylated-Ser/Thr-Pro motifs and has been implicated in many diseases.	Proline	89-92	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
24474455-8	2014	The Arg72Pro-p53 polymorphism showed for the genotypes Arg/Pro and Pro/Pro, and for the Pro allele, a significant association only to the risk for CIN (p&lt;0.03).	Proline	9-12	tumor protein p53	Homo sapiens	13-16
24474455-8	2014	The Arg72Pro-p53 polymorphism showed for the genotypes Arg/Pro and Pro/Pro, and for the Pro allele, a significant association only to the risk for CIN (p&lt;0.03).	Proline	59-62	tumor protein p53	Homo sapiens	13-16
24474455-8	2014	The Arg72Pro-p53 polymorphism showed for the genotypes Arg/Pro and Pro/Pro, and for the Pro allele, a significant association only to the risk for CIN (p&lt;0.03).	Proline	59-62	tumor protein p53	Homo sapiens	13-16
24770418-4	2014	Binding to and inhibition of the proteasome by PI31 are conferred by the HbYX-containing proline-rich C-terminal domain but do not require HbYX residues.	Proline	89-96	proteasome inhibitor subunit 1	Homo sapiens	47-51
24815698-3	2014	Herein, we report the presence of a SH3 binding motif in the proline rich unfolded ErbB2 C-terminal region.	Proline	61-68	erb-b2 receptor tyrosine kinase 2	Homo sapiens	83-88
24982848-1	2014	The peptidyl-prolyl cis/trans isomerase Pin1 acts as a molecular timer in proline-directed Ser/Thr kinase signaling and shapes cellular responses based on recognition of phosphorylation marks and implementing conformational changes in its substrates.	Proline	74-81	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	40-44
24582589-7	2014	Src-aPKC interaction was essential; substitution of the proline residues in aPKC that associate with the Src-SH3 binding domain rendered the mutant kinase unable to induce macropinocytosis in transfected cells.	Proline	56-63	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
24710610-2	2014	A common polymorphism of the encoding TP53 gene (codon 72, Pro &gt; Arg, rs1042522) is associated with susceptibility to virus-related and other cancers.	Proline	59-62	tumor protein p53	Homo sapiens	38-42
24582589-7	2014	Src-aPKC interaction was essential; substitution of the proline residues in aPKC that associate with the Src-SH3 binding domain rendered the mutant kinase unable to induce macropinocytosis in transfected cells.	Proline	56-63	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-108
24801343-6	2014	In Arabidopsis, KASH proteins also interact with the tryptophan-proline-proline (WPP) domain-interacting tail-anchored protein 1 (WIT1), associated with the nuclear pore complex and with myosin XI-i which directly interacts with the actin cytoskeleton.	Proline	64-71	WPP domain-interacting protein 1	Arabidopsis thaliana	130-134
24801343-6	2014	In Arabidopsis, KASH proteins also interact with the tryptophan-proline-proline (WPP) domain-interacting tail-anchored protein 1 (WIT1), associated with the nuclear pore complex and with myosin XI-i which directly interacts with the actin cytoskeleton.	Proline	64-71	myosin	Arabidopsis thaliana	187-193
24801343-6	2014	In Arabidopsis, KASH proteins also interact with the tryptophan-proline-proline (WPP) domain-interacting tail-anchored protein 1 (WIT1), associated with the nuclear pore complex and with myosin XI-i which directly interacts with the actin cytoskeleton.	Proline	72-79	WPP domain-interacting protein 1	Arabidopsis thaliana	130-134
24801343-6	2014	In Arabidopsis, KASH proteins also interact with the tryptophan-proline-proline (WPP) domain-interacting tail-anchored protein 1 (WIT1), associated with the nuclear pore complex and with myosin XI-i which directly interacts with the actin cytoskeleton.	Proline	72-79	myosin	Arabidopsis thaliana	187-193
24043471-6	2014	C. albicans SOD1 contains a proline at position 144 predicted to dictate dependence on CCS1.	Proline	28-35	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	12-16
24699213-6	2014	Moreover, by up-regulating Bip, cyclo(His-Pro) increases the ER stress sensitivity and triggers the unfolded protein response to alleviate the ER stress.	Proline	42-45	heat shock protein family A (Hsp70) member 5	Homo sapiens	27-30
24700120-5	2014	The presence of a proline residue contributes to an increased yield of ISD fragments originating from N-Calpha bond cleavage at Xxx1-Xxx2Pro, which is attributable to the cyclic structure of the proline residue.	Proline	18-25	CEA cell adhesion molecule 4	Homo sapiens	102-110
24700120-5	2014	The presence of a proline residue contributes to an increased yield of ISD fragments originating from N-Calpha bond cleavage at Xxx1-Xxx2Pro, which is attributable to the cyclic structure of the proline residue.	Proline	195-202	CEA cell adhesion molecule 4	Homo sapiens	102-110
24699213-4	2014	We found that systemic administration of cyclo(His-Pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFalpha expression thereby counteracting LPS-induced gliosis.	Proline	51-54	tumor necrosis factor	Homo sapiens	167-175
24043471-6	2014	C. albicans SOD1 contains a proline at position 144 predicted to dictate dependence on CCS1.	Proline	28-35	copper chaperone CCS1	Saccharomyces cerevisiae S288C	87-91
24043471-7	2014	By mutation of this proline, C. albicans SOD1 gained activity in S. cerevisiae, and this activity was independent of CCS1.	Proline	20-27	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	41-45
24043471-7	2014	By mutation of this proline, C. albicans SOD1 gained activity in S. cerevisiae, and this activity was independent of CCS1.	Proline	20-27	copper chaperone CCS1	Saccharomyces cerevisiae S288C	117-121
24470260-2	2014	This atypical serine protease has both dipeptidyl peptidase and endopeptidase activities, cleaving substrates at a post-proline bond.	Proline	120-127	coagulation factor II, thrombin	Homo sapiens	14-29
24951479-4	2014	This gene encodes a Delta1-pyrroline-5- carboxylate synthetase that catalyzes the biosynthesis of proline from glutamic acid.	Proline	98-105	Delta-1-pyrroline-5-carboxylate synthase 2	Zea mays	26-62
24973301-2	2014	Here, we focused on proline and GGG (anticodon of tRNA(Pro)) and investigated their mutual interaction.	Proline	20-27	mitochondrially encoded tRNA glycine	Homo sapiens	50-59
24819565-10	2014	This mutation is undoubtedly associated with increased HIF-2alpha activity and increased protein half-life, because it affects the vicinity of the prolyl hydroxylase target residue, proline 531.	Proline	182-189	endothelial PAS domain protein 1	Homo sapiens	55-65
24700463-3	2014	The cytosolic tail of SelS consists of a coiled-coil domain, a putative VCP-interacting motif (VIM), and an unpronounced glycine- and proline-rich secondary structure.	Proline	134-141	selenoprotein S	Homo sapiens	22-26
24787057-3	2014	PRODH maps to chromosome 22q11, a region conferring the highest known genetic risk of schizophrenia, and encodes proline oxidase, which catalyzes proline catabolism.	Proline	113-120	proline dehydrogenase 1	Homo sapiens	0-5
24787057-9	2014	This study presents a mechanism by which 25(OH)D insufficiency confers risk of schizophrenia; via proline elevation due to reduced PRODH expression, and a concomitant dysregulation of neurotransmission.	Proline	98-105	proline dehydrogenase 1	Homo sapiens	131-136
24398893-7	2014	The physiological studies revealed that the expression of AtDREB1A was associated with an increased accumulation of the osmotic substance proline, maintenance of chlorophyll, increased relative water content and decreased ion leakage under drought stress.	Proline	138-145	dehydration response element B1A	Arabidopsis thaliana	58-66
24700463-12	2014	These results suggest that both Pro(178) and Pro(183) of SelS play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress.	Proline	45-48	selenoprotein S	Homo sapiens	57-61
24700463-12	2014	These results suggest that both Pro(178) and Pro(183) of SelS play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress.	Proline	45-48	valosin containing protein	Homo sapiens	107-110
24930674-0	2014	Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production.	Proline	110-117	LTO1 maturation factor of ABCE1	Homo sapiens	26-32
24930674-8	2014	The peptide mass fingerprinting technique demonstrated that ORAOV1 bound to pyrroline-5-carboxylate reductase (PYCR), which is associated with proline metabolism and reactive oxygen species (ROS) production.	Proline	143-150	LTO1 maturation factor of ABCE1	Homo sapiens	60-66
24930674-8	2014	The peptide mass fingerprinting technique demonstrated that ORAOV1 bound to pyrroline-5-carboxylate reductase (PYCR), which is associated with proline metabolism and reactive oxygen species (ROS) production.	Proline	143-150	pyrroline-5-carboxylate reductase 1	Homo sapiens	76-109
24930674-8	2014	The peptide mass fingerprinting technique demonstrated that ORAOV1 bound to pyrroline-5-carboxylate reductase (PYCR), which is associated with proline metabolism and reactive oxygen species (ROS) production.	Proline	143-150	pyrroline-5-carboxylate reductase 1	Homo sapiens	111-115
24930674-10	2014	In addition, the ORAOV1-overexpressed cell line had a higher intracellular proline concentration and a lower ROS level.	Proline	75-82	LTO1 maturation factor of ABCE1	Homo sapiens	17-23
24930674-11	2014	Our findings indicate that the ORAOV1 gene is frequently amplified in ESCC, enhances tumorigenicity and tumor growth, and is associated with a poorly differentiated tumor histology via proline metabolism and ROS production.	Proline	185-192	LTO1 maturation factor of ABCE1	Homo sapiens	31-37
24700463-12	2014	These results suggest that both Pro(178) and Pro(183) of SelS play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress.	Proline	45-48	valosin containing protein	Homo sapiens	111-114
24700463-10	2014	However, mutants in which the proline residue positions 178 or 183 of SelS were changed to alanine or were deleted did not interact with p97(VCP).	Proline	30-37	selenoprotein S	Homo sapiens	70-74
24700463-12	2014	These results suggest that both Pro(178) and Pro(183) of SelS play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress.	Proline	32-35	selenoprotein S	Homo sapiens	57-61
24700463-12	2014	These results suggest that both Pro(178) and Pro(183) of SelS play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress.	Proline	32-35	valosin containing protein	Homo sapiens	107-110
24700463-12	2014	These results suggest that both Pro(178) and Pro(183) of SelS play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress.	Proline	32-35	valosin containing protein	Homo sapiens	111-114
24816797-1	2014	Nemo-like kinase (NLK), a proline-directed serine/threonine kinase regulated by phosphorylation, can be localized in the cytosol or in the nucleus.	Proline	26-33	nemo like kinase	Homo sapiens	0-16
24412428-1	2014	Here, an ultrasensitive electrochemiluminescence (ECL) aptasensor using in situ generated proline and polyamidoamine (PAMAM) dendrimers as coreactant for bis(2,2"-bipyridyl)(5-amino-1,10-phenanthroline) ruthenium(II) (Ru) was successfully constructed for detection of thrombin (TB).	Proline	90-97	coagulation factor II, thrombin	Homo sapiens	268-276
24828240-10	2014	The proline-rich domain in Pop2 resembles an aggresome targeting signal, so Pop2 may act in trans to positively impact spatial quality control of Htt103Q.	Proline	4-11	pyrin domain containing 2	Homo sapiens	27-31
24828240-10	2014	The proline-rich domain in Pop2 resembles an aggresome targeting signal, so Pop2 may act in trans to positively impact spatial quality control of Htt103Q.	Proline	4-11	pyrin domain containing 2	Homo sapiens	76-80
24884657-5	2014	The functional status of the new p53 protein, which has a defect in its proline-rich and N-terminal DNA-binding domains, was characterized as possessing an intact conformation, exhibiting no transactivation activity, exerting a dominant-negative effect and an interacting with a coactivator with an arginine methyltransferase activity.	Proline	72-79	transformation related protein 53, pseudogene	Mus musculus	33-36
24816797-1	2014	Nemo-like kinase (NLK), a proline-directed serine/threonine kinase regulated by phosphorylation, can be localized in the cytosol or in the nucleus.	Proline	26-33	nemo like kinase	Homo sapiens	18-21
24753571-3	2014	Most Trn1 cargos bear a well-characterized proline-tyrosine-NLS, which is missing from the dsRBD-NLS.	Proline	43-50	transportin 1	Homo sapiens	5-9
24887198-10	2014	The frequencies for GPx1 Pro198Leu polymorphism were 55%, 38% and 7% for Pro/Pro, Pro/Leu and Leu/Leu, respectively.	Proline	25-28	glutathione peroxidase 1	Homo sapiens	20-24
24887198-10	2014	The frequencies for GPx1 Pro198Leu polymorphism were 55%, 38% and 7% for Pro/Pro, Pro/Leu and Leu/Leu, respectively.	Proline	73-76	glutathione peroxidase 1	Homo sapiens	20-24
24809345-5	2014	In turn, Siah1/2 attenuates proline hydroxylation of ATF4, resulting in its stabilization, thereby augmenting ER stress output.	Proline	28-35	siah E3 ubiquitin protein ligase 2	Mus musculus	9-16
24809345-5	2014	In turn, Siah1/2 attenuates proline hydroxylation of ATF4, resulting in its stabilization, thereby augmenting ER stress output.	Proline	28-35	activating transcription factor 4	Mus musculus	53-57
24768113-1	2014	The Na(+)/proline symporter (PutP), like several other Na(+)-coupled symporters, belongs to the so-called LeuT-fold structural family, which features ten core transmembrane domains (cTMs) connected by extra- and intracellular loops.	Proline	10-17	Leucine transport, high	Homo sapiens	106-110
24689873-8	2014	Further analysis revealed that CBP20/80 regulated the splicing of genes involved in proline and sugar metabolism and that the epigenetic and post-translational modifications of these genes were involved in salt stress tolerance.	Proline	84-91	CAP-binding protein 20	Arabidopsis thaliana	31-36
24644294-5	2014	Cleavage occurred between Pro-1244 and Ala-1245 within Reelin repeat 3.	Proline	26-29	reelin	Homo sapiens	55-61
24657892-3	2014	Pin1 specifically isomerizes the phosphorylated protein with Ser/Thr-Pro bonds and regulates their activity through conformational changes.	Proline	69-72	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Rattus norvegicus	0-4
24440425-5	2014	The sequence containing residues L962 to Y976 of the TMD of the IR in micelles adopts a well-defined helical structure with a kink formed by glycine and proline residues present at its N-terminus, which might be important for its function.	Proline	153-160	insulin receptor	Homo sapiens	64-66
24122396-2	2014	The effect of protein and chemical chaperones and crowders on thermal stability and aggregation of apoform of rabbit muscle glycogen phosphorylase b (apoPhb) has been studied at 37 C. Proline suppressed heat-induced loss in ability of apoPhb to reconstitution at 37 C, whereas alpha-crystallin did not reveal a protective action.	Proline	184-191	LOW QUALITY PROTEIN: glycogen phosphorylase, brain form	Oryctolagus cuniculus	124-148
24620000-6	2014	In addition, four AtRALF1-inducible genes were identified: two genes encoding proline-rich proteins (AtPRP1 and AtPRP3), one encoding a hydroxyproline-rich glycoprotein (AtHRPG2), and one encoding a xyloglucan endotransglucosylase (TCH4).	Proline	78-85	rapid alkalinization factor 1	Arabidopsis thaliana	18-25
24508479-3	2014	In this study, we show that the C-terminal proline-rich region of Dock4 is essential for the Dock4 mediated promotion of cell migration in MDA-MB-231 breast cancer cells.	Proline	43-50	dedicator of cytokinesis 4	Homo sapiens	66-71
24508479-3	2014	In this study, we show that the C-terminal proline-rich region of Dock4 is essential for the Dock4 mediated promotion of cell migration in MDA-MB-231 breast cancer cells.	Proline	43-50	dedicator of cytokinesis 4	Homo sapiens	93-98
24508479-4	2014	We found that a phosphoinositide-binding protein SH3YL1 interacted with the C-terminal proline-rich region of Dock4.	Proline	87-94	Sh3 domain YSC-like 1	Mus musculus	49-55
24508479-4	2014	We found that a phosphoinositide-binding protein SH3YL1 interacted with the C-terminal proline-rich region of Dock4.	Proline	87-94	dedicator of cytokinesis 4	Mus musculus	110-115
24516103-2	2014	Dipeptidyl peptidase-4 degrades other peptides with a penultimate proline or alanine, including bradykinin and substance P, which are also substrates of angiotensin-converting enzyme (ACE).	Proline	66-73	dipeptidyl peptidase 4	Homo sapiens	0-22
24516103-2	2014	Dipeptidyl peptidase-4 degrades other peptides with a penultimate proline or alanine, including bradykinin and substance P, which are also substrates of angiotensin-converting enzyme (ACE).	Proline	66-73	kininogen 1	Homo sapiens	96-106
24516103-2	2014	Dipeptidyl peptidase-4 degrades other peptides with a penultimate proline or alanine, including bradykinin and substance P, which are also substrates of angiotensin-converting enzyme (ACE).	Proline	66-73	tachykinin precursor 1	Homo sapiens	111-122
24516103-2	2014	Dipeptidyl peptidase-4 degrades other peptides with a penultimate proline or alanine, including bradykinin and substance P, which are also substrates of angiotensin-converting enzyme (ACE).	Proline	66-73	angiotensin I converting enzyme	Homo sapiens	153-182
24516103-2	2014	Dipeptidyl peptidase-4 degrades other peptides with a penultimate proline or alanine, including bradykinin and substance P, which are also substrates of angiotensin-converting enzyme (ACE).	Proline	66-73	angiotensin I converting enzyme	Homo sapiens	184-187
24554436-0	2014	The role of the interaction of the vinculin proline-rich linker region with vinexin alpha in sensing the stiffness of the extracellular matrix.	Proline	44-51	vinculin	Homo sapiens	35-43
24554436-0	2014	The role of the interaction of the vinculin proline-rich linker region with vinexin alpha in sensing the stiffness of the extracellular matrix.	Proline	44-51	sorbin and SH3 domain containing 3	Homo sapiens	76-83
24554436-2	2014	In this study, we show that the proline-rich linker (PRL) region of vinculin and the PRL-region-binding protein vinexin are involved in sensing the stiffness of ECM substrates.	Proline	32-39	vinculin	Homo sapiens	68-76
24554436-2	2014	In this study, we show that the proline-rich linker (PRL) region of vinculin and the PRL-region-binding protein vinexin are involved in sensing the stiffness of ECM substrates.	Proline	32-39	sorbin and SH3 domain containing 3	Homo sapiens	112-119
24697566-1	2014	INTRODUCTION: The purpose of this study was to examine whether a Proline (Pro)-to-Alanine (Ala) exchange at codon 12 (Pro12Ala) polymorphism of the peroxisome proliferator-activated receptor-gamma (PPARgamma) is associated with susceptibility to nonalcoholic fatty liver disease (NAFLD), rheumatoid arthritis (RA), and psoriatic arthritis (PsA).	Proline	65-72	peroxisome proliferator activated receptor gamma	Homo sapiens	148-196
24697566-1	2014	INTRODUCTION: The purpose of this study was to examine whether a Proline (Pro)-to-Alanine (Ala) exchange at codon 12 (Pro12Ala) polymorphism of the peroxisome proliferator-activated receptor-gamma (PPARgamma) is associated with susceptibility to nonalcoholic fatty liver disease (NAFLD), rheumatoid arthritis (RA), and psoriatic arthritis (PsA).	Proline	65-72	peroxisome proliferator activated receptor gamma	Homo sapiens	198-207
24697566-1	2014	INTRODUCTION: The purpose of this study was to examine whether a Proline (Pro)-to-Alanine (Ala) exchange at codon 12 (Pro12Ala) polymorphism of the peroxisome proliferator-activated receptor-gamma (PPARgamma) is associated with susceptibility to nonalcoholic fatty liver disease (NAFLD), rheumatoid arthritis (RA), and psoriatic arthritis (PsA).	Proline	65-68	peroxisome proliferator activated receptor gamma	Homo sapiens	148-196
24697566-1	2014	INTRODUCTION: The purpose of this study was to examine whether a Proline (Pro)-to-Alanine (Ala) exchange at codon 12 (Pro12Ala) polymorphism of the peroxisome proliferator-activated receptor-gamma (PPARgamma) is associated with susceptibility to nonalcoholic fatty liver disease (NAFLD), rheumatoid arthritis (RA), and psoriatic arthritis (PsA).	Proline	65-68	peroxisome proliferator activated receptor gamma	Homo sapiens	198-207
24509437-5	2014	Furthermore, a mass spectrometry-based in vitro kinase assay demonstrated that ERK2 specifically phosphorylated the Ser(16) residue in the Ser(16)-Pro(17) motif-containing substrate.	Proline	147-150	mitogen-activated protein kinase 1	Homo sapiens	79-83
24431009-3	2014	We here present evidence that PYCR1 is indeed able to produce L-pipecolic acid from P6C preparations, and the observed K m for this conversion is of the same magnitude as the K m described for the conversion of P5C to L-proline by PYCR1.	Proline	218-227	pyrroline-5-carboxylate reductase 1	Homo sapiens	30-35
24431009-3	2014	We here present evidence that PYCR1 is indeed able to produce L-pipecolic acid from P6C preparations, and the observed K m for this conversion is of the same magnitude as the K m described for the conversion of P5C to L-proline by PYCR1.	Proline	218-227	pyrroline-5-carboxylate reductase 1	Homo sapiens	231-236
24726865-10	2014	In Sm-B/B", one of the putative disordered binding sites (residues 114-165) encompasses the T-cell epitope 136-153, while another, residues 200-216, flanks two proline-rich B-cell epitopes (residues 190-198 and 216-222), overlapping the preferred CD2BP2-GYF-binding motif (R/K/G)XXPPGX(R/K), characteristic of splicosomal proteins.	Proline	160-167	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	3-9
24702481-0	2014	Molecular dynamics of the proline switch and its role in Crk signaling.	Proline	26-33	CRK proto-oncogene, adaptor protein	Gallus gallus	57-60
24702481-4	2014	It is initiated by a cis-trans isomerization of a specific proline residue (Pro238 in chicken Crk II) and can be accelerated by Cyclophilin A.	Proline	59-66	CRK proto-oncogene, adaptor protein	Homo sapiens	94-100
24702481-4	2014	It is initiated by a cis-trans isomerization of a specific proline residue (Pro238 in chicken Crk II) and can be accelerated by Cyclophilin A.	Proline	59-66	peptidylprolyl isomerase A	Gallus gallus	128-141
24702481-5	2014	To understand how the proline switch controls the autoinhibition at the molecular level, we performed large-scale molecular dynamics and metadynamics simulations in the context of short peptides and multidomain constructs of chicken Crk II.	Proline	22-29	CRK proto-oncogene, adaptor protein	Homo sapiens	233-239
24755992-4	2014	In this study, two proline analogues (PA1 and PA2) were screened as PHD3 inhibitors with apparent EC50 values of 1.53 and 3.17 microM respectively, indicating good inhibition potency.	Proline	19-26	PAXIP1 associated glutamate rich protein 1	Homo sapiens	38-41
24467670-1	2014	Delta(1)-pyrroline-5-carboxylate (P5C) reductase (P5CR) catalyses the final step of proline synthesis in plants.	Proline	84-91	pyrroline-5- carboxylate (P5C) reductase	Arabidopsis thaliana	50-54
24467670-10	2014	The biochemical properties of A. thaliana P5CR suggest a complex regulation of enzyme activity by the redox status of the pyridine nucleotide pools, and the concentrations of proline and chloride in the cytosol.	Proline	175-182	pyrroline-5- carboxylate (P5C) reductase	Arabidopsis thaliana	42-46
24467670-11	2014	Data support a to date underestimated role of P5CR in controlling stress-induced proline accumulation.	Proline	81-88	pyrroline-5- carboxylate (P5C) reductase	Arabidopsis thaliana	46-50
24676856-4	2014	Under unstressed conditions, msl2 msl3 seedlings exhibited several hallmarks of drought or environmental osmotic stress, including solute accumulation, elevated levels of the compatible osmolyte proline (Pro), and accumulation of the stress hormone abscisic acid (ABA).	Proline	195-202	MSCS-like 2	Arabidopsis thaliana	29-33
24676856-4	2014	Under unstressed conditions, msl2 msl3 seedlings exhibited several hallmarks of drought or environmental osmotic stress, including solute accumulation, elevated levels of the compatible osmolyte proline (Pro), and accumulation of the stress hormone abscisic acid (ABA).	Proline	195-202	MSCS-like 3	Arabidopsis thaliana	34-38
24676856-6	2014	Pro accumulation in the msl2 msl3 mutant was suppressed by conditions that reduce plastid osmotic stress or inhibition of ABA biosynthesis.	Proline	0-3	MSCS-like 2	Arabidopsis thaliana	24-33
24623412-2	2014	Here, we show that the proline-rich sequences in the hypervariable domain of nonstructural protein 3 (nsP3) of both Semliki Forest virus and Chikungunya virus were dispensable for binding to G3BP.	Proline	23-30	SH2 domain containing 3C	Homo sapiens	102-106
24790206-2	2014	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that regulates a broad range of brain functions through phosphorylation of a myriad of substrates, including tyrosine hydroxylase (TH), the rate-limiting enzyme for dopamine synthesis.	Proline	38-45	cyclin-dependent kinase 5	Mus musculus	0-25
24790206-2	2014	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that regulates a broad range of brain functions through phosphorylation of a myriad of substrates, including tyrosine hydroxylase (TH), the rate-limiting enzyme for dopamine synthesis.	Proline	38-45	cyclin-dependent kinase 5	Mus musculus	27-31
24508896-0	2014	Effect of organic ligands (L-Proline and L-Methionine) on growth, structural, vibrational, crystalline perfection, SHG efficiency, microscopic and optical properties of KDP single crystals.	Proline	27-36	WNK lysine deficient protein kinase 1	Homo sapiens	169-172
24508896-6	2014	Crystalline perfection of KDP crystals with LP and LM doping was examined by high-resolution X-ray diffraction.	Proline	44-46	WNK lysine deficient protein kinase 1	Homo sapiens	26-29
24755992-4	2014	In this study, two proline analogues (PA1 and PA2) were screened as PHD3 inhibitors with apparent EC50 values of 1.53 and 3.17 microM respectively, indicating good inhibition potency.	Proline	19-26	egl-9 family hypoxia inducible factor 3	Homo sapiens	68-72
24755992-8	2014	Herein, for the first time, we systematically studied proline analogue PA1 as a PHD3 inhibitor, which provides innovative evidence for the treatment of HIF-related diseases.	Proline	54-61	PAXIP1 associated glutamate rich protein 1	Homo sapiens	71-74
24755992-8	2014	Herein, for the first time, we systematically studied proline analogue PA1 as a PHD3 inhibitor, which provides innovative evidence for the treatment of HIF-related diseases.	Proline	54-61	egl-9 family hypoxia inducible factor 3	Homo sapiens	80-84
24509844-6	2014	The SdpI-binding site was mapped to a proline-rich sequence of 22 amino acids within the intracellular loop of GlyRbeta.	Proline	38-45	protein kinase C and casein kinase substrate in neurons 1	Rattus norvegicus	4-8
24509844-6	2014	The SdpI-binding site was mapped to a proline-rich sequence of 22 amino acids within the intracellular loop of GlyRbeta.	Proline	38-45	glycine receptor, beta	Rattus norvegicus	111-119
24747353-4	2014	Myosin IB is a monomeric, non-filamentous myosin with a globular head that binds to F-actin and has motor activity, and a non-helical tail comprising a basic region, a glycine-proline-glutamine-rich region and an SH3-domain.	Proline	176-183	myosin IB	Homo sapiens	0-9
24747353-10	2014	We conclude that myosin IB contributes to anchoring actin waves to the plasma membranes by binding of the basic-hydrophobic site to acidic phospholipids in the plasma membrane and binding of the Gly-Pro-Gln region to F-actin in the wave.	Proline	199-202	myosin IB	Homo sapiens	17-26
24706888-0	2014	Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin.	Proline	61-68	filamin C	Homo sapiens	115-122
24639356-2	2014	Our previous work using knockin mice expressing point mutations in CD28 demonstrated that the distal proline motif was primarily responsible for much of CD28 function, whereas in marked contrast to prior studies, mutation of the PI3K-binding motif had little discernible effect.	Proline	101-108	CD28 antigen	Mus musculus	67-71
24706888-2	2014	In this study, we use single-molecule mechanical measurements to develop a full kinetic and energetic description of a highly conserved proline switch in the force-sensing domain 20 of human filamin and how prolyl isomerization modulates the force-sensing mechanism.	Proline	136-143	filamin C	Homo sapiens	191-198
24639356-2	2014	Our previous work using knockin mice expressing point mutations in CD28 demonstrated that the distal proline motif was primarily responsible for much of CD28 function, whereas in marked contrast to prior studies, mutation of the PI3K-binding motif had little discernible effect.	Proline	101-108	CD28 antigen	Mus musculus	153-157
24706892-5	2014	Regulation of NC dimerization is unique to the kinesin-3 family and in the case of KIF13A and KIF13B requires the release of a proline-induced kink between the NC and subsequent coiled-coil 1 segments.	Proline	127-134	kinesin family member 13A	Homo sapiens	83-89
24706892-5	2014	Regulation of NC dimerization is unique to the kinesin-3 family and in the case of KIF13A and KIF13B requires the release of a proline-induced kink between the NC and subsequent coiled-coil 1 segments.	Proline	127-134	kinesin family member 13B	Homo sapiens	94-100
24530433-1	2014	PAT4, the fourth member of the SLC36/proton dependent amino acid transporter (PAT) family, is a high-affinity, low capacity electroneutral transporter of neutral amino acids like proline and tryptophan.	Proline	179-186	solute carrier family 36 (proton/amino acid symporter), member 4	Mus musculus	0-4
24611845-4	2014	Structural analysis indicated that Grx8 possesses a negatively charged CXXC motif (Cys(33)-Pro(34)-Asp(35)-Cys(36)) and a GSH-recognition site, which are distinct from Grx1 and Grx2.	Proline	91-94	glutathione-disulfide reductase GRX8	Saccharomyces cerevisiae S288C	35-39
24380763-8	2014	Combining the proline mutations with rationally designed mutants from a previous study led to 2400-fold increase in the affinity of the A6 T-cell receptor for Tax-HLAA2.	Proline	14-21	contactin 2	Homo sapiens	159-168
24613846-8	2014	Besides, proline-rich (Pro) region and CARD domain of MAVS are indispensable for the process of eEF1Bgamma mediated ubiquitination.	Proline	9-16	mitochondrial antiviral signaling protein	Homo sapiens	54-58
24613846-8	2014	Besides, proline-rich (Pro) region and CARD domain of MAVS are indispensable for the process of eEF1Bgamma mediated ubiquitination.	Proline	9-16	eukaryotic translation elongation factor 1 gamma	Homo sapiens	96-106
24063596-11	2014	Increased MHC (myosin heavy chain) expression and [3H]-proline incorporation in cardiomyocytes was detected after cyclic stretch, which were inhibited by leptin siRNA and NAC.	Proline	55-62	leptin	Rattus norvegicus	154-160
24705540-3	2014	Typical SSB proteins have an N-terminal Oligonucleotide-Binding (OB) fold, a Proline/Glycine rich region, followed by a C-terminal acidic tail.	Proline	77-84	single-stranded DNA-binding protein	Escherichia coli	8-11
24440360-2	2014	Two point mutations together in the proline rich region (PRR) domain of WASP (S339Y/P373S) have been reported to cause WAS however the molecular defect has not been characterized.	Proline	36-43	WASP actin nucleation promoting factor	Homo sapiens	72-76
24407176-5	2014	A proline-rich region in the N-terminus of INSM1 is required for RACK1 binding, which interrupts RACK1-InR interaction and enhances InR signal activation.	Proline	2-9	INSM transcriptional repressor 1	Rattus norvegicus	43-48
24407176-5	2014	A proline-rich region in the N-terminus of INSM1 is required for RACK1 binding, which interrupts RACK1-InR interaction and enhances InR signal activation.	Proline	2-9	receptor for activated C kinase 1	Rattus norvegicus	65-70
24407176-5	2014	A proline-rich region in the N-terminus of INSM1 is required for RACK1 binding, which interrupts RACK1-InR interaction and enhances InR signal activation.	Proline	2-9	receptor for activated C kinase 1	Rattus norvegicus	97-102
24407176-5	2014	A proline-rich region in the N-terminus of INSM1 is required for RACK1 binding, which interrupts RACK1-InR interaction and enhances InR signal activation.	Proline	2-9	insulin receptor	Rattus norvegicus	103-106
24407176-5	2014	A proline-rich region in the N-terminus of INSM1 is required for RACK1 binding, which interrupts RACK1-InR interaction and enhances InR signal activation.	Proline	2-9	insulin receptor	Rattus norvegicus	132-135
24210052-7	2014	A novel metabolism of proline and arginine catalyzed by N-acetyltransferase Mpr1 in the mitochondria eventually leads to synthesis of nitric oxide, which confers oxidative stress tolerance on yeast cells.	Proline	22-29	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	76-80
24462457-4	2014	Myo1e localization to the actin-rich core of invadosomes required the proline-rich Tail Homology 2 (TH2) domain.	Proline	70-77	unconventional myosin-Ie	Mesocricetus auratus	0-5
24525351-8	2014	Furthermore, ubiquitin E3 ligase activity and genetic data indicate that AtRZF1 and LsRZF1 function in similar pathway to control proline metabolism in Arabidopsis under drought condition.	Proline	130-137	RING/U-box superfamily protein	Arabidopsis thaliana	73-79
24037986-3	2014	Pin1 is a unique substrate-specific enzyme that can isomerize phospho-Ser/Thr-Pro peptide bonds, accelerating the conformational change in its substrates between a cis and a trans form.	Proline	78-81	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
24478452-3	2014	Most EB1-binding proteins contain a Ser-any residue-Ile-Pro (SxIP) motif.	Proline	56-59	Eb1	Drosophila melanogaster	5-8
24556574-1	2014	In the Src Homology 3 domain (SH3) the RT and n-Src loops form a pocket that accounts for the specificity and affinity in binding of proline rich motifs (PRMs), while the distal and diverging turns play a key role in the folding of the protein.	Proline	133-140	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	7-10
24556574-1	2014	In the Src Homology 3 domain (SH3) the RT and n-Src loops form a pocket that accounts for the specificity and affinity in binding of proline rich motifs (PRMs), while the distal and diverging turns play a key role in the folding of the protein.	Proline	133-140	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	48-51
24584464-2	2014	IRSp53 contains a membrane-binding BAR domain followed by an unconventional CRIB motif that overlaps with a proline-rich region (CRIB-PR) and an SH3 domain that recruits actin cytoskeleton effectors.	Proline	108-115	BAR/IMD domain containing adaptor protein 2	Homo sapiens	0-6
24287716-8	2014	Analysis of substrate specificity showed that AtCEP2 accepts proline near the cleavage site, which is a rare feature specific for KDEL-CysEPs.	Proline	61-68	Cysteine proteinases superfamily protein	Arabidopsis thaliana	46-52
24561249-3	2014	Overexpression of AtWNK9 from the cauliflower mosaic virus 35S promoter in Arabidopsis resulted in increased sensitivity to ABA, strong inhibition of primary root elongation, increased proline accumulation, reduced stomatal aperture, and a reduced rate of water loss.	Proline	185-192	Protein kinase superfamily protein	Arabidopsis thaliana	18-24
24589734-3	2014	Previously, we characterized mechanisms underlying JNK phosphorylation of STMN at proline-flanked serine residues (Ser25 and Ser38) that are conserved across STMN-like proteins.	Proline	82-89	mitogen-activated protein kinase 8	Homo sapiens	51-54
24085488-8	2014	We show by in silico exchange mutations in the S3 pocket of the proteases that a proline residue in Caspase 7 contributes to the narrowed conformational space of the binding site.	Proline	81-88	caspase 7	Homo sapiens	100-109
24150971-7	2014	The simulation data also predicted that proline content contributed minimally to the native Rh of p53(1-93), which was confirmed by measuring Rh for a substitution variant that had all 22 proline residues changed for glycine.	Proline	40-47	tumor protein p53	Homo sapiens	98-101
24326769-0	2014	The association between polymorphism of P53 Codon72 Arg/Pro and hepatocellular carcinoma susceptibility: evidence from a meta-analysis of 15 studies with 3,704 cases.	Proline	56-59	tumor protein p53	Homo sapiens	40-43
24326769-2	2014	Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.	Proline	48-55	tumor protein p53	Homo sapiens	16-19
24326769-2	2014	Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.	Proline	48-55	tumor protein p53	Homo sapiens	104-107
24326769-2	2014	Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.	Proline	57-60	tumor protein p53	Homo sapiens	16-19
24326769-2	2014	Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.	Proline	57-60	tumor protein p53	Homo sapiens	104-107
24326769-3	2014	It has been suggested that p53 codon72 Arg/Pro polymorphism is associated with susceptibility to hepatocellular carcinoma (HCC).	Proline	43-46	tumor protein p53	Homo sapiens	27-30
24326769-10	2014	This meta-analysis suggests that p53 codon72 Arg/Pro polymorphism may be associated with the risk of HCC, especially in subgroup analysis of Asian and Caucasian population, hospital-based population, the female, and the individuals infected with hepatitis virus.	Proline	49-52	tumor protein p53	Homo sapiens	33-36
24656827-6	2014	Binding between CNK2 and Vilse was found to be constitutive, mediated by the WW domains of Vilse and a proline motif in CNK2.	Proline	103-110	connector enhancer of kinase suppressor of Ras 2	Homo sapiens	16-20
24656827-6	2014	Binding between CNK2 and Vilse was found to be constitutive, mediated by the WW domains of Vilse and a proline motif in CNK2.	Proline	103-110	Rho GTPase activating protein 39	Homo sapiens	25-30
24656827-6	2014	Binding between CNK2 and Vilse was found to be constitutive, mediated by the WW domains of Vilse and a proline motif in CNK2.	Proline	103-110	connector enhancer of kinase suppressor of Ras 2	Homo sapiens	120-124
24099035-1	2014	The proline-specific dipeptidyl aminopeptidase IV (DPP IV, DPP-4, CD26), widely expressed in mammalians, releases X-Pro/Ala dipeptides from the N-terminus of peptides.	Proline	4-11	dipeptidyl peptidase 4	Homo sapiens	51-57
24099035-1	2014	The proline-specific dipeptidyl aminopeptidase IV (DPP IV, DPP-4, CD26), widely expressed in mammalians, releases X-Pro/Ala dipeptides from the N-terminus of peptides.	Proline	4-11	dipeptidyl peptidase 4	Homo sapiens	59-64
24099035-1	2014	The proline-specific dipeptidyl aminopeptidase IV (DPP IV, DPP-4, CD26), widely expressed in mammalians, releases X-Pro/Ala dipeptides from the N-terminus of peptides.	Proline	4-11	dipeptidyl peptidase 4	Homo sapiens	66-70
24589734-3	2014	Previously, we characterized mechanisms underlying JNK phosphorylation of STMN at proline-flanked serine residues (Ser25 and Ser38) that are conserved across STMN-like proteins.	Proline	82-89	stathmin 1	Homo sapiens	74-78
24589734-3	2014	Previously, we characterized mechanisms underlying JNK phosphorylation of STMN at proline-flanked serine residues (Ser25 and Ser38) that are conserved across STMN-like proteins.	Proline	82-89	stathmin 1	Homo sapiens	158-162
24662752-10	2014	Sox6 was detected by phospho-Ser/Thr and phospho-Ser/Thr-Pro and MPM-2 (Mitotic protein #2) antibodies in brain.	Proline	57-60	SRY (sex determining region Y)-box 6	Mus musculus	0-4
24658276-2	2014	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly active in the nervous system.	Proline	38-45	cyclin-dependent kinase 5	Mus musculus	0-25
24658276-2	2014	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly active in the nervous system.	Proline	38-45	cyclin-dependent kinase 5	Mus musculus	27-31
24642411-4	2014	In contrast, Wnt/beta-catenin signal transduction requires phosphorylation of Ser/Pro rich sequences present in the Wnt co-receptors LRP5/6, and these motifs inhibit GSK-3 activity.	Proline	82-85	catenin beta 1	Homo sapiens	17-29
24506136-1	2014	In the social amoeba Dictyostelium, Skp1 is hydroxylated on proline 143 and further modified by three cytosolic glycosyltransferases to yield an O-linked pentasaccharide that contributes to O2 regulation of development.	Proline	60-67	S-phase kinase associated protein 1	Homo sapiens	36-40
24550462-2	2014	Using mass spectrometric analyses of Saccharomyces cerevisiae ribosomes, we found that the amino acid residue in closest proximity to the decoding center, Pro-64 of the 40S subunit ribosomal protein Rps23p (RPS23 Pro-62 in humans) undergoes posttranslational hydroxylation.	Proline	155-158	ribosomal protein S23	Homo sapiens	207-212
24550462-2	2014	Using mass spectrometric analyses of Saccharomyces cerevisiae ribosomes, we found that the amino acid residue in closest proximity to the decoding center, Pro-64 of the 40S subunit ribosomal protein Rps23p (RPS23 Pro-62 in humans) undergoes posttranslational hydroxylation.	Proline	213-216	ribosomal protein S23	Homo sapiens	207-212
24642411-4	2014	In contrast, Wnt/beta-catenin signal transduction requires phosphorylation of Ser/Pro rich sequences present in the Wnt co-receptors LRP5/6, and these motifs inhibit GSK-3 activity.	Proline	82-85	LDL receptor related protein 5	Homo sapiens	133-139
23542169-7	2014	In addition, RUNX3 directly interacted with the C-terminal activation domain of HIF-1alpha and prolyl hydroxylase (PHD) 2 and enhanced the interaction between HIF-1alpha and PHD2, which potentiated proline hydroxylation and promoted the degradation of HIF-1alpha.	Proline	198-205	RUNX family transcription factor 3	Homo sapiens	13-18
24637538-1	2014	Cyclin-dependent kinase 5 (Cdk5)-p35 is a proline-directed Ser/Thr kinase which plays a key role in neuronal migration, neurite outgrowth, and spine formation during brain development.	Proline	42-49	cyclin-dependent kinase 5	Mus musculus	0-25
24637538-1	2014	Cyclin-dependent kinase 5 (Cdk5)-p35 is a proline-directed Ser/Thr kinase which plays a key role in neuronal migration, neurite outgrowth, and spine formation during brain development.	Proline	42-49	cyclin-dependent kinase 5	Mus musculus	27-31
24637538-1	2014	Cyclin-dependent kinase 5 (Cdk5)-p35 is a proline-directed Ser/Thr kinase which plays a key role in neuronal migration, neurite outgrowth, and spine formation during brain development.	Proline	42-49	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	33-36
24424024-3	2014	Yeast mutants lacking TSA1 are sensitive to misfolding caused by exposure to the proline analogue azetidine-2-carboxylic acid (AZC).	Proline	81-88	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	22-26
23542169-7	2014	In addition, RUNX3 directly interacted with the C-terminal activation domain of HIF-1alpha and prolyl hydroxylase (PHD) 2 and enhanced the interaction between HIF-1alpha and PHD2, which potentiated proline hydroxylation and promoted the degradation of HIF-1alpha.	Proline	198-205	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
23542169-7	2014	In addition, RUNX3 directly interacted with the C-terminal activation domain of HIF-1alpha and prolyl hydroxylase (PHD) 2 and enhanced the interaction between HIF-1alpha and PHD2, which potentiated proline hydroxylation and promoted the degradation of HIF-1alpha.	Proline	198-205	hypoxia inducible factor 1 subunit alpha	Homo sapiens	159-169
23542169-7	2014	In addition, RUNX3 directly interacted with the C-terminal activation domain of HIF-1alpha and prolyl hydroxylase (PHD) 2 and enhanced the interaction between HIF-1alpha and PHD2, which potentiated proline hydroxylation and promoted the degradation of HIF-1alpha.	Proline	198-205	egl-9 family hypoxia inducible factor 1	Homo sapiens	174-178
23542169-7	2014	In addition, RUNX3 directly interacted with the C-terminal activation domain of HIF-1alpha and prolyl hydroxylase (PHD) 2 and enhanced the interaction between HIF-1alpha and PHD2, which potentiated proline hydroxylation and promoted the degradation of HIF-1alpha.	Proline	198-205	hypoxia inducible factor 1 subunit alpha	Homo sapiens	159-169
23542169-9	2014	Taken together, these results suggest that RUNX3 destabilizes HIF-1alpha protein by promoting the proline hydroxylation of HIF-1alpha through binding to HIF-1alpha/PHD2.	Proline	98-105	RUNX family transcription factor 3	Homo sapiens	43-48
23542169-9	2014	Taken together, these results suggest that RUNX3 destabilizes HIF-1alpha protein by promoting the proline hydroxylation of HIF-1alpha through binding to HIF-1alpha/PHD2.	Proline	98-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-72
24559475-4	2014	A series of peptides derived from the proline-rich domain (residues 174-251) of tau was synthesized, with free Ser/Thr hydroxyls, phosphorylated Ser/Thr (pSer/pThr), OGlcNAcylated Ser/Thr, and diethylphosphorylated Ser/Thr.	Proline	38-45	microtubule associated protein tau	Homo sapiens	80-83
23542169-9	2014	Taken together, these results suggest that RUNX3 destabilizes HIF-1alpha protein by promoting the proline hydroxylation of HIF-1alpha through binding to HIF-1alpha/PHD2.	Proline	98-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-133
23542169-9	2014	Taken together, these results suggest that RUNX3 destabilizes HIF-1alpha protein by promoting the proline hydroxylation of HIF-1alpha through binding to HIF-1alpha/PHD2.	Proline	98-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-133
23542169-9	2014	Taken together, these results suggest that RUNX3 destabilizes HIF-1alpha protein by promoting the proline hydroxylation of HIF-1alpha through binding to HIF-1alpha/PHD2.	Proline	98-105	egl-9 family hypoxia inducible factor 1	Homo sapiens	164-168
23474762-6	2014	We found that, in an Rb(+/-) background promoting pituitary and thyroid tumors, decreased Mdm4 levels improved the survival of mice expressing wild-type p53, but not that of mice expressing p53(DeltaP), a p53 hypomorph lacking the proline-rich domain.	Proline	231-238	transformed mouse 3T3 cell double minute 4	Mus musculus	90-94
24412394-0	2014	Autoinhibitory structure of the WW domain of HYPB/SETD2 regulates its interaction with the proline-rich region of huntingtin.	Proline	91-98	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	45-49
24502590-1	2014	The proline catabolic enzyme Delta(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1) catalyzes the NAD(+)-dependent oxidation of gamma-glutamate semialdehyde to l-glutamate.	Proline	4-11	aldehyde dehydrogenase 4 family member A1	Homo sapiens	77-84
24606930-0	2014	Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.	Proline	0-7	potassium voltage-gated channel subfamily H member 2	Homo sapiens	20-24
24606930-2	2014	Human ether-a-go-go-related gene (hERG) channels lack the proline-valine-proline motif and the location of the intracellular pore gate and how it is coupled to S4 movement is less clear.	Proline	58-65	ETS transcription factor ERG	Homo sapiens	34-38
24412394-0	2014	Autoinhibitory structure of the WW domain of HYPB/SETD2 regulates its interaction with the proline-rich region of huntingtin.	Proline	91-98	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	50-55
24606930-2	2014	Human ether-a-go-go-related gene (hERG) channels lack the proline-valine-proline motif and the location of the intracellular pore gate and how it is coupled to S4 movement is less clear.	Proline	73-80	ETS transcription factor ERG	Homo sapiens	34-38
24606930-3	2014	Here, we show that proline substitutions within the S6 of hERG perturbed pore gate closure, trapping channels in the open state.	Proline	19-26	ETS transcription factor ERG	Homo sapiens	58-62
24412394-0	2014	Autoinhibitory structure of the WW domain of HYPB/SETD2 regulates its interaction with the proline-rich region of huntingtin.	Proline	91-98	huntingtin	Homo sapiens	114-124
24606930-4	2014	Performing a proline scan of the inner S6 helix, from Ile(655) to Tyr(667) revealed that gate perturbation occurred with proximal (I655P-Q664P), but not distal (R665P-Y667P) substitutions, suggesting that Gln(664) marks the position of the intracellular gate in hERG channels.	Proline	13-20	ETS transcription factor ERG	Homo sapiens	262-266
24412394-5	2014	This autoinhibitory structure regulates interaction between the WW domain of HYPB and the proline-rich region (PRR) of Htt, as evidenced by NMR and immunofluorescence techniques.	Proline	90-97	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	77-81
24412394-5	2014	This autoinhibitory structure regulates interaction between the WW domain of HYPB and the proline-rich region (PRR) of Htt, as evidenced by NMR and immunofluorescence techniques.	Proline	90-97	huntingtin	Homo sapiens	119-122
24215395-7	2014	RESULTS: Two previously reported missense variations C &gt; T, rs4468717 (first base of codon 143) changing proline to serine and rs2229333 (second base of codon 143) changing proline to leucine were identified in exon 10 of TGIF1.	Proline	108-115	TGFB induced factor homeobox 1	Homo sapiens	225-230
24215395-7	2014	RESULTS: Two previously reported missense variations C &gt; T, rs4468717 (first base of codon 143) changing proline to serine and rs2229333 (second base of codon 143) changing proline to leucine were identified in exon 10 of TGIF1.	Proline	176-183	TGFB induced factor homeobox 1	Homo sapiens	225-230
24480037-0	2014	Serine and proline-rich ligands enriched via phage-display technology show preferential binding to BCR/ABL expressing cells.	Proline	11-18	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	99-106
24480037-7	2014	These peptides contained either multiple proline residues or serine/threonine-proline pairs and showed a confirmed binding preference for BCR/ABL+ fibroblasts.	Proline	78-85	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	138-145
24470497-1	2014	On TCR ligation, the adaptor Nck is recruited through its src homology 3.1 domain to a proline-rich sequence (PRS) in CD3epsilon.	Proline	87-94	T cell receptor alpha variable 6-3	Mus musculus	3-6
24470497-1	2014	On TCR ligation, the adaptor Nck is recruited through its src homology 3.1 domain to a proline-rich sequence (PRS) in CD3epsilon.	Proline	87-94	non-catalytic region of tyrosine kinase adaptor protein 1	Mus musculus	29-32
24470497-1	2014	On TCR ligation, the adaptor Nck is recruited through its src homology 3.1 domain to a proline-rich sequence (PRS) in CD3epsilon.	Proline	87-94	CD3 antigen, epsilon polypeptide	Mus musculus	118-128
24201779-7	2014	RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]).	Proline	55-62	neuropeptide Y	Homo sapiens	98-112
24366026-2	2014	The polymorphism in the p53 72nd codon involves a proline to arginine substitution, leading to changes in gene transcription activity, interaction with other proteins and modulation of apoptosis.	Proline	50-57	tumor protein p53	Homo sapiens	24-27
24201779-7	2014	RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]).	Proline	55-62	neuropeptide Y	Homo sapiens	114-117
24201779-7	2014	RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]).	Proline	66-73	neuropeptide Y	Homo sapiens	98-112
24201779-7	2014	RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]).	Proline	66-73	neuropeptide Y	Homo sapiens	114-117
24201779-7	2014	RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]).	Proline	66-73	neuropeptide Y	Homo sapiens	98-112
24201779-7	2014	RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]).	Proline	66-73	neuropeptide Y	Homo sapiens	114-117
24225368-5	2014	In the case of a single basic residue, there is no cleavage if proline residues are present in the P1 and P2 positions.	Proline	63-70	replication initiation protein	Escherichia coli	99-108
24333369-0	2014	Production and characterization of a retinoic acid receptor RARgamma construction encompassing the DNA binding domain and the disordered N-terminal proline rich domain.	Proline	148-155	retinoic acid receptor gamma	Homo sapiens	60-68
24333369-2	2014	Among the several phosphorylation sites that are involved in the non-genomic regulatory pathways of the RAR, two are located in a proline rich domain (PRD) within the N-terminal domain (NTD) of the receptor.	Proline	130-137	retinoic acid receptor alpha	Homo sapiens	104-107
23503467-7	2014	We identify Ser(118) as the major PKD2 phosphorylation site in CIB1a and show that PKD2 interacts with CIB1a via its alanine and proline-rich domain.	Proline	129-136	protein kinase D2	Homo sapiens	83-87
24586906-0	2014	Disruption of Fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinase.	Proline	48-55	Fyn proto-oncogene	Mus musculus	14-17
24586906-0	2014	Disruption of Fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinase.	Proline	48-55	serine/threonine kinase 11	Mus musculus	70-85
24701227-1	2014	INTRODUCTIONS: Phospho-PRAS40(Thr246) (phosphorylated proline-rich Akt substrate of 40 kilodaltons at Thr246) is a biomarker for phosphatidylinositol 3-kinase (PI3K) pathway activation and AKT inhibitors sensitivity.	Proline	54-61	AKT1 substrate 1	Homo sapiens	23-29
24586906-4	2014	Effects of point mutations in the Fyn SH2/SH3 domains and in the LKB1 proline-rich motif on 1) Fyn and LKB1 binding, 2) LKB1 subcellular localization and 3) AMPK phosphorylation were investigated in C2C12 muscle cells.	Proline	70-77	serine/threonine kinase 11	Mus musculus	65-69
24586906-4	2014	Effects of point mutations in the Fyn SH2/SH3 domains and in the LKB1 proline-rich motif on 1) Fyn and LKB1 binding, 2) LKB1 subcellular localization and 3) AMPK phosphorylation were investigated in C2C12 muscle cells.	Proline	70-77	Fyn proto-oncogene	Mus musculus	95-98
24586906-4	2014	Effects of point mutations in the Fyn SH2/SH3 domains and in the LKB1 proline-rich motif on 1) Fyn and LKB1 binding, 2) LKB1 subcellular localization and 3) AMPK phosphorylation were investigated in C2C12 muscle cells.	Proline	70-77	serine/threonine kinase 11	Mus musculus	103-107
24586906-4	2014	Effects of point mutations in the Fyn SH2/SH3 domains and in the LKB1 proline-rich motif on 1) Fyn and LKB1 binding, 2) LKB1 subcellular localization and 3) AMPK phosphorylation were investigated in C2C12 muscle cells.	Proline	70-77	serine/threonine kinase 11	Mus musculus	103-107
24586906-5	2014	Additionally, novel LKB1 proline-rich motif mimicking cell permeable peptides were generated to disrupt Fyn/LKB1 binding and investigate the consequences on AMPK activity in both C2C12 cells and mouse skeletal muscle.	Proline	25-32	serine/threonine kinase 11	Mus musculus	20-24
24586906-5	2014	Additionally, novel LKB1 proline-rich motif mimicking cell permeable peptides were generated to disrupt Fyn/LKB1 binding and investigate the consequences on AMPK activity in both C2C12 cells and mouse skeletal muscle.	Proline	25-32	Fyn proto-oncogene	Mus musculus	104-107
24586906-6	2014	Mutation of either Fyn SH3 domain or the proline-rich motif of LKB1 resulted in the disruption of Fyn/LKB1 binding, re-localization of 70% of LKB1 signal in the cytoplasm and a 2-fold increase in AMPK phosphorylation.	Proline	41-48	serine/threonine kinase 11	Mus musculus	63-67
24586906-6	2014	Mutation of either Fyn SH3 domain or the proline-rich motif of LKB1 resulted in the disruption of Fyn/LKB1 binding, re-localization of 70% of LKB1 signal in the cytoplasm and a 2-fold increase in AMPK phosphorylation.	Proline	41-48	Fyn proto-oncogene	Mus musculus	98-101
24586906-6	2014	Mutation of either Fyn SH3 domain or the proline-rich motif of LKB1 resulted in the disruption of Fyn/LKB1 binding, re-localization of 70% of LKB1 signal in the cytoplasm and a 2-fold increase in AMPK phosphorylation.	Proline	41-48	serine/threonine kinase 11	Mus musculus	102-106
24586906-6	2014	Mutation of either Fyn SH3 domain or the proline-rich motif of LKB1 resulted in the disruption of Fyn/LKB1 binding, re-localization of 70% of LKB1 signal in the cytoplasm and a 2-fold increase in AMPK phosphorylation.	Proline	41-48	serine/threonine kinase 11	Mus musculus	102-106
24586906-7	2014	In vivo disruption of the Fyn/LKB1 interaction using LKB1 proline-rich motif mimicking cell permeable peptides recapitulated Fyn pharmacological inhibition.	Proline	58-65	Fyn proto-oncogene	Mus musculus	26-29
24586906-7	2014	In vivo disruption of the Fyn/LKB1 interaction using LKB1 proline-rich motif mimicking cell permeable peptides recapitulated Fyn pharmacological inhibition.	Proline	58-65	serine/threonine kinase 11	Mus musculus	30-34
24586906-7	2014	In vivo disruption of the Fyn/LKB1 interaction using LKB1 proline-rich motif mimicking cell permeable peptides recapitulated Fyn pharmacological inhibition.	Proline	58-65	serine/threonine kinase 11	Mus musculus	53-57
24586906-7	2014	In vivo disruption of the Fyn/LKB1 interaction using LKB1 proline-rich motif mimicking cell permeable peptides recapitulated Fyn pharmacological inhibition.	Proline	58-65	Fyn proto-oncogene	Mus musculus	125-128
24533082-9	2014	Phosphorylation of mTOR(Ser2448) 2 h after exercise was higher with PRO compared to ALC-PRO and ALC-CHO (P&lt;0.05), while p70S6K phosphorylation was higher 2 h post-exercise with ALC-PRO and PRO compared to ALC-CHO (P&lt;0.05).	Proline	68-71	mechanistic target of rapamycin kinase	Homo sapiens	19-23
24586430-6	2014	Insertion of proline linkers between NPC2 and crmCherry had little effect while Gly-Ser linkers promoted cleavage.	Proline	13-20	NPC intracellular cholesterol transporter 2	Homo sapiens	37-41
24586531-3	2014	Themis contains two functionally uncharacterized regions called CABIT (cysteine-containing, all-beta in Themis) domains, a nuclear localization signal (NLS), and a proline-rich sequence (PRS).	Proline	164-171	thymocyte selection associated	Mus musculus	0-6
24563687-0	2014	Proline-hydroxylated hypoxia-inducible factor 1alpha (HIF-1alpha) upregulation in human tumours.	Proline	0-7	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-52
24563687-0	2014	Proline-hydroxylated hypoxia-inducible factor 1alpha (HIF-1alpha) upregulation in human tumours.	Proline	0-7	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-64
24616563-7	2014	Human DHFR domain contains PEKN sequence near active site, though proline is common for all the selected organisms but the other sequences are different in plants.	Proline	66-73	dihydrofolate reductase	Homo sapiens	6-10
24385538-5	2014	The actin-binding and proline-binding activities of pfn1 are required for its function in HSCs.	Proline	22-29	profilin 1	Mus musculus	52-56
24523552-7	2014	Surprisingly, optic nerve injury stimulated the expression of Socs3 and Sfpq (splicing factor, proline/glutamine rich) that attenuate optic nerve regeneration.	Proline	95-102	suppressor of cytokine signaling 3a	Danio rerio	62-67
24563687-2	2014	HIF-alpha is degraded under normoxic conditions by proline hydroxylation, which allows for recognition and ubiquitination by the von-Hippel-Lindau (VHL) E3 ligase complex.	Proline	51-58	von Hippel-Lindau tumor suppressor	Homo sapiens	129-146
24563687-2	2014	HIF-alpha is degraded under normoxic conditions by proline hydroxylation, which allows for recognition and ubiquitination by the von-Hippel-Lindau (VHL) E3 ligase complex.	Proline	51-58	von Hippel-Lindau tumor suppressor	Homo sapiens	148-151
24563687-4	2014	To this end we optimised antibodies against the proline-hydroxylated forms of HIF-1alpha for use in formalin fixed paraffin embedded (FFPE) immunohistochemistry to assess effects in tumour cells in vivo.	Proline	48-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88
24563687-5	2014	We found that HIF-1alpha proline-hydroxylated at both VHL binding sites (Pro402 and Pro564), was present in hypoxic regions of a wide range of tumours, tumour xenografts and in moderately hypoxic cells in vitro.	Proline	25-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24
24563687-5	2014	We found that HIF-1alpha proline-hydroxylated at both VHL binding sites (Pro402 and Pro564), was present in hypoxic regions of a wide range of tumours, tumour xenografts and in moderately hypoxic cells in vitro.	Proline	25-32	von Hippel-Lindau tumor suppressor	Homo sapiens	54-57
24563687-8	2014	Our conclusions are that the degradation of proline-hydroxylated HIF-1alpha may be rate-limited in tumours and therefore provides new insights into mechanisms of HIF upregulation.	Proline	44-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-75
24523552-7	2014	Surprisingly, optic nerve injury stimulated the expression of Socs3 and Sfpq (splicing factor, proline/glutamine rich) that attenuate optic nerve regeneration.	Proline	95-102	splicing factor proline/glutamine-rich	Danio rerio	72-76
24533082-9	2014	Phosphorylation of mTOR(Ser2448) 2 h after exercise was higher with PRO compared to ALC-PRO and ALC-CHO (P&lt;0.05), while p70S6K phosphorylation was higher 2 h post-exercise with ALC-PRO and PRO compared to ALC-CHO (P&lt;0.05).	Proline	88-91	mechanistic target of rapamycin kinase	Homo sapiens	19-23
24563687-9	2014	Persistence of proline-hydroxylated HIF-1alpha in perinecrotic areas suggests there is adequate oxygen to support prolyl hydroxylase domain (PHD) activity and proline-hydroxylated HIF-1alpha may be the predominant form associated with the poorer prognosis that higher levels of HIF-1alpha confer.	Proline	15-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-46
24563687-9	2014	Persistence of proline-hydroxylated HIF-1alpha in perinecrotic areas suggests there is adequate oxygen to support prolyl hydroxylase domain (PHD) activity and proline-hydroxylated HIF-1alpha may be the predominant form associated with the poorer prognosis that higher levels of HIF-1alpha confer.	Proline	159-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	180-190
24533082-9	2014	Phosphorylation of mTOR(Ser2448) 2 h after exercise was higher with PRO compared to ALC-PRO and ALC-CHO (P&lt;0.05), while p70S6K phosphorylation was higher 2 h post-exercise with ALC-PRO and PRO compared to ALC-CHO (P&lt;0.05).	Proline	88-91	allantoicase	Homo sapiens	84-87
24563687-9	2014	Persistence of proline-hydroxylated HIF-1alpha in perinecrotic areas suggests there is adequate oxygen to support prolyl hydroxylase domain (PHD) activity and proline-hydroxylated HIF-1alpha may be the predominant form associated with the poorer prognosis that higher levels of HIF-1alpha confer.	Proline	159-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	180-190
24408985-9	2014	Tear levels of prolactin-induced protein (0.09 +- 0.06 mug/muL) and proline-rich 4 (0.80 +- 0.50 mug/muL) are reported here for the first time.	Proline	68-75	tripartite motif containing 37	Homo sapiens	101-104
24596454-4	2014	PURPOSE: We focused on the cis/trans configurations of the peptide bonds in proline-containing tripeptides in order to discover whether the different structural properties of these peptides influence their activity in ACE-1 inhibition.	Proline	76-83	angiotensin I converting enzyme	Homo sapiens	218-223
24596454-9	2014	Based on molecular docking studies, we propose that in ACE-1 inhibition IPP and VPP share a similar cis configuration between the first aliphatic (isoleucine or valine) and the second (proline) amino acid residues and more different configurations between two proline residues.	Proline	185-192	angiotensin I converting enzyme	Homo sapiens	55-60
24596454-9	2014	Based on molecular docking studies, we propose that in ACE-1 inhibition IPP and VPP share a similar cis configuration between the first aliphatic (isoleucine or valine) and the second (proline) amino acid residues and more different configurations between two proline residues.	Proline	260-267	angiotensin I converting enzyme	Homo sapiens	55-60
24440036-3	2014	Here we show that Caenorhabditis elegans lifespan is regulated by their adaptive capacity to different diets, which is controlled by alh-6, a conserved proline metabolism gene.	Proline	152-159	Aldedh domain-containing protein;L-glutamate gamma-semialdehyde dehydrogenase	Caenorhabditis elegans	133-138
24306101-1	2014	Herein, we report a special case of pseudo-beta-hairpin formation by tetrapetide sequences featuring a two-membered Ant-Pro dipeptide motif (Ant = anthranilic acid and Pro = proline) at the loop region.	Proline	120-123	solute carrier family 25 member 6	Homo sapiens	116-119
24306101-1	2014	Herein, we report a special case of pseudo-beta-hairpin formation by tetrapetide sequences featuring a two-membered Ant-Pro dipeptide motif (Ant = anthranilic acid and Pro = proline) at the loop region.	Proline	120-123	solute carrier family 25 member 6	Homo sapiens	141-144
24306101-1	2014	Herein, we report a special case of pseudo-beta-hairpin formation by tetrapetide sequences featuring a two-membered Ant-Pro dipeptide motif (Ant = anthranilic acid and Pro = proline) at the loop region.	Proline	174-181	solute carrier family 25 member 6	Homo sapiens	116-119
24306101-1	2014	Herein, we report a special case of pseudo-beta-hairpin formation by tetrapetide sequences featuring a two-membered Ant-Pro dipeptide motif (Ant = anthranilic acid and Pro = proline) at the loop region.	Proline	174-181	solute carrier family 25 member 6	Homo sapiens	141-144
24390408-4	2014	The alkylated peptides obtained after enzymatic hydrolysis of human SA modified with the different PAHDE were principally PAHDE-His-Pro, PAHDE-His-Pro-Tyr and PAHDE-Lys.	Proline	132-135	albumin	Homo sapiens	68-70
24334254-8	2014	This is clearly illustrated by the differences in copy numbers not only in gene PUT1, the main player in the assimilation of proline as a nitrogen source, but also in CAR2, involved in arginine catabolism.	Proline	125-132	proline dehydrogenase	Saccharomyces cerevisiae S288C	80-84
24334254-8	2014	This is clearly illustrated by the differences in copy numbers not only in gene PUT1, the main player in the assimilation of proline as a nitrogen source, but also in CAR2, involved in arginine catabolism.	Proline	125-132	ornithine-oxo-acid transaminase	Saccharomyces cerevisiae S288C	167-171
24334254-9	2014	Strains isolated from fermentations where proline is more abundant contain a higher number of PUT1 copies and are more efficient in assimilating this amino acid as a nitrogen source.	Proline	42-49	proline dehydrogenase	Saccharomyces cerevisiae S288C	94-98
24390408-4	2014	The alkylated peptides obtained after enzymatic hydrolysis of human SA modified with the different PAHDE were principally PAHDE-His-Pro, PAHDE-His-Pro-Tyr and PAHDE-Lys.	Proline	147-150	albumin	Homo sapiens	68-70
24534472-1	2014	Pin1 is a unique enzyme that changes the shape of target proteins by acting on specific amino acids that have been phosphorylated: serine or threonine residues that precede proline.	Proline	173-180	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
24369382-4	2014	We demonstrate that proline 47 is a key amino acid essential for maintaining the WWOX protein fully functional, with its mutation into a threonine resulting in a loss of peptide interaction for the first WW domain.	Proline	20-27	WW domain-containing oxidoreductase	Rattus norvegicus	81-85
23974298-4	2014	This interaction is mediated by the CAS SRC homology 3 domain and a proline-rich sequence in the hinge region of vinculin.	Proline	68-75	vinculin	Homo sapiens	113-121
24016298-2	2014	We tested the hypothesis that this T cell reactivity could be abolished by using prolyl-endopeptidase (PEP), an enzyme that cleaves peptide bonds after proline.	Proline	152-159	prolyl endopeptidase	Homo sapiens	103-106
24534472-2	2014	Pin1 catalyzes the flip between two distinct orientations, called cis and trans, around the proline bond.	Proline	92-99	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
24136450-4	2014	In cultured human Treg cells, UXT associates with Foxp3 in the nucleus by interacting with the proline-rich domain in the N-terminus of Foxp3.	Proline	95-102	ubiquitously expressed prefoldin like chaperone	Homo sapiens	30-33
24136450-4	2014	In cultured human Treg cells, UXT associates with Foxp3 in the nucleus by interacting with the proline-rich domain in the N-terminus of Foxp3.	Proline	95-102	forkhead box P3	Homo sapiens	50-55
24136450-4	2014	In cultured human Treg cells, UXT associates with Foxp3 in the nucleus by interacting with the proline-rich domain in the N-terminus of Foxp3.	Proline	95-102	forkhead box P3	Homo sapiens	136-141
24598995-9	2014	The expression of proline biosynthetic genes (i.e. P5CS1 and P5CS2) and of genes related to priming processes (i.e. MPK3 and MPK6) were also up-regulated.	Proline	18-25	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	51-56
24598995-9	2014	The expression of proline biosynthetic genes (i.e. P5CS1 and P5CS2) and of genes related to priming processes (i.e. MPK3 and MPK6) were also up-regulated.	Proline	18-25	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	61-66
24428215-6	2014	A single base "G" deletion at nucleotide 246 (c. 246delG) was identified in exon 5 of the CLCN5 gene in this patient, resulting in a frame shift mutation (fsX) that changed the Threonine (Thr) residue in position 83 to Proline (Pro).	Proline	219-226	chloride voltage-gated channel 5	Homo sapiens	90-95
24428215-6	2014	A single base "G" deletion at nucleotide 246 (c. 246delG) was identified in exon 5 of the CLCN5 gene in this patient, resulting in a frame shift mutation (fsX) that changed the Threonine (Thr) residue in position 83 to Proline (Pro).	Proline	219-222	chloride voltage-gated channel 5	Homo sapiens	90-95
24709419-9	2014	Further, we identify two conserved proline (P) residues in UBCH5 critical for SMURF2 interaction; mutation of either of these P to alanine also destabilizes KRAS.	Proline	35-42	ubiquitin conjugating enzyme E2 D1	Homo sapiens	59-64
24337574-4	2014	The cytokines TNF and TGFbeta impair the expression of clock genes, namely the period genes and the proline- and acidic amino acid-rich basic leucine zipper (PAR-bZip) clock-controlled genes.	Proline	100-107	tumor necrosis factor	Homo sapiens	14-17
24709419-9	2014	Further, we identify two conserved proline (P) residues in UBCH5 critical for SMURF2 interaction; mutation of either of these P to alanine also destabilizes KRAS.	Proline	35-42	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	78-84
23819464-3	2014	METHODS: We employed an established mouse model of follicular thyroid cancer (FTC) with a homozygous proline to valine mutation (Thrb(PV/PV)) in the thyroid receptor beta1 (TRbeta1) and applied quantitative three-dimensional (3D) telomere analysis to determine 3D telomeric profiles in Thrb(PV)(/PV), Thrb(PV/)(+), and Thrb(+/+) mouse thyrocytes before and after histological presentation of FTC.	Proline	101-108	thyroid hormone receptor beta	Mus musculus	129-133
24337574-4	2014	The cytokines TNF and TGFbeta impair the expression of clock genes, namely the period genes and the proline- and acidic amino acid-rich basic leucine zipper (PAR-bZip) clock-controlled genes.	Proline	100-107	transforming growth factor beta 1	Homo sapiens	22-29
24291222-4	2014	Previous work established that the proline-rich domain within the cytosolic N-terminus of FasL is required for protein-protein interactions with different Src homology 3 (SH3) or WW domain proteins.	Proline	35-42	Fas ligand	Homo sapiens	90-94
24498195-1	2014	Cyclin-dependent kinase 5 is a proline-directed serine/threonine kinase and its activity participates in the regulation of nociceptive signaling.	Proline	31-38	cyclin dependent kinase 5	Homo sapiens	0-25
24474782-4	2014	Domain delineation of the 120-kDa CagA protein revealed a stable N-terminal subdomain that was used in a yeast two-hybrid screen that identified the proline-rich domain of ASPP2 as a host cellular target.	Proline	149-156	S100 calcium binding protein A8	Homo sapiens	34-38
24474782-4	2014	Domain delineation of the 120-kDa CagA protein revealed a stable N-terminal subdomain that was used in a yeast two-hybrid screen that identified the proline-rich domain of ASPP2 as a host cellular target.	Proline	149-156	tumor protein p53 binding protein 2	Homo sapiens	172-177
24474782-6	2014	The cocrystal structure to 2.0-A resolution of this N-terminal subdomain of CagA with a 7-kDa proline-rich sequence of ASPP2 reveals that this domain of CagA forms a highly specialized three-helix bundle, with large insertions in the loops connecting the helices.	Proline	94-101	S100 calcium binding protein A8	Homo sapiens	76-80
24474782-6	2014	The cocrystal structure to 2.0-A resolution of this N-terminal subdomain of CagA with a 7-kDa proline-rich sequence of ASPP2 reveals that this domain of CagA forms a highly specialized three-helix bundle, with large insertions in the loops connecting the helices.	Proline	94-101	tumor protein p53 binding protein 2	Homo sapiens	119-124
24474782-6	2014	The cocrystal structure to 2.0-A resolution of this N-terminal subdomain of CagA with a 7-kDa proline-rich sequence of ASPP2 reveals that this domain of CagA forms a highly specialized three-helix bundle, with large insertions in the loops connecting the helices.	Proline	94-101	S100 calcium binding protein A8	Homo sapiens	153-157
24475245-6	2014	We could show that ArgBP2 oligomerization involves the binding of one of its SH3 domains to a specific proline rich cluster.	Proline	103-110	sorbin and SH3 domain containing 2	Homo sapiens	19-25
24211660-4	2014	We identified a set of 63 candidate protein interactions, including 36 proteins interacting with dynamin-1 C-terminal proline-rich domain (PRD), 14 with pleckstrin-homology domain (PH), 7 with GTPase effector domain (GED) and 6 with GTPase domain, consisting of synaptic vesicle-associated proteins, cytoskeletal proteins, metabolic enzymes and other proteins.	Proline	118-125	dynamin 1	Rattus norvegicus	97-106
25422197-11	2014	The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% and 33.66%) as compared to p53 pro/pro variant (25.74%) in the healthy population.	Proline	57-60	tumor protein p53	Homo sapiens	16-19
24520212-4	2014	WWOX can interact via the WW domain with proteins that possess proline PPxY motifs and is involved in a variety of cellular processes.	Proline	63-70	WW domain-containing oxidoreductase	Mus musculus	0-4
24184981-10	2014	We found that [Leu(31), Pro(34)]-NPY reduced paw clamp-induced NK1R internalization in CFA rats but not uninjured controls.	Proline	24-27	neuropeptide Y	Rattus norvegicus	33-36
24184981-10	2014	We found that [Leu(31), Pro(34)]-NPY reduced paw clamp-induced NK1R internalization in CFA rats but not uninjured controls.	Proline	24-27	tachykinin receptor 1	Rattus norvegicus	63-67
24383403-3	2014	Collagen prolyl-4-hydroxylase alpha subunit 2 (P4HA2), an enzyme hydroxylating proline residues in -X-Pro-Gly- sequences, is a potential therapeutic target for the disorders associated with increased collagen deposition.	Proline	79-86	prolyl 4-hydroxylase subunit alpha 2	Homo sapiens	9-45
24383403-3	2014	Collagen prolyl-4-hydroxylase alpha subunit 2 (P4HA2), an enzyme hydroxylating proline residues in -X-Pro-Gly- sequences, is a potential therapeutic target for the disorders associated with increased collagen deposition.	Proline	79-86	prolyl 4-hydroxylase subunit alpha 2	Homo sapiens	47-52
24068478-2	2014	The secreted, mature form of human FGF4 is thought to be comprised of 175 amino acid residues (proline(32) to leucine(206), Pro(32)-Leu(206)).	Proline	124-127	fibroblast growth factor 4	Homo sapiens	35-39
24935583-6	2014	Structure and functional analysis revealed that the SNP in the proline rich domain is responsible for interaction with HRMT1L2 and WWOX.	Proline	63-70	protein arginine methyltransferase 1	Homo sapiens	119-126
24935583-6	2014	Structure and functional analysis revealed that the SNP in the proline rich domain is responsible for interaction with HRMT1L2 and WWOX.	Proline	63-70	WW domain containing oxidoreductase	Homo sapiens	131-135
24410747-2	2014	ProDH converts Pro into  1 pyrroline-5-carboxylate (P5C) and can act together with P5C dehydrogenase (P5CDH) to produce Glu, or with P5C reductase (P5CR) to regenerate Pro and thus stimulate the Pro/P5C cycle.	Proline	0-3	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	83-100
24410747-2	2014	ProDH converts Pro into  1 pyrroline-5-carboxylate (P5C) and can act together with P5C dehydrogenase (P5CDH) to produce Glu, or with P5C reductase (P5CR) to regenerate Pro and thus stimulate the Pro/P5C cycle.	Proline	0-3	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	102-107
24410747-2	2014	ProDH converts Pro into  1 pyrroline-5-carboxylate (P5C) and can act together with P5C dehydrogenase (P5CDH) to produce Glu, or with P5C reductase (P5CR) to regenerate Pro and thus stimulate the Pro/P5C cycle.	Proline	0-3	pyrroline-5- carboxylate (P5C) reductase	Arabidopsis thaliana	133-146
24410747-2	2014	ProDH converts Pro into  1 pyrroline-5-carboxylate (P5C) and can act together with P5C dehydrogenase (P5CDH) to produce Glu, or with P5C reductase (P5CR) to regenerate Pro and thus stimulate the Pro/P5C cycle.	Proline	0-3	pyrroline-5- carboxylate (P5C) reductase	Arabidopsis thaliana	148-152
24360785-5	2014	Mrp10 contains an unconventional proline-rich matrix-targeting sequence that renders import intermediates accessible to Mia40.	Proline	33-40	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	120-125
24269815-1	2014	Prolyl oligopeptidase (POP) is a serine endopeptidase that hydrolyzes post-proline peptide bonds in peptides that are &lt;30 amino acids in length.	Proline	75-82	prolyl endopeptidase	Homo sapiens	0-21
24269815-1	2014	Prolyl oligopeptidase (POP) is a serine endopeptidase that hydrolyzes post-proline peptide bonds in peptides that are &lt;30 amino acids in length.	Proline	75-82	prolyl endopeptidase	Homo sapiens	23-26
24222668-9	2014	In agreement, uptake studies of l-proline, a PAT1 substrate, in A7r5 cells suggested an alternative role for PAT1 in SMCs than in transport.	Proline	32-41	solute carrier family 36 (proton/amino acid symporter), member 1	Mus musculus	45-49
24206178-5	2014	The saposin like type-B domain of CjNKL contained the six essential cysteines, one proline, 15 cationic amino acids residues, and an antibacterial region that are characteristic of NKL proteins.	Proline	83-90	antimicrobial peptide NK-lysin	Coturnix japonica	34-39
24206178-5	2014	The saposin like type-B domain of CjNKL contained the six essential cysteines, one proline, 15 cationic amino acids residues, and an antibacterial region that are characteristic of NKL proteins.	Proline	83-90	antimicrobial peptide NK-lysin	Coturnix japonica	36-39
24492713-1	2014	Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains a pleckstrin homology (PH), Src homology 2 (SH2)-like domains, and proline-rich regions in its C-terminal.	Proline	168-175	signal transducing adaptor family member 2	Mus musculus	0-36
24492713-1	2014	Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains a pleckstrin homology (PH), Src homology 2 (SH2)-like domains, and proline-rich regions in its C-terminal.	Proline	168-175	signal transducing adaptor family member 2	Mus musculus	38-44
25485500-8	2014	Moreover, our studies confirm that the subsequently trans/cis proline isomerization of (T/S)P motif by the Pin1 prolyl-isomerase, could modulate the E3-ligase interaction, and that the (T/S)pPtransPPxY motif represent the best conformer for the ItchWW-(T/S)PPPxY motif recognition.	Proline	62-69	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	107-111
25140306-1	2014	A cell surface serine protease, dipeptidyl peptidase 4 (DPP-4), cleaves dipeptide from peptides containing proline or alanine in the N-terminal penultimate position.	Proline	107-114	coagulation factor II, thrombin	Homo sapiens	15-30
25140306-1	2014	A cell surface serine protease, dipeptidyl peptidase 4 (DPP-4), cleaves dipeptide from peptides containing proline or alanine in the N-terminal penultimate position.	Proline	107-114	dipeptidyl peptidase 4	Homo sapiens	32-54
25140306-1	2014	A cell surface serine protease, dipeptidyl peptidase 4 (DPP-4), cleaves dipeptide from peptides containing proline or alanine in the N-terminal penultimate position.	Proline	107-114	dipeptidyl peptidase 4	Homo sapiens	56-61
22339171-3	2014	In our previous paper we showed that the MMP-9 enzyme recognizes a specific peptide sequence, Lys-Gly- Pro-Arg-Ser-Leu-Ser-Gly-Lys, and cleaves the peptide into two parts [1].	Proline	103-106	matrix metallopeptidase 9	Homo sapiens	41-46
25324000-9	2014	Investigations also tested the hypothesis that PRCP cleavage site on PK is between its C-terminal Pro 637 (P(637)) and Ala 638 (A(638)).	Proline	98-101	prolylcarboxypeptidase	Homo sapiens	47-51
24267382-5	2014	Pin1 specifically binds to a phosphopeptide corresponding to the L3 loop of Sp140-PHD and catalyzes cis-trans isomerization of a pThr-Pro bond.	Proline	134-137	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
24267382-5	2014	Pin1 specifically binds to a phosphopeptide corresponding to the L3 loop of Sp140-PHD and catalyzes cis-trans isomerization of a pThr-Pro bond.	Proline	134-137	SP140 nuclear body protein	Homo sapiens	76-81
24699279-5	2014	The AChE species capable of triggering the biggest increase in PS1 levels is a complex of AChE with the membrane anchoring subunit proline-rich membrane anchor (PRiMA), which restricts the localization of the resulting AChE tetramer to the outer plasma membrane.	Proline	131-138	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-8
24520497-2	2014	FABP9/PERF15 (Perforatorial15) is the male germ cell-specific fatty acid-binding pro- tein.	Proline	81-84	fatty acid binding protein 9	Homo sapiens	0-5
24520497-2	2014	FABP9/PERF15 (Perforatorial15) is the male germ cell-specific fatty acid-binding pro- tein.	Proline	81-84	fatty acid binding protein 9	Homo sapiens	6-12
24699279-5	2014	The AChE species capable of triggering the biggest increase in PS1 levels is a complex of AChE with the membrane anchoring subunit proline-rich membrane anchor (PRiMA), which restricts the localization of the resulting AChE tetramer to the outer plasma membrane.	Proline	131-138	presenilin 1	Homo sapiens	63-66
24699279-5	2014	The AChE species capable of triggering the biggest increase in PS1 levels is a complex of AChE with the membrane anchoring subunit proline-rich membrane anchor (PRiMA), which restricts the localization of the resulting AChE tetramer to the outer plasma membrane.	Proline	131-138	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-94
24699279-5	2014	The AChE species capable of triggering the biggest increase in PS1 levels is a complex of AChE with the membrane anchoring subunit proline-rich membrane anchor (PRiMA), which restricts the localization of the resulting AChE tetramer to the outer plasma membrane.	Proline	131-138	proline rich membrane anchor 1	Homo sapiens	161-166
24699279-5	2014	The AChE species capable of triggering the biggest increase in PS1 levels is a complex of AChE with the membrane anchoring subunit proline-rich membrane anchor (PRiMA), which restricts the localization of the resulting AChE tetramer to the outer plasma membrane.	Proline	131-138	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-94
25491753-7	2014	The Pfl01_0728 and Pfl01_3768 double mutant unexpectedly exhibited stronger responses toward the tomato root exudate and amino acids such as proline, asparagine, methionine, and phenylalanine than those of the wild-type strain.	Proline	141-148	PFL01_RS03685	Pseudomonas fluorescens Pf0-1	4-14
23685991-3	2014	The replacement of Ser123, Ser173 and Thr180 into alanines at the proline-rich linker region of IRF3 abolishes BGLF4-mediated suppression.	Proline	66-73	interferon regulatory factor 3	Homo sapiens	96-100
24173213-4	2014	Strikingly, Rta homolog analysis reveals that prolines constitute 17% of conserved residues.	Proline	46-54	MAS related GPR family member F	Homo sapiens	12-15
24173213-6	2014	We previously demonstrated that proline content determines Rta homotetramerization and function.	Proline	32-39	MAS related GPR family member F	Homo sapiens	59-62
24173213-7	2014	We hypothesize that proline-directed modifications regulate Rta function by controlling binding to peptidyl-prolyl cis/trans isomerases (PPIases).	Proline	20-27	MAS related GPR family member F	Homo sapiens	60-63
24377937-4	2014	MICAL-L1 has a calponin homology, Lin11, Isl-1 &amp; Mec-3 (LIM), proline-rich, and coiled-coil domains.	Proline	66-73	MICAL like 1	Homo sapiens	0-8
24173718-6	2014	In contrast, the NEAT1-binding paraspeckle protein splicing factor proline/glutamine-rich (SFPQ) is required for ADARB2 transcription.	Proline	67-74	nuclear paraspeckle assembly transcript 1	Homo sapiens	17-22
25491753-7	2014	The Pfl01_0728 and Pfl01_3768 double mutant unexpectedly exhibited stronger responses toward the tomato root exudate and amino acids such as proline, asparagine, methionine, and phenylalanine than those of the wild-type strain.	Proline	141-148	PFL01_RS18910	Pseudomonas fluorescens Pf0-1	19-29
24173718-6	2014	In contrast, the NEAT1-binding paraspeckle protein splicing factor proline/glutamine-rich (SFPQ) is required for ADARB2 transcription.	Proline	67-74	splicing factor proline and glutamine rich	Homo sapiens	91-95
24163442-5	2014	We also identify evolutionarily conserved SIRT6 phosphorylations, including four within a proline-rich disordered region, and show that the conserved S338 phosphorylation can modulate selected SIRT6 interactions.	Proline	90-97	sirtuin 6	Homo sapiens	193-198
24465224-2	2014	These proteins, together with cyclophilin B (encoded by PPIB), form a complex that 3-hydroxylates a single proline residue on the alpha1(I) chain (Pro986) and has cis/trans isomerase (PPIase) activity essential for proper collagen folding.	Proline	107-114	peptidylprolyl isomerase B	Mus musculus	30-43
24113748-4	2014	Using a yeast two-hybrid screen, FKBP12 was identified as specifically interacting with OPRM1 at the Pro(353) residue.	Proline	101-104	FKBP prolyl isomerase 1A	Homo sapiens	33-39
24113748-4	2014	Using a yeast two-hybrid screen, FKBP12 was identified as specifically interacting with OPRM1 at the Pro(353) residue.	Proline	101-104	opioid receptor mu 1	Homo sapiens	88-93
24452013-3	2014	The carboxy-terminal proline-rich domain of DAZAP1 interacts with and neutralizes general splicing inhibitors, and is sufficient to activate splicing when recruited to pre-mRNA.	Proline	21-28	DAZ associated protein 1	Homo sapiens	44-50
24173718-6	2014	In contrast, the NEAT1-binding paraspeckle protein splicing factor proline/glutamine-rich (SFPQ) is required for ADARB2 transcription.	Proline	67-74	adenosine deaminase RNA specific B2 (inactive)	Homo sapiens	113-119
24465224-2	2014	These proteins, together with cyclophilin B (encoded by PPIB), form a complex that 3-hydroxylates a single proline residue on the alpha1(I) chain (Pro986) and has cis/trans isomerase (PPIase) activity essential for proper collagen folding.	Proline	107-114	peptidylprolyl isomerase B	Mus musculus	56-60
24465224-2	2014	These proteins, together with cyclophilin B (encoded by PPIB), form a complex that 3-hydroxylates a single proline residue on the alpha1(I) chain (Pro986) and has cis/trans isomerase (PPIase) activity essential for proper collagen folding.	Proline	107-114	peptidylprolyl isomerase (cyclophilin)-like 3	Mus musculus	184-190
24000822-5	2014	The inhibitor was stabilized by hydrogen bonding interactions with residues Arg 145, Asn 566, Pro 731 and His 732 of hECE-1.	Proline	94-97	endothelin converting enzyme 1	Homo sapiens	117-123
23839950-0	2014	Modulating the folding stability and ligand binding affinity of Pin1 WW domain by proline ring puckering.	Proline	82-89	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	64-68
23738778-11	2013	A proline residue, which is present in the ClC protein channel"s conductance pore, proved to be critical for Cl(-) transport selectivity.	Proline	2-9	Gef1p	Saccharomyces cerevisiae S288C	43-46
24235147-4	2013	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine-threonine kinase that is involved in various neuronal processes.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
24235147-4	2013	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine-threonine kinase that is involved in various neuronal processes.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
24354772-5	2014	Our study indicates that the inserted Pro residue facilitates the exposure of RGD and the binding of the peptide to glycoprotein IIb/IIIa (GPIIb/IIIa).	Proline	38-41	integrin subunit alpha 2b	Homo sapiens	139-144
23824663-2	2014	Proline-fueled mitochondrial metabolism involves the oxidative conversion of L-Proline to L-Glutamate in two enzymatic steps by means of Put1p and Put2p that help Saccharomyces cerevisiae to respond to changes in the nutritional environment by initiating the breakdown of L-Proline as a source for nitrogen, carbon, and energy.	Proline	0-7	proline dehydrogenase	Saccharomyces cerevisiae S288C	137-142
23824663-2	2014	Proline-fueled mitochondrial metabolism involves the oxidative conversion of L-Proline to L-Glutamate in two enzymatic steps by means of Put1p and Put2p that help Saccharomyces cerevisiae to respond to changes in the nutritional environment by initiating the breakdown of L-Proline as a source for nitrogen, carbon, and energy.	Proline	0-7	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	147-152
23824663-2	2014	Proline-fueled mitochondrial metabolism involves the oxidative conversion of L-Proline to L-Glutamate in two enzymatic steps by means of Put1p and Put2p that help Saccharomyces cerevisiae to respond to changes in the nutritional environment by initiating the breakdown of L-Proline as a source for nitrogen, carbon, and energy.	Proline	77-86	proline dehydrogenase	Saccharomyces cerevisiae S288C	137-142
23824663-2	2014	Proline-fueled mitochondrial metabolism involves the oxidative conversion of L-Proline to L-Glutamate in two enzymatic steps by means of Put1p and Put2p that help Saccharomyces cerevisiae to respond to changes in the nutritional environment by initiating the breakdown of L-Proline as a source for nitrogen, carbon, and energy.	Proline	77-86	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	147-152
23824663-2	2014	Proline-fueled mitochondrial metabolism involves the oxidative conversion of L-Proline to L-Glutamate in two enzymatic steps by means of Put1p and Put2p that help Saccharomyces cerevisiae to respond to changes in the nutritional environment by initiating the breakdown of L-Proline as a source for nitrogen, carbon, and energy.	Proline	272-281	proline dehydrogenase	Saccharomyces cerevisiae S288C	137-142
23824663-2	2014	Proline-fueled mitochondrial metabolism involves the oxidative conversion of L-Proline to L-Glutamate in two enzymatic steps by means of Put1p and Put2p that help Saccharomyces cerevisiae to respond to changes in the nutritional environment by initiating the breakdown of L-Proline as a source for nitrogen, carbon, and energy.	Proline	272-281	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	147-152
23824663-3	2014	Compartmentalization of L-Proline catabolic pathway implies that extensive L-Proline transport must take place between the cytosol where its biogenesis via Pro1p, Pro2p, Pro3p occurs and mitochondria.	Proline	24-33	glutamate 5-kinase	Saccharomyces cerevisiae S288C	156-161
23824663-3	2014	Compartmentalization of L-Proline catabolic pathway implies that extensive L-Proline transport must take place between the cytosol where its biogenesis via Pro1p, Pro2p, Pro3p occurs and mitochondria.	Proline	24-33	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	170-175
23824663-3	2014	Compartmentalization of L-Proline catabolic pathway implies that extensive L-Proline transport must take place between the cytosol where its biogenesis via Pro1p, Pro2p, Pro3p occurs and mitochondria.	Proline	75-84	glutamate 5-kinase	Saccharomyces cerevisiae S288C	156-161
23824663-3	2014	Compartmentalization of L-Proline catabolic pathway implies that extensive L-Proline transport must take place between the cytosol where its biogenesis via Pro1p, Pro2p, Pro3p occurs and mitochondria.	Proline	75-84	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	170-175
24391960-2	2013	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase whose function has been implicated in the brain reward circuit.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
24391960-2	2013	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase whose function has been implicated in the brain reward circuit.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
24127724-5	2013	Here we show that Hyp-containing elastin polypeptides have flexible molecular structures, analogously to proline-containing polypeptides.	Proline	105-112	elastin	Homo sapiens	33-40
24262149-7	2013	More remarkably, these subtle alterations in chemical composition--incorporation of one or two fluorine atoms into a single proline residue in the 99 amino acid long protein--modulated the aggregation properties of beta2m, inducing the formation of polymorphically distinct amyloid fibrils.	Proline	124-131	beta-2-microglobulin	Homo sapiens	215-221
24198284-0	2013	An alanine-to-proline mutation in the BB-loop of TLR3 Toll/IL-1R domain switches signalling adaptor specificity from TRIF to MyD88.	Proline	14-21	toll like receptor 3	Homo sapiens	49-53
24198284-0	2013	An alanine-to-proline mutation in the BB-loop of TLR3 Toll/IL-1R domain switches signalling adaptor specificity from TRIF to MyD88.	Proline	14-21	toll like receptor 4	Homo sapiens	54-58
24198284-0	2013	An alanine-to-proline mutation in the BB-loop of TLR3 Toll/IL-1R domain switches signalling adaptor specificity from TRIF to MyD88.	Proline	14-21	interleukin 1 receptor type 1	Homo sapiens	59-64
24198284-0	2013	An alanine-to-proline mutation in the BB-loop of TLR3 Toll/IL-1R domain switches signalling adaptor specificity from TRIF to MyD88.	Proline	14-21	TIR domain containing adaptor molecule 1	Homo sapiens	117-121
24198284-0	2013	An alanine-to-proline mutation in the BB-loop of TLR3 Toll/IL-1R domain switches signalling adaptor specificity from TRIF to MyD88.	Proline	14-21	MYD88 innate immune signal transduction adaptor	Homo sapiens	125-130
24198284-1	2013	A functionally important proline residue is highly conserved in the cytosolic Toll/IL-1R signaling domains of human TLRs.	Proline	25-32	toll like receptor 4	Homo sapiens	78-82
24198284-1	2013	A functionally important proline residue is highly conserved in the cytosolic Toll/IL-1R signaling domains of human TLRs.	Proline	25-32	interleukin 1 receptor type 1	Homo sapiens	83-88
24198284-2	2013	The antiviral Toll, TLR3, is unusual because it has alanine instead of proline at this position and is the only human TLR that associates directly with the adaptor molecule TIR domain-containing adaptor inducing IFN-beta (TRIF) rather than MyD88.	Proline	71-78	toll like receptor 4	Homo sapiens	14-18
24198284-2	2013	The antiviral Toll, TLR3, is unusual because it has alanine instead of proline at this position and is the only human TLR that associates directly with the adaptor molecule TIR domain-containing adaptor inducing IFN-beta (TRIF) rather than MyD88.	Proline	71-78	toll like receptor 3	Homo sapiens	20-24
24198284-2	2013	The antiviral Toll, TLR3, is unusual because it has alanine instead of proline at this position and is the only human TLR that associates directly with the adaptor molecule TIR domain-containing adaptor inducing IFN-beta (TRIF) rather than MyD88.	Proline	71-78	TIR domain containing adaptor molecule 1	Homo sapiens	222-226
24198284-2	2013	The antiviral Toll, TLR3, is unusual because it has alanine instead of proline at this position and is the only human TLR that associates directly with the adaptor molecule TIR domain-containing adaptor inducing IFN-beta (TRIF) rather than MyD88.	Proline	71-78	MYD88 innate immune signal transduction adaptor	Homo sapiens	240-245
24198284-3	2013	In this article, we report that a mutant TLR3 that substitutes the BB-loop alanine for proline (A795P) enhances NF-kappaB activation but is incapable of mediating TRIF-dependent IFN response factor 3 responses.	Proline	87-94	toll like receptor 3	Homo sapiens	41-45
24127724-9	2013	Furthermore, our results could contribute in defining the subtle role of proline structural variants in the folding and self-assembly of elastin-inspired peptides, helping the rational design of elastin biomaterials.	Proline	73-80	elastin	Homo sapiens	137-144
24127724-9	2013	Furthermore, our results could contribute in defining the subtle role of proline structural variants in the folding and self-assembly of elastin-inspired peptides, helping the rational design of elastin biomaterials.	Proline	73-80	elastin	Homo sapiens	195-202
24163367-4	2013	A THIK2 mutant containing a proline residue (THIK2-A155P) in its second inner helix (M2) produces K(+)-selective currents with properties similar to THIK1, including inhibition by halothane and insensitivity to extracellular pH variations.	Proline	28-35	potassium two pore domain channel subfamily K member 12	Homo sapiens	2-7
24371721-3	2013	FAP"s unique and restricted cleavage of the post proline bond was exploited to generate a new specific substrate to quantify FAP enzyme activity.	Proline	49-56	fibroblast activation protein	Mus musculus	0-3
24371721-3	2013	FAP"s unique and restricted cleavage of the post proline bond was exploited to generate a new specific substrate to quantify FAP enzyme activity.	Proline	49-56	fibroblast activation protein	Mus musculus	125-128
24100026-4	2013	Although both interactions involve the glycan-binding site or its vicinity, the arm-like proline-rich (P-) domain of calreticulin contributes to binding non/deglycosylated proteins.	Proline	89-96	calreticulin	Homo sapiens	117-129
24163367-4	2013	A THIK2 mutant containing a proline residue (THIK2-A155P) in its second inner helix (M2) produces K(+)-selective currents with properties similar to THIK1, including inhibition by halothane and insensitivity to extracellular pH variations.	Proline	28-35	potassium two pore domain channel subfamily K member 12	Homo sapiens	45-50
24080088-1	2013	Bcl-2 associated athanogene 3 (BAG3) has a modular structure that contains a BAG domain, a WW domain, a proline-rich (PxxP) domain to mediate potential interactions with chaperons and other proteins that participate in more than one signal transduction.	Proline	104-111	BAG cochaperone 3	Homo sapiens	0-29
23897164-5	2013	Structural analysis indicated that P34S mutation seemed to perturb a highly conserved proline-rich N-terminus of CYP2D6.	Proline	86-93	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	113-119
23994618-5	2013	PIN1 is a peptidyl-prolyl isomerase enzyme belonging to the parvulin family, which specifically recognizes phosphorylated Ser/Thr-Pro containing substrates.	Proline	130-133	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
23994618-6	2013	Through protein-protein interaction assays, we showed that the Pro-directed Ser/Thr-Pro motif at Thr-93 in the KLF10 N-terminal region is essential for the interaction between KLF10 and PIN1.	Proline	63-66	Kruppel like factor 10	Homo sapiens	111-116
23994618-6	2013	Through protein-protein interaction assays, we showed that the Pro-directed Ser/Thr-Pro motif at Thr-93 in the KLF10 N-terminal region is essential for the interaction between KLF10 and PIN1.	Proline	63-66	Kruppel like factor 10	Homo sapiens	176-181
23994618-6	2013	Through protein-protein interaction assays, we showed that the Pro-directed Ser/Thr-Pro motif at Thr-93 in the KLF10 N-terminal region is essential for the interaction between KLF10 and PIN1.	Proline	63-66	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	186-190
24032673-3	2013	In the present study, we show in neutrophil-activating chemokine CXCL8 that the highly conserved GP (glycine-proline) motif located distal to both N-terminal and N-loop residues couples Site-I and Site-II interactions.	Proline	109-116	C-X-C motif chemokine ligand 8	Homo sapiens	65-70
24080088-1	2013	Bcl-2 associated athanogene 3 (BAG3) has a modular structure that contains a BAG domain, a WW domain, a proline-rich (PxxP) domain to mediate potential interactions with chaperons and other proteins that participate in more than one signal transduction.	Proline	104-111	BAG cochaperone 3	Homo sapiens	31-35
24132642-1	2013	Hypoxia-inducible factor 1 (HIF-1) is regulated by the oxygen-dependent hydroxylation of proline residues by prolyl hydroxylases (PHDs).	Proline	89-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
24030392-0	2013	A proline-rich loop mediates specific functions of human sialidase NEU4 in SK-N-BE neuronal differentiation.	Proline	2-9	neuraminidase 4	Homo sapiens	67-71
24030392-0	2013	A proline-rich loop mediates specific functions of human sialidase NEU4 in SK-N-BE neuronal differentiation.	Proline	2-9	hedgehog acyltransferase	Homo sapiens	75-79
24030392-4	2013	We have found that a proline-rich sequence of 81 amino acids, unique to NEU4 sequence, contains potential Akt and Erk1 kinase motifs.	Proline	21-28	neuraminidase 4	Homo sapiens	72-76
24030392-4	2013	We have found that a proline-rich sequence of 81 amino acids, unique to NEU4 sequence, contains potential Akt and Erk1 kinase motifs.	Proline	21-28	AKT serine/threonine kinase 1	Homo sapiens	106-109
24030392-5	2013	Molecular modeling, based on the experimentally determined three-dimensional structure of cytosolic human NEU2, showed that the proline-rich sequence is accommodated in a loop, thus preserving the typical beta-barrel structure of sialidases.	Proline	128-135	neuraminidase 2	Homo sapiens	106-110
24030392-7	2013	Our results demonstrate that the proline-rich region can also enhance cell proliferation and retinoic acid (RA)-induced neuronal differentiation and it is also involved in NEU4 interaction with Akt, as well as in substrate recognition, modifying directly or through the interaction with other protein(s) the enzyme specificity toward sialylated glycoprotein(s).	Proline	33-40	neuraminidase 4	Homo sapiens	172-176
24030392-7	2013	Our results demonstrate that the proline-rich region can also enhance cell proliferation and retinoic acid (RA)-induced neuronal differentiation and it is also involved in NEU4 interaction with Akt, as well as in substrate recognition, modifying directly or through the interaction with other protein(s) the enzyme specificity toward sialylated glycoprotein(s).	Proline	33-40	AKT serine/threonine kinase 1	Homo sapiens	194-197
23479033-2	2013	Prolidase is known to have a crucial part in the recycling of proline for collagen synthesis.	Proline	62-69	peptidase D	Homo sapiens	0-9
24038467-5	2013	In vitro binding assays show that the defects of the proline mutants are the result of impaired binding of Top3 and Rmi1 to Sgs1.	Proline	53-60	Rmi1p	Saccharomyces cerevisiae S288C	116-120
24038467-5	2013	In vitro binding assays show that the defects of the proline mutants are the result of impaired binding of Top3 and Rmi1 to Sgs1.	Proline	53-60	ATP-dependent DNA helicase SGS1	Saccharomyces cerevisiae S288C	124-128
24038467-7	2013	Depending on the position of the proline substitution in the helix functional impairment of Sgs1 function varied, gradually increasing from the C- to the N-terminus.	Proline	33-40	ATP-dependent DNA helicase SGS1	Saccharomyces cerevisiae S288C	92-96
24049075-4	2013	Here we report that MED14, a core subunit of the Mediator, is a bona fide ERK substrate and identify serine 986 (S986) within a serine-proline rich region of MED14 as the major ERK phosphorylation site.	Proline	135-142	mediator complex subunit 14	Homo sapiens	20-25
24049075-4	2013	Here we report that MED14, a core subunit of the Mediator, is a bona fide ERK substrate and identify serine 986 (S986) within a serine-proline rich region of MED14 as the major ERK phosphorylation site.	Proline	135-142	mediator complex subunit 14	Homo sapiens	158-163
24049075-4	2013	Here we report that MED14, a core subunit of the Mediator, is a bona fide ERK substrate and identify serine 986 (S986) within a serine-proline rich region of MED14 as the major ERK phosphorylation site.	Proline	135-142	mitogen-activated protein kinase 1	Homo sapiens	177-180
24185201-3	2013	Subsequently, hyperphosphorylated Upf1 associates with SMG5-7 or proline-rich nuclear receptor coregulatory protein (PNRC2) to elicit rapid mRNA degradation.	Proline	65-72	UPF1 RNA helicase and ATPase	Homo sapiens	34-38
24185201-3	2013	Subsequently, hyperphosphorylated Upf1 associates with SMG5-7 or proline-rich nuclear receptor coregulatory protein (PNRC2) to elicit rapid mRNA degradation.	Proline	65-72	proline rich nuclear receptor coactivator 2	Homo sapiens	117-122
24038034-1	2013	DPP8 and DPP9 are recently identified members of the dipeptidyl peptidase IV (DPPIV) enzyme family, which is characterized by the rare ability to cleave a post-proline bond two residues from the N-terminus of a substrate.	Proline	160-167	dipeptidyl peptidase 8	Homo sapiens	0-4
24038034-1	2013	DPP8 and DPP9 are recently identified members of the dipeptidyl peptidase IV (DPPIV) enzyme family, which is characterized by the rare ability to cleave a post-proline bond two residues from the N-terminus of a substrate.	Proline	160-167	dipeptidyl peptidase 9	Homo sapiens	9-13
24038034-1	2013	DPP8 and DPP9 are recently identified members of the dipeptidyl peptidase IV (DPPIV) enzyme family, which is characterized by the rare ability to cleave a post-proline bond two residues from the N-terminus of a substrate.	Proline	160-167	dipeptidyl peptidase 4	Homo sapiens	53-76
24038034-1	2013	DPP8 and DPP9 are recently identified members of the dipeptidyl peptidase IV (DPPIV) enzyme family, which is characterized by the rare ability to cleave a post-proline bond two residues from the N-terminus of a substrate.	Proline	160-167	dipeptidyl peptidase 4	Homo sapiens	78-83
23934343-9	2013	The CL2/gate domain is crucial for GmPYLs-PP2Cs interaction, and a mutation in the conserved proline (P109S) abolishes the interaction between GmPYL1 and AtABI1.	Proline	93-100	Protein phosphatase 2C family protein	Arabidopsis thaliana	154-160
24184451-5	2013	SlICE1a overexpression in tobacco enhances the induction of CBF/DREB and their target genes, consequently increasing the levels of proline, soluble sugars, and late embryogenesis abundant (LEA) proteins, and enhancing tolerance to cold stress, osmotic stress, and salt stress.	Proline	131-138	transcription factor ICE1-like	Solanum lycopersicum	0-7
24132642-1	2013	Hypoxia-inducible factor 1 (HIF-1) is regulated by the oxygen-dependent hydroxylation of proline residues by prolyl hydroxylases (PHDs).	Proline	89-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
24237637-8	2013	T-DNA mutants of atocd and AtOCD RNAi plants had approximately 15% higher proline accumulation at low water potential while p5cs1-4/atocd double mutants had 40% higher proline than p5cs1 at low water potential but no change in proline metabolism gene expression which could directly explain the higher proline level.	Proline	168-175	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	124-129
24126913-0	2013	Proline scanning mutagenesis reveals a role for the flap endonuclease-1 helical cap in substrate unpairing.	Proline	0-7	flap structure-specific endonuclease 1	Homo sapiens	52-71
24126913-6	2013	Proline mutations (L97P, L111P, L130P) were introduced into the hFEN1 helical arch.	Proline	0-7	flap structure-specific endonuclease 1	Homo sapiens	64-69
24191005-2	2013	OSR1 and STE20/SPS1-related proline-, alanine-rich kinase are activated by with no lysine [K] protein kinases that phosphorylate the essential activation loop regulatory site on these kinases.	Proline	28-35	oxidative stress responsive kinase 1	Homo sapiens	0-4
23873104-1	2013	NAD(P)H: quinone oxidoreductase 1 (NQO1) rs1800566 (Pro187Ser) is a functional polymorphism which leads to a proline-to-serine amino acid substitution at codon 187 in the NQO1 protein and enzyme activity changes.	Proline	109-116	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-33
23873104-1	2013	NAD(P)H: quinone oxidoreductase 1 (NQO1) rs1800566 (Pro187Ser) is a functional polymorphism which leads to a proline-to-serine amino acid substitution at codon 187 in the NQO1 protein and enzyme activity changes.	Proline	109-116	NAD(P)H quinone dehydrogenase 1	Homo sapiens	35-39
23873104-1	2013	NAD(P)H: quinone oxidoreductase 1 (NQO1) rs1800566 (Pro187Ser) is a functional polymorphism which leads to a proline-to-serine amino acid substitution at codon 187 in the NQO1 protein and enzyme activity changes.	Proline	109-116	NAD(P)H quinone dehydrogenase 1	Homo sapiens	171-175
24191005-2	2013	OSR1 and STE20/SPS1-related proline-, alanine-rich kinase are activated by with no lysine [K] protein kinases that phosphorylate the essential activation loop regulatory site on these kinases.	Proline	28-35	serine/threonine kinase 24	Homo sapiens	9-14
24237637-8	2013	T-DNA mutants of atocd and AtOCD RNAi plants had approximately 15% higher proline accumulation at low water potential while p5cs1-4/atocd double mutants had 40% higher proline than p5cs1 at low water potential but no change in proline metabolism gene expression which could directly explain the higher proline level.	Proline	168-175	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	124-129
24191005-2	2013	OSR1 and STE20/SPS1-related proline-, alanine-rich kinase are activated by with no lysine [K] protein kinases that phosphorylate the essential activation loop regulatory site on these kinases.	Proline	28-35	selenophosphate synthetase 1	Homo sapiens	15-19
24237637-8	2013	T-DNA mutants of atocd and AtOCD RNAi plants had approximately 15% higher proline accumulation at low water potential while p5cs1-4/atocd double mutants had 40% higher proline than p5cs1 at low water potential but no change in proline metabolism gene expression which could directly explain the higher proline level.	Proline	168-175	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	124-129
23871893-6	2013	With the use of a peptide library derived from Sema3F, C-1 residues that preferentially adopt an extended bound-like conformation, including proline and beta-branched amino acids, were found to produce the most avid competitors.	Proline	141-148	semaphorin 3F	Homo sapiens	47-53
23871893-6	2013	With the use of a peptide library derived from Sema3F, C-1 residues that preferentially adopt an extended bound-like conformation, including proline and beta-branched amino acids, were found to produce the most avid competitors.	Proline	141-148	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	55-58
23871893-7	2013	Consistent with this, analysis of the binding thermodynamics revealed that more favorable entropy is responsible for the observed binding enhancement of C-1 proline.	Proline	157-164	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	153-156
24078636-5	2013	Here, we report that CHERP, containing a Pro-rich region and a phosphorylated Ser/Arg-rich RS-like domain, is a novel Ca(2+)-dependent ALG-2-interactive target in the nucleus.	Proline	41-44	calcium homeostasis endoplasmic reticulum protein	Homo sapiens	21-26
23938248-7	2013	We show that Atoh8 lacks a transactivation domain and possesses intrinsic repressor activity that depends on a conserved Proline-rich domain.	Proline	121-128	atonal bHLH transcription factor 8	Homo sapiens	13-18
24078636-5	2013	Here, we report that CHERP, containing a Pro-rich region and a phosphorylated Ser/Arg-rich RS-like domain, is a novel Ca(2+)-dependent ALG-2-interactive target in the nucleus.	Proline	41-44	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	135-140
24225024-6	2013	The functionally essential proline-rich motif mediates a direct but weak interaction with residues 101-104 of EloB, inducing a conformational change from an unstructured state to a structured state.	Proline	27-34	elongin B	Homo sapiens	110-114
24106871-8	2013	The ability of FKBP65 to modulate the self-assembly of tropoelastin is independent of its enzymatic activity to promote the cis-trans isomerization of proline residues in proteins.	Proline	151-158	FKBP prolyl isomerase 10	Homo sapiens	15-21
24106871-8	2013	The ability of FKBP65 to modulate the self-assembly of tropoelastin is independent of its enzymatic activity to promote the cis-trans isomerization of proline residues in proteins.	Proline	151-158	elastin	Homo sapiens	55-67
24223981-6	2013	The proline content of transgenic A. thaliana plants fell, consistent with the down-regulation of P5CS1, while the expression of SOS1, SOS2, SOS3, CBF3 and DREB2A, which are all stress tolerance-related genes acting in an ABA-independent fashion, was also down-regulated.	Proline	4-11	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	98-103
24085300-8	2013	Three amino acids of p35, Asp-259, Asn-266, and Ser-270, which are involved in hydrogen bond formation with Cdk5, are changed to Gln, Gln, and Pro in p39.	Proline	143-146	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	21-24
24085300-8	2013	Three amino acids of p35, Asp-259, Asn-266, and Ser-270, which are involved in hydrogen bond formation with Cdk5, are changed to Gln, Gln, and Pro in p39.	Proline	143-146	cyclin dependent kinase 5	Homo sapiens	108-112
24085300-8	2013	Three amino acids of p35, Asp-259, Asn-266, and Ser-270, which are involved in hydrogen bond formation with Cdk5, are changed to Gln, Gln, and Pro in p39.	Proline	143-146	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	150-153
24052261-9	2013	The N-terminal region of FAD104, which contains a proline-rich motif, was capable of binding to Smad1/5/8.	Proline	50-57	fibronectin type III domain containing 3B	Mus musculus	25-31
23892366-3	2013	Here we identify and characterize a novel mouse mutant, yautja, and find it results from a leucine-to-proline substitution in the winged-helix domain of Apaf1.	Proline	102-109	apoptotic peptidase activating factor 1	Mus musculus	153-158
24106123-7	2013	Sequencing identified a T C point mutation in the codon for amino acid 480 in Myo6 that converts a leucine to a proline.	Proline	112-119	myosin VI	Mus musculus	78-82
24052261-9	2013	The N-terminal region of FAD104, which contains a proline-rich motif, was capable of binding to Smad1/5/8.	Proline	50-57	SMAD family member 1	Mus musculus	96-105
24068435-0	2013	Molecular evolution of plant P5CS gene involved in proline biosynthesis.	Proline	51-58	aldehyde dehydrogenase 18 family member A1	Homo sapiens	29-33
23933069-6	2013	Deletion analyses showed that both the N- and C-terminal regions contribute to the suppressive activity of Gbx2 against the anterior brain and that the N-terminal core region, including the Eh1 and proline-rich sequences, is required for this Gbx2 activity.	Proline	198-205	gastrulation brain homeobox 2	Mus musculus	107-111
24068435-1	2013	The P5CS ({Delta} 1-Pyrroline-5-Carboxylate Synthetase) gene encodes for a bifunctional enzyme that catalyzes the rate limiting reaction in proline biosynthesis in living organisms.	Proline	140-147	aldehyde dehydrogenase 18 family member A1	Homo sapiens	4-8
24068435-1	2013	The P5CS ({Delta} 1-Pyrroline-5-Carboxylate Synthetase) gene encodes for a bifunctional enzyme that catalyzes the rate limiting reaction in proline biosynthesis in living organisms.	Proline	140-147	aldehyde dehydrogenase 18 family member A1	Homo sapiens	11-54
24068435-3	2013	The proline biosynthetic genes, especially, P5CS is commonly used in metabolic engineering for proline overproduction conferring stress tolerance in plants.	Proline	4-11	aldehyde dehydrogenase 18 family member A1	Homo sapiens	44-48
24068435-3	2013	The proline biosynthetic genes, especially, P5CS is commonly used in metabolic engineering for proline overproduction conferring stress tolerance in plants.	Proline	95-102	aldehyde dehydrogenase 18 family member A1	Homo sapiens	44-48
24038880-4	2013	Our results revealed that following the removal of the initiation Met residue of yeast Rpt1, the N-terminal Pro residue is either unmodified, mono-methylated, or di-methylated, and that this N-methylation has not been conserved throughout evolution.	Proline	108-111	proteasome regulatory particle base subunit RPT1	Saccharomyces cerevisiae S288C	87-91
24038880-5	2013	In order to gain a better understanding of the possible function(s) of the Pro-Lys (PK) sequence at positions 3 and 4 of yeast Rpt1, we generated mutant strains expressing an Rpt1 allele that lacks this sequence.	Proline	75-78	proteasome regulatory particle base subunit RPT1	Saccharomyces cerevisiae S288C	127-131
25606382-2	2013	Polymorphism of p53 gene codon 72 Arg/Pro (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.	Proline	38-41	tumor protein p53	Homo sapiens	16-19
24035636-1	2013	Autosomal recessive cutis laxa type 2B (ARCL2B; OMIM # 612940) is a segmental progeroid disorder caused by mutations in PYCR1 encoding pyrroline-5-carboxylate reductase 1, which is part of the conserved proline de novo synthesis pathway.	Proline	203-210	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-38
24035636-1	2013	Autosomal recessive cutis laxa type 2B (ARCL2B; OMIM # 612940) is a segmental progeroid disorder caused by mutations in PYCR1 encoding pyrroline-5-carboxylate reductase 1, which is part of the conserved proline de novo synthesis pathway.	Proline	203-210	pyrroline-5-carboxylate reductase 1	Homo sapiens	40-46
24035636-1	2013	Autosomal recessive cutis laxa type 2B (ARCL2B; OMIM # 612940) is a segmental progeroid disorder caused by mutations in PYCR1 encoding pyrroline-5-carboxylate reductase 1, which is part of the conserved proline de novo synthesis pathway.	Proline	203-210	pyrroline-5-carboxylate reductase 1	Homo sapiens	120-125
24035636-1	2013	Autosomal recessive cutis laxa type 2B (ARCL2B; OMIM # 612940) is a segmental progeroid disorder caused by mutations in PYCR1 encoding pyrroline-5-carboxylate reductase 1, which is part of the conserved proline de novo synthesis pathway.	Proline	203-210	pyrroline-5-carboxylate reductase 1	Homo sapiens	135-170
24035636-4	2013	Intrauterine growth retardation, a characteristic triangular facial gestalt, psychomotor retardation, and hypotonia were the most relevant distinctive hallmarks of ARCL due to proline de novo synthesis defects.	Proline	176-183	ATPase H+ transporting V0 subunit a2	Homo sapiens	164-168
23801378-1	2013	The yeast scaffold protein Pan1 contains two EH domains at its N-terminus, a predicted coiled-coil central region, and a C-terminal proline-rich domain.	Proline	132-139	Pan1p	Saccharomyces cerevisiae S288C	27-31
25606382-2	2013	Polymorphism of p53 gene codon 72 Arg/Pro (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.	Proline	38-41	tumor protein p53	Homo sapiens	84-87
25606382-3	2013	It has been suggested that p53 codon 72 Arg/Pro polymorphism is associated with susceptibility to hepatocellular carcinoma (HCC).	Proline	44-47	tumor protein p53	Homo sapiens	27-30
25606382-10	2013	CONCLUSIONS/SIGNIFICANCE: This meta-analysis suggests that p53 codon 72 Arg/Pro polymorphism may be associated with the risk of HCC, especially in subgroup analysis of Asian and Caucasian population, hospital-based population, the female, and the individuals infected with hepatitis virus.	Proline	76-79	tumor protein p53	Homo sapiens	59-62
24121633-5	2013	The hnRNP L binds to another splicing repressor PTB through the proline-rich region and promotes PTB binding to the polypyrimidine tract upstream of exon P3A, whereas hnRNP LL lacking the proline-rich region cannot bind to PTB.	Proline	64-71	polypyrimidine tract binding protein 1	Homo sapiens	97-100
24243016-3	2013	FinMajor results in a proline-phenylalanine-glutamine peptide insertion within the uncharacterized Gle1 coiled-coil domain.	Proline	22-29	GLE1 RNA export mediator	Homo sapiens	99-103
24121633-5	2013	The hnRNP L binds to another splicing repressor PTB through the proline-rich region and promotes PTB binding to the polypyrimidine tract upstream of exon P3A, whereas hnRNP LL lacking the proline-rich region cannot bind to PTB.	Proline	188-195	heterogeneous nuclear ribonucleoprotein L	Homo sapiens	4-11
24121633-5	2013	The hnRNP L binds to another splicing repressor PTB through the proline-rich region and promotes PTB binding to the polypyrimidine tract upstream of exon P3A, whereas hnRNP LL lacking the proline-rich region cannot bind to PTB.	Proline	64-71	heterogeneous nuclear ribonucleoprotein L	Homo sapiens	4-11
24121633-5	2013	The hnRNP L binds to another splicing repressor PTB through the proline-rich region and promotes PTB binding to the polypyrimidine tract upstream of exon P3A, whereas hnRNP LL lacking the proline-rich region cannot bind to PTB.	Proline	188-195	polypyrimidine tract binding protein 1	Homo sapiens	48-51
24121633-5	2013	The hnRNP L binds to another splicing repressor PTB through the proline-rich region and promotes PTB binding to the polypyrimidine tract upstream of exon P3A, whereas hnRNP LL lacking the proline-rich region cannot bind to PTB.	Proline	64-71	polypyrimidine tract binding protein 1	Homo sapiens	48-51
24121633-5	2013	The hnRNP L binds to another splicing repressor PTB through the proline-rich region and promotes PTB binding to the polypyrimidine tract upstream of exon P3A, whereas hnRNP LL lacking the proline-rich region cannot bind to PTB.	Proline	64-71	polypyrimidine tract binding protein 1	Homo sapiens	97-100
24121633-5	2013	The hnRNP L binds to another splicing repressor PTB through the proline-rich region and promotes PTB binding to the polypyrimidine tract upstream of exon P3A, whereas hnRNP LL lacking the proline-rich region cannot bind to PTB.	Proline	188-195	polypyrimidine tract binding protein 1	Homo sapiens	97-100
24121633-5	2013	The hnRNP L binds to another splicing repressor PTB through the proline-rich region and promotes PTB binding to the polypyrimidine tract upstream of exon P3A, whereas hnRNP LL lacking the proline-rich region cannot bind to PTB.	Proline	188-195	polypyrimidine tract binding protein 1	Homo sapiens	97-100
24121667-2	2013	CDK5 is a proline-directed serine/threonine kinase playing important roles in cancer progression.	Proline	10-17	cyclin dependent kinase 5	Homo sapiens	0-4
23867765-7	2013	Moreover, the proline-induced increase on AChE activity was completely reverted by acute administration of antipsychotic drugs (haloperidol and sulpiride), as well as the changes induced in ache expression.	Proline	14-21	acetylcholinesterase	Danio rerio	190-194
23867765-0	2013	Proline-induced changes in acetylcholinesterase activity and gene expression in zebrafish brain: reversal by antipsychotic drugs.	Proline	0-7	acetylcholinesterase	Danio rerio	27-47
24349641-0	2013	Effects of the Arg-Pro and Gly-Gly-Nle Moieties on Melanocortin-1 Receptor Binding Affinities of alpha-MSH Peptides.	Proline	19-22	pro-opiomelanocortin-alpha	Mus musculus	97-106
23867765-3	2013	In the present study, we evaluated the in vivo and in vitro effects of proline on acetylcholinesterase (AChE) activity and gene expression in the zebrafish brain.	Proline	71-78	acetylcholinesterase	Danio rerio	82-102
24319666-4	2013	Consistently, L-Pro-induced esMT is fully reversible either after L-Pro withdrawal or by addition of ascorbic acid (vitamin C), which in turn reduces H3K9 and H3K36 methylation, promoting a mesenchymal-like-to-embryonic-stem-cell transition (MesT).	Proline	14-19	mesoderm specific transcript	Homo sapiens	242-246
23867765-3	2013	In the present study, we evaluated the in vivo and in vitro effects of proline on acetylcholinesterase (AChE) activity and gene expression in the zebrafish brain.	Proline	71-78	acetylcholinesterase	Danio rerio	104-108
23867765-6	2013	Long-term proline exposures significantly increased AChE activity for both treated groups when compared to the control (34% and 39%).	Proline	10-17	acetylcholinesterase	Danio rerio	52-56
23867765-7	2013	Moreover, the proline-induced increase on AChE activity was completely reverted by acute administration of antipsychotic drugs (haloperidol and sulpiride), as well as the changes induced in ache expression.	Proline	14-21	acetylcholinesterase	Danio rerio	42-46
24050991-9	2013	Expression analysis of Delta(1) pyrroline-5-carboxylate synthetase (P5CS) through real time PCR and enzyme activity studies showed a strong positive correlation between VrP5CS gene expression, enzyme activity and proline accumulation in the roots of V. radiata under progressive drought and recovery.	Proline	213-220	delta-1-pyrroline-5-carboxylate synthase	Vigna radiata	23-66
24105423-0	2013	Conformational change of Sos-derived proline-rich peptide upon binding Grb2 N-terminal SH3 domain probed by NMR.	Proline	37-44	growth factor receptor bound protein 2	Homo sapiens	71-75
24105423-2	2013	The N-terminal SH3 (nSH3) domain of Grb2 binds a proline-rich region present in the guanine nucleotide releasing factor, son of sevenless (Sos).	Proline	49-56	growth factor receptor bound protein 2	Homo sapiens	36-40
24105423-3	2013	Using NMR relaxation dispersion and chemical shift analysis methods, we investigated the conformational change of the Sos-derived proline-rich peptide during the transition between the free and Grb2 nSH3-bound states.	Proline	130-137	growth factor receptor bound protein 2	Homo sapiens	194-198
24098371-8	2013	Besides, correlation analysis showed that soil storage in 40-160 cm soil was negatively correlated with proline content in grains; proline content in grains was positively correlated with GS and GDH activity in flag leaves.	Proline	131-138	glutamate dehydrogenase 1, mitochondrial	Triticum aestivum	195-198
24100331-0	2013	Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.	Proline	86-93	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	32-54
24100556-3	2013	Besides the F-box motif, Fbxo7 also contains a C-terminal proline-rich region, an N-terminal ubiquitin-like domain and a novel FP (Fbxo7/PI31) domain preceding the F-box motif.	Proline	58-65	F-box protein 7	Homo sapiens	25-30
23925886-4	2013	With these modifications separately or in combination, rabbit antisera to the recombinant alpha-helical or proline-rich domains of PspA mediated &gt;50% killing of the target strain.	Proline	107-114	surfactant protein A1	Homo sapiens	131-135
23949913-5	2013	These data confirm that missense mutations altering the proline at codon 148 of MSX2 cause dominantly inherited craniosynostosis.	Proline	56-63	msh homeobox 2	Homo sapiens	80-84
23837945-8	2013	RESULTS: Patients carrying p53 Arg/Arg or Arg/Pro had a higher risk of esophageal SCC (P&lt;0.001, Odds ratio [OR] 4.98, 95% confidential interval [CI] 3.46-7.17), however, not found in MDM2 rs937283.	Proline	46-49	tumor protein p53	Homo sapiens	27-30
23758815-0	2013	Pinpointing proline substitution to be responsible for the loss of amyloidogenesis in IAPP.	Proline	12-19	islet amyloid polypeptide	Homo sapiens	86-90
23758815-2	2013	This observed non-amyloidogenecity of rodent IAPP has been attributed to substitutions by proline in a region of IAPP that forms the core of the fibril.	Proline	90-97	islet amyloid polypeptide	Homo sapiens	45-49
23758815-2	2013	This observed non-amyloidogenecity of rodent IAPP has been attributed to substitutions by proline in a region of IAPP that forms the core of the fibril.	Proline	90-97	islet amyloid polypeptide	Homo sapiens	113-117
23758815-3	2013	By employing molecular dynamics simulation, we have analyzed effects of position-specific proline substitution on amyloidogenesis of the core region of the hIAPP fibril (22-28).	Proline	90-97	islet amyloid polypeptide	Homo sapiens	156-161
23507360-5	2013	Dietary supplementation with proline significantly increased serum C-reactive protein levels (P= 0 03) in PCV2-infected pregnant mice, and increased serum TNF-alpha levels (P= 0 01), leucocytes (P&lt; 0 05), lymphocytes (P&lt; 0 05) and neutrophilic granulocytes (P&lt; 0 05) in PCV2-infected non-pregnant mice.	Proline	29-36	tumor necrosis factor	Mus musculus	155-164
23925889-0	2013	Identification of polyproline II regions derived from the proline-rich nuclear receptor coactivators PNRC and PNRC2: new insights for ERalpha coactivator interactions.	Proline	22-29	proline rich nuclear receptor coactivator 2	Homo sapiens	110-115
23925889-0	2013	Identification of polyproline II regions derived from the proline-rich nuclear receptor coactivators PNRC and PNRC2: new insights for ERalpha coactivator interactions.	Proline	22-29	estrogen receptor 1	Homo sapiens	134-141
24026126-7	2013	RNA-seq shows that loss of Mdlc decreases pros transcript levels and results in aberrant pros splicing.	Proline	42-46	midlife crisis	Drosophila melanogaster	27-31
23764530-3	2013	Three genes of pyrroline-5-carboxylate synthetase (P5CS), pyrroline-5-carboxylate reductase (P5CR) and proline dehydrogenase (ProDH) are regulating proline metabolism.	Proline	103-110	pyrroline-5-carboxylate reductase	Solanum tuberosum	58-91
24026126-7	2013	RNA-seq shows that loss of Mdlc decreases pros transcript levels and results in aberrant pros splicing.	Proline	89-93	midlife crisis	Drosophila melanogaster	27-31
24518718-9	2013	CONCLUSIONS: 2-DG could be considered as a potential therapeutic agent that induces cell death (which could be linked to induced oxidative stress) selectively in tumors with p53 mutations (particularly in the proline rich region).	Proline	209-216	tumor protein p53	Homo sapiens	174-177
23716564-4	2013	Ile533Val is a novel mutation and represents the genetic HIF2A change nearest to Pro-531, the primary hydroxyl acceptor residue, so far identified.	Proline	81-84	endothelial PAS domain protein 1	Homo sapiens	57-62
25866551-0	2013	Proline-Directed Androgen Receptor Phosphorylation.	Proline	0-7	androgen receptor	Homo sapiens	17-34
23963851-5	2013	This c.854 C &gt; T mutation resulted in a change from proline to leucine (p.P285L) in serine protease HTRA1, and was absent in 260 control chromosomes.	Proline	55-62	HtrA serine peptidase 1	Homo sapiens	103-108
23963851-6	2013	Three-dimensional models showed that the change from proline to leucine (p.P285L) could attenuate the hydrogen bond between S284 and S287 residues, which might affect function of serine protease HTRA1.	Proline	53-60	HtrA serine peptidase 1	Homo sapiens	195-200
25866551-3	2013	This review is focused on the reported activities and significance of AR phosphorylation, with particular emphasis on proline-directed serine/threonine phosphorylation that occurs predominantly on the receptor.	Proline	118-125	androgen receptor	Homo sapiens	70-72
23985323-4	2013	We identify the SH3 domains of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2.	Proline	73-80	nebulin	Homo sapiens	31-38
23985323-4	2013	We identify the SH3 domains of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2.	Proline	73-80	xin actin binding repeat containing 1	Homo sapiens	97-100
23985323-4	2013	We identify the SH3 domains of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2.	Proline	73-80	xin actin binding repeat containing 2	Homo sapiens	105-110
22549912-1	2013	Pin1 is a unique regulator that catalyzes the conversion of a specific phospho-Ser/Thr-Pro-containing motif in target proteins.	Proline	87-90	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
23824909-2	2013	BAG3 carries a BAG domain, a WW domain, and a proline-rich repeat (PXXP), all of which mediate binding to different partners.	Proline	46-53	BAG cochaperone 3	Homo sapiens	0-4
23860773-0	2013	P53 codon 72 Arg/Pro polymorphism and glioma risk: an updated meta-analysis.	Proline	17-20	tumor protein p53	Homo sapiens	0-3
23812725-0	2013	P53 codon 72 Arg/Pro polymorphism and lung cancer risk in Asians: an updated meta-analysis.	Proline	17-20	tumor protein p53	Homo sapiens	0-3
23812725-1	2013	The polymorphism of p53 codon 72, a transversion of G to C (Arg to Pro), has been demonstrated to be associated with the risk for lung cancer.	Proline	67-70	tumor protein p53	Homo sapiens	20-23
23878394-4	2013	We report here that FOXC2 is phosphorylated on eight evolutionarily conserved proline-directed serine/threonine residues.	Proline	78-85	forkhead box C2	Homo sapiens	20-25
23887939-3	2013	The N-terminal of the GR contains numerous potential proline-directed phosphorylation sites, some of which can regulate GR transactivation.	Proline	53-60	nuclear receptor subfamily 3 group C member 1	Homo sapiens	22-24
23887939-3	2013	The N-terminal of the GR contains numerous potential proline-directed phosphorylation sites, some of which can regulate GR transactivation.	Proline	53-60	nuclear receptor subfamily 3 group C member 1	Homo sapiens	120-122
23887939-4	2013	Unrestricted proline isomerisation can be inhibited by adjacent serine phosphorylation and requires a prolyl isomerise, Pin1.	Proline	13-20	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	120-124
23887939-5	2013	Pin1 therefore determines the functional outcome of proline-directed kinases acting on the GR, as cis/trans isomers are distinct pools with different interacting proteins.	Proline	52-59	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
23887939-5	2013	Pin1 therefore determines the functional outcome of proline-directed kinases acting on the GR, as cis/trans isomers are distinct pools with different interacting proteins.	Proline	52-59	nuclear receptor subfamily 3 group C member 1	Homo sapiens	91-93
23715779-9	2013	Concerning the histological types of lung cancer, the p53 codon 72 variant exerts risk effect on the lung carcinogenesis in patients with adenocarcinoma (OR Arg/Pro vs. Arg/Arg = 1.10, 95 % CI = 1.00-1.22, P OR = 0.048).	Proline	161-164	tumor protein p53	Homo sapiens	54-57
23715779-10	2013	Additionally, subgroup analysis by the smoking status demonstrated that the p53 codon 72 variant seemed to play a protective role in lung carcinogenesis among the non-smokers but not the smokers in the contrast model of Arg/Pro vs. Arg/Arg (OR Arg/Pro vs. Arg/Arg = 0.71, 95 % CI = 0.50-1.00, P OR = 0.049).	Proline	224-227	tumor protein p53	Homo sapiens	76-79
23812725-3	2013	Thus, we performed a meta-analysis by pooling all currently available case-control studies to estimate the effect of p53 codon 72 Arg/Pro polymorphism on the development of lung cancer.	Proline	134-137	tumor protein p53	Homo sapiens	117-120
23812725-10	2013	The updated meta-analysis suggests that the p53 codon 72 Arg/Pro polymorphism is a risk factor for lung cancer in the Asian population.	Proline	61-64	tumor protein p53	Homo sapiens	44-47
23860773-1	2013	P53 codon 72 Arg/Pro is a C/G variation upstream of the p53 gene on human chromosome 17p13.	Proline	17-20	tumor protein p53	Homo sapiens	0-3
23860773-10	2013	The relationship of p53 codon 72 Arg/Pro polymorphism with the susceptibility to glioma needs further estimation by more individual studies with high quality across ethnicities.	Proline	37-40	tumor protein p53	Homo sapiens	20-23
23860773-1	2013	P53 codon 72 Arg/Pro is a C/G variation upstream of the p53 gene on human chromosome 17p13.	Proline	17-20	tumor protein p53	Homo sapiens	56-59
23860773-9	2013	Our study suggests that the polymorphism of p53 codon 72 Arg/Pro may play a protective role in the development of glioblastoma.	Proline	61-64	tumor protein p53	Homo sapiens	44-47
24098653-7	2013	In all previously reported crystal structures, the peptide bound to the Grb2 SH2 domains adopts a type-I beta-turn conformation, except those with a proline residue at the pY+3 position.	Proline	149-156	growth factor receptor bound protein 2	Homo sapiens	72-76
23912193-2	2013	The modification occurs through post-translational hydroxylation at 4-position of proline residues some of which are followed by O-glycosylation at the resulting Hyp which is also found in some secreted peptide hormones such as CLAVATA3 (CLV3) of Arabidopsis thaliana plants.	Proline	82-89	CLAVATA3	Arabidopsis thaliana	228-236
24078097-6	2013	Through comparing the results of seed germination, root growth, stomatal aperture, water loss, and proline accumulation between the Atgalk2 mutants and Col-0, it was found that Atgalk2 mutants showed less sensitive to ABA than Col-0.	Proline	99-106	GHMP kinase family protein	Arabidopsis thaliana	177-184
23912193-2	2013	The modification occurs through post-translational hydroxylation at 4-position of proline residues some of which are followed by O-glycosylation at the resulting Hyp which is also found in some secreted peptide hormones such as CLAVATA3 (CLV3) of Arabidopsis thaliana plants.	Proline	82-89	CLAVATA3	Arabidopsis thaliana	238-242
23952496-6	2013	NO treatment significantly enhanced the accumulation of total phenolics and proline, which resulted from the increased activities of phenylalanine ammonia-lyase and Delta1-pyrroline-5-carboxylate synthetase and decreased proline dehydrogenase activity.	Proline	76-83	delta-1-pyrroline-5-carboxylate synthase	Musa acuminata	171-206
23581681-10	2013	FUTURE DIRECTIONS: New evidence suggests that proline biosynthesis enzymes interact with redox proteins such as thioredoxin.	Proline	46-53	thioredoxin	Homo sapiens	112-123
23886708-0	2013	In silico investigation of PHD-3 specific HIF1-alpha proline 567 hydroxylation: a new player in the VHL/HIF-1alpha interaction pathway?	Proline	53-60	egl-9 family hypoxia inducible factor 3	Homo sapiens	27-32
24051604-1	2013	The proline repeat motif (PxxP) of Nef is required for interaction with the SH3 domains of macrophage-specific Src kinase Hck.	Proline	4-11	S100 calcium binding protein B	Homo sapiens	35-38
24051604-1	2013	The proline repeat motif (PxxP) of Nef is required for interaction with the SH3 domains of macrophage-specific Src kinase Hck.	Proline	4-11	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	122-125
24051604-3	2013	Experiments in HIV-1 infected macrophages confirmed the presence of a Nef:Hck complex which was dependent on the Nef proline repeat motif.	Proline	117-124	Nef	Human immunodeficiency virus 1	70-73
24051604-3	2013	Experiments in HIV-1 infected macrophages confirmed the presence of a Nef:Hck complex which was dependent on the Nef proline repeat motif.	Proline	117-124	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
24051604-3	2013	Experiments in HIV-1 infected macrophages confirmed the presence of a Nef:Hck complex which was dependent on the Nef proline repeat motif.	Proline	117-124	Nef	Human immunodeficiency virus 1	113-116
24051604-4	2013	The proline repeat motif of Nef also enhanced both HIV-1 infection and replication in macrophages, and was required for incorporation of Hck into viral particles.	Proline	4-11	Nef	Human immunodeficiency virus 1	28-31
24051604-4	2013	The proline repeat motif of Nef also enhanced both HIV-1 infection and replication in macrophages, and was required for incorporation of Hck into viral particles.	Proline	4-11	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	137-140
24052813-4	2013	We show that the TCP domain of CPAP constitutes a novel proline recognition domain that forms a 1:1 complex with a short, highly conserved target motif in STIL.	Proline	56-63	centromere protein J	Homo sapiens	31-35
24052813-4	2013	We show that the TCP domain of CPAP constitutes a novel proline recognition domain that forms a 1:1 complex with a short, highly conserved target motif in STIL.	Proline	56-63	STIL centriolar assembly protein	Homo sapiens	155-159
23886708-0	2013	In silico investigation of PHD-3 specific HIF1-alpha proline 567 hydroxylation: a new player in the VHL/HIF-1alpha interaction pathway?	Proline	53-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-52
23892081-3	2013	Here, we report that Atx7 specifically interacts with the third SH3 domain (SH3C) of R85FL through its second portion of proline-rich region (PRR).	Proline	121-128	ataxin 7	Homo sapiens	21-25
23886708-2	2013	This mechanism is mediated through hydroxylation of HIF-1alpha proline 564, although in vitro tests have previously shown an alternative hydroxylation at proline 567 by PHD-3.	Proline	63-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
23892081-3	2013	Here, we report that Atx7 specifically interacts with the third SH3 domain (SH3C) of R85FL through its second portion of proline-rich region (PRR).	Proline	121-128	sorbin and SH3 domain containing 1	Homo sapiens	85-90
23886708-2	2013	This mechanism is mediated through hydroxylation of HIF-1alpha proline 564, although in vitro tests have previously shown an alternative hydroxylation at proline 567 by PHD-3.	Proline	154-161	egl-9 family hypoxia inducible factor 3	Homo sapiens	169-174
23851158-8	2013	In particular, metabolites associated with arginine and proline metabolism, and glycerolipid metabolism, were markedly different between genotypes suggesting a constitutive role for PPARbeta/delta in the metabolism of these amino acids.	Proline	56-63	peroxisome proliferator activator receptor delta	Mus musculus	182-190
24069399-4	2013	Here we show that ALG-2/Ca(2+) is capable of attenuating vesicle budding in vitro through interaction with an ALG-2 binding domain in the proline rich region of Sec31A.	Proline	138-145	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	18-23
24069399-4	2013	Here we show that ALG-2/Ca(2+) is capable of attenuating vesicle budding in vitro through interaction with an ALG-2 binding domain in the proline rich region of Sec31A.	Proline	138-145	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	110-115
24069399-4	2013	Here we show that ALG-2/Ca(2+) is capable of attenuating vesicle budding in vitro through interaction with an ALG-2 binding domain in the proline rich region of Sec31A.	Proline	138-145	SEC31 homolog A, COPII coat complex component	Homo sapiens	161-167
24039833-1	2013	Stimulation of the OSR1 (Oxidative stress-responsive kinase-1)/SPAK [STE20 (sterile 20)/SPS1-related proline/alanine-rich kinase]-NCC (Na(+)-Cl(-) cotransporter) signaling cascade plays an important role in the WNK [With-No-Lysine (K)] kinase 4 D561A knock-in mouse model of pseudohypoaldosteronism type II (PHA II) characterized by salt-sensitive hypertension and hyperkalemia.	Proline	101-108	odd-skipped related transcription factor 1	Mus musculus	19-23
24039833-1	2013	Stimulation of the OSR1 (Oxidative stress-responsive kinase-1)/SPAK [STE20 (sterile 20)/SPS1-related proline/alanine-rich kinase]-NCC (Na(+)-Cl(-) cotransporter) signaling cascade plays an important role in the WNK [With-No-Lysine (K)] kinase 4 D561A knock-in mouse model of pseudohypoaldosteronism type II (PHA II) characterized by salt-sensitive hypertension and hyperkalemia.	Proline	101-108	serine/threonine kinase 39	Mus musculus	63-67
24039833-1	2013	Stimulation of the OSR1 (Oxidative stress-responsive kinase-1)/SPAK [STE20 (sterile 20)/SPS1-related proline/alanine-rich kinase]-NCC (Na(+)-Cl(-) cotransporter) signaling cascade plays an important role in the WNK [With-No-Lysine (K)] kinase 4 D561A knock-in mouse model of pseudohypoaldosteronism type II (PHA II) characterized by salt-sensitive hypertension and hyperkalemia.	Proline	101-108	serine/threonine kinase 24	Mus musculus	69-74
23897807-5	2013	To confirm PTP-PEST interaction with SKAP-Hom, in vitro pull down assays were performed demonstrating that the PTP catalytic domain and Proline-rich 1 (P1) domain are respectively binding to the SKAP-Hom Y260 and Y297 residues and its SH3 domain.	Proline	136-143	protein tyrosine phosphatase, non-receptor type 12	Mus musculus	11-19
24039956-3	2013	Additionally, the C. parasitica Prodh and P5Cdh genes were able to complement the Saccharomyces cerevisiae put1 and put2 null mutants, respectively, to allow these proline auxotrophic yeast mutants to grow on media with proline as the sole source of nitrogen.	Proline	164-171	proline dehydrogenase	Saccharomyces cerevisiae S288C	107-111
24039956-3	2013	Additionally, the C. parasitica Prodh and P5Cdh genes were able to complement the Saccharomyces cerevisiae put1 and put2 null mutants, respectively, to allow these proline auxotrophic yeast mutants to grow on media with proline as the sole source of nitrogen.	Proline	164-171	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	116-120
24039956-3	2013	Additionally, the C. parasitica Prodh and P5Cdh genes were able to complement the Saccharomyces cerevisiae put1 and put2 null mutants, respectively, to allow these proline auxotrophic yeast mutants to grow on media with proline as the sole source of nitrogen.	Proline	220-227	proline dehydrogenase	Saccharomyces cerevisiae S288C	107-111
24039956-3	2013	Additionally, the C. parasitica Prodh and P5Cdh genes were able to complement the Saccharomyces cerevisiae put1 and put2 null mutants, respectively, to allow these proline auxotrophic yeast mutants to grow on media with proline as the sole source of nitrogen.	Proline	220-227	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	116-120
23888048-0	2013	Structure and activity of the peptidyl-prolyl isomerase domain from the histone chaperone Fpr4 toward histone H3 proline isomerization.	Proline	113-120	peptidylprolyl isomerase FPR4	Saccharomyces cerevisiae S288C	90-94
23897807-5	2013	To confirm PTP-PEST interaction with SKAP-Hom, in vitro pull down assays were performed demonstrating that the PTP catalytic domain and Proline-rich 1 (P1) domain are respectively binding to the SKAP-Hom Y260 and Y297 residues and its SH3 domain.	Proline	136-143	src family associated phosphoprotein 2	Mus musculus	37-45
23888048-2	2013	As one of four FKBPs within the yeast Saccharomyces cerevisiae, Fpr4 has been described as a histone chaperone, and is in addition implicated in epigenetic function in part due to its mediation of cis-trans conversion of proline residues within histone tails.	Proline	221-228	peptidylprolyl isomerase FPR4	Saccharomyces cerevisiae S288C	64-68
23888048-5	2013	Observation of the uncatalyzed and Fpr4-catalyzed isomerization rates at equilibrium demonstrate Pro(16) and Pro(30) of histone H3 as the major proline targets of Fpr4, with little activity shown against Pro(38).	Proline	97-100	peptidylprolyl isomerase FPR4	Saccharomyces cerevisiae S288C	35-39
23888048-5	2013	Observation of the uncatalyzed and Fpr4-catalyzed isomerization rates at equilibrium demonstrate Pro(16) and Pro(30) of histone H3 as the major proline targets of Fpr4, with little activity shown against Pro(38).	Proline	109-112	peptidylprolyl isomerase FPR4	Saccharomyces cerevisiae S288C	35-39
23888048-5	2013	Observation of the uncatalyzed and Fpr4-catalyzed isomerization rates at equilibrium demonstrate Pro(16) and Pro(30) of histone H3 as the major proline targets of Fpr4, with little activity shown against Pro(38).	Proline	144-151	peptidylprolyl isomerase FPR4	Saccharomyces cerevisiae S288C	35-39
23888048-5	2013	Observation of the uncatalyzed and Fpr4-catalyzed isomerization rates at equilibrium demonstrate Pro(16) and Pro(30) of histone H3 as the major proline targets of Fpr4, with little activity shown against Pro(38).	Proline	144-151	peptidylprolyl isomerase FPR4	Saccharomyces cerevisiae S288C	163-167
23939045-9	2013	The epitope for a third mAb, MANSMA3, has been located to eight amino-acids in the proline-rich domain of SMN.	Proline	83-90	survival of motor neuron 1, telomeric	Homo sapiens	106-109
23897807-5	2013	To confirm PTP-PEST interaction with SKAP-Hom, in vitro pull down assays were performed demonstrating that the PTP catalytic domain and Proline-rich 1 (P1) domain are respectively binding to the SKAP-Hom Y260 and Y297 residues and its SH3 domain.	Proline	136-143	protein tyrosine phosphatase, receptor type, U	Mus musculus	11-14
23897807-5	2013	To confirm PTP-PEST interaction with SKAP-Hom, in vitro pull down assays were performed demonstrating that the PTP catalytic domain and Proline-rich 1 (P1) domain are respectively binding to the SKAP-Hom Y260 and Y297 residues and its SH3 domain.	Proline	136-143	src family associated phosphoprotein 2	Mus musculus	195-203
23897820-6	2013	Although similar decreases in mRNA levels were observed of the proline-rich anchor of AChE, PRiMA, no changes were seen in mRNA levels of the related enzyme, butyryl-cholinesterase, nor of the high-affinity choline transporter.	Proline	63-70	acetylcholinesterase	Mus musculus	86-90
23335000-2	2013	Some ATXN2 associates with receptor tyrosine kinases (RTK), inhibiting their endocytic internalization through interaction of proline-rich domains (PRD) in ATXN2 with SH3 motifs in Src.	Proline	126-133	ataxin 2	Mus musculus	5-10
24010666-0	2013	Effect of proline mutations on the monomer conformations of amylin.	Proline	10-17	islet amyloid polypeptide	Homo sapiens	60-66
24010666-3	2013	Pramlintide is a synthetic analog of human amylin that shares three proline substitutions with rat amylin.	Proline	68-75	islet amyloid polypeptide	Homo sapiens	43-49
24010666-6	2013	However, the detailed effects of these proline substitutions on full-length hIAPP remain poorly understood.	Proline	39-46	islet amyloid polypeptide	Homo sapiens	76-81
24010666-7	2013	In this work, we use molecular simulations and bias-exchange metadynamics to investigate the effect of proline substitutions on the conformation of the hIAPP monomer.	Proline	103-110	islet amyloid polypeptide	Homo sapiens	152-157
23483183-9	2013	RESULTS: The distribution of Arg/Arg, Arg/Pro, and Pro/Pro genotypes of codon 72 of TP53 gene was: 63.3, 34.7, and 2.0 % in the cervical carcinomas and 58.1, 33.8, and 8.1 % in the control group.	Proline	42-45	tumor protein p53	Homo sapiens	84-88
24019961-2	2013	We previously reported that the proline 72 polymorphic variant of p53 (P72) demonstrates increased ability to transactivate a subset of genes, relative to arginine 72 (R72); one of these genes is macrophage colony stimulating factor (CSF1).	Proline	32-39	tumor protein p53	Homo sapiens	66-69
24019961-2	2013	We previously reported that the proline 72 polymorphic variant of p53 (P72) demonstrates increased ability to transactivate a subset of genes, relative to arginine 72 (R72); one of these genes is macrophage colony stimulating factor (CSF1).	Proline	32-39	DEAD-box helicase 17	Homo sapiens	71-74
24019961-2	2013	We previously reported that the proline 72 polymorphic variant of p53 (P72) demonstrates increased ability to transactivate a subset of genes, relative to arginine 72 (R72); one of these genes is macrophage colony stimulating factor (CSF1).	Proline	32-39	colony stimulating factor 1	Homo sapiens	234-238
23766104-5	2013	We discovered two patients who harbored a heterozygous c.1702C&gt;T variant in FOXP1 that predicted a potentially deleterious substitution of a highly conserved proline (p.Pro568Ser).	Proline	161-168	forkhead box P1	Homo sapiens	79-84
23280577-1	2013	Pin1 is a unique enzyme that can isomerize specific phospho-Ser/Thr-Pro peptide bonds, inducing a conformational change in the target protein.	Proline	68-71	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
23335000-2	2013	Some ATXN2 associates with receptor tyrosine kinases (RTK), inhibiting their endocytic internalization through interaction of proline-rich domains (PRD) in ATXN2 with SH3 motifs in Src.	Proline	126-133	ataxin 2	Mus musculus	156-161
23335000-2	2013	Some ATXN2 associates with receptor tyrosine kinases (RTK), inhibiting their endocytic internalization through interaction of proline-rich domains (PRD) in ATXN2 with SH3 motifs in Src.	Proline	126-133	sperm hammerhead 3	Mus musculus	167-170
23335000-2	2013	Some ATXN2 associates with receptor tyrosine kinases (RTK), inhibiting their endocytic internalization through interaction of proline-rich domains (PRD) in ATXN2 with SH3 motifs in Src.	Proline	126-133	Rous sarcoma oncogene	Mus musculus	181-184
23867359-1	2013	Metchnikowin is a proline-rich peptide from Drosophila with antibacterial and antifungal activities.	Proline	18-25	Metchnikowin	Drosophila melanogaster	0-12
23867359-6	2013	Active metchnikowin was released by cleavage of the Asp-Pro bond between fused proteins by 72-h formic acid hydrolysis at 50 C. After 24-h dialysis, metchnikowin was purified to electrophoretic homogeneity and showed significant antibacterial activities against both Bacillus subtilis and E. coli DH5alpha.	Proline	56-59	Metchnikowin	Drosophila melanogaster	7-19
23853094-4	2013	The primary structure of Foxp3 contains four cyclin-dependent kinase (CDK) motifs (Ser/Thr-Pro) within the N-terminal repressor domain, and we show that CDK2 can partner with cyclin E to phosphorylate Foxp3 at these sites.	Proline	91-94	forkhead box P3	Homo sapiens	25-30
23891840-5	2013	A proline-rich sequence in the flagpole is unique to Rlf and several proteins that interact with this sequence by SH3 domains are identified.	Proline	2-9	RLF zinc finger	Homo sapiens	53-56
23932902-6	2013	Cep192 is hydroxylated by PHD1 on proline residue 1717.	Proline	34-41	centrosomal protein 192	Homo sapiens	0-6
23932902-6	2013	Cep192 is hydroxylated by PHD1 on proline residue 1717.	Proline	34-41	egl-9 family hypoxia inducible factor 2	Homo sapiens	26-30
23707382-8	2013	The data establish a new view of SR protein regulation in which SRPK1 and CLK1 partition activities based on Ser-Pro versus Arg-Ser placement rather than on N- and C-terminal preferences along the RS domain.	Proline	113-116	RNA binding protein with serine rich domain 1	Homo sapiens	33-43
23987507-3	2013	(2013) show that PHD1 can act as such a sensor through proline hydroxylation of the centrosomal protein Cep192.	Proline	55-62	egl-9 family hypoxia inducible factor 2	Homo sapiens	17-21
23987507-3	2013	(2013) show that PHD1 can act as such a sensor through proline hydroxylation of the centrosomal protein Cep192.	Proline	55-62	centrosomal protein 192	Homo sapiens	104-110
23853094-4	2013	The primary structure of Foxp3 contains four cyclin-dependent kinase (CDK) motifs (Ser/Thr-Pro) within the N-terminal repressor domain, and we show that CDK2 can partner with cyclin E to phosphorylate Foxp3 at these sites.	Proline	91-94	cyclin dependent kinase 2	Homo sapiens	153-157
23707382-8	2013	The data establish a new view of SR protein regulation in which SRPK1 and CLK1 partition activities based on Ser-Pro versus Arg-Ser placement rather than on N- and C-terminal preferences along the RS domain.	Proline	113-116	SRSF protein kinase 1	Homo sapiens	64-69
23707382-8	2013	The data establish a new view of SR protein regulation in which SRPK1 and CLK1 partition activities based on Ser-Pro versus Arg-Ser placement rather than on N- and C-terminal preferences along the RS domain.	Proline	113-116	CDC like kinase 1	Homo sapiens	74-78
23830461-5	2013	An ELP consists of the repeating pentapeptide of specific amino acids, Val-Pro-Gly-Xaa-Gly (where the "guest residue" Xaa is any amino except proline) that undergoes a reversible phase transition at a specific temperature (transition temperature, Tt).	Proline	142-149	nuclear receptor subfamily 5 group A member 1	Homo sapiens	3-6
23848432-4	2013	Pim1 recognizes peptide substrates of the consensus RXR(H/R)X(S/T); it accepts essentially any amino acid at the S/T-2 and S/T+1 positions, but strongly disfavors acidic residues (Asp or Glu) at the S/T-2 position and a proline residue at the S/T+1 position.	Proline	220-227	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
23157676-1	2013	Proline-directed protein phosphorylation (pSer/Thr-Pro), a central signaling mechanism in diverse cellular processes in physiology and disease, has been proposed to be subject to further cis-trans conformational regulation by the unique prolyl isomerase Pin1.	Proline	0-7	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	254-258
23586710-2	2013	The interaction between the SH3 domain of CIP85 and a proline-rich region of Cx43 has previously been associated with an increased rate of Cx43 turnover through lysosomal mechanisms.	Proline	54-61	small G protein signaling modulator 3	Homo sapiens	42-47
23586710-2	2013	The interaction between the SH3 domain of CIP85 and a proline-rich region of Cx43 has previously been associated with an increased rate of Cx43 turnover through lysosomal mechanisms.	Proline	54-61	gap junction protein alpha 1	Homo sapiens	77-81
23586710-2	2013	The interaction between the SH3 domain of CIP85 and a proline-rich region of Cx43 has previously been associated with an increased rate of Cx43 turnover through lysosomal mechanisms.	Proline	54-61	gap junction protein alpha 1	Homo sapiens	139-143
23553128-5	2013	Serum prolidase assay is based on a colorimetric determination of proline by Chinard"s reagent.	Proline	66-73	peptidase D	Homo sapiens	6-15
23720732-9	2013	We further demonstrate that the VP1054 protein specifically recognizes these GGN-rich islands, which at the same time encode crucial proline-rich domains in p78/83, an essential gene adjacent to the polyhedrin gene in the AcMNPV genome.	Proline	133-140	gametogenetin	Homo sapiens	77-80
23685128-9	2013	In conclusion, these data suggest that HF interferes with proline incorporation or uptake, resulting in apoptosis via amino acid starvation response in T cells in the response to antigen/mitogen or IL-2 stimulation.	Proline	58-65	interleukin 2	Mus musculus	198-202
24137204-3	2013	The aim of this meta-analysis was to derive a more precise estimation of the correlation between a common polymorphism [proline (Pro) 919 serine (Ser); rs4986764 C&gt;T] in the BACH1 gene and susceptibility to breast cancer.	Proline	120-127	BRCA1 interacting helicase 1	Homo sapiens	177-182
24137204-3	2013	The aim of this meta-analysis was to derive a more precise estimation of the correlation between a common polymorphism [proline (Pro) 919 serine (Ser); rs4986764 C&gt;T] in the BACH1 gene and susceptibility to breast cancer.	Proline	129-132	BRCA1 interacting helicase 1	Homo sapiens	177-182
23936226-0	2013	Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.	Proline	50-57	intersectin 1	Homo sapiens	17-28
23683469-5	2013	The p53 gene contains a single nucleotide polymorphism at codon 72 of exon 4 which encodes either proline (Pro) or arginine (Arg).	Proline	98-105	tumor protein p53	Homo sapiens	4-7
23683469-5	2013	The p53 gene contains a single nucleotide polymorphism at codon 72 of exon 4 which encodes either proline (Pro) or arginine (Arg).	Proline	107-110	tumor protein p53	Homo sapiens	4-7
23908769-5	2013	Nerve terminals in which dynamin 1 and 3 have been replaced with dynamin 1 harboring dephospho- or phospho-mimetic mutations in the proline-rich domain eliminate the acceleration phase by either setting endocytosis at an accelerated state or a decelerated state, respectively.	Proline	132-139	dynamin 1	Homo sapiens	25-40
23775083-9	2013	Ca(2+) binding drives Pro-250, at the base of an IgE-binding loop (loop 4), from the trans to the cis configuration with a concomitant conformational change and ordering of residues in the loop.	Proline	22-25	immunoglobulin heavy constant epsilon	Homo sapiens	49-52
23708493-2	2013	Nanog is phosphorylated at multiple Ser/Thr-Pro motifs, which promotes the interaction between Nanog and the prolyl isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination.	Proline	44-47	Nanog homeobox	Homo sapiens	0-5
23708493-2	2013	Nanog is phosphorylated at multiple Ser/Thr-Pro motifs, which promotes the interaction between Nanog and the prolyl isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination.	Proline	44-47	Nanog homeobox	Homo sapiens	95-100
23708493-2	2013	Nanog is phosphorylated at multiple Ser/Thr-Pro motifs, which promotes the interaction between Nanog and the prolyl isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination.	Proline	44-47	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	126-130
23708493-2	2013	Nanog is phosphorylated at multiple Ser/Thr-Pro motifs, which promotes the interaction between Nanog and the prolyl isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination.	Proline	44-47	Nanog homeobox	Homo sapiens	95-100
23887657-2	2013	The proline-encoding (Pro-) allele of this SNP has been associated with an increased breast cancer risk, which has been attributed to the elevated secretion of this TGFbeta1 variant observed in vitro and in male subjects.	Proline	4-11	transforming growth factor beta 1	Homo sapiens	165-173
23870269-1	2013	WASp-interacting protein (WIP) is a 503-residue proline-rich polypeptide expressed in human T cells.	Proline	48-55	WAS/WASL interacting protein family member 1	Homo sapiens	0-24
23894476-9	2013	In addition, when Saccharomyces cerevisiae null mutants for this gene (PUT1) were complemented with the TcPRODH gene, diminished free intracellular proline levels and an enhanced sensitivity to oxidative stress in comparison to the null mutant were observed, supporting the hypothesis that free proline accumulation constitutes a defense against oxidative imbalance.	Proline	148-155	proline dehydrogenase	Saccharomyces cerevisiae S288C	71-75
23894476-9	2013	In addition, when Saccharomyces cerevisiae null mutants for this gene (PUT1) were complemented with the TcPRODH gene, diminished free intracellular proline levels and an enhanced sensitivity to oxidative stress in comparison to the null mutant were observed, supporting the hypothesis that free proline accumulation constitutes a defense against oxidative imbalance.	Proline	295-302	proline dehydrogenase	Saccharomyces cerevisiae S288C	71-75
23894642-5	2013	Instead, the major functions of the AAK domain appear to be providing a binding site for the allosteric activator, L-arginine, and an N-terminal proline-rich motif that is likely to function in signal transduction to CPS1.	Proline	145-152	carbamoyl-phosphate synthase 1	Homo sapiens	217-221
23870269-1	2013	WASp-interacting protein (WIP) is a 503-residue proline-rich polypeptide expressed in human T cells.	Proline	48-55	WAS/WASL interacting protein family member 1	Homo sapiens	26-29
23637126-1	2013	Dipeptidylpeptidase (DPP) 4 has the potential to truncate proteins with a penultimate alanine, proline, or other selective amino acids at the N-terminus.	Proline	95-102	dipeptidyl peptidase 4	Homo sapiens	0-27
23818613-0	2013	Structural and functional analysis of the yeast N-acetyltransferase Mpr1 involved in oxidative stress tolerance via proline metabolism.	Proline	116-123	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	68-72
23818613-1	2013	Mpr1 (sigma1278b gene for proline-analog resistance 1), which was originally isolated as N-acetyltransferase detoxifying the proline analog L-azetidine-2-carboxylate, protects yeast cells from various oxidative stresses.	Proline	26-33	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	0-4
23818613-1	2013	Mpr1 (sigma1278b gene for proline-analog resistance 1), which was originally isolated as N-acetyltransferase detoxifying the proline analog L-azetidine-2-carboxylate, protects yeast cells from various oxidative stresses.	Proline	125-132	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	0-4
23818613-2	2013	Mpr1 mediates the L-proline and L-arginine metabolism by acetylating L-Delta(1)-pyrroline-5-carboxylate, leading to the L-arginine-dependent production of nitric oxide, which confers oxidative stress tolerance.	Proline	18-27	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	0-4
23769667-4	2013	This was supported by complete loss of RF1 catalytic activity when glutamine is replaced by proline, the only residue that lacks a backbone NH group.	Proline	92-99	mitochondrial translation release factor 1	Homo sapiens	39-42
23770366-3	2013	The multi-domain structure of motopsin, consisting of a signal peptide, a proline-rich domain, a kringle domain, three scavenger receptor cysteine-rich domains, and a protease domain at the C-terminal, suggests the interaction with other molecules through these domains.	Proline	74-81	protease, serine 12 neurotrypsin (motopsin)	Mus musculus	30-38
23770366-4	2013	To identify a protein interacting with motopsin, we performed yeast two-hybrid screening and found that seizure-related gene 6 (sez-6), a transmembrane protein on the plasma membrane of neuronal cells, bound to the proline-rich/kringle domain of motopsin.	Proline	215-222	protease, serine 12 neurotrypsin (motopsin)	Mus musculus	39-47
23770366-4	2013	To identify a protein interacting with motopsin, we performed yeast two-hybrid screening and found that seizure-related gene 6 (sez-6), a transmembrane protein on the plasma membrane of neuronal cells, bound to the proline-rich/kringle domain of motopsin.	Proline	215-222	seizure related gene 6	Mus musculus	104-126
23770366-4	2013	To identify a protein interacting with motopsin, we performed yeast two-hybrid screening and found that seizure-related gene 6 (sez-6), a transmembrane protein on the plasma membrane of neuronal cells, bound to the proline-rich/kringle domain of motopsin.	Proline	215-222	seizure related gene 6	Mus musculus	128-133
23770366-4	2013	To identify a protein interacting with motopsin, we performed yeast two-hybrid screening and found that seizure-related gene 6 (sez-6), a transmembrane protein on the plasma membrane of neuronal cells, bound to the proline-rich/kringle domain of motopsin.	Proline	215-222	protease, serine 12 neurotrypsin (motopsin)	Mus musculus	246-254
23770367-3	2013	The molecular interaction involves the tyrosine residue 33 of WOX1 and the proline-rich motifs of LMP2A.	Proline	75-82	WW domain containing oxidoreductase	Homo sapiens	62-66
23770367-3	2013	The molecular interaction involves the tyrosine residue 33 of WOX1 and the proline-rich motifs of LMP2A.	Proline	75-82	LMP2A	Human gammaherpesvirus 4	98-103
23826856-7	2013	Association mapping revealed that a single nucleotide change from cytosine (C) to thymine (T) in the ZmIPT2 coding region, which converted a proline residue into a serine residue, was significantly associated with hundred kernel weight (HKW) in three environments (P &lt;0.05), and explained 4.76% of the total phenotypic variation.	Proline	141-148	adenylate isopentenyltransferase 5, chloroplastic	Zea mays	101-107
23861868-4	2013	A highly-conserved central segment within classic MBP consists of a proline-rich region (murine 18.5-kDa sequence -T92-P93-R94-T95-P96-P97-P98-S99-) containing a putative SH3-ligand, adjacent to a region that forms an amphipathic alpha-helix (P82-I90) upon interaction with membranes, or under membrane-mimetic conditions.	Proline	68-75	myelin basic protein	Mus musculus	50-53
23861960-1	2013	The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation.	Proline	117-124	tumor protein p53	Homo sapiens	21-24
23861960-1	2013	The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation.	Proline	117-124	proline dehydrogenase 1	Homo sapiens	92-97
23861960-1	2013	The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation.	Proline	117-124	proline dehydrogenase 1	Homo sapiens	140-145
23861960-11	2013	This supports a deeper link between proteins of the p53-family and metabolic pathways, as PRODH modulates the balance of proline and glutamate levels and those of their derivative alpha-keto-glutarate (alpha-KG) under normal and pathological (tumor) conditions.	Proline	121-128	tumor protein p53	Homo sapiens	52-55
23861960-11	2013	This supports a deeper link between proteins of the p53-family and metabolic pathways, as PRODH modulates the balance of proline and glutamate levels and those of their derivative alpha-keto-glutarate (alpha-KG) under normal and pathological (tumor) conditions.	Proline	121-128	proline dehydrogenase 1	Homo sapiens	90-95
23696640-8	2013	Thus, the contacts mediated by Pro-30 in wild-type AHSP promote alphaHb autooxidation by introducing strain into the proximal heme pocket.	Proline	31-34	alpha hemoglobin stabilizing protein	Homo sapiens	51-55
23699396-4	2013	Yeast two-hybrid and pull-down experiments identify two proline-rich motifs in PakB-1-180 that directly interact with the SH3 domain of Dictyostelium actin-binding protein 1 (dAbp1).	Proline	56-63	Actin binding protein 1	Drosophila melanogaster	175-180
23436431-6	2013	In view of structural as well as functional importance of the Pro-Gly mediated secondary structures, besides biochemical and biological significance of proteins lipidation via myristoylation or palmytoilation, we highlight potential convenience of the unbranched Plm and Pda moieities not only as main-chain N- and C-terminal protecting groups but also to mimic and stabilize specific isolated secondary and supersecondary structural components frequently observed in proteins and polypeptides.	Proline	62-65	FXYD domain containing ion transport regulator 1	Homo sapiens	263-266
23670531-10	2013	Substitution of Arg for Pro in the N-terminal alpha-helix altered net charge and reduced apoC-I affinity for POPC/TO/W interfaces.	Proline	24-27	apolipoprotein C1	Homo sapiens	89-95
23721578-0	2013	Photodegradation of human growth hormone: a novel backbone cleavage between Glu-88 and Pro-89.	Proline	87-90	growth hormone 1	Homo sapiens	26-40
23868210-4	2013	PEGylated Ac-Trp-[Cit(11,18),hArg(24),Lys(25),Asp(31),Pro(34),1-Nal(35)]CGRP(8-37)-NH2, 9, elicits a dose-dependent reduction of intradermal CGRP-induced local blood flow in rodents with an ED50 of 0.52 mg kg(-1) without any overt adverse effects.	Proline	54-57	calcitonin related polypeptide alpha	Homo sapiens	72-76
23663663-0	2013	Multimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*.	Proline	69-76	SH3 domain containing kinase binding protein 1	Homo sapiens	39-44
23663663-0	2013	Multimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*.	Proline	69-76	CD2 associated protein	Homo sapiens	45-50
23663663-0	2013	Multimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*.	Proline	69-76	CD2 molecule	Homo sapiens	45-48
23663663-2	2013	Using NMR, isothermal titration calorimetry and small-angle X-ray scattering methods, we have characterized several binding modes of the N-terminal SH3 domain (SH3A) of CD2AP and CIN85 with two natural atypical proline-rich regions in CD2 (cluster of differentiation 2) and Cbl-b (Casitas B-lineage lymphoma), and compared these data with previous studies and published crystal structures.	Proline	211-218	CD2 associated protein	Homo sapiens	169-174
23663663-2	2013	Using NMR, isothermal titration calorimetry and small-angle X-ray scattering methods, we have characterized several binding modes of the N-terminal SH3 domain (SH3A) of CD2AP and CIN85 with two natural atypical proline-rich regions in CD2 (cluster of differentiation 2) and Cbl-b (Casitas B-lineage lymphoma), and compared these data with previous studies and published crystal structures.	Proline	211-218	SH3 domain containing kinase binding protein 1	Homo sapiens	179-184
23663663-2	2013	Using NMR, isothermal titration calorimetry and small-angle X-ray scattering methods, we have characterized several binding modes of the N-terminal SH3 domain (SH3A) of CD2AP and CIN85 with two natural atypical proline-rich regions in CD2 (cluster of differentiation 2) and Cbl-b (Casitas B-lineage lymphoma), and compared these data with previous studies and published crystal structures.	Proline	211-218	CD2 molecule	Homo sapiens	169-172
23686112-8	2013	FKBP51 suppression of the mutated rGR did not require FKBP51 peptidylprolyl cis-trans isomerase activity and was not disrupted by mutation of the FK1 proline-rich loop thought to mediate reciprocal FKBP influences on receptor activity.	Proline	150-157	FK506 binding protein 5	Mus musculus	0-6
23686112-8	2013	FKBP51 suppression of the mutated rGR did not require FKBP51 peptidylprolyl cis-trans isomerase activity and was not disrupted by mutation of the FK1 proline-rich loop thought to mediate reciprocal FKBP influences on receptor activity.	Proline	150-157	retinal G protein coupled receptor	Rattus norvegicus	34-37
23743200-3	2013	Among the candidates for DJ-1-partner proteins detected in TOF-MAS analyses of the cellular proteins co-immunoprecipitated with DJ-1, we focused here pyrroline-5-carboxylate reductase 1, PYCR1, a final key enzyme for proline biosynthesis.	Proline	217-224	Parkinsonism associated deglycase	Homo sapiens	25-29
23375628-3	2013	Arginase 1 (Arg1), a marker for the M2 anti-inflammatory subset, hydrolyzes l-arginine into urea and ornithine, a precursor to l-proline and polyamines, which are implicated in tissue repair and wound healing.	Proline	127-136	arginase 1	Homo sapiens	0-10
23375628-3	2013	Arginase 1 (Arg1), a marker for the M2 anti-inflammatory subset, hydrolyzes l-arginine into urea and ornithine, a precursor to l-proline and polyamines, which are implicated in tissue repair and wound healing.	Proline	127-136	arginase 1	Homo sapiens	12-16
23625445-0	2013	Cotton PRP5 gene encoding a proline-rich protein is involved in fiber development.	Proline	28-35	protein PYRICULARIA ORYZAE RESISTANCE 21	Gossypium hirsutum	7-11
23743200-3	2013	Among the candidates for DJ-1-partner proteins detected in TOF-MAS analyses of the cellular proteins co-immunoprecipitated with DJ-1, we focused here pyrroline-5-carboxylate reductase 1, PYCR1, a final key enzyme for proline biosynthesis.	Proline	217-224	pyrroline-5-carboxylate reductase 1	Homo sapiens	150-185
23665563-6	2013	Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL domain to form multivalent interactions with gp78 and UbxD8, which are essential for recruitment of Bag6 to the ER membrane.	Proline	29-36	BAG cochaperone 6	Homo sapiens	13-17
23672495-6	2013	To assess the ability of the model to give insight into the effects of channel mutation we simulated a hERG mutant that contains a Leu to Pro substitution in the voltage sensor S4 helical segment (hERG L532P).	Proline	138-141	ETS transcription factor ERG	Homo sapiens	103-107
23809764-3	2013	Aside from mutation of a catalytic tetrad residue, proline residues at positions 670 and 675 in hAGO1 introduce a kink in the cS7 loop, forming a convex surface within the hAGO1 nucleic-acid-binding channel near the inactive catalytic site.	Proline	51-58	argonaute RISC component 1	Homo sapiens	96-101
23809764-3	2013	Aside from mutation of a catalytic tetrad residue, proline residues at positions 670 and 675 in hAGO1 introduce a kink in the cS7 loop, forming a convex surface within the hAGO1 nucleic-acid-binding channel near the inactive catalytic site.	Proline	51-58	argonaute RISC component 1	Homo sapiens	172-177
23665563-6	2013	Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL domain to form multivalent interactions with gp78 and UbxD8, which are essential for recruitment of Bag6 to the ER membrane.	Proline	29-36	autocrine motility factor receptor	Homo sapiens	189-193
23665563-6	2013	Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL domain to form multivalent interactions with gp78 and UbxD8, which are essential for recruitment of Bag6 to the ER membrane.	Proline	29-36	Fas associated factor family member 2	Homo sapiens	198-203
23665563-6	2013	Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL domain to form multivalent interactions with gp78 and UbxD8, which are essential for recruitment of Bag6 to the ER membrane.	Proline	29-36	BAG cochaperone 6	Homo sapiens	244-248
23665563-6	2013	Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL domain to form multivalent interactions with gp78 and UbxD8, which are essential for recruitment of Bag6 to the ER membrane.	Proline	66-73	BAG cochaperone 6	Homo sapiens	13-17
23665563-6	2013	Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL domain to form multivalent interactions with gp78 and UbxD8, which are essential for recruitment of Bag6 to the ER membrane.	Proline	66-73	autocrine motility factor receptor	Homo sapiens	189-193
23665563-6	2013	Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL domain to form multivalent interactions with gp78 and UbxD8, which are essential for recruitment of Bag6 to the ER membrane.	Proline	66-73	Fas associated factor family member 2	Homo sapiens	198-203
23665563-6	2013	Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL domain to form multivalent interactions with gp78 and UbxD8, which are essential for recruitment of Bag6 to the ER membrane.	Proline	66-73	BAG cochaperone 6	Homo sapiens	244-248
23665563-6	2013	Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL domain to form multivalent interactions with gp78 and UbxD8, which are essential for recruitment of Bag6 to the ER membrane.	Proline	87-94	BAG cochaperone 6	Homo sapiens	13-17
23841028-5	2013	Here we focus our attention on two domains of p140Cap, the TER (Tyrosine Enriched Region) which includes several tyrosine residues, and the CT (Carboxy Terminal) which contains a proline rich sequence, involved in binding to SH2 and SH3 domains, respectively.	Proline	179-186	SRC kinase signaling inhibitor 1	Homo sapiens	46-53
23665563-6	2013	Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL domain to form multivalent interactions with gp78 and UbxD8, which are essential for recruitment of Bag6 to the ER membrane.	Proline	87-94	autocrine motility factor receptor	Homo sapiens	189-193
23665563-6	2013	Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL domain to form multivalent interactions with gp78 and UbxD8, which are essential for recruitment of Bag6 to the ER membrane.	Proline	87-94	Fas associated factor family member 2	Homo sapiens	198-203
23665563-6	2013	Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL domain to form multivalent interactions with gp78 and UbxD8, which are essential for recruitment of Bag6 to the ER membrane.	Proline	87-94	BAG cochaperone 6	Homo sapiens	244-248
23677473-3	2013	DPPIV is a serine protease present in extracellular fluids that cleaves peptides with a proline or alanine in the second position.	Proline	88-95	dipeptidyl peptidase 4	Homo sapiens	0-5
23778187-3	2013	We recently reported that inhibition of prolyl hydroxylase domain protein 2 (PHD2), which hydroxylates the proline residues of hypoxia-inducible factor-alpha (HIF-alpha) and thereby induces HIF-alpha degradation, suppressed inflammatory responses in macrophages.	Proline	107-114	egl-9 family hypoxia-inducible factor 1	Mus musculus	40-75
23778187-3	2013	We recently reported that inhibition of prolyl hydroxylase domain protein 2 (PHD2), which hydroxylates the proline residues of hypoxia-inducible factor-alpha (HIF-alpha) and thereby induces HIF-alpha degradation, suppressed inflammatory responses in macrophages.	Proline	107-114	egl-9 family hypoxia-inducible factor 1	Mus musculus	77-81
23560879-7	2013	Interestingly, a mutant of PRP8 specifically lacking an N-terminal proline-rich region stimulated the splicing of a reporter containing competing branchpoint/3" splice site regions.	Proline	67-74	U4/U6-U5 snRNP complex subunit PRP8	Saccharomyces cerevisiae S288C	27-31
23716654-3	2013	We identified putative disease-causing DNA variants in proline-alanine-rich ste20-related kinase (c.791dup; p.Ser265ValfsX64) and zinc finger protein 408 (ZNF408) (c.1363C&gt;T; p.His455Tyr), the latter of which was also present in an additional Dutch FEVR family that subsequently appeared to share a common ancestor with the original family.	Proline	55-62	zinc finger protein 408	Danio rerio	155-161
23716654-3	2013	We identified putative disease-causing DNA variants in proline-alanine-rich ste20-related kinase (c.791dup; p.Ser265ValfsX64) and zinc finger protein 408 (ZNF408) (c.1363C&gt;T; p.His455Tyr), the latter of which was also present in an additional Dutch FEVR family that subsequently appeared to share a common ancestor with the original family.	Proline	55-62	norrin cystine knot growth factor NDP	Homo sapiens	252-256
23677916-6	2013	This mutation, Pro857Arg-CACNA1C, cosegregated with the disease within the pedigree, was ranked by 3 disease-network algorithms as the most probable LQTS-susceptibility gene and involves a conserved residue localizing to the proline, gltamic acid, serine, and threonine (PEST) domain in the II-III linker.	Proline	225-232	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	25-32
23586857-7	2013	SSO1273 protein is heavily glycosylated and all 20 theoretical N-X-S/T (where X is any amino acid except proline) consensus sequence sites were confirmed.	Proline	105-112	ABC transporter substrate-binding protein	Saccharolobus solfataricus P2	0-7
28324374-0	2013	Leucine to proline substitution by SNP at position 197 in Caspase-9 gene expression leads to neuroblastoma: a bioinformatics analysis.	Proline	11-18	caspase 9	Homo sapiens	58-67
23666597-4	2013	We further determined the interactional regions as the SH3 domain of CrkI and the proline-rich region between amino acids 462 and 468 of PTPN4.	Proline	82-89	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	137-142
23608644-10	2013	An additional PRR repeat into a proline-arginine-rich motif can dramatically changed the conformation of the intracellular domain of KISS1R and its probable interaction with partner proteins.	Proline	32-39	KISS1 receptor	Homo sapiens	133-139
23517290-3	2013	Previously, we showed that the Thr357Ala/Lys764Glu variant Rsp5 induces the constitutive inactivation of Gap1, which is mainly involved in uptake of the toxic proline analogue, l-azetidine-2-carboxylate (AZC).	Proline	159-166	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	59-63
23517290-3	2013	Previously, we showed that the Thr357Ala/Lys764Glu variant Rsp5 induces the constitutive inactivation of Gap1, which is mainly involved in uptake of the toxic proline analogue, l-azetidine-2-carboxylate (AZC).	Proline	159-166	amino acid permease GAP1	Saccharomyces cerevisiae S288C	105-109
23564202-3	2013	In animal and plant cells, impairment of P5C dehydrogenase activity results in P5C-proline cycling when exogenous proline is supplied via the actions of proline oxidase and P5C reductase (the enzyme that converts P5C to proline).	Proline	83-90	aldehyde dehydrogenase 4 family, member A1	Mus musculus	41-58
23564202-3	2013	In animal and plant cells, impairment of P5C dehydrogenase activity results in P5C-proline cycling when exogenous proline is supplied via the actions of proline oxidase and P5C reductase (the enzyme that converts P5C to proline).	Proline	114-121	aldehyde dehydrogenase 4 family, member A1	Mus musculus	41-58
23625637-0	2013	Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells.	Proline	23-30	transformation related protein 53	Mus musculus	47-51
23270686-6	2013	The PR-L contains a proline not existing in the epitope that is postulated to induce kinks in the backbones of all peptides and create a spatial element mimicking the N-terminal conformationally variable binding site.	Proline	20-27	prolactin	Homo sapiens	4-8
23625358-7	2013	Overexpression of AtERF53 in the rglg1rglg2 double mutant conferred better heat-stress tolerance and had resulted in higher endogenous ABA and proline levels compared to rglg1rglg2 double mutants.	Proline	143-150	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	18-25
23625358-7	2013	Overexpression of AtERF53 in the rglg1rglg2 double mutant conferred better heat-stress tolerance and had resulted in higher endogenous ABA and proline levels compared to rglg1rglg2 double mutants.	Proline	143-150	RING domain ligase1	Arabidopsis thaliana	33-43
23579020-3	2013	Dipeptidyl peptidases II and IV (DPPII and DPPIV) are serine proteases removing N-terminal dipeptides from polypeptides and proteins with proline or alanine on the penultimate position.	Proline	138-145	dipeptidyl peptidase 7	Homo sapiens	0-31
23579020-3	2013	Dipeptidyl peptidases II and IV (DPPII and DPPIV) are serine proteases removing N-terminal dipeptides from polypeptides and proteins with proline or alanine on the penultimate position.	Proline	138-145	dipeptidyl peptidase 7	Homo sapiens	33-38
23579020-3	2013	Dipeptidyl peptidases II and IV (DPPII and DPPIV) are serine proteases removing N-terminal dipeptides from polypeptides and proteins with proline or alanine on the penultimate position.	Proline	138-145	dipeptidyl peptidase 4	Homo sapiens	43-48
23618858-0	2013	Up-regulation of cyclin-E(1) via proline-mTOR pathway is responsible for HGF-mediated G(1)/S progression in the primary culture of rat hepatocytes.	Proline	33-40	cyclin E1	Rattus norvegicus	17-28
23603279-7	2013	Notably, the amp1-1 lines exhibited higher expression levels of ABA-responsive genes (RAB18, RD29A and RD29B), higher concentration of proline and lower reactive oxygen species (ROS) levels (H2O2 and O2(-)) after ABA and dehydration treatments than those of wild type.	Proline	135-142	Peptidase M28 family protein	Arabidopsis thaliana	13-17
23564481-0	2013	Association between the p53 codon 72 Arg/Pro polymorphism and hepatocellular carcinoma risk.	Proline	41-44	tumor protein p53	Homo sapiens	24-27
23564481-1	2013	Previous studies regarding the association of p53 codon 72 Arg/Pro polymorphism with hepatocellular carcinoma (HCC) risk have provided conflicting and inconclusive findings.	Proline	63-66	tumor protein p53	Homo sapiens	46-49
23564481-4	2013	The strength of the association of p53 codon 72 Arg/Pro polymorphism with HCC risk was estimated by the pooled odds ratio (OR) with its corresponding 95 % confidence interval (95 % CI).	Proline	52-55	tumor protein p53	Homo sapiens	35-38
23724134-3	2013	We identified a highly conserved proline-rich sequence within the C-terminus of the cotransporter which when mutated leads to loss of the KCC3-dependent regulatory volume decrease (RVD) response in Xenopus Laevis oocytes.	Proline	33-40	solute carrier family 12 member 6 L homeolog	Xenopus laevis	138-142
23618858-0	2013	Up-regulation of cyclin-E(1) via proline-mTOR pathway is responsible for HGF-mediated G(1)/S progression in the primary culture of rat hepatocytes.	Proline	33-40	mechanistic target of rapamycin kinase	Rattus norvegicus	41-45
23618858-0	2013	Up-regulation of cyclin-E(1) via proline-mTOR pathway is responsible for HGF-mediated G(1)/S progression in the primary culture of rat hepatocytes.	Proline	33-40	hepatocyte growth factor	Rattus norvegicus	73-76
23618858-5	2013	Using this in vitro model, we provide evidence that not only induction of cyclin-D1 by HGF but also up-regulation of cyclin-E1 by proline is required for hepatocytes to enter the S-phase.	Proline	130-137	cyclin E1	Rattus norvegicus	117-126
23618858-6	2013	Proline-enhanced cyclin-E1 induction, without changing its mRNA level, is associated with the activation of mammalian target of rapamycin (mTOR)-dependent pathways.	Proline	0-7	cyclin E1	Homo sapiens	17-26
23533246-5	2013	Three of the mutations involved proline 531, one of the two residues that controls HIF2alpha stability by hydroxylation.	Proline	32-39	endothelial PAS domain protein 1	Homo sapiens	83-92
23618858-6	2013	Proline-enhanced cyclin-E1 induction, without changing its mRNA level, is associated with the activation of mammalian target of rapamycin (mTOR)-dependent pathways.	Proline	0-7	mechanistic target of rapamycin kinase	Homo sapiens	108-137
23618858-6	2013	Proline-enhanced cyclin-E1 induction, without changing its mRNA level, is associated with the activation of mammalian target of rapamycin (mTOR)-dependent pathways.	Proline	0-7	mechanistic target of rapamycin kinase	Homo sapiens	139-143
23618858-7	2013	Indeed, proline enhanced the ribosomal protein S6 phosphorylations (i.e., mTOR target), concomitantly with an increase in cyclin-E1.	Proline	8-15	ribosomal protein S6	Rattus norvegicus	29-49
23618858-7	2013	Indeed, proline enhanced the ribosomal protein S6 phosphorylations (i.e., mTOR target), concomitantly with an increase in cyclin-E1.	Proline	8-15	mechanistic target of rapamycin kinase	Rattus norvegicus	74-78
23618858-7	2013	Indeed, proline enhanced the ribosomal protein S6 phosphorylations (i.e., mTOR target), concomitantly with an increase in cyclin-E1.	Proline	8-15	cyclin E1	Rattus norvegicus	122-131
23618858-8	2013	Inversely, mTOR-inhibitor, rapamycin suppressed the proline-mediated induction of cyclin-E1.	Proline	52-59	mechanistic target of rapamycin kinase	Rattus norvegicus	11-15
23618858-8	2013	Inversely, mTOR-inhibitor, rapamycin suppressed the proline-mediated induction of cyclin-E1.	Proline	52-59	cyclin E1	Rattus norvegicus	82-91
23618858-9	2013	As a result, DNA synthesis of hepatocytes, which was induced by HGF in the presence of proline, was largely abolished by mTOR-inhibitor treatment.	Proline	87-94	hepatocyte growth factor	Rattus norvegicus	64-67
23618858-9	2013	As a result, DNA synthesis of hepatocytes, which was induced by HGF in the presence of proline, was largely abolished by mTOR-inhibitor treatment.	Proline	87-94	mechanistic target of rapamycin kinase	Rattus norvegicus	121-125
23618858-10	2013	Such a co-mitogenic effect of proline was also dependent on collagen synthesis: collagen synthesis inhibitors, such as cis-OH-proline, diminished the proline-induced cyclin-E1, and then the G1/S progression of hepatocytes was also suppressed.	Proline	30-37	cyclin E1	Rattus norvegicus	166-175
23618858-10	2013	Such a co-mitogenic effect of proline was also dependent on collagen synthesis: collagen synthesis inhibitors, such as cis-OH-proline, diminished the proline-induced cyclin-E1, and then the G1/S progression of hepatocytes was also suppressed.	Proline	126-133	cyclin E1	Rattus norvegicus	166-175
23618858-11	2013	Overall, proline-mediated mTOR activation and collagen synthesis were found critical for HGF-induced DNA synthesis, partly via the sufficient accumulation of cyclin-E1.	Proline	9-16	mechanistic target of rapamycin kinase	Rattus norvegicus	26-30
23618858-11	2013	Overall, proline-mediated mTOR activation and collagen synthesis were found critical for HGF-induced DNA synthesis, partly via the sufficient accumulation of cyclin-E1.	Proline	9-16	hepatocyte growth factor	Rattus norvegicus	89-92
23618858-11	2013	Overall, proline-mediated mTOR activation and collagen synthesis were found critical for HGF-induced DNA synthesis, partly via the sufficient accumulation of cyclin-E1.	Proline	9-16	cyclin E1	Rattus norvegicus	158-167
23700433-3	2013	Here, we report that mutation of the central glycine in the pore-lining second transmembrane segment (TM2) to proline in Kir6.2 causes KATP channel inactivation.	Proline	110-117	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	121-127
23663243-1	2013	BACKGROUND: Codon 72 (Arg/Pro), the most frequently studied single nucleotide polymorphism (SNP) of p53 to date, is associated with the ability of the gene to induce cell apoptosis.	Proline	26-29	tumor protein p53	Homo sapiens	100-103
23519473-1	2013	Dipeptidyl peptidases (DP) 8 and 9 are homologous, cytoplasmic N-terminal post-proline-cleaving enzymes that are anti-targets for the development of DP4 (DPPIV/CD26) inhibitors for treating type II diabetes.	Proline	79-86	dipeptidyl peptidase 8	Homo sapiens	0-34
23519473-1	2013	Dipeptidyl peptidases (DP) 8 and 9 are homologous, cytoplasmic N-terminal post-proline-cleaving enzymes that are anti-targets for the development of DP4 (DPPIV/CD26) inhibitors for treating type II diabetes.	Proline	79-86	transcription factor Dp family member 3	Homo sapiens	149-152
23519473-1	2013	Dipeptidyl peptidases (DP) 8 and 9 are homologous, cytoplasmic N-terminal post-proline-cleaving enzymes that are anti-targets for the development of DP4 (DPPIV/CD26) inhibitors for treating type II diabetes.	Proline	79-86	dipeptidyl peptidase 4	Homo sapiens	154-159
23696840-1	2013	OBJECTIVE: Dipeptidyl peptidase (DPP)-4 is responsible for the degradation of several peptides that contain an alanine or proline at the penultimate position or position P1.	Proline	122-129	dipeptidylpeptidase 4	Mus musculus	11-39
23639512-3	2013	The wild-type p53 codon has two common polymorphic variants from a single-base-pair substitution at codon 72, where either C-C-C encodes proline (p53-p72) or C-G-C encodes arginine (p53-R72).	Proline	137-144	tumor protein p53	Homo sapiens	14-17
23602596-3	2013	A key pathway that is regulated by oxidative stress is the activation of proline-directed stress kinases (p38, JNK).	Proline	73-80	mitogen-activated protein kinase 14	Mus musculus	106-109
23602596-3	2013	A key pathway that is regulated by oxidative stress is the activation of proline-directed stress kinases (p38, JNK).	Proline	73-80	mitogen-activated protein kinase 8	Mus musculus	111-114
23532897-0	2013	Impact of the proline residue on ligand binding of neurotensin receptor 2 (NTS2)-selective peptide-peptoid hybrids.	Proline	14-21	neurotensin receptor 2	Homo sapiens	51-73
23532897-0	2013	Impact of the proline residue on ligand binding of neurotensin receptor 2 (NTS2)-selective peptide-peptoid hybrids.	Proline	14-21	neurotensin receptor 2	Homo sapiens	75-79
23637286-2	2013	These folding factors consist of classical chaperones and their cochaperones, the carbohydrate-binding chaperones, and the folding catalysts of the PDI and proline cis-trans isomerase families.	Proline	156-163	peptidyl arginine deiminase 1	Homo sapiens	148-151
23509317-10	2013	The HIF2A mutations in these patients were clustered adjacent to an oxygen-sensing proline residue, affecting HIF2alpha interaction with the prolyl hydroxylase domain 2-containing protein, decreasing the hydroxylation of HIF2alpha, and reducing HIF2alpha affinity for the von Hippel-Lindau protein and its degradation.	Proline	83-90	endothelial PAS domain protein 1	Homo sapiens	4-9
23509317-10	2013	The HIF2A mutations in these patients were clustered adjacent to an oxygen-sensing proline residue, affecting HIF2alpha interaction with the prolyl hydroxylase domain 2-containing protein, decreasing the hydroxylation of HIF2alpha, and reducing HIF2alpha affinity for the von Hippel-Lindau protein and its degradation.	Proline	83-90	endothelial PAS domain protein 1	Homo sapiens	110-119
23509317-10	2013	The HIF2A mutations in these patients were clustered adjacent to an oxygen-sensing proline residue, affecting HIF2alpha interaction with the prolyl hydroxylase domain 2-containing protein, decreasing the hydroxylation of HIF2alpha, and reducing HIF2alpha affinity for the von Hippel-Lindau protein and its degradation.	Proline	83-90	endothelial PAS domain protein 1	Homo sapiens	221-230
23509317-10	2013	The HIF2A mutations in these patients were clustered adjacent to an oxygen-sensing proline residue, affecting HIF2alpha interaction with the prolyl hydroxylase domain 2-containing protein, decreasing the hydroxylation of HIF2alpha, and reducing HIF2alpha affinity for the von Hippel-Lindau protein and its degradation.	Proline	83-90	endothelial PAS domain protein 1	Homo sapiens	221-230
23528987-0	2013	Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factor.	Proline	28-35	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	51-55
23528987-1	2013	Despite its key role in mediating a plethora of cellular signaling cascades pertinent to health and disease, little is known about the structural landscape of the proline-rich (PR) domain of Sos1 guanine nucleotide exchange factor.	Proline	163-170	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	191-195
23296366-5	2013	Other examples are the epimerase and the ATP-dependent dehydratase that repair hydrated forms of NADH and NADPH; ethylmalonyl-CoA decarboxylase, which eliminates an abnormal metabolite formed by acetyl-CoA carboxylase, an enzyme of fatty acid synthesis; L-pipecolate oxidase, which repairs a metabolite formed by a side activity of an enzyme of L-proline biosynthesis.	Proline	345-354	2,4-dienoyl-CoA reductase 1	Homo sapiens	106-111
23296366-5	2013	Other examples are the epimerase and the ATP-dependent dehydratase that repair hydrated forms of NADH and NADPH; ethylmalonyl-CoA decarboxylase, which eliminates an abnormal metabolite formed by acetyl-CoA carboxylase, an enzyme of fatty acid synthesis; L-pipecolate oxidase, which repairs a metabolite formed by a side activity of an enzyme of L-proline biosynthesis.	Proline	345-354	ethylmalonyl-CoA decarboxylase 1	Homo sapiens	113-143
23296366-5	2013	Other examples are the epimerase and the ATP-dependent dehydratase that repair hydrated forms of NADH and NADPH; ethylmalonyl-CoA decarboxylase, which eliminates an abnormal metabolite formed by acetyl-CoA carboxylase, an enzyme of fatty acid synthesis; L-pipecolate oxidase, which repairs a metabolite formed by a side activity of an enzyme of L-proline biosynthesis.	Proline	345-354	pipecolic acid and sarcosine oxidase	Homo sapiens	254-274
23330737-9	2013	Melatonin docked into the active site cleft of MMP-9 and interacted with key catalytic site residues including the three histidines that form the coordination complex with the catalytic zinc as well as proline 421 and alanine 191.	Proline	202-209	matrix metallopeptidase 9	Homo sapiens	47-52
23639512-3	2013	The wild-type p53 codon has two common polymorphic variants from a single-base-pair substitution at codon 72, where either C-C-C encodes proline (p53-p72) or C-G-C encodes arginine (p53-R72).	Proline	137-144	DEAD-box helicase 17	Homo sapiens	150-153
22665060-6	2013	Interaction occurs within the carboxyterminal proline-rich motif of ZO-2 and the SH3 domain in LASP-1.	Proline	46-53	tight junction protein 2	Homo sapiens	68-72
23475949-9	2013	The Pro(1228) residue is highly conserved from fungi to humans, and the P1228L mutation led to a partial loss in Cch1 function, but did not affect the localization and expression of Cch1.	Proline	4-7	Cch1p	Saccharomyces cerevisiae S288C	113-117
23888783-6	2013	The comparison of the occurrence of 20 amino acids for syndecan-1 from 32 animal organisms and 17 animal proteomes demonstrated that for the first such amino acids as glycine, treonine, glutamine, glutamic acid, and proline predominate on amount in the content of the former that results to the appearance of disordered regions in the proteins.	Proline	216-223	syndecan 1	Homo sapiens	55-65
23629966-6	2013	IFN-gamma-induced interaction of HDAC1 and p53 resulted in the deacetylation of p53 and suppression of Bmf expression independent of p53"s proline-rich domain.	Proline	139-146	interferon gamma	Homo sapiens	0-9
23629966-6	2013	IFN-gamma-induced interaction of HDAC1 and p53 resulted in the deacetylation of p53 and suppression of Bmf expression independent of p53"s proline-rich domain.	Proline	139-146	histone deacetylase 1	Homo sapiens	33-38
23629966-6	2013	IFN-gamma-induced interaction of HDAC1 and p53 resulted in the deacetylation of p53 and suppression of Bmf expression independent of p53"s proline-rich domain.	Proline	139-146	tumor protein p53	Homo sapiens	43-46
22665060-6	2013	Interaction occurs within the carboxyterminal proline-rich motif of ZO-2 and the SH3 domain in LASP-1.	Proline	46-53	LIM and SH3 protein 1	Homo sapiens	95-101
23637887-6	2013	Dcp1a interacted with Ddx6 and Edc3 through its proline-rich C-terminal extension, whereas the conserved EVH1 (enabled vasodilator-stimulated protein homology 1) domain in the N terminus of Dcp1a showed a stronger interaction with Dcp2.	Proline	48-55	decapping mRNA 1A	Mus musculus	0-5
23442005-4	2013	DFT calculations not only provide a good explanation for the formation of the sole cross-aldol product between two aliphatic aldehydes both bearing alpha-methylene protons but also well reproduce the opposite syn vs anti diastereoselectivities in the chiral amino sulfonamide and proline-catalyzed aldol reactions.	Proline	280-287	synemin	Homo sapiens	209-212
23610594-7	2013	We tested functionality of this site by inducing a glutamine-to-proline substitution expected to break the predicted alpha-helical structure; this significantly reduced FoxD4L1"s ability to repress zic3 and irx1.	Proline	64-71	forkhead box D4 like 1, gene 1 L homeolog	Xenopus laevis	169-176
23610594-7	2013	We tested functionality of this site by inducing a glutamine-to-proline substitution expected to break the predicted alpha-helical structure; this significantly reduced FoxD4L1"s ability to repress zic3 and irx1.	Proline	64-71	Zic family member 3 L homeolog	Xenopus laevis	198-202
23610594-7	2013	We tested functionality of this site by inducing a glutamine-to-proline substitution expected to break the predicted alpha-helical structure; this significantly reduced FoxD4L1"s ability to repress zic3 and irx1.	Proline	64-71	iroquois homeobox 1 L homeolog	Xenopus laevis	207-211
23378382-11	2013	Because GASA14 contains both GASA (GA-stimulated in Arabidopsis) and PRP (proline-rich protein) domains, the PRP domain coding sequence was overexpressed in Col plants and it was found that the growth of the transgenic plants and the responses to ABA and salt were not altered.	Proline	74-81	Gibberellin-regulated family protein	Arabidopsis thaliana	8-14
23480827-6	2013	FXa generation assays and Western blotting, used to monitor rates of FVIIIa inactivation and proteolysis at the primary cleavage site in the cofactor (Arg(336)), respectively, showed marked rate reductions relative to WT for the Lys39Ala, Lys37-Lys38-Lys39/Pro-Gln-Glu, Arg67Ala, and Arg74Ala variants.	Proline	257-260	coagulation factor X	Homo sapiens	0-3
23274895-8	2013	Furthermore, short hairpin RNA-mediated knockdown of hypothalamic LDH-A, an astrocytic component of the ANLS, also blunted the glucoregulatory action of proline.	Proline	153-160	lactate dehydrogenase A	Rattus norvegicus	66-71
23384938-1	2013	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase predominantly active in the nervous system where it regulates several processes such as neuronal migration, cytoskeletal dynamics, axonal guidance, and neurotransmission.	Proline	38-45	cyclin-dependent kinase 5	Mus musculus	0-25
23384938-1	2013	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase predominantly active in the nervous system where it regulates several processes such as neuronal migration, cytoskeletal dynamics, axonal guidance, and neurotransmission.	Proline	38-45	cyclin-dependent kinase 5	Mus musculus	27-31
23460737-3	2013	In this article, we show that THEMIS and the adapter molecule growth factor receptor-bound protein 2 (GRB2) associate constitutively through binding of a conserved PxRPxK motif within the proline-rich region 1 of THEMIS to the C-terminal SH3-domain of GRB2.	Proline	188-195	thymocyte selection associated	Homo sapiens	30-36
23460737-3	2013	In this article, we show that THEMIS and the adapter molecule growth factor receptor-bound protein 2 (GRB2) associate constitutively through binding of a conserved PxRPxK motif within the proline-rich region 1 of THEMIS to the C-terminal SH3-domain of GRB2.	Proline	188-195	growth factor receptor bound protein 2	Homo sapiens	62-100
23460737-3	2013	In this article, we show that THEMIS and the adapter molecule growth factor receptor-bound protein 2 (GRB2) associate constitutively through binding of a conserved PxRPxK motif within the proline-rich region 1 of THEMIS to the C-terminal SH3-domain of GRB2.	Proline	188-195	growth factor receptor bound protein 2	Homo sapiens	102-106
23460737-3	2013	In this article, we show that THEMIS and the adapter molecule growth factor receptor-bound protein 2 (GRB2) associate constitutively through binding of a conserved PxRPxK motif within the proline-rich region 1 of THEMIS to the C-terminal SH3-domain of GRB2.	Proline	188-195	thymocyte selection associated	Homo sapiens	213-219
23460737-3	2013	In this article, we show that THEMIS and the adapter molecule growth factor receptor-bound protein 2 (GRB2) associate constitutively through binding of a conserved PxRPxK motif within the proline-rich region 1 of THEMIS to the C-terminal SH3-domain of GRB2.	Proline	188-195	growth factor receptor bound protein 2	Homo sapiens	252-256
23461363-9	2013	The decrease in rac1 activity was evident in cells transfected with the p66shc mutant (proline motif mutant, at residues P47 to P50).	Proline	87-94	Rac family small GTPase 1	Homo sapiens	16-20
23348613-1	2013	Prolyl oligopeptidase is a serine protease that cleaves peptides shorter 30-mer at carboxyl side of an internal proline.	Proline	112-119	prolyl endopeptidase	Homo sapiens	0-21
23325923-7	2013	The C-terminal SH3-SH2-SH3 domain and proline-rich region of Vav1 are required for its interaction with c-Abl kinase, and c-Abl kinase probably regulates the activity of Vav1 by direct phosphorylation at Tyr-267 in the DH domain.	Proline	38-45	vav guanine nucleotide exchange factor 1	Homo sapiens	61-65
23325923-7	2013	The C-terminal SH3-SH2-SH3 domain and proline-rich region of Vav1 are required for its interaction with c-Abl kinase, and c-Abl kinase probably regulates the activity of Vav1 by direct phosphorylation at Tyr-267 in the DH domain.	Proline	38-45	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	104-109
23241025-0	2013	Loss of DJ-1 protein stability and cytoprotective function by Parkinson"s disease-associated proline-158 deletion.	Proline	93-100	Parkinsonism associated deglycase	Homo sapiens	8-12
23461363-9	2013	The decrease in rac1 activity was evident in cells transfected with the p66shc mutant (proline motif mutant, at residues P47 to P50).	Proline	87-94	pleckstrin	Homo sapiens	121-124
23461363-9	2013	The decrease in rac1 activity was evident in cells transfected with the p66shc mutant (proline motif mutant, at residues P47 to P50).	Proline	87-94	nuclear factor kappa B subunit 1	Homo sapiens	128-131
23418749-0	2013	Unique proline-rich domain regulates the chaperone function of AIPL1.	Proline	7-14	aryl hydrocarbon receptor interacting protein like 1	Homo sapiens	63-68
23325127-5	2013	The base substitutions change a glycine to arginine in the fibronectin type 3 domain of nephrin and a proline to arginine in a conserved proline-rich region in Neph3.	Proline	102-109	kirre like nephrin family adhesion molecule 2	Homo sapiens	160-165
23325127-5	2013	The base substitutions change a glycine to arginine in the fibronectin type 3 domain of nephrin and a proline to arginine in a conserved proline-rich region in Neph3.	Proline	137-144	kirre like nephrin family adhesion molecule 2	Homo sapiens	160-165
23415322-0	2013	The atrzf1 mutation of the novel RING-type E3 ubiquitin ligase increases proline contents and enhances drought tolerance in Arabidopsis.	Proline	73-80	RING/U-box superfamily protein	Arabidopsis thaliana	4-10
23415322-5	2013	Moreover, the ectopic expression of the AtRZF1 gene was very significantly influential in drought sensitive parameters including proline content, water loss, membrane ion leakage and the expression of dehydration stress-related genes.	Proline	129-136	RING/U-box superfamily protein	Arabidopsis thaliana	40-46
23535337-0	2013	Disruption of AtWNK8 enhances tolerance of Arabidopsis to salt and osmotic stresses via modulating proline content and activities of catalase and peroxidase.	Proline	99-106	with no lysine (K) kinase 8	Arabidopsis thaliana	14-20
23535337-5	2013	The wnk8 mutant also accumulated 1.43-fold more proline than the wild-type in the sorbitol treatment.	Proline	48-55	with no lysine (K) kinase 8	Arabidopsis thaliana	4-8
23535337-8	2013	Taken together, we revealed that maintaining higher CAT and POD activities might be one of the reasons that the disruption of AtWNK8 enhances the tolerance to salt stress, and accumulating more proline and higher activities of CAT and POD might result in the higher tolerance of WNK8 to osmotic stress.	Proline	194-201	peroxidase	Arabidopsis thaliana	60-63
23535337-8	2013	Taken together, we revealed that maintaining higher CAT and POD activities might be one of the reasons that the disruption of AtWNK8 enhances the tolerance to salt stress, and accumulating more proline and higher activities of CAT and POD might result in the higher tolerance of WNK8 to osmotic stress.	Proline	194-201	with no lysine (K) kinase 8	Arabidopsis thaliana	126-132
23535337-8	2013	Taken together, we revealed that maintaining higher CAT and POD activities might be one of the reasons that the disruption of AtWNK8 enhances the tolerance to salt stress, and accumulating more proline and higher activities of CAT and POD might result in the higher tolerance of WNK8 to osmotic stress.	Proline	194-201	with no lysine (K) kinase 8	Arabidopsis thaliana	128-132
23389435-3	2013	The following diastereoselective reductions afforded chiral 5-phenyl-2-alkylprolines which can be applied to asymmetric synthesis as organocatalysts or synthesis of biologically active proline based compounds, such as chiral alpha-alkylated analogues of (+)-RP66803, as potential CCK antagonists.	Proline	76-83	cholecystokinin	Homo sapiens	280-283
23418749-3	2013	In addition, AIPL1 harbors a unique C-terminal proline-rich domain (PRD).	Proline	47-54	aryl hydrocarbon receptor interacting protein like 1	Homo sapiens	13-18
23418749-8	2013	The unique proline-rich domain of AIPL1 is important for its chaperone function as its truncation severely affects the ability of AIPL1 to bind non-native proteins.	Proline	11-18	aryl hydrocarbon receptor interacting protein like 1	Homo sapiens	34-39
23418749-8	2013	The unique proline-rich domain of AIPL1 is important for its chaperone function as its truncation severely affects the ability of AIPL1 to bind non-native proteins.	Proline	11-18	aryl hydrocarbon receptor interacting protein like 1	Homo sapiens	130-135
23418749-9	2013	Furthermore, the proline-rich domain decreased the affinity of AIPL1 for Hsp90, implying that this domain acts as a negative regulator of the Hsp90 interaction besides being necessary for efficient binding of AIPL1 to non-native proteins.	Proline	17-24	aryl hydrocarbon receptor interacting protein like 1	Homo sapiens	63-68
23418749-9	2013	Furthermore, the proline-rich domain decreased the affinity of AIPL1 for Hsp90, implying that this domain acts as a negative regulator of the Hsp90 interaction besides being necessary for efficient binding of AIPL1 to non-native proteins.	Proline	17-24	heat shock protein 90 alpha family class A member 1	Homo sapiens	73-78
23418749-9	2013	Furthermore, the proline-rich domain decreased the affinity of AIPL1 for Hsp90, implying that this domain acts as a negative regulator of the Hsp90 interaction besides being necessary for efficient binding of AIPL1 to non-native proteins.	Proline	17-24	heat shock protein 90 alpha family class A member 1	Homo sapiens	142-147
23418749-9	2013	Furthermore, the proline-rich domain decreased the affinity of AIPL1 for Hsp90, implying that this domain acts as a negative regulator of the Hsp90 interaction besides being necessary for efficient binding of AIPL1 to non-native proteins.	Proline	17-24	aryl hydrocarbon receptor interacting protein like 1	Homo sapiens	209-214
22580604-6	2013	In addition, Pin1 recognizes four phosphorylated Ser/Thr-Pro motifs in RUNX3 via its WW domain.	Proline	57-60	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	13-17
23047022-3	2013	Since AChE does not possess a transmembrane domain, its anchorage in the membrane is established via the Proline Rich Membrane Anchor (PRiMA), a transmembrane protein.	Proline	105-112	acetylcholinesterase (Cartwright blood group)	Homo sapiens	6-10
23047022-3	2013	Since AChE does not possess a transmembrane domain, its anchorage in the membrane is established via the Proline Rich Membrane Anchor (PRiMA), a transmembrane protein.	Proline	105-112	proline rich membrane anchor 1	Homo sapiens	135-140
22580604-6	2013	In addition, Pin1 recognizes four phosphorylated Ser/Thr-Pro motifs in RUNX3 via its WW domain.	Proline	57-60	RUNX family transcription factor 3	Homo sapiens	71-76
23477725-7	2013	Second, a proline-rich peptide in HD-PTP binds the SH3 domain of STAM2.	Proline	10-17	protein tyrosine phosphatase non-receptor type 23	Homo sapiens	34-40
23416304-4	2013	A tiny covalent perturbation consisting in reversal of Pro(B28)-Lys(B29) residues in a human insulin analog is sufficient to prevent this process.	Proline	55-58	insulin	Homo sapiens	93-100
23477725-7	2013	Second, a proline-rich peptide in HD-PTP binds the SH3 domain of STAM2.	Proline	10-17	signal transducing adaptor molecule 2	Homo sapiens	65-70
23477725-8	2013	Similar proline-rich peptides on UBPY also bind STAM2 SH3 to facilitate EGFR deubiquitination.	Proline	8-15	ubiquitin specific peptidase 8	Homo sapiens	33-37
23487784-7	2013	Moreover, expression of HIF-1alpha in cells that express PHD2 does not induce dedifferentiation but expression of HIF-1alpha containing mutations in the proline residues that are hydroxylated by PHD2 induces dedifferentiation.	Proline	153-160	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-124
23487784-7	2013	Moreover, expression of HIF-1alpha in cells that express PHD2 does not induce dedifferentiation but expression of HIF-1alpha containing mutations in the proline residues that are hydroxylated by PHD2 induces dedifferentiation.	Proline	153-160	egl-9 family hypoxia inducible factor 1	Homo sapiens	195-199
23477725-8	2013	Similar proline-rich peptides on UBPY also bind STAM2 SH3 to facilitate EGFR deubiquitination.	Proline	8-15	signal transducing adaptor molecule 2	Homo sapiens	48-53
23477725-8	2013	Similar proline-rich peptides on UBPY also bind STAM2 SH3 to facilitate EGFR deubiquitination.	Proline	8-15	epidermal growth factor receptor	Homo sapiens	72-76
23421996-4	2013	Pin1 binds to PRDX1 through interacting with the phospho-Thr ( 90) -Pro ( 91) motif of PRDX1, and this interaction is abolished when the Thr ( 90) of PRDX1 is mutated.	Proline	68-71	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
23416007-2	2013	While HIF-1alpha in hypoxia translocates to the nucleus where it transcribes the target genes including vascular endothelial growth factor (VEGF) mRNA, HIF-1alpha is degraded under normoxia, which involves its proline hydroxylation and subsequent binding to the von Hippel-Lindau protein-Elongin B-Elogin C (VBC) complex.	Proline	210-217	hypoxia inducible factor 1 subunit alpha	Homo sapiens	6-16
23416007-2	2013	While HIF-1alpha in hypoxia translocates to the nucleus where it transcribes the target genes including vascular endothelial growth factor (VEGF) mRNA, HIF-1alpha is degraded under normoxia, which involves its proline hydroxylation and subsequent binding to the von Hippel-Lindau protein-Elongin B-Elogin C (VBC) complex.	Proline	210-217	vascular endothelial growth factor A	Homo sapiens	104-138
23416007-2	2013	While HIF-1alpha in hypoxia translocates to the nucleus where it transcribes the target genes including vascular endothelial growth factor (VEGF) mRNA, HIF-1alpha is degraded under normoxia, which involves its proline hydroxylation and subsequent binding to the von Hippel-Lindau protein-Elongin B-Elogin C (VBC) complex.	Proline	210-217	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-162
23362255-5	2013	Tau phosphorylation occurs mainly at proline-directed Ser/Thr sites, which are targeted by protein kinases such as GSK3beta and Cdk5.	Proline	37-44	microtubule associated protein tau	Homo sapiens	0-3
23362255-5	2013	Tau phosphorylation occurs mainly at proline-directed Ser/Thr sites, which are targeted by protein kinases such as GSK3beta and Cdk5.	Proline	37-44	glycogen synthase kinase 3 alpha	Homo sapiens	115-123
23362255-5	2013	Tau phosphorylation occurs mainly at proline-directed Ser/Thr sites, which are targeted by protein kinases such as GSK3beta and Cdk5.	Proline	37-44	cyclin dependent kinase 5	Homo sapiens	128-132
23362255-6	2013	We reported previously that dephosphorylation of Tau at Cdk5-mediated sites was enhanced by Pin1, a peptidyl-prolyl isomerase that stimulates dephosphorylation at proline-directed sites by protein phosphatase 2A.	Proline	163-170	microtubule associated protein tau	Homo sapiens	49-52
23362255-6	2013	We reported previously that dephosphorylation of Tau at Cdk5-mediated sites was enhanced by Pin1, a peptidyl-prolyl isomerase that stimulates dephosphorylation at proline-directed sites by protein phosphatase 2A.	Proline	163-170	cyclin dependent kinase 5	Homo sapiens	56-60
23362255-6	2013	We reported previously that dephosphorylation of Tau at Cdk5-mediated sites was enhanced by Pin1, a peptidyl-prolyl isomerase that stimulates dephosphorylation at proline-directed sites by protein phosphatase 2A.	Proline	163-170	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	92-96
23421996-4	2013	Pin1 binds to PRDX1 through interacting with the phospho-Thr ( 90) -Pro ( 91) motif of PRDX1, and this interaction is abolished when the Thr ( 90) of PRDX1 is mutated.	Proline	68-71	peroxiredoxin 1	Mus musculus	14-19
23374072-1	2013	The genetic missense A30P mutation of the wild-type alpha-synuclein protein results in the replacement of the 30th amino acid residue from alanine (Ala) to proline (Pro) and was initially found in the members of a German family who developed Parkinson"s disease.	Proline	156-163	synuclein alpha	Homo sapiens	52-67
23374072-1	2013	The genetic missense A30P mutation of the wild-type alpha-synuclein protein results in the replacement of the 30th amino acid residue from alanine (Ala) to proline (Pro) and was initially found in the members of a German family who developed Parkinson"s disease.	Proline	165-168	synuclein alpha	Homo sapiens	52-67
23421996-4	2013	Pin1 binds to PRDX1 through interacting with the phospho-Thr ( 90) -Pro ( 91) motif of PRDX1, and this interaction is abolished when the Thr ( 90) of PRDX1 is mutated.	Proline	68-71	peroxiredoxin 1	Mus musculus	87-92
23421996-4	2013	Pin1 binds to PRDX1 through interacting with the phospho-Thr ( 90) -Pro ( 91) motif of PRDX1, and this interaction is abolished when the Thr ( 90) of PRDX1 is mutated.	Proline	68-71	peroxiredoxin 1	Mus musculus	87-92
23546956-5	2013	G7453A changes amino acid 362 of PLTP from alanine to threonine, and C9888T changes amino acid 491 of PLTP from proline to serine.	Proline	112-119	phospholipid transfer protein	Bos taurus	102-106
23333752-1	2013	PIN1, a peptidyl-prolyl-isomerase, binds a specific motif comprising a phosphorylated serine or threonine preceding a proline (p-Ser/Thr-Pro) residue in proteins.	Proline	118-125	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
23473504-1	2013	A key step in the cyclooxygenase reaction cycle of cyclooxygenase 1 (COX-1) is abstraction of the pro-S hydrogen atom of the arachidonic acid by a radical that is formed at the protein residue Tyr-385.	Proline	98-103	prostaglandin-endoperoxide synthase 1	Homo sapiens	51-67
23473504-1	2013	A key step in the cyclooxygenase reaction cycle of cyclooxygenase 1 (COX-1) is abstraction of the pro-S hydrogen atom of the arachidonic acid by a radical that is formed at the protein residue Tyr-385.	Proline	98-103	prostaglandin-endoperoxide synthase 1	Homo sapiens	69-74
23205571-0	2013	Design, synthesis and structure-activity relationship of new arginine vasopressin analogues containing proline derivatives in position 2.	Proline	103-110	arginine vasopressin	Homo sapiens	70-81
23076992-3	2013	To accomplish these functions, zyxin recruits VASP to cellular sites via proline-rich binding sites near zyxin"s amino terminus.	Proline	73-80	zyxin	Homo sapiens	31-36
23076992-3	2013	To accomplish these functions, zyxin recruits VASP to cellular sites via proline-rich binding sites near zyxin"s amino terminus.	Proline	73-80	vasodilator stimulated phosphoprotein	Homo sapiens	46-50
23076992-3	2013	To accomplish these functions, zyxin recruits VASP to cellular sites via proline-rich binding sites near zyxin"s amino terminus.	Proline	73-80	zyxin	Homo sapiens	105-110
23076992-5	2013	Here we assess how zyxin-VASP binding through both the proline rich motifs and the LIM domains alters specific VASP functions.	Proline	55-62	zyxin	Homo sapiens	19-24
23076992-5	2013	Here we assess how zyxin-VASP binding through both the proline rich motifs and the LIM domains alters specific VASP functions.	Proline	55-62	vasodilator stimulated phosphoprotein	Homo sapiens	25-29
23076992-5	2013	Here we assess how zyxin-VASP binding through both the proline rich motifs and the LIM domains alters specific VASP functions.	Proline	55-62	vasodilator stimulated phosphoprotein	Homo sapiens	111-115
23658879-0	2013	Benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine, a prolyl endopeptidase inhibitor, modulates depression-like behavior of rats in forced swimming test and activities of proline-specific peptidases in the brain structures.	Proline	170-177	prolyl endopeptidase	Rattus norvegicus	53-73
23205571-1	2013	In this study, we present the synthesis and pharmacological properties of new analogues of arginine vasopressin modified in the N-terminal part of the molecule with proline derivatives: indoline-2-carboxylic acid (Ica) and (2S,4R)-4-(naphthalene-2-ylmethyl)pyrrolidine-2-carboxylic acid.	Proline	165-172	arginine vasopressin	Homo sapiens	100-111
23412361-1	2013	The C-Terminal Domain (CTD) of the large subunit (Rpb1) of RNA Polymerase II has a Tyrosine-Serine-Proline-Threonine-Serine-Proline-Serine repeat structure in many eukaryotes.	Proline	99-106	RNA polymerase II subunit A	Homo sapiens	50-54
23041351-7	2013	Moreover, transcriptional analysis of polyamine and proline metabolism genes (P5CS, P5CR, ADC, SPMS, SPDS, SAMDC, PAO, DAO) further supported the obtained data and revealed a complex SNP concentration-, time-, and developmental stage-dependent mechanism controlling endogenous proline and polyamine metabolite production.	Proline	52-59	aldehyde dehydrogenase 18 family member A1	Homo sapiens	78-82
23041351-7	2013	Moreover, transcriptional analysis of polyamine and proline metabolism genes (P5CS, P5CR, ADC, SPMS, SPDS, SAMDC, PAO, DAO) further supported the obtained data and revealed a complex SNP concentration-, time-, and developmental stage-dependent mechanism controlling endogenous proline and polyamine metabolite production.	Proline	52-59	pyrroline-5-carboxylate reductase 1	Homo sapiens	84-88
23041351-7	2013	Moreover, transcriptional analysis of polyamine and proline metabolism genes (P5CS, P5CR, ADC, SPMS, SPDS, SAMDC, PAO, DAO) further supported the obtained data and revealed a complex SNP concentration-, time-, and developmental stage-dependent mechanism controlling endogenous proline and polyamine metabolite production.	Proline	52-59	adenosylmethionine decarboxylase 1	Homo sapiens	107-112
23041351-7	2013	Moreover, transcriptional analysis of polyamine and proline metabolism genes (P5CS, P5CR, ADC, SPMS, SPDS, SAMDC, PAO, DAO) further supported the obtained data and revealed a complex SNP concentration-, time-, and developmental stage-dependent mechanism controlling endogenous proline and polyamine metabolite production.	Proline	52-59	polyamine oxidase	Homo sapiens	114-117
23041351-7	2013	Moreover, transcriptional analysis of polyamine and proline metabolism genes (P5CS, P5CR, ADC, SPMS, SPDS, SAMDC, PAO, DAO) further supported the obtained data and revealed a complex SNP concentration-, time-, and developmental stage-dependent mechanism controlling endogenous proline and polyamine metabolite production.	Proline	52-59	D-amino acid oxidase	Homo sapiens	119-122
23041351-7	2013	Moreover, transcriptional analysis of polyamine and proline metabolism genes (P5CS, P5CR, ADC, SPMS, SPDS, SAMDC, PAO, DAO) further supported the obtained data and revealed a complex SNP concentration-, time-, and developmental stage-dependent mechanism controlling endogenous proline and polyamine metabolite production.	Proline	277-284	aldehyde dehydrogenase 18 family member A1	Homo sapiens	78-82
23041351-7	2013	Moreover, transcriptional analysis of polyamine and proline metabolism genes (P5CS, P5CR, ADC, SPMS, SPDS, SAMDC, PAO, DAO) further supported the obtained data and revealed a complex SNP concentration-, time-, and developmental stage-dependent mechanism controlling endogenous proline and polyamine metabolite production.	Proline	277-284	D-amino acid oxidase	Homo sapiens	119-122
24707243-10	2013	In corresponding prodrugs, Pro inhibited constitutive Stat3 phosphorylation at 10 muM in MDA-MB-468 breast tumor cells.	Proline	27-30	signal transducer and activator of transcription 3	Homo sapiens	54-59
24707243-10	2013	In corresponding prodrugs, Pro inhibited constitutive Stat3 phosphorylation at 10 muM in MDA-MB-468 breast tumor cells.	Proline	27-30	latexin	Homo sapiens	82-85
23232983-9	2013	The metabolic production of glutamate from proline proceeds by proline             dehydrogenase (PRODH), producing superoxide.	Proline	43-50	proline dehydrogenase 1	Homo sapiens	98-103
23240817-3	2013	In this study we demonstrate that abi4 mutant plants accumulate lower levels of sodium ions and higher levels of proline than wild-type plants following salt stress.	Proline	113-120	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	34-38
23279110-0	2013	A proline-tyrosine nuclear localization signal (PY-NLS) is required for the nuclear import of fission yeast PAB2, but not of human PABPN1.	Proline	2-9	poly(A) binding protein nuclear 1	Homo sapiens	108-112
23279110-4	2013	Here, we show that Pab2 contains a proline-tyrosine nuclear localization signal (PY-NLS) that is necessary and sufficient for its nuclear localization and function.	Proline	35-42	poly(A) binding protein nuclear 1	Homo sapiens	19-23
23246644-6	2013	Specifically, MAVS residues 1-150, containing both the CARD domain and the N-terminal portion of the proline rich-region, and PB2 residues 1-37 are essential for PB2-MAVS virus-host protein-protein complex formation.	Proline	101-108	mitochondrial antiviral signaling protein	Homo sapiens	14-18
23412361-1	2013	The C-Terminal Domain (CTD) of the large subunit (Rpb1) of RNA Polymerase II has a Tyrosine-Serine-Proline-Threonine-Serine-Proline-Serine repeat structure in many eukaryotes.	Proline	124-131	RNA polymerase II subunit A	Homo sapiens	50-54
23445937-5	2013	However, a large body of literature shows that NEAA, particularly glutamine, glutamate, arginine and proline regulate physiological functions via cell signaling pathways, such as mammalian target of rapamycin, AMP-activated protein kinase, extracellular signal-related kinase, Jun kinase, mitogen-activated protein kinase, and NEAA-derived gaseous molecules (e.g., nitric oxide, carbon monoxide, and hydrogen sulfide).	Proline	101-108	mitogen-activated protein kinase 9	Homo sapiens	277-287
23373819-0	2013	Cis-trans isomerizations of proline residues are key to bradykinin conformations.	Proline	28-35	kininogen 1	Homo sapiens	56-66
23373819-1	2013	A recent ion mobility-mass spectrometry (IM-MS) study of the nonapeptide bradykinin (BK, amino acid sequence Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)) found evidence for 10 populations of conformations that depend upon the solution composition [J.	Proline	116-119	kininogen 1	Homo sapiens	73-83
23441967-7	2013	We determine here that the Ala/Pro rich region of GRASP directly interacts with the SH3 domain of Dock180.	Proline	31-34	trafficking regulator and scaffold protein tamalin	Homo sapiens	50-55
23441967-7	2013	We determine here that the Ala/Pro rich region of GRASP directly interacts with the SH3 domain of Dock180.	Proline	31-34	dedicator of cytokinesis 1	Homo sapiens	98-105
23305921-1	2013	We previously reported that caffeoyl-amino acidyl-hydroxamic acid (CA-Xaa-NHOH) acted as both a good antioxidant and tyrosinase inhibitor, in particular when caffeic acid was conjugated with proline or amino acids having aromatic ring like phenylalanine.	Proline	191-198	tyrosinase	Mus musculus	117-127
23429346-5	2013	This review will focus on the chemical syntheses of 3-substituted proline chimeras of potential use for peptide syntheses and as potential use as tools for SAR studies of biologically active peptides and the development of secondary structure mimetics.	Proline	66-73	sarcosine dehydrogenase	Homo sapiens	156-159
23373819-1	2013	A recent ion mobility-mass spectrometry (IM-MS) study of the nonapeptide bradykinin (BK, amino acid sequence Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)) found evidence for 10 populations of conformations that depend upon the solution composition [J.	Proline	116-119	pyrroline-5-carboxylate reductase 1	Homo sapiens	123-128
23373819-1	2013	A recent ion mobility-mass spectrometry (IM-MS) study of the nonapeptide bradykinin (BK, amino acid sequence Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)) found evidence for 10 populations of conformations that depend upon the solution composition [J.	Proline	123-126	kininogen 1	Homo sapiens	73-83
23373819-7	2013	IM-MS distributions of the analogue peptides, when compared to the distribution for BK, indicate the multiple structures are associated with different combinations of cis and trans forms of the three proline residues.	Proline	200-207	kininogen 1	Homo sapiens	84-86
23277198-0	2013	GSK3beta phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication.	Proline	53-60	glycogen synthase kinase 3 beta	Homo sapiens	0-8
23277198-12	2013	CONCLUSIONS: GSK3beta phosphorylates cMyBP-C on a novel site, which is positioned in the proline-alanine-rich region and increases kinetics of force development, suggesting a noncanonical role for GSK3beta at the sarcomere level.	Proline	89-96	glycogen synthase kinase 3 beta	Homo sapiens	13-21
23158502-0	2013	A novel Delta(1)-pyrroline-5-carboxylate synthetase gene of Medicago truncatula plays a predominant role in stress-induced proline accumulation during symbiotic nitrogen fixation.	Proline	123-130	delta-1-pyrroline-5-carboxylate synthase	Medicago truncatula	8-51
23158502-2	2013	Delta(1)-Pyrroline-5-carboxylate synthetase (P5CS), the committed-step enzyme of proline biosynthesis, is encoded by two duplicated genes in many plants.	Proline	81-88	delta-1-pyrroline-5-carboxylate synthase	Medicago truncatula	0-43
23296707-0	2013	Protein tyrosine phosphatase with proline-glutamine-serine-threonine-rich motifs negatively regulates TLR-triggered innate responses by selectively inhibiting IkappaB kinase beta/NF-kappaB activation.	Proline	34-41	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	159-178
23158502-2	2013	Delta(1)-Pyrroline-5-carboxylate synthetase (P5CS), the committed-step enzyme of proline biosynthesis, is encoded by two duplicated genes in many plants.	Proline	81-88	delta-1-pyrroline-5-carboxylate synthase	Medicago truncatula	45-49
23407864-2	2013	Furthermore, there is a mounting body of evidence implicating Pin1 in the emergence of pathological phenotypes in neurodegeneration and cancer through the isomerization of a wide variety of substrates at peptidyl-prolyl bonds where the residue preceding proline is a phosphorylated serine or threonine residue (i.e., pS/T-P motifs).	Proline	254-261	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	62-66
23228886-7	2013	When THP exposed NF-L was subjected to amino acid analysis, glutamate, proline and lysine residues were found to be particularly sensitive.	Proline	71-78	neurofilament light chain	Homo sapiens	17-21
22484427-0	2013	Activation of p53 following ionizing radiation, but not other stressors, is dependent on the proline-rich domain (PRD).	Proline	93-100	transformation related protein 53, pseudogene	Mus musculus	14-17
22484427-4	2013	The proline-rich domain (PRD) of p53 (residues 58-101) has been reported to be essential for the induction of apoptosis.	Proline	4-11	transformation related protein 53, pseudogene	Mus musculus	33-36
23290554-5	2013	The central region of both Las17 and WASP is rich in proline residues and is generally considered to bind to SH3-domain-containing proteins.	Proline	53-60	actin-binding protein LAS17	Saccharomyces cerevisiae S288C	27-32
23263184-6	2013	Here we report an unusual 2.0 A structure showing that ATP directly locks onto and orients two parts of HF onto human ProRS, so that one part of HF mimics bound proline and the other mimics the 3" end of bound tRNA.	Proline	161-168	prolyl-tRNA synthetase 2, mitochondrial	Homo sapiens	118-123
23374508-0	2013	Importance of uncharged polar residues and proline in the proximal two-thirds (Pro107-Ser128) of the highly conserved region of mouse ileal Na+-dependent bile acid transporter, Slc10a2, in transport activity and cellular expression.	Proline	43-50	solute carrier family 10, member 2	Mus musculus	177-184
23374508-6	2013	In this study, proline and uncharged polar residues in the remaining two-thirds of this region in mouse Slc10a2 were subjected to mutational analysis, and taurocholic acid uptake and cell surface localization were examined.	Proline	15-22	solute carrier family 10, member 2	Mus musculus	104-111
23374508-14	2013	CONCLUSIONS: The functional importance of proline and uncharged polar residues in the highly conserved region of mouse Slc10a2 was determined.	Proline	42-49	solute carrier family 10, member 2	Mus musculus	119-126
23290554-5	2013	The central region of both Las17 and WASP is rich in proline residues and is generally considered to bind to SH3-domain-containing proteins.	Proline	53-60	WASP actin nucleation promoting factor	Homo sapiens	37-41
23290554-9	2013	In vivo analysis of yeast strains expressing las17 mutated in the WH2 domain, one of its proline motifs, or both shows additive defects in actin organization and endocytosis, with the proline mutant conferring more severe phenotypes than the WH2 mutant.	Proline	89-96	actin-binding protein LAS17	Saccharomyces cerevisiae S288C	45-50
23290554-9	2013	In vivo analysis of yeast strains expressing las17 mutated in the WH2 domain, one of its proline motifs, or both shows additive defects in actin organization and endocytosis, with the proline mutant conferring more severe phenotypes than the WH2 mutant.	Proline	184-191	actin-binding protein LAS17	Saccharomyces cerevisiae S288C	45-50
22976002-0	2013	The impact of either 4-R-hydroxyproline or 4-R-fluoroproline on the conformation and SH3m-cort binding of HPK1 proline-rich peptide.	Proline	32-39	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	106-110
22711289-0	2013	Transport of L-proline by the proton-coupled amino acid transporter PAT2 in differentiated 3T3-L1 cells.	Proline	13-22	solute carrier family 36 (proton/amino acid symporter), member 2	Mus musculus	68-72
23104469-6	2013	The ORF3 protein interacts with the tumor susceptibility gene 101, a critical cellular protein required for the budding of enveloped viruses, through the Pro, Ser, Ala, and Pro (PSAP) motif in infected cells; ORF3 is co-localized with multivesicular bodies (MVBs) in the cytoplasm of infected cells, thus suggesting that HEV requires the MVB pathway for the egress of virus particles.	Proline	154-157	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	4-8
23237212-0	2013	Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST).	Proline	73-80	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	38-66
23237212-0	2013	Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST).	Proline	73-80	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	68-71
23237212-1	2013	Protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-, and threonine-rich sequence (PEST) is ubiquitously expressed and is a critical regulator of cell adhesion and migration.	Proline	35-42	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	0-28
23237212-1	2013	Protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-, and threonine-rich sequence (PEST) is ubiquitously expressed and is a critical regulator of cell adhesion and migration.	Proline	35-42	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	30-33
23284103-8	2013	Indeed, murine BMP15 activity was restored when specific residues through this region (Pro(329)/Tyr(330)) were replaced with the corresponding residues (Arg(329)/Asp(330)) from human BMP15.	Proline	87-90	bone morphogenetic protein 15	Mus musculus	15-20
23213190-4	2013	AA responses to the intrarenal conversion of the chymase-specific, ACE-resistant ANGI peptide ([Pro(11), D-Ala(12)]ANGI) to ANGII were significantly enhanced in kidneys of diabetic compared with control mice.	Proline	96-99	chymase 1, mast cell	Mus musculus	49-56
23213190-4	2013	AA responses to the intrarenal conversion of the chymase-specific, ACE-resistant ANGI peptide ([Pro(11), D-Ala(12)]ANGI) to ANGII were significantly enhanced in kidneys of diabetic compared with control mice.	Proline	96-99	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	67-70
23213190-4	2013	AA responses to the intrarenal conversion of the chymase-specific, ACE-resistant ANGI peptide ([Pro(11), D-Ala(12)]ANGI) to ANGII were significantly enhanced in kidneys of diabetic compared with control mice.	Proline	96-99	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	81-85
23213190-4	2013	AA responses to the intrarenal conversion of the chymase-specific, ACE-resistant ANGI peptide ([Pro(11), D-Ala(12)]ANGI) to ANGII were significantly enhanced in kidneys of diabetic compared with control mice.	Proline	96-99	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	115-119
23213190-6	2013	[Pro(11), D-Ala(12)]ANGI did not produce a significant AA vasoconstriction in control kidneys.	Proline	1-4	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	20-24
23445063-4	2013	Inbred mice were exposed to chronic hypoxia for 10 days with either no treatment (HPH) or with treatment with a proline analog that impairs collagen synthesis (CHOP-PEG; HPH + CP).	Proline	112-119	DNA-damage inducible transcript 3	Mus musculus	160-164
23445063-7	2013	Proline analog treatment limited increases in RV afterload (neither effective arterial elastance Ea nor total pulmonary vascular resistance significantly increased compared to CTL with CHOP-PEG), limited the development of pulmonary hypertension (CHOP-PEG reduced right ventricular systolic pressure by 10% compared to HPH, p &lt; 0.05), and limited RV hypertrophy (CHOP-PEG reduced RV mass by 18% compared to HPH, p &lt; 0.005).	Proline	0-7	DNA-damage inducible transcript 3	Mus musculus	247-251
23104469-6	2013	The ORF3 protein interacts with the tumor susceptibility gene 101, a critical cellular protein required for the budding of enveloped viruses, through the Pro, Ser, Ala, and Pro (PSAP) motif in infected cells; ORF3 is co-localized with multivesicular bodies (MVBs) in the cytoplasm of infected cells, thus suggesting that HEV requires the MVB pathway for the egress of virus particles.	Proline	154-157	tumor susceptibility 101	Homo sapiens	36-65
23104469-6	2013	The ORF3 protein interacts with the tumor susceptibility gene 101, a critical cellular protein required for the budding of enveloped viruses, through the Pro, Ser, Ala, and Pro (PSAP) motif in infected cells; ORF3 is co-localized with multivesicular bodies (MVBs) in the cytoplasm of infected cells, thus suggesting that HEV requires the MVB pathway for the egress of virus particles.	Proline	154-157	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	209-213
23221557-1	2013	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein is known as a regulator which recognizes phosphorylated Ser/Thr-Pro motifs and increases the rate of cis and trans amide isomer interconversion, thereby altering the conformation of its substrates.	Proline	134-137	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-54
22772900-0	2013	Effect of semax and its C-terminal fragment Pro-Gly-Pro on the expression of VEGF family genes and their receptors in experimental focal ischemia of the rat brain.	Proline	44-48	vascular endothelial growth factor A	Rattus norvegicus	77-81
23267019-1	2013	The adaptor protein Nck is inducibly recruited through its SH3.1 domain to a proline-rich sequence (PRS) in CD3epsilon after TCR engagement.	Proline	77-84	non-catalytic region of tyrosine kinase adaptor protein 1	Mus musculus	20-23
23267019-1	2013	The adaptor protein Nck is inducibly recruited through its SH3.1 domain to a proline-rich sequence (PRS) in CD3epsilon after TCR engagement.	Proline	77-84	CD3 antigen, epsilon polypeptide	Mus musculus	108-118
23267019-1	2013	The adaptor protein Nck is inducibly recruited through its SH3.1 domain to a proline-rich sequence (PRS) in CD3epsilon after TCR engagement.	Proline	77-84	T cell receptor alpha variable 6-3	Mus musculus	125-128
23221557-1	2013	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein is known as a regulator which recognizes phosphorylated Ser/Thr-Pro motifs and increases the rate of cis and trans amide isomer interconversion, thereby altering the conformation of its substrates.	Proline	134-137	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	56-60
23192640-1	2013	The genetic polymorphism of p53 codon 72 Arg/Pro has been implicated in oral cancer risk, but the results of previous studies remain controversial and ambiguous.	Proline	45-48	tumor protein p53	Homo sapiens	28-31
23166297-6	2013	Site-directed mutagenesis of the Env7 alanine-proline-glutamic acid (APE) motif Glu269 to alanine results in an unstable kinase-dead allele that is stabilized and redistributed to the detergent-resistant fraction by interruption of the proteasome system in vivo.	Proline	46-53	putative serine/threonine protein kinase ENV7	Saccharomyces cerevisiae S288C	33-37
23184230-6	2013	ahk1 mutants had reduced low psi(w) induction of Delta(1)-Pyrroline-5-Carboxylate Synthetase1 (P5CS1) and 9-cis-Epoxycarotenoid Dioxygenase3, which encode rate-limiting enzymes in proline and abscisic acid (ABA) synthesis, respectively.	Proline	180-187	histidine kinase 1	Arabidopsis thaliana	0-4
23184230-6	2013	ahk1 mutants had reduced low psi(w) induction of Delta(1)-Pyrroline-5-Carboxylate Synthetase1 (P5CS1) and 9-cis-Epoxycarotenoid Dioxygenase3, which encode rate-limiting enzymes in proline and abscisic acid (ABA) synthesis, respectively.	Proline	180-187	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	49-93
23184230-9	2013	This indicated that proline accumulation was regulated in part by posttranscriptional control of P5CS1 that was not affected by AHK1.	Proline	20-27	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	97-102
23260419-3	2013	In vitro binding studies revealed that RIP3 binds to the serine/proline/threonine-rich domain (amino acid 625-740) of Daxx.	Proline	64-71	receptor-interacting serine-threonine kinase 3	Rattus norvegicus	39-43
23260419-3	2013	In vitro binding studies revealed that RIP3 binds to the serine/proline/threonine-rich domain (amino acid 625-740) of Daxx.	Proline	64-71	death-domain associated protein	Rattus norvegicus	118-122
23169783-2	2013	Conventionally, activation of c-Src is often induced by the binding of proline-rich sequences to its SH3 domain.	Proline	71-78	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	30-35
23245753-5	2013	This may imply that an appropriate lipophilic group at the C-4 position of the proline moiety is beneficial for potent inhibition at GAT3.	Proline	79-86	solute carrier family 6 member 13	Homo sapiens	133-137
23351781-6	2013	RESULTS: Plasma glucose and insulin concentrations showed a greater increase in PRO-CHO compared with PRO (P&lt;0.001).	Proline	80-83	insulin	Homo sapiens	28-35
23212918-1	2013	Prolidase, also known as Xaa-Pro dipeptidase or peptidase D (PEPD), is a ubiquitously expressed cytosolic enzyme that hydrolyzes dipeptides with proline or hydroxyproline at the carboxyl terminus.	Proline	145-152	peptidase D	Homo sapiens	0-9
23212918-1	2013	Prolidase, also known as Xaa-Pro dipeptidase or peptidase D (PEPD), is a ubiquitously expressed cytosolic enzyme that hydrolyzes dipeptides with proline or hydroxyproline at the carboxyl terminus.	Proline	145-152	peptidase D	Homo sapiens	25-44
23212918-1	2013	Prolidase, also known as Xaa-Pro dipeptidase or peptidase D (PEPD), is a ubiquitously expressed cytosolic enzyme that hydrolyzes dipeptides with proline or hydroxyproline at the carboxyl terminus.	Proline	145-152	peptidase D	Homo sapiens	48-59
23212918-1	2013	Prolidase, also known as Xaa-Pro dipeptidase or peptidase D (PEPD), is a ubiquitously expressed cytosolic enzyme that hydrolyzes dipeptides with proline or hydroxyproline at the carboxyl terminus.	Proline	145-152	peptidase D	Homo sapiens	61-65
23184932-6	2013	Comparison between the wild-type (wt) EIAV-CA and a variant lacking the beta-hairpin structure demonstrated that folding of the beta-hairpin specifically extended the N terminus of helix alpha1 from Tyr(20) to Pro(17).	Proline	210-213	adrenoceptor alpha 1D	Homo sapiens	187-193
23239624-6	2013	We propose that EF-P and its eukaryotic homolog, eIF5A, are essential for the synthesis of a subset of proteins containing proline stretches in all cells.	Proline	123-130	eukaryotic translation initiation factor 5A	Homo sapiens	49-54
23026218-10	2013	This mutation causes leucine to be converted to proline at position 227 in helix 3 in the VDR ligand binding domain (LBD).	Proline	48-55	vitamin D receptor	Homo sapiens	90-93
23281774-1	2013	BACKGROUND: A proline-to-serine substitution at position-56 (P56S) of vesicle-associated membrane protein-associated protein B (VAPB) causes a form of dominantly inherited motor neuron disease (MND), including typical and atypical amyotrophic lateral sclerosis (ALS) and a mild late-onset spinal muscular atrophy (SMA).	Proline	14-21	vesicle-associated membrane protein, associated protein B and C	Mus musculus	128-132
23086915-8	2013	D-Pro(7)-Ang-(1-7), a novel Ang-(1-7) receptor antagonist, completely abolished the vasodilatory effects of Ang-(1-7), as did inhibition of endothelial nitric oxide synthase (eNOS) with N(G)-nitro-L-arginine methyl-ester, guanylate cyclase blockade with ODQ and endothelium denudation.	Proline	1-5	angiogenin	Rattus norvegicus	9-17
23086915-8	2013	D-Pro(7)-Ang-(1-7), a novel Ang-(1-7) receptor antagonist, completely abolished the vasodilatory effects of Ang-(1-7), as did inhibition of endothelial nitric oxide synthase (eNOS) with N(G)-nitro-L-arginine methyl-ester, guanylate cyclase blockade with ODQ and endothelium denudation.	Proline	1-5	angiogenin, ribonuclease A family, member 2	Rattus norvegicus	28-36
23086915-8	2013	D-Pro(7)-Ang-(1-7), a novel Ang-(1-7) receptor antagonist, completely abolished the vasodilatory effects of Ang-(1-7), as did inhibition of endothelial nitric oxide synthase (eNOS) with N(G)-nitro-L-arginine methyl-ester, guanylate cyclase blockade with ODQ and endothelium denudation.	Proline	1-5	angiogenin	Rattus norvegicus	28-36
23369061-6	2013	RESULTS: The workflow applied resulted in a set including 1,996 seed sequences that allowed the identification of 36 differentially expressed genes related to the biosynthesis of osmoprotectants [Proline (P5CS: 4, P5CR: 2), Trehalose (TPS1: 9, TPPB: 1), Glycine betaine (BADH: 4) and Myo-inositol (MIPS: 7, INPS1: 8)], also mapped in silico in the soybean genome (25 loci).	Proline	196-203	delta-pyrroline-5-carboxylate synthetase	Glycine max	205-209
24175818-1	2013	A functional polymorphism in the NQO1 gene, featuring a 609C&gt;T substitution,leading to proline to serine amino-acid and enzyme activity changes, has been implicated in cancer risk.	Proline	90-97	NAD(P)H quinone dehydrogenase 1	Homo sapiens	33-37
23462603-10	2013	CONCLUSION: We found that distinct molecular alterations of the PRODH gene result in abnormal proline levels.	Proline	94-101	proline dehydrogenase 1	Homo sapiens	64-69
23470771-5	2013	To identify the proteins that functionally interact with NatA, we designed mutants in which the second amino acid was substituted for proline in Ebp2 and functionally related proteins: Brx1, a partner of Ebp2 in ribosome biogenesis, and the ribosomal protein L36a/b, overexpression of which suppresses a growth defect in ebp2-14.	Proline	134-141	Ebp2p	Saccharomyces cerevisiae S288C	145-149
23210739-2	2013	The aim of the present study was to analyze the association of p53 codon72 (arginine/proline) polymorphism (rs1042522) and Murine Double Minute 2 (MDM2) SNP309 T/G (rs2279744) with the advancement of cervical cancer by using polymerase chain reaction-restriction fragment length polymorphism method followed by direct sequencing.	Proline	85-92	transformation related protein 53, pseudogene	Mus musculus	63-66
22975681-7	2013	Five Nadrin isoforms are known that share a unique GAP domain, a serine/threonine/proline-rich domain, a SH3-binding motif and an N-terminal BAR domain but differ in their C-terminus.	Proline	82-89	Rho GTPase activating protein 17	Homo sapiens	5-11
23772978-2	2013	Prolyl 3-hydroxylase-1 (P3H1), the enzyme responsible for converting proline to 3-hydroxyproline (3Hyp) in type I collagen, requires the coenzyme CRTAP for activity.	Proline	69-76	prolyl 3-hydroxylase 1	Homo sapiens	0-22
23772978-2	2013	Prolyl 3-hydroxylase-1 (P3H1), the enzyme responsible for converting proline to 3-hydroxyproline (3Hyp) in type I collagen, requires the coenzyme CRTAP for activity.	Proline	69-76	prolyl 3-hydroxylase 1	Homo sapiens	24-28
23772978-2	2013	Prolyl 3-hydroxylase-1 (P3H1), the enzyme responsible for converting proline to 3-hydroxyproline (3Hyp) in type I collagen, requires the coenzyme CRTAP for activity.	Proline	69-76	cartilage associated protein	Homo sapiens	146-151
23210739-2	2013	The aim of the present study was to analyze the association of p53 codon72 (arginine/proline) polymorphism (rs1042522) and Murine Double Minute 2 (MDM2) SNP309 T/G (rs2279744) with the advancement of cervical cancer by using polymerase chain reaction-restriction fragment length polymorphism method followed by direct sequencing.	Proline	85-92	transformed mouse 3T3 cell double minute 2	Mus musculus	147-151
23092908-7	2013	RESULTS: The distribution of Arg/Arg, Arg/Pro and Pro/Pro genotypes of codon 72 of the TP53 gene was: 46.8%, 46.8% and 6.4%, respectively in the ovarian carcinomas and 64.3%, 31.4% and 4.3%, respectively in the control group.	Proline	50-53	tumor protein p53	Homo sapiens	87-91
23092908-7	2013	RESULTS: The distribution of Arg/Arg, Arg/Pro and Pro/Pro genotypes of codon 72 of the TP53 gene was: 46.8%, 46.8% and 6.4%, respectively in the ovarian carcinomas and 64.3%, 31.4% and 4.3%, respectively in the control group.	Proline	42-45	tumor protein p53	Homo sapiens	87-91
23092908-7	2013	RESULTS: The distribution of Arg/Arg, Arg/Pro and Pro/Pro genotypes of codon 72 of the TP53 gene was: 46.8%, 46.8% and 6.4%, respectively in the ovarian carcinomas and 64.3%, 31.4% and 4.3%, respectively in the control group.	Proline	50-53	tumor protein p53	Homo sapiens	87-91
23979027-5	2013	Using a series of deletion mutants spanning the tau molecule, we further demonstrate that TOC1 has one continuous epitope located within amino acids 209-224, in the so-called proline rich region.	Proline	175-182	microtubule associated protein tau	Homo sapiens	48-51
23991369-2	2013	In human populations, the p53 gene contains a common single nucleotide polymorphism (SNP) affecting codon 72 that determines whether a proline (P72) or an arginine (R72) is present at this amino acid position of the polypeptide.	Proline	135-142	tumor protein p53	Homo sapiens	26-29
23231763-5	2013	Under drought conditions, mms21 mutants showed the highest survival rate and the slowest water loss, and accumulated a higher level of free proline compared to wild-type (WT) and MMS21 over-expression plants.	Proline	140-147	RING/U-box superfamily protein	Arabidopsis thaliana	26-31
23991369-2	2013	In human populations, the p53 gene contains a common single nucleotide polymorphism (SNP) affecting codon 72 that determines whether a proline (P72) or an arginine (R72) is present at this amino acid position of the polypeptide.	Proline	135-142	DEAD-box helicase 17	Homo sapiens	144-147
23155002-1	2013	BPGAP1 is a Rho GTPase-activating protein (RhoGAP) that regulates cell morphogenesis, cell migration, and ERK signaling by the concerted action of its proline-rich region (PRR), RhoGAP domain, and the BNIP-2 and Cdc42GAP homology (BCH) domain.	Proline	151-158	Rho GTPase activating protein 20	Rattus norvegicus	12-41
23179835-9	2013	M2 macrophages constitutively produce the enzyme arginase I (argI), which sequesters L-arginine from iNOS and results in the production of ornithine and downstream polyamines and L-proline.	Proline	179-188	arginase, liver	Mus musculus	49-59
23124863-1	2013	The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene in association with human papillomavirus (HPV) 16 E6 variants has been implicated as a risk marker in cervical neoplasia.	Proline	32-35	tumor protein p53	Homo sapiens	66-69
23124863-1	2013	The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene in association with human papillomavirus (HPV) 16 E6 variants has been implicated as a risk marker in cervical neoplasia.	Proline	39-42	tumor protein p53	Homo sapiens	66-69
23124863-1	2013	The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene in association with human papillomavirus (HPV) 16 E6 variants has been implicated as a risk marker in cervical neoplasia.	Proline	39-42	tumor protein p53	Homo sapiens	66-69
23186870-1	2013	Prolyl 3-hydroxylase1 (P3H1) is a collagen modifying enzyme which hydroxylates certain prolines in the Xaa position of conventional GlyXaaYaa triple helical sequence.	Proline	87-95	prolyl 3-hydroxylase 1	Mus musculus	0-21
23186870-1	2013	Prolyl 3-hydroxylase1 (P3H1) is a collagen modifying enzyme which hydroxylates certain prolines in the Xaa position of conventional GlyXaaYaa triple helical sequence.	Proline	87-95	prolyl 3-hydroxylase 1	Mus musculus	23-27
23332695-7	2013	The sequence space of class A GPCRs reveals the key role of mutations at the level of the TM2 and TM5 proline residues in the evolution of class A GPCRs.	Proline	102-109	tropomyosin 3	Homo sapiens	98-101
23155002-1	2013	BPGAP1 is a Rho GTPase-activating protein (RhoGAP) that regulates cell morphogenesis, cell migration, and ERK signaling by the concerted action of its proline-rich region (PRR), RhoGAP domain, and the BNIP-2 and Cdc42GAP homology (BCH) domain.	Proline	151-158	Rho GTPase activating protein 20	Rattus norvegicus	43-49
23155002-1	2013	BPGAP1 is a Rho GTPase-activating protein (RhoGAP) that regulates cell morphogenesis, cell migration, and ERK signaling by the concerted action of its proline-rich region (PRR), RhoGAP domain, and the BNIP-2 and Cdc42GAP homology (BCH) domain.	Proline	151-158	Eph receptor B1	Rattus norvegicus	106-109
23160480-1	2013	The first genetic defect in human signal transducer and activator of transcription (STAT)5b was identified in an individual with profound short stature and GH insensitivity, immune dysfunction, and severe pulmonary disease, and was caused by an alanine to proline substitution (A630P) within the Src homology-2 (SH2) domain.	Proline	256-263	signal transducer and activator of transcription 5B	Homo sapiens	34-91
24287595-4	2013	We previously reported that synaptopodin, a proline-rich actin-binding protein, induces stress fibres by blocking the Smurf1-mediated ubiquitination of RhoA.	Proline	44-51	synaptopodin	Homo sapiens	28-40
24287595-4	2013	We previously reported that synaptopodin, a proline-rich actin-binding protein, induces stress fibres by blocking the Smurf1-mediated ubiquitination of RhoA.	Proline	44-51	SMAD specific E3 ubiquitin protein ligase 1	Homo sapiens	118-124
24287595-4	2013	We previously reported that synaptopodin, a proline-rich actin-binding protein, induces stress fibres by blocking the Smurf1-mediated ubiquitination of RhoA.	Proline	44-51	ras homolog family member A	Homo sapiens	152-156
23555988-3	2013	The adaptor protein IRSp53 contains an I-BAR domain that deforms membranes into protrusions and binds to Rac, a CRIB motif that interacts with Cdc42, an SH3 domain that binds to many actin cytoskeletal regulators with proline-rich peptides including VASP, and the C-terminal variable region by splicing.	Proline	218-225	brain-specific angiogenesis inhibitor 1-associated protein 2	Mus musculus	20-26
23109421-6	2013	In vitro reconstitution showed that the role of SCF(Fbw7alpha) in cyclin E degradation, rather than ubiquitylation, is to serve as a cofactor of the prolyl cis-trans isomerase Pin1 in the isomerization of a noncanonical proline-proline bond in the cyclin E phosphodegron.	Proline	220-227	KIT ligand	Homo sapiens	48-51
23109421-6	2013	In vitro reconstitution showed that the role of SCF(Fbw7alpha) in cyclin E degradation, rather than ubiquitylation, is to serve as a cofactor of the prolyl cis-trans isomerase Pin1 in the isomerization of a noncanonical proline-proline bond in the cyclin E phosphodegron.	Proline	228-235	KIT ligand	Homo sapiens	48-51
23673634-0	2013	Coordinated activation of the Rac-GAP beta2-chimaerin by an atypical proline-rich domain and diacylglycerol.	Proline	69-76	Rac family small GTPase 1	Homo sapiens	30-33
23673634-0	2013	Coordinated activation of the Rac-GAP beta2-chimaerin by an atypical proline-rich domain and diacylglycerol.	Proline	69-76	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	38-43
23673634-3	2013	Here we identify an atypical proline-rich motif in chimaerins that binds to the adaptor protein Nck1.	Proline	29-36	NCK adaptor protein 1	Homo sapiens	96-100
23673634-8	2013	Our studies underscore a coordinated mechanism for beta2-chimaerin activation that involves lipid interactions via the C1 domain and protein-protein interactions via the N-terminal proline-rich region.	Proline	181-188	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	51-56
23555801-7	2013	Immunoprecipitation and mutational analysis demonstrated that the interaction between BANK1 and PLCg2 was dependent on specific tyrosine and proline residues on the adaptor protein.	Proline	141-148	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	86-91
23555801-7	2013	Immunoprecipitation and mutational analysis demonstrated that the interaction between BANK1 and PLCg2 was dependent on specific tyrosine and proline residues on the adaptor protein.	Proline	141-148	phospholipase C gamma 2	Homo sapiens	96-101
23555988-3	2013	The adaptor protein IRSp53 contains an I-BAR domain that deforms membranes into protrusions and binds to Rac, a CRIB motif that interacts with Cdc42, an SH3 domain that binds to many actin cytoskeletal regulators with proline-rich peptides including VASP, and the C-terminal variable region by splicing.	Proline	218-225	thymoma viral proto-oncogene 1	Mus musculus	105-108
23555988-3	2013	The adaptor protein IRSp53 contains an I-BAR domain that deforms membranes into protrusions and binds to Rac, a CRIB motif that interacts with Cdc42, an SH3 domain that binds to many actin cytoskeletal regulators with proline-rich peptides including VASP, and the C-terminal variable region by splicing.	Proline	218-225	cell division cycle 42	Mus musculus	143-148
23472201-4	2013	ASPP2 contains a disordered proline rich domain (ASPP2 Pro) that forms an intramolecular autoinhibitory interaction with the Ank-SH3 domains.	Proline	28-35	tumor protein p53 binding protein 2	Homo sapiens	0-5
23527010-4	2013	Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val(66)-Pro(85), which causes direct bacterial lysis.	Proline	158-161	retinoic acid receptor responder 2	Homo sapiens	116-124
23472201-4	2013	ASPP2 contains a disordered proline rich domain (ASPP2 Pro) that forms an intramolecular autoinhibitory interaction with the Ank-SH3 domains.	Proline	28-35	tumor protein p53 binding protein 2	Homo sapiens	49-54
23472201-4	2013	ASPP2 contains a disordered proline rich domain (ASPP2 Pro) that forms an intramolecular autoinhibitory interaction with the Ank-SH3 domains.	Proline	28-35	ankyrin 1	Homo sapiens	125-128
23760173-6	2013	LC-TOF-MS analyses showed that proline-betaxanthin (Pro-Bx) accumulated as the major betaxanthin in these transgenic BY2 cells.	Proline	31-38	F-box protein PP2-B11-like	Nicotiana tabacum	117-120
23516557-1	2013	Prolidase is the only human enzyme responsible for the digestion of iminodipeptides containing proline or hydroxyproline at their C-terminal end, being a key player in extracellular matrix remodeling.	Proline	95-102	peptidase D	Homo sapiens	0-9
23383183-5	2013	DNA sequence analysis of coding regions, intron-exon boundaries and promoters of Trpv5 and Trpv6 identified a novel T to C transition in codon 682 of TRPV5, mutating a conserved serine to a proline (S682P).	Proline	190-197	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	81-86
23383183-5	2013	DNA sequence analysis of coding regions, intron-exon boundaries and promoters of Trpv5 and Trpv6 identified a novel T to C transition in codon 682 of TRPV5, mutating a conserved serine to a proline (S682P).	Proline	190-197	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	91-96
23383183-5	2013	DNA sequence analysis of coding regions, intron-exon boundaries and promoters of Trpv5 and Trpv6 identified a novel T to C transition in codon 682 of TRPV5, mutating a conserved serine to a proline (S682P).	Proline	190-197	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	150-155
23372670-15	2013	We also suggest a role for proline in Kruppel-type zinc finger protein control of DNA expression, and in the nucleation and translocation of actin by the formin complex.	Proline	27-34	zinc finger protein 248	Homo sapiens	38-70
23469085-4	2013	Although Hof1 and Rvs167 are not orthologues, they both share an analogous structure, with an F-BAR or BAR domain at the amino terminus, capable of inducing membrane curvature, and SH3 domains at the carboxyl terminus that bind to specific proline-rich targets.	Proline	240-247	amphiphysin	Saccharomyces cerevisiae S288C	18-24
23308256-4	2013	IPS-1 is composed of N-terminal Caspase Activation and Recruitment Domain (CARD), proline-rich domain, intermediate domain, and C-terminal transmembrane (TM) domain.	Proline	82-89	mitochondrial antiviral signaling protein	Homo sapiens	0-5
23144454-5	2012	Binding of these two proteins occurs between the C terminus of K(V)10.1 and the proline-rich domain of cortactin, regions targeted by many post-translational modifications.	Proline	80-87	potassium voltage-gated channel modifier subfamily G member 3	Homo sapiens	63-71
23718000-3	2013	With the increasing concentration of sprayed proline, the root length, plant height and dry mass, and leaf chlorophyll a and b and carotenoid contents increased gradually to the levels of the control, the leaf proline and ascorbic acid contents and the leaf SOD activity increased, the leaf soluble protein content decreased after an initial increase, the leaf POD activity, MDA content and membrane permeability decreased, and the Zn accumulation increased while the Cd and Cu accumulation decreased.	Proline	45-52	peroxidase-like	Triticum aestivum	361-364
23144454-5	2012	Binding of these two proteins occurs between the C terminus of K(V)10.1 and the proline-rich domain of cortactin, regions targeted by many post-translational modifications.	Proline	80-87	cortactin	Homo sapiens	103-112
23144461-10	2012	The large number of proline residues in ADAMTS13 is consistent with the important role of cis-trans isomerization in the proper folding of this protein.	Proline	20-27	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	40-48
24163826-3	2012	A double mutation of two proline residues to alanine residues in the alphaIIb cytoplasmic domain, previously shown to disturb its conformation, inhibits chimeric alphaV/alphaIIbbeta3-CIB interaction.	Proline	25-32	calcium and integrin binding 1	Homo sapiens	183-186
23205738-3	2012	We used mass spectrometry to assign the two disulfide bonds in SR-BI that connect cysteines within the conserved Cys(321)-Pro(322)-Cys(323) (CPC) motif and connect Cys(280) to Cys(334).	Proline	122-125	scavenger receptor class B member 1	Homo sapiens	63-68
23131567-1	2012	Cytosolic aminopeptidase P1 (APP1) is one of the three known mammalian aminopeptidase Ps (APPs) that cleave the N-terminal amino acid residue of peptides in which the penultimate amino acid is proline.	Proline	193-200	X-prolyl aminopeptidase 1	Homo sapiens	29-33
22310290-7	2012	CBL directly binds to Smad3 through its proline-rich motif, thereby preventing Smad3 from interacting with Smad4 and blocking nuclear translocation of Smad3.	Proline	40-47	Cbl proto-oncogene	Homo sapiens	0-3
23109335-6	2012	Because osmolytes represent a class of compounds that stabilize protein folding and conformation, we sought to determine the extent to which the amino acid osmolyte l-proline might impact bivalent Fab complexation.	Proline	165-174	FA complementation group B	Homo sapiens	197-200
23109335-7	2012	We found that l-proline (i) inhibited the adoption of the conformation associated with bivalent complexation, (ii) preserved Fab monovalency, (iii) reversed the conformation of preformed bivalent Fabs to that of monovalent Fabs, and (iv) separated a significant percentage of preformed bivalent complexes into monovalent species.	Proline	14-23	FA complementation group B	Homo sapiens	125-128
23237413-5	2012	RESULTS: We show that Sbh1p when it is part of the Sec61 complex is phosphorylated on T5 which is flanked by proline residues.	Proline	109-116	Arf family guanine nucleotide exchange factor SBH1	Saccharomyces cerevisiae S288C	22-27
23237413-5	2012	RESULTS: We show that Sbh1p when it is part of the Sec61 complex is phosphorylated on T5 which is flanked by proline residues.	Proline	109-116	SEC61 translocon subunit alpha 1	Homo sapiens	51-56
22310290-7	2012	CBL directly binds to Smad3 through its proline-rich motif, thereby preventing Smad3 from interacting with Smad4 and blocking nuclear translocation of Smad3.	Proline	40-47	SMAD family member 3	Homo sapiens	22-27
22310290-7	2012	CBL directly binds to Smad3 through its proline-rich motif, thereby preventing Smad3 from interacting with Smad4 and blocking nuclear translocation of Smad3.	Proline	40-47	SMAD family member 3	Homo sapiens	79-84
22310290-7	2012	CBL directly binds to Smad3 through its proline-rich motif, thereby preventing Smad3 from interacting with Smad4 and blocking nuclear translocation of Smad3.	Proline	40-47	SMAD family member 4	Homo sapiens	107-112
22310290-7	2012	CBL directly binds to Smad3 through its proline-rich motif, thereby preventing Smad3 from interacting with Smad4 and blocking nuclear translocation of Smad3.	Proline	40-47	SMAD family member 3	Homo sapiens	79-84
23085078-4	2012	The proline-rich region of PNRC2 is bound to the EVH1 domain of Dcp1a, while its NR-box mediates the interaction with the hyperphosphorylated Upf1.	Proline	4-11	proline rich nuclear receptor coactivator 2	Homo sapiens	27-32
23110299-4	2012	A total of 3433 peptides, scores&gt;36 (p&lt;0.01), constituting 94% of the triple helix region of collagen alpha-1(I) provided a census of proline hydroxylation levels defined as the rate of site occupancy for each peptide isomer (r) and the total site occupancy for each proline residue (t).	Proline	140-147	adrenoceptor alpha 1D	Homo sapiens	108-115
23217259-5	2012	Mss51 contains two heme regulatory motifs or Cys-Pro-X domains located in its N terminus.	Proline	49-52	Mss51p	Saccharomyces cerevisiae S288C	0-5
23234543-9	2012	Finally, we show that pollen from p5cs1 p5cs2/P5CS2 plants contains less proline than wild type and that exogenous proline supplied from the beginning of another development can partially complement both morphological and functional pollen defects.	Proline	73-80	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	34-39
23234543-9	2012	Finally, we show that pollen from p5cs1 p5cs2/P5CS2 plants contains less proline than wild type and that exogenous proline supplied from the beginning of another development can partially complement both morphological and functional pollen defects.	Proline	73-80	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	40-45
23234543-9	2012	Finally, we show that pollen from p5cs1 p5cs2/P5CS2 plants contains less proline than wild type and that exogenous proline supplied from the beginning of another development can partially complement both morphological and functional pollen defects.	Proline	73-80	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	46-51
23234543-9	2012	Finally, we show that pollen from p5cs1 p5cs2/P5CS2 plants contains less proline than wild type and that exogenous proline supplied from the beginning of another development can partially complement both morphological and functional pollen defects.	Proline	115-122	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	34-39
23234543-9	2012	Finally, we show that pollen from p5cs1 p5cs2/P5CS2 plants contains less proline than wild type and that exogenous proline supplied from the beginning of another development can partially complement both morphological and functional pollen defects.	Proline	115-122	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	46-51
23234543-10	2012	CONCLUSIONS: Our data show that the development of the male gametophyte carrying mutations in both P5CS1 and P5CS2 is severely compromised, and indicate that proline is required for pollen development and transmission.	Proline	158-165	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	99-104
23234543-10	2012	CONCLUSIONS: Our data show that the development of the male gametophyte carrying mutations in both P5CS1 and P5CS2 is severely compromised, and indicate that proline is required for pollen development and transmission.	Proline	158-165	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	109-114
23085078-4	2012	The proline-rich region of PNRC2 is bound to the EVH1 domain of Dcp1a, while its NR-box mediates the interaction with the hyperphosphorylated Upf1.	Proline	4-11	decapping mRNA 1A	Homo sapiens	64-69
23085078-5	2012	The mode of PNRC2 interaction with Dcp1a is distinct from those observed in other EVH1/proline-rich ligands interactions.	Proline	87-94	proline rich nuclear receptor coactivator 2	Homo sapiens	12-17
23085078-5	2012	The mode of PNRC2 interaction with Dcp1a is distinct from those observed in other EVH1/proline-rich ligands interactions.	Proline	87-94	decapping mRNA 1A	Homo sapiens	35-40
23897115-10	2012	Increased A-II levels in the secretory phase may be responsible for endometrial growth by increasing polyamines and proline products.	Proline	116-123	NLR family pyrin domain containing 3	Homo sapiens	10-14
23147510-1	2012	The triplication of the DYRK1A gene encoding proline-directed serine/threonine kinase and located in the critical region of Down syndrome (DS) has been implicated in cognitive deficits and intellectual disability of individuals with DS.	Proline	45-52	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	24-30
22585093-0	2012	Proline protects liver from D-galactosamine hepatitis by activating the IL-6/STAT3 survival signaling pathway.	Proline	0-7	interleukin 6	Rattus norvegicus	72-76
22585093-0	2012	Proline protects liver from D-galactosamine hepatitis by activating the IL-6/STAT3 survival signaling pathway.	Proline	0-7	signal transducer and activator of transcription 3	Rattus norvegicus	77-82
22585093-8	2012	Proline administration significantly suppressed inflammatory infiltration in the live after 48 h, which was accompanied by depletion of plasma TNF-alpha, glutamic oxaloacetic transaminase, and glutamic pyruvic transaminase.	Proline	0-7	tumor necrosis factor	Rattus norvegicus	143-152
22585093-11	2012	These results suggest that the tissue-protective mechanism of proline involves the early activation of IL-6/STAT-3 pathway in the liver, with subsequent activation of the regenerative response and suppression of massive inflammatory activation.	Proline	62-69	interleukin 6	Rattus norvegicus	103-107
22585093-11	2012	These results suggest that the tissue-protective mechanism of proline involves the early activation of IL-6/STAT-3 pathway in the liver, with subsequent activation of the regenerative response and suppression of massive inflammatory activation.	Proline	62-69	signal transducer and activator of transcription 3	Rattus norvegicus	108-114
23041265-3	2012	FOXP3 is distinct from other subfamily members because of its unique proline rich amino (N)-terminal domain.	Proline	69-76	forkhead box P3	Homo sapiens	0-5
23065719-6	2012	The remaining variant, a missense change in HERC2 (c.1781C&gt;T, p.Pro594Leu), occurs in a highly conserved proline residue within an RCC1-like functional domain.	Proline	108-115	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Homo sapiens	44-49
23020770-7	2012	C31 binds directly to the PP2A catalytic subunit, through the asparagine, proline, threonine, tyrosine (NPTY) motif, which is essential for C31-induced tau hyperphosphorylation.	Proline	74-81	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	26-30
23032090-5	2012	Then we re-mapped this gene on porcine chromosome 2 and analysed its expression in several tissues including gastric oxyntic mucosa of weanling pigs in which PCSK1 processes the pre-pro-ghrelin into ghrelin, which in turn is involved in the control of feed intake and energy metabolism.	Proline	164-167	proprotein convertase subtilisin/kexin type 1	Sus scrofa	158-163
23032090-5	2012	Then we re-mapped this gene on porcine chromosome 2 and analysed its expression in several tissues including gastric oxyntic mucosa of weanling pigs in which PCSK1 processes the pre-pro-ghrelin into ghrelin, which in turn is involved in the control of feed intake and energy metabolism.	Proline	164-167	appetite-regulating hormone	Sus scrofa	186-193
23032090-5	2012	Then we re-mapped this gene on porcine chromosome 2 and analysed its expression in several tissues including gastric oxyntic mucosa of weanling pigs in which PCSK1 processes the pre-pro-ghrelin into ghrelin, which in turn is involved in the control of feed intake and energy metabolism.	Proline	164-167	appetite-regulating hormone	Sus scrofa	199-206
22726613-0	2012	Discovering novel alpha-aminoacyl-containing proline derivatives with potent and selective inhibitory activity against dipeptidyl peptidase IV: design, synthesis, biological evaluation, and molecular modeling.	Proline	45-52	dipeptidyl peptidase 4	Homo sapiens	119-142
22773041-3	2012	Herein, we describe a novel mutation in EGFR exon 20 in a female non-smoker bearing a lung adenocarcinoma, characterized by the insertion of a nucleotide triplet GTT, which translates into a protein with an additional Valine between Proline 772 and Histidine 773 (p.P772_H773insV-c.2316_2317insGTT).	Proline	233-240	epidermal growth factor receptor	Homo sapiens	40-44
22973029-3	2012	CyPA binds to proline residues in the C-terminal half of NS5A, in a distributed fashion, and modulates the structure of the disordered domains II and III.	Proline	14-21	peptidylprolyl isomerase A	Homo sapiens	0-4
22992812-1	2012	Proline-, glutamic acid- and leucine-rich protein-1/modulator of non-genomic             activity of estrogen receptor (ER) (PELP1/MNAR) is a novel nuclear receptor (NR)             co-activator that plays an essential role in the actions of ER.	Proline	0-7	proline, glutamate and leucine rich protein 1	Homo sapiens	125-130
23053979-0	2012	p53 Codon 72 arginine/proline polymorphism and cancer in Sudan.	Proline	22-29	tumor protein p53	Homo sapiens	0-3
23053979-1	2012	The aim of this report is to determine frequencies and associations of p53 codon 72 arg/pro polymorphism with different types of cancer in Sudan.	Proline	88-91	tumor protein p53	Homo sapiens	71-74
23053979-8	2012	We concluded that p53 arg/pro polymorphism has different pattern of frequency in different types of cancer among Sudanese patients, indicating perhaps different etiology and biology of these tumours.	Proline	26-29	tumor protein p53	Homo sapiens	18-21
23142987-5	2012	The NMR structure of the DCP1 EVH1 domain bound to the DBM reveals that the peptide docks at a conserved aromatic cleft, which is used by EVH1 domains to recognize proline-rich ligands.	Proline	164-171	Death caspase-1	Drosophila melanogaster	25-29
22992812-1	2012	Proline-, glutamic acid- and leucine-rich protein-1/modulator of non-genomic             activity of estrogen receptor (ER) (PELP1/MNAR) is a novel nuclear receptor (NR)             co-activator that plays an essential role in the actions of ER.	Proline	0-7	proline, glutamate and leucine rich protein 1	Homo sapiens	131-135
23171218-4	2012	RESULTS: Gene expression studies revealed that the accumulation of proline was mediated by an increase in the expression of the proline synthesis genes P5CS1 and P5CS2 and a marginal reduction in the expression of the proline dehydrogenase (ProDH) gene.	Proline	67-74	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	152-157
23060441-6	2012	The alpha1(V) collagenous COL1 domain is thought to contain greater numbers of post-translational modifications (PTMs) than do similar domains of other fibrillar collagen chains, PTMs consisting of hydroxylated prolines and lysines, the latter of which can be glycosylated.	Proline	211-219	collagen type V alpha 1 chain	Homo sapiens	4-13
22922879-3	2012	StCDPK3 encodes a 63 kDa protein with an N-terminal variable domain (NTV), rich in prolines and glutamines, which presents myristoylation and palmitoylation consensus sites and a PEST sequence indicative of rapid protein degradation.	Proline	83-91	calcium-dependent protein kinase 3	Solanum tuberosum	0-7
23342381-7	2012	Furthermore, a 15 amino acid long peptide fused N terminally to GFP coding sequences confirmed involvement of proline at 310 in CypA binding.	Proline	110-117	peptidylprolyl isomerase A	Homo sapiens	128-132
23342381-8	2012	Our findings are consistent with CypA acting on multiple prolines outside of the previously identified CypA binding sites.	Proline	57-65	peptidylprolyl isomerase A	Homo sapiens	33-37
23181695-7	2012	Upon activation of the receptor kinase, the SH2 domain of Nck binds to one of its tyrosine residues, while Nck SH3 domains interact with the proline-rich domain of Caskin1.	Proline	141-148	NCK adaptor protein 1	Homo sapiens	107-110
23181695-7	2012	Upon activation of the receptor kinase, the SH2 domain of Nck binds to one of its tyrosine residues, while Nck SH3 domains interact with the proline-rich domain of Caskin1.	Proline	141-148	CASK interacting protein 1	Homo sapiens	164-171
23072893-5	2012	In this study, sera of children with history of pneumococcal colonization were analyzed for presence of IgG antibodies to the conserved proline-rich region (PRR) of PspA.	Proline	136-143	nuclear receptor subfamily 1 group I member 2	Homo sapiens	157-160
23072893-5	2012	In this study, sera of children with history of pneumococcal colonization were analyzed for presence of IgG antibodies to the conserved proline-rich region (PRR) of PspA.	Proline	136-143	surfactant protein A1	Homo sapiens	165-169
23171218-4	2012	RESULTS: Gene expression studies revealed that the accumulation of proline was mediated by an increase in the expression of the proline synthesis genes P5CS1 and P5CS2 and a marginal reduction in the expression of the proline dehydrogenase (ProDH) gene.	Proline	67-74	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	162-167
23046926-4	2012	A novel mutation at codon 163 was found in PSEN1, which was changed from histidine to proline.	Proline	86-93	presenilin 1	Homo sapiens	43-48
23171218-4	2012	RESULTS: Gene expression studies revealed that the accumulation of proline was mediated by an increase in the expression of the proline synthesis genes P5CS1 and P5CS2 and a marginal reduction in the expression of the proline dehydrogenase (ProDH) gene.	Proline	67-74	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	218-239
23171218-4	2012	RESULTS: Gene expression studies revealed that the accumulation of proline was mediated by an increase in the expression of the proline synthesis genes P5CS1 and P5CS2 and a marginal reduction in the expression of the proline dehydrogenase (ProDH) gene.	Proline	67-74	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	241-246
23012356-0	2012	Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin protein.	Proline	44-51	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	38-43
23077017-1	2012	OBJECTIVE: Whole genome sequencing and the screening of 103 families recently led us to identify PRRT2 (proline-rich-transmembrane protein) as the gene causing infantile convulsions (IC) with paroxysmal kinesigenic dyskinesia (PKD) (PKD/IC syndrome, formerly ICCA).	Proline	104-111	proline rich transmembrane protein 2	Homo sapiens	97-102
23012356-0	2012	Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin protein.	Proline	44-51	huntingtin	Homo sapiens	92-102
23077024-1	2012	OBJECTIVE: The proline-rich transmembrane protein (PRRT2) gene was recently identified using exome sequencing as the cause of autosomal dominant paroxysmal kinesigenic dyskinesia (PKD) with or without infantile convulsions (IC) (PKD/IC syndrome).	Proline	15-22	proline rich transmembrane protein 2	Homo sapiens	51-56
23012356-3	2012	Here, using a live cell assay and affinity chromatography, we show that huntingtin has a karyopherin beta2-dependent proline-tyrosine (PY)-NLS in the amino terminus of the protein.	Proline	117-124	huntingtin	Homo sapiens	72-82
23012356-3	2012	Here, using a live cell assay and affinity chromatography, we show that huntingtin has a karyopherin beta2-dependent proline-tyrosine (PY)-NLS in the amino terminus of the protein.	Proline	117-124	transportin 1	Homo sapiens	89-106
23001178-0	2012	Conformational modulation of Ant-Pro oligomers using chirality alteration of proline residues.	Proline	77-84	solute carrier family 25 member 6	Homo sapiens	29-32
23101761-1	2012	The choice of the anion of an achiral TBD-derived guanidinium salt, used as cocatalyst for proline, allows reacting cycloketones with aromatic aldehydes and preparing either anti- or syn-aldol adducts with very high enantioselectivity.	Proline	91-98	synemin	Homo sapiens	183-186
23101761-3	2012	The origin of the syn diastereoselectivity unfolds from an unusual equilibrium process coupled to the enamine-based catalytic cycle standard for proline.	Proline	145-152	synemin	Homo sapiens	18-21
22968170-1	2012	Fused in sarcoma (FUS) is a nuclear protein that carries a proline-tyrosine nuclear localization signal (PY-NLS) and is imported into the nucleus via Transportin (TRN).	Proline	59-66	FUS RNA binding protein	Homo sapiens	0-16
22968170-1	2012	Fused in sarcoma (FUS) is a nuclear protein that carries a proline-tyrosine nuclear localization signal (PY-NLS) and is imported into the nucleus via Transportin (TRN).	Proline	59-66	FUS RNA binding protein	Homo sapiens	18-21
22968170-1	2012	Fused in sarcoma (FUS) is a nuclear protein that carries a proline-tyrosine nuclear localization signal (PY-NLS) and is imported into the nucleus via Transportin (TRN).	Proline	59-66	transportin 1	Homo sapiens	150-161
22968170-1	2012	Fused in sarcoma (FUS) is a nuclear protein that carries a proline-tyrosine nuclear localization signal (PY-NLS) and is imported into the nucleus via Transportin (TRN).	Proline	59-66	transportin 1	Homo sapiens	163-166
23001178-1	2012	Structural modulation of Ant-Pro (anthranilic acid-proline) oligomers has been carried out by chirality alteration of the proline residues.	Proline	51-58	solute carrier family 25 member 6	Homo sapiens	25-28
23131831-9	2012	Our study thus demonstrates that the Y374 or S377 residue located at the C-terminal proline-rich domain of human IKKgamma/NEMO undergoes phosphorylation upon TNF-alpha treatment or KvFLIP expression, respectively, resulting in the suppression of IKKgamma/NEMO activity to induce NF-kappaB activation.	Proline	84-91	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	113-121
22489897-1	2012	Glycogen synthase kinase-3beta, also called tau phosphorylating kinase, is a proline-directed serine/threonine kinase which was originally identified due to its role in glycogen metabolism.	Proline	77-84	glycogen synthase kinase 3 beta	Homo sapiens	0-30
23131831-9	2012	Our study thus demonstrates that the Y374 or S377 residue located at the C-terminal proline-rich domain of human IKKgamma/NEMO undergoes phosphorylation upon TNF-alpha treatment or KvFLIP expression, respectively, resulting in the suppression of IKKgamma/NEMO activity to induce NF-kappaB activation.	Proline	84-91	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	122-126
23131831-9	2012	Our study thus demonstrates that the Y374 or S377 residue located at the C-terminal proline-rich domain of human IKKgamma/NEMO undergoes phosphorylation upon TNF-alpha treatment or KvFLIP expression, respectively, resulting in the suppression of IKKgamma/NEMO activity to induce NF-kappaB activation.	Proline	84-91	tumor necrosis factor	Homo sapiens	158-167
23131831-9	2012	Our study thus demonstrates that the Y374 or S377 residue located at the C-terminal proline-rich domain of human IKKgamma/NEMO undergoes phosphorylation upon TNF-alpha treatment or KvFLIP expression, respectively, resulting in the suppression of IKKgamma/NEMO activity to induce NF-kappaB activation.	Proline	84-91	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	246-254
23131831-9	2012	Our study thus demonstrates that the Y374 or S377 residue located at the C-terminal proline-rich domain of human IKKgamma/NEMO undergoes phosphorylation upon TNF-alpha treatment or KvFLIP expression, respectively, resulting in the suppression of IKKgamma/NEMO activity to induce NF-kappaB activation.	Proline	84-91	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	255-259
23131831-9	2012	Our study thus demonstrates that the Y374 or S377 residue located at the C-terminal proline-rich domain of human IKKgamma/NEMO undergoes phosphorylation upon TNF-alpha treatment or KvFLIP expression, respectively, resulting in the suppression of IKKgamma/NEMO activity to induce NF-kappaB activation.	Proline	84-91	nuclear factor kappa B subunit 1	Homo sapiens	279-288
22922962-0	2012	Novel role of proline-rich nonreceptor tyrosine kinase 2 in vascular wall remodeling after balloon injury.	Proline	14-21	tyrosine kinase 2	Homo sapiens	39-56
22989884-2	2012	WNK1 affects ion transport in part through activation of the closely related Ste20 family protein kinases oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-, alanine-rich kinase (SPAK).	Proline	166-173	WNK lysine deficient protein kinase 1	Homo sapiens	0-4
22989884-2	2012	WNK1 affects ion transport in part through activation of the closely related Ste20 family protein kinases oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-, alanine-rich kinase (SPAK).	Proline	166-173	serine/threonine kinase 24	Homo sapiens	77-82
22989884-2	2012	WNK1 affects ion transport in part through activation of the closely related Ste20 family protein kinases oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-, alanine-rich kinase (SPAK).	Proline	166-173	serine/threonine kinase 24	Homo sapiens	147-152
22989884-2	2012	WNK1 affects ion transport in part through activation of the closely related Ste20 family protein kinases oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-, alanine-rich kinase (SPAK).	Proline	166-173	serine/threonine kinase 39	Homo sapiens	197-201
22922962-1	2012	OBJECTIVE: To investigate the role of Pyk2, a proline-rich nonreceptor tyrosine kinase, in G protein-coupled receptor agonist, thrombin-induced human aortic smooth muscle cell growth and migration, and injury-induced vascular wall remodeling.	Proline	46-53	protein tyrosine kinase 2 beta	Homo sapiens	38-42
22892830-8	2012	In addition, a higher frequency of cytogenetic aberrations was observed in p53 variants having the homozygous proline genotype compared to variants having other genotypes both in patients and healthy individuals.	Proline	110-117	tumor protein p53	Homo sapiens	75-78
22886911-1	2012	Proline dehydrogenase (oxidase, PRODH/POX), the first enzyme in the proline degradative pathway, plays a special role in tumorigenesis and tumor development.	Proline	68-75	proline dehydrogenase 1	Homo sapiens	32-37
22886911-1	2012	Proline dehydrogenase (oxidase, PRODH/POX), the first enzyme in the proline degradative pathway, plays a special role in tumorigenesis and tumor development.	Proline	68-75	proline dehydrogenase 1	Homo sapiens	38-41
22886911-2	2012	Proline metabolism catalyzed by PRODH/POX is closely linked with the tricarboxylic acid (TCA) cycle and urea cycle.	Proline	0-7	proline dehydrogenase 1	Homo sapiens	32-37
22886911-2	2012	Proline metabolism catalyzed by PRODH/POX is closely linked with the tricarboxylic acid (TCA) cycle and urea cycle.	Proline	0-7	proline dehydrogenase 1	Homo sapiens	38-41
22886911-4	2012	Importantly, by catalyzing proline to P5C, PRODH/POX donates electrons into the electron transport chain to generate ROS or ATP.	Proline	27-34	proline dehydrogenase 1	Homo sapiens	43-48
22886911-4	2012	Importantly, by catalyzing proline to P5C, PRODH/POX donates electrons into the electron transport chain to generate ROS or ATP.	Proline	27-34	proline dehydrogenase 1	Homo sapiens	49-52
22820502-8	2012	In addition, SHIP1 mutant P1039S which does not reduce PI3K/AKT signaling anymore is located in a PXXP SH3 domain consensus binding motif suggesting that mutation of the conserved proline residue interferes with binding of SHIP1 to a so far unidentified SH3 domain containing protein.	Proline	180-187	inositol polyphosphate-5-phosphatase D	Homo sapiens	13-18
22796189-6	2012	Similar to other CDKs, PCTAIRE-1 requires a proline residue immediately C-terminal to the phosphoacceptor site (+1) for optimal activity.	Proline	44-51	cyclin dependent kinase 2	Homo sapiens	17-21
22820502-8	2012	In addition, SHIP1 mutant P1039S which does not reduce PI3K/AKT signaling anymore is located in a PXXP SH3 domain consensus binding motif suggesting that mutation of the conserved proline residue interferes with binding of SHIP1 to a so far unidentified SH3 domain containing protein.	Proline	180-187	inositol polyphosphate-5-phosphatase D	Homo sapiens	223-228
22796189-6	2012	Similar to other CDKs, PCTAIRE-1 requires a proline residue immediately C-terminal to the phosphoacceptor site (+1) for optimal activity.	Proline	44-51	cyclin dependent kinase 16	Homo sapiens	23-32
22865229-2	2012	IL-4-induced activation of macrophages produced arginase-1, which converts arginine into ornithine, a precursor of polyamines and proline.	Proline	130-137	interleukin 4	Mus musculus	0-4
22865229-2	2012	IL-4-induced activation of macrophages produced arginase-1, which converts arginine into ornithine, a precursor of polyamines and proline.	Proline	130-137	arginase, liver	Mus musculus	48-58
23030417-2	2012	Pin1 represents an enzyme that specifically catalyzes the isomerization of peptide bonds between phosphorylated threonine or serine residues and proline.	Proline	145-152	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
22762973-3	2012	hPRR2 has the prorenin-binding domain inserted between amino acid residues (81)Asp and (82)Pro of GP64.	Proline	91-94	nectin cell adhesion molecule 2	Homo sapiens	0-5
22740501-5	2012	The pressor response to the microinjection of L-Pro into the 3V was found to be mediated by circulating vasopressin, so, given that the paraventricular nucleus of the hypothalamus (PVN) is readily accessible from the 3V, we investigated whether the PVN could be a site of action for the L-Pro microinjected in the 3V.	Proline	46-51	arginine vasopressin	Rattus norvegicus	104-115
22740501-6	2012	The microinjection of L-Pro (0.033 mumoles/0.1 mul) into the PVN caused cardiovascular responses similar to those of injection of the 3V and were also shown to be mediated by vasopressin release.	Proline	22-27	arginine vasopressin	Rattus norvegicus	175-186
22740501-7	2012	In conclusion, these results show that the microinjection of L-Pro into the 3V causes pressor and bradycardiac responses that could involve stimulation of the magnocellular cells of the PVN and release of vasopressin into the systemic circulation.	Proline	61-66	arginine vasopressin	Rattus norvegicus	205-216
22740501-4	2012	Because the response to the microinjection of L-Pro into the 3V was blocked by intravenous pretreatment with the V1-vasopressin receptor antagonist dTyr(CH(2) )(5) (Me)AVP (50mug/kg), it is suggested that these cardiovascular responses are mediated by a vasopressin release.	Proline	46-51	arginine vasopressin	Rattus norvegicus	116-127
22740501-4	2012	Because the response to the microinjection of L-Pro into the 3V was blocked by intravenous pretreatment with the V1-vasopressin receptor antagonist dTyr(CH(2) )(5) (Me)AVP (50mug/kg), it is suggested that these cardiovascular responses are mediated by a vasopressin release.	Proline	46-51	arginine vasopressin	Rattus norvegicus	254-265
22966201-6	2012	Quantitative mass spectrometry analysis reveals that JNK phosphorylates 4E-T on six proline-directed sites that are required for the formation of the 4E-T complex upon stress.	Proline	84-91	mitogen-activated protein kinase 8	Homo sapiens	53-56
22966201-6	2012	Quantitative mass spectrometry analysis reveals that JNK phosphorylates 4E-T on six proline-directed sites that are required for the formation of the 4E-T complex upon stress.	Proline	84-91	eukaryotic translation initiation factor 4E nuclear import factor 1	Homo sapiens	72-76
22966201-6	2012	Quantitative mass spectrometry analysis reveals that JNK phosphorylates 4E-T on six proline-directed sites that are required for the formation of the 4E-T complex upon stress.	Proline	84-91	eukaryotic translation initiation factor 4E nuclear import factor 1	Homo sapiens	150-154
22922109-11	2012	Taking together, all these data suggest that StDREB2 takes part in the processes underlying plant responses to abiotic stresses probably via the regulation of ABA hormone signaling and through a mechanism allowing proline synthesis.	Proline	214-221	ethylene-responsive transcription factor ERF010-like	Solanum tuberosum	45-52
23071326-3	2012	SICKLE (SIC), a proline-rich protein critical for development and abiotic stress tolerance of Arabidopsis, was identified in this study.	Proline	16-23	hydroxyproline-rich glycoprotein family protein	Arabidopsis thaliana	0-3
22882974-6	2012	Analysis of essential elements for internalization established that proline-rich regions in the cytoplasmic domain of ADAM12, previously shown to interact with Src-homology 3 domains, were necessary for proper internalization.	Proline	68-75	ADAM metallopeptidase domain 12	Homo sapiens	118-124
23025283-6	2012	The common structural and electrostatic characteristics of Pin1 substrates, which contain a phosphorylated serine/threonine-proline motif, suggest that very rapid binding kinetics are a general feature of Pin1 interactions with other substrates.	Proline	124-131	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	59-63
23025283-6	2012	The common structural and electrostatic characteristics of Pin1 substrates, which contain a phosphorylated serine/threonine-proline motif, suggest that very rapid binding kinetics are a general feature of Pin1 interactions with other substrates.	Proline	124-131	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	205-209
22955849-1	2012	BACKGROUND: Prolyl hydroxylation is a post-translational modification that affects the structure, stability and function of proteins including collagen by catalysing hydroxylation of proline to hydroxyproline through action of collagen prolyl hydroxylases3 (C-P3H) and 4 (C-P4H).	Proline	183-190	complement C4A (Rodgers blood group)	Homo sapiens	258-270
22942284-7	2012	Surprisingly, we also observed a second binding interface between the two proteins that involves the Proline-Serine-Threonine rich (PST) repeats of MDC1 and the N-terminal non-core region of RAG1 (R1Nt).	Proline	101-108	mediator of DNA damage checkpoint 1	Homo sapiens	148-152
22942284-7	2012	Surprisingly, we also observed a second binding interface between the two proteins that involves the Proline-Serine-Threonine rich (PST) repeats of MDC1 and the N-terminal non-core region of RAG1 (R1Nt).	Proline	101-108	recombination activating 1	Homo sapiens	191-195
22795893-1	2012	Cyclin-dependent kinase, Cdk5, is an atypical but essential member of the Cdk family of proline-directed serine/threonine kinases with no evident role in cell cycle progression.	Proline	88-95	proliferating cell nuclear antigen	Homo sapiens	0-6
22795893-1	2012	Cyclin-dependent kinase, Cdk5, is an atypical but essential member of the Cdk family of proline-directed serine/threonine kinases with no evident role in cell cycle progression.	Proline	88-95	cyclin dependent kinase 5	Homo sapiens	25-29
22795893-1	2012	Cyclin-dependent kinase, Cdk5, is an atypical but essential member of the Cdk family of proline-directed serine/threonine kinases with no evident role in cell cycle progression.	Proline	88-95	cyclin dependent kinase 5	Homo sapiens	25-28
23062072-13	2012	Proline biosynthesis through P5CS2 and P5CR is limiting for vegetative and reproductive development in Arabidopsis, whereas disruption of P5CS1 alone does not affect development of non-stressed plants.	Proline	0-7	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	29-34
23062072-13	2012	Proline biosynthesis through P5CS2 and P5CR is limiting for vegetative and reproductive development in Arabidopsis, whereas disruption of P5CS1 alone does not affect development of non-stressed plants.	Proline	0-7	pyrroline-5- carboxylate (P5C) reductase	Arabidopsis thaliana	39-43
22915551-4	2012	p53 is a well-studied transcription factor that has a proline-rich N-terminal ID region containing two activation domains.	Proline	54-61	tumor protein p53	Homo sapiens	0-3
22915551-5	2012	High proline content is a property commonly associated with ID, and thus p53 may be a good model system for investigating the biochemical importance of ID.	Proline	5-12	tumor protein p53	Homo sapiens	73-76
22910912-0	2012	Proline-mediated proteasomal degradation of the prostate-specific tumor suppressor NKX3.1.	Proline	0-7	NK3 homeobox 1	Homo sapiens	83-89
23051937-11	2012	Expression analysis of stress responsive genes in SaSce9 Arabidopsis plants revealed the increased expression of antioxidant genes, AtSOD and AtCAT, ion antiporter genes, AtNHX1 and AtSOS1, a gene involved in proline biosynthesis, AtP5CS, and a gene involved in ABA dependent signaling pathway, AtRD22.	Proline	209-216	sodium proton exchanger, putative (NHX7) (SOS1)	Arabidopsis thaliana	182-188
23051937-11	2012	Expression analysis of stress responsive genes in SaSce9 Arabidopsis plants revealed the increased expression of antioxidant genes, AtSOD and AtCAT, ion antiporter genes, AtNHX1 and AtSOS1, a gene involved in proline biosynthesis, AtP5CS, and a gene involved in ABA dependent signaling pathway, AtRD22.	Proline	209-216	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	231-237
23062336-0	2012	Interaction of the S6 proline hinge with N-type and C-type inactivation in Kv1.4 channels.	Proline	22-29	potassium voltage-gated channel subfamily A member 4	Homo sapiens	75-80
23062336-2	2012	We studied the proline hinge in Kv1.4 channels, which inactivate via two mechanisms: N- and C-type.	Proline	15-22	potassium voltage-gated channel subfamily A member 4	Homo sapiens	32-37
23062340-1	2012	The proline-, glutamate-, valine-, and lysine-rich (PEVK) domain of the giant muscle protein titin is thought to be an intrinsically unstructured random-coil segment.	Proline	4-11	titin	Homo sapiens	93-98
22918858-6	2012	Contrary, cathepsin G was activated by IPP, VPP and LPP as well as the amino acids proline and isoleucine.	Proline	83-90	cathepsin G	Homo sapiens	10-21
22789442-7	2012	A systematic mutation analysis of all 17 Ser/Thr-Pro-motifs in Nur77 revealed that Pin1 enhances protein stability of Nur77 in an isomerase-dependent manner by acting on phosphorylated Nur77 involving protein kinase CK2-mediated phosphorylation of the Ser(152)-Pro(153) motif in Nur77.	Proline	49-52	nuclear receptor subfamily 4 group A member 1	Homo sapiens	63-68
22926288-1	2012	Proline-rich polypeptide complex (PRP) and its constituent nonapeptide (NP) possess immunoregulatory and procognitive properties.	Proline	0-7	prion protein	Homo sapiens	34-37
22789442-7	2012	A systematic mutation analysis of all 17 Ser/Thr-Pro-motifs in Nur77 revealed that Pin1 enhances protein stability of Nur77 in an isomerase-dependent manner by acting on phosphorylated Nur77 involving protein kinase CK2-mediated phosphorylation of the Ser(152)-Pro(153) motif in Nur77.	Proline	261-264	nuclear receptor subfamily 4 group A member 1	Homo sapiens	63-68
22789442-7	2012	A systematic mutation analysis of all 17 Ser/Thr-Pro-motifs in Nur77 revealed that Pin1 enhances protein stability of Nur77 in an isomerase-dependent manner by acting on phosphorylated Nur77 involving protein kinase CK2-mediated phosphorylation of the Ser(152)-Pro(153) motif in Nur77.	Proline	49-52	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	83-87
22789442-7	2012	A systematic mutation analysis of all 17 Ser/Thr-Pro-motifs in Nur77 revealed that Pin1 enhances protein stability of Nur77 in an isomerase-dependent manner by acting on phosphorylated Nur77 involving protein kinase CK2-mediated phosphorylation of the Ser(152)-Pro(153) motif in Nur77.	Proline	261-264	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	83-87
22789442-7	2012	A systematic mutation analysis of all 17 Ser/Thr-Pro-motifs in Nur77 revealed that Pin1 enhances protein stability of Nur77 in an isomerase-dependent manner by acting on phosphorylated Nur77 involving protein kinase CK2-mediated phosphorylation of the Ser(152)-Pro(153) motif in Nur77.	Proline	261-264	nuclear receptor subfamily 4 group A member 1	Homo sapiens	118-123
22789442-7	2012	A systematic mutation analysis of all 17 Ser/Thr-Pro-motifs in Nur77 revealed that Pin1 enhances protein stability of Nur77 in an isomerase-dependent manner by acting on phosphorylated Nur77 involving protein kinase CK2-mediated phosphorylation of the Ser(152)-Pro(153) motif in Nur77.	Proline	49-52	nuclear receptor subfamily 4 group A member 1	Homo sapiens	118-123
22789442-7	2012	A systematic mutation analysis of all 17 Ser/Thr-Pro-motifs in Nur77 revealed that Pin1 enhances protein stability of Nur77 in an isomerase-dependent manner by acting on phosphorylated Nur77 involving protein kinase CK2-mediated phosphorylation of the Ser(152)-Pro(153) motif in Nur77.	Proline	261-264	nuclear receptor subfamily 4 group A member 1	Homo sapiens	118-123
22789442-7	2012	A systematic mutation analysis of all 17 Ser/Thr-Pro-motifs in Nur77 revealed that Pin1 enhances protein stability of Nur77 in an isomerase-dependent manner by acting on phosphorylated Nur77 involving protein kinase CK2-mediated phosphorylation of the Ser(152)-Pro(153) motif in Nur77.	Proline	261-264	nuclear receptor subfamily 4 group A member 1	Homo sapiens	118-123
22789442-7	2012	A systematic mutation analysis of all 17 Ser/Thr-Pro-motifs in Nur77 revealed that Pin1 enhances protein stability of Nur77 in an isomerase-dependent manner by acting on phosphorylated Nur77 involving protein kinase CK2-mediated phosphorylation of the Ser(152)-Pro(153) motif in Nur77.	Proline	49-52	nuclear receptor subfamily 4 group A member 1	Homo sapiens	118-123
22789442-7	2012	A systematic mutation analysis of all 17 Ser/Thr-Pro-motifs in Nur77 revealed that Pin1 enhances protein stability of Nur77 in an isomerase-dependent manner by acting on phosphorylated Nur77 involving protein kinase CK2-mediated phosphorylation of the Ser(152)-Pro(153) motif in Nur77.	Proline	49-52	nuclear receptor subfamily 4 group A member 1	Homo sapiens	118-123
21898050-1	2012	Yeast Fpr4p belongs to the FK506-binding protein (FKBP) class of peptidyl proline isomerases (PPIases), and has been implicated in regulating the cis-trans conversion of proline residues within histone tails.	Proline	74-81	peptidylprolyl isomerase FPR4	Saccharomyces cerevisiae S288C	6-11
22674847-5	2012	On the basis of the obtained results we can conclude that proline residue at the hinge region makes cystatin C structure more flexible and dynamic, what probably facilitates the dimerization process of this hCC variant.	Proline	58-65	cystatin C	Homo sapiens	100-110
22577815-6	2012	Furthermore, the hPAT1-/rPAT1-mediated transport of gaboxadol or L-proline was studied in hPAT1-expressing Xenopus laevis oocytes, Caco-2 cell monolayers and excised segments of the rat intestine.	Proline	65-74	amyloid beta precursor protein binding protein 2	Rattus norvegicus	24-29
22577815-8	2012	The pharmacokinetics of gaboxadol were modified by the co-administration of L-tryptophan (an hPAT1 inhibitor) and L-proline (an hPAT1 substrate).	Proline	114-123	solute carrier family 36 member 1	Homo sapiens	128-133
22935697-2	2012	Itch contains four WW domains, which are essential for recognition on the target substrate, which contains a short proline-rich sequence.	Proline	115-122	itchy E3 ubiquitin protein ligase	Homo sapiens	0-4
22889087-0	2012	The proline-rich tetramerization peptides in equine serum butyrylcholinesterase.	Proline	4-11	butyrylcholinesterase	Equus caballus	58-79
23001182-5	2012	In bone marrow biopsies of the majority of tested patients with acute myeloid leukemia, HCLS1 protein expression is substantially elevated, associated with high levels of G-CSF synthesis and, in some individuals, a four-residue insertion in a proline-rich region of HCLS1 protein known to accelerate intracellular signaling.	Proline	243-250	hematopoietic cell-specific Lyn substrate 1	Homo sapiens	88-93
22915319-2	2012	ZmHyPRP is a proline-rich protein with a C-terminal domain having eight cysteines in a CM8 pattern.	Proline	13-20	uncharacterized protein LOC100283347	Zea mays	0-7
22944204-4	2012	The expression plasmid contained a gene fragment encoding the Tat-HA-NR2B9c was ligated to the C-terminal fragment of l-asparaginase (AnsB-C) via a unique acid labile Asp-Pro linker.	Proline	171-174	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	69-75
22944204-4	2012	The expression plasmid contained a gene fragment encoding the Tat-HA-NR2B9c was ligated to the C-terminal fragment of l-asparaginase (AnsB-C) via a unique acid labile Asp-Pro linker.	Proline	171-174	asparaginase and isoaspartyl peptidase 1	Homo sapiens	118-132
22577815-6	2012	Furthermore, the hPAT1-/rPAT1-mediated transport of gaboxadol or L-proline was studied in hPAT1-expressing Xenopus laevis oocytes, Caco-2 cell monolayers and excised segments of the rat intestine.	Proline	65-74	solute carrier family 36 member 1	Homo sapiens	17-22
22399314-10	2012	CLA isomers have different effects on metabolism in Ala and Pro carriers.	Proline	60-63	selectin P ligand	Homo sapiens	0-3
22717888-9	2012	Prolidase activity was determined by a photometric method based on the measurement of proline levels produced by prolidase.	Proline	86-93	peptidase D	Rattus norvegicus	0-9
22717888-9	2012	Prolidase activity was determined by a photometric method based on the measurement of proline levels produced by prolidase.	Proline	86-93	peptidase D	Rattus norvegicus	113-122
22674847-5	2012	On the basis of the obtained results we can conclude that proline residue at the hinge region makes cystatin C structure more flexible and dynamic, what probably facilitates the dimerization process of this hCC variant.	Proline	58-65	HCC	Homo sapiens	207-210
22766233-4	2012	We delineated a proline-rich motif within the cargo-binding domain of Kif26B to be responsible for this protein-protein interaction.	Proline	16-23	kinesin family member 26B	Homo sapiens	70-76
22885468-1	2012	Proline dehydrogenase (oxidase, PRODH/POX), the first enzyme in the pathway of proline catabolism, has been identified as a mitochondrial, metabolic tumor suppressor, which is downregulated in a variety of human tumors.	Proline	79-86	proline dehydrogenase 1	Homo sapiens	32-37
22947219-2	2012	A highly conserved central segment comprises a membrane-anchoring amphipathic alpha-helix followed by a proline-rich segment that represents a ligand for SH3 domain-containing proteins.	Proline	104-111	sperm hammerhead 3	Mus musculus	154-157
22790597-5	2012	Additionally, high-affinity Na(+)-dependent transport of L-proline, presumably via SIT1 (Slc6a20), was absent, whereas glucose uptake via SGLT1 (Slc5a1) was not affected.	Proline	57-66	suppression inducing transmembrane adaptor 1	Mus musculus	83-87
22790597-5	2012	Additionally, high-affinity Na(+)-dependent transport of L-proline, presumably via SIT1 (Slc6a20), was absent, whereas glucose uptake via SGLT1 (Slc5a1) was not affected.	Proline	57-66	solute carrier family 6 (neurotransmitter transporter), member 20B	Mus musculus	89-96
22993508-10	2012	Roughly at the middle of the S6 there exists a highly conserved glycine residue and a tandem proline motif that seem to fulfill the role of a gating hinge which allows for tilting/swiveling/rotations of the post-hinge S6 segment.	Proline	93-100	ribosomal protein S6	Homo sapiens	29-31
22993508-10	2012	Roughly at the middle of the S6 there exists a highly conserved glycine residue and a tandem proline motif that seem to fulfill the role of a gating hinge which allows for tilting/swiveling/rotations of the post-hinge S6 segment.	Proline	93-100	ribosomal protein S6	Homo sapiens	218-220
22829593-0	2012	The in vivo role of androgen receptor SUMOylation as revealed by androgen insensitivity syndrome and prostate cancer mutations targeting the proline/glycine residues of synergy control motifs.	Proline	141-148	androgen receptor	Homo sapiens	20-37
22829593-7	2012	Remarkably, several AR mutations associated with oligospermia and androgen insensitivity syndrome map to Pro-390, the conserved proline downstream of the first SC motif in AR.	Proline	128-135	androgen receptor	Homo sapiens	20-22
22843681-7	2012	Phosphorylation of GPSM3 by a proline-directed serine/threonine kinase and the resultant association of 14-3-3 is the first description of post-translational regulation of GPSM3 subcellular localization, a process that likely regulates important spatio-temporal aspects of G-protein-coupled receptor signaling modulation by GPSM3.	Proline	30-37	G protein signaling modulator 3	Homo sapiens	19-24
22843681-7	2012	Phosphorylation of GPSM3 by a proline-directed serine/threonine kinase and the resultant association of 14-3-3 is the first description of post-translational regulation of GPSM3 subcellular localization, a process that likely regulates important spatio-temporal aspects of G-protein-coupled receptor signaling modulation by GPSM3.	Proline	30-37	G protein signaling modulator 3	Homo sapiens	172-177
22843681-7	2012	Phosphorylation of GPSM3 by a proline-directed serine/threonine kinase and the resultant association of 14-3-3 is the first description of post-translational regulation of GPSM3 subcellular localization, a process that likely regulates important spatio-temporal aspects of G-protein-coupled receptor signaling modulation by GPSM3.	Proline	30-37	G protein signaling modulator 3	Homo sapiens	172-177
22889304-6	2012	The thiosemicarbazone-proline conjugates L- and D-Pro-STSC show only moderate cytotoxic potency with IC(50) values of 62 and 75 muM, respectively, in CH1 cells and &gt;100 muM in SW480 cells.	Proline	22-29	latexin	Homo sapiens	128-131
22889304-6	2012	The thiosemicarbazone-proline conjugates L- and D-Pro-STSC show only moderate cytotoxic potency with IC(50) values of 62 and 75 muM, respectively, in CH1 cells and &gt;100 muM in SW480 cells.	Proline	22-29	SUN domain containing ossification factor	Homo sapiens	150-153
22889304-6	2012	The thiosemicarbazone-proline conjugates L- and D-Pro-STSC show only moderate cytotoxic potency with IC(50) values of 62 and 75 muM, respectively, in CH1 cells and &gt;100 muM in SW480 cells.	Proline	22-29	latexin	Homo sapiens	172-175
22546504-1	2012	Prolyl oligopeptidase (PREP) cleaves short peptides at the C-side of proline.	Proline	69-76	prolyl endopeptidase	Rattus norvegicus	0-21
22546504-1	2012	Prolyl oligopeptidase (PREP) cleaves short peptides at the C-side of proline.	Proline	69-76	prolyl endopeptidase	Rattus norvegicus	23-27
22546504-2	2012	Although several proline containing neuropeptides have been shown to be efficiently cleaved by PREP in vitro, the actual physiological substrates of this peptidase are still a matter of controversy.	Proline	17-24	prolyl endopeptidase	Rattus norvegicus	95-99
22641691-5	2012	Coexpression of different Bat3 domain deletion constructs with YWK-II/APLP2 reveals that the proline-rich domain of Bat3 is required for its binding to YWK-II/APLP2.	Proline	93-100	BAG cochaperone 6	Homo sapiens	26-30
22641691-5	2012	Coexpression of different Bat3 domain deletion constructs with YWK-II/APLP2 reveals that the proline-rich domain of Bat3 is required for its binding to YWK-II/APLP2.	Proline	93-100	amyloid beta precursor like protein 2	Homo sapiens	70-75
22641691-5	2012	Coexpression of different Bat3 domain deletion constructs with YWK-II/APLP2 reveals that the proline-rich domain of Bat3 is required for its binding to YWK-II/APLP2.	Proline	93-100	BAG cochaperone 6	Homo sapiens	116-120
22641691-5	2012	Coexpression of different Bat3 domain deletion constructs with YWK-II/APLP2 reveals that the proline-rich domain of Bat3 is required for its binding to YWK-II/APLP2.	Proline	93-100	amyloid beta precursor like protein 2	Homo sapiens	159-164
22908330-4	2012	We find that differences in avidity for IGRP(206-214)/K(d) map to CDR1alpha and are associated with quantitative differences in CD3epsilon proline-rich sequence exposure and Nck recruitment.	Proline	139-146	glucose-6-phosphatase, catalytic, 2	Mus musculus	40-44
22908330-4	2012	We find that differences in avidity for IGRP(206-214)/K(d) map to CDR1alpha and are associated with quantitative differences in CD3epsilon proline-rich sequence exposure and Nck recruitment.	Proline	139-146	CD3 antigen, epsilon polypeptide	Mus musculus	128-138
23341755-3	2012	The common (non Gly, Pro) backbone CMAP potential has been refined against experimental solution NMR data for weakly structured peptides, resulting in a rebalancing of the energies of the alpha-helix and extended regions of the Ramachandran map, correcting the alpha-helical bias of CHARMM22/CMAP.	Proline	21-24	cystatin F	Homo sapiens	35-39
23341755-3	2012	The common (non Gly, Pro) backbone CMAP potential has been refined against experimental solution NMR data for weakly structured peptides, resulting in a rebalancing of the energies of the alpha-helix and extended regions of the Ramachandran map, correcting the alpha-helical bias of CHARMM22/CMAP.	Proline	21-24	cystatin F	Homo sapiens	292-296
22885468-1	2012	Proline dehydrogenase (oxidase, PRODH/POX), the first enzyme in the pathway of proline catabolism, has been identified as a mitochondrial, metabolic tumor suppressor, which is downregulated in a variety of human tumors.	Proline	79-86	proline dehydrogenase 1	Homo sapiens	38-41
22892239-0	2012	Serine phosphorylation and proline isomerization in RNAP II CTD control recruitment of Nrd1.	Proline	27-34	nardilysin convertase	Homo sapiens	87-91
22976962-5	2012	Our results clearly indicate that the isomerase Pin1 interacts favorably with pSer/pThr-Pro residues in Tau, but does not bind non-phosphorylated Tau or phospho-Tyr residues in Tau films.	Proline	88-91	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	48-52
22796327-0	2012	Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death.	Proline	39-46	proline dehydrogenase 1	Homo sapiens	0-21
22796327-2	2012	Proline is oxidized to glutamate in the mitochondria, with the rate-limiting step catalyzed by proline dehydrogenase (PRODH).	Proline	0-7	proline dehydrogenase 1	Homo sapiens	95-116
22796327-2	2012	Proline is oxidized to glutamate in the mitochondria, with the rate-limiting step catalyzed by proline dehydrogenase (PRODH).	Proline	0-7	proline dehydrogenase 1	Homo sapiens	118-123
22796327-3	2012	PRODH expression is inducible by p53, leading to increased proline oxidation, reactive oxygen species formation, and induction of apoptosis.	Proline	59-66	proline dehydrogenase 1	Homo sapiens	0-5
22796327-3	2012	PRODH expression is inducible by p53, leading to increased proline oxidation, reactive oxygen species formation, and induction of apoptosis.	Proline	59-66	tumor protein p53	Homo sapiens	33-36
22796327-7	2012	Inhibition or siRNA-mediated knockdown of PRODH abolished proline protection against oxidative stress, whereas knockdown of Delta(1)-pyrroline-5-carboxylate reductase, a key enzyme in proline biosynthesis, had no impact on proline protection.	Proline	58-65	proline dehydrogenase 1	Homo sapiens	42-47
22747514-2	2012	At the neuromuscular junction, AChE is mainly anchored in the extracellular matrix by the collagen Q, whereas in the brain, AChE is tethered by the proline-rich membrane anchor (PRiMA).	Proline	148-155	acetylcholinesterase	Mus musculus	124-128
22796327-9	2012	The combined inhibition of the mammalian target of rapamycin complex 1 (mTORC1) and mTORC2 eliminated proline protection.	Proline	102-109	CREB regulated transcription coactivator 1	Mus musculus	72-78
22796327-9	2012	The combined inhibition of the mammalian target of rapamycin complex 1 (mTORC1) and mTORC2 eliminated proline protection.	Proline	102-109	CREB regulated transcription coactivator 2	Mus musculus	84-90
22796327-10	2012	A significant increase in Akt activation was observed in proline-treated cells after hydrogen peroxide stress along with a corresponding increase in the phosphorylation of the forkhead transcription factor class O3a (FoxO3a).	Proline	57-64	AKT serine/threonine kinase 1	Homo sapiens	26-29
22796327-10	2012	A significant increase in Akt activation was observed in proline-treated cells after hydrogen peroxide stress along with a corresponding increase in the phosphorylation of the forkhead transcription factor class O3a (FoxO3a).	Proline	57-64	forkhead box O3	Homo sapiens	217-223
22796327-11	2012	The role of PRODH in proline-mediated protection was validated in the prostate carcinoma cell line PC3.	Proline	21-28	proline dehydrogenase 1	Homo sapiens	12-17
22796327-13	2012	The results provide evidence that PRODH is essential in proline protection against hydrogen peroxide-mediated cell death and that proline/PRODH helps activate Akt in cancer cells.	Proline	56-63	proline dehydrogenase 1	Homo sapiens	34-39
22796327-13	2012	The results provide evidence that PRODH is essential in proline protection against hydrogen peroxide-mediated cell death and that proline/PRODH helps activate Akt in cancer cells.	Proline	130-137	proline dehydrogenase 1	Homo sapiens	138-143
22796327-13	2012	The results provide evidence that PRODH is essential in proline protection against hydrogen peroxide-mediated cell death and that proline/PRODH helps activate Akt in cancer cells.	Proline	130-137	AKT serine/threonine kinase 1	Homo sapiens	159-162
23486661-5	2012	The proline rich Crk binding region of C3G and residues 90-525 of beta-catenin are sufficient for the interaction.	Proline	4-11	CRK proto-oncogene, adaptor protein	Homo sapiens	17-20
23486661-5	2012	The proline rich Crk binding region of C3G and residues 90-525 of beta-catenin are sufficient for the interaction.	Proline	4-11	Rap guanine nucleotide exchange factor 1	Homo sapiens	39-42
23486661-5	2012	The proline rich Crk binding region of C3G and residues 90-525 of beta-catenin are sufficient for the interaction.	Proline	4-11	catenin beta 1	Homo sapiens	66-78
22588130-7	2012	One missense mutation c.2909G>C on exon 21 of AGTPBP1 was discovered, which induces an Arg to Pro substitution (p.Arg970Pro) at amino-acid 970, a conserved residue for the catalytic activity of AGTPBP1.	Proline	94-97	ATP/GTP binding protein 1	Mus musculus	46-53
22588130-7	2012	One missense mutation c.2909G>C on exon 21 of AGTPBP1 was discovered, which induces an Arg to Pro substitution (p.Arg970Pro) at amino-acid 970, a conserved residue for the catalytic activity of AGTPBP1.	Proline	94-97	ATP/GTP binding protein 1	Mus musculus	194-201
22170564-1	2012	Delta(1)-Pyrroline-5-carboxylate synthetase (P5CS) catalyzes the first two steps of ornithine/proline biosynthesis.	Proline	94-101	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-43
22170564-1	2012	Delta(1)-Pyrroline-5-carboxylate synthetase (P5CS) catalyzes the first two steps of ornithine/proline biosynthesis.	Proline	94-101	aldehyde dehydrogenase 18 family member A1	Homo sapiens	45-49
22170564-3	2012	Only one family exhibited metabolic changes consistent with P5CS deficiency (low proline/ornithine/citrulline/arginine; fasting hyperammonemia).	Proline	81-88	aldehyde dehydrogenase 18 family member A1	Homo sapiens	60-64
22842228-6	2012	Crystal structures, and biochemical and functional studies of RAC1(P29S) showed that the alteration releases the conformational restraint conferred by the conserved proline, causes an increased binding of the protein to downstream effectors, and promotes melanocyte proliferation and migration.	Proline	165-172	Rac family small GTPase 1	Homo sapiens	62-66
21863385-9	2012	DNA sequencing results showed that there were two single nucleotide polymorphisms, distributed in exon 6 (NM_002532.3:c.1044G&gt;A (ACG-ACA, Thr   Thr) and exon 10 (NM_002532.3:c.1389A&gt;T, CCA-CCT, Pro   Pro).	Proline	200-203	CCT	Homo sapiens	195-198
22903472-5	2012	A non-significant trend towards a good pathological response was shown in patients carrying the Arg/Arg or Arg/Pro TP53 codon 72 gene variant compared to those harboring the Pro/Pro variant (17.6 or 37.9 % vs. 0; p = 0.071).	Proline	111-114	tumor protein p53	Homo sapiens	115-119
22811526-10	2012	The evolution of HEV PPR, in contrast with that of the rest of the nonstructural polyprotein, is molded by pressures that lead toward increased proline usage with a corresponding decrease in the usage of aromatic amino acids, favoring formation of IDR structures.	Proline	144-151	polyprotein	Orthohepevirus A	81-92
22707198-3	2012	To understand the molecular mechanisms by which cyclo (His-Pro) (CHP) affects amelioration of diabetes mellitus, we performed gene expression profiling in the pancreatic tissues of two diabetic animal models, streptozocin (STZ)-induced diabetic rats (T1DM) and genetically-diabetic (C57BL/6J ob/ob) mice (T2DM).	Proline	59-62	ras homolog family member V	Rattus norvegicus	65-68
22560112-5	2012	Importantly, these findings further highlight the importance of the proline residues located in the conserved domains of the ubiquilin-2 protein, suggesting that mutations affecting these residues are particularly relevant to the development of ALS.	Proline	68-75	ubiquilin 2	Homo sapiens	125-136
22729983-1	2012	Prolyl oligopeptidase (PREP) is an intracellular enzyme digesting small proline-containing peptides.	Proline	72-79	prolyl endopeptidase	Rattus norvegicus	0-21
22729983-1	2012	Prolyl oligopeptidase (PREP) is an intracellular enzyme digesting small proline-containing peptides.	Proline	72-79	prolyl endopeptidase	Rattus norvegicus	23-27
22820152-5	2012	Transgenic tobacco of overexpressing ZmMPK4 accumulated less reactive oxygen species (ROS), more peroxidase and catalase activities, more proline and soluble sugar contents, and more stress-responsive genes expression, leading to enhancing low temperature stress tolerance compared to the control plants.	Proline	138-145	Mitogen-activated protein kinase 5	Zea mays	37-43
22824424-7	2012	Chlorophyll a fluorescence analyses indicate a possible lack of intact Oxygen Evolving Complexes (OECs) in MSP antisense plants, which allow access to internal non-water electron donors (e.g., ascorbate and proline) and consequently increase the Photosystem II (PSII) activity of those plants.	Proline	207-214	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	107-110
22767602-8	2012	Dyrk1A (dual specificity tyrosine-phosphorylated and regulated kinase 1A) interacted with SRp55 and mainly phosphorylated its proline-rich domain.	Proline	126-133	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	0-6
22857010-2	2012	Previously, we have shown that DYRK1A, a chromosome 21-encoded kinase implicated in the mental retardation of Down syndrome, phosphorylates primarily serine 857 (S857) in the proline-rich domain, found only in 1xa, one of the alternative C-terminal splicing isoforms of dynamin 1.	Proline	175-182	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	31-37
22782901-4	2012	Known small molecule MIF inhibitors typically bind in the tautomerase site of the MIF trimer, often covalently modifying the catalytic proline.	Proline	135-142	macrophage migration inhibitory factor	Homo sapiens	21-24
22782901-4	2012	Known small molecule MIF inhibitors typically bind in the tautomerase site of the MIF trimer, often covalently modifying the catalytic proline.	Proline	135-142	macrophage migration inhibitory factor	Homo sapiens	82-85
22857010-2	2012	Previously, we have shown that DYRK1A, a chromosome 21-encoded kinase implicated in the mental retardation of Down syndrome, phosphorylates primarily serine 857 (S857) in the proline-rich domain, found only in 1xa, one of the alternative C-terminal splicing isoforms of dynamin 1.	Proline	175-182	dynamin 1	Homo sapiens	270-279
22664385-2	2012	The classical BCL2L12 protein isoform contains a highly conserved BH2 domain, a BH3-like motif, and a proline-rich region, and is involved in apoptosis.	Proline	102-109	BCL2 like 12	Homo sapiens	14-21
22936936-5	2012	Our recent study resolved these questions by demonstrating that the unique V3 (hinge) domain of PKCtheta and, more specifically, a proline-rich motif within this domain, is essential and sufficient for its localization at the IS, where it is anchored to the cytoplasmic tail of CD28 via an indirect mechanism involving Lck protein tyrosine kinase (PTK) as an intermediate.	Proline	131-138	CD28 molecule	Homo sapiens	278-282
22936936-5	2012	Our recent study resolved these questions by demonstrating that the unique V3 (hinge) domain of PKCtheta and, more specifically, a proline-rich motif within this domain, is essential and sufficient for its localization at the IS, where it is anchored to the cytoplasmic tail of CD28 via an indirect mechanism involving Lck protein tyrosine kinase (PTK) as an intermediate.	Proline	131-138	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	319-322
22561447-1	2012	BACKGROUND: Dipeptidyl peptidase 4 (DP4) is a serine protease that preferentially cleaves N-terminal dipeptides from polypeptides containing proline or alanine as the penultimate amino acid.	Proline	141-148	dipeptidyl peptidase 4	Homo sapiens	12-34
22561447-1	2012	BACKGROUND: Dipeptidyl peptidase 4 (DP4) is a serine protease that preferentially cleaves N-terminal dipeptides from polypeptides containing proline or alanine as the penultimate amino acid.	Proline	141-148	dipeptidyl peptidase 4	Homo sapiens	36-39
22722938-3	2012	DAT is phosphorylated by protein kinase C within a serine cluster at the distal end of the cytoplasmic N terminus, whereas recent work in model cells revealed proline-directed phosphorylation of rat DAT at membrane-proximal residue Thr(53).	Proline	159-166	solute carrier family 6 member 3	Rattus norvegicus	199-202
22847422-2	2012	A distinctive structural feature of all collagen types is a unique triple-helical structure formed by tandem repeats of the consensus sequence Xaa-Yaa-Gly, in which Xaa and Yaa frequently are proline and hydroxyproline, respectively.	Proline	192-199	accelerated autoimmunity and lymphoproliferation transposition	Mus musculus	147-150
22847422-2	2012	A distinctive structural feature of all collagen types is a unique triple-helical structure formed by tandem repeats of the consensus sequence Xaa-Yaa-Gly, in which Xaa and Yaa frequently are proline and hydroxyproline, respectively.	Proline	192-199	accelerated autoimmunity and lymphoproliferation transposition	Mus musculus	173-176
22863195-10	2012	This suggests that five amino acids (Met-Ala-Leu-Glu-Pro) are added to the N terminus and alter IFITM5 function in individuals with the mutation.	Proline	53-56	interferon induced transmembrane protein 5	Homo sapiens	96-102
22052810-2	2012	A single nucleotide polymorphism of TP53 encoding either arginine or proline at codon 72 is suggested to alter in vitro p53 behavior.	Proline	69-76	tumor protein p53	Homo sapiens	36-40
22892315-2	2012	Although studies in vitro have suggested that the mutant htt can act in a potentially dominant negative fashion by sequestering wild-type htt into insoluble protein aggregates, the role of the length of the normal htt polyQ stretch, and the adjacent proline-rich region (PRR) in modulating HD mouse model pathogenesis is currently unknown.	Proline	250-257	huntingtin	Mus musculus	57-60
22512465-0	2012	Prolidase function in proline metabolism and its medical and biotechnological applications.	Proline	22-29	peptidase D	Homo sapiens	0-9
22512465-1	2012	Prolidase is a multifunctional enzyme that possesses the unique ability to degrade imidodipeptides in which a proline or hydroxyproline residue is located at the C-terminal end.	Proline	110-117	peptidase D	Homo sapiens	0-9
22750213-0	2012	N-linked glycosylation of proline-rich membrane anchor (PRiMA) is not required for assembly and trafficking of globular tetrameric acetylcholinesterase.	Proline	26-33	proline rich membrane anchor 1	Mus musculus	56-61
22750213-1	2012	Acetylcholinesterase (AChE) is organized into globular tetramers (G(4)) by a structural protein called proline-rich membrane anchor (PRiMA), anchoring it into the cell membrane of neurons in the brain.	Proline	103-110	acetylcholinesterase	Mus musculus	0-20
22750213-1	2012	Acetylcholinesterase (AChE) is organized into globular tetramers (G(4)) by a structural protein called proline-rich membrane anchor (PRiMA), anchoring it into the cell membrane of neurons in the brain.	Proline	103-110	acetylcholinesterase	Mus musculus	22-26
22750213-1	2012	Acetylcholinesterase (AChE) is organized into globular tetramers (G(4)) by a structural protein called proline-rich membrane anchor (PRiMA), anchoring it into the cell membrane of neurons in the brain.	Proline	103-110	proline rich membrane anchor 1	Mus musculus	133-138
22868769-3	2012	The 1.5 A resolution crystal structure of a complex between the SH3 domain of the Fyn tyrosine kinase and the C-terminal proline-rich motif of the NS5A-derived peptide APPIPPPRRKR has been solved.	Proline	121-128	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
22868769-7	2012	The proline-rich motif present in the NS5A protein seems to be important for RNA replication and virus assembly, and the promiscuous interaction of the Fyn SH3 domain with the NS5A C-terminal proline-rich peptide found in this crystallographic structure may be important in the virus infection cycle.	Proline	4-11	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	152-155
22868769-7	2012	The proline-rich motif present in the NS5A protein seems to be important for RNA replication and virus assembly, and the promiscuous interaction of the Fyn SH3 domain with the NS5A C-terminal proline-rich peptide found in this crystallographic structure may be important in the virus infection cycle.	Proline	192-199	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	152-155
22315494-0	2012	CBL mutations in myeloproliferative neoplasms are also found in the gene"s proline-rich domain and in patients with the V617FJAK2.	Proline	75-82	Cbl proto-oncogene	Homo sapiens	0-3
22315494-7	2012	RESULTS: An initial screening of all coding exons of CBL, CBLB and CBLC in 44 V617FJAK2-negative samples revealed two new CBL mutations (p.C416W in the RING finger domain and p.A678V in the proline-rich domain).	Proline	190-197	Cbl proto-oncogene	Homo sapiens	53-56
22315494-7	2012	RESULTS: An initial screening of all coding exons of CBL, CBLB and CBLC in 44 V617FJAK2-negative samples revealed two new CBL mutations (p.C416W in the RING finger domain and p.A678V in the proline-rich domain).	Proline	190-197	Cbl proto-oncogene C	Homo sapiens	67-71
22578594-5	2012	In this study, we found that N-acetyltransferase Mpr1 that detoxifies the proline analog azetidine-2-carboxylate in Saccharomyces cerevisiae also converts CHOP into N-acetyl CHOP in vitro and in vivo.	Proline	74-81	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	49-53
22732588-4	2012	Like Themis1, Themis2, a related member of the Themis family, which is expressed in B cells and macrophages, contains two conserved cysteine-based domains, a proline-rich region, and a nuclear localization signal.	Proline	158-165	thymocyte selection associated family member 2	Mus musculus	14-21
22492707-7	2012	Moreover, we provide evidence that the RSfp (rodent Sfr1 proline rich) motif in Sfr1 serves as a negative regulatory element.	Proline	57-64	SWI5 dependent recombination repair 1	Mus musculus	52-56
22492707-7	2012	Moreover, we provide evidence that the RSfp (rodent Sfr1 proline rich) motif in Sfr1 serves as a negative regulatory element.	Proline	57-64	SWI5 dependent recombination repair 1	Mus musculus	80-84
22569528-6	2012	ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of substrates containing a Pro-Xxx-Ser/Thr-Pro sequence.	Proline	112-115	mitogen-activated protein kinase 3	Homo sapiens	0-6
22052810-2	2012	A single nucleotide polymorphism of TP53 encoding either arginine or proline at codon 72 is suggested to alter in vitro p53 behavior.	Proline	69-76	tumor protein p53	Homo sapiens	120-123
22812534-1	2012	INTRODUCTION: The estrogen receptor (ER) co-regulator proline glutamic acid and leucine-rich protein 1 (PELP1) is a proto-oncogene that modulates epigenetic changes on ER target gene promoters via interactions with lysine-specific histone demethylase 1 (KDM1).	Proline	54-61	proline, glutamate and leucine rich protein 1	Homo sapiens	104-109
22858677-1	2012	The largest subunit of RNA polymerase (pol) II, Rpb1, contains an unusual carboxyl-terminal domain (CTD) composed of consecutive repeats of the sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser (Y 1S 2P 3T 4S 5P 6S 7).	Proline	161-164	RNA polymerase II subunit A	Homo sapiens	48-52
22414890-2	2012	The aims of this study were to determine the frequency of the Arg/Pro SNP in p53 in Thoroughbred mares on one stud in Brazil and to correlate p53 genotypes with reproductive performance.	Proline	66-69	tumor protein p53	Equus caballus	77-80
22684237-1	2012	A diastereo- and enantioselective aldol reaction between aldehydes and a synthetically useful ketomalonate 1c as a hydrated form was developed, and either anti- or syn-aldol adducts having a chiral tetrasubstituted carbon center were obtained in high enantioselectivities by use of a tetrazole analogue of L-proline (S)-2 or an axially chiral amino sulfonamide (S)-3 as catalyst.	Proline	306-315	synemin	Homo sapiens	73-76
22685171-7	2012	Interestingly, altered accumulation of metabolites, including proline and malondialdehyde, was also observed in nrt1.5 plants.	Proline	62-69	nitrate transporter 1.1	Arabidopsis thaliana	112-116
22249977-0	2012	Impact of codon 72 Arg &gt; Pro single nucleotide polymorphism in TP53 gene in the risk of kangri cancer: a case control study in Kashmir.	Proline	28-31	tumor protein p53	Homo sapiens	66-70
22750443-0	2012	Comparative analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein alpha.	Proline	62-69	prolyl endopeptidase	Homo sapiens	95-116
22750443-0	2012	Comparative analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein alpha.	Proline	62-69	fibroblast activation protein alpha	Homo sapiens	121-156
22778397-0	2012	Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).	Proline	72-79	FUS RNA binding protein	Homo sapiens	124-148
22778397-0	2012	Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).	Proline	72-79	FUS RNA binding protein	Homo sapiens	150-153
22778397-1	2012	Mutations in the proline/tyrosine-nuclear localization signal (PY-NLS) of the Fused in Sarcoma protein (FUS) cause amyotrophic lateral sclerosis (ALS).	Proline	17-24	FUS RNA binding protein	Homo sapiens	78-102
22778397-1	2012	Mutations in the proline/tyrosine-nuclear localization signal (PY-NLS) of the Fused in Sarcoma protein (FUS) cause amyotrophic lateral sclerosis (ALS).	Proline	17-24	FUS RNA binding protein	Homo sapiens	104-107
22750006-8	2012	To address which domain of Osx is responsible for VEGF regulation, the deletion mutant analysis and transfection assay were carried out to show that proline-rich region (PRR) is required for Osx activation of VEGF promoter activity.	Proline	149-156	Sp7 transcription factor 7	Mus musculus	27-30
22750006-8	2012	To address which domain of Osx is responsible for VEGF regulation, the deletion mutant analysis and transfection assay were carried out to show that proline-rich region (PRR) is required for Osx activation of VEGF promoter activity.	Proline	149-156	vascular endothelial growth factor A	Mus musculus	50-54
22750006-8	2012	To address which domain of Osx is responsible for VEGF regulation, the deletion mutant analysis and transfection assay were carried out to show that proline-rich region (PRR) is required for Osx activation of VEGF promoter activity.	Proline	149-156	Sp7 transcription factor 7	Mus musculus	191-194
22750006-8	2012	To address which domain of Osx is responsible for VEGF regulation, the deletion mutant analysis and transfection assay were carried out to show that proline-rich region (PRR) is required for Osx activation of VEGF promoter activity.	Proline	149-156	vascular endothelial growth factor A	Mus musculus	209-213
22812534-1	2012	INTRODUCTION: The estrogen receptor (ER) co-regulator proline glutamic acid and leucine-rich protein 1 (PELP1) is a proto-oncogene that modulates epigenetic changes on ER target gene promoters via interactions with lysine-specific histone demethylase 1 (KDM1).	Proline	54-61	lysine demethylase 1A	Homo sapiens	215-252
22812534-1	2012	INTRODUCTION: The estrogen receptor (ER) co-regulator proline glutamic acid and leucine-rich protein 1 (PELP1) is a proto-oncogene that modulates epigenetic changes on ER target gene promoters via interactions with lysine-specific histone demethylase 1 (KDM1).	Proline	54-61	lysine demethylase 1A	Homo sapiens	254-258
22609800-1	2012	Proline is a readily released stress substrate that can be metabolized by proline oxidase (POX) to generate either reactive oxygen species (ROS) to induce apoptosis or autophagy or ATP during times of nutrient stress.	Proline	0-7	proline dehydrogenase 1	Homo sapiens	74-89
22609800-1	2012	Proline is a readily released stress substrate that can be metabolized by proline oxidase (POX) to generate either reactive oxygen species (ROS) to induce apoptosis or autophagy or ATP during times of nutrient stress.	Proline	0-7	proline dehydrogenase 1	Homo sapiens	91-94
22609800-7	2012	Under low-glucose and combined low-glucose and hypoxic conditions, proline catabolized by POX was used preferentially for ATP production, whereas under hypoxia, POX mediated autophagic signaling for survival by generating ROS.	Proline	67-74	proline dehydrogenase 1	Homo sapiens	90-93
22773562-3	2012	Chloramines of proline, arginine, and glycine caused significant damage to PCNA in cells.	Proline	15-22	proliferating cell nuclear antigen	Homo sapiens	75-79
22506990-6	2012	Interference with Homer function by introduction of the synthetic PPKKFR peptide into cells, which emulates the proline-rich sequences of the PPXXF motif, reduced STIM1-Orai1 and TRPC1- IP3RII associations, as compared with the introduction of the inactive PPKKRR peptide.	Proline	112-119	stromal interaction molecule 1	Homo sapiens	163-168
22506990-6	2012	Interference with Homer function by introduction of the synthetic PPKKFR peptide into cells, which emulates the proline-rich sequences of the PPXXF motif, reduced STIM1-Orai1 and TRPC1- IP3RII associations, as compared with the introduction of the inactive PPKKRR peptide.	Proline	112-119	ORAI calcium release-activated calcium modulator 1	Homo sapiens	169-174
22506990-6	2012	Interference with Homer function by introduction of the synthetic PPKKFR peptide into cells, which emulates the proline-rich sequences of the PPXXF motif, reduced STIM1-Orai1 and TRPC1- IP3RII associations, as compared with the introduction of the inactive PPKKRR peptide.	Proline	112-119	transient receptor potential cation channel subfamily C member 1	Homo sapiens	179-184
22402276-3	2012	The predicted trout LAMP3 shares the characteristic features of LAMP family members such as a C-terminal lysosomal sorting motif (G-Y-D-R-I) in the short C-terminal cytoplasmic tail, typical for lysosomal targeting, four potential N-linked glycosylation sites (NXS/T), four conserved cysteines in the membrane-proximal domain and the luminal domain divided by a serine/proline-rich region.	Proline	369-376	lysosomal associated membrane protein 3	Gallus gallus	20-25
22566698-0	2012	Group A streptococcus adheres to pharyngeal epithelial cells with salivary proline-rich proteins via GrpE chaperone protein.	Proline	75-82	GrpE like 1, mitochondrial	Homo sapiens	101-105
22454527-4	2012	Cdc14 colocalizes with Inn1 at the cell division site and interacts with the C-terminal proline-rich domain of Inn1 that mediates its binding to the SH3-domain-containing proteins Hof1 and Cyk3.	Proline	88-95	phosphoprotein phosphatase CDC14	Saccharomyces cerevisiae S288C	0-5
22454527-4	2012	Cdc14 colocalizes with Inn1 at the cell division site and interacts with the C-terminal proline-rich domain of Inn1 that mediates its binding to the SH3-domain-containing proteins Hof1 and Cyk3.	Proline	88-95	Inn1p	Saccharomyces cerevisiae S288C	111-115
22454527-4	2012	Cdc14 colocalizes with Inn1 at the cell division site and interacts with the C-terminal proline-rich domain of Inn1 that mediates its binding to the SH3-domain-containing proteins Hof1 and Cyk3.	Proline	88-95	formin-binding protein HOF1	Saccharomyces cerevisiae S288C	180-184
22454527-4	2012	Cdc14 colocalizes with Inn1 at the cell division site and interacts with the C-terminal proline-rich domain of Inn1 that mediates its binding to the SH3-domain-containing proteins Hof1 and Cyk3.	Proline	88-95	Cyk3p	Saccharomyces cerevisiae S288C	189-193
22483234-8	2012	We noted that the favorable histology Wilms tumors with a proline residue at position 72 of TP53 tended to have higher immunoexpression of GLUT1, although this immunoexpression did not reach statistical significance in this small set of cases.	Proline	58-65	tumor protein p53	Homo sapiens	92-96
22483234-8	2012	We noted that the favorable histology Wilms tumors with a proline residue at position 72 of TP53 tended to have higher immunoexpression of GLUT1, although this immunoexpression did not reach statistical significance in this small set of cases.	Proline	58-65	solute carrier family 2 member 1	Homo sapiens	139-144
22528483-3	2012	However, the majority of eukaryotic proline racemase-like proteins, including a human protein called C14orf149, lack a specific cysteine residue that is known to be critical for racemase activity.	Proline	36-43	trans-L-3-hydroxyproline dehydratase	Homo sapiens	101-110
22488046-7	2012	The proline residue, in position 4 of the bradykinin sequence promotes a turn in the longer peptide chain, shortening its end-to-end distance.	Proline	4-11	kininogen 1	Homo sapiens	42-52
22642896-3	2012	DNA from 104 acute myeloid leukemia patients was tested for mutations in 12 exons encoding 3 major functional domains of DNMT3A: the PWWP (proline-tryptophan-tryptophan-proline) domain (exons 8 to 10), the ADD (ATM-DNMT3-DNMT3L) zinc finger, and the methyltransferase domains encoded by exons 15 to 23.	Proline	139-146	DNA methyltransferase 3 alpha	Homo sapiens	121-127
22356895-9	2012	In contrast, the predictive utility of the 72 Arg/Pro SNP in p53 requires mutational analysis of p53, limiting its routine clinical use.	Proline	50-53	tumor protein p53	Homo sapiens	61-64
22356895-9	2012	In contrast, the predictive utility of the 72 Arg/Pro SNP in p53 requires mutational analysis of p53, limiting its routine clinical use.	Proline	50-53	tumor protein p53	Homo sapiens	97-100
22589548-2	2012	To test this hypothesis directly in vivo, we generated a knock-in mouse line with targeted mutation of the Ca(v)beta(2) gene by insertion of a stop codon after proline 501 in exon 14 (mouse sequence Cacnb2; betaStop mouse).	Proline	160-167	calcium channel, voltage-dependent, beta 2 subunit	Mus musculus	107-118
22577147-4	2012	Although the two proteins have been proposed to display the four conserved phosphorylation sites originally identified in stathmin 1, we show here that they possess distinct phosphorylation sites within their specific proline-rich domains (PRDs) that are differentially regulated by phosphorylation by proline-directed kinases involved in the control of neuronal differentiation.	Proline	218-225	stathmin 1	Homo sapiens	122-132
22577147-4	2012	Although the two proteins have been proposed to display the four conserved phosphorylation sites originally identified in stathmin 1, we show here that they possess distinct phosphorylation sites within their specific proline-rich domains (PRDs) that are differentially regulated by phosphorylation by proline-directed kinases involved in the control of neuronal differentiation.	Proline	302-309	stathmin 1	Homo sapiens	122-132
22737668-5	2012	The discovery that proline degradation is activated by p53 directed our attention to the initiation of apoptosis by proline oxidase/dehydrogenase.	Proline	19-26	tumor protein p53	Homo sapiens	55-58
22726689-3	2012	Nox2 activation depends on the binding of the proline-rich domain of its heterodimeric partner p22phox to p47phox.	Proline	46-53	cytochrome b-245, beta polypeptide	Mus musculus	0-4
22726689-3	2012	Nox2 activation depends on the binding of the proline-rich domain of its heterodimeric partner p22phox to p47phox.	Proline	46-53	dynein cytoplasmic 1 heavy chain 1	Mus musculus	95-98
22726689-3	2012	Nox2 activation depends on the binding of the proline-rich domain of its heterodimeric partner p22phox to p47phox.	Proline	46-53	neutrophil cytosolic factor 1	Mus musculus	106-113
22641034-4	2012	We demonstrate that Hck SH3 recognizes an extended linear proline-rich region of Alix.	Proline	58-65	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
22641034-4	2012	We demonstrate that Hck SH3 recognizes an extended linear proline-rich region of Alix.	Proline	58-65	programmed cell death 6 interacting protein	Homo sapiens	81-85
22737668-6	2012	Now, however, we find that the biosynthetic mechanisms and the metabolic interlock may depend on the pathway from glutamine to proline, and it is markedly activated by the oncogene MYC.	Proline	127-134	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	181-184
22705789-3	2012	A ternary, cooperative interaction clamps the MHC-I CD into a narrow binding groove at the Nef-mu1 interface, which encompasses the cargo-recognition site of mu1 and the proline-rich strand of Nef.	Proline	170-177	S100 calcium binding protein B	Homo sapiens	91-94
22570300-1	2012	We replaced the amino terminal Pro residue of the Plk1 polo-box-domain-binding pentapeptide (PLHSpT) with a library of N-alkyl-Gly "peptoids", and identified long-chain tethered phenyl moieties giving greater than two-orders-of-magnitude affinity enhancement.	Proline	31-34	polo like kinase 1	Homo sapiens	50-54
22621321-4	2012	In addition, the concepts of proximity-driven catalysis are extended to include modification of the natural Fyn SH3 domain with metallopeptides based on a known proline-rich peptide ligand.	Proline	161-168	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	108-111
22705789-3	2012	A ternary, cooperative interaction clamps the MHC-I CD into a narrow binding groove at the Nef-mu1 interface, which encompasses the cargo-recognition site of mu1 and the proline-rich strand of Nef.	Proline	170-177	glutathione S-transferase mu 1	Homo sapiens	95-98
22705789-3	2012	A ternary, cooperative interaction clamps the MHC-I CD into a narrow binding groove at the Nef-mu1 interface, which encompasses the cargo-recognition site of mu1 and the proline-rich strand of Nef.	Proline	170-177	glutathione S-transferase mu 1	Homo sapiens	158-161
22705789-3	2012	A ternary, cooperative interaction clamps the MHC-I CD into a narrow binding groove at the Nef-mu1 interface, which encompasses the cargo-recognition site of mu1 and the proline-rich strand of Nef.	Proline	170-177	S100 calcium binding protein B	Homo sapiens	193-196
22006429-7	2012	Notably, multiple mutations were identified in phosphoinositide-3-kinase (PI3K), catalytic, alpha polypeptide (PIK3CA) (H1047R, E lysine at codon 545 [E545K], and H proline at codon 701 [H701P]) that were not observed previously in osteosarcoma.	Proline	165-172	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	111-117
22366451-7	2012	By a structure-function approach, we demonstrate that two proline-rich motifs (P4/5) within Gab1 are essential for invadopodia formation.	Proline	58-65	GRB2 associated binding protein 1	Homo sapiens	92-96
21744012-2	2012	In both prokaryotic and eukaryotic microorganisms, unless an ornithine cyclodeaminase is present, the activity of delta1-pyrroline-5-carboxylate (P5C) reductase is mandatory to proline production, and the enzyme inhibition should result in amino acid starvation, blocking in turn protein synthesis.	Proline	177-184	pyrroline-5-carboxylate reductase 1	Homo sapiens	146-149
22454507-1	2012	A proline to serine mutation (P56S) in vesicle-associated membrane protein-associated protein B and C (VAPB) causes an autosomal dominant form of amyotrophic lateral sclerosis (ALS).	Proline	2-9	VAMP associated protein B and C	Homo sapiens	103-107
22458656-2	2012	In addition to cognate proline, prolyl-tRNA synthetase (ProRS) can activate cysteine and alanine and misacylate tRNA(Pro).	Proline	23-30	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	56-61
22002310-1	2012	Pin1 regulates a subset of phosphoproteins by isomerizing phospho-Ser/Thr-Pro motifs via a "post-phosphorylation" mechanism.	Proline	74-77	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
22002310-3	2012	There are at least three phospho-Ser-Pro motifs on TR3 that bind to Pin1.	Proline	37-40	nuclear receptor subfamily 4 group A member 1	Homo sapiens	51-54
22002310-3	2012	There are at least three phospho-Ser-Pro motifs on TR3 that bind to Pin1.	Proline	37-40	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	68-72
22615385-0	2012	Intron-mediated alternative splicing of Arabidopsis P5CS1 and its association with natural variation in proline and climate adaptation.	Proline	104-111	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	52-57
22615385-2	2012	Proline accumulation of the Arabidopsis accession Shakdara (Sha) was threefold less than that of Landsberg erecta (Ler) and quantitative trait loci mapping identified a reduced function allele of the proline synthesis enzyme Delta(1)-pyrroline-5-carboxylate synthetase1 (P5CS1) as a basis for the lower proline of Sha.	Proline	0-7	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	225-269
22615385-2	2012	Proline accumulation of the Arabidopsis accession Shakdara (Sha) was threefold less than that of Landsberg erecta (Ler) and quantitative trait loci mapping identified a reduced function allele of the proline synthesis enzyme Delta(1)-pyrroline-5-carboxylate synthetase1 (P5CS1) as a basis for the lower proline of Sha.	Proline	0-7	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	271-276
22615385-2	2012	Proline accumulation of the Arabidopsis accession Shakdara (Sha) was threefold less than that of Landsberg erecta (Ler) and quantitative trait loci mapping identified a reduced function allele of the proline synthesis enzyme Delta(1)-pyrroline-5-carboxylate synthetase1 (P5CS1) as a basis for the lower proline of Sha.	Proline	200-207	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	225-269
22615385-2	2012	Proline accumulation of the Arabidopsis accession Shakdara (Sha) was threefold less than that of Landsberg erecta (Ler) and quantitative trait loci mapping identified a reduced function allele of the proline synthesis enzyme Delta(1)-pyrroline-5-carboxylate synthetase1 (P5CS1) as a basis for the lower proline of Sha.	Proline	200-207	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	271-276
22615385-2	2012	Proline accumulation of the Arabidopsis accession Shakdara (Sha) was threefold less than that of Landsberg erecta (Ler) and quantitative trait loci mapping identified a reduced function allele of the proline synthesis enzyme Delta(1)-pyrroline-5-carboxylate synthetase1 (P5CS1) as a basis for the lower proline of Sha.	Proline	303-310	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	225-269
22615385-5	2012	In a larger panel of Arabidopsis accessions, low water potential-induced proline accumulation varied by 10-fold and variable production of exon 3-skip P5CS1 among accessions was an important, but not the sole, factor underlying variation in proline accumulation.	Proline	241-248	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	151-156
22615385-7	2012	These data identify a unique source of alternative splicing in plants, demonstrate a role of exon 3-skip P5CS1 in natural variation of proline metabolism, and suggest an association of P5CS1 and its alternative splicing with environmental adaptation.	Proline	135-142	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	105-110
22615385-7	2012	These data identify a unique source of alternative splicing in plants, demonstrate a role of exon 3-skip P5CS1 in natural variation of proline metabolism, and suggest an association of P5CS1 and its alternative splicing with environmental adaptation.	Proline	135-142	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	185-190
22615405-0	2012	Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.	Proline	17-24	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	151-156
22615405-3	2012	Less well-recognized, glutamate can also be converted to proline through Delta(1)-pyrroline-5-carboxylate (P5C) and vice versa.	Proline	57-64	pyrroline-5-carboxylate reductase 1	Homo sapiens	73-105
22615405-4	2012	This study suggests that some MYC-induced cellular effects are due to MYC regulation of proline metabolism.	Proline	88-95	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	30-33
22615405-4	2012	This study suggests that some MYC-induced cellular effects are due to MYC regulation of proline metabolism.	Proline	88-95	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	70-73
22615405-5	2012	Proline oxidase, also known as proline dehydrogenase (POX/PRODH), the first enzyme in proline catabolism, is a mitochondrial tumor suppressor that inhibits proliferation and induces apoptosis.	Proline	31-38	proline dehydrogenase 1	Homo sapiens	54-57
22615405-5	2012	Proline oxidase, also known as proline dehydrogenase (POX/PRODH), the first enzyme in proline catabolism, is a mitochondrial tumor suppressor that inhibits proliferation and induces apoptosis.	Proline	31-38	proline dehydrogenase 1	Homo sapiens	58-63
22615405-10	2012	Interestingly, MYC not only inhibited POX/PRODH, but also markedly increased the enzymes of proline biosynthesis from glutamine, including P5C synthase and P5C reductase 1.	Proline	92-99	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	15-18
22615405-10	2012	Interestingly, MYC not only inhibited POX/PRODH, but also markedly increased the enzymes of proline biosynthesis from glutamine, including P5C synthase and P5C reductase 1.	Proline	92-99	pyrroline-5-carboxylate reductase 1	Homo sapiens	156-171
22615405-11	2012	MYC-induced proline biosynthesis from glutamine was directly confirmed using (13)C,(15)N-glutamine as a tracer.	Proline	12-19	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-3
22615405-12	2012	The metabolic link between glutamine and proline afforded by MYC emphasizes the complexity of tumor metabolism.	Proline	41-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	61-64
22387225-2	2012	Recently, regulation of STIM1 by glycosylation and phosphorylation on serine/threonine or proline residues has been described; however other modes of phosphorylation that are important for activating SOCE in platelets, such as tyrosine phosphorylation, have been poorly investigated.	Proline	90-97	stromal interaction molecule 1	Homo sapiens	24-29
22561452-4	2012	This mechanism is dependent on a multidomain scaffolding protein, Preso1, that binds mGluR, Homer and proline-directed kinases and that is required for their phosphorylation of mGluR at the Homer binding site.	Proline	102-109	FERM and PDZ domain containing 4	Mus musculus	66-72
22536782-2	2012	Herein, using an array of biophysical techniques, we show that, whereas Grb2 exists in a monomer-dimer equilibrium, the proline-rich (PR) domain of Gab1 is a monomer in solution.	Proline	120-127	GRB2 associated binding protein 1	Homo sapiens	148-152
22647861-6	2012	In summary, we report a novel mutation, not previously described, in ANKH exon 1, wherein serine replaces proline, in a case of early-onset severe CPPD associated with metabolic abnormalities, with similar findings in the proband"s father.	Proline	106-113	ANKH inorganic pyrophosphate transport regulator	Homo sapiens	69-73
22437941-0	2012	Identification of the P-body component PATL1 as a novel ALG-2-interacting protein by in silico and far-Western screening of proline-rich proteins.	Proline	124-131	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	56-61
22350156-5	2012	The expressions of AtP5CS and AtZAT12 which mirror the activities of proline and ascorbate peroxidase synthesis respectively were induced in TaMYB33 over-expression lines, indicating TaMYB33 promotes the ability for osmotic pressure balance-reconstruction and reactive oxidative species (ROS) scavenging.	Proline	69-76	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	19-25
22350156-5	2012	The expressions of AtP5CS and AtZAT12 which mirror the activities of proline and ascorbate peroxidase synthesis respectively were induced in TaMYB33 over-expression lines, indicating TaMYB33 promotes the ability for osmotic pressure balance-reconstruction and reactive oxidative species (ROS) scavenging.	Proline	69-76	transcription factor MYB30	Triticum aestivum	141-148
22350156-5	2012	The expressions of AtP5CS and AtZAT12 which mirror the activities of proline and ascorbate peroxidase synthesis respectively were induced in TaMYB33 over-expression lines, indicating TaMYB33 promotes the ability for osmotic pressure balance-reconstruction and reactive oxidative species (ROS) scavenging.	Proline	69-76	transcription factor MYB30	Triticum aestivum	183-190
22561452-6	2012	Preso1 creates a microdomain for proline-directed kinases with broad substrate specificity to phosphorylate mGluR and to mediate negative regulation.	Proline	33-40	FERM and PDZ domain containing 4	Mus musculus	0-6
22744179-4	2012	The foa1 mutant exhibited a lower germination rate, shorter root length, more stomatal opening, increased proline accumulation and hypersensitivity to ABA compared with the wild type.	Proline	106-113	F-box and associated interaction domains-containing protein	Arabidopsis thaliana	4-8
22646706-10	2012	At the metabolic level, the contents of fructose, galactose and glucose were increased and decreased in the wild-type and TPS1 transgenic leaves, respectively, while the amounts of proline, inositol and raffinose were highly increased in both the wild-type and TPS1 transgenic leaves under drought conditions.	Proline	181-188	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	122-126
22424133-7	2012	The degradation of HIF-1alpha is regulated by hydroxylation of the 402/504 proline residue by PHDs.	Proline	75-82	hypoxia inducible factor 1, alpha subunit	Mus musculus	19-29
22646706-13	2012	The substantial increases in proline, inositol and raffinose contents detected in both the wild-type and TPS1 transgenic leaves appears to be a general response of potatoes to drought stress.	Proline	29-36	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	105-109
22563811-7	2012	A local, less dense negatively charged cluster on the surface of camel chymosin may weaken electrostatic binding to the His-Pro cluster of kappa-CN to simultaneously impart reduced substrate affinity and accelerated enzyme-substrate dissociation as compared to bovine chymosin.	Proline	124-127	chymosin	Camelus bactrianus	71-79
22361732-5	2012	The latter is followed by generation of polyamines by ornithine decarboxylase (ODC) and L-proline (L-Pro) by ornithine aminotransferase (OAT).	Proline	88-97	ornithine aminotransferase	Mus musculus	109-135
22447928-12	2012	Together, these data indicate that the proline-rich Src homology 3 domain-binding motif in TRAF6 interacts directly with activated SFKs to couple LPS engagement of TLR4 to SFK activation and loss of barrier integrity in HMVEC-Ls.	Proline	39-46	TNF receptor associated factor 6	Homo sapiens	91-96
22447928-12	2012	Together, these data indicate that the proline-rich Src homology 3 domain-binding motif in TRAF6 interacts directly with activated SFKs to couple LPS engagement of TLR4 to SFK activation and loss of barrier integrity in HMVEC-Ls.	Proline	39-46	toll like receptor 4	Homo sapiens	164-168
22447928-12	2012	Together, these data indicate that the proline-rich Src homology 3 domain-binding motif in TRAF6 interacts directly with activated SFKs to couple LPS engagement of TLR4 to SFK activation and loss of barrier integrity in HMVEC-Ls.	Proline	39-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	131-134
22506673-8	2012	Lastly, point mutations at position 132 of Cav1(62-178) (P132A, P132I, P132V, P132G, P132W, P132F) revealed that no other hydrophobic amino acid can preserve the monomeric state of Cav1(62-178), which indicates that proline 132 is critical in supporting proper caveolin-1 behavior.	Proline	216-223	caveolin 1	Homo sapiens	43-47
22486203-3	2012	We report here both syn- and anti-selective asymmetric direct Mannich reactions of N-protected aminoacetaldehydes with N-Boc-protected imines catalyzed by proline and the axially chiral amino sulfonamide (S)-3.	Proline	155-162	synemin	Homo sapiens	20-23
22486203-3	2012	We report here both syn- and anti-selective asymmetric direct Mannich reactions of N-protected aminoacetaldehydes with N-Boc-protected imines catalyzed by proline and the axially chiral amino sulfonamide (S)-3.	Proline	155-162	BOC cell adhesion associated, oncogene regulated	Homo sapiens	121-124
22361732-12	2012	L-Orn or L-Pro restored restitution in cells treated with BEC or Arg1 shRNA, whereas the polyamine putrescine had no benefit.	Proline	9-14	arginase, liver	Mus musculus	65-69
22651890-4	2012	We hypothesized that any Nef-SH3 domain interactions would be lost upon mutation of the prolines or arginine of PXXPXR.	Proline	88-96	S100 calcium binding protein B	Homo sapiens	25-28
22651890-6	2012	RESULTS: We found that mutations of either of the prolines or the arginine of PXXPXR are defective for Nef-Hck binding, Nef/activated PAK2 complex formation and enhancement of virion infectivity (EVI).	Proline	50-58	S100 calcium binding protein B	Homo sapiens	103-106
22651890-6	2012	RESULTS: We found that mutations of either of the prolines or the arginine of PXXPXR are defective for Nef-Hck binding, Nef/activated PAK2 complex formation and enhancement of virion infectivity (EVI).	Proline	50-58	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	107-110
22651890-6	2012	RESULTS: We found that mutations of either of the prolines or the arginine of PXXPXR are defective for Nef-Hck binding, Nef/activated PAK2 complex formation and enhancement of virion infectivity (EVI).	Proline	50-58	S100 calcium binding protein B	Homo sapiens	120-123
22651890-6	2012	RESULTS: We found that mutations of either of the prolines or the arginine of PXXPXR are defective for Nef-Hck binding, Nef/activated PAK2 complex formation and enhancement of virion infectivity (EVI).	Proline	50-58	p21 (RAC1) activated kinase 2	Homo sapiens	134-138
22640469-11	2012	The high chymotrypsin and elastase II quantities could allow recycling of proline-rich proteins.	Proline	74-81	chymotrypsin-like elastase family member 2A	Bos taurus	26-37
22500641-3	2012	Modified prolines with aromatic groups syn to the carboxylic acid are better catalysts than those with small hydrophobic groups (1a is 43.5 times faster than 1f).	Proline	9-17	synemin	Homo sapiens	39-42
22525314-3	2012	The inhibitors displayed inhibitory potency in the micromolar to nanomolar range and showed good to excellent selectivity with respect to the proline selective dipeptidyl peptidases (DPPs) DPP IV, DPP9 and DPP II.	Proline	142-149	dipeptidyl peptidase 4	Homo sapiens	189-195
22525314-3	2012	The inhibitors displayed inhibitory potency in the micromolar to nanomolar range and showed good to excellent selectivity with respect to the proline selective dipeptidyl peptidases (DPPs) DPP IV, DPP9 and DPP II.	Proline	142-149	dipeptidyl peptidase 9	Homo sapiens	197-201
22525314-3	2012	The inhibitors displayed inhibitory potency in the micromolar to nanomolar range and showed good to excellent selectivity with respect to the proline selective dipeptidyl peptidases (DPPs) DPP IV, DPP9 and DPP II.	Proline	142-149	dipeptidyl peptidase 7	Homo sapiens	206-212
22441125-5	2012	The result from yeast two hybrid assay showed that the C terminus of GalNAc-T14 (408-552aa) was essential for the interaction between GalNAc-T14 and IGFBP-3, especially Tyr(408), Pro(409), and Glu(410) of GalNAc-T14 may play key roles in the interaction with IGFBP-3.	Proline	179-182	polypeptide N-acetylgalactosaminyltransferase 14	Homo sapiens	69-79
22441125-5	2012	The result from yeast two hybrid assay showed that the C terminus of GalNAc-T14 (408-552aa) was essential for the interaction between GalNAc-T14 and IGFBP-3, especially Tyr(408), Pro(409), and Glu(410) of GalNAc-T14 may play key roles in the interaction with IGFBP-3.	Proline	179-182	polypeptide N-acetylgalactosaminyltransferase 14	Homo sapiens	134-144
22441125-5	2012	The result from yeast two hybrid assay showed that the C terminus of GalNAc-T14 (408-552aa) was essential for the interaction between GalNAc-T14 and IGFBP-3, especially Tyr(408), Pro(409), and Glu(410) of GalNAc-T14 may play key roles in the interaction with IGFBP-3.	Proline	179-182	insulin like growth factor binding protein 3	Homo sapiens	149-156
22441125-5	2012	The result from yeast two hybrid assay showed that the C terminus of GalNAc-T14 (408-552aa) was essential for the interaction between GalNAc-T14 and IGFBP-3, especially Tyr(408), Pro(409), and Glu(410) of GalNAc-T14 may play key roles in the interaction with IGFBP-3.	Proline	179-182	polypeptide N-acetylgalactosaminyltransferase 14	Homo sapiens	134-144
22441125-5	2012	The result from yeast two hybrid assay showed that the C terminus of GalNAc-T14 (408-552aa) was essential for the interaction between GalNAc-T14 and IGFBP-3, especially Tyr(408), Pro(409), and Glu(410) of GalNAc-T14 may play key roles in the interaction with IGFBP-3.	Proline	179-182	insulin like growth factor binding protein 3	Homo sapiens	259-266
22447928-8	2012	A cell-permeable decoy peptide corresponding to the same proline-rich motif reduced SFK binding to WT GST-TRAF6 compared with the Pro   Ala-substituted peptide.	Proline	57-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	84-87
22447928-8	2012	A cell-permeable decoy peptide corresponding to the same proline-rich motif reduced SFK binding to WT GST-TRAF6 compared with the Pro   Ala-substituted peptide.	Proline	57-64	TNF receptor associated factor 6	Homo sapiens	106-111
22252010-7	2012	Leptin also inhibited 1 mm proline and beta-alanine uptake in Na(+) medium at pH 6, conditions for optimal activity of the H(+) -dependent neutral amino acid transporter PAT1.	Proline	27-34	leptin	Homo sapiens	0-6
22361732-5	2012	The latter is followed by generation of polyamines by ornithine decarboxylase (ODC) and L-proline (L-Pro) by ornithine aminotransferase (OAT).	Proline	99-104	ornithine aminotransferase	Mus musculus	109-135
22677788-3	2012	Our previous work indicated a role of neuronal AKAP79/150 in the membrane targeting of Ca(V)1.2 L-type calcium channels, which involved a proline rich domain (PRD) in the intracellular II-III loop of the channel.	Proline	138-145	A-kinase anchoring protein 5	Homo sapiens	47-53
22289149-4	2012	Depletion of the M1-binding protein RACK1 also impairs virus release and RACK1 binding requires the proline residue at position 16 of M1.	Proline	100-107	receptor for activated C kinase 1	Homo sapiens	36-41
22289149-4	2012	Depletion of the M1-binding protein RACK1 also impairs virus release and RACK1 binding requires the proline residue at position 16 of M1.	Proline	100-107	receptor for activated C kinase 1	Homo sapiens	73-78
22289149-5	2012	The impaired M1-RACK1 interaction does not affect the plasma membrane binding of M1; in contrast, RACK1 is recruited to detergent-resistant membranes in a M1-proline-16-dependent manner.	Proline	158-165	receptor for activated C kinase 1	Homo sapiens	98-103
22677788-3	2012	Our previous work indicated a role of neuronal AKAP79/150 in the membrane targeting of Ca(V)1.2 L-type calcium channels, which involved a proline rich domain (PRD) in the intracellular II-III loop of the channel.	Proline	138-145	immunoglobulin lambda variable 2-8	Homo sapiens	87-95
21502183-5	2012	CONCLUSION: These data prove for increased pro-CPA and CPA levels as a biomarker for the diagnosis of pancreatitis and pancreatic cancer.	Proline	23-26	carboxypeptidase A1	Homo sapiens	47-50
22223757-4	2012	With the HDGF HATH domain used as a model, residue K19 was the most critical basic residue in molecular recognition and protein internalization, and with its proximal proline-tryptophan-tryptophan-proline motif, coordinated a conformational change when binding to the heparin fragment.	Proline	167-174	heparin binding growth factor	Homo sapiens	9-13
22223757-4	2012	With the HDGF HATH domain used as a model, residue K19 was the most critical basic residue in molecular recognition and protein internalization, and with its proximal proline-tryptophan-tryptophan-proline motif, coordinated a conformational change when binding to the heparin fragment.	Proline	197-204	heparin binding growth factor	Homo sapiens	9-13
21502183-5	2012	CONCLUSION: These data prove for increased pro-CPA and CPA levels as a biomarker for the diagnosis of pancreatitis and pancreatic cancer.	Proline	23-26	carboxypeptidase A1	Homo sapiens	55-58
22222112-3	2012	The deduced GhAGP31 protein contains the conserved features of non-classical AGPs: a putative signal peptide, N-terminal histidine-rich stretch, middle repetitive proline-rich domain and a cysteine-containing "PAC" domain.	Proline	163-170	non-classical arabinogalactan protein 31-like	Gossypium hirsutum	12-19
22438540-6	2012	We also showed that the PSAP motif interacts with the host protein tumor suppressor gene 101 (TSG101) and that altering any proline within the PSAP motif disrupts this interaction.	Proline	124-131	tumor susceptibility 101	Homo sapiens	67-92
22438540-6	2012	We also showed that the PSAP motif interacts with the host protein tumor suppressor gene 101 (TSG101) and that altering any proline within the PSAP motif disrupts this interaction.	Proline	124-131	tumor susceptibility 101	Homo sapiens	94-100
22438540-6	2012	We also showed that the PSAP motif interacts with the host protein tumor suppressor gene 101 (TSG101) and that altering any proline within the PSAP motif disrupts this interaction.	Proline	124-131	prosaposin	Homo sapiens	143-147
22496350-6	2012	We further perform PKD1 target motif analysis, showing that a proline residue at position +1 relative to the phosphorylation site serves as an inhibitory cue for PKD1 activity.	Proline	62-69	polycystin 1, transient receptor potential channel interacting	Homo sapiens	19-23
22496350-6	2012	We further perform PKD1 target motif analysis, showing that a proline residue at position +1 relative to the phosphorylation site serves as an inhibitory cue for PKD1 activity.	Proline	62-69	polycystin 1, transient receptor potential channel interacting	Homo sapiens	162-166
22287628-3	2012	By gauging the ability of mutants of Msl5 to complement msl5Delta, we find that the Mud2-binding (amino acids 35-54) and putative Prp40-binding (PPxY(100)) elements of the Msl5 N-terminal domain are inessential, as are the C-terminal proline-rich domain (amino acids 382-476) and two zinc-binding CxxCxxxxHxxxxC motifs (amino acids 273-286 and 299-312).	Proline	234-241	mRNA splicing protein MSL5	Saccharomyces cerevisiae S288C	37-41
22287628-3	2012	By gauging the ability of mutants of Msl5 to complement msl5Delta, we find that the Mud2-binding (amino acids 35-54) and putative Prp40-binding (PPxY(100)) elements of the Msl5 N-terminal domain are inessential, as are the C-terminal proline-rich domain (amino acids 382-476) and two zinc-binding CxxCxxxxHxxxxC motifs (amino acids 273-286 and 299-312).	Proline	234-241	mRNA splicing protein MSL5	Saccharomyces cerevisiae S288C	172-176
22280966-3	2012	In order to enhance the freeze tolerance of yeast cells, we constructed a self-cloning diploid baker"s yeast strain with simultaneous accumulation of proline, by expressing the PRO1-I150T allele, encoding the proline-feedback inhibition-less sensitive gamma-glutamyl kinase, and trehalose, by disrupting the NTH1 gene, encoding neutral trehalase.	Proline	209-216	glutamate 5-kinase	Saccharomyces cerevisiae S288C	177-181
22280966-3	2012	In order to enhance the freeze tolerance of yeast cells, we constructed a self-cloning diploid baker"s yeast strain with simultaneous accumulation of proline, by expressing the PRO1-I150T allele, encoding the proline-feedback inhibition-less sensitive gamma-glutamyl kinase, and trehalose, by disrupting the NTH1 gene, encoding neutral trehalase.	Proline	209-216	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	308-312
22345441-8	2012	The two prolines (P310 and P341 of Japanese fulminant hepatitis 1 [JFH-1]) contained in these motifs, as well as a conserved tryptophan in the spacer region, were required for CyPA binding, HCV replication, and CPI resistance.	Proline	8-16	peptidylprolyl isomerase A	Homo sapiens	176-180
22345441-9	2012	Together, these data provide a high-resolution mapping of proline residues important for CyPA binding and identify critical amino acids modulating HCV susceptibility to the clinical CPI Alisporivir.	Proline	58-65	peptidylprolyl isomerase A	Homo sapiens	89-93
22419821-6	2012	Moreover, IGPR-1, through its proline-rich cytoplasmic domain, associates with multiple Src homology 3 (SH3)-containing signaling proteins, including SH3 protein interacting with Nck (SPIN90/WISH), bullous pemphigoid antigen-1, and calcium channel beta2.	Proline	30-37	transmembrane and immunoglobulin domain containing 2	Homo sapiens	10-16
22411408-3	2012	Unlike other members of the Deltex family of proteins, DTX3L lacks the highly basic N-terminal motif and the central proline-rich motif present in other Deltex proteins, and instead contains other unique N-terminal domains.	Proline	117-124	deltex E3 ubiquitin ligase 3L	Homo sapiens	55-60
22537596-3	2012	By studying the functionality of a series of nef alleles from clinical isolates, we identified a dysfunctional HIV group O Nef in which a highly conserved valine-glycine-phenylalanine (VGF) region, which links a preceding acidic cluster with the following proline-rich motif into an amphipathic surface was deleted.	Proline	256-263	S100 calcium binding protein B	Homo sapiens	45-48
22403409-6	2012	Using in vitro binding assays, we show that PP2A/Balpha binds to MAP2c isoforms through a region encompassing the microtubule-binding domain and upstream proline-rich region.	Proline	154-161	protein phosphatase 2 phosphatase activator	Homo sapiens	44-55
22403409-6	2012	Using in vitro binding assays, we show that PP2A/Balpha binds to MAP2c isoforms through a region encompassing the microtubule-binding domain and upstream proline-rich region.	Proline	154-161	microtubule associated protein 2	Homo sapiens	65-70
22403409-8	2012	Remarkably, the protein-tyrosine kinase Fyn, which binds to the proline-rich RTPPKSP motif conserved in both MAP2 and tau, inhibits the interaction of PP2A/Balpha with either tau or MAP2c.	Proline	64-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	40-43
22403409-8	2012	Remarkably, the protein-tyrosine kinase Fyn, which binds to the proline-rich RTPPKSP motif conserved in both MAP2 and tau, inhibits the interaction of PP2A/Balpha with either tau or MAP2c.	Proline	64-71	microtubule associated protein 2	Homo sapiens	109-113
22403409-8	2012	Remarkably, the protein-tyrosine kinase Fyn, which binds to the proline-rich RTPPKSP motif conserved in both MAP2 and tau, inhibits the interaction of PP2A/Balpha with either tau or MAP2c.	Proline	64-71	protein phosphatase 2 phosphatase activator	Homo sapiens	151-155
22403409-8	2012	Remarkably, the protein-tyrosine kinase Fyn, which binds to the proline-rich RTPPKSP motif conserved in both MAP2 and tau, inhibits the interaction of PP2A/Balpha with either tau or MAP2c.	Proline	64-71	microtubule associated protein 2	Homo sapiens	182-187
22537596-3	2012	By studying the functionality of a series of nef alleles from clinical isolates, we identified a dysfunctional HIV group O Nef in which a highly conserved valine-glycine-phenylalanine (VGF) region, which links a preceding acidic cluster with the following proline-rich motif into an amphipathic surface was deleted.	Proline	256-263	S100 calcium binding protein B	Homo sapiens	123-126
22537596-3	2012	By studying the functionality of a series of nef alleles from clinical isolates, we identified a dysfunctional HIV group O Nef in which a highly conserved valine-glycine-phenylalanine (VGF) region, which links a preceding acidic cluster with the following proline-rich motif into an amphipathic surface was deleted.	Proline	256-263	VGF nerve growth factor inducible	Homo sapiens	185-188
22537596-10	2012	At the molecular level, the VGF motif was required for the physical interaction of the adjacent proline-rich motif with Hck.	Proline	96-103	VGF nerve growth factor inducible	Homo sapiens	28-31
22537596-10	2012	At the molecular level, the VGF motif was required for the physical interaction of the adjacent proline-rich motif with Hck.	Proline	96-103	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	120-123
22537596-11	2012	CONCLUSION: Based on these findings, we propose that this highly conserved three amino acid VGF motif together with the acidic cluster and the proline-rich motif form a previously unrecognized amphipathic surface on Nef.	Proline	143-150	VGF nerve growth factor inducible	Homo sapiens	92-95
22537596-11	2012	CONCLUSION: Based on these findings, we propose that this highly conserved three amino acid VGF motif together with the acidic cluster and the proline-rich motif form a previously unrecognized amphipathic surface on Nef.	Proline	143-150	S100 calcium binding protein B	Homo sapiens	216-219
22439849-0	2012	Interaction of the histone mRNA hairpin with stem-loop binding protein (SLBP) and regulation of the SLBP-RNA complex by phosphorylation and proline isomerization.	Proline	140-147	stem-loop binding protein	Homo sapiens	72-76
22534133-8	2012	A point mutation in the proline-rich site of Vav1, which abolishes its binding to Nck, impaired actin rearrangement, suggesting that Nck-Vav1 dimers play a critical role in regulation of the actin machinery.	Proline	24-31	vav guanine nucleotide exchange factor 1	Homo sapiens	45-49
22534133-8	2012	A point mutation in the proline-rich site of Vav1, which abolishes its binding to Nck, impaired actin rearrangement, suggesting that Nck-Vav1 dimers play a critical role in regulation of the actin machinery.	Proline	24-31	NCK adaptor protein 1	Homo sapiens	82-85
22534133-8	2012	A point mutation in the proline-rich site of Vav1, which abolishes its binding to Nck, impaired actin rearrangement, suggesting that Nck-Vav1 dimers play a critical role in regulation of the actin machinery.	Proline	24-31	NCK adaptor protein 1	Homo sapiens	133-136
22534133-8	2012	A point mutation in the proline-rich site of Vav1, which abolishes its binding to Nck, impaired actin rearrangement, suggesting that Nck-Vav1 dimers play a critical role in regulation of the actin machinery.	Proline	24-31	vav guanine nucleotide exchange factor 1	Homo sapiens	137-141
22439849-0	2012	Interaction of the histone mRNA hairpin with stem-loop binding protein (SLBP) and regulation of the SLBP-RNA complex by phosphorylation and proline isomerization.	Proline	140-147	stem-loop binding protein	Homo sapiens	100-104
22439849-8	2012	We show that the SLBP-histone mRNA complex is regulated by threonine phosphorylation and proline isomerization in a conserved TPNK sequence that lies between the two binding sites.	Proline	89-96	stem-loop binding protein	Homo sapiens	17-21
22218591-6	2012	Further delineation of this interaction by GST pull-down experiments utilizing different Dab2 constructs identified proline-rich domain as the interacting partner.	Proline	116-123	DAB adaptor protein 2	Homo sapiens	89-93
22407921-8	2012	The myristoylation and proline-rich motif of Nef were responsible for the observed signaling activation.	Proline	23-30	S100 calcium binding protein B	Homo sapiens	45-48
22507528-9	2012	A partial effect on canonical NF-kappaB signaling and an association with the A20 ubiquitin-editing protein complex was observed with mutagenesis of the PPxY motif, a proline-rich region involved in Nedd4-like protein interactions.	Proline	167-174	nuclear factor kappa B subunit 1	Homo sapiens	30-39
22445753-7	2012	More detailed analyses showed that substituting the Thr(130)-Val(131) sequence in the RAMP3 TMD with the corresponding sequence (Ile(157)-Pro(158)) from RAMP2 significantly enhanced AM-mediated CLR internalization.	Proline	138-141	receptor activity modifying protein 3	Homo sapiens	86-91
22318721-4	2012	The regulation by Pin1 requires both the catalytic activity of the isomerase and the presence of a Pro immediately following the phosphorylated Thr of the turn motif phosphorylation site, one of two C-terminal sites that is phosphorylated during the maturation of PKC isozymes.	Proline	99-102	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	18-22
22445753-7	2012	More detailed analyses showed that substituting the Thr(130)-Val(131) sequence in the RAMP3 TMD with the corresponding sequence (Ile(157)-Pro(158)) from RAMP2 significantly enhanced AM-mediated CLR internalization.	Proline	138-141	receptor activity modifying protein 2	Homo sapiens	153-158
22445753-7	2012	More detailed analyses showed that substituting the Thr(130)-Val(131) sequence in the RAMP3 TMD with the corresponding sequence (Ile(157)-Pro(158)) from RAMP2 significantly enhanced AM-mediated CLR internalization.	Proline	138-141	calcitonin receptor like receptor	Homo sapiens	194-197
22500761-3	2012	PQBP-1 binds specifically to glutamine repeat sequences and proline-rich regions, and interacts with RNA polymerase II and the spliceosomal protein U5-15kD.	Proline	60-67	polyglutamine binding protein 1	Homo sapiens	0-6
22649785-4	2012	Proline hydroxylation on key sites of HIFalpha provides the binding signal for pVHL E3 ligase complex.	Proline	0-7	von Hippel-Lindau tumor suppressor	Homo sapiens	79-83
22334671-7	2012	In plants, prolines in certain classes of proteins are hydroxylated and further substituted with plant-specific O-glycosylation; unsubstituted hydroxyprolines were identified in our MUC1 construct.	Proline	11-19	mucin 1, cell surface associated	Homo sapiens	182-186
22448726-5	2012	To clarify the inherent role of the carboxy terminus in the oligomerization and fibrillation of SAA, we truncated the proline-rich final 13 residues of SAA2.2.	Proline	118-125	serum amyloid A cluster	Mus musculus	96-99
22448726-5	2012	To clarify the inherent role of the carboxy terminus in the oligomerization and fibrillation of SAA, we truncated the proline-rich final 13 residues of SAA2.2.	Proline	118-125	serum amyloid A 2	Mus musculus	152-156
21287358-2	2012	HPK1 is a member of the Ste20-related kinase family, which contains four proline-rich sequences and is constitutively associated with HS1 in hematopoietic cells.	Proline	73-80	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	0-4
21647661-4	2012	Both CD-1 mice and spider monkeys displayed a higher olfactory sensitivity with the L- and D-forms of cysteine and methionine than with the prolines, suggesting an important role of the sulfur-containing functional groups for detectability.	Proline	140-148	CD1 antigen complex	Mus musculus	5-9
26952950-2	2012	A well-known polymorphism encoding the substitution of leucine to proline in the signal peptide sequence of NPY (Leu7Pro variation) was previously found to protect against depression.	Proline	66-73	neuropeptide Y	Homo sapiens	108-111
21287358-3	2012	Recombinant fusion protein GST-SH3(HS1) was expressed to assess the binding properties of 16 peptides derived from the HPK1 proline-rich regions.	Proline	124-131	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	119-123
22342556-4	2012	2D (1)H nuclear magnetic resonance analysis of full-length HIV-1 p6 and p6 peptides established that cyclophilin A (CypA) interacts as a peptidyl-prolyl cis/trans isomerase with all proline residues of p6.	Proline	182-189	peptidylprolyl isomerase A	Homo sapiens	101-114
22342556-4	2012	2D (1)H nuclear magnetic resonance analysis of full-length HIV-1 p6 and p6 peptides established that cyclophilin A (CypA) interacts as a peptidyl-prolyl cis/trans isomerase with all proline residues of p6.	Proline	182-189	peptidylprolyl isomerase A	Homo sapiens	116-120
23162739-3	2012	Their proline-rich motifs bind SH3 adaptor proteins such as PIX and NCK.	Proline	6-13	NCK adaptor protein 1	Homo sapiens	68-71
22181812-9	2012	A mutated HIF-1alpha protein, which has proline residues that were replaced with alanine and transfected into HEK293 cells, was not affected by the combination of LS081 and FeAC.	Proline	40-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	10-20
22226070-0	2012	Conformational preferences of proline derivatives incorporated into vasopressin analogues: NMR and molecular modelling studies.	Proline	30-37	arginine vasopressin	Homo sapiens	68-79
22354989-5	2012	We propose a model in which the initiating event for Gwl activation is phosphorylation by MPF of the proline-directed sites T193 and T206 in the presumptive activation loop.	Proline	101-108	microtubule associated serine/threonine kinase like L homeolog	Xenopus laevis	53-56
21618538-4	2012	This effect is attributed to the interaction between its proline-rich domain (PRD) and the WH1 domain of N-WASP.	Proline	57-64	WASP like actin nucleation promoting factor	Rattus norvegicus	105-111
22238231-1	2012	A proline-rich region (PRR) within the rubella virus (RUBV) P150 replicase protein that contains three SH3 domain-binding motifs (PxxPxR) was investigated for its ability to bind cell proteins.	Proline	2-9	chromatin assembly factor 1 subunit A	Homo sapiens	60-64
22462683-4	2012	Recently, we revealed a novel antioxidative mechanism in a laboratory yeast strain that is involved in stress-induced nitric oxide (NO) synthesis from proline via proline oxidase Put1 and N-acetyltransferase Mpr1.	Proline	151-158	proline dehydrogenase	Saccharomyces cerevisiae S288C	179-183
22462683-4	2012	Recently, we revealed a novel antioxidative mechanism in a laboratory yeast strain that is involved in stress-induced nitric oxide (NO) synthesis from proline via proline oxidase Put1 and N-acetyltransferase Mpr1.	Proline	151-158	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	208-212
22462683-5	2012	We also found that expression of the proline-feedback inhibition-less sensitive mutant gamma-glutamyl kinase (Pro1-I150T) and the thermostable mutant Mpr1-F65L resulted in an enhanced fermentation ability of baker"s yeast in bread dough after freeze-thaw stress and air-drying stress, respectively.	Proline	37-44	glutamate 5-kinase	Saccharomyces cerevisiae S288C	110-115
22462683-5	2012	We also found that expression of the proline-feedback inhibition-less sensitive mutant gamma-glutamyl kinase (Pro1-I150T) and the thermostable mutant Mpr1-F65L resulted in an enhanced fermentation ability of baker"s yeast in bread dough after freeze-thaw stress and air-drying stress, respectively.	Proline	37-44	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	150-154
22462683-7	2012	RESULTS: We constructed a self-cloned diploid baker"s yeast strain with enhanced proline and NO synthesis by expressing Pro1-I150T and Mpr1-F65L in the presence of functional Put1.	Proline	81-88	glutamate 5-kinase	Saccharomyces cerevisiae S288C	120-124
22462683-12	2012	CONCLUSIONS: In this work, we clarified the importance of Put1- and Mpr1-mediated NO generation from proline to the baking-associated stress tolerance in industrial baker"s yeast.	Proline	101-108	proline dehydrogenase	Saccharomyces cerevisiae S288C	58-62
22462683-12	2012	CONCLUSIONS: In this work, we clarified the importance of Put1- and Mpr1-mediated NO generation from proline to the baking-associated stress tolerance in industrial baker"s yeast.	Proline	101-108	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	68-72
22462683-13	2012	We also demonstrated that baker"s yeast that enhances the proline and NO synthetic pathway by expressing the Pro1-I150T and Mpr1-F65L variants showed improved fermentation ability under multiple baking-associated stress conditions.	Proline	58-65	glutamate 5-kinase	Saccharomyces cerevisiae S288C	109-114
22462683-13	2012	We also demonstrated that baker"s yeast that enhances the proline and NO synthetic pathway by expressing the Pro1-I150T and Mpr1-F65L variants showed improved fermentation ability under multiple baking-associated stress conditions.	Proline	58-65	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	124-128
22459723-6	2012	CABYR, which is one of these four proteins, also interacts with a diverse array of signal tranducers via its SH3-, R2D2-, and proline-rich extension-like domains.	Proline	126-133	calcium binding tyrosine phosphorylation regulated	Homo sapiens	0-5
22245250-6	2012	RESULTS: In addition to the expected changes in MMPs and collagen synthesis in HDEs in response to ATRA, prolidase, an important enzyme in the recycling of proline and hydroxyproline from degraded collagen molecules, was significantly decreased by UVA irradiation, and its down-regulation was antagonized by ATRA.	Proline	156-163	peptidase D	Homo sapiens	105-114
22403175-3	2012	Our data indicate that E2 induces the formation of a complex between androgen receptor (AR), ERbeta, and a proline-, glutamic acid-, and leucine-rich cofactor protein 1 (PELP1) in PCa cells.	Proline	107-114	androgen receptor	Homo sapiens	69-86
22403175-3	2012	Our data indicate that E2 induces the formation of a complex between androgen receptor (AR), ERbeta, and a proline-, glutamic acid-, and leucine-rich cofactor protein 1 (PELP1) in PCa cells.	Proline	107-114	androgen receptor	Homo sapiens	88-90
22403175-3	2012	Our data indicate that E2 induces the formation of a complex between androgen receptor (AR), ERbeta, and a proline-, glutamic acid-, and leucine-rich cofactor protein 1 (PELP1) in PCa cells.	Proline	107-114	proline, glutamate and leucine rich protein 1	Homo sapiens	170-175
22298770-3	2012	This slow phase appears to be due to cis to trans prolyl isomerization of the Asp(29)-Pro(30) peptide bond in wild-type AHSP because it was absent when alphaCO was mixed with P30A and P30W AHSP, which are fixed in the trans conformation.	Proline	86-89	alpha hemoglobin stabilizing protein	Homo sapiens	120-124
22326709-4	2012	Ang-(1-7) reduced (3)H-thymidine, -leucine and -proline incorporation into cardiac fibroblasts stimulated with serum or the mitogen endothelin-1 (ET-1), demonstrating that the heptapeptide hormone decreases DNA, protein and collagen synthesis.	Proline	48-55	angiogenin	Rattus norvegicus	0-3
22234618-8	2012	Co-administration of proline or tryptophan changed the pharmacokinetic profile, indicating a role of PAT1 in the rectal absorption of vigabatrin.	Proline	21-28	amyloid beta precursor protein binding protein 2	Rattus norvegicus	101-105
22334681-2	2012	Pah1p is phosphorylated on seven (Ser-110, Ser-114, Ser-168, Ser-602, Thr-723, Ser-744, and Ser-748) sites that are targets for proline-directed protein kinases.	Proline	128-135	phosphatidate phosphatase PAH1	Saccharomyces cerevisiae S288C	0-5
22464332-0	2012	Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer"s disease.	Proline	0-7	microtubule associated protein tau	Homo sapiens	63-66
22282497-4	2012	Resistance to atovaquone in the field is associated with point mutations in the Q(o) pocket of cytochrome b, most notably near the conserved Pro(260)-Glu(261)-Trp(262)-Tyr(263) (PEWY) region in the ef loop).	Proline	141-144	mitochondrially encoded cytochrome b	Homo sapiens	95-107
22356513-6	2012	Of particular interest was the Val variant commonly found in the protein elastin, which contained a 25% population of irregular beta turns containing two peptide hydrogen bonds to the proline C O.	Proline	184-191	elastin	Homo sapiens	73-80
22252129-7	2012	The observed effects of hypoxia and egl-9 mutations require the activity of the proline-directed CDK-5 kinase and the CDK-5 phosphorylation sites on LIN-10, suggesting that EGL-9 and CDK-5 compete in an oxygen-dependent manner to regulate LIN-10 activity and thus GLR-1 trafficking.	Proline	80-87	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	36-41
22252129-7	2012	The observed effects of hypoxia and egl-9 mutations require the activity of the proline-directed CDK-5 kinase and the CDK-5 phosphorylation sites on LIN-10, suggesting that EGL-9 and CDK-5 compete in an oxygen-dependent manner to regulate LIN-10 activity and thus GLR-1 trafficking.	Proline	80-87	Cyclin-dependent-like kinase 5	Caenorhabditis elegans	97-102
24213313-6	2012	We have developed strategies to strengthen the ECM collagen and inhibit MMPs through micronutrients such as lysine, proline and ascorbic acid.	Proline	116-123	matrix metallopeptidase 2	Homo sapiens	72-76
24198583-14	2012	A significant (P &lt; 0.05) elevation of IL-6 was seen immediately post-exercise and 12 hours post-exercise with both the CHO-alone and 4:1 CHO/PRO solutions.	Proline	144-147	interleukin 6	Homo sapiens	41-45
22252129-7	2012	The observed effects of hypoxia and egl-9 mutations require the activity of the proline-directed CDK-5 kinase and the CDK-5 phosphorylation sites on LIN-10, suggesting that EGL-9 and CDK-5 compete in an oxygen-dependent manner to regulate LIN-10 activity and thus GLR-1 trafficking.	Proline	80-87	Protein lin-10	Caenorhabditis elegans	149-155
22252129-7	2012	The observed effects of hypoxia and egl-9 mutations require the activity of the proline-directed CDK-5 kinase and the CDK-5 phosphorylation sites on LIN-10, suggesting that EGL-9 and CDK-5 compete in an oxygen-dependent manner to regulate LIN-10 activity and thus GLR-1 trafficking.	Proline	80-87	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	173-178
22252129-7	2012	The observed effects of hypoxia and egl-9 mutations require the activity of the proline-directed CDK-5 kinase and the CDK-5 phosphorylation sites on LIN-10, suggesting that EGL-9 and CDK-5 compete in an oxygen-dependent manner to regulate LIN-10 activity and thus GLR-1 trafficking.	Proline	80-87	Protein lin-10	Caenorhabditis elegans	239-245
22252129-7	2012	The observed effects of hypoxia and egl-9 mutations require the activity of the proline-directed CDK-5 kinase and the CDK-5 phosphorylation sites on LIN-10, suggesting that EGL-9 and CDK-5 compete in an oxygen-dependent manner to regulate LIN-10 activity and thus GLR-1 trafficking.	Proline	80-87	Glutamate receptor 1	Caenorhabditis elegans	264-269
21835190-4	2012	The aim of the present article is to reveal that the snake proline-rich oligopeptides, known as bradykinin-potentiating peptides, are still a source of surprising scientific discoveries, some of them useful not only to reveal potential new targets but also to introduce prospective lead molecules for drug development.	Proline	59-66	kininogen 1	Homo sapiens	96-106
22185821-0	2012	Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kappaB and Nrf2 signalling.	Proline	10-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	76-80
22120523-1	2012	The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region.	Proline	111-118	protein shisa-1 L homeolog	Xenopus laevis	4-9
22226915-2	2012	TMEM207 has a C-terminal proline-rich PPxY motif, which binds to the WW domain-containing oxidoreductase, WWOX.	Proline	25-32	transmembrane protein 207	Homo sapiens	0-7
22226915-2	2012	TMEM207 has a C-terminal proline-rich PPxY motif, which binds to the WW domain-containing oxidoreductase, WWOX.	Proline	25-32	WW domain containing oxidoreductase	Homo sapiens	106-110
22185821-3	2012	By knocking down the Nrf2 gene, we confirmed that cyclo(His-Pro) inhibits NF-kappaB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway.	Proline	60-63	heme oxygenase 1	Rattus norvegicus	173-189
22185821-5	2012	Cyclooxygenase-2 and matrix metalloproteinase 3, two gene products governed by NF-kappaB, were down-regulated by cyclo(His-Pro) and up-regulated in heme oxygenase-1 knock-down cells.	Proline	123-126	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	0-47
22185821-3	2012	By knocking down the Nrf2 gene, we confirmed that cyclo(His-Pro) inhibits NF-kappaB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway.	Proline	60-63	NFE2 like bZIP transcription factor 2	Rattus norvegicus	21-25
22185821-3	2012	By knocking down the Nrf2 gene, we confirmed that cyclo(His-Pro) inhibits NF-kappaB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway.	Proline	60-63	NFE2 like bZIP transcription factor 2	Rattus norvegicus	168-172
22145976-0	2012	HLA-B*08:01:08- joining the fold of silent alpha-1 proline mutations in HLA-B.	Proline	51-58	major histocompatibility complex, class I, B	Homo sapiens	0-5
22357201-2	2012	Among TP53 gene polymorphisms, the most studied is the G to C transversion in exon 4 at codon 72, which results in three distinct genotypes, Arg/Arg, Pro/Pro and Arg/Pro, each one encoding different p53 isoforms.	Proline	150-153	tumor protein p53	Homo sapiens	6-10
22357201-2	2012	Among TP53 gene polymorphisms, the most studied is the G to C transversion in exon 4 at codon 72, which results in three distinct genotypes, Arg/Arg, Pro/Pro and Arg/Pro, each one encoding different p53 isoforms.	Proline	154-157	tumor protein p53	Homo sapiens	6-10
22357201-2	2012	Among TP53 gene polymorphisms, the most studied is the G to C transversion in exon 4 at codon 72, which results in three distinct genotypes, Arg/Arg, Pro/Pro and Arg/Pro, each one encoding different p53 isoforms.	Proline	154-157	tumor protein p53	Homo sapiens	6-10
22259020-4	2012	These studies showed that aspartate-8, histidine-11, glycine-6, proline-4, arginine-1, and proline-9, arranged in an order of importance, were critical, while threonine-2, valine-3, serine-5, and the previously assigned hydroxylation and arabinosylation residue proline-7 were trivial for the endogenous CLV3 function in SAM maintenance.	Proline	64-71	CLAVATA3	Arabidopsis thaliana	304-308
22259020-4	2012	These studies showed that aspartate-8, histidine-11, glycine-6, proline-4, arginine-1, and proline-9, arranged in an order of importance, were critical, while threonine-2, valine-3, serine-5, and the previously assigned hydroxylation and arabinosylation residue proline-7 were trivial for the endogenous CLV3 function in SAM maintenance.	Proline	91-98	CLAVATA3	Arabidopsis thaliana	304-308
22259020-4	2012	These studies showed that aspartate-8, histidine-11, glycine-6, proline-4, arginine-1, and proline-9, arranged in an order of importance, were critical, while threonine-2, valine-3, serine-5, and the previously assigned hydroxylation and arabinosylation residue proline-7 were trivial for the endogenous CLV3 function in SAM maintenance.	Proline	91-98	CLAVATA3	Arabidopsis thaliana	304-308
22145976-0	2012	HLA-B*08:01:08- joining the fold of silent alpha-1 proline mutations in HLA-B.	Proline	51-58	adrenoceptor alpha 1D	Homo sapiens	43-50
22145976-0	2012	HLA-B*08:01:08- joining the fold of silent alpha-1 proline mutations in HLA-B.	Proline	51-58	major histocompatibility complex, class I, B	Homo sapiens	72-77
22235112-4	2012	In this assay, fusion proteins of Tau and Pin1 (peptidyl-prolyl cis-trans-isomerase 1) carrying complementary fragments of a luciferase protein serve as a sensor of altered protein-protein interaction between Tau and Pin1, a critical regulator of Tau dephosphorylation at several disease-associated proline-directed phosphorylation sites.	Proline	299-306	microtubule associated protein tau	Homo sapiens	34-37
22369660-3	2012	The BRCT domains of BRCA1 constitute a phospho-peptide binding domain recognizing a phospho-SPxF motif (S, serine; P, proline; x varies; F, phenylalanine).	Proline	118-125	BRCA1 DNA repair associated	Homo sapiens	20-25
22235112-4	2012	In this assay, fusion proteins of Tau and Pin1 (peptidyl-prolyl cis-trans-isomerase 1) carrying complementary fragments of a luciferase protein serve as a sensor of altered protein-protein interaction between Tau and Pin1, a critical regulator of Tau dephosphorylation at several disease-associated proline-directed phosphorylation sites.	Proline	299-306	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	42-46
22235112-4	2012	In this assay, fusion proteins of Tau and Pin1 (peptidyl-prolyl cis-trans-isomerase 1) carrying complementary fragments of a luciferase protein serve as a sensor of altered protein-protein interaction between Tau and Pin1, a critical regulator of Tau dephosphorylation at several disease-associated proline-directed phosphorylation sites.	Proline	299-306	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	48-85
22235112-4	2012	In this assay, fusion proteins of Tau and Pin1 (peptidyl-prolyl cis-trans-isomerase 1) carrying complementary fragments of a luciferase protein serve as a sensor of altered protein-protein interaction between Tau and Pin1, a critical regulator of Tau dephosphorylation at several disease-associated proline-directed phosphorylation sites.	Proline	299-306	microtubule associated protein tau	Homo sapiens	209-212
22235112-4	2012	In this assay, fusion proteins of Tau and Pin1 (peptidyl-prolyl cis-trans-isomerase 1) carrying complementary fragments of a luciferase protein serve as a sensor of altered protein-protein interaction between Tau and Pin1, a critical regulator of Tau dephosphorylation at several disease-associated proline-directed phosphorylation sites.	Proline	299-306	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	217-221
22235112-4	2012	In this assay, fusion proteins of Tau and Pin1 (peptidyl-prolyl cis-trans-isomerase 1) carrying complementary fragments of a luciferase protein serve as a sensor of altered protein-protein interaction between Tau and Pin1, a critical regulator of Tau dephosphorylation at several disease-associated proline-directed phosphorylation sites.	Proline	299-306	microtubule associated protein tau	Homo sapiens	209-212
22334067-2	2012	To prepare the starting materials N-Boc-sulfamide derivatives of sarcosine or proline were alkylated with benzyl alcohol under Mitsunobu reaction conditions, the Boc group was removed chemoselectively by acidolysis, and the resulting product reduced to the corresponding alcohol in good yields.	Proline	78-85	BOC cell adhesion associated, oncogene regulated	Homo sapiens	36-39
22248857-1	2012	Efforts to modify the central proline portion of lead compound 4 lead to the discovery of novel prolylcarboxypeptidase (PrCP) inhibitors.	Proline	30-37	prolylcarboxypeptidase	Homo sapiens	96-118
22248857-1	2012	Efforts to modify the central proline portion of lead compound 4 lead to the discovery of novel prolylcarboxypeptidase (PrCP) inhibitors.	Proline	30-37	prolylcarboxypeptidase	Homo sapiens	120-124
22101193-1	2012	Prolyl oligopeptidase (PREP, E.C.3.4.21.26) is a cytosolic serine protease that hydrolyzes small (&lt;3 kDa), proline-containing peptides on the carboxyl terminal side of proline residues, and is widely distributed in the brain.	Proline	110-117	prolyl endopeptidase	Rattus norvegicus	0-21
22101193-1	2012	Prolyl oligopeptidase (PREP, E.C.3.4.21.26) is a cytosolic serine protease that hydrolyzes small (&lt;3 kDa), proline-containing peptides on the carboxyl terminal side of proline residues, and is widely distributed in the brain.	Proline	110-117	prolyl endopeptidase	Rattus norvegicus	23-27
22101193-1	2012	Prolyl oligopeptidase (PREP, E.C.3.4.21.26) is a cytosolic serine protease that hydrolyzes small (&lt;3 kDa), proline-containing peptides on the carboxyl terminal side of proline residues, and is widely distributed in the brain.	Proline	171-178	prolyl endopeptidase	Rattus norvegicus	0-21
22101193-1	2012	Prolyl oligopeptidase (PREP, E.C.3.4.21.26) is a cytosolic serine protease that hydrolyzes small (&lt;3 kDa), proline-containing peptides on the carboxyl terminal side of proline residues, and is widely distributed in the brain.	Proline	171-178	prolyl endopeptidase	Rattus norvegicus	23-27
22264476-2	2012	While most previously described Smac mimetics contain the proline ring (or a similar cyclic motif) found in Smac, a key feature of the compounds described herein is that this ring has been removed.	Proline	58-65	diablo IAP-binding mitochondrial protein	Homo sapiens	32-36
22264476-2	2012	While most previously described Smac mimetics contain the proline ring (or a similar cyclic motif) found in Smac, a key feature of the compounds described herein is that this ring has been removed.	Proline	58-65	diablo IAP-binding mitochondrial protein	Homo sapiens	108-112
22334067-2	2012	To prepare the starting materials N-Boc-sulfamide derivatives of sarcosine or proline were alkylated with benzyl alcohol under Mitsunobu reaction conditions, the Boc group was removed chemoselectively by acidolysis, and the resulting product reduced to the corresponding alcohol in good yields.	Proline	78-85	BOC cell adhesion associated, oncogene regulated	Homo sapiens	162-165
22327401-4	2012	Here we show that HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity; this inhibition is reversed by the addition of exogenous proline or EPRS.	Proline	168-175	glutamyl-prolyl-tRNA synthetase	Mus musculus	27-58
22327401-4	2012	Here we show that HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity; this inhibition is reversed by the addition of exogenous proline or EPRS.	Proline	168-175	glutamyl-prolyl-tRNA synthetase	Mus musculus	60-64
21725361-7	2012	Intriguingly, p140Cap associates with cortactin via interaction with its second proline-rich domain to the cortactin SH3 domain.	Proline	80-87	SRC kinase signaling inhibitor 1	Rattus norvegicus	14-21
22178478-8	2012	In the other class, nucleation is actively suppressed by a proline-rich polyQ segment covalently attached to htt(NT).	Proline	59-66	huntingtin	Homo sapiens	109-112
22155079-0	2012	Effects of pathogenic proline mutations on myosin assembly.	Proline	22-29	myosin heavy chain 14	Homo sapiens	43-49
21725361-7	2012	Intriguingly, p140Cap associates with cortactin via interaction with its second proline-rich domain to the cortactin SH3 domain.	Proline	80-87	cortactin	Rattus norvegicus	38-47
22297986-7	2012	Thus, for Itk SH2 structural analysis by NMR spectroscopy and X-ray crystallography revealed very different structural features: proline isomerization versus domain-swapped dimerization, respectively.	Proline	129-136	IL2 inducible T cell kinase	Homo sapiens	10-13
22014333-10	2012	VASP Y39D had a reduced affinity to the proline-rich region of zyxin.	Proline	40-47	enabled	Drosophila melanogaster	0-4
22360890-6	2012	NF-L exposure to salsolinol produced losses of glutamate, lysine and proline residues.	Proline	69-76	neurofilament light chain	Homo sapiens	0-4
22140244-8	2012	There were indications of adjustments in extra-chloroplastic components of photorespiration and proline levels, which all could dissipate excess reducing equivalents, sustain photosynthesis, and prevent photoinhibition in nadp-mdh knockout plants.	Proline	96-103	lactate/malate dehydrogenase family protein	Arabidopsis thaliana	222-230
21993963-2	2012	3.4.13.9] activity, proline or hydroxyproline, contribute to up-regulation of hypoxia-inducible factor-1alpha (HIF-1alpha).	Proline	20-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-109
21607615-2	2012	A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein.	Proline	155-162	tumor protein p53	Homo sapiens	115-118
21993963-2	2012	3.4.13.9] activity, proline or hydroxyproline, contribute to up-regulation of hypoxia-inducible factor-1alpha (HIF-1alpha).	Proline	20-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-121
21607615-2	2012	A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein.	Proline	155-162	tumor protein p53	Homo sapiens	239-242
21607615-2	2012	A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein.	Proline	164-167	tumor protein p53	Homo sapiens	115-118
22307851-5	2012	Mutant plants were also highly sensitive to long days and accumulated, like TOR RNA interference lines, higher amounts of starch and amino acids, including proline and glutamine, while showing reduced concentrations of inositol and raffinose.	Proline	156-163	target of rapamycin	Arabidopsis thaliana	76-79
21607615-2	2012	A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein.	Proline	164-167	tumor protein p53	Homo sapiens	239-242
21607615-2	2012	A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein.	Proline	216-223	tumor protein p53	Homo sapiens	115-118
21607615-2	2012	A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein.	Proline	216-223	tumor protein p53	Homo sapiens	239-242
22266216-6	2012	It seems that while NPY or [Leu(31), Pro(34)]-NPY potentiated, BIBP3226 attenuated the learning and memory enhancing effects of nicotine.	Proline	37-40	neuropeptide Y	Rattus norvegicus	46-49
22186181-5	2012	Compared with the wild type, the 35S::nNOS plants displayed improved salt and drought tolerance, which was further confirmed by changes in physiological parameters including reduced water loss rate, reduced stomatal aperture, and altered proline and malondialdehyde content.	Proline	238-245	nitric oxide synthase 1	Rattus norvegicus	38-42
22089129-7	2012	In the present study we identified a G to C nucleotide exchange in exon 15 of the Atp7a gene in mosaic mutants, which resulted in an arginine to proline substitution in the highly conserved 6th transmembrane domain of the ATP7A protein.	Proline	145-152	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	82-87
22089129-7	2012	In the present study we identified a G to C nucleotide exchange in exon 15 of the Atp7a gene in mosaic mutants, which resulted in an arginine to proline substitution in the highly conserved 6th transmembrane domain of the ATP7A protein.	Proline	145-152	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	222-227
22345491-7	2012	Metabolite profiling identified elevated Pro and trehalose levels in JUB1 overexpressors, in accordance with their enhanced abiotic stress tolerance.	Proline	41-44	NAC domain containing protein 42	Arabidopsis thaliana	69-73
22286099-2	2012	In high O(2) tension (normoxia) the PHDs hydroxylate two conserved proline residues on HIF-1alpha, which leads to binding of the von Hippel-Lindau (VHL) tumour suppressor, the recognition component of a ubiquitin-ligase complex, initiating HIF-1alpha ubiquitylation and degradation.	Proline	67-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-97
22072628-4	2012	TauF4 was phosphorylated by the proline-directed CDK2/CycA3 kinase on Thr231 (generating the AT180 epitope), Ser235, and equally on Thr212 and Thr217 in the Proline-rich region (Tau[Ser208-Gln244] or PRR).	Proline	32-39	cyclin dependent kinase 2	Homo sapiens	49-53
22105828-1	2012	Transportin 1 (Trn1), as a typical transport receptor of the karyopherin-beta family, mediates numerous RNA binding proteins into the nucleus by recognizing proline-tyrosine nuclear localization signals (PY-NLSs).	Proline	157-164	transportin 1	Homo sapiens	0-13
22105828-1	2012	Transportin 1 (Trn1), as a typical transport receptor of the karyopherin-beta family, mediates numerous RNA binding proteins into the nucleus by recognizing proline-tyrosine nuclear localization signals (PY-NLSs).	Proline	157-164	transportin 1	Homo sapiens	15-19
22286099-2	2012	In high O(2) tension (normoxia) the PHDs hydroxylate two conserved proline residues on HIF-1alpha, which leads to binding of the von Hippel-Lindau (VHL) tumour suppressor, the recognition component of a ubiquitin-ligase complex, initiating HIF-1alpha ubiquitylation and degradation.	Proline	67-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	240-250
22832103-4	2012	PRRT2 encodes a proline-rich transmembrane protein of unknown function that has been reported to interact with the t-SNARE, SNAP25.	Proline	16-23	proline rich transmembrane protein 2	Homo sapiens	0-5
22284676-7	2012	We also identify Ssu72 as the Ser7 phosphatase and show that proline isomerization is a key regulator of CTD dephosphorylation at the end of genes.	Proline	61-68	SSU72 homolog, RNA polymerase II CTD phosphatase	Homo sapiens	17-22
22832103-4	2012	PRRT2 encodes a proline-rich transmembrane protein of unknown function that has been reported to interact with the t-SNARE, SNAP25.	Proline	16-23	small NF90 (ILF3) associated RNA E	Homo sapiens	117-122
22832103-4	2012	PRRT2 encodes a proline-rich transmembrane protein of unknown function that has been reported to interact with the t-SNARE, SNAP25.	Proline	16-23	synaptosome associated protein 25	Homo sapiens	124-130
22105071-11	2012	Mutations of residues Cys-947, Pro-948, and Phe-949 at the C terminus of this region completely disrupted MOV10 anti-HIV-1 activity.	Proline	31-34	Mov10 RISC complex RNA helicase	Homo sapiens	106-111
22117044-4	2012	In the current study, we show that these thymic lymphomas also commonly exhibit activating Notch1 mutations in the proline-glutamic acid-serine-threonine (PEST) domain.	Proline	115-122	notch 1	Mus musculus	91-97
22091817-1	2012	The biocatalytic versatility of wildtype and engineered carboxymethylproline synthases (CMPSs) is demonstrated by the preparation of functionalized 5-carboxymethylproline derivatives methylated at C-2, C-3, C-4, or C-5 of the proline ring from appropriately substituted amino acid aldehydes and malonyl-coenzyme A.	Proline	69-76	complement C2	Homo sapiens	197-205
22091817-1	2012	The biocatalytic versatility of wildtype and engineered carboxymethylproline synthases (CMPSs) is demonstrated by the preparation of functionalized 5-carboxymethylproline derivatives methylated at C-2, C-3, C-4, or C-5 of the proline ring from appropriately substituted amino acid aldehydes and malonyl-coenzyme A.	Proline	69-76	complement C4A (Rodgers blood group)	Homo sapiens	207-210
22091817-1	2012	The biocatalytic versatility of wildtype and engineered carboxymethylproline synthases (CMPSs) is demonstrated by the preparation of functionalized 5-carboxymethylproline derivatives methylated at C-2, C-3, C-4, or C-5 of the proline ring from appropriately substituted amino acid aldehydes and malonyl-coenzyme A.	Proline	69-76	complement C5	Homo sapiens	215-218
22146521-0	2012	The proline TP53 variant stimulates likely lymphangiogenesis in an orthotopic mouse model of pancreatic cancer.	Proline	4-11	transformation related protein 53	Mus musculus	12-16
22148750-8	2012	Serine 38 represents a putative proline-directed kinase target site located on a solvent-exposed loop that is positioned at one end of the Sod1p beta-barrel, a region immediately adjacent to residues previously shown to influence CCS-dependent activation.	Proline	32-39	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	139-144
22289634-1	2012	Human TP53 gene is characterised by a polymorphism at codon 72 leading to an Arginine-to-Proline (R/P) substitution.	Proline	89-96	tumor protein p53	Homo sapiens	6-10
21801810-7	2012	The insulin induced translocation of GLUT4 was attenuated by the Y1 receptor agonist [Phe(7),Pro(34)] pNPY, demonstrating an essential role of the Y1 receptor in GLUT4 translocation.	Proline	93-96	insulin	Homo sapiens	4-11
21801810-7	2012	The insulin induced translocation of GLUT4 was attenuated by the Y1 receptor agonist [Phe(7),Pro(34)] pNPY, demonstrating an essential role of the Y1 receptor in GLUT4 translocation.	Proline	93-96	solute carrier family 2 member 4	Homo sapiens	37-42
21801810-7	2012	The insulin induced translocation of GLUT4 was attenuated by the Y1 receptor agonist [Phe(7),Pro(34)] pNPY, demonstrating an essential role of the Y1 receptor in GLUT4 translocation.	Proline	93-96	solute carrier family 2 member 4	Homo sapiens	162-167
21535414-7	2012	Dishevelled-3 displays some regions, where the proline content is &gt;40%.	Proline	47-54	dishevelled	Drosophila melanogaster	0-11
22631671-0	2012	Pro variant of TP53 Arg72Pro contributes to gastric cancer risk in Asians: evidence from a meta-analysis.	Proline	0-3	tumor protein p53	Homo sapiens	15-19
22089387-1	2012	Dye-linked L-proline dehydrogenase (ProDH) catalyzes the oxidation of L-proline to  (1)-pyrroline-5-carboxylate (P5C) in the presence of artificial electron acceptors.	Proline	11-20	proline dehydrogenase 1	Homo sapiens	36-41
22089387-2	2012	The enzyme is known to be widely distributed in bacteria and eukarya, together with nicotinamide adenine dinucleotide (phosphate)-dependent P5C dehydrogenase, and to function in the metabolism of L-proline to L-glutamate.	Proline	196-205	aldehyde dehydrogenase 4 family member A1	Homo sapiens	140-157
22502699-2	2012	A common single nucleotide polymorphism located within the proline rich region of TP53 gene at codon 72 in exon 4 encodes either proline or arginine.	Proline	59-66	tumor protein p53	Homo sapiens	82-86
22502699-2	2012	A common single nucleotide polymorphism located within the proline rich region of TP53 gene at codon 72 in exon 4 encodes either proline or arginine.	Proline	129-136	tumor protein p53	Homo sapiens	82-86
22502699-3	2012	TP53 Arg 72 is more active than TP53 Pro 72 in inducing apoptosis.	Proline	37-40	tumor protein p53	Homo sapiens	0-4
22901126-2	2012	Ser/Cys polymorphism in hOGG1 and Arg/Pro polymorphism in p53 among 124 patients with lung cancer and 128 normal people were detected using PCR-RFLP.	Proline	38-41	tumor protein p53	Homo sapiens	58-61
21958667-0	2012	Caveolin-1 hydrophobic segment peptides insertion into membrane mimetic systems: role of proline residue.	Proline	89-96	caveolin 1	Homo sapiens	0-10
22005517-7	2012	The deletion of P0, P1 and P2 proline rich domains in N-terminus as well as P4 and P5 in C-terminus of Sam68 increased BRET(50), thus indicating that the affinity of Sam68 for IRS1 is lower when these domains are missing.	Proline	30-37	crystallin gamma F, pseudogene	Homo sapiens	16-29
22005517-7	2012	The deletion of P0, P1 and P2 proline rich domains in N-terminus as well as P4 and P5 in C-terminus of Sam68 increased BRET(50), thus indicating that the affinity of Sam68 for IRS1 is lower when these domains are missing.	Proline	30-37	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	103-108
21792844-1	2012	An 18-residue sequence Boc-Aib-Val-Ala-Leu-Aib-Val-Ala-Leu-Gly-Pro-Val-Ala-Leu-Aib-Val-Ala-Leu-Aib-OMe (UK18) was designed to examine the effect of introducing a Gly-Pro segment into the middle of a potentially helical peptide.	Proline	63-66	ANIB1	Homo sapiens	27-30
22005517-7	2012	The deletion of P0, P1 and P2 proline rich domains in N-terminus as well as P4 and P5 in C-terminus of Sam68 increased BRET(50), thus indicating that the affinity of Sam68 for IRS1 is lower when these domains are missing.	Proline	30-37	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	166-171
22005517-7	2012	The deletion of P0, P1 and P2 proline rich domains in N-terminus as well as P4 and P5 in C-terminus of Sam68 increased BRET(50), thus indicating that the affinity of Sam68 for IRS1 is lower when these domains are missing.	Proline	30-37	insulin receptor substrate 1	Homo sapiens	176-180
23144545-4	2012	The presence of MYBAS1 consensus binding sites occurring in combination with O2 and OCSBF1 in the promoters of genes of proline biosynthesis pathway and SBF1 and GT1 consensus binding sites occurring in combination with O2 and OCSBF1 in the promoters of proline catabolic pathway genes suggest their involvement in modulation of proline metabolism and its accumulation in plants.	Proline	120-127	MYB antisense RNA 1	Homo sapiens	16-22
23144545-4	2012	The presence of MYBAS1 consensus binding sites occurring in combination with O2 and OCSBF1 in the promoters of genes of proline biosynthesis pathway and SBF1 and GT1 consensus binding sites occurring in combination with O2 and OCSBF1 in the promoters of proline catabolic pathway genes suggest their involvement in modulation of proline metabolism and its accumulation in plants.	Proline	120-127	SET binding factor 1	Homo sapiens	86-90
21792844-1	2012	An 18-residue sequence Boc-Aib-Val-Ala-Leu-Aib-Val-Ala-Leu-Gly-Pro-Val-Ala-Leu-Aib-Val-Ala-Leu-Aib-OMe (UK18) was designed to examine the effect of introducing a Gly-Pro segment into the middle of a potentially helical peptide.	Proline	63-66	ANIB1	Homo sapiens	43-46
21792844-1	2012	An 18-residue sequence Boc-Aib-Val-Ala-Leu-Aib-Val-Ala-Leu-Gly-Pro-Val-Ala-Leu-Aib-Val-Ala-Leu-Aib-OMe (UK18) was designed to examine the effect of introducing a Gly-Pro segment into the middle of a potentially helical peptide.	Proline	63-66	ANIB1	Homo sapiens	43-46
21792844-1	2012	An 18-residue sequence Boc-Aib-Val-Ala-Leu-Aib-Val-Ala-Leu-Gly-Pro-Val-Ala-Leu-Aib-Val-Ala-Leu-Aib-OMe (UK18) was designed to examine the effect of introducing a Gly-Pro segment into the middle of a potentially helical peptide.	Proline	63-66	ANIB1	Homo sapiens	43-46
21906675-0	2012	Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway.	Proline	0-7	AKT serine/threonine kinase 1	Homo sapiens	13-16
23144545-4	2012	The presence of MYBAS1 consensus binding sites occurring in combination with O2 and OCSBF1 in the promoters of genes of proline biosynthesis pathway and SBF1 and GT1 consensus binding sites occurring in combination with O2 and OCSBF1 in the promoters of proline catabolic pathway genes suggest their involvement in modulation of proline metabolism and its accumulation in plants.	Proline	120-127	beta-1,4-galactosyltransferase 1	Homo sapiens	162-165
28066692-4	2012	A proline-directed serine/threonine (S/T) kinase, predominantly active in the nervous system, Cdk5 regulates a multitude of functions including nervous system development, neuronal migration, cytoskeletal dynamics, axonal guidance, synaptic plasticity, neurotransmission, neuronal survival and death, to mention a few.	Proline	2-9	cyclin dependent kinase 5	Homo sapiens	94-98
21660049-9	2012	These results provide novel insights that, following stress-induced phosphorylation of Thr in the Thr-Pro motif of JNK1, JNK1 associates with Pin1 and undergoes conformational changes to promote the binding of JNK1 to its substrates, resulting in cellular responses from extracellular signals.	Proline	102-105	mitogen-activated protein kinase 8	Homo sapiens	115-119
21660049-9	2012	These results provide novel insights that, following stress-induced phosphorylation of Thr in the Thr-Pro motif of JNK1, JNK1 associates with Pin1 and undergoes conformational changes to promote the binding of JNK1 to its substrates, resulting in cellular responses from extracellular signals.	Proline	102-105	mitogen-activated protein kinase 8	Homo sapiens	121-125
21660049-9	2012	These results provide novel insights that, following stress-induced phosphorylation of Thr in the Thr-Pro motif of JNK1, JNK1 associates with Pin1 and undergoes conformational changes to promote the binding of JNK1 to its substrates, resulting in cellular responses from extracellular signals.	Proline	102-105	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	142-146
21660049-9	2012	These results provide novel insights that, following stress-induced phosphorylation of Thr in the Thr-Pro motif of JNK1, JNK1 associates with Pin1 and undergoes conformational changes to promote the binding of JNK1 to its substrates, resulting in cellular responses from extracellular signals.	Proline	102-105	mitogen-activated protein kinase 8	Homo sapiens	121-125
21615728-4	2012	These include a triple proline deletion in HCN2 that increases channel function and occurs more often in patients with febrile seizure syndromes.	Proline	23-30	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	43-47
21906675-0	2012	Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway.	Proline	0-7	AKT1 substrate 1	Homo sapiens	37-43
21906675-0	2012	Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway.	Proline	0-7	AKT serine/threonine kinase 1	Homo sapiens	80-83
21924349-1	2012	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is mostly active in the nervous system, where it regulates several processes such as neuronal migration, actin and microtubule dynamics, axonal guidance, and synaptic plasticity, among other processes.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
21924349-1	2012	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is mostly active in the nervous system, where it regulates several processes such as neuronal migration, actin and microtubule dynamics, axonal guidance, and synaptic plasticity, among other processes.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
22032839-5	2012	CsA suppresses organ rejection by halting productions of pro-inflammatory molecules in T cell and abolishes the enzymatic property of CypB that accelerates the folding of proteins by catalysing the isomerization of peptidyl-proline bonds in ER.	Proline	224-231	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	0-3
22664251-2	2012	We synthesized and evaluated a library of proline-based analogs as prospective recombinant PRCP (rPRCP) inhibitors and inhibitors of PRCP-dependent prekallikrein (PK) activation on human pulmonary artery endothelial cells (HPAEC).	Proline	42-49	prolylcarboxypeptidase	Homo sapiens	91-95
22664251-2	2012	We synthesized and evaluated a library of proline-based analogs as prospective recombinant PRCP (rPRCP) inhibitors and inhibitors of PRCP-dependent prekallikrein (PK) activation on human pulmonary artery endothelial cells (HPAEC).	Proline	42-49	prolylcarboxypeptidase	Homo sapiens	98-102
22201749-4	2012	Recent structural and kinetic evidence indicate substrate channeling of P5C/GSA occurs in the proline catabolic pathway between the proline dehydrogenase and P5C dehydrogenase active sites of bifunctional proline utilization A (PutA).	Proline	94-101	pyrroline-5-carboxylate reductase 1	Homo sapiens	72-79
22201749-4	2012	Recent structural and kinetic evidence indicate substrate channeling of P5C/GSA occurs in the proline catabolic pathway between the proline dehydrogenase and P5C dehydrogenase active sites of bifunctional proline utilization A (PutA).	Proline	94-101	aldehyde dehydrogenase 4 family member A1	Homo sapiens	158-175
22201749-4	2012	Recent structural and kinetic evidence indicate substrate channeling of P5C/GSA occurs in the proline catabolic pathway between the proline dehydrogenase and P5C dehydrogenase active sites of bifunctional proline utilization A (PutA).	Proline	132-139	pyrroline-5-carboxylate reductase 1	Homo sapiens	72-79
22201749-8	2012	Because of the unfavorable equilibrium of P5C/GSA and the reactivity of gamma-glutamyl phosphate, substrate channeling likely improves the efficiency of proline metabolism.	Proline	153-160	pyrroline-5-carboxylate reductase 1	Homo sapiens	42-49
22201764-3	2012	ProDH is not only essential for proline catabolism but also plays key roles in providing energy, shuttling redox potential between cellular compartments and reactive oxygen species production.	Proline	32-39	proline dehydrogenase 1	Homo sapiens	0-5
23094635-2	2012	Hb Agrinio [alpha29(B10)Leu Pro, CTG&gt;CCG (alpha2)] is a hyperunstable alpha chain structural variant in which the thalassemic phenotype is determined by a post translational precipitation of the structurally anomalous chain in erythroid precursors.	Proline	28-31	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	20-23
22210716-9	2012	Our study indicated that a high prevalence of the genotype Arg/Pro at the p53 codon 72 may contribute to susceptibility to OSCC, especially in combination with the use of carcinogenic tobacco-specific nitrosamine (TSNA)-rich toombak.	Proline	63-66	tumor protein p53	Homo sapiens	74-77
22071254-2	2012	The proline-substituted compound inhibited PGE(2) secretion by LPS-stimulated neutrophils, suggesting selectivity for COX-2.	Proline	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
22032839-5	2012	CsA suppresses organ rejection by halting productions of pro-inflammatory molecules in T cell and abolishes the enzymatic property of CypB that accelerates the folding of proteins by catalysing the isomerization of peptidyl-proline bonds in ER.	Proline	224-231	peptidylprolyl isomerase B	Mus musculus	134-138
22942686-3	2012	We summarize here the recent advances carried out concerning the quaternary structure of GS, as well as the functional relationship existing between GS2 and processes such as nodulation, photorespiration and water stress, in this latter case by means of proline production.	Proline	254-261	patatin like phospholipase domain containing 4	Homo sapiens	149-152
21882227-5	2012	The activities of the antioxidant enzymes catalase and superoxide dismutase were significantly increased after chronic proline administration, while glutathione (GSH) peroxidase activity, dichlorofluorescin oxidation, GSH, sulfhydryl, and carbonyl content remained unaltered.	Proline	119-126	catalase	Rattus norvegicus	42-50
21937675-5	2012	Molecular dissection studies revealed that the actin-binding site on MAP4 is situated at the C-terminal part of the proline-rich region, where the microtubule-binding site is also located.	Proline	116-123	microtubule associated protein 4	Homo sapiens	69-73
21937675-7	2012	A multiple sequence alignment of the proline-rich regions of MAP4 and tau revealed two putative actin-binding consensus sequences.	Proline	37-44	microtubule associated protein 4	Homo sapiens	61-65
22613405-1	2012	OBJECTIVE: The association between codon 72 polymorphism of the tumour protein p53 (TP53) gene - which results in a missense mutation of arginine (R) to proline (P) - and susceptibility to hepatocellular carcinoma (HCC) is controversial.	Proline	153-160	tumor protein p53	Homo sapiens	79-82
22956985-0	2012	Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice.	Proline	27-34	huntingtin	Mus musculus	16-26
22613405-1	2012	OBJECTIVE: The association between codon 72 polymorphism of the tumour protein p53 (TP53) gene - which results in a missense mutation of arginine (R) to proline (P) - and susceptibility to hepatocellular carcinoma (HCC) is controversial.	Proline	153-160	tumor protein p53	Homo sapiens	84-88
21853252-8	2012	Analyses of the abscisic acid mutants, aba1-1 and abi1-1, indicate that carnitine and proline may act through a modulation of the ABA pathway.	Proline	86-93	zeaxanthin epoxidase (ZEP) (ABA1)	Arabidopsis thaliana	39-45
21887699-0	2012	Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes.	Proline	0-7	Fyn proto-oncogene	Mus musculus	139-142
21887699-2	2012	The classic 18.5-kDa MBP isoform has a proline-rich region comprising amino acids 92-99 (murine sequence -T(92)PRTPPPS(99)-) that contains a minimal SH3 ligand domain.	Proline	39-46	myelin basic protein	Mus musculus	21-24
22895772-4	2012	Creeping bentgrass (Agrostis stolonifera L.) plants overexpressing an Arabidopsis vacuolar H(+)-pyrophosphatase AVP1 exhibited improved growth and enhanced salt tolerance, likely associated with increased photosynthesis, relative water content, proline production, and Na(+) uptake.	Proline	245-252	Inorganic H pyrophosphatase family protein	Arabidopsis thaliana	112-116
22675626-4	2012	Indeed, a group of SH3-containing accessory proteins, or adaptor proteins, have been identified that bind to a proline-rich domain of the C-terminal portion of Abl and modulate its kinase activity, substrate recognition, and intracellular localization.	Proline	111-118	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	160-163
23430876-2	2012	Prolidase is a ubiquitous enzyme that hydrolyses dipeptides with C-terminal proline or hydroxyproline residues and indeed, lack of this enzyme activity causes massive urine excretion of undigested iminodipeptides.	Proline	76-83	peptidase D	Homo sapiens	0-9
22976031-5	2012	Specifically, quantification of the strong proline-induced distortions in the transmembrane bundle of rhodopsin shows that they are not standard proline kinks.	Proline	43-50	rhodopsin	Homo sapiens	102-111
22064478-8	2012	These results establish phosphorylation-coupled proline isomerization as a mechanism modulating AF1 functional activity and provide insight into the role of a conformational switch in the functional regulation of the intrinsically disordered transactivation domain of ERalpha.	Proline	48-55	estrogen receptor 1	Rattus norvegicus	268-275
22366005-1	2012	OBJECTIVE: To obtain a specific antagonist of CXCR4, SDF-1P2G54 by mutating SDF-1 second proline (P) into glycin (G) and removing the alpha-helix of its C-terminal.	Proline	89-96	C-X-C motif chemokine receptor 4	Homo sapiens	46-51
22366005-1	2012	OBJECTIVE: To obtain a specific antagonist of CXCR4, SDF-1P2G54 by mutating SDF-1 second proline (P) into glycin (G) and removing the alpha-helix of its C-terminal.	Proline	89-96	C-X-C motif chemokine ligand 12	Homo sapiens	53-58
21880076-3	2012	In the present report, we found characteristic histidine-asparagine repeat and proline-rich regions in IDEF1 and its homolog in Hordeum vulgare (barley), HvIDEF1.	Proline	79-86	HvIDEF1	Hordeum vulgare	103-108
21880076-3	2012	In the present report, we found characteristic histidine-asparagine repeat and proline-rich regions in IDEF1 and its homolog in Hordeum vulgare (barley), HvIDEF1.	Proline	79-86	HvIDEF1	Hordeum vulgare	154-161
21853252-8	2012	Analyses of the abscisic acid mutants, aba1-1 and abi1-1, indicate that carnitine and proline may act through a modulation of the ABA pathway.	Proline	86-93	Protein phosphatase 2C family protein	Arabidopsis thaliana	50-56
21880076-6	2012	This metal-binding activity of IDEF1 was almost abolished by deletion of the histidine-asparagine and proline-rich regions, but DNA-binding and trans-activation functions were not impaired by the deletion.	Proline	102-109	HvIDEF1	Hordeum vulgare	31-36
21880076-9	2012	These results suggest that the histidine-asparagine and proline-rich regions in rice IDEF1 directly bind to divalent metals and sense the cellular metal ion balance caused by changes in iron availability.	Proline	56-63	HvIDEF1	Hordeum vulgare	85-90
22118615-2	2012	Responses to heat stress were compared in the upper and lower leaves and roots of tobacco plants that constitutively over-express a modified gene for the proline biosynthetic enzyme Delta1-pyrroline-5-carboxylate synthetase (P5CSF129A) and in the corresponding wild-type.	Proline	154-161	delta-1-pyrroline-5-carboxylate synthase-like	Nicotiana tabacum	188-223
22118619-6	2012	Proline accumulation was enhanced in the ppr40-1 mutant, but unaltered in the PPR40 overexpressing plants.	Proline	0-7	pentatricopeptide (PPR) domain protein 40	Arabidopsis thaliana	41-46
23071779-5	2012	Evidence indicates that Skp2 targets beta-TrCP for degradation via the cyclin-dependent kinase 2-facilitated recognition of the proline-directed phosphorylation motif (412)SP.	Proline	128-135	S-phase kinase associated protein 2	Homo sapiens	24-28
23071779-5	2012	Evidence indicates that Skp2 targets beta-TrCP for degradation via the cyclin-dependent kinase 2-facilitated recognition of the proline-directed phosphorylation motif (412)SP.	Proline	128-135	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	37-46
23071779-5	2012	Evidence indicates that Skp2 targets beta-TrCP for degradation via the cyclin-dependent kinase 2-facilitated recognition of the proline-directed phosphorylation motif (412)SP.	Proline	128-135	cyclin dependent kinase 2	Homo sapiens	71-96
23071787-6	2012	The frequency of somatic TP53 inactivation was 25.4% in Arg/Arg, 20.9% in Arg/Pro, and 16.7% in Pro/Pro patients, which may reflect a higher selective pressure to mutate the Arg-allele.	Proline	78-81	tumor protein p53	Homo sapiens	25-29
23071787-6	2012	The frequency of somatic TP53 inactivation was 25.4% in Arg/Arg, 20.9% in Arg/Pro, and 16.7% in Pro/Pro patients, which may reflect a higher selective pressure to mutate the Arg-allele.	Proline	96-99	tumor protein p53	Homo sapiens	25-29
23071787-6	2012	The frequency of somatic TP53 inactivation was 25.4% in Arg/Arg, 20.9% in Arg/Pro, and 16.7% in Pro/Pro patients, which may reflect a higher selective pressure to mutate the Arg-allele.	Proline	96-99	tumor protein p53	Homo sapiens	25-29
23056582-1	2012	The antiapoptotic Bcl-2 family member Mcl-1 is a PEST protein (containing sequences enriched in proline, glutamic acid, serine, and threonine) and is subject to rapid degradation via multiple pathways.	Proline	96-103	apoptosis regulator Bcl-2	Cricetulus griseus	18-23
23049825-3	2012	In this study we evaluate the association between a p53 variant functionally known to influence apoptosis (codon 72 Pro/Arg) and the subset of primary open angle glaucoma (POAG) patients with early loss of central visual field.	Proline	116-119	tumor protein p53	Homo sapiens	52-55
23236520-5	2012	Here we show that the autoinhibitory, intramolecular interactions in pacsin-1 can be released upon binding to the entire proline-rich domain (PRD) of dynamin-1, resulting in potent membrane deformation activity that is distinct from the isolated F-BAR domain.	Proline	121-128	protein kinase C and casein kinase substrate in neurons 1	Homo sapiens	69-77
23236520-5	2012	Here we show that the autoinhibitory, intramolecular interactions in pacsin-1 can be released upon binding to the entire proline-rich domain (PRD) of dynamin-1, resulting in potent membrane deformation activity that is distinct from the isolated F-BAR domain.	Proline	121-128	dynamin 1	Homo sapiens	150-159
23056582-1	2012	The antiapoptotic Bcl-2 family member Mcl-1 is a PEST protein (containing sequences enriched in proline, glutamic acid, serine, and threonine) and is subject to rapid degradation via multiple pathways.	Proline	96-103	induced myeloid leukemia cell differentiation protein Mcl-1	Cricetulus griseus	38-43
22952866-6	2012	PRINCIPAL FINDINGS: Using FAK-null fibroblasts stably reconstituted with green fluorescent protein (GFP) tagged FAK constructs, we find that FAK activity and FAK C-terminal proline-rich region 2 (PRR2) and PRR3 are required for FA turnover and cell motility.	Proline	173-180	protein tyrosine kinase 2	Homo sapiens	26-29
22952866-6	2012	PRINCIPAL FINDINGS: Using FAK-null fibroblasts stably reconstituted with green fluorescent protein (GFP) tagged FAK constructs, we find that FAK activity and FAK C-terminal proline-rich region 2 (PRR2) and PRR3 are required for FA turnover and cell motility.	Proline	173-180	protein tyrosine kinase 2	Homo sapiens	112-115
22952866-6	2012	PRINCIPAL FINDINGS: Using FAK-null fibroblasts stably reconstituted with green fluorescent protein (GFP) tagged FAK constructs, we find that FAK activity and FAK C-terminal proline-rich region 2 (PRR2) and PRR3 are required for FA turnover and cell motility.	Proline	173-180	protein tyrosine kinase 2	Homo sapiens	112-115
22952866-6	2012	PRINCIPAL FINDINGS: Using FAK-null fibroblasts stably reconstituted with green fluorescent protein (GFP) tagged FAK constructs, we find that FAK activity and FAK C-terminal proline-rich region 2 (PRR2) and PRR3 are required for FA turnover and cell motility.	Proline	173-180	protein tyrosine kinase 2	Homo sapiens	112-115
22984599-8	2012	Results from protein-protein interaction studies showed that T-Ag and Bag3 physically interact with each other through the zinc-finger of T-Ag and the proline rich domains of Bag3, and this interaction is important for the autophagic degradation of T-Ag.	Proline	151-158	long intergenic non-protein coding RNA 1194	Homo sapiens	61-65
22984599-8	2012	Results from protein-protein interaction studies showed that T-Ag and Bag3 physically interact with each other through the zinc-finger of T-Ag and the proline rich domains of Bag3, and this interaction is important for the autophagic degradation of T-Ag.	Proline	151-158	BAG cochaperone 3	Homo sapiens	70-74
22984599-8	2012	Results from protein-protein interaction studies showed that T-Ag and Bag3 physically interact with each other through the zinc-finger of T-Ag and the proline rich domains of Bag3, and this interaction is important for the autophagic degradation of T-Ag.	Proline	151-158	BAG cochaperone 3	Homo sapiens	175-179
23024808-3	2012	Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs).	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	106-109
22900083-3	2012	TbPin1 was identified as a novel class of Pin1-type parvulins from Trypanosoma brucei, containing a unique PPIase domain, which can catalyze the isomerization of phosphorylated Ser/Thr-Pro peptide bond.	Proline	185-188	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	2-6
23024808-3	2012	Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs).	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	81-104
23024808-5	2012	Based on these studies we conclude that PYCR1 and PYCR2, which are localized in the mitochondria, are primarily involved in conversion of glutamate to proline.	Proline	151-158	pyrroline-5-carboxylate reductase 1	Homo sapiens	40-45
23024808-5	2012	Based on these studies we conclude that PYCR1 and PYCR2, which are localized in the mitochondria, are primarily involved in conversion of glutamate to proline.	Proline	151-158	pyrroline-5-carboxylate reductase 2	Homo sapiens	50-55
22900083-3	2012	TbPin1 was identified as a novel class of Pin1-type parvulins from Trypanosoma brucei, containing a unique PPIase domain, which can catalyze the isomerization of phosphorylated Ser/Thr-Pro peptide bond.	Proline	185-188	FKBP prolyl isomerase 1B	Homo sapiens	107-113
22815893-8	2012	Upon NOD2 activation, SHIP-1 C-terminal proline rich domain (PRD) interacts with XIAP, thereby disturbing the interaction between XIAP and RIP2 in order to decrease NF-kappaB signaling.	Proline	40-47	nucleotide binding oligomerization domain containing 2	Homo sapiens	5-9
22848617-4	2012	Upk3l missing its C-terminal cytoplasmic domain or containing mutations in conserved tyrosine or proline residues did not rescue, or only partially rescued the effects of Upk3l depletion.	Proline	97-104	uroplakin 3b	Danio rerio	0-5
22911812-4	2012	Here we show that CsCyp complements the function of Cpr1 and Ess1, two yeast cyclophilins that regulate transcription by the isomerization of proline residues of the regulatory C-terminal domain (CTD) of RNA polymerase II.	Proline	142-149	Peptidyl-prolyl cis-trans isomerase-like	Citrus sinensis	18-23
22911812-4	2012	Here we show that CsCyp complements the function of Cpr1 and Ess1, two yeast cyclophilins that regulate transcription by the isomerization of proline residues of the regulatory C-terminal domain (CTD) of RNA polymerase II.	Proline	142-149	peptidylprolyl isomerase CPR1	Saccharomyces cerevisiae S288C	52-56
22911812-4	2012	Here we show that CsCyp complements the function of Cpr1 and Ess1, two yeast cyclophilins that regulate transcription by the isomerization of proline residues of the regulatory C-terminal domain (CTD) of RNA polymerase II.	Proline	142-149	peptidylprolyl isomerase ESS1	Saccharomyces cerevisiae S288C	61-65
22745667-2	2012	Sam68 comprises a central RNA-binding domain flanked by unstructured tails containing docking sites for signalling proteins including seven proline-rich sequences (denoted P0 to P6) as potential SH3-domain binding motifs.	Proline	140-147	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	0-5
22815893-8	2012	Upon NOD2 activation, SHIP-1 C-terminal proline rich domain (PRD) interacts with XIAP, thereby disturbing the interaction between XIAP and RIP2 in order to decrease NF-kappaB signaling.	Proline	40-47	inositol polyphosphate-5-phosphatase D	Homo sapiens	22-28
22815893-8	2012	Upon NOD2 activation, SHIP-1 C-terminal proline rich domain (PRD) interacts with XIAP, thereby disturbing the interaction between XIAP and RIP2 in order to decrease NF-kappaB signaling.	Proline	40-47	X-linked inhibitor of apoptosis	Homo sapiens	81-85
22815893-8	2012	Upon NOD2 activation, SHIP-1 C-terminal proline rich domain (PRD) interacts with XIAP, thereby disturbing the interaction between XIAP and RIP2 in order to decrease NF-kappaB signaling.	Proline	40-47	X-linked inhibitor of apoptosis	Homo sapiens	130-134
22815893-8	2012	Upon NOD2 activation, SHIP-1 C-terminal proline rich domain (PRD) interacts with XIAP, thereby disturbing the interaction between XIAP and RIP2 in order to decrease NF-kappaB signaling.	Proline	40-47	receptor interacting serine/threonine kinase 2	Homo sapiens	139-143
22272361-1	2012	BACKGROUND: The functional polymorphism (rs1800566) in the NQO1 gene, a 609C&gt;T substitution, leading to proline-to-serine amino-acid and enzyme activity changes, has been implicated in cancer risk, but individually published studies showed inconclusive results.	Proline	107-114	NAD(P)H quinone dehydrogenase 1	Homo sapiens	59-63
22540015-0	2012	The proline rich homeodomain protein PRH/Hhex forms stable oligomers that are highly resistant to denaturation.	Proline	4-11	hematopoietically expressed homeobox	Homo sapiens	37-40
22540015-0	2012	The proline rich homeodomain protein PRH/Hhex forms stable oligomers that are highly resistant to denaturation.	Proline	4-11	hematopoietically expressed homeobox	Homo sapiens	41-45
22540015-4	2012	PRINCIPAL FINDINGS: Here we show that the proline rich homeodomain protein PRH/Hhex forms predominantly octameric and/or hexadecameric species in solution as well as larger assemblies.	Proline	42-49	hematopoietically expressed homeobox	Homo sapiens	75-78
22540015-4	2012	PRINCIPAL FINDINGS: Here we show that the proline rich homeodomain protein PRH/Hhex forms predominantly octameric and/or hexadecameric species in solution as well as larger assemblies.	Proline	42-49	hematopoietically expressed homeobox	Homo sapiens	79-83
22442689-13	2012	Two special structural features (hydrophobic surface patch and cis/trans conformation for proline 52) may indicate a putative interaction site, and support an extra cellular signaling function for Diedel, which is in accordance with its proposed role as negative regulator of the JAK/STAT signaling pathway.	Proline	90-97	diedel	Drosophila melanogaster	197-203
21965677-6	2011	Mechanistically, a proline-rich segment in the carboxyl terminus of GILZ physically binds the p65 subunit of nuclear factor-kappaB and inhibits the transactivation of inflammatory cytokines.	Proline	19-26	TSC22 domain family member 3	Homo sapiens	68-72
22238672-4	2012	In addition, we show that the flanking SH3 domain binds to the proline-rich region of the C-terminus of Rac1, but not of RhoG.	Proline	63-70	Rac family small GTPase 1	Homo sapiens	104-108
22918593-6	2012	This proline-rich unstructured region contains the nuclear localization signal and a PCNA interaction motif that is critical for localization to replication foci and efficient joining of Okazaki fragments.	Proline	5-12	proliferating cell nuclear antigen	Homo sapiens	85-89
22312435-7	2012	ANOVA revealed that basal levels of II-2 and Ps-1 proteins, belonging to the basic proline-rich protein (bPRPs) family, were significantly higher in PROP super-taster than in nontaster un-stimulated saliva, and that PROP stimulation elicited a rapid increase in the levels of these same proteins only in PROP super-taster saliva.	Proline	83-90	taste 2 receptor member 62 pseudogene	Homo sapiens	45-49
22253690-5	2012	Adapter molecules such as Grb2 and CrkL interact with proline-rich region and activate multiple Bcr-Abl downstream signaling pathways that contribute to growth and survival.	Proline	54-61	growth factor receptor bound protein 2	Homo sapiens	26-30
22253690-5	2012	Adapter molecules such as Grb2 and CrkL interact with proline-rich region and activate multiple Bcr-Abl downstream signaling pathways that contribute to growth and survival.	Proline	54-61	CRK like proto-oncogene, adaptor protein	Homo sapiens	35-39
22253690-8	2012	Apoptin attributes such as SH2-like sequence similarity with CrkL SH2 domain, unique SH3 domain binding sequence, presence of proline-rich segments, and its nuclear affinity render the molecule capable of interaction with Bcr-Abl.	Proline	126-133	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	222-229
21965677-6	2011	Mechanistically, a proline-rich segment in the carboxyl terminus of GILZ physically binds the p65 subunit of nuclear factor-kappaB and inhibits the transactivation of inflammatory cytokines.	Proline	19-26	RELA proto-oncogene, NF-kB subunit	Homo sapiens	94-97
22185200-5	2011	This region of Vpr does not contain any proline residues but binds much more strongly to CypA than the previously characterized N-terminal binding domain of Vpr, and is thus the first protein binding domain to CypA described involving no proline residues.	Proline	40-47	Vpr	Human immunodeficiency virus 1	15-18
22185200-10	2011	A non-proline-containing 16-residue region of C-terminal Vpr which binds specifically to CypA with similar high affinity as full-length Vpr has been identified.	Proline	6-13	Vpr	Human immunodeficiency virus 1	57-60
22185200-10	2011	A non-proline-containing 16-residue region of C-terminal Vpr which binds specifically to CypA with similar high affinity as full-length Vpr has been identified.	Proline	6-13	peptidylprolyl isomerase A	Homo sapiens	89-93
22185200-10	2011	A non-proline-containing 16-residue region of C-terminal Vpr which binds specifically to CypA with similar high affinity as full-length Vpr has been identified.	Proline	6-13	Vpr	Human immunodeficiency virus 1	136-139
22185200-11	2011	The fact that this is the first non-proline containing binding motif of any protein found to bind to CypA, changes the view on how CypA is able to interact with other proteins.	Proline	36-43	peptidylprolyl isomerase A	Homo sapiens	101-105
22185200-11	2011	The fact that this is the first non-proline containing binding motif of any protein found to bind to CypA, changes the view on how CypA is able to interact with other proteins.	Proline	36-43	peptidylprolyl isomerase A	Homo sapiens	131-135
21986202-2	2011	We have demonstrated the modulating effect of noopept, a novel proline-containing dipeptide drug with nootropic and neuroprotective properties, on alpha-Syn oligomerization and fibrillation by using thioflavin T fluorescence, far-UV CD, and atomic force microscopy techniques.	Proline	63-70	synuclein alpha	Homo sapiens	147-156
21520031-10	2011	These findings together with other observations from literature on human cancers and the fact that the proline at codon 282 is extremely conserved in phylogenetically distant organisms (including Drosophila) suggest that the variant allele-282 could affect the biological function of WWOX, thereby predisposing individuals to thyroid cancer.	Proline	103-110	WW domain containing oxidoreductase	Drosophila melanogaster	284-288
22016392-4	2011	We show here that disruption of helix 8 in the B(2)R by either C-terminal truncation or just by mutation of a central amino acid (Lys-315) to a helix-breaking proline resulted in strong reduction of surface expression.	Proline	159-166	bradykinin receptor B2	Homo sapiens	47-52
22040654-0	2011	Steady-state kinetic mechanism of the proline:ubiquinone oxidoreductase activity of proline utilization A (PutA) from Escherichia coli.	Proline	38-45	oxidoreductase	Escherichia coli	57-71
22040654-0	2011	Steady-state kinetic mechanism of the proline:ubiquinone oxidoreductase activity of proline utilization A (PutA) from Escherichia coli.	Proline	84-91	oxidoreductase	Escherichia coli	57-71
22040654-8	2011	In summary, the kinetic data reported here, along with analysis of the crystal structure data for the PRODH domain, suggest that the proline:ubiquinone oxidoreductase reaction of PutA occurs via a rapid equilibrium ping-pong mechanism with proline and ubiquinone binding at two distinct sites.	Proline	133-140	oxidoreductase	Escherichia coli	152-166
22040654-8	2011	In summary, the kinetic data reported here, along with analysis of the crystal structure data for the PRODH domain, suggest that the proline:ubiquinone oxidoreductase reaction of PutA occurs via a rapid equilibrium ping-pong mechanism with proline and ubiquinone binding at two distinct sites.	Proline	240-247	oxidoreductase	Escherichia coli	152-166
21790734-3	2011	Two mutations (A230T and E250Q) in the PSTPIP1 gene, encoding proline-serine-threonine phosphatase-interacting protein (PSTPIP)1 have been identified in patients with PAPA (pyogenic sterile arthritis with PG and acne) syndrome, a rare autoinflammatory disorder with autosomal dominant inheritance.	Proline	62-69	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	39-46
22119435-1	2011	Opiorphin, QRFSR-peptide, is a mature product of the PROL1 (proline rich, lacrimal 1) protein that showed beneficial effects in pain management, antidepressant-like actions as well as involvement in colonic motility and erectile physiology.	Proline	60-67	opiorphin prepropeptide	Homo sapiens	0-9
22119435-1	2011	Opiorphin, QRFSR-peptide, is a mature product of the PROL1 (proline rich, lacrimal 1) protein that showed beneficial effects in pain management, antidepressant-like actions as well as involvement in colonic motility and erectile physiology.	Proline	60-67	opiorphin prepropeptide	Homo sapiens	53-58
22134239-2	2011	High oxygen tension promotes proteosomal degradation of HIF-1alpha via a pathway that requires hydroxylation of prolines 402 and 564.	Proline	112-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
21501141-6	2011	SLC36A2 is expressed at the apical surface of the human renal proximal tubule where it functions in the reabsorption of glycine, proline and hydroxyproline.	Proline	129-136	solute carrier family 36 member 2	Homo sapiens	0-7
21501141-10	2011	SLC36A4 is widely distributed at the mRNA level and is a high-affinity (K(m) 2-3 microM) transporter for proline and tryptophan.	Proline	105-112	solute carrier family 36 member 4	Homo sapiens	0-7
21920940-5	2011	Profilin2a binds to a stretch of proline residues in SMN, which is heavily impaired by a novel SMN2 missense mutation (S230L) derived from a SMA patient.	Proline	33-40	survival of motor neuron 1, telomeric	Homo sapiens	53-56
21920940-5	2011	Profilin2a binds to a stretch of proline residues in SMN, which is heavily impaired by a novel SMN2 missense mutation (S230L) derived from a SMA patient.	Proline	33-40	survival of motor neuron 2, centromeric	Homo sapiens	95-99
21951999-8	2011	Mutations to alanine of proline residues in ATF4 that satisfied hydroxylation consensus by PHDs did not affect binding activity of ATF4 to PHD1 and PHD3.	Proline	24-31	activating transcription factor 4	Homo sapiens	44-48
22199295-7	2011	Individuals with the C (Pro) allele at p53 codon 72 had a 1.6-fold increased odds ratio of endometriosis, and those with Arg/Pro and Pro/Pro genotypes for p53 codon 72 had a 1.84- and 2.74-fold (95% confidence interval=1.17-2.92 and 1.58-4.74) increased risk of endometriosis compared to those with Arg/Arg, respectively.	Proline	24-27	tumor protein p53	Homo sapiens	39-42
22199132-4	2011	The k(cat)/K(m) values of Nma-Phe-His-Lys(Dnp), Nma-His-Pro-Phe-Lys(Dnp)-Pro, and Hip-His-Leu were 5.12, 1.90, and 0.80 microM(-1) s(-1) for rabbit lung ACE, and 16.0, 7.36, and 0.30 microM(-1) s(-1) for recombinant human (rh)-ACE, respectively.	Proline	56-59	angiotensin-converting enzyme	Oryctolagus cuniculus	153-156
22199132-4	2011	The k(cat)/K(m) values of Nma-Phe-His-Lys(Dnp), Nma-His-Pro-Phe-Lys(Dnp)-Pro, and Hip-His-Leu were 5.12, 1.90, and 0.80 microM(-1) s(-1) for rabbit lung ACE, and 16.0, 7.36, and 0.30 microM(-1) s(-1) for recombinant human (rh)-ACE, respectively.	Proline	56-59	angiotensin I converting enzyme	Homo sapiens	227-230
22199132-4	2011	The k(cat)/K(m) values of Nma-Phe-His-Lys(Dnp), Nma-His-Pro-Phe-Lys(Dnp)-Pro, and Hip-His-Leu were 5.12, 1.90, and 0.80 microM(-1) s(-1) for rabbit lung ACE, and 16.0, 7.36, and 0.30 microM(-1) s(-1) for recombinant human (rh)-ACE, respectively.	Proline	73-76	angiotensin-converting enzyme	Oryctolagus cuniculus	153-156
22199132-4	2011	The k(cat)/K(m) values of Nma-Phe-His-Lys(Dnp), Nma-His-Pro-Phe-Lys(Dnp)-Pro, and Hip-His-Leu were 5.12, 1.90, and 0.80 microM(-1) s(-1) for rabbit lung ACE, and 16.0, 7.36, and 0.30 microM(-1) s(-1) for recombinant human (rh)-ACE, respectively.	Proline	73-76	angiotensin I converting enzyme	Homo sapiens	227-230
21750908-1	2011	Mutation of galectin-3 at position 191 (rs4644) substituting proline to histidine (gal-3H(64)) resulted in the acquisition of resistance to drug-induced apoptosis by breast cancer cells.	Proline	61-68	galectin 3	Homo sapiens	12-22
21790734-3	2011	Two mutations (A230T and E250Q) in the PSTPIP1 gene, encoding proline-serine-threonine phosphatase-interacting protein (PSTPIP)1 have been identified in patients with PAPA (pyogenic sterile arthritis with PG and acne) syndrome, a rare autoinflammatory disorder with autosomal dominant inheritance.	Proline	62-69	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	120-128
21255264-5	2011	PHD2 hydroxylates beta-arrestin 2 at the proline (Pro)(176), Pro(179) and Pro(181) sites, which retards the recruitment of beta-arrestin 2 to the plasma membrane and inhibits subsequent co-internalization with beta(2) -AR into the cytosol.	Proline	41-48	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
22010140-3	2011	Molecular analysis of the PLCzeta gene of a male patient with oocyte activation deficiency has previously identified a point mutation causing a histidine to proline substitution at PLCzeta residue 398 (PLCzeta(H398P)), leading to abnormal Ca(2+) release profiles and reduced oocyte activation efficiency.	Proline	157-164	phospholipase C zeta 1	Homo sapiens	26-33
22010140-3	2011	Molecular analysis of the PLCzeta gene of a male patient with oocyte activation deficiency has previously identified a point mutation causing a histidine to proline substitution at PLCzeta residue 398 (PLCzeta(H398P)), leading to abnormal Ca(2+) release profiles and reduced oocyte activation efficiency.	Proline	157-164	phospholipase C zeta 1	Homo sapiens	181-188
22010140-3	2011	Molecular analysis of the PLCzeta gene of a male patient with oocyte activation deficiency has previously identified a point mutation causing a histidine to proline substitution at PLCzeta residue 398 (PLCzeta(H398P)), leading to abnormal Ca(2+) release profiles and reduced oocyte activation efficiency.	Proline	157-164	phospholipase C zeta 1	Homo sapiens	181-188
21907823-2	2011	Reps2 contains Eps15 homology (EH) domains, proline-rich regions, and a coiled-coil domain that engage in several protein-protein interactions to coordinate the internalization of various receptors with molecular signaling.	Proline	44-51	RALBP1 associated Eps domain containing 2	Homo sapiens	0-5
21255264-5	2011	PHD2 hydroxylates beta-arrestin 2 at the proline (Pro)(176), Pro(179) and Pro(181) sites, which retards the recruitment of beta-arrestin 2 to the plasma membrane and inhibits subsequent co-internalization with beta(2) -AR into the cytosol.	Proline	41-48	arrestin beta 2	Homo sapiens	18-33
21255264-5	2011	PHD2 hydroxylates beta-arrestin 2 at the proline (Pro)(176), Pro(179) and Pro(181) sites, which retards the recruitment of beta-arrestin 2 to the plasma membrane and inhibits subsequent co-internalization with beta(2) -AR into the cytosol.	Proline	41-48	arrestin beta 2	Homo sapiens	123-138
21255264-5	2011	PHD2 hydroxylates beta-arrestin 2 at the proline (Pro)(176), Pro(179) and Pro(181) sites, which retards the recruitment of beta-arrestin 2 to the plasma membrane and inhibits subsequent co-internalization with beta(2) -AR into the cytosol.	Proline	50-53	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
21255264-5	2011	PHD2 hydroxylates beta-arrestin 2 at the proline (Pro)(176), Pro(179) and Pro(181) sites, which retards the recruitment of beta-arrestin 2 to the plasma membrane and inhibits subsequent co-internalization with beta(2) -AR into the cytosol.	Proline	50-53	arrestin beta 2	Homo sapiens	18-33
21255264-5	2011	PHD2 hydroxylates beta-arrestin 2 at the proline (Pro)(176), Pro(179) and Pro(181) sites, which retards the recruitment of beta-arrestin 2 to the plasma membrane and inhibits subsequent co-internalization with beta(2) -AR into the cytosol.	Proline	50-53	arrestin beta 2	Homo sapiens	123-138
21255264-5	2011	PHD2 hydroxylates beta-arrestin 2 at the proline (Pro)(176), Pro(179) and Pro(181) sites, which retards the recruitment of beta-arrestin 2 to the plasma membrane and inhibits subsequent co-internalization with beta(2) -AR into the cytosol.	Proline	61-64	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
21255264-5	2011	PHD2 hydroxylates beta-arrestin 2 at the proline (Pro)(176), Pro(179) and Pro(181) sites, which retards the recruitment of beta-arrestin 2 to the plasma membrane and inhibits subsequent co-internalization with beta(2) -AR into the cytosol.	Proline	61-64	arrestin beta 2	Homo sapiens	18-33
21255264-5	2011	PHD2 hydroxylates beta-arrestin 2 at the proline (Pro)(176), Pro(179) and Pro(181) sites, which retards the recruitment of beta-arrestin 2 to the plasma membrane and inhibits subsequent co-internalization with beta(2) -AR into the cytosol.	Proline	61-64	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
21255264-5	2011	PHD2 hydroxylates beta-arrestin 2 at the proline (Pro)(176), Pro(179) and Pro(181) sites, which retards the recruitment of beta-arrestin 2 to the plasma membrane and inhibits subsequent co-internalization with beta(2) -AR into the cytosol.	Proline	61-64	arrestin beta 2	Homo sapiens	18-33
21965294-2	2011	Karyopherin beta2 or transportin recognizes a proline-tyrosine nuclear localization signal (PY-NLS) in the N-terminal tail of NXF1 and imports it into the nucleus.	Proline	46-53	transportin 1	Homo sapiens	0-17
21965294-2	2011	Karyopherin beta2 or transportin recognizes a proline-tyrosine nuclear localization signal (PY-NLS) in the N-terminal tail of NXF1 and imports it into the nucleus.	Proline	46-53	nuclear RNA export factor 1	Homo sapiens	126-130
21792675-5	2011	Results show that proline impairs cognitive performance, decreases BDNF in cerebral cortex and hippocampus and increases AChE activity in hippocampus.	Proline	18-25	brain-derived neurotrophic factor	Rattus norvegicus	67-71
21792675-5	2011	Results show that proline impairs cognitive performance, decreases BDNF in cerebral cortex and hippocampus and increases AChE activity in hippocampus.	Proline	18-25	acetylcholinesterase	Rattus norvegicus	121-125
21945527-4	2011	Each code variant showed stronger binding to its putative cognate site than to the wild-type site, except some variants containing proline at position 27; each also bound its cognate site better than wild-type Cro bound the same site.	Proline	131-138	cro	Escherichia virus Lambda	210-213
21999103-1	2011	A chemo- and stereoselective asymmetric direct cross-aldol reaction between aliphatic aldehydes and alpha-chloroaldehydes has been developed as a method for the formation of the sole cross-aldol adduct with both enantio- and diastereocontrol, and either anti- or syn-aldol adducts were obtained in good to excellent stereoselectivities by use of proline or a novel axially chiral amino sulfonamide as catalyst.	Proline	346-353	synemin	Homo sapiens	263-266
21963180-3	2011	In order to calculate the cis-trans isomerization rate constants of Ang I on the stationary phase"s surface, the first and second moments of the proline peptide elution profiles were determined.	Proline	145-152	angiotensinogen	Homo sapiens	68-73
22102226-6	2011	However, binding studies with two classes of proline-rich ligand peptides demonstrate that the ligand-binding specificity differs slightly between the SH3 domains of human p85beta and p85alpha, despite their high structural similarity.	Proline	45-52	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	172-179
22078467-6	2011	Cortactin, an F-actin associated protein and a substrate of Src kinase, was found to interact with FAK through its SH3 domain and the C-terminal proline-rich regions of FAK.	Proline	145-152	cortactin	Homo sapiens	0-9
22078467-6	2011	Cortactin, an F-actin associated protein and a substrate of Src kinase, was found to interact with FAK through its SH3 domain and the C-terminal proline-rich regions of FAK.	Proline	145-152	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	60-63
22078467-6	2011	Cortactin, an F-actin associated protein and a substrate of Src kinase, was found to interact with FAK through its SH3 domain and the C-terminal proline-rich regions of FAK.	Proline	145-152	protein tyrosine kinase 2	Homo sapiens	99-102
22078467-6	2011	Cortactin, an F-actin associated protein and a substrate of Src kinase, was found to interact with FAK through its SH3 domain and the C-terminal proline-rich regions of FAK.	Proline	145-152	protein tyrosine kinase 2	Homo sapiens	169-172
21980916-8	2011	Three additional reduced amides, with Thr replacing Ser and l- or d-pipecolate (Pip) replacing Pro, were slightly weaker inhibitors of Pin1.	Proline	95-98	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	135-139
22001206-1	2011	The dipeptidyl peptidase (DPP) family members, including DPP-IV, DPP8, DPP9 and others, cleave the peptide bond after the penultimate proline residue and are drug target rich.	Proline	134-141	dipeptidyl peptidase 4	Homo sapiens	57-63
22001206-1	2011	The dipeptidyl peptidase (DPP) family members, including DPP-IV, DPP8, DPP9 and others, cleave the peptide bond after the penultimate proline residue and are drug target rich.	Proline	134-141	dipeptidyl peptidase 8	Homo sapiens	65-69
22001206-1	2011	The dipeptidyl peptidase (DPP) family members, including DPP-IV, DPP8, DPP9 and others, cleave the peptide bond after the penultimate proline residue and are drug target rich.	Proline	134-141	dipeptidyl peptidase 9	Homo sapiens	71-75
22049418-2	2011	Cdk5 is a proline-directed serine/threonine kinase whose activation by the p25 protein has been implicated in a number of neurodegenerative disorders.	Proline	10-17	cyclin-dependent kinase 5	Mus musculus	0-4
22049418-2	2011	Cdk5 is a proline-directed serine/threonine kinase whose activation by the p25 protein has been implicated in a number of neurodegenerative disorders.	Proline	10-17	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	75-78
21967280-2	2011	Human Pin1 is central to many of these cell signaling pathways in normal and aberrant subcellular processes, catalyzing cis-trans isomerization of the peptide omega-bond in phosphorylated serine/threonine-proline motifs in many proteins.	Proline	205-212	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	6-10
21917930-4	2011	First, we show that many of the proteins that define the cellular proteome interacting with FBP21-WW1-WW2 contain multiple proline-rich motifs.	Proline	123-130	WW domain binding protein 4	Homo sapiens	92-97
22102226-6	2011	However, binding studies with two classes of proline-rich ligand peptides demonstrate that the ligand-binding specificity differs slightly between the SH3 domains of human p85beta and p85alpha, despite their high structural similarity.	Proline	45-52	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	184-192
21964860-2	2011	The cartilage-associated protein (CRTAP) is part of a heterotrimeric complex (together with prolyl-3-hydroxylase-1 [P3H1] and cyclophilin B) that 3-hydroxylates the alpha 1 chain of collagen type I at proline residue 986 and plays a collagen chaperon role.	Proline	201-208	prolyl 3-hydroxylase 1	Homo sapiens	116-120
21964860-2	2011	The cartilage-associated protein (CRTAP) is part of a heterotrimeric complex (together with prolyl-3-hydroxylase-1 [P3H1] and cyclophilin B) that 3-hydroxylates the alpha 1 chain of collagen type I at proline residue 986 and plays a collagen chaperon role.	Proline	201-208	cartilage associated protein	Homo sapiens	4-32
21595775-4	2011	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in EC were 39.4%, 45.6%, and 15.0%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively.	Proline	60-63	tumor protein p53	Homo sapiens	19-22
21964860-2	2011	The cartilage-associated protein (CRTAP) is part of a heterotrimeric complex (together with prolyl-3-hydroxylase-1 [P3H1] and cyclophilin B) that 3-hydroxylates the alpha 1 chain of collagen type I at proline residue 986 and plays a collagen chaperon role.	Proline	201-208	cartilage associated protein	Homo sapiens	34-39
21964860-2	2011	The cartilage-associated protein (CRTAP) is part of a heterotrimeric complex (together with prolyl-3-hydroxylase-1 [P3H1] and cyclophilin B) that 3-hydroxylates the alpha 1 chain of collagen type I at proline residue 986 and plays a collagen chaperon role.	Proline	201-208	prolyl 3-hydroxylase 1	Homo sapiens	92-114
21819963-3	2011	In contrast, an N-terminally truncated Tat protein (aa 35-86) that lacks the structurally defined proline- and cysteine-rich region as well as the highly conserved tryptophan residue at position 11 generates pores in artificial POPC-membranes, through which a water-soluble dye up to a size of 10kDa can pass.	Proline	98-105	tyrosine aminotransferase	Homo sapiens	39-42
22423487-8	2011	Significant increases of the peak area of apolipoprotein CI (reduced form with segregated threonine and proline) and C4 enzymes of the complement system, and fibrinogen on the first day after the experiment can be related to changes in motor activities of the subjects.	Proline	104-111	apolipoprotein C1	Homo sapiens	42-59
21732913-0	2011	Interaction between the SH3 domain of Src family kinases and the proline-rich motif of HTLV-1 p13: a novel mechanism underlying delivery of Src family kinases to mitochondria.	Proline	65-72	H3 histone pseudogene 6	Homo sapiens	94-97
21732913-2	2011	We demonstrate in the present study for the first time that p13, an accessory protein encoded by the HTLV-1 (human T-cell leukaemia virus type 1), binds the SH3 domain of SFKs via its C-terminal proline-rich motif, forming a stable heterodimer that translocates to mitochondria by virtue of its N-terminal mitochondrial localization signal.	Proline	195-202	H3 histone pseudogene 6	Homo sapiens	60-63
21972973-8	2011	Cathepsin L deficiency predominantly reduced the magnitude of collagenous cleavage sites C-terminal to a proline residue.	Proline	105-112	cathepsin L	Mus musculus	0-11
21595775-4	2011	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in EC were 39.4%, 45.6%, and 15.0%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively.	Proline	69-72	tumor protein p53	Homo sapiens	19-22
21595775-4	2011	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in EC were 39.4%, 45.6%, and 15.0%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively.	Proline	69-72	tumor protein p53	Homo sapiens	19-22
21841506-7	2011	Pairwise combination analysis showed that patients carrying the variant P53 Pro/Pro-P73 GC/GC or P53 Pro/Pro-MDM2 GG genotypes had survival time only half of that for those carrying the wild-type genotypes, with hazard ratio being 2.47 (95% CI, 1.20-5.10) and 2.00 (95% CI, 1.15-3.46), respectively.	Proline	76-79	tumor protein p53	Homo sapiens	72-75
21963115-3	2011	In this study we investigate whether the notoriously low affinity inhibitory interaction of linear proline-containing peptides with the active site of CypA can be increased through a combination of a high cis/trans ratio and a negatively charged C-terminus as has been recently reported for Trp-Gly-Pro.	Proline	99-106	peptidylprolyl isomerase A	Homo sapiens	151-155
21949020-3	2011	The N terminus of SLP-76, which contains three tyrosines that serve as docking sites for SH2 domain-containing proteins, and the central proline-rich region of SLP-76 have been well studied and are known to be important for both thymocyte selection and activation of peripheral T cells.	Proline	137-144	lymphocyte cytosolic protein 2	Mus musculus	160-166
21831886-6	2011	Three mutants containing different proline substitutions (P101H, P101R and P152R) were severely affected only in heterochromatin clustering and located far away from the DNA interface in the MeCP2 methyl-binding domain structure.	Proline	35-42	methyl-CpG binding protein 2	Homo sapiens	191-196
21695714-0	2011	A proline rich acidic protein PRAP identified from uterine luminal fluid of estrous mice is able to enhance the estrogen responsiveness of Ishikawa cells.	Proline	2-9	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	30-34
21841506-7	2011	Pairwise combination analysis showed that patients carrying the variant P53 Pro/Pro-P73 GC/GC or P53 Pro/Pro-MDM2 GG genotypes had survival time only half of that for those carrying the wild-type genotypes, with hazard ratio being 2.47 (95% CI, 1.20-5.10) and 2.00 (95% CI, 1.15-3.46), respectively.	Proline	76-79	tumor protein p73	Homo sapiens	84-87
21982763-1	2011	The peptidyl-proline isomerase, protein never in mitosis gene A interacting-1 (PIN1) binds and isomerizes proteins phosphorylated on serine/threonine before a proline.	Proline	13-20	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	32-77
22057999-9	2011	Meta-analysis results  showed that the Pro allele and Pro carrier (Arg/Pro + Pro/Pro) of p53 codon 72  polymorphism were significantly related with endometrial cancer risk (OR =  1.25, 95%CI = 1.10-1.41, P = 0.0005; OR = 1.34, 95%CI = 1.12-1.59, P = 0.001,  respectively).	Proline	39-42	tumor protein p53	Homo sapiens	89-92
22057999-9	2011	Meta-analysis results  showed that the Pro allele and Pro carrier (Arg/Pro + Pro/Pro) of p53 codon 72  polymorphism were significantly related with endometrial cancer risk (OR =  1.25, 95%CI = 1.10-1.41, P = 0.0005; OR = 1.34, 95%CI = 1.12-1.59, P = 0.001,  respectively).	Proline	54-57	tumor protein p53	Homo sapiens	89-92
22057999-9	2011	Meta-analysis results  showed that the Pro allele and Pro carrier (Arg/Pro + Pro/Pro) of p53 codon 72  polymorphism were significantly related with endometrial cancer risk (OR =  1.25, 95%CI = 1.10-1.41, P = 0.0005; OR = 1.34, 95%CI = 1.12-1.59, P = 0.001,  respectively).	Proline	54-57	tumor protein p53	Homo sapiens	89-92
22057999-11	2011	We  concluded that the Pro allele (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism  is a potential risk factor for endometrial cancer.	Proline	23-26	tumor protein p53	Homo sapiens	57-60
22057999-11	2011	We  concluded that the Pro allele (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism  is a potential risk factor for endometrial cancer.	Proline	39-42	tumor protein p53	Homo sapiens	57-60
22057999-11	2011	We  concluded that the Pro allele (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism  is a potential risk factor for endometrial cancer.	Proline	39-42	tumor protein p53	Homo sapiens	57-60
21880777-10	2011	These observations imply that the combined effects of proline and negatively charged residues within the PEPE peptide are essential to promote the cleavage of 2K from NS4A, which is a prerequisite for efficient WNV replication.	Proline	54-61	peptidase E	Homo sapiens	105-109
22645651-5	2011	Analysis of PINKtide variants reveal that PINK1 phosphorylates serine or threonine, but not tyrosine, and we show that PINK1 exhibits a preference for a proline at the +1 position relative to the phosphorylation site.	Proline	153-160	PTEN induced kinase 1	Homo sapiens	119-124
22848287-1	2011	Peptidyl-prolyl isomerase Pin1 specifically catalyzes the cis/trans-isomerization of proline in the target sequence of phosphorylated Ser/Thr-Pro in over 50 critical regulatory proteins.	Proline	85-92	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	26-30
22848287-1	2011	Peptidyl-prolyl isomerase Pin1 specifically catalyzes the cis/trans-isomerization of proline in the target sequence of phosphorylated Ser/Thr-Pro in over 50 critical regulatory proteins.	Proline	142-145	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	26-30
22114558-3	2011	Despite the lack of overall homology we noted a carboxyterminal proline-rich sequence motif shared by many alphaviral nsP3 proteins, and found it to serve as a preferred target site for the Src-homology 3 (SH3) domains of amphiphysin-1 and -2.	Proline	64-71	SH2 domain containing 3C	Homo sapiens	118-122
21982774-5	2011	The proline hydroxylation is unique for invertebrate neuropeptides, while it has been described in the vertebrate gonadotropin-releasing hormone (GnRH).	Proline	4-11	gonadotropin releasing hormone 1	Homo sapiens	114-144
21982774-5	2011	The proline hydroxylation is unique for invertebrate neuropeptides, while it has been described in the vertebrate gonadotropin-releasing hormone (GnRH).	Proline	4-11	gonadotropin releasing hormone 1	Homo sapiens	146-150
21982763-1	2011	The peptidyl-proline isomerase, protein never in mitosis gene A interacting-1 (PIN1) binds and isomerizes proteins phosphorylated on serine/threonine before a proline.	Proline	13-20	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	79-83
21982763-14	2011	PIN1 may act directly via phosphorylated serine/threonine-proline motifs in calpastatin, or indirectly via other PIN1 substrates that control calpastatin.	Proline	58-65	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
21987804-8	2011	Interestingly, mutation to aspartate (G98D) or proline (G98P) caused constitutive channel activation in a STIM1-independent manner.	Proline	47-54	stromal interaction molecule 1	Homo sapiens	106-111
21923188-6	2011	Especially, the proline residue in the C-terminal end strongly enhanced ACE inhibition.	Proline	16-23	angiotensin I converting enzyme	Homo sapiens	72-75
22046147-2	2011	The functional localization and oligomerization of AChE T variant are depending primarily on the association of their anchoring partners, either collagen tail (ColQ) or proline-rich membrane anchor (PRiMA).	Proline	169-176	acetylcholinesterase (Cartwright blood group)	Gallus gallus	51-55
21972418-4	2011	Although global OSR1(-/-) mice were embryonically lethal, OSR1(+/-) mice had low BP associated with reduced phosphorylated (p) STE20 (sterile 20)/SPS1-related proline/alanine-rich kinase (SPAK) and p-NKCC1 abundance in aortic tissue and attenuated p-NKCC2 abundance with increased total and p-NCC expression in the kidney.	Proline	159-166	odd-skipped related transcription factor 1	Mus musculus	58-62
21776983-0	2011	Dissecting the functions of conserved prolines within transmembrane helices of the D2 dopamine receptor.	Proline	38-46	dopamine receptor D2	Homo sapiens	83-103
21776983-2	2011	Here we use unnatural amino acid mutagenesis, employing alpha-hydroxy acids and proline analogues, to examine the functional roles of five proline residues in the transmembrane helices of the D2 dopamine receptor.	Proline	139-146	dopamine receptor D2	Homo sapiens	192-212
21958056-1	2011	Proline anthranilamide-based pseudopeptides were shown to be effective organocatalysts for enantioselective direct aldol reactions of a selection of aldehydes with various ketones with excellent yield, enantioselectivity up to 99% and anti to syn diastereoselectivity up to 25:1.	Proline	0-7	synemin	Homo sapiens	243-246
21745501-5	2011	The binding is mediated by the proline-rich sequence of Tat and the SH3 domain of Grb2.	Proline	31-38	tyrosine aminotransferase	Homo sapiens	56-59
21865164-9	2011	Mutagenesis of the conserved prolines to alanines enhanced importin-alpha binding to PKCdelta and induced its nuclear import in resting cells.	Proline	29-37	protein kinase C delta	Homo sapiens	85-93
21910444-0	2011	Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau.	Proline	21-28	PHD finger protein 1	Homo sapiens	79-83
21910444-0	2011	Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau.	Proline	21-28	microtubule associated protein tau	Homo sapiens	108-111
21964608-3	2011	We identified a conserved proline-rich motif in V3 required for association with CD28 and immunological synapse localization.	Proline	26-33	CD28 molecule	Homo sapiens	81-85
21195118-5	2011	We now report that dynamin II from rat lung is phosphorylated to a low stoichiometry on a single major site, Ser-764, in the proline-rich domain.	Proline	125-132	dynamin 2	Homo sapiens	19-29
21195118-9	2011	Cyclin-dependent kinase 1 phosphorylated full length dynamin II and Glutathione-S-Transferase-tagged-dynamin II-proline-rich domain in vitro, and mutation of Ser-764 to alanine reduced proline-rich domain phosphorylation by 80%, supporting that there is only a single major phosphosite.	Proline	112-119	dynamin 2	Homo sapiens	101-111
21195118-9	2011	Cyclin-dependent kinase 1 phosphorylated full length dynamin II and Glutathione-S-Transferase-tagged-dynamin II-proline-rich domain in vitro, and mutation of Ser-764 to alanine reduced proline-rich domain phosphorylation by 80%, supporting that there is only a single major phosphosite.	Proline	185-192	dynamin 2	Homo sapiens	101-111
21882820-1	2011	Protein tyrosine phosphatases (PTPs) catalyze the dephosphorylation of tyrosine residues, a process that involves a conserved tryptophan-proline-aspartate (WPD) loop in catalysis.	Proline	137-144	6-pyruvoyltetrahydropterin synthase	Homo sapiens	0-29
21882820-1	2011	Protein tyrosine phosphatases (PTPs) catalyze the dephosphorylation of tyrosine residues, a process that involves a conserved tryptophan-proline-aspartate (WPD) loop in catalysis.	Proline	137-144	6-pyruvoyltetrahydropterin synthase	Homo sapiens	31-35
21745501-5	2011	The binding is mediated by the proline-rich sequence of Tat and the SH3 domain of Grb2.	Proline	31-38	growth factor receptor bound protein 2	Homo sapiens	82-86
21830225-2	2011	The proline-arginine motif PXXXPR in c-Cbl and SH3 domains of CIN85 are essential to this interaction.	Proline	4-11	Cbl proto-oncogene	Homo sapiens	37-42
21903398-4	2011	These elements were then incorporated by solid-phase synthesis into pentapeptide aldehydes 33a-v. Proline-based compound 33h bearing a bulky 3-(S)-substituent displayed advantageous characteristics in biochemical and cellular assays with 20- to 60-fold increased selectivity for caspase-2 and ~200-fold decreased caspase-3 potency compared to the reference inhibitor 1.	Proline	98-105	caspase 2	Homo sapiens	279-288
21903398-4	2011	These elements were then incorporated by solid-phase synthesis into pentapeptide aldehydes 33a-v. Proline-based compound 33h bearing a bulky 3-(S)-substituent displayed advantageous characteristics in biochemical and cellular assays with 20- to 60-fold increased selectivity for caspase-2 and ~200-fold decreased caspase-3 potency compared to the reference inhibitor 1.	Proline	98-105	caspase 3	Homo sapiens	313-322
21903398-4	2011	These elements were then incorporated by solid-phase synthesis into pentapeptide aldehydes 33a-v. Proline-based compound 33h bearing a bulky 3-(S)-substituent displayed advantageous characteristics in biochemical and cellular assays with 20- to 60-fold increased selectivity for caspase-2 and ~200-fold decreased caspase-3 potency compared to the reference inhibitor 1.	Proline	98-105	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	357-368
22485205-0	2011	Activities of proline-specific peptidases in brain structures of rats with experimental anxiety-depressive state caused by administration of dipeptidyl peptidase IV inhibitor in the early postnatal period.	Proline	14-21	dipeptidylpeptidase 4	Rattus norvegicus	141-164
21830225-2	2011	The proline-arginine motif PXXXPR in c-Cbl and SH3 domains of CIN85 are essential to this interaction.	Proline	4-11	SH3 domain containing kinase binding protein 1	Homo sapiens	62-67
21849258-5	2011	Our findings confirm the association between F12 gene mutations modifying the proline-rich region of the FXII protein and hereditary angioedema with normal C1-inhibitor.	Proline	78-85	coagulation factor XII	Homo sapiens	45-48
21664272-3	2011	The first and the third SH3 domains of Nck1 and the NH(2)-terminal proline-rich sequence of RasGAP contribute most to the complex formation causing direct molecular interaction between the two proteins.	Proline	67-74	NCK adaptor protein 1	Homo sapiens	39-43
21664272-3	2011	The first and the third SH3 domains of Nck1 and the NH(2)-terminal proline-rich sequence of RasGAP contribute most to the complex formation causing direct molecular interaction between the two proteins.	Proline	67-74	RAS p21 protein activator 1	Homo sapiens	92-98
21680116-4	2011	A complex mRNA splicing pattern was also evidenced for bovine CD46, generating three different serine-threonine-proline segments and five different cytoplasmic domains.	Proline	112-119	membrane cofactor protein	Bos taurus	62-66
22103837-4	2011	Accordingly, the proline-rich SH3 binding site, the "PxxP motif", is one of the key functional determinants of Nef.	Proline	17-24	TNFAIP3 interacting protein 1	Mus musculus	111-114
21764651-1	2011	Pin1 specifically recognizes and catalyzes the cis-trans isomerization of phosphorylated-Ser/Thr-Pro bonds, which modulate the stability, localization, and function of numerous Pin1 targets involved in tumor progression.	Proline	97-100	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
21764651-1	2011	Pin1 specifically recognizes and catalyzes the cis-trans isomerization of phosphorylated-Ser/Thr-Pro bonds, which modulate the stability, localization, and function of numerous Pin1 targets involved in tumor progression.	Proline	97-100	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	177-181
21852393-4	2011	Here, we demonstrate that Ngn2 is phosphorylated on multiple serine-proline sites in response to rising cyclin-dependent kinase (cdk) levels.	Proline	68-75	neurogenin 2	Homo sapiens	26-30
21875153-6	2011	In the protease bound-antithrombin-pentasaccharide complex Lys 114, Pro 12 and Lys 125 form important hydrogen bonding interactions.	Proline	68-71	serpin family C member 1	Homo sapiens	22-34
21264484-0	2011	DFT and MP2 investigations of L-proline and its hydrated complexes.	Proline	30-39	tryptase pseudogene 1	Homo sapiens	8-11
21264484-1	2011	A theoretical study of L-proline-nH(2)O (n = 1-3) has been performed using the hybrid DFT-B3LYP and MP2 methods together with the 6-311++G(d,p) basis set.	Proline	23-32	tryptase pseudogene 1	Homo sapiens	100-103
21852138-1	2011	Pin1 is a highly conserved enzyme that only isomerizes specific phosphorylated Ser/Thr-Pro bonds in certain proteins, thereby inducing conformational changes.	Proline	87-90	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
21834515-0	2011	Proline in transmembrane domain of type II protein DPP-IV governs its translocation behavior through endoplasmic reticulum.	Proline	0-7	dipeptidyl peptidase 4	Homo sapiens	51-57
21884682-4	2011	JCAD is a ~145 kDa protein without any known domains but contains a proline-rich region.	Proline	68-75	junctional cadherin 5 associated	Mus musculus	0-4
21943426-8	2011	Further local structure analyses revealed that, guided by all-atom MD ensemble of fragments, the p53 N-terminal domain ensemble was biased to kinked structures in the AD1 region and biased to extended conformers in a proline-rich region and these biases contributed to improvement of the reproduction of the experiments.	Proline	217-224	tumor protein p53	Homo sapiens	97-100
21828049-3	2011	Herein, we show that MerTK is cleaved at proline 485 in murine macrophages.	Proline	41-48	MER proto-oncogene tyrosine kinase	Mus musculus	21-26
21828049-4	2011	Site-directed deletion of 6 amino acids spanning proline 485 rendered MerTK resistant to proteolysis and suppression of efferocytosis by cleavage-inducing stimuli.	Proline	49-56	MER proto-oncogene tyrosine kinase	Mus musculus	70-75
21854076-0	2011	Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity.	Proline	18-25	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	85-117
21932236-2	2011	Excellent yields (up to 93%) and a significant improvement in diastereoselectivity (anti/syn up to 45:1) as well as enantioselectivity (up to more than 99% ee) compared with using proline as the sole catalyst were observed.	Proline	180-187	synemin	Homo sapiens	89-92
21854076-0	2011	Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity.	Proline	18-25	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	119-123
21854076-0	2011	Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity.	Proline	18-25	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	124-129
21854076-3	2011	We investigated whether prolines in or near the transmembrane helices are essential for BCRP function.	Proline	24-32	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	88-92
21854076-9	2011	These results strongly suggest Pro(392) and Pro(485) are important in determining the overall transport activity and substrate selectivity of BCRP, respectively.	Proline	31-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	142-146
21854076-9	2011	These results strongly suggest Pro(392) and Pro(485) are important in determining the overall transport activity and substrate selectivity of BCRP, respectively.	Proline	44-47	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	142-146
21854076-12	2011	Homology modeling indicates that Pro(392) may play an important role in the communication between the MSD and NBD as it is predicted to be located at the interface between the two functional domains, and Pro(485) induces flexible hinges that may be essential for the broad substrate specificity of BCRP.	Proline	33-36	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	298-302
21932236-4	2011	In situ chelation of CoCl(2) and proline (1:2) is proposed to promote the reaction through a six-membered Zimmermann-Traxler type transition state involving the positioning of proline-enamine and the aldehyde through chelation to Co(II).	Proline	33-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
21708174-0	2011	Structure of H/ACA RNP protein Nhp2p reveals cis/trans isomerization of a conserved proline at the RNA and Nop10 binding interface.	Proline	84-91	snoRNA-binding protein NHP2	Saccharomyces cerevisiae S288C	31-36
21873236-6	2011	Significant structural differences exist in the overall fold of MAL compared with other TIR domain structures: A sequence motif comprising a beta-strand in other TIR domains instead corresponds to a long loop, placing the functionally important "BB loop" proline motif in a unique surface position in MAL.	Proline	255-262	mal, T cell differentiation protein	Homo sapiens	64-67
21841133-9	2011	Our results demonstrate that Ly49i2 recognizes RT1-A1(c) bound with peptides that have Pro or Val at P2, whereas little or no recognition is observed when RT1-A1(c) is complexed with peptide bearing Gln at P2.	Proline	87-90	Ly49 inhibitory receptor 2	Rattus norvegicus	29-35
21776536-0	2011	L-Proline promoted fluorescent sensor for Mg2+ detection in a multicomponent sensory system.	Proline	0-9	mucin 7, secreted	Homo sapiens	42-45
21708174-0	2011	Structure of H/ACA RNP protein Nhp2p reveals cis/trans isomerization of a conserved proline at the RNA and Nop10 binding interface.	Proline	84-91	snoRNP complex protein NOP10	Saccharomyces cerevisiae S288C	107-112
21757687-7	2011	In RNA interference experiments, P3H2 protein synthesis was suppressed coordinately with prolyl 3-hydroxylation at Pro-944, Pro-707, and the C-terminal GPP repeat of the pNalpha1(II) chain, but Pro-986 remained fully hydroxylated.	Proline	115-118	prolyl 3-hydroxylase 2	Homo sapiens	33-37
21757687-7	2011	In RNA interference experiments, P3H2 protein synthesis was suppressed coordinately with prolyl 3-hydroxylation at Pro-944, Pro-707, and the C-terminal GPP repeat of the pNalpha1(II) chain, but Pro-986 remained fully hydroxylated.	Proline	124-127	prolyl 3-hydroxylase 2	Homo sapiens	33-37
21435071-12	2011	Genetic analysis revealed a nucleotide substitution in codon 47 in one allele of the PI12 gene, resulting in a proline for leucine amino acid substitution (L47P).	Proline	111-118	serpin family I member 1	Homo sapiens	85-89
21757687-7	2011	In RNA interference experiments, P3H2 protein synthesis was suppressed coordinately with prolyl 3-hydroxylation at Pro-944, Pro-707, and the C-terminal GPP repeat of the pNalpha1(II) chain, but Pro-986 remained fully hydroxylated.	Proline	124-127	prolyl 3-hydroxylase 2	Homo sapiens	33-37
21757687-8	2011	Furthermore, when P3H2 expression was turned off, as seen naturally in cultured SAOS-2 osteosarcoma cells, full 3Hyp occupancy at Pro-986 in alpha1(I) chains was unaffected, whereas 3-hydroxylation of residue Pro-944 in the alpha2(V) chain was largely lost, and 3-hydroxylation of Pro-707 in alpha2(V) and alpha2(I) chains were sharply reduced.	Proline	130-133	prolyl 3-hydroxylase 2	Homo sapiens	18-22
21757687-8	2011	Furthermore, when P3H2 expression was turned off, as seen naturally in cultured SAOS-2 osteosarcoma cells, full 3Hyp occupancy at Pro-986 in alpha1(I) chains was unaffected, whereas 3-hydroxylation of residue Pro-944 in the alpha2(V) chain was largely lost, and 3-hydroxylation of Pro-707 in alpha2(V) and alpha2(I) chains were sharply reduced.	Proline	209-212	prolyl 3-hydroxylase 2	Homo sapiens	18-22
21757687-8	2011	Furthermore, when P3H2 expression was turned off, as seen naturally in cultured SAOS-2 osteosarcoma cells, full 3Hyp occupancy at Pro-986 in alpha1(I) chains was unaffected, whereas 3-hydroxylation of residue Pro-944 in the alpha2(V) chain was largely lost, and 3-hydroxylation of Pro-707 in alpha2(V) and alpha2(I) chains were sharply reduced.	Proline	209-212	prolyl 3-hydroxylase 2	Homo sapiens	18-22
21586312-7	2011	The mutagenesis of His269 and Leu267 of AKR1B14 into the corresponding residues (Arg and Pro, respectively) of AKR1B7 resulted in low and pH-independent activation by bile acids.	Proline	89-92	aldo-keto reductase family 1, member B7	Rattus norvegicus	40-47
21586312-7	2011	The mutagenesis of His269 and Leu267 of AKR1B14 into the corresponding residues (Arg and Pro, respectively) of AKR1B7 resulted in low and pH-independent activation by bile acids.	Proline	89-92	aldo-keto reductase family 1, member B7	Rattus norvegicus	111-117
21501142-8	2011	Celastrol bound to a recombinant p47(phox) and disrupted the binding of the proline rich region of p22(phox) to the tandem SH3 domain of p47(phox) and NOXO1, the cytosolic subunits of NOX2 and NOX1, respectively.	Proline	76-83	calcineurin like EF-hand protein 1	Homo sapiens	99-102
21501142-8	2011	Celastrol bound to a recombinant p47(phox) and disrupted the binding of the proline rich region of p22(phox) to the tandem SH3 domain of p47(phox) and NOXO1, the cytosolic subunits of NOX2 and NOX1, respectively.	Proline	76-83	pleckstrin	Homo sapiens	103-107
21757700-3	2011	Here, through analysis of IRE1alpha mutants associated with human somatic cancers, we have identified a highly conserved proline residue at position 830 (Pro(830)) that is critical for its structural integrity and hence, the activation of both kinase and RNase domains.	Proline	121-128	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	26-35
21628446-4	2011	Chromatographic purification and structural analysis by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) revealed an Ang II-like octapeptide, angioprotectin, with the sequence Pro-Glu-Val-Tyr-Ile-His-Pro-Phe, which differs from Ang II in Pro1 and Glu2 instead of Asp1 and Arg2.	Proline	217-220	angiogenin	Homo sapiens	158-161
21344271-2	2011	In the HIF1A P582S gene polymorphism (C1772T; rs 11549465 C/T), a single nucleotide transition from C   T alters the codon sequence from the usual amino acid; proline (C-allele), to serine (T-allele).	Proline	159-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	7-12
21628446-4	2011	Chromatographic purification and structural analysis by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) revealed an Ang II-like octapeptide, angioprotectin, with the sequence Pro-Glu-Val-Tyr-Ile-His-Pro-Phe, which differs from Ang II in Pro1 and Glu2 instead of Asp1 and Arg2.	Proline	217-220	angiotensinogen	Homo sapiens	158-164
21628446-5	2011	Pro-Glu-Val-Tyr-Ile-His-Pro-Phe in angioprotectin is most likely generated enzymatically from Ang II.	Proline	0-3	angiotensinogen	Homo sapiens	94-100
21794028-2	2011	Here we showed the effect of the proline to arginine substitution of 3BP2 in which is the most common mutation in patients with cherubism (P418R) on B-cell receptor signaling.	Proline	33-40	SH3 domain binding protein 2	Homo sapiens	69-73
21810655-1	2011	Pin1 is a peptidyl prolyl cis-trans isomerase that only binds to and isomerizes phosphorylated serine/threonine-proline motifs, inducing conformational changes that alter target protein function and phosphorylation.	Proline	112-119	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
21503961-2	2011	The two closely related isoenzymes SHIP1 (or SHIP) and SHIP2 contain a N-terminal SH2 domain, a catalytic domain, potential PTB domain-binding sites (NPXY), and C-terminal proline-rich regions with consensus sites for SH3 domain interactions.	Proline	172-179	inositol polyphosphate-5-phosphatase D	Homo sapiens	35-40
21503961-2	2011	The two closely related isoenzymes SHIP1 (or SHIP) and SHIP2 contain a N-terminal SH2 domain, a catalytic domain, potential PTB domain-binding sites (NPXY), and C-terminal proline-rich regions with consensus sites for SH3 domain interactions.	Proline	172-179	inositol polyphosphate-5-phosphatase D	Homo sapiens	35-39
21503961-2	2011	The two closely related isoenzymes SHIP1 (or SHIP) and SHIP2 contain a N-terminal SH2 domain, a catalytic domain, potential PTB domain-binding sites (NPXY), and C-terminal proline-rich regions with consensus sites for SH3 domain interactions.	Proline	172-179	inositol polyphosphate phosphatase like 1	Homo sapiens	55-60
21947912-1	2011	The phosphorylation-specific peptidyl-prolyl isomerase Pin1 catalyzes the isomerization of the peptide bond preceding a proline residue between cis and trans isomers.	Proline	120-127	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	55-59
21947912-7	2011	Specific (13)C labeling at the Pin1-targeted proline residue provided multiple reporters sensitive to individual isomer binding and on-enzyme catalysis.	Proline	45-52	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	31-35
21919871-8	2011	Intraperitoneal administration of Proline-rich peptide, ((PRP), 1 mcg/100g weight of rats), originating from proteolysis of C-terminal glycoprotein a neurophysin II along with vasopressin and oxytocin and transferring from the hypothalamus to the neurohypophysis by axonal transport, initiates activation of the protein synthesis in all studied cellular subcomponents of brain cells.	Proline	34-41	proline rich protein 2-like 1	Rattus norvegicus	58-61
21919871-8	2011	Intraperitoneal administration of Proline-rich peptide, ((PRP), 1 mcg/100g weight of rats), originating from proteolysis of C-terminal glycoprotein a neurophysin II along with vasopressin and oxytocin and transferring from the hypothalamus to the neurohypophysis by axonal transport, initiates activation of the protein synthesis in all studied cellular subcomponents of brain cells.	Proline	34-41	arginine vasopressin	Rattus norvegicus	176-187
21538481-9	2011	The N-terminal sequences of the 14-kDa fragment were identified as Leu-Arg-Ala-Pro-Ser-Trp-Phe, indicating that this fragment is generated by cleavage at Phe54-Leu55 of alphaB-crystallin.	Proline	79-82	crystallin, alpha B	Rattus norvegicus	169-186
21708170-2	2011	In vitro experiments have shown that the proline-glutamic acid-valine-lysine (PEVK) rich element of titin interacts with actin, causing a viscous force in the sarcomere.	Proline	41-48	titin	Mus musculus	100-105
21715492-2	2011	Here, we report that the C-terminal proline-rich region (PRR) of ALIX folds back against the upstream domains and auto-inhibits V domain binding to viral late domains.	Proline	36-43	programmed cell death 6 interacting protein	Homo sapiens	65-69
21812053-2	2011	The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3-PIAS3 interaction.	Proline	14-21	protein inhibitor of activated STAT 3	Homo sapiens	87-92
21812053-2	2011	The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3-PIAS3 interaction.	Proline	14-21	signal transducer and activator of transcription 3	Homo sapiens	115-120
21812053-2	2011	The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3-PIAS3 interaction.	Proline	14-21	protein inhibitor of activated STAT 3	Homo sapiens	121-126
21481968-3	2011	Genes encoding proline dehydrogenase (PDH), the key enzyme in proline degradation, and the proline biosynthetic enzyme, Delta(1)-pyrroline-5-carboxylate synthetase (P5CS), play an important role in responses to osmotic and drought stresses.	Proline	15-22	delta-1-pyrroline-5-carboxylate synthase-like	Nicotiana tabacum	120-163
21481968-3	2011	Genes encoding proline dehydrogenase (PDH), the key enzyme in proline degradation, and the proline biosynthetic enzyme, Delta(1)-pyrroline-5-carboxylate synthetase (P5CS), play an important role in responses to osmotic and drought stresses.	Proline	62-69	delta-1-pyrroline-5-carboxylate synthase-like	Nicotiana tabacum	120-163
20443084-11	2011	Our data show that proline homozygosity at p53 codon 72 is associated with decreased breast cancer risk in Arab women.	Proline	19-26	tumor protein p53	Homo sapiens	43-46
21316118-4	2011	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in LC were 37.0%, 46.2%, and 16.7%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively (p&lt;0.01).	Proline	60-63	tumor protein p53	Homo sapiens	19-22
21316118-4	2011	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in LC were 37.0%, 46.2%, and 16.7%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively (p&lt;0.01).	Proline	69-72	tumor protein p53	Homo sapiens	19-22
21316118-4	2011	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in LC were 37.0%, 46.2%, and 16.7%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively (p&lt;0.01).	Proline	69-72	tumor protein p53	Homo sapiens	19-22
21751375-7	2011	Further studies aided by site-directed mutagenesis, immunoprecipitation and mammalian two-hybrid assay have concluded that the phosphorylation of a Proline-directed Ser92 residue modulates the selective binding ability of CBP with beta-catenin.	Proline	148-155	CREB binding protein	Homo sapiens	222-225
21575103-8	2011	In vitro, PKC-beta inhibition showed modest, dose-dependent reductions in mesangial cell (3) H-thymidine and (3) H-proline incorporations, indices of cell proliferation and collagen synthesis, respectively.	Proline	115-122	protein kinase C beta	Homo sapiens	10-18
21917546-3	2011	Stable isotope labeling experiments show that, after MeJA elicitation, Arg, Pro, and Glu are converted to Orn, which is acetylated by NATA1 to produce N(delta)-acetylornithine.	Proline	76-79	Acyl-CoA N-acyltransferases (NAT) superfamily protein	Arabidopsis thaliana	134-139
21795389-4	2011	MICAL-L1 has a calponin homology (CH), LIM, proline rich and coiled-coil domains.	Proline	44-51	MICAL like 1	Homo sapiens	0-8
21751375-7	2011	Further studies aided by site-directed mutagenesis, immunoprecipitation and mammalian two-hybrid assay have concluded that the phosphorylation of a Proline-directed Ser92 residue modulates the selective binding ability of CBP with beta-catenin.	Proline	148-155	catenin beta 1	Homo sapiens	231-243
21848462-7	2011	Homology-based structural modeling of human interleukin-36Ra suggests that the proline at position 27 affects both the stability of interleukin-36Ra and its interaction with its receptor, interleukin-1 receptor-like 2 (interleukin-1 receptor-related protein 2).	Proline	79-86	interleukin 1 receptor like 2	Homo sapiens	188-217
21299413-10	2011	Finally, we found that a PEST motif sequence (rich in proline, glutamine, serine, and threonine) from amino acid 47 to 72 located toward the N-terminus of NANOG was shown to target the protein for degradation.	Proline	54-61	Nanog homeobox	Homo sapiens	155-160
21756916-8	2011	Additionally, beta-tubulin peptide scan on microarrays demonstrates interaction of parvulin 17 with an Arg-Pro-Asp motif corresponding to proline residue 87 of beta-tubulin.	Proline	138-145	peptidylprolyl cis/trans isomerase, NIMA-interacting 4	Homo sapiens	83-94
21704044-5	2011	We present the crystal structure of a proline-to-alanine mutant Saccharomyces cerevisiae Cks protein (Cks1 P93A) that preferentially adopts the monomer conformation but surprisingly fails to bind Cdk.	Proline	38-45	cyclin-dependent protein kinase regulatory subunit CKS1	Saccharomyces cerevisiae S288C	102-106
21848462-7	2011	Homology-based structural modeling of human interleukin-36Ra suggests that the proline at position 27 affects both the stability of interleukin-36Ra and its interaction with its receptor, interleukin-1 receptor-like 2 (interleukin-1 receptor-related protein 2).	Proline	79-86	interleukin 1 receptor like 2	Homo sapiens	219-259
21721556-0	2011	Prolines in betaA-sheet of neural cadherin act as a switch to control the dynamics of the equilibrium between monomer and dimer.	Proline	0-8	cadherin 2	Homo sapiens	27-42
21771881-4	2011	To gain new insight into the CD9 tail, three C-terminal amino acids (Glu-Met-Val) were replaced with residues corresponding to C-terminal amino acids from tetraspanin protein CD82 (Pro-Lys-Tyr).	Proline	181-184	CD82 molecule	Homo sapiens	175-179
21843334-1	2011	BACKGROUND: Single-nucleotide polymorphisms within TP53 gene (codon 72 exon 4, rs1042522, encoding either arginine or proline) and MDM2 promoter (SNP309; rs2279744), have been independently associated with increased risk of several cancer types.	Proline	118-125	tumor protein p53	Homo sapiens	51-55
21701751-1	2011	A homochiral metal-organic triangle Co-Pro1 was achieved via self-assembly by incorporating a L-proline moiety within the corresponding ligand.	Proline	94-103	lamin A/C	Homo sapiens	39-43
21701751-2	2011	Co-Pro1 comprised L-proline moieties as asymmetric catalytic active sites and a helical-like cavity, it worked as an asymmetric catalyst to prompt aldol reactions with size-, stereo- and enantioselectivity.	Proline	18-27	lamin A/C	Homo sapiens	3-7
21683879-8	2011	The elevation of Pro levels promotes accumulation of ectopically expressed Cell Wall Linker Protein (AtCWLP), a membrane protein with an external Pro-rich domain.	Proline	17-20	cell wall-plasma membrane linker protein	Arabidopsis thaliana	101-107
21714498-1	2011	Pin1 is a prolyl isomerase that recognizes phosphorylated Ser/Thr-Pro sites, and phosphatase inhibitor-2 (I-2) is phosphorylated during mitosis at a PSpTP site that is expected to be a Pin1 substrate.	Proline	66-69	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
21565176-8	2011	Using these techniques we identified two splicing factor proteins, serine/arginine-rich splicing factor 3 (SRSF3) and splicing factor proline/glutamine-rich (SFPQ), that induced resistance to dFdC as well as other pyrimidine nucleoside analogs when their expression was decreased in HeLa cells.	Proline	134-141	splicing factor proline and glutamine rich	Homo sapiens	158-162
21461655-5	2011	RESULTS: The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes of the p53 codon 72 polymorphism were 43.3, 42.0, and 13.0% in the gastric cancer patients; 40.5, 45.0, and 14.0% in the colorectal cancer patients; and 43.2, 45.6, and 11.2% in the controls, respectively.	Proline	41-44	tumor protein p53	Homo sapiens	75-78
21438886-14	2011	Likewise, there were decreased amounts and/or phosphorylation levels of various mTORC1 and mTORC2 components including raptor, proline-rich Akt substrate 40 kDa, mSin1, Deptor, and GbetaL.	Proline	127-134	CREB regulated transcription coactivator 1	Mus musculus	80-86
21438886-14	2011	Likewise, there were decreased amounts and/or phosphorylation levels of various mTORC1 and mTORC2 components including raptor, proline-rich Akt substrate 40 kDa, mSin1, Deptor, and GbetaL.	Proline	127-134	CREB regulated transcription coactivator 2	Mus musculus	91-97
21438886-14	2011	Likewise, there were decreased amounts and/or phosphorylation levels of various mTORC1 and mTORC2 components including raptor, proline-rich Akt substrate 40 kDa, mSin1, Deptor, and GbetaL.	Proline	127-134	AKT serine/threonine kinase 1	Homo sapiens	140-143
21274613-1	2011	Human PRTB encodes a proline-rich protein of 168 amino acids (PRTB).	Proline	21-28	DAZ associated protein 2	Homo sapiens	6-10
21274613-1	2011	Human PRTB encodes a proline-rich protein of 168 amino acids (PRTB).	Proline	21-28	DAZ associated protein 2	Homo sapiens	62-66
21511531-5	2011	Recent studies demonstrated that the FKBP52 FK1 domain and the proline-rich loop within this domain are functionally important for FKBP52 regulation of receptor function.	Proline	63-70	FK506 binding protein 4	Mus musculus	131-137
21757996-1	2011	Proline dehydrogenase (ProDH) catalyzes the flavin-dependent oxidation of Pro into Delta1-pyrroline-5-carboxylate (P5C).	Proline	0-3	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	23-28
21786200-6	2011	With some exceptions, ALG-2-interacting proteins commonly contain Pro-rich regions, and ALG-2 recognizes at least two distinct Pro-containing motifs: PPYP(X)nYP (X, variable; n=4 in ALIX and PLSCR3) and PXPGF (represented by Sec31A).	Proline	66-69	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	22-27
21629912-7	2011	This study reveals that both the selenol or thiol moiety and proline residues are essential for ACE inhibition.	Proline	61-68	angiotensin I converting enzyme	Homo sapiens	96-99
21554509-5	2011	Both P473L mutation in the SH3 domain of Rvs167p and deletion of the proline-rich regions of Gyp5p and Gyl1p disrupt the interaction of Rvs167p with Gyp5p and Gyl1p and impair the localization of Rvs167p to the tips of small buds.	Proline	69-76	GTPase-activating protein GYP5	Saccharomyces cerevisiae S288C	93-98
21554509-5	2011	Both P473L mutation in the SH3 domain of Rvs167p and deletion of the proline-rich regions of Gyp5p and Gyl1p disrupt the interaction of Rvs167p with Gyp5p and Gyl1p and impair the localization of Rvs167p to the tips of small buds.	Proline	69-76	Gyl1p	Saccharomyces cerevisiae S288C	103-108
21554509-5	2011	Both P473L mutation in the SH3 domain of Rvs167p and deletion of the proline-rich regions of Gyp5p and Gyl1p disrupt the interaction of Rvs167p with Gyp5p and Gyl1p and impair the localization of Rvs167p to the tips of small buds.	Proline	69-76	amphiphysin	Saccharomyces cerevisiae S288C	136-143
21554509-5	2011	Both P473L mutation in the SH3 domain of Rvs167p and deletion of the proline-rich regions of Gyp5p and Gyl1p disrupt the interaction of Rvs167p with Gyp5p and Gyl1p and impair the localization of Rvs167p to the tips of small buds.	Proline	69-76	GTPase-activating protein GYP5	Saccharomyces cerevisiae S288C	149-154
21554509-5	2011	Both P473L mutation in the SH3 domain of Rvs167p and deletion of the proline-rich regions of Gyp5p and Gyl1p disrupt the interaction of Rvs167p with Gyp5p and Gyl1p and impair the localization of Rvs167p to the tips of small buds.	Proline	69-76	Gyl1p	Saccharomyces cerevisiae S288C	159-164
21554509-5	2011	Both P473L mutation in the SH3 domain of Rvs167p and deletion of the proline-rich regions of Gyp5p and Gyl1p disrupt the interaction of Rvs167p with Gyp5p and Gyl1p and impair the localization of Rvs167p to the tips of small buds.	Proline	69-76	amphiphysin	Saccharomyces cerevisiae S288C	136-143
21653319-4	2011	BCR-ABL1 SH3 domain interacts with RAD51 proline-rich regions, resulting in direct phosphorylation of RAD51 on Y315 (pY315).	Proline	41-48	BCR activator of RhoGEF and GTPase	Homo sapiens	0-8
21653319-4	2011	BCR-ABL1 SH3 domain interacts with RAD51 proline-rich regions, resulting in direct phosphorylation of RAD51 on Y315 (pY315).	Proline	41-48	RAD51 recombinase	Homo sapiens	35-40
21653319-4	2011	BCR-ABL1 SH3 domain interacts with RAD51 proline-rich regions, resulting in direct phosphorylation of RAD51 on Y315 (pY315).	Proline	41-48	RAD51 recombinase	Homo sapiens	102-107
21586576-4	2011	Mutation of the TSHR-specific alanine (Ala-5935 50) at this position to proline resulted in a 20-fold reduction of cell surface expression.	Proline	72-79	thyroid stimulating hormone receptor	Homo sapiens	16-20
21762808-0	2011	Mechanism of host cell MAPK/ERK-2 incorporation into lentivirus particles: characterization of the interaction between MAPK/ERK-2 and proline-rich-domain containing capsid region of structural protein Gag.	Proline	134-141	mitogen-activated protein kinase 1	Homo sapiens	124-129
21762808-8	2011	Utilizing virus-like particles directed by Gag, we have shown that the exchange of conserved proline residues within capsid of Gag(p55) resulted in impaired incorporation of MAPK/ERK-2.	Proline	93-100	phosphoinositide-3-kinase regulatory subunit 3	Homo sapiens	131-134
21762808-8	2011	Utilizing virus-like particles directed by Gag, we have shown that the exchange of conserved proline residues within capsid of Gag(p55) resulted in impaired incorporation of MAPK/ERK-2.	Proline	93-100	mitogen-activated protein kinase 1	Homo sapiens	179-184
21494810-3	2011	Our experimental data indicates that proline-rich polypeptide-1 (PRP-1, galarmin) is immunomodulator cytokine, produced by hypothalamic neurosecretory cells and exerts its antiproliferative effect on the tumor cells of mesenchymal origin via inhibiting mTOR kinase activity and repressing cell cycle progression.	Proline	37-44	mechanistic target of rapamycin kinase	Homo sapiens	253-257
21249361-2	2011	A number of single nucleotide polymorphisms (SNPs) of SSTR5 have been identified, including P335L, a nonsynonymous SNP located in the protein C-terminal region and encrypted by the codon CCG (proline) or the codon CTG (leucine).	Proline	192-199	somatostatin receptor 5	Homo sapiens	54-59
21249361-5	2011	Human SSTR5 leucine variant (L335) was generated by performing site-directed mutagenesis using SSTR5 proline variant (P335) as a template.	Proline	101-108	somatostatin receptor 5	Homo sapiens	6-11
21646353-4	2011	We demonstrate that the characteristic His/Met-rich segment Met(672)-Pro(707) (HM-loop) that connects the first two transmembrane segments of ATP7A is important for copper release.	Proline	69-72	ATPase copper transporting alpha	Homo sapiens	142-147
21746900-1	2011	Pin1 is a modular enzyme that accelerates the cis-trans isomerization of phosphorylated-Ser/Thr-Pro (pS/T-P) motifs found in numerous signaling proteins regulating cell growth and neuronal survival.	Proline	96-99	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
21566141-3	2011	Besides the pathogenic polyQ expansion, Htt also contains a proline-rich region (PRR) located exactly in the C terminus to the polyQ tract.	Proline	60-67	huntingtin	Homo sapiens	40-43
21689634-4	2011	However, one Japanese SCA15 family was found to have a Pro to Leu (P1059L) substitution in IP(3)R1.	Proline	55-58	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	22-27
21689634-4	2011	However, one Japanese SCA15 family was found to have a Pro to Leu (P1059L) substitution in IP(3)R1.	Proline	55-58	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	91-98
21566141-3	2011	Besides the pathogenic polyQ expansion, Htt also contains a proline-rich region (PRR) located exactly in the C terminus to the polyQ tract.	Proline	60-67	nuclear receptor subfamily 1 group I member 2	Homo sapiens	81-84
22210999-5	2011	A point mutation from G to C in exon 2 of ITGA2B causing a substitution of the expected amino acid arginine 72 (Arg(72)) by a proline (Pro(72)) was encountered.	Proline	126-133	integrin subunit alpha 2b	Equus caballus	42-48
21566136-6	2011	Exploiting a human single nucleotide polymorphism in the core domain of FGF12 (P149Q), we identified a surface proline that contributes a part of this pairwise specificity.	Proline	111-118	fibroblast growth factor 12	Homo sapiens	72-77
21566136-7	2011	This proline is conserved among all FHFs, and mutation of the homologous residue in FGF13 also leads to loss of interaction with a specific VGSC CT (Na(V)1.1) and loss of modulation of the resultant Na(+) channel function.	Proline	5-12	fibroblast growth factor 13	Homo sapiens	84-89
22210999-5	2011	A point mutation from G to C in exon 2 of ITGA2B causing a substitution of the expected amino acid arginine 72 (Arg(72)) by a proline (Pro(72)) was encountered.	Proline	135-138	integrin subunit alpha 2b	Equus caballus	42-48
21746772-0	2011	Inflammatory effects of blood leukocytes: association with vascular function in neuropeptide Y proline 7-genotyped type 2 diabetes patients.	Proline	95-102	neuropeptide Y	Homo sapiens	80-94
21402718-3	2011	By using human p53 knockin (Hupki) mice carrying a single nucleotide polymorphism (SNP) at codon 72 (arginine/proline), the arginine allele was demonstrated to produce higher uterine LIF levels during implantation than the proline allele.	Proline	110-117	tumor protein p53	Homo sapiens	15-18
21585399-3	2011	AAMs exert their activity in part via the enzyme arginase-1 (Arg1), which hydrolyses L-arginine into urea and ornithine, and can supply precursor substrate for proline and polyamine production.	Proline	160-167	arginase, liver	Mus musculus	61-65
21525241-5	2011	Of interest, cTAGE5, as well as TANGO1, is capable of interacting with the inner-layer coatomer of COPII Sec23/24 complex through their C-terminal proline-rich domains and required for collagen VII secretion.	Proline	147-154	MIA SH3 domain ER export factor 2	Homo sapiens	13-19
21525241-5	2011	Of interest, cTAGE5, as well as TANGO1, is capable of interacting with the inner-layer coatomer of COPII Sec23/24 complex through their C-terminal proline-rich domains and required for collagen VII secretion.	Proline	147-154	MIA SH3 domain ER export factor 3	Homo sapiens	32-38
21539473-1	2011	INTRODUCTION: Prolyl Oligopeptidase (POP) is a serine peptidase that cleaves post-proline bonds in short peptides.	Proline	82-89	prolyl endopeptidase	Homo sapiens	14-35
21539473-1	2011	INTRODUCTION: Prolyl Oligopeptidase (POP) is a serine peptidase that cleaves post-proline bonds in short peptides.	Proline	82-89	prolyl endopeptidase	Homo sapiens	37-40
21398368-6	2011	Here, we report a biophysical and structural characterization of the K58P-W60G beta2m mutant, where a Pro residue has been introduced in the type I beta-turn i + 1 position.	Proline	102-105	alpha-2-macroglobulin	Homo sapiens	79-85
21472811-8	2011	Furthermore, the IkappaBzeta-p50 homodimer complex, which lacks Pro, Glu (and Asp), Ser and Thr (PEST motif), facilitated gene expression.	Proline	64-67	NFKB inhibitor zeta	Homo sapiens	17-28
21472811-8	2011	Furthermore, the IkappaBzeta-p50 homodimer complex, which lacks Pro, Glu (and Asp), Ser and Thr (PEST motif), facilitated gene expression.	Proline	64-67	nuclear factor kappa B subunit 1	Homo sapiens	29-32
21627711-2	2011	In normoxia, PHD2 hydroxylates proline residues on HIF-1alpha, rendering it inactive.	Proline	31-38	egl-9 family hypoxia-inducible factor 1	Mus musculus	13-17
21627711-2	2011	In normoxia, PHD2 hydroxylates proline residues on HIF-1alpha, rendering it inactive.	Proline	31-38	hypoxia inducible factor 1, alpha subunit	Mus musculus	51-61
21702901-3	2011	RESULTS: A recombinant human collagen type I alpha-1 (rCIalpha1) with high percentage of hydroxylated prolines (Hyp) was produced in transgenic maize seeds when co-expressed with both the alpha- and beta- subunits of a recombinant human P4H (rP4H).	Proline	102-110	collagen type I alpha 1 chain	Homo sapiens	29-52
21504895-8	2011	Indeed, mutagenesis demonstrated that the CaMKKbeta residue Pro(274), which replaces the conserved acidic residue of other protein kinases, is an important determinant for the selective inhibition by STO-609.	Proline	60-63	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	42-51
21508312-4	2011	Moreover, RhoU physically associates with activated EGFR in a GRB2-dependent manner through specific proline-rich motifs within its N-terminus.	Proline	101-108	epidermal growth factor receptor	Homo sapiens	52-56
21682951-2	2011	Pin1 (peptidyl-prolyl cis-trans isomerase) is the only enzyme known that can isomerise specific Ser/Thr-Pro peptide bonds after phosphorylation and regulate their conformational changes with high efficiency.	Proline	104-107	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
21620802-1	2011	Prolyl oligopeptidase (POP) is a post-proline cleaving enzyme, which is widely distributed in various organs, with high levels in the brain.	Proline	38-45	prolyl endopeptidase	Homo sapiens	0-21
21620802-1	2011	Prolyl oligopeptidase (POP) is a post-proline cleaving enzyme, which is widely distributed in various organs, with high levels in the brain.	Proline	38-45	prolyl endopeptidase	Homo sapiens	23-26
21508312-4	2011	Moreover, RhoU physically associates with activated EGFR in a GRB2-dependent manner through specific proline-rich motifs within its N-terminus.	Proline	101-108	ras homolog family member U	Homo sapiens	10-14
21441247-5	2011	The majority of these SYN1 mutations were clustered in the proline-rich D-domain which is substrate of multiple protein kinases.	Proline	59-66	synapsin I	Homo sapiens	22-26
21508312-4	2011	Moreover, RhoU physically associates with activated EGFR in a GRB2-dependent manner through specific proline-rich motifs within its N-terminus.	Proline	101-108	growth factor receptor bound protein 2	Homo sapiens	62-66
21508312-5	2011	Mutation of these proline-rich sequences or suppression of GRB2 by RNA interference abrogates the interaction of RhoU with activated EGFR, as well as EGF-stimulated RhoU GTP binding.	Proline	18-25	ras homolog family member U	Homo sapiens	113-117
21508312-5	2011	Mutation of these proline-rich sequences or suppression of GRB2 by RNA interference abrogates the interaction of RhoU with activated EGFR, as well as EGF-stimulated RhoU GTP binding.	Proline	18-25	epidermal growth factor receptor	Homo sapiens	133-137
21489990-1	2011	In the normal brain, tau protein is phosphorylated at a number of proline- and non-proline directed sites, which reduce tau microtubule binding and thus regulate microtubule dynamics.	Proline	66-73	microtubule associated protein tau	Homo sapiens	21-24
21489990-1	2011	In the normal brain, tau protein is phosphorylated at a number of proline- and non-proline directed sites, which reduce tau microtubule binding and thus regulate microtubule dynamics.	Proline	66-73	microtubule associated protein tau	Homo sapiens	120-123
21518755-4	2011	The chz mutation was mapped to the Ala-Asn-Pro tripeptide insertion into the junction region between the fifth and the sixth Ig-like domains of PTK7.	Proline	43-46	protein tyrosine kinase 7 (inactive)	Homo sapiens	144-148
21489990-1	2011	In the normal brain, tau protein is phosphorylated at a number of proline- and non-proline directed sites, which reduce tau microtubule binding and thus regulate microtubule dynamics.	Proline	83-90	microtubule associated protein tau	Homo sapiens	21-24
21489990-1	2011	In the normal brain, tau protein is phosphorylated at a number of proline- and non-proline directed sites, which reduce tau microtubule binding and thus regulate microtubule dynamics.	Proline	83-90	microtubule associated protein tau	Homo sapiens	120-123
21489990-5	2011	In this study, we found that lentivirus-mediated overexpression of Egr-1 in rat brain hippocampus and primary neurons in culture activates proline-directed kinase Cdk5, inactivates PP1, promotes tau phosphorylation at both proline-directed Ser(396/404) and non-proline-directed Ser(262) sites, and destabilizes microtubules.	Proline	139-146	early growth response 1	Rattus norvegicus	67-72
21521685-3	2011	HSP70 interacts strongly with the N-terminal activation domain of ATF5, which is expected to be rigid and uniquely structured under physiological conditions because of extraordinary high concentration (over 25%) of proline residues.	Proline	215-222	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
21521685-3	2011	HSP70 interacts strongly with the N-terminal activation domain of ATF5, which is expected to be rigid and uniquely structured under physiological conditions because of extraordinary high concentration (over 25%) of proline residues.	Proline	215-222	activating transcription factor 5	Homo sapiens	66-70
21489990-5	2011	In this study, we found that lentivirus-mediated overexpression of Egr-1 in rat brain hippocampus and primary neurons in culture activates proline-directed kinase Cdk5, inactivates PP1, promotes tau phosphorylation at both proline-directed Ser(396/404) and non-proline-directed Ser(262) sites, and destabilizes microtubules.	Proline	139-146	cyclin-dependent kinase 5	Rattus norvegicus	163-167
21489990-5	2011	In this study, we found that lentivirus-mediated overexpression of Egr-1 in rat brain hippocampus and primary neurons in culture activates proline-directed kinase Cdk5, inactivates PP1, promotes tau phosphorylation at both proline-directed Ser(396/404) and non-proline-directed Ser(262) sites, and destabilizes microtubules.	Proline	223-230	early growth response 1	Rattus norvegicus	67-72
21489990-5	2011	In this study, we found that lentivirus-mediated overexpression of Egr-1 in rat brain hippocampus and primary neurons in culture activates proline-directed kinase Cdk5, inactivates PP1, promotes tau phosphorylation at both proline-directed Ser(396/404) and non-proline-directed Ser(262) sites, and destabilizes microtubules.	Proline	223-230	early growth response 1	Rattus norvegicus	67-72
21489990-6	2011	Furthermore, in Egr-1(-/-) mouse brain, Cdk5 activity was decreased, PP1 activity was increased, and tau phosphorylation was reduced at both proline-directed and non-proline-directed sites.	Proline	141-148	early growth response 1	Mus musculus	16-21
21489990-6	2011	Furthermore, in Egr-1(-/-) mouse brain, Cdk5 activity was decreased, PP1 activity was increased, and tau phosphorylation was reduced at both proline-directed and non-proline-directed sites.	Proline	141-148	microtubule associated protein tau	Homo sapiens	101-104
21489990-6	2011	Furthermore, in Egr-1(-/-) mouse brain, Cdk5 activity was decreased, PP1 activity was increased, and tau phosphorylation was reduced at both proline-directed and non-proline-directed sites.	Proline	166-173	early growth response 1	Mus musculus	16-21
21489990-6	2011	Furthermore, in Egr-1(-/-) mouse brain, Cdk5 activity was decreased, PP1 activity was increased, and tau phosphorylation was reduced at both proline-directed and non-proline-directed sites.	Proline	166-173	microtubule associated protein tau	Homo sapiens	101-104
21476495-1	2011	Macrocyclic analogues of angiotensin IV (Ang IV, Val(1)-Tyr(2)-Ile(3)-His(4)-Pro(5)-Phe(6)) targeting the insulin-regulated aminopeptidase (IRAP) have been designed, synthesized, and evaluated biologically.	Proline	77-80	leucyl and cystinyl aminopeptidase	Homo sapiens	106-138
21489990-8	2011	When Cdk5 was inhibited, tau phosphorylation at both proline- and non-proline directed sites and PP1 phosphorylation were blocked, indicating that Egr-1 acts through Cdk5.	Proline	53-60	cyclin-dependent kinase 5	Rattus norvegicus	5-9
21489990-8	2011	When Cdk5 was inhibited, tau phosphorylation at both proline- and non-proline directed sites and PP1 phosphorylation were blocked, indicating that Egr-1 acts through Cdk5.	Proline	53-60	microtubule associated protein tau	Homo sapiens	25-28
21489990-8	2011	When Cdk5 was inhibited, tau phosphorylation at both proline- and non-proline directed sites and PP1 phosphorylation were blocked, indicating that Egr-1 acts through Cdk5.	Proline	53-60	early growth response 1	Rattus norvegicus	147-152
21489990-8	2011	When Cdk5 was inhibited, tau phosphorylation at both proline- and non-proline directed sites and PP1 phosphorylation were blocked, indicating that Egr-1 acts through Cdk5.	Proline	70-77	cyclin-dependent kinase 5	Rattus norvegicus	5-9
21659604-4	2011	We found that the phosphorylation response to insulin is largely mTOR dependent and that mTOR exhibits a unique preference for proline, hydrophobic, and aromatic residues at the +1 position.	Proline	127-134	insulin	Homo sapiens	46-53
21659604-4	2011	We found that the phosphorylation response to insulin is largely mTOR dependent and that mTOR exhibits a unique preference for proline, hydrophobic, and aromatic residues at the +1 position.	Proline	127-134	mechanistic target of rapamycin kinase	Homo sapiens	89-93
21489990-8	2011	When Cdk5 was inhibited, tau phosphorylation at both proline- and non-proline directed sites and PP1 phosphorylation were blocked, indicating that Egr-1 acts through Cdk5.	Proline	70-77	microtubule associated protein tau	Homo sapiens	25-28
21489990-8	2011	When Cdk5 was inhibited, tau phosphorylation at both proline- and non-proline directed sites and PP1 phosphorylation were blocked, indicating that Egr-1 acts through Cdk5.	Proline	70-77	early growth response 1	Rattus norvegicus	147-152
21652557-1	2011	The mitogen-activated protein kinase (MAPK) family includes the p38 kinases, which consist of highly conserved proline-directed serine-threonine protein kinases that are activated in response to inflammatory signals.	Proline	111-118	mitogen-activated protein kinase 14	Homo sapiens	64-67
21460222-2	2011	A bioinformatic search revealed several potential novel TRAPs, including a highly conserved protein, proline rich 7 (PRR7), previously described as a component of the PSD-95/N-methyl-d-aspartate receptor protein complex in postsynaptic densities (PSD) of rat neurons.	Proline	101-108	proline rich 7 (synaptic)	Rattus norvegicus	117-121
21460222-2	2011	A bioinformatic search revealed several potential novel TRAPs, including a highly conserved protein, proline rich 7 (PRR7), previously described as a component of the PSD-95/N-methyl-d-aspartate receptor protein complex in postsynaptic densities (PSD) of rat neurons.	Proline	101-108	discs large MAGUK scaffold protein 4	Rattus norvegicus	167-173
21346154-0	2011	The amino acid transporter SNAT2 mediates L-proline-induced differentiation of ES cells.	Proline	42-51	solute carrier family 38 member 2	Homo sapiens	27-32
21346154-5	2011	SNAT2 uptake of l-proline can be inhibited by the addition of millimolar concentrations of other substrates.	Proline	16-25	solute carrier family 38 member 2	Homo sapiens	0-5
21346154-7	2011	The ability of SNAT2 substrates, but not other amino acids, to prevent changes in morphology, gene expression, and differentiation kinetics suggested that l-proline uptake through SNAT2 was required for ES cell differentiation.	Proline	155-164	solute carrier family 38 member 2	Homo sapiens	15-20
21346154-7	2011	The ability of SNAT2 substrates, but not other amino acids, to prevent changes in morphology, gene expression, and differentiation kinetics suggested that l-proline uptake through SNAT2 was required for ES cell differentiation.	Proline	155-164	solute carrier family 38 member 2	Homo sapiens	180-185
21410436-7	2011	Using LC-MS/MS (liquid chromatography-tandem MS) detection, we show that all three PHD isoenzymes have a strong preference for hydroxylation of the CODDD proline residue over the NODDD proline residue and the preference is observed for both HIF1alpha and HIF2alpha protein substrates.	Proline	154-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	241-250
21410436-7	2011	Using LC-MS/MS (liquid chromatography-tandem MS) detection, we show that all three PHD isoenzymes have a strong preference for hydroxylation of the CODDD proline residue over the NODDD proline residue and the preference is observed for both HIF1alpha and HIF2alpha protein substrates.	Proline	154-161	endothelial PAS domain protein 1	Homo sapiens	255-264
21487760-0	2011	Defect in proline synthesis: pyrroline-5-carboxylate reductase 1 deficiency leads to a complex clinical phenotype with collagen and elastin abnormalities.	Proline	10-17	elastin	Homo sapiens	132-139
21435060-5	2011	Mutations of Cys 38 and Pro 39 residues affected the catalytic efficiency of enzymes, indicating that the presence of Cys 38 and Pro 39 residues is important for bmGSTO activity.	Proline	24-27	glutathione S-transferase omega 2	Bombyx mori	162-168
21435060-5	2011	Mutations of Cys 38 and Pro 39 residues affected the catalytic efficiency of enzymes, indicating that the presence of Cys 38 and Pro 39 residues is important for bmGSTO activity.	Proline	129-132	glutathione S-transferase omega 2	Bombyx mori	162-168
21487760-1	2011	Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the last step in proline synthesis.	Proline	71-78	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-35
21487760-1	2011	Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the last step in proline synthesis.	Proline	71-78	pyrroline-5-carboxylate reductase 1	Homo sapiens	37-42
21510665-2	2011	Previously, we had determined the specificity toward the residue before the proline for cyclophilin-, FKBP-, and parvulin-type prolyl isomerases by using proline-containing oligopeptides and refolding proteins as model substrates.	Proline	76-83	peptidylprolyl isomerase C	Homo sapiens	113-121
21486681-2	2011	Four mammalian NUMB isoforms have been identified, which utilize the phosphotyrosine binding (PTB) domain and the proline rich region (PRR) domain to regulate cell growth and differentiation in the developing nervous system.	Proline	114-121	NUMB endocytic adaptor protein	Homo sapiens	15-19
21510665-2	2011	Previously, we had determined the specificity toward the residue before the proline for cyclophilin-, FKBP-, and parvulin-type prolyl isomerases by using proline-containing oligopeptides and refolding proteins as model substrates.	Proline	154-161	peptidylprolyl isomerase C	Homo sapiens	113-121
21510665-4	2011	Human cyclophilin 18 and parvulin 10 from Escherichia coli show high activity, but low specificity, with respect to the residue following the proline.	Proline	142-149	peptidylprolyl isomerase C	Homo sapiens	25-33
21620138-6	2011	Mass spectrometry and anti-hydroxyproline antibody assays demonstrate PKM2 hydroxylation on proline-403/408.	Proline	34-41	pyruvate kinase M1/2	Homo sapiens	70-74
21160496-6	2011	We speculate that amino-acid substitutions causing larger, more disruptive changes to the K16 protein structure, such as a change in amino-acid charge in the p.Asn125Asp mutation or a bulky proline substitution in the p.Arg127Pro mutation, may also lead to more severe disease phenotypes.	Proline	190-197	keratin 16	Homo sapiens	90-93
21454683-1	2011	The common polymorphism of p53 at codon 72, either encoding proline or arginine, has drawn attention as a genetic factor associated with clinical outcome or cancer risk for the last 2 decades.	Proline	60-67	tumor protein p53	Homo sapiens	27-30
21222622-1	2011	Prolyl oligopeptidase (POP) is a serine protease that cleaves peptides shorter than 30-mer at the carboxyl side of an internal proline.	Proline	127-134	prolyl endopeptidase	Homo sapiens	0-21
21222622-1	2011	Prolyl oligopeptidase (POP) is a serine protease that cleaves peptides shorter than 30-mer at the carboxyl side of an internal proline.	Proline	127-134	prolyl endopeptidase	Homo sapiens	23-26
21446907-3	2011	MMP-9 enzyme recognizes a peptide sequence Lys-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys and cleaves the peptide into two parts.	Proline	51-54	matrix metallopeptidase 9	Homo sapiens	0-5
21277899-7	2011	Both proline (P(208)YAP(211)P(212)) and tyrosine residues (Y(206)QPY(209)APP) within the C-terminal proline-rich motif of CD28 are involved in the recruitment of FLNa/NIK complexes to the membrane as well as in the activation of NIK and IKKalpha.	Proline	5-12	CD28 molecule	Homo sapiens	122-126
21277899-7	2011	Both proline (P(208)YAP(211)P(212)) and tyrosine residues (Y(206)QPY(209)APP) within the C-terminal proline-rich motif of CD28 are involved in the recruitment of FLNa/NIK complexes to the membrane as well as in the activation of NIK and IKKalpha.	Proline	5-12	filamin A	Homo sapiens	162-166
21277899-7	2011	Both proline (P(208)YAP(211)P(212)) and tyrosine residues (Y(206)QPY(209)APP) within the C-terminal proline-rich motif of CD28 are involved in the recruitment of FLNa/NIK complexes to the membrane as well as in the activation of NIK and IKKalpha.	Proline	5-12	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	167-170
21277899-7	2011	Both proline (P(208)YAP(211)P(212)) and tyrosine residues (Y(206)QPY(209)APP) within the C-terminal proline-rich motif of CD28 are involved in the recruitment of FLNa/NIK complexes to the membrane as well as in the activation of NIK and IKKalpha.	Proline	5-12	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	229-232
21277899-7	2011	Both proline (P(208)YAP(211)P(212)) and tyrosine residues (Y(206)QPY(209)APP) within the C-terminal proline-rich motif of CD28 are involved in the recruitment of FLNa/NIK complexes to the membrane as well as in the activation of NIK and IKKalpha.	Proline	5-12	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	237-245
21277899-7	2011	Both proline (P(208)YAP(211)P(212)) and tyrosine residues (Y(206)QPY(209)APP) within the C-terminal proline-rich motif of CD28 are involved in the recruitment of FLNa/NIK complexes to the membrane as well as in the activation of NIK and IKKalpha.	Proline	100-107	CD28 molecule	Homo sapiens	122-126
21277899-7	2011	Both proline (P(208)YAP(211)P(212)) and tyrosine residues (Y(206)QPY(209)APP) within the C-terminal proline-rich motif of CD28 are involved in the recruitment of FLNa/NIK complexes to the membrane as well as in the activation of NIK and IKKalpha.	Proline	100-107	filamin A	Homo sapiens	162-166
21277899-7	2011	Both proline (P(208)YAP(211)P(212)) and tyrosine residues (Y(206)QPY(209)APP) within the C-terminal proline-rich motif of CD28 are involved in the recruitment of FLNa/NIK complexes to the membrane as well as in the activation of NIK and IKKalpha.	Proline	100-107	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	167-170
21277899-7	2011	Both proline (P(208)YAP(211)P(212)) and tyrosine residues (Y(206)QPY(209)APP) within the C-terminal proline-rich motif of CD28 are involved in the recruitment of FLNa/NIK complexes to the membrane as well as in the activation of NIK and IKKalpha.	Proline	100-107	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	229-232
21277899-7	2011	Both proline (P(208)YAP(211)P(212)) and tyrosine residues (Y(206)QPY(209)APP) within the C-terminal proline-rich motif of CD28 are involved in the recruitment of FLNa/NIK complexes to the membrane as well as in the activation of NIK and IKKalpha.	Proline	100-107	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	237-245
21168532-0	2011	Drosophila delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) is required for proline breakdown and mitochondrial integrity-Establishing a fly model for human type II hyperprolinemia.	Proline	81-88	delta-1-Pyrroline-5-carboxylate dehydrogenase 1	Drosophila melanogaster	11-56
21168532-0	2011	Drosophila delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) is required for proline breakdown and mitochondrial integrity-Establishing a fly model for human type II hyperprolinemia.	Proline	81-88	delta-1-Pyrroline-5-carboxylate dehydrogenase 1	Drosophila melanogaster	58-63
21168532-1	2011	Delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) is a nuclear-encoded mitochondrial enzyme that catalyzes the second step in proline degradation.	Proline	130-137	delta-1-Pyrroline-5-carboxylate dehydrogenase 1	Drosophila melanogaster	0-45
21168532-1	2011	Delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) is a nuclear-encoded mitochondrial enzyme that catalyzes the second step in proline degradation.	Proline	130-137	delta-1-Pyrroline-5-carboxylate dehydrogenase 1	Drosophila melanogaster	47-52
21168532-2	2011	Mutations in human P5CDh cause type II hyperprolinemia, a complex syndrome displaying increased serum proline and mental disabilities.	Proline	44-51	aldehyde dehydrogenase 4 family member A1	Homo sapiens	19-24
21213045-0	2011	Proline rich polypeptide (PRP-1) increases the superoxide-producing and ferrihemoglobin reducing activities of cytochrome B(558) isoforms from human lymphosarcoma tissue cells.	Proline	0-7	mitochondrially encoded cytochrome b	Homo sapiens	111-123
21243426-1	2011	This study aimed to further elucidate the molecular mechanisms of antiproliferative action of proline rich polypeptide 1 (PRP-1) cytokine, produced by neurosecretory cells of the hypothalamus to be considered as alternative adjuvant therapy for metastatic chondrosarcoma, which does not respond to chemotherapy or radiation and currently without any effective treatment.	Proline	94-101	prion protein	Homo sapiens	122-125
21454683-3	2011	The arginine form (p53-72R) shows significantly enhanced phosphorylation at Ser-6 and Ser-20 compared with the proline form (p53-72P).	Proline	111-118	tumor protein p53	Homo sapiens	19-22
21446695-7	2011	As a result of the increased size of CIN85 SH3 domain C, the proximal proline rich region is positioned such that a possible intramolecular interaction is structurally inhibited.	Proline	70-77	SH3 domain containing kinase binding protein 1	Homo sapiens	37-42
20931344-1	2011	The objective of this study was to determine developmental changes in mRNA and protein levels for N-acetylglutamate synthase (NAGS; a key enzyme in synthesis of citrulline and arginine from glutamine/glutamate and proline) in the small intestine of suckling piglets.	Proline	214-221	N-acetylglutamate synthase	Sus scrofa	98-124
20931344-1	2011	The objective of this study was to determine developmental changes in mRNA and protein levels for N-acetylglutamate synthase (NAGS; a key enzyme in synthesis of citrulline and arginine from glutamine/glutamate and proline) in the small intestine of suckling piglets.	Proline	214-221	N-acetylglutamate synthase	Sus scrofa	126-130
21514440-0	2011	Tyrosine nitration within the proline-rich region of Tau in Alzheimer"s disease.	Proline	30-37	microtubule associated protein tau	Homo sapiens	53-56
21514440-9	2011	However, nitration at Y197 was also identified in soluble tau from all control samples, including those at Braak stage 0, suggesting that nitration at this site in the proline-rich region of tau may have normal biological functions in the human brain.	Proline	168-175	microtubule associated protein tau	Homo sapiens	191-194
21222626-1	2011	Prolyl oligopeptidase or prolyl endopeptidase (PREP; EC 3.4.21.26) is an atypical serine protease that hydrolyses peptides and peptide hormones after proline in peptides up to around 30 residues long.	Proline	150-157	prolyl endopeptidase	Homo sapiens	0-21
21222626-1	2011	Prolyl oligopeptidase or prolyl endopeptidase (PREP; EC 3.4.21.26) is an atypical serine protease that hydrolyses peptides and peptide hormones after proline in peptides up to around 30 residues long.	Proline	150-157	prolyl endopeptidase	Homo sapiens	25-45
21222626-1	2011	Prolyl oligopeptidase or prolyl endopeptidase (PREP; EC 3.4.21.26) is an atypical serine protease that hydrolyses peptides and peptide hormones after proline in peptides up to around 30 residues long.	Proline	150-157	prolyl endopeptidase	Homo sapiens	47-51
21222628-2	2011	3.4.21.26, PREP) also known as prolyl oligopeptidase is an enzyme which cleaves several peptides at the carboxyl side of proline residues.	Proline	121-128	prolyl endopeptidase	Homo sapiens	11-15
21222628-2	2011	3.4.21.26, PREP) also known as prolyl oligopeptidase is an enzyme which cleaves several peptides at the carboxyl side of proline residues.	Proline	121-128	prolyl endopeptidase	Homo sapiens	31-52
21222629-1	2011	Prolyl oligopeptidase (POP), is an 80-kDa serine protease that hydrolyzes peptides smaller than 30-mer at the carboxyl side of an internal proline-residue.	Proline	139-146	prolyl endopeptidase	Homo sapiens	0-21
21222629-1	2011	Prolyl oligopeptidase (POP), is an 80-kDa serine protease that hydrolyzes peptides smaller than 30-mer at the carboxyl side of an internal proline-residue.	Proline	139-146	prolyl endopeptidase	Homo sapiens	23-26
21353493-1	2011	Although the designer proline-rich antimicrobial peptide A3-APO has only modest activity against Escherichia coli and Acinetobacter baumannii in vitro, in mouse models of systemic and wound infections it shows superior efficacy compared with conventional antibiotics.	Proline	22-29	anterior polar opacity	Mus musculus	60-63
21544207-11	2011	The third pathway corresponds to parallel evolution of several sub-families in relation with a covarion process involving proline residues in TM2 and TM5.	Proline	122-129	tropomyosin 3	Homo sapiens	150-153
21559412-5	2011	We identified a new highly conserved cluster of proline-rich motifs on the bestrophin-1 C-terminus between amino acid position 468 and 486, which enables possible binding to SH3-domains of beta-subunits.	Proline	48-55	bestrophin 1	Homo sapiens	75-87
21559412-6	2011	A bestrophin-1 that lacks these proline-rich motifs (DeltaCT-PxxP bestrophin-1) showed reduced efficiency to co-immunoprecipitate with beta3 and beta4-subunits.	Proline	32-39	bestrophin 1	Homo sapiens	2-14
21559412-6	2011	A bestrophin-1 that lacks these proline-rich motifs (DeltaCT-PxxP bestrophin-1) showed reduced efficiency to co-immunoprecipitate with beta3 and beta4-subunits.	Proline	32-39	bestrophin 1	Homo sapiens	66-78
21559412-10	2011	In summary, we described new proline-rich motifs on bestrophin-1 C-terminus, which help to maintain the ability of beta-subunits to regulate surface expression of pore-forming Ca(V) Ca(2+)-channel subunits.	Proline	29-36	bestrophin 1	Homo sapiens	52-64
21552497-6	2011	Mutational analysis of the CRYGD identified a C A transversion at nucleotide position c.70 in exon 2, which resulted in a threonine substitution for proline at amino-acid residue 24 (P24T).	Proline	149-156	crystallin gamma D	Homo sapiens	27-32
21145377-1	2011	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is ubiquitous in the nervous system and interacts with a myriad of substrates.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
21145377-1	2011	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is ubiquitous in the nervous system and interacts with a myriad of substrates.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
21421858-3	2011	In this study, we examined whether the nuclear receptor coregulator PELP1 (proline-, glutamic acid-, leucine-rich protein-1) contributes to progression and metastatic potential of ovarian cancer cells and determined whether blocking of the PELP1 signaling axis had a therapeutic effect.	Proline	75-82	proline, glutamate and leucine rich protein 1	Homo sapiens	68-73
21389092-0	2011	Deletion of the proline-rich region of the murine metastasis susceptibility gene Brd4 promotes epithelial-to-mesenchymal transition- and stem cell-like conversion.	Proline	16-23	bromodomain containing 4	Mus musculus	81-85
21335549-8	2011	Hydroxylation at the three sites in endogenous human HIF-1alpha proteins was suppressed by hypoxia in the order Pro(402) &gt; Pro(564) &gt; Asn(803).	Proline	112-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63
21370851-2	2011	The previously determined crystal structure of cis-CaaD and its promiscuous phenylpyruvate tautomerase (PPT) activity link this dehalogenase to the tautomerase superfamily, a group of homologous proteins that are characterized by a catalytic amino-terminal proline and a beta-alpha-beta structural fold.	Proline	257-264	macrophage migration inhibitory factor	Homo sapiens	76-102
21296884-6	2011	We showed that glycine 22 and proline 27 in hydrophobic domain 1 of Pen-2 are essential for complex formation and stability of gamma-secretase.	Proline	30-37	presenilin enhancer, gamma-secretase subunit	Homo sapiens	68-73
21472842-6	2011	RESULTS: The dark-like mutation causes cardiomyocyte hypertrophy due to loss-of-function of peptidase d (Pepd), which encodes prolidase, a cytosolic enzyme that recycles proline for collagen re-synthesis.	Proline	170-177	peptidase D	Mus musculus	92-103
21472004-3	2011	In addition to the BAG domain, BAG3 contains also a WW domain and a proline-rich (PXXP) repeat, that mediate binding to partners different from Hsp70.	Proline	68-75	BAG cochaperone 3	Homo sapiens	31-35
21472842-6	2011	RESULTS: The dark-like mutation causes cardiomyocyte hypertrophy due to loss-of-function of peptidase d (Pepd), which encodes prolidase, a cytosolic enzyme that recycles proline for collagen re-synthesis.	Proline	170-177	peptidase D	Mus musculus	105-109
21472842-6	2011	RESULTS: The dark-like mutation causes cardiomyocyte hypertrophy due to loss-of-function of peptidase d (Pepd), which encodes prolidase, a cytosolic enzyme that recycles proline for collagen re-synthesis.	Proline	170-177	peptidase D	Mus musculus	126-135
21300751-6	2011	In contrast, Akt activity, as assessed by Akt phosphorylation status (T308 and S473), phosphorylation of direct downstream targets (glycogen synthase kinase 3 beta, proline-rich Akt substrate 40 kDa and tuberous sclerosis 2 (TSC2)) and a kinase assay, was not significantly increased until 2-3 days of overload.	Proline	165-172	AKT serine/threonine kinase 1	Homo sapiens	13-16
21314817-3	2011	FAP possesses a rare catalytic activity, hydrolysis of the post-proline bond two or more residues from the N-terminus of target substrates.	Proline	64-71	fibroblast activation protein alpha	Homo sapiens	0-3
21212097-10	2011	This mutation causes a substitution of a leucine for a highly conserved proline at amino acid 182 in TECR (trans-2,3-enoyl-CoA reductase), a synaptic glycoprotein.	Proline	72-79	trans-2,3-enoyl-CoA reductase	Homo sapiens	101-105
21212097-10	2011	This mutation causes a substitution of a leucine for a highly conserved proline at amino acid 182 in TECR (trans-2,3-enoyl-CoA reductase), a synaptic glycoprotein.	Proline	72-79	trans-2,3-enoyl-CoA reductase	Homo sapiens	107-136
21277926-4	2011	This study further investigates the role of proline in BF2"s antimicrobial mechanism by considering the effect of changing proline position on membrane translocation, membrane permeabilization, and antimicrobial activity.	Proline	44-51	forkhead box G1	Homo sapiens	55-58
21307025-4	2011	Unlike EpiSCs, l-Pro-induced cells (PiCs) contribute to chimeric embryos and rely on leukemia inhibitor factor (LIF) to self-renew.	Proline	15-20	leukemia inhibitory factor	Mus musculus	85-110
21307025-4	2011	Unlike EpiSCs, l-Pro-induced cells (PiCs) contribute to chimeric embryos and rely on leukemia inhibitor factor (LIF) to self-renew.	Proline	15-20	leukemia inhibitory factor	Mus musculus	112-115
20308993-4	2011	Sequencing of the genes within the deletion identified a paternally inherited nonsynonymous amino-acid substitution at position 614 of diaphanous homolog 3 (DIAPH3) (proline to threonine; Pro614Thr).	Proline	166-173	diaphanous related formin 3	Homo sapiens	135-155
20308993-4	2011	Sequencing of the genes within the deletion identified a paternally inherited nonsynonymous amino-acid substitution at position 614 of diaphanous homolog 3 (DIAPH3) (proline to threonine; Pro614Thr).	Proline	166-173	diaphanous related formin 3	Homo sapiens	157-163
21277926-4	2011	This study further investigates the role of proline in BF2"s antimicrobial mechanism by considering the effect of changing proline position on membrane translocation, membrane permeabilization, and antimicrobial activity.	Proline	123-130	forkhead box G1	Homo sapiens	55-58
21277926-11	2011	A better understanding of the role of proline in the BF2 antimicrobial mechanism will contribute to the further design and development of BF2 analogs.	Proline	38-45	forkhead box G1	Homo sapiens	53-56
21277926-11	2011	A better understanding of the role of proline in the BF2 antimicrobial mechanism will contribute to the further design and development of BF2 analogs.	Proline	38-45	forkhead box G1	Homo sapiens	138-141
21277926-12	2011	Moreover, since proline residues are prevalent among other antimicrobial peptides, this systematic characterization of BF2 provides general insights that can promote our understanding of other systems.	Proline	16-23	forkhead box G1	Homo sapiens	119-122
21311034-2	2011	In this catabolic pathway, Pro is converted to glutamate by two reactions catalyzed by proline dehydrogenase (ProDH) and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), with Delta(1)-pyrroline-5-carboxylate (P5C) as the intermediate.	Proline	27-30	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	87-108
21241388-8	2011	The 18 amino acid proline-rich extracellular domain that is responsible for AtFH1 anchoring has homology with cell-wall extensins.	Proline	18-25	formin homology 1	Arabidopsis thaliana	76-81
21604515-2	2011	This group of proteolytic enzymes was found to cleave specific peptide bonds within the sequence TPPTPSPSTPPTPSPS (T, P and S are threonine, proline and serine residues, respectively) found in the hinge region of human IgA1.	Proline	141-148	immunoglobulin heavy constant alpha 1	Homo sapiens	219-223
21311034-2	2011	In this catabolic pathway, Pro is converted to glutamate by two reactions catalyzed by proline dehydrogenase (ProDH) and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), with Delta(1)-pyrroline-5-carboxylate (P5C) as the intermediate.	Proline	27-30	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	110-115
21311034-2	2011	In this catabolic pathway, Pro is converted to glutamate by two reactions catalyzed by proline dehydrogenase (ProDH) and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), with Delta(1)-pyrroline-5-carboxylate (P5C) as the intermediate.	Proline	27-30	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	121-167
21311034-2	2011	In this catabolic pathway, Pro is converted to glutamate by two reactions catalyzed by proline dehydrogenase (ProDH) and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), with Delta(1)-pyrroline-5-carboxylate (P5C) as the intermediate.	Proline	27-30	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	169-174
21332223-4	2011	Trimethylamine N-oxide (TMAO) and proline redirect amyloid fibrillogenesis of the pathological huntingtin exon 1 to nonamyloidogenic amorphous assemblies via two dissimilar molecular mechanisms.	Proline	34-41	huntingtin	Homo sapiens	95-105
21291263-4	2011	The PTP1B catalytic domain has modest preference for acidic residues on both sides of pY, is highly active toward multiply phosphorylated peptides, but disfavors basic residues at any position, a Gly at the pY-1 position, or a Pro at the pY+1 position.	Proline	227-230	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	4-9
21479269-5	2011	In the present study, the mutation was identified as a base substitution (T-&gt;C) in exon 56 of Myo15, leading to an amino acid exchange from leucine (Leu) to proline (Pro) within the carboxy-terminal MyTH4 domain in the proteins" tail region.	Proline	160-167	myosin XVA	Rattus norvegicus	97-102
21479269-5	2011	In the present study, the mutation was identified as a base substitution (T-&gt;C) in exon 56 of Myo15, leading to an amino acid exchange from leucine (Leu) to proline (Pro) within the carboxy-terminal MyTH4 domain in the proteins" tail region.	Proline	169-172	myosin XVA	Rattus norvegicus	97-102
21320496-3	2011	The SH3 domain of Abi-1 and the proline-rich domain of c-Abl are involved in this interaction.	Proline	32-39	abl interactor 1	Homo sapiens	18-23
21474553-6	2011	Expression of cDNA EgProT1 in Escherichia coli mutant exhibited uptake activities for glycinebetaine and choline as well as proline.	Proline	124-131	probable proline transporter 2	Elaeis guineensis	19-26
21320496-3	2011	The SH3 domain of Abi-1 and the proline-rich domain of c-Abl are involved in this interaction.	Proline	32-39	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	55-60
21884627-4	2011	The N-terminal region of XB130 includes several tyrosine phosphorylation sites and a proline-rich sequence that might interact with Src homology 2 and 3 domain-containing proteins, respectively.	Proline	85-92	actin filament associated protein 1 like 2	Homo sapiens	25-30
21349274-3	2011	This interaction is mediated through the SH3D domain of Intersectin and the central domain of CdGAP, which does not contain any typical proline-rich domain or known SH3-binding motif.	Proline	136-143	Rho GTPase activating protein 31	Homo sapiens	94-99
21383142-0	2011	Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity.	Proline	0-7	peroxisome proliferator activated receptor alpha	Homo sapiens	75-123
21383142-0	2011	Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity.	Proline	0-7	peroxisome proliferator activated receptor alpha	Homo sapiens	125-134
21383142-3	2011	The clock-controlled proline- and acidic amino acid-rich domain basic leucine zipper proteins D-site-binding protein, thyrotroph embryonic factor, and hepatic leukemia factor have previously been shown to participate in the circadian control of xenobiotic detoxification in liver and other peripheral organs.	Proline	21-28	D-box binding PAR bZIP transcription factor	Homo sapiens	94-116
21383142-3	2011	The clock-controlled proline- and acidic amino acid-rich domain basic leucine zipper proteins D-site-binding protein, thyrotroph embryonic factor, and hepatic leukemia factor have previously been shown to participate in the circadian control of xenobiotic detoxification in liver and other peripheral organs.	Proline	21-28	TEF transcription factor, PAR bZIP family member	Homo sapiens	118-145
21383142-3	2011	The clock-controlled proline- and acidic amino acid-rich domain basic leucine zipper proteins D-site-binding protein, thyrotroph embryonic factor, and hepatic leukemia factor have previously been shown to participate in the circadian control of xenobiotic detoxification in liver and other peripheral organs.	Proline	21-28	HLF transcription factor, PAR bZIP family member	Homo sapiens	151-174
21383142-4	2011	Here we present genetic and biochemical evidence that the three proline- and acidic amino acid-rich basic leucine zipper proteins also play a key role in circadian lipid metabolism by influencing the rhythmic expression and activity of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha).	Proline	64-71	peroxisome proliferator activated receptor alpha	Homo sapiens	257-305
21383142-4	2011	Here we present genetic and biochemical evidence that the three proline- and acidic amino acid-rich basic leucine zipper proteins also play a key role in circadian lipid metabolism by influencing the rhythmic expression and activity of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha).	Proline	64-71	peroxisome proliferator activated receptor alpha	Homo sapiens	307-316
21320777-3	2011	The most potent analog, 3-(5-aminocarbonylpyridyl piperidine 53j, displayed excellent DPP-4 activity with good selectivity versus other proline enzymes.	Proline	136-143	dipeptidylpeptidase 4	Rattus norvegicus	86-91
21247092-6	2011	These features are conserved during animal evolution, as even mammalian Skp1, which lacks the target proline, became a good substrate upon its restoration.	Proline	101-108	S-phase kinase associated protein 1	Homo sapiens	72-76
21220423-4	2011	Employing a chimeric approach by sequential swapping of respective intra- and extracellular regions between Orai1 and Orai3, we show here that Orai1 specific proline/arginine-rich domains in the N terminus mediate reactivation, whereas the second, intracellular loop modulates fast and slow gating processes.	Proline	158-165	ORAI calcium release-activated calcium modulator 1	Homo sapiens	108-113
21220423-4	2011	Employing a chimeric approach by sequential swapping of respective intra- and extracellular regions between Orai1 and Orai3, we show here that Orai1 specific proline/arginine-rich domains in the N terminus mediate reactivation, whereas the second, intracellular loop modulates fast and slow gating processes.	Proline	158-165	ORAI calcium release-activated calcium modulator 3	Homo sapiens	118-123
21220423-4	2011	Employing a chimeric approach by sequential swapping of respective intra- and extracellular regions between Orai1 and Orai3, we show here that Orai1 specific proline/arginine-rich domains in the N terminus mediate reactivation, whereas the second, intracellular loop modulates fast and slow gating processes.	Proline	158-165	ORAI calcium release-activated calcium modulator 1	Homo sapiens	143-148
21378985-2	2011	The Hajdu-Cheney syndrome mutations are predicted to lead to the premature truncation of NOTCH2 with either disruption or loss of the C-terminal proline-glutamate-serine-threonine-rich proteolytic recognition sequence, the absence of which has previously been shown to increase Notch signaling.	Proline	145-152	notch receptor 2	Homo sapiens	89-95
21357744-3	2011	The p53 tumor suppressor protein, an important transcriptional regulator of apoptosis, naturally occurs in humans in two variants with single nucleotide polymorphisms resulting in Arg or Pro at residue 72.	Proline	187-190	tumor protein p53	Homo sapiens	4-7
21214569-5	2011	However, the main splice form of AChE in brain lacks a transmembrane peptide anchor region and is bound to the "proline-rich membrane anchor", PRiMA, in lipid rafts.	Proline	112-119	acetylcholinesterase	Rattus norvegicus	33-37
21042277-2	2011	Cdc42 GTPase-activating protein (CdGAP) is a serine- and proline-rich RhoGAP protein showing GAP activity against both Cdc42 and Rac1 but not RhoA.	Proline	57-64	Rho GTPase activating protein 31	Mus musculus	0-31
21042277-2	2011	Cdc42 GTPase-activating protein (CdGAP) is a serine- and proline-rich RhoGAP protein showing GAP activity against both Cdc42 and Rac1 but not RhoA.	Proline	57-64	Rho GTPase activating protein 31	Mus musculus	33-38
21042277-2	2011	Cdc42 GTPase-activating protein (CdGAP) is a serine- and proline-rich RhoGAP protein showing GAP activity against both Cdc42 and Rac1 but not RhoA.	Proline	57-64	cell division cycle 42	Mus musculus	0-5
21042277-2	2011	Cdc42 GTPase-activating protein (CdGAP) is a serine- and proline-rich RhoGAP protein showing GAP activity against both Cdc42 and Rac1 but not RhoA.	Proline	57-64	Rac family small GTPase 1	Mus musculus	129-133
21042277-11	2011	Rescue analysis using re-expression of various CdGAP deletion-mutant proteins revealed that the proline-rich domain (PRD) but not the GAP domain of CdGAP is essential to mediate TGFbeta-induced cell motility and invasion.	Proline	96-103	Rho GTPase activating protein 31	Mus musculus	47-52
21042277-11	2011	Rescue analysis using re-expression of various CdGAP deletion-mutant proteins revealed that the proline-rich domain (PRD) but not the GAP domain of CdGAP is essential to mediate TGFbeta-induced cell motility and invasion.	Proline	96-103	transforming growth factor, beta 1	Mus musculus	178-185
21284559-6	2011	The specific activity of DP4 for neuropeptide Y (NPY) cleavage comprising a proline in P1-position is the same range as the k(cat)/K(m) values of NPY derivatives containing alanine or serine in P1-position with 4 x 105 M-1 s-1, 9.5 x 105 M-1 s-1 and 2.1 x 105 M-1 s-1, respectively.	Proline	76-83	neuropeptide Y	Homo sapiens	33-47
21284559-6	2011	The specific activity of DP4 for neuropeptide Y (NPY) cleavage comprising a proline in P1-position is the same range as the k(cat)/K(m) values of NPY derivatives containing alanine or serine in P1-position with 4 x 105 M-1 s-1, 9.5 x 105 M-1 s-1 and 2.1 x 105 M-1 s-1, respectively.	Proline	76-83	neuropeptide Y	Homo sapiens	49-52
21287578-3	2011	In normoxia, HIF-1alpha is destabilized by post-translational hydroxylation of Pro-564 and Pro-402 by a family of oxygen-sensitive dioxygenases.	Proline	79-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
21043833-10	2011	Interactions of betel quid with p53 genotypes in lung cancer showed significant increase for all the three genotypes, indicating a major role of betel quid (OR=5.90, CI=1.67-20.81, p=0.006; OR=5.44, CI=1.67-17.75, p=0.005; and OR=5.84, CI=1.70-19.97, p=0.005 for Arg/Arg, Arg/Pro, and Pro/Pro, respectively).	Proline	276-279	tumor protein p53	Homo sapiens	32-35
21043833-10	2011	Interactions of betel quid with p53 genotypes in lung cancer showed significant increase for all the three genotypes, indicating a major role of betel quid (OR=5.90, CI=1.67-20.81, p=0.006; OR=5.44, CI=1.67-17.75, p=0.005; and OR=5.84, CI=1.70-19.97, p=0.005 for Arg/Arg, Arg/Pro, and Pro/Pro, respectively).	Proline	285-288	tumor protein p53	Homo sapiens	32-35
21043833-10	2011	Interactions of betel quid with p53 genotypes in lung cancer showed significant increase for all the three genotypes, indicating a major role of betel quid (OR=5.90, CI=1.67-20.81, p=0.006; OR=5.44, CI=1.67-17.75, p=0.005; and OR=5.84, CI=1.70-19.97, p=0.005 for Arg/Arg, Arg/Pro, and Pro/Pro, respectively).	Proline	285-288	tumor protein p53	Homo sapiens	32-35
21421125-5	2011	Soluble and active human PHD3 was expressed in the E. coli with a Trx fusion tag under a lower induction temperature of 25 C. Mass spectrometry analysis of the resultant peptide product indicated a mass increase of 16 daltons, consistent with hydroxylation of the proline residue in the HIF-1alpha (556-574) peptide substrate.	Proline	264-271	egl-9 family hypoxia inducible factor 3	Homo sapiens	25-29
21234731-4	2011	We identified several hCB1(TMH7/H8) structure-function determinants, including multiple electrostatic amino-acid interactions and a proline kink involving the highly conserved NPXXY motif.	Proline	132-139	cannabinoid receptor 1	Homo sapiens	22-26
21143199-7	2011	A single substitution between valine and proline residues in the marked box distinguishes E2F1"s ability to interact with ppRB from the inability of E2F3 to bind to the "specific" site in ppRB.	Proline	41-48	E2F transcription factor 1	Homo sapiens	90-94
21123835-8	2011	We observed an association between TP53 alterations in the tumors and constitutive TP53 genotype (P &lt; 0.01), with alterations preferentially occurring on the proline allele.	Proline	161-168	tumor protein p53	Homo sapiens	35-39
21123835-8	2011	We observed an association between TP53 alterations in the tumors and constitutive TP53 genotype (P &lt; 0.01), with alterations preferentially occurring on the proline allele.	Proline	161-168	tumor protein p53	Homo sapiens	83-87
20623514-5	2011	We have recently characterized the individual interactions of ASPP2(ANK-SH3) with Bcl-2 and NFkappaB, as well as a regulatory intramolecular interaction with the proline rich domain of ASPP2.	Proline	162-169	tumor protein p53 binding protein 2	Homo sapiens	185-190
21214569-5	2011	However, the main splice form of AChE in brain lacks a transmembrane peptide anchor region and is bound to the "proline-rich membrane anchor", PRiMA, in lipid rafts.	Proline	112-119	proline rich membrane anchor 1	Rattus norvegicus	143-148
21264442-2	2011	The F12 of this proband had a 9775G to C mutation in exon 10 and an 11276G to A mutation in exon 13 that resulted in two amino acid substitutions of Ala324Pro (GCG CCG) in the proline-rich connecting region and Gly531Glu (GGG GAG) near the active Ser544 in the catalytic domain.	Proline	176-183	coagulation factor XII	Homo sapiens	4-7
21245379-1	2011	A common polymorphism at codon 72 in the p53 tumor suppressor gene encodes either proline (P72) or arginine (R72).	Proline	82-89	transformation related protein 53, pseudogene	Mus musculus	41-44
21245379-1	2011	A common polymorphism at codon 72 in the p53 tumor suppressor gene encodes either proline (P72) or arginine (R72).	Proline	82-89	DEAD box helicase 17	Mus musculus	91-94
21211974-4	2011	We identified a de-novo, heterozygous, missense mutation, c.2348G&gt;C (p. Arg783Pro), in exon 21 of the MYH7 gene, which encodes slow skeletal muscle fiber/beta-cardiac myosin heavy chain protein, that replaces a highly conserved arginine with a proline.	Proline	247-254	myosin heavy chain 7	Homo sapiens	105-109
21422810-2	2011	These proteolytic enzymes specifically cleave one of several post-proline peptide bonds within the hinge region of human immunoglobulin A1 (IgA1).	Proline	66-73	immunoglobulin heavy constant alpha 1	Homo sapiens	121-138
21236256-4	2011	Structural-functional studies suggest that the proline-rich motif in the N-terminus of AFAP is critical for c-Src activation, and subsequent SRE/AP-1 transactivation and the actin-binding domain in the AFAP C-terminus is negatively involved in the regulation of AFAP/c-Src mediated SRE/AP-1 transactivation.	Proline	47-54	actin filament associated protein 1	Homo sapiens	87-91
21422810-2	2011	These proteolytic enzymes specifically cleave one of several post-proline peptide bonds within the hinge region of human immunoglobulin A1 (IgA1).	Proline	66-73	immunoglobulin heavy constant alpha 1	Homo sapiens	140-144
21422810-4	2011	Cleavage of human IgA1 produced two different sized Fc fragments and N terminal sequencing of both these fragments revealed the sequence -Thr-Pro-Ser-Pro-Ser.	Proline	142-145	immunoglobulin heavy constant alpha 1	Homo sapiens	18-22
21422810-4	2011	Cleavage of human IgA1 produced two different sized Fc fragments and N terminal sequencing of both these fragments revealed the sequence -Thr-Pro-Ser-Pro-Ser.	Proline	150-153	immunoglobulin heavy constant alpha 1	Homo sapiens	18-22
21149455-7	2011	In a new peptidyl prolyl cis-trans isomerase assay, FkpA isomerized the Cma prolyl bond in peptide Phe-Pro-176 at a high rate, but Lys-Pro-107 and Leu-Pro-260 isomerized at only &lt;10% of that rate.	Proline	103-106	Colicin M activity protein	Escherichia coli	72-75
21149455-12	2011	Of the four proline residues identified as being important for Cma activity, Phe-Pro-176 is most likely targeted by FkpA.	Proline	12-19	Colicin M activity protein	Escherichia coli	63-66
21149455-12	2011	Of the four proline residues identified as being important for Cma activity, Phe-Pro-176 is most likely targeted by FkpA.	Proline	81-84	Colicin M activity protein	Escherichia coli	63-66
21224233-7	2011	We found that replacing merely the predicted fourth extracellular loop (EL4) - containing 32 amino acid residues that include 7 prolines - of human NBCe1-A with EL4 of NBCn1-A creates an electroneutral NBC.	Proline	128-136	solute carrier family 4 member 4	Homo sapiens	148-155
21228347-0	2011	Basal and antigen-induced exposure of the proline-rich sequence in CD3epsilon.	Proline	42-49	CD3 antigen, epsilon polypeptide	Mus musculus	67-77
21228347-1	2011	The CD3epsilon cytoplasmic tail contains a conserved proline-rich sequence (PRS) that influences TCR-CD3 expression and signaling.	Proline	53-60	CD3 antigen, epsilon polypeptide	Mus musculus	4-14
21228347-1	2011	The CD3epsilon cytoplasmic tail contains a conserved proline-rich sequence (PRS) that influences TCR-CD3 expression and signaling.	Proline	53-60	CD3 antigen, epsilon polypeptide	Mus musculus	4-7
21340027-6	2011	Here, we determined the underlying molecular mechanism, and found that Drk facilitates the dose-dependent regulation of EGFR signaling through binding to the proline-rich motif of D-CblL, PR.	Proline	158-165	downstream of receptor kinase	Drosophila melanogaster	71-74
21340027-6	2011	Here, we determined the underlying molecular mechanism, and found that Drk facilitates the dose-dependent regulation of EGFR signaling through binding to the proline-rich motif of D-CblL, PR.	Proline	158-165	Epidermal growth factor receptor	Drosophila melanogaster	120-124
21340027-6	2011	Here, we determined the underlying molecular mechanism, and found that Drk facilitates the dose-dependent regulation of EGFR signaling through binding to the proline-rich motif of D-CblL, PR.	Proline	158-165	Cbl proto-oncogene	Drosophila melanogaster	180-186
21146541-7	2011	Moreover, R(g) of the major component of D(phys) containing the native proline isomer (D(phys,tra)) was estimated as 23.9+-0.2 A based on R(g,0).	Proline	71-78	T cell receptor alpha locus	Homo sapiens	94-97
21512100-5	2011	The AtNHX5 plants had higher leaf water content and leaf chlorophyll contents, accumulated more proline and soluble sugars, and had less membrane damage than the WT plants under water deficiency and high saline conditions.	Proline	96-103	sodium hydrogen exchanger 5	Arabidopsis thaliana	4-10
21512100-6	2011	Taken together, the results indicate that the AtNHX5 gene could enhance the tolerance of paper mulberry plants to multiple environmental stresses by promoting the accumulation of more effective osmolytes (ions, soluble sugars, proline) to counter the osmotic stress caused by abiotic factors.	Proline	227-234	sodium hydrogen exchanger 5	Arabidopsis thaliana	46-52
21272566-2	2011	Aminotransferase of unknown stereospecificity in its PLP form was incubated in (2)H(2)O with a substrate amino acid resulted in PMP labeled with deuterium at C-4" in the pro-S or pro-R configuration according to the stereospecificity of the aminotransferase tested.	Proline	170-175	proteolipid protein 1	Homo sapiens	53-56
21272566-2	2011	Aminotransferase of unknown stereospecificity in its PLP form was incubated in (2)H(2)O with a substrate amino acid resulted in PMP labeled with deuterium at C-4" in the pro-S or pro-R configuration according to the stereospecificity of the aminotransferase tested.	Proline	170-175	complement C4A (Rodgers blood group)	Homo sapiens	158-161
21159777-4	2011	We show that the cis-Ser(P)(5)-Pro(6) isomer is the minor population in solution and that Ess1-catalyzed cis-trans-proline isomerization facilitates rapid dephosphorylation by Ssu72, providing an explanation for recently discovered in vivo connections between these enzymes and a revised model for CTD-mediated small nuclear RNA termination.	Proline	115-122	transforming growth factor beta receptor 1	Homo sapiens	90-94
21159777-4	2011	We show that the cis-Ser(P)(5)-Pro(6) isomer is the minor population in solution and that Ess1-catalyzed cis-trans-proline isomerization facilitates rapid dephosphorylation by Ssu72, providing an explanation for recently discovered in vivo connections between these enzymes and a revised model for CTD-mediated small nuclear RNA termination.	Proline	115-122	SSU72 homolog, RNA polymerase II CTD phosphatase	Homo sapiens	176-181
21350664-4	2011	Genome sequencing revealed various PPE (Proline-Proline-Glutamic acid) protein family of Map which are immunologically importance candidate genes In present study we have developed a bicistrionic construct pIR PPE/IFN containing a 34.9 kDa PPE protein (PPE 34.9) of Map along with a cytokine gene encoding murine gamma Interferon gene (IFNgamma) and a monocistrionic construct pIR PPE using a mammalian vector system pIRES 6.1.	Proline	40-47	interferon gamma	Mus musculus	313-329
21350664-4	2011	Genome sequencing revealed various PPE (Proline-Proline-Glutamic acid) protein family of Map which are immunologically importance candidate genes In present study we have developed a bicistrionic construct pIR PPE/IFN containing a 34.9 kDa PPE protein (PPE 34.9) of Map along with a cytokine gene encoding murine gamma Interferon gene (IFNgamma) and a monocistrionic construct pIR PPE using a mammalian vector system pIRES 6.1.	Proline	40-47	interferon gamma	Mus musculus	336-344
21236256-4	2011	Structural-functional studies suggest that the proline-rich motif in the N-terminus of AFAP is critical for c-Src activation, and subsequent SRE/AP-1 transactivation and the actin-binding domain in the AFAP C-terminus is negatively involved in the regulation of AFAP/c-Src mediated SRE/AP-1 transactivation.	Proline	47-54	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	108-113
21236256-4	2011	Structural-functional studies suggest that the proline-rich motif in the N-terminus of AFAP is critical for c-Src activation, and subsequent SRE/AP-1 transactivation and the actin-binding domain in the AFAP C-terminus is negatively involved in the regulation of AFAP/c-Src mediated SRE/AP-1 transactivation.	Proline	47-54	actin filament associated protein 1	Homo sapiens	202-206
21236256-4	2011	Structural-functional studies suggest that the proline-rich motif in the N-terminus of AFAP is critical for c-Src activation, and subsequent SRE/AP-1 transactivation and the actin-binding domain in the AFAP C-terminus is negatively involved in the regulation of AFAP/c-Src mediated SRE/AP-1 transactivation.	Proline	47-54	actin filament associated protein 1	Homo sapiens	202-206
21236256-4	2011	Structural-functional studies suggest that the proline-rich motif in the N-terminus of AFAP is critical for c-Src activation, and subsequent SRE/AP-1 transactivation and the actin-binding domain in the AFAP C-terminus is negatively involved in the regulation of AFAP/c-Src mediated SRE/AP-1 transactivation.	Proline	47-54	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	267-272
21051667-1	2011	OBJECTIVE: The Pin1 prolyl isomerase acts in concert with proline-directed protein kinases to regulate function of protein substrates through isomerization of peptide bonds that link phosphoserine or phosphothreonine to proline.	Proline	58-65	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Bos taurus	15-19
21301103-6	2011	Conformational heterogeneity owing to cis-trans proline isomerization in the Src homology 2 (SH2) domain of the IL-2-inducible T-cell kinase (ITK) has been extensively characterized by NMR.	Proline	48-55	IL2 inducible T cell kinase	Mus musculus	112-140
21301103-6	2011	Conformational heterogeneity owing to cis-trans proline isomerization in the Src homology 2 (SH2) domain of the IL-2-inducible T-cell kinase (ITK) has been extensively characterized by NMR.	Proline	48-55	IL2 inducible T cell kinase	Mus musculus	142-145
21301103-7	2011	Using the ITK SH2 domain as a test system, an attempt was made to determine whether proline isomerization could be detected in a crystal structure of the ITK SH2 domain.	Proline	84-91	IL2 inducible T cell kinase	Mus musculus	154-157
21281805-6	2011	Neutrophils can migrate in response to chemotactic gradients established through the action of gelatinases (eg, matrix metalloproteinase 9), which degrade collagen components of the extracellular matrix to generate tripeptide fragments of proline-glycine-proline.	Proline	239-246	matrix metallopeptidase 9	Mus musculus	112-138
21281805-6	2011	Neutrophils can migrate in response to chemotactic gradients established through the action of gelatinases (eg, matrix metalloproteinase 9), which degrade collagen components of the extracellular matrix to generate tripeptide fragments of proline-glycine-proline.	Proline	255-262	matrix metallopeptidase 9	Mus musculus	112-138
21051667-2	2011	We sought to determine whether Pin1 interacts with endothelial nitric oxide synthase (eNOS) in endothelial cells in a manner that depends on proline-directed phosphorylation of the eNOS enzyme and whether this interaction influences basal or agonist-stimulated eNOS activity.	Proline	141-148	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Bos taurus	31-35
21051667-2	2011	We sought to determine whether Pin1 interacts with endothelial nitric oxide synthase (eNOS) in endothelial cells in a manner that depends on proline-directed phosphorylation of the eNOS enzyme and whether this interaction influences basal or agonist-stimulated eNOS activity.	Proline	141-148	nitric oxide synthase 3	Bos taurus	86-90
21051667-2	2011	We sought to determine whether Pin1 interacts with endothelial nitric oxide synthase (eNOS) in endothelial cells in a manner that depends on proline-directed phosphorylation of the eNOS enzyme and whether this interaction influences basal or agonist-stimulated eNOS activity.	Proline	141-148	nitric oxide synthase 3	Bos taurus	181-185
21051667-2	2011	We sought to determine whether Pin1 interacts with endothelial nitric oxide synthase (eNOS) in endothelial cells in a manner that depends on proline-directed phosphorylation of the eNOS enzyme and whether this interaction influences basal or agonist-stimulated eNOS activity.	Proline	141-148	nitric oxide synthase 3	Bos taurus	181-185
21051667-3	2011	METHODS AND RESULTS: Inhibitors of the extracellular-regulated kinase (ERK) 1/2 MAP kinases inhibit proline-directed phosphorylation of eNOS at serine 116 (Ser116) in bovine aortic endothelial cells (BAECs).	Proline	100-107	mitogen-activated protein kinase 3	Bos taurus	39-79
21051667-3	2011	METHODS AND RESULTS: Inhibitors of the extracellular-regulated kinase (ERK) 1/2 MAP kinases inhibit proline-directed phosphorylation of eNOS at serine 116 (Ser116) in bovine aortic endothelial cells (BAECs).	Proline	100-107	nitric oxide synthase 3	Bos taurus	136-140
20609497-0	2011	Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.	Proline	59-66	nuclear receptor subfamily 1 group I member 2	Homo sapiens	80-83
20884320-8	2011	MMP-7 shows a strong preference for Leu in P(1)" and also accepts Val, Gly, and Pro at this position, whereas Ala is not preferred at P(1)".	Proline	80-83	matrix metallopeptidase 7	Homo sapiens	0-5
20972459-2	2011	YAP and TAZ both possess WW domains, which are important protein-protein interaction modules that mediate interaction with proline-rich motifs, most commonly PPXY.	Proline	123-130	Yes1 associated transcriptional regulator	Homo sapiens	0-3
20972459-2	2011	YAP and TAZ both possess WW domains, which are important protein-protein interaction modules that mediate interaction with proline-rich motifs, most commonly PPXY.	Proline	123-130	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	8-11
20609497-0	2011	Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.	Proline	59-66	NADPH oxidase activator 1	Homo sapiens	88-93
20609497-0	2011	Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.	Proline	59-66	NADPH oxidase 1	Homo sapiens	103-107
21364044-5	2011	The high number of bioactive fragments in collagen and elastin is associated with a high content of glycine and proline, amino acids that are most abundant in biologically active fragments.	Proline	112-119	elastin	Bos taurus	55-62
21097500-2	2011	Here we report the characterization of the fourth member of the family, SLC36A4 or hPAT4, which when expressed in Xenopus laevis oocytes also encodes a plasma membrane amino acid transporter, but one that is not proton-coupled and has a very high substrate affinity for the amino acids proline and tryptophan.	Proline	286-293	solute carrier family 36 (proton/amino acid symporter), member 4 L homeolog	Xenopus laevis	72-79
20673806-6	2011	The gat1 mutant exhibited impaired growth on all amino acids tested as sole nitrogen sources, with the exception of arginine and proline.	Proline	129-136	solute carrier family 6 member 1	Homo sapiens	4-8
20673806-9	2011	Microarray analysis allowed the identification of target genes that are regulated by Gat1 in the presence of proline, a poor and non-repressing nitrogen source.	Proline	109-116	solute carrier family 6 member 1	Homo sapiens	85-89
21322757-4	2011	CSL Behring has developed the L-proline-stabilized products Privigen , a 10% IgG solution for intravenous use; and Hizentra , a 20% solution for subcutaneous use.	Proline	30-39	chorionic somatomammotropin hormone like 1	Homo sapiens	0-3
21051533-8	2011	Individuals harboring the proline allele of p53 gene and the guanine allele of SNP309 showed an odds ratio of 1.67 (95% confidence interval, 1.11-2.51).	Proline	26-33	transformation related protein 53	Mus musculus	44-47
21415600-3	2011	Two enzymes of proline metabolism were analyzed in the same leaf samples and specific activities of synthetase (P5CS) and proline dehydrogenase (PDH).	Proline	15-22	Delta-1-pyrroline-5-carboxylate synthase 1	Zea mays	112-116
20419384-4	2011	PCR amplification for the analysis of p53 codon 72 arginine/proline alleles was carried out in a separate reaction.	Proline	60-67	tumor protein p53	Homo sapiens	38-41
21403836-6	2011	Importantly, this work identifies the C-terminal HVR, especially the flexible linker domain with two consecutive proline residues Pro173 and Pro174, as a critical domain that contributes to activation of H-Ras and its invasive potential in human breast epithelial cells.	Proline	113-120	HRas proto-oncogene, GTPase	Homo sapiens	204-209
21148770-0	2011	Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition.	Proline	53-60	Dcp1p	Saccharomyces cerevisiae S288C	0-4
21148770-0	2011	Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition.	Proline	53-60	decapping enzyme complex catalytic subunit	Saccharomyces cerevisiae S288C	45-49
21148770-4	2011	Edc1 and Edc2 bind Dcp1 via its EVH1 proline recognition site and stimulate decapping by 1000-fold, affecting both the K(M) for mRNA and rate of the catalytic step.	Proline	37-44	Edc1p	Saccharomyces cerevisiae S288C	0-4
21148770-4	2011	Edc1 and Edc2 bind Dcp1 via its EVH1 proline recognition site and stimulate decapping by 1000-fold, affecting both the K(M) for mRNA and rate of the catalytic step.	Proline	37-44	Edc2p	Saccharomyces cerevisiae S288C	9-13
21148770-4	2011	Edc1 and Edc2 bind Dcp1 via its EVH1 proline recognition site and stimulate decapping by 1000-fold, affecting both the K(M) for mRNA and rate of the catalytic step.	Proline	37-44	Dcp1p	Saccharomyces cerevisiae S288C	19-23
21148770-6	2011	Lesions in the Dcp1 EVH1 domain or the Edc1 proline-rich sequence are sufficient to block stimulation.	Proline	44-51	Edc1p	Saccharomyces cerevisiae S288C	39-43
21097500-2	2011	Here we report the characterization of the fourth member of the family, SLC36A4 or hPAT4, which when expressed in Xenopus laevis oocytes also encodes a plasma membrane amino acid transporter, but one that is not proton-coupled and has a very high substrate affinity for the amino acids proline and tryptophan.	Proline	286-293	solute carrier family 36 member 4	Homo sapiens	83-88
21383921-3	2011	The osmotin induced proline accumulation has been reported to confer tolerance against both biotic and abiotic stresses in plants including transgenic tomato and strawberry overexpressing osmotin gene.	Proline	20-27	osmotin	Nicotiana tabacum	4-11
21220295-3	2011	Stepwise addition of a DNA fragment containing the kappaB binding sequence to the IkappaBalpha-NF-kappaB complex results in changes in the IkappaBalpha NMR spectrum that are consistent with dissociation of the region rich in proline, glutamate, serine, and threonine (PEST) and C-terminal ankyrin repeat sequences of IkappaBalpha from the complex.	Proline	225-232	NFKB inhibitor alpha	Homo sapiens	82-94
21220295-3	2011	Stepwise addition of a DNA fragment containing the kappaB binding sequence to the IkappaBalpha-NF-kappaB complex results in changes in the IkappaBalpha NMR spectrum that are consistent with dissociation of the region rich in proline, glutamate, serine, and threonine (PEST) and C-terminal ankyrin repeat sequences of IkappaBalpha from the complex.	Proline	225-232	nuclear factor kappa B subunit 1	Homo sapiens	95-104
21220295-3	2011	Stepwise addition of a DNA fragment containing the kappaB binding sequence to the IkappaBalpha-NF-kappaB complex results in changes in the IkappaBalpha NMR spectrum that are consistent with dissociation of the region rich in proline, glutamate, serine, and threonine (PEST) and C-terminal ankyrin repeat sequences of IkappaBalpha from the complex.	Proline	225-232	NFKB inhibitor alpha	Homo sapiens	139-151
21220295-3	2011	Stepwise addition of a DNA fragment containing the kappaB binding sequence to the IkappaBalpha-NF-kappaB complex results in changes in the IkappaBalpha NMR spectrum that are consistent with dissociation of the region rich in proline, glutamate, serine, and threonine (PEST) and C-terminal ankyrin repeat sequences of IkappaBalpha from the complex.	Proline	225-232	NFKB inhibitor alpha	Homo sapiens	139-151
21383921-3	2011	The osmotin induced proline accumulation has been reported to confer tolerance against both biotic and abiotic stresses in plants including transgenic tomato and strawberry overexpressing osmotin gene.	Proline	20-27	osmotin	Nicotiana tabacum	188-195
21383921-4	2011	The exact mechanism of induction of proline by osmotin is however, not known till date.	Proline	36-43	osmotin	Nicotiana tabacum	47-54
21255728-4	2011	FK506 inhibits retrograde trafficking of H-Ras from the plasma membrane to the Golgi in a proline 179-dependent fashion, augments early GTP loading of Ras in response to growth factors, and promotes H-Ras-dependent neurite outgrowth from PC12 cells.	Proline	90-97	HRas proto-oncogene, GTPase	Rattus norvegicus	41-46
21168386-2	2011	Zyxin participates in actin dynamics by binding VASP, an interaction that occurs via proline-rich N-terminal ActA repeats.	Proline	85-92	zyxin	Canis lupus familiaris	0-5
21168386-2	2011	Zyxin participates in actin dynamics by binding VASP, an interaction that occurs via proline-rich N-terminal ActA repeats.	Proline	85-92	vasodilator-stimulated phosphoprotein	Canis lupus familiaris	48-52
21144830-0	2011	Human VAPA and the yeast VAP Scs2p with an altered proline distribution can phenocopy amyotrophic lateral sclerosis-associated VAPB(P56S).	Proline	51-58	VAMP associated protein A	Homo sapiens	6-10
21248129-4	2011	Here, we show that the SH3 (src homology 3) domain of PSD-95 interacts with a proline-rich region within the microtubule end-binding protein EB3.	Proline	78-85	discs large MAGUK scaffold protein 4	Rattus norvegicus	54-60
21248129-4	2011	Here, we show that the SH3 (src homology 3) domain of PSD-95 interacts with a proline-rich region within the microtubule end-binding protein EB3.	Proline	78-85	microtubule-associated protein, RP/EB family, member 3	Rattus norvegicus	141-144
21144830-0	2011	Human VAPA and the yeast VAP Scs2p with an altered proline distribution can phenocopy amyotrophic lateral sclerosis-associated VAPB(P56S).	Proline	51-58	phosphatidylinositol-binding protein SCS2	Saccharomyces cerevisiae S288C	29-34
21144830-0	2011	Human VAPA and the yeast VAP Scs2p with an altered proline distribution can phenocopy amyotrophic lateral sclerosis-associated VAPB(P56S).	Proline	51-58	VAMP associated protein B and C	Homo sapiens	127-131
21144830-1	2011	A human isoform of the vesicle-associated membrane protein-associated proteins (VAPs), VAPB, causes amyotrophic lateral sclerosis eight due to the missense mutation of Pro-56, whereas human VAPA and the yeast VAP Scs2p proteins are not significantly affected by similar mutations.	Proline	168-171	VAMP associated protein B and C	Homo sapiens	87-91
21144830-3	2011	Consequently, this mutation in VAPB (VAPB(P56S)) leaves a single proline in this region whereas other VAPs can retain two proline residues even if the proline equivalent to the Pro-56 is substituted.	Proline	65-72	VAMP associated protein B and C	Homo sapiens	31-36
21144830-3	2011	Consequently, this mutation in VAPB (VAPB(P56S)) leaves a single proline in this region whereas other VAPs can retain two proline residues even if the proline equivalent to the Pro-56 is substituted.	Proline	65-72	VAMP associated protein B and C	Homo sapiens	31-35
21144830-3	2011	Consequently, this mutation in VAPB (VAPB(P56S)) leaves a single proline in this region whereas other VAPs can retain two proline residues even if the proline equivalent to the Pro-56 is substituted.	Proline	122-129	VAMP associated protein B and C	Homo sapiens	31-36
21144830-3	2011	Consequently, this mutation in VAPB (VAPB(P56S)) leaves a single proline in this region whereas other VAPs can retain two proline residues even if the proline equivalent to the Pro-56 is substituted.	Proline	122-129	VAMP associated protein B and C	Homo sapiens	31-35
21144830-3	2011	Consequently, this mutation in VAPB (VAPB(P56S)) leaves a single proline in this region whereas other VAPs can retain two proline residues even if the proline equivalent to the Pro-56 is substituted.	Proline	122-129	VAMP associated protein B and C	Homo sapiens	31-36
21144830-3	2011	Consequently, this mutation in VAPB (VAPB(P56S)) leaves a single proline in this region whereas other VAPs can retain two proline residues even if the proline equivalent to the Pro-56 is substituted.	Proline	122-129	VAMP associated protein B and C	Homo sapiens	31-35
21144830-3	2011	Consequently, this mutation in VAPB (VAPB(P56S)) leaves a single proline in this region whereas other VAPs can retain two proline residues even if the proline equivalent to the Pro-56 is substituted.	Proline	177-180	VAMP associated protein B and C	Homo sapiens	31-36
21144830-3	2011	Consequently, this mutation in VAPB (VAPB(P56S)) leaves a single proline in this region whereas other VAPs can retain two proline residues even if the proline equivalent to the Pro-56 is substituted.	Proline	177-180	VAMP associated protein B and C	Homo sapiens	31-35
21144830-4	2011	When Scs2p and VAPA were mutated to be equivalent to VAPB(P56S) in terms of the distribution of proline residues in this region, Scs2p became inactive and aggregated, and VAPA localize to membranous aggregates indistinguishable from those induced by VAPB(P56S).	Proline	96-103	VAMP associated protein A	Homo sapiens	15-19
21144830-4	2011	When Scs2p and VAPA were mutated to be equivalent to VAPB(P56S) in terms of the distribution of proline residues in this region, Scs2p became inactive and aggregated, and VAPA localize to membranous aggregates indistinguishable from those induced by VAPB(P56S).	Proline	96-103	VAMP associated protein B and C	Homo sapiens	53-57
21144830-5	2011	This suggests that the appropriate distribution of three conserved prolines, not the existence of a particular proline, confers VAPA and Scs2p resistance to the Pro-56 mutation and, therefore, is critical for VAP activities.	Proline	67-75	VAMP associated protein A	Homo sapiens	128-132
21144830-5	2011	This suggests that the appropriate distribution of three conserved prolines, not the existence of a particular proline, confers VAPA and Scs2p resistance to the Pro-56 mutation and, therefore, is critical for VAP activities.	Proline	67-75	phosphatidylinositol-binding protein SCS2	Saccharomyces cerevisiae S288C	137-142
21144830-5	2011	This suggests that the appropriate distribution of three conserved prolines, not the existence of a particular proline, confers VAPA and Scs2p resistance to the Pro-56 mutation and, therefore, is critical for VAP activities.	Proline	67-74	VAMP associated protein A	Homo sapiens	128-132
21144830-5	2011	This suggests that the appropriate distribution of three conserved prolines, not the existence of a particular proline, confers VAPA and Scs2p resistance to the Pro-56 mutation and, therefore, is critical for VAP activities.	Proline	67-74	phosphatidylinositol-binding protein SCS2	Saccharomyces cerevisiae S288C	137-142
21144830-5	2011	This suggests that the appropriate distribution of three conserved prolines, not the existence of a particular proline, confers VAPA and Scs2p resistance to the Pro-56 mutation and, therefore, is critical for VAP activities.	Proline	161-164	VAMP associated protein A	Homo sapiens	128-132
21144830-5	2011	This suggests that the appropriate distribution of three conserved prolines, not the existence of a particular proline, confers VAPA and Scs2p resistance to the Pro-56 mutation and, therefore, is critical for VAP activities.	Proline	161-164	phosphatidylinositol-binding protein SCS2	Saccharomyces cerevisiae S288C	137-142
21219594-1	2011	BACKGROUND: Peptidyl-prolyl cis/trans isomerase (Pin1), encoded by PIN1 gene with locus in chromosome 19p13, is an enzyme that catalytically induces conformational changes in proteins after phosphorylation on serine or threonine residues preceding proline (pSer/Thr-Pro motifs); in this way, it has an influence on protein interactions and intracellular localizations of proteins.	Proline	248-255	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	49-53
21071439-4	2011	Here, we show that Raptor, an essential scaffolding protein of the mTOR complex 1 (mTORC1), becomes phosphorylated on proline-directed sites following activation of the Ras/MAPK pathway.	Proline	118-125	regulatory associated protein of MTOR complex 1	Homo sapiens	19-25
21071439-4	2011	Here, we show that Raptor, an essential scaffolding protein of the mTOR complex 1 (mTORC1), becomes phosphorylated on proline-directed sites following activation of the Ras/MAPK pathway.	Proline	118-125	mechanistic target of rapamycin kinase	Homo sapiens	67-71
21071439-4	2011	Here, we show that Raptor, an essential scaffolding protein of the mTOR complex 1 (mTORC1), becomes phosphorylated on proline-directed sites following activation of the Ras/MAPK pathway.	Proline	118-125	CREB regulated transcription coactivator 1	Mus musculus	83-89
21219594-1	2011	BACKGROUND: Peptidyl-prolyl cis/trans isomerase (Pin1), encoded by PIN1 gene with locus in chromosome 19p13, is an enzyme that catalytically induces conformational changes in proteins after phosphorylation on serine or threonine residues preceding proline (pSer/Thr-Pro motifs); in this way, it has an influence on protein interactions and intracellular localizations of proteins.	Proline	248-255	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	67-71
21071439-4	2011	Here, we show that Raptor, an essential scaffolding protein of the mTOR complex 1 (mTORC1), becomes phosphorylated on proline-directed sites following activation of the Ras/MAPK pathway.	Proline	118-125	mitogen-activated protein kinase 3	Homo sapiens	173-177
21071439-6	2011	Using mass spectrometry and phosphospecific antibodies, we found three proline-directed residues within Raptor, Ser(8), Ser(696), and Ser(863), which are directly phosphorylated by ERK1/2.	Proline	71-78	regulatory associated protein of MTOR complex 1	Homo sapiens	104-110
20818436-7	2011	This process is mediated by a novel Itch-dependent degron, composed of a combination of two PPXYs and a phospho-serine/proline motifs, localized in Gli1 C-terminal region, indicating the role of two different WW docking sites in Gli1 ubiquitination.	Proline	119-126	itchy E3 ubiquitin protein ligase	Homo sapiens	36-40
21219594-1	2011	BACKGROUND: Peptidyl-prolyl cis/trans isomerase (Pin1), encoded by PIN1 gene with locus in chromosome 19p13, is an enzyme that catalytically induces conformational changes in proteins after phosphorylation on serine or threonine residues preceding proline (pSer/Thr-Pro motifs); in this way, it has an influence on protein interactions and intracellular localizations of proteins.	Proline	266-269	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	49-53
20818436-7	2011	This process is mediated by a novel Itch-dependent degron, composed of a combination of two PPXYs and a phospho-serine/proline motifs, localized in Gli1 C-terminal region, indicating the role of two different WW docking sites in Gli1 ubiquitination.	Proline	119-126	GLI family zinc finger 1	Homo sapiens	148-152
21071439-6	2011	Using mass spectrometry and phosphospecific antibodies, we found three proline-directed residues within Raptor, Ser(8), Ser(696), and Ser(863), which are directly phosphorylated by ERK1/2.	Proline	71-78	mitogen-activated protein kinase 3	Homo sapiens	181-187
21219594-1	2011	BACKGROUND: Peptidyl-prolyl cis/trans isomerase (Pin1), encoded by PIN1 gene with locus in chromosome 19p13, is an enzyme that catalytically induces conformational changes in proteins after phosphorylation on serine or threonine residues preceding proline (pSer/Thr-Pro motifs); in this way, it has an influence on protein interactions and intracellular localizations of proteins.	Proline	266-269	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	67-71
21253568-5	2011	Rice MEL2 protein discovered in this study shows partial similarity with human proline-rich RRM protein, deleted in Azoospermia-Associated Protein1 (DAZAP1), though MEL2 also possesses ankyrin repeats and a RING finger motif.	Proline	79-86	DAZ associated protein 1	Homo sapiens	105-147
21253568-5	2011	Rice MEL2 protein discovered in this study shows partial similarity with human proline-rich RRM protein, deleted in Azoospermia-Associated Protein1 (DAZAP1), though MEL2 also possesses ankyrin repeats and a RING finger motif.	Proline	79-86	DAZ associated protein 1	Homo sapiens	149-155
21598212-6	2011	PCR amplification of TP53 codon 72 polymorphism: TP53 codon 72 genotypes were detected by PCR using specific primer pairs for amplifying the proline or the arginine Alleles.	Proline	141-148	tumor protein p53	Homo sapiens	21-25
21598212-6	2011	PCR amplification of TP53 codon 72 polymorphism: TP53 codon 72 genotypes were detected by PCR using specific primer pairs for amplifying the proline or the arginine Alleles.	Proline	141-148	tumor protein p53	Homo sapiens	49-53
21598212-13	2011	In control samples, the genotype distribution for TP53 polymorphism showed 30.4%, 45.2% and 24.4% for the arginine/arginine, arginine/proline and proline/proline genotypes, respectively.	Proline	134-141	tumor protein p53	Homo sapiens	50-54
21598212-13	2011	In control samples, the genotype distribution for TP53 polymorphism showed 30.4%, 45.2% and 24.4% for the arginine/arginine, arginine/proline and proline/proline genotypes, respectively.	Proline	146-153	tumor protein p53	Homo sapiens	50-54
21598212-13	2011	In control samples, the genotype distribution for TP53 polymorphism showed 30.4%, 45.2% and 24.4% for the arginine/arginine, arginine/proline and proline/proline genotypes, respectively.	Proline	146-153	tumor protein p53	Homo sapiens	50-54
20033827-2	2011	The proline residue in position 14 of Pin2 was substituted by [V], [GV], [VG] and [GVG].	Proline	4-11	telomeric repeat binding factor 1	Homo sapiens	38-42
21204228-12	2011	The sequence variant in this family is the only reported Y-position proline substitution in the triple helical domain (Gly-X-Y) of the proalpha1(II) coded by the COL2A1 gene.	Proline	68-75	collagen type II alpha 1 chain	Homo sapiens	162-168
21332356-2	2011	Titin is responsible for the passive elasticity in muscle and is a chain composed of immunoglobulin (Ig)-like and fibronectin III (FN-III)-like domains, as well as PEVK segments rich in proline (P), glutamate (E), valine (V), and lysine (K).	Proline	186-193	titin	Homo sapiens	0-5
21040803-8	2011	Thus, proline substitutions in the N-terminal domain of apoA-I that destabilized the helix bundle promoted lipid solubilization.	Proline	6-13	apolipoprotein A1	Homo sapiens	56-62
21790217-3	2011	The ERE-linked p53 gene with the proline variant at codon 72 showed lower transfection rates than the gene without ERE or with the arginine variant at codon 72.	Proline	33-40	tumor protein p53	Homo sapiens	15-18
21790217-4	2011	p21 expression was significantly higher in HHUA cells transfected with the proline variant gene than in those transfected with the arginine variant gene.	Proline	75-82	H3 histone pseudogene 16	Homo sapiens	0-3
21790217-5	2011	We consider that the presence of an upstream ERE promotes the transcriptional effects of the exogenous p53 gene with the proline variant, which strengthens the expression of p21, and results in lower transfection rates through cell cycle inhibition.	Proline	121-128	tumor protein p53	Homo sapiens	103-106
21790217-5	2011	We consider that the presence of an upstream ERE promotes the transcriptional effects of the exogenous p53 gene with the proline variant, which strengthens the expression of p21, and results in lower transfection rates through cell cycle inhibition.	Proline	121-128	H3 histone pseudogene 16	Homo sapiens	174-177
20691150-10	2011	Although neither 5-hydroxy-l-tryptophan nor alpha-methyl-d,l-tryptophan were able to elicit inward current in PAT2-expressing oocytes both reduced the current evoked by l-proline.	Proline	169-178	solute carrier family 36 member 2	Homo sapiens	110-114
21212517-6	2011	Here we show that the proline-rich domain is critical for FGD1-induced directionally persistent cell migration.	Proline	22-29	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	58-62
22393962-7	2011	CONCLUSIONS: Our results suggest that the codon 72 SNP which results in amino acid substitution of Arginine to Proline in cell cycle regulatory gene P53, is associated with sporadic CRC risk and carriers of Pro/Pro genotype and more than 50 years old may have high susceptibility.	Proline	111-118	tumor protein p53	Homo sapiens	149-152
20691150-1	2011	The H(+)-coupled amino acid transporter PAT2 (SLC36A2) transports the amino acids proline, glycine, alanine and hydroxyproline.	Proline	82-89	solute carrier family 36 member 2	Homo sapiens	40-44
20691150-1	2011	The H(+)-coupled amino acid transporter PAT2 (SLC36A2) transports the amino acids proline, glycine, alanine and hydroxyproline.	Proline	82-89	solute carrier family 36 member 2	Homo sapiens	46-53
20691150-6	2011	In general, the proline derivatives appeared to be transported substrates and the relative ability to induce current flow was closely related to the inhibitory effects on PAT2-mediated l-[(3)H]proline uptake.	Proline	16-23	solute carrier family 36 member 2	Homo sapiens	171-175
21597170-2	2011	These Hyp residues are generated from peptidyl proline residues by the action of prolyl 4-hydroxylase which requires the ferrous ion.	Proline	47-54	probable prolyl 4-hydroxylase 9	Nicotiana tabacum	81-101
21144757-5	2011	Cyclin dependent kinase 5 (CDK5), when activated by the regulatory binding protein p25, phosphorylates tau at a number of proline-directed serine/threonine residues, resulting in formation of phosphorylated tau as paired helical filaments (PHFs) then in subsequent deposition of PHFs as NFTs.	Proline	122-129	cyclin dependent kinase 5	Homo sapiens	0-25
21144757-5	2011	Cyclin dependent kinase 5 (CDK5), when activated by the regulatory binding protein p25, phosphorylates tau at a number of proline-directed serine/threonine residues, resulting in formation of phosphorylated tau as paired helical filaments (PHFs) then in subsequent deposition of PHFs as NFTs.	Proline	122-129	cyclin dependent kinase 5	Homo sapiens	27-31
21144757-5	2011	Cyclin dependent kinase 5 (CDK5), when activated by the regulatory binding protein p25, phosphorylates tau at a number of proline-directed serine/threonine residues, resulting in formation of phosphorylated tau as paired helical filaments (PHFs) then in subsequent deposition of PHFs as NFTs.	Proline	122-129	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	83-86
21150131-4	2011	Dynamin 2 intensely localized at the mitotic spindle, and the localization depended on its proline-rich domain (PRD), which is required for microtubule association.	Proline	91-98	dynamin 2	Homo sapiens	0-9
22116359-8	2011	CONCLUSION: Amino acid substitutions involving a proline always result in a severe loss of function of pendrin.	Proline	49-56	solute carrier family 26 member 4	Homo sapiens	103-110
21916235-0	2011	[Study of gly-proline-containing peptides (PGP and GPGPGP) degradation by aggressive factors in vitro].	Proline	14-21	phosphoglycolate phosphatase	Rattus norvegicus	43-46
21510839-1	2011	Dipeptidyl peptidase-IV (DPP-IV), a serine protease that specifically cleaves the N-terminal dipeptide with a preference for L-proline or L-alanine at the penultimate position, is involved in the degradation of incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).	Proline	125-134	dipeptidyl peptidase 4	Homo sapiens	0-23
22162806-3	2011	A proline-rich and O-glycosylated 11-amino acid C-terminal repeat sequence (VNTR) previously reported for human and other higher primate CEL proteins was also observed for other eutherian mammalian CEL sequences examined.	Proline	2-9	carboxyl ester lipase	Homo sapiens	137-140
22162806-3	2011	A proline-rich and O-glycosylated 11-amino acid C-terminal repeat sequence (VNTR) previously reported for human and other higher primate CEL proteins was also observed for other eutherian mammalian CEL sequences examined.	Proline	2-9	carboxyl ester lipase	Homo sapiens	198-201
21785006-7	2011	Interaction with HIF-1alpha is facilitated by hydroxylation of PKM2 at proline-403 and -408 by PHD3.	Proline	71-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
21785006-7	2011	Interaction with HIF-1alpha is facilitated by hydroxylation of PKM2 at proline-403 and -408 by PHD3.	Proline	71-78	pyruvate kinase M1/2	Homo sapiens	63-67
21785006-7	2011	Interaction with HIF-1alpha is facilitated by hydroxylation of PKM2 at proline-403 and -408 by PHD3.	Proline	71-78	egl-9 family hypoxia inducible factor 3	Homo sapiens	95-99
21510839-1	2011	Dipeptidyl peptidase-IV (DPP-IV), a serine protease that specifically cleaves the N-terminal dipeptide with a preference for L-proline or L-alanine at the penultimate position, is involved in the degradation of incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).	Proline	125-134	dipeptidyl peptidase 4	Homo sapiens	25-31
21510839-1	2011	Dipeptidyl peptidase-IV (DPP-IV), a serine protease that specifically cleaves the N-terminal dipeptide with a preference for L-proline or L-alanine at the penultimate position, is involved in the degradation of incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).	Proline	125-134	glucagon	Homo sapiens	240-263
21510839-1	2011	Dipeptidyl peptidase-IV (DPP-IV), a serine protease that specifically cleaves the N-terminal dipeptide with a preference for L-proline or L-alanine at the penultimate position, is involved in the degradation of incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).	Proline	125-134	glucagon	Homo sapiens	265-270
21510839-1	2011	Dipeptidyl peptidase-IV (DPP-IV), a serine protease that specifically cleaves the N-terminal dipeptide with a preference for L-proline or L-alanine at the penultimate position, is involved in the degradation of incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).	Proline	125-134	gastric inhibitory polypeptide	Homo sapiens	276-320
21510839-1	2011	Dipeptidyl peptidase-IV (DPP-IV), a serine protease that specifically cleaves the N-terminal dipeptide with a preference for L-proline or L-alanine at the penultimate position, is involved in the degradation of incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).	Proline	125-134	gastric inhibitory polypeptide	Homo sapiens	322-325
22312458-2	2011	The present study used an immunohistochemical double-labeling approach to determine whether intracisternally injected L-proline in freely moving rats, which increases blood pressure, activates hypothalamic vasopressin-expressing neurons and ventral medullary tyrosine-hydroxylase- (TH-) containing neurons.	Proline	118-127	arginine vasopressin	Rattus norvegicus	206-217
21258150-1	2011	The cell fate determinant Numb exists in four alternatively spliced variants that differ in the length of their PTB (phosphotyrosine-binding domain, either lacking or containing an 11 amino acid insertion) and PRR (proline-rich region, either lacking or containing a 48 amino acid insertion).	Proline	215-222	NUMB endocytic adaptor protein	Mus musculus	26-30
22312458-3	2011	Following injection of L-proline, the number of activated hypothalamic neurons that coexpressed vasopressin and c-Fos was much greater in the supraoptic nucleus (SON) than in the paraventricular nucleus (PVN) of rats with increased blood pressure.	Proline	23-32	arginine vasopressin	Rattus norvegicus	96-107
22312458-3	2011	Following injection of L-proline, the number of activated hypothalamic neurons that coexpressed vasopressin and c-Fos was much greater in the supraoptic nucleus (SON) than in the paraventricular nucleus (PVN) of rats with increased blood pressure.	Proline	23-32	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	112-117
22312458-5	2011	These results clearly demonstrate that intracisternally injected L-proline activates hypothalamic supraoptic, but not paraventricular, vasopressin-expressing neurons and medullary TH-containing (A1/C1) neurons in freely moving rats.	Proline	65-74	arginine vasopressin	Rattus norvegicus	135-146
22312458-5	2011	These results clearly demonstrate that intracisternally injected L-proline activates hypothalamic supraoptic, but not paraventricular, vasopressin-expressing neurons and medullary TH-containing (A1/C1) neurons in freely moving rats.	Proline	65-74	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	195-201
20833209-8	2011	The S2 subsites of both DPAP1 and cathepsin C accepted aliphatic hydrophobic residues, proline, and some polar residues, yielding a distinct specificity profile.	Proline	87-94	cathepsin C	Homo sapiens	34-45
21325775-10	2011	This mutation denoted an amino acid substitution of arginine residue for the proline residue at position 158 of apoE.	Proline	77-84	apolipoprotein E	Homo sapiens	112-116
20978968-7	2011	POP is a ubiquitous post-proline cleaving enzyme with particularly high expression levels in the mammalian brain, where it participates in the metabolism of neuroactive peptides and peptide-like hormones (e.g. thyroliberin, gonadotropin-releasing hormone).	Proline	25-32	prolyl endopeptidase	Homo sapiens	0-3
21467726-3	2011	Here, we present a case of LPG caused by a novel mutation that we named ApoE2 Kurashiki, which substitutes arginine with proline at apoE codon 158.	Proline	121-128	apolipoprotein E	Homo sapiens	72-77
21467726-3	2011	Here, we present a case of LPG caused by a novel mutation that we named ApoE2 Kurashiki, which substitutes arginine with proline at apoE codon 158.	Proline	121-128	apolipoprotein E	Homo sapiens	132-136
21254236-2	2011	Prolidase has an important role in the recycling of proline for collagen synthesis and cell growth.	Proline	52-59	peptidase D	Homo sapiens	0-9
20829344-3	2011	The glutamyl-prolyl tRNA synthetase (EPRS) of bilaterian animals is unique among AARSs, containing two functional enzymes catalyzing ligation of glutamate and proline to their cognate transfer RNAs (tRNAs).	Proline	159-166	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	4-35
20829344-3	2011	The glutamyl-prolyl tRNA synthetase (EPRS) of bilaterian animals is unique among AARSs, containing two functional enzymes catalyzing ligation of glutamate and proline to their cognate transfer RNAs (tRNAs).	Proline	159-166	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	37-41
21103487-0	2011	Enhancing the thermal stability of a single-chain Fv fragment by in vivo global fluorination of the proline residues.	Proline	100-107	immunglobulin heavy chain variable region	Homo sapiens	37-52
21103487-6	2011	Hence we exploited the usage of fluoroproline to enhance the thermal stability of scFv by replacing the natural proline on the framework regions of scFv that influence the folding or stability.	Proline	38-45	immunglobulin heavy chain variable region	Homo sapiens	82-86
21067453-10	2011	Here we find that the XXX amino acids, specifically the position of a proline -2 from the dileucine residues, influence the affinity of APs for GLUT8 and GLUT12.	Proline	70-77	solute carrier family 2 member 12	Homo sapiens	144-149
21103487-6	2011	Hence we exploited the usage of fluoroproline to enhance the thermal stability of scFv by replacing the natural proline on the framework regions of scFv that influence the folding or stability.	Proline	38-45	immunglobulin heavy chain variable region	Homo sapiens	148-152
21103487-11	2011	Moreover the scFv sequence based statistical analysis strongly supports the fact that this method can be applied to any target scFv, since they contain high frequency conserved proline sites in their framework regions.	Proline	177-184	immunglobulin heavy chain variable region	Homo sapiens	13-17
21103487-11	2011	Moreover the scFv sequence based statistical analysis strongly supports the fact that this method can be applied to any target scFv, since they contain high frequency conserved proline sites in their framework regions.	Proline	177-184	immunglobulin heavy chain variable region	Homo sapiens	127-131
20974802-4	2011	On the basis of a kinome-wide small interfering RNA (siRNA) screen and confirmative biochemical analysis, we show that several proline-directed mitogen-activated protein kinases (MAPKs), such as p38, ERK1/2, and JNK1 are sufficient and required for the phosphorylation of PPPS/TP motifs of LRP6.	Proline	127-134	mitogen-activated protein kinase 1	Homo sapiens	195-198
20974802-4	2011	On the basis of a kinome-wide small interfering RNA (siRNA) screen and confirmative biochemical analysis, we show that several proline-directed mitogen-activated protein kinases (MAPKs), such as p38, ERK1/2, and JNK1 are sufficient and required for the phosphorylation of PPPS/TP motifs of LRP6.	Proline	127-134	mitogen-activated protein kinase 3	Homo sapiens	200-206
20974802-4	2011	On the basis of a kinome-wide small interfering RNA (siRNA) screen and confirmative biochemical analysis, we show that several proline-directed mitogen-activated protein kinases (MAPKs), such as p38, ERK1/2, and JNK1 are sufficient and required for the phosphorylation of PPPS/TP motifs of LRP6.	Proline	127-134	mitogen-activated protein kinase 8	Homo sapiens	212-216
20974802-4	2011	On the basis of a kinome-wide small interfering RNA (siRNA) screen and confirmative biochemical analysis, we show that several proline-directed mitogen-activated protein kinases (MAPKs), such as p38, ERK1/2, and JNK1 are sufficient and required for the phosphorylation of PPPS/TP motifs of LRP6.	Proline	127-134	LDL receptor related protein 6	Homo sapiens	290-294
21067453-10	2011	Here we find that the XXX amino acids, specifically the position of a proline -2 from the dileucine residues, influence the affinity of APs for GLUT8 and GLUT12.	Proline	70-77	solute carrier family 2 member 12	Homo sapiens	154-160
21131971-0	2011	Structural basis for regulation of the Crk signaling protein by a proline switch.	Proline	66-73	CRK proto-oncogene, adaptor protein	Homo sapiens	39-42
21850167-12	2011	Screening for mutations in exons 2- 6 of LMX1B showed a heterozygous missense mutation c.194 A&gt;C changing glutamine to proline within exon 2 in codon 65 (Q65P) of the coding sequence.	Proline	122-129	LIM homeobox transcription factor 1 beta	Homo sapiens	41-46
21131971-2	2011	Here we report the structures of both the cis and trans conformers of a proline switch in the Crk signaling protein.	Proline	72-79	CRK proto-oncogene, adaptor protein	Homo sapiens	94-97
21131971-4	2011	In addition to acting as a structural switch, the heterogeneous proline recruits cyclophilin A, which accelerates the interconversion rate between the isomers, thereby regulating the kinetics of Crk activation.	Proline	64-71	CRK proto-oncogene, adaptor protein	Homo sapiens	195-198
21695085-4	2011	Immunodepletion and competition experiments with recombinant SHIP domains revealed that Grb2 and the proline-rich domain of SHIP were necessary for SHIP-LyGDI association.	Proline	101-108	inositol polyphosphate-5-phosphatase D	Homo sapiens	61-65
20838887-0	2011	Proline-rich cytokine from neurosecretory granules: a new natural substrate for dipeptidyl peptidase IV.	Proline	0-7	dipeptidyl peptidase 4	Bos taurus	80-103
21778786-0	2011	P53 codon 72 (Arg72Pro) polymorphism and prostate cancer risk: association between disease onset and proline genotype.	Proline	101-108	tumor protein p53	Homo sapiens	0-3
21998713-9	2011	Within the 22q11DS group we further demonstrated an association between high plasma proline levels and aberrant feedback/feedforward ratios, which was moderated by the COMT(158) genotype.	Proline	84-91	catechol-O-methyltransferase	Homo sapiens	168-172
21858044-10	2011	RESULTS: There was evidence of association between the single nucleotide polymorphism rs17368528 in exon five of the H6PD gene, which encodes an amino-acid change from proline to leucine in the H6PDH protein, and mean carotid intima-medial thickness (p = 0.00065).	Proline	168-175	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	117-121
21747913-5	2011	Our data suggests that alternative splicing of the Rbfox3 pre-mRNA itself leads to the production of four protein isoforms that migrate in the 45-50 kDa range, and that one of these splicing choices regulates Rbfox3/NeuN sub-cellular steady-state distribution, through the addition or removal of a short C-terminal extension containing the second half of a bipartite hydrophobic proline-tyrosine nuclear localization signal.	Proline	379-386	RNA binding fox-1 homolog 3	Homo sapiens	51-57
21747913-5	2011	Our data suggests that alternative splicing of the Rbfox3 pre-mRNA itself leads to the production of four protein isoforms that migrate in the 45-50 kDa range, and that one of these splicing choices regulates Rbfox3/NeuN sub-cellular steady-state distribution, through the addition or removal of a short C-terminal extension containing the second half of a bipartite hydrophobic proline-tyrosine nuclear localization signal.	Proline	379-386	RNA binding fox-1 homolog 3	Homo sapiens	209-215
21747913-5	2011	Our data suggests that alternative splicing of the Rbfox3 pre-mRNA itself leads to the production of four protein isoforms that migrate in the 45-50 kDa range, and that one of these splicing choices regulates Rbfox3/NeuN sub-cellular steady-state distribution, through the addition or removal of a short C-terminal extension containing the second half of a bipartite hydrophobic proline-tyrosine nuclear localization signal.	Proline	379-386	RNA binding fox-1 homolog 3	Homo sapiens	216-220
20926417-0	2011	Analogs of the CLV3 peptide: synthesis and structure-activity relationships focused on proline residues.	Proline	87-94	CLAVATA3	Arabidopsis thaliana	15-19
20926417-1	2011	CLAVATA3 (CLV3) is a plant peptide hormone in which the proline residues are post-translationally hydroxylated and glycosylated.	Proline	56-63	CLAVATA3	Arabidopsis thaliana	0-8
20926417-1	2011	CLAVATA3 (CLV3) is a plant peptide hormone in which the proline residues are post-translationally hydroxylated and glycosylated.	Proline	56-63	CLAVATA3	Arabidopsis thaliana	10-14
21738766-5	2011	People with 22q11DS are vulnerable for haploinsufficiency of PRODH, a gene that codes for an enzyme converting proline into glutamate.	Proline	111-118	proline dehydrogenase 1	Homo sapiens	61-66
21695085-4	2011	Immunodepletion and competition experiments with recombinant SHIP domains revealed that Grb2 and the proline-rich domain of SHIP were necessary for SHIP-LyGDI association.	Proline	101-108	inositol polyphosphate-5-phosphatase D	Homo sapiens	124-128
21695085-4	2011	Immunodepletion and competition experiments with recombinant SHIP domains revealed that Grb2 and the proline-rich domain of SHIP were necessary for SHIP-LyGDI association.	Proline	101-108	inositol polyphosphate-5-phosphatase D	Homo sapiens	124-128
21695085-4	2011	Immunodepletion and competition experiments with recombinant SHIP domains revealed that Grb2 and the proline-rich domain of SHIP were necessary for SHIP-LyGDI association.	Proline	101-108	Rho GDP dissociation inhibitor beta	Homo sapiens	153-158
21695158-1	2011	BACKGROUND: Proline-, glutamic acid-, and leucine-rich protein (PELP1) is a novel nuclear receptor coregulator with a multitude of functions.	Proline	12-19	proline, glutamate and leucine rich protein 1	Homo sapiens	64-69
20828617-3	2011	We chose to use the Bac-to-Bac baculovirus-insect cell system to express a His-tagged form of human GAPDHS (Hu his-GAPDHS) lacking the proline-rich N-terminal sequence.	Proline	135-142	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Homo sapiens	100-106
21191700-7	2011	The details of LKB1 alterations were: one 5 bp deletion in intron 5, one Gly to Phe substitution at codon 279 of exon 6, and three Pro to Leu substitutions at codon 281 of exon 6.	Proline	131-134	serine/threonine kinase 11	Homo sapiens	15-19
21056617-10	2011	The proline switch in the tau conformation triggers dephosphorylation of Ser/Thr residues phosphorylated, e.g. by two well-known tau kinases Cdk5 and GSK-3beta.	Proline	4-11	microtubule associated protein tau	Homo sapiens	26-29
21056617-10	2011	The proline switch in the tau conformation triggers dephosphorylation of Ser/Thr residues phosphorylated, e.g. by two well-known tau kinases Cdk5 and GSK-3beta.	Proline	4-11	microtubule associated protein tau	Homo sapiens	129-132
21056617-10	2011	The proline switch in the tau conformation triggers dephosphorylation of Ser/Thr residues phosphorylated, e.g. by two well-known tau kinases Cdk5 and GSK-3beta.	Proline	4-11	cyclin dependent kinase 5	Homo sapiens	141-145
21056617-10	2011	The proline switch in the tau conformation triggers dephosphorylation of Ser/Thr residues phosphorylated, e.g. by two well-known tau kinases Cdk5 and GSK-3beta.	Proline	4-11	glycogen synthase kinase 3 alpha	Homo sapiens	150-159
21093412-2	2010	Some of these Nef activities are mediated by the well-conserved proline-rich region of Nef, and this region is highly targeted by cytotoxic T lymphocytes (CTLs).	Proline	64-71	S100 calcium binding protein B	Homo sapiens	14-17
20947499-0	2010	Proline periodicity modulates the self-assembly properties of elastin-like polypeptides.	Proline	0-7	elastin	Homo sapiens	62-69
20947499-2	2010	The monomeric precursor, tropoelastin, is highly hydrophobic yet remains substantially disordered and flexible in solution, due in large part to a high combined threshold of proline and glycine residues within hydrophobic sequences.	Proline	174-181	elastin	Homo sapiens	25-37
20947499-3	2010	In fact, proline-poor elastin-like sequences are known to form amyloid-like fibrils, rich in beta-structure, from solution.	Proline	9-16	elastin	Homo sapiens	22-29
20947499-5	2010	However, a small number of hydrophobic domains near the C terminus of tropoelastin are substantially depleted of proline residues.	Proline	113-120	elastin	Homo sapiens	70-82
20947499-6	2010	Here we investigated the specific contribution of proline number and spacing to the structure and self-assembly propensities of elastin-like polypeptides.	Proline	50-57	elastin	Homo sapiens	128-135
20947499-10	2010	These data strongly support a model where proline-poor regions of the elastin monomer provide a unique contribution to assembly and suggest a role for localized beta-sheet in mediating self-assembly interactions.	Proline	42-49	elastin	Homo sapiens	70-77
21082776-4	2010	Analysis of dynamin hybrids and of dynamin 1-dynamin 2 and dynamin 1-dynamin 3 heteropolymers reveals that concentration-dependent GTPase activation is suppressed by the C-terminal proline/arginine-rich domain of dynamin 1.	Proline	181-188	dynamin 1	Homo sapiens	35-44
21082776-4	2010	Analysis of dynamin hybrids and of dynamin 1-dynamin 2 and dynamin 1-dynamin 3 heteropolymers reveals that concentration-dependent GTPase activation is suppressed by the C-terminal proline/arginine-rich domain of dynamin 1.	Proline	181-188	dynamin 2	Homo sapiens	45-54
21082776-4	2010	Analysis of dynamin hybrids and of dynamin 1-dynamin 2 and dynamin 1-dynamin 3 heteropolymers reveals that concentration-dependent GTPase activation is suppressed by the C-terminal proline/arginine-rich domain of dynamin 1.	Proline	181-188	dynamin 1	Homo sapiens	59-68
21082776-4	2010	Analysis of dynamin hybrids and of dynamin 1-dynamin 2 and dynamin 1-dynamin 3 heteropolymers reveals that concentration-dependent GTPase activation is suppressed by the C-terminal proline/arginine-rich domain of dynamin 1.	Proline	181-188	dynamin 3	Homo sapiens	69-78
21082776-4	2010	Analysis of dynamin hybrids and of dynamin 1-dynamin 2 and dynamin 1-dynamin 3 heteropolymers reveals that concentration-dependent GTPase activation is suppressed by the C-terminal proline/arginine-rich domain of dynamin 1.	Proline	181-188	dynamin 1	Homo sapiens	59-68
21093412-2	2010	Some of these Nef activities are mediated by the well-conserved proline-rich region of Nef, and this region is highly targeted by cytotoxic T lymphocytes (CTLs).	Proline	64-71	S100 calcium binding protein B	Homo sapiens	87-90
21093412-4	2010	The analysis of autologous nef sequences isolated from a cohort of total 235 subjects in Japan revealed that the subjects showing amino acid variations, such as Arg75Thr and Tyr85Phe, located within the proline-rich region were significantly over-represented by those having HLA-B*3501.	Proline	203-210	S100 calcium binding protein B	Homo sapiens	27-30
21093412-4	2010	The analysis of autologous nef sequences isolated from a cohort of total 235 subjects in Japan revealed that the subjects showing amino acid variations, such as Arg75Thr and Tyr85Phe, located within the proline-rich region were significantly over-represented by those having HLA-B*3501.	Proline	203-210	major histocompatibility complex, class I, B	Homo sapiens	275-280
21098279-6	2010	Strikingly, the specificity pocket of IRTKS SH3 has evolved to accommodate a polyproline type II helical peptide analogously to docking of the canonical PxxP by the conserved IRTKS SH3 proline-binding pockets.	Proline	81-88	BAR/IMD domain containing adaptor protein 2 like 1	Homo sapiens	38-43
20868675-5	2010	On the other hand, products of prolidase catalytic activity, proline (Pro) and hydroxyproline (HyPro) induced increase in the amount of TGF beta1 and TGF beta receptors.	Proline	61-68	transforming growth factor beta 1	Homo sapiens	136-145
20868675-5	2010	On the other hand, products of prolidase catalytic activity, proline (Pro) and hydroxyproline (HyPro) induced increase in the amount of TGF beta1 and TGF beta receptors.	Proline	61-68	transforming growth factor beta 1	Homo sapiens	136-144
20868675-5	2010	On the other hand, products of prolidase catalytic activity, proline (Pro) and hydroxyproline (HyPro) induced increase in the amount of TGF beta1 and TGF beta receptors.	Proline	70-73	transforming growth factor beta 1	Homo sapiens	136-145
20868675-5	2010	On the other hand, products of prolidase catalytic activity, proline (Pro) and hydroxyproline (HyPro) induced increase in the amount of TGF beta1 and TGF beta receptors.	Proline	70-73	transforming growth factor beta 1	Homo sapiens	136-144
20929444-4	2010	Our results demonstrate that an intramolecular interaction between Patch 2 in the Bro1 domain and the TSG101 (tumour susceptibility gene 101 protein)-docking site in the proline-rich domain locks ALIX into a closed conformation that renders ALIX unable to interact with CHMP4 and retroviral Gag proteins.	Proline	170-177	tumor susceptibility 101	Homo sapiens	102-108
20929444-4	2010	Our results demonstrate that an intramolecular interaction between Patch 2 in the Bro1 domain and the TSG101 (tumour susceptibility gene 101 protein)-docking site in the proline-rich domain locks ALIX into a closed conformation that renders ALIX unable to interact with CHMP4 and retroviral Gag proteins.	Proline	170-177	tumor susceptibility 101	Homo sapiens	110-148
20929444-4	2010	Our results demonstrate that an intramolecular interaction between Patch 2 in the Bro1 domain and the TSG101 (tumour susceptibility gene 101 protein)-docking site in the proline-rich domain locks ALIX into a closed conformation that renders ALIX unable to interact with CHMP4 and retroviral Gag proteins.	Proline	170-177	programmed cell death 6 interacting protein	Homo sapiens	196-200
20929444-4	2010	Our results demonstrate that an intramolecular interaction between Patch 2 in the Bro1 domain and the TSG101 (tumour susceptibility gene 101 protein)-docking site in the proline-rich domain locks ALIX into a closed conformation that renders ALIX unable to interact with CHMP4 and retroviral Gag proteins.	Proline	170-177	programmed cell death 6 interacting protein	Homo sapiens	241-245
20929444-4	2010	Our results demonstrate that an intramolecular interaction between Patch 2 in the Bro1 domain and the TSG101 (tumour susceptibility gene 101 protein)-docking site in the proline-rich domain locks ALIX into a closed conformation that renders ALIX unable to interact with CHMP4 and retroviral Gag proteins.	Proline	170-177	charged multivesicular body protein 4A	Homo sapiens	270-275
21179510-5	2010	We also discovered that the central proline-rich and histidine-rich domain of HD-PTP is responsible for these interactions.	Proline	36-43	protein tyrosine phosphatase non-receptor type 23	Homo sapiens	78-84
20805362-2	2010	Trib2 has 3 distinct regions, a proline-rich N-terminus, a serine/threonine kinase homology domain, and a C-terminal constitutive photomorphogenesis 1 (COP1)-binding domain.	Proline	32-39	tribbles pseudokinase 2	Homo sapiens	0-5
21084637-4	2010	Although a third domain, the proline-, serine- and threonine-enriched activation (PST) domain, in the C termini of all Pax-6 isoforms mediates their transcriptional modulation via phosphorylation, how p32 Pax-6 could regulate target genes remains to be elucidated.	Proline	29-36	paired box 6	Homo sapiens	119-124
21084637-4	2010	Although a third domain, the proline-, serine- and threonine-enriched activation (PST) domain, in the C termini of all Pax-6 isoforms mediates their transcriptional modulation via phosphorylation, how p32 Pax-6 could regulate target genes remains to be elucidated.	Proline	29-36	complement C1q binding protein	Homo sapiens	201-204
21084637-4	2010	Although a third domain, the proline-, serine- and threonine-enriched activation (PST) domain, in the C termini of all Pax-6 isoforms mediates their transcriptional modulation via phosphorylation, how p32 Pax-6 could regulate target genes remains to be elucidated.	Proline	29-36	paired box 6	Homo sapiens	205-210
20833277-8	2010	The enhanced stability of dN-GAPDS is likely to be related to some specific features of the GAPDS structure compared to that of the muscle enzyme: 1) reduced number of solvent-exposed salt bridges; 2) 2 additional buried salt bridges; and 3) 6 additional proline residues in GAPDS meeting the "proline rule".	Proline	255-262	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	29-34
20833277-8	2010	The enhanced stability of dN-GAPDS is likely to be related to some specific features of the GAPDS structure compared to that of the muscle enzyme: 1) reduced number of solvent-exposed salt bridges; 2) 2 additional buried salt bridges; and 3) 6 additional proline residues in GAPDS meeting the "proline rule".	Proline	255-262	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	92-97
20833277-8	2010	The enhanced stability of dN-GAPDS is likely to be related to some specific features of the GAPDS structure compared to that of the muscle enzyme: 1) reduced number of solvent-exposed salt bridges; 2) 2 additional buried salt bridges; and 3) 6 additional proline residues in GAPDS meeting the "proline rule".	Proline	294-301	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	92-97
20833277-8	2010	The enhanced stability of dN-GAPDS is likely to be related to some specific features of the GAPDS structure compared to that of the muscle enzyme: 1) reduced number of solvent-exposed salt bridges; 2) 2 additional buried salt bridges; and 3) 6 additional proline residues in GAPDS meeting the "proline rule".	Proline	255-262	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	92-97
20833277-8	2010	The enhanced stability of dN-GAPDS is likely to be related to some specific features of the GAPDS structure compared to that of the muscle enzyme: 1) reduced number of solvent-exposed salt bridges; 2) 2 additional buried salt bridges; and 3) 6 additional proline residues in GAPDS meeting the "proline rule".	Proline	294-301	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	29-34
20833277-8	2010	The enhanced stability of dN-GAPDS is likely to be related to some specific features of the GAPDS structure compared to that of the muscle enzyme: 1) reduced number of solvent-exposed salt bridges; 2) 2 additional buried salt bridges; and 3) 6 additional proline residues in GAPDS meeting the "proline rule".	Proline	294-301	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	92-97
20851206-4	2010	The orange-spotted grouper Sox11a contained the signature features of mammalian SOX11 homologues except the Pro-Glu rich region, was clustered with Sox11a homologues of other teleosts in the phylogenetic tree, and shared higher homologies with Sox11 of other species than the duplicated copy Sox11b.	Proline	108-111	SRY-box transcription factor 11	Homo sapiens	27-32
20919753-8	2010	The docking studies show binding of BH3 domain at Lys 110, Trp-111, Pro-115, Glu-119 and Asp-127 in the groove of BH 1, 2 and 3 domains of Bcl-2L10.	Proline	68-71	BCL2 like 10	Homo sapiens	139-147
23675206-1	2010	Functioning as an extracellular protease, dipeptidyl peptidase IV (DPP-IV) preferentially cleaves the peptide bond after the penultimate proline residue.	Proline	137-144	dipeptidyl peptidase 4	Homo sapiens	42-65
23675206-1	2010	Functioning as an extracellular protease, dipeptidyl peptidase IV (DPP-IV) preferentially cleaves the peptide bond after the penultimate proline residue.	Proline	137-144	dipeptidyl peptidase 4	Homo sapiens	67-73
20798394-9	2010	The majority of pSer/pThr have adjacent proline (Pro) residues and we show endogenous p38 mitogen activated protein kinase (MAPK) associated with and phosphorylated tensin1 in an in vitro kinase assay.	Proline	40-47	tensin 1	Homo sapiens	165-172
21044075-1	2010	Cyclin-dependent kinase (Cdk)5 is a proline-directed Ser/Thr protein kinase that functions mainly in neurons and is activated by binding to a regulatory subunit, p35 or p39.	Proline	36-43	cyclin dependent kinase 5	Homo sapiens	0-30
21044075-1	2010	Cyclin-dependent kinase (Cdk)5 is a proline-directed Ser/Thr protein kinase that functions mainly in neurons and is activated by binding to a regulatory subunit, p35 or p39.	Proline	36-43	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	162-165
21044075-1	2010	Cyclin-dependent kinase (Cdk)5 is a proline-directed Ser/Thr protein kinase that functions mainly in neurons and is activated by binding to a regulatory subunit, p35 or p39.	Proline	36-43	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	169-172
20798394-9	2010	The majority of pSer/pThr have adjacent proline (Pro) residues and we show endogenous p38 mitogen activated protein kinase (MAPK) associated with and phosphorylated tensin1 in an in vitro kinase assay.	Proline	49-52	tensin 1	Homo sapiens	165-172
21049971-6	2010	Using NMR spectroscopy, we have determined the structure of a complex of human Poliota UBM2 and ubiquitin, revealing a novel ubiquitin recognition fold consisting of two alpha-helices separated by a central trans-proline residue conserved in all UBMs.	Proline	213-220	UVM2	Homo sapiens	87-91
20870300-5	2010	Importantly, the minor binding pocket, especially the proline-kink in TM-II, is involved in G protein versus arrestin pathway-biased signaling, for example in the angiotensin AT1 system.	Proline	54-61	angiotensin II receptor type 1	Homo sapiens	175-178
20943816-7	2010	2) An increase in the neutral amino acid proline in the urine of Hnf1a-null mice correlated with loss of renal apical membrane transporters of the Slc6a family.	Proline	41-48	HNF1 homeobox A	Mus musculus	65-70
20858712-4	2010	SNP1 (rs35235055) results in a leucine-to-proline substitution (Leu(23)Pro), while SNP2 (rs35623192) results in an arginine-to-cysteine substitution (Arg(340)Cys).	Proline	42-49	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	0-4
20837482-9	2010	Functional assays revealed only two residues in the region of Pro(868)-Leu(967) (a functionally important region in AE1) that are highly sensitive to cysteine substitution.	Proline	62-65	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	116-119
21047126-2	2010	The angiotensin II metabolite angiotensin IV (Ang IV, Val(1)-Tyr(2)-Ile(3)-His(4)-Pro(5)-Phe(6)) binds with high affinity to IRAP and inhibits this aminopeptidase (K(i) = 62.4 nM).	Proline	82-85	leucyl and cystinyl aminopeptidase	Homo sapiens	125-129
20971063-5	2010	ADAM28 cleaved CTGF in dose- and time-dependent manners at the Ala(181)-Tyr(182) and Asp(191)-Pro(192) bonds in the hinge region of the molecule.	Proline	94-97	ADAM metallopeptidase domain 28	Homo sapiens	0-6
20971063-5	2010	ADAM28 cleaved CTGF in dose- and time-dependent manners at the Ala(181)-Tyr(182) and Asp(191)-Pro(192) bonds in the hinge region of the molecule.	Proline	94-97	cellular communication network factor 2	Homo sapiens	15-19
20977208-1	2010	The octapeptide angiotensin II (Ang II; Asp(1)-Arg(2)-Val(3)-Tyr(4)-Ile(5)-His(6)-Pro(7)-Phe(8)) is the primary active hormone of the renin/angiotensin system (RAS) and has been implicated in various cardiovascular diseases.	Proline	82-85	angiotensinogen	Homo sapiens	16-30
20946873-2	2010	Recent solution NMR structural studies have shown that a proline-rich peptide is capable of binding to the human vinexin SH3 domain.	Proline	57-64	sorbin and SH3 domain containing 3	Homo sapiens	113-120
20932746-2	2010	Pin1 isomerizes bonds linking phospho-serine/threonine moieties to proline enabling it to play a key role in proline-directed kinase signalling.	Proline	67-74	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
20932746-2	2010	Pin1 isomerizes bonds linking phospho-serine/threonine moieties to proline enabling it to play a key role in proline-directed kinase signalling.	Proline	109-116	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
20837474-6	2010	In this study, we demonstrate that Rv1917c (PPE34), a representative member of the proline-proline-glutamic-major polymorphic tandem repeat family, interacts with TLR2 and triggers functional maturation of human DCs.	Proline	83-90	toll like receptor 2	Homo sapiens	163-167
20837474-6	2010	In this study, we demonstrate that Rv1917c (PPE34), a representative member of the proline-proline-glutamic-major polymorphic tandem repeat family, interacts with TLR2 and triggers functional maturation of human DCs.	Proline	91-98	toll like receptor 2	Homo sapiens	163-167
20977208-1	2010	The octapeptide angiotensin II (Ang II; Asp(1)-Arg(2)-Val(3)-Tyr(4)-Ile(5)-His(6)-Pro(7)-Phe(8)) is the primary active hormone of the renin/angiotensin system (RAS) and has been implicated in various cardiovascular diseases.	Proline	82-85	angiogenin	Homo sapiens	32-35
20977208-1	2010	The octapeptide angiotensin II (Ang II; Asp(1)-Arg(2)-Val(3)-Tyr(4)-Ile(5)-His(6)-Pro(7)-Phe(8)) is the primary active hormone of the renin/angiotensin system (RAS) and has been implicated in various cardiovascular diseases.	Proline	82-85	renin	Homo sapiens	134-139
20801878-4	2010	The 1.7 A crystal structure of cyclophilin with the proline-rich P-domain of calmegin reveals that binding is mediated by the same surface that binds ERp57.	Proline	52-59	calmegin	Homo sapiens	77-85
20837638-0	2010	Rapid desensitization of the rat alpha7 nAChR is facilitated by the presence of a proline residue in the outer beta-sheet.	Proline	82-89	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	40-45
20837638-1	2010	The rat alpha7 nicotinic acetylcholine receptor (nAChR) has a proline residue near the middle of the beta9 strand.	Proline	62-69	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	49-54
20837638-10	2010	Our results indicate that rapid desensitization of the wild-type rat alpha7 nAChR is facilitated by the presence of the proline residue within the beta9 strand.	Proline	120-127	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	76-81
20801878-4	2010	The 1.7 A crystal structure of cyclophilin with the proline-rich P-domain of calmegin reveals that binding is mediated by the same surface that binds ERp57.	Proline	52-59	protein disulfide isomerase family A member 3	Homo sapiens	150-155
20805222-7	2010	Inserting Pro(510)-Tyr(511) eliminated N-glycan polysialylation and enhanced O-glycosylation of an NCAM- olfactory cell adhesion molecule chimera, and inserting other FN1 sequences unique to NCAM, predominantly the acidic patch, created a new polysialyltransferase recognition site.	Proline	10-13	neural cell adhesion molecule 1	Homo sapiens	99-103
20946875-6	2010	Both interactions are mediated by the SH3 domains of ITSN1 and proline-rich motifs of protein partners.	Proline	63-70	intersectin 1	Homo sapiens	53-58
20801874-1	2010	Reversible proline-directed phosphorylation at Ser/Thr-Pro motifs has an essential role in myogenesis, a multistep process strictly regulated by several signaling pathways that impinge on two families of myogenic effectors, the basic helix-loop-helix myogenic transcription factors and the MEF2 (myocyte enhancer factor 2) proteins.	Proline	11-18	myocyte enhancer factor 2C	Mus musculus	290-294
20805222-7	2010	Inserting Pro(510)-Tyr(511) eliminated N-glycan polysialylation and enhanced O-glycosylation of an NCAM- olfactory cell adhesion molecule chimera, and inserting other FN1 sequences unique to NCAM, predominantly the acidic patch, created a new polysialyltransferase recognition site.	Proline	10-13	neural cell adhesion molecule 1	Homo sapiens	191-195
20801874-1	2010	Reversible proline-directed phosphorylation at Ser/Thr-Pro motifs has an essential role in myogenesis, a multistep process strictly regulated by several signaling pathways that impinge on two families of myogenic effectors, the basic helix-loop-helix myogenic transcription factors and the MEF2 (myocyte enhancer factor 2) proteins.	Proline	11-18	myocyte enhancer factor 2C	Mus musculus	296-321
20624930-8	2010	Our data provide the direct evidence that NF-M/H are hyperphosphorylated in AD compared with control brain and suggest the role of both proline-directed and non-proline-directed protein kinases in AD.	Proline	136-143	neurofilament medium chain	Homo sapiens	42-48
20801874-6	2010	The interaction with Pin1 requires two novel critical phospho-Ser/Thr-Pro motifs in MEF2C, Ser(98) and Ser(110), which are phosphorylated in vivo.	Proline	70-73	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	21-25
20801874-6	2010	The interaction with Pin1 requires two novel critical phospho-Ser/Thr-Pro motifs in MEF2C, Ser(98) and Ser(110), which are phosphorylated in vivo.	Proline	70-73	myocyte enhancer factor 2C	Mus musculus	84-89
20805222-4	2010	Here, we characterize the contribution of two additional FN1 sequences, Pro(510)-Tyr(511)-Ser(512) (PYS) and Gln(516)-Val(517)-Gln(518) (QVQ).	Proline	72-75	fibronectin 1	Homo sapiens	57-60
20828147-0	2010	The conformation and the aggregation kinetics of alpha-synuclein depend on the proline residues in its C-terminal region.	Proline	79-86	synuclein alpha	Homo sapiens	49-64
20828147-3	2010	The C-terminal domain of alpha-syn is characterized by the presence of 15 acidic amino acids and all five proline residues of the protein (P108, P117, P120, P128, and P138).	Proline	106-113	synuclein alpha	Homo sapiens	25-34
20828147-7	2010	To further elucidate the role of the proline residues in the conformation and aggregation of alpha-syn, we constructed several mutants of alpha-syn in which one or more proline residues are mutated to alanine via site-directed mutagenesis.	Proline	37-44	synuclein alpha	Homo sapiens	93-102
20508646-5	2010	Furthermore, we ascertained that JIP1 caused the cytoplasmic retention of RBP-Jk through an interaction between the C-terminal region of JIP1 including Src homology 3 domain and the proline-rich domain of RBP-Jk.	Proline	182-189	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	33-37
20508646-5	2010	Furthermore, we ascertained that JIP1 caused the cytoplasmic retention of RBP-Jk through an interaction between the C-terminal region of JIP1 including Src homology 3 domain and the proline-rich domain of RBP-Jk.	Proline	182-189	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	74-80
20508646-5	2010	Furthermore, we ascertained that JIP1 caused the cytoplasmic retention of RBP-Jk through an interaction between the C-terminal region of JIP1 including Src homology 3 domain and the proline-rich domain of RBP-Jk.	Proline	182-189	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	205-211
20978146-1	2010	PURPOSE: We have previously shown that von Hippel-Lindau (VHL) regulates ubiquitylation and proline 1465 hydroxylation of the large subunit of RNA polymerase II, Rpb1, in human renal clear cell carcinoma (RCC) cell lines.	Proline	92-99	von Hippel-Lindau tumor suppressor	Homo sapiens	39-56
20978146-1	2010	PURPOSE: We have previously shown that von Hippel-Lindau (VHL) regulates ubiquitylation and proline 1465 hydroxylation of the large subunit of RNA polymerase II, Rpb1, in human renal clear cell carcinoma (RCC) cell lines.	Proline	92-99	RNA polymerase II subunit A	Homo sapiens	162-166
20624930-2	2010	Human NF-M/H display a large number of multiple KSP repeats in the carboxy-terminal tail domain, which are phosphorylation sites of proline-directed serine/threonine (pSer/Thr-Pro, KS/T-P) kinases.	Proline	132-139	neurofilament medium chain	Homo sapiens	6-10
20624930-5	2010	We identified 13 hyperphosphorylated sites of NF-M; 9 Lys-Ser-Pro (KSP) sites; 2 variant motifs, Glu-Ser-Pro (ESP) Ser-736 and Leu-Ser-Pro (LSP) Ser-837; and 2 non-S/T-P motifs, Ser-783 and Ser-788.	Proline	105-108	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	110-113
20624930-5	2010	We identified 13 hyperphosphorylated sites of NF-M; 9 Lys-Ser-Pro (KSP) sites; 2 variant motifs, Glu-Ser-Pro (ESP) Ser-736 and Leu-Ser-Pro (LSP) Ser-837; and 2 non-S/T-P motifs, Ser-783 and Ser-788.	Proline	105-108	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	110-113
20828147-10	2010	We can conclude that mutation of the proline residues to alanine accelerates the aggregation kinetics of alpha-syn while all proline mutants formed fibrils similar to His-WT alpha-syn, as visualized via transmission electron microscopy.	Proline	37-44	synuclein alpha	Homo sapiens	105-114
20828147-11	2010	We also demonstrate that the accelerating effect of hFKBP12 is abolished via removal of the proline residues from the C-terminus.	Proline	92-99	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	52-59
20828147-12	2010	Finally, we show that the mutant of His alpha-syn with all five proline residues mutated to alanine is more structured (more alpha-helix) than His-WT alpha-syn, indicating the role of the Pro residues as potential helix breakers in the inhibitory conformation of the C-terminus.	Proline	64-71	synuclein alpha	Homo sapiens	40-49
21035851-5	2010	Here we show that substituting the equivalent location in TRPV5, the M490, to proline significantly modulates Ca(2+)-dependent inactivation of TRPV5.	Proline	78-85	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	58-63
21035851-5	2010	Here we show that substituting the equivalent location in TRPV5, the M490, to proline significantly modulates Ca(2+)-dependent inactivation of TRPV5.	Proline	78-85	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	143-148
20634350-4	2010	By combining molecular and biophysical (surface plasmon resonance, NMR, and fluorescence resonance energy transfer) approaches, we demonstrated that the third SH3 domain of vinexinbeta interacts with a proline-rich domain (PRD) located in RARgamma NTD and that phosphorylation at a serine located in the PRD abrogates the interaction.	Proline	202-209	retinoic acid receptor gamma	Homo sapiens	239-247
20972335-4	2010	Oxygen-dependent changes in HIF-1alpha levels are regulated by proline hydroxylation and proteasomal degradation.	Proline	63-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
20696156-7	2010	Deletion of a cluster of proline-rich motifs in the C-terminus of bestrophin-1 reduced its co-immuno precipitation with the beta4-subunit and strongly reduced the Ca(V)1.3 activity.	Proline	25-32	bestrophin 1	Homo sapiens	66-78
20351748-7	2010	The ATPase-binding domain lies within the proline/serine/threonine-rich region of CIITA and encompasses a majority of the CIITA degron sequence.	Proline	42-49	class II major histocompatibility complex transactivator	Homo sapiens	82-87
20351748-7	2010	The ATPase-binding domain lies within the proline/serine/threonine-rich region of CIITA and encompasses a majority of the CIITA degron sequence.	Proline	42-49	class II major histocompatibility complex transactivator	Homo sapiens	122-127
20889493-0	2010	Proline-rich domain in dynamin-2 has a low microtubule-binding activity: how is this activity controlled during mitosis in HeLa cells?	Proline	0-7	dynamin 2	Homo sapiens	23-32
20696156-7	2010	Deletion of a cluster of proline-rich motifs in the C-terminus of bestrophin-1 reduced its co-immuno precipitation with the beta4-subunit and strongly reduced the Ca(V)1.3 activity.	Proline	25-32	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	163-171
20512787-5	2010	Glutamine, leucine and proline all reduced NF-kappaB activity after 3 h of IL-1beta stimulation at 2, 5 and 10 mM (p&lt;0.001).	Proline	23-30	nuclear factor kappa B subunit 1	Homo sapiens	43-52
20696156-8	2010	Cells co-expressing bestrophin-1 lacking the proline-rich motifs and Ca(V)1.3 subunits showed less efficient trafficking of bestrophin-1 into the cell membrane.	Proline	45-52	bestrophin 1	Homo sapiens	20-32
20696156-9	2010	In summary, we conclude that bestrophin-1 modulates L-type channels of the RPE via proline-rich motif-dependent interaction with beta4-subunits.	Proline	83-90	bestrophin 1	Homo sapiens	29-41
20512787-5	2010	Glutamine, leucine and proline all reduced NF-kappaB activity after 3 h of IL-1beta stimulation at 2, 5 and 10 mM (p&lt;0.001).	Proline	23-30	interleukin 1 beta	Homo sapiens	75-83
20512787-6	2010	Insulin-induced (1 nM) Akt phosphorylation was reduced in cells treated with tumour necrosis factor-alpha (10 ng/mL) for 24 h, but was partly restored by simultaneous incubation with glutamine, leucine and proline (25 mM).	Proline	206-213	AKT serine/threonine kinase 1	Homo sapiens	23-26
20512787-8	2010	Our results indicate that glutamine, leucine and proline attenuate IL-8 production, probably through inhibition of NF-kappaB, and that they increase Akt phosphorylation in HepG2 cells.	Proline	49-56	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
20512787-8	2010	Our results indicate that glutamine, leucine and proline attenuate IL-8 production, probably through inhibition of NF-kappaB, and that they increase Akt phosphorylation in HepG2 cells.	Proline	49-56	nuclear factor kappa B subunit 1	Homo sapiens	115-124
20972448-4	2010	The different Phi spacings are compensated for by different conformations of the bound NESs: in the case of PKI, an alpha-helical conformation, and in the case of Rev, an extended conformation with a critical proline docking into a Phi pocket.	Proline	209-216	Rev	Human immunodeficiency virus 1	163-166
21384570-2	2010	The p53 gene is characterized by Arg/Pro polymorphism in codon 72 whose alleles exhibit differential functional activity.	Proline	37-40	tumor protein p53	Homo sapiens	4-7
20675722-2	2010	We have shown previously that the Proline-Rich Homeodomain protein (PRH/Hex) self-assembles to form oligomeric complexes that bind to arrays of PRH binding sites with high affinity and specificity.	Proline	34-41	hematopoietically expressed homeobox	Homo sapiens	68-71
20675722-2	2010	We have shown previously that the Proline-Rich Homeodomain protein (PRH/Hex) self-assembles to form oligomeric complexes that bind to arrays of PRH binding sites with high affinity and specificity.	Proline	34-41	hematopoietically expressed homeobox	Homo sapiens	72-75
20675722-2	2010	We have shown previously that the Proline-Rich Homeodomain protein (PRH/Hex) self-assembles to form oligomeric complexes that bind to arrays of PRH binding sites with high affinity and specificity.	Proline	34-41	hematopoietically expressed homeobox	Homo sapiens	144-147
20545884-1	2010	Proline accumulation in response to abiotic stress is controlled partially by transcriptional regulation of key enzymes including Delta1-pyrroline-carboxylate synthetase1 (P5CS1), proline dehydrogenase (ProDH), ornithine amino transferase (OAT) and Delta1-pyrroline-carboxylate dehydrogenase (P5CDH).	Proline	0-7	proline dehydrogenase 1	Homo sapiens	180-201
20545884-1	2010	Proline accumulation in response to abiotic stress is controlled partially by transcriptional regulation of key enzymes including Delta1-pyrroline-carboxylate synthetase1 (P5CS1), proline dehydrogenase (ProDH), ornithine amino transferase (OAT) and Delta1-pyrroline-carboxylate dehydrogenase (P5CDH).	Proline	0-7	proline dehydrogenase 1	Homo sapiens	203-208
20545884-1	2010	Proline accumulation in response to abiotic stress is controlled partially by transcriptional regulation of key enzymes including Delta1-pyrroline-carboxylate synthetase1 (P5CS1), proline dehydrogenase (ProDH), ornithine amino transferase (OAT) and Delta1-pyrroline-carboxylate dehydrogenase (P5CDH).	Proline	0-7	ornithine aminotransferase	Homo sapiens	211-238
20545884-1	2010	Proline accumulation in response to abiotic stress is controlled partially by transcriptional regulation of key enzymes including Delta1-pyrroline-carboxylate synthetase1 (P5CS1), proline dehydrogenase (ProDH), ornithine amino transferase (OAT) and Delta1-pyrroline-carboxylate dehydrogenase (P5CDH).	Proline	0-7	aldehyde dehydrogenase 4 family member A1	Homo sapiens	293-298
20545884-5	2010	ProDH downregulation by low water potential and upregulation by stress release was not impaired in aba2-1, p5cs1 or p5cs1/aba2-1 compared with wild type despite differing ABA and proline levels in these mutants.	Proline	179-186	proline dehydrogenase 1	Homo sapiens	0-5
20724472-4	2010	Proline-directed phosphorylation acted additively to regulate multiple aspects of ATF4 degradation.	Proline	0-7	activating transcription factor 4	Homo sapiens	82-86
20675384-1	2010	Pin1 is a unique regulator, which catalyzes the conversion of a specific phospho-Ser/Thr-Pro-containing motif in target proteins.	Proline	89-92	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
20967267-7	2010	E-PE tissues had markedly diminished HIF-1alpha hydroxylation at proline residues 402 and 564 as assessed with monoclonal antibodies raised against hydroxylated HIF-1alpha P402 or P564, suggesting regulation by PHD2 and not PHD3.	Proline	65-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
20729193-0	2010	The role of proline in the membrane re-entrant helix of caveolin-1.	Proline	12-19	caveolin 1	Homo sapiens	56-66
20729193-12	2010	Thus, the single Pro residue in the membrane-inserting segment of caveolin-1 plays an important role in both the membrane topology and localization of the protein as well as its functions.	Proline	17-20	caveolin 1	Homo sapiens	66-76
20427142-1	2010	A common polymorphism at codon 72 of human TP53 gene determines a proline to arginine aminoacidic substitution within the proline-rich domain of p53 protein.	Proline	66-73	tumor protein p53	Homo sapiens	43-47
20682773-0	2010	Prolyl isomerase Pin1 regulates transcription factor LSF (TFCP2) by facilitating dephosphorylation at two serine-proline motifs.	Proline	113-120	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	17-21
20427142-1	2010	A common polymorphism at codon 72 of human TP53 gene determines a proline to arginine aminoacidic substitution within the proline-rich domain of p53 protein.	Proline	66-73	tumor protein p53	Homo sapiens	145-148
20427142-1	2010	A common polymorphism at codon 72 of human TP53 gene determines a proline to arginine aminoacidic substitution within the proline-rich domain of p53 protein.	Proline	122-129	tumor protein p53	Homo sapiens	43-47
20427142-1	2010	A common polymorphism at codon 72 of human TP53 gene determines a proline to arginine aminoacidic substitution within the proline-rich domain of p53 protein.	Proline	122-129	tumor protein p53	Homo sapiens	145-148
20675386-2	2010	HIF-1alpha protein accumulates in hypoxia due to inhibition of prolyl hydroxylase enzymes, which under normoxic conditions use molecular oxygen to hydroxylate HIF-1alpha on two conserved proline residues (Pro(402) and Pro(564)), thus targeting the protein for 26 S proteasome-dependent degradation.	Proline	187-194	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
20675386-2	2010	HIF-1alpha protein accumulates in hypoxia due to inhibition of prolyl hydroxylase enzymes, which under normoxic conditions use molecular oxygen to hydroxylate HIF-1alpha on two conserved proline residues (Pro(402) and Pro(564)), thus targeting the protein for 26 S proteasome-dependent degradation.	Proline	187-194	hypoxia inducible factor 1 subunit alpha	Homo sapiens	159-169
20675386-2	2010	HIF-1alpha protein accumulates in hypoxia due to inhibition of prolyl hydroxylase enzymes, which under normoxic conditions use molecular oxygen to hydroxylate HIF-1alpha on two conserved proline residues (Pro(402) and Pro(564)), thus targeting the protein for 26 S proteasome-dependent degradation.	Proline	205-208	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
20675386-2	2010	HIF-1alpha protein accumulates in hypoxia due to inhibition of prolyl hydroxylase enzymes, which under normoxic conditions use molecular oxygen to hydroxylate HIF-1alpha on two conserved proline residues (Pro(402) and Pro(564)), thus targeting the protein for 26 S proteasome-dependent degradation.	Proline	205-208	hypoxia inducible factor 1 subunit alpha	Homo sapiens	159-169
20675386-2	2010	HIF-1alpha protein accumulates in hypoxia due to inhibition of prolyl hydroxylase enzymes, which under normoxic conditions use molecular oxygen to hydroxylate HIF-1alpha on two conserved proline residues (Pro(402) and Pro(564)), thus targeting the protein for 26 S proteasome-dependent degradation.	Proline	218-221	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
20675386-2	2010	HIF-1alpha protein accumulates in hypoxia due to inhibition of prolyl hydroxylase enzymes, which under normoxic conditions use molecular oxygen to hydroxylate HIF-1alpha on two conserved proline residues (Pro(402) and Pro(564)), thus targeting the protein for 26 S proteasome-dependent degradation.	Proline	218-221	hypoxia inducible factor 1 subunit alpha	Homo sapiens	159-169
20682773-0	2010	Prolyl isomerase Pin1 regulates transcription factor LSF (TFCP2) by facilitating dephosphorylation at two serine-proline motifs.	Proline	113-120	transcription factor CP2	Homo sapiens	53-56
20682773-0	2010	Prolyl isomerase Pin1 regulates transcription factor LSF (TFCP2) by facilitating dephosphorylation at two serine-proline motifs.	Proline	113-120	transcription factor CP2	Homo sapiens	58-63
20920334-5	2010	NMR data at atomic resolution indicate prolyl cis/trans isomerisation of the highly conserved proline residues Pro-5, -10, -14 and -35 of Vpr are catalyzed by human CypA and require only very low concentrations of the isomerase relative to that of the peptide substrates.	Proline	94-101	peptidylprolyl isomerase A	Homo sapiens	165-169
20920334-5	2010	NMR data at atomic resolution indicate prolyl cis/trans isomerisation of the highly conserved proline residues Pro-5, -10, -14 and -35 of Vpr are catalyzed by human CypA and require only very low concentrations of the isomerase relative to that of the peptide substrates.	Proline	111-114	peptidylprolyl isomerase A	Homo sapiens	165-169
20920334-8	2010	CONCLUSIONS: Only N-terminal peptides of Vpr containing Pro-35, which appears to be vital for manifold functions of Vpr, bind to CypA in a biosensor assay.	Proline	56-59	peptidylprolyl isomerase A	Homo sapiens	129-133
20920334-9	2010	This indicates that Pro-35 is essential for a specific CypA-Vpr binding interaction, in contrast to the general prolyl cis/trans isomerisation observed for all proline residues of Vpr, which only involve transient enzyme-substrate interactions.	Proline	20-23	peptidylprolyl isomerase A	Homo sapiens	55-59
20482929-0	2010	The casein peptide Asn-Pro-Trp-Asp-Gln enforces the intestinal tight junction partly by increasing occludin expression in Caco-2 cells.	Proline	23-26	occludin	Homo sapiens	99-107
20921992-3	2010	We investigated the effect on Mcl-1 function of mutation at a conserved threonine 163 residue (T163) in its proline, glutamate, serine, and threonine rich (PEST) region.	Proline	108-115	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	30-35
20670214-6	2010	Through biophysical experiments, we then identified the PRR (proline-rich region) motif of Alix that binds Hck-SH3 and determined a dissociation constant of 34.5 muM.	Proline	61-68	programmed cell death 6 interacting protein	Homo sapiens	91-95
20670214-6	2010	Through biophysical experiments, we then identified the PRR (proline-rich region) motif of Alix that binds Hck-SH3 and determined a dissociation constant of 34.5 muM.	Proline	61-68	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	107-110
20673832-10	2010	Plasmodium might require a tight Trx-mediated control of OAT activity for coordinating ornithine homeostasis, polyamine synthesis, proline synthesis, and mitotic cell division.	Proline	131-138	thioredoxin	Homo sapiens	33-36
20600704-1	2010	Prolyl oligopeptidase (POP) is a widely distributed serine peptidase which hydrolyzes small peptides on the carboxyl side of an internal proline residue.	Proline	137-144	prolyl endopeptidase	Mus musculus	0-21
20600704-1	2010	Prolyl oligopeptidase (POP) is a widely distributed serine peptidase which hydrolyzes small peptides on the carboxyl side of an internal proline residue.	Proline	137-144	prolyl endopeptidase	Mus musculus	23-26
20861372-8	2010	Together with evidence in mammalian systems, our findings implicate proline-directed kinases in clock mechanisms and suggest that PER proteins are key downstream targets of lithium therapy, a potent inhibitor of GSK-3beta used to treat manic depression, a disorder associated with clock malfunction in humans.	Proline	68-75	glycogen synthase kinase 3 beta	Homo sapiens	212-221
20643654-5	2010	A proline-rich sequence in PDK1 bound to an Src homology 3 domain in Grb2 in response to IGF-I.	Proline	2-9	growth factor receptor bound protein 2	Homo sapiens	69-73
20880398-5	2010	SLC36A1-mediated L-[3H]Pro uptake in Caco-2 cells was measured in the absence and presence of Gly-Gly or Gly-Sar.	Proline	23-26	solute carrier family 36 member 1	Homo sapiens	0-7
20880398-7	2010	KEY RESULTS In SLC36A1-expressing oocytes, an inward current was induced by Gly-Sar, Gly-Gly, delta-aminolevulinic acid, beta-aminoethylglycine, delta-aminopentanoic acid, GABA, Gly and Pro, whereas Val, Leu, mannitol, 5-HTP and the dipeptides Gly-Ala, Gly-Pro and Gly-Phe did not evoke currents.	Proline	186-189	solute carrier family 36 member 1	Homo sapiens	15-22
20577877-1	2010	The TP53 tumor suppressor gene contains a well-studied polymorphism that encodes either proline (P) or arginine (R) at codon 72, and over half of the world"s population is homozygous for R at this codon.	Proline	88-95	tumor protein p53	Homo sapiens	4-8
20418180-4	2010	We found that DCLK-long but not DCLK-short is phosphorylated in its serine/proline-rich domain.	Proline	75-82	doublecortin like kinase 1	Homo sapiens	14-18
20836733-5	2010	Among GPCRs in general, the unusually proline-rich IL3 is unique to the D4 receptor (D4R).	Proline	38-45	interleukin 3	Homo sapiens	51-54
20836733-5	2010	Among GPCRs in general, the unusually proline-rich IL3 is unique to the D4 receptor (D4R).	Proline	38-45	dopamine receptor D4	Homo sapiens	72-83
20836733-5	2010	Among GPCRs in general, the unusually proline-rich IL3 is unique to the D4 receptor (D4R).	Proline	38-45	dopamine receptor D4	Homo sapiens	85-88
20927389-5	2010	We identify cyclophilin B (CyPB) as the ER-resident target of CsA that catalytically enhances disposal from the ER of ERAD-L(S) substrates containing cis proline residues.	Proline	154-161	peptidylprolyl isomerase B	Homo sapiens	12-25
20927389-5	2010	We identify cyclophilin B (CyPB) as the ER-resident target of CsA that catalytically enhances disposal from the ER of ERAD-L(S) substrates containing cis proline residues.	Proline	154-161	peptidylprolyl isomerase B	Homo sapiens	27-31
20886100-5	2010	Five independent selections revealed related mutations in a single dipeptide motif (D316 and Y317) located in a proline-rich region of NS5A domain II, which has been implicated in CyPA binding.	Proline	112-119	peptidylprolyl isomerase A	Homo sapiens	180-184
20886100-6	2010	Engineering the mutations into wild-type HCV fully recapitulated the CyPA-independent and CsA-resistant phenotype and four putative proline substrates of CyPA were mapped to the vicinity of the DY motif.	Proline	132-139	peptidylprolyl isomerase A	Homo sapiens	154-158
20643654-5	2010	A proline-rich sequence in PDK1 bound to an Src homology 3 domain in Grb2 in response to IGF-I.	Proline	2-9	pyruvate dehydrogenase kinase 1	Homo sapiens	27-31
20643654-5	2010	A proline-rich sequence in PDK1 bound to an Src homology 3 domain in Grb2 in response to IGF-I.	Proline	2-9	insulin like growth factor 1	Homo sapiens	89-94
20643654-6	2010	Disruption of Grb2-PDK1 by expression of either a Grb2 Src homology 3 domain or a PDK1 proline to alanine mutant inhibited PDK1 recruitment to SHPS-1, leading to impaired IGF-I-stimulated AKT Thr(308) phosphorylation.	Proline	87-94	growth factor receptor bound protein 2	Homo sapiens	14-18
20643654-6	2010	Disruption of Grb2-PDK1 by expression of either a Grb2 Src homology 3 domain or a PDK1 proline to alanine mutant inhibited PDK1 recruitment to SHPS-1, leading to impaired IGF-I-stimulated AKT Thr(308) phosphorylation.	Proline	87-94	pyruvate dehydrogenase kinase 1	Homo sapiens	19-23
20643654-6	2010	Disruption of Grb2-PDK1 by expression of either a Grb2 Src homology 3 domain or a PDK1 proline to alanine mutant inhibited PDK1 recruitment to SHPS-1, leading to impaired IGF-I-stimulated AKT Thr(308) phosphorylation.	Proline	87-94	pyruvate dehydrogenase kinase 1	Homo sapiens	82-86
20719320-3	2010	The BET model was found to be the best choice to describe the nonlinear behavior of proline adsorption under hydrophilic interaction chromatography conditions.	Proline	84-91	delta/notch like EGF repeat containing	Homo sapiens	4-7
20643654-6	2010	Disruption of Grb2-PDK1 by expression of either a Grb2 Src homology 3 domain or a PDK1 proline to alanine mutant inhibited PDK1 recruitment to SHPS-1, leading to impaired IGF-I-stimulated AKT Thr(308) phosphorylation.	Proline	87-94	pyruvate dehydrogenase kinase 1	Homo sapiens	82-86
20643654-6	2010	Disruption of Grb2-PDK1 by expression of either a Grb2 Src homology 3 domain or a PDK1 proline to alanine mutant inhibited PDK1 recruitment to SHPS-1, leading to impaired IGF-I-stimulated AKT Thr(308) phosphorylation.	Proline	87-94	signal regulatory protein alpha	Homo sapiens	143-149
20643654-6	2010	Disruption of Grb2-PDK1 by expression of either a Grb2 Src homology 3 domain or a PDK1 proline to alanine mutant inhibited PDK1 recruitment to SHPS-1, leading to impaired IGF-I-stimulated AKT Thr(308) phosphorylation.	Proline	87-94	insulin like growth factor 1	Homo sapiens	171-176
20702732-3	2010	Zebrafish Tirap lacks the phosphatidylinositol 4,5-bisphosphate binding motif required for human TIRAP location and has leucine at position 233 rather than the conserved proline of human TIRAP, as well as 105 additional aa at the N terminus.	Proline	170-177	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	Danio rerio	10-15
20736302-5	2010	The SH3 domain negatively regulates Slpr activity consistent with autoinhibition via a conserved proline motif.	Proline	97-104	slipper	Drosophila melanogaster	36-40
20702732-6	2010	The function of Myd88 was dependent on its cellular location and the proline in the Toll/IL-1R domain.	Proline	69-76	MYD88 innate immune signal transduction adaptor	Danio rerio	16-21
20825647-1	2010	BACKGROUND: We previously reported that cynomolgus monkey (CM) TRIM5alpha could restrict human immunodeficiency virus type 2 (HIV-2) strains carrying a proline at the 120th position of the capsid protein (CA), but it failed to restrict those with a glutamine or an alanine.	Proline	152-159	tripartite motif-containing protein 5	Macaca fascicularis	63-73
20825647-6	2010	A single glutamine-to-proline substitution at the 118th amino acid of SIVmac239 CA, corresponding to the 120th amino acid of HIV-2 GH123, also increased susceptibility to Rh TRIM5alpha, indicating that glutamine at the 118th of SIVmac239 CA is necessary to evade Rh TRIM5alpha.	Proline	22-29	tripartite motif containing 5	Macaca mulatta	174-184
20715791-5	2010	The N-terminal proline of PmMIF is critical for these reactions because the P1A mutant has strongly reduced tautomerase activities.	Proline	15-22	zinc finger protein 185 with LIM domain	Homo sapiens	76-79
20825647-6	2010	A single glutamine-to-proline substitution at the 118th amino acid of SIVmac239 CA, corresponding to the 120th amino acid of HIV-2 GH123, also increased susceptibility to Rh TRIM5alpha, indicating that glutamine at the 118th of SIVmac239 CA is necessary to evade Rh TRIM5alpha.	Proline	22-29	tripartite motif containing 5	Macaca mulatta	266-276
20732856-4	2010	We observed an increased risk of cervical cancer associated with the p53 Arg/Arg (OR, 2.25; 95% CI, 1.11-4.54) or p21 Ser/Ser (OR, 2.09; 95% CI, 1.04-4.19) genotype, compared with the p53 Pro/Pro or p21 Arg/Arg genotype, respectively.	Proline	188-191	tumor protein p53	Homo sapiens	69-72
20599558-4	2010	Interestingly, homozygous mice expressing a deletion mutant (the proline-rich domain deleted) of the p53 develop various types of spontaneous tumors, particularly of B cell origin upon aging.	Proline	65-72	transformation related protein 53, pseudogene	Mus musculus	101-104
20176004-2	2010	In neurons, the catalytic subunit of acetylcholinesterase (AChE(T)) interacts with proline-rich membrane anchor (PRiMA) to form a globular tetrameric form (G(4) form).	Proline	83-90	acetylcholinesterase	Mus musculus	37-57
20176004-2	2010	In neurons, the catalytic subunit of acetylcholinesterase (AChE(T)) interacts with proline-rich membrane anchor (PRiMA) to form a globular tetrameric form (G(4) form).	Proline	83-90	acetylcholinesterase	Mus musculus	59-66
20176004-2	2010	In neurons, the catalytic subunit of acetylcholinesterase (AChE(T)) interacts with proline-rich membrane anchor (PRiMA) to form a globular tetrameric form (G(4) form).	Proline	83-90	proline rich membrane anchor 1	Mus musculus	113-118
20178777-2	2010	The AChE(T) variant is expressed in the brain and muscle: this subunit forms non-amphiphilic tetramers with a collagen tail (ColQ) as asymmetric AChE (A(12) AChE) in muscle, and amphiphilic tetramers with a proline-rich membrane anchor (PRiMA) as globular AChE (G(4) AChE) in the brain and muscle.	Proline	207-214	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-8
20732856-4	2010	We observed an increased risk of cervical cancer associated with the p53 Arg/Arg (OR, 2.25; 95% CI, 1.11-4.54) or p21 Ser/Ser (OR, 2.09; 95% CI, 1.04-4.19) genotype, compared with the p53 Pro/Pro or p21 Arg/Arg genotype, respectively.	Proline	192-195	tumor protein p53	Homo sapiens	69-72
20109515-1	2010	Src kinase activity is regulated by the interaction of SH3 domain with protein sequences that are rich in proline residues.	Proline	106-113	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
20657603-3	2010	Here we report on a novel human RING finger protein, ZNF645, which contains a C3HC4 RING finger domain, a C2H2 zinc-finger domain, and a proline-rich region, indicating that it has a structure similar to that of the c-Cbl-like protein Hakai.	Proline	137-144	Cbl proto-oncogene like 2	Homo sapiens	53-59
20580912-5	2010	Par45 shows a strong preference for a substrate with the basic Arg residue preceding Pro (Suc-Ala-Arg-Pro-Phe-NH-Np: k(cat)/K(M)=97.1 /M/s), like that found for human Par14.	Proline	102-105	peptidylprolyl cis/trans isomerase, NIMA-interacting 4	Homo sapiens	167-172
20304108-5	2010	The major difference between the (1)H-(15)N HSQC spectra of rp(H)M180 and rp(H)LRAP was an additional set of amide resonances for each of the seven non-proline residues between S12 and Y12 near the N-terminus of rp(H)LRAP indicating that the N-terminal region of LRAP exists in two different conformations.	Proline	152-159	amelogenin, X-linked	Mus musculus	74-83
20304108-5	2010	The major difference between the (1)H-(15)N HSQC spectra of rp(H)M180 and rp(H)LRAP was an additional set of amide resonances for each of the seven non-proline residues between S12 and Y12 near the N-terminus of rp(H)LRAP indicating that the N-terminal region of LRAP exists in two different conformations.	Proline	152-159	amelogenin, X-linked	Mus musculus	79-83
20656895-6	2010	Upon dehydration and salt treatment, AtNCED3, encoding 9-cis-epoxycarotenoid dioxygenase, and P5CS1, encoding Delta-1-pyrroline-5-carboxylate synthase, which are key enzymes in ABA and proline synthesis, respectively, were highly induced in annAt1annAt4 plants and to a lesser extent in annAt1 and annAt4 plants, but not in 35S:AnnAt4 plants.	Proline	185-192	annexin 1	Arabidopsis thaliana	241-247
20827430-4	2010	However, we found that the p53 Arg72Pro was associated with an increased risk of esophageal cancer ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.20, 95%CI=1.06-1.36) without any between-study heterogeneity.	Proline	36-39	tumor protein p53	Homo sapiens	27-30
20827430-4	2010	However, we found that the p53 Arg72Pro was associated with an increased risk of esophageal cancer ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.20, 95%CI=1.06-1.36) without any between-study heterogeneity.	Proline	101-104	tumor protein p53	Homo sapiens	27-30
20827430-4	2010	However, we found that the p53 Arg72Pro was associated with an increased risk of esophageal cancer ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.20, 95%CI=1.06-1.36) without any between-study heterogeneity.	Proline	101-104	tumor protein p53	Homo sapiens	27-30
20827430-5	2010	In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity.	Proline	117-120	tumor protein p53	Homo sapiens	108-111
20827430-5	2010	In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity.	Proline	117-120	glutathione S-transferase pi 1	Homo sapiens	329-334
20827430-5	2010	In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity.	Proline	168-171	tumor protein p53	Homo sapiens	108-111
20827430-5	2010	In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity.	Proline	168-171	tumor protein p53	Homo sapiens	108-111
20607281-5	2010	Replacement of proline residues by alanines (188-ASTA) decreased Cavbeta(2) affinity about 20-fold.	Proline	15-22	calcium channel, voltage-dependent, beta 2 subunit	Mus musculus	65-75
20572019-8	2010	However, these TM proline mutations result in a significant reduction of DPP-IV enzymatic activity, comparable to what is found with mutations near the active site.	Proline	18-25	dipeptidyl peptidase 4	Homo sapiens	73-79
20674353-2	2010	Proline prodrug of methotrexate (Pro-MTX) was designed as a substrate of prolidase which is specific for imido bond of dipeptide containing proline and expected to penetrate MDA-MB-231 cells more efficiently.	Proline	0-7	peptidase D	Homo sapiens	73-82
20674353-2	2010	Proline prodrug of methotrexate (Pro-MTX) was designed as a substrate of prolidase which is specific for imido bond of dipeptide containing proline and expected to penetrate MDA-MB-231 cells more efficiently.	Proline	140-147	peptidase D	Homo sapiens	73-82
20550582-1	2010	Saccharomyces cerevisiaeSigma1278b has the MPR1 gene encoding the N-acetyltransferase Mpr1 that acetylates the proline metabolism intermediate Delta(1)-pyrroline-5-carboxylate (P5C)/glutamate-gamma-semialdehyde (GSA) in vitro.	Proline	111-118	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	43-47
20550582-1	2010	Saccharomyces cerevisiaeSigma1278b has the MPR1 gene encoding the N-acetyltransferase Mpr1 that acetylates the proline metabolism intermediate Delta(1)-pyrroline-5-carboxylate (P5C)/glutamate-gamma-semialdehyde (GSA) in vitro.	Proline	111-118	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	86-90
20550582-5	2010	Gene disruption analysis revealed that Mpr1 converts P5C/GSA into N-acetyl-GSA for arginine synthesis in the mitochondria, indicating that Mpr1 mediates the proline and arginine metabolic pathways.	Proline	157-164	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	39-43
20550582-5	2010	Gene disruption analysis revealed that Mpr1 converts P5C/GSA into N-acetyl-GSA for arginine synthesis in the mitochondria, indicating that Mpr1 mediates the proline and arginine metabolic pathways.	Proline	157-164	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	139-143
20638934-8	2010	The mutation results in deletion of 11 amino acids in the N-terminus of the protein, a proline-rich region as a binding site for Src homology 3 (SH3) domains associated with Src-family protein tyrosine kinase (TK) pathway.	Proline	87-94	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	129-132
20638934-8	2010	The mutation results in deletion of 11 amino acids in the N-terminus of the protein, a proline-rich region as a binding site for Src homology 3 (SH3) domains associated with Src-family protein tyrosine kinase (TK) pathway.	Proline	87-94	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	174-178
20304043-1	2010	Prolyl endopeptidase (PEP) is a serine protease that cleaves small peptides at the carboxyl side of L-proline.	Proline	100-109	prolyl endopeptidase	Rattus norvegicus	0-20
20304043-1	2010	Prolyl endopeptidase (PEP) is a serine protease that cleaves small peptides at the carboxyl side of L-proline.	Proline	100-109	prolyl endopeptidase	Rattus norvegicus	22-25
20610720-2	2010	Virus egress from cells depended on open reading frame 3 (ORF3) protein, and a proline-rich sequence in ORF3 was important for egress from cultured cells and for infection of macaques.	Proline	79-86	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	104-108
20598093-0	2010	The proline 160 in the selectivity filter of the Arabidopsis NO(3)(-)/H(+) exchanger AtCLCa is essential for nitrate accumulation in planta.	Proline	4-11	chloride channel A	Arabidopsis thaliana	85-91
20598093-5	2010	By monitoring AtCLCa activity in its native environment, we show that if proline 160 in AtCLCa is changed to a serine (AtCLCa(P160S) ), the transporter loses its nitrate selectivity, but the anion proton exchange mechanism is unaffected.	Proline	73-80	chloride channel A	Arabidopsis thaliana	14-20
20598093-5	2010	By monitoring AtCLCa activity in its native environment, we show that if proline 160 in AtCLCa is changed to a serine (AtCLCa(P160S) ), the transporter loses its nitrate selectivity, but the anion proton exchange mechanism is unaffected.	Proline	73-80	chloride channel A	Arabidopsis thaliana	88-94
20598093-5	2010	By monitoring AtCLCa activity in its native environment, we show that if proline 160 in AtCLCa is changed to a serine (AtCLCa(P160S) ), the transporter loses its nitrate selectivity, but the anion proton exchange mechanism is unaffected.	Proline	73-80	chloride channel A	Arabidopsis thaliana	131-132
20598093-8	2010	Our results confirm the significance of this amino acid in the conserved selectivity filter of CLC proteins and highlight the importance of the proline in AtCLCa for nitrate metabolism in Arabidopsis.	Proline	144-151	chloride channel A	Arabidopsis thaliana	155-161
20656895-6	2010	Upon dehydration and salt treatment, AtNCED3, encoding 9-cis-epoxycarotenoid dioxygenase, and P5CS1, encoding Delta-1-pyrroline-5-carboxylate synthase, which are key enzymes in ABA and proline synthesis, respectively, were highly induced in annAt1annAt4 plants and to a lesser extent in annAt1 and annAt4 plants, but not in 35S:AnnAt4 plants.	Proline	185-192	annexin 4	Arabidopsis thaliana	247-253
20629175-1	2010	In the study of rabbit muscle pyruvate kinase (M1-PYK), proline has previously been used as an osmolyte in an attempt to determine a role for preexisting conformational equilibria in allosteric regulation.	Proline	56-63	pyruvate kinase PKLR	Oryctolagus cuniculus	30-45
20656895-6	2010	Upon dehydration and salt treatment, AtNCED3, encoding 9-cis-epoxycarotenoid dioxygenase, and P5CS1, encoding Delta-1-pyrroline-5-carboxylate synthase, which are key enzymes in ABA and proline synthesis, respectively, were highly induced in annAt1annAt4 plants and to a lesser extent in annAt1 and annAt4 plants, but not in 35S:AnnAt4 plants.	Proline	185-192	annexin 4	Arabidopsis thaliana	328-334
20530479-4	2010	Phosphorylated Pro-Gly-Ser(553)-Pro motif is a putative binding site to Nedd4 ubiquitin ligases, and we hypothesized that Nedd4-like ubiquitin ligases may contribute to channel ubiquitination and internalization.	Proline	15-18	neural precursor cell expressed, developmentally down-regulated 4	Mus musculus	72-77
21103216-8	2010	Taken together, these results suggest a role for proline residues 53 and 481 in the linker regions of human NTPDase3 for coupling nucleotide binding at the enzyme active site to movements and/or rearrangements of the transmembrane helices necessary for optimal nucleotide hydrolysis.	Proline	49-56	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	108-116
20630574-8	2010	However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians.	Proline	112-115	tumor protein p53	Homo sapiens	78-82
20630574-8	2010	However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians.	Proline	116-119	tumor protein p53	Homo sapiens	78-82
20630574-8	2010	However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians.	Proline	116-119	tumor protein p53	Homo sapiens	78-82
20630574-8	2010	However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians.	Proline	116-119	tumor protein p53	Homo sapiens	78-82
20630574-8	2010	However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians.	Proline	116-119	tumor protein p53	Homo sapiens	78-82
20566626-1	2010	Acetylcholinesterase (AChE) is anchored onto cell membranes by the transmembrane protein PRiMA (proline-rich membrane anchor) as a tetrameric globular form that is prominently expressed in vertebrate brain.	Proline	96-103	acetylcholinesterase (Cartwright blood group)	Gallus gallus	0-20
20566626-1	2010	Acetylcholinesterase (AChE) is anchored onto cell membranes by the transmembrane protein PRiMA (proline-rich membrane anchor) as a tetrameric globular form that is prominently expressed in vertebrate brain.	Proline	96-103	acetylcholinesterase (Cartwright blood group)	Gallus gallus	22-26
20566626-3	2010	A single type of AChE-BChE hybrid tetramer was formed in cell cultures by co-transfection of cDNAs encoding AChE(T) and BChE(T) with proline-rich attachment domain-containing proteins, PRiMA I, PRiMA II, or a fragment of ColQ having a C-terminal GPI addition signal (Q(N-GPI)).	Proline	133-140	acetylcholinesterase (Cartwright blood group)	Gallus gallus	17-21
20566626-3	2010	A single type of AChE-BChE hybrid tetramer was formed in cell cultures by co-transfection of cDNAs encoding AChE(T) and BChE(T) with proline-rich attachment domain-containing proteins, PRiMA I, PRiMA II, or a fragment of ColQ having a C-terminal GPI addition signal (Q(N-GPI)).	Proline	133-140	butyrylcholinesterase	Gallus gallus	22-26
20717630-1	2010	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, and plays multiple roles in neuron development and synaptic plasticity.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
20717630-1	2010	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, and plays multiple roles in neuron development and synaptic plasticity.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
20415579-3	2010	Matrix metalloproteinases degrading collagen are activated during stress to make proline available, and proline oxidase, the first enzyme in proline degradation, is induced by p53, peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands, and by AMP-activated protein kinase downregulating mTOR.	Proline	104-111	tumor protein p53	Homo sapiens	176-179
20415579-3	2010	Matrix metalloproteinases degrading collagen are activated during stress to make proline available, and proline oxidase, the first enzyme in proline degradation, is induced by p53, peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands, and by AMP-activated protein kinase downregulating mTOR.	Proline	104-111	peroxisome proliferator activated receptor gamma	Homo sapiens	181-229
20415579-3	2010	Matrix metalloproteinases degrading collagen are activated during stress to make proline available, and proline oxidase, the first enzyme in proline degradation, is induced by p53, peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands, and by AMP-activated protein kinase downregulating mTOR.	Proline	104-111	peroxisome proliferator activated receptor gamma	Homo sapiens	231-240
20415579-3	2010	Matrix metalloproteinases degrading collagen are activated during stress to make proline available, and proline oxidase, the first enzyme in proline degradation, is induced by p53, peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands, and by AMP-activated protein kinase downregulating mTOR.	Proline	104-111	mechanistic target of rapamycin kinase	Homo sapiens	310-314
20554525-7	2010	Furthermore, Grb2 did not bind to a single region but rather to different regions of NPM-ALK, mainly Tyr(152-156), Tyr(567), and a proline-rich region, Pro(415-417).	Proline	131-138	growth factor receptor bound protein 2	Homo sapiens	13-17
20554525-7	2010	Furthermore, Grb2 did not bind to a single region but rather to different regions of NPM-ALK, mainly Tyr(152-156), Tyr(567), and a proline-rich region, Pro(415-417).	Proline	152-155	growth factor receptor bound protein 2	Homo sapiens	13-17
21103216-0	2010	Proline residues link the active site to transmembrane domain movements in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3).	Proline	0-7	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	81-125
21103216-0	2010	Proline residues link the active site to transmembrane domain movements in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3).	Proline	0-7	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	127-135
21103216-2	2010	Using site-directed mutagenesis, the roles of the conserved proline residues (N-terminal: P52 and P53; C-terminal: P472, P476, P481, P484, and P485) of human NTPDase3, located in the "linker regions" that connect the N- and C-terminal transmembrane helices with the extracellular active site, were examined.	Proline	60-67	nuclear factor kappa B subunit 2	Homo sapiens	90-93
21103216-2	2010	Using site-directed mutagenesis, the roles of the conserved proline residues (N-terminal: P52 and P53; C-terminal: P472, P476, P481, P484, and P485) of human NTPDase3, located in the "linker regions" that connect the N- and C-terminal transmembrane helices with the extracellular active site, were examined.	Proline	60-67	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	158-166
21103216-5	2010	Proline to alanine substitutions at P53, P481, P484, and P485 in the V42C background, as well as P53, P481, and P484 in the G489C background, exhibited decreased nucleotidase activities.	Proline	0-7	tumor protein p53	Homo sapiens	36-39
20516071-7	2010	MIF inhibitors emerging from these studies could be divided into three categories based on their mechanism of action: 1) molecules that covalently modify the catalytic site at the N-terminal proline residue, Pro(1); 2) a novel class of catalytic site inhibitors; and finally 3) molecules that disrupt the trimeric structure of MIF.	Proline	191-198	macrophage migration inhibitory factor	Homo sapiens	0-3
20530479-4	2010	Phosphorylated Pro-Gly-Ser(553)-Pro motif is a putative binding site to Nedd4 ubiquitin ligases, and we hypothesized that Nedd4-like ubiquitin ligases may contribute to channel ubiquitination and internalization.	Proline	15-18	neural precursor cell expressed, developmentally down-regulated 4	Mus musculus	122-127
20530479-7	2010	We also report that the ubiquitin ligase Nedd4-2 interacts with Na(v)1.6 via a Pro-Ser-Tyr(1945) motif in the C terminus of the channel and reduces Na(v)1.6 current density, and we show that this regulation requires both the Pro-Gly-Ser-Pro motif in L1 and the Pro-Ser-Tyr motif in the C terminus.	Proline	79-82	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	41-48
20530479-7	2010	We also report that the ubiquitin ligase Nedd4-2 interacts with Na(v)1.6 via a Pro-Ser-Tyr(1945) motif in the C terminus of the channel and reduces Na(v)1.6 current density, and we show that this regulation requires both the Pro-Gly-Ser-Pro motif in L1 and the Pro-Ser-Tyr motif in the C terminus.	Proline	79-82	sodium channel, voltage-gated, type VIII, alpha	Mus musculus	64-72
20530479-7	2010	We also report that the ubiquitin ligase Nedd4-2 interacts with Na(v)1.6 via a Pro-Ser-Tyr(1945) motif in the C terminus of the channel and reduces Na(v)1.6 current density, and we show that this regulation requires both the Pro-Gly-Ser-Pro motif in L1 and the Pro-Ser-Tyr motif in the C terminus.	Proline	79-82	sodium channel, voltage-gated, type VIII, alpha	Mus musculus	148-156
20530479-7	2010	We also report that the ubiquitin ligase Nedd4-2 interacts with Na(v)1.6 via a Pro-Ser-Tyr(1945) motif in the C terminus of the channel and reduces Na(v)1.6 current density, and we show that this regulation requires both the Pro-Gly-Ser-Pro motif in L1 and the Pro-Ser-Tyr motif in the C terminus.	Proline	225-228	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	41-48
20530479-7	2010	We also report that the ubiquitin ligase Nedd4-2 interacts with Na(v)1.6 via a Pro-Ser-Tyr(1945) motif in the C terminus of the channel and reduces Na(v)1.6 current density, and we show that this regulation requires both the Pro-Gly-Ser-Pro motif in L1 and the Pro-Ser-Tyr motif in the C terminus.	Proline	225-228	sodium channel, voltage-gated, type VIII, alpha	Mus musculus	64-72
20530479-7	2010	We also report that the ubiquitin ligase Nedd4-2 interacts with Na(v)1.6 via a Pro-Ser-Tyr(1945) motif in the C terminus of the channel and reduces Na(v)1.6 current density, and we show that this regulation requires both the Pro-Gly-Ser-Pro motif in L1 and the Pro-Ser-Tyr motif in the C terminus.	Proline	225-228	sodium channel, voltage-gated, type VIII, alpha	Mus musculus	148-156
20530479-7	2010	We also report that the ubiquitin ligase Nedd4-2 interacts with Na(v)1.6 via a Pro-Ser-Tyr(1945) motif in the C terminus of the channel and reduces Na(v)1.6 current density, and we show that this regulation requires both the Pro-Gly-Ser-Pro motif in L1 and the Pro-Ser-Tyr motif in the C terminus.	Proline	225-228	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	41-48
20530479-7	2010	We also report that the ubiquitin ligase Nedd4-2 interacts with Na(v)1.6 via a Pro-Ser-Tyr(1945) motif in the C terminus of the channel and reduces Na(v)1.6 current density, and we show that this regulation requires both the Pro-Gly-Ser-Pro motif in L1 and the Pro-Ser-Tyr motif in the C terminus.	Proline	225-228	sodium channel, voltage-gated, type VIII, alpha	Mus musculus	64-72
20530479-7	2010	We also report that the ubiquitin ligase Nedd4-2 interacts with Na(v)1.6 via a Pro-Ser-Tyr(1945) motif in the C terminus of the channel and reduces Na(v)1.6 current density, and we show that this regulation requires both the Pro-Gly-Ser-Pro motif in L1 and the Pro-Ser-Tyr motif in the C terminus.	Proline	225-228	sodium channel, voltage-gated, type VIII, alpha	Mus musculus	148-156
20530479-9	2010	Thus, phosphorylation of the Pro-Gly-Ser-Pro motif within L1 of Na(v)1.6 is necessary for stress-induced current modulation, with positive or negative regulation depending upon the availability of the C-terminal Pro-Ser-Tyr motif to bind Nedd4-2.	Proline	29-32	sodium channel, voltage-gated, type VIII, alpha	Mus musculus	64-72
20530479-9	2010	Thus, phosphorylation of the Pro-Gly-Ser-Pro motif within L1 of Na(v)1.6 is necessary for stress-induced current modulation, with positive or negative regulation depending upon the availability of the C-terminal Pro-Ser-Tyr motif to bind Nedd4-2.	Proline	29-32	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	238-245
20529865-2	2010	Here, we show that the uncoating process requires the interaction of the capsid (CA) protein with the peptidyl-prolyl isomerase Pin1 that specifically recognizes the phosphorylated serine/threonine residue followed by proline.	Proline	218-225	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	128-132
19958256-6	2010	Thereby quercetin interfered with the proline hydroxylation-dependent HIF-1alpha protein destabilization in the N-terminal HIF-1alpha transactivation domain.	Proline	38-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-80
19958256-6	2010	Thereby quercetin interfered with the proline hydroxylation-dependent HIF-1alpha protein destabilization in the N-terminal HIF-1alpha transactivation domain.	Proline	38-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-133
20703084-4	2010	p16(INK4a) induces a profound decrease in the CDK4/6-mediated pRb phosphorylation on Ser-807/811, a downregulation of CDK2 and CDK1 protein expression independently of G(1) accumulation, and a decrease in Thr/Pro phosphorylation in part carried out by CDKs.	Proline	209-212	cyclin dependent kinase inhibitor 2A	Homo sapiens	0-3
20703084-4	2010	p16(INK4a) induces a profound decrease in the CDK4/6-mediated pRb phosphorylation on Ser-807/811, a downregulation of CDK2 and CDK1 protein expression independently of G(1) accumulation, and a decrease in Thr/Pro phosphorylation in part carried out by CDKs.	Proline	209-212	cyclin dependent kinase inhibitor 2A	Homo sapiens	4-9
20703084-4	2010	p16(INK4a) induces a profound decrease in the CDK4/6-mediated pRb phosphorylation on Ser-807/811, a downregulation of CDK2 and CDK1 protein expression independently of G(1) accumulation, and a decrease in Thr/Pro phosphorylation in part carried out by CDKs.	Proline	209-212	cyclin dependent kinase 4	Homo sapiens	46-52
20703084-4	2010	p16(INK4a) induces a profound decrease in the CDK4/6-mediated pRb phosphorylation on Ser-807/811, a downregulation of CDK2 and CDK1 protein expression independently of G(1) accumulation, and a decrease in Thr/Pro phosphorylation in part carried out by CDKs.	Proline	209-212	RB transcriptional corepressor 1	Homo sapiens	62-65
20519628-2	2010	The binding site of proline and acidic amino acid-rich protein (PAR) transcription factors in the promoter of the LMO2 gene plays a central role in hematopoietic-specific expression.	Proline	20-27	LIM domain only 2	Homo sapiens	114-118
20529865-6	2010	Glutathione S-transferase pulldown assays demonstrated a direct interaction between Pin1 and the HIV-1 core via the Ser(16)-Pro(17) motif.	Proline	124-127	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	84-88
20229235-5	2010	Here, we summarize how proline-directed kinases (Gsk3, PKA, Pftk1, Grk5/6) and non-proline-directed kinases (CK1 family) act upon Lrp6, how the phosphorylation is regulated by ligand binding and mitosis, and how Lrp6 phosphorylation leads to beta-catenin stabilization.	Proline	23-30	LDL receptor related protein 6	Homo sapiens	130-134
20677832-4	2010	Here, we show that CYP33 mediates downregulation of the expression of MLL target genes HOXC8, HOXA9, CDKN1B, and C-MYC, in a proline isomerase-dependent manner.	Proline	125-132	peptidylprolyl isomerase E	Homo sapiens	19-24
20677832-4	2010	Here, we show that CYP33 mediates downregulation of the expression of MLL target genes HOXC8, HOXA9, CDKN1B, and C-MYC, in a proline isomerase-dependent manner.	Proline	125-132	lysine methyltransferase 2A	Homo sapiens	70-73
20677832-4	2010	Here, we show that CYP33 mediates downregulation of the expression of MLL target genes HOXC8, HOXA9, CDKN1B, and C-MYC, in a proline isomerase-dependent manner.	Proline	125-132	homeobox C8	Homo sapiens	87-92
20677832-4	2010	Here, we show that CYP33 mediates downregulation of the expression of MLL target genes HOXC8, HOXA9, CDKN1B, and C-MYC, in a proline isomerase-dependent manner.	Proline	125-132	homeobox A9	Homo sapiens	94-99
20677832-4	2010	Here, we show that CYP33 mediates downregulation of the expression of MLL target genes HOXC8, HOXA9, CDKN1B, and C-MYC, in a proline isomerase-dependent manner.	Proline	125-132	cyclin dependent kinase inhibitor 1B	Homo sapiens	101-107
20677832-4	2010	Here, we show that CYP33 mediates downregulation of the expression of MLL target genes HOXC8, HOXA9, CDKN1B, and C-MYC, in a proline isomerase-dependent manner.	Proline	125-132	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	113-118
20681719-1	2010	Prolyl 4-hydroxylases install a hydroxyl group in the 4R configuration on the gamma-carbon atom of certain (2S)-proline (Pro) residues in tropocollagen, elastin, and other proteins to form (2S,4R)-4-hydroxyproline (Hyp).	Proline	0-3	elastin	Homo sapiens	153-160
20229235-5	2010	Here, we summarize how proline-directed kinases (Gsk3, PKA, Pftk1, Grk5/6) and non-proline-directed kinases (CK1 family) act upon Lrp6, how the phosphorylation is regulated by ligand binding and mitosis, and how Lrp6 phosphorylation leads to beta-catenin stabilization.	Proline	23-30	LDL receptor related protein 6	Homo sapiens	212-216
20229235-5	2010	Here, we summarize how proline-directed kinases (Gsk3, PKA, Pftk1, Grk5/6) and non-proline-directed kinases (CK1 family) act upon Lrp6, how the phosphorylation is regulated by ligand binding and mitosis, and how Lrp6 phosphorylation leads to beta-catenin stabilization.	Proline	23-30	catenin beta 1	Homo sapiens	242-254
20229235-5	2010	Here, we summarize how proline-directed kinases (Gsk3, PKA, Pftk1, Grk5/6) and non-proline-directed kinases (CK1 family) act upon Lrp6, how the phosphorylation is regulated by ligand binding and mitosis, and how Lrp6 phosphorylation leads to beta-catenin stabilization.	Proline	83-90	LDL receptor related protein 6	Homo sapiens	130-134
20179965-2	2010	Here, we report a novel homozygous point mutation of SRD5A2 gene at codon 65 in exon 1, due to a proline for alanine substitution in a Turkish family whose proband has severe undervirilization.	Proline	97-104	steroid 5 alpha-reductase 2	Homo sapiens	53-59
20230853-0	2010	The residues (35)proline and (41)cysteine of chicken IL-2 are critical for binding to chicken CD25.	Proline	17-24	interleukin 15	Gallus gallus	53-57
20614171-1	2010	Mitochondrial membrane carriers containing proline and cysteine, such as adenine nucleotide translocase (ANT), are potential targets of cyclophilin D (CyP-D) and potential Ca(2+)-induced permeability transition pore (PTP) components or regulators; CyP-D, a mitochondrial peptidyl-prolyl cis-trans isomerase, is the probable target of the PTP inhibitor cyclosporine A (CsA).	Proline	43-50	peptidylprolyl isomerase D	Rattus norvegicus	136-149
20585109-10	2010	In cultured neonatal rat cardiac myocytes, [3H]proline incorporation and Western blot assays revealed that A20 expression suppressed transforming growth factor-beta-induced collagen synthesis and transforming growth factor-beta-activated kinase 1-dependent Smad 2/3/4 activation.	Proline	47-54	tumor necrosis factor, alpha-induced protein 3	Mus musculus	107-110
20544725-1	2010	The constitutive interaction between the P1 domain (a 67-amino-acid functional domain within the proline-rich region) of SLP76 and the SH3 domain of phospholipase Cgamma1 (PLCgamma1) has been shown.	Proline	97-104	lymphocyte cytosolic protein 2	Homo sapiens	121-126
20544725-1	2010	The constitutive interaction between the P1 domain (a 67-amino-acid functional domain within the proline-rich region) of SLP76 and the SH3 domain of phospholipase Cgamma1 (PLCgamma1) has been shown.	Proline	97-104	phospholipase C gamma 1	Homo sapiens	149-170
20614171-1	2010	Mitochondrial membrane carriers containing proline and cysteine, such as adenine nucleotide translocase (ANT), are potential targets of cyclophilin D (CyP-D) and potential Ca(2+)-induced permeability transition pore (PTP) components or regulators; CyP-D, a mitochondrial peptidyl-prolyl cis-trans isomerase, is the probable target of the PTP inhibitor cyclosporine A (CsA).	Proline	43-50	peptidylprolyl isomerase D	Rattus norvegicus	151-156
20614171-1	2010	Mitochondrial membrane carriers containing proline and cysteine, such as adenine nucleotide translocase (ANT), are potential targets of cyclophilin D (CyP-D) and potential Ca(2+)-induced permeability transition pore (PTP) components or regulators; CyP-D, a mitochondrial peptidyl-prolyl cis-trans isomerase, is the probable target of the PTP inhibitor cyclosporine A (CsA).	Proline	43-50	peptidylprolyl isomerase D	Rattus norvegicus	248-253
20661422-5	2010	The substitution of a glutamine by a proline at the position 212 introduces novel structural differences in comparison to the known wild-type PrP structures.	Proline	37-44	prion protein	Homo sapiens	142-145
20517885-1	2010	Prolylcarboxypeptidase (PRCP) is a serine protease that catalyzes the cleavage of C-terminal amino acids linked to proline in peptides.	Proline	115-122	prolylcarboxypeptidase	Homo sapiens	0-22
20517885-1	2010	Prolylcarboxypeptidase (PRCP) is a serine protease that catalyzes the cleavage of C-terminal amino acids linked to proline in peptides.	Proline	115-122	prolylcarboxypeptidase	Homo sapiens	24-28
20520921-7	2010	Specificities in the NS4B/5A mechanism can be attributed to the presence of a Proline residue in the substrate P2 position.	Proline	78-85	polyprotein;protein F	Hepatitis C virus genotype 1	21-25
20668692-2	2010	Human cdc25C is phosphorylated on Proline-dependent SP and TP sites when it becomes active at mitosis and the prevalent model is that this phosphorylation/activation of cdc25C would be part of an amplification loop with cdk1/cyclin B1.	Proline	34-41	cell division cycle 25C	Homo sapiens	6-12
20668692-2	2010	Human cdc25C is phosphorylated on Proline-dependent SP and TP sites when it becomes active at mitosis and the prevalent model is that this phosphorylation/activation of cdc25C would be part of an amplification loop with cdk1/cyclin B1.	Proline	34-41	cell division cycle 25C	Homo sapiens	169-175
20668692-2	2010	Human cdc25C is phosphorylated on Proline-dependent SP and TP sites when it becomes active at mitosis and the prevalent model is that this phosphorylation/activation of cdc25C would be part of an amplification loop with cdk1/cyclin B1.	Proline	34-41	cyclin dependent kinase 1	Homo sapiens	220-224
20668692-2	2010	Human cdc25C is phosphorylated on Proline-dependent SP and TP sites when it becomes active at mitosis and the prevalent model is that this phosphorylation/activation of cdc25C would be part of an amplification loop with cdk1/cyclin B1.	Proline	34-41	cyclin B1	Homo sapiens	225-234
20421238-6	2010	We identified a novel germ line variant of the 177 mutant (Pro to Arg; P177R) of p53 by genomic sequencing.	Proline	59-62	tumor protein p53	Homo sapiens	81-84
21994697-3	2010	The major proline substrates are located in domain II of NS5A, centered around a "DY" dipeptide motif that regulates CyPA dependence and CsA resistance.	Proline	10-17	peptidylprolyl isomerase A	Homo sapiens	117-121
20525694-3	2010	All have a highly conserved N-terminal tyrosine kinase binding domain, a catalytic RING finger domain, and a C-terminal proline-rich domain that mediates interactions with Src homology 3 (SH3) containing proteins.	Proline	120-127	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	172-175
20587514-1	2010	The p53 tumor suppressor gene contains a common single nucleotide polymorphism (SNP) that results in either an arginine or proline at position 72 of the p53 protein.	Proline	123-130	transformation related protein 53, pseudogene	Mus musculus	4-7
20471375-1	2010	In the central nervous system, acetylcholinesterase (AChE) is present in a tetrameric form that is anchored to membranes via a proline-rich membrane anchor (PRiMA).	Proline	127-134	acetylcholinesterase	Rattus norvegicus	31-51
20471375-1	2010	In the central nervous system, acetylcholinesterase (AChE) is present in a tetrameric form that is anchored to membranes via a proline-rich membrane anchor (PRiMA).	Proline	127-134	acetylcholinesterase	Rattus norvegicus	53-57
20471375-1	2010	In the central nervous system, acetylcholinesterase (AChE) is present in a tetrameric form that is anchored to membranes via a proline-rich membrane anchor (PRiMA).	Proline	127-134	proline rich membrane anchor 1	Rattus norvegicus	157-162
20587514-1	2010	The p53 tumor suppressor gene contains a common single nucleotide polymorphism (SNP) that results in either an arginine or proline at position 72 of the p53 protein.	Proline	123-130	transformation related protein 53, pseudogene	Mus musculus	153-156
20527928-7	2010	This intramolecular interaction could, at least partially, explain the remarkable specificity of Nck toward proteins with proline-rich sequences.	Proline	122-129	NCK adaptor protein 1	Homo sapiens	97-100
20493854-4	2010	The Thr71 site has a motif for proline-directed kinases and is the main phosphorylation site of SR.	Proline	31-38	serine racemase	Mus musculus	96-98
20644716-8	2010	Mutation of either tyrosine 660 or a proline-rich sequence (PPPRPPK) simultaneously interrupted this complex and reduced by approximately 50% the capacity of Themis2 to promote LPS-induced TNF production.	Proline	37-44	thymocyte selection associated family member 2	Homo sapiens	158-165
20644716-8	2010	Mutation of either tyrosine 660 or a proline-rich sequence (PPPRPPK) simultaneously interrupted this complex and reduced by approximately 50% the capacity of Themis2 to promote LPS-induced TNF production.	Proline	37-44	tumor necrosis factor	Homo sapiens	189-192
20418908-3	2010	The association was mediated by the multiple proline-rich regions of Eps8 and the C-terminal SH3-WWB containing domains of IRSp53S.	Proline	45-52	epidermal growth factor receptor pathway substrate 8	Homo sapiens	69-73
20515662-3	2010	We demonstrate that insulin stimulates phosphorylation of tyrosine and threonine/proline residues on the p85 regulatory subunit of PI3K in Huh-7, and HEK 293 cells.	Proline	81-88	insulin	Homo sapiens	20-27
20460131-1	2010	The nuclear protein cyclophilin 33 (Cyp33) is a peptidyl-prolyl cis-trans isomerase that catalyzes cis-trans isomerization of the peptide bond preceding a proline and promotes folding and conformational changes in folded and unfolded proteins.	Proline	155-162	peptidylprolyl isomerase E	Homo sapiens	20-34
20460131-1	2010	The nuclear protein cyclophilin 33 (Cyp33) is a peptidyl-prolyl cis-trans isomerase that catalyzes cis-trans isomerization of the peptide bond preceding a proline and promotes folding and conformational changes in folded and unfolded proteins.	Proline	155-162	peptidylprolyl isomerase E	Homo sapiens	36-41
20380571-4	2010	The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes for P53 codon 72 were 51.7%, 41.4%, and 6.9% in patients and 42.6%, 47.3%, and 10.1% in controls, respectively.	Proline	32-35	tumor protein p53	Homo sapiens	63-66
20395597-6	2010	This motif is located near the ABCA1 Pro-Glu-Ser-Thr sequence, and the presence of calmodulin/Ca(2+) protected the peptides from proteolysis by calpain.	Proline	37-40	ATP binding cassette subfamily A member 1	Homo sapiens	31-36
20399812-3	2010	The mutation substituted a leucine for a proline in the PSTAIRE helix, the central motif in the interaction of the cdk with its regulatory cyclin subunit.	Proline	41-48	proliferating cell nuclear antigen	Homo sapiens	139-145
20380571-4	2010	The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes for P53 codon 72 were 51.7%, 41.4%, and 6.9% in patients and 42.6%, 47.3%, and 10.1% in controls, respectively.	Proline	41-44	tumor protein p53	Homo sapiens	63-66
21217974-21	2010	Therefore, in conclusion, the unipedicled TRAM flap should be regarded as a valuable option in breast reconstruction provided careful repair of the abdominal wall defect is undertaken using Proline mesh.	Proline	190-197	translocation associated membrane protein 1	Homo sapiens	42-46
20389250-0	2010	Pro variant of TP53 Arg72Pro contributes to esophageal squamous cell carcinoma risk: evidence from a meta-analysis.	Proline	0-3	tumor protein p53	Homo sapiens	15-19
20491914-5	2010	Using truncated proteins, we found that the interaction with SNX9 is mediated by the proline-rich domain (PRD) of Itch, a domain distinct from the conventional WW recognition domain, and the SH3 domain of SNX9.	Proline	85-92	sorting nexin 9	Homo sapiens	61-65
20491914-5	2010	Using truncated proteins, we found that the interaction with SNX9 is mediated by the proline-rich domain (PRD) of Itch, a domain distinct from the conventional WW recognition domain, and the SH3 domain of SNX9.	Proline	85-92	itchy E3 ubiquitin protein ligase	Homo sapiens	114-118
21844680-4	2010	Ornithine delta-aminotransferase (delta-OAT) is an important enzyme in proline biosynthetic pathway.	Proline	71-78	ornithine aminotransferase	Homo sapiens	0-32
20587534-3	2010	Mutation of a conserved leucine residue to proline in the high-affinity DNA binding site of RPA (residue L221 in human RPA) has been shown to have defects in DNA repair and a high rate of chromosomal rearrangements in yeast.	Proline	43-50	replication protein A1	Homo sapiens	92-95
20587534-3	2010	Mutation of a conserved leucine residue to proline in the high-affinity DNA binding site of RPA (residue L221 in human RPA) has been shown to have defects in DNA repair and a high rate of chromosomal rearrangements in yeast.	Proline	43-50	replication protein A1	Homo sapiens	119-122
23572976-4	2010	Exogenous application of 5 mM betaine or 5 mM proline resulted in an increase in GSH and AsA content, maintenance of a high GSH/GSSG ratio and increased the activities of APX, DHAR, MDHAR, GR, GST, GPX, CAT, Gly I and Gly II involved in ROS and MG detoxification system as compared to the control and mostly also Cd-stressed plants, with a concomitant decrease in GSSG content, H2O2 and lipid peroxidation level.	Proline	46-53	L-ascorbate peroxidase, cytosolic	Vigna radiata	171-174
20118822-5	2010	Real-time polymerase chain reaction also confirmed that gene expressions of angiotensin II receptor-like 1 (AGTRL1) and proline rich 15 (PRR15) were down-regulated at day 3 after the VMH lesions.	Proline	120-127	proline rich 15	Rattus norvegicus	137-142
23572976-4	2010	Exogenous application of 5 mM betaine or 5 mM proline resulted in an increase in GSH and AsA content, maintenance of a high GSH/GSSG ratio and increased the activities of APX, DHAR, MDHAR, GR, GST, GPX, CAT, Gly I and Gly II involved in ROS and MG detoxification system as compared to the control and mostly also Cd-stressed plants, with a concomitant decrease in GSSG content, H2O2 and lipid peroxidation level.	Proline	46-53	monodehydroascorbate reductase	Vigna radiata	182-187
23572976-4	2010	Exogenous application of 5 mM betaine or 5 mM proline resulted in an increase in GSH and AsA content, maintenance of a high GSH/GSSG ratio and increased the activities of APX, DHAR, MDHAR, GR, GST, GPX, CAT, Gly I and Gly II involved in ROS and MG detoxification system as compared to the control and mostly also Cd-stressed plants, with a concomitant decrease in GSSG content, H2O2 and lipid peroxidation level.	Proline	46-53	glutathione S-transferase	Vigna radiata	193-196
23572976-4	2010	Exogenous application of 5 mM betaine or 5 mM proline resulted in an increase in GSH and AsA content, maintenance of a high GSH/GSSG ratio and increased the activities of APX, DHAR, MDHAR, GR, GST, GPX, CAT, Gly I and Gly II involved in ROS and MG detoxification system as compared to the control and mostly also Cd-stressed plants, with a concomitant decrease in GSSG content, H2O2 and lipid peroxidation level.	Proline	46-53	catalase	Vigna radiata	203-206
20404345-9	2010	Efficient interaction between Rac1 and CD2AP requires both the proline-rich domain and the poly-basic region in the Rac1 C terminus, and at least two of the three N-terminal SH3 domains of CD2AP.	Proline	63-70	Rac family small GTPase 1	Homo sapiens	30-34
20221582-8	2010	Comparative sequencing of RGA open-reading frames (ORFs) of ds-1 and wild-type cultivars revealed a single proline (P)-to-leucine (L) substitution that may lead to a gain-of-function mutation in GA signaling.	Proline	107-114	DELLA protein RGA2	Brassica napus	26-29
20221582-10	2010	A yeast two-hybrid assay confirmed that this mutation inhibited the interaction between Bnrga-ds/Atrga-ds and the GA receptor, AtGID1A, in the presence of GA(3), suggesting that the conserved proline residue in the VHYNP motif of DELLA protein directly participates in DELLA-GID1 interaction.	Proline	192-199	DELLA protein RGA2	Brassica napus	88-93
20221582-10	2010	A yeast two-hybrid assay confirmed that this mutation inhibited the interaction between Bnrga-ds/Atrga-ds and the GA receptor, AtGID1A, in the presence of GA(3), suggesting that the conserved proline residue in the VHYNP motif of DELLA protein directly participates in DELLA-GID1 interaction.	Proline	192-199	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	127-134
20461086-1	2010	Originally identified as the enzymes responsible for catalysing the oxidation of specific, conserved proline residues within hypoxia-inducible factor-1alpha (HIF-1alpha), the additional roles for the prolyl hydroxylase domain (PHD) proteins have remained elusive.	Proline	101-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-156
20461086-1	2010	Originally identified as the enzymes responsible for catalysing the oxidation of specific, conserved proline residues within hypoxia-inducible factor-1alpha (HIF-1alpha), the additional roles for the prolyl hydroxylase domain (PHD) proteins have remained elusive.	Proline	101-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	158-168
20404345-9	2010	Efficient interaction between Rac1 and CD2AP requires both the proline-rich domain and the poly-basic region in the Rac1 C terminus, and at least two of the three N-terminal SH3 domains of CD2AP.	Proline	63-70	CD2 associated protein	Homo sapiens	39-44
20446923-12	2010	Increased BNP (B-type natriuretic peptide), MHC (myosin heavy chain) and [(3)H]proline incorporation into cardiomyocytes was identified after hypoxia with the presence of myocardin in hypertrophic cardiomyocytes.	Proline	79-86	myocardin	Rattus norvegicus	171-180
20541251-4	2010	We find that the PPIase domain of CyP33 regulates the conformation of MLL1 through proline isomerization within the PHD3-Bromo linker, thereby disrupting the PHD3-Bromo interface and facilitating binding of the MLL1-PHD3 domain to the CyP33-RRM domain.	Proline	83-90	peptidylprolyl isomerase E	Homo sapiens	34-39
20541251-4	2010	We find that the PPIase domain of CyP33 regulates the conformation of MLL1 through proline isomerization within the PHD3-Bromo linker, thereby disrupting the PHD3-Bromo interface and facilitating binding of the MLL1-PHD3 domain to the CyP33-RRM domain.	Proline	83-90	lysine methyltransferase 2A	Homo sapiens	70-74
20541251-4	2010	We find that the PPIase domain of CyP33 regulates the conformation of MLL1 through proline isomerization within the PHD3-Bromo linker, thereby disrupting the PHD3-Bromo interface and facilitating binding of the MLL1-PHD3 domain to the CyP33-RRM domain.	Proline	83-90	egl-9 family hypoxia inducible factor 3	Homo sapiens	116-120
20541251-4	2010	We find that the PPIase domain of CyP33 regulates the conformation of MLL1 through proline isomerization within the PHD3-Bromo linker, thereby disrupting the PHD3-Bromo interface and facilitating binding of the MLL1-PHD3 domain to the CyP33-RRM domain.	Proline	83-90	egl-9 family hypoxia inducible factor 3	Homo sapiens	158-162
20541251-4	2010	We find that the PPIase domain of CyP33 regulates the conformation of MLL1 through proline isomerization within the PHD3-Bromo linker, thereby disrupting the PHD3-Bromo interface and facilitating binding of the MLL1-PHD3 domain to the CyP33-RRM domain.	Proline	83-90	lysine methyltransferase 2A	Homo sapiens	211-215
20541251-4	2010	We find that the PPIase domain of CyP33 regulates the conformation of MLL1 through proline isomerization within the PHD3-Bromo linker, thereby disrupting the PHD3-Bromo interface and facilitating binding of the MLL1-PHD3 domain to the CyP33-RRM domain.	Proline	83-90	egl-9 family hypoxia inducible factor 3	Homo sapiens	158-162
20541251-4	2010	We find that the PPIase domain of CyP33 regulates the conformation of MLL1 through proline isomerization within the PHD3-Bromo linker, thereby disrupting the PHD3-Bromo interface and facilitating binding of the MLL1-PHD3 domain to the CyP33-RRM domain.	Proline	83-90	peptidylprolyl isomerase E	Homo sapiens	235-240
20602992-0	2010	Flipping MLL1"s switch one proline at a time.	Proline	27-34	lysine methyltransferase 2A	Homo sapiens	9-13
20602992-3	2010	(2010) demonstrate that the cyclophilin CyP33 underpins this regulatory switch by altering the state of MLL1 through cis-trans proline isomerization in the linker region between MLL1"s third PHD finger and bromodomain.	Proline	127-134	lysine methyltransferase 2A	Homo sapiens	104-108
20399421-0	2010	Influence of glucose-templated proline mimetics on the beta-turn conformation of the peptide fragment Ac-Leu-D-Phe-Pro-Val-NMe2 found in Gramicidin S. The synthesis of tetrapeptide-based beta-turn mimetics containing spirocyclic glucose-templated 3-hydroxyproline hybrids Glc3"(S)-5"(R)(CH(2)OH)HypH and Glc3"(S)-5"(S)(CH(2)OH)HypH as proline mimetics is presented.	Proline	31-38	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	123-127
20435044-7	2010	While removal of the proline-rich region (P domain) of PAB1 substantially reduces CCR4 deadenylation at non-PUF3-controlled mRNA and correspondingly blocked eIF4E effects on deadenylation, PUF3 essentially bypassed this P domain requirement.	Proline	21-28	polyadenylate-binding protein	Saccharomyces cerevisiae S288C	55-59
20435044-7	2010	While removal of the proline-rich region (P domain) of PAB1 substantially reduces CCR4 deadenylation at non-PUF3-controlled mRNA and correspondingly blocked eIF4E effects on deadenylation, PUF3 essentially bypassed this P domain requirement.	Proline	21-28	CCR4-NOT core exoribonuclease subunit CCR4	Saccharomyces cerevisiae S288C	82-86
20476722-0	2010	Enantioselective synthesis of syn/anti-1,3-amino alcohols via proline-catalyzed sequential alpha-aminoxylation/alpha-amination and Horner-Wadsworth-Emmons olefination of aldehydes.	Proline	62-69	synemin	Homo sapiens	17-20
20569464-6	2010	RESULTS: We report that deletion of the C-terminal domain of BMI1, which is rich in proline-serine (PS) residues and previously described as PEST-like domain, increased the stability of BMI1, and promoted its pro-oncogenic activities in human mammary epithelial cells (HMECs).	Proline	84-91	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	61-65
20569464-6	2010	RESULTS: We report that deletion of the C-terminal domain of BMI1, which is rich in proline-serine (PS) residues and previously described as PEST-like domain, increased the stability of BMI1, and promoted its pro-oncogenic activities in human mammary epithelial cells (HMECs).	Proline	84-91	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	186-190
20410294-4	2010	Next, the solution structure of Bem1 SH3b-CI in complex with the proline-rich region of p21-activated kinase Ste20 (Ste20 PRR) was determined.	Proline	65-72	phosphatidylinositol-3-phosphate-binding protein BEM1	Saccharomyces cerevisiae S288C	32-36
20450881-1	2010	In Saccharomyces cerevisiae, the PUT1 and PUT2 genes are required for the conversion of proline to glutamate.	Proline	88-95	proline dehydrogenase	Saccharomyces cerevisiae S288C	33-37
20450881-1	2010	In Saccharomyces cerevisiae, the PUT1 and PUT2 genes are required for the conversion of proline to glutamate.	Proline	88-95	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	42-46
20450881-4	2010	A K(m) value of 36 mM proline and a k(cat)=27 s(-1) were determined for Put1p using an artificial electron acceptor.	Proline	22-29	proline dehydrogenase	Saccharomyces cerevisiae S288C	72-77
20399421-0	2010	Influence of glucose-templated proline mimetics on the beta-turn conformation of the peptide fragment Ac-Leu-D-Phe-Pro-Val-NMe2 found in Gramicidin S. The synthesis of tetrapeptide-based beta-turn mimetics containing spirocyclic glucose-templated 3-hydroxyproline hybrids Glc3"(S)-5"(R)(CH(2)OH)HypH and Glc3"(S)-5"(S)(CH(2)OH)HypH as proline mimetics is presented.	Proline	256-263	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	123-127
20540760-5	2010	Structural comparisons with prolylendopeptidase and DPP4 identify the S1 proline binding site of PRCP.	Proline	73-80	dipeptidyl peptidase 4	Homo sapiens	52-56
20395299-5	2010	Replacement of Val(362) with amino acid residues that disrupt the alpha-helical structure predicted by molecular modeling, such as arginine, glutamate, or phenylalanine, attenuated the stimulatory effects of Cx50 on lens differentiation, whereas replacement with threonine, isoleucine, leucine, or proline, which maintain the structure preserved the function of Cx50.	Proline	298-305	gap junction protein alpha 8	Gallus gallus	208-212
20540760-5	2010	Structural comparisons with prolylendopeptidase and DPP4 identify the S1 proline binding site of PRCP.	Proline	73-80	prolylcarboxypeptidase	Homo sapiens	97-101
20540760-7	2010	PRCP has an extended active-site cleft that can accommodate proline substrates with multiple N-terminal residues.	Proline	60-67	prolylcarboxypeptidase	Homo sapiens	0-4
20378536-10	2010	Nuclear Gln3 localization in proline-grown (nitrogen limited) cells exhibits no requirement for Pph21/22-Tpd3/Cdc55, whereas nuclear Gat1 localization under these conditions is absolutely dependent on Pph21/22-Tpd3/Cdc55.	Proline	29-36	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	8-12
20360009-10	2010	A series of N-terminal deletions identified a 12-amino acid region, Gly(206)-Pro(217), as being required for the rapid recycling of KCa2.3.	Proline	77-80	potassium calcium-activated channel subfamily N member 3	Homo sapiens	132-138
20225202-5	2010	Our results also demonstrated that the NLS (aa 657-781) and proline-rich domain within MORC2 C-terminus were required for the transcriptional repressive role in cancer cells.	Proline	60-67	MORC family CW-type zinc finger 2	Homo sapiens	87-92
20394753-1	2010	We present the crystal structure of an immunoglobulin light-chain-like domain, CTLA-4, as a strand-swapped dimer displaying cis-trans proline isomerisation and native-like hydrogen bonding.	Proline	134-141	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	79-85
20642005-12	2004	A lactam bridge-cyclized alpha-MSH analog, GlyGlu-c[Lys-Nlc-Glu-His-d-Phe-Arg-Trp-Gly-Arg-Pro-Val-Asp] (GlyGlu-CycMSH), was conjugated with DOTA (11).	Proline	90-93	proopiomelanocortin	Homo sapiens	25-34
20516604-1	2010	Prolylcarboxypeptidase (PrCP) is a lysosomal serine carboxypeptidase that cleaves a variety of C-terminal amino acids adjacent to proline and has been implicated in diseases such as hypertension and obesity.	Proline	130-137	prolylcarboxypeptidase	Homo sapiens	0-22
20516604-1	2010	Prolylcarboxypeptidase (PrCP) is a lysosomal serine carboxypeptidase that cleaves a variety of C-terminal amino acids adjacent to proline and has been implicated in diseases such as hypertension and obesity.	Proline	130-137	prolylcarboxypeptidase	Homo sapiens	24-28
20669142-10	2010	Our results showed that, in general, cryopreservation with ectoin led to high post-thaw cell survival of up to 72% whereas after cryopreservation with glycerol and proline, the hMSC cells were completely dead (glycerol) or had only poor cell survival (proline, 22%).	Proline	164-171	musculin	Homo sapiens	177-181
20471275-2	2010	Our previous studies showed that the high-affinity HSP47-binding motif in the collagen triple helix is Xaa-(Thr/Pro)-Gly-Xaa-Arg-Gly.	Proline	112-115	serpin family H member 1	Homo sapiens	51-56
20471275-3	2010	In this study, we further investigated structural requirements for the HSP47-binding motif, using synthetic triple-helical collagen-model peptides with systematic amino acid substitutions at either the Thr/Pro (=Yaa(-3)) or the Arg (=Yaa(0)) position.	Proline	206-209	serpin family H member 1	Homo sapiens	71-76
20374250-5	2010	Through the addition of a proline residue, the new peptide with sequence, CPNGRC, inhibits aminopeptidase N proteolytic activity with an IC(50) of 10 microM, a value that is 30-fold lower than that for CNGRC.	Proline	26-33	alanyl aminopeptidase, membrane	Homo sapiens	91-107
19939229-1	2010	A proline-rich polypeptide complex (PRP), subsequently called Colostrinin(CLN), was first isolated from ovine colostrum, was shown to possess immunoregulatory properties, including effects on the maturation and differentiation of murine thymocytes and humoral and cellular immune responses, both in vivo and in vitro.	Proline	2-9	calmegin	Mus musculus	62-78
19948747-4	2010	Since mutations in the p53 gene are present in approximately 40% of all human lung cancers and are more common in smokers than in nonsmokers, we aimed to detect the status of p53 at codon 72 for Arg/Arg or Arg/Pro or Pro/Pro allele polymorphism and p53 codon 249 mutation in smokers and nonsmokers of South India.	Proline	210-213	tumor protein p53	Homo sapiens	175-178
19948747-4	2010	Since mutations in the p53 gene are present in approximately 40% of all human lung cancers and are more common in smokers than in nonsmokers, we aimed to detect the status of p53 at codon 72 for Arg/Arg or Arg/Pro or Pro/Pro allele polymorphism and p53 codon 249 mutation in smokers and nonsmokers of South India.	Proline	210-213	tumor protein p53	Homo sapiens	175-178
20669142-11	2010	Moreover, the morphology of the hMSC cells changed to a large and flat phenotype after cryopreservation with proline.	Proline	109-116	musculin	Homo sapiens	32-36
20512923-6	2010	Alignment of the cDNA-deduced sequences of serine proteases showed the replacement of an essential serine residue in the catalytic triad of serine proteases by a proline residue in TESPL, which was demonstrated to be a membrane-bound protein devoid of proteolytic activity.	Proline	162-169	protease, serine 45	Mus musculus	181-186
20430752-1	2010	The yeast N-acetyltransferase MPR1 gene has previously been shown to confer resistance to the toxic proline analogue azetidine-2-carboxylic acid (A2C) in yeast and transgenic tobacco.	Proline	100-107	N-acetyltransferase	Saccharomyces cerevisiae S288C	10-29
20430752-1	2010	The yeast N-acetyltransferase MPR1 gene has previously been shown to confer resistance to the toxic proline analogue azetidine-2-carboxylic acid (A2C) in yeast and transgenic tobacco.	Proline	100-107	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	30-34
20512840-3	2010	Actually, polymorphic variants Arg and Pro were found to have different properties of regulation of TP53-dependent DNA repair target genes, that can effect various levels of chromosome aberrations in cancer patients with these genotypes.	Proline	39-42	tumor protein p53	Homo sapiens	100-104
20431603-3	2010	In addition, the SLC6A7 gene, which is positioned at 5q31-32 and encodes the transporter for an excitatory neurotransmitter of L-proline, has never been studied for its association with asthma.	Proline	127-136	solute carrier family 6 member 7	Homo sapiens	17-23
20020325-1	2010	The AGAPEPAEPAQPGVY proline-rich polypeptide (PRP-1) was isolated from neurosecretory granules of the bovine neurohypophysis; it is produced by N. supraopticus and N. paraventricularis.	Proline	20-27	placental prolactin-related protein 1	Bos taurus	46-51
20416277-2	2010	Oxygen- and 2-oxoglutarate (2-OG)-dependent, iron(II) containing HIF-specific prolyl-4-hydroxylases (PHDs) and factor inhibiting HIF-1alpha (FIH-1) catalyze the hydroxylation of the specific proline and asparagine residues of HIF-1alpha, thereby controlling the level of HIF-1alpha and ultimately the HIF response.	Proline	191-198	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
20087764-1	2010	In the present study we carried out experiments in vitro and in vivo and investigated the effect of proline-rich polypeptide (PRP) on the proliferation and effectiveness of colony formation of MMSCs in vitro.	Proline	100-107	proline rich protein 2-like 1	Rattus norvegicus	126-129
20363744-4	2010	P3H1 and CRTAP have previously been shown to form a stable complex with cyclophilin B, and P3H1 was shown to catalyze the 3-hydroxylation of specific proline residues in procollagen I in vitro.	Proline	150-157	prolyl 3-hydroxylase 1	Mus musculus	0-4
20363744-4	2010	P3H1 and CRTAP have previously been shown to form a stable complex with cyclophilin B, and P3H1 was shown to catalyze the 3-hydroxylation of specific proline residues in procollagen I in vitro.	Proline	150-157	cartilage associated protein	Mus musculus	9-14
20363744-4	2010	P3H1 and CRTAP have previously been shown to form a stable complex with cyclophilin B, and P3H1 was shown to catalyze the 3-hydroxylation of specific proline residues in procollagen I in vitro.	Proline	150-157	prolyl 3-hydroxylase 1	Mus musculus	91-95
20442285-6	2010	We also found that TTLL4 expression was correlated with polyglutamylation levels of a glutamate stretch region of the proline, glutamate, and leucine-rich protein 1 (PELP1) that was shown to interact with various proteins such as histone H3, and was involved in several signaling pathways through its function as a scaffold protein.	Proline	118-125	tubulin tyrosine ligase like 4	Homo sapiens	19-24
20471270-5	2010	When a proline in the kinesin-2 neck linker was replaced, kinesin-1 and kinesin-2 run lengths scaled identically with neck linker length, despite moving at different speeds.	Proline	7-14	kinesin family member 2A	Homo sapiens	22-31
20471270-5	2010	When a proline in the kinesin-2 neck linker was replaced, kinesin-1 and kinesin-2 run lengths scaled identically with neck linker length, despite moving at different speeds.	Proline	7-14	kinesin family member 2A	Homo sapiens	72-81
20442285-6	2010	We also found that TTLL4 expression was correlated with polyglutamylation levels of a glutamate stretch region of the proline, glutamate, and leucine-rich protein 1 (PELP1) that was shown to interact with various proteins such as histone H3, and was involved in several signaling pathways through its function as a scaffold protein.	Proline	118-125	proline, glutamate and leucine rich protein 1	Homo sapiens	166-171
20485499-9	2010	These data suggest that both CRTAP and P3H1 are required to maintain a stable complex that 3-hydroxylates canonical proline sites within clade A (types I, II, and V) collagen chains.	Proline	116-123	cartilage associated protein	Mus musculus	29-34
20335506-0	2010	MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans.	Proline	38-45	Uncharacterized protein	Caenorhabditis elegans	0-6
20335506-8	2010	However, the substitution mutation mlt-10(mg364), which disrupts the proline-rich repeats, causes the most severe phenotype.	Proline	69-76	Uncharacterized protein	Caenorhabditis elegans	35-41
20336696-6	2010	Furthermore, an insertion in the serine-threonine-proline rich C-terminal extremity of Hoxa1 induced an increase in activity in mammalian cells as well as in the yeast assay.	Proline	50-57	homeobox A1	Homo sapiens	87-92
20485499-9	2010	These data suggest that both CRTAP and P3H1 are required to maintain a stable complex that 3-hydroxylates canonical proline sites within clade A (types I, II, and V) collagen chains.	Proline	116-123	prolyl 3-hydroxylase 1	Mus musculus	39-43
20485545-6	2010	The JCV P99A tAg is mutated at a conserved proline, which in the SV40 tAg is required for efficient interaction with protein phosphatase 2A (PP2A), and the C157A mutant tAg is altered at one of two newly recognized LxCxE motifs.	Proline	43-50	long intergenic non-protein coding RNA 1194	Homo sapiens	13-16
20485545-6	2010	The JCV P99A tAg is mutated at a conserved proline, which in the SV40 tAg is required for efficient interaction with protein phosphatase 2A (PP2A), and the C157A mutant tAg is altered at one of two newly recognized LxCxE motifs.	Proline	43-50	long intergenic non-protein coding RNA 1194	Homo sapiens	70-73
20485545-6	2010	The JCV P99A tAg is mutated at a conserved proline, which in the SV40 tAg is required for efficient interaction with protein phosphatase 2A (PP2A), and the C157A mutant tAg is altered at one of two newly recognized LxCxE motifs.	Proline	43-50	protein phosphatase 2 phosphatase activator	Homo sapiens	141-145
20485545-6	2010	The JCV P99A tAg is mutated at a conserved proline, which in the SV40 tAg is required for efficient interaction with protein phosphatase 2A (PP2A), and the C157A mutant tAg is altered at one of two newly recognized LxCxE motifs.	Proline	43-50	long intergenic non-protein coding RNA 1194	Homo sapiens	70-73
20212049-7	2010	Furthermore, we showed that deletion of the basic domain enhances, whereas a mutation in activation domains 1-2 and deletion of the proline-rich domain abolish mutant p53 to regulate Gro1 and Id2, both of which are regulated by and mediate endogenous mutant p53 gain of function.	Proline	132-139	tumor protein p53	Homo sapiens	167-170
19935835-6	2010	The rs17368528 SNP results in an amino-acid substitution (proline to leucine) in the fifth exon of the hexose-6-phosphate dehydrogenase (H6PD) gene, in which some variants have been reported to attenuate or abolish H6PD activity, in individuals with cortisone reductase deficiency.	Proline	58-65	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	103-135
20360685-4	2010	We show here that, through its C-terminal proline-rich binding domain (PBD, residues 543-559), AIF associates in the nucleus with histone H2AX.	Proline	42-49	apoptosis inducing factor mitochondria associated 1	Homo sapiens	95-98
20360685-4	2010	We show here that, through its C-terminal proline-rich binding domain (PBD, residues 543-559), AIF associates in the nucleus with histone H2AX.	Proline	42-49	H2A.X variant histone	Homo sapiens	138-142
20404169-7	2010	Release from the clamped conformation is driven by association of syndapin 1 SH3 with the proline-rich domain of dynamin 1, thereby unlocking its potent membrane-bending activity.	Proline	90-97	protein kinase C and casein kinase substrate in neurons 1	Homo sapiens	66-76
20404169-7	2010	Release from the clamped conformation is driven by association of syndapin 1 SH3 with the proline-rich domain of dynamin 1, thereby unlocking its potent membrane-bending activity.	Proline	90-97	dynamin 1	Homo sapiens	113-122
19848449-1	2010	INTRODUCTION: Zein is a hydrophobic corn protein, rich in leucine, proline, and alanine, that has been investigated as an excipient in pharmaceutical formulations, maybe used as a biodegradable/biocompatible material for controlled release formulations.	Proline	67-74	zein	Zea mays	14-18
20212049-5	2010	We also found that activation domains 1-2 and the proline-rich domain are required for mutant p53 gain of function.	Proline	50-57	tumor protein p53	Homo sapiens	94-97
20658010-1	2010	UNLABELLED: p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72.	Proline	111-118	tumor protein p53	Homo sapiens	12-15
20658010-1	2010	UNLABELLED: p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72.	Proline	111-118	tumor protein p53	Homo sapiens	140-143
20658010-1	2010	UNLABELLED: p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72.	Proline	120-123	tumor protein p53	Homo sapiens	12-15
20658010-1	2010	UNLABELLED: p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72.	Proline	120-123	tumor protein p53	Homo sapiens	140-143
20163929-9	2010	Phosphorylation of proline-rich Akt substrate of 40-kDa (PRAS40) at Thr246 was stimulated by IGF-1.	Proline	19-26	AKT serine/threonine kinase 1	Bos taurus	32-35
20163929-9	2010	Phosphorylation of proline-rich Akt substrate of 40-kDa (PRAS40) at Thr246 was stimulated by IGF-1.	Proline	19-26	insulin like growth factor 1	Bos taurus	93-98
19935835-6	2010	The rs17368528 SNP results in an amino-acid substitution (proline to leucine) in the fifth exon of the hexose-6-phosphate dehydrogenase (H6PD) gene, in which some variants have been reported to attenuate or abolish H6PD activity, in individuals with cortisone reductase deficiency.	Proline	58-65	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	137-141
19935835-6	2010	The rs17368528 SNP results in an amino-acid substitution (proline to leucine) in the fifth exon of the hexose-6-phosphate dehydrogenase (H6PD) gene, in which some variants have been reported to attenuate or abolish H6PD activity, in individuals with cortisone reductase deficiency.	Proline	58-65	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	215-219
20194601-2	2010	The C-terminal halves of PspA and PspC have some structural similarity and contain highly cross-reactive proline-rich (PR) regions.	Proline	105-112	surfactant associated protein A1	Mus musculus	25-29
20019240-0	2010	Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis.	Proline	76-83	tumor protein p53	Homo sapiens	40-43
20019240-0	2010	Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis.	Proline	76-83	tumor protein p53	Homo sapiens	98-101
20019240-4	2010	The largest difference between p53-arginine and p53-proline was found with the PERP gene involved in cell-cell adhesion and apoptosis.	Proline	52-59	tumor protein p53	Homo sapiens	48-51
20019240-4	2010	The largest difference between p53-arginine and p53-proline was found with the PERP gene involved in cell-cell adhesion and apoptosis.	Proline	52-59	p53 apoptosis effector related to PMP22	Homo sapiens	79-83
20019240-6	2010	LIF, a cytokine that is required for optimal reproductive function, was produced at 2x higher levels by the p53-arginine than the p53-proline allele.	Proline	134-141	LIF interleukin 6 family cytokine	Homo sapiens	0-3
20019240-6	2010	LIF, a cytokine that is required for optimal reproductive function, was produced at 2x higher levels by the p53-arginine than the p53-proline allele.	Proline	134-141	tumor protein p53	Homo sapiens	130-133
20019240-7	2010	The genes that induced their mRNAs at the highest levels compared to the baseline tended to be synthesized better by the p53-arginine protein than the p53-proline protein.	Proline	155-162	tumor protein p53	Homo sapiens	151-154
20355726-0	2010	Effect of glycosylation on cis/trans isomerization of prolines in IgA1-hinge peptide.	Proline	54-62	immunoglobulin heavy constant alpha 1	Homo sapiens	66-70
20026128-1	2010	Protein kinase C-alpha (PKCalpha) was recently reported to increase myocardial stiffness, an effect that was proposed to be due to phosphorylation of two highly conserved sites (S11878 and S12022) within the proline-glutamic acid-valine-lysine (PEVK) rich spring element of titin.	Proline	208-215	protein kinase C, alpha	Mus musculus	24-32
20346669-3	2010	This is the first mutation event observed in a human GNE allele inducing a proline.	Proline	75-82	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	53-56
20216986-10	2010	Thereby, Ruk/CIN85 interfered with the proline hydroxylation-dependent HIF-1alpha protein destabilisation.	Proline	39-46	SH3 domain containing kinase binding protein 1	Homo sapiens	13-18
20216986-10	2010	Thereby, Ruk/CIN85 interfered with the proline hydroxylation-dependent HIF-1alpha protein destabilisation.	Proline	39-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
20146400-4	2010	Different levels of complementation of cycloheximide hypersensitivity and expression of autoregulated PDR3 and its PDR5 target in the pdr1Deltapdr3Delta mutant strain, ranging from that of the wild-type to loss-of-function alleles, were observed in pdr3 mutants containing Pro, Glu, Arg, Asn, Ser, Leu, Phe, Ile or Tyr instead of Asp853 in Pdr3p.	Proline	273-276	drug-responsive transcription factor PDR3	Saccharomyces cerevisiae S288C	102-106
20146400-4	2010	Different levels of complementation of cycloheximide hypersensitivity and expression of autoregulated PDR3 and its PDR5 target in the pdr1Deltapdr3Delta mutant strain, ranging from that of the wild-type to loss-of-function alleles, were observed in pdr3 mutants containing Pro, Glu, Arg, Asn, Ser, Leu, Phe, Ile or Tyr instead of Asp853 in Pdr3p.	Proline	273-276	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	115-119
20188155-1	2010	Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH(2)) and the structurally related [Glu(2)]TRH (pGlu-Glu-Pro-NH(2)) are endogenous peptides with a plethora of actions in the central nervous system.	Proline	45-48	thyrotropin releasing hormone	Mus musculus	0-29
19694944-5	2010	In contrast, deletion of the juxtamembrane (Leu(150)-Arg(160)) or central (Ala(159)-Pro(170)) intracellular segment of GPIbbeta resulted in a 21% and 23% reduction in the number of cells extending filopodia, respectively.	Proline	84-87	glycoprotein Ib, beta polypeptide	Mus musculus	119-127
20219976-4	2010	Although mitotic Cdk and MAPK may phosphorylate subsets of these motifs that have a basic residue at the +2 position and a proline residue at the -2 position, respectively, the majority of these motifs that are preferentially phosphorylated in mitosis do not have these features.	Proline	123-130	mitogen-activated protein kinase 1 S homeolog	Xenopus laevis	25-29
20593119-9	2010	Hepatocyte growth factor mRNA was more abundant in the HM-Gln group when compared to CM (0.31 vs. 0.23 arbitrary units) and also in HM-Pro in relation to HM-Gln, HN-Pro, and CM(0.46 vs. 0.33 and 0.23, respectively, P&lt;0.05).	Proline	135-138	hepatocyte growth factor	Rattus norvegicus	0-24
20217124-5	2010	The elevated tolerance of the AtCPK6 over-expressing plants was confirmed by the change of proline and malondialdehyde (MDA).	Proline	91-98	Calcium-dependent protein kinase family protein	Arabidopsis thaliana	30-36
20233336-9	2010	TSRF1 also increases the expression of MYB, MYC and proline synthesis and photosynthesis-related genes, probably by binding to dehydration responsive element and GCC boxes in promoters of the target genes.	Proline	52-59	ethylene responsive element binding protein	Solanum lycopersicum	0-5
20143043-1	2010	Delta(1)-pyrroline-5-carboxylate synthetase (P5CS) is the rate-limiting enzyme involved in the biosynthesis of proline in plants.	Proline	111-118	delta-pyrroline-5-carboxylate synthetase	Glycine max	45-49
20173116-5	2010	We also demonstrate a novel and direct interaction between the SH3 domains of Lyn and Src with a conserved proline-rich motif in GMR-alpha and show a selective requirement for Src family kinases by the FIDelta mutant.	Proline	107-114	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	78-81
20173116-5	2010	We also demonstrate a novel and direct interaction between the SH3 domains of Lyn and Src with a conserved proline-rich motif in GMR-alpha and show a selective requirement for Src family kinases by the FIDelta mutant.	Proline	107-114	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	86-89
20173116-5	2010	We also demonstrate a novel and direct interaction between the SH3 domains of Lyn and Src with a conserved proline-rich motif in GMR-alpha and show a selective requirement for Src family kinases by the FIDelta mutant.	Proline	107-114	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	129-138
20403182-2	2010	When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and Pyrroline-5-carboxylate dehydrogenase (P5CDH), which are both mitochondrial enzymes in eukaryotes.	Proline	41-44	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	73-90
20403182-2	2010	When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and Pyrroline-5-carboxylate dehydrogenase (P5CDH), which are both mitochondrial enzymes in eukaryotes.	Proline	41-44	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	92-97
20403182-2	2010	When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and Pyrroline-5-carboxylate dehydrogenase (P5CDH), which are both mitochondrial enzymes in eukaryotes.	Proline	41-44	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	103-140
20403182-2	2010	When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and Pyrroline-5-carboxylate dehydrogenase (P5CDH), which are both mitochondrial enzymes in eukaryotes.	Proline	41-44	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	142-147
20421926-7	2010	In contrast, the expression of two proteins involved in RNA processing, the Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) and the Splicing factor proline/glutamine-rich (SFPQ), was higher in Snail1-expressing cells than in controls.	Proline	166-173	splicing factor proline and glutamine rich	Homo sapiens	190-194
20159969-5	2010	A modified mammalian one-hybrid assay showed that the NH(2)-terminal proline-rich domain of Zimp7 and the region spanning amino acids 321-486 of PIAS3 were the primary interaction segments.	Proline	69-76	zinc finger MIZ-type containing 2	Homo sapiens	92-97
20421926-7	2010	In contrast, the expression of two proteins involved in RNA processing, the Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) and the Splicing factor proline/glutamine-rich (SFPQ), was higher in Snail1-expressing cells than in controls.	Proline	166-173	snail family transcriptional repressor 1	Homo sapiens	211-217
20150423-8	2010	We mapped the preferred calpain cleavage site between the two C-terminal proline-rich regions after Ser-745, resulting in a C-terminal fragment similar in size to the FAK-related non-kinase (FRNK).	Proline	73-80	calpain 2	Homo sapiens	24-31
20150423-8	2010	We mapped the preferred calpain cleavage site between the two C-terminal proline-rich regions after Ser-745, resulting in a C-terminal fragment similar in size to the FAK-related non-kinase (FRNK).	Proline	73-80	protein tyrosine kinase 2	Homo sapiens	191-195
20654103-9	2010	A cross-species alignment of GATA4 encoded protein sequences showed that the valine at amino acid residue 267 and proline at amino acid residue 407 were completely conserved evolutionarily.	Proline	114-121	GATA binding protein 4	Homo sapiens	29-34
20110098-6	2010	In the case of mutant human TRIM5alpha carrying proline at the position 332, however, both HIV-1 and SIVmac restrictions were eliminated as a result of RING domain mutations.	Proline	48-55	tripartite motif containing 5	Homo sapiens	28-38
20159969-5	2010	A modified mammalian one-hybrid assay showed that the NH(2)-terminal proline-rich domain of Zimp7 and the region spanning amino acids 321-486 of PIAS3 were the primary interaction segments.	Proline	69-76	protein inhibitor of activated STAT 3	Homo sapiens	145-150
20437590-3	2010	Screening in subjects with febrile seizures and genetic epilepsy with febrile seizures plus revealed that 2.4% carried a common triple proline deletion (delPPP) in HCN2 that was seen in only 0.2% of blood bank controls.	Proline	135-142	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	164-168
20196616-2	2010	The polypeptide chain of rabbit uterine smMLCK (Swiss-Prot entry P29294) contains the catalytic/regulatory domain, three immunoglobulin-related motifs (Ig), one fibronectin-related motif (Fn3), a repetitive, proline-rich segment (PEVK), and, at the N-terminus, a unique F-actin-binding domain.	Proline	208-215	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	40-46
20150895-4	2010	This steady state, tonic CD3 monoubiquitylation is mediated by the CD3varepsilon proline-rich sequence, Lck, c-Cbl, and SLAP, which collectively trigger the dynamin-dependent downmodulation, lysosomal sequestration and degradation of surface TCR:CD3 complexes.	Proline	81-88	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	242-245
20368803-9	2010	In the docked model of the PPIL1.SKIP interaction, a proline residue of SKIP is buried in a hydrophobic pocket of PPIL1.	Proline	53-60	peptidylprolyl isomerase like 1	Homo sapiens	27-32
20368803-9	2010	In the docked model of the PPIL1.SKIP interaction, a proline residue of SKIP is buried in a hydrophobic pocket of PPIL1.	Proline	53-60	peptidylprolyl isomerase like 1	Homo sapiens	114-119
19885922-2	2010	For both pSer-Pro and pThr-Pro peptides in the gas phase and in chloroform, the most preferred conformation has the alpha-helical structure for the pSer/pThr residue, the down-puckered polyproline I structure for the Pro residue, and the cis prolyl peptide bond between the two residues, in which two hydrogen bonds between the phosphate oxygens with the backbone N--H groups seem to play a role.	Proline	14-17	parathyroid hormone 1 receptor	Homo sapiens	153-157
20406072-3	2010	DPP IV removes the two amino-terminal amino acids (Ser and Pro) from BNP(1-32) to produce BNP(3-32), which has been detected in plasma of patients with heart failure.	Proline	59-62	dipeptidyl peptidase 4	Homo sapiens	0-6
20406072-3	2010	DPP IV removes the two amino-terminal amino acids (Ser and Pro) from BNP(1-32) to produce BNP(3-32), which has been detected in plasma of patients with heart failure.	Proline	59-62	natriuretic peptide B	Homo sapiens	69-72
20406072-3	2010	DPP IV removes the two amino-terminal amino acids (Ser and Pro) from BNP(1-32) to produce BNP(3-32), which has been detected in plasma of patients with heart failure.	Proline	59-62	natriuretic peptide B	Homo sapiens	90-93
20202843-1	2010	Brain-penetrable proline amides were developed as 5HT2c agonists with more than 1000-fold binding selectivity against 5HT2b receptor.	Proline	17-24	5-hydroxytryptamine receptor 2C	Homo sapiens	50-55
20202843-1	2010	Brain-penetrable proline amides were developed as 5HT2c agonists with more than 1000-fold binding selectivity against 5HT2b receptor.	Proline	17-24	5-hydroxytryptamine receptor 2B	Homo sapiens	118-132
20207139-2	2010	The initial loss in potency of carboxylate analogs was likely due to weaker charge-charge interactions in the putative phosphate binding pocket and was subsequently recovered by structure-based optimization of ligand-protein interactions in the proline binding site, leading to the discovery of a sub-micromolar non-phosphate small molecular Pin1 inhibitor.	Proline	245-252	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	342-346
19885922-6	2010	The calculated cis populations of 14.7 and 14.2% and rotational barriers of 19.87 and 20.57 kcal/mol to the cis-to-trans isomerization for pSer-Pro and pThr-Pro peptides in water, respectively, are consistent with the observed values for pSer-Pro and pThr-Pro containing peptides from NMR experiments.	Proline	144-147	parathyroid hormone 1 receptor	Homo sapiens	251-255
19526339-8	2010	We show that two alleles containing a proline substitution in Helix 12 that inactivate AF-2 function of ERalpha at EREs have little negative effect on function through AP-1 elements, supporting a prominent role for the N-terminal AF-1 of ERalpha in AP-1/ERalpha transcriptional cross talk.	Proline	38-45	estrogen receptor 1	Homo sapiens	104-111
19930425-8	2010	Another group of rats were killed on Days 7 and 14 after balloon injury for the analysis of in vitro collagen synthesis and secretion with U-II treated by [(3)H]-proline incorporation and determination of [(3)H]-hydroxyproline radioactivity, respectively.	Proline	162-169	urotensin 2	Rattus norvegicus	139-143
20123155-6	2010	Several revertant T-cell clones expressed an internally deleted WASp mutant lacking much of the proline-rich region.	Proline	96-103	WASP actin nucleation promoting factor	Homo sapiens	64-68
20074566-12	2010	In conclusion, system A, most likely ATA2, is responsible for the retina-to-blood transport of l-proline across the inner BRB and may play a role in maintaining the concentration of small neutral amino acids in the retina.	Proline	95-104	solute carrier family 38, member 2	Rattus norvegicus	37-41
19526339-8	2010	We show that two alleles containing a proline substitution in Helix 12 that inactivate AF-2 function of ERalpha at EREs have little negative effect on function through AP-1 elements, supporting a prominent role for the N-terminal AF-1 of ERalpha in AP-1/ERalpha transcriptional cross talk.	Proline	38-45	estrogen receptor 1	Homo sapiens	238-245
19526339-8	2010	We show that two alleles containing a proline substitution in Helix 12 that inactivate AF-2 function of ERalpha at EREs have little negative effect on function through AP-1 elements, supporting a prominent role for the N-terminal AF-1 of ERalpha in AP-1/ERalpha transcriptional cross talk.	Proline	38-45	estrogen receptor 1	Homo sapiens	238-245
20357999-7	2010	There were three types of TGF-beta1 gene polymorphism at codon 10: proline homozygous (P/P), proline/leucine heterozygous (P/L), and leucine homozygous (L/L) genotype.	Proline	67-74	transforming growth factor beta 1	Homo sapiens	26-35
20345904-6	2010	With respect to the cleavage site specificities, the study revealed that all three MMPs similarly tolerate hydrophobic and/or aliphatic amino acids, including Pro, Gly, Ile, and Val, at P(1)".	Proline	159-162	matrix metallopeptidase 7	Homo sapiens	83-87
20172963-0	2010	Mutations in the hyperosmotic stress-responsive mitochondrial BASIC AMINO ACID CARRIER2 enhance proline accumulation in Arabidopsis.	Proline	96-103	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	62-87
20064647-0	2010	Misincorporation of the proline homologue Aze (azetidine-2-carboxylic acid) into recombinant myelin basic protein.	Proline	24-31	myelin basic protein	Mus musculus	93-113
20064647-1	2010	We have evaluated the effects of the proline homologue Aze (1) (azetidine-2-carboxylic acid) on growth of Escherichia coli strains used to over-express recombinant forms of murine myelin basic protein (rmMBP), and on the degree of misincorporation.	Proline	37-44	myelin basic protein	Mus musculus	180-200
19911250-11	2010	Then, since the introduction of a proline in the last domain of titin was previously known to cause TMD in French families, we can conclude that this missense mutation is the obvious pathogenetic mutation in the affected patients.	Proline	34-41	titin	Homo sapiens	64-69
20172963-7	2010	Under hyperosmotic stress, bac2 mutants express the P5CS1 proline biosynthetic gene more strongly than the wild type, and this correlates with a greater accumulation of Pro.	Proline	58-65	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	27-31
20172963-7	2010	Under hyperosmotic stress, bac2 mutants express the P5CS1 proline biosynthetic gene more strongly than the wild type, and this correlates with a greater accumulation of Pro.	Proline	58-65	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	52-57
20110360-8	2010	Interestingly, unlike cdc2, BGLF4 was shown to phosphorylate non-proline directed serine residues of stathmin (Ser-16) and it mediated phosphorylation of stathmin predominantly at serines 16, 25, and 38, indicating that BGLF4 can down-regulate the activity of stathmin.	Proline	65-72	tegument serine/threonine protein kinase	Human gammaherpesvirus 4	28-33
20172963-8	2010	Our data suggest that BAC2 is a hyperosmotic stress-inducible transporter of basic amino acids that contributes to proline accumulation in response to hyperosmotic stress in Arabidopsis.	Proline	115-122	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	22-26
19995334-6	2010	Mouse Dock5 (mDock5) is structurally similar to DOCK1 and composed of 1868 amino acids containing Src homology 3 (SH3), DHR1, DHR2, and a proline-rich (PR) motif.	Proline	138-145	dedicator of cytokinesis 5	Mus musculus	6-11
19995334-6	2010	Mouse Dock5 (mDock5) is structurally similar to DOCK1 and composed of 1868 amino acids containing Src homology 3 (SH3), DHR1, DHR2, and a proline-rich (PR) motif.	Proline	138-145	dedicator of cytokinesis 5	Mus musculus	13-19
19951310-9	2010	CONCLUSION: The low prevalence Rh antigen, Be(a), is associated with a single nucleotide change in exon 5 of RHCE*ce; that of 662C&gt;G and this change is predicted to alter proline at amino acid position 221 of Rhce to arginine.	Proline	174-181	Rh blood group CcEe antigens	Homo sapiens	109-113
19951310-9	2010	CONCLUSION: The low prevalence Rh antigen, Be(a), is associated with a single nucleotide change in exon 5 of RHCE*ce; that of 662C&gt;G and this change is predicted to alter proline at amino acid position 221 of Rhce to arginine.	Proline	174-181	Rh blood group CcEe antigens	Homo sapiens	212-216
20334523-2	2010	In this pilot case-control study, we tested the association between TGFB1 T869C codon 10 Leu/Pro (rs1982073), XRCC1 G28152A codon 399 Arg/Gln (rs25487), and XRCC3 C18067T codon 241 Thr/Met (rs861539) single-nucleotide polymorphisms (SNPs) and late reaction to radiotherapy in 60 nasopharyngeal cancer patients.	Proline	93-96	transforming growth factor beta 1	Homo sapiens	68-73
20383038-2	2010	Prolidase is an enzyme that catalyzes the final step of collagen breakdown by liberating free proline for collagen recycling.	Proline	94-101	peptidase D	Homo sapiens	0-9
20178363-7	2010	The sequences of these DPP4 peptide substrates support a broad role for DPP4 in proline-containing peptide catabolism and strengthen a biochemical model that interlinks aminopeptidase and DPP4 activities.	Proline	80-87	dipeptidylpeptidase 4	Mus musculus	23-27
20155951-6	2010	A cluster of histidine and proline residues (His98-Pro99-His100-Pro101-His102) in kappa-casein binds to the C-terminal domain of the protein, where a neighboring conserved arginine residue (Arg97) is found to be important for stabilizing the binding pose.	Proline	27-34	casein kappa	Bos taurus	82-94
20178363-7	2010	The sequences of these DPP4 peptide substrates support a broad role for DPP4 in proline-containing peptide catabolism and strengthen a biochemical model that interlinks aminopeptidase and DPP4 activities.	Proline	80-87	dipeptidylpeptidase 4	Mus musculus	72-76
20178363-7	2010	The sequences of these DPP4 peptide substrates support a broad role for DPP4 in proline-containing peptide catabolism and strengthen a biochemical model that interlinks aminopeptidase and DPP4 activities.	Proline	80-87	dipeptidylpeptidase 4	Mus musculus	72-76
20106972-0	2010	Mechanism for the selective interaction of C-terminal Eps15 homology domain proteins with specific Asn-Pro-Phe-containing partners.	Proline	103-106	epidermal growth factor receptor pathway substrate 15	Homo sapiens	54-59
20064523-8	2010	Furthermore, exchange of proline residues within the putative Src homology 3 binding motifs altered the export of RASSF5 from the nucleus despite the presence of functional NES, suggesting that multiple domains independently modulate the nucleocytoplasmic transport of RASSF5.	Proline	25-32	Ras association domain family member 5	Homo sapiens	114-120
20064523-8	2010	Furthermore, exchange of proline residues within the putative Src homology 3 binding motifs altered the export of RASSF5 from the nucleus despite the presence of functional NES, suggesting that multiple domains independently modulate the nucleocytoplasmic transport of RASSF5.	Proline	25-32	Ras association domain family member 5	Homo sapiens	269-275
20237263-5	2010	HRD1 colocalized with APP in brain neurons and interacted with APP through the proline-rich region of HRD1.	Proline	79-86	synoviolin 1	Homo sapiens	0-4
20237263-5	2010	HRD1 colocalized with APP in brain neurons and interacted with APP through the proline-rich region of HRD1.	Proline	79-86	synoviolin 1	Homo sapiens	102-106
20179103-5	2010	However, only active Mek2 could bind Pin1, acting as a scaffold to bridge Pin1 and BPGAP1 in a manner that involves the release of an autoinhibited proline-rich motif, 186-PPLP-189, proximal to the RhoGAP domain.	Proline	148-155	mitogen-activated protein kinase kinase 2	Homo sapiens	21-25
20305788-6	2010	In addition, TSAd"s ability to promote CXCL12-induced actin polymerization and migration of Jurkat T lymphocytes was dependent on the Itk-interaction site in the proline-rich region of TSAd.	Proline	162-169	SH2 domain containing 2A	Homo sapiens	13-17
20305788-6	2010	In addition, TSAd"s ability to promote CXCL12-induced actin polymerization and migration of Jurkat T lymphocytes was dependent on the Itk-interaction site in the proline-rich region of TSAd.	Proline	162-169	C-X-C motif chemokine ligand 12	Homo sapiens	39-45
20305788-6	2010	In addition, TSAd"s ability to promote CXCL12-induced actin polymerization and migration of Jurkat T lymphocytes was dependent on the Itk-interaction site in the proline-rich region of TSAd.	Proline	162-169	IL2 inducible T cell kinase	Homo sapiens	134-137
20305788-6	2010	In addition, TSAd"s ability to promote CXCL12-induced actin polymerization and migration of Jurkat T lymphocytes was dependent on the Itk-interaction site in the proline-rich region of TSAd.	Proline	162-169	SH2 domain containing 2A	Homo sapiens	185-189
20097748-0	2010	The proline-rich N-terminal domain of G18 exhibits a novel G protein regulatory function.	Proline	4-11	G protein signaling modulator 3	Homo sapiens	38-41
20179103-5	2010	However, only active Mek2 could bind Pin1, acting as a scaffold to bridge Pin1 and BPGAP1 in a manner that involves the release of an autoinhibited proline-rich motif, 186-PPLP-189, proximal to the RhoGAP domain.	Proline	148-155	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	37-41
20179103-5	2010	However, only active Mek2 could bind Pin1, acting as a scaffold to bridge Pin1 and BPGAP1 in a manner that involves the release of an autoinhibited proline-rich motif, 186-PPLP-189, proximal to the RhoGAP domain.	Proline	148-155	Rho GTPase activating protein 8	Homo sapiens	83-89
20179103-6	2010	This allows the non-canonical 186-PPLP-189 and 256-DDYGD-260 motifs of the proline-rich region and RhoGAP domain of BPGAP1 to become accessible to concerted binding by the WW and PPI domains of Pin1, respectively.	Proline	75-82	Rho GTPase activating protein 8	Homo sapiens	116-122
20179103-6	2010	This allows the non-canonical 186-PPLP-189 and 256-DDYGD-260 motifs of the proline-rich region and RhoGAP domain of BPGAP1 to become accessible to concerted binding by the WW and PPI domains of Pin1, respectively.	Proline	75-82	peptidylprolyl isomerase like 1	Homo sapiens	179-182
20179103-6	2010	This allows the non-canonical 186-PPLP-189 and 256-DDYGD-260 motifs of the proline-rich region and RhoGAP domain of BPGAP1 to become accessible to concerted binding by the WW and PPI domains of Pin1, respectively.	Proline	75-82	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	194-198
20221403-7	2010	CIN85 contains three SH3 domains that specifically bind a unique proline-arginine motif (PXXXPR) found in several CIN85 effectors.	Proline	65-72	SH3 domain containing kinase binding protein 1	Homo sapiens	0-5
20143840-5	2010	Through molecular modeling, we describe a possible interaction between HDAC7 proline 809, a residue that is strictly conserved within class 2 enzymes only, and the amide group of HDACi, while nuclear magnetic resonance experiments indicated that dimethyl m-substitution may stabilize the inhibitor in the active site.	Proline	77-84	histone deacetylase 7	Homo sapiens	71-76
20221403-7	2010	CIN85 contains three SH3 domains that specifically bind a unique proline-arginine motif (PXXXPR) found in several CIN85 effectors.	Proline	65-72	SH3 domain containing kinase binding protein 1	Homo sapiens	114-119
22371723-6	2010	There was a highly significant statistical difference in FEV(1)% of predicted associated with the distribution of TGF-beta1 gene genotypes: 56.9 +-8.4% with Pro-Leu genotype and 35.5 +-8.8% with Leu-Leu genotype in COPD patients, 93.2 +-6.2% with Pro-Leu genotype and 86.7 +-0.9% with Leu-Leu genotype in the resistant smokers group.	Proline	157-160	transforming growth factor beta 1	Homo sapiens	114-123
19333719-4	2010	Ion-replacement studies and experiments assessing substrate specificities for both systems provided strong evidence that SNAT2, that showed two- to threefold increased mRNA levels, is the responsible transporter mediating the increased proline influx under conditions of amino acid deprivation.	Proline	236-243	solute carrier family 38 member 2	Homo sapiens	121-126
20356461-2	2010	The ectopic expression of p104 reduced cellular growth rate, which was also achieved with the overexpression of only the proline-rich region of p104.	Proline	121-128	natural killer cell triggering receptor	Homo sapiens	26-30
20356461-2	2010	The ectopic expression of p104 reduced cellular growth rate, which was also achieved with the overexpression of only the proline-rich region of p104.	Proline	121-128	natural killer cell triggering receptor	Homo sapiens	144-148
20356461-3	2010	The proline-rich region of p104 has been found to inhibit the colony formation of platelet-derived growth factor BB-stimulated NIH3T3 cells and MCF7 cancer cells on soft agar.	Proline	4-11	natural killer cell triggering receptor	Homo sapiens	27-31
20356461-4	2010	Mutagenesis analysis showed that the second and third proline-rich regions are essential for growth control, as well as for interaction with p85alpha.	Proline	54-61	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	141-149
20236041-8	2010	The doublecortin-like kinase 1 gene in particular, produces splice variants with different protein domains such as doublecortin-domains, a serine, threonine and proline-rich domain and a serine/threonine kinase-domain.	Proline	161-168	doublecortin like kinase 1	Homo sapiens	4-30
20193851-1	2010	Polymorphism at codon 72 of TP53, resulting in either the arginine (Arg) or proline (Pro) form of p53 (R72P), has been associated with the susceptibility to different cancers.	Proline	76-83	tumor protein p53	Homo sapiens	28-32
20193851-1	2010	Polymorphism at codon 72 of TP53, resulting in either the arginine (Arg) or proline (Pro) form of p53 (R72P), has been associated with the susceptibility to different cancers.	Proline	76-83	tumor protein p53	Homo sapiens	98-101
20193851-1	2010	Polymorphism at codon 72 of TP53, resulting in either the arginine (Arg) or proline (Pro) form of p53 (R72P), has been associated with the susceptibility to different cancers.	Proline	85-88	tumor protein p53	Homo sapiens	28-32
20193851-1	2010	Polymorphism at codon 72 of TP53, resulting in either the arginine (Arg) or proline (Pro) form of p53 (R72P), has been associated with the susceptibility to different cancers.	Proline	85-88	tumor protein p53	Homo sapiens	98-101
19779492-2	2010	We created a mouse model (mDeltapro) that lacked residues 58-88 of the proline-rich domain of p53.	Proline	71-78	transformation related protein 53, pseudogene	Mus musculus	94-97
20236041-8	2010	The doublecortin-like kinase 1 gene in particular, produces splice variants with different protein domains such as doublecortin-domains, a serine, threonine and proline-rich domain and a serine/threonine kinase-domain.	Proline	161-168	doublecortin	Homo sapiens	4-16
19834130-1	2010	Prolidase is a cytosolic exopeptidase that cleaves iminodipeptides with carboxy-terminal proline or hydroxyproline and plays a major role in collagen turnover.	Proline	89-96	peptidase D	Homo sapiens	0-9
20089795-3	2010	We have previously addressed the cross-reactivity of antibodies against PspA fragments containing the N-terminal and proline-rich regions of PspA from clades 1 to 5 (PspA1, PspA2, PspA3, PspA4, and PspA5) by Western blot analysis and reported that anti-PspA4 and anti-PspA5 were able to recognize pneumococci expressing PspA proteins from all of the clades analyzed.	Proline	117-124	surfactant associated protein A1	Mus musculus	72-76
20089795-3	2010	We have previously addressed the cross-reactivity of antibodies against PspA fragments containing the N-terminal and proline-rich regions of PspA from clades 1 to 5 (PspA1, PspA2, PspA3, PspA4, and PspA5) by Western blot analysis and reported that anti-PspA4 and anti-PspA5 were able to recognize pneumococci expressing PspA proteins from all of the clades analyzed.	Proline	117-124	surfactant associated protein A1	Mus musculus	141-145
20089795-3	2010	We have previously addressed the cross-reactivity of antibodies against PspA fragments containing the N-terminal and proline-rich regions of PspA from clades 1 to 5 (PspA1, PspA2, PspA3, PspA4, and PspA5) by Western blot analysis and reported that anti-PspA4 and anti-PspA5 were able to recognize pneumococci expressing PspA proteins from all of the clades analyzed.	Proline	117-124	surfactant associated protein A1	Mus musculus	141-145
20089795-8	2010	We have also analyzed the contribution of the nonproline (NonPro) block within the conserved proline-rich region to the reactivity of anti-PspA antibodies, and the results indicate that N-terminal alpha-helical region, the blocks of proline repeats, and the NonPro region can influence the degree of cross-reactivity of antibodies to PspA.	Proline	49-56	surfactant associated protein A1	Mus musculus	139-143
20089795-8	2010	We have also analyzed the contribution of the nonproline (NonPro) block within the conserved proline-rich region to the reactivity of anti-PspA antibodies, and the results indicate that N-terminal alpha-helical region, the blocks of proline repeats, and the NonPro region can influence the degree of cross-reactivity of antibodies to PspA.	Proline	93-100	surfactant associated protein A1	Mus musculus	139-143
20014005-1	2010	Recent studies implicate that the estrogen receptor (ER) coregulator proline-, glutamic acid-, and leucine-rich protein (PELP) 1 as playing critical roles in ER-genomic, ER-nongenomic, and ER-signaling cross talk with growth factor signaling pathways.	Proline	69-76	estrogen receptor 1	Homo sapiens	34-51
20014005-1	2010	Recent studies implicate that the estrogen receptor (ER) coregulator proline-, glutamic acid-, and leucine-rich protein (PELP) 1 as playing critical roles in ER-genomic, ER-nongenomic, and ER-signaling cross talk with growth factor signaling pathways.	Proline	69-76	estrogen receptor 1	Homo sapiens	53-55
20014005-1	2010	Recent studies implicate that the estrogen receptor (ER) coregulator proline-, glutamic acid-, and leucine-rich protein (PELP) 1 as playing critical roles in ER-genomic, ER-nongenomic, and ER-signaling cross talk with growth factor signaling pathways.	Proline	69-76	estrogen receptor 1	Homo sapiens	158-160
20014005-1	2010	Recent studies implicate that the estrogen receptor (ER) coregulator proline-, glutamic acid-, and leucine-rich protein (PELP) 1 as playing critical roles in ER-genomic, ER-nongenomic, and ER-signaling cross talk with growth factor signaling pathways.	Proline	69-76	estrogen receptor 1	Homo sapiens	158-160
20014005-1	2010	Recent studies implicate that the estrogen receptor (ER) coregulator proline-, glutamic acid-, and leucine-rich protein (PELP) 1 as playing critical roles in ER-genomic, ER-nongenomic, and ER-signaling cross talk with growth factor signaling pathways.	Proline	69-76	estrogen receptor 1	Homo sapiens	158-160
20179161-3	2010	The phosphorylation of proteins on the serine or threonine residues that immediately precede proline (pSer/Thr-Pro) is specifically catalyzed by the prolyl isomerase Pin1 and is a key signaling mechanism in cell proliferation and transformation.	Proline	93-100	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	166-170
20179356-7	2010	Consistent with a role for XPNPEP3 in ciliary function, several ciliary cystogenic proteins were found to be XPNPEP3 substrates, for which resistance to N-terminal proline cleavage resulted in attenuated protein function in vivo in zebrafish.	Proline	164-171	X-prolyl aminopeptidase 3, mitochondrial	Danio rerio	27-34
20179356-7	2010	Consistent with a role for XPNPEP3 in ciliary function, several ciliary cystogenic proteins were found to be XPNPEP3 substrates, for which resistance to N-terminal proline cleavage resulted in attenuated protein function in vivo in zebrafish.	Proline	164-171	X-prolyl aminopeptidase 3, mitochondrial	Danio rerio	109-116
19968759-8	2010	Comparison of the cleavage sites affected by the absence of PC2 confirms previous suggestions that sequences with a Trp, Tyr, and/or Pro in the P1" or P2" position are preferentially cleaved by PC2 and not by other enzymes present in the secretory pathway.	Proline	133-136	proprotein convertase subtilisin/kexin type 2	Mus musculus	60-63
19968759-8	2010	Comparison of the cleavage sites affected by the absence of PC2 confirms previous suggestions that sequences with a Trp, Tyr, and/or Pro in the P1" or P2" position are preferentially cleaved by PC2 and not by other enzymes present in the secretory pathway.	Proline	133-136	proprotein convertase subtilisin/kexin type 2	Mus musculus	194-197
20386644-5	2010	A prion protein gene (PRNP) analysis revealed a P102L (proline-to-leucine) mutation in codon 102.	Proline	55-62	prion protein	Homo sapiens	22-26
19508199-1	2010	he photo-switchable insect kinin thioxo-analog Phe(1)-Tyr(2)-Psi[CS-N]-Pro(3)-Trp(4)-Gly(5)-NH(2) (Psi[CS-N](2)-Kinin) can change from ground state to photo-stationary state by following a pulse of UV Radiation and its bioactivity increases simultaneously.	Proline	71-74	transient receptor potential cation channel subfamily C member 4	Homo sapiens	78-83
19941154-5	2010	Through expression analyses of putative downstream genes in the transgenic plants, we found that the expression levels of two ion antiporter genes AtNHX1 and AtCLCa, a key gene involved in the biosynthesis of proline, AtP5CS, and the copper chaperone for superoxide dismutase gene AtCCS, were all increased significantly in the transgenic plants.	Proline	209-216	Na+/H+ exchanger 1	Arabidopsis thaliana	147-153
19941154-5	2010	Through expression analyses of putative downstream genes in the transgenic plants, we found that the expression levels of two ion antiporter genes AtNHX1 and AtCLCa, a key gene involved in the biosynthesis of proline, AtP5CS, and the copper chaperone for superoxide dismutase gene AtCCS, were all increased significantly in the transgenic plants.	Proline	209-216	chloride channel A	Arabidopsis thaliana	158-164
19800002-5	2010	Recent studies from our laboratory suggested that PELP1 (Proline, Glutamic acid, Leucine rich Protein 1), a novel ER-coregulator, functions as a potential proto-oncogene and promotes tumor growth in nude mice models without exogenous E2 supplementation.	Proline	57-64	proline, glutamic acid and leucine rich protein 1	Mus musculus	50-55
20022081-4	2010	FXII is a multidomain protein that contains two fibronectin binding consensual sequences, two epidermal growth factor regions, a kringle region, a proline-rich domain, and a catalytic domain that when proteolyzed turns into a plasma serine protease.	Proline	147-154	coagulation factor XII (Hageman factor)	Mus musculus	0-4
19948731-10	2010	Truncation experiments combined with simulations suggest that the N-terminal proline-rich domain of apoA-I influences the stability of PL-rich HDL particles.	Proline	77-84	apolipoprotein A1	Homo sapiens	100-106
20038578-2	2010	Numb is an intrinsic regulator of the Notch pathway and exists in four alternative splice variants that differ in the length of their phosphotyrosine-binding domain (PTB) and proline-rich region domains.	Proline	175-182	NUMB, endocytic adaptor protein	Rattus norvegicus	0-4
20007715-2	2010	Here we demonstrate that a conserved proline, Pro(247), in TM6 of platelet-activating factor receptor (PAFR) is required for endoplasmic reticulum (ER) export and trafficking after agonist-induced internalization.	Proline	37-44	platelet activating factor receptor	Homo sapiens	66-101
20007715-2	2010	Here we demonstrate that a conserved proline, Pro(247), in TM6 of platelet-activating factor receptor (PAFR) is required for endoplasmic reticulum (ER) export and trafficking after agonist-induced internalization.	Proline	37-44	platelet activating factor receptor	Homo sapiens	103-107
20007715-2	2010	Here we demonstrate that a conserved proline, Pro(247), in TM6 of platelet-activating factor receptor (PAFR) is required for endoplasmic reticulum (ER) export and trafficking after agonist-induced internalization.	Proline	46-49	platelet activating factor receptor	Homo sapiens	66-101
20007715-2	2010	Here we demonstrate that a conserved proline, Pro(247), in TM6 of platelet-activating factor receptor (PAFR) is required for endoplasmic reticulum (ER) export and trafficking after agonist-induced internalization.	Proline	46-49	platelet activating factor receptor	Homo sapiens	103-107
20007715-8	2010	These results demonstrate that the conserved proline in TM6 is crucial for intracellular trafficking of PAFR.	Proline	45-52	platelet activating factor receptor	Homo sapiens	104-108
19944064-5	2010	Compressibility of the heme pocket in variants of all four CYP2B enzymes containing proline at position 334 are characterized by lower compressibility than their more stable serine 334 counterpart.	Proline	84-91	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	59-64
20159111-7	2010	One of these variants was an alanine-to-proline substitution in the transmembrane 4 superfamily member 12 protein, encoded by TSPAN12.	Proline	40-47	tetraspanin 12	Homo sapiens	68-105
20008323-7	2010	Before the formation of TJs, ZO-1 interacted with afadin through the two proline-rich regions of afadin and the SH3 domain of ZO-1.	Proline	73-80	tight junction protein 1	Canis lupus familiaris	29-33
20008323-7	2010	Before the formation of TJs, ZO-1 interacted with afadin through the two proline-rich regions of afadin and the SH3 domain of ZO-1.	Proline	73-80	afadin, adherens junction formation factor	Canis lupus familiaris	50-56
20159111-7	2010	One of these variants was an alanine-to-proline substitution in the transmembrane 4 superfamily member 12 protein, encoded by TSPAN12.	Proline	40-47	tetraspanin 12	Homo sapiens	126-133
20161733-5	2010	In the current study, we took advantage of intrinsic proline-glycine (Pro-Gly) dipeptides encoded in predicted DAT extracellular domains to introduce tetraCys motifs into DAT extracellular loops 2, 3, and 4.	Proline	53-60	solute carrier family 6 member 3	Rattus norvegicus	111-114
20169205-7	2010	Utilizing tandem mass spectrometry, we identified a number of novel phosphorylation sites in raptor, and using phospho-specific antibodies demonstrated that raptor becomes phosphorylated on phospho-serine/threonine-proline sites in mitosis.	Proline	215-222	regulatory associated protein of MTOR complex 1	Homo sapiens	93-99
20169205-7	2010	Utilizing tandem mass spectrometry, we identified a number of novel phosphorylation sites in raptor, and using phospho-specific antibodies demonstrated that raptor becomes phosphorylated on phospho-serine/threonine-proline sites in mitosis.	Proline	215-222	regulatory associated protein of MTOR complex 1	Homo sapiens	157-163
20161733-5	2010	In the current study, we took advantage of intrinsic proline-glycine (Pro-Gly) dipeptides encoded in predicted DAT extracellular domains to introduce tetraCys motifs into DAT extracellular loops 2, 3, and 4.	Proline	53-60	solute carrier family 6 member 3	Rattus norvegicus	171-174
19616076-2	2010	Within the 15-member galectin family of proteins, Gal3 (M(r) approximately 30,000) is the sole representative of the chimera subclass in which a proline- and glycine-rich NH(2)-terminal domain is fused onto a COOH-terminal carbohydrate recognition domain responsible for binding galactose-containing glycoconjugates.	Proline	145-152	galectin 3	Homo sapiens	50-54
20047279-9	2010	From this library, we found an improved clone, scFv#m2-c4 (K(a) = 6.3 x 10(8) M(-1); Lys(H19)Arg, Tyr(H56)Phe, Ser(H84)Pro, Glu(H85)Gly, Gln(L27)Arg, Leu(L36)Met, Ser(L63)Gly, and Ser(L77)Gly).	Proline	119-122	immunglobulin heavy chain variable region	Homo sapiens	47-51
19609526-0	2010	HbA2-Partinico or delta(A2)Pro-->Thr, a new genetic variation in the delta-globin gene in cis to the beta(+) thal IVS-I-110 G>A, and the heterogeneity of delta-globin alleles in double heterozygotes for beta- and delta-globin gene defects.	Proline	27-30	hemoglobin subunit delta	Homo sapiens	69-81
19609526-0	2010	HbA2-Partinico or delta(A2)Pro-->Thr, a new genetic variation in the delta-globin gene in cis to the beta(+) thal IVS-I-110 G>A, and the heterogeneity of delta-globin alleles in double heterozygotes for beta- and delta-globin gene defects.	Proline	27-30	hemoglobin subunit delta	Homo sapiens	154-166
19609526-0	2010	HbA2-Partinico or delta(A2)Pro-->Thr, a new genetic variation in the delta-globin gene in cis to the beta(+) thal IVS-I-110 G>A, and the heterogeneity of delta-globin alleles in double heterozygotes for beta- and delta-globin gene defects.	Proline	27-30	hemoglobin subunit beta	Homo sapiens	203-225
19609526-6	2010	The new variant delta5(A2)Pro-->Thr, named HbA2-Partinico upon the origin of the family, was detected with high-performance liquid chromatography; it overlapped the HbA2 peak which was partially split.	Proline	26-29	hemoglobin subunit alpha 2	Homo sapiens	43-47
19609526-6	2010	The new variant delta5(A2)Pro-->Thr, named HbA2-Partinico upon the origin of the family, was detected with high-performance liquid chromatography; it overlapped the HbA2 peak which was partially split.	Proline	26-29	hemoglobin subunit alpha 2	Homo sapiens	165-169
19966180-0	2010	Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells.	Proline	27-34	iodothyronine deiodinase 2	Homo sapiens	59-90
20042335-1	2010	We substituted a truncated neuropeptide Y (NPY) analog, [Pro(30), Tyr(32), Leu(34)]NPY(28-36)NH(2) also called BVD15, at various positions with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7-10-tetraacetic acid) and evaluated the effect of the coupling position with the binding affinity for NPY Y(1) receptors (NPY1R).	Proline	57-60	neuropeptide Y	Homo sapiens	27-41
20042335-1	2010	We substituted a truncated neuropeptide Y (NPY) analog, [Pro(30), Tyr(32), Leu(34)]NPY(28-36)NH(2) also called BVD15, at various positions with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7-10-tetraacetic acid) and evaluated the effect of the coupling position with the binding affinity for NPY Y(1) receptors (NPY1R).	Proline	57-60	neuropeptide Y	Homo sapiens	43-46
20042335-1	2010	We substituted a truncated neuropeptide Y (NPY) analog, [Pro(30), Tyr(32), Leu(34)]NPY(28-36)NH(2) also called BVD15, at various positions with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7-10-tetraacetic acid) and evaluated the effect of the coupling position with the binding affinity for NPY Y(1) receptors (NPY1R).	Proline	57-60	neuropeptide Y	Homo sapiens	83-86
19884823-2	2010	Research has mainly focused on isoleucine-proline-proline and valine-proline-proline (IPP + VPP), two lactotripeptides that can inhibit the angiotensin-converting enzyme (ACE) in vitro.	Proline	42-49	angiotensin I converting enzyme	Homo sapiens	140-169
19884823-2	2010	Research has mainly focused on isoleucine-proline-proline and valine-proline-proline (IPP + VPP), two lactotripeptides that can inhibit the angiotensin-converting enzyme (ACE) in vitro.	Proline	42-49	angiotensin I converting enzyme	Homo sapiens	171-174
19923186-5	2010	Finally, we find that U24 proteins from other roseoloviruses have a similar genetic organization and a conserved function that is dependent on a proline-rich motif.	Proline	145-152	small nucleolar RNA, C/D box 24	Homo sapiens	22-25
20214639-1	2010	The peptidyl prolyl isomerase (Pin1) that catalyzes the isomerization of peptide bonds involving proline and phosphorylated serine/threonine/tyrosine and alters the conformation and differential folding has been implicated in the regulation and function of phosphorylated proteins including mitotic and cell cycle proteins viz.	Proline	97-104	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	31-35
19786980-7	2010	Severe neutropenia was associated with the TP53 72 Pro/Pro, XPD 312 Asp/Asn and XRCC1 399 Arg/Arg genotypes.	Proline	51-54	tumor protein p53	Homo sapiens	43-47
20111721-7	2010	The two amino acids of YG1, proline and valine, were identified as the key residues, which were important for hTNF-alpha biological function.	Proline	28-35	tumor necrosis factor	Homo sapiens	110-120
19996102-0	2010	Proline cis/trans-isomerase Pin1 regulates peroxisome proliferator-activated receptor gamma activity through the direct binding to the activation function-1 domain.	Proline	0-7	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	28-32
19996102-0	2010	Proline cis/trans-isomerase Pin1 regulates peroxisome proliferator-activated receptor gamma activity through the direct binding to the activation function-1 domain.	Proline	0-7	peroxisome proliferator activated receptor gamma	Homo sapiens	43-91
20061803-1	2010	Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression.	Proline	48-55	cyclin dependent kinase 5	Homo sapiens	26-30
19906645-0	2010	Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl.	Proline	39-46	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	103-106
19906645-5	2010	In the light of these results, a new dual binding mechanism is proposed that provides a better description of proline-rich ligand recognition by Abl-SH3 and that has important implications for rational design.	Proline	110-117	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	145-148
19917615-3	2010	Pax6 contains two DNA binding domains (paired domain and homeodomain), a glycine-rich linker connecting these two domains and a C-terminal proline-, serine-, and threonine-rich transactivation domain.	Proline	139-146	paired box 6	Homo sapiens	0-4
19917615-5	2010	The newly isolated isoform, named Pax6(S), retains the paired domain, linker, and homeodomain of Pax6, but its C terminus is composed of a truncated classic proline, serine, and threonine domain and a unique S tail.	Proline	157-164	paired box 6	Homo sapiens	34-38
19920136-4	2010	TGF-beta binding to the cell surface receptors leads to the phosphorylation of Smad2/3 in their C terminus as well as in the proline-rich linker region.	Proline	125-132	transforming growth factor beta 1	Homo sapiens	0-8
19920136-6	2010	Pin1, a peptidyl-prolyl cis/trans isomerase, recognizes phosphorylated serine/threonine-proline motifs.	Proline	88-95	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
20082853-2	2010	To investigate the frequency of proline and arginine alleles of TP53 codon 72, the present study analyzed the DNA from blood samples of 30 Iranian women with endometrial cancer, in comparison with 32 healthy women.	Proline	32-39	tumor protein p53	Homo sapiens	64-68
19940144-4	2010	The results confirm a single, essentially fully occupied 3Hyp site (A1) at Pro(986) in A-clade chains alpha1(I), alpha1(II), and alpha2(V).	Proline	75-78	collagen type V alpha 2 chain	Homo sapiens	129-138
19214702-1	2010	The synthesis of new substituted prolines carrying at C-4 a second alpha-amino acid residue is reported.	Proline	33-41	complement C4A (Rodgers blood group)	Homo sapiens	54-57
20129060-5	2010	We further demonstrate that these Ser/Thr-Pro motifs are important for Pin1At function in promoting flowering through AGL24 and SOC1 and that the interaction between Pin1At and AGL24 mediates the AGL24 stability in the nucleus.	Proline	42-45	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Arabidopsis thaliana	71-77
20129060-5	2010	We further demonstrate that these Ser/Thr-Pro motifs are important for Pin1At function in promoting flowering through AGL24 and SOC1 and that the interaction between Pin1At and AGL24 mediates the AGL24 stability in the nucleus.	Proline	42-45	AGAMOUS-like 24	Arabidopsis thaliana	118-123
20129060-5	2010	We further demonstrate that these Ser/Thr-Pro motifs are important for Pin1At function in promoting flowering through AGL24 and SOC1 and that the interaction between Pin1At and AGL24 mediates the AGL24 stability in the nucleus.	Proline	42-45	AGAMOUS-like 20	Arabidopsis thaliana	128-132
20129060-5	2010	We further demonstrate that these Ser/Thr-Pro motifs are important for Pin1At function in promoting flowering through AGL24 and SOC1 and that the interaction between Pin1At and AGL24 mediates the AGL24 stability in the nucleus.	Proline	42-45	Auxin efflux carrier family protein	Arabidopsis thaliana	71-75
20129060-5	2010	We further demonstrate that these Ser/Thr-Pro motifs are important for Pin1At function in promoting flowering through AGL24 and SOC1 and that the interaction between Pin1At and AGL24 mediates the AGL24 stability in the nucleus.	Proline	42-45	AGAMOUS-like 24	Arabidopsis thaliana	177-182
20129060-5	2010	We further demonstrate that these Ser/Thr-Pro motifs are important for Pin1At function in promoting flowering through AGL24 and SOC1 and that the interaction between Pin1At and AGL24 mediates the AGL24 stability in the nucleus.	Proline	42-45	AGAMOUS-like 24	Arabidopsis thaliana	177-182
19880508-7	2010	Using a proline mutagenesis scanning analysis, we demonstrated that conformational changes were sufficient to cause Bax to move from the cytosol to the mitochondria.	Proline	8-15	BCL2 associated X, apoptosis regulator	Homo sapiens	116-119
19818814-3	2010	By using the fusion expression with unique acid labile linker Asp-Pro and biochemical purification, the three novel GHRH peptides, Pro-Pro-hGHRH(1-44)-Gly-Gly-Cys, Pro-hGHRH(1-44)-Gly-Gly-Cys, and (1)Pro-GHRH(2-44)-Gly-Gly-Cys, were obtained.	Proline	66-69	growth hormone releasing hormone	Rattus norvegicus	116-120
19818814-3	2010	By using the fusion expression with unique acid labile linker Asp-Pro and biochemical purification, the three novel GHRH peptides, Pro-Pro-hGHRH(1-44)-Gly-Gly-Cys, Pro-hGHRH(1-44)-Gly-Gly-Cys, and (1)Pro-GHRH(2-44)-Gly-Gly-Cys, were obtained.	Proline	66-69	growth hormone releasing hormone	Rattus norvegicus	140-144
20090852-3	2010	In GluA4, another long-tailed subunit implicated in synaptic plasticity, the PDZ motif is blocked by a single proline residue.	Proline	110-117	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	3-8
20090852-6	2010	METHODOLOGY/PRINCIPAL FINDINGS: Deletion of the carboxy-terminal proline residue of recombinant GluA4 conferred avid binding to SAP97 in cultured cells as shown by coimmunoprecipitation, whereas wild-type GluA4 did not associate with SAP97.	Proline	65-72	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	96-101
20090852-6	2010	METHODOLOGY/PRINCIPAL FINDINGS: Deletion of the carboxy-terminal proline residue of recombinant GluA4 conferred avid binding to SAP97 in cultured cells as shown by coimmunoprecipitation, whereas wild-type GluA4 did not associate with SAP97.	Proline	65-72	discs large MAGUK scaffold protein 1	Mus musculus	128-133
20090852-6	2010	METHODOLOGY/PRINCIPAL FINDINGS: Deletion of the carboxy-terminal proline residue of recombinant GluA4 conferred avid binding to SAP97 in cultured cells as shown by coimmunoprecipitation, whereas wild-type GluA4 did not associate with SAP97.	Proline	65-72	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	205-210
20090852-6	2010	METHODOLOGY/PRINCIPAL FINDINGS: Deletion of the carboxy-terminal proline residue of recombinant GluA4 conferred avid binding to SAP97 in cultured cells as shown by coimmunoprecipitation, whereas wild-type GluA4 did not associate with SAP97.	Proline	65-72	discs large MAGUK scaffold protein 1	Mus musculus	234-239
20090852-8	2010	To obtain evidence for or against the exposure of the PDZ motif by carboxyterminal processing of native GluA4 receptors, we generated an antibody reagent specific for proline-deleted GluA4 C-terminus.	Proline	167-174	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	183-188
21189685-2	2010	In many members of the family, the STAR RNA-binding domain (also named GSG, an acronym for GRP33/Sam68/ GLD-1) is flanked by regulatory regions containing proline-rich sequences, which serve as docking sites for proteins containing SH3 and WW domains and also a tyrosine-rich region at the C-terminus, which can mediateprotein-protein interactions with partners through SH2 domains.	Proline	155-162	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	97-102
19214702-4	2010	The introduction of both sulfur and selenium atoms at C-4 of the proline ring seems to enhance significantly the cis geometry at the prolyl amide bond.	Proline	65-72	complement C4A (Rodgers blood group)	Homo sapiens	54-57
21133638-5	2010	OBJECTIVE: The purpose of this study was to investigate the p53 polymorphism at codon 72 which results in encoding of either proline or arginine.	Proline	125-132	tumor protein p53	Homo sapiens	60-63
20045932-0	2010	Proline-rich domain plays a crucial role in extracellular stimuli-responsive translocation of a Cdc42 guanine nucleotide exchange factor, FGD1.	Proline	0-7	cell division cycle 42	Homo sapiens	96-101
21338227-2	2010	In the tumour suppressor Trp53 gene, a codon 72 polymorphism is frequent in the form of a single nucleotide polymorphism that leads to substitution of an arginine for a proline.	Proline	169-176	tumor protein p53	Homo sapiens	25-30
20045932-0	2010	Proline-rich domain plays a crucial role in extracellular stimuli-responsive translocation of a Cdc42 guanine nucleotide exchange factor, FGD1.	Proline	0-7	Ras protein specific guanine nucleotide releasing factor 1	Homo sapiens	102-136
20045932-7	2010	As the most striking difference, FGD3 lacks the N-terminal proline-rich domain that is conserved in FGD1, indicating that proline-rich domain may play a crucial role in signal-responsive translocation of FGD1.	Proline	59-66	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	204-208
20045932-7	2010	As the most striking difference, FGD3 lacks the N-terminal proline-rich domain that is conserved in FGD1, indicating that proline-rich domain may play a crucial role in signal-responsive translocation of FGD1.	Proline	122-129	FYVE, RhoGEF and PH domain containing 3	Homo sapiens	33-37
20045932-7	2010	As the most striking difference, FGD3 lacks the N-terminal proline-rich domain that is conserved in FGD1, indicating that proline-rich domain may play a crucial role in signal-responsive translocation of FGD1.	Proline	59-66	FYVE, RhoGEF and PH domain containing 3	Homo sapiens	33-37
20045932-0	2010	Proline-rich domain plays a crucial role in extracellular stimuli-responsive translocation of a Cdc42 guanine nucleotide exchange factor, FGD1.	Proline	0-7	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	138-142
20045932-7	2010	As the most striking difference, FGD3 lacks the N-terminal proline-rich domain that is conserved in FGD1, indicating that proline-rich domain may play a crucial role in signal-responsive translocation of FGD1.	Proline	122-129	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	204-208
20045932-8	2010	Indeed, there is a faciogenital dysplasia patient who has a missense mutation in proline-rich domain of FGD1, by which the serine residue at position 205 is substituted with isoleucine.	Proline	81-88	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	104-108
19758783-0	2010	Proline-rich polypeptide complex (PRP) regulates secretion of inflammatory mediators by its effect on NF-kappaB activity.	Proline	0-7	nuclear factor kappa B subunit 1	Homo sapiens	102-111
20476644-3	2010	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is found to be crucial in axon growth and synaptic plasticity.	Proline	38-45	cyclin-dependent kinase 5	Rattus norvegicus	0-25
20460731-6	2010	The difference caused substitution of Ala for Pro at the 277th position of the enzyme; therefore the protein encoded by AO090020000351 was overproduced and purified.	Proline	46-49	hypothetical protein	Aspergillus oryzae RIB40	120-134
20009523-3	2010	The phospho-Ser/Thr-Pro specific prolyl-isomerase Pin1 is overexpressed in many different cancers, including NSCLC, and may possibly be used as a target for cancer therapy.	Proline	20-23	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	50-54
19914066-2	2010	Recognition of p6 by Tsg101 is mediated in part by a proline-rich motif that contains the sequence "Pro-Thr-Ala-Pro" ("PTAP").	Proline	53-60	tumor susceptibility 101	Homo sapiens	21-27
19921743-3	2010	A recombinant protein, comprising the murine cortactin SH3 domain fused to GST (GST-SH3(m-cort)), was prepared and used to assess the domain-binding affinity of potential peptide-ligands reproducing the proline-rich regions of human HPK1 and Shank2 proteins.	Proline	203-210	cortactin	Mus musculus	45-54
19576684-5	2010	These results suggest that a proline in position 72 of p53 increases the risk of cervical carcinoma in Chinese population.	Proline	29-36	tumor protein p53	Homo sapiens	55-58
20476644-3	2010	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is found to be crucial in axon growth and synaptic plasticity.	Proline	38-45	cyclin-dependent kinase 5	Rattus norvegicus	27-31
20642334-0	2010	Hb Charlieu [alpha106(G13)Leu-->Pro (alpha1)]: a new phenotypically silent hemoglobin variant associated with a mild alpha-thalassemia phenotype.	Proline	32-35	amyloid beta precursor protein	Homo sapiens	5-6
20036864-1	2010	The aim of this study was to investigate interactions between cellular SH3-containing proteins and the proline-rich domain in Hepatitis B Virus (HBV) X protein (HBx) The proline-rich domain of HBx (amino acids 19-58) as well as the relevant site-directed mutagenesis (proline to alanine residues) were cloned into pGEX-5X-1 and expressed as GST-PXXP and GST-AXXA probes.	Proline	103-110	X protein	Hepatitis B virus	161-164
20036864-1	2010	The aim of this study was to investigate interactions between cellular SH3-containing proteins and the proline-rich domain in Hepatitis B Virus (HBV) X protein (HBx) The proline-rich domain of HBx (amino acids 19-58) as well as the relevant site-directed mutagenesis (proline to alanine residues) were cloned into pGEX-5X-1 and expressed as GST-PXXP and GST-AXXA probes.	Proline	103-110	X protein	Hepatitis B virus	193-196
20036864-1	2010	The aim of this study was to investigate interactions between cellular SH3-containing proteins and the proline-rich domain in Hepatitis B Virus (HBV) X protein (HBx) The proline-rich domain of HBx (amino acids 19-58) as well as the relevant site-directed mutagenesis (proline to alanine residues) were cloned into pGEX-5X-1 and expressed as GST-PXXP and GST-AXXA probes.	Proline	170-177	X protein	Hepatitis B virus	161-164
20036864-1	2010	The aim of this study was to investigate interactions between cellular SH3-containing proteins and the proline-rich domain in Hepatitis B Virus (HBV) X protein (HBx) The proline-rich domain of HBx (amino acids 19-58) as well as the relevant site-directed mutagenesis (proline to alanine residues) were cloned into pGEX-5X-1 and expressed as GST-PXXP and GST-AXXA probes.	Proline	170-177	X protein	Hepatitis B virus	193-196
20036864-1	2010	The aim of this study was to investigate interactions between cellular SH3-containing proteins and the proline-rich domain in Hepatitis B Virus (HBV) X protein (HBx) The proline-rich domain of HBx (amino acids 19-58) as well as the relevant site-directed mutagenesis (proline to alanine residues) were cloned into pGEX-5X-1 and expressed as GST-PXXP and GST-AXXA probes.	Proline	170-177	X protein	Hepatitis B virus	161-164
20036864-1	2010	The aim of this study was to investigate interactions between cellular SH3-containing proteins and the proline-rich domain in Hepatitis B Virus (HBV) X protein (HBx) The proline-rich domain of HBx (amino acids 19-58) as well as the relevant site-directed mutagenesis (proline to alanine residues) were cloned into pGEX-5X-1 and expressed as GST-PXXP and GST-AXXA probes.	Proline	170-177	X protein	Hepatitis B virus	193-196
20036864-5	2010	Our findings were consistent with similar virus-host interactions via SH3 binding for other viruses such as hepatitis C virus (HCV) and human immunodeficiency virus (HIV) Further characterization of the proline-rich binding to SH3 domains could yield important information for the design of novel therapeutic measures against downstream disease causative effects of HBx in the liver cells.	Proline	203-210	X protein	Hepatitis B virus	366-369
20353350-1	2010	We studied the structural environment surrounding the beta-N-terminal glycation site of a hemoglobin (Hb) molecule in which the proline residue at beta5(A2) was substituted by alanine in silico.	Proline	128-135	adaptor related protein complex 5 subunit beta 1	Homo sapiens	147-152
20034025-0	2010	Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma.	Proline	76-83	protein phosphatase 1, regulatory subunit 13B	Mus musculus	119-124
20130515-5	2010	RESULTS: Women homozygous for the p53 codon 72 Arg genotype were at a 5.6-fold higher risk for developing cervical intraepithelial neoplasia (CIN) 2 or 3 compared with those showing homozygosity for the Pro genotype or heterozygosity for the Pro/Arg genotype.	Proline	203-206	tumor protein p53	Homo sapiens	34-37
20414935-14	2010	Distribution of p53 gene mutations between Pro/Pro genotype and Arg/Pro plus Arg/Arg genotypes was not statistically significant.	Proline	43-46	tumor protein p53	Homo sapiens	16-19
19864419-6	2010	The phospho-Ser(112/121) region on Spry2 that binds WW domains of Nedd4 is a novel non-canonical WW domain binding region that does not contain Pro residues after phospho-Ser.	Proline	144-147	sprouty RTK signaling antagonist 2	Homo sapiens	35-40
20110589-1	2010	Pin1 [Protein Interacting with NIMA (never in mitosis A)] is a peptidyl prolyl cis-trans isomerase that isomerizes phospho-Serine/Threonine-Proline [p(S/T)-P] motifs of its target proteins.	Proline	140-147	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
19680821-2	2010	Proline-rich membrane anchor (PRiMA)-linked tetrameric globular AChE (G4 AChE) is mainly found in the vertebrate brain; however, recent studies from our laboratory have suggested its existence at neuromuscular junctions (nmjs).	Proline	0-7	proline rich membrane anchor 1	Homo sapiens	30-35
19540844-8	2010	Based on homology modeling of the KCNQ1 channel pore region, we speculate that the proline residue at position 320 limits flexibility of the outer pore and is required to maintain the functional architecture of the selectivity filter/pore helix arrangement.	Proline	83-90	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	34-39
19680821-2	2010	Proline-rich membrane anchor (PRiMA)-linked tetrameric globular AChE (G4 AChE) is mainly found in the vertebrate brain; however, recent studies from our laboratory have suggested its existence at neuromuscular junctions (nmjs).	Proline	0-7	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
19680821-2	2010	Proline-rich membrane anchor (PRiMA)-linked tetrameric globular AChE (G4 AChE) is mainly found in the vertebrate brain; however, recent studies from our laboratory have suggested its existence at neuromuscular junctions (nmjs).	Proline	0-7	acetylcholinesterase (Cartwright blood group)	Homo sapiens	73-77
19846530-7	2010	Analysis of residues within the PSI domains of human, Syrian hamster, murine, and bovine beta(3) integrins identified unique proline substitutions at residues 32 and 33 of murine and bovine PSI domains that could determine ANDV recognition.	Proline	125-132	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	89-96
20563922-6	2010	The TP53 polymorphism distribution in this population was 64 (21.1%) Arg/Arg, 55 (18.1%) Pro/Pro, and 185 (60.9%) Arg/Pro.	Proline	89-92	tumor protein p53	Homo sapiens	4-8
19855092-2	2010	Previous work has demonstrated the importance of posttranslational modifications, such as proline hydroxylation and lysine hydroxylation/glycosylation, in adiponectin oligomerization, secretion, and function.	Proline	90-97	adiponectin, C1Q and collagen domain containing	Mus musculus	155-166
20480816-3	2010	Occurrence of genotypes Ile/ Val of GSTP1 gene, Pro/Leu in GPX1 gene in the main group were lower vs. that in the reference one.	Proline	48-51	glutathione peroxidase 1	Homo sapiens	59-63
20387057-2	2010	The Delta(1)-pyrroline-5-carboxylate synthetase catalyzes the first committed step and the rate-limiting step for proline biosynthesis in both plants and mammals.	Proline	114-121	aldehyde dehydrogenase 18 family member A1	Homo sapiens	4-47
20508838-3	2010	We observed, in acute hippocampal slice preparations, that blockade of NR2A-containing NMDA receptors by the NR2A antagonist NVP-AAM077 provoked the hyperphosphorylation of a residue located in the proline-rich domain of Tau (i.e., Ser199).	Proline	198-205	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	71-75
19910490-5	2010	mAbp1, like cortactin, is a calpain 2 substrate and the preferred cleavage site occurs between the actin-binding domain and the proline-rich region, generating a C-terminal mAbp1 fragment that inhibits dorsal ruffle formation.	Proline	128-135	drebrin-like	Mus musculus	0-5
19910490-5	2010	mAbp1, like cortactin, is a calpain 2 substrate and the preferred cleavage site occurs between the actin-binding domain and the proline-rich region, generating a C-terminal mAbp1 fragment that inhibits dorsal ruffle formation.	Proline	128-135	cortactin	Homo sapiens	12-21
19910490-5	2010	mAbp1, like cortactin, is a calpain 2 substrate and the preferred cleavage site occurs between the actin-binding domain and the proline-rich region, generating a C-terminal mAbp1 fragment that inhibits dorsal ruffle formation.	Proline	128-135	drebrin-like	Mus musculus	173-178
20010840-5	2010	Key contacts involve a protruding loop in the N-terminal CD46 domain that carries two sequential proline residues (PP motif) and penetrates deeply into a hydrophobic socket in MV-H. We identify a similar PP motif in SLAM, defining a common measles virus recognition epitope in the CD46 and SLAM receptor proteins.	Proline	97-104	CD46 molecule	Homo sapiens	57-61
20010840-5	2010	Key contacts involve a protruding loop in the N-terminal CD46 domain that carries two sequential proline residues (PP motif) and penetrates deeply into a hydrophobic socket in MV-H. We identify a similar PP motif in SLAM, defining a common measles virus recognition epitope in the CD46 and SLAM receptor proteins.	Proline	97-104	CD46 molecule	Homo sapiens	281-285
20508838-3	2010	We observed, in acute hippocampal slice preparations, that blockade of NR2A-containing NMDA receptors by the NR2A antagonist NVP-AAM077 provoked the hyperphosphorylation of a residue located in the proline-rich domain of Tau (i.e., Ser199).	Proline	198-205	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	109-113
21302811-3	2010	The current study was undertaken to characterize mutations in the heterodimerization (HD) domain and proline, glutamic acid, serine, threonine-rich (PEST) domain of the Notch-1 receptor.	Proline	101-108	notch receptor 1	Homo sapiens	169-176
20160454-9	2010	In addition, both types of human tau derivatives were expressed in a "proaggregant" form (with the frontotemporal dementia with parkinsonism linked to chromosome 17 mutation DeltaK280), or in an "antiaggregant" form (with additional proline mutations to block beta-structure and aggregation).	Proline	233-240	microtubule associated protein tau	Homo sapiens	33-36
19789982-4	2010	Zera (gamma-Zein ER-accumulating domain) is the N-terminal proline-rich domain of gamma-zein that is sufficient to induce the assembly of PB formation.	Proline	59-66	prolamin 50 kDa gamma zein	Zea mays	6-16
19789982-4	2010	Zera (gamma-Zein ER-accumulating domain) is the N-terminal proline-rich domain of gamma-zein that is sufficient to induce the assembly of PB formation.	Proline	59-66	prolamin 50 kDa gamma zein	Zea mays	82-92
19764997-6	2009	Single nucleotide polymorphisms (SNPs) in TP53 (codon 72, arginine &gt; proline) and MDM2 (SNP309, T &gt; G) were genotyped using PCR-RFLP, and nuclear expression levels of p53 were examined using immunohistochemistry.	Proline	72-79	tumor protein p53	Homo sapiens	42-46
19815557-4	2009	Unlike the interaction between MIG6 and EGFR, our data suggest that these receptor tyrosine kinases require the adaptor protein Grb2 for efficient binding, which interacts with highly conserved proline-rich regions that are conserved between ACK1 and MIG6.	Proline	194-201	growth factor receptor bound protein 2	Homo sapiens	128-132
19815557-4	2009	Unlike the interaction between MIG6 and EGFR, our data suggest that these receptor tyrosine kinases require the adaptor protein Grb2 for efficient binding, which interacts with highly conserved proline-rich regions that are conserved between ACK1 and MIG6.	Proline	194-201	tyrosine kinase non receptor 2	Homo sapiens	242-246
19815557-4	2009	Unlike the interaction between MIG6 and EGFR, our data suggest that these receptor tyrosine kinases require the adaptor protein Grb2 for efficient binding, which interacts with highly conserved proline-rich regions that are conserved between ACK1 and MIG6.	Proline	194-201	ERBB receptor feedback inhibitor 1	Homo sapiens	251-255
19911840-6	2009	Moreover, these experiments also supported the known preference of Prep for shorter peptides while revealing a previously unknown cleavage site specificity of Prep when processing certain multi-proline-containing peptides, including PRPs.	Proline	194-201	prolyl endopeptidase	Mus musculus	159-163
19938836-1	2009	Dipeptides obtained from l-proline and beta(3)-l-amino acids are reported to catalyze enantioselective direct aldol reaction in aqueous medium, leading to significant anti:syn diastereomeric ratios and enantiomeric excesses.	Proline	25-34	synemin	Homo sapiens	172-175
19782660-10	2009	In summary, these data suggest that maintenance of levels of proline, other amino acids and peptides containing proline in the rat brain is regulated by prolidase isoenzymes.	Proline	61-68	peptidase D	Rattus norvegicus	153-162
19782660-10	2009	In summary, these data suggest that maintenance of levels of proline, other amino acids and peptides containing proline in the rat brain is regulated by prolidase isoenzymes.	Proline	112-119	peptidase D	Rattus norvegicus	153-162
19940238-4	2009	Here, we show that the GPVI receptor utilizes a unique intracellular proline-rich domain (PRD) to accelerate platelet activation, a requirement for efficient platelet adhesion to collagen under flow.	Proline	69-76	glycoprotein VI platelet	Homo sapiens	23-27
19875179-1	2009	Prolyl endopeptidase (PE), a protease that cleaves after proline residues in oligopeptides, is highly active in brain and degrades neuropeptides in vitro.	Proline	57-64	prolyl endopeptidase	Homo sapiens	0-20
19875179-1	2009	Prolyl endopeptidase (PE), a protease that cleaves after proline residues in oligopeptides, is highly active in brain and degrades neuropeptides in vitro.	Proline	57-64	prolyl endopeptidase	Homo sapiens	22-24
19954513-0	2009	Identification of colorectal cancer patients with tumors carrying the TP53 mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy.	Proline	100-107	tumor protein p53	Homo sapiens	70-74
19819936-7	2009	Further, we show that the proline-rich sequence and endoplasmic reticulum (ER) retention motifs in the IC domain of CD3epsilon play synergistic role in regulating TCR surface expression on DP thymocytes.	Proline	26-33	CD3 antigen, epsilon polypeptide	Mus musculus	116-126
19930468-5	2009	We show here that human CENP-V plays further roles in cell dynamics; the proline-rich region of human CENP-V associates with the SH3 domains of SFKs and potently activates SFKs, whereas another domain of CENP-V that possesses a highly conserved cysteine array confers the ability to associate with stabilized microtubules (MTs).	Proline	73-80	centromere protein V	Homo sapiens	24-30
19930468-5	2009	We show here that human CENP-V plays further roles in cell dynamics; the proline-rich region of human CENP-V associates with the SH3 domains of SFKs and potently activates SFKs, whereas another domain of CENP-V that possesses a highly conserved cysteine array confers the ability to associate with stabilized microtubules (MTs).	Proline	73-80	centromere protein V	Homo sapiens	102-108
19930468-5	2009	We show here that human CENP-V plays further roles in cell dynamics; the proline-rich region of human CENP-V associates with the SH3 domains of SFKs and potently activates SFKs, whereas another domain of CENP-V that possesses a highly conserved cysteine array confers the ability to associate with stabilized microtubules (MTs).	Proline	73-80	centromere protein V	Homo sapiens	102-108
19513708-1	2009	Homer proteins have recently been identified as novel high-affinity ligands that modulate ryanodine receptor (RyR) Ca(2+) release channels in heart and skeletal muscle, through an EVH1 domain which binds to proline-rich regions in target proteins.	Proline	207-214	ryanodine receptor 1	Homo sapiens	90-108
19513708-1	2009	Homer proteins have recently been identified as novel high-affinity ligands that modulate ryanodine receptor (RyR) Ca(2+) release channels in heart and skeletal muscle, through an EVH1 domain which binds to proline-rich regions in target proteins.	Proline	207-214	ryanodine receptor 1	Homo sapiens	110-113
19819936-7	2009	Further, we show that the proline-rich sequence and endoplasmic reticulum (ER) retention motifs in the IC domain of CD3epsilon play synergistic role in regulating TCR surface expression on DP thymocytes.	Proline	26-33	T cell receptor alpha variable 6-3	Mus musculus	163-166
19184714-0	2009	A novel allele of HWP1, isolated from a clinical strain of Candida albicans with defective hyphal growth and biofilm formation, has deletions of Gln/Pro and Ser/Thr repeats involved in cellular adhesion.	Proline	149-152	hyphal-specific cell wall protein	Candida albicans SC5314	18-22
19884661-7	2009	Insertion of 12 amino acids into the proline-rich region of LTBP4 reduced proteolytic cleavage and was associated with reduced TGF-beta signaling, decreased fibrosis, and improved muscle pathology in a mouse model of muscular dystrophy.	Proline	37-44	latent transforming growth factor beta binding protein 4	Mus musculus	60-65
20118607-5	2009	This study focuses on the isolation of variants of Put4p, which are insensitive to repression by a preferred nitrogen source (ammonia) and their subsequent effect on proline transport and stress tolerance.	Proline	166-173	proline permease PUT4	Saccharomyces cerevisiae S288C	51-56
20217194-1	2009	The regulatory functions of cMyBP-C have been attributed to the N-terminus of the protein, which is composed of tandem immunoglobulin (Ig)-like domains (C0, C1, and C2), a region rich in proline and alanine residues (the Pro-Ala rich region) that links C0 and C1, and a unique sequence referred to as the MyBP-C motif, or M-domain, that links C1 and C2.	Proline	187-194	myosin binding protein C3	Homo sapiens	29-35
20217194-1	2009	The regulatory functions of cMyBP-C have been attributed to the N-terminus of the protein, which is composed of tandem immunoglobulin (Ig)-like domains (C0, C1, and C2), a region rich in proline and alanine residues (the Pro-Ala rich region) that links C0 and C1, and a unique sequence referred to as the MyBP-C motif, or M-domain, that links C1 and C2.	Proline	221-224	myosin binding protein C3	Homo sapiens	29-35
19812155-3	2009	Here we show that physical association and subnuclear colocalization of IE1 and STAT2 depend on short acidic and serine/proline-rich low-complexity motifs in the carboxy-terminal region of the 491-amino-acid viral polypeptide.	Proline	120-127	signal transducer and activator of transcription 2	Homo sapiens	80-85
19703232-2	2009	This allele is closest related to HLA-A*310102 with one nucleotide replacement at position 221 (C&gt;T) leading to an amino acid substitution at position 50 of the mature protein from proline to leucine.	Proline	184-191	major histocompatibility complex, class I, A	Homo sapiens	34-39
20118607-0	2009	Proline transport and stress tolerance of ammonia-insensitive mutants of the PUT4-encoded proline-specific permease in yeast.	Proline	0-7	proline permease PUT4	Saccharomyces cerevisiae S288C	77-81
20118607-0	2009	Proline transport and stress tolerance of ammonia-insensitive mutants of the PUT4-encoded proline-specific permease in yeast.	Proline	90-97	proline permease PUT4	Saccharomyces cerevisiae S288C	77-81
20118607-2	2009	Proline uptake in Saccharomyces cerevisiae is largely mediated by a high affinity, specific permease, Put4p, and a low affinity general amino acid permease, Gap1p.	Proline	0-7	proline permease PUT4	Saccharomyces cerevisiae S288C	102-107
20118607-2	2009	Proline uptake in Saccharomyces cerevisiae is largely mediated by a high affinity, specific permease, Put4p, and a low affinity general amino acid permease, Gap1p.	Proline	0-7	amino acid permease GAP1	Saccharomyces cerevisiae S288C	157-162
19484491-1	2009	Proline rich polypeptide (PRP-1) produced by neurosecretory cells of the hypothalamus is one of the fragments of neurophysin-vasopressin-associated glycoprotein.	Proline	0-7	placental prolactin-related protein 1	Bos taurus	26-31
19864458-6	2009	MICAL-L1 is a largely uncharacterized member of the MICAL-family of proteins that uniquely contains two asparagine-proline-phenylalanine motifs, sequences that typically interact with EH-domains.	Proline	115-122	MICAL like 1	Homo sapiens	0-8
19940183-3	2009	The aberrant hyperphosphorylation of NF accumulations found in neurodegeneration could be attributable to either deregulation of proline-directed Ser/Thr kinase(s) activity or downregulation of protein phosphatase(s) activity.	Proline	129-136	neurofascin	Homo sapiens	37-39
19997487-4	2009	Although P3H1 is known to hydroxylate a single residue (pro-986) in type I collagen chains, it is unclear how this modification acts to facilitate collagen fibril formation.	Proline	56-59	prolyl 3-hydroxylase 1	Mus musculus	9-13
19523990-8	2009	Moreover, IMD(1-53) (10(-8) or 10(-7) mol/l) exerted a 25% and 45% respective inhibition in [(3)H]-thymidine incorporation and 16% and 36% respective inhibition in [(3)H]-proline incorporation in rat CFs incubated with AngII, and the actions of IMD(1-53) could be blocked by CGRP(8-37) and ADM(22-52).	Proline	171-178	adrenomedullin 2	Rattus norvegicus	10-13
19523990-10	2009	Otherwise, IMD(1-53) resulted in dose-dependent increases of cAMP production in CFs, and co-incubated with H89 blocked the inhibition effect of IMD(1-53) on AngII-induced [(3)H]-thymidine, [(3)H]-proline incorporation and alpha-SMA expression.	Proline	196-203	adrenomedullin 2	Rattus norvegicus	11-14
19523990-10	2009	Otherwise, IMD(1-53) resulted in dose-dependent increases of cAMP production in CFs, and co-incubated with H89 blocked the inhibition effect of IMD(1-53) on AngII-induced [(3)H]-thymidine, [(3)H]-proline incorporation and alpha-SMA expression.	Proline	196-203	adrenomedullin 2	Rattus norvegicus	144-147
19523990-10	2009	Otherwise, IMD(1-53) resulted in dose-dependent increases of cAMP production in CFs, and co-incubated with H89 blocked the inhibition effect of IMD(1-53) on AngII-induced [(3)H]-thymidine, [(3)H]-proline incorporation and alpha-SMA expression.	Proline	196-203	angiotensinogen	Rattus norvegicus	157-162
19898476-6	2009	A serine-to-proline substitution at this site confers NO(3)(-) selectivity upon the Cl(-)-specific CLC-ec1 transporter and CLC-0 channel.	Proline	12-19	Charcot-Leyden crystal galectin	Homo sapiens	99-102
19898476-6	2009	A serine-to-proline substitution at this site confers NO(3)(-) selectivity upon the Cl(-)-specific CLC-ec1 transporter and CLC-0 channel.	Proline	12-19	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	103-106
19898476-6	2009	A serine-to-proline substitution at this site confers NO(3)(-) selectivity upon the Cl(-)-specific CLC-ec1 transporter and CLC-0 channel.	Proline	12-19	Charcot-Leyden crystal galectin	Homo sapiens	123-126
19906198-1	2009	The C1q binding epicentre on IgG molecules involves residues Asp(270), Lys(322), Pro(329) and Pro(331) in the C(H)2 domain.	Proline	81-84	complement C1q A chain	Homo sapiens	4-7
19906198-1	2009	The C1q binding epicentre on IgG molecules involves residues Asp(270), Lys(322), Pro(329) and Pro(331) in the C(H)2 domain.	Proline	94-97	complement C1q A chain	Homo sapiens	4-7
19940183-6	2009	In cortical neurons, Pin1 modulates the topographic phosphorylation of the proline-directed Ser/Thr residues within the tail domain of NF proteins by inhibiting the dephosphorylation by PP2A.	Proline	75-82	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	21-25
19940183-6	2009	In cortical neurons, Pin1 modulates the topographic phosphorylation of the proline-directed Ser/Thr residues within the tail domain of NF proteins by inhibiting the dephosphorylation by PP2A.	Proline	75-82	neurofascin	Homo sapiens	135-137
19940183-6	2009	In cortical neurons, Pin1 modulates the topographic phosphorylation of the proline-directed Ser/Thr residues within the tail domain of NF proteins by inhibiting the dephosphorylation by PP2A.	Proline	75-82	protein phosphatase 2 phosphatase activator	Homo sapiens	186-190
19903888-5	2009	Structural functional analyses of DAB2IP protein indicate that both proline-rich (PR) and PERIOD-like (PER) domains, in addition to the critical role of C2 domain in ASK1 activity, are important for modulating PI3K-Akt activity.	Proline	68-75	DAB2 interacting protein	Homo sapiens	34-40
19776019-6	2009	Site-directed mutagenesis and mass spectrometry showed that PEITC covalently modified the N-terminal proline residue of MIF.	Proline	101-108	macrophage migration inhibitory factor	Homo sapiens	120-123
19638346-0	2009	Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis.	Proline	55-62	mucolipin TRP cation channel 1	Homo sapiens	28-34
19801668-6	2009	In this study, we used a combination of in vitro and in vivo phosphorylation analysis, mass spectroscopy, and functional assays to identify two sites at Ser(301) and Ser(319) within the proline/serine/threonine domain of Runx2 that are required for this regulation.	Proline	186-193	RUNX family transcription factor 2	Homo sapiens	221-226
19638346-3	2009	Our recent electrophysiological studies revealed that, although a TRPML1-mediated current can only be recorded in late endosome and lysosome (LEL) using the lysosome patch clamp technique, a proline substitution in TRPML1 (TRPML1(V432P)) results in a large whole cell current.	Proline	191-198	mucolipin TRP cation channel 1	Homo sapiens	145-146
19638346-3	2009	Our recent electrophysiological studies revealed that, although a TRPML1-mediated current can only be recorded in late endosome and lysosome (LEL) using the lysosome patch clamp technique, a proline substitution in TRPML1 (TRPML1(V432P)) results in a large whole cell current.	Proline	191-198	mucolipin TRP cation channel 1	Homo sapiens	66-72
19638346-3	2009	Our recent electrophysiological studies revealed that, although a TRPML1-mediated current can only be recorded in late endosome and lysosome (LEL) using the lysosome patch clamp technique, a proline substitution in TRPML1 (TRPML1(V432P)) results in a large whole cell current.	Proline	191-198	mucolipin TRP cation channel 1	Homo sapiens	215-221
18853251-1	2009	The p53 tumor suppressor gene has a central role in the defense against cancer, including breast cancer, and contains a polymorphic variant (Arg/Pro) at codon 72 that has been shown to have different biological properties regarding apoptosis and cell cycle arrest.	Proline	145-148	tumor protein p53	Homo sapiens	4-7
19718045-5	2009	The proline-rich region (amino acids 64-91) of p53 was most likely responsible for the observed binding because a synthetic peptide comprising amino acids 68-81 of p53 inhibited this interaction, and a p53 variant containing a proline residue at position 72 (p53(P72)) interacted with Cyp18 more effectively than the corresponding p53(R72) variant.	Proline	4-11	tumor protein p53	Homo sapiens	47-50
19718045-5	2009	The proline-rich region (amino acids 64-91) of p53 was most likely responsible for the observed binding because a synthetic peptide comprising amino acids 68-81 of p53 inhibited this interaction, and a p53 variant containing a proline residue at position 72 (p53(P72)) interacted with Cyp18 more effectively than the corresponding p53(R72) variant.	Proline	4-11	tumor protein p53	Homo sapiens	164-167
19718045-5	2009	The proline-rich region (amino acids 64-91) of p53 was most likely responsible for the observed binding because a synthetic peptide comprising amino acids 68-81 of p53 inhibited this interaction, and a p53 variant containing a proline residue at position 72 (p53(P72)) interacted with Cyp18 more effectively than the corresponding p53(R72) variant.	Proline	4-11	tumor protein p53	Homo sapiens	164-167
19718045-5	2009	The proline-rich region (amino acids 64-91) of p53 was most likely responsible for the observed binding because a synthetic peptide comprising amino acids 68-81 of p53 inhibited this interaction, and a p53 variant containing a proline residue at position 72 (p53(P72)) interacted with Cyp18 more effectively than the corresponding p53(R72) variant.	Proline	4-11	tumor protein p53	Homo sapiens	164-167
19718045-5	2009	The proline-rich region (amino acids 64-91) of p53 was most likely responsible for the observed binding because a synthetic peptide comprising amino acids 68-81 of p53 inhibited this interaction, and a p53 variant containing a proline residue at position 72 (p53(P72)) interacted with Cyp18 more effectively than the corresponding p53(R72) variant.	Proline	4-11	DEAD-box helicase 17	Homo sapiens	263-266
19718045-5	2009	The proline-rich region (amino acids 64-91) of p53 was most likely responsible for the observed binding because a synthetic peptide comprising amino acids 68-81 of p53 inhibited this interaction, and a p53 variant containing a proline residue at position 72 (p53(P72)) interacted with Cyp18 more effectively than the corresponding p53(R72) variant.	Proline	4-11	tumor protein p53	Homo sapiens	164-167
19718045-5	2009	The proline-rich region (amino acids 64-91) of p53 was most likely responsible for the observed binding because a synthetic peptide comprising amino acids 68-81 of p53 inhibited this interaction, and a p53 variant containing a proline residue at position 72 (p53(P72)) interacted with Cyp18 more effectively than the corresponding p53(R72) variant.	Proline	227-234	tumor protein p53	Homo sapiens	47-50
19665458-6	2009	In addition, the finding that deletion of or proline substitution in the most N-terminal region (residues 1-11) markedly decreased the binding to lipid further suggests that the alpha-helical structure in residues 1-11 is essential for lipid binding of SAA.	Proline	45-52	serum amyloid A1 cluster	Homo sapiens	253-256
19695763-1	2009	OBJECTIVE: Prolidase is a cytosolic exopeptidase that cleaves iminodipeptides with C-terminal proline and hydroxyproline and plays a major role in collagen turnover.	Proline	94-101	peptidase D	Homo sapiens	11-20
19576240-5	2009	AsIPS-1 shares only 18% identity in amino acid sequence with human IPS-1, but possesses the CARD, proline-rich and transmembrane domains found in mammalian IPS-1.	Proline	98-105	mitochondrial antiviral signaling protein	Homo sapiens	2-7
19718658-8	2009	Similarly, robust cellular association with SNX33 was observed only for ADAM15 isoforms containing the most carboxyterminal proline cluster lacking in isoforms i1 and i3.	Proline	124-131	sorting nexin 33	Homo sapiens	44-49
19737748-7	2009	These include hypoxia, hydroxylase inhibitors, mutation of the proline in HIF-1 that is normally modified by EGL-9, and mutation of the EGL-9 catalytic core.	Proline	63-70	Hypoxia-inducible factor 1	Caenorhabditis elegans	74-79
19737748-7	2009	These include hypoxia, hydroxylase inhibitors, mutation of the proline in HIF-1 that is normally modified by EGL-9, and mutation of the EGL-9 catalytic core.	Proline	63-70	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	109-114
19815068-5	2009	A comparison among the sequences of cathepsin D-like enzymes from some vertebrates and those found in M. domestica and in the genomes of Aedes aegypti, Drosophila melanogaster, Tribolium castaneum, and Bombyx mori showed that only flies have enzymes lacking the proline loop (as defined by the motif: DxPxPx(G/A)P), thus resembling vertebrate pepsin.	Proline	262-269	cathepsin D	Bos taurus	36-47
19718658-8	2009	Similarly, robust cellular association with SNX33 was observed only for ADAM15 isoforms containing the most carboxyterminal proline cluster lacking in isoforms i1 and i3.	Proline	124-131	ADAM metallopeptidase domain 15	Homo sapiens	72-78
19603255-3	2009	An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha hydroxylation and results in a highly active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803).	Proline	68-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	3-13
19735445-0	2009	Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling.	Proline	10-13	heme oxygenase 1	Rattus norvegicus	28-44
19735445-0	2009	Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling.	Proline	10-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-67
19735445-8	2009	These results suggest that cyclo(His-Pro), acting as a selective activator of the brain modulable Nrf2 pathway, may be a promising candidate as neuroprotective agent that act through induction of phase II genes.	Proline	37-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	98-102
19603255-3	2009	An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha hydroxylation and results in a highly active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803).	Proline	77-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	3-13
19603255-3	2009	An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha hydroxylation and results in a highly active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803).	Proline	77-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-158
19603255-3	2009	An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha hydroxylation and results in a highly active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803).	Proline	77-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-158
19780626-6	2009	Synthetic peptides tailored around the phosphorylation site of Rpl24a show that Npr1 is a Ser/Thr protein kinase with an absolute requirement for a basic residue at the P-3 position and a strong preference for basic P + 1 residues, whereas proline at P + 1 is strongly disfavored.	Proline	240-247	ribosomal 60S subunit protein L24A	Saccharomyces cerevisiae S288C	63-69
19603255-3	2009	An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha hydroxylation and results in a highly active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803).	Proline	77-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-158
19780626-6	2009	Synthetic peptides tailored around the phosphorylation site of Rpl24a show that Npr1 is a Ser/Thr protein kinase with an absolute requirement for a basic residue at the P-3 position and a strong preference for basic P + 1 residues, whereas proline at P + 1 is strongly disfavored.	Proline	240-247	serine/threonine protein kinase NPR1	Saccharomyces cerevisiae S288C	80-84
19864571-4	2009	We previously showed that V(L)12.3, an intrabody recognizing the N terminus of Htt, and Happ1, an intrabody recognizing the proline-rich domain of Htt, both reduce mHtt-induced toxicity and aggregation in cell culture and brain slice models of HD.	Proline	124-131	huntingtin	Mus musculus	147-150
19423162-2	2009	A G-C exchange at p53 codon 72 polymorphism results in a substitution of proline (Pro) for arginine (Arg) in the transactivation domain, which was shown to alter the primary structure of the p53 protein.	Proline	73-80	tumor protein p53	Homo sapiens	18-21
19423162-2	2009	A G-C exchange at p53 codon 72 polymorphism results in a substitution of proline (Pro) for arginine (Arg) in the transactivation domain, which was shown to alter the primary structure of the p53 protein.	Proline	73-80	tumor protein p53	Homo sapiens	191-194
19423162-2	2009	A G-C exchange at p53 codon 72 polymorphism results in a substitution of proline (Pro) for arginine (Arg) in the transactivation domain, which was shown to alter the primary structure of the p53 protein.	Proline	82-85	tumor protein p53	Homo sapiens	18-21
19423162-2	2009	A G-C exchange at p53 codon 72 polymorphism results in a substitution of proline (Pro) for arginine (Arg) in the transactivation domain, which was shown to alter the primary structure of the p53 protein.	Proline	82-85	tumor protein p53	Homo sapiens	191-194
19755537-4	2009	CLF is a Polycomb Group gene, and the clf-59 mutant protein contains a proline-to-serine transition in a cysteine-rich region that precedes the SET domain.	Proline	71-78	SET domain-containing protein	Arabidopsis thaliana	38-41
19214776-2	2009	It encodes 796 amino acids with 88% of identity to SRF3 of Arabidopsis thaliana and contains a signal peptide, five LRR motifs, a transmembrane domain, two proline-rich regions and a serine/threonine protein kinase domain.	Proline	156-163	STRUBBELIG-receptor family 3	Arabidopsis thaliana	51-55
19903770-2	2009	The antiangiogenic properties of HRG are mediated via its proteolytically released histidine- and proline-rich (His/Pro-rich) domain.	Proline	98-105	histidine rich glycoprotein	Homo sapiens	33-36
19706593-4	2009	Here, we present x-ray crystallography, NMR spectroscopy, and mutagenesis data that identify, for the first time, the importance of an evolutionarily conserved proline, Pro(30), in loop 1 of AHSP.	Proline	160-167	alpha hemoglobin stabilizing protein	Homo sapiens	191-195
19858347-5	2009	Distinguishing KIR2DS4 from other KIR2DS is the proline-valine motif at positions 71-72, which is shared with KIR3DL2 and was introduced by gene conversion before separation of the human and chimpanzee lineages.	Proline	48-55	killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4	Homo sapiens	15-22
19858347-5	2009	Distinguishing KIR2DS4 from other KIR2DS is the proline-valine motif at positions 71-72, which is shared with KIR3DL2 and was introduced by gene conversion before separation of the human and chimpanzee lineages.	Proline	48-55	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2	Homo sapiens	110-117
19706593-4	2009	Here, we present x-ray crystallography, NMR spectroscopy, and mutagenesis data that identify, for the first time, the importance of an evolutionarily conserved proline, Pro(30), in loop 1 of AHSP.	Proline	169-172	alpha hemoglobin stabilizing protein	Homo sapiens	191-195
19710014-3	2009	The first exon of Htt encodes 17 amino acids followed by a poly(Q) repeat of variable length and culminating with a proline-rich domain of 50 amino acids.	Proline	116-123	huntingtin	Homo sapiens	18-21
19607826-7	2009	Together, these experimental data demonstrate that Pfn1 regulates VEC migration, invasion and capillary morphogenesis through its interaction with both actin and proline-rich ligands.	Proline	162-169	profilin 1	Homo sapiens	51-55
19717557-3	2009	Itk has an N-terminal pleckstrin homology domain, a Tec Homology domain with a proline-rich region, SH3 and SH2 domains and a kinase domain, the structure each of which has been determined.	Proline	79-86	IL2 inducible T cell kinase	Homo sapiens	0-3
19717557-5	2009	Models of Itk suggest either a head to tail dimer, with the SH2 domain interacting with the SH3 domain, or a folded monomer with the SH3 domain interacting with the proline-rich region.	Proline	165-172	IL2 inducible T cell kinase	Homo sapiens	10-13
19843460-5	2009	Titin exon microarray analysis showed increased expression of a large group of exons in neonatal muscle, when compared to adult muscle transcripts, with the majority of upregulated exons coding for the elastic proline-glutamate-valine-lysine (PEVK) region of titin.	Proline	210-217	titin	Mus musculus	0-5
19843460-5	2009	Titin exon microarray analysis showed increased expression of a large group of exons in neonatal muscle, when compared to adult muscle transcripts, with the majority of upregulated exons coding for the elastic proline-glutamate-valine-lysine (PEVK) region of titin.	Proline	210-217	titin	Mus musculus	259-264
19826042-3	2009	To investigate the relationship between GPx-1 enzyme activity and genotype, we measured GPx-1 enzyme activity and protein levels in human lymphocytes as a function of the presence of two common variations: a leucine/proline polymorphism at codon 198 and a variable number of alanine-repeat codons.	Proline	216-223	glutathione peroxidase 1	Homo sapiens	40-45
19423184-7	2009	Exogenous application of proline resulted in a decrease in lipid peroxidation and an increase in SOD and CAT activities without reducing Cd contents under Cd stress, while application of betaine resulted in a decrease in lipid peroxidation and an increase in CAT activity with reducing Cd accumulation.	Proline	25-32	catalase isozyme 1	Nicotiana tabacum	105-108
19423184-7	2009	Exogenous application of proline resulted in a decrease in lipid peroxidation and an increase in SOD and CAT activities without reducing Cd contents under Cd stress, while application of betaine resulted in a decrease in lipid peroxidation and an increase in CAT activity with reducing Cd accumulation.	Proline	25-32	catalase isozyme 1	Nicotiana tabacum	259-262
19723024-4	2009	ITCs covalently modify the N-terminal proline residue of MIF and extinguish its catalytic tautomerase activity.	Proline	38-45	macrophage migration inhibitory factor	Homo sapiens	57-60
19446917-2	2009	It also induced an almost immediate and rapid increase of activity of the key enzymes Delta(1)-pyrroline-5-carboxylate synthetase and glutamate dehydrogenase of the glutamate pathway of proline biosynthesis and an up-regulation of Delta(1)-pyrroline-5-carboxylate synthetase gene expression.	Proline	186-193	Delta-1-pyrroline-5-carboxylate synthase 2	Zea mays	86-129
19446917-2	2009	It also induced an almost immediate and rapid increase of activity of the key enzymes Delta(1)-pyrroline-5-carboxylate synthetase and glutamate dehydrogenase of the glutamate pathway of proline biosynthesis and an up-regulation of Delta(1)-pyrroline-5-carboxylate synthetase gene expression.	Proline	186-193	Delta-1-pyrroline-5-carboxylate synthase 2	Zea mays	231-274
19695241-1	2009	We have found recently that membrane-bound dipeptidyl peptidase IV (DPP-IV) generated extracellularly immunoreactive endomorphin-2 from Tyr-Pro precursor in a depolarisation-sensitive manner in rat isolated L4,5 dorsal root ganglia when the enzyme was switched to synthase mode by the hydrolase inhibitor Ile-Pro-Ile.	Proline	140-143	dipeptidylpeptidase 4	Rattus norvegicus	43-66
19695241-1	2009	We have found recently that membrane-bound dipeptidyl peptidase IV (DPP-IV) generated extracellularly immunoreactive endomorphin-2 from Tyr-Pro precursor in a depolarisation-sensitive manner in rat isolated L4,5 dorsal root ganglia when the enzyme was switched to synthase mode by the hydrolase inhibitor Ile-Pro-Ile.	Proline	140-143	dipeptidylpeptidase 4	Rattus norvegicus	68-74
19807924-7	2009	In addition to known SH3 domains mediating binding to the Fas ligand proline-rich domain, we were able to identify a number of additional SH3 domains that might also associate with FasL.	Proline	69-76	Fas ligand	Homo sapiens	58-68
19728728-6	2009	When Pro was replaced with cis-3,4-methanoproline, the glutamine mimic, (4R,5S)-4-amino-5-benzyloxyhexanamide resulted in an IC(50) of 69 nM, the highest affinity Stat3 inhibitor reported to date.	Proline	5-8	signal transducer and activator of transcription 3	Homo sapiens	163-168
19807924-7	2009	In addition to known SH3 domains mediating binding to the Fas ligand proline-rich domain, we were able to identify a number of additional SH3 domains that might also associate with FasL.	Proline	69-76	Fas ligand	Homo sapiens	181-185
19656946-5	2009	Here, we report that the proline residue at the +2-position (Pro(+2)) from the signal peptide cleavage site is the determinant of NUCB1 protein export from the ER and subsequent transport to the Golgi.	Proline	25-32	nucleobindin 1	Homo sapiens	130-135
19781681-2	2009	CRTAP, P3H1, and cyclophilin B (CyPB) form an intracellular collagen-modifying complex that 3-hydroxylates proline at position 986 (P986) in the alpha1 chains of collagen type I.	Proline	107-114	cartilage associated protein	Homo sapiens	0-5
19651771-5	2009	In Xenopus oocytes, furin and PC6 function redundantly to cleave both the S1 and S2 sites of pro-BMP4, as evidenced by the results of antisense-mediated gene knockdown and the use of the furin- and PC6-selective inhibitor alpha(1)-PDX.	Proline	93-96	furin, paired basic amino acid cleaving enzyme L homeolog	Xenopus laevis	20-25
19651771-5	2009	In Xenopus oocytes, furin and PC6 function redundantly to cleave both the S1 and S2 sites of pro-BMP4, as evidenced by the results of antisense-mediated gene knockdown and the use of the furin- and PC6-selective inhibitor alpha(1)-PDX.	Proline	93-96	proprotein convertase subtilisin/kexin type 5 S homeolog	Xenopus laevis	30-33
19651771-5	2009	In Xenopus oocytes, furin and PC6 function redundantly to cleave both the S1 and S2 sites of pro-BMP4, as evidenced by the results of antisense-mediated gene knockdown and the use of the furin- and PC6-selective inhibitor alpha(1)-PDX.	Proline	93-96	bone morphogenetic protein 4 L homeolog	Xenopus laevis	97-101
19651771-5	2009	In Xenopus oocytes, furin and PC6 function redundantly to cleave both the S1 and S2 sites of pro-BMP4, as evidenced by the results of antisense-mediated gene knockdown and the use of the furin- and PC6-selective inhibitor alpha(1)-PDX.	Proline	93-96	furin, paired basic amino acid cleaving enzyme L homeolog	Xenopus laevis	187-192
19651771-5	2009	In Xenopus oocytes, furin and PC6 function redundantly to cleave both the S1 and S2 sites of pro-BMP4, as evidenced by the results of antisense-mediated gene knockdown and the use of the furin- and PC6-selective inhibitor alpha(1)-PDX.	Proline	93-96	proprotein convertase subtilisin/kexin type 5 S homeolog	Xenopus laevis	198-201
19539595-1	2009	In vitro, prolyl oligopeptidase (POP) cleaves proline-containing bioactive peptides such as substance P, gonadotropin-releasing hormone, thyrotropin-releasing hormone, arginine-vasopressin, and neurotensin.	Proline	46-53	arginine vasopressin	Rattus norvegicus	177-188
19667070-0	2009	The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides.	Proline	67-74	dipeptidyl peptidase 9	Homo sapiens	26-30
19667070-5	2009	Here we show that DPP9, a poorly characterized cytoplasmic prolyl-peptidase, is rate-limiting for destruction of proline-containing substrates both in cell extracts and in intact cells.	Proline	113-120	dipeptidyl peptidase 9	Homo sapiens	18-22
19781681-8	2009	This result and the fact that CyPB is demonstrable independent of CRTAP and P3H1, along with reported decreased 3-prolyl hydroxylation due to deficiency of CRTAP lacking the catalytic hydroxylation domain and the known function of CyPB as a cis-trans isomerase, suggest that recessive OI is caused by a dysfunctional P3H1/CRTAP/CyPB complex rather than by the lack of 3-prolyl hydroxylation of a single proline residue in the alpha1 chains of collagen type I.	Proline	403-410	cartilage associated protein	Homo sapiens	156-161
19781681-2	2009	CRTAP, P3H1, and cyclophilin B (CyPB) form an intracellular collagen-modifying complex that 3-hydroxylates proline at position 986 (P986) in the alpha1 chains of collagen type I.	Proline	107-114	prolyl 3-hydroxylase 1	Homo sapiens	7-11
19781681-2	2009	CRTAP, P3H1, and cyclophilin B (CyPB) form an intracellular collagen-modifying complex that 3-hydroxylates proline at position 986 (P986) in the alpha1 chains of collagen type I.	Proline	107-114	peptidylprolyl isomerase B	Homo sapiens	17-30
19781681-2	2009	CRTAP, P3H1, and cyclophilin B (CyPB) form an intracellular collagen-modifying complex that 3-hydroxylates proline at position 986 (P986) in the alpha1 chains of collagen type I.	Proline	107-114	peptidylprolyl isomerase B	Homo sapiens	32-36
19781681-8	2009	This result and the fact that CyPB is demonstrable independent of CRTAP and P3H1, along with reported decreased 3-prolyl hydroxylation due to deficiency of CRTAP lacking the catalytic hydroxylation domain and the known function of CyPB as a cis-trans isomerase, suggest that recessive OI is caused by a dysfunctional P3H1/CRTAP/CyPB complex rather than by the lack of 3-prolyl hydroxylation of a single proline residue in the alpha1 chains of collagen type I.	Proline	403-410	peptidylprolyl isomerase B	Homo sapiens	30-34
19781681-8	2009	This result and the fact that CyPB is demonstrable independent of CRTAP and P3H1, along with reported decreased 3-prolyl hydroxylation due to deficiency of CRTAP lacking the catalytic hydroxylation domain and the known function of CyPB as a cis-trans isomerase, suggest that recessive OI is caused by a dysfunctional P3H1/CRTAP/CyPB complex rather than by the lack of 3-prolyl hydroxylation of a single proline residue in the alpha1 chains of collagen type I.	Proline	403-410	cartilage associated protein	Homo sapiens	156-161
18930193-1	2009	OBJECTIVE: To determine whether the p53 codon 72 single nucleotide polymorphism, a change of the amino acid arginine (Arg) to proline (Pro) resulting from a single nucleotide mutation of guanine (G) to cytosine (C), has a clinically significant effect on implantation rate in fresh IVF cycles.	Proline	126-133	tumor protein p53	Homo sapiens	36-39
19789338-4	2009	Comparative analysis of substituted melanoma-differentiation antigen gp100 in complex with H-2D(b) revealed that combined introduction of glycine and proline residues at the nonanchor positions 2 and 3, respectively, resulted in an agonistic altered peptide with dramatically enhanced binding affinity, stability, and immunogenicity of this TAA.	Proline	150-157	premelanosome protein	Homo sapiens	69-74
19293837-4	2009	This single nucleotide polymorphism results in an amino acid substitution (proline to alanine) in the kinase domain of TYK2, which is predicted to influence the levels of phosphorylation and therefore activity of the protein and so is likely to have a functional role in multiple sclerosis.	Proline	75-82	tyrosine kinase 2	Homo sapiens	119-123
19423266-8	2009	An Arg>Pro switch missense mutation was found in codon 265 of the hMLH1 gene.	Proline	7-10	mutL homolog 1	Homo sapiens	66-71
18930193-1	2009	OBJECTIVE: To determine whether the p53 codon 72 single nucleotide polymorphism, a change of the amino acid arginine (Arg) to proline (Pro) resulting from a single nucleotide mutation of guanine (G) to cytosine (C), has a clinically significant effect on implantation rate in fresh IVF cycles.	Proline	135-138	tumor protein p53	Homo sapiens	36-39
19521721-5	2009	Similarly, the alleles of rs1042522 in TP53 that encode arginine (G-allele) or proline (C-allele) at codon 72, which cause increased pro-apoptotic (G-allele) or cell-cycle arrest activities (C-allele), respectively, may moderate p53"s ability to prevent DNA damage.	Proline	79-86	tumor protein p53	Homo sapiens	39-43
19521721-5	2009	Similarly, the alleles of rs1042522 in TP53 that encode arginine (G-allele) or proline (C-allele) at codon 72, which cause increased pro-apoptotic (G-allele) or cell-cycle arrest activities (C-allele), respectively, may moderate p53"s ability to prevent DNA damage.	Proline	79-86	tumor protein p53	Homo sapiens	229-232
19716516-0	2009	Structural and mechanistic roles of three consecutive Pro residues of porcine NADH-cytochrome b(5) reductase for the binding of beta-NADH.	Proline	54-57	mitochondrially encoded cytochrome b	Homo sapiens	83-95
19724906-2	2009	The deduced 920-amino acid protein encoded by the whirlin gene contains three PDZ domains and a proline-rich region that separates PDZ2 from PDZ3, which is located at the C terminus.	Proline	96-103	whirlin	Homo sapiens	50-57
19724906-4	2009	The sequence of the encoded protein shows that the short C-terminal isoform contains one PDZ domain and the proline-rich domain (whirlin isoform 2), whereas the long isoform is composed of all three PDZ domains and the proline-rich domain (whirlin isoform 1).	Proline	108-115	whirlin	Homo sapiens	129-136
19716516-1	2009	Well-conserved three consecutive Pro residues (Pro247-249) in the NADH-binding subdomain of NADH-cytochrome b(5) reductase were proposed to form a basal part of the NADH-binding site.	Proline	33-36	mitochondrially encoded cytochrome b	Homo sapiens	97-109
19707790-5	2009	The carboxy-terminal proline rich part of Inn1 binds the SH3 domains of either Cyk3 or Hof1.	Proline	21-28	Inn1p	Saccharomyces cerevisiae S288C	42-46
19546821-9	2009	The TCII allele Proline (Pro) was overrepresented into the mesothelioma cohort when compared with the controls (35 versus 19.77%).	Proline	16-23	transcobalamin 2	Homo sapiens	4-8
19546821-9	2009	The TCII allele Proline (Pro) was overrepresented into the mesothelioma cohort when compared with the controls (35 versus 19.77%).	Proline	16-19	transcobalamin 2	Homo sapiens	4-8
19656877-6	2009	Mutation of proline 346 within PP2.1 to alanine dramatically attenuated genotype 1b replicon replication in three distinct genetic backgrounds, but the corresponding proline 342 was not required for replication of the JFH-1 subgenomic replicon.	Proline	12-19	transcription elongation factor A like 1	Homo sapiens	31-36
19733656-2	2009	The proline-rich Akt substrate of 40 kDa (PRAS40) mediates the TOR signal pathway through regulation of TORC1 activity, but its functions in TORC1 proved in cultured cells are controversial.	Proline	4-11	Target of rapamycin	Drosophila melanogaster	63-66
19733656-2	2009	The proline-rich Akt substrate of 40 kDa (PRAS40) mediates the TOR signal pathway through regulation of TORC1 activity, but its functions in TORC1 proved in cultured cells are controversial.	Proline	4-11	Target of rapamycin	Drosophila melanogaster	104-109
19707790-5	2009	The carboxy-terminal proline rich part of Inn1 binds the SH3 domains of either Cyk3 or Hof1.	Proline	21-28	Cyk3p	Saccharomyces cerevisiae S288C	79-83
19707790-5	2009	The carboxy-terminal proline rich part of Inn1 binds the SH3 domains of either Cyk3 or Hof1.	Proline	21-28	formin-binding protein HOF1	Saccharomyces cerevisiae S288C	87-91
19290556-7	2009	The CMT2B2-associated missense amino acid substitution p.A335V is located in a proline-rich region with high affinity for SH3 domains of the Abelson type.	Proline	79-86	mediator complex subunit 25	Homo sapiens	4-10
19710235-9	2009	Furthermore, cold acclimation up- and down-regulated expression of P5CS1 and ProDH genes, respectively, resulting in enhanced accumulation of proline (Pro) in wild-type plants.	Proline	142-149	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	67-72
19710235-9	2009	Furthermore, cold acclimation up- and down-regulated expression of P5CS1 and ProDH genes, respectively, resulting in enhanced accumulation of proline (Pro) in wild-type plants.	Proline	142-149	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	77-82
19566594-2	2009	We show here that PERK4, a gene that encodes a member of the Arabidopsis thaliana proline-rich extensin-like receptor kinase family, plays an important role in ABA responses.	Proline	82-89	roline-rich extensin-like receptor kinase 4	Arabidopsis thaliana	18-23
19295495-8	2009	LPS/IFN-gamma downregulated the phosphorylation of multiple Akt substrates, including the proline-rich Akt substrate 40, while enhancing the phosphorylation of raptor on a 5"-AMP-activated kinase (AMPK)-regulated site.	Proline	90-97	interferon regulatory factor 6	Homo sapiens	0-3
19422058-5	2009	The molecular function and structural features of SPINK2 were also investigated by employing the recombinant active and mutant inactive SPINK2 proteins to determine its key P2-P2" (Pro(23)-Arg(24)-His(25)-Phe(26)) active site.	Proline	181-184	serine peptidase inhibitor Kazal type 2	Homo sapiens	50-56
19928529-0	2009	[Novel yeast acetyltransferase Mpr1 regulates reactive oxygen species mediated by proline metabolism].	Proline	82-89	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	31-35
19295495-8	2009	LPS/IFN-gamma downregulated the phosphorylation of multiple Akt substrates, including the proline-rich Akt substrate 40, while enhancing the phosphorylation of raptor on a 5"-AMP-activated kinase (AMPK)-regulated site.	Proline	90-97	interferon gamma	Homo sapiens	4-13
19295495-8	2009	LPS/IFN-gamma downregulated the phosphorylation of multiple Akt substrates, including the proline-rich Akt substrate 40, while enhancing the phosphorylation of raptor on a 5"-AMP-activated kinase (AMPK)-regulated site.	Proline	90-97	AKT serine/threonine kinase 1	Homo sapiens	60-63
19295495-8	2009	LPS/IFN-gamma downregulated the phosphorylation of multiple Akt substrates, including the proline-rich Akt substrate 40, while enhancing the phosphorylation of raptor on a 5"-AMP-activated kinase (AMPK)-regulated site.	Proline	90-97	AKT serine/threonine kinase 1	Homo sapiens	103-106
19679839-5	2009	In vitro phosphorylation of recombinant protein representing titin"s spring elements showed that PKCalpha targets the proline - glutamate - valine - lysine (PEVK) spring element.	Proline	118-125	titin	Homo sapiens	61-66
20021811-3	2009	The WT1 gene consists of 10 exons, with exons 1 to 6 encoding an N-terminal proline- and glutamine-rich transactivational domain, and exons 7 to 10 encoding a C-terminal zinc-finger domain involved in DNA binding.	Proline	76-83	WT1 transcription factor	Homo sapiens	4-7
19679839-5	2009	In vitro phosphorylation of recombinant protein representing titin"s spring elements showed that PKCalpha targets the proline - glutamate - valine - lysine (PEVK) spring element.	Proline	118-125	protein kinase C alpha	Homo sapiens	97-105
19635803-1	2009	The two-step oxidation of proline in all eukaryotes is performed at the inner mitochondrial membrane by the consecutive action of proline dehydrogenase (ProDH) that produces Delta(1)-pyrroline-5-carboxylate (P5C) and P5C dehydrogenase (P5CDH) that oxidizes P5C to glutamate.	Proline	26-33	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	130-151
19635803-1	2009	The two-step oxidation of proline in all eukaryotes is performed at the inner mitochondrial membrane by the consecutive action of proline dehydrogenase (ProDH) that produces Delta(1)-pyrroline-5-carboxylate (P5C) and P5C dehydrogenase (P5CDH) that oxidizes P5C to glutamate.	Proline	26-33	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	153-158
19635803-1	2009	The two-step oxidation of proline in all eukaryotes is performed at the inner mitochondrial membrane by the consecutive action of proline dehydrogenase (ProDH) that produces Delta(1)-pyrroline-5-carboxylate (P5C) and P5C dehydrogenase (P5CDH) that oxidizes P5C to glutamate.	Proline	26-33	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	217-234
19635803-1	2009	The two-step oxidation of proline in all eukaryotes is performed at the inner mitochondrial membrane by the consecutive action of proline dehydrogenase (ProDH) that produces Delta(1)-pyrroline-5-carboxylate (P5C) and P5C dehydrogenase (P5CDH) that oxidizes P5C to glutamate.	Proline	26-33	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	236-241
19539694-0	2009	A new variant of proline-rich membrane anchor (PRiMA) of acetylcholinesterase in chicken: expression in different muscle fiber types.	Proline	17-24	proline rich membrane anchor 1	Homo sapiens	47-52
19539694-0	2009	A new variant of proline-rich membrane anchor (PRiMA) of acetylcholinesterase in chicken: expression in different muscle fiber types.	Proline	17-24	acetylcholinesterase (Cartwright blood group)	Gallus gallus	57-77
19539694-1	2009	Proline-rich membrane anchor (PRiMA) is a molecule to organize acetylcholinesterase (AChE) into tetrameric globular form (G(4)) that anchors onto the plasma membrane in brain and muscle.	Proline	0-7	proline rich membrane anchor 1	Homo sapiens	30-35
19539694-1	2009	Proline-rich membrane anchor (PRiMA) is a molecule to organize acetylcholinesterase (AChE) into tetrameric globular form (G(4)) that anchors onto the plasma membrane in brain and muscle.	Proline	0-7	acetylcholinesterase (Cartwright blood group)	Gallus gallus	63-83
19539694-1	2009	Proline-rich membrane anchor (PRiMA) is a molecule to organize acetylcholinesterase (AChE) into tetrameric globular form (G(4)) that anchors onto the plasma membrane in brain and muscle.	Proline	0-7	acetylcholinesterase (Cartwright blood group)	Gallus gallus	85-89
19444904-6	2009	Pro-carriers of ERCC6 Arg1230Pro showed a decreased risk for laryngeal cancer (OR = 0.53, 95% CI 0.34-0.85), strongest in heavy smokers and high alcohol consumers.	Proline	0-3	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	16-21
19635999-6	2009	NOTCH1 heterodimerization domain mutations were associated with FBXW7 mutations (P = .02), and NOTCH1 proline, glutamic acid, serine, threonine (PEST) rich domain and FBXW7 mutations were mutually exclusive.	Proline	102-109	notch receptor 1	Homo sapiens	95-101
19592703-6	2009	Significantly, the tandem WW domains of FBP21 are connected by a highly flexible region, enabling their simultaneous interaction with two proline-rich motifs of SIPP1.	Proline	138-145	WW domain binding protein 4	Homo sapiens	40-45
19592703-6	2009	Significantly, the tandem WW domains of FBP21 are connected by a highly flexible region, enabling their simultaneous interaction with two proline-rich motifs of SIPP1.	Proline	138-145	WW domain binding protein 11	Homo sapiens	161-166
19586919-4	2009	CD2 and CD244 both contribute positively to the immune response as mutation of proline-rich motifs or tyrosine motifs in the tails of CD2 and CD244, respectively, result in a decrease in antigen-specific interleukin-2 production.	Proline	79-86	CD2 antigen	Mus musculus	0-3
19586919-4	2009	CD2 and CD244 both contribute positively to the immune response as mutation of proline-rich motifs or tyrosine motifs in the tails of CD2 and CD244, respectively, result in a decrease in antigen-specific interleukin-2 production.	Proline	79-86	CD244 molecule A	Mus musculus	8-13
19586919-4	2009	CD2 and CD244 both contribute positively to the immune response as mutation of proline-rich motifs or tyrosine motifs in the tails of CD2 and CD244, respectively, result in a decrease in antigen-specific interleukin-2 production.	Proline	79-86	CD2 antigen	Mus musculus	8-11
19586919-4	2009	CD2 and CD244 both contribute positively to the immune response as mutation of proline-rich motifs or tyrosine motifs in the tails of CD2 and CD244, respectively, result in a decrease in antigen-specific interleukin-2 production.	Proline	79-86	CD244 molecule A	Mus musculus	142-147
19586919-4	2009	CD2 and CD244 both contribute positively to the immune response as mutation of proline-rich motifs or tyrosine motifs in the tails of CD2 and CD244, respectively, result in a decrease in antigen-specific interleukin-2 production.	Proline	79-86	interleukin 2	Mus musculus	204-217
19645436-5	2009	Our analysis showed that the conserved linker amino acids glutamine 222 and proline 229 play important roles in Smad functions such as homo- and hetero-oligomerization, nuclear accumulation in response to TGFbeta stimulation, and DNA binding.	Proline	76-83	transforming growth factor beta 1	Homo sapiens	205-212
19574222-2	2009	The transcriptional activator Put3p allows yeast cells to utilize proline as a nitrogen source through expression of the PUT1 and PUT2 genes.	Proline	66-73	Put3p	Saccharomyces cerevisiae S288C	30-35
19748341-3	2009	The structure of Htt17Q-EX1 consists of an amino-terminal alpha helix, poly17Q region, and polyproline helix formed by the proline-rich region.	Proline	95-102	FERM domain containing 6	Homo sapiens	24-27
19574222-3	2009	Put3p activates high level transcription of these genes by binding proline directly.	Proline	67-74	Put3p	Saccharomyces cerevisiae S288C	0-5
19574222-2	2009	The transcriptional activator Put3p allows yeast cells to utilize proline as a nitrogen source through expression of the PUT1 and PUT2 genes.	Proline	66-73	proline dehydrogenase	Saccharomyces cerevisiae S288C	121-125
19574222-6	2009	The proline-independent activation of the PUT genes requires both Put3p and the positively acting GATA factors, Gln3p and Gat1p.	Proline	4-11	Put3p	Saccharomyces cerevisiae S288C	66-71
19574222-2	2009	The transcriptional activator Put3p allows yeast cells to utilize proline as a nitrogen source through expression of the PUT1 and PUT2 genes.	Proline	66-73	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	130-134
19574222-6	2009	The proline-independent activation of the PUT genes requires both Put3p and the positively acting GATA factors, Gln3p and Gat1p.	Proline	4-11	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	112-117
19574222-6	2009	The proline-independent activation of the PUT genes requires both Put3p and the positively acting GATA factors, Gln3p and Gat1p.	Proline	4-11	Gat1p	Saccharomyces cerevisiae S288C	122-127
19574222-8	2009	Here, we find that the mutation of Put3p at amino acid Tyr-788 modulates the proline-independent activation of PUT1 through Gat1p.	Proline	77-84	Put3p	Saccharomyces cerevisiae S288C	35-40
19574222-8	2009	Here, we find that the mutation of Put3p at amino acid Tyr-788 modulates the proline-independent activation of PUT1 through Gat1p.	Proline	77-84	proline dehydrogenase	Saccharomyces cerevisiae S288C	111-115
19574222-8	2009	Here, we find that the mutation of Put3p at amino acid Tyr-788 modulates the proline-independent activation of PUT1 through Gat1p.	Proline	77-84	Gat1p	Saccharomyces cerevisiae S288C	124-129
19487247-11	2009	The data confirm a pivotal role for an N-terminal domain proline in the glucuronidation of the tertiary amines LTG and TFP by UGT1A subfamily proteins, whereas glucuronidation reactions involving proton abstraction generally, although not invariably, require a histidine at the equivalent position in both UGT1A and UGT2B enzymes.	Proline	57-64	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	126-131
19487247-11	2009	The data confirm a pivotal role for an N-terminal domain proline in the glucuronidation of the tertiary amines LTG and TFP by UGT1A subfamily proteins, whereas glucuronidation reactions involving proton abstraction generally, although not invariably, require a histidine at the equivalent position in both UGT1A and UGT2B enzymes.	Proline	57-64	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	306-311
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Proline	53-60	N-acetyltransferase 2	Homo sapiens	108-112
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Proline	62-65	N-acetyltransferase 2	Homo sapiens	108-112
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Proline	62-65	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Proline	62-65	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Proline	62-65	N-acetyltransferase 2	Homo sapiens	119-123
19890497-1	2009	Pin1 specifically catalyzes the cis/trans isomerization of phospho-Ser/Thr-Pro bonds and plays an important role in many cellular events through the effects of conformational change on the function of its biological substrates, including cell division cycle 25 C (Cdc25C), c-Jun and p53.	Proline	75-78	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
19890497-1	2009	Pin1 specifically catalyzes the cis/trans isomerization of phospho-Ser/Thr-Pro bonds and plays an important role in many cellular events through the effects of conformational change on the function of its biological substrates, including cell division cycle 25 C (Cdc25C), c-Jun and p53.	Proline	75-78	cell division cycle 25C	Homo sapiens	264-270
19890497-1	2009	Pin1 specifically catalyzes the cis/trans isomerization of phospho-Ser/Thr-Pro bonds and plays an important role in many cellular events through the effects of conformational change on the function of its biological substrates, including cell division cycle 25 C (Cdc25C), c-Jun and p53.	Proline	75-78	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	273-278
19890497-1	2009	Pin1 specifically catalyzes the cis/trans isomerization of phospho-Ser/Thr-Pro bonds and plays an important role in many cellular events through the effects of conformational change on the function of its biological substrates, including cell division cycle 25 C (Cdc25C), c-Jun and p53.	Proline	75-78	tumor protein p53	Homo sapiens	283-286
19683529-4	2009	The deduced sequence of MCL-1ES encodes a protein of 197 amino acids, and the PEST (proline, glutamic acid, serine, and threonine) motifs present in MCL-1L are absent.	Proline	84-91	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	24-31
19734662-0	2009	Proline as a stress protectant in the yeast Saccharomyces cerevisiae: effects of trehalose and PRO1 gene expression on stress tolerance.	Proline	0-7	glutamate 5-kinase	Saccharomyces cerevisiae S288C	95-99
19454314-5	2009	Replacement of NSP3"s serine/proline-rich domain with that of AND-34/BCAR3 instills the ability to induce p130Cas phosphorylation.	Proline	29-36	SH2 domain containing 3C	Homo sapiens	15-19
19454314-5	2009	Replacement of NSP3"s serine/proline-rich domain with that of AND-34/BCAR3 instills the ability to induce p130Cas phosphorylation.	Proline	29-36	BCAR3 adaptor protein, NSP family member	Homo sapiens	69-74
19454314-5	2009	Replacement of NSP3"s serine/proline-rich domain with that of AND-34/BCAR3 instills the ability to induce p130Cas phosphorylation.	Proline	29-36	BCAR1 scaffold protein, Cas family member	Homo sapiens	106-113
19178525-9	2009	RESULTS: Plasma resistin appeared to be higher in subjects with the Pro/Pro genotype of PPARgamma than those with Pro/Ala and Ala/Ala genotypes (mean +/- SE, 11.6 +/- 0.2 vs. 10.4 +/- 0.5 microg/l).	Proline	68-71	resistin	Homo sapiens	16-24
19178525-9	2009	RESULTS: Plasma resistin appeared to be higher in subjects with the Pro/Pro genotype of PPARgamma than those with Pro/Ala and Ala/Ala genotypes (mean +/- SE, 11.6 +/- 0.2 vs. 10.4 +/- 0.5 microg/l).	Proline	68-71	peroxisome proliferator activated receptor gamma	Homo sapiens	88-97
19487247-0	2009	Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10.	Proline	45-52	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	102-133
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Proline	95-102	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	45-51
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Proline	95-102	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	53-59
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Proline	95-102	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	61-67
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Proline	95-102	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	73-79
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Proline	95-102	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	121-128
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Proline	68-71	N-acetyltransferase 2	Homo sapiens	108-112
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Proline	68-71	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Proline	68-71	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Proline	68-71	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Proline	68-71	N-acetyltransferase 2	Homo sapiens	108-112
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Proline	68-71	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Proline	68-71	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Proline	68-71	N-acetyltransferase 2	Homo sapiens	119-123
19415410-3	2009	The genetic polymorphism of GPx1 encoding gene (GPx1) associated with the proline (Pro) to leucine (Leu) change at codon 198 is supposed to be functional.	Proline	74-81	glutathione peroxidase 1	Homo sapiens	28-32
19415410-3	2009	The genetic polymorphism of GPx1 encoding gene (GPx1) associated with the proline (Pro) to leucine (Leu) change at codon 198 is supposed to be functional.	Proline	74-81	glutathione peroxidase 1	Homo sapiens	48-52
19415410-3	2009	The genetic polymorphism of GPx1 encoding gene (GPx1) associated with the proline (Pro) to leucine (Leu) change at codon 198 is supposed to be functional.	Proline	83-86	glutathione peroxidase 1	Homo sapiens	28-32
19415410-3	2009	The genetic polymorphism of GPx1 encoding gene (GPx1) associated with the proline (Pro) to leucine (Leu) change at codon 198 is supposed to be functional.	Proline	83-86	glutathione peroxidase 1	Homo sapiens	48-52
19433476-0	2009	An apoA-I mimetic peptide containing a proline residue has greater in vivo HDL binding and anti-inflammatory ability than the 4F peptide.	Proline	39-46	apolipoprotein A-I	Mus musculus	3-9
19687473-1	2009	Prolyl oligopeptidase (POP) is a serine endopeptidase that hydrolyses proline-containing peptides shorter than 30 amino acids.	Proline	70-77	prolyl endopeptidase	Homo sapiens	0-21
19687473-1	2009	Prolyl oligopeptidase (POP) is a serine endopeptidase that hydrolyses proline-containing peptides shorter than 30 amino acids.	Proline	70-77	prolyl endopeptidase	Homo sapiens	23-26
19767579-5	2009	Mmp-20 cleaves amelogenin sequences after Pro(162), Ser(148), His(62), Ala(63), and Trp(45).	Proline	42-45	matrix metallopeptidase 20	Sus scrofa	0-6
19767579-5	2009	Mmp-20 cleaves amelogenin sequences after Pro(162), Ser(148), His(62), Ala(63), and Trp(45).	Proline	42-45	amelogenin	Sus scrofa	15-25
19767579-7	2009	Mmp-20 cleaves LRAP after Pro(45) and Pro(40), producing the two LRAP products previously identified in tooth extracts.	Proline	26-29	matrix metallopeptidase 20	Sus scrofa	0-6
19767579-7	2009	Mmp-20 cleaves LRAP after Pro(45) and Pro(40), producing the two LRAP products previously identified in tooth extracts.	Proline	26-29	amelogenin	Sus scrofa	15-19
19767579-7	2009	Mmp-20 cleaves LRAP after Pro(45) and Pro(40), producing the two LRAP products previously identified in tooth extracts.	Proline	38-41	matrix metallopeptidase 20	Sus scrofa	0-6
19767579-7	2009	Mmp-20 cleaves LRAP after Pro(45) and Pro(40), producing the two LRAP products previously identified in tooth extracts.	Proline	38-41	amelogenin	Sus scrofa	15-19
19433476-1	2009	Modifying apolipoprotein (apo) A-I mimetic peptides to include a proline-punctuated alpha-helical repeat increases their anti-inflammatory properties as well as allows better mimicry of full-length apoA-I function.	Proline	65-72	apolipoprotein A-I	Mus musculus	198-204
19564421-3	2009	We identified a cluster of phosphoserine-proline sites in Phox2a by mass spectrometry.	Proline	41-48	paired like homeobox 2A	Homo sapiens	58-64
19822105-5	2009	This effect may be partly due to the possibility that leghemoglobin may mimic the function of cytoglobin by shuttling oxygen to prolyl-4-hydroxylase, the enzyme responsible for oxidizing proline residues in procollagen bundles.	Proline	187-194	cytoglobin	Homo sapiens	94-104
19383516-6	2009	While most cathepsin cysteine proteinases are unable to digest collagen, mammalian cathepsin K, adult F. hepatica FhCL2 and the plant zingipain can also cleave collagen and substrates with Pro in P2 position, but only FhCL3 and zingipain hydrolyze these substrates with the highest efficiency.	Proline	189-192	cathepsin K	Homo sapiens	83-94
19627555-0	2009	The proline biosynthetic genes P5CS1 and P5CS2 play overlapping roles in Arabidopsis flower transition but not in embryo development.	Proline	4-11	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	31-36
21475903-4	2009	Polymorphisms of TP53 include codon 72 containing either arginine (CGC) or proline (CCC).	Proline	75-82	tumor protein p53	Homo sapiens	17-21
19627555-0	2009	The proline biosynthetic genes P5CS1 and P5CS2 play overlapping roles in Arabidopsis flower transition but not in embryo development.	Proline	4-11	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	41-46
19627555-1	2009	Overexpression of the proline biosynthetic gene P5CS1 results in early flowering in Arabidopsis.	Proline	22-29	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	48-53
19627555-7	2009	Accordingly, exogenous proline accelerated organ growth and meristem formation, and stimulated expression of the cell cycle-related protein CYCB1;1.	Proline	23-30	CYCLIN B1;1	Arabidopsis thaliana	140-145
19531642-1	2009	Cyclin-dependent kinase-5 (Cdk5), a proline-directed serine/threonine kinase, may alter pain-related neuronal plasticity by regulating extracellular signal-related kinase-1/2 (ERK1/2) activation.	Proline	36-43	cyclin-dependent kinase 5	Rattus norvegicus	0-25
19696351-4	2009	Pi21 encodes a proline-rich protein that includes a putative heavy metal-binding domain and putative protein-protein interaction motifs.	Proline	15-22	protein PYRICULARIA ORYZAE RESISTANCE 21	Oryza sativa Japonica Group	0-4
19654292-3	2009	Proline oxidase (POX), catalyzing the first step in proline catabolism, is induced by p53 and can regulate cell survival as well as mediate programmed cell death.	Proline	52-59	proline dehydrogenase 1	Homo sapiens	0-15
19654292-3	2009	Proline oxidase (POX), catalyzing the first step in proline catabolism, is induced by p53 and can regulate cell survival as well as mediate programmed cell death.	Proline	52-59	proline dehydrogenase 1	Homo sapiens	17-20
19654292-3	2009	Proline oxidase (POX), catalyzing the first step in proline catabolism, is induced by p53 and can regulate cell survival as well as mediate programmed cell death.	Proline	52-59	tumor protein p53	Homo sapiens	86-89
19542232-8	2009	The strict requirement for copper, oxygen, and CCS in disulfide bond oxidation appears exclusive to yeast SOD1, and we find that a unique proline at position 144 in yeast SOD1 is responsible for this disulfide effect.	Proline	138-145	copper chaperone for superoxide dismutase	Homo sapiens	47-50
19542232-8	2009	The strict requirement for copper, oxygen, and CCS in disulfide bond oxidation appears exclusive to yeast SOD1, and we find that a unique proline at position 144 in yeast SOD1 is responsible for this disulfide effect.	Proline	138-145	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	171-175
19546225-5	2009	It takes place downstream of the proline-rich domain of MAVS, within an STP motif, characteristic of the binding of PLK1 to its targets, where the central Thr234 residue is phosphorylated.	Proline	33-40	mitochondrial antiviral signaling protein	Homo sapiens	56-60
19546225-5	2009	It takes place downstream of the proline-rich domain of MAVS, within an STP motif, characteristic of the binding of PLK1 to its targets, where the central Thr234 residue is phosphorylated.	Proline	33-40	polo like kinase 1	Homo sapiens	116-120
19572596-0	2009	A novel iron-catalyzed decarboxylative Csp3-Csp2 coupling of proline derivatives and naphthol.	Proline	61-68	regulator of calcineurin 2	Homo sapiens	44-48
19589778-6	2009	Kinetic analyses revealed differential contributions toward the functional activity of Hgt1p by these residues and identified Asn-124 in transmembrane domain 1 (TMD1), Gln-222 in TMD4, Gln-526 in TMD9, and Glu-544, Arg-554, and Lys-562 in the intracellular loop region 537-568 containing the highly conserved proline-rich motif to be essential for the transport activity of the protein.	Proline	309-316	oligopeptide transporter OPT1	Saccharomyces cerevisiae S288C	87-92
19442657-2	2009	Here we show that the interaction between hMSH5 and c-Abl confers ionizing radiation (IR)-induced apoptotic response by promoting c-Abl activation and p73 accumulation, and these effects are greatly enhanced in cells expressing hMSH5(P29S) (i.e. the hMSH5 variant possessing a proline to serine change within the N-terminal (Px)(5) dipeptide repeat).	Proline	277-284	mutS homolog 5	Homo sapiens	42-47
19442657-2	2009	Here we show that the interaction between hMSH5 and c-Abl confers ionizing radiation (IR)-induced apoptotic response by promoting c-Abl activation and p73 accumulation, and these effects are greatly enhanced in cells expressing hMSH5(P29S) (i.e. the hMSH5 variant possessing a proline to serine change within the N-terminal (Px)(5) dipeptide repeat).	Proline	277-284	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	52-57
19442657-2	2009	Here we show that the interaction between hMSH5 and c-Abl confers ionizing radiation (IR)-induced apoptotic response by promoting c-Abl activation and p73 accumulation, and these effects are greatly enhanced in cells expressing hMSH5(P29S) (i.e. the hMSH5 variant possessing a proline to serine change within the N-terminal (Px)(5) dipeptide repeat).	Proline	277-284	mutS homolog 5	Homo sapiens	228-233
19442657-2	2009	Here we show that the interaction between hMSH5 and c-Abl confers ionizing radiation (IR)-induced apoptotic response by promoting c-Abl activation and p73 accumulation, and these effects are greatly enhanced in cells expressing hMSH5(P29S) (i.e. the hMSH5 variant possessing a proline to serine change within the N-terminal (Px)(5) dipeptide repeat).	Proline	277-284	mutS homolog 5	Homo sapiens	228-233
19531642-1	2009	Cyclin-dependent kinase-5 (Cdk5), a proline-directed serine/threonine kinase, may alter pain-related neuronal plasticity by regulating extracellular signal-related kinase-1/2 (ERK1/2) activation.	Proline	36-43	cyclin-dependent kinase 5	Rattus norvegicus	27-31
19531642-1	2009	Cyclin-dependent kinase-5 (Cdk5), a proline-directed serine/threonine kinase, may alter pain-related neuronal plasticity by regulating extracellular signal-related kinase-1/2 (ERK1/2) activation.	Proline	36-43	mitogen activated protein kinase 3	Rattus norvegicus	176-182
19594829-0	2009	Male-specific expression of Sox9 during gonad development of crocodile and mouse is mediated by alternative splicing of its proline-glutamine-alanine rich domain.	Proline	124-131	SRY (sex determining region Y)-box 9	Mus musculus	28-32
19515556-1	2009	Hypoxia-inducible factor (HIF)-1alpha undergoes degradation under normoxia, which involves its proline hydroxylation and subsequent binding of proline-hydroxylated HIF-1alpha to the von Hippel-Lindau protein-Elongin B-Elongin C (VBC) complex.	Proline	95-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-37
19515556-1	2009	Hypoxia-inducible factor (HIF)-1alpha undergoes degradation under normoxia, which involves its proline hydroxylation and subsequent binding of proline-hydroxylated HIF-1alpha to the von Hippel-Lindau protein-Elongin B-Elongin C (VBC) complex.	Proline	143-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-37
19515556-1	2009	Hypoxia-inducible factor (HIF)-1alpha undergoes degradation under normoxia, which involves its proline hydroxylation and subsequent binding of proline-hydroxylated HIF-1alpha to the von Hippel-Lindau protein-Elongin B-Elongin C (VBC) complex.	Proline	143-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	164-174
19515556-1	2009	Hypoxia-inducible factor (HIF)-1alpha undergoes degradation under normoxia, which involves its proline hydroxylation and subsequent binding of proline-hydroxylated HIF-1alpha to the von Hippel-Lindau protein-Elongin B-Elongin C (VBC) complex.	Proline	143-150	elongin B	Homo sapiens	208-217
19515556-1	2009	Hypoxia-inducible factor (HIF)-1alpha undergoes degradation under normoxia, which involves its proline hydroxylation and subsequent binding of proline-hydroxylated HIF-1alpha to the von Hippel-Lindau protein-Elongin B-Elongin C (VBC) complex.	Proline	143-150	elongin C	Homo sapiens	218-227
19515556-2	2009	In this study, we designed and synthesized a series of peptides containing 556-575 residues of HIF-1alpha with modifications at the Pro-564 residue to inhibit the interaction between proline-hydroxylated HIF-1alpha and VBC.	Proline	132-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-105
19515556-2	2009	In this study, we designed and synthesized a series of peptides containing 556-575 residues of HIF-1alpha with modifications at the Pro-564 residue to inhibit the interaction between proline-hydroxylated HIF-1alpha and VBC.	Proline	132-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	204-214
19515556-2	2009	In this study, we designed and synthesized a series of peptides containing 556-575 residues of HIF-1alpha with modifications at the Pro-564 residue to inhibit the interaction between proline-hydroxylated HIF-1alpha and VBC.	Proline	183-190	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-105
19515556-2	2009	In this study, we designed and synthesized a series of peptides containing 556-575 residues of HIF-1alpha with modifications at the Pro-564 residue to inhibit the interaction between proline-hydroxylated HIF-1alpha and VBC.	Proline	183-190	hypoxia inducible factor 1 subunit alpha	Homo sapiens	204-214
19515556-5	2009	Considering that proline hydroxylation of HIF-1alpha is routinely targeted for modulating the HIF pathway, our approach of using inhibitors against the interactions between HIF-1alpha and VBC would provide an alternative way of upregulating HIF-1 activity.	Proline	17-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-52
19515556-5	2009	Considering that proline hydroxylation of HIF-1alpha is routinely targeted for modulating the HIF pathway, our approach of using inhibitors against the interactions between HIF-1alpha and VBC would provide an alternative way of upregulating HIF-1 activity.	Proline	17-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	173-183
19515556-5	2009	Considering that proline hydroxylation of HIF-1alpha is routinely targeted for modulating the HIF pathway, our approach of using inhibitors against the interactions between HIF-1alpha and VBC would provide an alternative way of upregulating HIF-1 activity.	Proline	17-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-47
19691140-4	2009	The amino acid sequence of Ci-CT was shown to display high similarity to those of vertebrate CTs and to share CT consensus motifs, including the N-terminal circular region and C-terminal amidated proline.	Proline	196-203	calcitonin	Ciona intestinalis	27-32
19691140-4	2009	The amino acid sequence of Ci-CT was shown to display high similarity to those of vertebrate CTs and to share CT consensus motifs, including the N-terminal circular region and C-terminal amidated proline.	Proline	196-203	calcitonin	Ciona intestinalis	30-32
19423552-14	2009	Multiple variants, including an Ala to Pro variant in codon 90 (rs2086310) of human ADAMTS16, were associated with human resting systolic BP (SBP).	Proline	39-42	ADAM metallopeptidase with thrombospondin type 1 motif 16	Homo sapiens	84-92
19606067-2	2009	These alterations of the NGF metabolic pathway likely resulted in the increased pro-NGF levels.	Proline	80-83	nerve growth factor	Rattus norvegicus	25-28
19524300-3	2009	Substitution of proline-14 in the CATH-2 hinge region by leucine, but not by glycine, strongly reduced antibacterial and hemolytic activity.	Proline	16-23	cathelicidin-2	Gallus gallus	34-40
19402132-3	2009	We reported that BAG3 overexpression in MDA435 human breast cancer cells results in a significant decrease in migration and adhesion to matrix molecules that is reversed upon deletion of the BAG3 proline-rich domain (dPXXP).	Proline	196-203	BAG cochaperone 3	Homo sapiens	17-21
19402132-3	2009	We reported that BAG3 overexpression in MDA435 human breast cancer cells results in a significant decrease in migration and adhesion to matrix molecules that is reversed upon deletion of the BAG3 proline-rich domain (dPXXP).	Proline	196-203	BAG cochaperone 3	Homo sapiens	191-195
19487459-4	2009	Here we show that T172 phosphorylation of CDK4 is conditioned by its unique proline 173 residue.	Proline	76-83	cyclin dependent kinase 4	Homo sapiens	42-46
19487459-6	2009	Mutations of proline 173 did not adversely affect CDK4 activation by CDK7, but in cells they abolished CDK4 T172 phosphorylation and activity.	Proline	13-20	cyclin dependent kinase 4	Homo sapiens	103-107
19487459-7	2009	Conversely, substituting a proline for the corresponding residue of CDK6 enforced its complete, apparently cyclin-independent T177 phosphorylation and dramatically increased its activity.	Proline	27-34	cyclin dependent kinase 6	Homo sapiens	68-72
19487459-7	2009	Conversely, substituting a proline for the corresponding residue of CDK6 enforced its complete, apparently cyclin-independent T177 phosphorylation and dramatically increased its activity.	Proline	27-34	proliferating cell nuclear antigen	Homo sapiens	107-113
19470755-5	2009	Abl binds a proline-rich motif in Cdo via its SH3 domain, and these regions of Abl and Cdo are required for their promyogenic effects.	Proline	12-19	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-3
19470755-5	2009	Abl binds a proline-rich motif in Cdo via its SH3 domain, and these regions of Abl and Cdo are required for their promyogenic effects.	Proline	12-19	cell adhesion associated, oncogene regulated	Homo sapiens	34-37
19470755-5	2009	Abl binds a proline-rich motif in Cdo via its SH3 domain, and these regions of Abl and Cdo are required for their promyogenic effects.	Proline	12-19	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	79-82
19470755-5	2009	Abl binds a proline-rich motif in Cdo via its SH3 domain, and these regions of Abl and Cdo are required for their promyogenic effects.	Proline	12-19	cell adhesion associated, oncogene regulated	Homo sapiens	87-90
19597489-2	2009	Because of its activity to switch the conformation of peptidyl-proline bonds in polypeptide chains, Pin1 operates as a binary switch, often in fate-determining pathways.	Proline	63-70	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	100-104
19439498-11	2009	Finally, Pin1 binding was mapped to two threonine-proline motifs (Thr(8) and Thr(11)) that are not present in any of the other human cytosolic sulfotransferases.	Proline	50-57	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	9-13
19478091-7	2009	The proline mutant (but not the alanine mutant) inhibited co-expressed wild type connexin37.	Proline	4-11	gap junction protein alpha 4	Homo sapiens	81-91
19464300-5	2009	These results are further corroborated by pull-down assays and isothermal titration calorimetry showing that both intact SH3 domains are required for efficient binding to the entire proline-rich domain of Sos1.	Proline	182-189	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	205-209
19464300-7	2009	Furthermore, it leads to an alteration in the recognition of binding motifs for the interaction with Sos1: While the insertion abrogates the interaction with the majority of peptides derived from the proline-rich domains of Sos1 and dynamin that are recognized by the short splice isoform, it enables binding to a different set of peptides including a sequence comprising the splice insertion in the long isoform of Sos1 (Sos1_2).	Proline	200-207	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	101-105
19464300-7	2009	Furthermore, it leads to an alteration in the recognition of binding motifs for the interaction with Sos1: While the insertion abrogates the interaction with the majority of peptides derived from the proline-rich domains of Sos1 and dynamin that are recognized by the short splice isoform, it enables binding to a different set of peptides including a sequence comprising the splice insertion in the long isoform of Sos1 (Sos1_2).	Proline	200-207	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	224-228
19464300-7	2009	Furthermore, it leads to an alteration in the recognition of binding motifs for the interaction with Sos1: While the insertion abrogates the interaction with the majority of peptides derived from the proline-rich domains of Sos1 and dynamin that are recognized by the short splice isoform, it enables binding to a different set of peptides including a sequence comprising the splice insertion in the long isoform of Sos1 (Sos1_2).	Proline	200-207	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	224-228
19464300-7	2009	Furthermore, it leads to an alteration in the recognition of binding motifs for the interaction with Sos1: While the insertion abrogates the interaction with the majority of peptides derived from the proline-rich domains of Sos1 and dynamin that are recognized by the short splice isoform, it enables binding to a different set of peptides including a sequence comprising the splice insertion in the long isoform of Sos1 (Sos1_2).	Proline	200-207	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	224-228
19464300-8	2009	In the absence of the basic insertion, Tks5 was found to bind a range of Sos1 and dynamin peptides including conventional proline-rich motifs and atypical recognition sequences.	Proline	122-129	SH3 and PX domains 2A	Homo sapiens	39-43
19509291-5	2009	Grb2 was identified as its binding partner, and the proline-rich motifs of GAREM are recognized by the N- and C-terminal SH3 domains of Grb2.	Proline	52-59	growth factor receptor bound protein 2	Homo sapiens	0-4
19509291-5	2009	Grb2 was identified as its binding partner, and the proline-rich motifs of GAREM are recognized by the N- and C-terminal SH3 domains of Grb2.	Proline	52-59	GRB2 associated regulator of MAPK1 subtype 1	Homo sapiens	75-80
19509291-5	2009	Grb2 was identified as its binding partner, and the proline-rich motifs of GAREM are recognized by the N- and C-terminal SH3 domains of Grb2.	Proline	52-59	growth factor receptor bound protein 2	Homo sapiens	136-140
19473966-4	2009	Unlike HO-1, which lacks cysteine residues, HO-2 contains three Cys-Pro signatures, known as heme regulatory motifs (HRMs), which are known to control processes related to iron and oxidative metabolism in organisms from bacteria to humans.	Proline	68-71	heme oxygenase 2	Homo sapiens	44-48
19643038-0	2009	Effects of epitope sequence tandem repeat and proline incorporation on polyclonal antibody production against cytochrome 1A2 and 3A4.	Proline	46-53	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	110-124
19643038-1	2009	We describe a method for producing polyclonal antibodies against peptide antigen cytochrome P450 1A2 and 3A4 using a tandem repeat of the epitope region and incorporation of proline residue between the repeated sequences.	Proline	174-181	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	81-100
19527069-6	2009	Altering the C-terminal-most Pro or Phe residues in the SSB-Ct strongly impairs SSB-Ct binding to ExoI, confirming a major role for the hydrophobic SSB-Ct residues in binding ExoI.	Proline	29-32	single-stranded DNA-binding protein	Escherichia coli	56-62
19527069-6	2009	Altering the C-terminal-most Pro or Phe residues in the SSB-Ct strongly impairs SSB-Ct binding to ExoI, confirming a major role for the hydrophobic SSB-Ct residues in binding ExoI.	Proline	29-32	single-stranded DNA-binding protein	Escherichia coli	80-86
19527069-6	2009	Altering the C-terminal-most Pro or Phe residues in the SSB-Ct strongly impairs SSB-Ct binding to ExoI, confirming a major role for the hydrophobic SSB-Ct residues in binding ExoI.	Proline	29-32	single-stranded DNA-binding protein	Escherichia coli	80-86
19542373-1	2009	The CD3 epsilon subunit of the TCR complex contains two defined signaling domains, a proline-rich sequence and an ITAM.	Proline	85-92	CD3 antigen, epsilon polypeptide	Mus musculus	4-7
19605405-7	2009	Proteomic analysis identified proline, glutamic acid, and leucine rich protein 1 (PELP1) as a DACH1-binding protein.	Proline	30-37	proline, glutamate and leucine rich protein 1	Homo sapiens	82-87
19605405-7	2009	Proteomic analysis identified proline, glutamic acid, and leucine rich protein 1 (PELP1) as a DACH1-binding protein.	Proline	30-37	dachshund family transcription factor 1	Homo sapiens	94-99
19576563-11	2009	PYCR1 plays a critical role in proline biosynthesis.	Proline	31-38	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-5
19448667-6	2009	We found a proline-rich region unique to BRG1 was required for binding to the histone acetyl transferase protein, CBP, as well as to p53.	Proline	11-18	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	41-45
19448667-6	2009	We found a proline-rich region unique to BRG1 was required for binding to the histone acetyl transferase protein, CBP, as well as to p53.	Proline	11-18	CREB binding protein	Homo sapiens	114-117
19448667-6	2009	We found a proline-rich region unique to BRG1 was required for binding to the histone acetyl transferase protein, CBP, as well as to p53.	Proline	11-18	tumor protein p53	Homo sapiens	133-136
19448667-7	2009	Ectopic expression of a proline-rich region deletion mutant BRG1 that is defective for CBP binding inhibited p53 destabilization.	Proline	24-31	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	60-64
19448667-7	2009	Ectopic expression of a proline-rich region deletion mutant BRG1 that is defective for CBP binding inhibited p53 destabilization.	Proline	24-31	CREB binding protein	Homo sapiens	87-90
19448667-7	2009	Ectopic expression of a proline-rich region deletion mutant BRG1 that is defective for CBP binding inhibited p53 destabilization.	Proline	24-31	tumor protein p53	Homo sapiens	109-112
19541618-3	2009	Here, we identify a hydrophobic motif within the proline-rich sequence (PRS) of MEK1 and MEK2 that is required for constitutive binding to KSR1 and find that MEK binding and residues in the KSR1 CA1 region enable KSR1 to form a ternary complex with B-Raf and MEK following growth factor treatment that enhances MEK activation.	Proline	49-56	mitogen-activated protein kinase kinase 1	Homo sapiens	80-84
19541618-3	2009	Here, we identify a hydrophobic motif within the proline-rich sequence (PRS) of MEK1 and MEK2 that is required for constitutive binding to KSR1 and find that MEK binding and residues in the KSR1 CA1 region enable KSR1 to form a ternary complex with B-Raf and MEK following growth factor treatment that enhances MEK activation.	Proline	49-56	mitogen-activated protein kinase kinase 2	Homo sapiens	89-93
19541618-3	2009	Here, we identify a hydrophobic motif within the proline-rich sequence (PRS) of MEK1 and MEK2 that is required for constitutive binding to KSR1 and find that MEK binding and residues in the KSR1 CA1 region enable KSR1 to form a ternary complex with B-Raf and MEK following growth factor treatment that enhances MEK activation.	Proline	49-56	kinase suppressor of ras 1	Homo sapiens	139-143
19541618-3	2009	Here, we identify a hydrophobic motif within the proline-rich sequence (PRS) of MEK1 and MEK2 that is required for constitutive binding to KSR1 and find that MEK binding and residues in the KSR1 CA1 region enable KSR1 to form a ternary complex with B-Raf and MEK following growth factor treatment that enhances MEK activation.	Proline	49-56	mitogen-activated protein kinase kinase 7	Homo sapiens	80-83
19541618-3	2009	Here, we identify a hydrophobic motif within the proline-rich sequence (PRS) of MEK1 and MEK2 that is required for constitutive binding to KSR1 and find that MEK binding and residues in the KSR1 CA1 region enable KSR1 to form a ternary complex with B-Raf and MEK following growth factor treatment that enhances MEK activation.	Proline	49-56	kinase suppressor of ras 1	Homo sapiens	190-194
19541618-3	2009	Here, we identify a hydrophobic motif within the proline-rich sequence (PRS) of MEK1 and MEK2 that is required for constitutive binding to KSR1 and find that MEK binding and residues in the KSR1 CA1 region enable KSR1 to form a ternary complex with B-Raf and MEK following growth factor treatment that enhances MEK activation.	Proline	49-56	kinase suppressor of ras 1	Homo sapiens	190-194
19541618-3	2009	Here, we identify a hydrophobic motif within the proline-rich sequence (PRS) of MEK1 and MEK2 that is required for constitutive binding to KSR1 and find that MEK binding and residues in the KSR1 CA1 region enable KSR1 to form a ternary complex with B-Raf and MEK following growth factor treatment that enhances MEK activation.	Proline	49-56	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	249-254
19541618-3	2009	Here, we identify a hydrophobic motif within the proline-rich sequence (PRS) of MEK1 and MEK2 that is required for constitutive binding to KSR1 and find that MEK binding and residues in the KSR1 CA1 region enable KSR1 to form a ternary complex with B-Raf and MEK following growth factor treatment that enhances MEK activation.	Proline	49-56	mitogen-activated protein kinase kinase 7	Homo sapiens	89-92
19541618-3	2009	Here, we identify a hydrophobic motif within the proline-rich sequence (PRS) of MEK1 and MEK2 that is required for constitutive binding to KSR1 and find that MEK binding and residues in the KSR1 CA1 region enable KSR1 to form a ternary complex with B-Raf and MEK following growth factor treatment that enhances MEK activation.	Proline	49-56	mitogen-activated protein kinase kinase 7	Homo sapiens	89-92
19480463-5	2009	We have determined the structure of Def-A in SDS micelle and found that it is folded into two distinct helices separated by a proline kink.	Proline	126-133	UTP25 small subunit processome component	Homo sapiens	36-39
19584355-4	2009	We further show that the interaction of pVHL with beta(2)AR is dependent on proline hydroxylation (proline-382 and -395) and that the dioxygenase EGLN3 interacts directly with the beta(2)AR to serve as an endogenous beta(2)AR prolyl hydroxylase.	Proline	76-83	von Hippel-Lindau tumor suppressor	Homo sapiens	40-44
19584355-4	2009	We further show that the interaction of pVHL with beta(2)AR is dependent on proline hydroxylation (proline-382 and -395) and that the dioxygenase EGLN3 interacts directly with the beta(2)AR to serve as an endogenous beta(2)AR prolyl hydroxylase.	Proline	76-83	adrenoceptor beta 2	Homo sapiens	50-59
19584355-4	2009	We further show that the interaction of pVHL with beta(2)AR is dependent on proline hydroxylation (proline-382 and -395) and that the dioxygenase EGLN3 interacts directly with the beta(2)AR to serve as an endogenous beta(2)AR prolyl hydroxylase.	Proline	99-106	von Hippel-Lindau tumor suppressor	Homo sapiens	40-44
19584355-4	2009	We further show that the interaction of pVHL with beta(2)AR is dependent on proline hydroxylation (proline-382 and -395) and that the dioxygenase EGLN3 interacts directly with the beta(2)AR to serve as an endogenous beta(2)AR prolyl hydroxylase.	Proline	99-106	adrenoceptor beta 2	Homo sapiens	50-59
19576563-12	2009	Pathogenicity of the genetic variant in PYCR1 is likely, given that a similar clinical phenotype has been documented for mutation carriers of another proline biosynthetic enzyme, pyrroline-5-carboxylate synthase.	Proline	150-157	pyrroline-5-carboxylate reductase 1	Homo sapiens	40-45
19409937-4	2009	WASP and NLP are colocalized on vesicles and interactions between two molecules via the SH3 domain of NLP/SLP and the proline-rich repeats of WASP are required for vesicle formation from Golgi.	Proline	118-125	WASP actin nucleation promoting factor	Homo sapiens	0-4
19409937-4	2009	WASP and NLP are colocalized on vesicles and interactions between two molecules via the SH3 domain of NLP/SLP and the proline-rich repeats of WASP are required for vesicle formation from Golgi.	Proline	118-125	WASP actin nucleation promoting factor	Homo sapiens	142-146
19052714-4	2009	RESULTS: The Arg/Pro and Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to the combination chemotherapy when compared to the Arg/Arg genotype (35.7 vs. 66.7%, P-value 0.019) in a logistic regression analysis.	Proline	17-20	tumor protein p53	Homo sapiens	46-50
19584562-0	2009	Mutational analysis of uncharged polar residues and proline in the distal one-third (Thr130-Pro142) of the highly conserved region of mouse Slc10a2.	Proline	52-59	solute carrier family 10, member 2	Mus musculus	140-147
19584562-2	2009	Alignment of deduced amino acid sequences of SLC10 family members and homologous genes in various species revealed a highly conserved region that corresponds to Gly(104)-Pro(142) of SLC10A2.	Proline	170-173	solute carrier family 10, member 2	Mus musculus	182-189
19502294-4	2009	We report the first disease-causing mutation in the proline-rich domain of dynamin 2.	Proline	52-59	dynamin 2	Homo sapiens	75-84
19052714-4	2009	RESULTS: The Arg/Pro and Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to the combination chemotherapy when compared to the Arg/Arg genotype (35.7 vs. 66.7%, P-value 0.019) in a logistic regression analysis.	Proline	25-28	tumor protein p53	Homo sapiens	46-50
19052714-4	2009	RESULTS: The Arg/Pro and Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to the combination chemotherapy when compared to the Arg/Arg genotype (35.7 vs. 66.7%, P-value 0.019) in a logistic regression analysis.	Proline	25-28	tumor protein p53	Homo sapiens	46-50
19052714-5	2009	A multivariate survival analysis also showed that the time to progression for the patients with the Arg/Pro and Pro/Pro genotypes of TP53 codon 72 was worse than for the patients with the Arg/Arg genotype (Hazard ratio = 3.056, P-value = 0.047), whereas the overall survival was not significantly different.	Proline	104-107	tumor protein p53	Homo sapiens	133-137
19459151-4	2009	Characterization of ste2 yeast overexpressing Ste2p variants indicated that residues Ile 24 and Ile 29 as well as Pro 15 are critical in mediating mating efficiency.	Proline	114-117	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	46-51
19523119-4	2009	By bioinformatics predictions, CD spectroscopy, wide-line and 1H-NMR spectroscopy, limited proteolysis and gel filtration chromatography, we provided evidence that the entire proline-rich region of CASK-interactive protein1 is intrinsically disordered.	Proline	175-182	calcium/calmodulin dependent serine protein kinase	Homo sapiens	198-202
19523119-5	2009	We also showed that the proline-rich region is biochemically functional, as it interacts with the adaptor protein Abl-interactor-2.	Proline	24-31	abl interactor 2	Homo sapiens	114-130
19415679-2	2009	Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by proline oxidase (POX), a mitochondrial inner membrane enzyme, can generate ATP.	Proline	0-7	proline dehydrogenase 1	Homo sapiens	219-234
19398000-6	2009	A single amino acid change at the I785 cleavage site to proline resulted in partial MMP-1 resistance, but cuts were found in novel sites in the original cleavage region.	Proline	56-63	matrix metallopeptidase 1	Homo sapiens	84-89
19415679-2	2009	Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by proline oxidase (POX), a mitochondrial inner membrane enzyme, can generate ATP.	Proline	0-7	proline dehydrogenase 1	Homo sapiens	236-239
19415679-2	2009	Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by proline oxidase (POX), a mitochondrial inner membrane enzyme, can generate ATP.	Proline	172-179	proline dehydrogenase 1	Homo sapiens	219-234
19415679-2	2009	Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by proline oxidase (POX), a mitochondrial inner membrane enzyme, can generate ATP.	Proline	172-179	proline dehydrogenase 1	Homo sapiens	236-239
19415679-2	2009	Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by proline oxidase (POX), a mitochondrial inner membrane enzyme, can generate ATP.	Proline	172-179	proline dehydrogenase 1	Homo sapiens	219-234
19415679-2	2009	Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by proline oxidase (POX), a mitochondrial inner membrane enzyme, can generate ATP.	Proline	172-179	proline dehydrogenase 1	Homo sapiens	236-239
19457112-2	2009	Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase involved not only in neuronal development, but also in synaptic function and plasticity.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
19457112-2	2009	Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase involved not only in neuronal development, but also in synaptic function and plasticity.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
19498081-1	2009	The prolyl-4-hydroxylase proteins regulate the hypoxia-inducible transcription factors (HIFs) by hydroxylation of proline residues targeting HIF-1alpha for proteasomal degradation.	Proline	114-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-151
19398000-7	2009	However, the replacement of five Y-position residues by proline in this region, regardless of I785 variation, conferred complete resistance to MMP-1, MMP-8, MMP-13, trypsin, and elastase.	Proline	56-63	matrix metallopeptidase 1	Homo sapiens	143-148
19398000-7	2009	However, the replacement of five Y-position residues by proline in this region, regardless of I785 variation, conferred complete resistance to MMP-1, MMP-8, MMP-13, trypsin, and elastase.	Proline	56-63	matrix metallopeptidase 8	Homo sapiens	150-155
19398000-7	2009	However, the replacement of five Y-position residues by proline in this region, regardless of I785 variation, conferred complete resistance to MMP-1, MMP-8, MMP-13, trypsin, and elastase.	Proline	56-63	matrix metallopeptidase 13	Homo sapiens	157-186
19401189-8	2009	Mutations in PTK6 at R22, W44, N65, and Y66 residues in the SH3 domain increased catalytic activity compared with wild-type protein, implying that specific interactions between hydrophobic residues in the proline-rich linker region and hydrophobic residues in the SH3 domain are mainly responsible for down-regulating the catalytic activity of PTK6.	Proline	205-212	protein tyrosine kinase 6	Homo sapiens	13-17
19446882-1	2009	A novel heterozygous mutation in the clusterin gene, nucleotide position A1298C (glutamine&gt;proline Q433P), was detected in exon 7 of a child with recurrent hemolytic uremic syndrome (HUS).	Proline	94-101	clusterin	Homo sapiens	37-46
19398586-4	2009	Furthermore, we demonstrate that signaling initiated by the C-terminal proline motif is directly responsible for tyrosine phosphorylation of phosphoinosotide-dependent kinase 1, protein kinase C theta, and glycogen synthase kinase 3beta, as well as contributing to threonine phosphorylation of PKB.	Proline	71-78	protein kinase C, theta	Mus musculus	178-236
19398586-4	2009	Furthermore, we demonstrate that signaling initiated by the C-terminal proline motif is directly responsible for tyrosine phosphorylation of phosphoinosotide-dependent kinase 1, protein kinase C theta, and glycogen synthase kinase 3beta, as well as contributing to threonine phosphorylation of PKB.	Proline	71-78	thymoma viral proto-oncogene 1	Mus musculus	294-297
19470478-3	2009	The p53 allele encoding proline at codon 72 (P72) was found to be significantly enriched over the allele encoding arginine (R72) among in vitro fertilization (IVF) patients.	Proline	24-31	tumor protein p53	Homo sapiens	4-7
19419969-2	2009	Prolyl 3-hydroxylase 1 modifies a single proline residue in the alpha chains of type I, II, and III collagens to (3S)-hydroxyproline.	Proline	41-48	prolyl 3-hydroxylase 1	Gallus gallus	0-22
19449895-0	2009	Iterative approach to enantiopure syn/anti-1,3-polyols via proline-catalyzed sequential alpha-aminoxylation and Horner-Wadsworth-Emmons olefination of aldehydes.	Proline	59-66	synemin	Homo sapiens	34-37
19473029-0	2009	Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.	Proline	30-37	melanocortin 4 receptor	Homo sapiens	128-151
19473029-0	2009	Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.	Proline	42-49	melanocortin 4 receptor	Homo sapiens	128-151
19380579-9	2009	We then mutated residues that reside in the hydrophobic pocket of CypA where proline-containing peptide substrates and cyclosporine A bind and that are vital for the enzymatic or the hydrophobic pocket binding activity of CypA.	Proline	77-84	peptidylprolyl isomerase A	Homo sapiens	66-70
19380579-9	2009	We then mutated residues that reside in the hydrophobic pocket of CypA where proline-containing peptide substrates and cyclosporine A bind and that are vital for the enzymatic or the hydrophobic pocket binding activity of CypA.	Proline	77-84	peptidylprolyl isomerase A	Homo sapiens	222-226
19402713-4	2009	Recombinant FAP cleavage of peptide libraries of short amino acid sequences surrounding the scissile bond, -Pro(12)-Asn(13)-, indicated that P2 Gly and P1 Pro are required, just as we found for APCE.	Proline	108-111	fibroblast activation protein alpha	Homo sapiens	12-15
19470478-3	2009	The p53 allele encoding proline at codon 72 (P72) was found to be significantly enriched over the allele encoding arginine (R72) among in vitro fertilization (IVF) patients.	Proline	24-31	DEAD-box helicase 17	Homo sapiens	45-48
19523902-3	2009	Structural modeling based on small angle X-ray scattering (SAXS) data reveals an elongated crescent-shaped conformation for dimeric ALIX lacking the proline-rich domain (ALIX(BRO1-V)).	Proline	149-156	programmed cell death 6 interacting protein	Homo sapiens	132-136
19494129-5	2009	EFA6A encompasses proline-rich regions, a Sec7 domain (mediating GEF activity on ARF6), a PH domain, and a C-terminal region with coiled-coil motifs.	Proline	18-25	pleckstrin and Sec7 domain containing	Homo sapiens	0-5
19462037-4	2009	MD calculations indicate a population of conformers which adopt folded beta turn structures for all the L-peptides; on the other hand, a D-stereochemistry at the Pro residue induces a natural folding towards a beta hairpin conformation driven by the formation of a second hydrogen bond, regardless of the stereochemistry of the stereogenic peptide bond surrogate.	Proline	162-165	amyloid beta precursor protein	Homo sapiens	208-214
19508102-4	2009	In this work we focused on the role of proline in the Pro-Val-Pro (PVP) motif of the inner S6 helix in the Kv1.2 channel.	Proline	39-46	potassium voltage-gated channel subfamily A member 2	Homo sapiens	107-112
19405512-2	2009	The key steps include diastereoselective proline-catalyzed syn aldol transformation and a reductive amination/cyclization.	Proline	41-48	synemin	Homo sapiens	59-62
19486677-5	2009	The profound differences in the free energy landscapes of the rIAPP and hIAPP dimers explains the lack of fibril formation in hIAPP upon substitution of the C-terminal residues by proline.	Proline	180-187	islet amyloid polypeptide	Homo sapiens	72-77
19529798-1	2009	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that has been implicated in learning, synaptic plasticity, neurotransmission, and numerous neurological disorders.	Proline	38-45	cyclin-dependent kinase 5	Mus musculus	0-25
21544223-7	2009	Finally, simulations suggest that cis/trans isomerization of a conserved proline residue in Kinesin-2 accounts for the differing predictions of molecular dynamics and the WLC model, and may contribute to motor regulation in vivo.	Proline	73-80	kinesin family member 2A	Homo sapiens	92-101
19529798-1	2009	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that has been implicated in learning, synaptic plasticity, neurotransmission, and numerous neurological disorders.	Proline	38-45	cyclin-dependent kinase 5	Mus musculus	27-31
19499153-2	2009	A cDNA encoding a putative classical AGP named GhH6L was isolated from cotton fiber cDNA libraries, and the deduced protein contains 17 copies of repetitive motif of X-Y-proline-proline-proline (where X is serine or alanine and Y is threonine or serine).	Proline	170-177	classical arabinogalactan protein 9-like	Gossypium hirsutum	47-52
19499153-2	2009	A cDNA encoding a putative classical AGP named GhH6L was isolated from cotton fiber cDNA libraries, and the deduced protein contains 17 copies of repetitive motif of X-Y-proline-proline-proline (where X is serine or alanine and Y is threonine or serine).	Proline	178-185	classical arabinogalactan protein 9-like	Gossypium hirsutum	47-52
19170243-1	2009	The budding yeast Saccharomyces cerevisiae Sigma1278b has the MPR1 gene, which confers resistance to the proline analogue azetidine-2-carboxylate (AZC).	Proline	105-112	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	62-66
19435668-0	2009	Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2.	Proline	83-90	RoBo-1	Rattus norvegicus	40-44
18373731-3	2009	Here, we addressed this issue and found that cyclo(His-Pro) triggered nuclear accumulation of NF-E2-related factor-2 (Nrf2), a transcription factor that up-regulates antioxidant-/electrophile-responsive element (ARE-EpRE)-related genes, in PC12 cells.	Proline	55-58	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-116
19533842-3	2009	Of those without collagen mutations, a number of them will have mutations involving the enzyme complex responsible for posttranslational hydroxylation of the position 3 proline residue of COL1A1.	Proline	169-176	collagen type I alpha 1 chain	Homo sapiens	188-194
19490106-0	2009	Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions--contribution and expression from motor neurons.	Proline	27-34	proline rich membrane anchor 1	Rattus norvegicus	57-62
19490106-1	2009	The expression and localization of the proline-rich membrane anchor (PRiMA), an anchoring protein of tetrameric globular form acetylcholinesterase (G(4) AChE), were studied at vertebrate neuromuscular junctions.	Proline	39-46	proline rich membrane anchor 1	Rattus norvegicus	69-74
19490106-1	2009	The expression and localization of the proline-rich membrane anchor (PRiMA), an anchoring protein of tetrameric globular form acetylcholinesterase (G(4) AChE), were studied at vertebrate neuromuscular junctions.	Proline	39-46	acetylcholinesterase	Rattus norvegicus	153-157
18373731-3	2009	Here, we addressed this issue and found that cyclo(His-Pro) triggered nuclear accumulation of NF-E2-related factor-2 (Nrf2), a transcription factor that up-regulates antioxidant-/electrophile-responsive element (ARE-EpRE)-related genes, in PC12 cells.	Proline	55-58	NFE2 like bZIP transcription factor 2	Rattus norvegicus	118-122
19428754-1	2009	The point mutations at residue 726 Pro in the nonstructural gene 2 (nsP2-726P) could make Sindbis virus (SINV) replicons lacking the structural protein-coding region less cytopathic and capable of persisting in some vertebrate cell lines.	Proline	35-38	reticulon 2	Homo sapiens	68-72
19067160-1	2009	Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase that is activated mostly by association with its activators, p35 and p39.	Proline	38-45	cyclin-dependent kinase 5	Danio rerio	0-25
19067160-1	2009	Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase that is activated mostly by association with its activators, p35 and p39.	Proline	38-45	cyclin-dependent kinase 5	Danio rerio	27-31
19067160-1	2009	Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase that is activated mostly by association with its activators, p35 and p39.	Proline	38-45	cyclin-dependent kinase 5, regulatory subunit 1b (p35)	Danio rerio	140-143
19067160-1	2009	Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase that is activated mostly by association with its activators, p35 and p39.	Proline	38-45	cyclin-dependent kinase 5, regulatory subunit 2a (p39)	Danio rerio	148-151
19342071-6	2009	This attenuation of activity was caused by a single serine-to-proline substitution in baboon TRIM5alpha V2.	Proline	62-69	tripartite motif-containing protein 5	Macaca fascicularis	93-103
19268648-1	2009	Dipetidyl peptidase 9 (DPP9) is a prolyl dipeptidase preferentially cleaving the peptide bond after the penultimate proline residue.	Proline	116-123	dipeptidyl peptidase 9	Homo sapiens	0-21
19268648-1	2009	Dipetidyl peptidase 9 (DPP9) is a prolyl dipeptidase preferentially cleaving the peptide bond after the penultimate proline residue.	Proline	116-123	dipeptidyl peptidase 9	Homo sapiens	23-27
19188489-3	2009	Based on specific DPP activities and inhibition profiles, the proline-selective DPP activity in the bovine and rat testis could predominantly be attributed to DPP8/9 and not to DPP4.	Proline	62-69	dipeptidylpeptidase 8	Rattus norvegicus	159-165
19188489-3	2009	Based on specific DPP activities and inhibition profiles, the proline-selective DPP activity in the bovine and rat testis could predominantly be attributed to DPP8/9 and not to DPP4.	Proline	62-69	dipeptidylpeptidase 4	Rattus norvegicus	177-181
19176688-3	2009	For this reason, we assessed the association of four TGF-beta-1 polymorphic variants (C-509T, Leu(10)--&gt;Pro, Arg(25)--&gt;Pro, Thr(263)--&gt;Ile) with albuminuria in uncomplicated essential hypertensive men, using (circulating active + acid-activatable latent) TGF-beta-1 levels as an indirect index of their in vivo biological activity.	Proline	107-110	transforming growth factor beta 1	Homo sapiens	53-63
19297321-6	2009	NMR heteronuclear exchange spectroscopy yielded direct evidence that many proline residues in NS5A-D2 form a valid substrate for the enzymatic peptidyl-prolyl cis/trans isomerase (PPIase) activity of CypA and CypB.	Proline	74-81	peptidylprolyl isomerase like 1	Homo sapiens	143-178
19297321-6	2009	NMR heteronuclear exchange spectroscopy yielded direct evidence that many proline residues in NS5A-D2 form a valid substrate for the enzymatic peptidyl-prolyl cis/trans isomerase (PPIase) activity of CypA and CypB.	Proline	74-81	peptidylprolyl isomerase like 1	Homo sapiens	180-186
19297321-6	2009	NMR heteronuclear exchange spectroscopy yielded direct evidence that many proline residues in NS5A-D2 form a valid substrate for the enzymatic peptidyl-prolyl cis/trans isomerase (PPIase) activity of CypA and CypB.	Proline	74-81	peptidylprolyl isomerase A	Homo sapiens	200-204
19297321-6	2009	NMR heteronuclear exchange spectroscopy yielded direct evidence that many proline residues in NS5A-D2 form a valid substrate for the enzymatic peptidyl-prolyl cis/trans isomerase (PPIase) activity of CypA and CypB.	Proline	74-81	peptidylprolyl isomerase B	Homo sapiens	209-213
19361221-5	2009	Here we have modeled the interaction of ERK with a target peptide and analyzed the specificity toward Ser/Thr-Pro motifs.	Proline	110-113	mitogen-activated protein kinase 1	Homo sapiens	40-43
19451596-7	2009	Subjects carrying the TP53 Arg72Pro polymorphism were found to have a significantly increased death risk (Pro/Pro versus Arg/Arg; hazard ratio, 2.90; 95% CI, 1.28-6.66).	Proline	32-35	tumor protein p53	Homo sapiens	22-26
19451596-7	2009	Subjects carrying the TP53 Arg72Pro polymorphism were found to have a significantly increased death risk (Pro/Pro versus Arg/Arg; hazard ratio, 2.90; 95% CI, 1.28-6.66).	Proline	106-109	tumor protein p53	Homo sapiens	22-26
19451596-8	2009	In the subgroup of 130 high-grade osteosarcomas, the TP53 Arg72Pro was an independent marker of EFS (Pro/Pro versus Arg/Arg; hazard ratio, 2.67; 95% CI, 1.17-6.11).	Proline	63-66	tumor protein p53	Homo sapiens	53-57
19451596-8	2009	In the subgroup of 130 high-grade osteosarcomas, the TP53 Arg72Pro was an independent marker of EFS (Pro/Pro versus Arg/Arg; hazard ratio, 2.67; 95% CI, 1.17-6.11).	Proline	101-104	tumor protein p53	Homo sapiens	53-57
19371038-3	2009	Proline, a common P2 in many thrombin inhibitors, was combined with known P3 residues and P1 substituents of varying size and lipophilicity.	Proline	0-7	coagulation factor II, thrombin	Homo sapiens	29-37
19304660-5	2009	The effect of Cav-1 on ENaC requires the proline-rich motifs at the C termini of the beta- and gamma-subunits of ENaC, the binding motifs that mediate interaction with Nedd4-2.	Proline	41-48	caveolin 1	Homo sapiens	14-19
19304660-5	2009	The effect of Cav-1 on ENaC requires the proline-rich motifs at the C termini of the beta- and gamma-subunits of ENaC, the binding motifs that mediate interaction with Nedd4-2.	Proline	41-48	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	168-175
19167777-5	2009	We found that over-expression of HSP26 in Arabidopsis increased the amounts of free proline and soluble sugars, elevated the expression of stress defense genes, and enhanced Arabidopsis tolerance to freezing stress.	Proline	84-91	chaperone protein HSP26	Saccharomyces cerevisiae S288C	33-38
19322200-7	2009	This constitutive activity results from an unconventional residue, Leu(222), in place of a conserved proline in transmembrane domain six; a Cpr2(L222P) mutant is no longer constitutively active.	Proline	101-108	peptidylprolyl isomerase CPR2	Saccharomyces cerevisiae S288C	140-144
19361221-7	2009	Our results suggest that (1) the proline residue has a role in both specificity and phospho transfer efficiency, (2) the reaction occurs in one step, with ERK2 Asp(147) acting as the catalytic base, (3) a conserved Lys in the kinase superfamily that is usually mutated to check kinase activity strongly stabilizes the transition state, and (4) the reaction mechanism is similar with either one or two Mg(2+) ions in the active site.	Proline	33-40	mitogen-activated protein kinase 1	Homo sapiens	155-159
19345263-4	2009	LAIR-1 specifically interacts with synthetic trimeric peptides containing 10 repeats of glycine-proline-hydroxyproline (GPO) residues which can directly inhibit immune cell activation in vitro.	Proline	96-103	leukocyte associated immunoglobulin like receptor 1	Homo sapiens	0-6
19402731-3	2009	Studies showed that BChE subunits can be assembled by a peptide containing the proline-rich attachment domain (PRAD) to form a stable tetramer.	Proline	79-86	butyrylcholinesterase	Homo sapiens	20-24
19538297-9	2009	However, all patients had a single nucleotide substitution of C for T at the position of 451 of claudin-8 gene sequence that changes amino acid residue from serine to proline at the position of 151 in the second extracellular domain of claudin-8 protein.	Proline	167-174	claudin 8	Homo sapiens	96-105
19538297-9	2009	However, all patients had a single nucleotide substitution of C for T at the position of 451 of claudin-8 gene sequence that changes amino acid residue from serine to proline at the position of 151 in the second extracellular domain of claudin-8 protein.	Proline	167-174	claudin 8	Homo sapiens	236-245
19258192-6	2009	The slow refolding step could be partly attributed to proline isomerization, based on an increased rate during refolding in the presence of PPIase and an increased relative amplitude of this step with increasing delay time in double-jump refolding experiments observed over delays of 5-100 s. However, double-jump refolding experiments with delay times longer than 100 s along with size exclusion chromatography and dynamic light scattering of refolding samples showed that the overall refolding yield decreased as bhx was unfolded for longer periods of time.	Proline	54-61	FKBP prolyl isomerase 1B	Homo sapiens	140-146
19269308-2	2009	This mutation changes a highly conserved leucine to proline in the Atp6p subunit of the ATP synthase, at position 156 in the human protein, position 183 in yeast.	Proline	52-59	mitochondrially encoded ATP synthase 6	Homo sapiens	67-72
18698640-2	2009	It is shown in this work that the chiral-induced equilibrium shift of [Tb(CDA)3](6-) by L-amino acids (i.e. L-proline or L-arginine) was largely influenced by the hydrogen-bonding networks formed between the ligand interface of racemic [Tb(CDA)3](6-) and these added chiral agents.	Proline	108-117	CDAN3	Homo sapiens	74-79
18698640-2	2009	It is shown in this work that the chiral-induced equilibrium shift of [Tb(CDA)3](6-) by L-amino acids (i.e. L-proline or L-arginine) was largely influenced by the hydrogen-bonding networks formed between the ligand interface of racemic [Tb(CDA)3](6-) and these added chiral agents.	Proline	108-117	CDAN3	Homo sapiens	240-245
18698640-3	2009	The capping of potential hydrogen-bonding sites by acetylation in L-proline led to a approximately 100-fold drop in the induced optical activity of the [Tb(CDA)3](6-):N-acetyl-L-proline system.	Proline	66-75	CDAN3	Homo sapiens	156-161
19383811-7	2009	p53 Pro/Pro was strongly associated with shorter survival in the entire cohort (MS of 11.8 versus 29.1 months, P &lt; 0.0001; adjusted hazard ratio for death, 2.05; 95% confidence interval, 1.30-3.24; P = 0.002 for Pro/Pro versus Arg/Arg).	Proline	4-7	tumor protein p53	Homo sapiens	0-3
19383811-7	2009	p53 Pro/Pro was strongly associated with shorter survival in the entire cohort (MS of 11.8 versus 29.1 months, P &lt; 0.0001; adjusted hazard ratio for death, 2.05; 95% confidence interval, 1.30-3.24; P = 0.002 for Pro/Pro versus Arg/Arg).	Proline	8-11	tumor protein p53	Homo sapiens	0-3
19434769-4	2009	p53 protein contains a transactivation domain, a sequence-specific DNA binding domain, a tetramerization domain, a non-specific DNA binding domain that recognizes damaged DNA, and a later identified proline-rich domain.	Proline	199-206	tumor protein p53	Homo sapiens	0-3
19166927-3	2009	The interaction is mediated by the SH3A domain of ITSN1 and the third or fourth proline-rich blocks of Ruk/CIN85, and does not depend on epidermal growth factor stimulation, suggesting a constitutive association of ITSN1 with Ruk/CIN85.	Proline	80-87	SH3 domain containing kinase binding protein 1	Homo sapiens	107-112
19166927-3	2009	The interaction is mediated by the SH3A domain of ITSN1 and the third or fourth proline-rich blocks of Ruk/CIN85, and does not depend on epidermal growth factor stimulation, suggesting a constitutive association of ITSN1 with Ruk/CIN85.	Proline	80-87	intersectin 1	Homo sapiens	215-220
19166927-3	2009	The interaction is mediated by the SH3A domain of ITSN1 and the third or fourth proline-rich blocks of Ruk/CIN85, and does not depend on epidermal growth factor stimulation, suggesting a constitutive association of ITSN1 with Ruk/CIN85.	Proline	80-87	SH3 domain containing kinase binding protein 1	Homo sapiens	230-235
19343042-1	2009	Cyclin-dependent kinase 5 (CDK5), a proline-directed serine/threonine kinase, which was originally known for its regulatory role in neuronal activities, has recently been suggested to play a role in extraneuronal activities.	Proline	36-43	cyclin dependent kinase 5	Homo sapiens	0-25
19343042-1	2009	Cyclin-dependent kinase 5 (CDK5), a proline-directed serine/threonine kinase, which was originally known for its regulatory role in neuronal activities, has recently been suggested to play a role in extraneuronal activities.	Proline	36-43	cyclin dependent kinase 5	Homo sapiens	27-31
19240036-1	2009	System A transporters SNAT1 and SNAT2 mediate uptake of neutral alpha-amino acids (e.g. glutamine, alanine, and proline) and are expressed in central neurons.	Proline	112-119	solute carrier family 38 member 2	Homo sapiens	32-37
19417147-5	2009	Melittin is synthesized as promelittin, containing a 22 amino acid NH(2)-terminal prodomain rich in the amino acids proline and alanine.	Proline	116-123	melittin	Apis mellifera	0-8
19218568-5	2009	Here, we chemically synthesized the Vif CTD using pseudo-proline-building blocks, studied its solution structure in the unbound state using biophysical techniques and found that it is unstructured under physiological conditions.	Proline	57-64	Vif	Human immunodeficiency virus 1	36-39
19218568-5	2009	Here, we chemically synthesized the Vif CTD using pseudo-proline-building blocks, studied its solution structure in the unbound state using biophysical techniques and found that it is unstructured under physiological conditions.	Proline	57-64	CTD	Homo sapiens	40-43
19372727-7	2009	p47phox is a 390 amino acids protein with several functional domains: one phox homology (PX) domain, two src homology 3 (SH3) domains, an auto-inhibitory region (AIR), a proline rich domain (PRR) and has several phosphorylated sites located between Ser303 and Ser379.	Proline	170-177	neutrophil cytosolic factor 1	Homo sapiens	0-7
19261613-9	2009	Comparison of AtClC-a and ClC-5 sequences identified a proline in AtClC-a that is replaced by serine in all mammalian CLC isoforms.	Proline	55-62	chloride channel A	Arabidopsis thaliana	14-21
19261613-9	2009	Comparison of AtClC-a and ClC-5 sequences identified a proline in AtClC-a that is replaced by serine in all mammalian CLC isoforms.	Proline	55-62	chloride voltage-gated channel 5	Homo sapiens	26-31
19261613-9	2009	Comparison of AtClC-a and ClC-5 sequences identified a proline in AtClC-a that is replaced by serine in all mammalian CLC isoforms.	Proline	55-62	chloride channel A	Arabidopsis thaliana	66-73
19240036-1	2009	System A transporters SNAT1 and SNAT2 mediate uptake of neutral alpha-amino acids (e.g. glutamine, alanine, and proline) and are expressed in central neurons.	Proline	112-119	solute carrier family 38 member 1	Homo sapiens	22-27
19261613-10	2009	When this proline was mutated to serine (P160S), Cl(-)/H(+) exchange of AtClC-a proceeded as efficiently as NO(3)(-)/H(+) exchange, suggesting a role of this residue in NO(3)(-)/H(+) exchange.	Proline	10-17	chloride channel A	Arabidopsis thaliana	72-79
19261613-9	2009	Comparison of AtClC-a and ClC-5 sequences identified a proline in AtClC-a that is replaced by serine in all mammalian CLC isoforms.	Proline	55-62	Charcot-Leyden crystal galectin	Homo sapiens	118-121
19383978-3	2009	This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms.	Proline	68-75	mechanistic target of rapamycin kinase	Homo sapiens	5-9
19261613-11	2009	Indeed, when the corresponding serine of ClC-5 was replaced by proline, this Cl(-)/H(+) exchanger gained efficient NO(3)(-)/H(+) coupling.	Proline	63-70	chloride voltage-gated channel 5	Homo sapiens	41-46
19261613-13	2009	Hence, proline in the CLC pore signature sequence is important for NO(3)(-)/H(+) exchange and NO(3)(-) conductance both in plants and mammals.	Proline	7-14	Charcot-Leyden crystal galectin	Homo sapiens	22-25
19383978-3	2009	This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms.	Proline	68-75	AKT serine/threonine kinase 1	Homo sapiens	132-135
19268472-3	2009	To understand the manifold interactions of CIN85, we present a detailed high-resolution solution structural study of CIN85A and CIN85B binding to proline-arginine peptides derived from the cognate ligands Cbl and Cbl-b.	Proline	146-153	SH3 domain containing kinase binding protein 1	Homo sapiens	43-48
19268472-3	2009	To understand the manifold interactions of CIN85, we present a detailed high-resolution solution structural study of CIN85A and CIN85B binding to proline-arginine peptides derived from the cognate ligands Cbl and Cbl-b.	Proline	146-153	Cbl proto-oncogene	Homo sapiens	205-208
19208620-8	2009	Four amino acid residues (i.e. Tyr-182, Glu-188, Pro-189, and Ser-192) are especially important for FEN1 stimulatory activity.	Proline	49-52	flap structure-specific endonuclease 1	Homo sapiens	100-104
19211556-11	2009	Thus, only the concomitant mutations of Thr(97) and Pro(101) induce the conformational changes necessary to produce catalytically efficient, glyphosate-resistant class I EPSPS.	Proline	52-55	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	170-175
19331814-0	2009	New function of the proline rich domain in dynamin-2 to negatively regulate its interaction with microtubules in mammalian cells.	Proline	20-27	dynamin 2	Homo sapiens	43-52
19342663-5	2009	Additional experiments show that the membrane proximal basic amino acid rich sequence in the IC domain of CD3epsilon is sufficient for the DN to DP differentiation, whereas the proline rich sequence is required for efficient proliferation.	Proline	177-184	CD3 antigen, epsilon polypeptide	Mus musculus	106-116
19342663-6	2009	This is probably due to impaired ligand independent recruitment of Nck to the proline rich sequence motif of CD3epsilon within the context of the preTCR.	Proline	78-85	non-catalytic region of tyrosine kinase adaptor protein 1	Mus musculus	67-70
19342663-6	2009	This is probably due to impaired ligand independent recruitment of Nck to the proline rich sequence motif of CD3epsilon within the context of the preTCR.	Proline	78-85	CD3 antigen, epsilon polypeptide	Mus musculus	109-119
19368807-0	2009	Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: an inductive effect of neuron differentiation.	Proline	30-37	proline rich membrane anchor 1	Homo sapiens	60-65
19368807-0	2009	Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: an inductive effect of neuron differentiation.	Proline	30-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-104
19368807-1	2009	The transcriptional regulation of proline-rich membrane anchor (PRiMA), an anchoring protein of tetrameric globular form of acetylcholinesterase (G(4) AChE), was revealed in cultured cortical neurons during differentiation.	Proline	34-41	proline rich membrane anchor 1	Homo sapiens	64-69
19361414-0	2009	Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain.	Proline	0-7	IL2 inducible T cell kinase	Homo sapiens	73-76
19368807-1	2009	The transcriptional regulation of proline-rich membrane anchor (PRiMA), an anchoring protein of tetrameric globular form of acetylcholinesterase (G(4) AChE), was revealed in cultured cortical neurons during differentiation.	Proline	34-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	124-144
19368807-1	2009	The transcriptional regulation of proline-rich membrane anchor (PRiMA), an anchoring protein of tetrameric globular form of acetylcholinesterase (G(4) AChE), was revealed in cultured cortical neurons during differentiation.	Proline	34-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	151-155
19361414-0	2009	Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain.	Proline	0-7	IL2 inducible T cell kinase	Homo sapiens	39-42
19357277-0	2009	Targeting of acetylcholinesterase in neurons in vivo: a dual processing function for the proline-rich membrane anchor subunit and the attachment domain on the catalytic subunit.	Proline	89-96	acetylcholinesterase	Mus musculus	13-33
19357277-1	2009	Acetylcholinesterase (AChE) accumulates on axonal varicosities and is primarily found as tetramers associated with a proline-rich membrane anchor (PRiMA).	Proline	117-124	acetylcholinesterase	Mus musculus	0-20
19357277-1	2009	Acetylcholinesterase (AChE) accumulates on axonal varicosities and is primarily found as tetramers associated with a proline-rich membrane anchor (PRiMA).	Proline	117-124	acetylcholinesterase	Mus musculus	22-26
19357277-1	2009	Acetylcholinesterase (AChE) accumulates on axonal varicosities and is primarily found as tetramers associated with a proline-rich membrane anchor (PRiMA).	Proline	117-124	proline rich membrane anchor 1	Mus musculus	147-152
19208626-0	2009	Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline.	Proline	123-130	endothelial PAS domain protein 1	Homo sapiens	26-36
19592546-1	2009	Phosphorylation of proteins on serine or threonine residues preceding proline is a major regulatory mechanism in cell proliferation and transformation, which is catalyzed specifically by Pin1, a peptidylprolyl isomerase.	Proline	70-77	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	187-191
19139049-7	2009	This exon also encodes for a majority of the SEPT9 N-terminal proline rich region suggesting that this region plays a role in the pathogenesis of HNA.	Proline	62-69	septin 9	Homo sapiens	45-50
19090718-4	2009	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis, mass spectrometry, and N-terminal sequence analyses show that KLK9 and 10 exhibit low hydrolytic activities towards all of the 15 pro-KLK sequences, while KLK15 exhibits significant activity towards both Arg- and Lys-containing KLK pro-sequences.	Proline	189-192	kallikrein related peptidase 9	Homo sapiens	121-125
19291099-1	2009	Pin1 plays a key role in various biological cellular processes via the recognition of phosphorylated Ser/Thr-Proline motifs.	Proline	109-116	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
19224453-3	2009	Structurally, FAK consists of an amino-terminal regulatory FERM domain, a central catalytic kinase domain, two proline-rich motifs, and a carboxy-terminal focal adhesion targeting domain.	Proline	111-118	protein tyrosine kinase 2	Homo sapiens	14-17
19155119-0	2009	Effect of proline on thermal inactivation, denaturation and aggregation of glycogen phosphorylase b from rabbit skeletal muscle.	Proline	10-17	LOW QUALITY PROTEIN: glycogen phosphorylase, brain form	Oryctolagus cuniculus	75-99
19155119-1	2009	It has been shown that the relatively low concentrations of proline (0.1 M) have a slight accelerating effect on thermal aggregation of glycogen phosphorylase b (Phb) from rabbit skeletal muscle registered by the accumulaton of the aggregated protein.	Proline	60-67	LOW QUALITY PROTEIN: glycogen phosphorylase, brain form	Oryctolagus cuniculus	136-160
19168580-1	2009	Phosphorylation of proteins on serine or threonine residues that immediately precede proline (pSer/Thr-Pro) is specifically catalyzed by the peptidyl-prolyl cis-trans isomerase Pin1 and is a central signaling mechanism in cell proliferation and transformation.	Proline	85-92	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	177-181
19318583-6	2009	From analyses using deletion mutants of ZNF312b and K-ras promoter-driven luciferase reporters, we found that it translocates into the nucleus via the proline-rich domain of its COOH terminus to activate transcription of the K-ras gene, resulting in an enhancement of the extracellular signal-regulated kinase signaling pathway that governs cell proliferation.	Proline	151-158	FEZ family zinc finger 1	Homo sapiens	40-47
19318583-6	2009	From analyses using deletion mutants of ZNF312b and K-ras promoter-driven luciferase reporters, we found that it translocates into the nucleus via the proline-rich domain of its COOH terminus to activate transcription of the K-ras gene, resulting in an enhancement of the extracellular signal-regulated kinase signaling pathway that governs cell proliferation.	Proline	151-158	KRAS proto-oncogene, GTPase	Homo sapiens	52-57
19318583-6	2009	From analyses using deletion mutants of ZNF312b and K-ras promoter-driven luciferase reporters, we found that it translocates into the nucleus via the proline-rich domain of its COOH terminus to activate transcription of the K-ras gene, resulting in an enhancement of the extracellular signal-regulated kinase signaling pathway that governs cell proliferation.	Proline	151-158	KRAS proto-oncogene, GTPase	Homo sapiens	225-230
19074508-6	2009	When compared to the isolated MT binding repeats (K(d)=0.3 microM), the phospho-Tau retains a substantial affinity for preformed MTs (K(d)=11 nM), suggesting that the phosphorylated proline-rich region still participates in the binding event.	Proline	182-189	microtubule associated protein tau	Homo sapiens	80-83
19267429-3	2009	We studied the cis-trans isomerization of the proline dipeptide (Ace-Pro-NMe) in explicit water by molecular dynamics simulations using a combined potential derived from ab initio quantum mechanics and empirical molecular mechanics.	Proline	46-53	angiotensin I converting enzyme	Homo sapiens	65-68
19267471-12	2009	The combination of NMR and ITC data sheds light on how the Fyn tyrosine kinase is activated by binding to proline-rich targets, and represents a powerful approach for characterizing transient protein/ligand interactions.	Proline	106-113	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-62
19307613-8	2009	The increased rate of hydrolysis by plasmin toward the cleavage site Lys(68)-Ser(69) has to be ascribed to the elevated proline content of the peptide 61-73.	Proline	120-127	plasminogen	Bos taurus	36-43
19403918-1	2009	To detect interactions of different proline-rich ligands with profilins, the authors developed a simple analytical antibody-based screening method.	Proline	36-43	profilin 1	Homo sapiens	62-71
19047760-8	2009	The N-terminal proline-rich and C-terminal hydrophobic domains of H-Rev107 were earlier reported to be responsible for the regulation of cell proliferation.	Proline	15-22	phospholipase A and acyltransferase 3	Rattus norvegicus	66-74
19147495-6	2009	The substrate profile of the NTT4/XT1-dependent activity is similar to that of the closely related B(0)AT2/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low millimolar apparent affinity for glutamine.	Proline	172-179	solute carrier family 6 member 17	Homo sapiens	29-33
19157940-7	2009	A typical Smad consists of a conserved N-terminal Mad Homology 1 (MH1) domain and a C-terminal Mad Homology 2 (MH2) domain connected by a proline rich linker.	Proline	138-145	Smad on X	Drosophila melanogaster	10-14
19188446-2	2009	The unusual structural homology between MIF and certain tautomerases, which includes both a conserved substrate-binding pocket and a catalytic N-terminal proline (Pro1), has fueled speculation that an enzymatic reaction underlies MIF"s biologic function.	Proline	154-161	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	40-43
19188446-2	2009	The unusual structural homology between MIF and certain tautomerases, which includes both a conserved substrate-binding pocket and a catalytic N-terminal proline (Pro1), has fueled speculation that an enzymatic reaction underlies MIF"s biologic function.	Proline	154-161	proline dehydrogenase	Mus musculus	163-167
19188446-2	2009	The unusual structural homology between MIF and certain tautomerases, which includes both a conserved substrate-binding pocket and a catalytic N-terminal proline (Pro1), has fueled speculation that an enzymatic reaction underlies MIF"s biologic function.	Proline	154-161	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	230-233
19109251-6	2009	Unlike previous reports for the EGF RTK, which requires the Eps15 ubiquitin interacting motif, recruitment of Eps15 to Met involves the coiled-coil domain of Eps15 and the signaling adaptor molecule, Grb2, which binds through a proline-rich motif in the third domain of Eps15.	Proline	228-235	epidermal growth factor receptor pathway substrate 15	Homo sapiens	110-115
19109251-6	2009	Unlike previous reports for the EGF RTK, which requires the Eps15 ubiquitin interacting motif, recruitment of Eps15 to Met involves the coiled-coil domain of Eps15 and the signaling adaptor molecule, Grb2, which binds through a proline-rich motif in the third domain of Eps15.	Proline	228-235	epidermal growth factor receptor pathway substrate 15	Homo sapiens	110-115
19109251-6	2009	Unlike previous reports for the EGF RTK, which requires the Eps15 ubiquitin interacting motif, recruitment of Eps15 to Met involves the coiled-coil domain of Eps15 and the signaling adaptor molecule, Grb2, which binds through a proline-rich motif in the third domain of Eps15.	Proline	228-235	growth factor receptor bound protein 2	Homo sapiens	200-204
19109251-6	2009	Unlike previous reports for the EGF RTK, which requires the Eps15 ubiquitin interacting motif, recruitment of Eps15 to Met involves the coiled-coil domain of Eps15 and the signaling adaptor molecule, Grb2, which binds through a proline-rich motif in the third domain of Eps15.	Proline	228-235	epidermal growth factor receptor pathway substrate 15	Homo sapiens	110-115
19288014-2	2009	The conformation and function of phosphorylated Ser/Thr-Pro motifs are further regulated by the prolyl isomerase Pin1.	Proline	56-59	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	113-117
19360123-1	2009	Macrophage-specific expression of Arginase-1 is commonly believed to promote inflammation, fibrosis, and wound healing by enhancing L-proline, polyamine, and Th2 cytokine production.	Proline	132-141	arginase, liver	Mus musculus	34-44
19185292-1	2009	We describe the synthesis of two glucose-templated proline-lysine chimeras (GlcTProLysCs) that differ in the stereochemistry of the hydroxymethyl substituent at the C-5" position of the pyrrolidine ring.	Proline	51-58	complement C5	Homo sapiens	165-168
19147495-6	2009	The substrate profile of the NTT4/XT1-dependent activity is similar to that of the closely related B(0)AT2/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low millimolar apparent affinity for glutamine.	Proline	172-179	xylosyltransferase 1	Homo sapiens	34-37
19147495-6	2009	The substrate profile of the NTT4/XT1-dependent activity is similar to that of the closely related B(0)AT2/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low millimolar apparent affinity for glutamine.	Proline	172-179	solute carrier family 6 member 15	Homo sapiens	107-112
19147495-6	2009	The substrate profile of the NTT4/XT1-dependent activity is similar to that of the closely related B(0)AT2/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low millimolar apparent affinity for glutamine.	Proline	172-179	solute carrier family 6 member 15	Homo sapiens	114-121
19168184-3	2009	These results have been interpreted in terms of on-column cis-trans isomerization of angiotensin I (a proline containing polypeptide) followed by its "re-conformation" after the interaction with the support.	Proline	102-109	angiotensinogen	Homo sapiens	85-98
19428830-5	2009	Furthermore, substitution of the proline residues of indolicidin with arginine increased the synergistic adjuvant effect of the peptide, and induced significantly higher IgG1 and IgG2a titers and IFN-gamma secretion, as well as increased uptake by antigen presenting cells.	Proline	33-40	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	170-174
19428830-5	2009	Furthermore, substitution of the proline residues of indolicidin with arginine increased the synergistic adjuvant effect of the peptide, and induced significantly higher IgG1 and IgG2a titers and IFN-gamma secretion, as well as increased uptake by antigen presenting cells.	Proline	33-40	immunoglobulin heavy variable V1-9	Mus musculus	179-184
19428830-5	2009	Furthermore, substitution of the proline residues of indolicidin with arginine increased the synergistic adjuvant effect of the peptide, and induced significantly higher IgG1 and IgG2a titers and IFN-gamma secretion, as well as increased uptake by antigen presenting cells.	Proline	33-40	interferon gamma	Mus musculus	196-205
19032151-0	2009	A single conserved proline residue determines the membrane topology of stomatin.	Proline	19-26	PHB domain-containing protein;Stomatin-1	Caenorhabditis elegans	71-79
18983987-8	2009	The substitution of tryptophan for proline in hCBR3 failed to affect the enzymatic characteristics.	Proline	35-42	carbonyl reductase 3	Homo sapiens	46-51
18983987-9	2009	Similarly, the substitution of proline for tryptophan in either Chinese hamster CBR3 (CHCR3) or rCBR3 showed no significant change in the catalytic properties.	Proline	31-38	carbonyl reductase [NADPH] 3	Cricetulus griseus	80-84
18983987-6	2009	Compared with the amino acid sequences of CBR1 and CBR3 among humans, rats, Chinese hamsters, and mice, the tryptophan residue at position 230 is highly conserved while human CBR3 possesses rigid amino acid, proline, at that position instead.	Proline	208-215	carbonyl reductase 3	Homo sapiens	175-179
19032151-7	2009	The highly conserved proline residue is crucial for adopting the hairpin-loop topology: substitution of this proline residue by serine transfers the whole stomatin pool to the single-pass transmembrane form, which no longer localizes to DRMs.	Proline	21-28	PHB domain-containing protein;Stomatin-1	Caenorhabditis elegans	155-163
18983987-9	2009	Similarly, the substitution of proline for tryptophan in either Chinese hamster CBR3 (CHCR3) or rCBR3 showed no significant change in the catalytic properties.	Proline	31-38	carbonyl reductase [NADPH] 3	Cricetulus griseus	86-91
18983987-9	2009	Similarly, the substitution of proline for tryptophan in either Chinese hamster CBR3 (CHCR3) or rCBR3 showed no significant change in the catalytic properties.	Proline	31-38	carbonyl reductase 3	Rattus norvegicus	96-101
19032151-7	2009	The highly conserved proline residue is crucial for adopting the hairpin-loop topology: substitution of this proline residue by serine transfers the whole stomatin pool to the single-pass transmembrane form, which no longer localizes to DRMs.	Proline	109-116	PHB domain-containing protein;Stomatin-1	Caenorhabditis elegans	155-163
19061875-9	2009	In particular, when nine residues (236-244) in the vicinity of the catalytic center and a proline (P230) in CBR3 were mutated to the corresponding residues of CBR1 a much higher k(cat)/K(m) value (5.7 microM(-1)min(-1)) towards isatin was observed.	Proline	90-97	carbonyl reductase 3	Homo sapiens	108-112
19452600-0	2009	A generic mechanism of beta2-microglobulin amyloid assembly at neutral pH involving a specific proline switch.	Proline	95-102	beta-2-microglobulin	Homo sapiens	23-42
19061875-9	2009	In particular, when nine residues (236-244) in the vicinity of the catalytic center and a proline (P230) in CBR3 were mutated to the corresponding residues of CBR1 a much higher k(cat)/K(m) value (5.7 microM(-1)min(-1)) towards isatin was observed.	Proline	90-97	carbonyl reductase 1	Homo sapiens	159-163
18930563-3	2009	When growing on media with NaCl or mannitol, the ZmPP2C-overexpressed plants displayed more severe damages, with weaker growth phenotypes corresponding to a series of physiological changes: lower net photosynthesis rate (Pn) and free proline content, higher malondialdehyde (MDA) level, higher relative membrane permeability (RMP), and water loss.	Proline	234-241	Probable protein phosphatase 2C 10	Zea mays	49-55
19240114-5	2009	OAP formation was also prevented by introducing proline residues at sites just downstream from the hydrophobic N-terminus of AQP4-M23.	Proline	48-55	aquaporin 4	Homo sapiens	125-129
19154138-0	2009	The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.	Proline	4-11	protein phosphatase 3 catalytic subunit beta	Homo sapiens	40-57
19452600-3	2009	Here, we have used site-directed mutagenesis to create five proline to glycine variants in the naturally amyloidogenic protein beta2-microglobulin (beta2m).	Proline	60-67	beta-2-microglobulin	Homo sapiens	127-146
19452600-3	2009	Here, we have used site-directed mutagenesis to create five proline to glycine variants in the naturally amyloidogenic protein beta2-microglobulin (beta2m).	Proline	60-67	beta-2-microglobulin	Homo sapiens	148-154
19452600-9	2009	In this mechanism, amyloid formation is initiated by a specific cis to trans proline switch, the rate of which we show to be controlled by the amino acid sequence proximal to P32 and to the applied solution conditions.	Proline	77-84	inhibitor of growth family member 2	Homo sapiens	175-178
19255483-2	2009	It contains three predicted domains: an N-terminal acid and proline-rich domain, a transmembrane voltage-sensor domain and a C-terminal domain that is responsible for the dimeric architecture of Hv1.	Proline	60-67	hydrogen voltage gated channel 1	Homo sapiens	195-198
19269366-2	2009	We now provide evidence that one of these proteins, TANGO1, is an integral membrane protein localized to endoplasmic reticulum (ER) exit sites, with a luminal SH3 domain and a cytoplasmic proline-rich domain (PRD).	Proline	188-195	MIA SH3 domain ER export factor 3	Homo sapiens	52-58
19217790-4	2009	DPP-4, a protease that specifically cleaves dipeptides from proteins and oligopeptides after a penultimate N-terminal proline or alanine, is involved in the degradation of a number of neuropeptides, peptide hormones and cytokines, including the incretins GLP-1 and GIP.	Proline	118-125	dipeptidyl peptidase 4	Homo sapiens	0-5
18974271-2	2009	The Wwox protein contains two N-terminal WW domains that interact with several transcriptional activators containing proline-tyrosine motifs and a central short-chain dehydrogenase/reductase domain that has been suggested to play a role in steroid metabolism.	Proline	117-124	WW domain-containing oxidoreductase	Mus musculus	4-8
18798003-7	2009	In heavy-smokers, the combination of NQO1 Pro/Ser + Ser/Ser and CYP2E1 c1/c1 genotype was associated with a significantly increased risk for lung cancer (OR = 2.25, 95% CI = 1.14-4.43) compared with those of NQO1 Pro/Pro and CYP2E1 c1/c2 + c2/c2 genotype.	Proline	42-45	NAD(P)H quinone dehydrogenase 1	Homo sapiens	37-41
18930841-8	2009	Both phosphorylated FAK residue Y397 and FAK proline-rich domain are involved in Fyn binding.	Proline	45-52	protein tyrosine kinase 2	Homo sapiens	41-44
18930841-8	2009	Both phosphorylated FAK residue Y397 and FAK proline-rich domain are involved in Fyn binding.	Proline	45-52	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	81-84
18665424-0	2009	Imaging of fibrogenesis in patients with idiopathic pulmonary fibrosis with cis-4-[(18)F]-Fluoro-L: -proline PET.	Proline	101-108	suppressor of cytokine signaling 6	Homo sapiens	76-81
19290936-1	2009	The proline-, glutamic acid-, serine- and threonine-rich (PEST) family of protein tyrosine phosphatases (PTPs) includes proline-enriched phosphatase (PEP)/lymphoid tyrosine phosphatase (LYP), PTP-PEST, and PTP-hematopoietic stem cell fraction (HSCF).	Proline	4-11	prolyl endopeptidase	Homo sapiens	120-148
19290936-1	2009	The proline-, glutamic acid-, serine- and threonine-rich (PEST) family of protein tyrosine phosphatases (PTPs) includes proline-enriched phosphatase (PEP)/lymphoid tyrosine phosphatase (LYP), PTP-PEST, and PTP-hematopoietic stem cell fraction (HSCF).	Proline	4-11	prolyl endopeptidase	Homo sapiens	150-153
19290936-1	2009	The proline-, glutamic acid-, serine- and threonine-rich (PEST) family of protein tyrosine phosphatases (PTPs) includes proline-enriched phosphatase (PEP)/lymphoid tyrosine phosphatase (LYP), PTP-PEST, and PTP-hematopoietic stem cell fraction (HSCF).	Proline	4-11	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	186-189
19290936-1	2009	The proline-, glutamic acid-, serine- and threonine-rich (PEST) family of protein tyrosine phosphatases (PTPs) includes proline-enriched phosphatase (PEP)/lymphoid tyrosine phosphatase (LYP), PTP-PEST, and PTP-hematopoietic stem cell fraction (HSCF).	Proline	4-11	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	192-200
19290936-1	2009	The proline-, glutamic acid-, serine- and threonine-rich (PEST) family of protein tyrosine phosphatases (PTPs) includes proline-enriched phosphatase (PEP)/lymphoid tyrosine phosphatase (LYP), PTP-PEST, and PTP-hematopoietic stem cell fraction (HSCF).	Proline	4-11	protein tyrosine phosphatase receptor type U	Homo sapiens	105-108
19116236-5	2009	Sequencing of the CYP11B2 gene showed that affected subjects were homozygous for a single nucleotide substitution (T925C) in exon 5, corresponding to a serine to proline mutation (S308P) in the predicted protein, with unaffected family members being heterozygous.	Proline	162-169	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	18-25
19089804-1	2009	CLA, a natural, highly hydrophobic cyclic nonapeptide with sequence c(Pro(1)-Pro(2)-Phe(3)-Phe(4)-Leu(5)-Ile(6)-Ile(7)-Leu(8)-Val(9)-), isolated from linseed oil, was found to possess a strong immunosuppressive activity comparable, in low doses, with that of CsA, with a mechanism that depends on the inhibition of the interleukin-1 and interleukin-2 action.	Proline	70-73	clasper	Mus musculus	0-3
18665424-2	2009	Cis-4-(18)F-fluoro-L: -proline ((18)F-proline) was shown in animal studies to be a reliable marker for fibrosis formation.	Proline	23-30	suppressor of cytokine signaling 6	Homo sapiens	0-5
18665424-2	2009	Cis-4-(18)F-fluoro-L: -proline ((18)F-proline) was shown in animal studies to be a reliable marker for fibrosis formation.	Proline	38-45	suppressor of cytokine signaling 6	Homo sapiens	0-5
19158383-5	2009	In addition to the cysteine-rich domain, proline-117 is also essential for SNAP25 membrane binding, and experiments in HEK293 cells revealed that mutation of this residue inhibits membrane binding induced by coexpression with DHHC17, but not DHHC3 or DHHC7.	Proline	41-48	synaptosome associated protein 25	Homo sapiens	75-81
19116316-2	2009	AIP4 belongs to the Nedd4-like homologous to E6-AP carboxy terminus domain family of E3 ubiquitin ligases, which typically bind proline-rich motifs within target proteins via the WW domains.	Proline	128-135	itchy E3 ubiquitin protein ligase	Homo sapiens	0-4
19116316-2	2009	AIP4 belongs to the Nedd4-like homologous to E6-AP carboxy terminus domain family of E3 ubiquitin ligases, which typically bind proline-rich motifs within target proteins via the WW domains.	Proline	128-135	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	20-25
19116316-2	2009	AIP4 belongs to the Nedd4-like homologous to E6-AP carboxy terminus domain family of E3 ubiquitin ligases, which typically bind proline-rich motifs within target proteins via the WW domains.	Proline	128-135	ubiquitin protein ligase E3A	Homo sapiens	45-50
19124609-3	2009	Here we report that a proline-rich domain in Blimp-1 directly interacts with LSD1, a histone lysine demethylase.	Proline	22-29	PR/SET domain 1	Homo sapiens	45-52
19124609-3	2009	Here we report that a proline-rich domain in Blimp-1 directly interacts with LSD1, a histone lysine demethylase.	Proline	22-29	lysine demethylase 1A	Homo sapiens	77-81
19124609-4	2009	Both LSD1 knockdown and expression of Blimp-1 lacking the proline-rich domain derepressed the activities of Blimp-1-dependent luciferase reporters.	Proline	58-65	PR/SET domain 1	Homo sapiens	38-45
19129478-2	2009	p47(phox) and p67(phox) are linked via a high-affinity, tail-to-tail interaction involving a proline-rich region (PRR) and a C-terminal SH3 domain (SH3b), respectively, in their C-termini.	Proline	93-100	pleckstrin	Homo sapiens	0-3
19129478-2	2009	p47(phox) and p67(phox) are linked via a high-affinity, tail-to-tail interaction involving a proline-rich region (PRR) and a C-terminal SH3 domain (SH3b), respectively, in their C-termini.	Proline	93-100	pleckstrin	Homo sapiens	4-8
19129478-2	2009	p47(phox) and p67(phox) are linked via a high-affinity, tail-to-tail interaction involving a proline-rich region (PRR) and a C-terminal SH3 domain (SH3b), respectively, in their C-termini.	Proline	93-100	CD33 molecule	Homo sapiens	14-17
19129478-2	2009	p47(phox) and p67(phox) are linked via a high-affinity, tail-to-tail interaction involving a proline-rich region (PRR) and a C-terminal SH3 domain (SH3b), respectively, in their C-termini.	Proline	93-100	pleckstrin	Homo sapiens	18-22
19124609-4	2009	Both LSD1 knockdown and expression of Blimp-1 lacking the proline-rich domain derepressed the activities of Blimp-1-dependent luciferase reporters.	Proline	58-65	PR/SET domain 1	Homo sapiens	108-115
19158383-5	2009	In addition to the cysteine-rich domain, proline-117 is also essential for SNAP25 membrane binding, and experiments in HEK293 cells revealed that mutation of this residue inhibits membrane binding induced by coexpression with DHHC17, but not DHHC3 or DHHC7.	Proline	41-48	zinc finger DHHC-type palmitoyltransferase 17	Homo sapiens	226-232
19158383-5	2009	In addition to the cysteine-rich domain, proline-117 is also essential for SNAP25 membrane binding, and experiments in HEK293 cells revealed that mutation of this residue inhibits membrane binding induced by coexpression with DHHC17, but not DHHC3 or DHHC7.	Proline	41-48	zinc finger DHHC-type palmitoyltransferase 3	Homo sapiens	242-247
19158383-5	2009	In addition to the cysteine-rich domain, proline-117 is also essential for SNAP25 membrane binding, and experiments in HEK293 cells revealed that mutation of this residue inhibits membrane binding induced by coexpression with DHHC17, but not DHHC3 or DHHC7.	Proline	41-48	zinc finger DHHC-type palmitoyltransferase 7	Homo sapiens	251-256
19158383-7	2009	The role of proline-117 in SNAP25 palmitoylation is one of the first descriptions of elements within substrate proteins that modulate DHHC specificity.	Proline	12-19	synaptosome associated protein 25	Homo sapiens	27-33
19241372-3	2009	Dematin has two domains: a 315-residue, proline-rich "core" domain and a 68-residue carboxyl-terminal villin-type "headpiece" domain.	Proline	40-47	dematin actin binding protein	Homo sapiens	0-7
19241372-4	2009	Expression of full-length dematin in E. coli as a GST recombinant protein results in truncation within a proline, glutamic acid, serine, threonine rich region (PEST).	Proline	105-112	dematin actin binding protein	Homo sapiens	26-33
19157887-3	2009	Using a computational approach calculating the binding free energy of the complexes of the Dvl PDZ domain and each of the tripeptides VXV (X: any amino acid residue except Pro), we found that a tripeptide VWV had the highest binding affinity.	Proline	172-175	dishevelled segment polarity protein 1	Homo sapiens	91-94
19124461-8	2009	The proline-rich N-terminal portion of INSM1 is required for cyclin D1 binding.	Proline	4-11	INSM transcriptional repressor 1	Homo sapiens	39-44
19124461-8	2009	The proline-rich N-terminal portion of INSM1 is required for cyclin D1 binding.	Proline	4-11	cyclin D1	Homo sapiens	61-70
19124461-9	2009	Mutation of proline residues abolished cyclin D1 binding and also diminished its ability to induce cell cycle arrest.	Proline	12-19	cyclin D1	Homo sapiens	39-48
18996969-1	2009	AIMS: A domain peptide (DP) matching the Gly(2460)-Pro(2495) region of the cardiac type-2 ryanodine receptor (RyR2), DPc10, is known to mimic channel dysfunction associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), owing to its interference in a normal interaction of the N-terminal (1-600) and central (2000-2500) domains (viz.	Proline	51-54	ryanodine receptor 2	Canis lupus familiaris	110-114
19159658-5	2009	To study its physiological role in the central nervous system and evaluate its potential as a therapeutic target, we established cell lines that stably express recombinant hPROT and characterized its kinetic properties for proline uptake.	Proline	223-230	solute carrier family 6 member 7	Homo sapiens	172-177
19159658-6	2009	We then screened for inhibitors and identified a series of compounds that inhibit hPROT-mediated proline uptake.	Proline	97-104	solute carrier family 6 member 7	Homo sapiens	82-87
19146407-0	2009	Proline-directed phosphorylation of the dopamine transporter N-terminal domain.	Proline	0-7	solute carrier family 6 member 3	Rattus norvegicus	40-60
19140736-1	2009	Proline dehydrogenase (PRODH) catalyzes the oxidation of l-proline to Delta-1-pyrroline-5-carboxylate.	Proline	57-66	proline dehydrogenase 1	Homo sapiens	0-21
19146407-4	2009	We identified Thr53, present in a membrane proximal proline-directed kinase motif as the NDAT site phosphorylated in vitro by ERK1, JNK and p38, and confirmed by peptide mapping and mutagenesis that Thr53 is phosphorylated in vivo.	Proline	52-59	mitogen activated protein kinase 3	Rattus norvegicus	126-130
19140736-1	2009	Proline dehydrogenase (PRODH) catalyzes the oxidation of l-proline to Delta-1-pyrroline-5-carboxylate.	Proline	57-66	proline dehydrogenase 1	Homo sapiens	23-28
19146407-4	2009	We identified Thr53, present in a membrane proximal proline-directed kinase motif as the NDAT site phosphorylated in vitro by ERK1, JNK and p38, and confirmed by peptide mapping and mutagenesis that Thr53 is phosphorylated in vivo.	Proline	52-59	mitogen-activated protein kinase 8	Rattus norvegicus	132-135
19146407-4	2009	We identified Thr53, present in a membrane proximal proline-directed kinase motif as the NDAT site phosphorylated in vitro by ERK1, JNK and p38, and confirmed by peptide mapping and mutagenesis that Thr53 is phosphorylated in vivo.	Proline	52-59	mitogen activated protein kinase 14	Rattus norvegicus	140-143
19143629-2	2009	ALG-2 binds to its C-terminal proline-rich region that contains four tandem repeats of PXY (where X represents an uncharged amino acid).	Proline	30-37	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	0-5
19193875-2	2009	Removal of the tail domain and lysine-serine-proline (KSP) repeats of NF-M, but not neurofilament heavy, produced axons with impaired radial growth and reduced conduction velocities.	Proline	45-52	neurofilament, medium polypeptide	Mus musculus	70-74
19041431-2	2009	We previously reported that, via their SH3 domains, several members of the PCH proteins interact with the proline-rich region of Fas ligand (FasL, CD95L), a key death factor in immune cells.	Proline	106-113	Fas ligand	Homo sapiens	129-139
19041431-2	2009	We previously reported that, via their SH3 domains, several members of the PCH proteins interact with the proline-rich region of Fas ligand (FasL, CD95L), a key death factor in immune cells.	Proline	106-113	Fas ligand	Homo sapiens	141-145
19041431-2	2009	We previously reported that, via their SH3 domains, several members of the PCH proteins interact with the proline-rich region of Fas ligand (FasL, CD95L), a key death factor in immune cells.	Proline	106-113	Fas ligand	Homo sapiens	147-152
19274344-4	2009	The mutation leads to the substitution of leucine (L) by proline (P) at residue 76, an evolutionarily conserved position in Cx26 as well as in other connexins.	Proline	57-64	gap junction protein beta 2	Homo sapiens	124-128
19234535-3	2009	Hck interaction with WASp was found to be mediated by the Hck SH3 domain binding to the WASp proline-rich region, while Hck interaction with mDia1 was indirect but was required for binding to WASp.	Proline	93-100	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
19143627-2	2009	Specifically, the PTAP (Pro-Thr-Ala-Pro)-type primary L domain of HIV-1 recruits ESCRT-I by binding to Tsg101 (tumour susceptibility gene 101), and an auxiliary LYPX(n)L (Leu-Tyr-Pro-Xaa(n)-Leu)-type L domain recruits the ESCRT-III-binding partner Alix [ALG-2 (apoptosis-linked gene 2)-interacting protein X].	Proline	24-27	programmed cell death 6 interacting protein	Homo sapiens	248-252
19143627-2	2009	Specifically, the PTAP (Pro-Thr-Ala-Pro)-type primary L domain of HIV-1 recruits ESCRT-I by binding to Tsg101 (tumour susceptibility gene 101), and an auxiliary LYPX(n)L (Leu-Tyr-Pro-Xaa(n)-Leu)-type L domain recruits the ESCRT-III-binding partner Alix [ALG-2 (apoptosis-linked gene 2)-interacting protein X].	Proline	36-39	programmed cell death 6 interacting protein	Homo sapiens	248-252
19234535-3	2009	Hck interaction with WASp was found to be mediated by the Hck SH3 domain binding to the WASp proline-rich region, while Hck interaction with mDia1 was indirect but was required for binding to WASp.	Proline	93-100	WASP actin nucleation promoting factor	Homo sapiens	21-25
19234535-3	2009	Hck interaction with WASp was found to be mediated by the Hck SH3 domain binding to the WASp proline-rich region, while Hck interaction with mDia1 was indirect but was required for binding to WASp.	Proline	93-100	WASP actin nucleation promoting factor	Homo sapiens	26-29
19054125-4	2009	As a phenotypic suppressor of rsp5(A401E) cells, we isolated a quadruple variant (Thr357Ala/Glu401Gly/Lys764Glu/Glu767Gly) on a minimal medium containing the toxic proline analogue azetidine-2-carboxylate (AZC).	Proline	164-171	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	30-34
19038333-4	2009	Using a mass spectrometric approach, we found that PKD phosphorylates cortactin on Ser 298 in the 6th cortactin repeat region and on Ser 348, right before the helical-proline rich domain of cortactin.	Proline	167-174	protein kinase D1	Homo sapiens	51-54
19170759-7	2009	The consensus sequence for REV1-binding is denoted by x-x-x-F-F-y-y-y-y (x, no specific residue and y, no specific residue but not proline).	Proline	131-138	REV1 DNA directed polymerase	Homo sapiens	27-31
18769474-0	2009	Proline affects brain function in 22q11DS children with the low activity COMT 158 allele.	Proline	0-7	catechol-O-methyltransferase	Homo sapiens	73-77
19196429-4	2009	The substitution of helix 3 amino acid residues K204, V210, and E219 by proline inhibits the anti-Bax function of CyPrP.	Proline	72-79	BCL2 associated X, apoptosis regulator	Homo sapiens	98-101
19047365-4	2009	The HER4 Cyt1 isoform contains three proline-rich tyrosine (PY) WW binding motifs, while Cyt2 has only two.	Proline	37-44	erb-b2 receptor tyrosine kinase 4	Homo sapiens	4-8
19054325-2	2009	Here, we determined the functional importance of VirB10 domains denoted as the: (i) N-terminal cytoplasmic region, (ii) transmembrane (TM) alpha-helix, (iii) proline-rich region (PRR) and (iv) C-terminal beta-barrel domain.	Proline	158-165	type IV secretion system protein VirB10	Agrobacterium tumefaciens	49-55
19055526-3	2009	Hence, 11 variants of YscP(515) were generated by multiple Pro or Gly substitutions.	Proline	59-62	required for Yop secretion	Yersinia enterocolitica	22-26
19055526-5	2009	Taking the secondary motifs into account, Pro/Gly-variants were subjected to in silico modelling to simulate the extension of YscP upon needle growth.	Proline	42-45	required for Yop secretion	Yersinia enterocolitica	126-130
19052084-9	2009	Most importantly, we found that three proline-dependent phosphorylation sites at Ser123, Ser173, and Thr180, which cluster in a region between the DNA binding and IRF association domains of IRF3, contribute additively to the BGLF4-mediated repression of IRF3(5D) transactivation activity.	Proline	38-45	interferon regulatory factor 3	Homo sapiens	190-194
19052084-9	2009	Most importantly, we found that three proline-dependent phosphorylation sites at Ser123, Ser173, and Thr180, which cluster in a region between the DNA binding and IRF association domains of IRF3, contribute additively to the BGLF4-mediated repression of IRF3(5D) transactivation activity.	Proline	38-45	tegument serine/threonine protein kinase	Human gammaherpesvirus 4	225-230
19052084-9	2009	Most importantly, we found that three proline-dependent phosphorylation sites at Ser123, Ser173, and Thr180, which cluster in a region between the DNA binding and IRF association domains of IRF3, contribute additively to the BGLF4-mediated repression of IRF3(5D) transactivation activity.	Proline	38-45	interferon regulatory factor 3	Homo sapiens	254-258
18612811-0	2009	Myc-oncogene inactivating effect by proline rich polypeptide (PRP-1) in chondrosarcoma JJ012 cells.	Proline	36-43	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-3
18769474-4	2009	Associations of both COMT(158) genotype and elevated serum proline levels with abnormal brain function have been reported.	Proline	59-66	catechol-O-methyltransferase	Homo sapiens	21-25
18769474-7	2009	We hypothesized an interaction between the COMT(158) genotype and proline, predicting the strongest negative effect of high proline on brain function to occur in 22q11DS children who are carriers of the COMT(met) allele.	Proline	66-73	catechol-O-methyltransferase	Homo sapiens	43-47
18769474-7	2009	We hypothesized an interaction between the COMT(158) genotype and proline, predicting the strongest negative effect of high proline on brain function to occur in 22q11DS children who are carriers of the COMT(met) allele.	Proline	66-73	catechol-O-methyltransferase	Homo sapiens	203-207
18769474-7	2009	We hypothesized an interaction between the COMT(158) genotype and proline, predicting the strongest negative effect of high proline on brain function to occur in 22q11DS children who are carriers of the COMT(met) allele.	Proline	124-131	catechol-O-methyltransferase	Homo sapiens	43-47
18769474-7	2009	We hypothesized an interaction between the COMT(158) genotype and proline, predicting the strongest negative effect of high proline on brain function to occur in 22q11DS children who are carriers of the COMT(met) allele.	Proline	124-131	catechol-O-methyltransferase	Homo sapiens	203-207
18769474-9	2009	With regard to the SPEM performance, there was a significant interaction between the COMT(158) genotype and proline level with significantly decreased SPEM performance in children with high plasma proline levels and the low activity COMT(met) allele.	Proline	108-115	catechol-O-methyltransferase	Homo sapiens	85-89
18769474-9	2009	With regard to the SPEM performance, there was a significant interaction between the COMT(158) genotype and proline level with significantly decreased SPEM performance in children with high plasma proline levels and the low activity COMT(met) allele.	Proline	108-115	catechol-O-methyltransferase	Homo sapiens	233-237
18769474-9	2009	With regard to the SPEM performance, there was a significant interaction between the COMT(158) genotype and proline level with significantly decreased SPEM performance in children with high plasma proline levels and the low activity COMT(met) allele.	Proline	197-204	catechol-O-methyltransferase	Homo sapiens	85-89
18636508-7	2009	Fibril growth was a second-order process with an enthalpy of activation (27 +/- 5 kcal mol(-1)), which is indistinguishable from that of tetramer formation by cystatins, which involves limited conformational changes including proline trans to cis isomerization.	Proline	226-233	cystatin S	Homo sapiens	159-168
19083995-0	2009	The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence.	Proline	88-95	IQ motif and Sec7 domain ArfGEF 2	Homo sapiens	44-49
19192390-3	2009	The expression of BnP5CS1 and BnP5CS2 was induced, while the expression of BnPDH was inhibited under salt stress, ABA treatment and dehydration, prior to proline accumulation.	Proline	154-161	proline dehydrogenase 1, mitochondrial	Brassica napus	75-80
19192390-7	2009	During development, proline content was high in reproductive organs and was accompanied by markedly high expression of BnP5CS and BnPDH, suggesting possible roles of proline during flower development.	Proline	20-27	proline dehydrogenase 1, mitochondrial	Brassica napus	130-135
19083995-0	2009	The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence.	Proline	88-95	BAR/IMD domain containing adaptor protein 2	Homo sapiens	69-75
19083995-3	2009	The interaction was mediated by the binding of the C-terminal proline-rich sequence of IQ-ArfGEF/BRAG1 to the SH3 domain of IRSp53.	Proline	62-69	IQ motif and Sec7 domain ArfGEF 2	Homo sapiens	97-102
18835277-9	2009	Most interestingly, a proline substitution at the G63 position switches the Gme SMUG1 enzyme to an exclusive UDG as demonstrated by the uniform excision of uracil in both double-stranded and single-stranded DNA and the complete loss of XDG activity.	Proline	22-29	single-strand-selective monofunctional uracil-DNA glycosylase 1	Homo sapiens	80-85
19083995-3	2009	The interaction was mediated by the binding of the C-terminal proline-rich sequence of IQ-ArfGEF/BRAG1 to the SH3 domain of IRSp53.	Proline	62-69	BAR/IMD domain containing adaptor protein 2	Homo sapiens	124-130
18835277-9	2009	Most interestingly, a proline substitution at the G63 position switches the Gme SMUG1 enzyme to an exclusive UDG as demonstrated by the uniform excision of uracil in both double-stranded and single-stranded DNA and the complete loss of XDG activity.	Proline	22-29	uracil DNA glycosylase	Homo sapiens	109-112
19028693-9	2009	The most likely hypotheses to explain the incompatibility of human profilin-I with Cdc12p are differences in interactions with the proline-rich sequences in the FH1 domain of Cdc12p and wider "wings" that interact with actin.	Proline	131-138	profilin 1	Homo sapiens	67-77
19000035-5	2009	A motif-like sequence Val(480)-Pro(481)-Pro(482) was identified in the C-terminus of b(0,+)AT to be responsible for the C-terminus action in promoting the trafficking of rBAT-b(0,+)AT heterodimeric complex from the ER (endoplasmic reticulum) to Golgi apparatus.	Proline	31-34	solute carrier family 7 member 9	Homo sapiens	85-93
19049962-1	2009	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase.	Proline	38-45	cyclin-dependent kinase 5	Mus musculus	0-25
19049962-1	2009	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase.	Proline	38-45	cyclin-dependent kinase 5	Mus musculus	27-31
18996842-4	2009	Substitution of presenilin-1 residues Pro-374 and Glu-376 by site-directed mutagenesis greatly reduces the ability of PS1 to associate with TRAF6.	Proline	38-41	presenilin 1	Homo sapiens	16-28
18996842-4	2009	Substitution of presenilin-1 residues Pro-374 and Glu-376 by site-directed mutagenesis greatly reduces the ability of PS1 to associate with TRAF6.	Proline	38-41	presenilin 1	Homo sapiens	118-121
18996842-4	2009	Substitution of presenilin-1 residues Pro-374 and Glu-376 by site-directed mutagenesis greatly reduces the ability of PS1 to associate with TRAF6.	Proline	38-41	TNF receptor associated factor 6	Homo sapiens	140-145
19015262-4	2009	However, in contrast with this view, Sit4-dependent Gln3 dephosphorylation is greater in Gln than Pro.	Proline	98-101	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	52-56
19000035-5	2009	A motif-like sequence Val(480)-Pro(481)-Pro(482) was identified in the C-terminus of b(0,+)AT to be responsible for the C-terminus action in promoting the trafficking of rBAT-b(0,+)AT heterodimeric complex from the ER (endoplasmic reticulum) to Golgi apparatus.	Proline	31-34	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	170-174
19000035-5	2009	A motif-like sequence Val(480)-Pro(481)-Pro(482) was identified in the C-terminus of b(0,+)AT to be responsible for the C-terminus action in promoting the trafficking of rBAT-b(0,+)AT heterodimeric complex from the ER (endoplasmic reticulum) to Golgi apparatus.	Proline	31-34	solute carrier family 7 member 9	Homo sapiens	175-183
19000035-5	2009	A motif-like sequence Val(480)-Pro(481)-Pro(482) was identified in the C-terminus of b(0,+)AT to be responsible for the C-terminus action in promoting the trafficking of rBAT-b(0,+)AT heterodimeric complex from the ER (endoplasmic reticulum) to Golgi apparatus.	Proline	40-43	solute carrier family 7 member 9	Homo sapiens	85-93
19000035-5	2009	A motif-like sequence Val(480)-Pro(481)-Pro(482) was identified in the C-terminus of b(0,+)AT to be responsible for the C-terminus action in promoting the trafficking of rBAT-b(0,+)AT heterodimeric complex from the ER (endoplasmic reticulum) to Golgi apparatus.	Proline	40-43	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	170-174
19000035-5	2009	A motif-like sequence Val(480)-Pro(481)-Pro(482) was identified in the C-terminus of b(0,+)AT to be responsible for the C-terminus action in promoting the trafficking of rBAT-b(0,+)AT heterodimeric complex from the ER (endoplasmic reticulum) to Golgi apparatus.	Proline	40-43	solute carrier family 7 member 9	Homo sapiens	175-183
19004829-8	2009	Expression of the DOCK5 COOH-terminal region (Met1738-Gln1870), containing potential Src homology 3 domain-binding proline-rich sites but lacking other functional regions, inhibited Caco-2 spreading and coimmunoprecipitated with CrkL.	Proline	115-122	dedicator of cytokinesis 5	Homo sapiens	18-23
19090677-9	2009	Crystallographic analysis reveals the formation of a stable, novel covalent bond for PMSF between the catalytic nitrogen of the N-terminal proline and the sulfur of PMSF with complete, well-defined electron density in all three active sites of the MIF homotrimer.	Proline	139-146	macrophage migration inhibitory factor	Homo sapiens	248-251
19057509-3	2009	The Med7N/31 submodule shows a conserved novel fold, with two proline-rich stretches in Med7N wrapping around the right-handed four-helix bundle of Med31.	Proline	62-69	mediator complex subunit 7	Homo sapiens	4-9
19057509-3	2009	The Med7N/31 submodule shows a conserved novel fold, with two proline-rich stretches in Med7N wrapping around the right-handed four-helix bundle of Med31.	Proline	62-69	mediator complex subunit 7	Homo sapiens	88-93
19057509-3	2009	The Med7N/31 submodule shows a conserved novel fold, with two proline-rich stretches in Med7N wrapping around the right-handed four-helix bundle of Med31.	Proline	62-69	mediator complex subunit 31	Homo sapiens	148-153
19144837-3	2009	The GAERS Ca(v)3.2 mutation (gcm) produces an arginine to proline (R1584P) substitution in exon 24 of Cacna1h, encoding a portion of the III-IV linker region in Ca(v)3.2. gcm segregates codominantly with the number of seizures and time in seizure activity in progeny of an F1 intercross.	Proline	58-65	calcium voltage-gated channel subunit alpha1 H	Rattus norvegicus	102-109
19167313-1	2009	In the crystal structure of the complex between the soluble extracellular domain of tissue factor (sTF) and active-site-inhibited VIIa, residues 91 and 92 in the Pro(79)-Pro(92) loop of sTF interact with the catalytic domain of VIIa.	Proline	162-165	coagulation factor III, tissue factor	Homo sapiens	84-97
19199308-0	2009	The proline-catalyzed double Mannich reaction of acetaldehyde with N-Boc imines.	Proline	4-11	BOC cell adhesion associated, oncogene regulated	Homo sapiens	69-72
19199308-1	2009	Double-cross: Proline catalyzes the double Mannich reaction of acetaldehyde with N-Boc imines in excellent yields (up to 99 %; Boc = tert-butoxycarbonyl) and close to perfect diastereo- and enantioselectivities.	Proline	14-21	BOC cell adhesion associated, oncogene regulated	Homo sapiens	83-86
19199308-1	2009	Double-cross: Proline catalyzes the double Mannich reaction of acetaldehyde with N-Boc imines in excellent yields (up to 99 %; Boc = tert-butoxycarbonyl) and close to perfect diastereo- and enantioselectivities.	Proline	14-21	BOC cell adhesion associated, oncogene regulated	Homo sapiens	127-130
18713067-1	2009	The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a transcription factor that functions as an important regulator of vertebrate development and many other processes in the adult including haematopoiesis.	Proline	9-16	hematopoietically expressed homeobox	Homo sapiens	50-53
18713067-1	2009	The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a transcription factor that functions as an important regulator of vertebrate development and many other processes in the adult including haematopoiesis.	Proline	9-16	hematopoietically expressed homeobox	Homo sapiens	84-92
19400285-0	2009	Analogues of arginine vasopressin modified at position 2 with proline derivatives: selective antagonists of oxytocin in vitro.	Proline	62-69	arginine vasopressin	Homo sapiens	22-33
19400285-0	2009	Analogues of arginine vasopressin modified at position 2 with proline derivatives: selective antagonists of oxytocin in vitro.	Proline	62-69	oxytocin/neurophysin I prepropeptide	Homo sapiens	108-116
19167313-1	2009	In the crystal structure of the complex between the soluble extracellular domain of tissue factor (sTF) and active-site-inhibited VIIa, residues 91 and 92 in the Pro(79)-Pro(92) loop of sTF interact with the catalytic domain of VIIa.	Proline	170-173	coagulation factor III, tissue factor	Homo sapiens	84-97
18701806-2	2009	Proline is the most abundant residue in amelogenin and is located upstream to all MMP-20 cleavage sites in the amelogenin sequence.	Proline	0-7	matrix metallopeptidase 20	Homo sapiens	82-88
18701806-4	2009	This study sought to elucidate the effect of the C-terminal prolines on apatite binding and MMP-20 hydrolysis.	Proline	60-68	matrix metallopeptidase 20	Homo sapiens	92-98
18728356-7	2009	RUNX2 is regulated via phosphorylation of critical serine residues in the proline/serine/threonine domain.	Proline	74-81	RUNX family transcription factor 2	Homo sapiens	0-5
18787108-6	2009	CTRP9 is a secreted glycoprotein with multiple post-translational modifications in its collagen domain that include hydroxylated prolines and hydroxylated and glycosylated lysines.	Proline	129-137	C1q and tumor necrosis factor related protein 9	Mus musculus	0-5
19747127-0	2009	The antibacterial effect of a proline-rich antibacterial peptide A3-APO.	Proline	30-37	aminopeptidase O (putative)	Homo sapiens	68-71
19747127-5	2009	The proline-rich peptide A3-APO represents a family of a new class of synthetic dimers that kill bacteria by a dual mode of action and carry domains for interaction with both the bacterial membrane and an intracellular target.	Proline	4-11	aminopeptidase O (putative)	Homo sapiens	28-31
19747127-7	2009	As many other proline-rich peptides, A3-APO binds to the C-terminal helical lid of bacterial DnaK and inhibits chaperone-assisted protein folding in bacteria but not in mammalian Hsp70.	Proline	14-21	aminopeptidase O (putative)	Homo sapiens	40-43
18701883-6	2009	Conserved glycine/proline residues are central to the "beta-trefoil fold" characteristic of the secondary structure of FGF family proteins and substitution of these residues is likely to disrupt structure and consequently function.	Proline	18-25	fibroblast growth factor 3	Homo sapiens	119-122
19545486-2	2009	Just a small number of proline-specific hydrolases including dipeptidyl peptidase IV (DPP-IV) and related molecules is capable of cleaving such post-prolyl bond.	Proline	23-30	dipeptidyl peptidase 4	Homo sapiens	61-84
19545486-2	2009	Just a small number of proline-specific hydrolases including dipeptidyl peptidase IV (DPP-IV) and related molecules is capable of cleaving such post-prolyl bond.	Proline	23-30	dipeptidyl peptidase 4	Homo sapiens	86-92
19291875-2	2009	The p53 codon 72 Arg-Pro (CGC to CCC) polymorphism of exon 4 affects various biological properties; recently, it was reported that this polymorphism affects the ability to induce apoptosis in vitro.	Proline	21-24	tumor protein p53	Homo sapiens	4-7
19273103-8	2009	EVH1 domains also recognize non-proline motifs, as illustrated by the structure of an EVH1:LIM3 complex and the extended EVH1 ligands of the verprolin family.	Proline	32-39	LIM homeobox 3	Homo sapiens	91-95
19288447-2	2009	The enzyme prolidase plays an important role in the breakdown of collagen and the breakdown of intracellular protein especially in the final stage when peptides and dipeptides contain a high level of proline.	Proline	200-207	peptidase D	Homo sapiens	11-20
19018480-6	2009	The central proline-rich region of WASP serves as docking site to several adaptor proteins.	Proline	12-19	WASP actin nucleation promoting factor	Homo sapiens	35-39
20093729-1	2009	The N-terminal regions of annexins A7 (synexin) and A11 consist of an extended series of short sequence repeats rich in tyrosine, proline, and glycine that provide binding sites for other proteins that may be recruited to membranes by the annexins and that may modulate the calcium and membrane binding activities of the annexin core domains.	Proline	130-137	annexin A7	Homo sapiens	39-46
19734262-1	2009	The potential of metchnikowin, a 26-amino acid residue proline-rich antimicrobial peptide synthesized in the fat body of Drosophila melanogaster was explored to engineer disease resistance in barley against devastating fungal plant pathogens.	Proline	55-62	Metchnikowin	Drosophila melanogaster	17-29
19151537-3	2009	The expression of HIF alpha-chains is post-translationally regulated and hydroxylation at one or two of the conserved proline residues by prolyl-hydroxylase domains (PHDs) is a critical step for the oxygen-dependent recruitment of the von Hippel-Lindau gene product (pVHL), a recognition component of the E3 ubiquitin ligase complex, and degradation of HIF-alpha.	Proline	118-125	von Hippel-Lindau tumor suppressor	Homo sapiens	267-271
19347242-2	2009	Tyrosine phosphorylated Glu-Pro-Ile-Tyr-Ala motif in CagA (CagA-P) plays a critical role in the morphological transformation of cells.	Proline	28-31	S100 calcium binding protein A8	Homo sapiens	53-57
19347242-2	2009	Tyrosine phosphorylated Glu-Pro-Ile-Tyr-Ala motif in CagA (CagA-P) plays a critical role in the morphological transformation of cells.	Proline	28-31	S100 calcium binding protein A8	Homo sapiens	59-65
19344079-5	2009	We report here a Thai family with Liddle"s syndrome caused by a novel P615H missense mutation in the proline-rich domain of the SCNN1B gene coding for the beta-subunit of ENaC.	Proline	101-108	sodium channel epithelial 1 subunit beta	Homo sapiens	128-134
19013523-5	2009	Increasing the expression of TG2 led to increased extracellular TG2 activity (p&lt;0.05), elevated epsilon(gamma-glutamyl) lysine crosslinking in the ECM and higher levels of ECM collagen per cell by (3)H-proline labelling.	Proline	205-212	transglutaminase 2, C polypeptide	Mus musculus	29-32
19347309-4	2009	In the second case, after exposure to cytokines such as IL-4, IL-10, or IL-13, macrophages produce polyamines and proline, which induce proliferation and collagen production, respectively.	Proline	114-121	interleukin 4	Homo sapiens	56-60
19347309-4	2009	In the second case, after exposure to cytokines such as IL-4, IL-10, or IL-13, macrophages produce polyamines and proline, which induce proliferation and collagen production, respectively.	Proline	114-121	interleukin 10	Homo sapiens	62-67
19347309-4	2009	In the second case, after exposure to cytokines such as IL-4, IL-10, or IL-13, macrophages produce polyamines and proline, which induce proliferation and collagen production, respectively.	Proline	114-121	interleukin 13	Homo sapiens	72-77
19079329-4	2009	(1, 2) These T cells are specific for proline- and glutamine-rich gluten peptides that are resistant to proteolysis and that have been become deamidated by the enzyme transglutaminase 2 (TG2).	Proline	38-45	transglutaminase 2	Homo sapiens	167-185
19218100-3	2009	RESULTS: 3H-ouabain and synthetic HES1 derivative showed some binding activity with the equilibrium dissociation constant (KD) of 24.58 nmol/L, with the the receptor density of 492.43 fmol x mg(-1) pro.	Proline	198-201	hes family bHLH transcription factor 1	Homo sapiens	34-38
19011639-2	2009	Mass spectrometry-based global peptide profiling of mice lacking dipeptidyl peptidase 4 (DPP4) identified endogenous DPP4 substrates and revealed an unrecognized pathway during proline peptide catabolism that interlinks aminopeptidase and DPP4 activities.	Proline	177-184	dipeptidylpeptidase 4	Mus musculus	65-87
19011639-2	2009	Mass spectrometry-based global peptide profiling of mice lacking dipeptidyl peptidase 4 (DPP4) identified endogenous DPP4 substrates and revealed an unrecognized pathway during proline peptide catabolism that interlinks aminopeptidase and DPP4 activities.	Proline	177-184	dipeptidylpeptidase 4	Mus musculus	89-93
19079329-4	2009	(1, 2) These T cells are specific for proline- and glutamine-rich gluten peptides that are resistant to proteolysis and that have been become deamidated by the enzyme transglutaminase 2 (TG2).	Proline	38-45	transglutaminase 2	Homo sapiens	187-190
18951902-6	2008	A molecule of l-proline was observed near the FAD, and this ligand superimposed well with isatin, a reversible inhibitor of MAO-B, when the structures of MAO-N proline and MAO-B-isatin were overlaid.	Proline	14-23	monoamine oxidase B	Homo sapiens	124-129
19098908-5	2009	These phenotypes are lost in cells expressing MACC1 mutants lacking the SH3 domain or the proline-rich motif.	Proline	90-97	metastasis associated in colon cancer 1	Mus musculus	46-51
19645738-7	2009	Ab initio analysis of the AtCesA3 subdomain flanking the conserved proline residue predicted that the amino acid substitution to serine alters protein secondary structure in the catalytic domain.	Proline	67-74	Cellulose synthase family protein	Arabidopsis thaliana	26-33
19940524-1	2009	OBJECTIVES: Several studies have examined the association of codon 72 polymorphism of the TP53 gene, encoding either arginine or proline, in several tumor types but none have investigated its role in Kaposi"s sarcoma (KS) development.	Proline	129-136	tumor protein p53	Homo sapiens	90-94
19430534-4	2009	The mutated transcript encodes a novel protein in which the sixty-eighth amino acid, Alanine, is substituted by Proline (IRF-5P68) in the DNA binding domain of IRF-5.	Proline	112-119	interferon regulatory factor 5	Homo sapiens	121-126
19048289-1	2009	Proline-, glutamic acid-, and leukine-rich protein (PELP1) is a novel co-regulatory protein that modulates genomic and non genomic actions of estrogen receptors.	Proline	0-7	proline, glutamate and leucine rich protein 1	Homo sapiens	52-57
18951902-6	2008	A molecule of l-proline was observed near the FAD, and this ligand superimposed well with isatin, a reversible inhibitor of MAO-B, when the structures of MAO-N proline and MAO-B-isatin were overlaid.	Proline	14-23	monoamine oxidase B	Homo sapiens	172-177
19053766-4	2008	Ac-Trp-[Arg(24),Lys(25),Asp(31),Pro(34),Phe(35)]CGRP(8-37)-NH(2), 5 (K(i) = 0.06 nM) had the highest CGRP(1) receptor affinity.	Proline	32-35	calcitonin related polypeptide alpha	Homo sapiens	48-52
18977201-3	2008	The C-terminal cytoplasmic (C-ter) domain of GPR54 contains a segment rich in proline and arginine residues that corresponds to the primary structure of four overlapping SH3 binding motifs.	Proline	78-85	KISS1 receptor	Homo sapiens	45-50
19074869-3	2008	We report a functional germline mutation (polymorphism) in the galectin-3 gene at position 191 (rs4644) substituting proline with histidine (P64H), which results in susceptibility to matrix metalloproteinase cleavage and acquisition of resistance to drug-induced apoptosis.	Proline	117-124	galectin 3	Homo sapiens	63-73
18972488-0	2008	Conformational dynamics of minimal elastin-like polypeptides: the role of proline revealed by molecular dynamics and nuclear magnetic resonance.	Proline	74-81	elastin	Homo sapiens	35-42
18972488-4	2008	Moreover, in the previous simulations, the proline residue in the ELP is found to act as a hinge, thereby allowing for the large-amplitude opening and closing conformational motion of the ITT.	Proline	43-50	nuclear receptor subfamily 5 group A member 1	Homo sapiens	66-69
18972488-6	2008	The results show that the site-directed mutation completely alters the properties of this ELP, thus confirming the importance of the highly conserved proline residue in the ITT.	Proline	150-157	nuclear receptor subfamily 5 group A member 1	Homo sapiens	90-93
19006380-5	2008	A 4-fold enhancement of the inhibitor activity upon replacement of the 4-CH2 group of the proline ring by CF2 is a consequence of a weak hydrogen bond formed between the fluorine atom and the hydroxy group of Tyr473 of the host enzyme.	Proline	90-97	ATPase H+ transporting accessory protein 1	Homo sapiens	106-109
18794809-1	2008	Proline oxidase (POX), a flavoenzyme localized at the inner mitochondrial membrane, catalyzes the first step of proline degradation by converting proline to pyrroline-5-carboxylate (P5C).	Proline	112-119	proline dehydrogenase 1	Homo sapiens	0-15
18794809-1	2008	Proline oxidase (POX), a flavoenzyme localized at the inner mitochondrial membrane, catalyzes the first step of proline degradation by converting proline to pyrroline-5-carboxylate (P5C).	Proline	112-119	proline dehydrogenase 1	Homo sapiens	17-20
18818200-7	2008	An enhanced response to the knob "B" mimetic peptides Gly-His-Arg-Pro(am) and Ala-His-Arg-Pro(am) suggests that incorporation of nitrated fibrinogen molecules accelerates fibrin lateral aggregation.	Proline	66-69	fibrinogen beta chain	Homo sapiens	138-148
18794809-1	2008	Proline oxidase (POX), a flavoenzyme localized at the inner mitochondrial membrane, catalyzes the first step of proline degradation by converting proline to pyrroline-5-carboxylate (P5C).	Proline	146-153	proline dehydrogenase 1	Homo sapiens	0-15
18794809-1	2008	Proline oxidase (POX), a flavoenzyme localized at the inner mitochondrial membrane, catalyzes the first step of proline degradation by converting proline to pyrroline-5-carboxylate (P5C).	Proline	146-153	proline dehydrogenase 1	Homo sapiens	17-20
18794809-1	2008	Proline oxidase (POX), a flavoenzyme localized at the inner mitochondrial membrane, catalyzes the first step of proline degradation by converting proline to pyrroline-5-carboxylate (P5C).	Proline	112-119	pyrroline-5-carboxylate reductase 1	Homo sapiens	182-185
18794809-2	2008	POX is markedly elevated during p53-induced apoptosis and generates proline-dependent reactive oxygen species (ROS), specifically superoxide radicals, to induce apoptosis through both mitochondrial and death receptor pathways.	Proline	68-75	proline dehydrogenase 1	Homo sapiens	0-3
18986166-5	2008	IDE specifically degrades bradykinin and kallidin at the Pro/Phe site.	Proline	57-60	insulin degrading enzyme	Homo sapiens	0-3
18794809-11	2008	Thus, POX metabolism of substrate proline affects multiple signaling pathways, modulating both apoptosis and tumor growth, and could be an attractive target to metabolically control the cancer phenotypes.	Proline	34-41	proline dehydrogenase 1	Homo sapiens	6-9
18823992-1	2008	PR39, a naturally occurring and cell-permeable proline- and arginine-rich peptide, blocks the degradation of inhibitor of nuclear factor kappaB (IkappaBalpha), thereby attenuating inflammation.	Proline	47-54	NFKB inhibitor alpha	Homo sapiens	145-157
18986166-5	2008	IDE specifically degrades bradykinin and kallidin at the Pro/Phe site.	Proline	57-60	kininogen 1	Homo sapiens	26-36
19029042-6	2008	We assessed two candidates for the betaine/proline transporter: SIT1 (IMINO; encoded by Slc6a20a) and PROT (Slc6a7).	Proline	43-50	suppression inducing transmembrane adaptor 1	Mus musculus	64-68
19092326-7	2008	A genetic-based study revealed heterozygosis of the beta-globin gene for a A>C (Thr>Pro) substitution at position 87 called Hemoglobin Valletta (alpha 2 beta 2 87 PRO) with a C>G transition in homozygosis in beta-globin intronic polymorphism intervening sequence 2 at nucleotide 745.	Proline	84-87	hemoglobin subunit beta	Homo sapiens	52-63
18991400-9	2008	Alanine mutations of Lys(484), Leu(552), Asp(591), Ile(602), Lys(616), Asp(620), and Pro(621) compromised affinities for insulin 2-5-fold.	Proline	85-88	insulin	Homo sapiens	121-128
18790850-4	2008	In general, the CPAIMD (B-LYP) simulations predict a simplified structural model of proline/water mixtures consisting of fewer distinct local motifs.	Proline	84-91	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	26-29
19018773-9	2008	Overexpression of CHOP in AsPC-1 cells increased radiation sensitivity by IGF-II simulation under hypoxic conditions, whereas suppression of CHOP expression levels with small hairpin RNA or a dominant negative form of a proline-rich extensin-like receptor protein kinase in hypoxia decreased IGF-induced radiosensitivity.	Proline	220-227	DNA damage inducible transcript 3	Homo sapiens	141-145
19029042-6	2008	We assessed two candidates for the betaine/proline transporter: SIT1 (IMINO; encoded by Slc6a20a) and PROT (Slc6a7).	Proline	43-50	solute carrier family 6 (neurotransmitter transporter), member 20A	Mus musculus	88-96
19029042-6	2008	We assessed two candidates for the betaine/proline transporter: SIT1 (IMINO; encoded by Slc6a20a) and PROT (Slc6a7).	Proline	43-50	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	Mus musculus	108-114
19029042-9	2008	By contrast, exogenously expressed mouse SIT1 transported both betaine and proline and closely resembled the embryonic transporter.	Proline	75-82	suppression inducing transmembrane adaptor 1	Mus musculus	41-45
18799583-7	2008	Nef-induced PD-1 upregulation requires its proline-rich motif and the activation of the downstream kinase p38.	Proline	43-50	S100 calcium binding protein B	Homo sapiens	0-3
18821729-12	2008	In conclusion, the replacement of Pro by beta-Pro may be useful for fine-tuning CLA immunosuppressive potency and undesirable toxicity.	Proline	34-37	clasper	Mus musculus	80-83
18940788-0	2008	The proline-dependent transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces cerevisiae.	Proline	4-11	Put3p	Saccharomyces cerevisiae S288C	43-47
18940788-0	2008	The proline-dependent transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces cerevisiae.	Proline	4-11	Mch5p	Saccharomyces cerevisiae S288C	103-107
18940788-4	2008	Frequently, this overexpression is mediated by the transcription factor Put3, which also regulates the proline catabolic genes PUT1 and PUT2.	Proline	103-110	Put3p	Saccharomyces cerevisiae S288C	72-76
18940788-4	2008	Frequently, this overexpression is mediated by the transcription factor Put3, which also regulates the proline catabolic genes PUT1 and PUT2.	Proline	103-110	proline dehydrogenase	Saccharomyces cerevisiae S288C	127-131
18940788-4	2008	Frequently, this overexpression is mediated by the transcription factor Put3, which also regulates the proline catabolic genes PUT1 and PUT2.	Proline	103-110	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	136-140
18940788-8	2008	Put3-mediated transcriptional activation requires proline as an inducer.	Proline	50-57	Put3p	Saccharomyces cerevisiae S288C	0-4
18940788-9	2008	We find that the increased activity of Put3 in one of the suppressor mutants is caused by increased intracellular levels of proline.	Proline	124-131	Put3p	Saccharomyces cerevisiae S288C	39-43
23675098-3	2008	The TP53 codon 72 polymorphism is a single-nucleotide polymorphism (SNP) in exon 4, resulting in the expression of either arginine (CGC) or proline (CCC) residues.	Proline	140-147	tumor protein p53	Homo sapiens	4-8
19104705-5	2008	One common polymorphism in PPAR-gamma gene is proline to alanine substitution (Pro12Ala) which results from a CCA to GCA missense substitution in codon 12 of exon 2 of the PPAR-gamma gene.	Proline	46-53	peroxisome proliferator activated receptor gamma	Homo sapiens	27-37
19104705-5	2008	One common polymorphism in PPAR-gamma gene is proline to alanine substitution (Pro12Ala) which results from a CCA to GCA missense substitution in codon 12 of exon 2 of the PPAR-gamma gene.	Proline	46-53	peroxisome proliferator activated receptor gamma	Homo sapiens	172-182
18799583-7	2008	Nef-induced PD-1 upregulation requires its proline-rich motif and the activation of the downstream kinase p38.	Proline	43-50	programmed cell death 1	Homo sapiens	12-16
19017801-6	2008	Furthermore, we functionally characterized 10 missense mutations within the SLC26A4 ORF, and consistently found that on the protein level, an addition or omission of a proline or a charged amino acid in the SLC26A4 sequence is detrimental to its function.	Proline	168-175	solute carrier family 26 member 4	Homo sapiens	76-83
18768736-0	2008	The orphan transporter Rxt1/NTT4 (SLC6A17) functions as a synaptic vesicle amino acid transporter selective for proline, glycine, leucine, and alanine.	Proline	112-119	solute carrier family 6 member 17	Rattus norvegicus	28-32
18768736-0	2008	The orphan transporter Rxt1/NTT4 (SLC6A17) functions as a synaptic vesicle amino acid transporter selective for proline, glycine, leucine, and alanine.	Proline	112-119	solute carrier family 6 member 17	Rattus norvegicus	34-41
18768736-3	2008	Here, we provide evidence indicating that Rxt1/NTT4 functions as a vesicular transporter selective for proline, glycine, leucine, and alanine.	Proline	103-110	solute carrier family 6 member 17	Rattus norvegicus	47-51
18768736-5	2008	Small interfering RNA (siRNA)-mediated knockdown of Rxt1/NTT4 in PC12 cells resulted in selective reductions in uptake levels for proline, glycine, leucine, and alanine.	Proline	130-137	solute carrier family 6 member 17	Rattus norvegicus	57-61
18768736-8	2008	Finally, proline uptake in both PC12 cells and Rxt1/NTT4-transfected CHO cells was dependent on the electrochemical gradient maintained by the vacuolar-type H(+)-ATPase.	Proline	9-16	solute carrier family 6 member 17	Rattus norvegicus	52-56
18768736-9	2008	These data indicate that the orphan Rxt1/NTT4 protein functions as a vesicular transporter for proline, glycine, leucine, and alanine, further suggesting its important role in synaptic transmission.	Proline	95-102	solute carrier family 6 member 17	Rattus norvegicus	41-45
19122374-1	2008	Sh2b3/Lnk consisting of an N-terminal proline-rich region, PH-, SH2-domains and a tyrosine phosphorylation site, forms an intracellular adaptor protein family conserved from drosophila to mammals, together with Sh2b1/SH2-B and Sh2b2/APS (adaptor protein with PH and SH2 domains).	Proline	38-45	Lnk	Drosophila melanogaster	6-9
19137883-9	2008	RESULTS: The genetic genotype of p53 gene codon 72 in keloids included Arg/Arg in 7 cases, Pro/Arg in 21 cases, Pro/ Pro in 7 cases.	Proline	91-94	tumor protein p53	Homo sapiens	33-36
19137883-9	2008	RESULTS: The genetic genotype of p53 gene codon 72 in keloids included Arg/Arg in 7 cases, Pro/Arg in 21 cases, Pro/ Pro in 7 cases.	Proline	112-115	tumor protein p53	Homo sapiens	33-36
19137883-9	2008	RESULTS: The genetic genotype of p53 gene codon 72 in keloids included Arg/Arg in 7 cases, Pro/Arg in 21 cases, Pro/ Pro in 7 cases.	Proline	112-115	tumor protein p53	Homo sapiens	33-36
19037317-4	2008	Gluten lacks such peptides, but tissue transglutaminase (TG2) introduces negatively charged residues at defined positions into gluten T-cell epitopes by deamidating specific glutamine residues on the basis of their spacing to proline residues.	Proline	226-233	transglutaminase 2	Homo sapiens	32-55
19030774-11	2008	Analysis of the PRNP gene showed a proline/leucine substitution at codon 102 in all three patients, associated with methionine/valine heterozygosity at the polymorphic codon 129.	Proline	35-42	prion protein	Homo sapiens	16-20
18980262-7	2008	Some phosphorylation sites are contained in motifs that closely resemble those in mammalian S6K (serines followed by a tyrosine or a phenylalanine) and 4E-BP1 (serines followed by a proline).	Proline	182-189	nuclear factor kappa B subunit 1	Homo sapiens	153-158
18983130-1	2008	The structure of proline in [proline + K]+ has been investigated in the gas phase using high level DFT and MP2 calculations and infrared photo dissociation spectroscopy with a free electron laser (FELIX).	Proline	17-24	tryptase pseudogene 1	Homo sapiens	107-110
18782764-4	2008	Chimeras consisting of the dimerization domain and the alpha-helical linker of the bacterial proline cis/trans isomerase FkpA and the periplasmic oxidase DsbA gave rise to enzymes that catalyzed the folding of multidisulfide substrate proteins in vivo with comparable efficiency to E. coli DsbC.	Proline	93-100	putative protein DsbC	Escherichia coli	290-294
19004782-7	2008	This variant, TRPM2(P1018L), produces a missense change in the channel protein whereby proline 1018 (Pro(1018)) is replaced by leucine (Leu(1018)).	Proline	87-94	transient receptor potential cation channel subfamily M member 2	Homo sapiens	14-19
19004782-7	2008	This variant, TRPM2(P1018L), produces a missense change in the channel protein whereby proline 1018 (Pro(1018)) is replaced by leucine (Leu(1018)).	Proline	101-104	transient receptor potential cation channel subfamily M member 2	Homo sapiens	14-19
18725412-0	2008	Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation.	Proline	0-7	PHD finger protein 1	Homo sapiens	51-55
18725412-0	2008	Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation.	Proline	0-7	microtubule associated protein tau	Homo sapiens	114-117
18725412-16	2008	The data provide a framework for the global folding of Tau dependent on proline-directed phosphorylation in the domains flanking the repeats and the consequences for pathological properties of Tau.	Proline	72-79	microtubule associated protein tau	Homo sapiens	55-58
18725412-16	2008	The data provide a framework for the global folding of Tau dependent on proline-directed phosphorylation in the domains flanking the repeats and the consequences for pathological properties of Tau.	Proline	72-79	microtubule associated protein tau	Homo sapiens	193-196
18789888-2	2008	Here, we show that Grb2, an SH3 domain-containing adaptor protein, binds to the proline-rich domain of FasL and regulates its cell surface expression.	Proline	80-87	growth factor receptor bound protein 2	Homo sapiens	19-23
18789888-2	2008	Here, we show that Grb2, an SH3 domain-containing adaptor protein, binds to the proline-rich domain of FasL and regulates its cell surface expression.	Proline	80-87	Fas ligand	Homo sapiens	103-107
18802692-6	2008	Based on the fact that proline has stress-protective activity, S. cerevisiae cells that accumulate proline were constructed by disrupting the PUT1 gene involved in the degradation pathway and by expressing the mutant PRO1 gene encoding the feedback inhibition-less sensitive gamma-glutamate kinase to enhance the biosynthetic activity.	Proline	23-30	proline dehydrogenase	Saccharomyces cerevisiae S288C	142-146
18506409-1	2008	Proline metabolism in mammals involves two other amino acids, glutamate and ornithine, and five enzymatic activities, Delta(1)-pyrroline-5-carboxylate (P5C) reductase (P5CR), proline oxidase, P5C dehydrogenase, P5C synthase and ornithine-delta-aminotransferase (OAT).	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	168-172
18506409-1	2008	Proline metabolism in mammals involves two other amino acids, glutamate and ornithine, and five enzymatic activities, Delta(1)-pyrroline-5-carboxylate (P5C) reductase (P5CR), proline oxidase, P5C dehydrogenase, P5C synthase and ornithine-delta-aminotransferase (OAT).	Proline	0-7	aldehyde dehydrogenase 4 family member A1	Homo sapiens	192-209
18506409-1	2008	Proline metabolism in mammals involves two other amino acids, glutamate and ornithine, and five enzymatic activities, Delta(1)-pyrroline-5-carboxylate (P5C) reductase (P5CR), proline oxidase, P5C dehydrogenase, P5C synthase and ornithine-delta-aminotransferase (OAT).	Proline	0-7	ornithine aminotransferase	Homo sapiens	228-260
18528746-2	2008	Multiple studies in humans and in mouse and fly models suggest a role for proline and PRODH, the gene encoding the first enzyme in the pathway of proline catabolism, in contributing risk for schizophrenia.	Proline	146-153	sluggish A	Drosophila melanogaster	86-91
18980686-4	2008	METHODS: Here we studied whether two single nucleotide sequence variants, c.1744 C&gt;T that changes residue 582 of HIF-1alpha from proline to serine (P582S) and c.1762 G&gt;A that changes residue 588 of HIF-1alpha from alanine to threonine (A588T) in the exon 12 of the HIF1A gene, are associated with pre-eclampsia.	Proline	132-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126
18320291-1	2008	Prolidase [EC.3.4.13.9] is a cytosolic imidodipeptidase, which specifically splits imidodipeptides with C-terminal proline or hydroxyproline.	Proline	115-122	peptidase D	Homo sapiens	0-9
18330497-3	2008	Recent evidence from studies with pigs and sheep shows that proline is a major substrate for polyamine synthesis via proline oxidase, ornithine aminotransferase, and ornithine decarboxylase in placentae.	Proline	60-67	ornithine aminotransferase, mitochondrial	Ovis aries	134-160
18340504-0	2008	Human prolidase and prolidase deficiency: an overview on the characterization of the enzyme involved in proline recycling and on the effects of its mutations.	Proline	104-111	peptidase D	Homo sapiens	6-15
18340504-2	2008	Among the peptidases, prolidase is the only metalloenzyme that cleaves the iminodipeptides containing a proline or hydroxyproline residue at the C-terminal end.	Proline	104-111	peptidase D	Homo sapiens	22-31
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Proline	256-267	aldehyde dehydrogenase 18 family member A1	Homo sapiens	10-51
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Proline	256-267	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Proline	256-267	pyrroline-5-carboxylate reductase 1	Homo sapiens	53-56
18401543-3	2008	proline dehydrogenase (POX/PRODH), catalyzes the first step in proline degradation and uses proline to generate ATP for survival or reactive oxygen species for programmed cell death.	Proline	0-7	proline dehydrogenase 1	Homo sapiens	27-32
18401543-3	2008	proline dehydrogenase (POX/PRODH), catalyzes the first step in proline degradation and uses proline to generate ATP for survival or reactive oxygen species for programmed cell death.	Proline	63-70	proline dehydrogenase 1	Homo sapiens	27-32
18778683-1	2008	Grb2-Sos1 interaction, mediated by the canonical binding of N-terminal SH3 (nSH3) and C-terminal SH3 (cSH3) domains of Grb2 to a proline-rich sequence in Sos1, provides a key regulatory switch that relays signaling from activated receptor tyrosine kinases to downstream effector molecules such as Ras.	Proline	129-136	growth factor receptor bound protein 2	Homo sapiens	0-4
18778683-1	2008	Grb2-Sos1 interaction, mediated by the canonical binding of N-terminal SH3 (nSH3) and C-terminal SH3 (cSH3) domains of Grb2 to a proline-rich sequence in Sos1, provides a key regulatory switch that relays signaling from activated receptor tyrosine kinases to downstream effector molecules such as Ras.	Proline	129-136	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	5-9
18778683-1	2008	Grb2-Sos1 interaction, mediated by the canonical binding of N-terminal SH3 (nSH3) and C-terminal SH3 (cSH3) domains of Grb2 to a proline-rich sequence in Sos1, provides a key regulatory switch that relays signaling from activated receptor tyrosine kinases to downstream effector molecules such as Ras.	Proline	129-136	growth factor receptor bound protein 2	Homo sapiens	119-123
18778683-1	2008	Grb2-Sos1 interaction, mediated by the canonical binding of N-terminal SH3 (nSH3) and C-terminal SH3 (cSH3) domains of Grb2 to a proline-rich sequence in Sos1, provides a key regulatory switch that relays signaling from activated receptor tyrosine kinases to downstream effector molecules such as Ras.	Proline	129-136	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	154-158
18778683-2	2008	Here, using isothermal titration calorimetry in combination with site-directed mutagenesis, we show that the nSH3 domain binds to a Sos1-derived peptide containing the proline-rich consensus motif PPVPPR with an affinity that is nearly threefold greater than that observed for the binding of cSH3 domain.	Proline	168-175	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	132-136
18802692-6	2008	Based on the fact that proline has stress-protective activity, S. cerevisiae cells that accumulate proline were constructed by disrupting the PUT1 gene involved in the degradation pathway and by expressing the mutant PRO1 gene encoding the feedback inhibition-less sensitive gamma-glutamate kinase to enhance the biosynthetic activity.	Proline	23-30	glutamate 5-kinase	Saccharomyces cerevisiae S288C	217-221
18802692-6	2008	Based on the fact that proline has stress-protective activity, S. cerevisiae cells that accumulate proline were constructed by disrupting the PUT1 gene involved in the degradation pathway and by expressing the mutant PRO1 gene encoding the feedback inhibition-less sensitive gamma-glutamate kinase to enhance the biosynthetic activity.	Proline	99-106	proline dehydrogenase	Saccharomyces cerevisiae S288C	142-146
18802692-6	2008	Based on the fact that proline has stress-protective activity, S. cerevisiae cells that accumulate proline were constructed by disrupting the PUT1 gene involved in the degradation pathway and by expressing the mutant PRO1 gene encoding the feedback inhibition-less sensitive gamma-glutamate kinase to enhance the biosynthetic activity.	Proline	99-106	glutamate 5-kinase	Saccharomyces cerevisiae S288C	217-221
18058229-6	2008	However, combined analysis of the SNP"s showed that p53 (Arg/Arg and Arg/Pro) with TGFbeta1 (Pro/Pro and Leu/Pro) were associated with greater than 2 fold increased risk for breast cancer in Univariate (P=0.01) and Multivariate (P=0.003) analysis.	Proline	73-76	tumor protein p53	Homo sapiens	52-55
18780184-7	2008	Initiator caspase-8, with Pro in the P5-anchoring position and no loop-4, had only 20% activity on tested pentapeptides relative to DEVD.	Proline	26-29	caspase 8	Homo sapiens	10-19
18058229-6	2008	However, combined analysis of the SNP"s showed that p53 (Arg/Arg and Arg/Pro) with TGFbeta1 (Pro/Pro and Leu/Pro) were associated with greater than 2 fold increased risk for breast cancer in Univariate (P=0.01) and Multivariate (P=0.003) analysis.	Proline	73-76	latent transforming growth factor beta binding protein 1	Homo sapiens	83-91
18695644-1	2008	BACKGROUND AND PURPOSE: Antagonism of the gastric inhibitory polypeptide (GIP) receptor with daily injection of proline-3 gastric inhibitory polypeptide ((Pro(3))GIP) can reverse or prevent many of the metabolic abnormalities associated with diet-induced obesity-diabetes (diabesity).	Proline	112-119	gastric inhibitory polypeptide	Mus musculus	74-77
18279562-0	2008	Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene and changes in serum lipids during a family-based counselling intervention among school-aged children with a family history of CVD.	Proline	13-20	neuropeptide Y	Homo sapiens	43-57
18618130-1	2008	Prolyl oligopeptidase (POP) is a serine endopeptidase that hydrolyses proline-containing peptides shorter than 30-mer, including many bioactive peptides.	Proline	70-77	prolyl endopeptidase	Mus musculus	0-21
18618130-1	2008	Prolyl oligopeptidase (POP) is a serine endopeptidase that hydrolyses proline-containing peptides shorter than 30-mer, including many bioactive peptides.	Proline	70-77	prolyl endopeptidase	Mus musculus	23-26
18544139-0	2008	The role of proline residues in the structure and function of human MT2 melatonin receptor.	Proline	12-19	metallothionein 2A	Homo sapiens	68-71
18544139-4	2008	As TM segments of MT2 receptor display several interesting differences in expression of specific proline residues compared to other rhodopsin-like receptors (rGPCRs), we investigated the role of proline residues in the structure and function of this receptor.	Proline	97-104	metallothionein 2A	Homo sapiens	18-21
18544139-4	2008	As TM segments of MT2 receptor display several interesting differences in expression of specific proline residues compared to other rhodopsin-like receptors (rGPCRs), we investigated the role of proline residues in the structure and function of this receptor.	Proline	195-202	metallothionein 2A	Homo sapiens	18-21
19526109-1	2008	The distribution of PPARG gene allele frequencies (Pro/Ala polymorphism) was studied in sportsmen specialized in speed and force athletics.	Proline	51-54	peroxisome proliferator activated receptor gamma	Homo sapiens	20-25
18957898-4	2008	The Aze hypothesis posits that myelin basic protein and possibly other closely related molecules are misassembled in sites of lesion formation because of the substitution of Aze for one or more prolines within consensual epitopes.	Proline	194-202	myelin basic protein	Homo sapiens	31-51
18768751-5	2008	A secondary interaction between ELMO1 and DOCK180 is conferred by the DOCK180 SH3 domain and proline-rich motifs at the ELMO1 C-terminus.	Proline	93-100	engulfment and cell motility 1	Homo sapiens	32-37
18768751-5	2008	A secondary interaction between ELMO1 and DOCK180 is conferred by the DOCK180 SH3 domain and proline-rich motifs at the ELMO1 C-terminus.	Proline	93-100	dedicator of cytokinesis 1	Homo sapiens	42-49
18768751-5	2008	A secondary interaction between ELMO1 and DOCK180 is conferred by the DOCK180 SH3 domain and proline-rich motifs at the ELMO1 C-terminus.	Proline	93-100	engulfment and cell motility 1	Homo sapiens	120-125
18694926-3	2008	At normoxia two specific proline residues (Pro(402) and Pro(563)) of mHIF-1alpha are hydroxylated and recognized by the von Hippel-Lindau E3 ubiquitin ligase (pVHL) complex, which upon binding mediates degradation of the protein.	Proline	25-32	hypoxia inducible factor 1, alpha subunit	Mus musculus	69-80
18955686-4	2008	RESULTS: We detected a novel mutation at codon 105 of PRNP that results in a serine (S) substitution of proline (P) (P105S), in a young woman who developed progressive aphasia, behavioral changes, dementia, and parkinsonism, lasting 10 years to her death.	Proline	104-111	prion protein	Homo sapiens	54-58
18694926-3	2008	At normoxia two specific proline residues (Pro(402) and Pro(563)) of mHIF-1alpha are hydroxylated and recognized by the von Hippel-Lindau E3 ubiquitin ligase (pVHL) complex, which upon binding mediates degradation of the protein.	Proline	25-32	von Hippel-Lindau tumor suppressor	Homo sapiens	159-163
18694926-3	2008	At normoxia two specific proline residues (Pro(402) and Pro(563)) of mHIF-1alpha are hydroxylated and recognized by the von Hippel-Lindau E3 ubiquitin ligase (pVHL) complex, which upon binding mediates degradation of the protein.	Proline	43-46	hypoxia inducible factor 1, alpha subunit	Mus musculus	69-80
18722344-1	2008	BCAR3 (breast cancer anti-estrogen resistance 3) is a signal transducer containing an SH2 domain, a proline/serine-rich domain and a GDP-exchange factor homologous domain, whose role in signaling pathways is currently unclear.	Proline	100-107	BCAR3 adaptor protein, NSP family member	Homo sapiens	0-5
18722344-1	2008	BCAR3 (breast cancer anti-estrogen resistance 3) is a signal transducer containing an SH2 domain, a proline/serine-rich domain and a GDP-exchange factor homologous domain, whose role in signaling pathways is currently unclear.	Proline	100-107	BCAR3 adaptor protein, NSP family member	Homo sapiens	7-47
18694926-3	2008	At normoxia two specific proline residues (Pro(402) and Pro(563)) of mHIF-1alpha are hydroxylated and recognized by the von Hippel-Lindau E3 ubiquitin ligase (pVHL) complex, which upon binding mediates degradation of the protein.	Proline	43-46	von Hippel-Lindau tumor suppressor	Homo sapiens	159-163
18694926-3	2008	At normoxia two specific proline residues (Pro(402) and Pro(563)) of mHIF-1alpha are hydroxylated and recognized by the von Hippel-Lindau E3 ubiquitin ligase (pVHL) complex, which upon binding mediates degradation of the protein.	Proline	56-59	hypoxia inducible factor 1, alpha subunit	Mus musculus	69-80
18694926-3	2008	At normoxia two specific proline residues (Pro(402) and Pro(563)) of mHIF-1alpha are hydroxylated and recognized by the von Hippel-Lindau E3 ubiquitin ligase (pVHL) complex, which upon binding mediates degradation of the protein.	Proline	56-59	von Hippel-Lindau tumor suppressor	Homo sapiens	159-163
18694926-4	2008	Previous studies have demonstrated that these two proline residues are critical for high affinity binding to pVHL.	Proline	50-57	von Hippel-Lindau tumor suppressor	Homo sapiens	109-113
18694926-5	2008	We have performed a detailed analysis of a mutant form of HIF-1alpha, where both these proline residues have been mutated, and we have uncovered a novel degradation pathway, to which the HIF-1alpha mutant protein is not resistant.	Proline	87-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-68
18694926-5	2008	We have performed a detailed analysis of a mutant form of HIF-1alpha, where both these proline residues have been mutated, and we have uncovered a novel degradation pathway, to which the HIF-1alpha mutant protein is not resistant.	Proline	87-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	187-197
18694926-6	2008	Our results show that the HIF-1alpha double proline mutant undergoes ubiquitination and proteasome-dependent degradation, and retains the ability to be stabilized in response to hypoxia and CoCl(2) treatment.	Proline	44-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-36
18832702-2	2008	We mapped the binding register of CLIP2 (Ii 96-104) to DQ2 and found proline at the P1 position, in contrast to the canonical CLIP1 (Ii 83-101) register with methionine at P1.	Proline	69-76	CAP-Gly domain containing linker protein 2	Homo sapiens	34-39
18588503-9	2008	Two, ASE mitochondria were able to oxidize proline at a rate comparable with that of alpha-glycerophosphate.	Proline	43-50	arylsulfatase L	Homo sapiens	5-8
18718510-1	2008	Prolyl oligopeptidase (POP) is an endopeptidase which cleaves short proline-containing neuropeptides, and it is involved in memory and learning.	Proline	68-75	prolyl endopeptidase	Homo sapiens	0-21
18718510-1	2008	Prolyl oligopeptidase (POP) is an endopeptidase which cleaves short proline-containing neuropeptides, and it is involved in memory and learning.	Proline	68-75	prolyl endopeptidase	Homo sapiens	23-26
18803191-8	2008	Two different proline-rich binding domains of the GYF family-CD2BP2 and PERQ2-were targeted by peptides labeled either C- or N-terminally.	Proline	14-21	CD2 cytoplasmic tail binding protein 2	Homo sapiens	61-67
18586328-4	2008	The putative porcine IPS-1 protein contains a N-terminal CARD-like domain, a central proline-rich domain, a C-terminal transmembrane domain, and exhibits similarity to mouse, rat, monkey, human and cattle counterparts, ranging from 59% to 79%.	Proline	85-92	mitochondrial antiviral signaling protein	Mus musculus	21-26
18803191-8	2008	Two different proline-rich binding domains of the GYF family-CD2BP2 and PERQ2-were targeted by peptides labeled either C- or N-terminally.	Proline	14-21	GRB10 interacting GYF protein 2	Homo sapiens	72-77
18557974-0	2008	A proline-to-histidine mutation in POU1F1 is associated with production traits in dairy cattle.	Proline	2-9	POU class 1 homeobox 1	Bos taurus	35-41
18855981-2	2008	METHODS: We constructed recombinant adenovirus vector expressing a mutant type p27(kip1) gene (ad-p27mt), with mutation of Thr-187/Pro-188 (ACGCCC) to Met-187/Ile-188 (ATGATC), and transduced into SW480 cells.	Proline	131-134	cyclin dependent kinase inhibitor 1B	Homo sapiens	79-88
18557974-5	2008	An SNP in exon 3 of POU1F1 that changes a proline to a histidine was identified.	Proline	42-49	POU class 1 homeobox 1	Bos taurus	20-26
18792035-1	2008	Prolyl oligopeptidase (POP) is a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy terminus of proline residues.	Proline	76-83	prolyl endopeptidase	Homo sapiens	0-21
18602463-5	2008	In vitro binding experiments narrowed the binding interfaces down to two proline-rich domains on ataxin-2, which interacted with the SH3 domain of endophilin A1/A3.	Proline	73-80	ataxin 2	Mus musculus	97-105
18602463-5	2008	In vitro binding experiments narrowed the binding interfaces down to two proline-rich domains on ataxin-2, which interacted with the SH3 domain of endophilin A1/A3.	Proline	73-80	SH3-domain GRB2-like 2	Mus musculus	147-160
18792035-1	2008	Prolyl oligopeptidase (POP) is a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy terminus of proline residues.	Proline	76-83	prolyl endopeptidase	Homo sapiens	23-26
18792035-1	2008	Prolyl oligopeptidase (POP) is a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy terminus of proline residues.	Proline	131-138	prolyl endopeptidase	Homo sapiens	0-21
18792035-1	2008	Prolyl oligopeptidase (POP) is a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy terminus of proline residues.	Proline	131-138	prolyl endopeptidase	Homo sapiens	23-26
18802088-5	2008	The ADAP proline-rich domain is sufficient to bind and stabilize the expression of SKAP55 (Src kinase-associated phosphoprotein of 55 kDa), which is otherwise absent from ADAP(-/-) T cells.	Proline	9-16	FYN binding protein	Mus musculus	4-8
18664521-1	2008	Cathepsin K is known to play an important role in bone resorption, and it has the P2 specificity for proline.	Proline	101-108	cathepsin K	Rattus norvegicus	0-11
18478038-8	2008	In an in vivo assay of flux through this metabolic pathway using dermal fibroblasts obtained from an affected individual, proline and ornithine biosynthetic activity of P5CS was not affected by the H784Y substitution.	Proline	122-129	aldehyde dehydrogenase 18 family member A1	Homo sapiens	169-173
18802088-5	2008	The ADAP proline-rich domain is sufficient to bind and stabilize the expression of SKAP55 (Src kinase-associated phosphoprotein of 55 kDa), which is otherwise absent from ADAP(-/-) T cells.	Proline	9-16	src family associated phosphoprotein 1	Mus musculus	83-89
18802088-5	2008	The ADAP proline-rich domain is sufficient to bind and stabilize the expression of SKAP55 (Src kinase-associated phosphoprotein of 55 kDa), which is otherwise absent from ADAP(-/-) T cells.	Proline	9-16	src family associated phosphoprotein 1	Mus musculus	91-137
18802088-7	2008	Additionally, the ADAP proline-rich domain is required for optimal Ag-induced activation of CD69, CD25, and Bcl-x(L), but is not required for assembly of the CARMA1/Bcl10/Malt1 (caspase-recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1/B-cell CLL-lymphoma 10/mucosa-associated lymphoid tissue lymphoma translocation protein 1) signaling complex and subsequent TCR-dependent NF-kappaB activity.	Proline	23-30	FYN binding protein	Mus musculus	18-22
18802088-7	2008	Additionally, the ADAP proline-rich domain is required for optimal Ag-induced activation of CD69, CD25, and Bcl-x(L), but is not required for assembly of the CARMA1/Bcl10/Malt1 (caspase-recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1/B-cell CLL-lymphoma 10/mucosa-associated lymphoid tissue lymphoma translocation protein 1) signaling complex and subsequent TCR-dependent NF-kappaB activity.	Proline	23-30	CD69 antigen	Mus musculus	92-96
18802088-7	2008	Additionally, the ADAP proline-rich domain is required for optimal Ag-induced activation of CD69, CD25, and Bcl-x(L), but is not required for assembly of the CARMA1/Bcl10/Malt1 (caspase-recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1/B-cell CLL-lymphoma 10/mucosa-associated lymphoid tissue lymphoma translocation protein 1) signaling complex and subsequent TCR-dependent NF-kappaB activity.	Proline	23-30	interleukin 2 receptor, alpha chain	Mus musculus	98-102
18802088-7	2008	Additionally, the ADAP proline-rich domain is required for optimal Ag-induced activation of CD69, CD25, and Bcl-x(L), but is not required for assembly of the CARMA1/Bcl10/Malt1 (caspase-recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1/B-cell CLL-lymphoma 10/mucosa-associated lymphoid tissue lymphoma translocation protein 1) signaling complex and subsequent TCR-dependent NF-kappaB activity.	Proline	23-30	BCL2-like 1	Mus musculus	108-113
18802088-7	2008	Additionally, the ADAP proline-rich domain is required for optimal Ag-induced activation of CD69, CD25, and Bcl-x(L), but is not required for assembly of the CARMA1/Bcl10/Malt1 (caspase-recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1/B-cell CLL-lymphoma 10/mucosa-associated lymphoid tissue lymphoma translocation protein 1) signaling complex and subsequent TCR-dependent NF-kappaB activity.	Proline	23-30	T cell receptor alpha variable 6-3	Mus musculus	391-394
18280134-1	2008	Ornithine aminotransferase (OAT) is a crucial enzyme in the synthesis of citrulline and arginine from glutamine/glutamate and proline by enterocytes of the small intestine.	Proline	126-133	ornithine aminotransferase	Homo sapiens	28-31
18806115-4	2008	The intestine expresses pyrroline 5-carboxylate (P5C) synthase, which means that proline is an end product of intestinal glutamine catabolism.	Proline	81-88	pyrroline-5-carboxylate reductase 1	Homo sapiens	24-47
18806115-4	2008	The intestine expresses pyrroline 5-carboxylate (P5C) synthase, which means that proline is an end product of intestinal glutamine catabolism.	Proline	81-88	pyrroline-5-carboxylate reductase 1	Homo sapiens	49-52
18806097-9	2008	However, the inhibitory actions of AICAR were associated with reduced phosphorylation of proline-rich Akt substrate-40 and increased phosphorylation of raptor, which represent potential mechanisms by which AICAR might be expected to inhibit leucine-induced increases in mTOR activity and protein synthesis under in vivo conditions.	Proline	89-96	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	35-40
18806116-4	2008	Studies show that the proline-utilizing enzyme, proline oxidase (POX)/proline dehydrogenase (PRODH), responds to genotoxic, inflammatory, and nutrient stress.	Proline	22-29	proline dehydrogenase 1	Homo sapiens	48-63
18806097-9	2008	However, the inhibitory actions of AICAR were associated with reduced phosphorylation of proline-rich Akt substrate-40 and increased phosphorylation of raptor, which represent potential mechanisms by which AICAR might be expected to inhibit leucine-induced increases in mTOR activity and protein synthesis under in vivo conditions.	Proline	89-96	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	206-211
18806116-4	2008	Studies show that the proline-utilizing enzyme, proline oxidase (POX)/proline dehydrogenase (PRODH), responds to genotoxic, inflammatory, and nutrient stress.	Proline	22-29	proline dehydrogenase 1	Homo sapiens	65-68
18806116-4	2008	Studies show that the proline-utilizing enzyme, proline oxidase (POX)/proline dehydrogenase (PRODH), responds to genotoxic, inflammatory, and nutrient stress.	Proline	22-29	proline dehydrogenase 1	Homo sapiens	93-98
18806116-5	2008	Proline as substrate is stored as collagen in extracellular matrix, connective tissue, and bone and it is rapidly released from this reservoir by the sequential action of matrix metalloproteinases, peptidases, and prolidase.	Proline	0-7	peptidase D	Homo sapiens	214-223
18806116-6	2008	Special functions include the use of proline by POX/PRODH to generate superoxide radicals that initiate apoptosis by intrinsic and extrinsic pathways.	Proline	37-44	proline dehydrogenase 1	Homo sapiens	48-51
18806116-6	2008	Special functions include the use of proline by POX/PRODH to generate superoxide radicals that initiate apoptosis by intrinsic and extrinsic pathways.	Proline	37-44	proline dehydrogenase 1	Homo sapiens	52-57
18806117-1	2008	l-Proline concentration is primarily related to the balance of enzymatic activities of proline dehydrogenase [proline oxidase (POX)] and Delta-1-pyrroline-5-carboxylate (P5C) reductase.	Proline	0-9	proline dehydrogenase 1	Homo sapiens	127-130
18806117-1	2008	l-Proline concentration is primarily related to the balance of enzymatic activities of proline dehydrogenase [proline oxidase (POX)] and Delta-1-pyrroline-5-carboxylate (P5C) reductase.	Proline	0-9	pyrroline-5-carboxylate reductase 1	Homo sapiens	137-168
18806117-1	2008	l-Proline concentration is primarily related to the balance of enzymatic activities of proline dehydrogenase [proline oxidase (POX)] and Delta-1-pyrroline-5-carboxylate (P5C) reductase.	Proline	0-9	pyrroline-5-carboxylate reductase 1	Homo sapiens	170-173
18806117-2	2008	As a result, P5C plays a pivotal role in maintaining the concentration of proline in body fluids and inborn errors of P5C metabolism lead to disturbance of proline metabolism.	Proline	74-81	pyrroline-5-carboxylate reductase 1	Homo sapiens	13-16
18806117-2	2008	As a result, P5C plays a pivotal role in maintaining the concentration of proline in body fluids and inborn errors of P5C metabolism lead to disturbance of proline metabolism.	Proline	156-163	pyrroline-5-carboxylate reductase 1	Homo sapiens	13-16
18806117-2	2008	As a result, P5C plays a pivotal role in maintaining the concentration of proline in body fluids and inborn errors of P5C metabolism lead to disturbance of proline metabolism.	Proline	156-163	pyrroline-5-carboxylate reductase 1	Homo sapiens	118-121
18806117-16	2008	Prolidase catalyzes hydrolysis of dipeptide or oligopeptide with a C-terminal proline or hydroxyproline and its deficiency can cause mental retardation and severe skin ulcers.	Proline	78-85	peptidase D	Homo sapiens	0-9
18806120-1	2008	The cellular metabolism of glutamine and proline are closely interrelated, because they can be interconverted with glutamate and ornithine via the mitochondrial pathway involving pyrroline-5-carboxylate (P5C).	Proline	41-48	pyrroline-5-carboxylate reductase 1	Homo sapiens	204-207
18806120-2	2008	In adults, glutamine and proline are converted via P5C to citrulline in the gut, then citrulline is converted to arginine in the kidney.	Proline	25-32	pyrroline-5-carboxylate reductase 1	Homo sapiens	51-54
18514177-5	2008	AChE(T) subunits associate with a collagen tail subunit (ColQ) forming asymmetric AChE species (A(4), A(8), and A(12) AChE) in muscle, and also form amphiphilic tetramers associated with a proline-rich membrane anchor (PRiMA) as globular AChE (G(4) AChE) in brain and muscle.	Proline	189-196	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-4
18598727-1	2008	The first naturally occurring angiotensin-converting enzyme (ACE) inhibitors described are pyroglutamyl proline-rich oligopeptides, found in the venom of the viper Bothrops jararaca, and named as bradykinin-potentiating peptides (BPPs).	Proline	104-111	angiotensin I converting enzyme	Homo sapiens	61-64
18598727-1	2008	The first naturally occurring angiotensin-converting enzyme (ACE) inhibitors described are pyroglutamyl proline-rich oligopeptides, found in the venom of the viper Bothrops jararaca, and named as bradykinin-potentiating peptides (BPPs).	Proline	104-111	kininogen 1	Homo sapiens	196-206
18342899-4	2008	SH2-Src interacts with a phosphotyrosine residue of ER and SH3-Src interacts with a proline rich sequence of AR.	Proline	84-91	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	4-7
18342899-4	2008	SH2-Src interacts with a phosphotyrosine residue of ER and SH3-Src interacts with a proline rich sequence of AR.	Proline	84-91	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	63-66
18644377-4	2008	Since post-translational proline hydroxylation is an important step in the synthesis of collagen chains, we used the DNA sequence for the alpha1 and alpha2 chains of human type I collagen, and the known amino acid sequences for bovine and chicken type I collagen, to infer which prolines are hydroxylated in the vicinity of the collagenase cleavage site.	Proline	25-32	adrenoceptor alpha 1D	Homo sapiens	138-155
18644377-8	2008	Surprisingly, our data also imply that alpha2 chain unfolding is mediated by the non-hydroxylation of a proline residue that is N-terminal to the cleavage site in alpha1 chains.	Proline	104-111	adrenoceptor alpha 1D	Homo sapiens	163-169
18561906-0	2008	The promoter activity of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in muscle: suppressive roles of myogenesis and innervating nerve.	Proline	25-32	proline rich membrane anchor 1	Homo sapiens	55-60
18561906-2	2008	The assembly and membrane targeting of G(4) AChE are directed by a proline-rich membrane anchor (PRiMA).	Proline	67-74	proline rich membrane anchor 1	Homo sapiens	97-102
18514177-5	2008	AChE(T) subunits associate with a collagen tail subunit (ColQ) forming asymmetric AChE species (A(4), A(8), and A(12) AChE) in muscle, and also form amphiphilic tetramers associated with a proline-rich membrane anchor (PRiMA) as globular AChE (G(4) AChE) in brain and muscle.	Proline	189-196	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	57-61
18514641-1	2008	The catalytic subunit of acetylcholinesterase (AChE(T)) interacts with proline-rich membrane anchor (PRiMA) to form PRiMA-linked G(4) AChE on membrane surface for its cholinergic function.	Proline	71-78	acetylcholinesterase	Rattus norvegicus	47-51
18514641-1	2008	The catalytic subunit of acetylcholinesterase (AChE(T)) interacts with proline-rich membrane anchor (PRiMA) to form PRiMA-linked G(4) AChE on membrane surface for its cholinergic function.	Proline	71-78	proline rich membrane anchor 1	Rattus norvegicus	101-106
18514641-1	2008	The catalytic subunit of acetylcholinesterase (AChE(T)) interacts with proline-rich membrane anchor (PRiMA) to form PRiMA-linked G(4) AChE on membrane surface for its cholinergic function.	Proline	71-78	proline rich membrane anchor 1	Rattus norvegicus	116-121
18514641-1	2008	The catalytic subunit of acetylcholinesterase (AChE(T)) interacts with proline-rich membrane anchor (PRiMA) to form PRiMA-linked G(4) AChE on membrane surface for its cholinergic function.	Proline	71-78	acetylcholinesterase	Rattus norvegicus	134-138
18690212-6	2008	Mass spectrometric analysis identified hydroxylation of the endogenous Ago2 at proline 700.	Proline	79-86	argonaute RISC catalytic component 2	Homo sapiens	71-75
18757753-4	2008	By sequential substitution of residues 5-55 of Sup35 by proline and insertion of glycine at alternate sites in this segment, specific mutations have been identified that interfere selectively with the propagation of each of the three prion strains in yeast: the [VH] strain requires amino acid residues 7-21; [VK] requires residues 9-37; and [VL] requires residues 5 to at least 52.	Proline	56-63	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	47-52
18599481-4	2008	Mammals produce four alternatively spliced variants of Numb that differ in the length of their PTB and proline-rich region.	Proline	103-110	NUMB endocytic adaptor protein	Homo sapiens	55-59
18781154-2	2008	Specifically, two polymorphisms in p53, c.97-147ins16bp and p.Arg72Pro have been analysed as putative breast cancer susceptibility variants, and it has been recently reported that a p53 haplotype combining the absence of the 16-bp insertion and the presence of proline at codon 72 (No Ins-72Pro) was associated with an earlier age at the onset of the first primary tumour in BRCA2 mutation carriers in the Spanish population.	Proline	261-268	tumor protein p53	Homo sapiens	35-38
18781154-2	2008	Specifically, two polymorphisms in p53, c.97-147ins16bp and p.Arg72Pro have been analysed as putative breast cancer susceptibility variants, and it has been recently reported that a p53 haplotype combining the absence of the 16-bp insertion and the presence of proline at codon 72 (No Ins-72Pro) was associated with an earlier age at the onset of the first primary tumour in BRCA2 mutation carriers in the Spanish population.	Proline	261-268	tumor protein p53	Homo sapiens	182-185
18794110-6	2008	Using a computational virtual screening strategy, we have identified a unique small molecule inhibitor that serves as a suicide substrate for MIF, resulting in the covalent modification of the catalytically active NH(2)-terminal proline.	Proline	229-236	macrophage migration inhibitory factor	Homo sapiens	142-145
18707164-2	2008	The result of the calculation, based on structures from nanosecond molecular dynamics simulation, revealed that (19)Phe, (22)Leu, and (23)Trp of p53 have the strongest binding interaction with MDM2 followed by (26)Leu and (27)Pro.	Proline	226-229	tumor protein p53	Homo sapiens	145-148
18707164-2	2008	The result of the calculation, based on structures from nanosecond molecular dynamics simulation, revealed that (19)Phe, (22)Leu, and (23)Trp of p53 have the strongest binding interaction with MDM2 followed by (26)Leu and (27)Pro.	Proline	226-229	MDM2 proto-oncogene	Homo sapiens	193-197
18559951-5	2008	In contrast to other transmembrane adaptor proteins, GAPT is not phosphorylated upon BCR ligation but associates with Grb2 constitutively through its proline-rich region.	Proline	150-157	Grb2-binding adaptor, transmembrane	Mus musculus	53-57
18606821-7	2008	Although the activation domain of Noxa1 was not required for Duox function, mutation of a proline-rich domain in the Duox C terminus, a potential interaction motif for the Noxa1 Src homology domain 3, caused up-regulation of basal and stimulated H2O2 production.	Proline	90-97	NADPH oxidase activator 1	Homo sapiens	172-177
18621125-4	2008	Transepithelial transport of the prototypic hPAT1 (SLC36A1) substrates l-proline and glycine were maximal after 21-28 days in culture.	Proline	71-80	solute carrier family 36 member 1	Homo sapiens	44-49
18621125-4	2008	Transepithelial transport of the prototypic hPAT1 (SLC36A1) substrates l-proline and glycine were maximal after 21-28 days in culture.	Proline	71-80	solute carrier family 36 member 1	Homo sapiens	51-58
18698492-2	2008	We report on a previously uncharacterized Pro/Ser (C to T) polymorphism at amino acid 176 of the human maspin protein.	Proline	42-45	serpin family B member 5	Homo sapiens	103-109
18698492-7	2008	Stable expression of the Pro and Ser forms of maspin in lung cancer cells revealed that cells expressing Ser176 maspin showed significantly decreased apoptosis and increased colony formation compared with those expressing Pro176 maspin.	Proline	25-28	serpin family B member 5	Homo sapiens	112-118
18698492-7	2008	Stable expression of the Pro and Ser forms of maspin in lung cancer cells revealed that cells expressing Ser176 maspin showed significantly decreased apoptosis and increased colony formation compared with those expressing Pro176 maspin.	Proline	25-28	serpin family B member 5	Homo sapiens	112-118
18768695-0	2008	Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity.	Proline	24-31	huntingtin	Homo sapiens	55-65
18768695-3	2008	However, other parts of the protein, including the 17 N-terminal amino acids and two proline (polyP) repeat domains, regulate the toxicity of mutant Htt.	Proline	85-92	huntingtin	Homo sapiens	149-152
19240858-5	2008	A relationship between HIF1A Ser allele and predominance of fast-twitch muscle fibers was shown (Pro/Ser 46.2 (13.8)%, Pro/Pro 31.4 (8.2)%; p=0.007).	Proline	97-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-28
19240858-5	2008	A relationship between HIF1A Ser allele and predominance of fast-twitch muscle fibers was shown (Pro/Ser 46.2 (13.8)%, Pro/Pro 31.4 (8.2)%; p=0.007).	Proline	119-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-28
19240858-5	2008	A relationship between HIF1A Ser allele and predominance of fast-twitch muscle fibers was shown (Pro/Ser 46.2 (13.8)%, Pro/Pro 31.4 (8.2)%; p=0.007).	Proline	119-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-28
18657187-1	2008	Prolyl oligopeptidase (POP) is a serine protease that cleaves small peptides at the carboxyl side of an internal proline residue.	Proline	113-120	prolyl endopeptidase	Homo sapiens	0-21
18657187-1	2008	Prolyl oligopeptidase (POP) is a serine protease that cleaves small peptides at the carboxyl side of an internal proline residue.	Proline	113-120	prolyl endopeptidase	Homo sapiens	23-26
18482983-8	2008	Further, we identify SHP-2 and PTP-PEST (protein-tyrosine phosphatase proline-, glutamate-, serine-, and threonine-rich sequence) as negative regulators of c-Src kinase and demonstrate a new function for these phosphatases in intestinal cell migration.	Proline	70-77	protein tyrosine phosphatase, non-receptor type 12	Mus musculus	31-39
18523967-2	2008	The thioxo analog Phe(1)-Tyr(2)-psi[CS-N]-Pro(3)-Trp(4)-Gly(5)-NH(2) (psi[CS-N](2)-kinin), was synthesized by Fmoc solid-phase peptide strategy.	Proline	41-45	transient receptor potential cation channel subfamily C member 4	Homo sapiens	49-54
18758421-2	2008	A common polymorphism at codon 72 of exon 4 of the p53 gene encoding either an arginine or proline has been shown to confer susceptibility to the development of different human malignancies.	Proline	91-98	tumor protein p53	Homo sapiens	51-54
18578010-3	2008	Hypoxia-responsive cis elements were used in tandem with a single proline-modified oxygen-dependent degradation (ODD) domain of hypoxia-inducible factor-1alpha to form a double oxygen-sensing vector system (DOSVS).	Proline	66-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-159
18988066-4	2008	Proline residues in transmembrane helices H1, H3 and H5 appear to form dynamic hinges.	Proline	0-7	H1.5 linker histone, cluster member	Homo sapiens	42-55
18503779-3	2008	However, under hypoxic conditions, the ubiquitination system for HIF-1 alpha is inhibited by inactivation of prolyl hydroxylase which is responsible for hydroxylation of proline in the oxygen-dependent degradation domain of HIF-1 alpha.	Proline	170-177	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-76
18503779-3	2008	However, under hypoxic conditions, the ubiquitination system for HIF-1 alpha is inhibited by inactivation of prolyl hydroxylase which is responsible for hydroxylation of proline in the oxygen-dependent degradation domain of HIF-1 alpha.	Proline	170-177	hypoxia inducible factor 1 subunit alpha	Homo sapiens	224-235
18680311-2	2008	The SH3 domains of CIN85 bind to a proline-rich region of Cbl.	Proline	35-42	Cbl proto-oncogene	Homo sapiens	58-61
18707241-0	2008	The proline-rich region of HIV-1 Nef affects CXCR4-mediated chemotaxis in Jurkat T cells.	Proline	4-11	Nef	Human immunodeficiency virus 1	33-36
18707241-0	2008	The proline-rich region of HIV-1 Nef affects CXCR4-mediated chemotaxis in Jurkat T cells.	Proline	4-11	C-X-C motif chemokine receptor 4	Homo sapiens	45-50
18707241-7	2008	We report that disruption of the proline-rich region of Nef inhibits T-cell migration to SDF-1 alpha.	Proline	33-40	S100 calcium binding protein B	Homo sapiens	56-59
18680311-2	2008	The SH3 domains of CIN85 bind to a proline-rich region of Cbl.	Proline	35-42	SH3 domain containing kinase binding protein 1	Homo sapiens	19-24
18482983-8	2008	Further, we identify SHP-2 and PTP-PEST (protein-tyrosine phosphatase proline-, glutamate-, serine-, and threonine-rich sequence) as negative regulators of c-Src kinase and demonstrate a new function for these phosphatases in intestinal cell migration.	Proline	70-77	c-src tyrosine kinase	Mus musculus	156-168
18571832-2	2008	PELP1 contains ten nuclear receptor-interacting boxes (LXXLL motifs), which allow it to interact with ER and other nuclear hormone receptors, a zinc finger, a glutamic acid-rich domain, and two proline-rich domains.	Proline	194-201	proline, glutamate and leucine rich protein 1	Homo sapiens	0-5
18571832-3	2008	The proline-rich regions contain several consensus PXXP motifs, which allow PELP1 to couple the ER with SH3 domain-containing kinase signaling proteins, such as Src and PI3K P85 regulatory subunit.	Proline	4-11	proline, glutamate and leucine rich protein 1	Homo sapiens	76-81
18571832-3	2008	The proline-rich regions contain several consensus PXXP motifs, which allow PELP1 to couple the ER with SH3 domain-containing kinase signaling proteins, such as Src and PI3K P85 regulatory subunit.	Proline	4-11	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	161-164
18541536-5	2008	The proline-rich Lck SH3-binding site on TSAd as well as the Lck SH2 domain were required for efficient tyrosine phosphorylation of TSAd by Lck.	Proline	4-11	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	17-20
18541536-5	2008	The proline-rich Lck SH3-binding site on TSAd as well as the Lck SH2 domain were required for efficient tyrosine phosphorylation of TSAd by Lck.	Proline	4-11	SH2 domain containing 2A	Homo sapiens	41-45
18541536-5	2008	The proline-rich Lck SH3-binding site on TSAd as well as the Lck SH2 domain were required for efficient tyrosine phosphorylation of TSAd by Lck.	Proline	4-11	SH2 domain containing 2A	Homo sapiens	132-136
18650094-1	2008	Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy terminus of proline residues.	Proline	70-77	prolyl endopeptidase	Homo sapiens	0-21
18550644-5	2008	Here, we reported that an NH2-terminal proline-rich domain (N-PRD; amino acids 1-119) is necessary and sufficient for WNK1 inhibition of ROMK1.	Proline	39-46	WNK lysine deficient protein kinase 1	Homo sapiens	118-122
18550644-5	2008	Here, we reported that an NH2-terminal proline-rich domain (N-PRD; amino acids 1-119) is necessary and sufficient for WNK1 inhibition of ROMK1.	Proline	39-46	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	137-142
18510673-6	2008	RESULTS: We found that the p53 Proline (Pro) allele was positively associated with childhood tanning response only among black/dark brown-haired women.	Proline	31-38	tumor protein p53	Homo sapiens	27-30
18650094-1	2008	Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy terminus of proline residues.	Proline	125-132	prolyl endopeptidase	Homo sapiens	0-21
18480044-7	2008	Replacement of TM3 with a secretory reporter domain or introduction of proline residues into TM3 changed the TM2 cross-linking profile and this biphasic behavior.	Proline	71-78	tropomyosin 3	Homo sapiens	93-96
18607169-1	2008	OBJECTIVES: Prolidase is a cytosolic exopeptidase that cleaves iminodipeptides with carboxy-terminal proline or hydroxyproline and plays major role in collagen turnover.	Proline	101-108	peptidase D	Homo sapiens	12-21
18422672-2	2008	Brain natriuretic peptide (BNP) and its biologically inactive fragment N-terminal pro-BNP (NT-pro-BNP) are secreted by the heart in response to myocardial stretch.	Proline	82-85	natriuretic peptide B	Homo sapiens	86-89
18422672-2	2008	Brain natriuretic peptide (BNP) and its biologically inactive fragment N-terminal pro-BNP (NT-pro-BNP) are secreted by the heart in response to myocardial stretch.	Proline	82-85	natriuretic peptide B	Homo sapiens	86-89
18971538-8	2008	In cultured VSMCs, [3H]TdR and [3H]proline incorporation stimulated by angiotensin II was inhibited by incubation with NaHS.	Proline	35-42	angiotensinogen	Rattus norvegicus	71-85
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Proline	18-21	chemokine like factor	Homo sapiens	83-88
18620523-3	2008	RESULTS/CONCLUSION: Grb2 is a key molecule in intracellular signal transduction, linking activated cell surface receptors to downstream targets by binding to specific phosphotyrosine-containing and proline-rich sequence motifs.	Proline	198-205	growth factor receptor bound protein 2	Homo sapiens	20-24
18625006-10	2008	Bat2p was found to be less specific and used proline, lysine, tyrosine and glutamate as amino donors in addition to the branched chain amino acids.	Proline	45-52	branched-chain-amino-acid transaminase BAT2	Saccharomyces cerevisiae S288C	0-5
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Proline	18-21	chemokine like factor	Homo sapiens	72-77
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Proline	18-21	chemokine like factor	Homo sapiens	83-88
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Proline	18-21	chemokine like factor	Homo sapiens	83-88
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Proline	18-21	chemokine like factor	Homo sapiens	83-88
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Proline	18-21	chemokine like factor	Homo sapiens	83-88
18573890-1	2008	The signal-transducing adaptor protein 2 (STAP-2) is a recently identified adaptor protein that contains a pleckstrin homology (PH) and Src homology 2 (SH2)-like domains, as well as a proline-rich domain in its C-terminal region.	Proline	184-191	signal transducing adaptor family member 2	Homo sapiens	4-40
18573890-1	2008	The signal-transducing adaptor protein 2 (STAP-2) is a recently identified adaptor protein that contains a pleckstrin homology (PH) and Src homology 2 (SH2)-like domains, as well as a proline-rich domain in its C-terminal region.	Proline	184-191	signal transducing adaptor family member 2	Homo sapiens	42-48
18511416-1	2008	Acetylcholinesterase tetramers are inserted in the basal lamina of neuromuscular junctions or anchored in cell membranes through the interaction of four C-terminal t peptides with proline-rich attachment domains (PRADs) of cholinesterase-associated collagen Q (ColQ) or of the transmembrane protein PRiMA (proline-rich membrane anchor).	Proline	180-187	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
18511416-1	2008	Acetylcholinesterase tetramers are inserted in the basal lamina of neuromuscular junctions or anchored in cell membranes through the interaction of four C-terminal t peptides with proline-rich attachment domains (PRADs) of cholinesterase-associated collagen Q (ColQ) or of the transmembrane protein PRiMA (proline-rich membrane anchor).	Proline	180-187	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	261-265
18511416-1	2008	Acetylcholinesterase tetramers are inserted in the basal lamina of neuromuscular junctions or anchored in cell membranes through the interaction of four C-terminal t peptides with proline-rich attachment domains (PRADs) of cholinesterase-associated collagen Q (ColQ) or of the transmembrane protein PRiMA (proline-rich membrane anchor).	Proline	180-187	proline rich membrane anchor 1	Homo sapiens	299-304
18511416-1	2008	Acetylcholinesterase tetramers are inserted in the basal lamina of neuromuscular junctions or anchored in cell membranes through the interaction of four C-terminal t peptides with proline-rich attachment domains (PRADs) of cholinesterase-associated collagen Q (ColQ) or of the transmembrane protein PRiMA (proline-rich membrane anchor).	Proline	180-187	proline rich membrane anchor 1	Homo sapiens	306-334
18511416-2	2008	ColQ and PRiMA differ in the length of their proline-rich motifs (10 and 15 residues, respectively).	Proline	45-52	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	0-4
18511416-2	2008	ColQ and PRiMA differ in the length of their proline-rich motifs (10 and 15 residues, respectively).	Proline	45-52	proline rich membrane anchor 1	Homo sapiens	9-14
18549281-3	2008	B3LYP/6-31+G** calculations provide a good explanation for the opposite syn vs anti diastereoselectivity of these two kinds of amino acid catalysts (anti-selectivity for the secondary cyclic amino acids proline, syn-selectivity for the acyclic primary amino acids like threonine).	Proline	203-210	synemin	Homo sapiens	72-75
18647389-0	2008	The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins.	Proline	12-19	RALBP1 associated Eps domain containing 2	Homo sapiens	35-39
18647389-0	2008	The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins.	Proline	12-19	RALBP1 associated Eps domain containing 2	Homo sapiens	40-45
18647389-0	2008	The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins.	Proline	12-19	epidermal growth factor receptor	Homo sapiens	73-105
18647389-3	2008	RESULTS: In this report we characterize the central proline rich domain of POB1/REPS2 and we describe for the first time its functional role in receptor endocytosis.	Proline	52-59	RALBP1 associated Eps domain containing 2	Homo sapiens	75-79
18647389-3	2008	RESULTS: In this report we characterize the central proline rich domain of POB1/REPS2 and we describe for the first time its functional role in receptor endocytosis.	Proline	52-59	RALBP1 associated Eps domain containing 2	Homo sapiens	80-85
18456661-8	2008	This study also shows that the NHR3 and NHR4 domains of CBFA2T3 interact with a conserved proline-rich region located within the C terminus of ZNF652.	Proline	90-97	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	56-63
18448430-0	2008	The structure and interactions of the proline-rich domain of ASPP2.	Proline	38-45	tumor protein p53 binding protein 2	Homo sapiens	61-66
18490454-6	2008	Moreover, Cdk5 (cyclin-dependent kinase 5), a proline-directed Ser/Thr kinase, additionally increases p53 stability via post-translational modification of p53 in response to hydrogen peroxide.	Proline	46-53	cyclin dependent kinase 5	Homo sapiens	10-14
18490454-6	2008	Moreover, Cdk5 (cyclin-dependent kinase 5), a proline-directed Ser/Thr kinase, additionally increases p53 stability via post-translational modification of p53 in response to hydrogen peroxide.	Proline	46-53	cyclin dependent kinase 5	Homo sapiens	16-41
18490454-6	2008	Moreover, Cdk5 (cyclin-dependent kinase 5), a proline-directed Ser/Thr kinase, additionally increases p53 stability via post-translational modification of p53 in response to hydrogen peroxide.	Proline	46-53	tumor protein p53	Homo sapiens	102-105
18490454-6	2008	Moreover, Cdk5 (cyclin-dependent kinase 5), a proline-directed Ser/Thr kinase, additionally increases p53 stability via post-translational modification of p53 in response to hydrogen peroxide.	Proline	46-53	tumor protein p53	Homo sapiens	155-158
18448430-3	2008	It also contains a proline-rich domain (ASPP2 Pro), whose structure and function are unclear.	Proline	19-26	tumor protein p53 binding protein 2	Homo sapiens	40-45
18456661-8	2008	This study also shows that the NHR3 and NHR4 domains of CBFA2T3 interact with a conserved proline-rich region located within the C terminus of ZNF652.	Proline	90-97	zinc finger protein 652	Homo sapiens	143-149
18448430-9	2008	This suggested that the presence of the proline-rich domain inhibited the interactions mediated by the Ank-SH3 domains.	Proline	40-47	ankyrin 1	Homo sapiens	103-106
18566390-0	2008	The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling.	Proline	4-11	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	29-39
18443110-0	2008	A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibility.	Proline	22-29	1,3-beta-D-glucan synthase	Saccharomyces cerevisiae S288C	62-67
18408040-2	2008	Residue Pro(32) has a trans conformation in the fibril state of the peptide, while it adopts a cis conformation in the native state of full-length beta(2)m.	Proline	8-11	beta-2-microglobulin	Homo sapiens	147-155
18560762-7	2008	Although the SH3 domain binds weakly and transiently to proline-rich peptides from FAK, the interaction is not very dynamic and the relative position of the spin-label to the protein is well-defined.	Proline	56-63	protein tyrosine kinase 2	Homo sapiens	83-86
18346204-4	2008	Also, p85 can indirectly bind to Axl via an interaction between p85"s second proline-rich region and the N-terminal SH3 domain of Grb2.	Proline	77-84	extracellular matrix protein 1	Mus musculus	6-9
18346204-4	2008	Also, p85 can indirectly bind to Axl via an interaction between p85"s second proline-rich region and the N-terminal SH3 domain of Grb2.	Proline	77-84	AXL receptor tyrosine kinase	Mus musculus	33-36
18346204-4	2008	Also, p85 can indirectly bind to Axl via an interaction between p85"s second proline-rich region and the N-terminal SH3 domain of Grb2.	Proline	77-84	extracellular matrix protein 1	Mus musculus	64-67
18346204-4	2008	Also, p85 can indirectly bind to Axl via an interaction between p85"s second proline-rich region and the N-terminal SH3 domain of Grb2.	Proline	77-84	growth factor receptor bound protein 2	Mus musculus	130-134
18417573-4	2008	Results indicate that PLK1 is engaged by Nipah virus V protein amino acids 100 to 160, previously identified as being the STAT1 binding domain responsible for host interferon (IFN) signaling evasion, via a Thr-Ser-Ser-Pro motif surrounding residue 130.	Proline	218-221	polo like kinase 1	Homo sapiens	22-26
18417573-4	2008	Results indicate that PLK1 is engaged by Nipah virus V protein amino acids 100 to 160, previously identified as being the STAT1 binding domain responsible for host interferon (IFN) signaling evasion, via a Thr-Ser-Ser-Pro motif surrounding residue 130.	Proline	218-221	signal transducer and activator of transcription 1	Homo sapiens	122-127
18417573-4	2008	Results indicate that PLK1 is engaged by Nipah virus V protein amino acids 100 to 160, previously identified as being the STAT1 binding domain responsible for host interferon (IFN) signaling evasion, via a Thr-Ser-Ser-Pro motif surrounding residue 130.	Proline	218-221	interferon alpha 1	Homo sapiens	164-174
18417573-4	2008	Results indicate that PLK1 is engaged by Nipah virus V protein amino acids 100 to 160, previously identified as being the STAT1 binding domain responsible for host interferon (IFN) signaling evasion, via a Thr-Ser-Ser-Pro motif surrounding residue 130.	Proline	218-221	interferon alpha 1	Homo sapiens	176-179
18417573-5	2008	A distinct Ser-Thr-Pro motif surrounding residue 199 mediates the PLK1 interaction with Hendra virus V protein.	Proline	19-22	polo like kinase 1	Homo sapiens	66-70
18426857-7	2008	Instead, it blocked the interaction between VHL and the proline-hydroxylated HIF-1alpha, but only when the reducing agents Fe(II) and vitamin C were limiting.	Proline	56-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-87
18499195-1	2008	Brain-derived neurotrophic factor (BDNF) is known to activate proline-directed Ser/Thr protein kinases and to enhance glutamatergic transmission via a Rab3a-dependent molecular pathway.	Proline	62-69	brain derived neurotrophic factor	Mus musculus	0-33
18499195-1	2008	Brain-derived neurotrophic factor (BDNF) is known to activate proline-directed Ser/Thr protein kinases and to enhance glutamatergic transmission via a Rab3a-dependent molecular pathway.	Proline	62-69	brain derived neurotrophic factor	Mus musculus	35-39
18499195-6	2008	Using in vitro phosphorylation assays we identified two novel phosphorylation sites, Ser447 and Ser745 that were substrates for ERK2, a proline-directed kinase known to be activated by BDNF.	Proline	136-143	mitogen-activated protein kinase 1	Mus musculus	128-132
18499195-6	2008	Using in vitro phosphorylation assays we identified two novel phosphorylation sites, Ser447 and Ser745 that were substrates for ERK2, a proline-directed kinase known to be activated by BDNF.	Proline	136-143	brain derived neurotrophic factor	Mus musculus	185-189
18413366-5	2008	We further demonstrated that GPC3 bound specifically through its N-terminal proline-rich region to both Insulin-like growth factor (IGF)-II and IGF-1R.	Proline	76-83	glypican 3	Homo sapiens	29-33
18413366-5	2008	We further demonstrated that GPC3 bound specifically through its N-terminal proline-rich region to both Insulin-like growth factor (IGF)-II and IGF-1R.	Proline	76-83	insulin like growth factor 2	Homo sapiens	104-139
18413366-5	2008	We further demonstrated that GPC3 bound specifically through its N-terminal proline-rich region to both Insulin-like growth factor (IGF)-II and IGF-1R.	Proline	76-83	insulin like growth factor 1 receptor	Homo sapiens	144-150
18566390-1	2008	Engagement of peptide-MHC by the TCR induces a conformational change in CD3epsilon that exposes a proline-rich sequence (PRS) and recruits the cytoskeletal adaptor Nck.	Proline	98-105	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	72-82
18577755-2	2008	Recently, in work by Ferreon and Hilser, the energetics associated with Ala and Gly substitutions at a surface exposed proline site were determined calorimetrically by measuring the binding energetics of Sos peptide variants to the C-terminal Src Homology 3 domain of SEM-5.	Proline	119-126	xylosyltransferase 2	Homo sapiens	204-207
18175163-4	2008	The TNNI3 alteration, replacing proline with serine (Pro82Ser), has been previously implicated in elderly-onset hypertrophic cardiomyopathy, although its pathogenicity is not clear.	Proline	32-39	troponin I3, cardiac type	Homo sapiens	4-9
18214967-4	2008	On the other hand, the first residue significantly influencing the kinetics of muscle FBPase is proline 5.	Proline	96-103	fructose-bisphosphatase 2	Homo sapiens	79-92
18450748-5	2008	Pro(434) located in the TIR domain and the C-terminal region, with the exception of the RIP homotypic-interacting motif, were determinants of TICAM-1 oligomerization.	Proline	0-3	TIR domain containing adaptor molecule 1	Homo sapiens	142-149
18587493-5	2008	Sequencing of the candidate genes showed a heterozygous c.262C&gt;A change in the gene for connexin 50 (GJA8), which is localized at 1q21, that resulted in the replacement of a highly conserved proline by glutamine (p.P88Q).	Proline	194-201	gap junction protein alpha 8	Homo sapiens	91-102
18413140-2	2008	VASP is recruited to sites of actin dynamics by interactions with proline rich FPPPPP motifs.	Proline	66-73	vasodilator stimulated phosphoprotein	Homo sapiens	0-4
18498250-1	2008	The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a critical regulator of vertebrate development.	Proline	9-16	hematopoietically expressed homeobox	Homo sapiens	50-53
18498250-1	2008	The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a critical regulator of vertebrate development.	Proline	9-16	hematopoietically expressed homeobox	Homo sapiens	84-92
18587493-5	2008	Sequencing of the candidate genes showed a heterozygous c.262C&gt;A change in the gene for connexin 50 (GJA8), which is localized at 1q21, that resulted in the replacement of a highly conserved proline by glutamine (p.P88Q).	Proline	194-201	gap junction protein alpha 8	Homo sapiens	104-108
18348141-1	2008	In vitro studies suggest that p53 codon 72 genotype alters the apoptotic capacity of p53 protein, with the 72 arginine (R) form of wild-type p53 harboring a greater apoptosis-inducing potential than the 72 proline (P) variant.	Proline	206-213	tumor protein p53	Homo sapiens	30-33
18627291-5	2008	Our approach allowed monitoring of pro-KLK6 conversion to its active enzyme species and demonstrated that up to 5% of immunoreactive KLK6 detected in clinical samples represents active enzyme.	Proline	6-9	kallikrein related peptidase 6	Homo sapiens	39-43
18348141-1	2008	In vitro studies suggest that p53 codon 72 genotype alters the apoptotic capacity of p53 protein, with the 72 arginine (R) form of wild-type p53 harboring a greater apoptosis-inducing potential than the 72 proline (P) variant.	Proline	206-213	tumor protein p53	Homo sapiens	85-88
18348141-1	2008	In vitro studies suggest that p53 codon 72 genotype alters the apoptotic capacity of p53 protein, with the 72 arginine (R) form of wild-type p53 harboring a greater apoptosis-inducing potential than the 72 proline (P) variant.	Proline	206-213	tumor protein p53	Homo sapiens	85-88
18385132-4	2008	The majority of the alpha-helical repeats in human apoA-I are proline-punctuated.	Proline	62-69	apolipoprotein A1	Homo sapiens	51-57
18385132-6	2008	In this study we ask whether the substitution of a proline-containing sequence (PCS) separating other helices in human apoA-I for the non-proline-containing sequence (NPCS) between helices 7 and 8 (residues 184-190) influences HDL subclass association.	Proline	51-58	apolipoprotein A1	Homo sapiens	119-125
18359295-7	2008	By point mutating each individual Ser/Thr-Pro motif in c-Myb as well as by using deletion mutants we show that S528 in the EVES-motif was the docking site for Pin1.	Proline	42-45	MYB proto-oncogene, transcription factor	Homo sapiens	55-60
18359295-7	2008	By point mutating each individual Ser/Thr-Pro motif in c-Myb as well as by using deletion mutants we show that S528 in the EVES-motif was the docking site for Pin1.	Proline	42-45	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	159-163
18532879-1	2008	Proline-tyrosine nuclear localization signals (PY-NLSs) are recognized and transported into the nucleus by human Karyopherin (Kap) beta2/Transportin and yeast Kap104p.	Proline	0-7	transportin 1	Homo sapiens	113-136
18532879-1	2008	Proline-tyrosine nuclear localization signals (PY-NLSs) are recognized and transported into the nucleus by human Karyopherin (Kap) beta2/Transportin and yeast Kap104p.	Proline	0-7	Kap104p	Saccharomyces cerevisiae S288C	159-166
18385285-1	2008	The Kv1-4 families of K+ channels contain a tandem proline motif (PXP) in the S6 helix that is crucial for channel gating.	Proline	51-58	potassium voltage-gated channel subfamily A member 4	Homo sapiens	4-9
18385285-2	2008	In human Kv1.5, replacing the first proline by an alanine resulted in a nonfunctional channel.	Proline	36-43	potassium voltage-gated channel subfamily A member 5	Homo sapiens	9-14
18627291-5	2008	Our approach allowed monitoring of pro-KLK6 conversion to its active enzyme species and demonstrated that up to 5% of immunoreactive KLK6 detected in clinical samples represents active enzyme.	Proline	6-9	kallikrein related peptidase 6	Homo sapiens	133-137
18331837-2	2008	In 2 severely affected patients, IDS missense mutations, c.1016T&gt;C (novel) and c.1016T&gt;G (known) were identified predicting the substitution of an ambivalent cyclic proline and a hydrophilic arginine respectively for the hydrophobic leucine at residue 339.	Proline	171-178	iduronate 2-sulfatase	Homo sapiens	33-36
18390844-7	2008	Multivariate analysis for the presence of HCC revealed that the odds ratio (OR) for MDM2 G/G over T/T was 4.89 (P &lt; 0.001) and that of p53 Pro/Pro over Arg/Arg was 3.03 (P = 0.006).	Proline	142-145	tumor protein p53	Homo sapiens	138-141
18339708-10	2008	Glu and all other charged amino acids or Pro at position 59 also yielded nonfunctional NIS proteins.	Proline	41-44	solute carrier family 5 member 5	Homo sapiens	87-90
18322662-2	2008	Sequencing of the FLNB gene resulted in identification of a novel, de novo 508G>C point mutation resulting in substitution of proline for a highly conserved alanine (A170P).	Proline	126-133	filamin B	Homo sapiens	18-22
18420197-8	2008	ET-1 increased the [3H] proline uptake in LC cells suggesting that ET-1 contributed to an increase in total collagen synthesis in LC cells.	Proline	24-31	endothelin 1	Homo sapiens	0-4
18420197-8	2008	ET-1 increased the [3H] proline uptake in LC cells suggesting that ET-1 contributed to an increase in total collagen synthesis in LC cells.	Proline	24-31	endothelin 1	Homo sapiens	67-71
18716373-12	2008	Overexpression of CTGF by pcDNA3.1(+)/CTGF increased [(3)H]proline incorporation in cultured AFs.	Proline	59-66	cellular communication network factor 2	Rattus norvegicus	18-22
18373682-1	2008	We previously discovered that the budding yeast Saccharomyces cerevisiae Sigma1278b has the MPR1 gene that confers resistance to the proline analogue azetidine-2-carboxylate (AZC).	Proline	133-140	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	92-96
23495778-1	2008	BACKGROUND: The dipeptidyl peptidase-IV (DPP-IV) family has outgrown its humble origins as a simple enzymatic activity cleaving dipeptides from peptides with an accessible N-terminal penultimate proline with no clear role in metabolism.	Proline	195-202	dipeptidyl peptidase 4	Homo sapiens	16-39
23495778-1	2008	BACKGROUND: The dipeptidyl peptidase-IV (DPP-IV) family has outgrown its humble origins as a simple enzymatic activity cleaving dipeptides from peptides with an accessible N-terminal penultimate proline with no clear role in metabolism.	Proline	195-202	dipeptidyl peptidase 4	Homo sapiens	41-47
18716373-12	2008	Overexpression of CTGF by pcDNA3.1(+)/CTGF increased [(3)H]proline incorporation in cultured AFs.	Proline	59-66	cellular communication network factor 2	Rattus norvegicus	38-42
18076038-6	2008	Second, the proline-rich segment of SF3b155, following betaA, closely approaches p14.	Proline	12-19	splicing factor 3b subunit 1	Homo sapiens	36-43
18208544-4	2008	In contrast, isoforms containing an additional exon (exon 2), which is located within a proline-rich N-terminal region, have a greatly reduced ability to enhance nAChR maturation.	Proline	88-95	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	162-167
18076038-6	2008	Second, the proline-rich segment of SF3b155, following betaA, closely approaches p14.	Proline	12-19	ribonuclease P/MRP subunit p14	Homo sapiens	81-84
18362150-0	2008	Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87).	Proline	14-21	aralkylamine N-acetyltransferase	Homo sapiens	61-95
17920727-5	2008	Exogenous application of proline or glycinebetaine resulted in a reduction of protein carbonylation, and in an increase in glutathione redox state and activity of glutathione peroxidase, glutathione-S-transferase and glyoxalase I under salt stress.	Proline	25-32	glutathione S-transferase	Nicotiana tabacum	187-212
18453587-3	2008	Previously, our laboratory reported that soluble gp120 activates multiple protein kinases in primary human monocyte-derived macrophages, including the Src family kinase Lyn, PI3K, and the focal adhesion-related proline-rich tyrosine kinase Pyk2.	Proline	211-218	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	49-54
18445682-5	2008	A second region at the N-terminus of BNIPXL also targets the proline-rich region of Lbc.	Proline	61-68	prune homolog 2 with BCH domain	Homo sapiens	37-43
18477395-3	2008	Intriguingly, the deletion of the C-terminal proline-rich region of ALIX prevented detectable binding to p6.	Proline	45-52	programmed cell death 6 interacting protein	Homo sapiens	68-72
18477395-4	2008	In contrast, a four-amino acid deletion in the central hinge region of p6 increased its association with ALIX as shown by its ability to bind to ALIX lacking the proline rich domain.	Proline	162-169	programmed cell death 6 interacting protein	Homo sapiens	105-109
18477395-7	2008	Altogether, our data support a model where the C-terminal proline-rich domain of ALIX allows the access of its binding site to p6 by alleviating a conformational constraint resulting from the presence of the central p6 hinge.	Proline	58-65	programmed cell death 6 interacting protein	Homo sapiens	81-85
18059340-3	2008	Here, we demonstrate for the first time that apoptin interacts with the SH3 domain of p85, the regulatory subunit of phosphoinositide 3-kinase (PI3-K), through its proline-rich region.	Proline	164-171	APOPTIN;hypothetical protein;nucleocapsid protein	Chicken anemia virus	45-52
18059340-3	2008	Here, we demonstrate for the first time that apoptin interacts with the SH3 domain of p85, the regulatory subunit of phosphoinositide 3-kinase (PI3-K), through its proline-rich region.	Proline	164-171	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	86-89
18059340-3	2008	Here, we demonstrate for the first time that apoptin interacts with the SH3 domain of p85, the regulatory subunit of phosphoinositide 3-kinase (PI3-K), through its proline-rich region.	Proline	164-171	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	117-142
18059340-4	2008	Apoptin derivatives devoid of this proline-rich region do not interact with p85, are unable to activate PI3-K, and show impaired apoptosis induction.	Proline	35-42	APOPTIN;hypothetical protein;nucleocapsid protein	Chicken anemia virus	0-7
18059340-5	2008	Moreover, apoptin mutants containing the proline-rich domain are sufficient to elevate PI3-K activity and to induce apoptosis in cancer cells.	Proline	41-48	APOPTIN;hypothetical protein;nucleocapsid protein	Chicken anemia virus	10-17
18458157-3	2008	Previous studies found that a fraction of human proline-directed phosphatase Cdc14B associates with centrosomes.	Proline	48-55	cell division cycle 14B	Homo sapiens	77-83
18509027-9	2008	Mutation of Pro(330) and Pro(334) abolished the effects of hBest1 on Ca(V)1.3.	Proline	12-15	bestrophin 1	Homo sapiens	59-65
18509027-9	2008	Mutation of Pro(330) and Pro(334) abolished the effects of hBest1 on Ca(V)1.3.	Proline	12-15	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	69-77
18509027-9	2008	Mutation of Pro(330) and Pro(334) abolished the effects of hBest1 on Ca(V)1.3.	Proline	25-28	bestrophin 1	Homo sapiens	59-65
18509027-9	2008	Mutation of Pro(330) and Pro(334) abolished the effects of hBest1 on Ca(V)1.3.	Proline	25-28	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	69-77
18369157-0	2008	Proline and gamma-carboxylated glutamate residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4.	Proline	0-7	matrix Gla protein	Danio rerio	53-71
18369157-0	2008	Proline and gamma-carboxylated glutamate residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4.	Proline	0-7	bone morphogenetic protein 4	Danio rerio	100-128
18351334-9	2008	It appears that the elevated proline levels are due primarily to an increase in proline uptake from a nutrient medium caused by the induction of PUT4.	Proline	29-36	proline permease PUT4	Saccharomyces cerevisiae S288C	145-149
18351334-9	2008	It appears that the elevated proline levels are due primarily to an increase in proline uptake from a nutrient medium caused by the induction of PUT4.	Proline	80-87	proline permease PUT4	Saccharomyces cerevisiae S288C	145-149
18042412-3	2008	This c.548T>C mutation converts a leucine to a proline residue at position 183 in the alpha2-helix of the HFE-protein (Leu183Pro).	Proline	47-54	homeostatic iron regulator	Homo sapiens	106-109
18215127-8	2008	Docking showed the major component of the interaction site on AChE to be the acidic sequence Arg(90)-Glu-Leu-Ser-Glu-Asp(95) on the omega loop, and also the involvement of Pro(40)-Pro-Val(42), Arg(46) (linked to Glu(94) by a salt bridge) and the hexapeptide Asp(61)-Ala-Thr-Thr-Phe-Gln(66).	Proline	172-175	acetylcholinesterase	Mus musculus	62-66
18037962-0	2008	The proline-rich domain in p63 is necessary for the transcriptional and apoptosis-inducing activities of TAp63.	Proline	4-11	tumor protein p63	Homo sapiens	27-30
18183483-1	2008	The proline-directed serine threonine kinase, Cdk5, is an unusual molecule that belongs to the well-known large family of proteins, cyclin-dependent kinases (Cdks).	Proline	4-11	cyclin dependent kinase 5	Homo sapiens	46-50
18183483-1	2008	The proline-directed serine threonine kinase, Cdk5, is an unusual molecule that belongs to the well-known large family of proteins, cyclin-dependent kinases (Cdks).	Proline	4-11	cyclin dependent kinase 2	Homo sapiens	158-162
18384376-6	2008	Mutational analysis of 4E-BP1 reveals that isoleucine is a key feature of the RAIP motif, that proline is also very important and that there is greater tolerance for substitution of the first two residues.	Proline	95-102	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	23-29
18440561-3	2008	For therapeutic angiogenesis purposes, HIF-1 alpha stabilization was previously achieved by either deleting its oxygen-dependent degradation domains, or introducing two proline point mutations at residues P402 and P564.	Proline	169-176	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-50
19123984-3	2008	Under normoxia, HIF-1 alpha is hydroxylated on prolines 402 and 564 and is targeted for ubiquitin-mediated degradation by interacting with the von Hippel-Lindau protein complex (pVHL).	Proline	47-55	hypoxia inducible factor 1, alpha subunit	Mus musculus	16-27
18408722-0	2008	The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes.	Proline	4-11	CD3 antigen, epsilon polypeptide	Mus musculus	29-39
18408722-0	2008	The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes.	Proline	4-11	CD4 antigen	Mus musculus	125-128
18408722-1	2008	Antigen recognition by T cell antigen receptors (TCRs) is thought to "unmask" a proline-rich sequence (PRS) present in the CD3epsilon cytosolic segment, which allows it to trigger T cell activation.	Proline	80-87	CD3 antigen, epsilon polypeptide	Mus musculus	123-133
18473735-3	2008	Specifically, Pin1 controls the conversion of peptidyl proline bond conversion from cis to trans, only when the preceding serine or threonine is phosphorylated.	Proline	55-62	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	14-18
18508601-2	2008	Both protein kinases can bind to p38alpha MAPK and are activated by p38alpha via multiple proline-directed phosphorylations in a stress-dependent manner.	Proline	90-97	mitogen-activated protein kinase 14	Mus musculus	33-41
18508601-2	2008	Both protein kinases can bind to p38alpha MAPK and are activated by p38alpha via multiple proline-directed phosphorylations in a stress-dependent manner.	Proline	90-97	mitogen-activated protein kinase 14	Mus musculus	68-76
18508601-4	2008	Functional differences between MK2 and MK3 could result from the more prominent proline-rich SH3-targeting region in MK2, but are not reported so far.	Proline	80-87	MAP kinase-activated protein kinase 2	Mus musculus	31-34
18508601-4	2008	Functional differences between MK2 and MK3 could result from the more prominent proline-rich SH3-targeting region in MK2, but are not reported so far.	Proline	80-87	mitogen-activated protein kinase-activated protein kinase 3	Mus musculus	39-42
18508601-4	2008	Functional differences between MK2 and MK3 could result from the more prominent proline-rich SH3-targeting region in MK2, but are not reported so far.	Proline	80-87	MAP kinase-activated protein kinase 2	Mus musculus	117-120
18281297-1	2008	PNRC (proline-rich nuclear receptor co-activator) was previously identified using bovine SF-1 (steroidogenic factor 1) as the bait in a yeast two-hybrid screening of a human mammary gland cDNA expression library.	Proline	6-13	nuclear receptor subfamily 5 group A member 1	Bos taurus	89-117
18355840-9	2008	In p53 codon72 Arg/Pro + Pro/Pro carriers the frequency of the AG + GG genotype of MSH3 exon23 was significantly increased in patients compared to controls (OR 2.1, 95% CI 1.05-4.34).	Proline	19-22	tumor protein p53	Homo sapiens	3-6
18355840-9	2008	In p53 codon72 Arg/Pro + Pro/Pro carriers the frequency of the AG + GG genotype of MSH3 exon23 was significantly increased in patients compared to controls (OR 2.1, 95% CI 1.05-4.34).	Proline	19-22	mutS homolog 3	Homo sapiens	83-87
18355840-9	2008	In p53 codon72 Arg/Pro + Pro/Pro carriers the frequency of the AG + GG genotype of MSH3 exon23 was significantly increased in patients compared to controls (OR 2.1, 95% CI 1.05-4.34).	Proline	25-28	tumor protein p53	Homo sapiens	3-6
18355840-9	2008	In p53 codon72 Arg/Pro + Pro/Pro carriers the frequency of the AG + GG genotype of MSH3 exon23 was significantly increased in patients compared to controls (OR 2.1, 95% CI 1.05-4.34).	Proline	25-28	mutS homolog 3	Homo sapiens	83-87
18355840-9	2008	In p53 codon72 Arg/Pro + Pro/Pro carriers the frequency of the AG + GG genotype of MSH3 exon23 was significantly increased in patients compared to controls (OR 2.1, 95% CI 1.05-4.34).	Proline	25-28	tumor protein p53	Homo sapiens	3-6
18355840-9	2008	In p53 codon72 Arg/Pro + Pro/Pro carriers the frequency of the AG + GG genotype of MSH3 exon23 was significantly increased in patients compared to controls (OR 2.1, 95% CI 1.05-4.34).	Proline	25-28	mutS homolog 3	Homo sapiens	83-87
18505929-1	2008	PELP1 (proline-rich, glutamic acid-rich, and leucine-rich protein-1) is a potential proto-oncogene that functions as a coregulator of estrogen receptor (ER), and its expression is deregulated during breast cancer progression.	Proline	7-14	proline, glutamate and leucine rich protein 1	Homo sapiens	0-5
18505929-1	2008	PELP1 (proline-rich, glutamic acid-rich, and leucine-rich protein-1) is a potential proto-oncogene that functions as a coregulator of estrogen receptor (ER), and its expression is deregulated during breast cancer progression.	Proline	7-14	estrogen receptor 1	Homo sapiens	134-151
18505929-1	2008	PELP1 (proline-rich, glutamic acid-rich, and leucine-rich protein-1) is a potential proto-oncogene that functions as a coregulator of estrogen receptor (ER), and its expression is deregulated during breast cancer progression.	Proline	7-14	estrogen receptor 1	Homo sapiens	153-155
18037962-12	2008	Altogether, our findings suggest that TAp63 transcriptional activity can be regulated by modification(s) of, or protein interactions with, the p63 proline-rich domain.	Proline	147-154	tumor protein p63	Homo sapiens	40-43
18207213-5	2008	Mutation of prolines surrounding the peptide phosphoacceptor site reduced phosphorylation by HSV-2 UL13, and a peptide containing serine-proline amid alanines and glycines was phosphorylated.	Proline	12-20	involved in protein phosphorylation	Human alphaherpesvirus 2	99-103
18423915-4	2008	A G-to-C SNP at p53 codon 72 results in an Arg/Pro polymorphism, which is associated with apoptosis induction potential and p53 mutation status.	Proline	47-50	tumor protein p53	Homo sapiens	16-19
18423915-4	2008	A G-to-C SNP at p53 codon 72 results in an Arg/Pro polymorphism, which is associated with apoptosis induction potential and p53 mutation status.	Proline	47-50	tumor protein p53	Homo sapiens	124-127
17723252-7	2008	It was also noteworthy that, despite highly accumulating proline, the A. thaliana eskimo-1 mutant was the most salt-sensitive species.	Proline	57-64	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	82-90
17998932-1	2008	Codon 72 of human p53 gene is polymorphic, encoding arginine or proline.	Proline	64-71	tumor protein p53	Homo sapiens	18-21
18336795-0	2008	Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter.	Proline	8-15	ATP binding cassette subfamily B member 1	Homo sapiens	124-128
18287100-4	2008	The first steps in the degradation of proline and hydroxyproline are catalyzed by proline oxidase (POX) and hydroxyproline oxidase (OH-POX), respectively.	Proline	38-45	proline dehydrogenase 1	Homo sapiens	99-102
18287100-4	2008	The first steps in the degradation of proline and hydroxyproline are catalyzed by proline oxidase (POX) and hydroxyproline oxidase (OH-POX), respectively.	Proline	38-45	proline dehydrogenase 1	Homo sapiens	135-138
18276589-8	2008	The tetramers and dimers containing recombinant PHY-4.1 had a distinct substrate specificity from the other C-P4Hs in that they hydroxylated poly(l-proline) and certain other proline-rich peptides, including ones that are expressed in the pharynx, in addition to collagen-like peptides.	Proline	148-155	Fe2OG dioxygenase domain-containing protein	Caenorhabditis elegans	48-53
18276589-9	2008	These data and the observed restricted expression of the phy-4.1 transcript and PHY-4.1 polypeptide in the pharyngeal gland cells and the excretory duct suggest that in addition to collagens, PHY-4.1 may hydroxylate additional proline-rich proteins in vivo.	Proline	227-234	Fe2OG dioxygenase domain-containing protein	Caenorhabditis elegans	57-62
18076380-0	2008	Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers.	Proline	13-20	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	0-12
18076380-5	2008	BChE in the neuromuscular junctions and the central nervous system is anchored to membranes through interactions with ColQ (AChE-associated collagen tail protein) and PRiMA (proline-rich membrane anchor) proteins containing proline-rich domains.	Proline	174-181	butyrylcholinesterase	Homo sapiens	0-4
18076380-6	2008	BChE prepared in cell culture is primarily monomeric, unless expressed in the presence of proline-rich peptides.	Proline	90-97	butyrylcholinesterase	Homo sapiens	0-4
18076380-8	2008	We found that a series of proline-rich peptides was released from denatured human and horse plasma BChE.	Proline	26-33	butyrylcholinesterase	Equus caballus	99-103
18076380-12	2008	A proline-rich peptide of 17 amino acids derived from lamellipodin drove the assembly of human BChE secreted from CHO (Chinese-hamster ovary) cells into tetramers.	Proline	2-9	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	54-66
18076380-12	2008	A proline-rich peptide of 17 amino acids derived from lamellipodin drove the assembly of human BChE secreted from CHO (Chinese-hamster ovary) cells into tetramers.	Proline	2-9	butyrylcholinesterase	Homo sapiens	95-99
18076380-13	2008	We propose that the proline-rich peptides organize the 4 subunits of BChE into a 340 kDa tetramer, by interacting with the C-terminal BChE tetramerization domain.	Proline	20-27	butyrylcholinesterase	Homo sapiens	69-73
18076380-13	2008	We propose that the proline-rich peptides organize the 4 subunits of BChE into a 340 kDa tetramer, by interacting with the C-terminal BChE tetramerization domain.	Proline	20-27	butyrylcholinesterase	Homo sapiens	134-138
18336795-0	2008	Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter.	Proline	8-15	ATP binding cassette subfamily C member 1	Homo sapiens	130-135
18324760-4	2008	A model of interaction between one inhibitor of this series and ACE2 suggests that the critical role played by a proline in inhibitors, but also for substrates hydrolysis, may rely on the presence of Tyr (510) in the ACE2 active site.	Proline	113-120	angiotensin converting enzyme 2	Homo sapiens	64-68
18252715-6	2008	The kinase domain of ILK, including proline-rich regions, appeared to interact physically with the Src homology 3 domain of c-Src.	Proline	36-43	integrin-linked kinase	Rattus norvegicus	21-24
18252715-6	2008	The kinase domain of ILK, including proline-rich regions, appeared to interact physically with the Src homology 3 domain of c-Src.	Proline	36-43	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	124-129
18201746-2	2008	We previously evaluated several HIV-2 isolates for their sensitivity to cynomolgus monkey (CM) TRIM5alpha, an anti-HIV factor in OWM cells, and found that viruses carrying proline at the 120th position of the capsid protein were sensitive to CM TRIM5alpha, whereas those with either alanine or glutamine were resistant.	Proline	172-179	tripartite motif-containing protein 5	Macaca fascicularis	95-105
18201746-2	2008	We previously evaluated several HIV-2 isolates for their sensitivity to cynomolgus monkey (CM) TRIM5alpha, an anti-HIV factor in OWM cells, and found that viruses carrying proline at the 120th position of the capsid protein were sensitive to CM TRIM5alpha, whereas those with either alanine or glutamine were resistant.	Proline	172-179	tripartite motif-containing protein 5	Macaca fascicularis	245-255
18324760-4	2008	A model of interaction between one inhibitor of this series and ACE2 suggests that the critical role played by a proline in inhibitors, but also for substrates hydrolysis, may rely on the presence of Tyr (510) in the ACE2 active site.	Proline	113-120	angiotensin converting enzyme 2	Homo sapiens	217-221
18294929-5	2008	Protein sequencing of a truncated partially calpain-digested OGG1 revealed that calpain recognizes OGG1 for degradation at a putative PEST (proline, glutamic acid, serine, threonine) sequence in the C-terminus of the enzyme.	Proline	140-147	8-oxoguanine DNA glycosylase	Homo sapiens	61-65
18386881-2	2008	When both beta (2)-homo amino acid- and beta (3)-homo amino acid substitutions were used, allowed the identification of H-( R)beta (2)hVal-Tyr-Ile-His-Pro-beta (3)hPhe-OH as a potent and stable Ang IV analog with high selectivity for IRAP versus AP-N and the AT1 receptor.	Proline	151-154	ArfGAP with FG repeats 1	Homo sapiens	120-130
18386881-2	2008	When both beta (2)-homo amino acid- and beta (3)-homo amino acid substitutions were used, allowed the identification of H-( R)beta (2)hVal-Tyr-Ile-His-Pro-beta (3)hPhe-OH as a potent and stable Ang IV analog with high selectivity for IRAP versus AP-N and the AT1 receptor.	Proline	151-154	leucyl and cystinyl aminopeptidase	Homo sapiens	234-238
18386881-2	2008	When both beta (2)-homo amino acid- and beta (3)-homo amino acid substitutions were used, allowed the identification of H-( R)beta (2)hVal-Tyr-Ile-His-Pro-beta (3)hPhe-OH as a potent and stable Ang IV analog with high selectivity for IRAP versus AP-N and the AT1 receptor.	Proline	151-154	alanyl aminopeptidase, membrane	Homo sapiens	246-250
18250167-3	2008	Here, we report a novel K(ATP) channel gating defect caused by CHI-associated Kir6.2 mutations at arginine 301 (to cysteine, glycine, histidine, or proline).	Proline	148-155	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	78-84
18294929-5	2008	Protein sequencing of a truncated partially calpain-digested OGG1 revealed that calpain recognizes OGG1 for degradation at a putative PEST (proline, glutamic acid, serine, threonine) sequence in the C-terminus of the enzyme.	Proline	140-147	8-oxoguanine DNA glycosylase	Homo sapiens	99-103
18215142-0	2008	The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning.	Proline	29-36	tumor protein p53	Homo sapiens	77-80
18215142-0	2008	The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning.	Proline	29-36	tumor protein p53	Homo sapiens	141-144
18259764-5	2008	After summarizing the reported cases with ATP2C1 mutation, we concluded that the T1004C transition resulted in a novel missense mutation of leucine condon (CTG) to proline (CCG) at amino acid residue 335(L335P) in hSPCA1.	Proline	164-171	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	42-48
18259764-5	2008	After summarizing the reported cases with ATP2C1 mutation, we concluded that the T1004C transition resulted in a novel missense mutation of leucine condon (CTG) to proline (CCG) at amino acid residue 335(L335P) in hSPCA1.	Proline	164-171	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	214-220
18215142-4	2008	In the present study, using phage display, sitedirected mutagenesis, pulldown and immunoprecipitation assays we localized the site of FAK binding to a 7-amino-acid region(amino acids 65-71) in the N-terminal proline-rich domain of human p53.	Proline	208-215	protein tyrosine kinase 2	Homo sapiens	134-137
18215142-0	2008	The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning.	Proline	29-36	protein tyrosine kinase 2	Homo sapiens	117-120
18215142-4	2008	In the present study, using phage display, sitedirected mutagenesis, pulldown and immunoprecipitation assays we localized the site of FAK binding to a 7-amino-acid region(amino acids 65-71) in the N-terminal proline-rich domain of human p53.	Proline	208-215	tumor protein p53	Homo sapiens	237-240
18230330-6	2008	His-55 was found to be essential for the catalytic activity of hPAT1 because the corresponding mutants H55A, H55N and H55E had no detectable l-proline transport activity.	Proline	141-150	solute carrier family 36 member 1	Homo sapiens	63-68
18327588-4	2008	Myr1 is characterized by a coiled coil region and a GYF domain, a protein module binding proline-rich sequences.	Proline	89-96	Syh1p	Saccharomyces cerevisiae S288C	0-4
18414047-8	2008	An association has been reported between women carrying the p53 codon 72 polymorphism (a proline to arginine change) with recurrent implantation failure, suggesting a similar function for p53 in humans.	Proline	89-96	tumor protein p53	Homo sapiens	60-63
18414047-8	2008	An association has been reported between women carrying the p53 codon 72 polymorphism (a proline to arginine change) with recurrent implantation failure, suggesting a similar function for p53 in humans.	Proline	89-96	tumor protein p53	Homo sapiens	188-191
18157855-5	2008	Overexpression of prolidase in some neoplastic cells suggests that the proline analogue of alkylating agents may serve as a prolidase convertible prodrugs.	Proline	71-78	peptidase D	Homo sapiens	18-27
18157855-5	2008	Overexpression of prolidase in some neoplastic cells suggests that the proline analogue of alkylating agents may serve as a prolidase convertible prodrugs.	Proline	71-78	peptidase D	Homo sapiens	124-133
18272203-2	2008	In humans, we recently found that a TP53 codon 72 Arginine (Arg) to Proline (Pro) polymorphism affected both cancer incidence and longevity as well.	Proline	68-75	tumor protein p53	Homo sapiens	36-40
18342853-6	2008	We found a significant association of the allele Gly-637 (GGC) (p=0.00004, OR=27.30, CI=3.87-548.04) and the genotypes Asp-637/Gly-637 (p=0.01, OR=16.0, CI=2.19-631.21), Pro-661/Pro-661 (p=0.006, OR=11.30, CI=2.28-75.77) with HP.	Proline	170-173	gamma-glutamylcyclotransferase	Homo sapiens	58-61
18342853-6	2008	We found a significant association of the allele Gly-637 (GGC) (p=0.00004, OR=27.30, CI=3.87-548.04) and the genotypes Asp-637/Gly-637 (p=0.01, OR=16.0, CI=2.19-631.21), Pro-661/Pro-661 (p=0.006, OR=11.30, CI=2.28-75.77) with HP.	Proline	178-181	gamma-glutamylcyclotransferase	Homo sapiens	58-61
18228599-4	2008	Mutation analysis of the POU4F3 gene in 30 patients suffering from dominantly inherited hearing impairment revealed a second novel missense mutation (c.668T&gt;C), resulting in the substitution of a proline for a leucine residue (p.L223P) within the POU-specific DNA-binding domain of the protein.	Proline	199-206	POU class 4 homeobox 3	Homo sapiens	25-31
23105736-1	2008	Currently available method(s) for assaying pyrroline-5-carboxylate (P5C), an important intermediate metabolite of ornithine, proline and glutamate metabolic pathways, are cumbersome or not sensitive enough for microanalysis.	Proline	125-132	pyrroline-5-carboxylate reductase 1	Homo sapiens	68-71
18343828-5	2008	Seven candidate BGLF4 target sites were predicted within a proline-rich region between the DNA-processivity and nuclear-localization domains of BMRF1.	Proline	59-66	BMRF1	Human gammaherpesvirus 4	144-149
18343849-8	2008	Unexpectedly, insertion of IL-13 in the proline-rich region showed evidence of initiation of fusion and fusion-peptide exposure, but fusion was blocked at a subsequent step prior to fusion-pore formation.	Proline	40-47	interleukin 13	Homo sapiens	27-32
18272203-2	2008	In humans, we recently found that a TP53 codon 72 Arginine (Arg) to Proline (Pro) polymorphism affected both cancer incidence and longevity as well.	Proline	68-71	tumor protein p53	Homo sapiens	36-40
18279888-2	2008	Shc comprises an N-terminal phosphotyrosine binding (PTB) domain, a C-terminal Src homology 2 (SH2) domain and a central proline-rich collagen homology 1 domain.	Proline	121-128	SHC adaptor protein 1	Homo sapiens	0-3
18285459-3	2008	A hydroxylated proline 1465 within an LXXLAP motif located N-terminal to the CTD allows the interaction of Rpb1 with pVHL.	Proline	15-22	RNA polymerase II subunit A	Homo sapiens	107-111
18285459-3	2008	A hydroxylated proline 1465 within an LXXLAP motif located N-terminal to the CTD allows the interaction of Rpb1 with pVHL.	Proline	15-22	von Hippel-Lindau tumor suppressor	Homo sapiens	117-121
18182016-6	2008	In transgenic S. commersonii, AtCBF1 activity also mimicked cold treatment by increasing proline and total sugar contents in the absence of cold.	Proline	89-96	C-repeat/DRE binding factor 1	Arabidopsis thaliana	30-36
18325784-7	2008	Finally, modeling studies showed that the PP1 docking motif of PNUTS fits into the binding pocket on the enzyme surface, despite a C-terminal adjacent proline.	Proline	151-158	neuropeptide Y receptor Y4	Homo sapiens	42-45
18325784-7	2008	Finally, modeling studies showed that the PP1 docking motif of PNUTS fits into the binding pocket on the enzyme surface, despite a C-terminal adjacent proline.	Proline	151-158	protein phosphatase 1 regulatory subunit 10	Homo sapiens	63-68
17906699-3	2008	We report here that proline-rich tyrosine kinase Pyk2 is highly expressed in SCLC cells and provides a functional link between neuropeptide-induced increases in [Ca2+](i) and tumor cell proliferation.	Proline	20-27	protein tyrosine kinase 2 beta	Homo sapiens	49-53
18388733-3	2008	Cyclin-dependent kinase 5 (Cdk5) is a postmitotic proline-directed serine/threonine kinase that hyperphosphorylates tau under pathological conditions.	Proline	50-57	cyclin dependent kinase 5	Homo sapiens	0-25
18388733-3	2008	Cyclin-dependent kinase 5 (Cdk5) is a postmitotic proline-directed serine/threonine kinase that hyperphosphorylates tau under pathological conditions.	Proline	50-57	cyclin dependent kinase 5	Homo sapiens	27-31
18332426-7	2008	In contrast, loss of function of a mutant TSHR (Pro --&gt; Leu at 556) in congenital hypothyroid mice activates osteoclast differentiation, confirming once again our premise that TSHRs have a critical role in regulating bone remodeling.	Proline	48-51	thyroid stimulating hormone receptor	Mus musculus	42-46
18234212-9	2008	The resulting thermodynamic magnitudes classify the different proline residues according to their importance in the interaction as P2 approximately P7 approximately P10&gt;P9 approximately P6&gt;P8, which agrees well with Lim"s model for the interaction between SH3 domains and proline-rich peptides.	Proline	62-69	S100 calcium binding protein A10	Homo sapiens	165-168
18234212-9	2008	The resulting thermodynamic magnitudes classify the different proline residues according to their importance in the interaction as P2 approximately P7 approximately P10&gt;P9 approximately P6&gt;P8, which agrees well with Lim"s model for the interaction between SH3 domains and proline-rich peptides.	Proline	278-285	S100 calcium binding protein A10	Homo sapiens	165-168
18288105-5	2008	Here we show that acetaldehyde is a powerful nucleophile in asymmetric, proline-catalysed Mannich reactions with N-tert-butoxycarbonyl (N-Boc)-imines, yielding beta-amino aldehydes with extremely high enantioselectivities-desirable products as drug intermediates and in the synthesis of other biologically active molecules.	Proline	72-79	BOC cell adhesion associated, oncogene regulated	Homo sapiens	138-141
18242161-2	2008	The AhR has a transactivation domain comprised of proline/serine/threonine-rich, glutamine-rich, and acidic amino acid subdomains.	Proline	50-57	aryl hydrocarbon receptor	Homo sapiens	4-7
18325888-4	2008	We report here that one variant of CD1e with a proline at position 194, encoded by allele 4, does not assist PIM(6) presentation to CD1b-restricted specific T cells.	Proline	47-54	CD1e molecule	Homo sapiens	35-39
18174177-6	2008	A single proline mutation in the SH3 domain of PACSIN 3 abolishes its inhibitory effect on TRPV4, indicating that PACSIN 3 must bind to the channel to modulate its function.	Proline	9-16	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	47-55
18174177-6	2008	A single proline mutation in the SH3 domain of PACSIN 3 abolishes its inhibitory effect on TRPV4, indicating that PACSIN 3 must bind to the channel to modulate its function.	Proline	9-16	transient receptor potential cation channel subfamily V member 4	Homo sapiens	91-96
18190909-0	2008	Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed protein serine/threonine kinase essential for brain development and implicated in synaptic plasticity, dopaminergic neurotransmission, drug addiction, and neurodegenerative disorders.	Proline	116-123	cyclin-dependent kinase 5	Mus musculus	23-48
18174177-6	2008	A single proline mutation in the SH3 domain of PACSIN 3 abolishes its inhibitory effect on TRPV4, indicating that PACSIN 3 must bind to the channel to modulate its function.	Proline	9-16	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	114-122
18190909-0	2008	Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed protein serine/threonine kinase essential for brain development and implicated in synaptic plasticity, dopaminergic neurotransmission, drug addiction, and neurodegenerative disorders.	Proline	116-123	cyclin-dependent kinase 5	Mus musculus	78-103
18190909-0	2008	Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed protein serine/threonine kinase essential for brain development and implicated in synaptic plasticity, dopaminergic neurotransmission, drug addiction, and neurodegenerative disorders.	Proline	116-123	cyclin-dependent kinase 5	Mus musculus	105-109
18174177-7	2008	In line herewith, mutations at specific proline residues in the N terminus of TRPV4 abolish binding of PACSIN 3 and render the channel insensitive to PACSIN 3-induced inhibition.	Proline	40-47	transient receptor potential cation channel subfamily V member 4	Homo sapiens	78-83
18174177-7	2008	In line herewith, mutations at specific proline residues in the N terminus of TRPV4 abolish binding of PACSIN 3 and render the channel insensitive to PACSIN 3-induced inhibition.	Proline	40-47	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	103-111
17437319-1	2008	Nuclear receptor-binding SET-domain-containing protein 1 (NSD1), a culprit gene for Sotos syndrome, contains a su(var)3-9, enhancer-of-zeste, trithorax (SET) domain that is responsible for histone methyltransferase activity and other domains such as plant homeodomain (PHD) and proline-tryptophan-tryptophan-proline (PWWP) involved in protein-protein interactions in the C-terminal half of NSD1.	Proline	278-285	nuclear receptor-binding SET-domain protein 1	Mus musculus	0-56
18333624-1	2008	A recombinant cyclophilin A (CypA) mutant, which carries a serine instead of proline at sequence 16, was prepared for structural and functional assessment for human CypA.	Proline	77-84	peptidylprolyl isomerase A	Homo sapiens	14-27
18277153-1	2008	PURPOSE OF REVIEW: Studies of inherited conditions characterized by high or low blood pressure reveal the importance of a new signalling cascade, With no Lysine kinases (WNK) --&gt; ste20/SPS1-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive kinase-1 (OSR1) --&gt; Cation-Chloride Cotransporters (CCC), in regulating blood pressure and in the pathogenesis of essential hypertension.	Proline	201-208	serine/threonine kinase 24	Homo sapiens	182-187
18269246-4	2008	The 45-residue juxtamembrane domain of EGFR (JM), located between the transmembrane and kinase domains, regulates receptor activation and trafficking to the basolateral membrane of polarized epithelia through a proline-rich motif that resembles a consensus SH3 domain binding site.	Proline	211-218	epidermal growth factor receptor	Homo sapiens	39-43
17993503-2	2008	GADS possesses N- and C-terminal Src homology 3 (SH3) domains flanking a central Src homology 2 (SH2) domain and a 126-residue region rich in glutamine and proline residues, presumed to be largely unstructured.	Proline	156-163	GRB2 related adaptor protein 2	Homo sapiens	0-4
17994554-1	2008	The proline-rich N-terminal domain of gamma-zein has been reported in relevant processes, which include its ability to cross the cell membranes.	Proline	4-11	prolamin 50 kDa gamma zein	Zea mays	38-48
17975550-8	2008	We suggest, that the C-terminal domain of exon 1 Huntingtin, namely the proline rich domain, is responsible for mediating a neuroprotective effect against excitotoxicity.	Proline	72-79	huntingtin	Mus musculus	49-59
17437319-1	2008	Nuclear receptor-binding SET-domain-containing protein 1 (NSD1), a culprit gene for Sotos syndrome, contains a su(var)3-9, enhancer-of-zeste, trithorax (SET) domain that is responsible for histone methyltransferase activity and other domains such as plant homeodomain (PHD) and proline-tryptophan-tryptophan-proline (PWWP) involved in protein-protein interactions in the C-terminal half of NSD1.	Proline	278-285	nuclear receptor-binding SET-domain protein 1	Mus musculus	58-62
17437319-1	2008	Nuclear receptor-binding SET-domain-containing protein 1 (NSD1), a culprit gene for Sotos syndrome, contains a su(var)3-9, enhancer-of-zeste, trithorax (SET) domain that is responsible for histone methyltransferase activity and other domains such as plant homeodomain (PHD) and proline-tryptophan-tryptophan-proline (PWWP) involved in protein-protein interactions in the C-terminal half of NSD1.	Proline	278-285	nuclear receptor-binding SET-domain protein 1	Mus musculus	390-394
17437319-1	2008	Nuclear receptor-binding SET-domain-containing protein 1 (NSD1), a culprit gene for Sotos syndrome, contains a su(var)3-9, enhancer-of-zeste, trithorax (SET) domain that is responsible for histone methyltransferase activity and other domains such as plant homeodomain (PHD) and proline-tryptophan-tryptophan-proline (PWWP) involved in protein-protein interactions in the C-terminal half of NSD1.	Proline	308-315	nuclear receptor-binding SET-domain protein 1	Mus musculus	0-56
17437319-1	2008	Nuclear receptor-binding SET-domain-containing protein 1 (NSD1), a culprit gene for Sotos syndrome, contains a su(var)3-9, enhancer-of-zeste, trithorax (SET) domain that is responsible for histone methyltransferase activity and other domains such as plant homeodomain (PHD) and proline-tryptophan-tryptophan-proline (PWWP) involved in protein-protein interactions in the C-terminal half of NSD1.	Proline	308-315	nuclear receptor-binding SET-domain protein 1	Mus musculus	58-62
17437319-1	2008	Nuclear receptor-binding SET-domain-containing protein 1 (NSD1), a culprit gene for Sotos syndrome, contains a su(var)3-9, enhancer-of-zeste, trithorax (SET) domain that is responsible for histone methyltransferase activity and other domains such as plant homeodomain (PHD) and proline-tryptophan-tryptophan-proline (PWWP) involved in protein-protein interactions in the C-terminal half of NSD1.	Proline	308-315	nuclear receptor-binding SET-domain protein 1	Mus musculus	390-394
18393921-5	2008	However, as a consequence of reading-frame shifts due to nt insertions/deletions, the protein products generated may differ considerably from the prototypal HRB protein, which comprises one Arf-GAP zinc finger domain, several Phenylalanine-Glycine (FG) motifs and four Asparagine-Proline-Phenylalanine (NPF) motifs.	Proline	280-287	ArfGAP with FG repeats 1	Homo sapiens	157-160
18288414-2	2008	Several reports have focused on p53 polymorphisms as risk factors in lung cancer, in particular at codon 72 of exon 4, encoding either an arginine (Arg72R) or a proline (Pro72P) amino acid.	Proline	161-168	tumor protein p53	Homo sapiens	32-35
17588735-0	2008	Cell death signal by glycine- and proline-rich plant glycoprotein is transferred from cytochrome c and nuclear factor kappa B to caspase 3 in Hep3B cells.	Proline	34-41	cytochrome c, somatic	Homo sapiens	86-98
17588735-0	2008	Cell death signal by glycine- and proline-rich plant glycoprotein is transferred from cytochrome c and nuclear factor kappa B to caspase 3 in Hep3B cells.	Proline	34-41	caspase 3	Homo sapiens	129-138
18344614-0	2008	Novel functions of ubiquitin ligase HRD1 with transmembrane and proline-rich domains.	Proline	64-71	synoviolin 1	Homo sapiens	36-40
18344614-4	2008	Here, we show that the proline-rich domain of HRD1 is necessary to promote the degradation of Pael-R and that the protein"s transmembrane domain is necessary to transfer Pael-R from the endoplasmic reticulum (ER) to the cytosol.	Proline	23-30	synoviolin 1	Homo sapiens	46-50
18344614-4	2008	Here, we show that the proline-rich domain of HRD1 is necessary to promote the degradation of Pael-R and that the protein"s transmembrane domain is necessary to transfer Pael-R from the endoplasmic reticulum (ER) to the cytosol.	Proline	23-30	G protein-coupled receptor 37	Homo sapiens	94-100
18086875-1	2008	The Cdc42-like GTPase Wnt responsive Cdc42 homolog 1 (Wrch1) has several atypical features; it has an N-terminal proline-rich extension that confers binding to SH3 domains, and it harbors an extremely high intrinsic nucleotide exchange activity, which overrides the normal GTPase activity.	Proline	113-120	ras homolog family member U	Homo sapiens	54-59
18086875-5	2008	The interaction required Wrch1 to be in a GTP conformation and also required an intact N-terminal proline-rich extension as well as an intact effector loop.	Proline	98-105	ras homolog family member U	Homo sapiens	25-30
18264811-5	2008	RESULTS: Treatment with CLA isomers but not LA significantly reduced PDGF-stimulated [(3)H] proline incorporation into cell layer protein of SMCs without altering cell proliferation.	Proline	92-99	selectin P ligand	Homo sapiens	24-27
18088315-9	2008	Increased bZIP11 expression leads to decreased proline and increased phenylalanine levels.	Proline	47-54	G-box binding factor 6	Arabidopsis thaliana	10-16
18036351-4	2008	Overexpression of proline dehydrogenase (PRODH), a mitochondrial flavoenzyme that oxidizes proline, resulted in 6-fold lower intracellular proline content and decreased cell survival relative to control cells.	Proline	18-25	proline dehydrogenase 1	Homo sapiens	41-46
17964652-6	2008	Targeted mutagenesis of the proline residue at position 737 in the chTLR5-TIR domain was detrimental to chTLR5 function, confirming that the observed effects were conferred via chTLR5 and the MyD88 signaling pathway.	Proline	28-35	MYD88 innate immune signal transduction adaptor	Homo sapiens	192-197
18203802-6	2008	The entropic advantage of Pro versus Ala (DeltaDeltaS(U) = 11 +/- 2 J/mol K) was measured at the solvent-exposed P17 site.	Proline	26-29	family with sequence similarity 72 member B	Homo sapiens	113-116
18203802-7	2008	Pro-Ala mutations at two of the three prolines (P12 and P18) that encage the indole ring result in less fold destabilization (2.3-3.4 kJ/mol).	Proline	38-46	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	48-51
18203802-7	2008	Pro-Ala mutations at two of the three prolines (P12 and P18) that encage the indole ring result in less fold destabilization (2.3-3.4 kJ/mol).	Proline	38-46	H3 histone pseudogene 12	Homo sapiens	56-59
18319619-6	2008	Rat GnRHR in which the Ser-Glu-Pro (SEP) motif was changed to Pro-Glu-Val (PEV) or Pro-Glu-Ser (PES) had increased sensitivity to Trptorelix-2 but decreased sensitivity to Cetrorelix.	Proline	31-34	gonadotropin releasing hormone receptor	Rattus norvegicus	4-9
18301737-3	2008	Previous reports have shown that the formation of this heteromolecular complex involves interactions between a proline rich region of M2 and the Vav1 and Fyn SH3 domains.	Proline	111-118	vav guanine nucleotide exchange factor 1	Homo sapiens	145-149
18301737-3	2008	Previous reports have shown that the formation of this heteromolecular complex involves interactions between a proline rich region of M2 and the Vav1 and Fyn SH3 domains.	Proline	111-118	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	154-157
18301737-7	2008	Interestingly, signaling experiments indicate that the expression of M2 in B-cells promotes the tyrosine phosphorylation of Vav1 and additional signaling proteins, a biological process that requires the integrity of both the M2 phosphotyrosine and proline rich region motifs.	Proline	248-255	vav guanine nucleotide exchange factor 1	Homo sapiens	124-128
18289379-4	2008	Transduction of WASP peptides containing basic, verpolin-central, pTyr294, and proline-rich regions inhibited the processes listed above at various levels.	Proline	79-86	WASP actin nucleation promoting factor	Homo sapiens	16-20
18289379-5	2008	The ability to resorb bone by WASP peptides containing basic, verpolin-central, and proline-rich regions was reduced and the resorbed area matched the size of the sealing ring.	Proline	84-91	WASP actin nucleation promoting factor	Homo sapiens	30-34
18036351-4	2008	Overexpression of proline dehydrogenase (PRODH), a mitochondrial flavoenzyme that oxidizes proline, resulted in 6-fold lower intracellular proline content and decreased cell survival relative to control cells.	Proline	91-98	proline dehydrogenase 1	Homo sapiens	18-39
18036351-4	2008	Overexpression of proline dehydrogenase (PRODH), a mitochondrial flavoenzyme that oxidizes proline, resulted in 6-fold lower intracellular proline content and decreased cell survival relative to control cells.	Proline	91-98	proline dehydrogenase 1	Homo sapiens	41-46
18036351-5	2008	Cells overexpressing PRODH were rescued by pipecolate, an analog that mimics the antioxidant properties of proline, and by tetrahydro-2-furoic acid, a specific inhibitor of PRODH.	Proline	107-114	proline dehydrogenase 1	Homo sapiens	21-26
18036351-6	2008	In contrast, overexpression of the proline biosynthetic enzymes Delta(1)-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR) resulted in 2-fold higher proline content, significantly lower ROS levels, and increased cell survival relative to control cells.	Proline	35-42	aldehyde dehydrogenase 18 family member A1	Homo sapiens	115-119
18036351-6	2008	In contrast, overexpression of the proline biosynthetic enzymes Delta(1)-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR) resulted in 2-fold higher proline content, significantly lower ROS levels, and increased cell survival relative to control cells.	Proline	35-42	pyrroline-5-carboxylate reductase 1	Homo sapiens	125-138
18036351-6	2008	In contrast, overexpression of the proline biosynthetic enzymes Delta(1)-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR) resulted in 2-fold higher proline content, significantly lower ROS levels, and increased cell survival relative to control cells.	Proline	35-42	pyrroline-5-carboxylate reductase 1	Homo sapiens	140-144
18036351-6	2008	In contrast, overexpression of the proline biosynthetic enzymes Delta(1)-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR) resulted in 2-fold higher proline content, significantly lower ROS levels, and increased cell survival relative to control cells.	Proline	172-179	aldehyde dehydrogenase 18 family member A1	Homo sapiens	115-119
18036351-6	2008	In contrast, overexpression of the proline biosynthetic enzymes Delta(1)-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR) resulted in 2-fold higher proline content, significantly lower ROS levels, and increased cell survival relative to control cells.	Proline	172-179	pyrroline-5-carboxylate reductase 1	Homo sapiens	125-138
18036351-6	2008	In contrast, overexpression of the proline biosynthetic enzymes Delta(1)-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR) resulted in 2-fold higher proline content, significantly lower ROS levels, and increased cell survival relative to control cells.	Proline	172-179	pyrroline-5-carboxylate reductase 1	Homo sapiens	140-144
18036351-7	2008	In different mammalian cell lines exposed to physiological H(2)O(2) levels, increased endogenous P5CS and P5CR expression was observed, indicating that upregulation of proline biosynthesis is an oxidative stress response.	Proline	168-175	aldehyde dehydrogenase 18 family member A1	Homo sapiens	97-101
18036351-7	2008	In different mammalian cell lines exposed to physiological H(2)O(2) levels, increased endogenous P5CS and P5CR expression was observed, indicating that upregulation of proline biosynthesis is an oxidative stress response.	Proline	168-175	pyrroline-5-carboxylate reductase 1	Homo sapiens	106-110
17700527-3	2008	Here, we demonstrate that both hepatocytes growth factor (HGF) stimulation and v-Src transformation induce tyrosine phosphorylation of Dgk-alpha on Y335, through a mechanism requiring its proline-rich C-terminal sequence.	Proline	188-195	hepatocyte growth factor	Homo sapiens	31-56
18076874-3	2008	Treatment of cultured cardiac fibroblasts with 10 nM IGF-1 or 10 nM angiotensin II increased incorporation of proline.	Proline	110-117	insulin-like growth factor 1	Rattus norvegicus	53-58
18076874-3	2008	Treatment of cultured cardiac fibroblasts with 10 nM IGF-1 or 10 nM angiotensin II increased incorporation of proline.	Proline	110-117	angiotensinogen	Rattus norvegicus	68-82
18076874-8	2008	Tanshinone VI also partially attenuated angiotensin II-induced increase in proline incorporation into cardiac fibroblasts.	Proline	75-82	angiotensinogen	Rattus norvegicus	40-54
17700527-3	2008	Here, we demonstrate that both hepatocytes growth factor (HGF) stimulation and v-Src transformation induce tyrosine phosphorylation of Dgk-alpha on Y335, through a mechanism requiring its proline-rich C-terminal sequence.	Proline	188-195	hepatocyte growth factor	Homo sapiens	58-61
17700527-3	2008	Here, we demonstrate that both hepatocytes growth factor (HGF) stimulation and v-Src transformation induce tyrosine phosphorylation of Dgk-alpha on Y335, through a mechanism requiring its proline-rich C-terminal sequence.	Proline	188-195	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	81-84
17700527-3	2008	Here, we demonstrate that both hepatocytes growth factor (HGF) stimulation and v-Src transformation induce tyrosine phosphorylation of Dgk-alpha on Y335, through a mechanism requiring its proline-rich C-terminal sequence.	Proline	188-195	diacylglycerol kinase alpha	Homo sapiens	135-144
17700527-4	2008	Moreover, we show that both proline-rich sequence and phosphorylation of Y335 of Dgk-alpha mediate: (i) its enzymatic activation, (ii) its ability to interact respectively with SH3 and SH2 domains of Src, (iii) its recruitment to the membrane.	Proline	28-35	diacylglycerol kinase alpha	Homo sapiens	81-90
17700527-4	2008	Moreover, we show that both proline-rich sequence and phosphorylation of Y335 of Dgk-alpha mediate: (i) its enzymatic activation, (ii) its ability to interact respectively with SH3 and SH2 domains of Src, (iii) its recruitment to the membrane.	Proline	28-35	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	200-203
18083027-0	2008	In silico screening and biological evaluation of inhibitors of Src-SH3 domain interaction with a proline-rich ligand.	Proline	97-104	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	63-66
18094623-6	2008	We show that the proline-rich region is essential for the Bag3-mediated stimulation of mutated huntingtin clearance.	Proline	17-24	BAG cochaperone 3	Homo sapiens	58-62
18094623-6	2008	We show that the proline-rich region is essential for the Bag3-mediated stimulation of mutated huntingtin clearance.	Proline	17-24	huntingtin	Homo sapiens	95-105
18094623-8	2008	We propose that in the HspB8- Bag3 complex, HspB8 is responsible for recognizing the misfolded proteins whereas Bag3, at least in part through its proline-rich domain, might recruit and activate the macroautophagy machinery in close proximity to the chaperone-loaded substrates.	Proline	147-154	heat shock protein family B (small) member 8	Homo sapiens	23-28
18094623-8	2008	We propose that in the HspB8- Bag3 complex, HspB8 is responsible for recognizing the misfolded proteins whereas Bag3, at least in part through its proline-rich domain, might recruit and activate the macroautophagy machinery in close proximity to the chaperone-loaded substrates.	Proline	147-154	BAG cochaperone 3	Homo sapiens	30-34
18094623-8	2008	We propose that in the HspB8- Bag3 complex, HspB8 is responsible for recognizing the misfolded proteins whereas Bag3, at least in part through its proline-rich domain, might recruit and activate the macroautophagy machinery in close proximity to the chaperone-loaded substrates.	Proline	147-154	BAG cochaperone 3	Homo sapiens	112-116
18083027-2	2008	Here we report virtual screening for novel compounds that inhibit the Src-SH3 protein-protein interaction with a proline-rich peptide ligand.	Proline	113-120	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	70-73
18083027-5	2008	A benzoquinoline derivative showed micromolar inhibition of binding between Src-SH3 and the proline-rich peptide.	Proline	92-99	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	76-79
18083557-1	2008	The stereoselective synthesis of aminooxy-containing proline analogues bearing Fmoc/Boc or Fmoc/Mtt protection that renders them suitable for incorporation into peptides using Fmoc protocols is reported.	Proline	53-60	BOC cell adhesion associated, oncogene regulated	Homo sapiens	84-87
18163987-2	2008	Previous studies have shown that the SH3, DHR1 and DHR2 domains of Myoblast city (MBC) are essential for it to direct myoblast fusion in the Drosophila embryo, while the conserved DCrk-binding proline rich region is expendable.	Proline	193-200	Crk oncogene	Drosophila melanogaster	180-184
18037365-3	2008	The same study showed that a Proline insertion-deletion polymorphism at amino acid position 704 (Pro704 ins/del) in the RIZ1 gene was associated with heel BMD in young Swedish women.	Proline	29-36	PR/SET domain 2	Homo sapiens	120-124
18163987-3	2008	Herein, we describe the isolation of Drosophila ELMO/CED-12, an approximately 82 kDa protein with a pleckstrin homology (PH) and proline-rich domain, by interaction with the MBC SH3 domain.	Proline	129-136	Ced-12	Drosophila melanogaster	48-52
18163987-3	2008	Herein, we describe the isolation of Drosophila ELMO/CED-12, an approximately 82 kDa protein with a pleckstrin homology (PH) and proline-rich domain, by interaction with the MBC SH3 domain.	Proline	129-136	Ced-12	Drosophila melanogaster	53-59
23480220-1	2008	BACKGROUND: The p38 kinases (p38) are proline-directed serine/threonine enzymes of the mitogen-activated protein kinase family.	Proline	38-45	mitogen-activated protein kinase 14	Homo sapiens	16-19
23480220-1	2008	BACKGROUND: The p38 kinases (p38) are proline-directed serine/threonine enzymes of the mitogen-activated protein kinase family.	Proline	38-45	mitogen-activated protein kinase 14	Homo sapiens	29-32
17928366-5	2008	MEK1-mediated ERK2 nuclear translocation and proliferation were shown to depend on phosphorylation of S298 and T292 sites in the MEK1 proline-rich domain.	Proline	134-141	mitogen-activated protein kinase kinase 1	Homo sapiens	0-4
18032080-3	2008	This sequence is highly homologous to SOX11 of other species and contained the signature features of mammalian SOX11 homologues, except for the absence of Pro-Glu rich region and presence of two Ser-rich regions.	Proline	155-158	SRY-box transcription factor 11	Homo sapiens	111-116
18032080-3	2008	This sequence is highly homologous to SOX11 of other species and contained the signature features of mammalian SOX11 homologues, except for the absence of Pro-Glu rich region and presence of two Ser-rich regions.	Proline	155-158	SRY-box transcription factor 11	Homo sapiens	38-43
17928366-5	2008	MEK1-mediated ERK2 nuclear translocation and proliferation were shown to depend on phosphorylation of S298 and T292 sites in the MEK1 proline-rich domain.	Proline	134-141	mitogen-activated protein kinase 1	Homo sapiens	14-18
17928366-5	2008	MEK1-mediated ERK2 nuclear translocation and proliferation were shown to depend on phosphorylation of S298 and T292 sites in the MEK1 proline-rich domain.	Proline	134-141	mitogen-activated protein kinase kinase 1	Homo sapiens	129-133
18209080-9	2008	The proline/serine/threonine region of CIITA showed significant decrease in phosphorylation at high IFN-gamma levels.	Proline	4-11	class II major histocompatibility complex transactivator	Homo sapiens	39-44
18209080-9	2008	The proline/serine/threonine region of CIITA showed significant decrease in phosphorylation at high IFN-gamma levels.	Proline	4-11	interferon gamma	Homo sapiens	100-109
18060533-2	2008	To investigate on the possible role of proline in flowering, we altered the expression of AtP5CS1, encoding the rate-limiting enzyme of proline biosynthesis in plants.	Proline	39-46	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	90-97
18266263-3	2008	Recently, we characterized two proline-rich peptides (SP-A and SP-B) in parotid secretory granules of pig (Sus Scrofa) that are derived from three isoforms of a PRP proprotein (Swiss-Prot data bank: Q95JC9-1, Q95JC9-2 and Q95JC9-3).	Proline	31-38	pulmonary surfactant-associated protein A	Sus scrofa	54-58
18266263-3	2008	Recently, we characterized two proline-rich peptides (SP-A and SP-B) in parotid secretory granules of pig (Sus Scrofa) that are derived from three isoforms of a PRP proprotein (Swiss-Prot data bank: Q95JC9-1, Q95JC9-2 and Q95JC9-3).	Proline	31-38	surfactant protein B	Sus scrofa	63-67
18086881-7	2008	Binding to hundreds of sites on the X chromosome and efficient incorporation of the roX RNAs into the MSL complex require proline-rich and basic motifs in the carboxyl-terminal domain of MSL2.	Proline	122-129	long non-coding RNA on the X 2	Drosophila melanogaster	84-87
18086881-7	2008	Binding to hundreds of sites on the X chromosome and efficient incorporation of the roX RNAs into the MSL complex require proline-rich and basic motifs in the carboxyl-terminal domain of MSL2.	Proline	122-129	male-specific lethal 2	Drosophila melanogaster	187-191
18032512-3	2008	We found that a single-amino-acid substitution of serine for proline at position 42 (P42S) in the NS1 protein dramatically increased the virulence of the DK/12 virus in mice, whereas the substitution of proline for serine at the same position (S42P) completely attenuated the DK/27 virus.	Proline	61-68	influenza virus NS1A binding protein	Mus musculus	98-101
18039859-4	2008	This interaction is mediated through four serine-proline motifs in the C terminus of PML.	Proline	49-56	PML nuclear body scaffold	Homo sapiens	85-88
18060533-2	2008	To investigate on the possible role of proline in flowering, we altered the expression of AtP5CS1, encoding the rate-limiting enzyme of proline biosynthesis in plants.	Proline	136-143	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	90-97
18060533-5	2008	In addition p5cs1 mutants exhibited a shorter size and contained lower levels of proline, compared to wild type.	Proline	81-88	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	12-17
18060533-6	2008	35S-P5CS1 plants, manifested, early in development, overexpression of P5CS1 and accumulation of proline, leading to early flowering, both under long- and short-day conditions.	Proline	96-103	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	4-9
18060533-7	2008	Later in development, down-regulation of P5CS1 occurred in 35S-P5CS1 leaves, leading to proline reduction, and, in turn, impaired bolting and stunted growth.	Proline	88-95	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	41-46
18060533-7	2008	Later in development, down-regulation of P5CS1 occurred in 35S-P5CS1 leaves, leading to proline reduction, and, in turn, impaired bolting and stunted growth.	Proline	88-95	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	63-68
18060533-8	2008	Salt-stress restored expression of P5CS1 and proline accumulation in P5CS1-transformed plants, as well as rescuing growth.	Proline	45-52	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	69-74
18035046-5	2008	This indicates that P727L polymorphism causes loss of sensitivity of CLCN1 to the DEA/NO treatment, which could be due to a conformational change caused by proline substitution.	Proline	156-163	chloride voltage-gated channel 1	Homo sapiens	69-74
17991736-2	2008	Here we report that CIITA represses collagen transcription through a phosphorylation-dependent interaction between its proline/serine/threonine domain and co-repressor molecules such as histone deacetylase (HDAC2) and Sin3B.	Proline	119-126	class II major histocompatibility complex transactivator	Homo sapiens	20-25
18088090-1	2008	A variety of dicarboxylic acid linkers introduced between the alpha-amino group of Pro(6) and the -amino group of Lys(10) of the cyclic lactam alpha-melanocyte-stimulating hormone (alpha-MSH)-derived Pro(6)-D-Phe(7)/D-Nal(2")(7)-Arg(8)-Trp(9)-Lys(10)-NH2 pentapeptide template lead to nanomolar range and selective hMC3R agonists and antagonists.	Proline	200-203	proopiomelanocortin	Homo sapiens	143-179
18088090-1	2008	A variety of dicarboxylic acid linkers introduced between the alpha-amino group of Pro(6) and the -amino group of Lys(10) of the cyclic lactam alpha-melanocyte-stimulating hormone (alpha-MSH)-derived Pro(6)-D-Phe(7)/D-Nal(2")(7)-Arg(8)-Trp(9)-Lys(10)-NH2 pentapeptide template lead to nanomolar range and selective hMC3R agonists and antagonists.	Proline	200-203	proopiomelanocortin	Homo sapiens	181-190
18068721-6	2008	Disruption of the beta-hairpin (whose sequence is conserved among NAP1 proteins in various species) by the replacement of one or more amino acids with proline results in complete loss of yNAP1 dimer oligomerization.	Proline	151-158	histone chaperone NAP1	Saccharomyces cerevisiae S288C	66-70
18068721-6	2008	Disruption of the beta-hairpin (whose sequence is conserved among NAP1 proteins in various species) by the replacement of one or more amino acids with proline results in complete loss of yNAP1 dimer oligomerization.	Proline	151-158	histone chaperone NAP1	Saccharomyces cerevisiae S288C	187-192
17991736-2	2008	Here we report that CIITA represses collagen transcription through a phosphorylation-dependent interaction between its proline/serine/threonine domain and co-repressor molecules such as histone deacetylase (HDAC2) and Sin3B.	Proline	119-126	histone deacetylase 2	Homo sapiens	207-212
17991736-2	2008	Here we report that CIITA represses collagen transcription through a phosphorylation-dependent interaction between its proline/serine/threonine domain and co-repressor molecules such as histone deacetylase (HDAC2) and Sin3B.	Proline	119-126	SIN3 transcription regulator family member B	Homo sapiens	218-223
18199773-2	2008	They are based on the regulatable expression of the four-repeat domain of human Tau carrying the FTDP17 (frontotemporal dementia and parkinsonism linked to chromosome 17) mutation deltaK280 (Tau(RD)/deltaK280), or the deltaK280 plus two proline mutations in the hexapeptide motifs (Tau(RD)/deltaK280/I277P/I308P).	Proline	237-244	microtubule associated protein tau	Homo sapiens	80-83
18199773-2	2008	They are based on the regulatable expression of the four-repeat domain of human Tau carrying the FTDP17 (frontotemporal dementia and parkinsonism linked to chromosome 17) mutation deltaK280 (Tau(RD)/deltaK280), or the deltaK280 plus two proline mutations in the hexapeptide motifs (Tau(RD)/deltaK280/I277P/I308P).	Proline	237-244	microtubule associated protein tau	Homo sapiens	97-103
18199773-3	2008	The deltaK280 mutation accelerates aggregation ("proaggregation mutant"), whereas the proline mutations inhibit Tau aggregation in vitro and in cell models ("antiaggregation mutant").	Proline	86-93	microtubule associated protein tau	Homo sapiens	112-115
18001770-1	2008	Profilins are small proteins capable of binding actin, poly-l-proline and other proline-rich sequences, and phosphatidylinositol (4,5)-bisphosphate.	Proline	62-69	profilin 1	Homo sapiens	0-9
18067320-0	2008	Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.	Proline	15-22	myelin basic protein	Homo sapiens	39-59
18067320-2	2008	A central segment of MBP is highly conserved in mammals and consists of a membrane surface-associated amphipathic alpha-helix, immediately followed by a proline-rich segment that we hypothesize is an SH3 ligand.	Proline	153-160	myelin basic protein	Homo sapiens	21-24
18067320-6	2008	Phosphorylation of rmC1 at 1-2 threonines within the proline-rich segment by mitogen-activated protein kinase in vitro has no effect on the binding specificity to the SH3 domains on the array.	Proline	53-60	xenotropic and polytropic retrovirus receptor 1	Mus musculus	19-23
18178845-7	2008	Converting a single proline residue located in this region of GATA-4 to its counterpart, a methionine of GATA-3, was sufficient to enhance the IL-13-promoting function of GATA-4 but had no effect on other cytokines.	Proline	20-27	GATA binding protein 4	Homo sapiens	62-68
18178845-7	2008	Converting a single proline residue located in this region of GATA-4 to its counterpart, a methionine of GATA-3, was sufficient to enhance the IL-13-promoting function of GATA-4 but had no effect on other cytokines.	Proline	20-27	GATA binding protein 3	Homo sapiens	105-111
18178845-7	2008	Converting a single proline residue located in this region of GATA-4 to its counterpart, a methionine of GATA-3, was sufficient to enhance the IL-13-promoting function of GATA-4 but had no effect on other cytokines.	Proline	20-27	interleukin 13	Homo sapiens	143-148
18178845-7	2008	Converting a single proline residue located in this region of GATA-4 to its counterpart, a methionine of GATA-3, was sufficient to enhance the IL-13-promoting function of GATA-4 but had no effect on other cytokines.	Proline	20-27	GATA binding protein 4	Homo sapiens	171-177
18178851-3	2008	By genetic and functional studies, we found that Arg75Thr and Tyr85Phe mutations, located in a well-conserved proline-rich region in Nef, were differently associated with escape from CTL responses specific for two overlapping HLA-B35-restricted epitopes.	Proline	110-117	S100 calcium binding protein B	Homo sapiens	133-136
18062707-2	2008	Pin1 is a peptide prolyl cis/trans isomerase conserved among eukaryotes that specifically reacts with proteins phosphorylated at Ser/Thr-Pro sites.	Proline	137-140	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
18001770-8	2008	Mutant profilins were tested for binding to poly-L-proline and the VASP and mDia1 peptides, and the F139A mutant bound proline-rich ligands with near-native affinity.	Proline	51-58	profilin 1	Homo sapiens	7-16
18001770-9	2008	Peptide blotting using a series of designed peptides with profilins 1 and 2a indicates differences between the two profilins towards proline-rich peptides from mDia1 and VASP.	Proline	133-140	profilin 1	Homo sapiens	58-75
18001770-9	2008	Peptide blotting using a series of designed peptides with profilins 1 and 2a indicates differences between the two profilins towards proline-rich peptides from mDia1 and VASP.	Proline	133-140	profilin 1	Homo sapiens	58-67
18001770-9	2008	Peptide blotting using a series of designed peptides with profilins 1 and 2a indicates differences between the two profilins towards proline-rich peptides from mDia1 and VASP.	Proline	133-140	diaphanous related formin 1	Mus musculus	160-165
18001770-9	2008	Peptide blotting using a series of designed peptides with profilins 1 and 2a indicates differences between the two profilins towards proline-rich peptides from mDia1 and VASP.	Proline	133-140	vasodilator stimulated phosphoprotein	Homo sapiens	170-174
19065769-3	2008	TP53 codon 72 polymorphism results in either the arginine or proline form of the p53 protein; several studies have investigated whether codon 72 polymorphisms are risk and prognostic factors for cancer.	Proline	61-68	tumor protein p53	Homo sapiens	0-4
18183932-1	2008	A proline-rich polypeptide (PRP), later called colostrinin (CLN), was originally found as a fraction accompanying sheep colostral immunoglobulins.	Proline	2-9	proline rich protein HaeIII subfamily 1	Mus musculus	28-31
19238244-6	2008	The chloro substituted naphthyl ring of compound 63 makes significant hydrophobic contact with Leu 22, Phe 31 and Pro 61 of the DHFR active site leading to enhanced inhibition of the enzyme.	Proline	114-117	dihydrofolate reductase	Homo sapiens	128-132
18673218-9	2008	Of interest, the intracellular portion of FasL contains a unique proline-rich domain, which plays a major role in the control of FasL transport and expression due to interactions with proteins containing SH3 or WW interaction domains.	Proline	65-72	Fas ligand	Homo sapiens	42-46
18673218-9	2008	Of interest, the intracellular portion of FasL contains a unique proline-rich domain, which plays a major role in the control of FasL transport and expression due to interactions with proteins containing SH3 or WW interaction domains.	Proline	65-72	Fas ligand	Homo sapiens	129-133
17494108-3	2008	AIMS: This study determined the efficiency of gluten degradation by a post-proline cutting enzyme, Aspergillus niger prolyl endoprotease (AN-PEP), in a dynamic system that closely mimics the human gastrointestinal tract (TIM system).	Proline	75-82	Rho guanine nucleotide exchange factor 5	Homo sapiens	221-224
19065769-3	2008	TP53 codon 72 polymorphism results in either the arginine or proline form of the p53 protein; several studies have investigated whether codon 72 polymorphisms are risk and prognostic factors for cancer.	Proline	61-68	tumor protein p53	Homo sapiens	81-84
18535365-6	2008	injection of the Y1-R agonists, [Leu(31), Pro(34)]NPY, [D-Arg(25)]NPY or NPY, an effect which was completely blocked by prior intravenous administration of the Y1R antagonist, BIBP3226.	Proline	42-45	neuropeptide Y	Rattus norvegicus	50-53
18787627-6	2008	The t(8;13)(p11;q11) disrupts intron 8 of the FGFR1 gene and fuses proline-rich and zinc finger domains of the ZNF198 gene with the cytoplasmic tyrosine kinase domain of FGFR1.	Proline	67-74	zinc finger MYM-type containing 2	Homo sapiens	111-117
18803266-0	2008	p53 codon 72 proline/arginine polymorphism and autoimmune thyroid diseases.	Proline	13-20	tumor protein p53	Homo sapiens	0-3
18803266-8	2008	The p53 codon 72 proline/arginine polymorphism may be a genetic marker to predict the increased susceptibility of development of HT.	Proline	17-24	tumor protein p53	Homo sapiens	4-7
19165611-7	2008	cTnT was predominantly monophosphorylated and partially proteolyzed at the Glu(29)-Pro(30) peptide bond.	Proline	83-86	troponin T2, cardiac type	Rattus norvegicus	0-4
18429752-8	2008	Compared with carriers of genotype Ser/Ser carriers of genotype Ser/Pro of polymorphic marker Pro34Ser of Cyp2D6 gene had significantly more pronounced decrease of HR at the background of treatment with betaxolol: - 32,6 +/- 4,77 and - 18,4 +/- 2,01 beats/min (p=0,023) at rest and - 30,1 +/- 3,05 and - 24,0 +/- 2,59 beats/min (p=0,043) at maximal exercise, respectively.	Proline	68-71	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	106-112
18354249-2	2008	We, and others, have previously reported that thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH(2)) and TRH-like peptides with the general structure pGlu-X-Pro-NH(2), where "X" can be any amino acid residue, have neuroprotective, antidepressant, analeptic, arousal, and anti-epileptic effects that could mediate the neuropsychiatric and therapeutic effects of a variety of neurotropic agents.	Proline	91-94	thyrotropin releasing hormone	Rattus norvegicus	46-75
18354249-2	2008	We, and others, have previously reported that thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH(2)) and TRH-like peptides with the general structure pGlu-X-Pro-NH(2), where "X" can be any amino acid residue, have neuroprotective, antidepressant, analeptic, arousal, and anti-epileptic effects that could mediate the neuropsychiatric and therapeutic effects of a variety of neurotropic agents.	Proline	91-94	thyrotropin releasing hormone	Rattus norvegicus	77-80
17926058-1	2008	Ankyrin-repeat protein with a PEST motif and a proline-rich region (Arpp), also designated as Ankrd2, is a member of the muscle ankyrin repeat proteins (MARPs), which have been proposed to be involved in muscle stress response pathways.	Proline	47-54	ankyrin repeat domain 2	Homo sapiens	68-72
17926058-1	2008	Ankyrin-repeat protein with a PEST motif and a proline-rich region (Arpp), also designated as Ankrd2, is a member of the muscle ankyrin repeat proteins (MARPs), which have been proposed to be involved in muscle stress response pathways.	Proline	47-54	ankyrin repeat domain 2	Homo sapiens	94-100
18083058-4	2008	We have introduced specific mutations into a conserved motif at the mid-point of the Cys-loop of the GABA A receptor subunits alpha1, beta2 and gamma2S where the sequence reads aromatic, proline, aliphatic (ArProAl motif).	Proline	187-194	hemoglobin, beta adult minor chain	Mus musculus	134-139
17457363-0	2008	Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury.	Proline	26-33	AKT serine/threonine kinase 1	Rattus norvegicus	39-42
17457363-0	2008	Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury.	Proline	26-33	AKT1 substrate 1	Homo sapiens	54-60
17457363-2	2008	A proline-rich Akt substrate, PRAS40, has been characterized, and an increase in phospho-PRAS40 (pPRAS40) is neuroprotective after transient focal cerebral ischemia.	Proline	2-9	AKT serine/threonine kinase 1	Rattus norvegicus	15-18
17457363-2	2008	A proline-rich Akt substrate, PRAS40, has been characterized, and an increase in phospho-PRAS40 (pPRAS40) is neuroprotective after transient focal cerebral ischemia.	Proline	2-9	AKT1 substrate 1	Rattus norvegicus	30-36
17942596-2	2008	Under normal oxygen conditions, HIF-1alpha, the active subunit of HIF-1, is hydroxylated on proline residues by specific HIF prolyl-hydroxylases, leading to ubiquitination and degradation by the proteasome.	Proline	92-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
17942596-2	2008	Under normal oxygen conditions, HIF-1alpha, the active subunit of HIF-1, is hydroxylated on proline residues by specific HIF prolyl-hydroxylases, leading to ubiquitination and degradation by the proteasome.	Proline	92-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
17942596-6	2008	We show that hydroxylation on proline 402 is altered by Ang II, decreasing pVHL binding to HIF-1alpha and allowing HIF-1alpha protein to escape subsequent ubiquitination and degradation mechanisms.	Proline	30-37	von Hippel-Lindau tumor suppressor	Homo sapiens	75-79
17673295-6	2008	It was significant that the FcgammaRIIa consensus peptide sequence contained a Proline (Pro3), which when substituted with alanine abrogated FcgammaRIIa binding, consistent with Pro3 contributing to receptor binding.	Proline	79-86	Fc gamma receptor IIa	Homo sapiens	28-39
17673295-6	2008	It was significant that the FcgammaRIIa consensus peptide sequence contained a Proline (Pro3), which when substituted with alanine abrogated FcgammaRIIa binding, consistent with Pro3 contributing to receptor binding.	Proline	79-86	pyrroline-5-carboxylate reductase 1	Homo sapiens	88-92
17673295-6	2008	It was significant that the FcgammaRIIa consensus peptide sequence contained a Proline (Pro3), which when substituted with alanine abrogated FcgammaRIIa binding, consistent with Pro3 contributing to receptor binding.	Proline	79-86	Fc gamma receptor IIa	Homo sapiens	141-152
17673295-6	2008	It was significant that the FcgammaRIIa consensus peptide sequence contained a Proline (Pro3), which when substituted with alanine abrogated FcgammaRIIa binding, consistent with Pro3 contributing to receptor binding.	Proline	79-86	pyrroline-5-carboxylate reductase 1	Homo sapiens	178-182
18670615-5	2008	Previous studies showed that proline oxidase is a p53-induced gene and its overexpression can initiate proline-dependent apoptosis by both intrinsic and extrinsic pathways.	Proline	29-36	tumor protein p53	Homo sapiens	50-53
17971042-3	2008	Here we describe the genetic characterization of p5cs insertion mutants, which indicates that P5CS1 is required for proline accumulation under osmotic stress.	Proline	116-123	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	94-99
17971042-4	2008	Knockout mutations of P5CS1 result in the reduction of stress-induced proline synthesis, hypersensitivity to salt stress, and accumulation of reactive oxygen species.	Proline	70-77	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	22-27
17971042-8	2008	Although proline feeding rescues the viability of mutant embryos, p5cs2 seedlings undergo aberrant development and fail to produce fertile plants even when grown on proline.	Proline	165-172	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	66-71
18612219-1	2008	BACKGROUND: The p53 codon 72 polymorphism, which results in either an arginine or proline residue, plays a different role in vitro and in vivo in cell survival and drug resistance.	Proline	82-89	tumor protein p53	Homo sapiens	16-19
18197538-2	2008	Polymorphisms in the signal sequence genetically may be responsible for increased TGF-beta1 production (i.e., a substitution at amino acid position 10 and 25, +869 Leu(10)-Pro and +915 Arg(25)-Pro, respectively).	Proline	172-175	transforming growth factor beta 1	Homo sapiens	82-91
18197538-2	2008	Polymorphisms in the signal sequence genetically may be responsible for increased TGF-beta1 production (i.e., a substitution at amino acid position 10 and 25, +869 Leu(10)-Pro and +915 Arg(25)-Pro, respectively).	Proline	193-196	transforming growth factor beta 1	Homo sapiens	82-91
18991770-8	2008	Homology modeling of PPM1D also revealed that PPM1D contains two characteristic loops, a Pro-residue rich loop on the opposite side of the active site and a basic-residue rich loop in the vicinity of the active site in the catalytic domain.	Proline	89-92	protein phosphatase, Mg2+/Mn2+ dependent 1D	Homo sapiens	21-26
18991770-8	2008	Homology modeling of PPM1D also revealed that PPM1D contains two characteristic loops, a Pro-residue rich loop on the opposite side of the active site and a basic-residue rich loop in the vicinity of the active site in the catalytic domain.	Proline	89-92	protein phosphatase, Mg2+/Mn2+ dependent 1D	Homo sapiens	46-51
17911381-4	2007	Allelic variation of the Tas1r3 gene influenced taste responsiveness to nonnutritive sweeteners (saccharin, acesulfame-K, sucralose, SC-45647), sugars (sucrose, maltose, glucose, fructose), sugar alcohols (erythritol, sorbitol), and some amino acids (D-tryptophan, D-phenylalanine, L-proline).	Proline	282-291	taste receptor, type 1, member 3	Mus musculus	25-31
18357725-1	2008	Pin1 is a phosphorylation-dependent peptidyl-prolyl cis/trans isomerase, which specifically catalyzes the amide bond isomerization of phosphoserine-proline or phosphothreonine-proline in mitotic phosphoproteins.	Proline	148-155	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
18093523-2	2007	One such enzyme is synaptojanin1, a multifunctional protein conserved from yeast to humans, which contains two phosphoinositol phosphatase domains and a proline-rich domain.	Proline	153-160	synaptojanin 1	Homo sapiens	19-32
17714073-9	2007	These proline residues are also necessary for ZO-1 interaction.	Proline	6-13	tight junction protein 1	Rattus norvegicus	46-50
20641798-8	2004	alpha-MSH (Ac-Ser(1)-Tyr(2)-Ser(3)-Met(4)-Glu(5)-His(6)-Phe(7)-Arg(8)-Trp(9)-Gly(10)-Lys(11)-Pro(12)-Val(13)-NH2), composed of 13 amino acids, is the most potent naturally occurring melanotropic peptide (5).	Proline	93-96	pro-opiomelanocortin-alpha	Mus musculus	0-9
17931606-0	2007	Deletion of v7-3 (SLC6A15) transporter allows assessment of its roles in synaptosomal proline uptake, leucine uptake and behaviors.	Proline	86-93	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	12-16
17956868-9	2007	Conversely, when His-40 residue of UGT1A3 was replaced with proline, the substrate specificity shifted toward that of UGT1A4 with loss of glucuronidation of phenolic substrates.	Proline	60-67	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	35-41
17956868-9	2007	Conversely, when His-40 residue of UGT1A3 was replaced with proline, the substrate specificity shifted toward that of UGT1A4 with loss of glucuronidation of phenolic substrates.	Proline	60-67	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	118-124
17956868-10	2007	Furthermore, mutation of His-39 residue of UGT1A1 (His-40 in UGT1A4) to proline led to loss of glucuronidation of phenols but not of estrogens.	Proline	72-79	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	43-49
17956868-10	2007	Furthermore, mutation of His-39 residue of UGT1A1 (His-40 in UGT1A4) to proline led to loss of glucuronidation of phenols but not of estrogens.	Proline	72-79	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	61-67
17602703-6	2007	She had a MPZ mutation with A-C transversion (nucleotide: 116, codon: 10, histidine-to-proline).	Proline	87-94	myelin protein zero	Bos taurus	10-13
17931606-0	2007	Deletion of v7-3 (SLC6A15) transporter allows assessment of its roles in synaptosomal proline uptake, leucine uptake and behaviors.	Proline	86-93	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	18-25
17931606-5	2007	While our studies were in progress, v7-3 expression was reported to confer transport of proline and branched-chain amino acids in in vitro expression systems [Takanaga, H., Mackenzie, B., Peng, J.B., Hediger, M.A., 2005b.	Proline	88-95	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	36-40
17931606-16	2007	Assessment of amino acid uptake into cortical synaptosomes of v7-3 knockouts identified 15% and 40% reductions in sodium-dependent proline and leucine transport, respectively, compared to wild type controls.	Proline	131-138	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	62-66
17931606-19	2007	The current results place v7-3 in the context of other brain transporters that accumulate proline and branched-chain amino acids.	Proline	90-97	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	26-30
18076569-2	2007	Cyclin-dependent kinase 5 (Cdk5)-p35 is a proline-directed Ser/Thr kinase also involved in neuronal migration.	Proline	42-49	cyclin dependent kinase 5	Homo sapiens	0-25
18048323-3	2007	We hypothesize that the constitutive activation of TRPML3 occurs as a result of a helix-breaking proline substitution in transmembrane-spanning domain 5 (TM5).	Proline	97-104	mucolipin 3	Mus musculus	51-57
18048323-4	2007	A proline substitution scan demonstrated that the inner third of TRPML3"s TM5 is highly susceptible to proline-based kinks.	Proline	2-9	mucolipin 3	Mus musculus	65-71
18048323-4	2007	A proline substitution scan demonstrated that the inner third of TRPML3"s TM5 is highly susceptible to proline-based kinks.	Proline	103-110	mucolipin 3	Mus musculus	65-71
18048323-5	2007	Proline substitutions in TM5 of other TRP channels revealed that TRPML1, TRPML2, TRPV5, and TRPV6 display a similar susceptibility at comparable positions, whereas other TRP channels were not affected.	Proline	0-7	mucolipin 1	Mus musculus	65-71
18048323-5	2007	Proline substitutions in TM5 of other TRP channels revealed that TRPML1, TRPML2, TRPV5, and TRPV6 display a similar susceptibility at comparable positions, whereas other TRP channels were not affected.	Proline	0-7	mucolipin 2	Mus musculus	73-79
18048323-5	2007	Proline substitutions in TM5 of other TRP channels revealed that TRPML1, TRPML2, TRPV5, and TRPV6 display a similar susceptibility at comparable positions, whereas other TRP channels were not affected.	Proline	0-7	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	81-86
18048323-5	2007	Proline substitutions in TM5 of other TRP channels revealed that TRPML1, TRPML2, TRPV5, and TRPV6 display a similar susceptibility at comparable positions, whereas other TRP channels were not affected.	Proline	0-7	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	92-97
18282137-6	2007	However, high concentrations of proline, betaine, and TMAO completely suppress the formation of PhK complex with phosphorylase b (Phb).	Proline	32-39	prohibitin 1	Homo sapiens	113-128
18282137-6	2007	However, high concentrations of proline, betaine, and TMAO completely suppress the formation of PhK complex with phosphorylase b (Phb).	Proline	32-39	prohibitin 1	Homo sapiens	130-133
18061561-4	2007	We have identified Drosophila Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein (dASPP) as a regulator of Drosophila Csk (dCsk) activity.	Proline	62-69	Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein	Drosophila melanogaster	102-107
18061561-4	2007	We have identified Drosophila Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein (dASPP) as a regulator of Drosophila Csk (dCsk) activity.	Proline	62-69	C-terminal Src kinase	Drosophila melanogaster	138-141
18061561-4	2007	We have identified Drosophila Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein (dASPP) as a regulator of Drosophila Csk (dCsk) activity.	Proline	62-69	C-terminal Src kinase	Drosophila melanogaster	143-147
17869481-4	2007	The N-SH3 domain of Grb2 is linked to a proline-rich sequence of the C2 domain of PLC-gamma1, PLC-gamma1 itself is linked, through its SH3 domain, to the C-terminal proline-rich region of Sos.	Proline	40-47	growth factor receptor bound protein 2	Homo sapiens	20-24
17869481-4	2007	The N-SH3 domain of Grb2 is linked to a proline-rich sequence of the C2 domain of PLC-gamma1, PLC-gamma1 itself is linked, through its SH3 domain, to the C-terminal proline-rich region of Sos.	Proline	40-47	phospholipase C gamma 1	Homo sapiens	82-92
17869481-4	2007	The N-SH3 domain of Grb2 is linked to a proline-rich sequence of the C2 domain of PLC-gamma1, PLC-gamma1 itself is linked, through its SH3 domain, to the C-terminal proline-rich region of Sos.	Proline	40-47	phospholipase C gamma 1	Homo sapiens	94-104
17869481-4	2007	The N-SH3 domain of Grb2 is linked to a proline-rich sequence of the C2 domain of PLC-gamma1, PLC-gamma1 itself is linked, through its SH3 domain, to the C-terminal proline-rich region of Sos.	Proline	165-172	growth factor receptor bound protein 2	Homo sapiens	20-24
17869481-4	2007	The N-SH3 domain of Grb2 is linked to a proline-rich sequence of the C2 domain of PLC-gamma1, PLC-gamma1 itself is linked, through its SH3 domain, to the C-terminal proline-rich region of Sos.	Proline	165-172	phospholipase C gamma 1	Homo sapiens	82-92
17869481-4	2007	The N-SH3 domain of Grb2 is linked to a proline-rich sequence of the C2 domain of PLC-gamma1, PLC-gamma1 itself is linked, through its SH3 domain, to the C-terminal proline-rich region of Sos.	Proline	165-172	phospholipase C gamma 1	Homo sapiens	94-104
18220518-3	2007	In the cell models the repeat domain of tau (tau(RD)) and some of its variants are expressed in a regulated fashion, e.g. the 4-repeat domain of tau with the wild-type sequence, the repeat domain with the deltaK280 mutation ("pro-aggregation mutant"), or the repeat domain with additional proline mutations ("anti-aggregation mutant").	Proline	289-296	microtubule associated protein tau	Homo sapiens	40-43
18220518-3	2007	In the cell models the repeat domain of tau (tau(RD)) and some of its variants are expressed in a regulated fashion, e.g. the 4-repeat domain of tau with the wild-type sequence, the repeat domain with the deltaK280 mutation ("pro-aggregation mutant"), or the repeat domain with additional proline mutations ("anti-aggregation mutant").	Proline	289-296	microtubule associated protein tau	Homo sapiens	45-48
18220518-3	2007	In the cell models the repeat domain of tau (tau(RD)) and some of its variants are expressed in a regulated fashion, e.g. the 4-repeat domain of tau with the wild-type sequence, the repeat domain with the deltaK280 mutation ("pro-aggregation mutant"), or the repeat domain with additional proline mutations ("anti-aggregation mutant").	Proline	289-296	microtubule associated protein tau	Homo sapiens	45-48
17978002-10	2007	Thus, we propose that sens/pros antagonism is important for regulating many biological processes.	Proline	27-31	senseless	Drosophila melanogaster	22-26
17875631-8	2007	We reveal in this study that C. posadasii produces a homolog of the reported proline-rich antigen, designated Prp2, which shows 69% protein sequence identity and 86% similarity to Ag2/Pra.	Proline	77-84	S100 calcium binding protein A6 (calcyclin)	Mus musculus	184-187
17714777-1	2007	Prolyl endopeptidase (PEP, EC 3.4.21.26) is a proline-specific endopeptidase with a serine-type mechanism, which digests small peptide-like hormones, neuroactive peptides, and various cellular factors.	Proline	46-53	prolyl endopeptidase	Homo sapiens	0-20
18076569-2	2007	Cyclin-dependent kinase 5 (Cdk5)-p35 is a proline-directed Ser/Thr kinase also involved in neuronal migration.	Proline	42-49	cyclin dependent kinase 5	Homo sapiens	27-31
18076569-2	2007	Cyclin-dependent kinase 5 (Cdk5)-p35 is a proline-directed Ser/Thr kinase also involved in neuronal migration.	Proline	42-49	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	33-36
17714777-1	2007	Prolyl endopeptidase (PEP, EC 3.4.21.26) is a proline-specific endopeptidase with a serine-type mechanism, which digests small peptide-like hormones, neuroactive peptides, and various cellular factors.	Proline	46-53	prolyl endopeptidase	Homo sapiens	22-25
17938211-5	2007	In both the yeast model and mammalian cells, the FKBP51 mutation L119P, which is located in a hairpin loop overhanging the catalytic pocket and introduces the proline found in FKBP52, conferred significant potentiation activity, whereas the converse P119L mutation in FKBP52 decreased potentiation.	Proline	159-166	FKBP prolyl isomerase 4	Homo sapiens	176-182
17875631-2	2007	A recombinant proline-rich antigen (rAg2/Pra) has been reported to be a leading vaccine candidate.	Proline	14-21	similar to LOC387763 protein	Rattus norvegicus	36-40
17875631-2	2007	A recombinant proline-rich antigen (rAg2/Pra) has been reported to be a leading vaccine candidate.	Proline	14-21	S100 calcium binding protein A6 (calcyclin)	Mus musculus	41-44
17875631-8	2007	We reveal in this study that C. posadasii produces a homolog of the reported proline-rich antigen, designated Prp2, which shows 69% protein sequence identity and 86% similarity to Ag2/Pra.	Proline	77-84	proline rich protein 2	Rattus norvegicus	110-114
17875631-8	2007	We reveal in this study that C. posadasii produces a homolog of the reported proline-rich antigen, designated Prp2, which shows 69% protein sequence identity and 86% similarity to Ag2/Pra.	Proline	77-84	similar to LOC387763 protein	Rattus norvegicus	180-183
18042461-2	2007	In crystal structures of L3MBTL1 complexes, the monomethyl- and dimethyllysines insert into a narrow and deep cavity of aromatic residue-lined pocket 2, while a proline ring inserts into shallower pocket 1.	Proline	161-168	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	25-32
17786468-3	2007	EARLI1 is a cold responsive Arabidopsis gene that encodes a hybrid proline-rich protein (HyPRP) with a three-domain architecture: a putative signal peptide at the N-terminus, a proline-rich domain (PRD) in the middle, and an 8CM domain at the C-terminus.	Proline	67-74	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein	Arabidopsis thaliana	0-6
17883373-0	2007	A novel serine/proline-rich domain in combination with a transmembrane domain is required for the insertion of AtTic40 into the inner envelope membrane of chloroplasts.	Proline	15-22	hydroxyproline-rich glycoprotein family protein	Arabidopsis thaliana	111-118
17883373-6	2007	We have designated this region a serine/proline-rich (S/P-rich) domain and present a model describing its role in the targeting of AtTic40 to the inner envelope membrane.	Proline	40-47	hydroxyproline-rich glycoprotein family protein	Arabidopsis thaliana	131-138
17763933-6	2007	EB1 and P3HR-1 had non-silent mutations in the sequences leading to the arginine/serine and threonine/proline interchanges at residues 4 and 166, respectively.	Proline	102-109	microtubule associated protein RP/EB family member 1	Homo sapiens	0-3
17923118-0	2007	Stimulation by glutamine and proline of HGF production in hepatic stellate cells.	Proline	29-36	hepatocyte growth factor	Rattus norvegicus	40-43
17923118-4	2007	Treatment with glutamine and proline, as well as leucine, increased HGF levels in the culture medium of a rat hepatic stellate cell clone in a dose-dependent manner.	Proline	29-36	hepatocyte growth factor	Rattus norvegicus	68-71
17923118-6	2007	When rats received injections of glutamine or proline, hepatic and circulating HGF levels increased and peaked around 12h after treatment.	Proline	46-53	hepatocyte growth factor	Rattus norvegicus	79-82
17923118-7	2007	Glutamine and proline may have the potential to stimulate HGF production but the mechanism underlying this stimulation seems not to be through the mTOR-dependent signaling pathway.	Proline	14-21	hepatocyte growth factor	Rattus norvegicus	58-61
17855358-6	2007	We report the first direct evidence that CypB is enzymatically active on CD147, as it is able to accelerate the cis/trans isomerization of the Asp(179)-Pro(180) bond in a CD147-derived peptide.	Proline	152-155	peptidylprolyl isomerase B	Homo sapiens	41-45
17975107-4	2007	The inhibitory region of troponin (Tn)I differs by a single residue, proline at position 112 in ssTnI versus threonine at position 144 in cTnI.	Proline	69-76	troponin I3, cardiac type	Rattus norvegicus	35-39
17855358-6	2007	We report the first direct evidence that CypB is enzymatically active on CD147, as it is able to accelerate the cis/trans isomerization of the Asp(179)-Pro(180) bond in a CD147-derived peptide.	Proline	152-155	basigin (Ok blood group)	Homo sapiens	73-78
17855358-6	2007	We report the first direct evidence that CypB is enzymatically active on CD147, as it is able to accelerate the cis/trans isomerization of the Asp(179)-Pro(180) bond in a CD147-derived peptide.	Proline	152-155	basigin (Ok blood group)	Homo sapiens	171-176
17855365-3	2007	Orthologous genes of FSCB are present in other mammals, including rat and human, and conserved motifs in FSCB include PXXP, proline-rich and extensin-like regions.	Proline	124-131	fibrous sheath CABYR binding protein	Rattus norvegicus	21-25
17855365-3	2007	Orthologous genes of FSCB are present in other mammals, including rat and human, and conserved motifs in FSCB include PXXP, proline-rich and extensin-like regions.	Proline	124-131	fibrous sheath CABYR binding protein	Homo sapiens	105-109
17940506-7	2007	Using mutants of Pfn1 that are defective in binding to either actin or proline-rich ligands, we further show that overexpressed Pfn1 must have a functional actin-binding site to suppress cell motility.	Proline	71-78	profilin 1	Homo sapiens	17-21
17940506-7	2007	Using mutants of Pfn1 that are defective in binding to either actin or proline-rich ligands, we further show that overexpressed Pfn1 must have a functional actin-binding site to suppress cell motility.	Proline	71-78	profilin 1	Homo sapiens	128-132
20641503-0	2004	[(111)In-Diethylenetriaminepentaacetic acid-Pro(1),Tyr(4)]bombesin [(111)In-Diethylenetriaminepentaacetic acid-Pro(1),Tyr(4)]-bombesin ([(111)In-DTPA-Pro(1),Tyr(4)]BN) is a peptide analog of the human gastrin-releasing peptide (GRP) conjugated with (111)In, and it was developed for single-photon emission computed tomography (SPECT) imaging of tumors with overexpressed GRP receptors (GRP-R) (1-3).	Proline	44-47	gastrin releasing peptide	Homo sapiens	58-66
18021396-3	2007	RESULTS: NCU-G1 was found to be a highly conserved nuclear protein rich in proline with a molecular weight of approximately 44 kDa.	Proline	75-82	glycosylated lysosomal membrane protein	Homo sapiens	9-15
17948968-6	2007	The known stabilization of the N-terminal domain of CaM in the context of the intact protein and the known binding affinity of a proline-rich peptide to the SH3 domain in the Fyn construct were successfully quantified using the new protocol.	Proline	129-136	calmodulin 1	Homo sapiens	52-55
17948968-6	2007	The known stabilization of the N-terminal domain of CaM in the context of the intact protein and the known binding affinity of a proline-rich peptide to the SH3 domain in the Fyn construct were successfully quantified using the new protocol.	Proline	129-136	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	175-178
17989286-4	2007	The N-terminal p53 fragment (transactivation and proline-rich domains), which induces apoptosis in non-neuronal cells via the cytosolic/mitochondrial pathway, displayed no apoptogenic activity in neurons.	Proline	49-56	transformation related protein 53, pseudogene	Mus musculus	15-18
20641503-0	2004	[(111)In-Diethylenetriaminepentaacetic acid-Pro(1),Tyr(4)]bombesin [(111)In-Diethylenetriaminepentaacetic acid-Pro(1),Tyr(4)]-bombesin ([(111)In-DTPA-Pro(1),Tyr(4)]BN) is a peptide analog of the human gastrin-releasing peptide (GRP) conjugated with (111)In, and it was developed for single-photon emission computed tomography (SPECT) imaging of tumors with overexpressed GRP receptors (GRP-R) (1-3).	Proline	44-47	gastrin releasing peptide	Homo sapiens	201-226
20641503-0	2004	[(111)In-Diethylenetriaminepentaacetic acid-Pro(1),Tyr(4)]bombesin [(111)In-Diethylenetriaminepentaacetic acid-Pro(1),Tyr(4)]-bombesin ([(111)In-DTPA-Pro(1),Tyr(4)]BN) is a peptide analog of the human gastrin-releasing peptide (GRP) conjugated with (111)In, and it was developed for single-photon emission computed tomography (SPECT) imaging of tumors with overexpressed GRP receptors (GRP-R) (1-3).	Proline	44-47	gastrin releasing peptide	Homo sapiens	228-231
20641503-0	2004	[(111)In-Diethylenetriaminepentaacetic acid-Pro(1),Tyr(4)]bombesin [(111)In-Diethylenetriaminepentaacetic acid-Pro(1),Tyr(4)]-bombesin ([(111)In-DTPA-Pro(1),Tyr(4)]BN) is a peptide analog of the human gastrin-releasing peptide (GRP) conjugated with (111)In, and it was developed for single-photon emission computed tomography (SPECT) imaging of tumors with overexpressed GRP receptors (GRP-R) (1-3).	Proline	44-47	gastrin releasing peptide	Homo sapiens	371-374
20641503-0	2004	[(111)In-Diethylenetriaminepentaacetic acid-Pro(1),Tyr(4)]bombesin [(111)In-Diethylenetriaminepentaacetic acid-Pro(1),Tyr(4)]-bombesin ([(111)In-DTPA-Pro(1),Tyr(4)]BN) is a peptide analog of the human gastrin-releasing peptide (GRP) conjugated with (111)In, and it was developed for single-photon emission computed tomography (SPECT) imaging of tumors with overexpressed GRP receptors (GRP-R) (1-3).	Proline	44-47	gastrin releasing peptide receptor	Homo sapiens	386-391
17981124-5	2007	Hypoxia induces SUMOylation of HIF1alpha, which promotes its binding to a ubiquitin ligase, von Hippel-Lindau (VHL) protein, through a proline hydroxylation-independent mechanism, leading to its ubiquitination and degradation.	Proline	135-142	hypoxia inducible factor 1, alpha subunit	Mus musculus	31-40
18030348-4	2007	We report the identification of Proline-rich Akt substrate (PRAS40) and the hypothetical protein Q6MZQ0/FLJ14213/CAE45978 as new mTOR binding proteins.	Proline	32-39	AKT1 substrate 1	Homo sapiens	60-66
18030348-4	2007	We report the identification of Proline-rich Akt substrate (PRAS40) and the hypothetical protein Q6MZQ0/FLJ14213/CAE45978 as new mTOR binding proteins.	Proline	32-39	mechanistic target of rapamycin kinase	Homo sapiens	129-133
17981124-5	2007	Hypoxia induces SUMOylation of HIF1alpha, which promotes its binding to a ubiquitin ligase, von Hippel-Lindau (VHL) protein, through a proline hydroxylation-independent mechanism, leading to its ubiquitination and degradation.	Proline	135-142	von Hippel-Lindau tumor suppressor	Mus musculus	92-109
17956256-5	2007	The proline-rich domain of ASPP2 is unfolded in its native state, but was not shown to mediate intermolecular interactions.	Proline	4-11	tumor protein p53 binding protein 2	Homo sapiens	27-32
17653713-3	2007	On the other hand, a common polymorphism of the tumour suppressor P53 gene results in either arginine (A) or proline (P) at amino-acid position 72.	Proline	109-116	tumor protein p53	Homo sapiens	66-69
17956256-7	2007	This intramolecular interaction between the unstructured proline-rich domain and the structured Ank-SH3 domains in ASPP2, which is possible due to the unfolded nature of the proline-rich domain, is proposed to have an important role in regulating the intermolecular interactions of ASPP2 with its partner proteins.	Proline	57-64	ankyrin 1	Homo sapiens	96-99
17956256-7	2007	This intramolecular interaction between the unstructured proline-rich domain and the structured Ank-SH3 domains in ASPP2, which is possible due to the unfolded nature of the proline-rich domain, is proposed to have an important role in regulating the intermolecular interactions of ASPP2 with its partner proteins.	Proline	57-64	tumor protein p53 binding protein 2	Homo sapiens	115-120
17956256-7	2007	This intramolecular interaction between the unstructured proline-rich domain and the structured Ank-SH3 domains in ASPP2, which is possible due to the unfolded nature of the proline-rich domain, is proposed to have an important role in regulating the intermolecular interactions of ASPP2 with its partner proteins.	Proline	57-64	tumor protein p53 binding protein 2	Homo sapiens	282-287
17956256-7	2007	This intramolecular interaction between the unstructured proline-rich domain and the structured Ank-SH3 domains in ASPP2, which is possible due to the unfolded nature of the proline-rich domain, is proposed to have an important role in regulating the intermolecular interactions of ASPP2 with its partner proteins.	Proline	174-181	ankyrin 1	Homo sapiens	96-99
17956256-7	2007	This intramolecular interaction between the unstructured proline-rich domain and the structured Ank-SH3 domains in ASPP2, which is possible due to the unfolded nature of the proline-rich domain, is proposed to have an important role in regulating the intermolecular interactions of ASPP2 with its partner proteins.	Proline	174-181	tumor protein p53 binding protein 2	Homo sapiens	115-120
17956256-7	2007	This intramolecular interaction between the unstructured proline-rich domain and the structured Ank-SH3 domains in ASPP2, which is possible due to the unfolded nature of the proline-rich domain, is proposed to have an important role in regulating the intermolecular interactions of ASPP2 with its partner proteins.	Proline	174-181	tumor protein p53 binding protein 2	Homo sapiens	282-287
17944948-7	2007	Bip-[(3)H]Pro uptake into SKPT cells was linear for up to 30 min and pH dependent with a maximum at extracellular pH 6.0.	Proline	10-13	heat shock protein family A (Hsp70) member 5	Homo sapiens	0-3
17974966-2	2007	The BAG3 protein contains a WW domain and a proline-rich region with SH3-binding motifs, suggesting that it may interact with proteins relevant to signal transduction, recruiting Hsp70 to signaling complexes and altering cell responses.	Proline	44-51	BAG cochaperone 3	Homo sapiens	4-8
17974966-2	2007	The BAG3 protein contains a WW domain and a proline-rich region with SH3-binding motifs, suggesting that it may interact with proteins relevant to signal transduction, recruiting Hsp70 to signaling complexes and altering cell responses.	Proline	44-51	heat shock protein family A (Hsp70) member 4	Homo sapiens	179-184
17983358-4	2007	Although, the highest recovery of active maltodextrin glucosidase was achieved through the ATP-mediated GroEL/GroES-assisted refolding of denatured protein, the yield of correctly folded protein from glycerol- or proline-assisted spontaneous refolding process was closer to the chaperonin-assisted refolding.	Proline	213-220	GroEL	Escherichia coli	104-109
17604199-0	2007	Biochemical characterization, homology modeling and docking studies of ornithine delta-aminotransferase--an important enzyme in proline biosynthesis of plants.	Proline	128-135	ornithine aminotransferase	Homo sapiens	71-103
17983358-4	2007	Although, the highest recovery of active maltodextrin glucosidase was achieved through the ATP-mediated GroEL/GroES-assisted refolding of denatured protein, the yield of correctly folded protein from glycerol- or proline-assisted spontaneous refolding process was closer to the chaperonin-assisted refolding.	Proline	213-220	chaperonin GroES	Escherichia coli	110-115
17906334-1	2007	The adaptor protein CD2-binding protein 2 (CD2BP2) confers binding to proline-rich sequences (PRS) via its GYF domain.	Proline	70-77	CD2 cytoplasmic tail binding protein 2	Homo sapiens	20-41
17906334-1	2007	The adaptor protein CD2-binding protein 2 (CD2BP2) confers binding to proline-rich sequences (PRS) via its GYF domain.	Proline	70-77	CD2 cytoplasmic tail binding protein 2	Homo sapiens	43-49
17947633-2	2007	We now show that Fas ligand molecules lacking amino acids 45-54 in the proline-rich region of the cytoplasmic domain fail to costimulate but serve as effective death inducers.	Proline	71-78	Fas ligand	Homo sapiens	17-27
17604199-1	2007	Ornithine delta-aminotransferase (OAT) is an important enzyme in proline biosynthetic pathway and is implicated in salt tolerance in higher plants.	Proline	65-72	ornithine aminotransferase	Homo sapiens	0-32
17604199-1	2007	Ornithine delta-aminotransferase (OAT) is an important enzyme in proline biosynthetic pathway and is implicated in salt tolerance in higher plants.	Proline	65-72	ornithine aminotransferase	Homo sapiens	34-37
17854350-3	2007	Kv1.3, a voltage-gated Shaker potassium channel and tyrosine phosphorylation substrate of IR kinase, contains several proline-rich sequences and a canonical post-synaptic density 95 (PSD-95)/discs large/zO-1 domain (PDZ) recognition motif common to most Shaker family members.	Proline	118-125	potassium voltage-gated channel subfamily A member 3	Homo sapiens	0-5
17854350-5	2007	Through patch-clamp electrophysiology, immunochemistry, and co-immunoprecipitation, we found that while Kv1.3 and PSD-95 alone interact via the canonical C-terminal PDZ recognition motif of the channel, this molecular site of interaction acts to cluster the channels but the PSD-95 SH(3)-guanylate kinase domain functionally modulates Kv1.3 activity via two proline-rich domains in its N- and C-terminal.	Proline	358-365	potassium voltage-gated channel subfamily A member 3	Homo sapiens	104-109
17604199-2	2007	OAT transaminates ornithine to pyrroline 5-carboxylate, which is further catalyzed to proline by pyrroline 5-carboxylate reductase.	Proline	86-93	ornithine aminotransferase	Homo sapiens	0-3
17854350-5	2007	Through patch-clamp electrophysiology, immunochemistry, and co-immunoprecipitation, we found that while Kv1.3 and PSD-95 alone interact via the canonical C-terminal PDZ recognition motif of the channel, this molecular site of interaction acts to cluster the channels but the PSD-95 SH(3)-guanylate kinase domain functionally modulates Kv1.3 activity via two proline-rich domains in its N- and C-terminal.	Proline	358-365	discs large MAGUK scaffold protein 4	Homo sapiens	114-120
17699573-5	2007	Proline-scanning mutagenesis of the predicted helix revealed that single-amino-acid substitutions abolish NSP5 insolubility and hyperphosphorylation.	Proline	0-7	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	106-110
17223225-6	2007	Exogenous proline or betaine increased the activities of all enzymes except MDHAR involved in NaCl-induced ASC-GSH cycle.	Proline	10-17	monodehydroascorbate reductase	Nicotiana tabacum	76-81
17726374-4	2007	We have observed that most known functional KEN boxes are followed by a proline residue and show that this proline plays a role in APC/C(Cdh1) specific degradation.	Proline	72-79	pericentrin	Homo sapiens	44-47
17975075-3	2007	In addition, GABA can induce UGA4 expression when cells are grown with proline but not when they are grown with ammonium.	Proline	71-78	Uga4p	Saccharomyces cerevisiae S288C	29-33
17885091-6	2007	The AGP31 protein shares features with several known and putative nonclassical AGPs from other species: a putative signal peptide, a histidine-rich region near the N terminus followed by a repetitive proline-rich domain, and a cysteine-rich C-terminal PAC (for proline-rich protein and AGP, containing cysteine) domain.	Proline	200-207	arabinogalactan protein 31	Arabidopsis thaliana	4-9
17885091-6	2007	The AGP31 protein shares features with several known and putative nonclassical AGPs from other species: a putative signal peptide, a histidine-rich region near the N terminus followed by a repetitive proline-rich domain, and a cysteine-rich C-terminal PAC (for proline-rich protein and AGP, containing cysteine) domain.	Proline	261-268	arabinogalactan protein 31	Arabidopsis thaliana	4-9
21180121-7	2007	RESULTS: 10(-7) mol/L ET-1 significantly increased A490 value and [3H]-Pro incorporation and decreased NO secretion compared with the control group (P &lt; 0.01).	Proline	71-74	endothelin 1	Rattus norvegicus	22-26
17719007-0	2007	A conserved proline residue in the leucine zipper region of AtbZIP34 and AtbZIP61 in Arabidopsis thaliana interferes with the formation of homodimer.	Proline	12-19	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	60-68
17719007-0	2007	A conserved proline residue in the leucine zipper region of AtbZIP34 and AtbZIP61 in Arabidopsis thaliana interferes with the formation of homodimer.	Proline	12-19	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	73-81
17719007-4	2007	Yeast two-hybrid assay and EMSA showed that AtbZIP34 and AtbZIP61 could not form homodimer while their mutant forms, AtbZIP34m and AtbZIP61m, which the proline residue was replaced by an alanine residue in the zipper region, could form homodimer and bind G-box element.	Proline	152-159	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	44-52
17719007-4	2007	Yeast two-hybrid assay and EMSA showed that AtbZIP34 and AtbZIP61 could not form homodimer while their mutant forms, AtbZIP34m and AtbZIP61m, which the proline residue was replaced by an alanine residue in the zipper region, could form homodimer and bind G-box element.	Proline	152-159	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	57-65
17719007-4	2007	Yeast two-hybrid assay and EMSA showed that AtbZIP34 and AtbZIP61 could not form homodimer while their mutant forms, AtbZIP34m and AtbZIP61m, which the proline residue was replaced by an alanine residue in the zipper region, could form homodimer and bind G-box element.	Proline	152-159	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	117-125
17719007-4	2007	Yeast two-hybrid assay and EMSA showed that AtbZIP34 and AtbZIP61 could not form homodimer while their mutant forms, AtbZIP34m and AtbZIP61m, which the proline residue was replaced by an alanine residue in the zipper region, could form homodimer and bind G-box element.	Proline	152-159	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	131-139
17904692-1	2007	Prolyl oligopeptidase (POP, EC 3.4.21.26) is a member of a family of serine peptidases with post-proline cleaving activity towards peptides.	Proline	97-104	prolyl endopeptidase	Homo sapiens	0-21
17915942-4	2007	Although the sequence of the pol mu BRCT domain has some unique characteristics, particularly the presence of &gt;10% proline residues, it forms the characteristic alphabetaalpha sandwich, in which three alpha helices are arrayed around a central four-stranded beta-sheet.	Proline	118-125	DNA polymerase mu	Homo sapiens	29-35
17726031-7	2007	Furthermore, recombinant P4H-TM hydroxylated the two critical prolines in HIF-1alpha ODDD in vitro, with a preference for the C-terminal proline, whereas it did not hydroxylate any prolines in recombinant type I procollagen chains.	Proline	62-70	prolyl 4-hydroxylase, transmembrane	Homo sapiens	25-31
17726031-7	2007	Furthermore, recombinant P4H-TM hydroxylated the two critical prolines in HIF-1alpha ODDD in vitro, with a preference for the C-terminal proline, whereas it did not hydroxylate any prolines in recombinant type I procollagen chains.	Proline	62-69	prolyl 4-hydroxylase, transmembrane	Homo sapiens	25-31
17726374-4	2007	We have observed that most known functional KEN boxes are followed by a proline residue and show that this proline plays a role in APC/C(Cdh1) specific degradation.	Proline	72-79	cadherin 1	Homo sapiens	137-141
17726374-4	2007	We have observed that most known functional KEN boxes are followed by a proline residue and show that this proline plays a role in APC/C(Cdh1) specific degradation.	Proline	107-114	pericentrin	Homo sapiens	44-47
17954263-0	2007	Proline homozygosity in codon 72 of TP53 is a factor of susceptibility to nasopharyngeal carcinoma in Tunisia.	Proline	0-7	tumor protein p53	Homo sapiens	36-40
17954263-1	2007	A common polymorphism at codon 72 of TP53, the gene encoding the tumor suppressor protein p53, encodes either arginine or proline.	Proline	122-129	tumor protein p53	Homo sapiens	37-41
17726374-4	2007	We have observed that most known functional KEN boxes are followed by a proline residue and show that this proline plays a role in APC/C(Cdh1) specific degradation.	Proline	107-114	cadherin 1	Homo sapiens	137-141
17954263-1	2007	A common polymorphism at codon 72 of TP53, the gene encoding the tumor suppressor protein p53, encodes either arginine or proline.	Proline	122-129	tumor protein p53	Homo sapiens	90-93
17702753-5	2007	Amino acids 425-671 of STIM1, which contain a serine-proline-rich region, are important for the correct targeting of the STIM1 cluster to the cell periphery after calcium store depletion.	Proline	53-60	stromal interaction molecule 1	Homo sapiens	23-28
17765920-4	2007	The ubiquitin binding surface of the Sla1 SH3 domain overlaps substantially with the canonical binding surface for proline-rich ligands.	Proline	115-122	cytoskeletal protein-binding protein SLA1	Saccharomyces cerevisiae S288C	37-41
17923090-3	2007	By binding to IFNalphaR2 within the region where two adjacent proline boxes bear phospho-Ser364 and phospho-Ser384, CBP acetylates IFNalphaR2 on Lys399, which in turn serves as the docking site for interferon regulatory factor 9 (IRF9).	Proline	62-69	CREB binding protein	Homo sapiens	116-119
17923090-3	2007	By binding to IFNalphaR2 within the region where two adjacent proline boxes bear phospho-Ser364 and phospho-Ser384, CBP acetylates IFNalphaR2 on Lys399, which in turn serves as the docking site for interferon regulatory factor 9 (IRF9).	Proline	62-69	interferon regulatory factor 9	Homo sapiens	198-228
17923090-3	2007	By binding to IFNalphaR2 within the region where two adjacent proline boxes bear phospho-Ser364 and phospho-Ser384, CBP acetylates IFNalphaR2 on Lys399, which in turn serves as the docking site for interferon regulatory factor 9 (IRF9).	Proline	62-69	interferon regulatory factor 9	Homo sapiens	230-234
17702753-5	2007	Amino acids 425-671 of STIM1, which contain a serine-proline-rich region, are important for the correct targeting of the STIM1 cluster to the cell periphery after calcium store depletion.	Proline	53-60	stromal interaction molecule 1	Homo sapiens	121-126
17597182-12	2007	This mutation at codon 1,315 represents an already described PTCH germline polymorphism and results in a heterozygous Pro to Leu substitution in the tumor.	Proline	118-121	patched 1	Homo sapiens	61-65
17845900-6	2007	Efficacy of a nutrient mixture (NM) containing lysine, proline, ascorbic acid, and green tea extract has been demonstrated for reducing VEGF and MMPs secretion by various cells.	Proline	55-62	vascular endothelial growth factor A	Homo sapiens	136-140
17579843-5	2007	The result of the BALF proteome analysis show the presence of several isoforms of SP-A, in which an N-non-glycosylierte form and several proline hydroxylations were identified.	Proline	137-144	surfactant protein A1	Homo sapiens	82-86
17412540-1	2007	Hyperprolinemia type I (HPI) results from a deficiency of proline oxidase (POX), involved in the first step in the conversion of proline to glutamate.	Proline	5-12	proline dehydrogenase 1	Homo sapiens	58-73
17412540-1	2007	Hyperprolinemia type I (HPI) results from a deficiency of proline oxidase (POX), involved in the first step in the conversion of proline to glutamate.	Proline	5-12	proline dehydrogenase 1	Homo sapiens	75-78
17897208-3	2007	Tryptophan and proline were more abundant in the peptides of phages from competitive elution with FLO11 cells than in those from competitive elution with flo11Delta cells.	Proline	15-22	Flo11p	Saccharomyces cerevisiae S288C	98-103
17897208-4	2007	Furthermore, two phages with hydrophobic peptides containing 1 or 2 tryptophan, and 3 or 5 proline, residues inhibited the adhesion of FLO11 cells to PolySorp more than a phage with a hydrophobic peptide containing no tryptophan and only two proline residues.	Proline	91-98	Flo11p	Saccharomyces cerevisiae S288C	135-140
17897208-4	2007	Furthermore, two phages with hydrophobic peptides containing 1 or 2 tryptophan, and 3 or 5 proline, residues inhibited the adhesion of FLO11 cells to PolySorp more than a phage with a hydrophobic peptide containing no tryptophan and only two proline residues.	Proline	242-249	Flo11p	Saccharomyces cerevisiae S288C	135-140
17897208-5	2007	CONCLUSIONS: Our results suggest a key role of tryptophan and proline in the hydrophobic interactions between Flo11p on the S. cerevisiae cell surface and the PolySorp surface.	Proline	62-69	Flo11p	Saccharomyces cerevisiae S288C	110-116
17720532-4	2007	Proline-directed serine/threonine kinase, Dyrk1A, is mapped within DSCR, and involved in the control of cell growth and postembryonic neurogenesis.	Proline	0-7	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	42-48
17676345-1	2007	Dipeptidyl peptidase IV (DPP-IV) deactivates the incretin hormones GLP-1 and GIP by cleaving the penultimate proline or alanine from the N-terminal (P1-position) of the peptide.	Proline	109-116	dipeptidyl peptidase 4	Homo sapiens	0-23
17676345-1	2007	Dipeptidyl peptidase IV (DPP-IV) deactivates the incretin hormones GLP-1 and GIP by cleaving the penultimate proline or alanine from the N-terminal (P1-position) of the peptide.	Proline	109-116	dipeptidyl peptidase 4	Homo sapiens	25-31
17676345-1	2007	Dipeptidyl peptidase IV (DPP-IV) deactivates the incretin hormones GLP-1 and GIP by cleaving the penultimate proline or alanine from the N-terminal (P1-position) of the peptide.	Proline	109-116	glucagon like peptide 1 receptor	Homo sapiens	67-72
17676345-1	2007	Dipeptidyl peptidase IV (DPP-IV) deactivates the incretin hormones GLP-1 and GIP by cleaving the penultimate proline or alanine from the N-terminal (P1-position) of the peptide.	Proline	109-116	gastric inhibitory polypeptide	Homo sapiens	77-80
17671168-1	2007	The proline-directed kinase Cdk5 plays a role in several aspects of neuronal development.	Proline	4-11	Cyclin-dependent-like kinase 5	Caenorhabditis elegans	28-32
17720532-4	2007	Proline-directed serine/threonine kinase, Dyrk1A, is mapped within DSCR, and involved in the control of cell growth and postembryonic neurogenesis.	Proline	0-7	Down syndrome chromosome region	Homo sapiens	67-71
17906639-5	2007	Accordingly, tumor-associated mutations at Pin1-binding residues within the p53 proline-rich domain hamper acetylation of p53 by p300.	Proline	80-87	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	43-47
17906639-5	2007	Accordingly, tumor-associated mutations at Pin1-binding residues within the p53 proline-rich domain hamper acetylation of p53 by p300.	Proline	80-87	tumor protein p53	Homo sapiens	76-79
17906639-5	2007	Accordingly, tumor-associated mutations at Pin1-binding residues within the p53 proline-rich domain hamper acetylation of p53 by p300.	Proline	80-87	tumor protein p53	Homo sapiens	122-125
17906639-5	2007	Accordingly, tumor-associated mutations at Pin1-binding residues within the p53 proline-rich domain hamper acetylation of p53 by p300.	Proline	80-87	E1A binding protein p300	Homo sapiens	129-133
17652093-3	2007	We demonstrate that this interaction is mediated in part by the beta PIX-SH3 domain binding to a proline-rich stretch of AIP4.	Proline	97-104	Rho guanine nucleotide exchange factor 7	Homo sapiens	64-72
17767549-0	2007	Predisposition to HPV16/18-related cervical cancer because of proline homozygosity at codon 72 of p53 among Indian women is influenced by HLA-B*07 and homozygosity of HLA-DQB1*03.	Proline	62-69	tumor protein p53	Homo sapiens	98-101
17767549-0	2007	Predisposition to HPV16/18-related cervical cancer because of proline homozygosity at codon 72 of p53 among Indian women is influenced by HLA-B*07 and homozygosity of HLA-DQB1*03.	Proline	62-69	major histocompatibility complex, class I, B	Homo sapiens	138-143
17767549-0	2007	Predisposition to HPV16/18-related cervical cancer because of proline homozygosity at codon 72 of p53 among Indian women is influenced by HLA-B*07 and homozygosity of HLA-DQB1*03.	Proline	62-69	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	167-175
17937912-3	2007	Here, we report the structural model of full-length pro-MMP-9 and, in particular, the molecular character of its unique proline-rich and heavily O-glycosylated (OG) domain.	Proline	120-127	matrix metallopeptidase 9	Homo sapiens	56-61
17652093-3	2007	We demonstrate that this interaction is mediated in part by the beta PIX-SH3 domain binding to a proline-rich stretch of AIP4.	Proline	97-104	itchy E3 ubiquitin protein ligase	Homo sapiens	121-125
17579185-4	2007	HIF in turn is regulated through its alpha subunit, which under normoxic conditions is hydroxylated on specific prolines and targeted for degradation by the von Hippel Lindau (VHL) protein.	Proline	112-120	von Hippel-Lindau tumor suppressor	Homo sapiens	157-174
17761170-3	2007	The intracellular domain of FasL contains consensus sequences for phosphorylation and an extended proline rich region, which regulate its surface expression through undetermined mechanism(s).	Proline	98-105	Fas ligand	Homo sapiens	28-32
17579185-4	2007	HIF in turn is regulated through its alpha subunit, which under normoxic conditions is hydroxylated on specific prolines and targeted for degradation by the von Hippel Lindau (VHL) protein.	Proline	112-120	von Hippel-Lindau tumor suppressor	Homo sapiens	176-179
17714866-3	2007	All patients and asymptomatic carriers from this family, but none of the normal population controls, showed a T-C transition at position 266 in codon 89 of exon 2 of connexin 32, resulting in a leucine to proline (L89P) exchange.	Proline	205-212	gap junction protein beta 1	Homo sapiens	166-177
17908042-2	2007	They are based on neuroblastoma cell lines (N2a) that inducibly express different forms of the repeat domain of tau (tau(RD)), e.g. the 4-repeat domain of tau with the wild-type sequence, the repeat domain with the DeltaK280 mutation ("pro-aggregation mutant"), or the repeat domain with DeltaK280 and two proline point mutations ("anti-aggregation mutant").	Proline	306-313	microtubule associated protein tau	Homo sapiens	112-115
17468230-8	2007	This seeming paradox suggests that conformational searching of Tbeta4, and particularly cis-trans isomerization of proline residues, contributes to the slow association rate constant of Tbeta4, and to the stability of the hydrophobic contacts associated with strong actin binding.	Proline	115-122	thymosin beta 4 X-linked	Homo sapiens	186-192
17854747-9	2007	The beta2-GPI transcriptional signal of 1.5 kb was detected in Northern blot analysis and its 326-amino-acid sequence was found to be one of the most proline-rich eukaryotic proteins.	Proline	150-157	apolipoprotein H	Homo sapiens	4-13
17696407-5	2007	We have used mass spectrometry, domain and peptide arrays, and surface plasmon resonance to identify binding partners for a conserved proline-rich sequence (PPLP) in the K15 cytoplasmic tail.	Proline	134-141	keratin 15	Homo sapiens	170-173
17925189-5	2007	Investigation of recessive forms of OI particularly reported among South African blacks have revealed mutations involving both the CRTAP gene and the leucine proline-enriched proteoglycan 1 (LEPRE1) gene, each involved in collagen proline-3 hydroxylation.	Proline	158-165	prolyl 3-hydroxylase 1	Homo sapiens	191-197
17631635-11	2007	Additionally, the substitution of T352 with a proline inhibited p65 cleavage.	Proline	46-53	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	64-67
17505842-7	2007	RESULTS: We found that the level of endogenous FasL, but not Fas receptor, was increased at a permissive temperature with delayed kinetics when compared with p21WAF1 expression, but was coincident with p53-induced apoptosis, whereas an apoptosis-defective mutant p53, which lacks the PxxP region (P: Proline, x: any amino acid), failed to induce FasL expression and hence apoptosis.	Proline	300-307	Fas ligand	Homo sapiens	47-51
17483953-6	2007	We found that the transgenic tall fescue showed increased resistance to drought and accumulated high level of proline, indicating ability of the CBF3 gene to induce stress related response in tall fescue.	Proline	110-117	dehydration response element B1A	Arabidopsis thaliana	145-149
17712599-6	2007	The calculations led to a Phe6.44/Trp6.48/Phe6.52-switch and linearization of the proline kinked transmembrane helix VI during receptor activation.	Proline	82-89	short transient receptor potential channel 6	Cavia porcellus	34-38
17394551-1	2007	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase that plays important roles in various neuronal activities, including neuronal migration, synaptic activity, and neuronal cell death.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
17394551-1	2007	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase that plays important roles in various neuronal activities, including neuronal migration, synaptic activity, and neuronal cell death.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
17620415-2	2007	We have identified the proline-rich region and RRM1 domains of poly(A) binding protein (PAB1) as necessary for CCR4 deadenylation.	Proline	23-30	polyadenylate-binding protein	Saccharomyces cerevisiae S288C	88-92
17620415-2	2007	We have identified the proline-rich region and RRM1 domains of poly(A) binding protein (PAB1) as necessary for CCR4 deadenylation.	Proline	23-30	CCR4-NOT core exoribonuclease subunit CCR4	Saccharomyces cerevisiae S288C	111-115
17553868-0	2007	Proline 35 of human immunodeficiency virus type 1 (HIV-1) Vpr regulates the integrity of the N-terminal helix and the incorporation of Vpr into virus particles and supports the replication of R5-tropic HIV-1 in human lymphoid tissue ex vivo.	Proline	0-7	Vpr	Human immunodeficiency virus 1	58-61
17553868-3	2007	(1)H nuclear magnetic resonance data suggest that mutation of Pro-35 causes a conformational change in the hydrophobic core of the molecule, whose integrity is required for the encapsidation of Vpr, and thus, Pro-35 supports the replication of R5-tropic HIV-1 in HLT.	Proline	62-65	Vpr	Human immunodeficiency virus 1	194-197
17553868-3	2007	(1)H nuclear magnetic resonance data suggest that mutation of Pro-35 causes a conformational change in the hydrophobic core of the molecule, whose integrity is required for the encapsidation of Vpr, and thus, Pro-35 supports the replication of R5-tropic HIV-1 in HLT.	Proline	209-212	Vpr	Human immunodeficiency virus 1	194-197
17626162-4	2007	Although localization of kinases and phosphatases is certainly implicated, another possibility involves Pin1 modulation of phosphorylation of the proline-directed serine/threonine residues.	Proline	146-153	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	104-108
17626162-5	2007	Pin1, a prolyl isomerase, selectively binds to phosphorylated proline-directed serine/threonine residues in target proteins and isomerizes cis isomers to more stable trans configurations.	Proline	62-69	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
17626162-9	2007	Thus, isomerization of lys-ser-pro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation, which suggests that Pin1 inhibition may be an attractive therapeutic target to reduce pathological accumulations of p-NF-H.	Proline	31-34	neurofilament heavy chain	Homo sapiens	72-76
17626162-9	2007	Thus, isomerization of lys-ser-pro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation, which suggests that Pin1 inhibition may be an attractive therapeutic target to reduce pathological accumulations of p-NF-H.	Proline	31-34	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	93-97
17626162-9	2007	Thus, isomerization of lys-ser-pro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation, which suggests that Pin1 inhibition may be an attractive therapeutic target to reduce pathological accumulations of p-NF-H.	Proline	31-34	neurofilament heavy chain	Homo sapiens	111-115
17626162-9	2007	Thus, isomerization of lys-ser-pro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation, which suggests that Pin1 inhibition may be an attractive therapeutic target to reduce pathological accumulations of p-NF-H.	Proline	31-34	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	153-157
17626162-9	2007	Thus, isomerization of lys-ser-pro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation, which suggests that Pin1 inhibition may be an attractive therapeutic target to reduce pathological accumulations of p-NF-H.	Proline	31-34	neurofilament heavy chain	Homo sapiens	111-115
17540579-3	2007	ALS8 is caused by a substitution of a proline by a serine in the Vesicle-Associated Membrane Protein-Associated protein-B/C (VAP-B/C).	Proline	38-45	VAMP associated protein B and C	Homo sapiens	0-4
17702861-3	2007	Using CTLA-4-deficient mice expressing CD28 molecules with various point mutations in the CD28 cytosolic tail, the present study documents that in vivo costimulation for induction of autoimmune disease strictly requires an intact C-terminal proline motif that promotes lymphocyte-specific protein tyrosine kinase Lck binding to the CD28 cytosolic tail, because point mutations in C-terminal proline residues (Pro-187 and Pro-190) completely prevented disease induction.	Proline	241-248	CD28 antigen	Mus musculus	39-43
17540579-3	2007	ALS8 is caused by a substitution of a proline by a serine in the Vesicle-Associated Membrane Protein-Associated protein-B/C (VAP-B/C).	Proline	38-45	VAMP associated protein B and C	Homo sapiens	65-123
17597065-4	2007	We found that substitution of residues 173-175 and particularly Pro(174) to alanines reduces the EGF-induced ERK2 phosphorylation, without modifying its in vitro phosphorylation by MEK1.	Proline	64-67	mitogen-activated protein kinase 1	Homo sapiens	109-113
17540579-3	2007	ALS8 is caused by a substitution of a proline by a serine in the Vesicle-Associated Membrane Protein-Associated protein-B/C (VAP-B/C).	Proline	38-45	VAMP associated protein B and C	Homo sapiens	125-132
17603008-2	2007	hGS2 and its rat orthologue, rGS2, are 80% homologous and share a proline insertion at residue 56 and a C-terminal truncation compared to the hGS2 paralogues.	Proline	66-73	patatin like phospholipase domain containing 4	Homo sapiens	0-4
17603008-2	2007	hGS2 and its rat orthologue, rGS2, are 80% homologous and share a proline insertion at residue 56 and a C-terminal truncation compared to the hGS2 paralogues.	Proline	66-73	regulator of G-protein signaling 2	Rattus norvegicus	29-33
17597155-4	2007	It is widely believed that the highly charged region interacts with actin, while the Pro/Ala-rich sequence forms a rigid tether that bridges the approximately 9 nm distance between the myosin lever arm and the thin filament.	Proline	85-88	myosin heavy chain 14	Homo sapiens	185-191
17597155-7	2007	Given that SH3 domains are known to bind proline-rich ligands, we suggest that the N-terminal extension of ELC interacts with actin and modulates myosin kinetics by binding to the SH3 domain during the ATPase cycle.	Proline	41-48	C-C motif chemokine ligand 19	Homo sapiens	107-110
17597155-7	2007	Given that SH3 domains are known to bind proline-rich ligands, we suggest that the N-terminal extension of ELC interacts with actin and modulates myosin kinetics by binding to the SH3 domain during the ATPase cycle.	Proline	41-48	myosin heavy chain 14	Homo sapiens	146-152
17702861-3	2007	Using CTLA-4-deficient mice expressing CD28 molecules with various point mutations in the CD28 cytosolic tail, the present study documents that in vivo costimulation for induction of autoimmune disease strictly requires an intact C-terminal proline motif that promotes lymphocyte-specific protein tyrosine kinase Lck binding to the CD28 cytosolic tail, because point mutations in C-terminal proline residues (Pro-187 and Pro-190) completely prevented disease induction.	Proline	241-248	CD28 antigen	Mus musculus	90-94
17561513-3	2007	Although both N-terminally truncated and full-length MCL1 contain sequences enriched in proline, glutamic acid, serine, and threonine and were susceptible to proteasomal degradation, the truncated form decayed less rapidly and was maintained for an extended period in the presence of ERK activation.	Proline	88-95	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	53-57
17702861-3	2007	Using CTLA-4-deficient mice expressing CD28 molecules with various point mutations in the CD28 cytosolic tail, the present study documents that in vivo costimulation for induction of autoimmune disease strictly requires an intact C-terminal proline motif that promotes lymphocyte-specific protein tyrosine kinase Lck binding to the CD28 cytosolic tail, because point mutations in C-terminal proline residues (Pro-187 and Pro-190) completely prevented disease induction.	Proline	241-248	lymphocyte protein tyrosine kinase	Mus musculus	313-316
17702861-3	2007	Using CTLA-4-deficient mice expressing CD28 molecules with various point mutations in the CD28 cytosolic tail, the present study documents that in vivo costimulation for induction of autoimmune disease strictly requires an intact C-terminal proline motif that promotes lymphocyte-specific protein tyrosine kinase Lck binding to the CD28 cytosolic tail, because point mutations in C-terminal proline residues (Pro-187 and Pro-190) completely prevented disease induction.	Proline	241-248	CD28 antigen	Mus musculus	90-94
17702861-3	2007	Using CTLA-4-deficient mice expressing CD28 molecules with various point mutations in the CD28 cytosolic tail, the present study documents that in vivo costimulation for induction of autoimmune disease strictly requires an intact C-terminal proline motif that promotes lymphocyte-specific protein tyrosine kinase Lck binding to the CD28 cytosolic tail, because point mutations in C-terminal proline residues (Pro-187 and Pro-190) completely prevented disease induction.	Proline	391-398	CD28 antigen	Mus musculus	90-94
17702861-3	2007	Using CTLA-4-deficient mice expressing CD28 molecules with various point mutations in the CD28 cytosolic tail, the present study documents that in vivo costimulation for induction of autoimmune disease strictly requires an intact C-terminal proline motif that promotes lymphocyte-specific protein tyrosine kinase Lck binding to the CD28 cytosolic tail, because point mutations in C-terminal proline residues (Pro-187 and Pro-190) completely prevented disease induction.	Proline	391-398	CD28 antigen	Mus musculus	90-94
17702861-5	2007	Thus, in vivo CD28 costimulation for induction of autoimmune disease is strictly and specifically dependent on an intact C-terminal proline motif that serves as a lymphocyte-specific protein tyrosine Lck kinase binding site in the CD28 cytosolic tail.	Proline	132-139	CD28 antigen	Mus musculus	14-18
17702861-5	2007	Thus, in vivo CD28 costimulation for induction of autoimmune disease is strictly and specifically dependent on an intact C-terminal proline motif that serves as a lymphocyte-specific protein tyrosine Lck kinase binding site in the CD28 cytosolic tail.	Proline	132-139	lymphocyte protein tyrosine kinase	Mus musculus	200-203
17702861-5	2007	Thus, in vivo CD28 costimulation for induction of autoimmune disease is strictly and specifically dependent on an intact C-terminal proline motif that serves as a lymphocyte-specific protein tyrosine Lck kinase binding site in the CD28 cytosolic tail.	Proline	132-139	CD28 antigen	Mus musculus	231-235
17519236-4	2007	We have generated a non-IGF-binding IGFBP-6 mutant by substituting Ala for four amino acid residues (Pro(93)/Leu(94)/Leu(97)/Leu(98)) in its N-domain IGF-binding site.	Proline	101-104	insulin like growth factor binding protein 6	Homo sapiens	36-43
17666436-8	2007	ZO-1 directly interacts with the serine- and proline-rich region of shroom2 in vitro.	Proline	45-52	tight junction protein 1	Canis lupus familiaris	0-4
17666436-8	2007	ZO-1 directly interacts with the serine- and proline-rich region of shroom2 in vitro.	Proline	45-52	shroom family member 2	Canis lupus familiaris	68-75
17544362-2	2007	They are inhibited by ubiquitin protein ligases, such as Nedd4 and Nedd4-2, which bind to proline-rich motifs (PY motifs) present in the C-termini of ENaC subunits.	Proline	90-97	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	57-62
17917856-1	2007	Extensive hydrogen bonding of dyes to connective tissue fibers is made possible by the high content of the amino acids proline and glycine in elastin and collagens.	Proline	119-126	elastin	Homo sapiens	142-149
17544362-2	2007	They are inhibited by ubiquitin protein ligases, such as Nedd4 and Nedd4-2, which bind to proline-rich motifs (PY motifs) present in the C-termini of ENaC subunits.	Proline	90-97	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	67-74
17526057-1	2007	Since the isolation of cyclin-dependent kinase 5 (Cdk5), this proline-directed serine/threonine kinase has been demonstrated as an important regulator of neuronal migration, neuronal survival and synaptic functions.	Proline	62-69	cyclin dependent kinase 5	Homo sapiens	23-48
17526057-1	2007	Since the isolation of cyclin-dependent kinase 5 (Cdk5), this proline-directed serine/threonine kinase has been demonstrated as an important regulator of neuronal migration, neuronal survival and synaptic functions.	Proline	62-69	cyclin dependent kinase 5	Homo sapiens	50-54
17494643-0	2007	Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function.	Proline	42-49	ATP binding cassette subfamily C member 1	Homo sapiens	61-65
17691904-6	2007	Pro-inflammatory stimuli trigger the activation of an intracellular signal transduction network comprising proline-directed serine/threonine kinases, and their downstream transcription factors, resulting in an inappropriate induction of COX-2.	Proline	107-114	prostaglandin-endoperoxide synthase 2	Homo sapiens	237-242
17683371-1	2007	Herein, we report the discovery of novel, proline-based factor Xa inhibitors containing a neutral P1 chlorophenyl pharmacophore.	Proline	42-49	coagulation factor X	Homo sapiens	56-65
17494643-0	2007	Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function.	Proline	42-49	ATP binding cassette subfamily C member 2	Homo sapiens	67-71
17494643-0	2007	Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function.	Proline	42-49	ATP binding cassette subfamily C member 3	Homo sapiens	77-81
17494643-4	2007	To determine whether the functional importance of MRP1-Pro(1150) is conserved, the analogous Pro(1158) and Pro(1147) residues in the MRP2 and MRP3 transporters, respectively, were mutated to Ala.	Proline	55-58	ATP binding cassette subfamily C member 1	Homo sapiens	50-54
17522383-1	2007	The yeast endocytic scaffold Pan1 contains an uncharacterized proline-rich domain (PRD) at its carboxy (C)-terminus.	Proline	62-69	Pan1p	Saccharomyces cerevisiae S288C	29-33
17287960-3	2007	We demonstrated successful scintigraphic visualisation of BN receptor-positive tumours in preclinical studies using the radiolabelled BN analogue [(111)In-DTPA-Pro(1),Tyr(4)]BN.	Proline	160-163	gastrin releasing peptide	Homo sapiens	134-136
17287960-3	2007	We demonstrated successful scintigraphic visualisation of BN receptor-positive tumours in preclinical studies using the radiolabelled BN analogue [(111)In-DTPA-Pro(1),Tyr(4)]BN.	Proline	160-163	gastrin releasing peptide	Homo sapiens	134-136
17701549-4	2007	A dipeptide motif of cysteine and proline (CP motif) in Bach1 is essential for the heme-mediated regulation.	Proline	34-41	BTB domain and CNC homolog 1	Homo sapiens	56-61
17914241-7	2007	Occurrence of proline was very high for calpain 10 gene and glucose transporter.	Proline	14-21	calpain 10	Homo sapiens	40-50
17318613-3	2007	This C1019T polymorphism causes a proline-to-serine substitution (P319S) in the regulatory C terminal tail of Cx37, a protein that is expressed in the vascular endothelium as well as in monocytes and macrophages.	Proline	34-41	gap junction protein alpha 4	Homo sapiens	110-114
17634259-5	2007	Following resistance exercise, 4E-BP1 phosphorylation was reduced to a greater extent in the CHO treatment (-48 +/- 7%) than in the CHO+PRO treatment (-15 +/- 14%, P &lt; 0.01).	Proline	136-139	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	31-37
17634259-9	2007	During recovery, S6K1 phosphorylation at T(389) remained higher in CHO+PRO than in CHO (P &lt; 0.05).	Proline	71-74	ribosomal protein S6 kinase B1	Homo sapiens	17-21
17496163-10	2007	Finally, deletion of the proline-rich SULT2B1 carboxyl terminus resulted in intracellular protein aggregate formation and accelerated degradation of the truncated protein.	Proline	25-32	sulfotransferase family 2B member 1	Homo sapiens	38-45
17510209-6	2007	Replacing the mbeta2AR proline (-1) with a leucine generated a gain-of-function mutation, mbeta2AR-P417L, with a rescued ability to bind NSF, faster internalization and recycling than the mbeta2AR, and a significant enhancement in Gi signaling, which mimics the hbeta2AR.	Proline	23-30	N-ethylmaleimide sensitive fusion protein	Mus musculus	137-140
17287960-3	2007	We demonstrated successful scintigraphic visualisation of BN receptor-positive tumours in preclinical studies using the radiolabelled BN analogue [(111)In-DTPA-Pro(1),Tyr(4)]BN.	Proline	160-163	gastrin releasing peptide	Homo sapiens	58-60
17635183-12	2007	Maximal exercise HR and DBP were also significantly lower in Ser/Pro genotype carriers in comparison with Ser/Ser genotype carriers.	Proline	65-68	D-box binding PAR bZIP transcription factor	Homo sapiens	24-27
17614368-6	2007	Instead, we found that the mutation of either one of the two lysine residues in the carboxyl terminus of PS2 or the proline residues in the highly conserved PALP motif in this region results in destabilization of the mutant PS2 polypeptides because of increased degradation by the proteasome.	Proline	116-123	presenilin 2	Homo sapiens	224-227
17437541-0	2007	Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis.	Proline	45-52	protein kinase C and casein kinase substrate in neurons 1	Homo sapiens	0-10
17540596-3	2007	Here, we show that the osmolyte chemical chaperones glycerol, trimethylamine-N-oxide, dimethylsulfoxide, proline or sorbitol, when added to yeast media, allows growth on cysteine-free media and causes increased enzyme activity from I278T and three other mutant CBS proteins.	Proline	105-112	cystathionine beta-synthase	Homo sapiens	261-264
17543336-4	2007	Abl-binding proteins bound to a proline-rich region of PAK-2 located in the regulatory N terminus.	Proline	32-39	p21 (RAC1) activated kinase 2	Homo sapiens	55-60
17535812-4	2007	Structure-function analysis demonstrates that, in this cellular model, the SH2, proline-rich, and pleckstrin homology domains of Grb10, as well as its Akt phosphorylation site and consequent binding by 14-3-3, are all necessary for its anti-apoptotic functions.	Proline	80-87	growth factor receptor bound protein 10	Mus musculus	129-134
17640901-6	2007	Overall, state change seems to occur by attachment of a hydrophobic triplet (Trp-546, Phe-547, and Pro-548) of myosin to an actin conduit with a hydrophobic guiding rail (Ile-341, Ile-345, Leu-349, and Phe-352) and the subsequent linear movement of the triplet along the rail.	Proline	99-102	myosin heavy chain 14	Homo sapiens	111-117
17412315-5	2007	Mechanistically, NO blocks PHD activity and attenuates proline hydroxylation of HIF-1alpha.	Proline	55-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
17574218-1	2007	The glucocorticoid-induced leucine zipper (GILZ) is a 137 amino acid protein, which was originally identified as a dexamethasone-inducible gene, and is characterized by a leucine zipper domain, an N-terminal domain and a C-terminal proline and glutamic acid rich domain.	Proline	232-239	TSC22 domain family, member 3	Mus musculus	4-41
17574218-1	2007	The glucocorticoid-induced leucine zipper (GILZ) is a 137 amino acid protein, which was originally identified as a dexamethasone-inducible gene, and is characterized by a leucine zipper domain, an N-terminal domain and a C-terminal proline and glutamic acid rich domain.	Proline	232-239	TSC22 domain family, member 3	Mus musculus	43-47
17640355-5	2007	C. bactrianus ferus together with the rest of mammalian species do not share a triplet nucleotide insertion (GCC) that encodes a proline residue found only in the nd1 gene of the New World camelid Lama pacos.	Proline	129-136	guanylate cyclase 2C	Homo sapiens	109-112
17640355-5	2007	C. bactrianus ferus together with the rest of mammalian species do not share a triplet nucleotide insertion (GCC) that encodes a proline residue found only in the nd1 gene of the New World camelid Lama pacos.	Proline	129-136	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	163-166
17606903-5	2007	The PAR4 fragment, traced entirely in the electron density maps except for five C-terminal residues, clamps Trp-60d, Tyr-60a, and the aryl-binding site of thrombin with Pro-56 and Pro-58 at the P2 and P4 positions and engages the primary specificity pocket with Arg-59.	Proline	180-183	coagulation factor II (thrombin) receptor-like 3	Mus musculus	4-8
17517883-0	2007	The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.	Proline	4-11	AKT1 substrate 1	Homo sapiens	42-48
17517883-0	2007	The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.	Proline	4-11	mechanistic target of rapamycin kinase	Homo sapiens	82-111
17630507-1	2007	Prolyl 3-hydroxylase 1 (P3H1), cartilage-associated protein (CRTAP) and cyclophilin B (CyPB) form a complex in the endoplasmic reticulum which is responsible for 3-hydroxylation of a limited number of proline residues in types I, II and V collagens.	Proline	201-208	prolyl 3-hydroxylase 1	Homo sapiens	0-22
17630507-1	2007	Prolyl 3-hydroxylase 1 (P3H1), cartilage-associated protein (CRTAP) and cyclophilin B (CyPB) form a complex in the endoplasmic reticulum which is responsible for 3-hydroxylation of a limited number of proline residues in types I, II and V collagens.	Proline	201-208	prolyl 3-hydroxylase 1	Homo sapiens	24-28
17630507-1	2007	Prolyl 3-hydroxylase 1 (P3H1), cartilage-associated protein (CRTAP) and cyclophilin B (CyPB) form a complex in the endoplasmic reticulum which is responsible for 3-hydroxylation of a limited number of proline residues in types I, II and V collagens.	Proline	201-208	cartilage associated protein	Homo sapiens	31-59
17630507-1	2007	Prolyl 3-hydroxylase 1 (P3H1), cartilage-associated protein (CRTAP) and cyclophilin B (CyPB) form a complex in the endoplasmic reticulum which is responsible for 3-hydroxylation of a limited number of proline residues in types I, II and V collagens.	Proline	201-208	cartilage associated protein	Homo sapiens	61-66
17630507-1	2007	Prolyl 3-hydroxylase 1 (P3H1), cartilage-associated protein (CRTAP) and cyclophilin B (CyPB) form a complex in the endoplasmic reticulum which is responsible for 3-hydroxylation of a limited number of proline residues in types I, II and V collagens.	Proline	201-208	peptidylprolyl isomerase B	Homo sapiens	72-85
17630507-1	2007	Prolyl 3-hydroxylase 1 (P3H1), cartilage-associated protein (CRTAP) and cyclophilin B (CyPB) form a complex in the endoplasmic reticulum which is responsible for 3-hydroxylation of a limited number of proline residues in types I, II and V collagens.	Proline	201-208	peptidylprolyl isomerase B	Homo sapiens	87-91
17617578-2	2007	We have screened a human Src homology 3 (SH3) domain phage display library for proteins that can bind to the proline-rich region of CD3epsilon.	Proline	109-116	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	132-142
17606903-5	2007	The PAR4 fragment, traced entirely in the electron density maps except for five C-terminal residues, clamps Trp-60d, Tyr-60a, and the aryl-binding site of thrombin with Pro-56 and Pro-58 at the P2 and P4 positions and engages the primary specificity pocket with Arg-59.	Proline	169-172	coagulation factor II (thrombin) receptor-like 3	Mus musculus	4-8
17606903-5	2007	The PAR4 fragment, traced entirely in the electron density maps except for five C-terminal residues, clamps Trp-60d, Tyr-60a, and the aryl-binding site of thrombin with Pro-56 and Pro-58 at the P2 and P4 positions and engages the primary specificity pocket with Arg-59.	Proline	169-172	coagulation factor II	Mus musculus	155-163
17606903-5	2007	The PAR4 fragment, traced entirely in the electron density maps except for five C-terminal residues, clamps Trp-60d, Tyr-60a, and the aryl-binding site of thrombin with Pro-56 and Pro-58 at the P2 and P4 positions and engages the primary specificity pocket with Arg-59.	Proline	180-183	coagulation factor II	Mus musculus	155-163
17486143-0	2007	Agonist-dependent consequences of proline to alanine substitution in the transmembrane helices of the calcitonin receptor.	Proline	34-41	calcitonin receptor	Homo sapiens	102-121
17584692-1	2007	OBJECTIVE: mXin alpha, a downstream target gene of Nkx2.5 transcription factor, was shown to encode a proline-rich and Xin repeats-containing protein which localizes to the intercalated disc of adult hearts.	Proline	102-109	xin actin-binding repeat containing 1	Mus musculus	11-21
17584692-1	2007	OBJECTIVE: mXin alpha, a downstream target gene of Nkx2.5 transcription factor, was shown to encode a proline-rich and Xin repeats-containing protein which localizes to the intercalated disc of adult hearts.	Proline	102-109	NK2 homeobox 5	Mus musculus	51-57
17486143-4	2007	EXPERIMENTAL APPROACH: Proline residues within the transmembrane domains of the calcitonin receptor (P246, P249, P280, P326, P336) were individually mutated to alanine (A) using site-directed mutagenesis.	Proline	23-30	calcitonin receptor	Homo sapiens	80-99
17475650-4	2007	Sequence analysis showed that TRIM5alpha-sensitive viruses had proline at the 120th position of the capsid protein (CA), whereas TRIM5alpha-resistant viruses had either alanine or glutamine.	Proline	63-70	tripartite motif containing 5	Homo sapiens	30-40
17382517-9	2007	This interaction requires the characteristic proline cluster in the Rgl3 amino-terminal domain.	Proline	45-52	ral guanine nucleotide dissociation stimulator like 3	Homo sapiens	68-72
17591690-3	2007	Cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, is most active in the central nervous system and plays a variety of roles in neuronal degeneration.	Proline	36-43	cyclin dependent kinase 5	Homo sapiens	0-25
17591690-3	2007	Cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, is most active in the central nervous system and plays a variety of roles in neuronal degeneration.	Proline	36-43	cyclin dependent kinase 5	Homo sapiens	27-31
17377743-0	2007	Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma.	Proline	0-7	peptidase D	Homo sapiens	41-50
17377743-1	2007	PURPOSE: To determine the bioactivation and uptake of prolidase-targeted proline prodrugs of melphalan in six cancer cell lines with variable prolidase expression and to evaluate prolidase-dependence of prodrug cytotoxicity in the cell lines compared to that of the parent drug, melphalan.	Proline	73-80	peptidase D	Homo sapiens	54-63
17377743-1	2007	PURPOSE: To determine the bioactivation and uptake of prolidase-targeted proline prodrugs of melphalan in six cancer cell lines with variable prolidase expression and to evaluate prolidase-dependence of prodrug cytotoxicity in the cell lines compared to that of the parent drug, melphalan.	Proline	73-80	peptidase D	Homo sapiens	142-151
17377743-1	2007	PURPOSE: To determine the bioactivation and uptake of prolidase-targeted proline prodrugs of melphalan in six cancer cell lines with variable prolidase expression and to evaluate prolidase-dependence of prodrug cytotoxicity in the cell lines compared to that of the parent drug, melphalan.	Proline	73-80	peptidase D	Homo sapiens	142-151
17427961-6	2007	As compared with MT2, we found a characteristic conformation formed in the fragment (residue 1-13) at the N-terminus of MT3 owing to the constraint induced by 5TCPCP9, in which Pro7 and Pro9 residues are on the same side of the protein, both facing outward and the two 5-member rings of prolines are arranged almost in parallel, while Thr5 is on the opposite side.	Proline	287-295	metallothionein 3	Homo sapiens	120-123
17653038-9	2007	This mutation results in a substitution of proline for arginine in the helix termination motif that may disrupt the normal helix, leading to a dramatic structural change of the keratin 12 protein.	Proline	43-50	keratin 12	Homo sapiens	177-187
17439949-2	2007	Gln3 is cytoplasmic in cells provided with repressive nitrogen sources such as glutamine and is nuclear in cells growing with a derepressive nitrogen source such as proline or those treated with rapamycin or methionine sulfoximine (Msx).	Proline	165-172	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	0-4
17492690-2	2007	The TP53 polymorphism, in which an arginine (R) is changed to proline (P) at codon 72, is functionally significant and could therefore be a predisposing genetic defect.	Proline	62-69	tumor protein p53	Homo sapiens	4-8
17384076-1	2007	Molecular dynamics simulations followed by quantum mechanical calculation and Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBSA) analysis have been carried out to study binding of proline- and pyrazinone-based macrocyclic inhibitors (L86 and T76) to human alpha-thrombin.	Proline	190-197	coagulation factor II, thrombin	Homo sapiens	272-280
17519285-4	2007	Either or both of the highly conserved proline residues in the Cdk1 phosphorylation consensus sequence motifs were mutated to alanine (Cdc27 P304A or P456A).	Proline	39-46	Cyclin-dependent kinase 1	Drosophila melanogaster	63-67
17438336-6	2007	Analysis of FAK(-/-) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity, Tyr-397 phosphorylation, and the Pro-712/713 proline-rich region of FAK were required for TNFalpha-stimulated MAPK activation and IL-6 production.	Proline	167-170	protein tyrosine kinase 2	Homo sapiens	80-83
17438336-6	2007	Analysis of FAK(-/-) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity, Tyr-397 phosphorylation, and the Pro-712/713 proline-rich region of FAK were required for TNFalpha-stimulated MAPK activation and IL-6 production.	Proline	167-170	protein tyrosine kinase 2	Homo sapiens	80-83
17438336-6	2007	Analysis of FAK(-/-) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity, Tyr-397 phosphorylation, and the Pro-712/713 proline-rich region of FAK were required for TNFalpha-stimulated MAPK activation and IL-6 production.	Proline	167-170	protein tyrosine kinase 2	Homo sapiens	80-83
17438336-6	2007	Analysis of FAK(-/-) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity, Tyr-397 phosphorylation, and the Pro-712/713 proline-rich region of FAK were required for TNFalpha-stimulated MAPK activation and IL-6 production.	Proline	179-186	protein tyrosine kinase 2	Homo sapiens	80-83
17438336-6	2007	Analysis of FAK(-/-) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity, Tyr-397 phosphorylation, and the Pro-712/713 proline-rich region of FAK were required for TNFalpha-stimulated MAPK activation and IL-6 production.	Proline	179-186	protein tyrosine kinase 2	Homo sapiens	80-83
17438336-6	2007	Analysis of FAK(-/-) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity, Tyr-397 phosphorylation, and the Pro-712/713 proline-rich region of FAK were required for TNFalpha-stimulated MAPK activation and IL-6 production.	Proline	179-186	protein tyrosine kinase 2	Homo sapiens	80-83
17467737-2	2007	U5-52K binds to the CD2 receptor via its GYF-domain specifically recognizing a proline-rich motif on the cytoplasmic surface of the receptor.	Proline	79-86	CD2 cytoplasmic tail binding protein 2	Homo sapiens	0-6
17467737-2	2007	U5-52K binds to the CD2 receptor via its GYF-domain specifically recognizing a proline-rich motif on the cytoplasmic surface of the receptor.	Proline	79-86	CD2 molecule	Homo sapiens	20-23
17462669-4	2007	We identified an interaction of paxillin with the vinexin adaptor protein family member ponsin in nascent costameres during muscle differentiation, which is mediated by an interaction of the second src homology domain 3 (SH3) domain of ponsin with the proline-rich region of paxillin.	Proline	252-259	paxillin	Homo sapiens	32-40
17498690-5	2007	In neurons, the carboxyl-terminal tail domains of the NF-M and NF-H subunits of heteropolymeric neurofilaments (NFs) are highly phosphorylated by proline-directed protein kinases.	Proline	146-153	neurofilament medium chain	Homo sapiens	54-58
17498690-5	2007	In neurons, the carboxyl-terminal tail domains of the NF-M and NF-H subunits of heteropolymeric neurofilaments (NFs) are highly phosphorylated by proline-directed protein kinases.	Proline	146-153	neurofilament heavy chain	Homo sapiens	63-67
17237826-4	2007	Our studies indicate that localization of c-Cbl to the membrane is likely to be mediated by the tyrosine kinase binding (TKB) domain and the proline-rich region of c-Cbl, whereas C-terminal tyrosine phosphorylation does not play a role.	Proline	141-148	Cbl proto-oncogene	Homo sapiens	42-47
17503777-6	2007	Replacement of Pro75 with arginine, a residue that occurs in place of Pro in peroxiredoxins, also led to the formation of the cluster in the thioredoxin.	Proline	15-18	thioredoxin	Homo sapiens	141-152
17462669-4	2007	We identified an interaction of paxillin with the vinexin adaptor protein family member ponsin in nascent costameres during muscle differentiation, which is mediated by an interaction of the second src homology domain 3 (SH3) domain of ponsin with the proline-rich region of paxillin.	Proline	252-259	sorbin and SH3 domain containing 1	Homo sapiens	88-94
17476305-5	2007	We demonstrated that extracellular stimuli such as the addition of estrogen, induced phosphorylation of SIP in its PEST (Proline, Glutamate, Serine, and Threonine rich) domain by casein kinase II.	Proline	121-128	KN motif and ankyrin repeat domains 2	Homo sapiens	104-107
17462669-4	2007	We identified an interaction of paxillin with the vinexin adaptor protein family member ponsin in nascent costameres during muscle differentiation, which is mediated by an interaction of the second src homology domain 3 (SH3) domain of ponsin with the proline-rich region of paxillin.	Proline	252-259	sorbin and SH3 domain containing 1	Homo sapiens	236-242
17462669-4	2007	We identified an interaction of paxillin with the vinexin adaptor protein family member ponsin in nascent costameres during muscle differentiation, which is mediated by an interaction of the second src homology domain 3 (SH3) domain of ponsin with the proline-rich region of paxillin.	Proline	252-259	paxillin	Homo sapiens	275-283
17552908-1	2007	We studied the interaction of the artificial 12-aa proline-rich peptide PD1 with the SH3 domain of the hematopoietic cell kinase Hck and the peptide"s potency in competitively displacing HIV-1 Nef from the Hck SH3 domain.	Proline	51-58	programmed cell death 1	Mus musculus	72-75
17434460-4	2007	A sequence comparison revealed an extra proline in the TM2-TM3 loop of the 5-HT3A receptor (5-HT3AR) that is not found in the glycine receptor (GlyR).	Proline	40-47	tropomyosin 3	Homo sapiens	59-62
17434460-6	2007	A lysine to proline mutation was introduced into the TM2-TM3 linker region at position 281 (K281P) of the alpha1 GlyR.	Proline	12-19	tropomyosin 3	Homo sapiens	57-60
17434460-6	2007	A lysine to proline mutation was introduced into the TM2-TM3 linker region at position 281 (K281P) of the alpha1 GlyR.	Proline	12-19	glycine receptor alpha 1	Homo sapiens	106-117
16973168-4	2007	The high-arsenic exposure group with GSTP1 variant genotypes of Ile/Val and Val/Val, and with the p53 variant genotypes of Arg/Pro and Pro/Pro had 6.0- and 3.1-fold higher risks of carotid atherosclerosis, respectively.	Proline	127-130	tumor protein p53	Homo sapiens	98-101
16973168-4	2007	The high-arsenic exposure group with GSTP1 variant genotypes of Ile/Val and Val/Val, and with the p53 variant genotypes of Arg/Pro and Pro/Pro had 6.0- and 3.1-fold higher risks of carotid atherosclerosis, respectively.	Proline	135-138	tumor protein p53	Homo sapiens	98-101
16973168-4	2007	The high-arsenic exposure group with GSTP1 variant genotypes of Ile/Val and Val/Val, and with the p53 variant genotypes of Arg/Pro and Pro/Pro had 6.0- and 3.1-fold higher risks of carotid atherosclerosis, respectively.	Proline	135-138	tumor protein p53	Homo sapiens	98-101
17612631-0	2007	Probing the role of the conserved beta-II turn Pro-76/Gly-77 of mitochondrial cytochrome c.	Proline	0-3	cytochrome c, somatic	Homo sapiens	78-90
17449694-4	2007	This mutant was recently shown to carry an allele of PRO1 which encodes the Asp154Asn mutant gamma-glutamyl kinase (GK), the first enzyme of the proline biosynthetic pathway.	Proline	145-152	glutamate 5-kinase	Saccharomyces cerevisiae S288C	53-57
17300219-0	2007	A proline repeat domain in the Notch co-activator MAML1 is important for the p300-mediated acetylation of MAML1.	Proline	2-9	mastermind like transcriptional coactivator 1	Homo sapiens	50-55
17300219-0	2007	A proline repeat domain in the Notch co-activator MAML1 is important for the p300-mediated acetylation of MAML1.	Proline	2-9	E1A binding protein p300	Homo sapiens	77-81
17300219-0	2007	A proline repeat domain in the Notch co-activator MAML1 is important for the p300-mediated acetylation of MAML1.	Proline	2-9	mastermind like transcriptional coactivator 1	Homo sapiens	106-111
17300219-6	2007	The N-terminal domain of MAML1 contains a proline repeat motif (PXPAAPAP) that was previously shown to be present in p53 and important for the p300-p53 interaction.	Proline	42-49	mastermind like transcriptional coactivator 1	Homo sapiens	25-30
17300219-6	2007	The N-terminal domain of MAML1 contains a proline repeat motif (PXPAAPAP) that was previously shown to be present in p53 and important for the p300-p53 interaction.	Proline	42-49	tumor protein p53	Homo sapiens	117-120
17300219-7	2007	We show that the MAML1 proline repeat motif interacts with p300 and enhances the activity of the MAML1 N-terminus in vivo.	Proline	23-30	mastermind like transcriptional coactivator 1	Homo sapiens	17-22
17300219-7	2007	We show that the MAML1 proline repeat motif interacts with p300 and enhances the activity of the MAML1 N-terminus in vivo.	Proline	23-30	E1A binding protein p300	Homo sapiens	59-63
17300219-7	2007	We show that the MAML1 proline repeat motif interacts with p300 and enhances the activity of the MAML1 N-terminus in vivo.	Proline	23-30	mastermind like transcriptional coactivator 1	Homo sapiens	97-102
17552908-1	2007	We studied the interaction of the artificial 12-aa proline-rich peptide PD1 with the SH3 domain of the hematopoietic cell kinase Hck and the peptide"s potency in competitively displacing HIV-1 Nef from the Hck SH3 domain.	Proline	51-58	hemopoietic cell kinase	Mus musculus	129-132
17545633-0	2007	Oncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptor.	Proline	56-63	estrogen receptor 1	Homo sapiens	148-165
17438369-6	2007	RUNX2 associated with YAP65 via a proline-rich segment in the C-terminal domain (PPPY) and coexpression of RUNX2 and YAP65 significantly increased foci formation and anchorage-independent growth relative to each factor alone.	Proline	34-41	RUNX family transcription factor 2	Homo sapiens	0-5
17438369-6	2007	RUNX2 associated with YAP65 via a proline-rich segment in the C-terminal domain (PPPY) and coexpression of RUNX2 and YAP65 significantly increased foci formation and anchorage-independent growth relative to each factor alone.	Proline	34-41	Yes1 associated transcriptional regulator	Homo sapiens	22-27
17545633-1	2007	Proline-, glutamic acid-, leucine-rich protein 1 (PELP1), a novel nuclear receptor coactivator, and its expression is deregulated in hormone-dependent cancers, including those of the breast, endometrium, and ovary.	Proline	0-7	proline, glutamate and leucine rich protein 1	Homo sapiens	50-55
17671760-2	2007	The proapoptotic activity of p53 seems to be strictly related to proline-rich regions, homologous to the SH3 binding domain.	Proline	65-72	tumor protein p53	Homo sapiens	29-32
17878957-1	2007	Prolyl oligopeptidase (POP) is a ubiquitous post-proline cleaving enzyme that is highly expressed in brain.	Proline	49-56	prolyl endopeptidase	Homo sapiens	0-21
17878957-1	2007	Prolyl oligopeptidase (POP) is a ubiquitous post-proline cleaving enzyme that is highly expressed in brain.	Proline	49-56	prolyl endopeptidase	Homo sapiens	23-26
17504512-4	2007	The polymorphism on p53, which encodes either a proline or an arginine amino acid residue at codon 72, has been reported as a possible risk factor for cervical disease.	Proline	48-55	tumor protein p53	Homo sapiens	20-23
17551816-2	2007	O(2)-dependent hydroxylation of two proline residues in the HIF-1alpha subunit is necessary for the binding of the von Hippel-Lindau (VHL) protein, which is a component of a ubiquitin protein ligase that ubiquitinates HIF-1alpha, leading to its degradation by the proteasome.	Proline	36-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
17551816-2	2007	O(2)-dependent hydroxylation of two proline residues in the HIF-1alpha subunit is necessary for the binding of the von Hippel-Lindau (VHL) protein, which is a component of a ubiquitin protein ligase that ubiquitinates HIF-1alpha, leading to its degradation by the proteasome.	Proline	36-43	von Hippel-Lindau tumor suppressor	Homo sapiens	115-132
17551816-2	2007	O(2)-dependent hydroxylation of two proline residues in the HIF-1alpha subunit is necessary for the binding of the von Hippel-Lindau (VHL) protein, which is a component of a ubiquitin protein ligase that ubiquitinates HIF-1alpha, leading to its degradation by the proteasome.	Proline	36-43	von Hippel-Lindau tumor suppressor	Homo sapiens	134-137
17551816-2	2007	O(2)-dependent hydroxylation of two proline residues in the HIF-1alpha subunit is necessary for the binding of the von Hippel-Lindau (VHL) protein, which is a component of a ubiquitin protein ligase that ubiquitinates HIF-1alpha, leading to its degradation by the proteasome.	Proline	36-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	218-228
17596655-9	2007	Among two novel CAPN3 mutations, one was a missense mutation (c.2125T&gt;C [p.709Ser&gt;Pro]), and the other was a small in-frame deletion causing omission of a single amino acid (c.2355-2357delTTC [p.786delPhe]).	Proline	88-91	calpain 3	Homo sapiens	16-21
16777263-9	2007	Delta(1)-Pyrroline-5-carboxylate synthetase (P5CS) activity did not show a specific response, indicating that P5CR might be the limiting step in proline synthesis from glutamate at high salinity.	Proline	145-152	pyrroline-5-carboxylate reductase	Triticum aestivum	110-114
17657522-10	2007	The interaction between Nedd4 and Cx43 is mediated by the WW domains of Nedd4 and involves a proline-rich sequence conforming to a PY (XPPXY) consensus motif in the C terminus of Cx43.	Proline	93-100	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	24-29
17657522-10	2007	The interaction between Nedd4 and Cx43 is mediated by the WW domains of Nedd4 and involves a proline-rich sequence conforming to a PY (XPPXY) consensus motif in the C terminus of Cx43.	Proline	93-100	gap junction protein alpha 1	Homo sapiens	34-38
17372332-6	2007	The results indicated that substitution with a negatively charged residue or a proline impaired cell surface expression of SR-BI or its interaction with HDL, respectively.	Proline	79-86	scavenger receptor class B member 1	Homo sapiens	123-128
17392367-10	2007	We concluded that the proline content, but not the leucine content, of the LR is critical for determining the oligomeric state of Rta.	Proline	22-29	MAS related GPR family member F	Homo sapiens	130-133
17428861-7	2007	The ability of ALIX to rescue a PTAP mutant also depends on its C-terminal proline-rich domain (PRD), but not on the binding sites for Tsg101, endophilin, CIN85, or for the newly identified binding partner, CMS, within the PRD.	Proline	75-82	programmed cell death 6 interacting protein	Homo sapiens	15-19
17376929-7	2007	Our data suggest that a proline-rich sequence motif in the variable region of M50/UL50 represents a new functional site which is essential for nuclear egress of cytomegalovirus capsids.	Proline	24-31	nuclear egress membrane protein	Human betaherpesvirus 5	82-86
17403527-1	2007	A very common polymorphism of p53, that of codon 72, codes either for a proline (P72) or an arginine (R72).	Proline	72-79	tumor protein p53	Homo sapiens	30-33
17392367-6	2007	The proline-rich, N-terminal leucine heptapeptide repeat (LR) of ORF50 (amino acids [aa] 244 to 275) is necessary but not sufficient for oligomer formation and functions in concert with the central portion of ORF50/Rta (aa 245 to 414).	Proline	4-11	MAS related GPR family member F	Homo sapiens	215-218
17325034-8	2007	Deletion of a proline-rich domain within RARgamma abrogated this interaction in vivo.	Proline	14-21	retinoic acid receptor gamma	Homo sapiens	41-49
17403527-1	2007	A very common polymorphism of p53, that of codon 72, codes either for a proline (P72) or an arginine (R72).	Proline	72-79	DEAD-box helicase 17	Homo sapiens	81-84
17160015-2	2007	DNA damage leads to phosphorylation on the Ser/Thr-Pro motifs of p53, which facilitates interaction with Pin1, a pSer/pThr-Pro-specific peptidyl prolyl isomerase.	Proline	51-54	transformation related protein 53, pseudogene	Mus musculus	65-68
17160015-2	2007	DNA damage leads to phosphorylation on the Ser/Thr-Pro motifs of p53, which facilitates interaction with Pin1, a pSer/pThr-Pro-specific peptidyl prolyl isomerase.	Proline	51-54	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	105-109
17403676-8	2007	This interaction is dependent on the proline-rich domain (PRD) of Rin1 as Rin1DeltaPRD, a mutant lacking the PRD, does not interact with STAM2.	Proline	37-44	Ras and Rab interactor 1	Homo sapiens	66-70
17474767-1	2007	In this work we investigate the interactions that occur between the aromatic portion of the set of fluorinated N-(4-sulfamylbenzoyl)benzylamine (SBB) inhibitors and two residues of Human Carbonic Anhydrase II (HCAII), namely Phe-131 and Pro-202.	Proline	237-240	carbonic anhydrase 2	Homo sapiens	187-208
17371873-9	2007	Consistent with the preference of hCdc14A for phosphorylations mediated by proline-directed kinases, we find that RN-tre is a direct substrate of cyclin-dependent kinase.	Proline	75-82	cell division cycle 14A	Homo sapiens	34-41
17418095-0	2007	Actin binding and proline rich motifs of CR16 play redundant role in growth of vrp1Delta cells.	Proline	18-25	WAS/WASL interacting protein family member 3	Homo sapiens	41-45
17418095-4	2007	Mutations in the actin binding motif alone did not abolish the activity of CR16 but the mutations in combination with deletion of N-terminal proline rich motif abolished the ability of CR16 to suppress the growth defect.	Proline	141-148	WAS/WASL interacting protein family member 3	Homo sapiens	185-189
17397867-1	2007	The catalytic activity of human FKBP12 as a prolyl isomerase is high towards short peptides, but very low in proline-limited protein folding reactions.	Proline	109-116	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	32-38
17525794-1	2007	Proline-, glutamic acid-, and leucine-rich protein (PELP)1, also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a novel nuclear receptor coregulator with a multitude of functions.	Proline	0-7	proline, glutamate and leucine rich protein 1	Homo sapiens	52-58
17525794-1	2007	Proline-, glutamic acid-, and leucine-rich protein (PELP)1, also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a novel nuclear receptor coregulator with a multitude of functions.	Proline	0-7	proline, glutamate and leucine rich protein 1	Homo sapiens	132-136
17344208-1	2007	Proline dehydrogenase (PRODH) and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH) catalyze the two-step oxidation of proline to glutamate.	Proline	124-131	proline dehydrogenase 1	Homo sapiens	23-28
17428436-10	2007	These data demonstrate that position 3 amino acid substitution of GIP with (Ala(3)), (Phe(3)), (Tyr(3)) or (Pro(3)) provides a new class of functional GIP receptor antagonists.	Proline	108-111	gastric inhibitory polypeptide	Rattus norvegicus	66-69
17428436-10	2007	These data demonstrate that position 3 amino acid substitution of GIP with (Ala(3)), (Phe(3)), (Tyr(3)) or (Pro(3)) provides a new class of functional GIP receptor antagonists.	Proline	108-111	gastric inhibitory polypeptide	Rattus norvegicus	151-154
17357163-2	2007	Nine alpha-MSH peptide analogues were constructed by exchanging the Trp9 residue in the alpha-MSH core with the natural or artificial amino acids Arg, Asp, Cys, Gly, Leu, Nal, d-Nal, Pro, or d-Trp.	Proline	183-186	proopiomelanocortin	Homo sapiens	5-14
17355961-0	2007	Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains.	Proline	74-81	three prime repair exonuclease 1	Homo sapiens	37-42
17355961-8	2007	Furthermore, we detected the presence of a conserved proline-rich region on the surface of TREX1.	Proline	53-60	three prime repair exonuclease 1	Homo sapiens	91-96
17350957-3	2007	The Ubc9-interacting domain of HMGA1 is bipartite, consisting of a proline-rich region near the N terminus and an acidic domain at the extreme C terminus, whereas the HMGA1-interacting domain of Ubc9 comprises a single region previously shown to associate with and SUMOylate other transcription factors.	Proline	67-74	ubiquitin conjugating enzyme E2 I	Homo sapiens	4-8
17391696-1	2007	iASPP is an inhibitory member of ASPP (apoptosis stimulating protein of p53, or Ankyrin repeats, SH3 domain and proline-rich region contain Protein) family.	Proline	112-119	protein phosphatase 1 regulatory subunit 13 like	Homo sapiens	0-5
17439122-0	2007	Practical synthesis of enantiomerically pure beta2-amino acids via proline-catalyzed diastereoselective aminomethylation of aldehydes.	Proline	67-74	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	45-50
17439157-2	2007	Central to this pathway is PglB, a homologue of the Stt3p subunit of the eukaryotic oligosaccharyl transferase (OT), which is involved in the transfer of an oligosaccharide from a polyisoprenyl pyrophosphate carrier to the asparagine side chain of proteins within the conserved glycosylation sites D/E-X1-N-X2-S/T, where X1 and X2 can be any amino acids except proline.	Proline	361-368	epiphycan	Homo sapiens	27-31
17368484-0	2007	The conserved active site proline determines the reducing power of Staphylococcus aureus thioredoxin.	Proline	26-33	AT695_RS07555	Staphylococcus aureus	89-100
17130838-1	2007	Human p53, unlike mouse p53, contains a polymorphic site at codon 72 in exon 4 encoding either an arginine amino acid (72R) or a proline residue (72P).	Proline	129-136	transformation related protein 53, pseudogene	Mus musculus	6-9
17350957-3	2007	The Ubc9-interacting domain of HMGA1 is bipartite, consisting of a proline-rich region near the N terminus and an acidic domain at the extreme C terminus, whereas the HMGA1-interacting domain of Ubc9 comprises a single region previously shown to associate with and SUMOylate other transcription factors.	Proline	67-74	high mobility group AT-hook 1	Homo sapiens	31-36
17368484-3	2007	The intriguing role of the highly conserved proline in the ubiquitous reducing agent thioredoxin was studied by site-specific mutagenesis of Staphylococcus aureus thioredoxin (Sa_Trx).	Proline	44-51	AT695_RS07555	Staphylococcus aureus	85-96
17368484-3	2007	The intriguing role of the highly conserved proline in the ubiquitous reducing agent thioredoxin was studied by site-specific mutagenesis of Staphylococcus aureus thioredoxin (Sa_Trx).	Proline	44-51	AT695_RS07555	Staphylococcus aureus	163-174
17317162-1	2007	In the search for an inhibitor of dipeptidyl peptidase IV (DPP-IV) highly potent both in vitro and in vivo, we synthesized a series of L-prolylthiazolidine-based DPP-IV inhibitors having 4-arylpiperazine or 4-arylpiperidine at the gamma-position of the proline structure.	Proline	253-260	dipeptidyl peptidase 4	Homo sapiens	34-57
17368484-13	2007	In conclusion, the active site proline in thioredoxin determines the driving potential for substrate reduction.	Proline	31-38	AT695_RS07555	Staphylococcus aureus	42-53
17317162-1	2007	In the search for an inhibitor of dipeptidyl peptidase IV (DPP-IV) highly potent both in vitro and in vivo, we synthesized a series of L-prolylthiazolidine-based DPP-IV inhibitors having 4-arylpiperazine or 4-arylpiperidine at the gamma-position of the proline structure.	Proline	253-260	dipeptidyl peptidase 4	Homo sapiens	59-65
17373643-0	2007	Mapping of the epitope of monoclonal antibody 2B4 to the proline-rich region of human Huntingtin, a region critical for aggregation and toxicity.	Proline	57-64	huntingtin	Homo sapiens	86-96
17631738-7	2007	All of the RA patients and controls were genotyped by the polymerase chain reaction and allele-specific oligonucleotide techniques for p53 gene polymorphism Arg/Pro at codon 72.	Proline	161-164	tumor protein p53	Homo sapiens	135-138
17373643-8	2007	Furthermore, the 2B4 epitope resides within the proline-rich region of Huntingtin, which is critical for polyQ aggregation and toxicity.	Proline	48-55	CD244 molecule A	Mus musculus	17-20
17373643-8	2007	Furthermore, the 2B4 epitope resides within the proline-rich region of Huntingtin, which is critical for polyQ aggregation and toxicity.	Proline	48-55	huntingtin	Mus musculus	71-81
17395357-4	2007	Compared to E. coli RPL12, the four mature RPL12 variants show a conserved C-terminal region that contains all the functional domains of prokaryotic RPL12 but three of them present an additional N-terminal extension containing either an acidic or a basic domain and a high level of proline residues.	Proline	282-289	ribosomal protein L12	Homo sapiens	43-48
17395357-4	2007	Compared to E. coli RPL12, the four mature RPL12 variants show a conserved C-terminal region that contains all the functional domains of prokaryotic RPL12 but three of them present an additional N-terminal extension containing either an acidic or a basic domain and a high level of proline residues.	Proline	282-289	ribosomal protein L12	Homo sapiens	43-48
17631738-2	2007	The wild type p53 protein presents a common polymorphism at position 72 resulting in either a proline or an arginine residue at this position, leading to differences between the two variants in the induction of apoptosis.	Proline	94-101	tumor protein p53	Homo sapiens	14-17
17393485-3	2007	We show that the whitesnake mutant corresponds to the sfpq (splicing factor, proline/glutamine rich) gene, encoding the PSF protein (polypyrimidine tract-binding protein-associated splicing factor).	Proline	77-84	splicing factor proline/glutamine-rich	Danio rerio	54-58
17418139-1	2007	SH3 domains from the Src family of tyrosine kinases represent an interesting example of the delicate balance between promiscuity and specificity characteristic of proline-rich ligand recognition by SH3 domains.	Proline	163-170	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	21-24
17382318-7	2007	We conclude that TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin via the SH3 domain of TULA binding proline-rich sequences in dynamin.	Proline	171-178	ubiquitin associated and SH3 domain containing A	Homo sapiens	17-21
17382318-7	2007	We conclude that TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin via the SH3 domain of TULA binding proline-rich sequences in dynamin.	Proline	171-178	ubiquitin associated and SH3 domain containing A	Homo sapiens	158-162
17235325-6	2007	The KAP24.1 protein consisted of 254 amino acids, exhibited a high content of serine, proline, and tyrosine, but low cysteine content and possessed several carboxyterminal tyrosine-containing tandem decameric repeat structures.	Proline	86-93	keratin associated protein 24-1	Homo sapiens	4-11
17273174-5	2007	We identify Proline 13 within the N-terminus of Bax as critical for this regulation.	Proline	12-19	BCL2 associated X, apoptosis regulator	Homo sapiens	48-51
17273174-6	2007	The subcellular distribution of Proline 13 mutant Bax was identical to wild-type Bax in both healthy and apoptotic cells.	Proline	32-39	BCL2 associated X, apoptosis regulator	Homo sapiens	50-53
17273174-7	2007	However, Proline 13 mutant Bax induced rapid progression to commitment, mitochondrial permeabilisation and death.	Proline	9-16	BCL2 associated X, apoptosis regulator	Homo sapiens	27-30
17599946-1	2007	A TP53 gene polymorphism, resulting in an arginine (R) to proline (P) at codon 72 (TP53 R72P), has been associated with the susceptibility to various cancers.	Proline	58-65	tumor protein p53	Homo sapiens	2-6
17301132-7	2007	Coincidentally, a cluster of proline, arginine, and glycine precedes the Gag-Pol junction of MuLV.	Proline	29-36	Gag-Pol	Human immunodeficiency virus 1	73-80
17599946-1	2007	A TP53 gene polymorphism, resulting in an arginine (R) to proline (P) at codon 72 (TP53 R72P), has been associated with the susceptibility to various cancers.	Proline	58-65	tumor protein p53	Homo sapiens	83-87
17208332-1	2007	The TP53 gene has a polymorphism in exon 4 at codon 72 that presents the arginine or proline genotype.	Proline	85-92	tumor protein p53	Homo sapiens	4-8
17369432-0	2007	Calcium signaling via phospholipase C is essential for proline accumulation upon ionic but not nonionic hyperosmotic stresses in Arabidopsis.	Proline	55-62	phospholipase C1	Arabidopsis thaliana	22-37
17435751-3	2007	Here, we report that, unexpectedly, the amino-terminal serine or proline residue of RCC1 is uniquely methylated on its alpha-amino group.	Proline	65-72	regulator of chromosome condensation 1	Homo sapiens	84-88
17318317-4	2007	In addition to reduced ABA induction of RD29A, ggt1-1 was altered in ABA and stress regulation of Delta1-pyrroline-5-carboxylate synthase, proline dehydrogenase and 9-cis-epoxycarotenoid dioxygenase 3, which encode enzymes involved in Pro and ABA metabolism, respectively.	Proline	235-238	gamma-glutamyl transpeptidase 1	Arabidopsis thaliana	47-53
16650912-5	2007	Exogenous application of proline or betaine alleviated the reduction in catalase and peroxidase activities but not SOD activity under salt stress.	Proline	25-32	catalase isozyme 1	Nicotiana tabacum	72-80
16650912-5	2007	Exogenous application of proline or betaine alleviated the reduction in catalase and peroxidase activities but not SOD activity under salt stress.	Proline	25-32	peroxidase N1	Nicotiana tabacum	85-95
16650912-6	2007	In addition, proline was found to be effective in alleviating the inhibition of salt stress-induced catalase and peroxidase activities in BY-2 cells.	Proline	13-20	catalase isozyme 1	Nicotiana tabacum	100-108
17460754-6	2007	A frequent genetic variant of OCT2 with the amino acid substitution R400C reduced the transport efficiency for the cytoprotective cyclo(his-pro) and thereby increased the susceptibility to salsolinol-induced cell death.	Proline	119-122	POU class 2 homeobox 2	Homo sapiens	30-34
16650912-6	2007	In addition, proline was found to be effective in alleviating the inhibition of salt stress-induced catalase and peroxidase activities in BY-2 cells.	Proline	13-20	peroxidase N1	Nicotiana tabacum	113-123
17343823-4	2007	Among the genes identified, Orai1 contains a distinctive proline- and arginine-rich N-terminal cytoplasmic sequence.	Proline	57-64	ORAI calcium release-activated calcium modulator 1	Mus musculus	28-33
17460754-7	2007	CONCLUSIONS/SIGNIFICANCE: Our findings indicate that the OCT2-regulated interplay between cyclo(his-pro) and salsolinol is crucial for nigral cell integrity and that a shift in transport efficiency may impact the risk of Parkinson"s disease.	Proline	100-103	POU class 2 homeobox 2	Homo sapiens	57-61
17374643-6	2007	Using several mutant HRSL3 constructs, we identified the N-terminal proline-rich region within the HRSL3 protein as the domain that is relevant for both binding of PR65alpha and induction of programmed cell death.	Proline	68-75	phospholipase A and acyltransferase 3	Homo sapiens	21-26
17438079-4	2007	Transferring this region from CEA into NCAM in conjunction with the upstream proline (PGLSAG) was sufficient to specify the addition of the CEA anchor.	Proline	77-84	CEA cell adhesion molecule 5	Homo sapiens	30-33
17438079-4	2007	Transferring this region from CEA into NCAM in conjunction with the upstream proline (PGLSAG) was sufficient to specify the addition of the CEA anchor.	Proline	77-84	CEA cell adhesion molecule 5	Homo sapiens	140-143
17324938-2	2007	The transcriptional regulation of proline-rich membrane anchor (PRiMA), an anchoring protein of tetrameric globular form acetylcholinesterase (G(4) AChE), was revealed in muscle during myogenic differentiation under the influence of innervation.	Proline	34-41	proline rich membrane anchor 1	Mus musculus	64-69
17324938-2	2007	The transcriptional regulation of proline-rich membrane anchor (PRiMA), an anchoring protein of tetrameric globular form acetylcholinesterase (G(4) AChE), was revealed in muscle during myogenic differentiation under the influence of innervation.	Proline	34-41	acetylcholinesterase	Mus musculus	148-152
17412832-5	2007	Here, by resequencing and genotyping in patients with SLE, we find evidence for three functional alleles of IRF5: the previously described exon 1B splice site variant, a 30-bp in-frame insertion/deletion variant of exon 6 that alters a proline-, glutamic acid-, serine- and threonine-rich domain region, and a variant in a conserved polyA+ signal sequence that alters the length of the 3" UTR and stability of IRF5 mRNAs.	Proline	236-243	interferon regulatory factor 5	Homo sapiens	108-112
17406354-0	2007	The p53 codon 72 proline allele is endowed with enhanced cell-death inducing potential in cancer cells exposed to hypoxia.	Proline	17-24	tumor protein p53	Homo sapiens	4-7
17406354-1	2007	The preferential retention of the arginine allele at the p53 codon 72 locus is commonly observed in tumours from arginine/proline heterozygotes.	Proline	122-129	tumor protein p53	Homo sapiens	57-60
17406354-2	2007	Considering that cancer cells are harboured in a hypoxic environment in vivo, we here tested the hypothesis that the p53 codon 72 proline allele confers a survival disadvantage in presence of hypoxia.	Proline	130-137	tumor protein p53	Homo sapiens	117-120
17406354-3	2007	Here, we show that the transient transfection of the proline allele in p53 null cancer cells exposed to low oxygen tension or to the hypoxia-mimetic drug Desferoxamine induces a higher amount of cell death than the arginine allele.	Proline	53-60	tumor protein p53	Homo sapiens	71-74
17406354-4	2007	Accordingly, proline allele transiently transfected cell lines express lower levels of hypoxia pro-survival genes (HIF-1alpha, carbonic anhydrase IX, vascular endothelial growth factor, heme oxygenase-I, hepatocyte growth factor receptor, vascular endothelial growth factor receptor 2), compared to those transiently transfected with the arginine allele.	Proline	13-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
17406354-4	2007	Accordingly, proline allele transiently transfected cell lines express lower levels of hypoxia pro-survival genes (HIF-1alpha, carbonic anhydrase IX, vascular endothelial growth factor, heme oxygenase-I, hepatocyte growth factor receptor, vascular endothelial growth factor receptor 2), compared to those transiently transfected with the arginine allele.	Proline	13-20	carbonic anhydrase 9	Homo sapiens	127-148
17406354-4	2007	Accordingly, proline allele transiently transfected cell lines express lower levels of hypoxia pro-survival genes (HIF-1alpha, carbonic anhydrase IX, vascular endothelial growth factor, heme oxygenase-I, hepatocyte growth factor receptor, vascular endothelial growth factor receptor 2), compared to those transiently transfected with the arginine allele.	Proline	13-20	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	204-237
17406354-4	2007	Accordingly, proline allele transiently transfected cell lines express lower levels of hypoxia pro-survival genes (HIF-1alpha, carbonic anhydrase IX, vascular endothelial growth factor, heme oxygenase-I, hepatocyte growth factor receptor, vascular endothelial growth factor receptor 2), compared to those transiently transfected with the arginine allele.	Proline	13-20	kinase insert domain receptor	Homo sapiens	239-284
17406354-6	2007	These data indicate that the p53 codon 72 proline allele is less permissive for the growth of cancer cells in a hypoxic environment, and suggest that the preferential retention of the arginine allele in the tumour tissues of arginine/proline heterozygous patients may depend upon its lowered capacity to induce cell death in a hypoxic tumour environment.	Proline	42-49	tumor protein p53	Homo sapiens	29-32
17406354-6	2007	These data indicate that the p53 codon 72 proline allele is less permissive for the growth of cancer cells in a hypoxic environment, and suggest that the preferential retention of the arginine allele in the tumour tissues of arginine/proline heterozygous patients may depend upon its lowered capacity to induce cell death in a hypoxic tumour environment.	Proline	234-241	tumor protein p53	Homo sapiens	29-32
17374643-6	2007	Using several mutant HRSL3 constructs, we identified the N-terminal proline-rich region within the HRSL3 protein as the domain that is relevant for both binding of PR65alpha and induction of programmed cell death.	Proline	68-75	phospholipase A and acyltransferase 3	Homo sapiens	99-104
17374643-6	2007	Using several mutant HRSL3 constructs, we identified the N-terminal proline-rich region within the HRSL3 protein as the domain that is relevant for both binding of PR65alpha and induction of programmed cell death.	Proline	68-75	protein phosphatase 2 scaffold subunit Aalpha	Homo sapiens	164-173
17283073-7	2007	The N- and C-terminal domains of SpvB are linked by 7 proline residues.	Proline	54-61	virulence protein	Salmonella enterica	33-37
17239455-0	2007	Participation of transmembrane proline 82 in angiotensin II AT1 receptor signal transduction.	Proline	31-38	angiotensinogen	Homo sapiens	45-59
17382937-0	2007	A proline to glycine mutation in the Lck SH3-domain affects conformational sampling and increases ligand binding affinity.	Proline	2-9	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	37-40
17382937-2	2007	To test this hypothesis, we designed a mutant in which a proline in the RT-loop of the human Lck SH3-domain is replaced by glycine.	Proline	57-64	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	93-96
17239455-0	2007	Participation of transmembrane proline 82 in angiotensin II AT1 receptor signal transduction.	Proline	31-38	angiotensin II receptor type 1	Homo sapiens	60-63
17347650-2	2007	Here, we show that endogenous gephyrin undergoes proline-directed phosphorylation, which is followed by the recruitment of the peptidyl-prolyl isomerase Pin1.	Proline	49-56	gephyrin	Mus musculus	30-38
17347650-3	2007	The interaction between gephyrin and Pin1 is strictly dependent on gephyrin phosphorylation and requires serine-proline consensus sites encompassing the gephyrin proline-rich domain.	Proline	112-119	gephyrin	Mus musculus	24-32
17347650-2	2007	Here, we show that endogenous gephyrin undergoes proline-directed phosphorylation, which is followed by the recruitment of the peptidyl-prolyl isomerase Pin1.	Proline	49-56	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	153-157
17239455-4	2007	In this project we aimed to investigate the participation of two highly conserved proline residues (Pro82 and Pro162), located in TM II and TM IV, respectively, in AT1 receptor signal transduction.	Proline	82-89	angiotensin II receptor type 1	Homo sapiens	164-167
17347650-3	2007	The interaction between gephyrin and Pin1 is strictly dependent on gephyrin phosphorylation and requires serine-proline consensus sites encompassing the gephyrin proline-rich domain.	Proline	112-119	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	37-41
17347650-3	2007	The interaction between gephyrin and Pin1 is strictly dependent on gephyrin phosphorylation and requires serine-proline consensus sites encompassing the gephyrin proline-rich domain.	Proline	162-169	gephyrin	Mus musculus	24-32
17388495-6	2007	On going from Pro to Aze to Pip, the axiality (i.e., a tendency to adopt the axial orientation) of the NHMe group becomes stronger, which can be ascribed to reduce the steric hindrances between 1,2-substituted Ac and NHMe groups.	Proline	14-17	prolactin induced protein	Homo sapiens	28-31
17347650-3	2007	The interaction between gephyrin and Pin1 is strictly dependent on gephyrin phosphorylation and requires serine-proline consensus sites encompassing the gephyrin proline-rich domain.	Proline	162-169	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	37-41
17376963-4	2007	Srv2/CAP also harbors two proline-rich motifs and has been suggested to interact with profilin.	Proline	26-33	profilin	Saccharomyces cerevisiae S288C	86-94
17294180-5	2007	By generating recombinant HLA-B molecules and studying the eluted peptides by mass spectrometry and pool sequencing, we detected two different POmega peptide motifs within the B*41 group: Leu vs Val/Pro.	Proline	199-202	major histocompatibility complex, class I, B	Homo sapiens	26-31
17398099-2	2007	Dia-interacting protein (DIP) binds via its amino-terminal SH3 domain to the proline-rich formin homology 1 (FH1) domain of mDia1 and mDia2 and to the N-WASp proline-rich region.	Proline	77-84	NCK interacting protein with SH3 domain	Homo sapiens	0-23
17398099-2	2007	Dia-interacting protein (DIP) binds via its amino-terminal SH3 domain to the proline-rich formin homology 1 (FH1) domain of mDia1 and mDia2 and to the N-WASp proline-rich region.	Proline	77-84	NCK interacting protein with SH3 domain	Homo sapiens	25-28
17398099-2	2007	Dia-interacting protein (DIP) binds via its amino-terminal SH3 domain to the proline-rich formin homology 1 (FH1) domain of mDia1 and mDia2 and to the N-WASp proline-rich region.	Proline	77-84	diaphanous related formin 1	Mus musculus	124-129
17398099-2	2007	Dia-interacting protein (DIP) binds via its amino-terminal SH3 domain to the proline-rich formin homology 1 (FH1) domain of mDia1 and mDia2 and to the N-WASp proline-rich region.	Proline	77-84	diaphanous related formin 3	Mus musculus	134-139
17398099-2	2007	Dia-interacting protein (DIP) binds via its amino-terminal SH3 domain to the proline-rich formin homology 1 (FH1) domain of mDia1 and mDia2 and to the N-WASp proline-rich region.	Proline	158-165	NCK interacting protein with SH3 domain	Homo sapiens	0-23
17398099-2	2007	Dia-interacting protein (DIP) binds via its amino-terminal SH3 domain to the proline-rich formin homology 1 (FH1) domain of mDia1 and mDia2 and to the N-WASp proline-rich region.	Proline	158-165	NCK interacting protein with SH3 domain	Homo sapiens	25-28
17398099-2	2007	Dia-interacting protein (DIP) binds via its amino-terminal SH3 domain to the proline-rich formin homology 1 (FH1) domain of mDia1 and mDia2 and to the N-WASp proline-rich region.	Proline	158-165	WASP like actin nucleation promoting factor	Homo sapiens	151-157
17483057-2	2007	We detected a nonsense mutation, C7249T (resulting in Q2417X, where X is a termination codon) in the PEST domain of NOTCH1 in an ATL patient and detected a 3-bp deletion (positions 7234-7236) that resulted in deletion of a proline codon at codon 2412 in the PEST domain of NOTCH1 in a patient with a T-NHL, peripheral T-cell lymphoma-unspecified (PTCL-u).	Proline	223-230	notch receptor 1	Homo sapiens	116-122
17213274-9	2007	CONCLUSIONS: The proline allele at PPARG P12A increases risk for diabetes in persons with impaired glucose tolerance, an effect modified by body mass index.	Proline	17-24	peroxisome proliferator activated receptor gamma	Homo sapiens	35-40
17380208-7	2007	The stimulation of endocytosis of ROMK1 by WNK1 and WNK4 required specific proline-rich motifs of WNKs, but did not require their kinase activity.	Proline	75-82	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	34-39
17380208-7	2007	The stimulation of endocytosis of ROMK1 by WNK1 and WNK4 required specific proline-rich motifs of WNKs, but did not require their kinase activity.	Proline	75-82	WNK lysine deficient protein kinase 1	Homo sapiens	43-47
17380208-7	2007	The stimulation of endocytosis of ROMK1 by WNK1 and WNK4 required specific proline-rich motifs of WNKs, but did not require their kinase activity.	Proline	75-82	WNK lysine deficient protein kinase 4	Homo sapiens	52-56
17376963-6	2007	Here, we show that Saccharomyces cerevisiae Srv2 and profilin interact directly (K(D) approximately 1.3 microM) and demonstrate that a specific proline-rich motif in Srv2 mediates this interaction in vitro and in vivo.	Proline	144-151	profilin	Saccharomyces cerevisiae S288C	53-61
17251298-7	2007	Interestingly, the neutralization phenotypes were switched, so that amino acid residue 175 (Pro or Leu) located in the center of V2 was exchanged, indicating that the amino acid at position 175 has a crucial role, dramatically changing the Env oligomeric state on the membrane surface and affecting the neutralization phenotype against not only anti-V3 antibody but also recombinant soluble CD4.	Proline	92-95	endogenous retrovirus group K member 20	Homo sapiens	240-243
17189520-4	2007	Interaction with VHL requires hydroxylation of HIF-1alpha proline residues by prolyl hydroxylases (PHDs).	Proline	58-65	von Hippel-Lindau tumor suppressor	Homo sapiens	17-20
17189520-4	2007	Interaction with VHL requires hydroxylation of HIF-1alpha proline residues by prolyl hydroxylases (PHDs).	Proline	58-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57
17251298-7	2007	Interestingly, the neutralization phenotypes were switched, so that amino acid residue 175 (Pro or Leu) located in the center of V2 was exchanged, indicating that the amino acid at position 175 has a crucial role, dramatically changing the Env oligomeric state on the membrane surface and affecting the neutralization phenotype against not only anti-V3 antibody but also recombinant soluble CD4.	Proline	92-95	CD4 molecule	Homo sapiens	391-394
17322171-1	2007	Lipoma preferred partner (LPP) is a proline rich LIM domain family protein highly expressed at plasma membrane dense bodies and focal adhesions in smooth muscle cells.	Proline	36-43	LIM domain containing preferred translocation partner in lipoma	Homo sapiens	0-24
17384231-2	2007	While the cathepsin L-like cathepsin K (Tyr67Leu/Leu205Ala) mutant has a marked preference for Phe, the Leu67Tyr/Ala205Leu cathepsin L variant shows an effective cathepsin K-like preference for Leu and Pro.	Proline	202-205	cathepsin L	Homo sapiens	10-21
17384231-2	2007	While the cathepsin L-like cathepsin K (Tyr67Leu/Leu205Ala) mutant has a marked preference for Phe, the Leu67Tyr/Ala205Leu cathepsin L variant shows an effective cathepsin K-like preference for Leu and Pro.	Proline	202-205	cathepsin K	Homo sapiens	27-38
17384231-2	2007	While the cathepsin L-like cathepsin K (Tyr67Leu/Leu205Ala) mutant has a marked preference for Phe, the Leu67Tyr/Ala205Leu cathepsin L variant shows an effective cathepsin K-like preference for Leu and Pro.	Proline	202-205	cathepsin L	Homo sapiens	123-134
17283076-6	2007	Pulldown analysis with glutathione S-transferase-fused proline-rich regions of PTP-PEST revealed coprecipitation of WASP, PYK2, c-Src, and PSTPIP proteins with the N-terminal region (amino acids 294-497) of PTP-PEST.	Proline	55-62	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	79-87
17283076-6	2007	Pulldown analysis with glutathione S-transferase-fused proline-rich regions of PTP-PEST revealed coprecipitation of WASP, PYK2, c-Src, and PSTPIP proteins with the N-terminal region (amino acids 294-497) of PTP-PEST.	Proline	55-62	WASP actin nucleation promoting factor	Homo sapiens	116-120
17283076-6	2007	Pulldown analysis with glutathione S-transferase-fused proline-rich regions of PTP-PEST revealed coprecipitation of WASP, PYK2, c-Src, and PSTPIP proteins with the N-terminal region (amino acids 294-497) of PTP-PEST.	Proline	55-62	protein tyrosine kinase 2 beta	Homo sapiens	122-126
17283076-6	2007	Pulldown analysis with glutathione S-transferase-fused proline-rich regions of PTP-PEST revealed coprecipitation of WASP, PYK2, c-Src, and PSTPIP proteins with the N-terminal region (amino acids 294-497) of PTP-PEST.	Proline	55-62	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	128-133
17283076-6	2007	Pulldown analysis with glutathione S-transferase-fused proline-rich regions of PTP-PEST revealed coprecipitation of WASP, PYK2, c-Src, and PSTPIP proteins with the N-terminal region (amino acids 294-497) of PTP-PEST.	Proline	55-62	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	139-145
17283076-6	2007	Pulldown analysis with glutathione S-transferase-fused proline-rich regions of PTP-PEST revealed coprecipitation of WASP, PYK2, c-Src, and PSTPIP proteins with the N-terminal region (amino acids 294-497) of PTP-PEST.	Proline	55-62	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	207-215
17283076-7	2007	Similarly, interaction of the same signaling proteins, as well as PTP-PEST, was observed with glutathione S-transferase-fused proline-rich regions of WASP.	Proline	126-133	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	66-74
17283076-7	2007	Similarly, interaction of the same signaling proteins, as well as PTP-PEST, was observed with glutathione S-transferase-fused proline-rich regions of WASP.	Proline	126-133	WASP actin nucleation promoting factor	Homo sapiens	150-154
17322171-1	2007	Lipoma preferred partner (LPP) is a proline rich LIM domain family protein highly expressed at plasma membrane dense bodies and focal adhesions in smooth muscle cells.	Proline	36-43	LIM domain containing preferred translocation partner in lipoma	Homo sapiens	26-29
17084877-7	2007	Proline at position 308 in the V3 loop of gp120 was associated with brain compartmentalization in 3 patients, but mutagenesis studies suggested that P308 alone does not contribute to reduced CD4 dependence or macrophage-tropism.	Proline	0-7	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	42-47
17213202-2	2007	We found that the N-terminal (amino acids (aa) 1-68) and C-terminal (aa 416-674) kinase domains of RSK2 directly interacted with nuclear localization signal 1, the Ser/Pro repeat, and the polyproline domains (aa 261-365) of NFAT3.	Proline	168-171	ribosomal protein S6 kinase A3	Homo sapiens	99-103
17375202-9	2007	TAF8 forms a heterodimer with TAF10 through its HF and proline rich domains, and also interacts with SPT7L through its C-terminal region, and the three proteins form a complex in vitro and in vivo.	Proline	55-62	TATA-box binding protein associated factor 8	Homo sapiens	0-4
17220300-2	2007	Activation of S6K1 involves the phosphorylation of its multiple Ser/Thr residues, including the proline-directed sites (Ser-411, Ser-418, Thr-421, and Ser-424) in the autoinhibitory domain near the C terminus.	Proline	96-103	ribosomal protein S6 kinase B1	Homo sapiens	14-18
17217964-3	2007	This proline residue is widely conserved throughout the cystatin superfamily, a member of which, human cystatin C, is the key protein in cerebral amyloid angiopathy.	Proline	5-12	cystatin C	Homo sapiens	103-113
17349962-5	2007	The interaction with c-Src involves two domains of PMR1: Y650 and a series of proline-rich SH3 peptides in the N terminus.	Proline	78-85	ATPase, Ca++-sequestering	Mus musculus	51-55
17318189-3	2007	Here, we show that the C-terminal proline-rich domain of Hip1R binds to the SH3 domain of cortactin, a protein that binds to dynamin, actin filaments and the Arp2/3 complex.	Proline	34-41	huntingtin interacting protein 1 related	Homo sapiens	57-62
17318189-3	2007	Here, we show that the C-terminal proline-rich domain of Hip1R binds to the SH3 domain of cortactin, a protein that binds to dynamin, actin filaments and the Arp2/3 complex.	Proline	34-41	cortactin	Homo sapiens	90-99
17318189-3	2007	Here, we show that the C-terminal proline-rich domain of Hip1R binds to the SH3 domain of cortactin, a protein that binds to dynamin, actin filaments and the Arp2/3 complex.	Proline	34-41	actin related protein 2	Homo sapiens	158-162
17349962-5	2007	The interaction with c-Src involves two domains of PMR1: Y650 and a series of proline-rich SH3 peptides in the N terminus.	Proline	78-85	sperm hammerhead 3	Mus musculus	91-94
17338643-0	2007	Human dipeptidyl peptidase III acts as a post-proline-cleaving enzyme on endomorphins.	Proline	46-53	dipeptidyl peptidase 3	Homo sapiens	6-30
17188491-0	2007	Diastereoselective synthesis of glycosylated prolines as alpha-glucosidase inhibitors and organocatalyst in asymmetric aldol reaction.	Proline	45-53	sucrase-isomaltase	Homo sapiens	57-74
17306257-4	2007	A binding region of CIN85 SH3 domains on 3BP2 was mapped to a PVPTPR motif in the first proline-rich region of 3BP2, whereas the C-terminal SH3 domain of HIP-55 bound a more distal proline-rich domain of 3BP2.	Proline	88-95	SH3 domain containing kinase binding protein 1	Homo sapiens	20-25
17306257-4	2007	A binding region of CIN85 SH3 domains on 3BP2 was mapped to a PVPTPR motif in the first proline-rich region of 3BP2, whereas the C-terminal SH3 domain of HIP-55 bound a more distal proline-rich domain of 3BP2.	Proline	88-95	SH3 domain binding protein 2	Homo sapiens	41-45
17306257-4	2007	A binding region of CIN85 SH3 domains on 3BP2 was mapped to a PVPTPR motif in the first proline-rich region of 3BP2, whereas the C-terminal SH3 domain of HIP-55 bound a more distal proline-rich domain of 3BP2.	Proline	88-95	SH3 domain binding protein 2	Homo sapiens	111-115
17306257-4	2007	A binding region of CIN85 SH3 domains on 3BP2 was mapped to a PVPTPR motif in the first proline-rich region of 3BP2, whereas the C-terminal SH3 domain of HIP-55 bound a more distal proline-rich domain of 3BP2.	Proline	88-95	SH3 domain binding protein 2	Homo sapiens	111-115
17306257-4	2007	A binding region of CIN85 SH3 domains on 3BP2 was mapped to a PVPTPR motif in the first proline-rich region of 3BP2, whereas the C-terminal SH3 domain of HIP-55 bound a more distal proline-rich domain of 3BP2.	Proline	181-188	SH3 domain containing kinase binding protein 1	Homo sapiens	20-25
17306257-4	2007	A binding region of CIN85 SH3 domains on 3BP2 was mapped to a PVPTPR motif in the first proline-rich region of 3BP2, whereas the C-terminal SH3 domain of HIP-55 bound a more distal proline-rich domain of 3BP2.	Proline	181-188	drebrin like	Homo sapiens	154-160
17300591-3	2007	These drugs reversibly block DPP-IV-mediated inactivation of incretin hormones, for example, glucagon-like peptide 1 (GLP-1) and also other peptides that have alanine or proline as the penultimate N-terminal amino acid.	Proline	170-177	dipeptidyl peptidase 4	Homo sapiens	29-35
17295371-1	2007	Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy terminus.	Proline	70-77	prolyl endopeptidase	Homo sapiens	0-21
17260156-3	2007	To investigate the role of FoxG1 in forebrain evolution, we cloned and analyzed the cDNA sequences for nine new FoxG1 orthologues, including six mammals and three reptiles, and show that there is an extended proline and glutamine region in the N-terminal domain that is specific to mammals.	Proline	208-215	forkhead box G1	Homo sapiens	27-32
17081193-4	2007	We show that infection of enterocyte-like Caco-2/TC7 cells by rhesus monkey rotavirus (RRV) impairs the biosynthesis of dipeptidyl peptidase IV (DPP IV), an important hydrolase in the digestion of dietary proline-rich proteins.	Proline	205-212	dipeptidyl peptidase 4	Macaca mulatta	120-143
17081193-4	2007	We show that infection of enterocyte-like Caco-2/TC7 cells by rhesus monkey rotavirus (RRV) impairs the biosynthesis of dipeptidyl peptidase IV (DPP IV), an important hydrolase in the digestion of dietary proline-rich proteins.	Proline	205-212	dipeptidyl peptidase 4	Macaca mulatta	145-151
17383430-0	2007	Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis.	Proline	38-45	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
17383430-0	2007	Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis.	Proline	38-45	X protein	Hepatitis B virus	73-82
17383430-2	2007	Hepatitis B virus (HBV) is the most common etiologic agent in HCC, and its encoded X-protein (HBx) is oncogenic and possesses a serine-proline motif that may bind Pin1.	Proline	135-142	X protein	Hepatitis B virus	83-92
17179073-10	2007	Additionally, either Tsc1/2 or Tor1 are required for growth on a poor nitrogen source such as proline.	Proline	94-101	TSC complex subunit 1	Homo sapiens	21-25
17383430-2	2007	Hepatitis B virus (HBV) is the most common etiologic agent in HCC, and its encoded X-protein (HBx) is oncogenic and possesses a serine-proline motif that may bind Pin1.	Proline	135-142	X protein	Hepatitis B virus	94-97
17383430-2	2007	Hepatitis B virus (HBV) is the most common etiologic agent in HCC, and its encoded X-protein (HBx) is oncogenic and possesses a serine-proline motif that may bind Pin1.	Proline	135-142	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	163-167
17383430-7	2007	RESULTS: We showed preferential Pin1 overexpression in HBV-related tumors and confirmed the interaction between Pin1 and HBx at the specific serine-proline motif.	Proline	148-155	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	112-116
17383430-7	2007	RESULTS: We showed preferential Pin1 overexpression in HBV-related tumors and confirmed the interaction between Pin1 and HBx at the specific serine-proline motif.	Proline	148-155	X protein	Hepatitis B virus	121-124
17355867-2	2007	Pin1 recognizes phospho-Ser/Thr-Pro motifs in cell-signaling proteins, and is both a cancer and an Alzheimer"s disease target.	Proline	32-35	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
17312148-4	2007	Furthermore, these CD8alpha-like DNAs encode a distinct multigene family of immunoreceptors that have a charged or polar residue in place of the interspecies-conserved CD8alpha transmembrane proline residue and a short cytoplasmic tail nonhomologous to CD8alpha.	Proline	191-198	T-cell surface glycoprotein CD8 alpha chain	Gallus gallus	19-27
17311947-3	2007	GLP-2 infusion was hypothesized to increase the rate of endogenous arginine synthesis from proline, the major arginine precursor, in parenterally fed piglets receiving an arginine-deficient diet.	Proline	91-98	glucagon	Homo sapiens	0-5
17311947-7	2007	Piglets receiving GLP-2 showed improvements in intestinal variables, including mucosal mass (P &lt; 0.01) and villus height (P &lt; 0.001), and a greater rate of arginine synthesis (micromol x kg(-1) x h(-1)) from proline (11.6 vs. 6.3) (P = 0.03).	Proline	214-221	glucagon	Homo sapiens	18-23
17178840-6	2007	We define the proline residues in hnRNP K in the proline-rich motifs P2 (amino acids [aa] 285 to 297) and P3 (aa 303 to 318), which are necessary and sufficient for the specific activation of c-Src, and we dissect the amino acid sequence (aa 216 to 226) of hnRNP K that mediates a second interaction with c-Src.	Proline	14-21	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	34-41
17178840-6	2007	We define the proline residues in hnRNP K in the proline-rich motifs P2 (amino acids [aa] 285 to 297) and P3 (aa 303 to 318), which are necessary and sufficient for the specific activation of c-Src, and we dissect the amino acid sequence (aa 216 to 226) of hnRNP K that mediates a second interaction with c-Src.	Proline	14-21	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	192-197
17178840-6	2007	We define the proline residues in hnRNP K in the proline-rich motifs P2 (amino acids [aa] 285 to 297) and P3 (aa 303 to 318), which are necessary and sufficient for the specific activation of c-Src, and we dissect the amino acid sequence (aa 216 to 226) of hnRNP K that mediates a second interaction with c-Src.	Proline	14-21	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	257-264
17178840-6	2007	We define the proline residues in hnRNP K in the proline-rich motifs P2 (amino acids [aa] 285 to 297) and P3 (aa 303 to 318), which are necessary and sufficient for the specific activation of c-Src, and we dissect the amino acid sequence (aa 216 to 226) of hnRNP K that mediates a second interaction with c-Src.	Proline	14-21	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	305-310
17178840-6	2007	We define the proline residues in hnRNP K in the proline-rich motifs P2 (amino acids [aa] 285 to 297) and P3 (aa 303 to 318), which are necessary and sufficient for the specific activation of c-Src, and we dissect the amino acid sequence (aa 216 to 226) of hnRNP K that mediates a second interaction with c-Src.	Proline	49-56	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	34-41
17178840-6	2007	We define the proline residues in hnRNP K in the proline-rich motifs P2 (amino acids [aa] 285 to 297) and P3 (aa 303 to 318), which are necessary and sufficient for the specific activation of c-Src, and we dissect the amino acid sequence (aa 216 to 226) of hnRNP K that mediates a second interaction with c-Src.	Proline	49-56	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	192-197
17178840-6	2007	We define the proline residues in hnRNP K in the proline-rich motifs P2 (amino acids [aa] 285 to 297) and P3 (aa 303 to 318), which are necessary and sufficient for the specific activation of c-Src, and we dissect the amino acid sequence (aa 216 to 226) of hnRNP K that mediates a second interaction with c-Src.	Proline	49-56	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	257-264
17178840-6	2007	We define the proline residues in hnRNP K in the proline-rich motifs P2 (amino acids [aa] 285 to 297) and P3 (aa 303 to 318), which are necessary and sufficient for the specific activation of c-Src, and we dissect the amino acid sequence (aa 216 to 226) of hnRNP K that mediates a second interaction with c-Src.	Proline	49-56	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	305-310
17493154-3	2007	At the protein level, these substitutions result in a change of a single amino acid residue in each of HLA-B*3569 and -B*4450 at positions 74 (Arg &gt; Pro) and 80 (Thr &gt; Ile), respectively.	Proline	152-155	major histocompatibility complex, class I, B	Homo sapiens	103-108
17192295-5	2007	RESULTS: Four homozygote mutations were identified by direct sequencing of the CYP17A1 gene corresponding to an alanin 302-proline (A302P) exchange; the loss of lysine 327 (K327del); the deletion of glutamate 331 (E331del); and the replacement of arginine 416 with a histidine (R416H).	Proline	123-130	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	79-86
17182673-3	2007	The amino-terminal and central proline-rich motifs of STP-A were responsible for TRAF6 and TRAF2 interactions, respectively, and STP-A and TRAF6 interaction contributed to the majority of NF-kappaB activation, whereas STP-A and TRAF2 interaction played a minor role in NF-kappaB activation.	Proline	31-38	sulfotransferase family 1A member 1	Homo sapiens	54-57
17182673-3	2007	The amino-terminal and central proline-rich motifs of STP-A were responsible for TRAF6 and TRAF2 interactions, respectively, and STP-A and TRAF6 interaction contributed to the majority of NF-kappaB activation, whereas STP-A and TRAF2 interaction played a minor role in NF-kappaB activation.	Proline	31-38	TNF receptor associated factor 6	Homo sapiens	81-86
17182673-3	2007	The amino-terminal and central proline-rich motifs of STP-A were responsible for TRAF6 and TRAF2 interactions, respectively, and STP-A and TRAF6 interaction contributed to the majority of NF-kappaB activation, whereas STP-A and TRAF2 interaction played a minor role in NF-kappaB activation.	Proline	31-38	TNF receptor associated factor 2	Homo sapiens	91-96
17182674-6	2007	Yeast-two hybrid assays were used to identify two new and independent Tsg101 binding sites, one in the Hrs coiled-coil domain and one in the proline/glutamic acid-rich domain.	Proline	141-148	tumor susceptibility 101	Homo sapiens	70-76
17051390-3	2007	In Ussing chamber experiments, glucose (20 mM), phenylalanine (20 mM), glutamine (20 mM), cysteine (20 mM), and proline (20 mM) generated lumen negative currents (I (glc), I (phe), I (gln), I (cys), and I (pro)), respectively, which gradually declined following application of the PI3 kinase inhibitor Wortmannin (1 muM).	Proline	112-119	latexin	Homo sapiens	316-319
17123829-7	2007	But, in the case of GST with Pro as the antepenultimate residue, the efficiency was significantly reduced when the penultimate residue was Gly or Thr.	Proline	29-32	glutathione S-transferase	Triticum aestivum	20-23
17297930-8	2007	In certain configurations, cleavage products are produced in less than 10 s. Reproducible product patterns consistent with cleavage of the peptide bond at proline for angiotensin I, Lys-bradykinin, and myoglobin are demonstrated using capillary electrophoresis.	Proline	155-162	angiotensinogen	Homo sapiens	167-180
17307877-7	2007	The different conformations of the loop, which connects the polo boxes in the apo and the PBD-Cdc25C and PBD-Cdc25C-P complex structures, together with changes in the proline adjacent to the phosphothreonine in the target peptide, suggest a regulatory mechanism to detect binding of unphosphorylated or phosphorylated target substrates.	Proline	167-174	cell division cycle 25C	Homo sapiens	94-100
17307877-7	2007	The different conformations of the loop, which connects the polo boxes in the apo and the PBD-Cdc25C and PBD-Cdc25C-P complex structures, together with changes in the proline adjacent to the phosphothreonine in the target peptide, suggest a regulatory mechanism to detect binding of unphosphorylated or phosphorylated target substrates.	Proline	167-174	cell division cycle 25C	Homo sapiens	109-115
17297930-8	2007	In certain configurations, cleavage products are produced in less than 10 s. Reproducible product patterns consistent with cleavage of the peptide bond at proline for angiotensin I, Lys-bradykinin, and myoglobin are demonstrated using capillary electrophoresis.	Proline	155-162	kininogen 1	Homo sapiens	186-196
17158461-3	2007	The proline-rich region and regions near the second 8-cysteine domain in fibrillin-1 were easily cleaved by crude collagenase.	Proline	4-11	fibrillin 1	Homo sapiens	73-84
17158452-0	2007	Assembly of acetylcholinesterase tetramers by peptidic motifs from the proline-rich membrane anchor, PRiMA: competition between degradation and secretion pathways of heteromeric complexes.	Proline	71-78	acetylcholinesterase (Cartwright blood group)	Homo sapiens	12-32
17158452-0	2007	Assembly of acetylcholinesterase tetramers by peptidic motifs from the proline-rich membrane anchor, PRiMA: competition between degradation and secretion pathways of heteromeric complexes.	Proline	71-78	proline rich membrane anchor 1	Homo sapiens	101-106
17158452-8	2007	Interestingly, short PRiMA mutants, truncated within the proline-rich motif, reduced both cellular and secreted AChE activity, suggesting that their interaction with AChE(T) subunits induces their intracellular degradation.	Proline	57-64	proline rich membrane anchor 1	Homo sapiens	21-26
17158452-2	2007	These molecules are hetero-oligomers, composed of four AChE catalytic subunits of type T (AChE(T)), associated with a transmembrane protein of type 1, called PRiMA (proline-rich membrane anchor).	Proline	165-172	proline rich membrane anchor 1	Homo sapiens	158-163
17158452-3	2007	PRiMA consists of a signal peptide, an extracellular domain that contains a proline-rich motif (14 prolines with an intervening leucine, P4LP10), a transmembrane domain, and a cytoplasmic domain.	Proline	76-83	proline rich membrane anchor 1	Homo sapiens	0-5
17158452-3	2007	PRiMA consists of a signal peptide, an extracellular domain that contains a proline-rich motif (14 prolines with an intervening leucine, P4LP10), a transmembrane domain, and a cytoplasmic domain.	Proline	99-107	proline rich membrane anchor 1	Homo sapiens	0-5
17158452-8	2007	Interestingly, short PRiMA mutants, truncated within the proline-rich motif, reduced both cellular and secreted AChE activity, suggesting that their interaction with AChE(T) subunits induces their intracellular degradation.	Proline	57-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	112-116
17289588-3	2007	We find that a proline on the linker tethering the two SH3 domains of the Crk adaptor protein interconverts between the cis and trans conformation.	Proline	15-22	CRK proto-oncogene, adaptor protein	Homo sapiens	74-77
17158452-8	2007	Interestingly, short PRiMA mutants, truncated within the proline-rich motif, reduced both cellular and secreted AChE activity, suggesting that their interaction with AChE(T) subunits induces their intracellular degradation.	Proline	57-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	166-170
17145134-3	2007	Among those genes is DYRK1A encoding dual-specificity proline-directed serine/treonine kinase, which, as documented by animal studies, can potentially contribute to cognitive deficits in DS.	Proline	54-61	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	21-27
17121859-5	2007	The properties that permit GLRX2, and not other glutaredoxins, to form an iron-sulfur-containing dimer are likely due to the proline-to-serine substitution in the active site motif, allowing the main chain more flexibility in this area and providing polar interaction with the stabilizing glutathione.	Proline	125-132	glutaredoxin 2	Homo sapiens	27-32
17223878-1	2007	BACKGROUND: p53 has a common polymorphism at amino acid 72, encoding either arginine or proline.	Proline	88-95	tumor protein p53	Homo sapiens	12-15
17118402-0	2007	Crystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifs.	Proline	125-132	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	57-60
17118402-8	2007	Moreover, upon addition of a proline-rich peptide with a sequence corresponding to the recognition segment of the herpesviral regulatory protein Tip, competition between zinc-induced homodimerization and binding of the peptide can be detected by both fluorescence spectroscopy and analytical ultracentrifugation.	Proline	29-36	TOR signaling pathway regulator	Homo sapiens	145-148
17118402-9	2007	These results suggest that in vivo, too, competition between Lck-SH3 homodimerization and binding of regulatory proline-rich sequence motifs possibly represents a novel mechanism by which kinase activity is modulated.	Proline	112-119	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	61-64
17212354-4	2007	RpL23a proteins in Aedes and Anopheles mosquitoes are rich in lysine (approximately 25%), alanine (approximately 21%), and proline (approximately 8%), have a mass of approximately 40 kDa, a pI of 11.4 to 11.5, and contain an N-terminal extension of approximately 260 amino acid residues.	Proline	123-130	Ribosomal protein L23A	Drosophila melanogaster	0-6
17261087-6	2007	Furthermore, the 33-residue C-terminal peptide of human megsin, which carries a naturally occurring His-Pro-Phe sequence, was cleaved by renin at the C-terminal side of the His-Pro-Phe-Leu-Phe sequence.	Proline	104-107	serpin family B member 7	Homo sapiens	56-62
17261087-6	2007	Furthermore, the 33-residue C-terminal peptide of human megsin, which carries a naturally occurring His-Pro-Phe sequence, was cleaved by renin at the C-terminal side of the His-Pro-Phe-Leu-Phe sequence.	Proline	104-107	renin	Homo sapiens	137-142
17261087-8	2007	By binding to a corresponding pocket on renin, the His-Pro-Phe motif may act as a molecular anchor to recruit the scissile peptide bond to a favorable site for catalysis.	Proline	55-58	renin	Homo sapiens	40-45
17113302-4	2007	We report the synthesis of new Grb2 ligands in which the key Val5 residue has been replaced by a cis C(beta)-substituted proline.	Proline	121-128	growth factor receptor bound protein 2	Homo sapiens	31-35
17113777-2	2007	The results suggest that phenylglycine might be capable of interacting with the NS3 (protease-helicase/NTPase) in ways not possible for the common P2 proline-based inhibitors.	Proline	150-157	KRAS proto-oncogene, GTPase	Homo sapiens	80-83
17113777-2	2007	The results suggest that phenylglycine might be capable of interacting with the NS3 (protease-helicase/NTPase) in ways not possible for the common P2 proline-based inhibitors.	Proline	150-157	inosine triphosphatase	Homo sapiens	103-109
17141806-1	2007	We studied the interaction of hematopoietic cell kinase SH3 domain (HckSH3) with an artificial 12-residue proline-rich peptide PD1 (HSKYPLPPLPSL) identified as high affinity ligand (K(D)=0.2 muM).	Proline	106-113	programmed cell death 1	Homo sapiens	127-130
17261087-2	2007	We investigated whether this His-Pro-Phe motif functions as the determinant of the substrate specificity of renin.	Proline	33-36	renin	Homo sapiens	108-113
17261087-3	2007	Mutant angiotensinogens in which the Ile-His-Pro-Phe-His-Leu sequence at positions 5-10 of wild-type angiotensinogen was replaced by either His-Pro-Phe-His-Leu-Leu or Ala-Ile-His-Pro-Phe-His were cleaved by renin at the C-terminal side of residues 9 and 11, respectively, while wild-type angiotensinogen was cleaved at residue 10.	Proline	45-48	angiotensinogen	Homo sapiens	7-22
17179092-8	2007	cDNA and genomic DNA sequences of Il7 revealed a T-to-C missense transition resulting in a change of Leu to Pro within the leader peptide that would be predicted to inhibit secretion.	Proline	108-111	interleukin 7	Mus musculus	34-37
17160352-2	2007	The most well studied PEP family has a two-domain structure whose unique seven-blade beta-propeller domain works with the catalytic domain to hydrolyze the peptide bond on the carboxyl side of internal proline residues of an oligopeptide substrate.	Proline	202-209	prolyl endopeptidase	Homo sapiens	22-25
17160352-6	2007	Recently, microbial PEPs have been studied as potential therapeutics for celiac sprue, an inflammatory disease of the small intestine triggered by proline-rich gluten.	Proline	147-154	leucine aminopeptidase 3	Homo sapiens	20-24
17206105-1	2007	We have recently isolated a gene, Ankyrin-repeated protein with a proline-rich region (ARPP), that is highly expressed in the skeletal and cardiac muscle.	Proline	66-73	ankyrin repeat domain 2	Homo sapiens	87-91
17158931-0	2007	Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression.	Proline	72-79	transformation related protein 53, pseudogene	Mus musculus	68-71
17290187-7	2007	RESULTS: We demonstrate that malcavernin independently binds to two of the three NPXY (asparagine, proline, undetermined/variable amino acid, and tyrosine) motifs in krit1.	Proline	99-106	CCM2 scaffold protein	Homo sapiens	29-40
17158931-1	2007	The stability and activity of tumor suppressor p53 are tightly regulated and partially depend on the p53 proline-rich domain (PRD).	Proline	105-112	transformation related protein 53, pseudogene	Mus musculus	47-50
17158931-1	2007	The stability and activity of tumor suppressor p53 are tightly regulated and partially depend on the p53 proline-rich domain (PRD).	Proline	105-112	transformation related protein 53, pseudogene	Mus musculus	101-104
17208335-9	2007	In the mouse brain, the Y1/Y4/Y5 agonist Leu(31),Pro(34)-NPY increased [(35)S]GTPgammaS binding with a regional distribution consistent with that produced when labeling adjacent sections with [(125)I]-Leu(31),Pro(34)-PYY.	Proline	49-52	neuropeptide Y	Mus musculus	57-60
17208335-9	2007	In the mouse brain, the Y1/Y4/Y5 agonist Leu(31),Pro(34)-NPY increased [(35)S]GTPgammaS binding with a regional distribution consistent with that produced when labeling adjacent sections with [(125)I]-Leu(31),Pro(34)-PYY.	Proline	49-52	peptide YY	Mus musculus	217-220
17208335-9	2007	In the mouse brain, the Y1/Y4/Y5 agonist Leu(31),Pro(34)-NPY increased [(35)S]GTPgammaS binding with a regional distribution consistent with that produced when labeling adjacent sections with [(125)I]-Leu(31),Pro(34)-PYY.	Proline	209-212	neuropeptide Y	Mus musculus	57-60
16978157-1	2007	The mammalian adaptor protein Alix [ALG-2 (apoptosis-linked-gene-2 product)-interacting protein X] belongs to a conserved family of proteins that have in common an N-terminal Bro1 domain and a C-terminal PRD (proline-rich domain), both of which mediate partner protein interactions.	Proline	209-216	programmed cell death 6 interacting protein	Homo sapiens	30-34
17189480-5	2007	The activity of Src, PI3, and Itk kinases, for example, is regulated by intramolecular interactions between their SH3 domain and internal proline-rich sequences.	Proline	138-145	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	16-19
17189480-5	2007	The activity of Src, PI3, and Itk kinases, for example, is regulated by intramolecular interactions between their SH3 domain and internal proline-rich sequences.	Proline	138-145	peptidase inhibitor 3	Homo sapiens	21-24
17189480-5	2007	The activity of Src, PI3, and Itk kinases, for example, is regulated by intramolecular interactions between their SH3 domain and internal proline-rich sequences.	Proline	138-145	IL2 inducible T cell kinase	Homo sapiens	30-33
17113103-6	2007	Proline mutants were used to show that the minor kinetic phases observed for myotrophin arise from heterogeneity of the ground states due to cis-trans isomerisation of prolyl as well as non-prolyl peptide bonds.	Proline	0-7	myotrophin	Homo sapiens	77-87
17121855-1	2007	Cdk5 is a proline-directed Ser/Thr protein kinase predominantly expressed in postmitotic neurons together with its activator, p35.	Proline	10-17	cyclin-dependent kinase 5	Rattus norvegicus	0-4
17121855-1	2007	Cdk5 is a proline-directed Ser/Thr protein kinase predominantly expressed in postmitotic neurons together with its activator, p35.	Proline	10-17	cyclin-dependent kinase 5 regulatory subunit 1	Rattus norvegicus	126-129
16978157-1	2007	The mammalian adaptor protein Alix [ALG-2 (apoptosis-linked-gene-2 product)-interacting protein X] belongs to a conserved family of proteins that have in common an N-terminal Bro1 domain and a C-terminal PRD (proline-rich domain), both of which mediate partner protein interactions.	Proline	209-216	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	36-41
17228057-4	2007	A proline-rich module from Ssdp1 is likely responsible for transactivation, and this region is curiously mobile, occurring in different proteins in different species.	Proline	2-9	single stranded DNA binding protein 3	Homo sapiens	27-32
17174262-0	2007	HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions.	Proline	102-109	protein tyrosine phosphatase non-receptor type 23	Homo sapiens	0-6
17174262-0	2007	HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions.	Proline	102-109	programmed cell death 6 interacting protein	Homo sapiens	11-15
17174262-2	2007	HD-PTP is a paralog of Alix and a putative protein tyrosine phosphatase (PTP) that contains a Bro1 domain, coiled-coils, a proline-rich region (PRR) in addition to a PTP domain.	Proline	123-130	protein tyrosine phosphatase non-receptor type 23	Homo sapiens	0-6
17174262-2	2007	HD-PTP is a paralog of Alix and a putative protein tyrosine phosphatase (PTP) that contains a Bro1 domain, coiled-coils, a proline-rich region (PRR) in addition to a PTP domain.	Proline	123-130	programmed cell death 6 interacting protein	Homo sapiens	23-27
17174262-2	2007	HD-PTP is a paralog of Alix and a putative protein tyrosine phosphatase (PTP) that contains a Bro1 domain, coiled-coils, a proline-rich region (PRR) in addition to a PTP domain.	Proline	123-130	protein tyrosine phosphatase receptor type U	Homo sapiens	3-6
17174262-2	2007	HD-PTP is a paralog of Alix and a putative protein tyrosine phosphatase (PTP) that contains a Bro1 domain, coiled-coils, a proline-rich region (PRR) in addition to a PTP domain.	Proline	123-130	protein tyrosine phosphatase receptor type U	Homo sapiens	73-76
17113301-3	2007	To discover a structure for the gamma-substituent of the proline moiety more suitable for interacting with the S(2) pocket of DPP-IV, optimization focused on the gamma-substituent was carried out.	Proline	57-64	dipeptidyl peptidase 4	Homo sapiens	126-132
17113301-6	2007	Indoline compounds such as 22e have a rigid conformation with double restriction of the aromatic moiety by proline and indoline structures to promote interaction with the binding site in the S(2) pocket of DPP-IV.	Proline	107-114	dipeptidyl peptidase 4	Homo sapiens	206-212
17202356-5	2007	Both structures confirm the presence of an absolutely conserved proline anchor residue in the P3 position of the Ag, bound to a D pocket of the Mamu-A*01 H chain with optimal surface complementarity.	Proline	64-71	major histocompatibility complex, class I, A	Macaca mulatta	144-150
17098236-2	2007	The medaka ppTRH cDNA codes for 270 amino acid residues including eight TRH progenitor sequences (-Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg-).	Proline	119-122	thyrotropin-releasing hormone	Oryzias latipes	11-16
17352682-2	2007	This review will mainly focus on proline-specific dipeptidyl peptidases related to DPP IV: fibroblast activation protein (FAP), dipeptidyl peptidase 8 (DPP8), dipeptidyl peptidase 9 (DPP9) and dipeptidyl peptidase II (DPP II).	Proline	33-40	dipeptidyl peptidase 4	Homo sapiens	83-89
17085439-0	2007	Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets.	Proline	167-174	glycoprotein VI platelet	Homo sapiens	121-145
17184580-12	2007	In vitro, 5 x 10(-9 )-5 x 10(-7 ) mol/L UII stimulated [3H]thymidine/[3H] proline incorporation into cardiac fibroblasts in a dose-dependent manner (P&lt; 0.01).	Proline	74-81	urotensin 2	Rattus norvegicus	40-43
17220689-8	2007	On the other hand, Pro/Pro males showed higher values of HDL cholesterol (47 +/- 8 vs 43 +/- 9 mg/dL, P = 0.001), lower total cholesterol/HDL ratio (4.04 +/- 0.59 vs 4.45 +/- 0.61, P = 0.031), lower values of apoB (59.8 +/- 11.3 vs 66.8 +/- 6.6 mg/dL, P = 0.007) and lower values of apoB/apoA1 ratio (0.41 +/- 0.09 vs 0.48 +/- 0.08, P = 0.019) compared with Pro/Ala.	Proline	19-22	apolipoprotein B	Homo sapiens	209-213
17220689-8	2007	On the other hand, Pro/Pro males showed higher values of HDL cholesterol (47 +/- 8 vs 43 +/- 9 mg/dL, P = 0.001), lower total cholesterol/HDL ratio (4.04 +/- 0.59 vs 4.45 +/- 0.61, P = 0.031), lower values of apoB (59.8 +/- 11.3 vs 66.8 +/- 6.6 mg/dL, P = 0.007) and lower values of apoB/apoA1 ratio (0.41 +/- 0.09 vs 0.48 +/- 0.08, P = 0.019) compared with Pro/Ala.	Proline	19-22	apolipoprotein B	Homo sapiens	283-287
17220689-8	2007	On the other hand, Pro/Pro males showed higher values of HDL cholesterol (47 +/- 8 vs 43 +/- 9 mg/dL, P = 0.001), lower total cholesterol/HDL ratio (4.04 +/- 0.59 vs 4.45 +/- 0.61, P = 0.031), lower values of apoB (59.8 +/- 11.3 vs 66.8 +/- 6.6 mg/dL, P = 0.007) and lower values of apoB/apoA1 ratio (0.41 +/- 0.09 vs 0.48 +/- 0.08, P = 0.019) compared with Pro/Ala.	Proline	19-22	apolipoprotein A1	Homo sapiens	288-293
17265103-4	2007	Among the five NSP4 genotypes identified, those belonging to genotypes A1, B and C possess either a proline at position 138 or a glycine at 140, while those of A2, D and E lack these residues in the ISVD, suggesting conformational differences in this region among different NSP4s.	Proline	100-107	serine protease 57	Homo sapiens	15-19
17266558-4	2007	In this study we have focused on the proline rich p1-p6(Gag) C-terminus of HIV-1.	Proline	37-44	Pr55(Gag)	Human immunodeficiency virus 1	56-59
17266558-10	2007	The p1 proline residues were found to be functionally distinct from P24, P25 and P30 in p6(Gag).	Proline	7-14	Pr55(Gag)	Human immunodeficiency virus 1	91-94
17352682-2	2007	This review will mainly focus on proline-specific dipeptidyl peptidases related to DPP IV: fibroblast activation protein (FAP), dipeptidyl peptidase 8 (DPP8), dipeptidyl peptidase 9 (DPP9) and dipeptidyl peptidase II (DPP II).	Proline	33-40	fibroblast activation protein alpha	Homo sapiens	91-120
17352682-2	2007	This review will mainly focus on proline-specific dipeptidyl peptidases related to DPP IV: fibroblast activation protein (FAP), dipeptidyl peptidase 8 (DPP8), dipeptidyl peptidase 9 (DPP9) and dipeptidyl peptidase II (DPP II).	Proline	33-40	fibroblast activation protein alpha	Homo sapiens	122-125
17352682-2	2007	This review will mainly focus on proline-specific dipeptidyl peptidases related to DPP IV: fibroblast activation protein (FAP), dipeptidyl peptidase 8 (DPP8), dipeptidyl peptidase 9 (DPP9) and dipeptidyl peptidase II (DPP II).	Proline	33-40	dipeptidyl peptidase 8	Homo sapiens	128-150
17352682-2	2007	This review will mainly focus on proline-specific dipeptidyl peptidases related to DPP IV: fibroblast activation protein (FAP), dipeptidyl peptidase 8 (DPP8), dipeptidyl peptidase 9 (DPP9) and dipeptidyl peptidase II (DPP II).	Proline	33-40	dipeptidyl peptidase 8	Homo sapiens	152-156
17352682-2	2007	This review will mainly focus on proline-specific dipeptidyl peptidases related to DPP IV: fibroblast activation protein (FAP), dipeptidyl peptidase 8 (DPP8), dipeptidyl peptidase 9 (DPP9) and dipeptidyl peptidase II (DPP II).	Proline	33-40	dipeptidyl peptidase 9	Homo sapiens	159-181
17762207-1	2007	Glycine 2-methyl proline glutamate (G-2mPE) is a proline-modified analogue to the naturally existing N-terminal tripeptide glycine-proline-glutamate that is a cleaved product from insulin-like growth factor-1.	Proline	17-24	insulin-like growth factor 1	Rattus norvegicus	180-208
17352682-2	2007	This review will mainly focus on proline-specific dipeptidyl peptidases related to DPP IV: fibroblast activation protein (FAP), dipeptidyl peptidase 8 (DPP8), dipeptidyl peptidase 9 (DPP9) and dipeptidyl peptidase II (DPP II).	Proline	33-40	dipeptidyl peptidase 9	Homo sapiens	183-187
17352682-2	2007	This review will mainly focus on proline-specific dipeptidyl peptidases related to DPP IV: fibroblast activation protein (FAP), dipeptidyl peptidase 8 (DPP8), dipeptidyl peptidase 9 (DPP9) and dipeptidyl peptidase II (DPP II).	Proline	33-40	dipeptidyl peptidase 7	Homo sapiens	193-216
17352682-2	2007	This review will mainly focus on proline-specific dipeptidyl peptidases related to DPP IV: fibroblast activation protein (FAP), dipeptidyl peptidase 8 (DPP8), dipeptidyl peptidase 9 (DPP9) and dipeptidyl peptidase II (DPP II).	Proline	33-40	dipeptidyl peptidase 7	Homo sapiens	218-224
17382552-7	2007	RESULTS: A concentration-dependent stimulation of DNA, PG, collagen and NO synthesis was obtained when cells were incubated with ET-1 for 24-h. Eighteen-month old chondrocytes incorporated per microg DNA more [3H]thymidine, 35SO4 and [3H]proline but less NO when challenged with ET-1 than the 1-month old cells.	Proline	238-245	endothelin 1	Homo sapiens	129-133
17241154-6	2007	Phosphorylated APP is a Pin1 substrate, which binds to its phosphor-Thr668-Pro motif.	Proline	75-78	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	24-28
21901058-1	2007	Cyclophilin (CyP) is a peptidyl prolyl cis/trans isomerase, catalyzing the cis-trans isomerization of proline residues in proteins.	Proline	102-109	peptidylprolyl isomerase G	Homo sapiens	0-11
21901058-1	2007	Cyclophilin (CyP) is a peptidyl prolyl cis/trans isomerase, catalyzing the cis-trans isomerization of proline residues in proteins.	Proline	102-109	peptidylprolyl isomerase G	Homo sapiens	13-16
17284929-0	2007	Lys, pro and trp are critical core amino acid residues recognized by FUM20, a monoclonal antibody against serine protease pan-fungal allergens.	Proline	5-8	coagulation factor II, thrombin	Homo sapiens	106-121
17284929-14	2007	CONCLUSIONS: The lysine, proline and tryptophan residues located on the N-terminal region of fungal serine proteases are critical core amino acid residues recognized by FUM20, a monoclonal antibody against serine protease pan-fungal allergens.	Proline	25-32	coagulation factor II, thrombin	Homo sapiens	100-115
17387579-7	2007	Interestingly, locus 5 is 6.2 kb upstream of a late cornified envelope-like proline-rich 1 (LELP1) gene which encodes a novel small proline rich protein.	Proline	76-83	late cornified envelope like proline rich 1	Homo sapiens	92-97
17313147-2	2007	The resulting mixed-mode CSP Chirasil-Val(gamma-Dex) 3 was found to have a greatly improved enantioselectivity toward proline and aspartic acid (as N-trifluoroacetyl ethyl or methyl esters) in comparison to the single-mode CSP 2.	Proline	118-125	regulator of calcineurin 2	Homo sapiens	223-228
17998070-5	2007	This work has implicated a novel role for proline and asparagine hydroxylases in the modulation of NF-kappaB activity.	Proline	42-49	nuclear factor kappa B subunit 1	Homo sapiens	99-108
16874462-1	2007	Proline oxidase (POX), a mitochondrial inner-membrane protein, catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C).	Proline	104-111	proline dehydrogenase 1	Homo sapiens	0-15
16874462-1	2007	Proline oxidase (POX), a mitochondrial inner-membrane protein, catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C).	Proline	104-111	proline dehydrogenase 1	Homo sapiens	17-20
16874462-1	2007	Proline oxidase (POX), a mitochondrial inner-membrane protein, catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C).	Proline	104-111	inner membrane mitochondrial protein	Homo sapiens	25-61
16874462-1	2007	Proline oxidase (POX), a mitochondrial inner-membrane protein, catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C).	Proline	104-111	pyrroline-5-carboxylate reductase 1	Homo sapiens	141-144
16874462-4	2007	To further investigate the molecular basis of POX-induced apoptosis, we utilized the DLD-1.POX cells to show that cells overproducing POX exhibit an L-proline-dependent apoptotic response.	Proline	149-158	proline dehydrogenase 1	Homo sapiens	46-49
16874462-4	2007	To further investigate the molecular basis of POX-induced apoptosis, we utilized the DLD-1.POX cells to show that cells overproducing POX exhibit an L-proline-dependent apoptotic response.	Proline	149-158	proline dehydrogenase 1	Homo sapiens	91-94
16874462-4	2007	To further investigate the molecular basis of POX-induced apoptosis, we utilized the DLD-1.POX cells to show that cells overproducing POX exhibit an L-proline-dependent apoptotic response.	Proline	149-158	proline dehydrogenase 1	Homo sapiens	91-94
16874462-5	2007	The apoptotic effect is specific for L-proline, detectable at 0.2 mM, maximal at 1 mM, and occurs during 48-72 h following the addition of L-proline to cells with maximally induced POX.	Proline	37-46	proline dehydrogenase 1	Homo sapiens	181-184
16874462-5	2007	The apoptotic effect is specific for L-proline, detectable at 0.2 mM, maximal at 1 mM, and occurs during 48-72 h following the addition of L-proline to cells with maximally induced POX.	Proline	139-148	proline dehydrogenase 1	Homo sapiens	181-184
16874462-7	2007	We conclude that in the presence of proline, high POX activity is sufficient to induce mitochondria-mediated apoptosis.	Proline	36-43	proline dehydrogenase 1	Homo sapiens	50-53
17265460-7	2007	Furthermore, infusions of [Leu(31) Pro(34)]PYY (a Y1 and Y5 receptor agonist) alone and BIIE0246 alone into the CA3 region produced the antidepressant-like effects in LH rats.	Proline	35-38	neuropeptide Y receptor Y5	Rattus norvegicus	48-68
17164290-2	2007	Previous studies identified a proline-rich domain in the cytoplasmic tail required for sorting FasL to secretory lysosomes, but the mechanisms by which this occurs have not been identified.	Proline	30-37	Fas ligand	Homo sapiens	95-99
17070587-9	2007	Proline 391 is not only within the functionally important catalytic domain, but is also a phylogenetically conserved amino acid residue among GRK1 orthologs and homologs.	Proline	0-7	G protein-coupled receptor kinase 1	Homo sapiens	142-146
17319790-11	2007	In the younger women group, the p53 BstUI polymorphism genotype frequencies were 6.2% for BstUIPro/Pro, 31.0% for BstUIArg/Pro and 62.8% for BstUIArg/Arg in controls and 11.11 %, 40.74% and 48.15% in cases respectively.	Proline	95-98	tumor protein p53	Homo sapiens	32-35
17169985-1	2007	Glucocorticoid-induced leucine zipper (GILZ) is a 137 amino acid protein, rapidly induced by treatment with glucocorticoids (GC), characterized by a leucine zipper (LZ) domain (76-97 amino acids), an N-terminal domain (1-75 amino acids) and a C-terminal PER domain (98-137 amino acids) rich in proline and glutamic acid residues.	Proline	294-301	TSC22 domain family member 3	Homo sapiens	0-37
17169985-1	2007	Glucocorticoid-induced leucine zipper (GILZ) is a 137 amino acid protein, rapidly induced by treatment with glucocorticoids (GC), characterized by a leucine zipper (LZ) domain (76-97 amino acids), an N-terminal domain (1-75 amino acids) and a C-terminal PER domain (98-137 amino acids) rich in proline and glutamic acid residues.	Proline	294-301	TSC22 domain family member 3	Homo sapiens	39-43
17518591-0	2007	Monocytic U937 adhesion, tumor necrosis factor-alpha and interleukin-1 beta expression in response to gelatin-based networks grafted with arginine-glycine-aspartic acid and proline-histidine-serine-arginine-asparagine oligopeptides.	Proline	173-180	interleukin 1 beta	Homo sapiens	57-75
17097615-1	2006	MNB/DYRK1A is a proline-directed serine/threonine kinase implicated in Down syndrome (DS).	Proline	16-23	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	0-3
17065151-0	2006	Structure of FBP11 WW1-PL ligand complex reveals the mechanism of proline-rich ligand recognition by group II/III WW domains.	Proline	66-73	pre-mRNA processing factor 40 homolog A	Homo sapiens	13-18
17065151-8	2006	The Pro and Leu residues in the ligand interact with the grooves and the Loop I region of FBP11 WW1, respectively, which are necessary interactions for binding the ligand.	Proline	4-7	pre-mRNA processing factor 40 homolog A	Homo sapiens	90-95
17065151-9	2006	Interestingly, the two aromatic grooves recognize the Pro residues in entirely different manners, which allows FBP11 WW1 to recognize shorter sequences than the SH3 domain.	Proline	54-57	pre-mRNA processing factor 40 homolog A	Homo sapiens	111-116
17097615-1	2006	MNB/DYRK1A is a proline-directed serine/threonine kinase implicated in Down syndrome (DS).	Proline	16-23	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	4-10
17179858-3	2006	By denaturing high-performance liquid chromatography and gene sequencing in patients and controls, we identified a novel frequent heterozygous 2264C-->T substitution, which causes a proline-to-leucine mutation (P755L) in LRRK2 gene.	Proline	182-189	leucine rich repeat kinase 2	Homo sapiens	221-226
17176070-0	2006	Functional role of the conserved active site proline of triosephosphate isomerase.	Proline	45-52	triosephosphate isomerase 1	Homo sapiens	56-81
17176070-1	2006	The importance of the fully conserved active site proline, Pro168, for the reaction mechanism of triosephosphate isomerase (TIM) has been investigated by studying the enzymatic and crystallographic properties of the P168A variant of trypanosomal TIM.	Proline	50-57	triosephosphate isomerase 1	Homo sapiens	97-122
17176070-1	2006	The importance of the fully conserved active site proline, Pro168, for the reaction mechanism of triosephosphate isomerase (TIM) has been investigated by studying the enzymatic and crystallographic properties of the P168A variant of trypanosomal TIM.	Proline	50-57	triosephosphate isomerase 1	Homo sapiens	124-127
17176070-6	2006	The unique properties of the proline side chain at position 168 are required to transmit ligand binding to the conformational change of Glu167: the side chain of Glu167 flips from the inactive swung-out to the active swung-in conformation on ligand binding in wild-type TIM, whereas in the mutant this conformational change does not occur.	Proline	29-36	triosephosphate isomerase 1	Homo sapiens	270-273
17057225-1	2006	Proline- and acid-rich (PAR) basic region leucine zipper (bZIP) proteins thyrotroph embryonic factor (TEF), D-site-binding protein (DBP), and hepatic leukemia factor have been involved in neurotransmitter homeostasis and amino acid metabolism.	Proline	0-7	TEF transcription factor, PAR bZIP family member	Homo sapiens	73-100
17038311-0	2006	Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation.	Proline	0-7	parathyroid hormone	Homo sapiens	27-46
17038311-0	2006	Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation.	Proline	0-7	parathyroid hormone	Homo sapiens	48-51
17038311-0	2006	Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation.	Proline	0-7	parathyroid hormone	Homo sapiens	53-56
17038311-0	2006	Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation.	Proline	0-7	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	116-121
17038311-0	2006	Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation.	Proline	0-7	arrestin beta 2	Homo sapiens	127-141
17057225-1	2006	Proline- and acid-rich (PAR) basic region leucine zipper (bZIP) proteins thyrotroph embryonic factor (TEF), D-site-binding protein (DBP), and hepatic leukemia factor have been involved in neurotransmitter homeostasis and amino acid metabolism.	Proline	0-7	TEF transcription factor, PAR bZIP family member	Homo sapiens	102-105
17038311-0	2006	Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation.	Proline	0-7	mitogen-activated protein kinase 3	Homo sapiens	146-152
17057225-1	2006	Proline- and acid-rich (PAR) basic region leucine zipper (bZIP) proteins thyrotroph embryonic factor (TEF), D-site-binding protein (DBP), and hepatic leukemia factor have been involved in neurotransmitter homeostasis and amino acid metabolism.	Proline	0-7	D-box binding PAR bZIP transcription factor	Homo sapiens	108-130
17038311-12	2006	Subsequently, we identified and mutated to alanine four proline-rich motifs in the PTH1R distal C terminus, which resulted in loss of both c-Src and arrestin co-precipitation and significantly decreased ERK1/2 activation.	Proline	56-63	parathyroid hormone 1 receptor	Homo sapiens	83-88
17038311-12	2006	Subsequently, we identified and mutated to alanine four proline-rich motifs in the PTH1R distal C terminus, which resulted in loss of both c-Src and arrestin co-precipitation and significantly decreased ERK1/2 activation.	Proline	56-63	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	139-144
17038311-12	2006	Subsequently, we identified and mutated to alanine four proline-rich motifs in the PTH1R distal C terminus, which resulted in loss of both c-Src and arrestin co-precipitation and significantly decreased ERK1/2 activation.	Proline	56-63	mitogen-activated protein kinase 3	Homo sapiens	203-209
17038311-13	2006	These data delineate the multiple PTH1R structural determinants for ERK1/2 activation and newly identify a unique mechanism involving proline-rich motifs in the receptor C terminus for reciprocal scaffolding of c-Src and beta-arrestin2 with a class II G-protein-coupled receptor.	Proline	134-141	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	211-216
17038311-13	2006	These data delineate the multiple PTH1R structural determinants for ERK1/2 activation and newly identify a unique mechanism involving proline-rich motifs in the receptor C terminus for reciprocal scaffolding of c-Src and beta-arrestin2 with a class II G-protein-coupled receptor.	Proline	134-141	arrestin beta 2	Homo sapiens	221-235
17178850-3	2006	In this report, we show that WWOX, via its first WW domain, specifically associates with the proline-rich motif of c-Jun proto-oncogene.	Proline	93-100	WW domain containing oxidoreductase	Homo sapiens	29-33
17057225-1	2006	Proline- and acid-rich (PAR) basic region leucine zipper (bZIP) proteins thyrotroph embryonic factor (TEF), D-site-binding protein (DBP), and hepatic leukemia factor have been involved in neurotransmitter homeostasis and amino acid metabolism.	Proline	0-7	D-box binding PAR bZIP transcription factor	Homo sapiens	132-135
17057225-1	2006	Proline- and acid-rich (PAR) basic region leucine zipper (bZIP) proteins thyrotroph embryonic factor (TEF), D-site-binding protein (DBP), and hepatic leukemia factor have been involved in neurotransmitter homeostasis and amino acid metabolism.	Proline	0-7	HLF transcription factor, PAR bZIP family member	Homo sapiens	142-165
17040910-1	2006	DPP8 belongs to the family of prolyl dipeptidases, which are capable of cleaving the peptide bond after a penultimate proline residue.	Proline	118-125	dipeptidyl peptidase 8	Homo sapiens	0-4
17147829-7	2006	Compared to ENV proteins of other MuLV-A"s (4070A, 1504A and 10A-1), the gp70 protein of MuLV-1313 exhibits differences in its signal peptides and the proline-rich hinge regions.	Proline	151-158	embigin	Mus musculus	73-77
17015442-8	2006	We found that Sit4 actively brought about Gln3-Myc(13) dephosphorylation in both good (glutamine or ammonia) and poor (proline) nitrogen sources.	Proline	119-126	type 2A-related serine/threonine-protein phosphatase SIT4	Saccharomyces cerevisiae S288C	14-18
17015442-8	2006	We found that Sit4 actively brought about Gln3-Myc(13) dephosphorylation in both good (glutamine or ammonia) and poor (proline) nitrogen sources.	Proline	119-126	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	42-46
17178850-3	2006	In this report, we show that WWOX, via its first WW domain, specifically associates with the proline-rich motif of c-Jun proto-oncogene.	Proline	93-100	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	115-120
17172857-5	2006	At normoxia HIF-1alpha is hydroxylated at specific proline residues by a recently identified family of prolyl hydroxylases.	Proline	51-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-22
17224082-5	2006	However, mammalian MIXL1 contains a unique proline-rich domain (PRD) with a potential to interact with signal transducing Src homolgy 3 (SH3) domains.	Proline	43-50	Mix paired-like homeobox	Homo sapiens	19-24
17081196-2	2006	Prolidase is a Mn(2+)-dependent dipeptidase that cleaves imidodipeptides containing C-terminal proline or hydroxyproline.	Proline	95-102	peptidase D	Homo sapiens	0-9
16985102-12	2006	The increase in catalytic efficiency observed for Pro360 in human FMO3 was also observed when the His of FMO1 was replaced by Pro at loci 360.	Proline	50-53	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	66-70
16985102-12	2006	The increase in catalytic efficiency observed for Pro360 in human FMO3 was also observed when the His of FMO1 was replaced by Pro at loci 360.	Proline	50-53	flavin containing dimethylaniline monoxygenase 1	Homo sapiens	105-109
17130464-0	2006	Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.	Proline	40-47	insulin	Homo sapiens	0-7
17130464-0	2006	Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.	Proline	40-47	AKT serine/threonine kinase 1	Rattus norvegicus	53-56
17130464-0	2006	Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.	Proline	40-47	AKT1 substrate 1	Rattus norvegicus	67-73
17130464-0	2006	Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.	Proline	40-47	insulin	Homo sapiens	89-96
17059562-4	2006	This study shows that HRD1 was expressed in substantia nigra pars compacta (SNC) dopaminergic neurons and interacted with Pael-R through the HRD1 proline-rich region, promoting the ubiquitylation and degradation of Pael-R.	Proline	146-153	synoviolin 1	Homo sapiens	22-26
17094785-2	2006	We previously showed that the primary interaction between Src and Cbl is mediated by the Src homology domain 3 (SH3) of Src binding to proline-rich sequences of Cbl.	Proline	135-142	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	58-61
17094785-2	2006	We previously showed that the primary interaction between Src and Cbl is mediated by the Src homology domain 3 (SH3) of Src binding to proline-rich sequences of Cbl.	Proline	135-142	Cbl proto-oncogene	Homo sapiens	66-69
17094785-2	2006	We previously showed that the primary interaction between Src and Cbl is mediated by the Src homology domain 3 (SH3) of Src binding to proline-rich sequences of Cbl.	Proline	135-142	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	89-92
17094785-2	2006	We previously showed that the primary interaction between Src and Cbl is mediated by the Src homology domain 3 (SH3) of Src binding to proline-rich sequences of Cbl.	Proline	135-142	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	89-92
17094785-2	2006	We previously showed that the primary interaction between Src and Cbl is mediated by the Src homology domain 3 (SH3) of Src binding to proline-rich sequences of Cbl.	Proline	135-142	Cbl proto-oncogene	Homo sapiens	161-164
17094785-4	2006	Mutating prolines 543-548 reduced Src binding to the Cbl 479-636 fragment significantly more than mutating the prolines in the PPVPPR(494-499) motif, which was previously reported to bind Src SH3.	Proline	9-17	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	34-37
17094785-4	2006	Mutating prolines 543-548 reduced Src binding to the Cbl 479-636 fragment significantly more than mutating the prolines in the PPVPPR(494-499) motif, which was previously reported to bind Src SH3.	Proline	9-17	Cbl proto-oncogene	Homo sapiens	53-56
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Proline	13-21	Cbl proto-oncogene	Homo sapiens	9-12
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Proline	13-21	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	64-67
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Proline	13-21	Cbl proto-oncogene	Homo sapiens	79-82
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Proline	13-21	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	84-87
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Proline	13-21	Cbl proto-oncogene	Homo sapiens	79-82
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Proline	13-21	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	84-87
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Proline	13-21	Cbl proto-oncogene	Homo sapiens	79-82
16987806-3	2006	VASP was initially characterized as a proline-rich substrate of protein kinases A and G in human platelets and later shown to be a scaffold protein, regulating both signal transduction pathways and the actin filament system.	Proline	38-45	vasodilator stimulated phosphoprotein	Homo sapiens	0-4
17105764-6	2006	Gene expression profiling of Arnt-null mouse epidermis revealed upregulation of genes of the epidermal differentiation complex on mouse chromosome 3, including S100a genes (S100a8, S100a9, S100a10) and genes coding for small proline-rich proteins (Sprr1a, Sprr2i, Sprr2j, Sprrl1).	Proline	225-232	aryl hydrocarbon receptor nuclear translocator	Mus musculus	29-33
17130521-4	2006	Helical periodicity analysis of the mutation-induced perturbations in voltage activation and deactivation kinetics of KCNQ1-KCNE1 complexes defined that the KCNE1 C terminus is alpha-helical when split in half at a conserved proline residue.	Proline	225-232	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	118-123
17130521-4	2006	Helical periodicity analysis of the mutation-induced perturbations in voltage activation and deactivation kinetics of KCNQ1-KCNE1 complexes defined that the KCNE1 C terminus is alpha-helical when split in half at a conserved proline residue.	Proline	225-232	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	124-129
17130521-4	2006	Helical periodicity analysis of the mutation-induced perturbations in voltage activation and deactivation kinetics of KCNQ1-KCNE1 complexes defined that the KCNE1 C terminus is alpha-helical when split in half at a conserved proline residue.	Proline	225-232	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	157-162
17059562-4	2006	This study shows that HRD1 was expressed in substantia nigra pars compacta (SNC) dopaminergic neurons and interacted with Pael-R through the HRD1 proline-rich region, promoting the ubiquitylation and degradation of Pael-R.	Proline	146-153	G protein-coupled receptor 37	Homo sapiens	122-128
17059562-4	2006	This study shows that HRD1 was expressed in substantia nigra pars compacta (SNC) dopaminergic neurons and interacted with Pael-R through the HRD1 proline-rich region, promoting the ubiquitylation and degradation of Pael-R.	Proline	146-153	synoviolin 1	Homo sapiens	141-145
17059562-4	2006	This study shows that HRD1 was expressed in substantia nigra pars compacta (SNC) dopaminergic neurons and interacted with Pael-R through the HRD1 proline-rich region, promoting the ubiquitylation and degradation of Pael-R.	Proline	146-153	G protein-coupled receptor 37	Homo sapiens	215-221
17161366-0	2006	Structural insights into the specific binding of huntingtin proline-rich region with the SH3 and WW domains.	Proline	60-67	huntingtin	Homo sapiens	49-59
17113976-3	2006	Bovine adrenal glomerulosa (BAG) cells express receptors for endothelin-1 (ET-1) and their stimulation caused phosphorylation of Src (at Tyr416), proline-rich tyrosine kinase (Pyk2 at Tyr402), extracellularly regulated signal kinases (ERK1/2), and their dependent proteins, p90 ribosomal S6 kinase (RSK-1) and CREB.	Proline	146-153	endothelin 1	Bos taurus	61-73
17113976-3	2006	Bovine adrenal glomerulosa (BAG) cells express receptors for endothelin-1 (ET-1) and their stimulation caused phosphorylation of Src (at Tyr416), proline-rich tyrosine kinase (Pyk2 at Tyr402), extracellularly regulated signal kinases (ERK1/2), and their dependent proteins, p90 ribosomal S6 kinase (RSK-1) and CREB.	Proline	146-153	endothelin 1	Bos taurus	75-79
17156730-4	2006	3BP2 displays the typical modular organization of an adapter protein with an amino-terminal PH domain, a central proline rich region and a carboxyl-terminal SH2 domain.	Proline	113-120	SH3 domain binding protein 2	Homo sapiens	0-4
17030600-8	2006	Finally, the proline-rich C-terminal sites mediate strong interactions with DCrk, as expected.	Proline	13-20	Crk oncogene	Drosophila melanogaster	76-80
16987982-7	2006	In addition, Vpx interacts with the cellular tyrosine kinase Fyn through its C-terminal proline-rich motif.	Proline	88-95	vpx protein	Simian immunodeficiency virus	13-16
16987982-7	2006	In addition, Vpx interacts with the cellular tyrosine kinase Fyn through its C-terminal proline-rich motif.	Proline	88-95	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	61-64
17050774-4	2006	Using mitotic phosphoprotein monoclonal-2 (MPM-2) antibody in this study, we observed that several mouse sperm proteins in the range of 70-250 kDa underwent increased serine/threonine-proline phosphorylation during capacitation.	Proline	184-191	forkhead box M1	Mus musculus	6-41
17050774-4	2006	Using mitotic phosphoprotein monoclonal-2 (MPM-2) antibody in this study, we observed that several mouse sperm proteins in the range of 70-250 kDa underwent increased serine/threonine-proline phosphorylation during capacitation.	Proline	184-191	forkhead box M1	Mus musculus	43-48
17161366-2	2006	We report the specific interactions of Htt proline-rich region (PRR) with the SH3GL3-SH3 domain and HYPA-WW1-2 domain pair by NMR.	Proline	43-50	huntingtin	Homo sapiens	39-42
17114296-8	2006	Hypoxia increases both the expression and activity of IKKbeta, and site-directed mutagenesis of the proline residue (P191A) of the putative IKKbeta hydroxylation site results in a loss of hypoxic inducibility.	Proline	100-107	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	54-61
17114296-8	2006	Hypoxia increases both the expression and activity of IKKbeta, and site-directed mutagenesis of the proline residue (P191A) of the putative IKKbeta hydroxylation site results in a loss of hypoxic inducibility.	Proline	100-107	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	140-147
17101698-5	2006	Ror2-mediated cell migration requires the extracellular cysteine-rich domain (CRD), which is the binding site for Wnt5a, and the cytoplasmic proline-rich domain (PRD) of Ror2.	Proline	141-148	receptor tyrosine kinase like orphan receptor 2	Homo sapiens	0-4
16954223-8	2006	We demonstrate that C-PIX, containing proline-rich, GBD, and leucine zipper domains can interact with Rac1 via the GBD in vitro and in vivo and also mediated bFGF-stimulated Rac1 activation, as determined by a modified GEF assay and fluorescence resonance energy transfer analysis.	Proline	38-45	Rac family small GTPase 1	Homo sapiens	102-106
16973603-4	2006	Strikingly, deletion of Hsp104 increases the size of inclusions formed by expanded poly(Q) lacking the proline-rich region and abolishes toxicity.	Proline	103-110	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	24-30
17123452-6	2006	When evaluated by several pathway and biological process analysis programs, these proteins are demonstrated to be involved with a high degree of confidence (p values &lt; 2.0 E-05) in glycolysis, propanoate metabolism, pyruvate metabolism, urea cycle and arginine/proline metabolism, as well as in the non-metabolic p53 and FAS pathways.	Proline	264-271	tumor protein p53	Homo sapiens	316-319
17101698-5	2006	Ror2-mediated cell migration requires the extracellular cysteine-rich domain (CRD), which is the binding site for Wnt5a, and the cytoplasmic proline-rich domain (PRD) of Ror2.	Proline	141-148	receptor tyrosine kinase like orphan receptor 2	Homo sapiens	170-174
17045926-7	2006	Since caspase-3 cleaves PKCdelta between proline and aspartate residues at the cleavage site 324DIPD327 to activate the kinase, we developed an irreversible and competitive peptide inhibitor, Z-Asp(OMe)-Ile-Pro-Asp(OMe)-FMK (z-DIPD-fmk), to mimic the caspase-3 cleavage site of PKCdelta and tested its efficacy against oxidative stress-induced cell death in PD models.	Proline	41-48	caspase 3	Mus musculus	6-15
17045926-7	2006	Since caspase-3 cleaves PKCdelta between proline and aspartate residues at the cleavage site 324DIPD327 to activate the kinase, we developed an irreversible and competitive peptide inhibitor, Z-Asp(OMe)-Ile-Pro-Asp(OMe)-FMK (z-DIPD-fmk), to mimic the caspase-3 cleavage site of PKCdelta and tested its efficacy against oxidative stress-induced cell death in PD models.	Proline	41-48	protein kinase C, delta	Mus musculus	24-32
16966331-4	2006	In cell-free systems, Alix directly interacts with F-actin at both the N-terminal Bro1 domain and the C-terminal proline-rich domain.	Proline	113-120	programmed cell death 6 interacting protein	Homo sapiens	22-26
16968695-6	2006	In this work we use a combination of mass spectrometry and systematic mutagenesis to identify seven Ser/Thr-Pro motifs within Pah1p that are phosphorylated in vivo.	Proline	108-111	phosphatidate phosphatase PAH1	Saccharomyces cerevisiae S288C	126-131
17056340-1	2006	This study aimed to evaluate how large the variation between measurements of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) can be in patients with clinically stable heart failure (HF).	Proline	88-91	natriuretic peptide B	Homo sapiens	127-130
16973606-4	2006	The site of filamin interaction on PTP-PEST was mapped to the fourth proline-rich region (Pro4).	Proline	69-76	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	35-43
16891373-2	2006	Here we analyze three usages of flexible linkers: 1), intramolecular binding of proline-rich peptides (PRPs) to SH3 domains for kinase regulation; 2), intramolecular binding of PRP for increasing the folding stability of SH3 domains; and 3), covalent linking of PRPs and other ligands for high-affinity bivalent binding.	Proline	80-87	caspase recruitment domain family member 14	Homo sapiens	103-106
16828917-1	2006	Mitochondrial respiratory function in a patient with maternally inherited type 2 diabetes mellitus and hypertrophic cardiomyopathy associated with heteroplasmic mitochondrial DNA (mtDNA) C3310T mutation, which replaces the second amino acid of NADH dehydrogenase 1 (ND1) from a hydrophobic Proline to a hydrophilic Serine, was investigated.	Proline	290-297	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	244-264
16978607-4	2006	This effect is (i) concentration-dependent, (ii) reaches the order of magnitude of that induced by formyl-methyonyl-leucyl-proline (fMLP) or CC chemokine ligand 2 (CCL2)/monocyte chemotactic protein (MCP)-1, (iii) inhibited by anti-Nef monoclonal antibodies as well as by heating, and (iv) depends on a concentration gradient of Nef.	Proline	122-130	formyl peptide receptor 1	Homo sapiens	132-136
16919454-2	2006	The study was performed on previously developed prolyl oligopeptidase inhibitors with proline mimetics at the P2 position.	Proline	86-93	prolyl endopeptidase	Homo sapiens	48-69
17077298-6	2006	According to Ussing chamber experiments, electrogenic transport of phenylalanine, cysteine, glutamine, proline, leucine, and tryptophan was significantly smaller in jejunum of pdk1(hm) mice than in pdk1(wt) mice.	Proline	103-110	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	176-184
17077298-6	2006	According to Ussing chamber experiments, electrogenic transport of phenylalanine, cysteine, glutamine, proline, leucine, and tryptophan was significantly smaller in jejunum of pdk1(hm) mice than in pdk1(wt) mice.	Proline	103-110	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	176-180
17077298-7	2006	Similarly, electrogenic transport of phenylalanine, glutamine, and proline was significantly decreased in isolated perfused proximal tubules of pdk1(hm) mice.	Proline	67-74	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	144-152
16941565-1	2006	The cytoplasmic region of the CD2 receptor of lymphocytes contains proline-rich motifs, which are involved in T cell activation and interleukin-2 production.	Proline	67-74	CD2 molecule	Homo sapiens	30-33
16972078-1	2006	The human fatty acid amide hydrolase (FAAH) missense mutation c.385 C--&gt;A, which results in conversion of a conserved proline residue to threonine (P129T), has been associated with street drug use and problem drug abuse.	Proline	121-128	fatty acid amide hydrolase	Homo sapiens	10-36
16972078-1	2006	The human fatty acid amide hydrolase (FAAH) missense mutation c.385 C--&gt;A, which results in conversion of a conserved proline residue to threonine (P129T), has been associated with street drug use and problem drug abuse.	Proline	121-128	fatty acid amide hydrolase	Homo sapiens	38-42
16941565-1	2006	The cytoplasmic region of the CD2 receptor of lymphocytes contains proline-rich motifs, which are involved in T cell activation and interleukin-2 production.	Proline	67-74	interleukin 2	Homo sapiens	132-145
16941565-3	2006	CD2BP2 contains a GYF (glycine-tyrosine-phenylalanine) domain that confers binding to these proline-rich sequences.	Proline	92-99	CD2 cytoplasmic tail binding protein 2	Homo sapiens	0-6
16887929-3	2006	We found that KPI-2 is strictly a Ser/Thr kinase that reacts with Ser either preceded by or followed by Pro residues but unlike other Pro-directed kinases does not strictly require an adjacent Pro residue.	Proline	104-107	lemur tyrosine kinase 2	Homo sapiens	14-19
17228098-8	2006	Age-dependent up-regulation was the most pronounced in the case of following genes: similar to MAD2L1 binding protein, similar to thymocyte protein thy28 isoform 1, similar to type I inositol-1,4,5-triphosphate 5-phosphatase, similar to nucleoside diphosphate kinase 6, proline rich 14, similar to transcription factor E2-alpha and phospholipase C gamma 1.	Proline	270-277	MAD2L1 binding protein	Bos taurus	95-117
17228098-8	2006	Age-dependent up-regulation was the most pronounced in the case of following genes: similar to MAD2L1 binding protein, similar to thymocyte protein thy28 isoform 1, similar to type I inositol-1,4,5-triphosphate 5-phosphatase, similar to nucleoside diphosphate kinase 6, proline rich 14, similar to transcription factor E2-alpha and phospholipase C gamma 1.	Proline	270-277	NME/NM23 nucleoside diphosphate kinase 6	Bos taurus	237-268
17228098-8	2006	Age-dependent up-regulation was the most pronounced in the case of following genes: similar to MAD2L1 binding protein, similar to thymocyte protein thy28 isoform 1, similar to type I inositol-1,4,5-triphosphate 5-phosphatase, similar to nucleoside diphosphate kinase 6, proline rich 14, similar to transcription factor E2-alpha and phospholipase C gamma 1.	Proline	270-277	phospholipase C gamma 1	Bos taurus	332-355
16825292-8	2006	Deletion studies in transfected HeLa cells indicated that proline-rich regions located at either side of the Alx3 homeodomain work together with E47/Pan1, and that this requires the integrity of the amino-terminal activation domain to transactivate.	Proline	58-65	ALX homeobox 3	Homo sapiens	109-113
16825292-8	2006	Deletion studies in transfected HeLa cells indicated that proline-rich regions located at either side of the Alx3 homeodomain work together with E47/Pan1, and that this requires the integrity of the amino-terminal activation domain to transactivate.	Proline	58-65	transcription factor 3	Homo sapiens	145-148
16825292-8	2006	Deletion studies in transfected HeLa cells indicated that proline-rich regions located at either side of the Alx3 homeodomain work together with E47/Pan1, and that this requires the integrity of the amino-terminal activation domain to transactivate.	Proline	58-65	NLR family pyrin domain containing 2	Homo sapiens	149-153
21176462-1	2006	BACKGROUND: The conformation of a subset of phosphorylated serines or threonines preceding proline motifs is regulated by the prolyl isomerase Pin1.	Proline	91-98	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	143-147
17098192-4	2006	The analysis of diverse sequences, including those of elastin, amyloids, spider silks, wheat gluten, and insect resilin, reveals a threshold in proline and glycine composition above which amyloid formation is impeded and elastomeric properties become apparent.	Proline	144-151	elastin	Homo sapiens	54-61
16895900-6	2006	Upon deletion of 54 residues at the C terminus of p22phox (amino acids 142-195), maturation and cell surface expression of gp91phox was still preserved, although NADPH oxidase activity was absent, as expected, due to removal of a proline-rich domain between amino acids 151-160 that is required for recruitment of p47phox.	Proline	230-237	cytochrome b-245 alpha chain	Homo sapiens	50-57
16721787-3	2006	Among 856 colorectal adenoma cases and 1,184 controls, we observed a modest association with p53 Arg72Pro genotype (multivariate odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.04-1.50 for Arg/Pro and Pro/Pro vs. Arg/Arg).	Proline	102-105	tumor protein p53	Homo sapiens	93-96
16721787-3	2006	Among 856 colorectal adenoma cases and 1,184 controls, we observed a modest association with p53 Arg72Pro genotype (multivariate odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.04-1.50 for Arg/Pro and Pro/Pro vs. Arg/Arg).	Proline	202-205	tumor protein p53	Homo sapiens	93-96
16721787-3	2006	Among 856 colorectal adenoma cases and 1,184 controls, we observed a modest association with p53 Arg72Pro genotype (multivariate odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.04-1.50 for Arg/Pro and Pro/Pro vs. Arg/Arg).	Proline	202-205	tumor protein p53	Homo sapiens	93-96
16904100-6	2006	Fndc3a, which is expressed in several tissues including testis, encodes a novel protein composed of a proline-rich amino-terminus, nine fibronectin type-III domains, and a hydrophobic carboxy-terminus.	Proline	102-109	fibronectin type III domain containing 3A	Mus musculus	0-6
16848763-3	2006	Further experiments showed that DAZAP1 was phosphorylated stoichiometrically in vitro by ERK2 (extracellular-signal-regulated protein kinase 2) at two Thr-Pro sequences (Thr269 and Thr315), and that both sites became phosphorylated in HEK-293 (human embryonic kidney 293) cells in response to PMA or EGF (epidermal growth factor), or RAW 264.7 macrophages in response to LPS.	Proline	155-158	DAZ associated protein 1	Homo sapiens	32-38
16848763-3	2006	Further experiments showed that DAZAP1 was phosphorylated stoichiometrically in vitro by ERK2 (extracellular-signal-regulated protein kinase 2) at two Thr-Pro sequences (Thr269 and Thr315), and that both sites became phosphorylated in HEK-293 (human embryonic kidney 293) cells in response to PMA or EGF (epidermal growth factor), or RAW 264.7 macrophages in response to LPS.	Proline	155-158	mitogen-activated protein kinase 1	Homo sapiens	95-142
16879874-6	2006	This polymorphism changes the first codon position of amino acid 183 and results in a Pro/Ser substitution in the N-terminal region of domain 3 of the CD4 protein.	Proline	86-89	T-cell surface glycoprotein CD4	Ovis aries	151-154
16893902-3	2006	Spry2 is considerably more inhibitory than Spry1 or Spry4, and this correlates with the binding to Grb2 via a C-terminal proline-rich sequence that is found exclusively on Spry2.	Proline	121-128	sprouty RTK signaling antagonist 2	Homo sapiens	0-5
17038183-5	2006	Mutagenesis of FIV CA showed that an amino acid that is in a homologous position to the proline at amino acid 90 of HIV-1 CA is essential for FIV interactions with CypA.	Proline	88-95	peptidylprolyl isomerase A	Homo sapiens	164-168
16935423-3	2006	In this study, we found that recombinant DJ-1 expressed in and purified from E. coli was specifically cleaved between glycine and proline at amino acid numbers 157 and 158, respectively, by treatment of DJ-1 with H2O2.	Proline	130-137	Parkinsonism associated deglycase	Homo sapiens	41-45
16935423-3	2006	In this study, we found that recombinant DJ-1 expressed in and purified from E. coli was specifically cleaved between glycine and proline at amino acid numbers 157 and 158, respectively, by treatment of DJ-1 with H2O2.	Proline	130-137	Parkinsonism associated deglycase	Homo sapiens	203-207
16879850-3	2006	RFHVMn LANA is structurally analogous to KSHV ORF73 LANA and contains an N-terminal serine-proline-rich region, a large internal glutamic acidic-rich repeat region and a conserved C-terminal domain.	Proline	91-98	LANA	Human gammaherpesvirus 8	7-11
16893902-3	2006	Spry2 is considerably more inhibitory than Spry1 or Spry4, and this correlates with the binding to Grb2 via a C-terminal proline-rich sequence that is found exclusively on Spry2.	Proline	121-128	growth factor receptor bound protein 2	Homo sapiens	99-103
16893902-3	2006	Spry2 is considerably more inhibitory than Spry1 or Spry4, and this correlates with the binding to Grb2 via a C-terminal proline-rich sequence that is found exclusively on Spry2.	Proline	121-128	sprouty RTK signaling antagonist 2	Homo sapiens	172-177
17002312-2	2006	The peptidyl prolyl cis/trans isomerase Pin1 specifically catalyzes the conformational transition of phosphorylated Ser/Thr-Pro motifs.	Proline	124-127	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	40-44
17003361-0	2006	Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetes.	Proline	10-17	pancreatic and duodenal homeobox 1	Homo sapiens	35-60
17002676-8	2006	Non-heme ferrous iron containing hydroxylases use dioxygen and 2-oxoglutarate to specifically target proline and an asparagine residue in HIF-1alpha.	Proline	101-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-148
16787391-9	2006	The Amtn protein is enriched in proline, leucine, glutamine and threonine (52% of total) and contains a perfectly conserved protein kinase CK2 phosphorylation site.	Proline	32-39	amelotin	Rattus norvegicus	4-8
17003361-0	2006	Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetes.	Proline	10-17	pancreatic and duodenal homeobox 1	Homo sapiens	62-66
17003361-2	2006	We identified an inframe insertion of a proline in the insulin promoter factor 1 (IPF1) gene (InsCCG243), which was relatively common (minor allele frequency approximately 0.08) in African Americans and showed a trend to association with type 2 diabetes in preliminary studies.	Proline	40-47	pancreatic and duodenal homeobox 1	Homo sapiens	55-80
17003361-2	2006	We identified an inframe insertion of a proline in the insulin promoter factor 1 (IPF1) gene (InsCCG243), which was relatively common (minor allele frequency approximately 0.08) in African Americans and showed a trend to association with type 2 diabetes in preliminary studies.	Proline	40-47	pancreatic and duodenal homeobox 1	Homo sapiens	82-86
16958854-0	2006	Functional effects of intramembranous proline substitutions in the staphylococcal multidrug transporter QacA.	Proline	38-45	QacA	Staphylococcus aureus	104-108
16958854-2	2006	QacA contains 10 proline residues predicted to be within transmembrane regions, several of which are conserved in related export proteins.	Proline	17-24	QacA	Staphylococcus aureus	0-4
16958854-4	2006	The importance of these 10 intramembranous proline residues for QacA-mediated transport function was determined by examining the functional effect of substituting these residues with glycine, alanine or serine.	Proline	43-50	QacA	Staphylococcus aureus	64-68
16958854-5	2006	Several proline-substituted QacA mutants failed to confer high-level resistance to selected QacA substrates.	Proline	8-15	QacA	Staphylococcus aureus	28-32
16972175-21	2006	Analysis of the FH gene revealed the maternally derived c.1029_1031delAGT mutation, resulting in Val deletion and substitution of Gln by His, and paternally derived c.976C &gt; T mutation, resulting in substitution of Pro by Ser.	Proline	218-221	fumarate hydratase	Homo sapiens	16-18
16935471-8	2006	RESULTS: VC-IP released Vitamin C in physiological conditions and worked as pro-Vitamin C.	Proline	76-79	phospholipid phosphatase 3	Homo sapiens	9-14
16930317-2	2006	Proline accumulation has been shown to induce tolerance to salt stress, and transgenic plants over-expressing Delta(1)-pyrroline-5-carboxylate synthetase (P5CS), which accumulates high levels of proline, display enhanced osmotolerance.	Proline	0-7	delta-1-pyrroline-5-carboxylate synthase	Medicago truncatula	155-159
17005671-3	2006	The Lck binding domain (LBD) of Tip comprises two interaction motifs, a proline-rich SH3 domain-binding sequence (SH3B) and a region with homology to the C terminus of Src family kinase domains (CSKH).	Proline	72-79	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
17005671-3	2006	The Lck binding domain (LBD) of Tip comprises two interaction motifs, a proline-rich SH3 domain-binding sequence (SH3B) and a region with homology to the C terminus of Src family kinase domains (CSKH).	Proline	72-79	TOR signaling pathway regulator	Homo sapiens	32-35
16964264-0	2006	iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.	Proline	31-38	protein phosphatase 1 regulatory subunit 13 like	Homo sapiens	0-5
16964264-0	2006	iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.	Proline	31-38	tumor protein p53	Homo sapiens	27-30
16964264-2	2006	We show here that, in addition to the DNA-binding domain, the ASPP family members also bind to the proline-rich region of p53, which contains the most common p53 polymorphism at codon 72.	Proline	99-106	tumor protein p53	Homo sapiens	122-125
16964264-2	2006	We show here that, in addition to the DNA-binding domain, the ASPP family members also bind to the proline-rich region of p53, which contains the most common p53 polymorphism at codon 72.	Proline	99-106	tumor protein p53	Homo sapiens	158-161
17080720-7	2006	Genetic studies disclosed the Pro to Leu point mutation at codon 102 with a 102 Leu-129 Met in the PrP gene.	Proline	30-33	prion protein	Homo sapiens	99-102
16930317-2	2006	Proline accumulation has been shown to induce tolerance to salt stress, and transgenic plants over-expressing Delta(1)-pyrroline-5-carboxylate synthetase (P5CS), which accumulates high levels of proline, display enhanced osmotolerance.	Proline	195-202	delta-1-pyrroline-5-carboxylate synthase	Medicago truncatula	110-153
16930317-2	2006	Proline accumulation has been shown to induce tolerance to salt stress, and transgenic plants over-expressing Delta(1)-pyrroline-5-carboxylate synthetase (P5CS), which accumulates high levels of proline, display enhanced osmotolerance.	Proline	195-202	delta-1-pyrroline-5-carboxylate synthase	Medicago truncatula	155-159
16930317-3	2006	Here, we transformed the model legume Medicago truncatula with the P5CS gene from Vigna aconitifolia, and nodule activity was evaluated under osmotic stress in transgenic plants that showed high proline accumulation levels.	Proline	195-202	delta-1-pyrroline-5-carboxylate synthase	Medicago truncatula	67-71
16895919-4	2006	A proline-rich motif of CFBP is recognized by one of the three Src-homology 3 domains of CIN85/CD2AP, and the affinity of the interaction is regulated by the tyrosine phosphorylation of CFBP.	Proline	2-9	multivesicular body subunit 12A	Homo sapiens	24-28
17172050-5	2006	Proline content and SOD activity were increased inductively in rd29A:DREB1A plants than in 35S:DREB1A plants under stress conditions.	Proline	0-7	dehydration response element B1A	Arabidopsis thaliana	69-75
17172050-5	2006	Proline content and SOD activity were increased inductively in rd29A:DREB1A plants than in 35S:DREB1A plants under stress conditions.	Proline	0-7	dehydration response element B1A	Arabidopsis thaliana	95-101
16527444-2	2006	We found that SNL glycoprotein consists of carbohydrate content (69.74%) and protein content (30.26%), which contains more than 50% hydrophobic amino acids such as glycine and proline.	Proline	176-183	fascin actin-bundling protein 1	Homo sapiens	14-17
17008721-1	2006	The Tip protein from Herpesvirus saimiri interacts with the SH3 domain from the Src-family kinase Lck via a proline-containing sequence termed LBD1.	Proline	108-115	TOR signaling pathway regulator	Homo sapiens	4-7
17008721-1	2006	The Tip protein from Herpesvirus saimiri interacts with the SH3 domain from the Src-family kinase Lck via a proline-containing sequence termed LBD1.	Proline	108-115	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	98-101
16864574-2	2006	In cells using ammonium or glutamine, the GATA transcription factor Gln3 is sequestered in the cytoplasm by Ure2 whereas it enters the nucleus after a shift to a nonpreferred nitrogen source like proline or upon addition of rapamycin, the TOR complex inhibitor.	Proline	196-203	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	68-72
16895919-4	2006	A proline-rich motif of CFBP is recognized by one of the three Src-homology 3 domains of CIN85/CD2AP, and the affinity of the interaction is regulated by the tyrosine phosphorylation of CFBP.	Proline	2-9	SH3 domain containing kinase binding protein 1	Homo sapiens	89-94
16895919-4	2006	A proline-rich motif of CFBP is recognized by one of the three Src-homology 3 domains of CIN85/CD2AP, and the affinity of the interaction is regulated by the tyrosine phosphorylation of CFBP.	Proline	2-9	CD2 associated protein	Homo sapiens	95-100
16895919-4	2006	A proline-rich motif of CFBP is recognized by one of the three Src-homology 3 domains of CIN85/CD2AP, and the affinity of the interaction is regulated by the tyrosine phosphorylation of CFBP.	Proline	2-9	multivesicular body subunit 12A	Homo sapiens	186-190
16982733-3	2006	We have shown that the proline-rich sequence in DOC-2/DAB2 is the key functional domain for this action.	Proline	23-30	DAB adaptor protein 2	Rattus norvegicus	48-53
16857672-0	2006	Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway.	Proline	25-32	SLIT-ROBO Rho GTPase activating protein 1	Homo sapiens	63-69
16857672-8	2006	A longer CC3 peptide (CC3-FL) binds with greater affinity than its shorter counterpart, suggesting that the residues surrounding the proline-rich core are important for protein-peptide interactions.	Proline	133-140	C-C motif chemokine ligand 14	Homo sapiens	9-12
16857672-8	2006	A longer CC3 peptide (CC3-FL) binds with greater affinity than its shorter counterpart, suggesting that the residues surrounding the proline-rich core are important for protein-peptide interactions.	Proline	133-140	C-C motif chemokine ligand 14	Homo sapiens	22-25
16996007-0	2006	Effect of proline rich domain of an RNA-binding protein Sam68 in cell growth process, death and B cell signal transduction.	Proline	10-17	KH RNA binding domain containing, signal transduction associated 1	Gallus gallus	56-61
16996007-9	2006	CONCLUSIONS: The proline rich domain of Sam68 is involved in cell growth control by modulating the function of mRNAs in S phase or earlier and the functions as an adaptor molecule in B cell signal transduction pathways.	Proline	17-24	KH RNA binding domain containing, signal transduction associated 1	Gallus gallus	40-45
16934832-1	2006	Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDh) plays an important role in the metabolic pathway from proline to glutamate.	Proline	109-116	aldehyde dehydrogenase 4 family member A1	Homo sapiens	48-53
16982733-3	2006	We have shown that the proline-rich sequence in DOC-2/DAB2 is the key functional domain for this action.	Proline	23-30	DAB adaptor protein 2	Rattus norvegicus	54-58
16982733-9	2006	Taken together, we conclude that a functional peptide derived from proline-rich domain in DOC-2/DAB2 has growth-inhibitory activity as its native protein, and CPP seems to be an efficient delivery system in prostate cancer cells.	Proline	67-74	DAB adaptor protein 2	Rattus norvegicus	90-95
16982733-9	2006	Taken together, we conclude that a functional peptide derived from proline-rich domain in DOC-2/DAB2 has growth-inhibitory activity as its native protein, and CPP seems to be an efficient delivery system in prostate cancer cells.	Proline	67-74	DAB adaptor protein 2	Rattus norvegicus	96-100
16959570-2	2006	We identify the proline isomerase Fpr4, a member of the FK506 binding protein family in Saccharomyces cerevisiae, as an enzyme which binds the amino-terminal tail of histones H3 and H4 and catalyses the isomerization of H3 proline P30 and P38 in vitro.	Proline	16-23	peptidylprolyl isomerase FPR4	Saccharomyces cerevisiae S288C	34-38
16859681-1	2006	CAIR-1/BAG-3 is a stress and survival protein that has been shown to bind SH3 domain-containing proteins through its proline-rich (PXXP) domain.	Proline	117-124	BAG cochaperone 3	Homo sapiens	0-6
16859681-1	2006	CAIR-1/BAG-3 is a stress and survival protein that has been shown to bind SH3 domain-containing proteins through its proline-rich (PXXP) domain.	Proline	117-124	BAG cochaperone 3	Homo sapiens	7-12
16619034-2	2006	We have shown that POX generated proline-dependent reactive oxygen species (ROS), specifically superoxide radicals, and induced apoptosis through the mitochondrial (intrinsic) pathway.	Proline	33-40	proline dehydrogenase 1	Homo sapiens	19-22
16945100-3	2006	Pin-1, one of the peptidyl-prolyl isomerases (PPIase), catalyzes the isomerization of the peptide bond between pSer/Thr-Pro in proteins, thereby regulating their biological functions which include protein assembly, folding, intracellular transport, intracellular signaling, transcription, cell cycle progression and apoptosis.	Proline	120-123	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-5
16908623-0	2006	A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant.	Proline	37-44	CD28 antigen	Mus musculus	54-58
16908623-3	2006	We have generated a gene-targeted knockin mouse expressing a mutation in the C-terminal proline-rich region of the cytoplasmic tail of CD28.	Proline	88-95	CD28 antigen	Mus musculus	135-139
16622594-3	2006	The amino acid transporter PAT1, expressed in intestine, kidney, brain and other organs, mediates the uptake of proline and derivatives in a pH gradient-dependent manner.	Proline	112-119	solute carrier family 36 member 1	Homo sapiens	27-31
16699824-2	2006	We systematically analyzed the structural requirements for PAT1 substrates by testing 87 amino acids, proline homologs, indoles, and derivatives.	Proline	102-109	solute carrier family 36 member 1	Homo sapiens	59-63
16730327-10	2006	Increase of BAC2 transcript levels later in seedling development is consistent with roles in NO, polyamine or proline metabolism--processes involving arginine, citrulline and/or ornithine.	Proline	110-117	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	12-16
17017874-6	2006	The mucin core protein consists of numerous tandem repeats rich in serine, threonine and proline.	Proline	89-96	LOC100508689	Homo sapiens	4-9
16803897-2	2006	Over-activation of proline-directed kinases, such as cyclin-dependent kinase 5 (Cdk5) and glycogen synthase kinase 3 (GSK3), has been implicated in the aberrant phosphorylation of tau at proline-directed sites.	Proline	19-26	cyclin-dependent kinase 5	Mus musculus	53-78
16803897-2	2006	Over-activation of proline-directed kinases, such as cyclin-dependent kinase 5 (Cdk5) and glycogen synthase kinase 3 (GSK3), has been implicated in the aberrant phosphorylation of tau at proline-directed sites.	Proline	19-26	cyclin-dependent kinase 5	Mus musculus	80-84
16803897-2	2006	Over-activation of proline-directed kinases, such as cyclin-dependent kinase 5 (Cdk5) and glycogen synthase kinase 3 (GSK3), has been implicated in the aberrant phosphorylation of tau at proline-directed sites.	Proline	19-26	glycogen synthase kinase 3 beta	Mus musculus	90-116
16803897-2	2006	Over-activation of proline-directed kinases, such as cyclin-dependent kinase 5 (Cdk5) and glycogen synthase kinase 3 (GSK3), has been implicated in the aberrant phosphorylation of tau at proline-directed sites.	Proline	19-26	glycogen synthase kinase 3 beta	Mus musculus	118-122
16923166-1	2006	The vesicular acetylcholine transporter (VAChT) contains six conserved sequence motifs that are rich in proline and glycine.	Proline	104-111	solute carrier family 18 member A3	Homo sapiens	41-46
17094395-1	2006	BACKGROUND: The oncoprotein E6 binds to and degrades the p53 tumor suppressor protein, with different efficacy depending on the p53 codon 72 (arg/pro) polymorphism.	Proline	20-23	tumor protein p53	Homo sapiens	57-60
17094395-1	2006	BACKGROUND: The oncoprotein E6 binds to and degrades the p53 tumor suppressor protein, with different efficacy depending on the p53 codon 72 (arg/pro) polymorphism.	Proline	20-23	tumor protein p53	Homo sapiens	128-131
16903874-7	2006	Comparison of the cleavage sites suggests that sequences with a Trp, Tyr and/or Pro in the P1" or P2" position, or a basic residue in the P3 position, are preferentially cleaved by PC2 and not by other enzymes present in the secretory pathway.	Proline	80-83	proprotein convertase subtilisin/kexin type 2	Mus musculus	181-184
16600630-1	2006	Pyrroline-5-carboxylate reductase (P5CR) catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)(+).	Proline	108-115	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-33
16841372-1	2006	The phospho-Ser/Thr-Pro specific prolyl-isomerase PIN1 is over-expressed in more than 50% of hepatocellular carcinomas (HCCs).	Proline	20-23	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	50-54
16865248-1	2006	The prolyl isomerase Pin1, which specifically catalyzes conformational changes in certain proline-directed phosphorylation sites, is thought to be a critical catalyst for multiple oncogenic pathways.	Proline	90-97	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	21-25
16945932-6	2006	Under salt stress, stg1 maintains a higher K(+)/Na(+) ratio and accumulates less proline than the wild-type control, suggesting that its salt tolerance mechanisms are mainly involved in the regulation of ion balance.	Proline	81-88	TBP-associated factor II 15	Arabidopsis thaliana	19-23
16837101-2	2006	METHODS: Specific HIF-1alpha polymorphisms were assessed in a series of patients with NSCLC: (a) the C to T transition at nucleotide 1744 (position 2028 according to sequence with accession number , which gives rise to Pro/Ser variation at codon 582), (b) the G to A nucleotide substitution at point 1790 (position 2046 according to sequence with accession number , which gives rise to Ala/Thr variation at codon 588), and (c) the dinucleotide GT repeat polymorphism in intron 13.	Proline	219-222	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
16906159-4	2006	In T cells, the SH2 domain of GRB2 binds phosphorylated tyrosines on the adaptor protein LAT and the GRB2 SH3 domains associate with the proline-rich regions of SOS1 and CBL.	Proline	137-144	growth factor receptor bound protein 2	Homo sapiens	30-34
16906159-4	2006	In T cells, the SH2 domain of GRB2 binds phosphorylated tyrosines on the adaptor protein LAT and the GRB2 SH3 domains associate with the proline-rich regions of SOS1 and CBL.	Proline	137-144	linker for activation of T cells	Homo sapiens	89-92
16906159-4	2006	In T cells, the SH2 domain of GRB2 binds phosphorylated tyrosines on the adaptor protein LAT and the GRB2 SH3 domains associate with the proline-rich regions of SOS1 and CBL.	Proline	137-144	growth factor receptor bound protein 2	Homo sapiens	101-105
16906159-4	2006	In T cells, the SH2 domain of GRB2 binds phosphorylated tyrosines on the adaptor protein LAT and the GRB2 SH3 domains associate with the proline-rich regions of SOS1 and CBL.	Proline	137-144	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	161-165
16906159-4	2006	In T cells, the SH2 domain of GRB2 binds phosphorylated tyrosines on the adaptor protein LAT and the GRB2 SH3 domains associate with the proline-rich regions of SOS1 and CBL.	Proline	137-144	Cbl proto-oncogene	Homo sapiens	170-173
16600630-1	2006	Pyrroline-5-carboxylate reductase (P5CR) catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)(+).	Proline	108-115	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-39
16600630-1	2006	Pyrroline-5-carboxylate reductase (P5CR) catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)(+).	Proline	108-115	pyrroline-5-carboxylate reductase 1	Homo sapiens	74-98
16600630-1	2006	Pyrroline-5-carboxylate reductase (P5CR) catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)(+).	Proline	108-115	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-38
16600630-2	2006	The enzymatic cycle between P5C and proline is very important in many physiological and pathological processes.	Proline	36-43	pyrroline-5-carboxylate reductase 1	Homo sapiens	28-31
16971891-7	2006	Mutation screening in PAX3 identified a 701T > C mutation which converted a highly conserved Leu to Pro.	Proline	100-103	paired box 3	Homo sapiens	22-26
17086290-6	2006	Comparing with the codon frequence of Chinese hamster, the highest frequence of synonymous codons for amino acids in CHO dhfr- cells were the same as Chinese hamster except that of Arg and Pro.	Proline	189-192	dihydrofolate reductase	Cricetulus griseus	121-125
16893648-2	2006	Vinculin is made up of a globular head linked to a tail domain by a short proline-rich sequence, and an intramolecular interaction between the head and tail masks the numerous ligand-binding sites in the protein.	Proline	74-81	vinculin	Homo sapiens	0-8
16885030-4	2006	To understand the molecular mechanism of PTPA activity, Ypa1 was cocrystallized with a proline-containing PPIase peptide substrate.	Proline	87-94	protein phosphatase 2 phosphatase activator	Homo sapiens	41-45
16913724-2	2006	DPP IV has high substrate selectivity for peptides with a proline (or an alanine) at the penultimate amino acid position at the N-terminus but tolerates a wide range of natural amino acids at the amino terminal end.	Proline	58-65	dipeptidyl peptidase 4	Homo sapiens	0-6
16741995-1	2006	QM and QM/MM energy calculations have been carried out on an atomic resolution structure of liganded triosephosphate isomerase (TIM) that has an active site proline (Pro168) in a planar conformation.	Proline	157-164	triosephosphate isomerase 1	Homo sapiens	101-126
16741995-1	2006	QM and QM/MM energy calculations have been carried out on an atomic resolution structure of liganded triosephosphate isomerase (TIM) that has an active site proline (Pro168) in a planar conformation.	Proline	157-164	triosephosphate isomerase 1	Homo sapiens	128-131
16741995-7	2006	Comparison of the proline conformation in different TIM X-ray structures, indicates that in the closed conformation of TIM the proline is planar or nearly planar, while in the open conformation it is down puckered.	Proline	18-25	triosephosphate isomerase 1	Homo sapiens	52-55
16741995-7	2006	Comparison of the proline conformation in different TIM X-ray structures, indicates that in the closed conformation of TIM the proline is planar or nearly planar, while in the open conformation it is down puckered.	Proline	18-25	triosephosphate isomerase 1	Homo sapiens	119-122
16741995-7	2006	Comparison of the proline conformation in different TIM X-ray structures, indicates that in the closed conformation of TIM the proline is planar or nearly planar, while in the open conformation it is down puckered.	Proline	127-134	triosephosphate isomerase 1	Homo sapiens	52-55
16741995-7	2006	Comparison of the proline conformation in different TIM X-ray structures, indicates that in the closed conformation of TIM the proline is planar or nearly planar, while in the open conformation it is down puckered.	Proline	127-134	triosephosphate isomerase 1	Homo sapiens	119-122
16889659-19	2006	Amino acid sequence analysis showed the consensus for the amino-terminal proline-rich motifs is P- [WP]-X-[YF] for motif I (when present) and P-P-[FYL]-[FY] for motif II, and that Vps25 may be ubiquitinated.	Proline	73-80	ESCRT-II subunit protein VPS25	Saccharomyces cerevisiae S288C	180-185
16866507-5	2006	(S)-Proline or (S)-2-pyrrolidinecarboxylic acid has been reported to catalyze the Mannich-type reactions of ketones to afford the syn-products.	Proline	0-11	synemin	Homo sapiens	130-133
16866507-5	2006	(S)-Proline or (S)-2-pyrrolidinecarboxylic acid has been reported to catalyze the Mannich-type reactions of ketones to afford the syn-products.	Proline	15-47	synemin	Homo sapiens	130-133
16885030-4	2006	To understand the molecular mechanism of PTPA activity, Ypa1 was cocrystallized with a proline-containing PPIase peptide substrate.	Proline	87-94	peptidylprolyl isomerase RRD1	Saccharomyces cerevisiae S288C	56-60
16885030-4	2006	To understand the molecular mechanism of PTPA activity, Ypa1 was cocrystallized with a proline-containing PPIase peptide substrate.	Proline	87-94	peptidylprolyl isomerase like 1	Homo sapiens	106-112
16802101-0	2006	Whole genome phage display selects for proline-rich Boi polypeptides against Bem1p.	Proline	39-46	phosphatidylinositol-3-phosphate-binding protein BEM1	Saccharomyces cerevisiae S288C	77-82
16786527-3	2006	RESULTS: Sequencing of the nup62 gene showed a missense mutation causing a change from glutamine to proline (Q391P) in all the patients, producing a substitution from a polar, hydrophilic residue to a nonpolar, neutral residue.	Proline	100-107	nucleoporin 62	Homo sapiens	27-32
16275030-5	2006	Rather, the proline-rich motifs of Gab-2 appear to contribute to the constitutive membrane localisation we observe, independently of tyrosine phosphorylation or the PH domain.	Proline	12-19	growth factor receptor bound protein 2-associated protein 2	Mus musculus	35-40
16631425-6	2006	Whereas insulin raised the proline incorporation and the type II collagen synthesis significantly, physiological doses of estradiol did not show significant effects.	Proline	27-34	insulin	Homo sapiens	8-15
16631425-7	2006	The stimulating effect of insulin on the [(3)H]-proline incorporation or the type II collagen synthesis was significantly suppressed after preincubation of cells with 10(-11) to 10(-9) M estradiol resembling an unfavorable effect for articular cartilage.	Proline	48-55	insulin	Homo sapiens	26-33
16318909-3	2006	It has been noted before that the proline-rich domain within the cytosolic part of FasL is required for its vesicular association.	Proline	34-41	Fas ligand	Homo sapiens	83-87
16780921-5	2006	Mass spectral analysis established that the amino-terminal proline, previously implicated as a catalytic base in the PPT-catalyzed reaction, is the site of covalent modification.	Proline	59-66	macrophage migration inhibitory factor	Homo sapiens	117-120
16935477-6	2006	In addition, a proline rich region found in many SH3 binding proteins was identified in HBX.	Proline	15-22	X protein	Hepatitis B virus	88-91
16820935-3	2006	An association between human cancer risk and a single nucleotide polymorphism (SNP) at codon 50 of the AXIN2 gene, encoding either proline (CCT) or serine (TCT), remains undefined.	Proline	131-138	axin 2	Homo sapiens	103-108
16763507-3	2006	We compared patients with severe sepsis or septic shock and patients with acute HF to unravel the influence of the underlying diagnosis on BNP and N-terminal pro-BNP levels.	Proline	158-161	natriuretic peptide B	Homo sapiens	162-165
16835507-3	2006	We evaluated the linkage of the polymorphic variants (Arg/Pro) on TP53 codon 72 with nasopharyngeal cancer development in a case-control study with 392 individuals from a northern Portuguese population, including 107 patients with nasopharyngeal carcinoma and 285 healthy controls.	Proline	58-61	tumor protein p53	Homo sapiens	66-70
16769050-2	2006	We have shown that a fragment released from the central histidine/proline-rich (His/Pro-rich) domain of HRGP blocks endothelial cell migration in vitro and vascularization and growth of murine fibrosarcoma in vivo.	Proline	66-73	histidine-rich glycoprotein	Mus musculus	104-108
16769050-2	2006	We have shown that a fragment released from the central histidine/proline-rich (His/Pro-rich) domain of HRGP blocks endothelial cell migration in vitro and vascularization and growth of murine fibrosarcoma in vivo.	Proline	84-87	histidine-rich glycoprotein	Mus musculus	104-108
16820935-3	2006	An association between human cancer risk and a single nucleotide polymorphism (SNP) at codon 50 of the AXIN2 gene, encoding either proline (CCT) or serine (TCT), remains undefined.	Proline	131-138	CCT	Homo sapiens	140-143
16849454-5	2006	We further show that the proline-rich intracellular domain of FasL is sufficient to costimulate by enhancing the phosphorylation of Akt, ERK1/2, JNK, and FasL itself, by activating the transcription factors NFAT and AP-1, and by enhancing IFN-gamma production.	Proline	25-32	Fas ligand	Homo sapiens	62-66
16868030-5	2006	The diversity of Alix functions is due to its proline-rich C-terminus, which provides multiple protein-binding sites.	Proline	46-53	programmed cell death 6 interacting protein	Homo sapiens	17-21
16847125-1	2006	The Nef protein is a crucial pathogenicity factor of human immunodeficiency virus type 1 (HIV-1) that contains a proline-rich motif consisting of four conserved prolines: Pro69 (P69), P72, P75 and P78.	Proline	113-120	Nef	Human immunodeficiency virus 1	4-7
16847125-1	2006	The Nef protein is a crucial pathogenicity factor of human immunodeficiency virus type 1 (HIV-1) that contains a proline-rich motif consisting of four conserved prolines: Pro69 (P69), P72, P75 and P78.	Proline	113-120	PC4 and SFRS1 interacting protein 1	Homo sapiens	189-192
16847125-1	2006	The Nef protein is a crucial pathogenicity factor of human immunodeficiency virus type 1 (HIV-1) that contains a proline-rich motif consisting of four conserved prolines: Pro69 (P69), P72, P75 and P78.	Proline	113-120	microspherule protein 1	Homo sapiens	197-200
16849454-5	2006	We further show that the proline-rich intracellular domain of FasL is sufficient to costimulate by enhancing the phosphorylation of Akt, ERK1/2, JNK, and FasL itself, by activating the transcription factors NFAT and AP-1, and by enhancing IFN-gamma production.	Proline	25-32	AKT serine/threonine kinase 1	Homo sapiens	132-135
16849454-5	2006	We further show that the proline-rich intracellular domain of FasL is sufficient to costimulate by enhancing the phosphorylation of Akt, ERK1/2, JNK, and FasL itself, by activating the transcription factors NFAT and AP-1, and by enhancing IFN-gamma production.	Proline	25-32	mitogen-activated protein kinase 3	Homo sapiens	137-143
16849454-5	2006	We further show that the proline-rich intracellular domain of FasL is sufficient to costimulate by enhancing the phosphorylation of Akt, ERK1/2, JNK, and FasL itself, by activating the transcription factors NFAT and AP-1, and by enhancing IFN-gamma production.	Proline	25-32	mitogen-activated protein kinase 8	Homo sapiens	145-148
16849454-5	2006	We further show that the proline-rich intracellular domain of FasL is sufficient to costimulate by enhancing the phosphorylation of Akt, ERK1/2, JNK, and FasL itself, by activating the transcription factors NFAT and AP-1, and by enhancing IFN-gamma production.	Proline	25-32	Fas ligand	Homo sapiens	154-158
16849454-5	2006	We further show that the proline-rich intracellular domain of FasL is sufficient to costimulate by enhancing the phosphorylation of Akt, ERK1/2, JNK, and FasL itself, by activating the transcription factors NFAT and AP-1, and by enhancing IFN-gamma production.	Proline	25-32	interferon gamma	Homo sapiens	239-248
16847925-1	2006	BACKGROUND AND OBJECTIVES: Peptidyl prolyl cis-trans isomerase (Pin1) isomerizes only phosphorylated serine or threonine residues preceding proline in certain proteins and affects the protein function.	Proline	140-147	peptidylprolyl isomerase like 1	Homo sapiens	27-62
16847925-1	2006	BACKGROUND AND OBJECTIVES: Peptidyl prolyl cis-trans isomerase (Pin1) isomerizes only phosphorylated serine or threonine residues preceding proline in certain proteins and affects the protein function.	Proline	140-147	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	64-68
16839418-0	2006	Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7.	Proline	99-106	SH2 domain containing 2A	Mus musculus	31-37
16864769-0	2006	The role of the proline-rich domain of Ssdp1 in the modular architecture of the vertebrate head organizer.	Proline	16-23	single-stranded DNA binding protein 3	Mus musculus	39-44
16864769-4	2006	Embryos derived from the gene-trapped line that encodes a truncated Ssdp1 lacking the proline-rich sequence exhibit a lethal abnormal head-development phenotype, resembling mouse embryos deficient for Lim1, Ssdp1, or Otx2 genes.	Proline	86-93	single-stranded DNA binding protein 3	Mus musculus	68-73
16864769-5	2006	Embryos derived from the second gene-trapped line, in which most of the proline-rich domain of Ssdp1 is retained, did not show abnormalities in head development.	Proline	72-79	single-stranded DNA binding protein 3	Mus musculus	95-100
16864769-6	2006	Our data demonstrate that components of the Ldb1-dependent module can be subdivided further into discrete functional domains and that the proline-rich stretch of Ssdp1 is critical for embryonic head development.	Proline	138-145	LIM domain binding 1	Mus musculus	44-48
16864769-6	2006	Our data demonstrate that components of the Ldb1-dependent module can be subdivided further into discrete functional domains and that the proline-rich stretch of Ssdp1 is critical for embryonic head development.	Proline	138-145	single-stranded DNA binding protein 3	Mus musculus	162-167
16864769-7	2006	Furthermore, phylogenetic comparisons revealed that in Caenorhabditis elegans, a similar proline-rich sequence is absent in Ssdp but present in Ldb1.	Proline	89-96	LIM domain-binding protein 1;LIM interaction domain (LID) domain-containing protein	Caenorhabditis elegans	144-148
16951497-5	2006	RESULTS: The tri-nucleotide (CAG) length polymorphism in the last coding exon of MEF2A in the Chinese was revealed and 4 of the 175 (2.3%) CAD samples containing 4 prolines were due to one proline deletion in MEF2A gene.	Proline	164-171	myocyte enhancer factor 2A	Homo sapiens	81-86
16769036-1	2006	Dipeptidyl peptidase IV (DPP-IV) and seprase belong to a small group of membrane-bound, proline-specific serine proteases, the serine integral membrane proteases (SIMPs).	Proline	88-95	dipeptidyl peptidase 4	Homo sapiens	0-23
16769036-1	2006	Dipeptidyl peptidase IV (DPP-IV) and seprase belong to a small group of membrane-bound, proline-specific serine proteases, the serine integral membrane proteases (SIMPs).	Proline	88-95	dipeptidyl peptidase 4	Homo sapiens	25-31
16769036-1	2006	Dipeptidyl peptidase IV (DPP-IV) and seprase belong to a small group of membrane-bound, proline-specific serine proteases, the serine integral membrane proteases (SIMPs).	Proline	88-95	fibroblast activation protein alpha	Homo sapiens	37-44
16810321-2	2006	The Arabidopsis thaliana proline dehydrogenase (ProDH) is catalysing the first step in proline degradation.	Proline	25-32	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	48-53
16677712-7	2006	l-Proline was added to the sample to a final concentration of 0.1 M to prevent the aggregation of Lp(a) with LDL.	Proline	0-9	lipoprotein(a)	Homo sapiens	98-103
16682408-7	2006	The internal proline/serine/threonine-rich repeat domain (called the RPT domain) of PMEL17 undergoes variable proteolytic cleavage.	Proline	13-20	premelanosome protein	Homo sapiens	84-90
16883531-5	2006	RESULTS: Five members of this family were confirmed to have the C to G transition mutation at nucleotide 1642 site within exon 10 of TR beta gene, which was a missense mutation causing the substitution of Proline to Alanine (P453A); and also to have the C to T transition mutation at nucleotide 1020 within exon 7 of TR beta gene, which was a synonymous mutation that didn"t cause the change of amino acid at this position (F245F).	Proline	205-212	T cell receptor beta locus	Homo sapiens	133-140
16883531-5	2006	RESULTS: Five members of this family were confirmed to have the C to G transition mutation at nucleotide 1642 site within exon 10 of TR beta gene, which was a missense mutation causing the substitution of Proline to Alanine (P453A); and also to have the C to T transition mutation at nucleotide 1020 within exon 7 of TR beta gene, which was a synonymous mutation that didn"t cause the change of amino acid at this position (F245F).	Proline	205-212	T cell receptor beta locus	Homo sapiens	317-324
16675458-0	2006	Up-regulation of the fidelity of human DNA polymerase lambda by its non-enzymatic proline-rich domain.	Proline	82-89	DNA polymerase lambda	Homo sapiens	39-60
16675458-4	2006	The full-length DNA polymerase lambda is comprised of three domains: a C-terminal DNA polymerase beta-like domain, an N-terminal BRCA1 C-terminal domain, and a previously uncharacterized proline-rich domain.	Proline	187-194	DNA polymerase lambda	Homo sapiens	16-37
16675458-6	2006	We further demonstrate that the non-enzymatic proline-rich domain confers the increase in fidelity of DNA polymerase lambda by significantly lowering incorporation rate constants of incorrect nucleotides.	Proline	46-53	DNA polymerase lambda	Homo sapiens	102-123
16839418-0	2006	Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7.	Proline	99-106	SH2 domain containing 2A	Mus musculus	130-136
16818231-5	2006	Furthermore, in the context of Cdc4alpha and cyclin E, mutational data suggest that Pin1 isomerizes a noncanonical proline-proline bond, with the possibility that Cdc4alpha may serve as a cofactor for altering the specificity of Pin1.	Proline	115-122	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	84-88
16627472-9	2006	Mutational analysis shows that the interaction of the two proteins requires both a TRPV4-specific proline-rich domain upstream of the ankyrin repeats of the channel and the carboxyl-terminal Src homology 3 domain of PACSIN 3.	Proline	98-105	transient receptor potential cation channel subfamily V member 4	Homo sapiens	83-88
16627472-9	2006	Mutational analysis shows that the interaction of the two proteins requires both a TRPV4-specific proline-rich domain upstream of the ankyrin repeats of the channel and the carboxyl-terminal Src homology 3 domain of PACSIN 3.	Proline	98-105	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	216-224
16818231-5	2006	Furthermore, in the context of Cdc4alpha and cyclin E, mutational data suggest that Pin1 isomerizes a noncanonical proline-proline bond, with the possibility that Cdc4alpha may serve as a cofactor for altering the specificity of Pin1.	Proline	123-130	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	84-88
16509823-3	2006	In the presence of oxygen, they hydroxylate specific proline residues in HIF-alpha, allowing recognition by pVHL (von Hippel-Lindau protein) and subsequent ubiquitylation and proteasomal destruction.	Proline	53-60	von Hippel-Lindau tumor suppressor	Homo sapiens	108-112
16531028-1	2006	The recently cloned proton-coupled amino acid transporter 1 (PAT1) not only accepts several amino acids as substrates but also pharmaceutically relevant L-proline or GABA derivatives such as cis-4-hydroxy-L-proline, L-azetidine-2-carboxylic acid (LACA), 3-amino-1-propanesulfonic acid, nipecotic acid, and the antituberculotic agent D-cycloserine.	Proline	153-162	solute carrier family 36 member 1	Homo sapiens	20-59
16611863-4	2006	The degradation requires formation of a multiprotein complex (VHLCBC) and hydroxylation of HIF1A proline residues via members of the egg-laying-defective nine (EGLN) family.	Proline	97-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-96
16601143-0	2006	Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil.	Proline	98-105	deiodinase, iodothyronine type 1 L homeolog	Xenopus laevis	47-78
16531028-1	2006	The recently cloned proton-coupled amino acid transporter 1 (PAT1) not only accepts several amino acids as substrates but also pharmaceutically relevant L-proline or GABA derivatives such as cis-4-hydroxy-L-proline, L-azetidine-2-carboxylic acid (LACA), 3-amino-1-propanesulfonic acid, nipecotic acid, and the antituberculotic agent D-cycloserine.	Proline	153-162	solute carrier family 36 member 1	Homo sapiens	61-65
16818284-2	2006	The NQO1*2 variant enzyme (codon 609 C--&gt;T, encoding a proline to serine substitution) with greatly reduced activity has been reported to predispose to acute myeloid leukemia (AML).	Proline	58-65	NAD(P)H quinone dehydrogenase 1	Homo sapiens	4-8
16766089-1	2006	We synthesized proline and pyrrolidine-2-alkanoic acid derivatives in their enantiomerically pure form and evaluated them for their affinity to the GABA transport proteins GAT-1 and GAT-3.	Proline	15-22	solute carrier family 6 member 1	Homo sapiens	172-177
16766089-1	2006	We synthesized proline and pyrrolidine-2-alkanoic acid derivatives in their enantiomerically pure form and evaluated them for their affinity to the GABA transport proteins GAT-1 and GAT-3.	Proline	15-22	solute carrier family 6 member 13	Homo sapiens	182-187
16775352-2	2006	A proline-rich extensin-like receptor protein kinase (PERK) was found to interact specifically with NSP of Cabbage leaf curl virus (CaLCuV) and of tomato-infecting geminiviruses through a yeast two-hybrid screening.	Proline	2-9	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	100-103
16785532-6	2006	Binding by rituximab and mouse CD20 mAb, had an absolute requirement for alanine and proline at positions 170 and 172, respectively, within the large extracellular loop of CD20.	Proline	85-92	membrane-spanning 4-domains, subfamily A, member 1	Mus musculus	31-35
16785532-6	2006	Binding by rituximab and mouse CD20 mAb, had an absolute requirement for alanine and proline at positions 170 and 172, respectively, within the large extracellular loop of CD20.	Proline	85-92	membrane-spanning 4-domains, subfamily A, member 1	Mus musculus	172-176
16775352-3	2006	The PERK-like protein, which we designated NsAK (for NSP-associated kinase), is structurally organized into a proline-rich N-terminal domain, followed by a transmembrane segment and a C-terminal serine/threonine kinase domain.	Proline	110-117	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	53-56
16809279-2	2006	Alteration of arginine 332 in the TRIM5alpha(hu) B30.2 domain to proline, the residue found in rhesus monkey TRIM5alpha, has been shown to create a potent restricting factor for both HIV-1 and SIV(mac.)	Proline	65-72	tripartite motif containing 5	Macaca mulatta	34-44
16809279-2	2006	Alteration of arginine 332 in the TRIM5alpha(hu) B30.2 domain to proline, the residue found in rhesus monkey TRIM5alpha, has been shown to create a potent restricting factor for both HIV-1 and SIV(mac.)	Proline	65-72	tripartite motif containing 5	Macaca mulatta	109-119
16497731-6	2006	PTMs identified in murine and bovine adiponectin include hydroxylation of multiple conserved proline and lysine residues and glycosylation of hydroxylysines.	Proline	93-100	adiponectin, C1Q and collagen domain containing	Bos taurus	37-48
16786124-1	2006	The TP53 polymorphism occurs at codon 72 of exon 4 with two alleles encoding either arginine or proline.	Proline	96-103	tumor protein p53	Homo sapiens	4-8
16788378-9	2006	The proline substitution most likely destabilizes the BChE structure and causes the protein to be misfolded and rapidly degraded.	Proline	4-11	butyrylcholinesterase	Homo sapiens	54-58
17080945-7	2006	Expression of the A. thaliana ortholog of proline dehydrogenase (PDH), involved in proline catabolism, was undetectable in T. halophila shoots.	Proline	42-49	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	65-68
17080945-8	2006	The PDH enzyme activity was lower and T. halophila seedlings were hypersensitive to exogenous proline, indicating repression of proline catabolism in T. halophila.	Proline	128-135	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	4-7
16644721-9	2006	Using a phosphomitotic antibody, it was found that Btk harbors a bona fide MPM2 epitope corresponding to a phosphorylated serine or threonine residue followed by a proline.	Proline	164-171	Bruton tyrosine kinase	Homo sapiens	51-54
16636066-1	2006	Nck proteins are essential Src homology (SH) 2 and SH3 domain-bearing adapters that modulate actin cytoskeleton dynamics by linking proline-rich effector molecules to tyrosine kinases or phosphorylated signaling intermediates.	Proline	132-139	NCK adaptor protein 1	Homo sapiens	0-3
16939563-4	2006	Arginine can also be metabolized to urea and ornithine by arginase-1, a pathway that generates L-proline, a substrate for collagen synthesis, and polyamines, which stimulate cellular proliferation.	Proline	95-104	arginase 1	Homo sapiens	58-68
16800528-1	2006	Structural properties of the acidic proline rich protein PRP-1 of salivary origin in bulk solution and adsorbed onto a negatively charged surface have been studied by Monte Carlo simulations.	Proline	36-43	opiorphin prepropeptide	Homo sapiens	57-62
16784221-1	2006	4-Oxalocrotonate tautomerase (4-OT) and trans-3-chloroacrylic acid dehalogenase (CaaD) are members of the tautomerase superfamily, a group of structurally homologous proteins that share a beta-alpha-beta fold and a catalytic amino-terminal proline.	Proline	240-247	4-oxalocrotonate tautomerase	Pseudomonas putida	0-28
16730026-1	2006	Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor.	Proline	150-157	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-33
16730026-1	2006	Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor.	Proline	150-157	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-39
16730026-1	2006	Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor.	Proline	150-157	pyrroline-5-carboxylate reductase 1	Homo sapiens	108-140
16777958-1	2006	Ack/Ack1 is a nonreceptor protein tyrosine kinase that comprises a tyrosine kinase core, an SH3 domain, a Cdc42-binding region, a Ralt homology region, and a proline-rich region.	Proline	158-165	tyrosine kinase non receptor 2	Homo sapiens	0-3
16777958-1	2006	Ack/Ack1 is a nonreceptor protein tyrosine kinase that comprises a tyrosine kinase core, an SH3 domain, a Cdc42-binding region, a Ralt homology region, and a proline-rich region.	Proline	158-165	tyrosine kinase non receptor 2	Homo sapiens	4-8
16595656-5	2006	Using confocal microscopy and different truncated and point mutants of hENT1-YFP (yellow fluorescent protein) expressed in Madin-Darby canine kidney cells, we identified amino acid residues Pro(71),Glu(72), and Asn(74) (the PEXN motif) of hENT1 as important in mitochondrial targeting of hENT1.	Proline	190-193	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	71-76
16768443-2	2006	DPP-IV inactivates the glucagon-like peptide (GLP-1) and several other naturally produced bioactive peptides that contain preferentially a proline or alanine residue in the second amino acid sequence position by cleaving the N-terminal dipeptide.	Proline	139-146	dipeptidylpeptidase 4	Rattus norvegicus	0-6
16768443-2	2006	DPP-IV inactivates the glucagon-like peptide (GLP-1) and several other naturally produced bioactive peptides that contain preferentially a proline or alanine residue in the second amino acid sequence position by cleaving the N-terminal dipeptide.	Proline	139-146	glucagon	Rattus norvegicus	46-51
16462765-3	2006	A polymorphic site at codon 72 in exon 4 encodes either an arginine amino acid (Trp53(72R)) or a proline residue (Trp53(72P)).	Proline	97-104	tumor protein p53	Homo sapiens	114-119
16624262-1	2006	OBJECTIVE: In vitro experiments have shown that the ryanodine receptor-2 (RyR2) central domain peptide DPc10 (Gly(2460)-Pro(2495)) mimics channel dysfunction associated with catecholaminergic polymorphic ventricular tachycardia (CPVT) by acting competitively to reduce stabilizing interactions between the N-terminal and central domains.	Proline	120-123	ryanodine receptor 2	Homo sapiens	52-72
16712842-3	2006	Threonine-79 contributed to the weak proteasome-binding property of hHR23A, and its conversion to proline (T79P), which is the residue present in hHR23B, increased proteasome interaction.	Proline	98-105	RAD23 homolog A, nucleotide excision repair protein	Homo sapiens	68-74
16712842-3	2006	Threonine-79 contributed to the weak proteasome-binding property of hHR23A, and its conversion to proline (T79P), which is the residue present in hHR23B, increased proteasome interaction.	Proline	98-105	RAD23 homolog B, nucleotide excision repair protein	Homo sapiens	146-152
16460948-8	2006	The gamma-substituent in the proline moiety of both the (S)-2-cyanopyrrolidide and the thiazolidide may engage with the S(2) binding pocket of DPP-IV and thereby achieve hydrophobic interaction in the same manner.	Proline	29-36	dipeptidylpeptidase 4	Rattus norvegicus	143-149
16597650-2	2006	A proline-to-leucine substitution at prion protein (PrP) residue 102 (P102L), classically associated with the Gerstmann-Straussler-Scheinker (GSS) phenotype, also shows marked clinical and pathological heterogeneity, including patients with a Creutzfeldt-Jakob disease (CJD) phenotype.	Proline	2-9	prion protein	Homo sapiens	52-55
16752908-0	2006	Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins.	Proline	85-92	NCK adaptor protein 2	Homo sapiens	64-68
16752908-3	2006	In this study, we aimed to determine the NMR structures and dynamic properties of the hNck2 SH3 domains and to define their ligand binding preferences with nine proline-rich peptides derived from Wire, CAP-1, CAP-2, Prk, Wrch1, Wrch2, and Nogo.	Proline	161-168	NCK adaptor protein 2	Homo sapiens	86-91
16751508-2	2006	We altered intracellular proline levels by overexpressing the proline dehydrogenase gene (PUT1) of S. cerevisiae.	Proline	25-32	proline dehydrogenase	Saccharomyces cerevisiae S288C	90-94
16751508-3	2006	Put1p performs the first enzymatic step of proline degradation in S. cerevisiae.	Proline	43-50	proline dehydrogenase	Saccharomyces cerevisiae S288C	0-5
16751508-4	2006	Overexpression of Put1p results in low proline levels and hypersensitivity to oxidants, such as hydrogen peroxide and paraquat.	Proline	39-46	proline dehydrogenase	Saccharomyces cerevisiae S288C	18-23
16751508-5	2006	A put1-disrupted yeast mutant deficient in Put1p activity has increased protection from oxidative stress and increased proline levels.	Proline	119-126	proline dehydrogenase	Saccharomyces cerevisiae S288C	2-6
16751508-5	2006	A put1-disrupted yeast mutant deficient in Put1p activity has increased protection from oxidative stress and increased proline levels.	Proline	119-126	proline dehydrogenase	Saccharomyces cerevisiae S288C	43-48
16751508-8	2006	A yeast two-hybrid system assay was used to show that tQM physically interacts with Put1p in yeast, suggesting that tQM is directly involved in modulating proline levels.	Proline	155-162	proline dehydrogenase	Saccharomyces cerevisiae S288C	84-89
16624262-1	2006	OBJECTIVE: In vitro experiments have shown that the ryanodine receptor-2 (RyR2) central domain peptide DPc10 (Gly(2460)-Pro(2495)) mimics channel dysfunction associated with catecholaminergic polymorphic ventricular tachycardia (CPVT) by acting competitively to reduce stabilizing interactions between the N-terminal and central domains.	Proline	120-123	ryanodine receptor 2	Homo sapiens	74-78
16406204-8	2006	In contrast, PEP hydrolyzed human urotensin II at the canonical post-proline site.	Proline	69-76	prolyl endopeptidase	Homo sapiens	13-16
16723809-10	2006	Sequencing of the TR beta gene showed that the patient and her father had a codon 453 mutation resulting in a CCT (proline) to ACT (threonine) substitution.	Proline	115-122	T cell receptor beta locus	Homo sapiens	18-25
16641196-7	2006	Mutation of a proline residue within this sequence to glutamic acid reduces its interaction with Hsp90, inhibits homodimer formation, and reduces its half-life to 4 h. These findings implicate Hsp90 in the stabilization of LIMK1 by promoting homodimer formation and transphosphorylation.	Proline	14-21	heat shock protein 90 alpha family class A member 1	Homo sapiens	97-102
16641196-7	2006	Mutation of a proline residue within this sequence to glutamic acid reduces its interaction with Hsp90, inhibits homodimer formation, and reduces its half-life to 4 h. These findings implicate Hsp90 in the stabilization of LIMK1 by promoting homodimer formation and transphosphorylation.	Proline	14-21	heat shock protein 90 alpha family class A member 1	Homo sapiens	193-198
16641196-7	2006	Mutation of a proline residue within this sequence to glutamic acid reduces its interaction with Hsp90, inhibits homodimer formation, and reduces its half-life to 4 h. These findings implicate Hsp90 in the stabilization of LIMK1 by promoting homodimer formation and transphosphorylation.	Proline	14-21	LIM domain kinase 1	Homo sapiens	223-228
16753841-0	2006	Peroxynitrite as an alternative donor of oxygen in HIF-1alpha proline hydroxylation under low oxygen availability.	Proline	62-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
16753841-4	2006	Here, we propose a hypothesis that peroxynitrite, formed in the cells upon exposure to NO under low oxygen availability, serves as an alternative donor of oxygen for activated PHDs so they can perform HIF-1alpha proline hydroxylation to de-accumulate the protein.	Proline	212-219	hypoxia inducible factor 1 subunit alpha	Homo sapiens	201-211
16731932-4	2006	Blocking expression of the proline-rich 11-kDa protein significantly reduced B19 viral infectivity, and protein studies suggested that the expression of the 11-kDa protein was critical for VP2 capsid production and trafficking in infected cells.	Proline	27-34	eva-1 homolog C	Homo sapiens	77-80
16652378-2	2006	Recent studies indicate that certain pSer/Thr-Pro motifs in native proteins exist in two completely distinct conformations, cis and trans, whose conversion is markedly slowed down upon phosphorylation, but specifically catalyzed by the peptidyl-prolyl cis/trans isomerase Pin1.	Proline	46-49	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	272-276
16511445-7	2006	DYRK1A and DYRK2 counter calcineurin-mediated dephosphorylation of NFAT1 by directly phosphorylating the conserved serine-proline repeat 3 (SP-3) motif of the NFAT regulatory domain, thus priming further phosphorylation of the SP-2 and serine-rich region 1 (SRR-1) motifs by GSK3 and CK1, respectively.	Proline	122-129	Calcineurin A1	Drosophila melanogaster	25-36
16511445-7	2006	DYRK1A and DYRK2 counter calcineurin-mediated dephosphorylation of NFAT1 by directly phosphorylating the conserved serine-proline repeat 3 (SP-3) motif of the NFAT regulatory domain, thus priming further phosphorylation of the SP-2 and serine-rich region 1 (SRR-1) motifs by GSK3 and CK1, respectively.	Proline	122-129	NFAT nuclear factor	Drosophila melanogaster	67-71
16756746-3	2006	After secretion, dipeptidyl peptidase IV (DPP-IV) cleaves the N-terminal Tyrosine-Proline residues from PYY(1-36), producing PYY(3-36).	Proline	82-89	dipeptidyl peptidase 4	Homo sapiens	17-40
16756746-3	2006	After secretion, dipeptidyl peptidase IV (DPP-IV) cleaves the N-terminal Tyrosine-Proline residues from PYY(1-36), producing PYY(3-36).	Proline	82-89	dipeptidyl peptidase 4	Homo sapiens	42-48
16756746-3	2006	After secretion, dipeptidyl peptidase IV (DPP-IV) cleaves the N-terminal Tyrosine-Proline residues from PYY(1-36), producing PYY(3-36).	Proline	82-89	peptide YY	Homo sapiens	104-107
16756746-3	2006	After secretion, dipeptidyl peptidase IV (DPP-IV) cleaves the N-terminal Tyrosine-Proline residues from PYY(1-36), producing PYY(3-36).	Proline	82-89	peptide YY	Homo sapiens	125-128
16729222-13	2006	Pro(9) SP, a high-affinity substrate for the NK-1 major subtype receptor, significantly (p &lt; 0.05) inhibited the transport of SP.	Proline	0-4	tachykinin precursor 1	Homo sapiens	45-49
16574760-1	2006	BACKGROUND: Several proteolytically derived fragments from the proline-rich region (PRR) of human inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) have been identified by surface-enhanced or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS or MALDI-TOF-MS) as potential disease markers.	Proline	63-70	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	98-141
16574760-1	2006	BACKGROUND: Several proteolytically derived fragments from the proline-rich region (PRR) of human inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) have been identified by surface-enhanced or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS or MALDI-TOF-MS) as potential disease markers.	Proline	63-70	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	143-148
16702321-8	2006	In conclusion, in inflammatory situations, an increase in threonine, serine, proline, and cysteine dietary supply can promote mucin synthesis, reequilibrate the gut microbiota, and thus favor colonic protection and mucosal healing.	Proline	77-84	solute carrier family 13 member 2	Rattus norvegicus	126-131
16406204-8	2006	In contrast, PEP hydrolyzed human urotensin II at the canonical post-proline site.	Proline	69-76	urotensin 2	Homo sapiens	34-46
16670293-5	2006	We found that p202 bound to p53 in the N-terminal region (aa 44-83) comprising the proline-rich region that is important for p53-mediated apoptosis.	Proline	83-90	interferon activated gene 202B	Mus musculus	14-18
16706410-2	2006	The molecules studied are models for the phospho-Ser/Thr-Pro substrate for Pin-1, a peptidyl-prolyl isomerase (PPIase) involved in cell division.	Proline	57-60	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	75-80
16706410-2	2006	The molecules studied are models for the phospho-Ser/Thr-Pro substrate for Pin-1, a peptidyl-prolyl isomerase (PPIase) involved in cell division.	Proline	57-60	peptidylprolyl isomerase like 3	Homo sapiens	84-109
16706410-2	2006	The molecules studied are models for the phospho-Ser/Thr-Pro substrate for Pin-1, a peptidyl-prolyl isomerase (PPIase) involved in cell division.	Proline	57-60	peptidylprolyl isomerase like 3	Homo sapiens	111-117
16706410-3	2006	Pin-1 requires phosphorylation of a Ser or Thr residue adjacent to a Pro residue in the substrate and catalyzes cis-trans isomerization about the proline amide bond.	Proline	69-72	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-5
16783873-2	2006	Proline-rich proteins like vinculin and zyxin are well established interaction partners, which mediate Ena/VASP-recruitment via their EVH1-domains to focal adhesions and stress fibres.	Proline	0-7	Vinculin	Caenorhabditis elegans	27-35
16783873-4	2006	Here, we report the identification of a novel protein with high similarity to the C. elegans MIG-10 protein, which we termed PREL1 (Proline Rich EVH1 Ligand).	Proline	132-139	Abnormal cell migration protein 10	Caenorhabditis elegans	93-99
16565146-8	2006	In most of the receptors coupling to Gs family, the occurrence of proline on the position corresponding to the 170th residue on rhodopsin is rare.	Proline	66-73	rhodopsin	Homo sapiens	128-137
16407834-3	2006	Here we show that the SH3 domain of betaPix specifically interacts with a proline-arginine motif (PxxxPR) present within the ubiquitin ligase Cbl and Pak1 kinase.	Proline	74-81	Rho guanine nucleotide exchange factor 7	Homo sapiens	36-43
16407834-3	2006	Here we show that the SH3 domain of betaPix specifically interacts with a proline-arginine motif (PxxxPR) present within the ubiquitin ligase Cbl and Pak1 kinase.	Proline	74-81	Cbl proto-oncogene	Homo sapiens	142-145
16407834-3	2006	Here we show that the SH3 domain of betaPix specifically interacts with a proline-arginine motif (PxxxPR) present within the ubiquitin ligase Cbl and Pak1 kinase.	Proline	74-81	p21 (RAC1) activated kinase 1	Homo sapiens	150-154
16460309-2	2006	Although previous analysis of a crystal structure has demonstrated that the tandem SH3 domains of p47phox sandwich a short PRR (proline-rich region) of p22phox (amino acids 151-160), containing a polyproline II helix, it has remained unknown whether this model is indeed functional in activation of the oxidase.	Proline	128-135	neutrophil cytosolic factor 1	Homo sapiens	98-105
16460309-2	2006	Although previous analysis of a crystal structure has demonstrated that the tandem SH3 domains of p47phox sandwich a short PRR (proline-rich region) of p22phox (amino acids 151-160), containing a polyproline II helix, it has remained unknown whether this model is indeed functional in activation of the oxidase.	Proline	128-135	cytochrome b-245 alpha chain	Homo sapiens	152-159
16670293-5	2006	We found that p202 bound to p53 in the N-terminal region (aa 44-83) comprising the proline-rich region that is important for p53-mediated apoptosis.	Proline	83-90	transformation related protein 53, pseudogene	Mus musculus	28-31
16461356-2	2006	While primary binding occurs via SKAP-55 SH3 domain binding to a proline-rich region in ADAP, a second interaction occurs between the ADAP C-terminal SH3 domain (ADAP-SH3c) and a non-canonical RKXXY294XXY297 motif in SKAP-55.	Proline	65-72	src kinase associated phosphoprotein 1	Homo sapiens	33-40
16670293-5	2006	We found that p202 bound to p53 in the N-terminal region (aa 44-83) comprising the proline-rich region that is important for p53-mediated apoptosis.	Proline	83-90	transformation related protein 53, pseudogene	Mus musculus	125-128
16461356-2	2006	While primary binding occurs via SKAP-55 SH3 domain binding to a proline-rich region in ADAP, a second interaction occurs between the ADAP C-terminal SH3 domain (ADAP-SH3c) and a non-canonical RKXXY294XXY297 motif in SKAP-55.	Proline	65-72	FYN binding protein 1	Homo sapiens	88-92
16670299-2	2006	Th1-type cytokines induce NO synthase 2, which metabolizes arginine into nitrites, while the Th2-type cytokines produce arginase, which converts arginine into polyamines and proline.	Proline	174-181	negative elongation factor complex member C/D, Th1l	Mus musculus	0-3
16670299-2	2006	Th1-type cytokines induce NO synthase 2, which metabolizes arginine into nitrites, while the Th2-type cytokines produce arginase, which converts arginine into polyamines and proline.	Proline	174-181	heart and neural crest derivatives expressed 2	Mus musculus	93-96
16619031-3	2006	The Sld2 protein has a cluster of 11 cyclin-dependent kinase (CDK) phosphorylation motifs (Ser/Thr-Pro), six of which match the canonical sequences Ser/Thr-Pro-X-Lys/Arg, Lys/Arg-Ser/Thr-Pro and Ser/Thr-Pro-Lys/Arg.	Proline	99-102	Sld2p	Saccharomyces cerevisiae S288C	4-8
16531412-6	2006	The interaction is mediated by the VASP EVH1 domain and a single L104PPPPP site located within the migfilin proline-rich domain.	Proline	108-115	vasodilator stimulated phosphoprotein	Homo sapiens	35-39
16531412-6	2006	The interaction is mediated by the VASP EVH1 domain and a single L104PPPPP site located within the migfilin proline-rich domain.	Proline	108-115	filamin binding LIM protein 1	Homo sapiens	99-107
16540119-0	2006	Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain.	Proline	47-54	hematopoietically expressed homeobox	Homo sapiens	73-76
16540119-0	2006	Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain.	Proline	47-54	hematopoietically expressed homeobox	Homo sapiens	77-80
16540119-0	2006	Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain.	Proline	105-112	hematopoietically expressed homeobox	Homo sapiens	73-76
16540119-0	2006	Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain.	Proline	105-112	hematopoietically expressed homeobox	Homo sapiens	77-80
16540119-8	2006	We show that this region of PRH contains a novel proline-rich dimerisation domain that mediates oligomerisation.	Proline	49-56	hematopoietically expressed homeobox	Homo sapiens	28-31
16520377-8	2006	Capitalizing on its unique preference for proline and glycine at the P2 and P3 positions, respectively, selective substrates and a substrate-based inhibitor were developed for cathepsin K.	Proline	42-49	cathepsin K	Homo sapiens	176-187
16619031-3	2006	The Sld2 protein has a cluster of 11 cyclin-dependent kinase (CDK) phosphorylation motifs (Ser/Thr-Pro), six of which match the canonical sequences Ser/Thr-Pro-X-Lys/Arg, Lys/Arg-Ser/Thr-Pro and Ser/Thr-Pro-Lys/Arg.	Proline	156-159	Sld2p	Saccharomyces cerevisiae S288C	4-8
16619031-3	2006	The Sld2 protein has a cluster of 11 cyclin-dependent kinase (CDK) phosphorylation motifs (Ser/Thr-Pro), six of which match the canonical sequences Ser/Thr-Pro-X-Lys/Arg, Lys/Arg-Ser/Thr-Pro and Ser/Thr-Pro-Lys/Arg.	Proline	156-159	Sld2p	Saccharomyces cerevisiae S288C	4-8
16627619-0	2006	Homodimerization of the G protein SRbeta in the nucleotide-free state involves proline cis/trans isomerization in the switch II region.	Proline	79-86	chaperonin containing TCP1 subunit 4	Homo sapiens	34-40
16619031-3	2006	The Sld2 protein has a cluster of 11 cyclin-dependent kinase (CDK) phosphorylation motifs (Ser/Thr-Pro), six of which match the canonical sequences Ser/Thr-Pro-X-Lys/Arg, Lys/Arg-Ser/Thr-Pro and Ser/Thr-Pro-Lys/Arg.	Proline	156-159	Sld2p	Saccharomyces cerevisiae S288C	4-8
16734764-2	2006	As the transport process performed by SNAT2 is highly energized, system A substrates, such as glutamine, glycine, proline and alanine, reach high transmembrane gradients and constitute major components of the intracellular amino acid pool.	Proline	114-121	solute carrier family 38 member 2	Homo sapiens	38-43
16636290-7	2006	We found that AMAP1/cortactin binding is very atypical in its stoichiometry and interface structure, in which one AMAP1 proline-rich peptide binds to two cortactin SH3 domains simultaneously.	Proline	120-127	cortactin	Mus musculus	154-163
16636290-8	2006	We made a cell-permeable peptide derived from the AMAP1 peptide, and we show that this peptide specifically blocks AMAP1/cortactin binding, but not other canonical SH3/proline bindings, and effectively inhibits breast cancer invasion and metastasis.	Proline	168-175	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	50-55
16636290-8	2006	We made a cell-permeable peptide derived from the AMAP1 peptide, and we show that this peptide specifically blocks AMAP1/cortactin binding, but not other canonical SH3/proline bindings, and effectively inhibits breast cancer invasion and metastasis.	Proline	168-175	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	115-120
16636290-8	2006	We made a cell-permeable peptide derived from the AMAP1 peptide, and we show that this peptide specifically blocks AMAP1/cortactin binding, but not other canonical SH3/proline bindings, and effectively inhibits breast cancer invasion and metastasis.	Proline	168-175	cortactin	Homo sapiens	121-130
16636290-10	2006	We also found that a small-molecule compound, UCS15A, which was previously judged as a weak inhibitor against canonical SH3/proline bindings, effectively inhibits AMAP1/cortactin binding and breast cancer invasion and metastasis.	Proline	124-131	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	163-168
16636290-0	2006	Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.	Proline	73-80	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	10-15
16636290-0	2006	Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.	Proline	73-80	cortactin	Homo sapiens	20-29
16636290-5	2006	In this complex, AMAP1 binds to the src homology 3 (SH3) domain of cortactin via its proline-rich peptide, SKKRPPPPPPGHKRT.	Proline	85-92	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	17-22
16636290-5	2006	In this complex, AMAP1 binds to the src homology 3 (SH3) domain of cortactin via its proline-rich peptide, SKKRPPPPPPGHKRT.	Proline	85-92	cortactin	Homo sapiens	67-76
16636290-7	2006	We found that AMAP1/cortactin binding is very atypical in its stoichiometry and interface structure, in which one AMAP1 proline-rich peptide binds to two cortactin SH3 domains simultaneously.	Proline	120-127	MYCBP associated protein	Mus musculus	14-19
16636290-7	2006	We found that AMAP1/cortactin binding is very atypical in its stoichiometry and interface structure, in which one AMAP1 proline-rich peptide binds to two cortactin SH3 domains simultaneously.	Proline	120-127	cortactin	Mus musculus	20-29
16636290-7	2006	We found that AMAP1/cortactin binding is very atypical in its stoichiometry and interface structure, in which one AMAP1 proline-rich peptide binds to two cortactin SH3 domains simultaneously.	Proline	120-127	MYCBP associated protein	Mus musculus	114-119
16751601-8	2006	The first SH3 domain and the C-terminal region of CIN85 bind to the proline-rich region and the N-terminal region of dendrin, respectively.	Proline	68-75	SH3 domain containing kinase binding protein 1	Homo sapiens	50-55
16642978-1	2006	A new method for prolidase (PLD, EC 3.4.13.9) activity assay was developed based on the determination of proline produced from enzymatic reaction through capillary electrophoresis (CE) with tris(2,2"-bipyridyl)ruthenium(II) [Ru(bpy)3(2+)] electrochemiluminescence detection (ECL).	Proline	105-112	peptidase D	Homo sapiens	17-26
16642978-1	2006	A new method for prolidase (PLD, EC 3.4.13.9) activity assay was developed based on the determination of proline produced from enzymatic reaction through capillary electrophoresis (CE) with tris(2,2"-bipyridyl)ruthenium(II) [Ru(bpy)3(2+)] electrochemiluminescence detection (ECL).	Proline	105-112	peptidase D	Homo sapiens	28-31
16642978-2	2006	A detection limit of 12.2 fmol (S/N = 3) for proline, corresponding to 1.22 x 10(-8) units of prolidase catalyzing for 1 min was achieved.	Proline	45-52	peptidase D	Homo sapiens	94-103
16580895-6	2006	Removal of Pro128 from the hepatic SDH consisting of 328 residues, which is missing in the corresponding position of the isoform consisting of 329 residues, significantly changed the Michaelis constants and Kd value for pyridoxal 5"-phosphate, whereas addition of a proline residue to the isoform was without effect.	Proline	266-273	serine dehydratase	Homo sapiens	35-38
16634881-3	2006	Prolidase, an imidodipeptide-cleaving cytosolic enzyme, plays an important role in the collagen catabolic process by recycling proline for collagen synthesis.	Proline	127-134	peptidase D	Homo sapiens	0-9
16371438-10	2006	Furthermore, GM-CSF induced an increase in arginase activity and in the conversion of L-arginine to ornithine, citrulline, glutamate, proline, and polyamines.	Proline	134-141	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	13-19
16439675-5	2006	We further demonstrated that interaction of MIST with Fgr, mediated by the C-terminal proline-rich region of MIST and the SH3 domain of Fgr, was required for the suppression of NK-cell receptor-induced IFN-gamma production.	Proline	86-93	cytokine-dependent hematopoietic cell linker	Mus musculus	44-48
16439675-5	2006	We further demonstrated that interaction of MIST with Fgr, mediated by the C-terminal proline-rich region of MIST and the SH3 domain of Fgr, was required for the suppression of NK-cell receptor-induced IFN-gamma production.	Proline	86-93	FGR proto-oncogene, Src family tyrosine kinase	Mus musculus	54-57
16439675-5	2006	We further demonstrated that interaction of MIST with Fgr, mediated by the C-terminal proline-rich region of MIST and the SH3 domain of Fgr, was required for the suppression of NK-cell receptor-induced IFN-gamma production.	Proline	86-93	cytokine-dependent hematopoietic cell linker	Mus musculus	109-113
16439675-5	2006	We further demonstrated that interaction of MIST with Fgr, mediated by the C-terminal proline-rich region of MIST and the SH3 domain of Fgr, was required for the suppression of NK-cell receptor-induced IFN-gamma production.	Proline	86-93	FGR proto-oncogene, Src family tyrosine kinase	Mus musculus	136-139
16439675-5	2006	We further demonstrated that interaction of MIST with Fgr, mediated by the C-terminal proline-rich region of MIST and the SH3 domain of Fgr, was required for the suppression of NK-cell receptor-induced IFN-gamma production.	Proline	86-93	interferon gamma	Mus musculus	202-211
16628753-1	2006	Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy termini of the proline residues.	Proline	70-77	prolyl endopeptidase	Homo sapiens	0-21
16628753-1	2006	Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy termini of the proline residues.	Proline	128-135	prolyl endopeptidase	Homo sapiens	0-21
16573649-9	2006	Moreover, the proline containing region (VIENP) of the NPXY motif is also required for FRS2 and SHC phosphorylation, which indicates this region is an important component of FRS2 and SHC recognition by TrkB.	Proline	14-21	fibroblast growth factor receptor substrate 2	Homo sapiens	87-91
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Proline	51-54	tumor protein p53	Homo sapiens	47-50
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Proline	55-58	tumor protein p53	Homo sapiens	47-50
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Proline	55-58	tumor protein p53	Homo sapiens	47-50
16573649-9	2006	Moreover, the proline containing region (VIENP) of the NPXY motif is also required for FRS2 and SHC phosphorylation, which indicates this region is an important component of FRS2 and SHC recognition by TrkB.	Proline	14-21	SHC adaptor protein 1	Homo sapiens	96-99
16606361-3	2006	We used the divergent C-terminus of VGLUT1 as a bait in a yeast two-hybrid screen to identify and map the interaction between a proline-rich domain of VGLUT1 and the Src homology domain 3 (SH3) domain of endophilin.	Proline	128-135	solute carrier family 17 member 7	Rattus norvegicus	36-42
16606361-3	2006	We used the divergent C-terminus of VGLUT1 as a bait in a yeast two-hybrid screen to identify and map the interaction between a proline-rich domain of VGLUT1 and the Src homology domain 3 (SH3) domain of endophilin.	Proline	128-135	solute carrier family 17 member 7	Rattus norvegicus	151-157
16573649-9	2006	Moreover, the proline containing region (VIENP) of the NPXY motif is also required for FRS2 and SHC phosphorylation, which indicates this region is an important component of FRS2 and SHC recognition by TrkB.	Proline	14-21	fibroblast growth factor receptor substrate 2	Homo sapiens	174-178
16573649-9	2006	Moreover, the proline containing region (VIENP) of the NPXY motif is also required for FRS2 and SHC phosphorylation, which indicates this region is an important component of FRS2 and SHC recognition by TrkB.	Proline	14-21	SHC adaptor protein 1	Homo sapiens	183-186
16772869-1	2006	The mitogen-activated protein (MAP) kinase SAPK/JNK phosphorylates tau protein at many of its proline-directed serine/threonine residues in vitro and is a likely candidate kinase to phosphorylate the pathologically relevant S422 site on tau.	Proline	94-101	mitogen-activated protein kinase 9	Homo sapiens	43-47
16772869-1	2006	The mitogen-activated protein (MAP) kinase SAPK/JNK phosphorylates tau protein at many of its proline-directed serine/threonine residues in vitro and is a likely candidate kinase to phosphorylate the pathologically relevant S422 site on tau.	Proline	94-101	mitogen-activated protein kinase 8	Homo sapiens	48-51
16674107-0	2006	Proteomic analysis of MCF-7 cell lines expressing the zinc-finger or the proline-rich domain of retinoblastoma-interacting-zinc-finger protein.	Proline	73-80	PR/SET domain 2	Homo sapiens	96-134
16772869-1	2006	The mitogen-activated protein (MAP) kinase SAPK/JNK phosphorylates tau protein at many of its proline-directed serine/threonine residues in vitro and is a likely candidate kinase to phosphorylate the pathologically relevant S422 site on tau.	Proline	94-101	microtubule associated protein tau	Homo sapiens	67-70
16772869-1	2006	The mitogen-activated protein (MAP) kinase SAPK/JNK phosphorylates tau protein at many of its proline-directed serine/threonine residues in vitro and is a likely candidate kinase to phosphorylate the pathologically relevant S422 site on tau.	Proline	94-101	microtubule associated protein tau	Homo sapiens	237-240
16674107-1	2006	To identify a growth-promoting activity related to retinoblastoma-interacting-zinc-finger (RIZ) protein, differential protein expression of MCF-7 cell lines expressing the zinc-finger or the proline-rich domain of RIZ protein was analyzed by a robust bottom-up mass-spectrometry proteomic approach.	Proline	191-198	PR/SET domain 2	Homo sapiens	91-94
16641261-9	2006	We propose that cyclophilin A isomerization of a proline residue in the TRIM5alpha sensitivity determinant of the HIV-1 capsid sensitizes it to restriction by Old World monkey TRIM5alpha.	Proline	49-56	tripartite motif containing 5	Homo sapiens	72-82
16641261-9	2006	We propose that cyclophilin A isomerization of a proline residue in the TRIM5alpha sensitivity determinant of the HIV-1 capsid sensitizes it to restriction by Old World monkey TRIM5alpha.	Proline	49-56	tripartite motif containing 5	Homo sapiens	176-186
16674107-1	2006	To identify a growth-promoting activity related to retinoblastoma-interacting-zinc-finger (RIZ) protein, differential protein expression of MCF-7 cell lines expressing the zinc-finger or the proline-rich domain of RIZ protein was analyzed by a robust bottom-up mass-spectrometry proteomic approach.	Proline	191-198	PR/SET domain 2	Homo sapiens	51-89
16674107-1	2006	To identify a growth-promoting activity related to retinoblastoma-interacting-zinc-finger (RIZ) protein, differential protein expression of MCF-7 cell lines expressing the zinc-finger or the proline-rich domain of RIZ protein was analyzed by a robust bottom-up mass-spectrometry proteomic approach.	Proline	191-198	PR/SET domain 2	Homo sapiens	214-217
16648477-3	2006	Deletion and point mutations in TAB1 reveal that a proline residue in the C terminus of TAB1 (Pro412) is necessary for its interaction with p38alpha.	Proline	51-58	mitogen-activated protein kinase 14	Homo sapiens	140-148
16525023-6	2006	We demonstrated that the interaction is mediated by the binding of PLC-gamma1 Src homology (SH) 3 domain to Akt proline-rich motifs.	Proline	112-119	phospholipase C gamma 1	Homo sapiens	67-77
16525023-6	2006	We demonstrated that the interaction is mediated by the binding of PLC-gamma1 Src homology (SH) 3 domain to Akt proline-rich motifs.	Proline	112-119	AKT serine/threonine kinase 1	Homo sapiens	108-111
16525023-7	2006	We also provide a novel model to depict how the interaction between PLC-gamma1 SH3 domain and Akt proline-rich motifs is dependent on EGF stimulation.	Proline	98-105	phospholipase C gamma 1	Homo sapiens	68-78
16525023-7	2006	We also provide a novel model to depict how the interaction between PLC-gamma1 SH3 domain and Akt proline-rich motifs is dependent on EGF stimulation.	Proline	98-105	AKT serine/threonine kinase 1	Homo sapiens	94-97
16430883-2	2006	LASP-1 is an actin binding protein, which also interacts with the proline-rich domains of zyxin, a scaffolding protein required for cell movement and gene transcription.	Proline	66-73	LIM and SH3 protein 1	Homo sapiens	0-6
16525023-8	2006	In this model, phosphorylation of PLC-gamma1 Y783 by EGF causes the conformational change of PLC-gamma1 to allow the interaction of its SH3 domain with Akt proline-rich motifs.	Proline	156-163	phospholipase C gamma 1	Homo sapiens	34-44
16525023-8	2006	In this model, phosphorylation of PLC-gamma1 Y783 by EGF causes the conformational change of PLC-gamma1 to allow the interaction of its SH3 domain with Akt proline-rich motifs.	Proline	156-163	phospholipase C gamma 1	Homo sapiens	93-103
16525023-8	2006	In this model, phosphorylation of PLC-gamma1 Y783 by EGF causes the conformational change of PLC-gamma1 to allow the interaction of its SH3 domain with Akt proline-rich motifs.	Proline	156-163	AKT serine/threonine kinase 1	Homo sapiens	152-155
16484282-2	2006	Here we report the identification and transcriptional characterization of mouse Sim2s, a splice variant of Sim2, which is missing the carboxyl Pro/Ala-rich repressive domain.	Proline	143-146	single-minded family bHLH transcription factor 2	Mus musculus	80-84
16687037-7	2006	After release, dipeptidyl peptidase IV (DPP-IV; CD 26) cleaves the N-terminal tyrosine-proline residues forming PYY(3-36).	Proline	87-94	dipeptidyl peptidase 4	Homo sapiens	15-38
16687037-7	2006	After release, dipeptidyl peptidase IV (DPP-IV; CD 26) cleaves the N-terminal tyrosine-proline residues forming PYY(3-36).	Proline	87-94	dipeptidyl peptidase 4	Homo sapiens	40-46
16687037-7	2006	After release, dipeptidyl peptidase IV (DPP-IV; CD 26) cleaves the N-terminal tyrosine-proline residues forming PYY(3-36).	Proline	87-94	peptide YY	Homo sapiens	112-115
16457816-4	2006	However, the Rin1:N deletion mutant, which contains both the SH2 and proline-rich domains, blocked insulin-stimulated receptor-mediated and insulin-stimulated fluid phase endocytosis.	Proline	69-76	Ras and Rab interactor 1	Homo sapiens	13-17
16430883-2	2006	LASP-1 is an actin binding protein, which also interacts with the proline-rich domains of zyxin, a scaffolding protein required for cell movement and gene transcription.	Proline	66-73	zyxin	Homo sapiens	90-95
16569658-8	2006	Cells expressing mutants defective in binding proline-rich ligands (profilin I(W3A) and profilin I(R136D)) differentiated faster, developed more and longer neurites and more branches.	Proline	46-53	profilin 1	Rattus norvegicus	68-82
16569658-8	2006	Cells expressing mutants defective in binding proline-rich ligands (profilin I(W3A) and profilin I(R136D)) differentiated faster, developed more and longer neurites and more branches.	Proline	46-53	profilin 1	Rattus norvegicus	68-78
16569658-13	2006	Taken together, our data show the importance of the interaction of profilin I with actin, proline-rich proteins and phosphatidylinositol 4,5-bisphosphate in neuronal differentiation of PC12 cells.	Proline	90-97	profilin 1	Rattus norvegicus	67-77
16634782-8	2006	Substrate inhibition studies confirmed that intestinal proline absorption in rat occurs mainly by system B and PAT1-like transporter.	Proline	55-62	solute carrier family 36 member 1	Rattus norvegicus	111-115
16599534-1	2006	The conformers of gaseous bradykinin, BK, (Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)) and its protonated forms, [BK + H](+), [BK + 2H](2+), and [BK + 3H](3+), were examined theoretically using a combination of the Merck molecular force field, Hartree-Fock, and density functional theory.	Proline	50-53	kininogen 1	Homo sapiens	26-36
16599534-1	2006	The conformers of gaseous bradykinin, BK, (Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)) and its protonated forms, [BK + H](+), [BK + 2H](2+), and [BK + 3H](3+), were examined theoretically using a combination of the Merck molecular force field, Hartree-Fock, and density functional theory.	Proline	57-60	kininogen 1	Homo sapiens	26-36
16446360-7	2006	Three serine/proline sites were identified for Cdk2 and Cdk1, and a unique site was phosphorylated by CK2.	Proline	13-20	cyclin dependent kinase 2	Homo sapiens	47-51
16446360-7	2006	Three serine/proline sites were identified for Cdk2 and Cdk1, and a unique site was phosphorylated by CK2.	Proline	13-20	cyclin dependent kinase 1	Homo sapiens	56-60
16595635-5	2006	Nck binds to the proline-rich portion of FasL and alters its subcellular distribution when coexpressed in 293T cells.	Proline	17-24	NCK adaptor protein 1	Homo sapiens	0-3
16595635-5	2006	Nck binds to the proline-rich portion of FasL and alters its subcellular distribution when coexpressed in 293T cells.	Proline	17-24	Fas ligand	Homo sapiens	41-45
16566597-0	2006	Role of conserved prolines in the structure and function of the Na+/dicarboxylate cotransporter 1, NaDC1.	Proline	18-26	solute carrier family 13 member 2	Oryctolagus cuniculus	64-97
16566597-0	2006	Role of conserved prolines in the structure and function of the Na+/dicarboxylate cotransporter 1, NaDC1.	Proline	18-26	solute carrier family 13 member 2	Oryctolagus cuniculus	99-104
16566597-2	2006	The sequence of NaDC1 contains a number of conserved proline residues in predicted transmembrane helices (TMs) 7 and 10.	Proline	53-60	solute carrier family 13 member 2	Oryctolagus cuniculus	16-21
16480678-5	2006	We subsequently describe a very rapid 96-well screening of inhibitors based on a simple competition between purified Grb2 and a peroxidase-coupled proline-rich peptide.	Proline	147-154	growth factor receptor bound protein 2	Homo sapiens	117-121
16354758-3	2006	We previously reported that treatment with NO decreases phosphotyrosine levels of adapter protein p130(cas) by increasing protein tyrosine phosphatase-proline, glutamate, serine, and threonine sequence protein (PTP-PEST) activity, which leads to the suppression of agonist-induced H(2)O(2) elevation and motility in cultured rat aortic smooth muscle cells (SMCs).	Proline	151-158	phospholipase C-like 1	Rattus norvegicus	98-102
16616333-0	2006	A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.	Proline	31-38	transformation related protein 53, pseudogene	Mus musculus	8-11
16478649-2	2006	A structurally unique member of the family is galectin-3; in addition to the CRD it contains a proline- and glycine-rich N-terminal domain (ND) through which is able to form oligomers.	Proline	95-102	galectin 3	Homo sapiens	46-56
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Proline	97-100	tumor protein p53 binding protein 1	Homo sapiens	66-72
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Proline	97-100	tumor protein p53	Homo sapiens	88-91
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Proline	97-100	tumor protein p53 binding protein 1	Homo sapiens	191-197
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Proline	97-100	tumor protein p53	Homo sapiens	222-225
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Proline	232-235	tumor protein p53 binding protein 1	Homo sapiens	66-72
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Proline	232-235	tumor protein p53	Homo sapiens	88-91
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Proline	232-235	tumor protein p53 binding protein 1	Homo sapiens	191-197
16332972-7	2006	Localization to lipid rafts appears to be predominantly mediated by the characteristic cytoplasmic proline-rich domain of Fas ligand because mutations of this domain result in reduced recruitment to lipid rafts and attenuated Fas ligand killing activity.	Proline	99-106	Fas ligand	Homo sapiens	122-132
16332972-7	2006	Localization to lipid rafts appears to be predominantly mediated by the characteristic cytoplasmic proline-rich domain of Fas ligand because mutations of this domain result in reduced recruitment to lipid rafts and attenuated Fas ligand killing activity.	Proline	99-106	Fas ligand	Homo sapiens	226-236
16585195-4	2006	Hydroxylation of two proline residues by prolyl hydroxylase domain (PHD) 2 protein earmarks the protein for degradation, whereas hydroxylation of an asparagine residue by factor-inhibiting HIF-1 (FIH-1 or FIH) reduces its transcriptional activity.	Proline	21-28	egl-9 family hypoxia inducible factor 1	Homo sapiens	68-74
16616333-0	2006	A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.	Proline	31-38	transformed mouse 3T3 cell double minute 4	Mus musculus	59-63
16616333-0	2006	A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.	Proline	31-38	transformed mouse 3T3 cell double minute 2	Mus musculus	105-109
16616333-0	2006	A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.	Proline	31-38	transformed mouse 3T3 cell double minute 4	Mus musculus	110-114
16616333-0	2006	A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.	Proline	31-38	transformation related protein 53, pseudogene	Mus musculus	115-118
16616333-2	2006	We generated a mouse encoding p53 lacking the proline-rich domain (p53DeltaP).	Proline	46-53	transformation related protein 53, pseudogene	Mus musculus	30-33
16384863-5	2006	In this study we found that AGRP is processed intracellularly after Arg(79)-Glu(80)-Pro(81)-Arg(82).	Proline	84-87	agouti related neuropeptide	Rattus norvegicus	28-32
16594917-0	2006	Inhibition of matrix metalloproteinase-2 secretion and invasion by human ovarian cancer cell line SK-OV-3 with lysine, proline, arginine, ascorbic acid and green tea extract.	Proline	119-126	matrix metallopeptidase 2	Homo sapiens	14-40
16464956-0	2006	HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites.	Proline	68-75	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
16464956-3	2006	The HSP90 inhibitors reduced levels of tau phosphorylated at proline-directed Ser/Thr sites (pS202/T205, pS396/S404) and conformationally altered (MC-1) tau species, an epitope that is immeasurable by standard Western blot techniques.	Proline	61-68	heat shock protein 90 alpha family class A member 1	Homo sapiens	4-9
16571786-4	2006	We find that Vpr coimmunoprecipitates with CypA and that this interaction is disrupted by substitution of proline-35 of Vpr as well as incubation with the CypA inhibitor cyclosporine A (CsA).	Proline	106-113	peptidylprolyl isomerase A	Homo sapiens	43-47
16830502-1	2006	The chromatographic behaviour of a poly-L-proline-derived chiral stationary phase (CSP) is compared to the corresponding single proline-derived CSP.	Proline	42-49	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	83-86
16394625-2	2006	Pin1 is a highly conserved enzyme that isomerizes only the phosphorylated Ser/Thr-Pro bonds in certain proteins, thereby inducing conformational changes.	Proline	82-85	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
16571786-4	2006	We find that Vpr coimmunoprecipitates with CypA and that this interaction is disrupted by substitution of proline-35 of Vpr as well as incubation with the CypA inhibitor cyclosporine A (CsA).	Proline	106-113	peptidylprolyl isomerase A	Homo sapiens	155-159
16387743-5	2006	The results demonstrated that HK-2 cells stably transfected with MT-3 that had been modified by converting the 2 prolines at amino acid positions 7 and 9 to threonines was no longer active in promoting necrotic cell death at lower levels of Cd(+2) exposure.	Proline	113-121	metallothionein 3	Homo sapiens	65-69
16499995-11	2006	Somatic TP53 mutations were found in 62 out of 240 NSCLC patients (26%), more frequently in Pro carriers (31%) than in Arg homozygotes (20%, p = 0.06).	Proline	92-95	tumor protein p53	Homo sapiens	8-12
16758882-8	2006	Different simplest proline and hydroxyproline fragments of glyprolines are revealed in various type of collagen: GP, GHyp, PG, PPG, PGP, PHypG., GPHyp, GPP, GPG, GHypP, HypGP.	Proline	19-26	serglycin	Homo sapiens	127-130
16758882-8	2006	Different simplest proline and hydroxyproline fragments of glyprolines are revealed in various type of collagen: GP, GHyp, PG, PPG, PGP, PHypG., GPHyp, GPP, GPG, GHypP, HypGP.	Proline	19-26	phosphoglycolate phosphatase	Homo sapiens	132-135
16554819-3	2006	Phosphorylated Ser/Thr-Pro motifs in peptides can exist in cis or trans conformations, the conversion of which is catalysed by the Pin1 prolyl isomerase.	Proline	23-26	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	131-135
16549777-5	2006	We found that, although the alpha-chain gene sequences of the siblings were normal, the beta(2)m genes contained a single nucleotide transversion that would mutate a conserved alanine to proline at the midpoint of the signal sequence.	Proline	187-194	alpha-2-macroglobulin	Homo sapiens	88-96
16282344-3	2006	In addition to its receptor-interacting and cell death-inducing extracellular domain, FasL has a well-conserved intracellular portion with a proline-rich SH3 domain-binding site probably involved in non-apoptotic functions.	Proline	141-148	Fas ligand	Homo sapiens	86-90
16442502-2	2006	MKK7 activates JNK via phosphorylation of a threonine and tyrosine residue in a Thr-Pro-Tyr motif within kinase subdomain VIII.	Proline	84-87	mitogen-activated protein kinase kinase 7	Homo sapiens	0-4
16442502-2	2006	MKK7 activates JNK via phosphorylation of a threonine and tyrosine residue in a Thr-Pro-Tyr motif within kinase subdomain VIII.	Proline	84-87	mitogen-activated protein kinase 8	Homo sapiens	15-18
17962790-0	2006	L-proline catalyzed Michael additions of thiophenols to alpha,beta-unsaturated compounds, particularly alpha-enones, in the ionic liquid [bmim]PF6.	Proline	0-9	sperm associated antigen 17	Homo sapiens	143-146
16410248-4	2006	With the P(2)-Pro(1) library, FAP preferred Ile, Pro, or Arg at the P(2) residue; however, DPP-4 showed broad reactivity against this library, precluding selectivity.	Proline	14-17	fibroblast activation protein alpha	Homo sapiens	30-33
16470701-1	2006	Encoded by the peptidase D (PEPD) gene located at 19q12-q13.11, prolidase is a ubiquitous cytosolic enzyme that catalyzes hydrolysis of oligopeptides with a C-terminal proline or hydroxyproline.	Proline	168-175	peptidase D	Homo sapiens	15-26
16470701-1	2006	Encoded by the peptidase D (PEPD) gene located at 19q12-q13.11, prolidase is a ubiquitous cytosolic enzyme that catalyzes hydrolysis of oligopeptides with a C-terminal proline or hydroxyproline.	Proline	168-175	peptidase D	Homo sapiens	28-32
16470701-1	2006	Encoded by the peptidase D (PEPD) gene located at 19q12-q13.11, prolidase is a ubiquitous cytosolic enzyme that catalyzes hydrolysis of oligopeptides with a C-terminal proline or hydroxyproline.	Proline	168-175	peptidase D	Homo sapiens	64-73
16376544-1	2006	The co-crystal structure of beta-phenethylamine fragment inhibitor 5 bound to DPP-IV revealed that the phenyl ring occupied the proline pocket of the enzyme.	Proline	128-135	dipeptidyl peptidase 4	Homo sapiens	78-84
16326905-8	2006	Mutation of the Pro or Gly of the Pro-Ala-Gly motif to Ala abolished KCNQ1 function and introduction of Gly in front of the Ala-mutations partially recovered channel function, suggesting that flexibility at the PAG is important for channel activation.	Proline	16-19	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	69-74
16339921-8	2006	However, titin exon transcript studies revealed up-regulation of seven exons, which code for spring elements in the elastic segment rich in proline, glutamate, valine, and lysine.	Proline	140-147	titin	Homo sapiens	9-14
16520382-4	2006	The NH(2)-terminal proline-rich collagen homology 2 (CH2) domain of p66shc associates with full-length grb2 in vitro via the COOH-terminal src homology 3 (C-SH3) domain of grb2.	Proline	19-26	growth factor receptor bound protein 2	Homo sapiens	103-107
16520382-4	2006	The NH(2)-terminal proline-rich collagen homology 2 (CH2) domain of p66shc associates with full-length grb2 in vitro via the COOH-terminal src homology 3 (C-SH3) domain of grb2.	Proline	19-26	growth factor receptor bound protein 2	Homo sapiens	172-176
16520382-6	2006	The CH2 domain competes with the proline-rich COOH-terminal region of sos1 for the C-SH3 domain of grb2.	Proline	33-40	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	70-74
16520382-6	2006	The CH2 domain competes with the proline-rich COOH-terminal region of sos1 for the C-SH3 domain of grb2.	Proline	33-40	growth factor receptor bound protein 2	Homo sapiens	99-103
16494447-3	2006	In contrast, (S)-proline-catalyzed reactions give mainly syn-products with high enantioselectivities.	Proline	13-24	synemin	Homo sapiens	57-60
16494447-4	2006	Computational studies reveal that the energetic preference between the transition structures involving the s-cis-enamine and the s-trans-enamine is smaller for the pipecolic acid as compared to proline, yielding the (2S,3R)-anti and the (2S,3S)-syn Mannich product in nearly equal amounts.	Proline	194-201	synemin	Homo sapiens	245-248
16449235-0	2006	Impaired helix 12 dynamics due to proline 892 substitutions in the androgen receptor are associated with complete androgen insensitivity.	Proline	34-41	androgen receptor	Homo sapiens	67-84
16449235-4	2006	In this study, we investigated the role of the conserved proline 892 of the androgen receptor (AR) in directing the dynamic location and orientation of the AR-H12.	Proline	57-64	androgen receptor	Homo sapiens	76-93
16449235-4	2006	In this study, we investigated the role of the conserved proline 892 of the androgen receptor (AR) in directing the dynamic location and orientation of the AR-H12.	Proline	57-64	androgen receptor	Homo sapiens	95-97
16449235-4	2006	In this study, we investigated the role of the conserved proline 892 of the androgen receptor (AR) in directing the dynamic location and orientation of the AR-H12.	Proline	57-64	ras homolog family member A	Homo sapiens	156-162
16449235-12	2006	Proline at this position may be critical for H12 dynamics not only in the AR, but also in other nuclear receptors where this proline is conserved.	Proline	0-7	androgen receptor	Homo sapiens	74-76
16303763-1	2006	A predicted alanine to proline substitution in Stat5b that results in profound short stature, growth hormone insensitivity, and immunodeficiency represents the first natural mutation of this transcription factor in a human.	Proline	23-30	signal transducer and activator of transcription 5B	Homo sapiens	47-53
16303763-1	2006	A predicted alanine to proline substitution in Stat5b that results in profound short stature, growth hormone insensitivity, and immunodeficiency represents the first natural mutation of this transcription factor in a human.	Proline	23-30	growth hormone 1	Homo sapiens	94-108
16480718-3	2006	FAP required substrates with Pro at P(1) and Gly or d-amino acids at P(2) and preferred small, uncharged amino acids at P(3), but tolerated most amino acids at P(4), P(1)(") and P(2)(").	Proline	29-32	fibroblast activation protein alpha	Homo sapiens	0-3
16339921-12	2006	Our results suggest that alternative splicing of the titin gene, resulting in increased length of the elastic segment rich in proline, glutamate, valine, and lysine, is involved.	Proline	126-133	titin	Homo sapiens	53-58
16492054-5	2006	In peptide 2, the antiparallel registry is maintained, with the formation of a (D)Pro-(L)Pro-(D)Ala loop, stabilized by a 5--&gt;1 hydrogen bond between Val3 CO and Leu7 NH groups (C(13), alpha-turn) and a 3--&gt;1 hydrogen bond between (D)Pro4 CO and (d)Ala6 NH groups (C(7), gamma-turn).	Proline	82-85	beta-1,3-glucuronyltransferase 1	Homo sapiens	165-169
16321524-1	2006	Dipeptidyl peptidase IV is a clinically validated target for type-2 diabetes and belongs to a family of peptidases with a quite unique post-proline cleavage specificity.	Proline	140-147	dipeptidyl peptidase 4	Homo sapiens	0-23
16483316-5	2006	Vinexin beta interacts with the proline-rich region of WAVE2 through the first and second SH3 domains of vinexin beta.	Proline	32-39	sorbin and SH3 domain containing 3	Homo sapiens	0-7
16483316-5	2006	Vinexin beta interacts with the proline-rich region of WAVE2 through the first and second SH3 domains of vinexin beta.	Proline	32-39	WASP family member 2	Homo sapiens	55-60
16483316-5	2006	Vinexin beta interacts with the proline-rich region of WAVE2 through the first and second SH3 domains of vinexin beta.	Proline	32-39	sorbin and SH3 domain containing 3	Homo sapiens	105-112
16325371-3	2006	SMCP can now be reliably identified by its tripartite structure including a short amino-terminal segment; a central segment containing short tandem repeats rich in cysteine, proline, glutamine, and lysine; and a C-terminal segment containing no repeats, few cysteines, and a C-terminal lysine.	Proline	174-181	sperm mitochondria associated cysteine rich protein	Homo sapiens	0-4
16495487-8	2006	Sec31B-F closely resembles Sec31p and Sec31A, with canonical WD repeats in an N-terminal domain that binds Sec13 and a proline-rich C-terminal region that presumably binds Sec23/24.	Proline	119-126	SEC31 homolog B, COPII coat complex component	Homo sapiens	0-6
16222711-6	2006	Deletion of the first proline rich region within the N-terminus precluded recruitment of PI3K-C2beta to activated EGFR.	Proline	22-29	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	Homo sapiens	89-100
16222711-6	2006	Deletion of the first proline rich region within the N-terminus precluded recruitment of PI3K-C2beta to activated EGFR.	Proline	22-29	epidermal growth factor receptor	Homo sapiens	114-118
16014698-9	2006	We identified a missense mutation, c.1322T>C, causing substitution of a leucine with a proline at amino acid residue 441 within the active signalling domain of GDF5.	Proline	87-94	growth differentiation factor 5	Homo sapiens	160-164
16495487-9	2006	The Sec31B-T group (molecular mass 52,983 Da) contains a preserved WD-repeat domain but lacks the C-terminal proline-rich region.	Proline	109-116	SEC31 homolog B, COPII coat complex component	Homo sapiens	4-10
16474160-4	2006	When the 2F5 epitope was inserted in the proline-rich region of MLV Env surface protein (SU), 2F5 blocked cell fusion and virus infection, whereas MLV with a hemagglutinin (HA) epitope at the same position was not neutralized by anti-HA, even though the antibodies bound their respective Envs on the surface of infected cells and viruses equally well.	Proline	41-48	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	68-71
16465388-4	2006	We identified the transactivation domain of Osterix, which contains high proline and glycine residues and has an activation property in mammalian and yeast cells.	Proline	73-80	Sp7 transcription factor	Homo sapiens	44-51
16498444-3	2006	The identification of a new family of proteins, known as ASPPs (ankyrin-repeat-, SH3-domain- and proline-rich-region-containing proteins), has led to the discovery of a novel mechanism that selectively regulates the apoptotic function, but not the cell-cycle-arrest function, of p53, and gives an insight into how p53 responds to different stress signals.	Proline	97-104	tumor protein p53	Homo sapiens	279-282
16646561-2	2006	The codon 72 polymorphism on exon 4 in the p53 gene produces variant proteins with either arginine (Arg) or proline (Pro), and is associated with an increased susceptibility of cancers of the lung, esophagus, breast, cervix and nasopharynx on a genetic basis.	Proline	108-115	tumor protein p53	Homo sapiens	43-46
16646561-2	2006	The codon 72 polymorphism on exon 4 in the p53 gene produces variant proteins with either arginine (Arg) or proline (Pro), and is associated with an increased susceptibility of cancers of the lung, esophagus, breast, cervix and nasopharynx on a genetic basis.	Proline	117-120	tumor protein p53	Homo sapiens	43-46
16498444-3	2006	The identification of a new family of proteins, known as ASPPs (ankyrin-repeat-, SH3-domain- and proline-rich-region-containing proteins), has led to the discovery of a novel mechanism that selectively regulates the apoptotic function, but not the cell-cycle-arrest function, of p53, and gives an insight into how p53 responds to different stress signals.	Proline	97-104	tumor protein p53	Homo sapiens	314-317
16492808-3	2006	In this study, we show that the Rho GTPase Rac1, via a proline stretch in its COOH terminus, binds directly to the SH3 domain of the Cdc42/Rac activator beta-Pix (p21-activated kinase [Pak]-interacting exchange factor).	Proline	55-62	Rac family small GTPase 1	Homo sapiens	43-47
16413612-8	2006	A proline (Pro) to leucine (Leu) substitution at codon 197 (Pro197Leu) in the GPX1 gene was genotyped.	Proline	2-9	glutathione peroxidase 1	Homo sapiens	78-82
16413612-8	2006	A proline (Pro) to leucine (Leu) substitution at codon 197 (Pro197Leu) in the GPX1 gene was genotyped.	Proline	11-14	glutathione peroxidase 1	Homo sapiens	78-82
16413928-5	2006	Site-directed mutagenesis studies indicated that Pro-236 of the TP-i3 was involved in the binding to the 14-3-3zeta.	Proline	49-52	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	105-115
16501221-4	2006	In the case of RICK-CARD, the time constants of the slow refolding phases are consistent with proline isomerism.	Proline	94-101	receptor interacting serine/threonine kinase 2	Homo sapiens	15-24
16501221-5	2006	RICK-CARD contains three prolines, P47 in turn 3, and P85 and P87.	Proline	25-33	receptor interacting serine/threonine kinase 2	Homo sapiens	0-4
16501221-7	2006	To examine the role of the prolines in the complex folding kinetics of RICK-CARD, we generated seven proline-to-alanine mutants, including three single mutants, three double mutants, and one triple mutant.	Proline	27-34	receptor interacting serine/threonine kinase 2	Homo sapiens	71-75
16492808-3	2006	In this study, we show that the Rho GTPase Rac1, via a proline stretch in its COOH terminus, binds directly to the SH3 domain of the Cdc42/Rac activator beta-Pix (p21-activated kinase [Pak]-interacting exchange factor).	Proline	55-62	cell division cycle 42	Homo sapiens	133-138
16318864-11	2006	There was also a higher incidence of, but without reaching a statistical significance, p53 mutation in patients with p53 overexpression (OR[95% CI]: 2.18 [0.52-9.6]) and codon 72 Arg/Arg genotype (OR [95% CI] of 0.8 [0.13-4.2], comparing genotypes of Pro/Pro and Arg/Pro with Arg/Arg).	Proline	251-254	tumor protein p53	Homo sapiens	87-90
16492808-3	2006	In this study, we show that the Rho GTPase Rac1, via a proline stretch in its COOH terminus, binds directly to the SH3 domain of the Cdc42/Rac activator beta-Pix (p21-activated kinase [Pak]-interacting exchange factor).	Proline	55-62	AKT serine/threonine kinase 1	Homo sapiens	43-46
16318864-11	2006	There was also a higher incidence of, but without reaching a statistical significance, p53 mutation in patients with p53 overexpression (OR[95% CI]: 2.18 [0.52-9.6]) and codon 72 Arg/Arg genotype (OR [95% CI] of 0.8 [0.13-4.2], comparing genotypes of Pro/Pro and Arg/Pro with Arg/Arg).	Proline	255-258	tumor protein p53	Homo sapiens	87-90
16456541-4	2006	IEX-1 binds to B56 subunits and pERK independently, enhances B56 phosphorylation by ERK at a conserved Ser/Pro site in this complex and triggers dissociation from the catalytic subunit.	Proline	107-110	immediate early response 3	Homo sapiens	0-5
16318864-11	2006	There was also a higher incidence of, but without reaching a statistical significance, p53 mutation in patients with p53 overexpression (OR[95% CI]: 2.18 [0.52-9.6]) and codon 72 Arg/Arg genotype (OR [95% CI] of 0.8 [0.13-4.2], comparing genotypes of Pro/Pro and Arg/Pro with Arg/Arg).	Proline	255-258	tumor protein p53	Homo sapiens	87-90
16492808-3	2006	In this study, we show that the Rho GTPase Rac1, via a proline stretch in its COOH terminus, binds directly to the SH3 domain of the Cdc42/Rac activator beta-Pix (p21-activated kinase [Pak]-interacting exchange factor).	Proline	55-62	Rho guanine nucleotide exchange factor 7	Homo sapiens	153-161
16456541-4	2006	IEX-1 binds to B56 subunits and pERK independently, enhances B56 phosphorylation by ERK at a conserved Ser/Pro site in this complex and triggers dissociation from the catalytic subunit.	Proline	107-110	mitogen-activated protein kinase 1	Homo sapiens	33-36
16434477-4	2006	This report shows that APRO4 associates with Src via its C-terminal proline-rich domain, and downregulates Src kinase activity.	Proline	68-75	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	45-48
16259621-10	2006	Interestingly, degradation of an intrinsically unstable mutant form of TS, containing a Pro--&gt;Leu substitution at residue 303, is directed by C-terminal, rather than N-terminal, sequences.	Proline	88-91	thymidylate synthetase	Homo sapiens	71-73
16434477-4	2006	This report shows that APRO4 associates with Src via its C-terminal proline-rich domain, and downregulates Src kinase activity.	Proline	68-75	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	107-110
16326715-5	2006	We subsequently determined the solution structure of the p47phox tandem SH3 domains complexed with the proline-rich peptide of p22phox using NMR spectroscopy.	Proline	103-110	neutrophil cytosolic factor 1	Homo sapiens	57-64
16489009-2	2006	We have shown that the antiangiogenic effect of HRGP is dependent on its histidine/proline-rich domain, which needs to be released from the mother protein to exert its effects.	Proline	83-90	histidine-rich glycoprotein	Mus musculus	48-52
16326715-4	2006	Using NMR titration, we first identified the proline-rich region of p22phox that is essential for binding to the tandem SH3 domains of p47phox.	Proline	45-52	neutrophil cytosolic factor 1	Homo sapiens	135-142
16456002-2	2006	SLP-76 has three functional modules: an acidic domain with three key tyrosines, a central proline-rich domain, and a C-terminal Src homology 2 domain.	Proline	90-97	lymphocyte cytosolic protein 2	Homo sapiens	0-6
16326715-0	2006	NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide.	Proline	104-111	neutrophil cytosolic factor 1	Homo sapiens	63-70
16326715-5	2006	We subsequently determined the solution structure of the p47phox tandem SH3 domains complexed with the proline-rich peptide of p22phox using NMR spectroscopy.	Proline	103-110	cytochrome b-245 alpha chain	Homo sapiens	127-134
16326715-0	2006	NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide.	Proline	104-111	cytochrome b-245 alpha chain	Homo sapiens	88-95
16326715-3	2006	When phagocytes are activated, the cytosolic components of the NADPH oxidase translocate to flavocytochrome b558 due to binding of the tandem Src homology 3 (SH3) domains of p47phox to a proline-rich region in p22phox, a subunit of flavocytochrome b558.	Proline	187-194	neutrophil cytosolic factor 1	Homo sapiens	174-181
16326715-4	2006	Using NMR titration, we first identified the proline-rich region of p22phox that is essential for binding to the tandem SH3 domains of p47phox.	Proline	45-52	cytochrome b-245 alpha chain	Homo sapiens	68-75
16467116-10	2006	Furthermore, proline-, glutamic acid-, leucine-rich protein 1, an ER coactivator involved in both genomic and nongenomic signaling pathways, is activated by epidermal growth factor receptor and plays a prominent role in resistance to tamoxifen.	Proline	13-20	epidermal growth factor receptor	Homo sapiens	157-189
16319076-3	2006	Here we show that profilin 2 associates with dynamin 1 via the C-terminal proline-rich domain of dynamin and thereby competes with the binding of SH3 ligands such as endophilin, amphiphysin, and Grb2, thus interfering with the assembly of the endocytic machinery.	Proline	74-81	profilin 2	Mus musculus	18-28
16319076-3	2006	Here we show that profilin 2 associates with dynamin 1 via the C-terminal proline-rich domain of dynamin and thereby competes with the binding of SH3 ligands such as endophilin, amphiphysin, and Grb2, thus interfering with the assembly of the endocytic machinery.	Proline	74-81	dynamin 1	Mus musculus	45-54
16506117-4	2006	The exons of the patient"s SF-1 gene were sequenced, and despite identifying a single nucleotide polymorphism that preserves proline at position 125 of SF-1, none of the previously identified mutations were detected in our samples.	Proline	125-132	splicing factor 1	Homo sapiens	27-31
16506117-4	2006	The exons of the patient"s SF-1 gene were sequenced, and despite identifying a single nucleotide polymorphism that preserves proline at position 125 of SF-1, none of the previously identified mutations were detected in our samples.	Proline	125-132	splicing factor 1	Homo sapiens	152-156
16153625-7	2006	Substitution of residue 72 from a helix former leucine to a helix breaker, proline, is predicted to change the secondary structure of the C-terminal helix and subsequently alter the interaction between apo C-II and LPL.	Proline	75-82	apolipoprotein C2	Homo sapiens	202-210
16153625-7	2006	Substitution of residue 72 from a helix former leucine to a helix breaker, proline, is predicted to change the secondary structure of the C-terminal helix and subsequently alter the interaction between apo C-II and LPL.	Proline	75-82	lipoprotein lipase	Homo sapiens	215-218
16455491-0	2006	Allosteric regulation of Hsp70 chaperones by a proline switch.	Proline	47-54	heat shock protein family A (Hsp70) member 4	Homo sapiens	25-30
16455491-4	2006	The conformation of the proline, acting through an invariant arginine as relay, determines and stabilizes the opened and closed conformation of the substrate binding domain and thereby regulates the chaperone activity of Hsp70.	Proline	24-31	heat shock protein family A (Hsp70) member 4	Homo sapiens	221-226
16385466-9	2006	The proline at position 412 is conserved between species and is predicted by molecular modeling to reduce the DNA-binding properties of ZNF674.	Proline	4-11	zinc finger protein 674	Homo sapiens	136-142
16139409-2	2006	In the presence of oxygen and iron, proline residues in two degradation domains are modified by HIF-1-prolyl hydroxylases (PHDs), resulting in ubiquitination and degradation of HIF-1alpha.	Proline	36-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	177-187
16139409-11	2006	The oxygen-dependent HIF-1alpha regulation requiring both proline hydroxylation and lysine acetylation may be more complicated than the iron-dependent regulation requiring only proline hydroxylation.	Proline	58-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-31
16139409-11	2006	The oxygen-dependent HIF-1alpha regulation requiring both proline hydroxylation and lysine acetylation may be more complicated than the iron-dependent regulation requiring only proline hydroxylation.	Proline	177-184	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-31
16440369-4	2006	This C/EBPalpha-HNF6 transcriptional synergy required both the N-terminal HNF6 polyhistidine and serine/threonine/proline box sequences, as well as the C/EBPalpha AD1/AD2 sequences, the latter of which are known to recruit the CREB binding protein (CBP) transcriptional coactivator.	Proline	114-121	CCAAT enhancer binding protein alpha	Homo sapiens	5-20
16380538-5	2006	[3H]-thymidine and [3H]-proline incorporation by cardiac fibroblasts treated with Ang II was enhanced when the cells were pretreated with AICAR.	Proline	24-31	angiotensinogen	Rattus norvegicus	82-88
16405505-8	2006	Mutation of this conserved proline in TPH1 (P403R) also resulted in an enzyme with significantly lower activity than the wild-type enzyme.	Proline	27-34	tryptophan hydroxylase 1	Mus musculus	38-42
16405505-12	2006	The conserved proline in TPH (residue 447 in TPH2 and 403 in TPH1) plays an important role in enzyme function by regulating V(max) of the catalytic reaction.	Proline	14-21	tryptophan hydroxylase 1	Mus musculus	25-28
16405505-12	2006	The conserved proline in TPH (residue 447 in TPH2 and 403 in TPH1) plays an important role in enzyme function by regulating V(max) of the catalytic reaction.	Proline	14-21	tryptophan hydroxylase 2	Mus musculus	45-49
16405505-12	2006	The conserved proline in TPH (residue 447 in TPH2 and 403 in TPH1) plays an important role in enzyme function by regulating V(max) of the catalytic reaction.	Proline	14-21	tryptophan hydroxylase 1	Mus musculus	61-65
16607040-3	2006	The putative cytoplasmic N-terminus of mRECS1 has a high content of proline (23%) and glycine (12%) residues, contains one PPXY motif, multiple PXXP motifs and one overlapping P(T/S)AP and PPXY motif (P(T/S)APPXY).	Proline	68-75	transmembrane BAX inhibitor motif containing 1	Mus musculus	39-45
16433496-2	2006	Based on principles gained from the study of (S)-proline-catalyzed Mannich-type reactions that afford enantiomerically enriched syn-products, (3R,5R)-5-methyl-3-pyrrolidinecarboxylic acid (RR35) has been designed to catalyze the direct enantioselective anti-selective Mannich-type reactions.	Proline	45-56	synemin	Homo sapiens	128-131
16405500-10	2006	Moreover, interaction of both mutant and wild-type huntingtin exon 1 fragments with brain lipids caused bilayer perturbation, mediated through a proline-rich region adjacent to the polyglutamines.	Proline	145-152	huntingtin	Mus musculus	51-61
16440369-4	2006	This C/EBPalpha-HNF6 transcriptional synergy required both the N-terminal HNF6 polyhistidine and serine/threonine/proline box sequences, as well as the C/EBPalpha AD1/AD2 sequences, the latter of which are known to recruit the CREB binding protein (CBP) transcriptional coactivator.	Proline	114-121	one cut homeobox 1	Homo sapiens	16-20
16440369-4	2006	This C/EBPalpha-HNF6 transcriptional synergy required both the N-terminal HNF6 polyhistidine and serine/threonine/proline box sequences, as well as the C/EBPalpha AD1/AD2 sequences, the latter of which are known to recruit the CREB binding protein (CBP) transcriptional coactivator.	Proline	114-121	CCAAT enhancer binding protein alpha	Homo sapiens	5-15
16428455-0	2006	The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo.	Proline	4-11	cyclin-dependent kinase 2	Mus musculus	27-31
16428455-0	2006	The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo.	Proline	4-11	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	59-69
16449657-2	2006	Certain phosphorylated Ser/Thr-Pro motifs can exist in two distinct conformations whose conversion in certain proteins is catalyzed specifically by the prolyl isomerase Pin1.	Proline	31-34	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	169-173
16624024-11	2006	After KA kindling, KD-fed animals [(189.38 +/- 40.03)/mg pro] had significantly higher GluR(5) expression in hippocampus than control diet-fed animals [(128.79 +/- 46.51)/mg pro] although their GluR(5) mRNA was the same.	Proline	57-60	glutamate ionotropic receptor kainate type subunit 1	Rattus norvegicus	87-94
16426656-4	2006	Proline incorporation occurs mainly in the growing centers, and is more specifically associated with beta-keratin synthesis.	Proline	0-7	keratin	Gallus gallus	106-113
16407116-2	2006	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase implicated in the development and disease of the mammalian nervous system.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
16154213-2	2006	It exhibits a dipeptidyl-peptidase activity (DPP-IV) that cleaves the penultimate proline from the N-terminus of polypeptides, thereby regulating their activity and concentration.	Proline	82-89	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	14-34
16154213-2	2006	It exhibits a dipeptidyl-peptidase activity (DPP-IV) that cleaves the penultimate proline from the N-terminus of polypeptides, thereby regulating their activity and concentration.	Proline	82-89	dipeptidylpeptidase 4	Mus musculus	45-51
16176182-5	2006	Drosophila PHD has a low substrate specificity and hydroxylates key proline residues in the ODD (oxygen-dependent degradation) domains of human HIF-1alpha and Similar, the Drosophila homologue of HIF-1alpha.	Proline	68-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-154
16176182-5	2006	Drosophila PHD has a low substrate specificity and hydroxylates key proline residues in the ODD (oxygen-dependent degradation) domains of human HIF-1alpha and Similar, the Drosophila homologue of HIF-1alpha.	Proline	68-75	similar	Drosophila melanogaster	196-206
16401076-5	2006	The mtMCM structure was successfully used to analyze a Saccharomyces cerevisiae MCM5 mutant, called BOB1, which contains a single residue change from Pro to Leu and bypasses a kinase normally required for initiation of DNA replication.	Proline	150-153	MCM DNA helicase complex subunit MCM5	Saccharomyces cerevisiae S288C	80-84
16401076-5	2006	The mtMCM structure was successfully used to analyze a Saccharomyces cerevisiae MCM5 mutant, called BOB1, which contains a single residue change from Pro to Leu and bypasses a kinase normally required for initiation of DNA replication.	Proline	150-153	MCM DNA helicase complex subunit MCM5	Saccharomyces cerevisiae S288C	100-104
16407116-2	2006	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase implicated in the development and disease of the mammalian nervous system.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
16393996-5	2006	At the protein level, DC-SCRIPT consists of a proline-rich region, 11 C2H2-type zinc fingers, and an acidic region.	Proline	46-53	zinc finger protein 366	Homo sapiens	22-31
16179375-6	2006	Our data indicate that SHIP-2 must contain both the N-terminal SH2 domain and the C-terminal proline-rich domain to mediate its inhibitory effect.	Proline	93-100	inositol polyphosphate phosphatase-like 1	Mus musculus	23-29
16392822-2	2006	Most known DPP-IV inhibitors often resemble the dipeptide cleavage products, with a proline mimic at the P1 site.	Proline	84-91	dipeptidylpeptidase 4	Rattus norvegicus	11-17
16291749-5	2006	This region of KCC2 is rich in prolines, serines, and charged residues and encompasses two predicted PEST sequences.	Proline	31-39	solute carrier family 12 member 5	Homo sapiens	15-19
16303136-0	2006	Destabilization of human IAPP amyloid fibrils by proline mutations outside of the putative amyloidogenic domain: is there a critical amyloidogenic domain in human IAPP?	Proline	49-56	islet amyloid polypeptide	Homo sapiens	25-29
16303136-6	2006	The different behavior of human and rat IAPP could be due to differences in the 20-29 region or due simply to the fact that multiple proline residues destabilize amyloid fibrils.	Proline	133-140	islet amyloid polypeptide	Rattus norvegicus	40-44
16303136-8	2006	We designed a variant of the amyloidogenic 8-37 region of human IAPP (hIAPP(8-37) 3xP) with proline substitutions at positions 17, 19 and 30.	Proline	92-99	islet amyloid polypeptide	Homo sapiens	64-68
16214863-2	2006	The results of a previous study indicated that the N-terminal segment of SP-B, comprising residues 1-9, is specifically required for surface activity, and suggested that prolines 2, 4, and 6 as well as tryptophan 9, may constitute essential structural motifs for protein function.	Proline	170-178	surfactant protein B	Homo sapiens	73-77
16186805-4	2006	The 44 kDa Pim-1 contains the proline-rich motif at the N-terminus and directly binds to the SH3 domain of tyrosine kinase Etk.	Proline	30-37	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	11-16
16186805-4	2006	The 44 kDa Pim-1 contains the proline-rich motif at the N-terminus and directly binds to the SH3 domain of tyrosine kinase Etk.	Proline	30-37	BMX non-receptor tyrosine kinase	Homo sapiens	123-126
16388667-0	2006	Proline-catalyzed, asymmetric mannich reactions in the synthesis of a DPP-IV inhibitor.	Proline	0-7	dipeptidyl peptidase 4	Homo sapiens	70-76
16699611-4	2006	AIM: To investigate the possible association between p53 arginine/72 proline polymorphism and susceptibility to colorectal cancer.	Proline	69-76	tumor protein p53	Homo sapiens	53-56
16307728-3	2006	The N-terminus of BARHL1 protein presents two FIL domains and an acidic domain rich in serine/threonine and proline, while the C-terminus contains a canonical proline-rich domain.	Proline	108-115	BarH like homeobox 1	Homo sapiens	18-24
16307728-3	2006	The N-terminus of BARHL1 protein presents two FIL domains and an acidic domain rich in serine/threonine and proline, while the C-terminus contains a canonical proline-rich domain.	Proline	159-166	BarH like homeobox 1	Homo sapiens	18-24
17113725-1	2006	BACKGROUND: A common Arg/Pro polymorphism at codon 72 of the TP53 gene has been investigated as a risk factor for cancer in different populations.	Proline	25-28	tumor protein p53	Homo sapiens	61-65
16122996-10	2006	Mutation analysis, utilizing direct sequencing, revealed a single base pair change c.293T --&gt; C in the pstpip2 gene resulting in a highly conserved leucine at amino acid 98 being replaced by a proline (L98P).	Proline	196-203	proline-serine-threonine phosphatase-interacting protein 2	Mus musculus	106-113
16923618-4	2006	METHODS: The TNF mutant (recombinant mutated human TNF; rmhTNF) was prepared by protein engineering in which amino acids Pro, Ser and Asp at positions 8, 9 and 10 of TNF-alpha were substituted by Arg, Lys and Arg, and C terminal Leu157 was substituted by Phe, along with deletion of the first seven N-terminal amino acids.	Proline	121-124	tumor necrosis factor	Homo sapiens	13-16
16317718-1	2006	Profilins are actin binding proteins, which also interact with polyphosphoinositides and proline-rich ligands.	Proline	89-96	Profilin-1	Caenorhabditis elegans	0-9
16923618-4	2006	METHODS: The TNF mutant (recombinant mutated human TNF; rmhTNF) was prepared by protein engineering in which amino acids Pro, Ser and Asp at positions 8, 9 and 10 of TNF-alpha were substituted by Arg, Lys and Arg, and C terminal Leu157 was substituted by Phe, along with deletion of the first seven N-terminal amino acids.	Proline	121-124	tumor necrosis factor	Homo sapiens	51-54
17192673-7	2006	PRiMAcDNA encodes a single-pass approximately 20-kDa type-I transmembrane protein and, similar to that of ColQ, contains a short PRAD (proline-rich attachment domain) that is able to organize AChE catalytic subunits into tetramers and anchor the enzyme at the surface of neuron and muscle (Massoulie, 2002).	Proline	135-142	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	106-110
16400178-8	2006	Also consistent with our observations of the DA Ras mutant, high levels of reactive oxygen species (ROS) were observed in the DA Cdc42 mutant, and proline restored the wild-type phenotype.	Proline	147-154	Rho family GTPase CDC42	Saccharomyces cerevisiae S288C	129-134
16697285-1	2006	The old concept that the lacrimal gland is only a serous gland has been superseded by the finding that lacrimal acinar cells are able to produce mucins--high-molecular-weight proteins--the major mass being carbohydrates with the common feature of tandem repeats of amino acids rich in serine, threonine, and proline in the central domain of the mucin core peptide.	Proline	308-315	LOC100508689	Homo sapiens	145-150
16168468-3	2006	RESULTS: When p53 codon 72 genotype was classified into two subgroups of Arg/Arg and Arg/Pro + Pro/Pro, the Arg/Arg genotype was associated with an increased risk for the development of endometrial cancer (OR = 1.86, 95% CI = 1.06 to 3.26) compared with the Arg/Pro + Pro/Pro genotype (P = 0.0301).	Proline	89-92	tumor protein p53	Homo sapiens	14-17
16339784-6	2006	Quantification of low water potential-induced ABA and Pro accumulation in five ABA-insensitive mutants, abi1-1, abi2-1, abi3, abi4, and abi5, revealed that abi4 had increased Pro accumulation at low water potential, but a reduced response to exogenous ABA.	Proline	54-57	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	156-160
16339784-6	2006	Quantification of low water potential-induced ABA and Pro accumulation in five ABA-insensitive mutants, abi1-1, abi2-1, abi3, abi4, and abi5, revealed that abi4 had increased Pro accumulation at low water potential, but a reduced response to exogenous ABA.	Proline	175-178	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	156-160
16397066-5	2006	RESULTS: A 262C&gt;A transition that resulted in the replacement of proline by glutamine (P88Q) in the coding region of connexin50 (Cx50) was identified.	Proline	68-75	gap junction protein alpha 8 L homeolog	Xenopus laevis	120-130
16397066-5	2006	RESULTS: A 262C&gt;A transition that resulted in the replacement of proline by glutamine (P88Q) in the coding region of connexin50 (Cx50) was identified.	Proline	68-75	gap junction protein alpha 8 L homeolog	Xenopus laevis	132-136
17192673-7	2006	PRiMAcDNA encodes a single-pass approximately 20-kDa type-I transmembrane protein and, similar to that of ColQ, contains a short PRAD (proline-rich attachment domain) that is able to organize AChE catalytic subunits into tetramers and anchor the enzyme at the surface of neuron and muscle (Massoulie, 2002).	Proline	135-142	acetylcholinesterase (Cartwright blood group)	Homo sapiens	192-196
17132515-1	2006	A special class of glycosylation occurs on a proline residue of the cytoplasmic/nuclear protein Skp1 in the social amoeba Dictyostelium.	Proline	45-52	S-phase kinase associated protein 1	Homo sapiens	96-100
16166268-0	2006	Proline 326 in the C terminus of murine CX3CR1 prevents G-protein and phosphatidylinositol 3-kinase-dependent stimulation of Akt and extracellular signal-regulated kinase in Chinese hamster ovary cells.	Proline	0-7	chemokine (C-X3-C motif) receptor 1	Mus musculus	40-46
16166268-0	2006	Proline 326 in the C terminus of murine CX3CR1 prevents G-protein and phosphatidylinositol 3-kinase-dependent stimulation of Akt and extracellular signal-regulated kinase in Chinese hamster ovary cells.	Proline	0-7	thymoma viral proto-oncogene 1	Mus musculus	125-128
16841364-0	2006	Effective solvation of alkaline earth ions by proline-rich proteolytic peptides of galectin-3 upon electrospray ionisation.	Proline	46-53	galectin 3	Homo sapiens	83-93
16195223-4	2006	By immobilized metal affinity chromatography and a combined microcapillary LC/MALDI-TOF/ESI-ion trap mass spectrometry approach, we identified 35 sites of mitotic phosphorylation within JIP1, among which eight were present within (Ser/Thr)-Pro sequence.	Proline	240-243	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	186-190
17068076-0	2006	The molecular basis of the interaction between the proline-rich SH3-binding motif of PNRC and estrogen receptor alpha.	Proline	51-58	estrogen receptor 1	Homo sapiens	85-117
16079997-0	2006	A rust-inducible gene from flax (fis1) is involved in proline catabolism.	Proline	54-61	SET domain-containing protein	Arabidopsis thaliana	33-37
16079997-3	2006	The fis1 gene has 73% homology with an Arabidopsis gene which encodes delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDH) which is a part of the proline degradation pathway.	Proline	147-154	SET domain-containing protein	Arabidopsis thaliana	4-8
16079997-3	2006	The fis1 gene has 73% homology with an Arabidopsis gene which encodes delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDH) which is a part of the proline degradation pathway.	Proline	147-154	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	70-115
16079997-3	2006	The fis1 gene has 73% homology with an Arabidopsis gene which encodes delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDH) which is a part of the proline degradation pathway.	Proline	147-154	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	117-122
16079997-5	2006	However, plants with reduced fis1 expression have markedly increased sensitivity to exogenous proline and show alteration in epidermal cell morphology, callose deposition and the production of hydrogen peroxide during proline-induced death.	Proline	94-101	SET domain-containing protein	Arabidopsis thaliana	29-33
16079997-5	2006	However, plants with reduced fis1 expression have markedly increased sensitivity to exogenous proline and show alteration in epidermal cell morphology, callose deposition and the production of hydrogen peroxide during proline-induced death.	Proline	218-225	SET domain-containing protein	Arabidopsis thaliana	29-33
16079997-7	2006	These data indicate that the fis1 gene plays a role in proline metabolism and most likely encodes for a P5CDH enzyme.	Proline	55-62	SET domain-containing protein	Arabidopsis thaliana	29-33
16079997-7	2006	These data indicate that the fis1 gene plays a role in proline metabolism and most likely encodes for a P5CDH enzyme.	Proline	55-62	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	104-109
16721838-6	2006	The vasoactive intestinal peptide (VIP) receptor antagonist [Lys(1), Pro(2,5), Arg(3,4), Tyr(6)]-VIP (3 microM) failed to modify the EFS-induced relaxations.	Proline	69-72	vasoactive intestinal peptide	Sus scrofa	35-38
16721838-6	2006	The vasoactive intestinal peptide (VIP) receptor antagonist [Lys(1), Pro(2,5), Arg(3,4), Tyr(6)]-VIP (3 microM) failed to modify the EFS-induced relaxations.	Proline	69-72	vasoactive intestinal peptide	Sus scrofa	97-100
16052352-5	2006	However, two transporters, the proton amino acid transporter PAT1 (SLC36A1) and the IMINO transporter (SLC6A20) appear to play key roles in the resorption of glycine and proline.	Proline	170-177	solute carrier family 36 member 1	Homo sapiens	61-65
16052352-5	2006	However, two transporters, the proton amino acid transporter PAT1 (SLC36A1) and the IMINO transporter (SLC6A20) appear to play key roles in the resorption of glycine and proline.	Proline	170-177	solute carrier family 36 member 1	Homo sapiens	67-74
16052352-5	2006	However, two transporters, the proton amino acid transporter PAT1 (SLC36A1) and the IMINO transporter (SLC6A20) appear to play key roles in the resorption of glycine and proline.	Proline	170-177	solute carrier family 6 member 20	Homo sapiens	103-110
16253996-7	2005	We previously reported that MLK3 is autoinhibited through an interaction between its N-terminal SH3 domain and a proline-containing sequence found between the leucine zipper and the CRIB motif of MLK3.	Proline	113-120	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	28-32
16407075-5	2006	Our studies also reveal that the FOXP2 forkhead domain can form a domain-swapped dimer, made possible by a strategic substitution of a highly conserved proline in conventional FOX proteins with alanine in the P subfamily.	Proline	152-159	forkhead box P2	Homo sapiens	33-38
16253996-7	2005	We previously reported that MLK3 is autoinhibited through an interaction between its N-terminal SH3 domain and a proline-containing sequence found between the leucine zipper and the CRIB motif of MLK3.	Proline	113-120	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	196-200
16297854-0	2005	A region C-terminal to the proline-rich core of p47phox regulates activation of the phagocyte NADPH oxidase by interacting with the C-terminal SH3 domain of p67phox.	Proline	27-34	neutrophil cytosolic factor 1	Homo sapiens	48-55
16227627-2	2005	SYT has a conserved N-terminal domain (SNH domain) that interacts with the human paralog of Drosophila Brahma (hBRM) and Brahma-related gene 1 (BRG1) chromatin remodeling proteins and a C-terminal transactivating sequence rich in glutamine, proline, glycine, and tyrosine (QPGY domain).	Proline	241-248	synaptotagmin 1	Homo sapiens	0-3
16366565-0	2005	A stereoelectronic effect on turn formation due to proline substitution in elastin-mimetic polypeptides.	Proline	51-58	elastin	Homo sapiens	75-82
16366565-4	2005	Calorimetric and spectroscopic investigations of these three polypeptides indicate that the incorporation of the substituted proline residues had a dramatic effect upon the self-assembly of the corresponding elastin peptide.	Proline	125-132	elastin	Homo sapiens	208-215
16366565-6	2005	These results suggest that stereoelectronic effects could either enhance or hinder the self-assembly of elastin-mimetic polypeptides, depending on the influence of the proline analogue on the energetics of the beta-turn conformation that develops within the pentapeptide structural repeats above the phase transition.	Proline	168-175	elastin	Homo sapiens	104-111
16366565-8	2005	The results of the these calculations suggested a similar outcome to the experimental data for the elastin-mimetic polypeptides, in that type II beta-turn structures were stabilized for peptide segments containing (2S,4R)-fluoroproline and destabilized for segments containing (2S,4S)-fluoroproline relative to the canonical proline residue.	Proline	228-235	elastin	Homo sapiens	99-106
16263223-2	2005	FcRY is predicted to encode a protein with three immunoglobulin (Ig) domains followed by a mucin-like domain containing a proline-rich stalk and a C-terminal leucine rich region.	Proline	122-129	Fc receptor-like B	Mus musculus	0-4
16256071-2	2005	CIN85 contains three SH3 domains that specifically bind a unique proline-arginine motif (PxxxPR) found in several CIN85 effectors.	Proline	65-72	SH3 domain containing kinase binding protein 1	Homo sapiens	0-5
16256071-2	2005	CIN85 contains three SH3 domains that specifically bind a unique proline-arginine motif (PxxxPR) found in several CIN85 effectors.	Proline	65-72	SH3 domain containing kinase binding protein 1	Homo sapiens	114-119
16297854-0	2005	A region C-terminal to the proline-rich core of p47phox regulates activation of the phagocyte NADPH oxidase by interacting with the C-terminal SH3 domain of p67phox.	Proline	27-34	neutrophil cytosolic factor 2	Homo sapiens	157-164
16297854-2	2005	p67(phox) interacts with p47(phox) via simultaneous binding of the p67(phox) C-terminal SH3 domain to both the proline-rich region (PRR) of amino acid residues 360-369 and its C-terminally flanking region of p47(phox); the role of the interaction in oxidase regulation has not been fully understood.	Proline	111-118	CD33 molecule	Homo sapiens	0-3
16297854-2	2005	p67(phox) interacts with p47(phox) via simultaneous binding of the p67(phox) C-terminal SH3 domain to both the proline-rich region (PRR) of amino acid residues 360-369 and its C-terminally flanking region of p47(phox); the role of the interaction in oxidase regulation has not been fully understood.	Proline	111-118	pleckstrin	Homo sapiens	4-8
16297854-2	2005	p67(phox) interacts with p47(phox) via simultaneous binding of the p67(phox) C-terminal SH3 domain to both the proline-rich region (PRR) of amino acid residues 360-369 and its C-terminally flanking region of p47(phox); the role of the interaction in oxidase regulation has not been fully understood.	Proline	111-118	pleckstrin	Homo sapiens	25-28
16402026-4	2005	Our findings are consistent with the idea that substitutions at position proline 347 of rhodopsin interfere with the inactivation of R*.	Proline	73-80	rhodopsin	Sus scrofa	88-97
16297854-2	2005	p67(phox) interacts with p47(phox) via simultaneous binding of the p67(phox) C-terminal SH3 domain to both the proline-rich region (PRR) of amino acid residues 360-369 and its C-terminally flanking region of p47(phox); the role of the interaction in oxidase regulation has not been fully understood.	Proline	111-118	pleckstrin	Homo sapiens	29-33
16297854-2	2005	p67(phox) interacts with p47(phox) via simultaneous binding of the p67(phox) C-terminal SH3 domain to both the proline-rich region (PRR) of amino acid residues 360-369 and its C-terminally flanking region of p47(phox); the role of the interaction in oxidase regulation has not been fully understood.	Proline	111-118	CD33 molecule	Homo sapiens	0-9
16297854-2	2005	p67(phox) interacts with p47(phox) via simultaneous binding of the p67(phox) C-terminal SH3 domain to both the proline-rich region (PRR) of amino acid residues 360-369 and its C-terminally flanking region of p47(phox); the role of the interaction in oxidase regulation has not been fully understood.	Proline	111-118	pleckstrin	Homo sapiens	208-211
16297854-2	2005	p67(phox) interacts with p47(phox) via simultaneous binding of the p67(phox) C-terminal SH3 domain to both the proline-rich region (PRR) of amino acid residues 360-369 and its C-terminally flanking region of p47(phox); the role of the interaction in oxidase regulation has not been fully understood.	Proline	111-118	pleckstrin	Homo sapiens	29-33
16223483-1	2005	The adaptor protein CIN85 is widely distributed in different tissues and has three Src homology 3 (SH3) domains, a proline-rich region (PRR), and a coiled-coil domain.	Proline	115-122	SH3 domain containing kinase binding protein 1	Homo sapiens	20-25
16257397-11	2005	In the collagen-tailed molecules, four t peptides form a coiled coil around a proline-rich motif (PRAD) located in the N-terminal region of ColQ.	Proline	78-85	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	140-144
16186124-6	2005	Of the 15 PAHX residues observed to be mutated in RD patients, 11 cluster in two distinct groups around the Fe(II) (Pro(173), His(175), Gln(176), Asp(177), and His(220)) and 2OG binding sites (Trp(193), Glu(197), Ile(199), Gly(204), Asn(269), and Arg(275)).	Proline	116-119	phytanoyl-CoA 2-hydroxylase	Homo sapiens	10-14
16253215-5	2005	In these cells, rHu BChE was expressed as mostly tetrameric form by the simultaneous expression of proline-rich attachment domain.	Proline	99-106	butyrylcholinesterase	Homo sapiens	20-24
16204241-3	2005	FasL contains an 80-amino acid-long cytoplasmic tail, which includes a proline-rich domain as a bona fide Src homology 3 domain-binding site.	Proline	71-78	Fas ligand	Homo sapiens	0-4
16289152-0	2005	Regulation of the catalytic activity of PTP1B: roles for cell adhesion, tyrosine residue 66, and proline residues 309 and 310.	Proline	97-104	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	40-45
16289152-8	2005	Since the binding of p130cas and Src to PTP1B is dependent upon these proline residues, we assayed the regulation of PTP1B in mouse embryo fibroblasts deficient in these proteins.	Proline	70-77	breast cancer anti-estrogen resistance 1	Mus musculus	21-28
16289152-8	2005	Since the binding of p130cas and Src to PTP1B is dependent upon these proline residues, we assayed the regulation of PTP1B in mouse embryo fibroblasts deficient in these proteins.	Proline	70-77	Rous sarcoma oncogene	Mus musculus	33-36
16289152-8	2005	Since the binding of p130cas and Src to PTP1B is dependent upon these proline residues, we assayed the regulation of PTP1B in mouse embryo fibroblasts deficient in these proteins.	Proline	70-77	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	40-45
16154612-6	2005	], p33 can be phosphorylated in vitro at serine and threonine residues adjacent to its arginine-proline-rich RNA binding site.	Proline	96-103	inhibitor of growth family member 1	Homo sapiens	3-6
16204241-4	2005	This proline-rich domain has been implicated in FasL sorting to secretory lysosomes, and it may also be important for reverse signaling via FasL, which has been described to influence T-cell activation.	Proline	5-12	Fas ligand	Homo sapiens	48-52
16204241-4	2005	This proline-rich domain has been implicated in FasL sorting to secretory lysosomes, and it may also be important for reverse signaling via FasL, which has been described to influence T-cell activation.	Proline	5-12	Fas ligand	Homo sapiens	140-144
16204241-5	2005	Here we report the identification of the Src homology 3 domain-containing adaptor protein PSTPIP as a FasL-interacting partner, which binds to the proline-rich domain.	Proline	147-154	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	90-96
16204241-5	2005	Here we report the identification of the Src homology 3 domain-containing adaptor protein PSTPIP as a FasL-interacting partner, which binds to the proline-rich domain.	Proline	147-154	Fas ligand	Homo sapiens	102-106
16099885-1	2005	High-throughput genomic technology identified an association between a single nucleotide polymorphism (SNP), a proline (P387) rather than the predominant alanine (A387) at position 387 in thrombospondin-4 (TSP-4) and premature myocardial infarction.	Proline	111-118	thrombospondin 4	Homo sapiens	188-204
16095818-4	2005	The majority of tau phosphorylation sites are Ser/Thr-Pro motifs, which are known to exist in two distinct cis and trans conformations.	Proline	54-57	microtubule associated protein tau	Homo sapiens	16-19
16332860-4	2005	An L-proline-accumulating laboratory strain carries a mutant allele of PRO1, pro1(D154N), which encodes the Asp154Asn mutant gamma-glutamyl kinase.	Proline	3-12	glutamate 5-kinase	Saccharomyces cerevisiae S288C	71-75
16332860-4	2005	An L-proline-accumulating laboratory strain carries a mutant allele of PRO1, pro1(D154N), which encodes the Asp154Asn mutant gamma-glutamyl kinase.	Proline	3-12	glutamate 5-kinase	Saccharomyces cerevisiae S288C	77-81
16024575-6	2005	At these concentrations, ANG-(1-7) had inhibitory effects on collagen synthesis as assessed by [3H]proline incorporation and decreased mRNA expression of growth factors in ARCFs.	Proline	99-106	angiogenin	Rattus norvegicus	25-33
16099885-1	2005	High-throughput genomic technology identified an association between a single nucleotide polymorphism (SNP), a proline (P387) rather than the predominant alanine (A387) at position 387 in thrombospondin-4 (TSP-4) and premature myocardial infarction.	Proline	111-118	thrombospondin 4	Homo sapiens	206-211
16362795-2	2005	TP53 codon 72, which produces variant proteins with an arginine (Arg) or proline (Pro), has been reported to be associated with cancers of the lung, oesophagus, stomach and cervix.	Proline	73-80	tumor protein p53	Homo sapiens	0-4
16362795-2	2005	TP53 codon 72, which produces variant proteins with an arginine (Arg) or proline (Pro), has been reported to be associated with cancers of the lung, oesophagus, stomach and cervix.	Proline	82-85	tumor protein p53	Homo sapiens	0-4
16245011-4	2005	The ADGF proteins share a novel amino acid motif, "MPKG," within which the proline and lysine residues are also conserved in the ADAL and ADA subfamilies.	Proline	75-82	adenosine deaminase like	Homo sapiens	129-133
16339720-7	2005	Viability is also maintained when two proline residues are inserted in the juxtamembrane of Sso1p, suggesting that helical continuity between the transmembrane domain and the core coiled-coil domain is not absolutely required.	Proline	38-45	syntaxin	Saccharomyces cerevisiae S288C	92-97
16052172-2	2005	Lyp is expressed in lymphocytes, where it physically associates through its proline-rich motif (called P1) with the SH3 domain of the protein tyrosine kinase Csk, an important suppressor of the Src family of kinases Lck and Fyn, which mediate TCR signaling.	Proline	76-83	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	0-3
16052172-4	2005	It was reported that a missense single nucleotide polymorphism , R620W (rs2476601), 1858C-&gt;T encodes an amino-acid change in the P1 proline-rich motif of the gene PTPN22 and is associated with SLE in North American white individuals.	Proline	135-142	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	166-172
16322390-6	2005	One patient with sporadic IHH and consanguineous parents showed a novel homozygous sequence variation of the GPR54 gene (1001_1002insC) resulting in an open reading frame shift and elongation of 43 amino acids with an increased number of proline residues in the intracellular receptor domain.	Proline	238-245	KISS1 receptor	Homo sapiens	109-114
16245011-4	2005	The ADGF proteins share a novel amino acid motif, "MPKG," within which the proline and lysine residues are also conserved in the ADAL and ADA subfamilies.	Proline	75-82	adenosine deaminase	Homo sapiens	129-132
16179990-2	2005	In this study, the gene Delta1 -pyrroline-5-carboxylate dehydrogenase (P5CDH), which catalyzes the second step in the conversion of proline to glutamate, is characterized in a number of cereal species.	Proline	132-139	P5CDH	Hordeum vulgare	71-76
16317164-6	2005	Two highly polymorphic markers, alanine codon repeats and a proline-leucine polymorphism (198P/L) present in the GPX1 gene, were used to examine LOH at this locus.	Proline	60-67	glutathione peroxidase 1	Homo sapiens	113-117
16155211-2	2005	An HIF-1alpha-specific prolyl-hydroxylase (PHD) catalyzes hydroxylation of the proline-564 and/or -402 residues of HIF-1alpha by an oxygen molecule.	Proline	79-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	3-13
16155211-2	2005	An HIF-1alpha-specific prolyl-hydroxylase (PHD) catalyzes hydroxylation of the proline-564 and/or -402 residues of HIF-1alpha by an oxygen molecule.	Proline	79-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
16307686-2	2005	Furthermore, the polymorphism at codon 72 (encoding either arginine or proline) of the p53 tumor-suppressor gene is discussed as a possible determinant for cancer risk.	Proline	71-78	tumor protein p53	Homo sapiens	87-90
16203727-10	2005	Similarly, mutation of the proline repeat in the PY motif of gamma-mENaC disrupted only Nedd4-2 regulation having no effect on regulation by K44A and epsin.	Proline	27-34	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	67-72
16203727-10	2005	Similarly, mutation of the proline repeat in the PY motif of gamma-mENaC disrupted only Nedd4-2 regulation having no effect on regulation by K44A and epsin.	Proline	27-34	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	88-95
16409756-5	2005	RESULTS: Mutation analysis of the myocilin gene showed a C-to-T transition at the 1, 109 th nucleotide in exon 3 resulting in a change of amino acid from proline to leucine (Pro370Leu).	Proline	154-161	myocilin	Homo sapiens	34-42
16233902-8	2005	Comparison of the native structure of P5CR to structures complexed with L-proline and NADP+ in two quite different primary sequence backgrounds provides unique information about key functional features: the active site and the catalytic mechanism.	Proline	72-81	pyrroline-5-carboxylate reductase 1	Homo sapiens	38-42
16198310-0	2005	A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation.	Proline	2-9	small ubiquitin like modifier 4	Homo sapiens	31-37
16198310-3	2005	Here, we report that SUMO-4 differs from SUMO-1, -2, and -3 in that the maturation process of SUMO-4 to active form containing C-terminal di-glycine residues is inhibited by a unique proline residue located at position 90 (Pro-90).	Proline	183-190	small ubiquitin like modifier 4	Homo sapiens	21-27
16198310-3	2005	Here, we report that SUMO-4 differs from SUMO-1, -2, and -3 in that the maturation process of SUMO-4 to active form containing C-terminal di-glycine residues is inhibited by a unique proline residue located at position 90 (Pro-90).	Proline	183-190	small ubiquitin like modifier 1	Homo sapiens	41-59
16198310-3	2005	Here, we report that SUMO-4 differs from SUMO-1, -2, and -3 in that the maturation process of SUMO-4 to active form containing C-terminal di-glycine residues is inhibited by a unique proline residue located at position 90 (Pro-90).	Proline	183-190	small ubiquitin like modifier 4	Homo sapiens	94-100
16198310-3	2005	Here, we report that SUMO-4 differs from SUMO-1, -2, and -3 in that the maturation process of SUMO-4 to active form containing C-terminal di-glycine residues is inhibited by a unique proline residue located at position 90 (Pro-90).	Proline	223-226	small ubiquitin like modifier 4	Homo sapiens	21-27
16198310-3	2005	Here, we report that SUMO-4 differs from SUMO-1, -2, and -3 in that the maturation process of SUMO-4 to active form containing C-terminal di-glycine residues is inhibited by a unique proline residue located at position 90 (Pro-90).	Proline	223-226	small ubiquitin like modifier 4	Homo sapiens	94-100
16267577-1	2005	The stereochemistry of thiodipeptides of proline [e.g. Ala-Psi[CS-N]-Pro] can be controlled using pH, allowing the trans-preference for substrates of the peptide transporter PepT1 to be confirmed.	Proline	41-48	solute carrier family 15 member 1	Homo sapiens	174-179
16233902-3	2005	In both pathways, the last step of biosynthesis, the conversion of delta1-pyrroline-5-carboxylate (P5C) to L-proline, is catalyzed by delta1-pyrroline-5-carboxylate reductase (P5CR) using NAD(P)H as a cofactor.	Proline	107-116	pyrroline-5-carboxylate reductase 1	Homo sapiens	67-97
16233902-3	2005	In both pathways, the last step of biosynthesis, the conversion of delta1-pyrroline-5-carboxylate (P5C) to L-proline, is catalyzed by delta1-pyrroline-5-carboxylate reductase (P5CR) using NAD(P)H as a cofactor.	Proline	107-116	pyrroline-5-carboxylate reductase 1	Homo sapiens	99-102
16233902-3	2005	In both pathways, the last step of biosynthesis, the conversion of delta1-pyrroline-5-carboxylate (P5C) to L-proline, is catalyzed by delta1-pyrroline-5-carboxylate reductase (P5CR) using NAD(P)H as a cofactor.	Proline	107-116	pyrroline-5-carboxylate reductase 1	Homo sapiens	134-174
16233902-3	2005	In both pathways, the last step of biosynthesis, the conversion of delta1-pyrroline-5-carboxylate (P5C) to L-proline, is catalyzed by delta1-pyrroline-5-carboxylate reductase (P5CR) using NAD(P)H as a cofactor.	Proline	107-116	pyrroline-5-carboxylate reductase 1	Homo sapiens	176-180
16274242-13	2005	The proline isomerization phase is modulated by both pK(HL) and pK(H2) indicating that it is sensitive to protein conformation.	Proline	4-11	relaxin 2	Homo sapiens	64-69
16275904-1	2005	In cells of Saccharomyces cerevisiae, using ammonia as a source of nitrogen, Gln3p is sequestered in the cytoplasm by Ure2p but enters the nucleus when the cells are shifted to a nonpreferred source of nitrogen such as proline.	Proline	219-226	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	77-82
16161116-6	2005	The cleavage sites of the enzyme and, for the first time, the extent and location of proline hydroxylation in human skin elastin were determined.	Proline	85-92	elastin	Homo sapiens	121-128
16356114-7	2005	In contrast, the hemin oxidation system appeared reactive toward LDL apoB-100 proline and arginine residues.	Proline	78-85	apolipoprotein B	Homo sapiens	69-77
16182243-2	2005	This process requires hydroxylation of specific prolines in HIF-1alpha by HIF prolyl hydroxylase domain (PHD)-containing enzymes, leading to its specific interactions with von Hippel-Lindau protein-Elongin B-Elongin C (VBC).	Proline	48-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
16182243-2	2005	This process requires hydroxylation of specific prolines in HIF-1alpha by HIF prolyl hydroxylase domain (PHD)-containing enzymes, leading to its specific interactions with von Hippel-Lindau protein-Elongin B-Elongin C (VBC).	Proline	48-56	elongin B	Homo sapiens	198-207
16182243-2	2005	This process requires hydroxylation of specific prolines in HIF-1alpha by HIF prolyl hydroxylase domain (PHD)-containing enzymes, leading to its specific interactions with von Hippel-Lindau protein-Elongin B-Elongin C (VBC).	Proline	48-56	elongin C	Homo sapiens	208-217
16157601-4	2005	The central region includes 11 mutations, and an isoleucine-proline motif (positions 2427 and 2428) in the same region is predicted to contribute to the binding of FKBP12.6 protein.	Proline	60-67	FKBP prolyl isomerase 1B	Homo sapiens	164-172
16171775-6	2005	The SH3 domain is known to interact with the proline-rich domain of mDab2, while even no function has been reported about the FCH domain.	Proline	45-52	disabled 2, mitogen-responsive phosphoprotein	Mus musculus	68-73
16356114-2	2005	gamma-Glutamyl semialdehyde (gammaGSA) is a product of hemin (Fe(3+)-protoporphyrin IX)-catalyzed oxidation of apolipoprotein B-100 (apoB- 100) proline and arginine residues.	Proline	144-151	apolipoprotein B	Homo sapiens	111-131
16356114-2	2005	gamma-Glutamyl semialdehyde (gammaGSA) is a product of hemin (Fe(3+)-protoporphyrin IX)-catalyzed oxidation of apolipoprotein B-100 (apoB- 100) proline and arginine residues.	Proline	144-151	apolipoprotein B	Homo sapiens	133-142
16356114-11	2005	In conclusion, glucose promotes iron-mediated oxidation of apoB- 100 proline and arginine residues via a superoxide-dependent mechanism, thus rendering the LDL particles more atherogenic.	Proline	69-76	apolipoprotein B	Homo sapiens	59-68
16356114-5	2005	In vitro studies revealed that apoB-100 proline and arginine residues are not oxidized to HAVA by HOCl or the myeloperoxidase/hydrogen peroxide (H(2)O(2)) oxidation system.	Proline	40-47	apolipoprotein B	Homo sapiens	31-39
21783632-7	2005	Prolidase [E.C.3.4.13.9] is a cytosolic metalloproteinase, which specifically splits imidodipeptides with C-terminal proline that is recycled for collagen biosynthesis.	Proline	117-124	peptidase D	Homo sapiens	0-9
16004603-6	2005	Using various deletion mutants of TSG101, the central PRR (proline-rich region) was found to be sufficient for interaction with ALG-2 by the GST-pull-down assay.	Proline	59-66	tumor susceptibility 101	Homo sapiens	34-40
16004603-6	2005	Using various deletion mutants of TSG101, the central PRR (proline-rich region) was found to be sufficient for interaction with ALG-2 by the GST-pull-down assay.	Proline	59-66	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	128-133
16227835-5	2005	RESULTS: A novel heterozygous missense mutation (1508G--&gt;C), predicting the substitution of a proline for an arginine (R503P) was detected in the helix termination motif of the keratin 3 polypeptide in family 1.	Proline	97-104	keratin 3	Homo sapiens	180-189
16297201-2	2005	hKPRP gene is located in the region of epidermal differentiation complex on chromosome 1q21, and its approximately 2.5 kb mRNA encodes 579 amino acid protein with high proline content (18%).	Proline	168-175	keratinocyte proline rich protein	Homo sapiens	0-5
16177004-10	2005	Gal-9 reversed the high-glucose-mediated upregulation of p27(Kip1) and p21(Cip1) and inhibited cell-cycle-dependent hypertrophy, i.e., reduced [(3)H]proline incorporation.	Proline	149-156	lectin, galactose binding, soluble 9	Mus musculus	0-5
16384793-5	2005	The vph1-disrupted cells lacking vacuolar-ATPase activity showed resistance to heat shock without any change in proline localization, but showed severe growth defects in an ethanol-containing medium.	Proline	112-119	H(+)-transporting V0 sector ATPase subunit a	Saccharomyces cerevisiae S288C	4-8
16234811-3	2005	Two of the candidate risk genes encode the enzymes proline dehydrogenase (PRODH) and catechol-O-methyltransferase (COMT), which modulate the levels of a putative neuromodulator (L-proline) and the neurotransmitter dopamine, respectively.	Proline	178-187	proline dehydrogenase	Mus musculus	51-72
16228008-2	2005	Their function is modulated through interactions with regulatory proteins including CIN85 and PIX, which recognize a proline-arginine motif in Cbl and thus promote or inhibit receptor endocytosis.	Proline	117-124	SH3 domain containing kinase binding protein 1	Homo sapiens	84-89
16228008-2	2005	Their function is modulated through interactions with regulatory proteins including CIN85 and PIX, which recognize a proline-arginine motif in Cbl and thus promote or inhibit receptor endocytosis.	Proline	117-124	Cbl proto-oncogene	Homo sapiens	143-146
16234811-3	2005	Two of the candidate risk genes encode the enzymes proline dehydrogenase (PRODH) and catechol-O-methyltransferase (COMT), which modulate the levels of a putative neuromodulator (L-proline) and the neurotransmitter dopamine, respectively.	Proline	178-187	proline dehydrogenase	Mus musculus	74-79
16228008-3	2005	We report the structures of SH3 domains of CIN85 and beta-PIX in complex with a proline-arginine peptide from Cbl-b.	Proline	80-87	SH3 domain containing kinase binding protein 1	Homo sapiens	43-48
16373326-6	2005	When expressed heterologously in a mammalian cell line, rabbit PAT1 mediates pH-dependent, Na(+)-independent uptake of proline, glycine, l-alanine and alpha-(methylamino)isobutyric acid.	Proline	119-126	proton-coupled amino acid transporter 1	Oryctolagus cuniculus	63-67
16373326-9	2005	In the presence of Na+ and under conditions in which PAT1 transport function was suppressed, a second proline uptake system was detected that exhibited functional characteristics similar to those of the IMINO system.	Proline	102-109	proton-coupled amino acid transporter 1	Oryctolagus cuniculus	53-57
16228008-3	2005	We report the structures of SH3 domains of CIN85 and beta-PIX in complex with a proline-arginine peptide from Cbl-b.	Proline	80-87	Rho guanine nucleotide exchange factor 7	Homo sapiens	53-61
16234811-3	2005	Two of the candidate risk genes encode the enzymes proline dehydrogenase (PRODH) and catechol-O-methyltransferase (COMT), which modulate the levels of a putative neuromodulator (L-proline) and the neurotransmitter dopamine, respectively.	Proline	178-187	catechol-O-methyltransferase	Mus musculus	85-113
16228008-3	2005	We report the structures of SH3 domains of CIN85 and beta-PIX in complex with a proline-arginine peptide from Cbl-b.	Proline	80-87	Cbl proto-oncogene B	Homo sapiens	110-115
16373326-10	2005	The functional characteristics of rabbit PAT1 in either mammalian cells or renal BBMV suggest that PAT1 is the low-affinity transporter of proline, glycine and hydroxyproline believed to be defective in patients with iminoglycinuria.	Proline	139-146	solute carrier family 36 (proton/amino acid symporter), member 1	Mus musculus	41-45
16373326-10	2005	The functional characteristics of rabbit PAT1 in either mammalian cells or renal BBMV suggest that PAT1 is the low-affinity transporter of proline, glycine and hydroxyproline believed to be defective in patients with iminoglycinuria.	Proline	139-146	solute carrier family 36 member 1	Homo sapiens	99-103
16234811-3	2005	Two of the candidate risk genes encode the enzymes proline dehydrogenase (PRODH) and catechol-O-methyltransferase (COMT), which modulate the levels of a putative neuromodulator (L-proline) and the neurotransmitter dopamine, respectively.	Proline	178-187	catechol-O-methyltransferase	Mus musculus	115-119
16299589-2	2005	In physiological conditions, AChE exists as tetramers associated with the proline-rich attachment domain (PRAD) of either collagen-like Q subunit (ColQ) or proline-rich membrane-anchoring protein.	Proline	74-81	acetylcholinesterase	Mus musculus	29-33
16299589-2	2005	In physiological conditions, AChE exists as tetramers associated with the proline-rich attachment domain (PRAD) of either collagen-like Q subunit (ColQ) or proline-rich membrane-anchoring protein.	Proline	74-81	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	Mus musculus	147-151
16299589-2	2005	In physiological conditions, AChE exists as tetramers associated with the proline-rich attachment domain (PRAD) of either collagen-like Q subunit (ColQ) or proline-rich membrane-anchoring protein.	Proline	156-163	acetylcholinesterase	Mus musculus	29-33
16155115-9	2005	The crystal structure of A42P rAMY2 was solved and found to differ marginally from the AMY2 structure, suggesting that the high A42P yield stems from stabilization of the mature and/or intermediate form owing to the introduced proline residue.	Proline	227-234	pancreatic alpha-amylase-like	Rattus norvegicus	30-35
16243804-9	2005	CONCLUSION: Our study indicates that breast cancer patients with the Pro/Pro variant may be less sensitive to anthracycline-based treatment than those with the Pro/Arg or Arg/Arg variant and suggests that analysis of p53 codon 72 polymorphism may provide a simple predictive marker for selecting the right breast cancer patients to anthracycline-based neoadjuvant chemotherapy in clinical setting.	Proline	69-72	tumor protein p53	Homo sapiens	217-220
16155115-9	2005	The crystal structure of A42P rAMY2 was solved and found to differ marginally from the AMY2 structure, suggesting that the high A42P yield stems from stabilization of the mature and/or intermediate form owing to the introduced proline residue.	Proline	227-234	drug-responsive transcription factor PDR3	Saccharomyces cerevisiae S288C	31-35
16123044-6	2005	In this regard, it has been recently observed that the prolyl isomerase Pin1 can interact with proteins phosphorylated on serine or threonine residues that precede prolines (pS/T-P), such as the transcription factors p53 and c-Jun, thereby controlling their activity by promoting the cis-trans isomerization of these pS/T-P bonds.	Proline	164-172	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	72-76
16123044-6	2005	In this regard, it has been recently observed that the prolyl isomerase Pin1 can interact with proteins phosphorylated on serine or threonine residues that precede prolines (pS/T-P), such as the transcription factors p53 and c-Jun, thereby controlling their activity by promoting the cis-trans isomerization of these pS/T-P bonds.	Proline	164-172	tumor protein p53	Homo sapiens	217-220
16123044-6	2005	In this regard, it has been recently observed that the prolyl isomerase Pin1 can interact with proteins phosphorylated on serine or threonine residues that precede prolines (pS/T-P), such as the transcription factors p53 and c-Jun, thereby controlling their activity by promoting the cis-trans isomerization of these pS/T-P bonds.	Proline	164-172	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	225-230
16220978-1	2005	Two 1,3,5-trisubstituted aromatic scaffolds intended to serve as gamma-turn mimetics have been synthesized and incorporated in five pseudopeptide analogues of angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe), replacing Val-Tyr-Ile, Val-Tyr, or Tyr-Ile.	Proline	199-202	angiotensinogen	Homo sapiens	159-173
20641210-19	2004	From the results of investigating a small library of RGD peptides for their binding activity to the alphavbeta3 integrin, a linear hexapeptide, Gly-Arg-Asp-Ser-Pro-Lys (GRDSPK), lacking the RGD sequence was conjugated with Cypate as Cyp-GRD to study in vivo biodistribution of the tracer in tumor-bearing mice (18).	Proline	160-163	peptidyl-prolyl isomerase G (cyclophilin G)	Mus musculus	223-226
16126177-1	2005	Although vinexin was originally identified as a protein binding to the proline-rich hinge region of vinculin, the functions and biochemical properties of the vinexin-vinculin interaction are not known.	Proline	71-78	sorbin and SH3 domain containing 3	Homo sapiens	9-16
16126177-1	2005	Although vinexin was originally identified as a protein binding to the proline-rich hinge region of vinculin, the functions and biochemical properties of the vinexin-vinculin interaction are not known.	Proline	71-78	vinculin	Homo sapiens	100-108
16182291-4	2005	The proline/serine-rich domain (P/S domain) of Mel-18 is required to interact with cyclin D2, and the N-terminal region of cyclin D2 is necessary to interact with Mel-18.	Proline	4-11	polycomb group ring finger 2	Homo sapiens	47-53
16182291-4	2005	The proline/serine-rich domain (P/S domain) of Mel-18 is required to interact with cyclin D2, and the N-terminal region of cyclin D2 is necessary to interact with Mel-18.	Proline	4-11	cyclin D2	Homo sapiens	83-92
16221862-1	2005	SH3 protein interacting with Nck, 90 kDa (SPIN90) is an Nck-binding protein that contains one Src homology 3 (SH3) domain, three proline-rich domains (PRDs), a serine/threonine-rich region, and a hydrophobic C-terminal region.	Proline	129-136	NCK interacting protein with SH3 domain	Homo sapiens	0-40
16221862-1	2005	SH3 protein interacting with Nck, 90 kDa (SPIN90) is an Nck-binding protein that contains one Src homology 3 (SH3) domain, three proline-rich domains (PRDs), a serine/threonine-rich region, and a hydrophobic C-terminal region.	Proline	129-136	NCK interacting protein with SH3 domain	Homo sapiens	42-48
16234850-6	2005	A database search for proteins potentially regulated by oxygen tension revealed that ALAS2 contained a sequence of amino acids (LXXLAP where L is leucine, X is any amino acid, A is alanine, and P is proline) not occurring in ALAS1, which may be hydroxylated under normoxic conditions (21% O2) and target the enzyme for ubiquitination and degradation by the proteasome.	Proline	199-206	5'-aminolevulinate synthase 2	Homo sapiens	85-90
16174443-0	2005	Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis.	Proline	14-21	AKT serine/threonine kinase 1	Homo sapiens	27-30
16174443-0	2005	Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis.	Proline	14-21	AKT1 substrate 1	Homo sapiens	41-47
16174443-1	2005	AIM: To study the expression of proline-rich Akt-substrate PRAS40 in the cell survival pathway and tumor progression.	Proline	32-39	AKT serine/threonine kinase 1	Homo sapiens	45-48
16174443-1	2005	AIM: To study the expression of proline-rich Akt-substrate PRAS40 in the cell survival pathway and tumor progression.	Proline	32-39	AKT1 substrate 1	Homo sapiens	59-65
16234850-9	2005	Mutation of a key proline within the LXXLAP sequence of ALAS2 also stabilized the protein beyond 36 h under normoxic conditions.	Proline	18-25	5'-aminolevulinate synthase 2	Homo sapiens	56-61
15905205-7	2005	Importantly, patient survival did significantly differ: those patients having a TP53 mutation on the proline allele had the worst survival outcomes (hazards ratio = 2.6, P &lt; 0.03).	Proline	101-108	tumor protein p53	Homo sapiens	80-84
15905205-9	2005	Our data suggest that there are selective pressures for loss of the TP53 proline allele in non-small cell lung cancer.	Proline	73-80	tumor protein p53	Homo sapiens	68-72
16203772-1	2005	PURPOSE: The Arg/Pro polymorphism in codon 72 of p53 was recently associated with age of onset of colorectal cancer in Lynch syndrome.	Proline	17-20	tumor protein p53	Homo sapiens	49-52
16054204-4	2005	RESULTS: The observed association of proline homozygosity at codon 72 of p53 with CaCx infection (Bhattacharya, P., Duttagupta, C., Sengupta, S. 2002.Proline homozygosity in codon 72 of p53: A risk genotype for Human Papillomavirus related cervical cancer in Indian women.	Proline	37-44	tumor protein p53	Homo sapiens	73-76
16219545-10	2005	Mutations in the p85alpha-SH3 region responsible for proline-rich motif binding either abrogate or enhance these interactions.	Proline	53-60	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	17-25
15901675-3	2005	Up to six proline/hydroxyproline conversions and variable amounts of arabinosylation (Pro/Hyp + Ara) were found in the hinge region of maize-expressed hIgA1 heavy chain (HC) by using a combination of matrix-assisted laser-desorption ionization mass spectrometry (MALDI MS), chromatography, and amino acid analysis.	Proline	10-17	immunoglobulin heavy constant alpha 1	Homo sapiens	151-156
16054204-4	2005	RESULTS: The observed association of proline homozygosity at codon 72 of p53 with CaCx infection (Bhattacharya, P., Duttagupta, C., Sengupta, S. 2002.Proline homozygosity in codon 72 of p53: A risk genotype for Human Papillomavirus related cervical cancer in Indian women.	Proline	37-44	tumor protein p53	Homo sapiens	186-189
16054204-4	2005	RESULTS: The observed association of proline homozygosity at codon 72 of p53 with CaCx infection (Bhattacharya, P., Duttagupta, C., Sengupta, S. 2002.Proline homozygosity in codon 72 of p53: A risk genotype for Human Papillomavirus related cervical cancer in Indian women.	Proline	150-157	tumor protein p53	Homo sapiens	73-76
16054204-4	2005	RESULTS: The observed association of proline homozygosity at codon 72 of p53 with CaCx infection (Bhattacharya, P., Duttagupta, C., Sengupta, S. 2002.Proline homozygosity in codon 72 of p53: A risk genotype for Human Papillomavirus related cervical cancer in Indian women.	Proline	150-157	tumor protein p53	Homo sapiens	186-189
16054204-8	2005	The p21 arginine allele was significantly associated with CaCx in the p53 proline non-homozygous group of subjects (OR(age-adjusted) = 2.68; 95% CI: 1.21-5.91; P = 0.01), and specifically in the p53 heterozygous group (OR(age-adjusted) = 2.91; 95% CI = 1.12-7.56; P = 0.03).	Proline	74-81	H3 histone pseudogene 16	Homo sapiens	4-7
16054204-8	2005	The p21 arginine allele was significantly associated with CaCx in the p53 proline non-homozygous group of subjects (OR(age-adjusted) = 2.68; 95% CI: 1.21-5.91; P = 0.01), and specifically in the p53 heterozygous group (OR(age-adjusted) = 2.91; 95% CI = 1.12-7.56; P = 0.03).	Proline	74-81	tumor protein p53	Homo sapiens	70-73
16054204-10	2005	However, the two risk factors, p53 proline homozygosity and p21 arginine allele, although part of a common causal pathway, appear to act in a mutually exclusive manner.	Proline	35-42	tumor protein p53	Homo sapiens	31-34
16157790-3	2005	Here we tested the hypothesis that upregulation of c-Src by aldosterone plays a role in increased mitogen-activated protein (MAP) kinase activation, [3H]-proline incorporation, and NADPH-driven generation of reactive oxygen species, thereby inducing cell growth, collagen production, and inflammation, respectively, in vascular smooth muscle cells from spontaneously hypertensive rats.	Proline	154-161	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	51-56
16033917-5	2005	Sequence comparison of collagen type XI alpha1 and alpha2 peptides across species shows that the replaced proline is an evolutionarily conserved amino acid.	Proline	106-113	collagen type XI alpha 1 chain	Homo sapiens	23-46
16708114-6	2005	Predicted Xin proteins all contain a novel 16-amino acid repeating unit (Xin repeat), a putative DNA binding domain and nuclear localization signal, as well as a proline-rich region.	Proline	162-169	xin actin binding repeat containing 1	Gallus gallus	10-13
16199549-1	2005	The polymorphic variants at codon 72 of the p53 gene were shown to be functionally distinct in vitro, whereby the arginine (arg) variant induces apoptosis more efficiently than the proline (pro) variant.	Proline	181-188	tumor protein p53	Homo sapiens	44-47
16172238-1	2005	Polymorphism at codon 72 of p53 results in either the arginine or proline form of p53, whose functional significance in carcinogenesis is controversial.	Proline	66-73	tumor protein p53	Homo sapiens	28-31
16305332-9	2005	Our results suggest that the interaction of the cytoplasmic tail of CD34 with the shallow proline-rich motif-binding groove of Crk-L is essential for the function of CD34 in stem cell development.	Proline	90-97	CD34 molecule	Homo sapiens	68-72
16305332-9	2005	Our results suggest that the interaction of the cytoplasmic tail of CD34 with the shallow proline-rich motif-binding groove of Crk-L is essential for the function of CD34 in stem cell development.	Proline	90-97	CRK proto-oncogene, adaptor protein	Homo sapiens	127-130
16305332-9	2005	Our results suggest that the interaction of the cytoplasmic tail of CD34 with the shallow proline-rich motif-binding groove of Crk-L is essential for the function of CD34 in stem cell development.	Proline	90-97	CD34 molecule	Homo sapiens	166-170
16000308-1	2005	The GYF domain of CD2BP2 serves as an adapter that recognizes proline-rich sequences in intracellular proteins.	Proline	62-69	CD2 cytoplasmic tail binding protein 2	Homo sapiens	18-24
16139300-2	2005	With 24 three-helix, spectrin repeats interspersed with proline-rich hinges, dystrophin"s large size is an impediment to gene therapy, prompting the construction of mini-dystrophins.	Proline	56-63	dystrophin, muscular dystrophy	Mus musculus	77-87
16081046-5	2005	This residue was thus mutated in the secreted isoform of NEP2, as were proline residues located in its vicinity.	Proline	71-78	membrane metallo-endopeptidase-like 1	Mus musculus	57-61
16174846-6	2005	Pol lambda is phosphorylated in vitro by several Cdk/cyclin complexes, including Cdk2/cyclin A, in its proline-serine-rich domain.	Proline	103-110	cyclin dependent kinase 2	Homo sapiens	81-85
16174846-6	2005	Pol lambda is phosphorylated in vitro by several Cdk/cyclin complexes, including Cdk2/cyclin A, in its proline-serine-rich domain.	Proline	103-110	cyclin A2	Homo sapiens	86-94
15994299-2	2005	p22phox associates with gp91phox and, through its proline-rich C terminus, provides a binding site for the tandem Src homology 3 domains of the activating subunit p47phox.	Proline	50-57	cytochrome b-245 alpha chain	Homo sapiens	0-7
15994299-2	2005	p22phox associates with gp91phox and, through its proline-rich C terminus, provides a binding site for the tandem Src homology 3 domains of the activating subunit p47phox.	Proline	50-57	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	114-117
15994299-2	2005	p22phox associates with gp91phox and, through its proline-rich C terminus, provides a binding site for the tandem Src homology 3 domains of the activating subunit p47phox.	Proline	50-57	neutrophil cytosolic factor 1	Homo sapiens	163-170
16093351-5	2005	A small, proline-rich region in the C-terminal half of MAP4 bound directly to a Sept 2:6:7 heterotrimer, and to the Sept2 monomer.	Proline	9-16	microtubule associated protein 4	Homo sapiens	55-59
16093351-5	2005	A small, proline-rich region in the C-terminal half of MAP4 bound directly to a Sept 2:6:7 heterotrimer, and to the Sept2 monomer.	Proline	9-16	septin 2	Homo sapiens	116-121
16155203-3	2005	Tip forms additional contacts outside its classical proline-rich recognition motif and, in particular, a strictly conserved leucine (L186) of the C-terminally adjacent sequence stretch packs into a hydrophobic pocket on the Lyn surface.	Proline	52-59	TOR signaling pathway regulator	Homo sapiens	0-3
16137687-5	2005	Biotinylated SH3 domains were also used for specific identification of target proline-rich sequences in synaptojanin and ACK1 on synthetic peptides arrays.	Proline	78-85	tyrosine kinase non receptor 2	Homo sapiens	121-125
16137687-7	2005	While SNX9 targets a number of sequences within the proline-rich regions of synaptojanin, a single site was identified in human ACK1.	Proline	52-59	sorting nexin 9	Homo sapiens	6-10
16039995-1	2005	Thioredoxin (TRX) is a 12-kDa redox (reduction/oxidation)-active protein that has a highly conserved site (-Cys-Gly-Pro-Cys-) and scavenges reactive oxygen species.	Proline	116-119	thioredoxin 1	Mus musculus	0-11
16039995-1	2005	Thioredoxin (TRX) is a 12-kDa redox (reduction/oxidation)-active protein that has a highly conserved site (-Cys-Gly-Pro-Cys-) and scavenges reactive oxygen species.	Proline	116-119	thioredoxin 1	Mus musculus	13-16
16106293-9	2005	1 : 1); this is probably a result of both the C-3 pro-S and C-2 hydrogen atoms being accessible to the reactive oxidising intermediate in this substrate.	Proline	50-55	complement C3	Homo sapiens	46-49
16141521-7	2005	Furthermore, systematic proline substitution analyses revealed that the beta-turn structure at positions 22 and 23 of Abeta42 plays a crucial role in the aggregation and neurotoxicity of Abeta peptides.	Proline	24-31	amyloid beta (A4) precursor protein	Mus musculus	118-123
16082224-1	2005	A common polymorphism at codon 72 in p53 gene leads to an arginine to proline aminoacidic substitution which affects in an age-dependent manner the susceptibility of cells to undergo apoptosis after oxidative stress.	Proline	70-77	tumor protein p53	Homo sapiens	37-40
16172238-1	2005	Polymorphism at codon 72 of p53 results in either the arginine or proline form of p53, whose functional significance in carcinogenesis is controversial.	Proline	66-73	tumor protein p53	Homo sapiens	82-85
16172238-2	2005	We have investigated if the expression of these p53 polymorphs is selectively regulated, using mRNA from peripheral blood of healthy Asian (Chinese) and the Caucasian (Polish) arginine/proline (arg/pro) heterozygote subjects.	Proline	185-192	tumor protein p53	Homo sapiens	48-51
16172238-2	2005	We have investigated if the expression of these p53 polymorphs is selectively regulated, using mRNA from peripheral blood of healthy Asian (Chinese) and the Caucasian (Polish) arginine/proline (arg/pro) heterozygote subjects.	Proline	185-188	tumor protein p53	Homo sapiens	48-51
16140199-5	2005	TGF-beta1 (10 and 100 ng/ml) stimulated both (3)H-proline and (35)S-sulfate uptake, showing a dose-dependent response for both and a temporal response for (35)S-sulfate uptake.	Proline	50-57	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	0-9
16140998-8	2005	CONCLUSIONS: The p53 codon 72 Arg/Pro polymorphism is not associated with age of onset or severity of glaucoma.	Proline	34-37	tumor protein p53	Homo sapiens	17-20
16055315-6	2005	This C. albicans gene is located in chromosome R. STE13ca gene increases its levels of expression in conditions of nutritional stress (proline as nitrogen source) and during formation of the germinal tube, suggesting a basic biological function for the STE13ca in this yeast.	Proline	135-142	Ste13p	Saccharomyces cerevisiae S288C	50-55
16140199-6	2005	IGF-I (5 ng/ml) and bFGF (25 and 100 ng/ml) showed increases in (3)H-proline uptake by the third week of growth factor addition.	Proline	68-76	insulin-like growth factor I	Oryctolagus cuniculus	0-5
16135792-2	2005	Introduction of point mutations in the N-terminal and C-terminal SH2 domain and SH3 domain of p85alpha, which disrupt their ability to bind phosphotyrosine and proline-rich motifs, respectively, abrogated their interaction with the BCR/ABL protein network.	Proline	160-167	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	94-102
16212427-10	2005	Prolyl endopeptidase treatment was shown to abolish the antigenicity of both the 33-mer and the 26-mer peptides, and was also predicted to have comparable effects on other proline-rich putatively immunotoxic peptides identified from other polypeptides within the gluten proteome.	Proline	172-179	prolyl endopeptidase	Homo sapiens	0-20
16135792-2	2005	Introduction of point mutations in the N-terminal and C-terminal SH2 domain and SH3 domain of p85alpha, which disrupt their ability to bind phosphotyrosine and proline-rich motifs, respectively, abrogated their interaction with the BCR/ABL protein network.	Proline	160-167	BCR activator of RhoGEF and GTPase	Mus musculus	232-239
15907950-2	2005	We have previously shown that a diketopiperazine structurally related to the TRH metabolite cyclo-his-pro reduces neuronal cell death in vitro and in vivo.	Proline	102-105	thyrotropin releasing hormone	Rattus norvegicus	77-80
15897875-4	2005	In cells, the 65-kDa full-length ESXR1 protein is proteolytically processed into an N-terminal 45-kDa fragment containing the homeodomain, which localizes exclusively within the nucleus, and a C-terminal 20-kDa fragment consisting of a proline-rich repeat region, which is located in the cytoplasm.	Proline	236-243	ESX homeobox 1	Homo sapiens	33-38
16023078-6	2005	Subsequent analysis of the mitochondrial genome revealed a homoplastic T10191C mutation in the ND3 gene (in blood and muscle), resulting in a substitution of serine to proline.	Proline	168-175	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	95-98
16285507-4	2005	Specifically, the c-Abl SH3 domain binds to a proline-rich motif at amino acids 958-982 in the c-Abl C-terminal region.	Proline	46-53	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	18-23
16285507-4	2005	Specifically, the c-Abl SH3 domain binds to a proline-rich motif at amino acids 958-982 in the c-Abl C-terminal region.	Proline	46-53	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	95-100
16077993-2	2005	We found that the SNL glycoprotein consists of carbohydrate (69.74%) and protein content (30.26%), which has &gt;50% hydrophobic amino acids containing glycine and proline.	Proline	164-171	fascin actin-bundling protein 1	Homo sapiens	18-21
15839837-3	2005	Hepsin exhibited strong preference at the P1 position for arginine over lysine, and favoured threonine, leucine or asparagine at the P2, glutamine or lysine at the P3, and proline or lysine at the P4 position.	Proline	172-179	hepsin	Homo sapiens	0-6
15994323-7	2005	Mutagenesis of the corresponding proline in the S. cerevisiae Nha1 antiporter (Pro146) confirmed that this proline of the fifth transmembrane domain is a critical residue for antiporter function.	Proline	107-114	Nha1p	Saccharomyces cerevisiae S288C	62-66
16115959-4	2005	Fibrinogen binding to alphaIIbbeta3 triggers PTP-1B recruitment to the alphaIIbbeta3-c-Src-Csk complex in a manner that is dependent on c-Src and specific tyrosine (tyrosine 152 and 153) and proline (proline 309 and 310) residues in PTP-1B.	Proline	191-198	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	45-51
16115959-4	2005	Fibrinogen binding to alphaIIbbeta3 triggers PTP-1B recruitment to the alphaIIbbeta3-c-Src-Csk complex in a manner that is dependent on c-Src and specific tyrosine (tyrosine 152 and 153) and proline (proline 309 and 310) residues in PTP-1B.	Proline	191-198	c-src tyrosine kinase	Mus musculus	91-94
16115959-4	2005	Fibrinogen binding to alphaIIbbeta3 triggers PTP-1B recruitment to the alphaIIbbeta3-c-Src-Csk complex in a manner that is dependent on c-Src and specific tyrosine (tyrosine 152 and 153) and proline (proline 309 and 310) residues in PTP-1B.	Proline	200-207	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	45-51
16115959-4	2005	Fibrinogen binding to alphaIIbbeta3 triggers PTP-1B recruitment to the alphaIIbbeta3-c-Src-Csk complex in a manner that is dependent on c-Src and specific tyrosine (tyrosine 152 and 153) and proline (proline 309 and 310) residues in PTP-1B.	Proline	200-207	c-src tyrosine kinase	Mus musculus	91-94
15994323-7	2005	Mutagenesis of the corresponding proline in the S. cerevisiae Nha1 antiporter (Pro146) confirmed that this proline of the fifth transmembrane domain is a critical residue for antiporter function.	Proline	33-40	Nha1p	Saccharomyces cerevisiae S288C	62-66
16109171-1	2005	BACKGROUND: A common sequence polymorphism at codon 72 of the p53 gene encoding either arginine or proline was recently shown to be functionally relevant for apoptosis induction in vitro.	Proline	99-106	tumor protein p53	Homo sapiens	62-65
15959921-1	2005	We have synthesized and fully characterized four new complexes comprising the fac-[Re(CO)3]+ moiety and the ligands NH3, L-proline (Pro), or N,N-dimethylglycine (dmGly).	Proline	132-135	FA complementation group C	Homo sapiens	78-81
16083426-3	2005	The data presented here show that AurA is a basophilic Ser/Thr protein kinase recognizing the consensus R/K/N-R-X-S/T-B, where B denotes any hydrophobic residue with the exception of Pro.	Proline	183-186	aurora kinase A	Homo sapiens	34-38
16098226-5	2005	Yeast two-hybrid library screens were then carried out to identify brain-expressed proteins that interact with the C-terminal peptide and with the entire PAX6 proline-serine-threonine-rich domain.	Proline	159-166	paired box 6	Homo sapiens	154-158
15975558-3	2005	Here, we show that, in vitro, Calpain I can cleave p73 at two distinct sites: the first proline-rich region and within the oligomerization domain.	Proline	88-95	tumor protein p73	Homo sapiens	51-54
16043695-5	2005	This activity requires a Src-kinase-binding proline-rich domain of Nef and a conserved tyrosine-based motif in the cytoplasmic tail of HFE.	Proline	44-51	S100 calcium binding protein B	Homo sapiens	67-70
15950741-5	2005	Further, CD3eta-chain exon 8 amino acid sequences retained the unique characters of having high proline (Pro) and positively charged amino acid content except for rats and mice.	Proline	96-103	CD247 antigen	Mus musculus	9-15
16100168-5	2005	DNA was genotyped for the presence of a single nucleotide (C to T) polymorphism that changes residue 582 of HIF-1alpha from proline to serine.	Proline	124-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	108-118
15950741-5	2005	Further, CD3eta-chain exon 8 amino acid sequences retained the unique characters of having high proline (Pro) and positively charged amino acid content except for rats and mice.	Proline	105-108	CD247 antigen	Mus musculus	9-15
16024771-4	2005	CdGAP consists of an N-terminal RhoGAP domain and a C-terminal proline-rich region.	Proline	63-70	Rho GTPase activating protein 31	Homo sapiens	0-5
15925519-2	2005	Under normoxic conditions, one of the subunits of HIF-1, HIF-1alpha, is hydroxylated on specific proline residues to target HIF-1alpha for degradation by the ubiquitin-proteasome pathway.	Proline	97-104	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	57-67
16024771-10	2005	A putative DEF (docking for ERK FXFP) domain located in the proline-rich region of CdGAP is required for efficient binding and phosphorylation by ERK1/2.	Proline	60-67	mitogen-activated protein kinase 1	Homo sapiens	28-31
16024771-10	2005	A putative DEF (docking for ERK FXFP) domain located in the proline-rich region of CdGAP is required for efficient binding and phosphorylation by ERK1/2.	Proline	60-67	Rho GTPase activating protein 31	Homo sapiens	83-88
16024771-10	2005	A putative DEF (docking for ERK FXFP) domain located in the proline-rich region of CdGAP is required for efficient binding and phosphorylation by ERK1/2.	Proline	60-67	mitogen-activated protein kinase 3	Homo sapiens	146-152
16024780-2	2005	The alpha-subunit of HIF factor 1 (HIF-1) contains two highly conserved oxygen-dependent degradation domains (402 ODD and 564 ODD), each of which includes a proline that is hydroxylated in the presence of oxygen, allowing the von Hippel-Lindau (VHL) E3 ubiquitin ligase to interact and target HIF-1alpha to the proteasome for degradation.	Proline	157-164	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-40
16024780-3	2005	Mutation of either proline is sufficient to partially stabilize HIF-1alpha under conditions of normoxia, but the specific contributions of each hydroxylation event to the regulation of HIF-1alpha are unknown.	Proline	19-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-74
16024780-8	2005	In these domain-swapping experiments, prolyl hydroxylase domain 1 (PHD1) and PHD2 preferentially hydroxylated the proline located in the site of the original 564 ODD, while PHD3 preferred the proline 564 sequence, regardless of its location.	Proline	114-121	egl-9 family hypoxia inducible factor 2	Homo sapiens	38-65
16024780-8	2005	In these domain-swapping experiments, prolyl hydroxylase domain 1 (PHD1) and PHD2 preferentially hydroxylated the proline located in the site of the original 564 ODD, while PHD3 preferred the proline 564 sequence, regardless of its location.	Proline	114-121	egl-9 family hypoxia inducible factor 2	Homo sapiens	67-71
16024780-8	2005	In these domain-swapping experiments, prolyl hydroxylase domain 1 (PHD1) and PHD2 preferentially hydroxylated the proline located in the site of the original 564 ODD, while PHD3 preferred the proline 564 sequence, regardless of its location.	Proline	114-121	egl-9 family hypoxia inducible factor 1	Homo sapiens	77-81
16024780-8	2005	In these domain-swapping experiments, prolyl hydroxylase domain 1 (PHD1) and PHD2 preferentially hydroxylated the proline located in the site of the original 564 ODD, while PHD3 preferred the proline 564 sequence, regardless of its location.	Proline	114-121	egl-9 family hypoxia inducible factor 3	Homo sapiens	173-177
16024780-8	2005	In these domain-swapping experiments, prolyl hydroxylase domain 1 (PHD1) and PHD2 preferentially hydroxylated the proline located in the site of the original 564 ODD, while PHD3 preferred the proline 564 sequence, regardless of its location.	Proline	192-199	egl-9 family hypoxia inducible factor 2	Homo sapiens	38-65
16024780-8	2005	In these domain-swapping experiments, prolyl hydroxylase domain 1 (PHD1) and PHD2 preferentially hydroxylated the proline located in the site of the original 564 ODD, while PHD3 preferred the proline 564 sequence, regardless of its location.	Proline	192-199	egl-9 family hypoxia inducible factor 2	Homo sapiens	67-71
16024780-8	2005	In these domain-swapping experiments, prolyl hydroxylase domain 1 (PHD1) and PHD2 preferentially hydroxylated the proline located in the site of the original 564 ODD, while PHD3 preferred the proline 564 sequence, regardless of its location.	Proline	192-199	egl-9 family hypoxia inducible factor 1	Homo sapiens	77-81
16024780-8	2005	In these domain-swapping experiments, prolyl hydroxylase domain 1 (PHD1) and PHD2 preferentially hydroxylated the proline located in the site of the original 564 ODD, while PHD3 preferred the proline 564 sequence, regardless of its location.	Proline	192-199	egl-9 family hypoxia inducible factor 3	Homo sapiens	173-177
16024780-10	2005	These results indicate that hydroxylation of proline 402 is highly responsive to physiologic changes in oxygen and, therefore, plays a more important role in HIF-1alpha regulation under conditions of hypoxia than under conditions of normoxia.	Proline	45-52	hypoxia inducible factor 1 subunit alpha	Homo sapiens	158-168
16024780-11	2005	Together, these findings demonstrate that each hydroxylated proline of HIF-1alpha has a distinct activity in controlling HIF-1alpha stability in response to different levels of oxygenation.	Proline	60-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
16024780-11	2005	Together, these findings demonstrate that each hydroxylated proline of HIF-1alpha has a distinct activity in controlling HIF-1alpha stability in response to different levels of oxygenation.	Proline	60-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	121-131
16034027-1	2005	Indolicidin, a l3-residue antimicrobial peptide-amide, which is unusually rich in tryptophan and proline, is isolated from the cytoplasmic granules of bovine neutrophils.	Proline	97-104	cathelicidin-4	Bos taurus	0-11
16029433-5	2005	The analysis identified three novel exon 3 MASP2 variants introducing amino acid substitutions at positions 84 (Arg--&gt;Gln), 103 (Arg--&gt;Cys) and 111 (Pro--&gt;Leu) in the CUB1 domain.	Proline	155-158	MBL associated serine protease 2	Homo sapiens	43-48
15941661-10	2005	The adjusted odds ratio for TGF-beta1 codon 25 Arg/Pro and Pro/Pro was 2.8 (95% CI 1.4-5.7, p = 0.004).	Proline	51-54	transforming growth factor beta 1	Homo sapiens	28-37
16002738-10	2005	One of these, a nonsense genotype in a mild patient, supports expression of WASP lacking half of the proline-rich region.	Proline	101-108	WASP actin nucleation promoting factor	Homo sapiens	76-80
16014383-6	2005	HOPS is a novel shuttling protein that contains an ubiquitin-like domain, a putative NES and a proline-rich region.	Proline	95-102	transmembrane and ubiquitin-like domain containing 1	Mus musculus	0-4
16000625-4	2005	We subsequently show that MAP2 is phosphorylated by JNK in intact cells and that MAP2 proline-rich domain phosphorylation is decreased in JNK1-/- brain.	Proline	86-93	microtubule-associated protein 2	Mus musculus	81-85
16000625-4	2005	We subsequently show that MAP2 is phosphorylated by JNK in intact cells and that MAP2 proline-rich domain phosphorylation is decreased in JNK1-/- brain.	Proline	86-93	mitogen-activated protein kinase 8	Mus musculus	138-142
15769254-5	2005	In the present study, we have identified three putative PEST (Pro, Glu, Ser/Thr-rich) sequences in RCP.	Proline	62-65	RAB11 family interacting protein 1	Homo sapiens	99-102
15907804-3	2005	We have also identified an hMSH5 polymorphism (C85T) [corrected] that altered codon 29 of the hMSH5 gene resulting in a proline-to-serine change (P29S).	Proline	120-127	mutS homolog 5	Homo sapiens	94-99
16002803-9	2005	RESULTS: Plasma insulin responses were higher by 299 +/- 64% and 132 +/- 63% in the CHO+PRO trial than in the CHO trial in the diabetic patients and the matched control subjects, respectively (P &lt; 0.001).	Proline	88-91	insulin	Homo sapiens	16-23
15907804-3	2005	We have also identified an hMSH5 polymorphism (C85T) [corrected] that altered codon 29 of the hMSH5 gene resulting in a proline-to-serine change (P29S).	Proline	120-127	mutS homolog 5	Homo sapiens	27-32
15962011-5	2005	The CIN85 SH3 domains A and C bind specifically to proline-arginine motifs present in Sprouty2.	Proline	51-58	sprouty RTK signaling antagonist 2	Rattus norvegicus	86-94
15866871-7	2005	We also show that PTP1B forms a complex with Src and p130(Cas), and that the proline-rich motif PPRPPK (residues 309-314) in PTP1B is essential for the complex formation.	Proline	77-84	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	53-57
15872073-9	2005	Mutations at the alpha-parvin N-terminal proline-directed serine phosphorylation sites reduced its complex formation with ILK and resulted in defects in podocyte adhesion, architecture, and survival.	Proline	41-48	parvin alpha	Homo sapiens	17-29
15872073-9	2005	Mutations at the alpha-parvin N-terminal proline-directed serine phosphorylation sites reduced its complex formation with ILK and resulted in defects in podocyte adhesion, architecture, and survival.	Proline	41-48	integrin linked kinase	Homo sapiens	122-125
16029324-1	2005	BACKGROUND: CDK5 is a member of proline-directed serine/threonine kinases.	Proline	32-39	cyclin dependent kinase 5	Homo sapiens	12-16
15703304-2	2005	The cytoplasmic domain of Siglec-7 contains two signaling motifs: a membrane-proximal immunoreceptor tyrosine-based inhibitory motif (ITIM) (Ile435-Gln-Tyr-Ala-Pro-Leu440) and a membrane-distal motif (Asn458-Glu-Tyr-Ser-Glu-Ile463).	Proline	160-163	sialic acid binding Ig like lectin 7	Homo sapiens	26-34
15866871-7	2005	We also show that PTP1B forms a complex with Src and p130(Cas), and that the proline-rich motif PPRPPK (residues 309-314) in PTP1B is essential for the complex formation.	Proline	77-84	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	125-130
15953370-0	2005	Proline mutations induce negative-dosage effects on uptake velocity of the dopamine transporter.	Proline	0-7	solute carrier family 6 member 3	Homo sapiens	75-95
15972656-0	2005	Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation.	Proline	125-132	torsin family 1 member A	Homo sapiens	79-82
15972656-5	2005	The alignment of the experimentally determined binding registers of nine gluten epitopes reveal positioning of proline residues in positions P1, P3, P6, and P8 but never in positions P2, P4, P7, and P9.	Proline	111-118	C-X9-C motif containing 4	Homo sapiens	145-159
15972658-0	2005	The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function.	Proline	15-22	CD3 antigen, epsilon polypeptide	Mus musculus	4-14
15972658-1	2005	The CD3epsilon proline-rich sequence (PRS) binds to the cytosolic adaptor molecule Nck after TCR ligation.	Proline	15-22	CD3 antigen, epsilon polypeptide	Mus musculus	4-14
15972658-1	2005	The CD3epsilon proline-rich sequence (PRS) binds to the cytosolic adaptor molecule Nck after TCR ligation.	Proline	15-22	non-catalytic region of tyrosine kinase adaptor protein 1	Mus musculus	83-86
15994821-2	2005	An analysis of the human genome demonstrated that ERV3 is one of a group of 41 highly related elements (ERV3-like HERVs) which use proline, isoleucine, or arginine tRNA in their primer binding sites.	Proline	131-138	endogenous retrovirus group 3 member 1, envelope	Homo sapiens	50-54
15994821-2	2005	An analysis of the human genome demonstrated that ERV3 is one of a group of 41 highly related elements (ERV3-like HERVs) which use proline, isoleucine, or arginine tRNA in their primer binding sites.	Proline	131-138	endogenous retrovirus group 3 member 1, envelope	Homo sapiens	104-108
15872089-5	2005	The association of dynamin with Cbl in osteoclasts was decreased by Src tyrosine kinase activity and we found that destabilization of the dynamin-Cbl complex involves the recruitment of Src through the proline-rich domain of Cbl.	Proline	202-209	Cbl proto-oncogene	Homo sapiens	146-149
15872089-5	2005	The association of dynamin with Cbl in osteoclasts was decreased by Src tyrosine kinase activity and we found that destabilization of the dynamin-Cbl complex involves the recruitment of Src through the proline-rich domain of Cbl.	Proline	202-209	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	186-189
15872089-5	2005	The association of dynamin with Cbl in osteoclasts was decreased by Src tyrosine kinase activity and we found that destabilization of the dynamin-Cbl complex involves the recruitment of Src through the proline-rich domain of Cbl.	Proline	202-209	Cbl proto-oncogene	Homo sapiens	146-149
15888547-12	2005	Cells expressing a mutant form of Shc with the four prolines substituted with alanines showed no Shc/SHPS-1 association in response to IGF-I.	Proline	52-60	SHC adaptor protein 1	Homo sapiens	34-37
15964795-0	2005	Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage.	Proline	13-20	tumor protein p53	Homo sapiens	27-30
15964795-0	2005	Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage.	Proline	13-20	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	56-60
15988003-5	2005	Strikingly, both phosphotyrosine-55 and proline-58 residues of TRIP6 are required for Crk binding in vitro and in cells.	Proline	40-47	thyroid hormone receptor interactor 6	Mus musculus	63-68
15964795-0	2005	Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage.	Proline	13-20	checkpoint kinase 2	Homo sapiens	65-69
15964795-5	2005	Proline 82 of p53 was identified to be essential for its interaction with the checkpoint kinase 2 (Chk2) and consequent phosphorylation of p53 on serine 20, following DNA damage.	Proline	0-7	tumor protein p53	Homo sapiens	14-17
15964795-5	2005	Proline 82 of p53 was identified to be essential for its interaction with the checkpoint kinase 2 (Chk2) and consequent phosphorylation of p53 on serine 20, following DNA damage.	Proline	0-7	checkpoint kinase 2	Homo sapiens	78-97
15964795-5	2005	Proline 82 of p53 was identified to be essential for its interaction with the checkpoint kinase 2 (Chk2) and consequent phosphorylation of p53 on serine 20, following DNA damage.	Proline	0-7	checkpoint kinase 2	Homo sapiens	99-103
15964795-5	2005	Proline 82 of p53 was identified to be essential for its interaction with the checkpoint kinase 2 (Chk2) and consequent phosphorylation of p53 on serine 20, following DNA damage.	Proline	0-7	tumor protein p53	Homo sapiens	139-142
15964795-6	2005	These physical and functional interactions are regulated by Pin1 through cis-trans isomerization of proline 82.	Proline	100-107	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	60-64
15988003-5	2005	Strikingly, both phosphotyrosine-55 and proline-58 residues of TRIP6 are required for Crk binding in vitro and in cells.	Proline	40-47	v-crk avian sarcoma virus CT10 oncogene homolog	Mus musculus	86-89
15998313-3	2005	lew2 mutant plants accumulated more abscisic acid (ABA), proline and soluble sugars than the wild type.	Proline	57-64	cellulose synthase family protein	Arabidopsis thaliana	0-4
15941409-6	2005	The Vrp1 HOT domain consists of three tandem proline-rich motifs flanked by serines.	Proline	45-52	Vrp1p	Saccharomyces cerevisiae S288C	4-8
16176095-3	2005	The thrombin cleavage site Arg156 in pro-UK was mutated into His156, and named as pro-UKM1; PAI binding sites Arg178, Arg179, Arg181 were mutated into Lys178, Lys179, His181, named as pro-UKM2; The mutant containing His156, Lys178, Lys179, His181 as pro-UKM3.	Proline	37-40	coagulation factor II, thrombin	Homo sapiens	4-12
16176095-3	2005	The thrombin cleavage site Arg156 in pro-UK was mutated into His156, and named as pro-UKM1; PAI binding sites Arg178, Arg179, Arg181 were mutated into Lys178, Lys179, His181, named as pro-UKM2; The mutant containing His156, Lys178, Lys179, His181 as pro-UKM3.	Proline	37-40	serpin family B member 2	Homo sapiens	92-95
16176095-3	2005	The thrombin cleavage site Arg156 in pro-UK was mutated into His156, and named as pro-UKM1; PAI binding sites Arg178, Arg179, Arg181 were mutated into Lys178, Lys179, His181, named as pro-UKM2; The mutant containing His156, Lys178, Lys179, His181 as pro-UKM3.	Proline	82-85	coagulation factor II, thrombin	Homo sapiens	4-12
16176095-3	2005	The thrombin cleavage site Arg156 in pro-UK was mutated into His156, and named as pro-UKM1; PAI binding sites Arg178, Arg179, Arg181 were mutated into Lys178, Lys179, His181, named as pro-UKM2; The mutant containing His156, Lys178, Lys179, His181 as pro-UKM3.	Proline	82-85	serpin family B member 2	Homo sapiens	92-95
15936902-8	2005	Regulation of BLNK recruitment was dependent upon the Grap2 proline-rich domain, while modulation of phosphorylation was dependent upon both the proline-rich and SH2 domains.	Proline	60-67	B cell linker	Mus musculus	14-18
15925329-1	2005	Dipeptidyl peptidase IV (DPP IV) is a ubiquitous membrane-bound enzyme that cleaves the two N-terminal amino acids from peptides with a proline or alanine residue in the second position from the amino end.	Proline	136-143	dipeptidylpeptidase 4	Mus musculus	0-23
15925329-1	2005	Dipeptidyl peptidase IV (DPP IV) is a ubiquitous membrane-bound enzyme that cleaves the two N-terminal amino acids from peptides with a proline or alanine residue in the second position from the amino end.	Proline	136-143	dipeptidylpeptidase 4	Mus musculus	25-31
15896958-1	2005	Conversion of the proline-derived cyanamide lead to an acyclic cyanamide capable of forming an additional hydrogen bond with cathepsin K resulted in a large increase in inhibitory activity.	Proline	18-25	cathepsin K	Rattus norvegicus	125-136
15922781-1	2005	Pyroglutamyl, proline-rich oligopeptides, classically referred to as bradykinin-potentiating peptides (BPPs) are found in Bothrops jararaca venom, and are naturally occurring inhibitors of the somatic angiotensin-converting enzyme (ACE).	Proline	14-21	angiotensin I converting enzyme	Homo sapiens	232-235
15944283-3	2005	Hinge length reduction by removal of two of the four C-terminal proline residues rendered IgA2-IgA1 half hinge resistant to all streptococcal IgA1 metalloproteinases but it remained sensitive to cleavage by the serine-type IgA1 proteases of Neisseria and Haemophilus spp.	Proline	64-71	immunoglobulin heavy constant alpha 1	Homo sapiens	95-99
15944283-3	2005	Hinge length reduction by removal of two of the four C-terminal proline residues rendered IgA2-IgA1 half hinge resistant to all streptococcal IgA1 metalloproteinases but it remained sensitive to cleavage by the serine-type IgA1 proteases of Neisseria and Haemophilus spp.	Proline	64-71	immunoglobulin heavy constant alpha 1	Homo sapiens	142-146
15944283-3	2005	Hinge length reduction by removal of two of the four C-terminal proline residues rendered IgA2-IgA1 half hinge resistant to all streptococcal IgA1 metalloproteinases but it remained sensitive to cleavage by the serine-type IgA1 proteases of Neisseria and Haemophilus spp.	Proline	64-71	immunoglobulin heavy constant alpha 1	Homo sapiens	142-146
15944398-3	2005	We recently identified a novel RhoGAP, BPGAP1, that uses the BNIP-2 and Cdc42GAP homology (BCH) domain, RhoGAP domain and proline-rich region to regulate cell morphology and migration.	Proline	122-129	Rho GTPase activating protein 8	Homo sapiens	39-45
15944398-6	2005	Pull-down and co-immunoprecipitation studies with deletion mutants confirmed that EEN interacted directly with BPGAP1 via its Src homology 3 (SH3) domain binding to the proline-rich region 182-PPPRPPLP-189 of BPGAP1, with prolines 184 and 186 being indispensable for this interaction.	Proline	169-176	SH3 domain containing GRB2 like 1, endophilin A2	Homo sapiens	82-85
15944398-6	2005	Pull-down and co-immunoprecipitation studies with deletion mutants confirmed that EEN interacted directly with BPGAP1 via its Src homology 3 (SH3) domain binding to the proline-rich region 182-PPPRPPLP-189 of BPGAP1, with prolines 184 and 186 being indispensable for this interaction.	Proline	169-176	Rho GTPase activating protein 8	Homo sapiens	111-117
15944398-6	2005	Pull-down and co-immunoprecipitation studies with deletion mutants confirmed that EEN interacted directly with BPGAP1 via its Src homology 3 (SH3) domain binding to the proline-rich region 182-PPPRPPLP-189 of BPGAP1, with prolines 184 and 186 being indispensable for this interaction.	Proline	222-230	SH3 domain containing GRB2 like 1, endophilin A2	Homo sapiens	82-85
15944398-6	2005	Pull-down and co-immunoprecipitation studies with deletion mutants confirmed that EEN interacted directly with BPGAP1 via its Src homology 3 (SH3) domain binding to the proline-rich region 182-PPPRPPLP-189 of BPGAP1, with prolines 184 and 186 being indispensable for this interaction.	Proline	222-230	Rho GTPase activating protein 8	Homo sapiens	111-117
15944398-11	2005	Our findings reveal a concomitant activation of endocytosis and ERK signaling by BPGAP1 via the coupling of its proline-rich region, which targets EEN and its functional GAP domain.	Proline	112-119	mitogen-activated protein kinase 3	Homo sapiens	64-67
15944398-11	2005	Our findings reveal a concomitant activation of endocytosis and ERK signaling by BPGAP1 via the coupling of its proline-rich region, which targets EEN and its functional GAP domain.	Proline	112-119	Rho GTPase activating protein 8	Homo sapiens	81-87
15944398-11	2005	Our findings reveal a concomitant activation of endocytosis and ERK signaling by BPGAP1 via the coupling of its proline-rich region, which targets EEN and its functional GAP domain.	Proline	112-119	SH3 domain containing GRB2 like 1, endophilin A2	Homo sapiens	147-150
15944403-2	2005	The transport block is due to the substitution of a glutamine by a proline at amino acid residue 1098 that generates a temperature-sensitive mutant enzyme, SI(Q1098P), the transport of which is regulated by several cycles of anterograde and retrograde transport between the ER and the cis-Golgi (Propsting, M. J., Jacob, R. and Naim, H. Y.	Proline	67-74	sucrase-isomaltase	Homo sapiens	156-158
15826939-1	2005	Integrin beta(3) is polymorphic at residue 33 (Leu(33) or Pro(33)), and the Pro(33)-positive platelets display enhanced aggregation, P-selectin secretion, and shorter bleeding times.	Proline	58-61	integrin subunit beta 3	Homo sapiens	0-16
15826939-1	2005	Integrin beta(3) is polymorphic at residue 33 (Leu(33) or Pro(33)), and the Pro(33)-positive platelets display enhanced aggregation, P-selectin secretion, and shorter bleeding times.	Proline	76-79	selectin P	Homo sapiens	133-143
15826953-0	2005	Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule.	Proline	56-63	torsin family 1 member A	Homo sapiens	122-125
15826953-4	2005	Preserving main chain hydrogen bond interactions despite the presence of multiple proline residues in gluten peptides is a key element for the HLA-DQ2 association of celiac disease.	Proline	82-89	torsin family 1 member A	Homo sapiens	147-150
15826939-3	2005	When compared with Pro(33)-negative platelets, Pro(33)-positive platelets demonstrated significantly greater serine/threonine phosphorylation of extracellular signal-regulated kinase (ERK2) and myosin light chain (MLC) but not cytoplasmic phospholipase A2 upon thrombin-induced aggregation.	Proline	47-50	mitogen-activated protein kinase 1	Homo sapiens	184-188
15826953-9	2005	This is a unique feature of DQ2 and is likely a key parameter for preferential binding of proline-rich gluten peptides and development of celiac disease.	Proline	90-97	torsin family 1 member A	Homo sapiens	28-31
15826939-3	2005	When compared with Pro(33)-negative platelets, Pro(33)-positive platelets demonstrated significantly greater serine/threonine phosphorylation of extracellular signal-regulated kinase (ERK2) and myosin light chain (MLC) but not cytoplasmic phospholipase A2 upon thrombin-induced aggregation.	Proline	47-50	phospholipase A2 group IB	Homo sapiens	239-255
15896459-1	2005	In this work, we described the proliferation of human non-small-cell-lung-cancer (NSCLC) cells H1437 harboring p53 alleles (proline-267) can be inhibited by low-dosage topoisomerase II inhibitor etoposide (VP-16) in vitro and in vivo.	Proline	124-131	host cell factor C1	Homo sapiens	206-211
15826939-3	2005	When compared with Pro(33)-negative platelets, Pro(33)-positive platelets demonstrated significantly greater serine/threonine phosphorylation of extracellular signal-regulated kinase (ERK2) and myosin light chain (MLC) but not cytoplasmic phospholipase A2 upon thrombin-induced aggregation.	Proline	47-50	coagulation factor II, thrombin	Homo sapiens	261-269
15784622-7	2005	ArgBP2gamma contains four Akt phosphorylation consensus sites, a SoHo motif, and three Src homology (SH) 3 domains and binds to C-terminal proline-rich motifs of Akt through its first and second SH3 domains.	Proline	139-146	AKT serine/threonine kinase 1	Homo sapiens	162-165
15896459-1	2005	In this work, we described the proliferation of human non-small-cell-lung-cancer (NSCLC) cells H1437 harboring p53 alleles (proline-267) can be inhibited by low-dosage topoisomerase II inhibitor etoposide (VP-16) in vitro and in vivo.	Proline	124-131	tumor protein p53	Homo sapiens	111-114
15788406-6	2005	Expression of truncated CCTalpha mutants lacking proline-directed sites within the C-terminal phosphorylation domain partially blocked oxysterol-mediated inhibition of PtdCho synthesis.	Proline	49-56	phosphate cytidylyltransferase 1A, choline	Homo sapiens	24-32
16024764-6	2005	Further, estradiol prevented okadaic acid-induced hyperphosphorylation of tau in both proline- and non-proline-directed sites, and antiestrogens blocked this effect.	Proline	86-93	microtubule associated protein tau	Homo sapiens	74-77
15932649-1	2005	BACKGROUND: Prolyl Endopeptidase (PEP, EC 3.4.21.26), a cytosolic endopeptidase, hydrolyses peptide bonds on the carboxyl side of proline residue in proteins with a relatively small molecular weight.	Proline	130-137	prolyl endopeptidase	Homo sapiens	12-32
15932649-1	2005	BACKGROUND: Prolyl Endopeptidase (PEP, EC 3.4.21.26), a cytosolic endopeptidase, hydrolyses peptide bonds on the carboxyl side of proline residue in proteins with a relatively small molecular weight.	Proline	130-137	prolyl endopeptidase	Homo sapiens	34-37
15677376-3	2005	Like CHAPS, domain peptide 4 (DP4, a synthetic peptide corresponding to the Leu(2442)-Pro(2477) region of RyR1), which seems to destabilize the interdomain interactions, markedly stimulated RyR1 but not RyR3.	Proline	86-89	transcription factor Dp family member 3	Homo sapiens	30-33
15677376-3	2005	Like CHAPS, domain peptide 4 (DP4, a synthetic peptide corresponding to the Leu(2442)-Pro(2477) region of RyR1), which seems to destabilize the interdomain interactions, markedly stimulated RyR1 but not RyR3.	Proline	86-89	ryanodine receptor 1	Homo sapiens	106-110
16024764-6	2005	Further, estradiol prevented okadaic acid-induced hyperphosphorylation of tau in both proline- and non-proline-directed sites, and antiestrogens blocked this effect.	Proline	103-110	microtubule associated protein tau	Homo sapiens	74-77
15933030-4	2005	Transcript level analysis revealed that among the five thiamine-pyrophospate-dependent decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3), only ARO10 was transcriptionally up-regulated when phenylalanine, leucine, or methionine was used as a nitrogen source compared to growth on ammonia, proline, and asparagine.	Proline	289-296	indolepyruvate decarboxylase 1	Saccharomyces cerevisiae S288C	103-107
15805167-2	2005	We substituted residue S1759 (serine), a putative D4S6 gating hinge of human cardiac hNav1.5 Na(+) channels with A (alanine), D (aspartate), K (lysine), L (leucine), P (proline), and W (tryptophan).	Proline	169-176	sodium voltage-gated channel alpha subunit 5	Homo sapiens	85-92
15933030-4	2005	Transcript level analysis revealed that among the five thiamine-pyrophospate-dependent decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3), only ARO10 was transcriptionally up-regulated when phenylalanine, leucine, or methionine was used as a nitrogen source compared to growth on ammonia, proline, and asparagine.	Proline	289-296	indolepyruvate decarboxylase 5	Saccharomyces cerevisiae S288C	109-113
15933030-4	2005	Transcript level analysis revealed that among the five thiamine-pyrophospate-dependent decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3), only ARO10 was transcriptionally up-regulated when phenylalanine, leucine, or methionine was used as a nitrogen source compared to growth on ammonia, proline, and asparagine.	Proline	289-296	indolepyruvate decarboxylase 6	Saccharomyces cerevisiae S288C	115-119
15933030-4	2005	Transcript level analysis revealed that among the five thiamine-pyrophospate-dependent decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3), only ARO10 was transcriptionally up-regulated when phenylalanine, leucine, or methionine was used as a nitrogen source compared to growth on ammonia, proline, and asparagine.	Proline	289-296	branched-chain-2-oxoacid decarboxylase THI3	Saccharomyces cerevisiae S288C	132-136
15933030-4	2005	Transcript level analysis revealed that among the five thiamine-pyrophospate-dependent decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3), only ARO10 was transcriptionally up-regulated when phenylalanine, leucine, or methionine was used as a nitrogen source compared to growth on ammonia, proline, and asparagine.	Proline	289-296	phenylpyruvate decarboxylase ARO10	Saccharomyces cerevisiae S288C	144-149
15882192-4	2005	The internalin-E-cadherin interaction is species-specific, and relies on the nature of a single amino-acid in the E-cadherin molecule, which is proline in permissive species such as humans, and glutamic acid in non-permissive species such as the mouse.	Proline	144-151	cadherin 1	Homo sapiens	15-25
15973048-0	2005	Engineering of yeast Put4 permease and its application to lager yeast for efficient proline assimilation.	Proline	84-91	proline permease PUT4	Saccharomyces cerevisiae S288C	21-25
15973048-1	2005	The Saccharomyces cerevisiae Put4 permease is significant for the transport of proline, alanine, and glycine.	Proline	79-86	proline permease PUT4	Saccharomyces cerevisiae S288C	29-33
15973048-6	2005	A lager yeast strain provided with Put4-20p was able to assimilate proline efficiently during beer fermentations.	Proline	67-74	proline permease PUT4	Saccharomyces cerevisiae S288C	35-39
15973048-7	2005	These results suggest possible industrial applications of the mutant Put4 permeases in improved fermentation systems for beer and other alcoholic beverages based on proline-rich fermentable sources.	Proline	165-172	proline permease PUT4	Saccharomyces cerevisiae S288C	69-73
15899386-2	2005	TP53 has two common polymorphic forms encoding either proline or arginine, at position 72, and the presence of homozygous arginine has been reported as a risk factor for cervical cancer in many populations.	Proline	54-61	tumor protein p53	Homo sapiens	0-4
15882192-4	2005	The internalin-E-cadherin interaction is species-specific, and relies on the nature of a single amino-acid in the E-cadherin molecule, which is proline in permissive species such as humans, and glutamic acid in non-permissive species such as the mouse.	Proline	144-151	cadherin 1	Homo sapiens	114-124
15561801-3	2005	NRC is a 2063-amino acid protein that harbors a potent N-terminal activation domain (AD1) and a second more centrally located activation domain (AD2) that is rich in Glu and Pro.	Proline	174-177	nuclear receptor coactivator 6	Mus musculus	0-3
15885111-0	2005	Combined solid-phase/solution synthesis of large ribonuclease A C-terminal peptides containing a non-natural proline analog.	Proline	109-116	ribonuclease pancreatic	Bos taurus	49-63
15977098-2	2005	The mitochondrial DNA (mtDNA) of this patient was examined and a C3310 T mutation was found in the ND1 gene, which resulted in the substitution of serine for proline.	Proline	158-165	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	99-102
15778087-5	2005	Data also show that beta-casein exhibits a higher chaperone-like activity than alpha-casein, likely due to the difference in the number of proline residues present and/or in the extent of exposed hydrophobic surfaces.	Proline	139-146	casein beta	Homo sapiens	20-31
15885111-3	2005	The main aim of this work was to incorporate sterically hindered l-5,5-dimethylproline (dmP) as a substitute for Pro(93) into the sequence of RNase A in order to constrain the -Tyr(92)-Pro(93)- peptide group to a single cis-conformation.	Proline	113-116	ribonuclease pancreatic	Bos taurus	142-149
15929994-3	2005	Under physiological conditions, Securin is devoid of tertiary and secondary structure except for a small amount of poly-(L-proline) type II helix and its hydrodynamic characteristics suggest it behaves as an extended polypeptide.	Proline	120-130	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	32-39
15923338-8	2005	The proline-rich domain (FH1) of the AtFH8 binds directly to profilin and is necessary for nucleation when actin monomers are profilin bound.	Proline	4-11	formin homology 1	Arabidopsis thaliana	25-28
15923338-8	2005	The proline-rich domain (FH1) of the AtFH8 binds directly to profilin and is necessary for nucleation when actin monomers are profilin bound.	Proline	4-11	formin 8	Arabidopsis thaliana	37-42
15923338-8	2005	The proline-rich domain (FH1) of the AtFH8 binds directly to profilin and is necessary for nucleation when actin monomers are profilin bound.	Proline	4-11	profilin	Arabidopsis thaliana	61-69
15923338-8	2005	The proline-rich domain (FH1) of the AtFH8 binds directly to profilin and is necessary for nucleation when actin monomers are profilin bound.	Proline	4-11	profilin	Arabidopsis thaliana	126-134
15911342-4	2005	We also assessed the localization of the Epidermal Growth Factor Receptor (EGFR), a basolateral protein whose sorting signal contains a proline-rich motif and two dihydrophobic motifs.	Proline	136-143	epidermal growth factor receptor	Canis lupus familiaris	41-73
15911342-4	2005	We also assessed the localization of the Epidermal Growth Factor Receptor (EGFR), a basolateral protein whose sorting signal contains a proline-rich motif and two dihydrophobic motifs.	Proline	136-143	epidermal growth factor receptor	Canis lupus familiaris	75-79
15631619-3	2005	The STNB protein contains a domain that has homology with the mu-subunit of the AP (adaptor protein) complex, as well as a number of NPF (Asp-Pro-Phe) motifs known to bind EH (Eps15 homology) domains.	Proline	142-145	stoned B	Drosophila melanogaster	4-8
15883377-9	2005	Scanning proline mutagenesis analysis shows that the Abeta molecule in these protofibrillar assemblies exhibits the same flexible N and C termini as do mature amyloid fibrils.	Proline	9-16	amyloid beta precursor protein	Homo sapiens	53-58
15789140-1	2005	We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats.	Proline	28-35	acetylcholinesterase	Rattus norvegicus	86-106
15735664-7	2005	Interestingly, cells expressing a mutant lacking the proline-rich domain of SHIP-2 at the C-terminal form few lamellipodia, but still spread and scatter upon stimulation with HGF at a reduced rate.	Proline	53-60	inositol polyphosphate phosphatase like 1	Homo sapiens	76-82
15735664-7	2005	Interestingly, cells expressing a mutant lacking the proline-rich domain of SHIP-2 at the C-terminal form few lamellipodia, but still spread and scatter upon stimulation with HGF at a reduced rate.	Proline	53-60	hepatocyte growth factor	Canis lupus familiaris	175-178
15878343-2	2005	In normoxia, HIF-1alpha subunits are hydroxylated on specific proline residues; modifications that signal ubiquitination and degradation of HIF-1alpha by the proteasome.	Proline	62-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
15878343-2	2005	In normoxia, HIF-1alpha subunits are hydroxylated on specific proline residues; modifications that signal ubiquitination and degradation of HIF-1alpha by the proteasome.	Proline	62-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-150
15538748-6	2005	Increased expression of the P582S mutant induced by iron chelation, which blocks proline hydroxylation of wild-type HIF-1alpha, was markedly attenuated.	Proline	81-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126
15789140-1	2005	We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats.	Proline	28-35	acetylcholinesterase	Rattus norvegicus	108-112
15789140-1	2005	We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats.	Proline	28-35	butyrylcholinesterase	Rattus norvegicus	167-188
15789140-1	2005	We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats.	Proline	28-35	butyrylcholinesterase	Rattus norvegicus	190-195
15789140-1	2005	We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats.	Proline	37-40	acetylcholinesterase	Rattus norvegicus	86-106
15789140-1	2005	We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats.	Proline	37-40	acetylcholinesterase	Rattus norvegicus	108-112
15789140-1	2005	We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats.	Proline	37-40	butyrylcholinesterase	Rattus norvegicus	167-188
15789140-1	2005	We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats.	Proline	37-40	butyrylcholinesterase	Rattus norvegicus	190-195
15888139-2	2005	A nonconservative Pro/Leu nucleotide polymorphism within PTCH exon 23 at codon 1315 was recently reported to be potentially important for the development of breast epithelial cell cancers.	Proline	18-21	patched 1	Homo sapiens	57-61
15845922-3	2005	SH2-B is a member of a conserved family of adapter proteins characterized by the presence of a C-terminal SH2 domain, a central pleckstrin homology (PH) domain, and an N-terminal proline rich region.	Proline	179-186	SH2B adaptor protein 1	Mus musculus	0-5
15888189-0	2005	A novel threonine to proline mutation in the helix termination motif of keratin 1 in epidermolytic hyperkeratosis with severe palmoplantar hyperkeratosis and contractures of the digits.	Proline	21-28	keratin 1	Homo sapiens	72-81
15827961-4	2005	TSAd contains a Src homology (SH)2 domain, ten tyrosines and a C-terminal proline-rich region.	Proline	74-81	SH2 domain containing 2A	Homo sapiens	0-4
15827961-6	2005	The TSAd C terminus, including the proline-rich region and five tyrosines, is both necessary and sufficient for TSAd interaction with and phosphorylation by Lck.	Proline	35-42	SH2 domain containing 2A	Homo sapiens	4-8
15827961-6	2005	The TSAd C terminus, including the proline-rich region and five tyrosines, is both necessary and sufficient for TSAd interaction with and phosphorylation by Lck.	Proline	35-42	SH2 domain containing 2A	Homo sapiens	112-116
15827961-6	2005	The TSAd C terminus, including the proline-rich region and five tyrosines, is both necessary and sufficient for TSAd interaction with and phosphorylation by Lck.	Proline	35-42	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	157-160
15885096-5	2005	The periodic positioning of proline residues in XPCB-hHR23B produced kinked alpha helices and assisted in the formation of a compact domain.	Proline	28-35	RAD23 homolog B, nucleotide excision repair protein	Homo sapiens	53-59
15966238-0	2005	Arginine and proline alleles of the p53 gene are associated with different locations of gastric cancer.	Proline	13-20	tumor protein p53	Homo sapiens	36-39
15966238-14	2005	CONCLUSIONS: The proline allele at p53 codon 72 is associated with adenocarcinoma of the gastric cardia, and the arginine allele is associated with cancer of the antral and corpus locations.	Proline	17-24	tumor protein p53	Homo sapiens	35-38
15841212-1	2005	Synaptopodin is the founding member of a novel class of proline-rich actin-associated proteins highly expressed in telencephalic dendrites and renal podocytes.	Proline	56-63	synaptopodin	Mus musculus	0-12
15845513-8	2005	The second type of mutation involved at least four nonsynonymous nucleotide changes, but only the replacement of proline with serine at CdtB position 95 was considered important for CDT activity.	Proline	113-120	corneal dystrophy of Bowman's layer type II (Thiel-Behnke)	Homo sapiens	136-140
15770651-1	2005	Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) is a hematopoietic-specific mammalian STE20-like protein serine/threonine kinase, comprised of a STE20-like kinase domain in its N-terminus, four proline-rich motifs, a caspase cleavage site, and a distal C-terminal Citron homology domain.	Proline	197-204	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	0-33
15770651-1	2005	Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) is a hematopoietic-specific mammalian STE20-like protein serine/threonine kinase, comprised of a STE20-like kinase domain in its N-terminus, four proline-rich motifs, a caspase cleavage site, and a distal C-terminal Citron homology domain.	Proline	197-204	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	35-39
15770651-1	2005	Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) is a hematopoietic-specific mammalian STE20-like protein serine/threonine kinase, comprised of a STE20-like kinase domain in its N-terminus, four proline-rich motifs, a caspase cleavage site, and a distal C-terminal Citron homology domain.	Proline	197-204	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	43-49
15811554-3	2005	Results showed that treatment with Vitamins E and C prevented the alterations caused by acute and chronic administration of proline on chemiluminescence, total radical-trapping antioxidant potential (TRAP) and on the activities of catalase and glutathione peroxidase.	Proline	124-131	catalase	Homo sapiens	231-239
15821731-4	2005	EphB2 causes tyrosine phosphorylation in the proline-rich domain of synaptojanin 1, and inhibits both the interaction with endophilin and the 5"-phosphatase activity of synaptojanin 1.	Proline	45-52	EPH receptor B2	Homo sapiens	0-5
15867923-2	2005	By catalysing cis-trans interconversion of certain motifs containing phosphorylated serine or threonine residues followed by a proline residue (pSer/Thr-Pro), Pin1 can have profound effects on phosphorylation signalling.	Proline	127-134	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	159-163
15867923-2	2005	By catalysing cis-trans interconversion of certain motifs containing phosphorylated serine or threonine residues followed by a proline residue (pSer/Thr-Pro), Pin1 can have profound effects on phosphorylation signalling.	Proline	153-156	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	159-163
15811383-7	2005	This interaction appears to be mediated by the proline-arginine-rich domain (PRD) of Dyn2, as a GST-PRD fragment binds Cav1 while GST-Dyn2DeltaPRD does not.	Proline	47-54	dynamin 2	Homo sapiens	85-89
15723349-6	2005	This is induced by the replacement of a conserved Asp, Asn, or Glu residue by a Pro at one side of the N-Src loop.	Proline	80-83	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-108
15942925-1	2005	The acidic-rich activation domain of VP16 and the proline-rich activation domains of human AP2 and human CTF are able to activate transcription in a whole cell extract from Schizosaccharomyces pombe, whereas the glutamine-rich domains of Sp1 and Oct2 are unable to activate transcription in this system.	Proline	50-57	transcription factor AP-2 alpha	Homo sapiens	91-94
15942925-1	2005	The acidic-rich activation domain of VP16 and the proline-rich activation domains of human AP2 and human CTF are able to activate transcription in a whole cell extract from Schizosaccharomyces pombe, whereas the glutamine-rich domains of Sp1 and Oct2 are unable to activate transcription in this system.	Proline	50-57	establishment of sister chromatid cohesion N-acetyltransferase 1	Homo sapiens	105-108
15671024-0	2005	Regulation of CD147 cell surface expression: involvement of the proline residue in the CD147 transmembrane domain.	Proline	64-71	basigin (Ok blood group)	Homo sapiens	14-19
15671024-0	2005	Regulation of CD147 cell surface expression: involvement of the proline residue in the CD147 transmembrane domain.	Proline	64-71	basigin (Ok blood group)	Homo sapiens	87-92
15671024-5	2005	Peptide binding studies demonstrated specific interaction between CypA and the proline-containing peptide from the CD147 transmembrane domain.	Proline	79-86	peptidylprolyl isomerase A	Homo sapiens	66-70
15671024-5	2005	Peptide binding studies demonstrated specific interaction between CypA and the proline-containing peptide from the CD147 transmembrane domain.	Proline	79-86	basigin (Ok blood group)	Homo sapiens	115-120
15671024-6	2005	Mutation of this proline residue reduced binding of CD147-derived peptides to CypA and also diminished transport of CD147 to the plasma membrane without reducing the total level of CD147 expression.	Proline	17-24	basigin (Ok blood group)	Homo sapiens	52-57
15671024-6	2005	Mutation of this proline residue reduced binding of CD147-derived peptides to CypA and also diminished transport of CD147 to the plasma membrane without reducing the total level of CD147 expression.	Proline	17-24	peptidylprolyl isomerase A	Homo sapiens	78-82
15671024-6	2005	Mutation of this proline residue reduced binding of CD147-derived peptides to CypA and also diminished transport of CD147 to the plasma membrane without reducing the total level of CD147 expression.	Proline	17-24	basigin (Ok blood group)	Homo sapiens	116-121
15671024-6	2005	Mutation of this proline residue reduced binding of CD147-derived peptides to CypA and also diminished transport of CD147 to the plasma membrane without reducing the total level of CD147 expression.	Proline	17-24	basigin (Ok blood group)	Homo sapiens	116-121
15821731-4	2005	EphB2 causes tyrosine phosphorylation in the proline-rich domain of synaptojanin 1, and inhibits both the interaction with endophilin and the 5"-phosphatase activity of synaptojanin 1.	Proline	45-52	synaptojanin 1	Homo sapiens	68-82
16128105-6	2005	The p53 Pro/Pro genotype significantly increased the risk for developing keloid, compared to the combination of Pro/Arg and Arg/Arg genotypes,with the odds ratio (OR) of 2.400 (95%CI: 1.048-5.498).	Proline	8-11	tumor protein p53	Homo sapiens	4-7
15811383-7	2005	This interaction appears to be mediated by the proline-arginine-rich domain (PRD) of Dyn2, as a GST-PRD fragment binds Cav1 while GST-Dyn2DeltaPRD does not.	Proline	47-54	caveolin 1	Homo sapiens	119-123
15828845-4	2005	The most notable results include the identification that modification of the chimeric template at the His position with Pro and Phe resulted in ligands that were nM mouse melanocortin-3 receptor (mMC3R) antagonists and nM mouse melanocortin-4 receptor (mMC4R) agonists.	Proline	120-123	melanocortin 3 receptor	Mus musculus	171-194
15808862-5	2005	Pim1 is unique among protein kinases due to the presence of a proline residue at position 123 that precludes the formation of the canonical second hydrogen bond between the hinge backbone and the adenine moiety of ATP.	Proline	62-69	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
15828845-4	2005	The most notable results include the identification that modification of the chimeric template at the His position with Pro and Phe resulted in ligands that were nM mouse melanocortin-3 receptor (mMC3R) antagonists and nM mouse melanocortin-4 receptor (mMC4R) agonists.	Proline	120-123	melanocortin 4 receptor	Mus musculus	228-251
15696600-4	2005	Prolidase also provides free proline as substrate for proline oxidase, whose gene is activated by p53 during apoptosis.	Proline	29-36	cellular tumor antigen p53	Cricetulus griseus	98-101
15632207-4	2005	DNA sequence analysis of the fibrinogen genes A, B, and G revealed a T&gt;C transition in exon 9 resulting in a serine-to-proline substitution near the gamma chain C-terminus (S378P).	Proline	122-129	fibrinogen beta chain	Homo sapiens	29-39
15752768-0	2005	Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.	Proline	88-95	calcium binding tyrosine phosphorylation regulated	Homo sapiens	44-49
15752768-0	2005	Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.	Proline	88-95	glycogen synthase kinase 3 beta	Homo sapiens	72-80
15752768-3	2005	Molecular characterization showed that CABYR variants formed a dimer with a proline-rich extensin-like domain, which slightly overlapped with GSK3beta-binding site.	Proline	76-83	calcium binding tyrosine phosphorylation regulated	Homo sapiens	39-44
15752768-3	2005	Molecular characterization showed that CABYR variants formed a dimer with a proline-rich extensin-like domain, which slightly overlapped with GSK3beta-binding site.	Proline	76-83	glycogen synthase kinase 3 beta	Homo sapiens	142-150
15784259-1	2005	The Crk-associated tyrosine kinase substrate p130cas (CAS) is a docking protein containing an SH3 domain near its N terminus, followed by a short proline-rich segment, a large central substrate domain composed of 15 repeats of the four amino acid sequence YxxP, a serine-rich region and a carboxy-terminal domain, which possesses consensus binding sites for the SH2 and SH3 domains of Src (YDYV and RPLPSPP, respectively).	Proline	146-153	BCAR1 scaffold protein, Cas family member	Homo sapiens	45-52
15774859-7	2005	An important role for these cTnT sites is indicated by results demonstrating that ROCK-II induced a depression in tension and ATPase activity in skinned fiber bundles from a TG model in which cTnI is replaced by slow skeletal TnI, which lacks S23 and S24 and in which T144 is replaced by proline.	Proline	288-295	troponin T2, cardiac	Mus musculus	28-32
15774859-7	2005	An important role for these cTnT sites is indicated by results demonstrating that ROCK-II induced a depression in tension and ATPase activity in skinned fiber bundles from a TG model in which cTnI is replaced by slow skeletal TnI, which lacks S23 and S24 and in which T144 is replaced by proline.	Proline	288-295	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	82-89
15784259-1	2005	The Crk-associated tyrosine kinase substrate p130cas (CAS) is a docking protein containing an SH3 domain near its N terminus, followed by a short proline-rich segment, a large central substrate domain composed of 15 repeats of the four amino acid sequence YxxP, a serine-rich region and a carboxy-terminal domain, which possesses consensus binding sites for the SH2 and SH3 domains of Src (YDYV and RPLPSPP, respectively).	Proline	146-153	BCAR1 scaffold protein, Cas family member	Homo sapiens	54-57
15784259-3	2005	As a homolog of the corresponding Src docking domain, the CAS SH3 domain binds to proline-rich sequences (PxxP) of its interacting partners that can adopt a polyproline type II helix.	Proline	82-89	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	34-37
15784259-3	2005	As a homolog of the corresponding Src docking domain, the CAS SH3 domain binds to proline-rich sequences (PxxP) of its interacting partners that can adopt a polyproline type II helix.	Proline	82-89	BCAR1 scaffold protein, Cas family member	Homo sapiens	58-61
15799735-3	2005	RESULTS: Two molecular defects found in the NDP gene were: a missense mutation (265C > G) within codon 97 that resulted in the interchange of arginine by proline, and a partial deletion in the untranslated 3" region of exon 3 of the NDP gene.	Proline	154-161	norrin cystine knot growth factor NDP	Homo sapiens	44-47
15657040-9	2005	Here we report the crystal structures of SH3p40 alone or in complex with a 12-residue proline-rich region of p47phox at 1.46 angstrom resolution.	Proline	86-93	neutrophil cytosolic factor 1	Homo sapiens	109-116
15737607-3	2005	Human cathepsin X has broad S2, S1, and S1" specificities within two orders of magnitude in k(cat)/K(M), excluding proline that is not tolerated at these subsites.	Proline	115-122	cathepsin Z	Homo sapiens	6-17
15771721-1	2005	A single nucleotide polymorphism (SNP) in the corticotrophin-releasing hormone gene (CRH C22G) alters the fourth amino acid in the signal sequence from proline to arginine.	Proline	152-159	corticotropin releasing hormone	Bos taurus	85-88
15653747-3	2005	The validity of the apoB model was supported by conservation of disulfide bonds, location of all proline residues in turns and loops, and conservation of the hydrophobic faces of the two C-terminal amphipathic beta-sheets, betaA (residues 600-763) and betaB (residues 780-1000).	Proline	97-104	apolipoprotein B	Homo sapiens	20-24
15814626-0	2005	The p53 codon 72 proline allele is associated with p53 gene mutations in non-small cell lung cancer.	Proline	17-24	tumor protein p53	Homo sapiens	4-7
15840119-0	2005	A severe case of pachyonychia congenita type I due to a novel proline mutation in keratin 6a.	Proline	62-69	keratin 6A	Homo sapiens	82-92
15814626-0	2005	The p53 codon 72 proline allele is associated with p53 gene mutations in non-small cell lung cancer.	Proline	17-24	tumor protein p53	Homo sapiens	51-54
15966514-6	2005	The mutation is a replacement of cytosine for guanine in codon 453 (CCT-&gt;GCT) producing a missense mutation substituting a normal proline with an alanine (P453A), which reduces the affinity for T3 to 17% of that of the normal TRbeta.	Proline	133-140	T cell receptor beta locus	Homo sapiens	229-235
15811717-3	2005	This missense mutation, causing amino acid leucine at position 205 to be substituted by proline, is located in the highly conserved sequence of the fourth transmembrane domain (TM4) of Cx26.	Proline	88-95	gap junction protein beta 2	Homo sapiens	185-189
15807871-0	2005	Novel missense mutations, GCC [Ala306]- &gt; GTC [Val] and ACG [Thr318]- &gt; CCG [Pro], in the CYP11B1 gene cause steroid 11beta-hydroxylase deficiency in the Chinese.	Proline	83-86	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	96-103
15798179-1	2005	The human progesterone receptor (PR) contains multiple Ser-Pro phosphorylation sites that are potential substrates for cyclin-dependent kinases, suggesting that PR activity might be regulated during the cell cycle.	Proline	59-62	progesterone receptor	Homo sapiens	10-31
15798179-1	2005	The human progesterone receptor (PR) contains multiple Ser-Pro phosphorylation sites that are potential substrates for cyclin-dependent kinases, suggesting that PR activity might be regulated during the cell cycle.	Proline	59-62	progesterone receptor	Homo sapiens	33-35
15781195-9	2005	Adiponectin was significantly higher (p&lt;0.05) in subjects who simultaneously had the Ala/Ala (PPARgamma2)+Gly/Gly (IRS-1) genotype combination compared to subjects with the Pro/Pro+Gly/Gly and Pro/Ala+Gly/Gly genotype combinations.	Proline	176-179	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
15798179-1	2005	The human progesterone receptor (PR) contains multiple Ser-Pro phosphorylation sites that are potential substrates for cyclin-dependent kinases, suggesting that PR activity might be regulated during the cell cycle.	Proline	59-62	progesterone receptor	Homo sapiens	161-163
15781195-9	2005	Adiponectin was significantly higher (p&lt;0.05) in subjects who simultaneously had the Ala/Ala (PPARgamma2)+Gly/Gly (IRS-1) genotype combination compared to subjects with the Pro/Pro+Gly/Gly and Pro/Ala+Gly/Gly genotype combinations.	Proline	180-183	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
15798181-5	2005	Consistent with this, the SH3 domain-containing protein Abp1 physically associates with Sjl2 through its proline-rich domain.	Proline	105-112	Abp1p	Saccharomyces cerevisiae S288C	56-60
15798181-5	2005	Consistent with this, the SH3 domain-containing protein Abp1 physically associates with Sjl2 through its proline-rich domain.	Proline	105-112	phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52	Saccharomyces cerevisiae S288C	88-92
16076020-1	2005	We investigated the action of the new hypothalamic proline-rich peptide (PRP-1), normally produced by neurosecretory cells of hypothalamic nuclei (NPV and NSO), 3 and 4 weeks following rat sciatic nerve transection.	Proline	51-58	tumor-associated calcium signal transducer 2	Rattus norvegicus	73-78
15632178-7	2005	Immediately following the kinase domain in Abl is a proline-rich linker (PRL) that binds to several SH3 adaptor proteins.	Proline	52-59	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	43-46
15796781-14	2005	We conclude that Iporin might function as a link between the targeting of ER derived vesicles, triggered by the rab1 GTPase and a signaling pathway regulated by molecules containing SH3 and/or poly-proline regions.	Proline	198-205	RUN and SH3 domain containing 2	Homo sapiens	17-23
15590655-3	2005	The translocation of Bax to mitochondria is associated with specific changes in the conformation of the protein that are under the control of two prolines: Pro-13, which controls the unfolding of halpha1, and Pro-168, a proline located immediately before the hydrophobic carboxyl-terminal end (i.e. helix alpha9, halpha9), which controls the disclosure of halpha5alpha6.	Proline	146-153	BCL2 associated X, apoptosis regulator	Homo sapiens	21-24
15753298-5	2005	We found that the osteocalcin sequences of Neanderthals, modern human, chimpanzee, and orangutan are unusual among mammals in that the ninth amino acid is proline (Pro-9), whereas most species have hydroxyproline (Hyp-9).	Proline	155-162	bone gamma-carboxyglutamate protein	Pan troglodytes	18-29
15753298-5	2005	We found that the osteocalcin sequences of Neanderthals, modern human, chimpanzee, and orangutan are unusual among mammals in that the ninth amino acid is proline (Pro-9), whereas most species have hydroxyproline (Hyp-9).	Proline	164-167	bone gamma-carboxyglutamate protein	Pan troglodytes	18-29
15753298-6	2005	Posttranslational hydroxylation of Pro-9 in osteocalcin by prolyl-4-hydroxylase requires adequate concentrations of vitamin C (l-ascorbic acid), molecular O(2), Fe(2+), and 2-oxoglutarate, and also depends on enzyme recognition of the target proline substrate consensus sequence Leu-Gly-Ala-Pro-9-Ala-Pro-Tyr occurring in most mammals.	Proline	242-249	bone gamma-carboxyglutamate protein	Pan troglodytes	44-55
15647258-4	2005	A comparison of the disulfide structure of the reactants with the known disulfide structure of the PAPP-A.pro-MBP complex reveals that six cysteine residues of the pro-MBP subunit (Cys-51, Cys-89, Cys-104, Cys-107, Cys-128, and Cys-169) and two cysteine residues of the PAPP-A subunit (Cys-381 and Cys-652) change their status from the uncomplexed to the complexed states.	Proline	106-109	pappalysin 1	Homo sapiens	99-105
15647260-0	2005	Exceptional disfavor for proline at the P + 1 position among AGC and CAMK kinases establishes reciprocal specificity between them and the proline-directed kinases.	Proline	25-32	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	69-73
15598660-4	2005	Interestingly, in the human CD80-CD152 complex, Pro(102) of CD152 restricts the preceding proline to PP(II) helix in the binding orientation in relation to the shallow binding pocket of CD80.	Proline	48-51	CD80 molecule	Homo sapiens	28-32
15598660-4	2005	Interestingly, in the human CD80-CD152 complex, Pro(102) of CD152 restricts the preceding proline to PP(II) helix in the binding orientation in relation to the shallow binding pocket of CD80.	Proline	48-51	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	33-38
15598660-4	2005	Interestingly, in the human CD80-CD152 complex, Pro(102) of CD152 restricts the preceding proline to PP(II) helix in the binding orientation in relation to the shallow binding pocket of CD80.	Proline	48-51	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	60-65
15598660-4	2005	Interestingly, in the human CD80-CD152 complex, Pro(102) of CD152 restricts the preceding proline to PP(II) helix in the binding orientation in relation to the shallow binding pocket of CD80.	Proline	48-51	CD80 molecule	Homo sapiens	186-190
15598660-4	2005	Interestingly, in the human CD80-CD152 complex, Pro(102) of CD152 restricts the preceding proline to PP(II) helix in the binding orientation in relation to the shallow binding pocket of CD80.	Proline	90-97	CD80 molecule	Homo sapiens	28-32
15598660-4	2005	Interestingly, in the human CD80-CD152 complex, Pro(102) of CD152 restricts the preceding proline to PP(II) helix in the binding orientation in relation to the shallow binding pocket of CD80.	Proline	90-97	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	33-38
15598660-4	2005	Interestingly, in the human CD80-CD152 complex, Pro(102) of CD152 restricts the preceding proline to PP(II) helix in the binding orientation in relation to the shallow binding pocket of CD80.	Proline	90-97	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	60-65
15598660-4	2005	Interestingly, in the human CD80-CD152 complex, Pro(102) of CD152 restricts the preceding proline to PP(II) helix in the binding orientation in relation to the shallow binding pocket of CD80.	Proline	90-97	CD80 molecule	Homo sapiens	186-190
15647260-4	2005	Analysis of degenerate and non-degenerate peptides by in vitro kinase assays reveals that proline at the P + 1 position in substrates functions as a "veto" residue in substrate recognition by AGC and CAMK kinases.	Proline	90-97	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	200-204
15647258-4	2005	A comparison of the disulfide structure of the reactants with the known disulfide structure of the PAPP-A.pro-MBP complex reveals that six cysteine residues of the pro-MBP subunit (Cys-51, Cys-89, Cys-104, Cys-107, Cys-128, and Cys-169) and two cysteine residues of the PAPP-A subunit (Cys-381 and Cys-652) change their status from the uncomplexed to the complexed states.	Proline	106-109	myelin basic protein	Homo sapiens	110-113
15689184-4	2005	Expression of mouse XT3s1, but not XT3, in Xenopus laevis oocytes induced an electrogenic Na+-and-Cl--dependent transporter for proline, hydroxyproline, betaine, N-methylaminoisobutyric acid and pipecolic acid.	Proline	128-135	solute carrier family 6 (neurotransmitter transporter), member 20A	Mus musculus	20-25
15688017-10	2005	In contrast, deletion of an MIM proline-rich domain, which is required for an optimal binding to cortactin, substantiated the MIM-mediated inhibition of cell motility.	Proline	32-39	MTSS I-BAR domain containing 1	Mus musculus	28-31
15688017-10	2005	In contrast, deletion of an MIM proline-rich domain, which is required for an optimal binding to cortactin, substantiated the MIM-mediated inhibition of cell motility.	Proline	32-39	cortactin	Mus musculus	97-106
15688017-10	2005	In contrast, deletion of an MIM proline-rich domain, which is required for an optimal binding to cortactin, substantiated the MIM-mediated inhibition of cell motility.	Proline	32-39	MTSS I-BAR domain containing 1	Mus musculus	126-129
15708373-1	2005	Aminopeptidase P (APP) isoforms specifically remove the N-terminal amino acid from peptides that have a proline residue in the second position.	Proline	104-111	amyloid beta precursor protein	Homo sapiens	0-16
15689184-4	2005	Expression of mouse XT3s1, but not XT3, in Xenopus laevis oocytes induced an electrogenic Na+-and-Cl--dependent transporter for proline, hydroxyproline, betaine, N-methylaminoisobutyric acid and pipecolic acid.	Proline	128-135	solute carrier family 6 (neurotransmitter transporter), member 20B	Mus musculus	20-23
15632147-5	2005	When expressed in Xenopus oocytes, rat SIT1 mediated the uptake of imino acids such as proline (K0.5 approximately 0.2 mM) and pipecolate, as well as N-methylated amino acids (e.g. MeAIB, sarcosine).	Proline	87-94	solute carrier family 6 member 20	Homo sapiens	39-43
15632147-6	2005	SIT1-mediated proline transport was pH-independent and insensitive to inhibition by alanine or lysine.	Proline	14-21	solute carrier family 6 member 20	Homo sapiens	0-4
15632147-13	2005	We found that SIT1 was dramatically up-regulated in the kidneys of 3-day-old mice, accounting for the maturation of proline reabsorption in the mouse.	Proline	116-123	solute carrier family 6 member 20	Homo sapiens	14-18
15637062-3	2005	Here, we show that the proline-rich domain of PRAM-1 interacted with the Src homology 3 (SH3) domain of hematopoietic progenitor kinase 1 (HPK-1)-interacting protein of 55 kDa (HIP-55, also called SH3P7 and Abp1) known to stimulate the activity of HPK-1 and c-Jun N-terminal kinase (JNK).	Proline	23-30	PML-RARA regulated adaptor molecule 1	Homo sapiens	46-52
15637062-3	2005	Here, we show that the proline-rich domain of PRAM-1 interacted with the Src homology 3 (SH3) domain of hematopoietic progenitor kinase 1 (HPK-1)-interacting protein of 55 kDa (HIP-55, also called SH3P7 and Abp1) known to stimulate the activity of HPK-1 and c-Jun N-terminal kinase (JNK).	Proline	23-30	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	104-137
15637062-3	2005	Here, we show that the proline-rich domain of PRAM-1 interacted with the Src homology 3 (SH3) domain of hematopoietic progenitor kinase 1 (HPK-1)-interacting protein of 55 kDa (HIP-55, also called SH3P7 and Abp1) known to stimulate the activity of HPK-1 and c-Jun N-terminal kinase (JNK).	Proline	23-30	drebrin like	Homo sapiens	139-175
15637062-3	2005	Here, we show that the proline-rich domain of PRAM-1 interacted with the Src homology 3 (SH3) domain of hematopoietic progenitor kinase 1 (HPK-1)-interacting protein of 55 kDa (HIP-55, also called SH3P7 and Abp1) known to stimulate the activity of HPK-1 and c-Jun N-terminal kinase (JNK).	Proline	23-30	drebrin like	Homo sapiens	177-183
15637062-3	2005	Here, we show that the proline-rich domain of PRAM-1 interacted with the Src homology 3 (SH3) domain of hematopoietic progenitor kinase 1 (HPK-1)-interacting protein of 55 kDa (HIP-55, also called SH3P7 and Abp1) known to stimulate the activity of HPK-1 and c-Jun N-terminal kinase (JNK).	Proline	23-30	drebrin like	Homo sapiens	197-202
15694388-3	2005	TLR4 and TLR4/2a chimera consisting of the TLR4 region Met(1)-Phe(54) and the TLR2 region Ala(53)-Ser(784) were coprecipitated with MD-2, but the deletion mutant TLR4(Delta E24-P34) in which the TLR4 region Glu(24)-Pro(34) was deleted failed to coprecipitate.	Proline	215-218	toll like receptor 4	Homo sapiens	0-4
15637062-3	2005	Here, we show that the proline-rich domain of PRAM-1 interacted with the Src homology 3 (SH3) domain of hematopoietic progenitor kinase 1 (HPK-1)-interacting protein of 55 kDa (HIP-55, also called SH3P7 and Abp1) known to stimulate the activity of HPK-1 and c-Jun N-terminal kinase (JNK).	Proline	23-30	drebrin like	Homo sapiens	207-211
15637062-3	2005	Here, we show that the proline-rich domain of PRAM-1 interacted with the Src homology 3 (SH3) domain of hematopoietic progenitor kinase 1 (HPK-1)-interacting protein of 55 kDa (HIP-55, also called SH3P7 and Abp1) known to stimulate the activity of HPK-1 and c-Jun N-terminal kinase (JNK).	Proline	23-30	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	139-144
15637062-3	2005	Here, we show that the proline-rich domain of PRAM-1 interacted with the Src homology 3 (SH3) domain of hematopoietic progenitor kinase 1 (HPK-1)-interacting protein of 55 kDa (HIP-55, also called SH3P7 and Abp1) known to stimulate the activity of HPK-1 and c-Jun N-terminal kinase (JNK).	Proline	23-30	mitogen-activated protein kinase 8	Homo sapiens	258-281
15637062-3	2005	Here, we show that the proline-rich domain of PRAM-1 interacted with the Src homology 3 (SH3) domain of hematopoietic progenitor kinase 1 (HPK-1)-interacting protein of 55 kDa (HIP-55, also called SH3P7 and Abp1) known to stimulate the activity of HPK-1 and c-Jun N-terminal kinase (JNK).	Proline	23-30	mitogen-activated protein kinase 8	Homo sapiens	283-286
15694388-3	2005	TLR4 and TLR4/2a chimera consisting of the TLR4 region Met(1)-Phe(54) and the TLR2 region Ala(53)-Ser(784) were coprecipitated with MD-2, but the deletion mutant TLR4(Delta E24-P34) in which the TLR4 region Glu(24)-Pro(34) was deleted failed to coprecipitate.	Proline	215-218	toll like receptor 4	Homo sapiens	9-13
15694388-3	2005	TLR4 and TLR4/2a chimera consisting of the TLR4 region Met(1)-Phe(54) and the TLR2 region Ala(53)-Ser(784) were coprecipitated with MD-2, but the deletion mutant TLR4(Delta E24-P34) in which the TLR4 region Glu(24)-Pro(34) was deleted failed to coprecipitate.	Proline	215-218	toll like receptor 4	Homo sapiens	9-13
15694388-3	2005	TLR4 and TLR4/2a chimera consisting of the TLR4 region Met(1)-Phe(54) and the TLR2 region Ala(53)-Ser(784) were coprecipitated with MD-2, but the deletion mutant TLR4(Delta E24-P34) in which the TLR4 region Glu(24)-Pro(34) was deleted failed to coprecipitate.	Proline	215-218	toll like receptor 2	Homo sapiens	78-82
15694388-3	2005	TLR4 and TLR4/2a chimera consisting of the TLR4 region Met(1)-Phe(54) and the TLR2 region Ala(53)-Ser(784) were coprecipitated with MD-2, but the deletion mutant TLR4(Delta E24-P34) in which the TLR4 region Glu(24)-Pro(34) was deleted failed to coprecipitate.	Proline	215-218	toll like receptor 4	Homo sapiens	9-13
15694388-3	2005	TLR4 and TLR4/2a chimera consisting of the TLR4 region Met(1)-Phe(54) and the TLR2 region Ala(53)-Ser(784) were coprecipitated with MD-2, but the deletion mutant TLR4(Delta E24-P34) in which the TLR4 region Glu(24)-Pro(34) was deleted failed to coprecipitate.	Proline	215-218	toll like receptor 4	Homo sapiens	9-13
15694388-7	2005	These results clearly demonstrate that the amino-terminal TLR4 region of Glu(24)-Pro(34) is critical for MD-2 binding and LPS signaling.	Proline	81-84	toll like receptor 4	Homo sapiens	58-62
15615722-4	2005	On the one hand, it supports intercellular adhesion molecule 1 (ICAM-1) binding to alpha(M)beta(2) directly as part of a recognition interface formed by five noncontiguous segments (Pro(192)-Glu(197), Asn(213)-Glu(220), Leu(225)-Leu(230), Ser(324)-Thr(329), and Glu(344)-Asp(348)) on the apex of the beta(2)I domain.	Proline	182-185	intercellular adhesion molecule 1	Homo sapiens	29-62
15707590-8	2005	The three SH3 domains of CIN85 were essential for this increased susceptibility to apoptosis and its proline-rich regions were also required for maximal effect.	Proline	101-108	SH3 domain containing kinase binding protein 1	Homo sapiens	25-30
15615722-4	2005	On the one hand, it supports intercellular adhesion molecule 1 (ICAM-1) binding to alpha(M)beta(2) directly as part of a recognition interface formed by five noncontiguous segments (Pro(192)-Glu(197), Asn(213)-Glu(220), Leu(225)-Leu(230), Ser(324)-Thr(329), and Glu(344)-Asp(348)) on the apex of the beta(2)I domain.	Proline	182-185	intercellular adhesion molecule 1	Homo sapiens	64-70
15588228-6	2005	In the matrilin-3b gene a unique exon codes for a proline- and serine/threonine-rich domain, possibly having mucin-like properties.	Proline	50-57	matrilin 3b	Danio rerio	7-18
15694258-2	2005	In the present study a synthetic proline-rich-polypeptide of human hypothalamus origin (h-PRP) has been examined for its potency to protect against dopaminergic neuronal damage caused by the parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	Proline	33-40	prion protein	Homo sapiens	90-93
15487984-11	2005	Natural human DPPII showed high efficiency towards synthetic substrates containing proline at the P1 position and lysine at P2.	Proline	83-90	dipeptidyl peptidase 7	Homo sapiens	14-19
15701524-5	2005	In addition, site-directed mutagenesis indicated that the interaction of Pin1 with p54nrb was mediated by three threonine residues located in the proline-rich carboxy-terminal extremity of the protein.	Proline	146-153	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	73-77
15701524-5	2005	In addition, site-directed mutagenesis indicated that the interaction of Pin1 with p54nrb was mediated by three threonine residues located in the proline-rich carboxy-terminal extremity of the protein.	Proline	146-153	non-POU domain containing octamer binding	Homo sapiens	83-89
15662599-1	2005	PRODH maps to 22q11 in the region deleted in the velocardiofacial syndrome/DiGeorge syndrome (VCFS/DGS) and encodes proline oxidase (POX), a mitochondrial inner-membrane enzyme that catalyzes the first step in the proline degradation pathway.	Proline	116-123	proline dehydrogenase 1	Homo sapiens	0-5
15662599-1	2005	PRODH maps to 22q11 in the region deleted in the velocardiofacial syndrome/DiGeorge syndrome (VCFS/DGS) and encodes proline oxidase (POX), a mitochondrial inner-membrane enzyme that catalyzes the first step in the proline degradation pathway.	Proline	116-123	proline dehydrogenase 1	Homo sapiens	133-136
15635649-2	2005	An investigation of a series of single replacement analogues of PrRP-(19-31)-peptide has shown that good functional activity was retained when Phe31 was replaced with His(Bzl), Phe(4Cl), Nle, Trp, Cys(Bzl) or Glu(OBzl); when Val28 or Ile25 was replaced with Phg; when Gly24 was replaced with D-Ala, L-Ala, Pro or Sar; when Ser22 was replaced with Gly and when Ala21 was replaced with Thr or MeAla.	Proline	306-309	prolactin releasing hormone	Homo sapiens	64-68
15725496-7	2005	Its uncommon mode of binding to MMP-8 was mainly ascribed to the presence of the proline residue in P(3).	Proline	81-88	matrix metallopeptidase 8	Homo sapiens	32-37
15718101-0	2005	PRR5 encodes a conserved proline-rich protein predominant in kidney: analysis of genomic organization, expression, and mutation status in breast and colorectal carcinomas.	Proline	25-32	proline rich 5	Homo sapiens	0-4
15731049-4	2005	Remarkably, those proteases that cleave a Pro-Ser peptide bond in the wild-type IgA1 hinge were able to cleave mutant antibodies lacking a Pro-Ser peptide bond in the hinge, and those that cleave a Pro-Thr peptide bond in the wild-type IgA1 hinge were able to cleave mutant antibodies devoid of a Pro-Thr peptide bond in the hinge.	Proline	42-45	immunoglobulin heavy constant alpha 1	Homo sapiens	80-84
15731049-4	2005	Remarkably, those proteases that cleave a Pro-Ser peptide bond in the wild-type IgA1 hinge were able to cleave mutant antibodies lacking a Pro-Ser peptide bond in the hinge, and those that cleave a Pro-Thr peptide bond in the wild-type IgA1 hinge were able to cleave mutant antibodies devoid of a Pro-Thr peptide bond in the hinge.	Proline	42-45	immunoglobulin heavy constant alpha 1	Homo sapiens	236-240
15731049-8	2005	Proline-to-serine substitution at residue 230 in a hinge containing potentially cleavable Pro-Ser and Pro-Thr peptide bonds increased the resistance of the antibody to cleavage by many IgA1 proteases.	Proline	0-3	immunoglobulin heavy constant alpha 1	Homo sapiens	185-189
15708313-1	2005	The antigen-2 or proline rich antigen (Ag2/PRA) from Coccidioides immitis, known to protect mice against experimental Coccidioidomycosis, was expressed in the genetically attenuated cholera vaccine candidate Vibrio cholerae 638 and its thymine auxotrophic derivative 638T.	Proline	17-24	anterior gradient 2	Mus musculus	39-42
15715674-3	2005	We have mutated individual conserved proline residues in the human P2X1 receptor and determined their properties.	Proline	37-44	purinergic receptor P2X 1	Homo sapiens	67-80
15632200-1	2005	The I-band region of the giant muscle protein titin contains a large domain enriched for the amino acids proline, glutamate, valine, and lysine and is denoted the PEVK domain.	Proline	105-112	titin	Homo sapiens	46-51
15743816-6	2005	Mutation of tandem proline-rich (PxxP) motifs in this region disrupts Bem1 binding, suggesting that it serves as a ligand for a Bem1 SH3 domain.	Proline	19-26	phosphatidylinositol-3-phosphate-binding protein BEM1	Saccharomyces cerevisiae S288C	70-74
15743816-6	2005	Mutation of tandem proline-rich (PxxP) motifs in this region disrupts Bem1 binding, suggesting that it serves as a ligand for a Bem1 SH3 domain.	Proline	19-26	phosphatidylinositol-3-phosphate-binding protein BEM1	Saccharomyces cerevisiae S288C	128-132
15525646-2	2005	Pim kinases are highly homologous to one another and share a unique consensus hinge region sequence, ER-PXPX, with its two proline residues separated by a non-conserved residue, but they (Pim kinases) have &lt;30% sequence identity with other kinases.	Proline	123-130	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-3
15709751-8	2005	Conversely, analysis of Cx43 mutants with proline to alanine substitutions in the two proline-rich regions of Cx43 revealed that the P(253)LSP(256) motif is an important determinant of the ability of Cx43 to interact with CIP85.	Proline	42-49	gap junction protein alpha 1	Homo sapiens	24-28
15709751-8	2005	Conversely, analysis of Cx43 mutants with proline to alanine substitutions in the two proline-rich regions of Cx43 revealed that the P(253)LSP(256) motif is an important determinant of the ability of Cx43 to interact with CIP85.	Proline	42-49	gap junction protein alpha 1	Homo sapiens	110-114
15709751-8	2005	Conversely, analysis of Cx43 mutants with proline to alanine substitutions in the two proline-rich regions of Cx43 revealed that the P(253)LSP(256) motif is an important determinant of the ability of Cx43 to interact with CIP85.	Proline	42-49	gap junction protein alpha 1	Homo sapiens	110-114
15709751-8	2005	Conversely, analysis of Cx43 mutants with proline to alanine substitutions in the two proline-rich regions of Cx43 revealed that the P(253)LSP(256) motif is an important determinant of the ability of Cx43 to interact with CIP85.	Proline	86-93	gap junction protein alpha 1	Homo sapiens	24-28
15709751-8	2005	Conversely, analysis of Cx43 mutants with proline to alanine substitutions in the two proline-rich regions of Cx43 revealed that the P(253)LSP(256) motif is an important determinant of the ability of Cx43 to interact with CIP85.	Proline	86-93	gap junction protein alpha 1	Homo sapiens	110-114
15709751-8	2005	Conversely, analysis of Cx43 mutants with proline to alanine substitutions in the two proline-rich regions of Cx43 revealed that the P(253)LSP(256) motif is an important determinant of the ability of Cx43 to interact with CIP85.	Proline	86-93	gap junction protein alpha 1	Homo sapiens	110-114
15525646-2	2005	Pim kinases are highly homologous to one another and share a unique consensus hinge region sequence, ER-PXPX, with its two proline residues separated by a non-conserved residue, but they (Pim kinases) have &lt;30% sequence identity with other kinases.	Proline	123-130	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	188-191
15588252-3	2005	Here, we show that the proline-rich linker region of Smad3 contains a transcriptional activation domain.	Proline	23-30	SMAD family member 3	Homo sapiens	53-58
15671060-7	2005	The effect of actin polymerization on the interaction between cortactin and the dynamin proline-rich domain (PRD) was further evaluated under a condition for actin polymerization in vitro.	Proline	88-95	cortactin	Homo sapiens	62-71
15701922-3	2005	One of the most recently identified is migfilin, a widely expressed protein consisting of an N-terminal filamin-binding domain, a central proline-rich domain and three C-terminal LIM domains.	Proline	138-145	filamin binding LIM protein 1	Homo sapiens	39-47
15697300-3	2005	We have synthesized an unnatural protein with the sequence thioredoxin-Pro(39)Glu(10) for modification of the forces between alumina particles.	Proline	71-74	thioredoxin	Homo sapiens	59-70
15710406-5	2005	We propose that Spred1 will bind peptides that are less proline-rich than other EVH1 domains, with conformational changes indicating an induced fit.	Proline	56-63	sprouty related, EVH1 domain containing 1	Xenopus tropicalis	16-22
15710380-4	2005	Changing them from Ser, Glu and Ser to Phe, Ala and Pro, respectively, transformed the nonapeptide into an excellent substrate for PKBalpha and RSK1.	Proline	52-55	AKT serine/threonine kinase 1	Homo sapiens	131-139
15569682-9	2005	Overexpression of Gm-CaM4 in Arabidopsis up-regulates the transcription rate of AtMYB2-regulated genes, including the proline-synthesizing enzyme P5CS1 (Delta1-pyrroline-5-carboxylate synthetase-1), which confers salt tolerance by facilitating proline accumulation.	Proline	118-125	calmodulin 4	Arabidopsis thaliana	21-25
15710380-4	2005	Changing them from Ser, Glu and Ser to Phe, Ala and Pro, respectively, transformed the nonapeptide into an excellent substrate for PKBalpha and RSK1.	Proline	52-55	ribosomal protein S6 kinase A1	Homo sapiens	144-148
15557335-4	2005	A proline-rich region in the C terminus of Alix bound the Src SH3 domain, but this interaction was dependent on the release of the Src SH2 domain from its Src internal ligand either by interaction with Alix Tyr319 or by mutation of Src Tyr527.	Proline	2-9	programmed cell death 6 interacting protein	Homo sapiens	43-47
15557335-4	2005	A proline-rich region in the C terminus of Alix bound the Src SH3 domain, but this interaction was dependent on the release of the Src SH2 domain from its Src internal ligand either by interaction with Alix Tyr319 or by mutation of Src Tyr527.	Proline	2-9	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	58-61
15537638-1	2005	Two phenotypic missense mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) channel pore (L346P and R347P in transmembrane (TM) segment 6) involve gain of a proline residue, but only L346P represents a significant loss of segment hydropathy.	Proline	181-188	CF transmembrane conductance regulator	Homo sapiens	41-92
15537638-1	2005	Two phenotypic missense mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) channel pore (L346P and R347P in transmembrane (TM) segment 6) involve gain of a proline residue, but only L346P represents a significant loss of segment hydropathy.	Proline	181-188	CF transmembrane conductance regulator	Homo sapiens	94-98
15629447-1	2005	Proteomic analyses have revealed a novel synaptic proline-rich membrane protein: PRR7 (proline rich 7), in the postsynaptic density (PSD) fraction of rat forebrain.	Proline	50-57	proline rich 7 (synaptic)	Rattus norvegicus	81-85
15629447-1	2005	Proteomic analyses have revealed a novel synaptic proline-rich membrane protein: PRR7 (proline rich 7), in the postsynaptic density (PSD) fraction of rat forebrain.	Proline	50-57	proline rich 7 (synaptic)	Rattus norvegicus	87-101
15629447-2	2005	PRR7 is 269 amino acid residues long, and displays a unique architecture, composed of a very short N-terminal extracellular region, a single membrane spanning domain, and a cytoplasmic domain possessing a proline-rich sequence and a C-terminal type-1 PDZ binding motif.	Proline	205-212	proline rich 7 (synaptic)	Rattus norvegicus	0-4
15569682-9	2005	Overexpression of Gm-CaM4 in Arabidopsis up-regulates the transcription rate of AtMYB2-regulated genes, including the proline-synthesizing enzyme P5CS1 (Delta1-pyrroline-5-carboxylate synthetase-1), which confers salt tolerance by facilitating proline accumulation.	Proline	118-125	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	146-151
15569682-9	2005	Overexpression of Gm-CaM4 in Arabidopsis up-regulates the transcription rate of AtMYB2-regulated genes, including the proline-synthesizing enzyme P5CS1 (Delta1-pyrroline-5-carboxylate synthetase-1), which confers salt tolerance by facilitating proline accumulation.	Proline	118-125	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	159-196
15569682-9	2005	Overexpression of Gm-CaM4 in Arabidopsis up-regulates the transcription rate of AtMYB2-regulated genes, including the proline-synthesizing enzyme P5CS1 (Delta1-pyrroline-5-carboxylate synthetase-1), which confers salt tolerance by facilitating proline accumulation.	Proline	244-251	calmodulin 4	Arabidopsis thaliana	21-25
15569682-9	2005	Overexpression of Gm-CaM4 in Arabidopsis up-regulates the transcription rate of AtMYB2-regulated genes, including the proline-synthesizing enzyme P5CS1 (Delta1-pyrroline-5-carboxylate synthetase-1), which confers salt tolerance by facilitating proline accumulation.	Proline	244-251	myb domain protein 2	Arabidopsis thaliana	80-86
15681836-8	2005	p75NTR-transfected cells underwent apoptosis in the presence of pro-NGF while control wild-type cells did not.	Proline	64-67	nerve growth factor receptor	Homo sapiens	0-6
15689539-6	2005	We further demonstrated that the proline-rich region present in C termini of CaV1.3a subunit binds to Shank Src homology 3 domain.	Proline	33-40	caveolin 1	Rattus norvegicus	77-81
15840943-1	2005	The microtubule-binding domain of MAP4, a ubiquitous microtubule-associated protein, contains a region rich in proline and basic residues (proline-rich region).	Proline	111-118	microtubule-associated protein 4	Bos taurus	34-38
15727652-5	2005	Sequence analysis of CTSC in the proband revealed a homozygous mutation at codon 196 (587T-->C) within exon 4 that altered the conserved leucine to proline (Leu196Pro), whereas the patient"s mother was heterozygous for that mutation.	Proline	148-155	cathepsin C	Homo sapiens	21-25
15605275-5	2005	However, the amino acid substitution was proline for arginine (R162P) in the 1A rod domain, the highly conserved helix initiation motif of keratin 9.	Proline	41-48	keratin 9	Homo sapiens	139-148
15840943-1	2005	The microtubule-binding domain of MAP4, a ubiquitous microtubule-associated protein, contains a region rich in proline and basic residues (proline-rich region).	Proline	139-146	microtubule-associated protein 4	Bos taurus	34-38
15840943-8	2005	The fragment induced microtubule assembly and bound to preformed microtubules, but the activities were slightly lower than those of the conventional MAP4 fragment, which carries the full-length proline-rich region.	Proline	194-201	microtubule-associated protein 4	Bos taurus	149-153
15486046-12	2005	In summary, 1) SHIP-WT and SHIPDeltaIP expression inhibit insulin and PDGF stimulated Ras, MAPK kinase, and MAPK activities; 2) SHIP associates with tyrosine phosphorylated Shc, and the proline-rich sequences in SHIP associate with Grb2 and titrate out SOS to form Shc*Grb2*SHIP complexes; and 3) dissociation of SOS from the Shc*Grb2 complex inhibits Ras GTP loading, leading to decreased signaling through the MAPK pathway.	Proline	186-193	insulin	Homo sapiens	58-65
15650559-6	2005	Interaction of apoA-I with ABCA1 prevents phosphorylation of a sequence rich in proline, glutamic acid, serine and threonine in a cytoplasmic domain of ABCA1, resulting in less degradation by calpain proteolysis and increased surface expression of ABCA1.	Proline	80-87	apolipoprotein A1	Homo sapiens	15-21
15650559-6	2005	Interaction of apoA-I with ABCA1 prevents phosphorylation of a sequence rich in proline, glutamic acid, serine and threonine in a cytoplasmic domain of ABCA1, resulting in less degradation by calpain proteolysis and increased surface expression of ABCA1.	Proline	80-87	ATP binding cassette subfamily A member 1	Homo sapiens	27-32
15650559-6	2005	Interaction of apoA-I with ABCA1 prevents phosphorylation of a sequence rich in proline, glutamic acid, serine and threonine in a cytoplasmic domain of ABCA1, resulting in less degradation by calpain proteolysis and increased surface expression of ABCA1.	Proline	80-87	ATP binding cassette subfamily A member 1	Homo sapiens	152-157
15650559-6	2005	Interaction of apoA-I with ABCA1 prevents phosphorylation of a sequence rich in proline, glutamic acid, serine and threonine in a cytoplasmic domain of ABCA1, resulting in less degradation by calpain proteolysis and increased surface expression of ABCA1.	Proline	80-87	ATP binding cassette subfamily A member 1	Homo sapiens	152-157
15687218-0	2005	Mutational alterations of the key cis proline residue that cause accumulation of enzymatic reaction intermediates of DsbA, a member of the thioredoxin superfamily.	Proline	38-45	thioredoxin	Homo sapiens	139-150
16040349-2	2005	The open reading frame corresponded to 389 amino acids: It contained the phagocyte oxidase homology domain, two Src homology 3 domains and a proline rich region, all of which are conserved in mammalian p47phox sequences.	Proline	141-148	neutrophil cytosolic factor 1	Homo sapiens	202-209
15486046-12	2005	In summary, 1) SHIP-WT and SHIPDeltaIP expression inhibit insulin and PDGF stimulated Ras, MAPK kinase, and MAPK activities; 2) SHIP associates with tyrosine phosphorylated Shc, and the proline-rich sequences in SHIP associate with Grb2 and titrate out SOS to form Shc*Grb2*SHIP complexes; and 3) dissociation of SOS from the Shc*Grb2 complex inhibits Ras GTP loading, leading to decreased signaling through the MAPK pathway.	Proline	186-193	inositol polyphosphate-5-phosphatase D	Homo sapiens	15-19
15486046-12	2005	In summary, 1) SHIP-WT and SHIPDeltaIP expression inhibit insulin and PDGF stimulated Ras, MAPK kinase, and MAPK activities; 2) SHIP associates with tyrosine phosphorylated Shc, and the proline-rich sequences in SHIP associate with Grb2 and titrate out SOS to form Shc*Grb2*SHIP complexes; and 3) dissociation of SOS from the Shc*Grb2 complex inhibits Ras GTP loading, leading to decreased signaling through the MAPK pathway.	Proline	186-193	SHC adaptor protein 1	Homo sapiens	173-176
15486046-12	2005	In summary, 1) SHIP-WT and SHIPDeltaIP expression inhibit insulin and PDGF stimulated Ras, MAPK kinase, and MAPK activities; 2) SHIP associates with tyrosine phosphorylated Shc, and the proline-rich sequences in SHIP associate with Grb2 and titrate out SOS to form Shc*Grb2*SHIP complexes; and 3) dissociation of SOS from the Shc*Grb2 complex inhibits Ras GTP loading, leading to decreased signaling through the MAPK pathway.	Proline	186-193	inositol polyphosphate-5-phosphatase D	Homo sapiens	27-31
15486046-12	2005	In summary, 1) SHIP-WT and SHIPDeltaIP expression inhibit insulin and PDGF stimulated Ras, MAPK kinase, and MAPK activities; 2) SHIP associates with tyrosine phosphorylated Shc, and the proline-rich sequences in SHIP associate with Grb2 and titrate out SOS to form Shc*Grb2*SHIP complexes; and 3) dissociation of SOS from the Shc*Grb2 complex inhibits Ras GTP loading, leading to decreased signaling through the MAPK pathway.	Proline	186-193	growth factor receptor bound protein 2	Homo sapiens	232-236
15486046-12	2005	In summary, 1) SHIP-WT and SHIPDeltaIP expression inhibit insulin and PDGF stimulated Ras, MAPK kinase, and MAPK activities; 2) SHIP associates with tyrosine phosphorylated Shc, and the proline-rich sequences in SHIP associate with Grb2 and titrate out SOS to form Shc*Grb2*SHIP complexes; and 3) dissociation of SOS from the Shc*Grb2 complex inhibits Ras GTP loading, leading to decreased signaling through the MAPK pathway.	Proline	186-193	SHC adaptor protein 1	Homo sapiens	265-268
15486046-12	2005	In summary, 1) SHIP-WT and SHIPDeltaIP expression inhibit insulin and PDGF stimulated Ras, MAPK kinase, and MAPK activities; 2) SHIP associates with tyrosine phosphorylated Shc, and the proline-rich sequences in SHIP associate with Grb2 and titrate out SOS to form Shc*Grb2*SHIP complexes; and 3) dissociation of SOS from the Shc*Grb2 complex inhibits Ras GTP loading, leading to decreased signaling through the MAPK pathway.	Proline	186-193	growth factor receptor bound protein 2	Homo sapiens	269-273
15486046-12	2005	In summary, 1) SHIP-WT and SHIPDeltaIP expression inhibit insulin and PDGF stimulated Ras, MAPK kinase, and MAPK activities; 2) SHIP associates with tyrosine phosphorylated Shc, and the proline-rich sequences in SHIP associate with Grb2 and titrate out SOS to form Shc*Grb2*SHIP complexes; and 3) dissociation of SOS from the Shc*Grb2 complex inhibits Ras GTP loading, leading to decreased signaling through the MAPK pathway.	Proline	186-193	inositol polyphosphate-5-phosphatase D	Homo sapiens	27-31
15486046-12	2005	In summary, 1) SHIP-WT and SHIPDeltaIP expression inhibit insulin and PDGF stimulated Ras, MAPK kinase, and MAPK activities; 2) SHIP associates with tyrosine phosphorylated Shc, and the proline-rich sequences in SHIP associate with Grb2 and titrate out SOS to form Shc*Grb2*SHIP complexes; and 3) dissociation of SOS from the Shc*Grb2 complex inhibits Ras GTP loading, leading to decreased signaling through the MAPK pathway.	Proline	186-193	SHC adaptor protein 1	Homo sapiens	265-268
15486046-12	2005	In summary, 1) SHIP-WT and SHIPDeltaIP expression inhibit insulin and PDGF stimulated Ras, MAPK kinase, and MAPK activities; 2) SHIP associates with tyrosine phosphorylated Shc, and the proline-rich sequences in SHIP associate with Grb2 and titrate out SOS to form Shc*Grb2*SHIP complexes; and 3) dissociation of SOS from the Shc*Grb2 complex inhibits Ras GTP loading, leading to decreased signaling through the MAPK pathway.	Proline	186-193	growth factor receptor bound protein 2	Homo sapiens	269-273
15684386-6	2005	Similar results were obtained with IRP2(Delta)(73), a mutant lacking a conserved, IRP2-specific proline- and cysteine-rich domain.	Proline	96-103	iron responsive element binding protein 2	Homo sapiens	35-39
15684386-6	2005	Similar results were obtained with IRP2(Delta)(73), a mutant lacking a conserved, IRP2-specific proline- and cysteine-rich domain.	Proline	96-103	iron responsive element binding protein 2	Homo sapiens	82-86
15635447-2	2005	IRSp53 comprises a central SH3 domain, which binds to proline-rich regions of a wide range of actin regulators, and a conserved N-terminal IRSp53/MIM homology domain (IMD) that harbours F-actin-bundling activity.	Proline	54-61	BAR/IMD domain containing adaptor protein 2	Homo sapiens	0-6
15657436-8	2005	At the biochemical level, HOXA9 mediates these effects by competing with factors that repress eIF4E function, in particular the proline-rich homeodomain PRH/Hex.	Proline	128-135	homeobox A9	Homo sapiens	26-31
15657436-8	2005	At the biochemical level, HOXA9 mediates these effects by competing with factors that repress eIF4E function, in particular the proline-rich homeodomain PRH/Hex.	Proline	128-135	eukaryotic translation initiation factor 4E	Homo sapiens	94-99
15657436-8	2005	At the biochemical level, HOXA9 mediates these effects by competing with factors that repress eIF4E function, in particular the proline-rich homeodomain PRH/Hex.	Proline	128-135	hematopoietically expressed homeobox	Homo sapiens	153-156
15657436-8	2005	At the biochemical level, HOXA9 mediates these effects by competing with factors that repress eIF4E function, in particular the proline-rich homeodomain PRH/Hex.	Proline	128-135	hematopoietically expressed homeobox	Homo sapiens	157-160
15361070-1	2005	APP (aminopeptidase P) has the unique ability to cleave the N-terminal amino acid residue from peptides exhibiting a proline at P(1)".	Proline	117-124	amyloid beta precursor protein	Homo sapiens	5-21
15673667-8	2005	In addition, the density and size of spines are decreased by a dominant-negative IRSp53 with a point mutation in the Src homology 3 (SH3) domain and a dominant-negative proline-rich region of WAVE2 (Wiskott-Aldrich syndrome protein family Verprolin-homologous protein), a downstream effector of IRSp53 that binds to the SH3 domain of IRSp53.	Proline	169-176	BAR/IMD domain containing adaptor protein 2	Homo sapiens	81-87
15673667-8	2005	In addition, the density and size of spines are decreased by a dominant-negative IRSp53 with a point mutation in the Src homology 3 (SH3) domain and a dominant-negative proline-rich region of WAVE2 (Wiskott-Aldrich syndrome protein family Verprolin-homologous protein), a downstream effector of IRSp53 that binds to the SH3 domain of IRSp53.	Proline	169-176	WASP family member 2	Homo sapiens	192-197
15596140-4	2005	The SH3 domain interacts with the proline rich domain of mDab2 which had been identified to possess a transcriptional activation function.	Proline	34-41	disabled 2, mitogen-responsive phosphoprotein	Mus musculus	57-62
15664191-4	2005	Five of the identified sites are proline-directed targets of activated ERK, and phosphorylation of all six sites requires MEK signaling, indicating a negative feedback mechanism.	Proline	33-40	mitogen-activated protein kinase 1	Homo sapiens	71-74
15664191-4	2005	Five of the identified sites are proline-directed targets of activated ERK, and phosphorylation of all six sites requires MEK signaling, indicating a negative feedback mechanism.	Proline	33-40	mitogen-activated protein kinase kinase 7	Homo sapiens	122-125
15528200-8	2005	All the peptides efficiently hydroxylated by At-P4H-2 had at least 3 consecutive prolines, suggesting that these may represent a minimum requirement for efficient hydroxylation by this isoenzyme.	Proline	81-89	P4H 	Arabidopsis thaliana	48-51
15642358-2	2005	Proline-rich proteins like vinculin and zyxin are well established interaction partners, which mediate Ena/VASP-recruitment via their EVH1-domains to focal adhesions and stress fibres.	Proline	0-7	Vinculin	Caenorhabditis elegans	27-35
15642358-4	2005	Here, we report the identification of a novel protein with high similarity to the C. elegans MIG-10 protein, which we termed PREL1 (Proline Rich EVH1 Ligand).	Proline	132-139	Abnormal cell migration protein 10	Caenorhabditis elegans	93-99
15528200-9	2005	N-terminal sequencing of an extensin-like peptide SPPPVYKSPPPPVKHYSPPPV indicated that At-P4H-2 preferentially hydroxylated the 3rd proline in the C-terminal PPP triplet.	Proline	132-139	P4H 	Arabidopsis thaliana	87-95
15516976-3	2005	Sequence analysis revealed a polymorphism of Mtf-1 that alters the corresponding amino acid at position 424 in the proline-rich domain from a serine in susceptibility strains to proline in resistant strains.	Proline	115-122	metal response element binding transcription factor 1	Mus musculus	45-50
15649318-4	2005	LPP has three LIM domains (zinc-finger protein interaction domains) at its carboxy-terminus, which are preceded by a proline-rich pre-LIM region containing a number of protein interaction domains.	Proline	117-124	LIM domain containing preferred translocation partner in lipoma	Homo sapiens	0-3
15633234-0	2005	Homozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chinese population.	Proline	17-20	tumor protein p53	Homo sapiens	24-27
15633234-10	2005	CONCLUSION: Homozygosity for Pro of p53 Arg72Pro is potentially one of the genetic risk factors for HCC in Chinese population.	Proline	29-32	tumor protein p53	Homo sapiens	36-39
15516976-3	2005	Sequence analysis revealed a polymorphism of Mtf-1 that alters the corresponding amino acid at position 424 in the proline-rich domain from a serine in susceptibility strains to proline in resistant strains.	Proline	178-185	metal response element binding transcription factor 1	Mus musculus	45-50
15516976-4	2005	The transcriptional activity of Mtf-1 encoding serine and proline was compared by transfecting the DNA to Mtf-1-null cells, and the change to proline conferred a higher metal responsiveness in transfections.	Proline	142-149	metal response element binding transcription factor 1	Mus musculus	32-37
15516976-5	2005	Furthermore, the resistant congenic strains possessing the Mtf-1 allele of proline type exhibited higher radiation inducibility of target genes than susceptible background strains having the Mtf-1 allele of serine type.	Proline	75-82	metal response element binding transcription factor 1	Mus musculus	59-64
15628844-2	2005	DtxR contains an N-terminal metal- and DNA-binding domain that is connected by a proline-rich flexible peptide segment (Pr) to a C-terminal src homology 3 (SH3)-like domain.	Proline	81-88	MarR family transcriptional regulator	Corynebacterium diphtheriae	0-4
15516976-6	2005	Since products of the targets such as metallothionein are able to suppress cellular stresses generated by irradiation, these results suggest that highly inducible strains having Mtf-1 of proline type are refractory to radiation effects and hence are resistant to lymphoma development.	Proline	187-194	metal response element binding transcription factor 1	Mus musculus	178-183
15628844-10	2005	Together, the structural and biophysical studies suggest that the proline-rich peptide segment of DtxR functions as a switch that modulates the activation of repressor activity.	Proline	66-73	MarR family transcriptional regulator	Corynebacterium diphtheriae	98-102
15649325-10	2005	Mutation of the proline-rich motifs at the C-terminal of PTTG1 abolished its oncogenic properties.	Proline	16-23	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	57-62
16508092-1	2005	Bri3 is a recently identified proline-rich transmembrane polypeptide up-regulated during TNF-mediated inflammation and immunity.	Proline	30-37	brain protein I3	Homo sapiens	0-4
16508092-1	2005	Bri3 is a recently identified proline-rich transmembrane polypeptide up-regulated during TNF-mediated inflammation and immunity.	Proline	30-37	tumor necrosis factor	Homo sapiens	89-92
15647492-3	2005	The interaction involves a two-point attachment of the C-terminal region of Densin-180 with the Src homology 3 domain and the N-terminal part of the proline-rich region of shank proteins.	Proline	149-156	leucine rich repeat containing 7	Homo sapiens	76-86
15647492-3	2005	The interaction involves a two-point attachment of the C-terminal region of Densin-180 with the Src homology 3 domain and the N-terminal part of the proline-rich region of shank proteins.	Proline	149-156	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	172-177
15615648-7	2005	Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and probably catalyzes cis/trans isomerization of pSer/Thr-Pro motif(s), thereby inducing conformational changes in tau.	Proline	60-63	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
15615649-2	2005	Mediated by the proline-rich region of tau and the SH3 domain of fyn or src, this interaction has the potential to confer novel cellular activities for tau in the growth cone and in the membrane.	Proline	16-23	microtubule associated protein tau	Homo sapiens	39-42
15615649-2	2005	Mediated by the proline-rich region of tau and the SH3 domain of fyn or src, this interaction has the potential to confer novel cellular activities for tau in the growth cone and in the membrane.	Proline	16-23	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	65-68
15615649-2	2005	Mediated by the proline-rich region of tau and the SH3 domain of fyn or src, this interaction has the potential to confer novel cellular activities for tau in the growth cone and in the membrane.	Proline	16-23	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	72-75
15615649-2	2005	Mediated by the proline-rich region of tau and the SH3 domain of fyn or src, this interaction has the potential to confer novel cellular activities for tau in the growth cone and in the membrane.	Proline	16-23	microtubule associated protein tau	Homo sapiens	152-155
15609295-6	2005	DNA sequencing analysis showed the patient to be a compound heterozygote for two mutations in the GPIX gene, a novel nine-nucleotide deletion starting at position 1952 of the gene that changes asparagine 86 for alanine and eliminates amino acids 87, 88, and 89 (arginine, threonine, and proline) and a previously reported point mutation that changes the codon asparagine (AAC) for serine (AGC) at residue 45.	Proline	287-294	glycoprotein IX platelet	Homo sapiens	98-102
15649325-15	2005	Mutation of C-terminal proline-rich motifs abrogates the oncogenic function of PTTG1.	Proline	23-30	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	79-84
15701055-8	2005	The 14-3-3-binding motif Lys-Lys-Glu-Ser-His-Pro (371-376) was detected in the HvNHX2 amino acid sequence, which is suggestive of possible involvement of the 14-3-3 proteins in the regulation of HvNHX2 function.	Proline	45-48	sodium/proton exchanger	Hordeum vulgare	79-85
15701055-8	2005	The 14-3-3-binding motif Lys-Lys-Glu-Ser-His-Pro (371-376) was detected in the HvNHX2 amino acid sequence, which is suggestive of possible involvement of the 14-3-3 proteins in the regulation of HvNHX2 function.	Proline	45-48	sodium/proton exchanger	Hordeum vulgare	195-201
15617811-1	2005	The effect of three osmolytes, trimethylamine N-oxide (TMAO), betaine and proline, on the interaction of muscle glycogen phosphorylase b with allosteric inhibitor FAD has been examined.	Proline	74-81	glycogen phosphorylase B	Homo sapiens	112-136
16122882-1	2005	BACKGROUND: The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to human papillomavirus (HPV) infection and thus altering cancer risk.	Proline	44-47	tumor protein p53	Homo sapiens	78-81
15644866-4	2005	At extracellular pH 5.5 (in Na(+)-free conditions) proline uptake was saturable (Km 172+/-41 muM), demonstrating that rPAT2 is, relative to PAT1, a high-affinity transporter.PAT2 preferred substrates are L-alpha-amino acids with small aliphatic side chains (e.g. the methyl group in alanine) and 4- or 5-membered heterocyclic amino and imino acids such as 2-azetidine-carboxylate, proline and cycloserine, where both D- and L-enantiomers are transported.	Proline	51-58	solute carrier family 36 member 2	Rattus norvegicus	118-123
15644866-4	2005	At extracellular pH 5.5 (in Na(+)-free conditions) proline uptake was saturable (Km 172+/-41 muM), demonstrating that rPAT2 is, relative to PAT1, a high-affinity transporter.PAT2 preferred substrates are L-alpha-amino acids with small aliphatic side chains (e.g. the methyl group in alanine) and 4- or 5-membered heterocyclic amino and imino acids such as 2-azetidine-carboxylate, proline and cycloserine, where both D- and L-enantiomers are transported.	Proline	51-58	solute carrier family 36 member 2	Rattus norvegicus	119-123
15644866-4	2005	At extracellular pH 5.5 (in Na(+)-free conditions) proline uptake was saturable (Km 172+/-41 muM), demonstrating that rPAT2 is, relative to PAT1, a high-affinity transporter.PAT2 preferred substrates are L-alpha-amino acids with small aliphatic side chains (e.g. the methyl group in alanine) and 4- or 5-membered heterocyclic amino and imino acids such as 2-azetidine-carboxylate, proline and cycloserine, where both D- and L-enantiomers are transported.	Proline	381-388	solute carrier family 36 member 2	Rattus norvegicus	118-123
15644866-4	2005	At extracellular pH 5.5 (in Na(+)-free conditions) proline uptake was saturable (Km 172+/-41 muM), demonstrating that rPAT2 is, relative to PAT1, a high-affinity transporter.PAT2 preferred substrates are L-alpha-amino acids with small aliphatic side chains (e.g. the methyl group in alanine) and 4- or 5-membered heterocyclic amino and imino acids such as 2-azetidine-carboxylate, proline and cycloserine, where both D- and L-enantiomers are transported.	Proline	381-388	solute carrier family 36 member 2	Rattus norvegicus	119-123
16122882-1	2005	BACKGROUND: The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to human papillomavirus (HPV) infection and thus altering cancer risk.	Proline	51-54	tumor protein p53	Homo sapiens	78-81
16122882-1	2005	BACKGROUND: The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to human papillomavirus (HPV) infection and thus altering cancer risk.	Proline	51-54	tumor protein p53	Homo sapiens	78-81
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Proline	170-177	aldehyde dehydrogenase 18 family member A1	Homo sapiens	18-51
15663510-8	2005	DNA sequencing in all the affected individuals disclosed a heterozygous G--&gt;C substitution at nucleotide 173 of the fumarate hydratase gene, that converts an arginine residue (CGA) to proline (CCA).	Proline	187-194	fumarate hydratase	Homo sapiens	119-137
15663510-8	2005	DNA sequencing in all the affected individuals disclosed a heterozygous G--&gt;C substitution at nucleotide 173 of the fumarate hydratase gene, that converts an arginine residue (CGA) to proline (CCA).	Proline	187-194	chromogranin A	Homo sapiens	179-182
15619005-3	2005	Thus, Sam68 has various proline-rich sequences to interact with SH3 domain-containing proteins.	Proline	24-31	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	6-11
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Proline	170-177	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
15664727-7	2005	Despite having a 2.5-fold increased cancer incidence, the p53 codon 72 Pro/Pro individuals exhibited a significant 41% enhanced survival compared to codon 72 Arg/Pro and Arg/Arg individuals.	Proline	71-74	transformation related protein 53, pseudogene	Mus musculus	58-61
15732191-9	2005	Replacement of arginine (Arg) by proline (Pro) at position 72 of human p53 decreases its apoptotic potential [Dumont et al., 2003.	Proline	33-40	tumor protein p53	Homo sapiens	71-74
15768558-0	2005	Two new hemoglobin variants: Hb Brem-sur-Mer [beta9(A6)Ser-->Tyr] and Hb Passy [alpha81(F2)Ser-->Pro (alpha2)].	Proline	97-100	glycoprotein hormone subunit alpha 2	Homo sapiens	102-108
15732191-9	2005	Replacement of arginine (Arg) by proline (Pro) at position 72 of human p53 decreases its apoptotic potential [Dumont et al., 2003.	Proline	42-45	tumor protein p53	Homo sapiens	71-74
15768558-1	2005	Two new hemoglobin (Hb) variants: Hb Brem-sur-Mer [codon 9 (TCT-->TAT); beta9(A6)Ser-->Tyr] on the first exon of the beta-globin gene and Hb Passy [codon 81 (TCC-->CCC); alpha81(F2)Ser-->Pro (alpha2)] on the second exon of the alpha2-globin gene, are described.	Proline	187-190	immunoglobulin kappa variable 1D-22 (pseudogene)	Homo sapiens	72-77
15768558-1	2005	Two new hemoglobin (Hb) variants: Hb Brem-sur-Mer [codon 9 (TCT-->TAT); beta9(A6)Ser-->Tyr] on the first exon of the beta-globin gene and Hb Passy [codon 81 (TCC-->CCC); alpha81(F2)Ser-->Pro (alpha2)] on the second exon of the alpha2-globin gene, are described.	Proline	187-190	MER proto-oncogene, tyrosine kinase	Homo sapiens	46-49
15381149-3	2005	Prk1p also contains a proline-rich motif near its C-terminus that is required for the proper subcellular localization of the protein.	Proline	22-29	serine/threonine protein kinase PRK1	Saccharomyces cerevisiae S288C	0-5
15558059-0	2005	Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation.	Proline	6-13	signal transducer and activator of transcription 3	Mus musculus	70-75
16281172-1	2005	In a previous study, we showed that the proline-rich divergent homeobox gene Hex/Prh is expressed in dorsal skin of the chick embryo before and during feather bud development and that the pattern of Hex mRNA expression in the epidermis is similar to that of Wnt7a mRNA.	Proline	40-47	Wnt family member 7A	Gallus gallus	258-263
16114264-2	2005	A short proline rich sequence in the N-terminal domain of ColQ or PRiMA associates four C-terminal extension of AChE or BChE.	Proline	8-15	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	58-62
16114264-2	2005	A short proline rich sequence in the N-terminal domain of ColQ or PRiMA associates four C-terminal extension of AChE or BChE.	Proline	8-15	proline rich membrane anchor 1	Homo sapiens	66-71
16114264-2	2005	A short proline rich sequence in the N-terminal domain of ColQ or PRiMA associates four C-terminal extension of AChE or BChE.	Proline	8-15	acetylcholinesterase (Cartwright blood group)	Homo sapiens	112-116
16114264-2	2005	A short proline rich sequence in the N-terminal domain of ColQ or PRiMA associates four C-terminal extension of AChE or BChE.	Proline	8-15	butyrylcholinesterase	Homo sapiens	120-124
15951849-11	2005	PIKE-A contains the same domains present in PIKE-L but lacks N-terminal proline-rich domain (PRD), which binds PI 3-kinase and PLC-gamma1.	Proline	72-79	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	Homo sapiens	0-4
15976924-1	2005	The Nef protein of human immunodeficiency virus type 1 (HIV-1) is known to directly bind to the SH3 domain of human lymphocyte specific kinase (Lck) via a proline-rich region located in the amino terminal part of Nef.	Proline	155-162	Nef	Human immunodeficiency virus 1	4-7
15976924-1	2005	The Nef protein of human immunodeficiency virus type 1 (HIV-1) is known to directly bind to the SH3 domain of human lymphocyte specific kinase (Lck) via a proline-rich region located in the amino terminal part of Nef.	Proline	155-162	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	116-142
15976924-1	2005	The Nef protein of human immunodeficiency virus type 1 (HIV-1) is known to directly bind to the SH3 domain of human lymphocyte specific kinase (Lck) via a proline-rich region located in the amino terminal part of Nef.	Proline	155-162	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	144-147
15976924-1	2005	The Nef protein of human immunodeficiency virus type 1 (HIV-1) is known to directly bind to the SH3 domain of human lymphocyte specific kinase (Lck) via a proline-rich region located in the amino terminal part of Nef.	Proline	155-162	S100 calcium binding protein B	Homo sapiens	213-216
16696315-8	2005	Moreover, plasma insulin concentrations at 60 min was lower than those without A variant (P = 0.0275), and both hypertensive Ala/Pro in HOMA-beta (P = 0.0455) and AUC for insulin (P = 0.0473) were higher, and HOMA-IR was lower (P = 0.0375) as compared with hypertensive Pro/Pro subjects.	Proline	129-132	insulin	Homo sapiens	171-178
15558059-0	2005	Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation.	Proline	6-13	interleukin 6	Mus musculus	65-69
15804176-0	2005	Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs.	Proline	61-68	peptidase D	Homo sapiens	0-9
15893113-2	2005	Pin1 controls the ready (low energy change) equilibrium between the cis and trans distinctive folding configurations differentially at a proline residue: this amino acid residue in proteins is unique in bending sharply its peptide chain (to 90 degrees change): in the cis rather than trans orientation with respect to the peptide bond to residue X "upstream" linked as XCONHR.	Proline	137-144	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
15804176-2	2005	The analyses indicated that prolidase might be a desirable enzyme target based on its differential expression in melanoma cancer cell lines and its high substrate specificity for dipeptides containing proline at the carboxy terminus.	Proline	201-208	peptidase D	Homo sapiens	28-37
16391387-6	2005	Deletion-mapping studies indicate that binding occurs via a proline-rich domain in NAKAP with a WW domain of HypA.	Proline	60-67	A-kinase anchoring protein 8 like	Homo sapiens	83-88
16391387-6	2005	Deletion-mapping studies indicate that binding occurs via a proline-rich domain in NAKAP with a WW domain of HypA.	Proline	60-67	pre-mRNA processing factor 40 homolog A	Homo sapiens	109-113
15844595-1	2005	OBJECTIVE: To investigate the codon-72 polymorphism of the tumor suppressor gene p53, codon-72 encodes arginine (Arg) or proline (Pro) for a genetic predisposition,to keloid or hypertrophic scar.	Proline	121-128	tumor protein p53	Homo sapiens	81-84
15901131-5	2005	Intermediate expression of p53 was noted in cells with missense mutations or polymorphism to proline at codon 72 in exons 4-5, whereas there was slight or no visible expression in wild type cells and in cells with nonsense and frameshift mutations.	Proline	93-100	tumor protein p53	Homo sapiens	27-30
15995598-6	2005	A proline-rich polypeptide (PRP) demonstrated a variety of immunotropic functions, including the promotion of T-cell maturation and inhibition of autoimmune disorders.	Proline	2-9	complement component 4 binding protein alpha	Homo sapiens	28-31
15844595-1	2005	OBJECTIVE: To investigate the codon-72 polymorphism of the tumor suppressor gene p53, codon-72 encodes arginine (Arg) or proline (Pro) for a genetic predisposition,to keloid or hypertrophic scar.	Proline	130-133	tumor protein p53	Homo sapiens	81-84
15485863-2	2004	We report here that the two leucines in the Leu-Glu-Met-Leu-Ala-Pro core motif of a 20-residue peptide corresponding to the sequence around Pro(564) in HIF-1alpha can be replaced by many residues with no or only a modest decrease in its substrate properties or in some cases even a slight increase.	Proline	64-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-162
15448155-1	2004	DPP-IV is a prolyl dipeptidase, cleaving the peptide bond after the penultimate proline residue.	Proline	80-87	dipeptidyl peptidase 4	Homo sapiens	0-6
15471880-2	2004	The proline-directed serine/threonine kinase cyclin-dependent kinase 5 (cdk5) plays an important role in diverse neuronal processes.	Proline	4-11	cyclin-dependent kinase 5	Mus musculus	45-70
15471880-2	2004	The proline-directed serine/threonine kinase cyclin-dependent kinase 5 (cdk5) plays an important role in diverse neuronal processes.	Proline	4-11	cyclin-dependent kinase 5	Mus musculus	72-76
15475353-7	2004	Interestingly the triple mutation (Phe(313(6.51)) to Tyr, Ile(6.53) to Thr, and Pro(7.33) to Thr) of V1aR increased sensitivity to VT but greatly reduced sensitivity to AVP, behaving like bfVT1R.	Proline	80-83	arginine vasopressin receptor 1A	Rattus norvegicus	101-105
15475353-9	2004	These results suggest that Phe/Tyr(6.51), Ile/Thr(6.53), and Pro/Thr(7.33) are responsible for the differential ligand selectivity between rat V1aR and bfVT1R.	Proline	61-64	arginine vasopressin receptor 1A	Rattus norvegicus	143-147
15574490-1	2004	The earliest folding events in single-tryptophan mutants of RNase A were investigated by fluorescence measurements by using a combination of stopped-flow and continuous-flow mixing experiments covering the time range from 70 micros to 10 s. An ultrarapid double-jump mixing protocol was used to study refolding from an unfolded ensemble containing only native proline isomers.	Proline	360-367	ribonuclease A family member 1, pancreatic	Homo sapiens	60-67
15574490-4	2004	These rapid conformational changes are not observed if RNase A is allowed to equilibrate under denaturing conditions, resulting in formation of nonnative proline isomers.	Proline	154-161	ribonuclease A family member 1, pancreatic	Homo sapiens	55-62
15588584-0	2004	Identification, expression analysis and polymorphism of a novel RLTPR gene encoding a RGD motif, tropomodulin domain and proline/leucine-rich regions.	Proline	121-128	capping protein regulator and myosin 1 linker 2	Homo sapiens	64-69
15575731-5	2004	Thus, the substitution of a proline residue on C-4 affects the trans/cis ratio by altering the pucker of its pyrrolidine ring.	Proline	28-35	complement C4A (Rodgers blood group)	Homo sapiens	47-50
15506981-6	2004	BPGAP1 is a novel RhoGAP that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 and Cdc42GAP homology domains serving as a homophilic/heterophilic interaction device, an enzymic RhoGAP domain that inactivates RhoA and a proline-rich region that binds the Src homology-3 domain of cortactin.	Proline	261-268	Rho GTPase activating protein 8	Homo sapiens	0-6
15526330-7	2004	To this end, we present the structure-activity characterization of three peptide analogues of the HIV gp160 processing site that all present mutations in proline at positions P3 and/or P2", while sharing the same N-terminal sequence, containing helix-breaking D-amino acids.	Proline	154-161	glutamyl aminopeptidase	Homo sapiens	102-107
15581617-7	2004	These results suggested that HNF4alpha and HNF1alpha regulate proline metabolism in adult liver.	Proline	62-69	hepatic nuclear factor 4, alpha	Mus musculus	29-38
15581617-7	2004	These results suggested that HNF4alpha and HNF1alpha regulate proline metabolism in adult liver.	Proline	62-69	HNF1 homeobox A	Mus musculus	43-52
15371422-5	2004	The integrity of the DNA-binding core domain, the N-terminal transactivation domain, and the C-terminal oligomerization domains of p53 was essential for hTERT promoter repression, whereas the proline-rich domain and the extreme C terminus were not required.	Proline	192-199	tumor protein p53	Homo sapiens	131-134
15768794-2	2004	Namely, it contains O-glycans and proline-rich peptides We previously observed underglycosylation of the hinge region in serum and deposited IgA1 in IgAN.	Proline	34-41	IGAN1	Homo sapiens	149-153
15506981-6	2004	BPGAP1 is a novel RhoGAP that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 and Cdc42GAP homology domains serving as a homophilic/heterophilic interaction device, an enzymic RhoGAP domain that inactivates RhoA and a proline-rich region that binds the Src homology-3 domain of cortactin.	Proline	261-268	BCL2 interacting protein 2	Homo sapiens	114-120
15506981-6	2004	BPGAP1 is a novel RhoGAP that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 and Cdc42GAP homology domains serving as a homophilic/heterophilic interaction device, an enzymic RhoGAP domain that inactivates RhoA and a proline-rich region that binds the Src homology-3 domain of cortactin.	Proline	261-268	Rho GTPase activating protein 1	Homo sapiens	125-133
15506981-6	2004	BPGAP1 is a novel RhoGAP that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 and Cdc42GAP homology domains serving as a homophilic/heterophilic interaction device, an enzymic RhoGAP domain that inactivates RhoA and a proline-rich region that binds the Src homology-3 domain of cortactin.	Proline	261-268	ras homolog family member A	Homo sapiens	250-254
15506981-6	2004	BPGAP1 is a novel RhoGAP that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 and Cdc42GAP homology domains serving as a homophilic/heterophilic interaction device, an enzymic RhoGAP domain that inactivates RhoA and a proline-rich region that binds the Src homology-3 domain of cortactin.	Proline	261-268	cortactin	Homo sapiens	321-330
15665420-2	2004	The metabolic product of TRH (cyclo-his-pro) retains physiological activity.	Proline	14-17	thyrotropin releasing hormone	Rattus norvegicus	25-28
15609125-1	2004	A functional polymorphism at codon 33 (leucine-to-proline, Leu33Pro)/nucleotide 1565 (T-to-C, T1565C) of the integrin beta3 has been hypothesized to increase the risk of breast cancer and its metastasis.	Proline	50-57	integrin subunit beta 3	Homo sapiens	109-123
15365822-2	2004	A recent report suggests that a polymorphism of the p53 tumor suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in the malignant transformation of colorectal adenoma to cancer.	Proline	116-123	tumor protein p53	Homo sapiens	52-55
15365822-2	2004	A recent report suggests that a polymorphism of the p53 tumor suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in the malignant transformation of colorectal adenoma to cancer.	Proline	116-123	tumor protein p53	Homo sapiens	179-182
15557176-4	2004	We report that 1) SHIP2 was tyrosine-phosphorylated in M-CSF-stimulated human alveolar macrophages, human THP-1 cells, murine macrophages, and the murine macrophage cell line RAW264; 2) SHIP2 associated with the M-CSF receptor after M-CSF stimulation; and 3) SHIP2 associated with the actin-binding protein filamin and localization to the cell membrane, requiring the proline-rich domain, but not on the Src homology 2 domain of SHIP2.	Proline	368-375	inositol polyphosphate phosphatase like 1	Homo sapiens	18-23
15375179-4	2004	Introduction of a central leucine to proline substitution abolished the alpha-helical structure of the peptide and disrupted apo(a) binding and inhibition of Lp(a) formation.	Proline	37-44	lipoprotein(a)	Homo sapiens	158-163
15537772-15	2004	As FI increased, the SID decreased linearly (P &lt; 0.04) for CP and all AA, except Arg, Trp, Asp, Pro, and Tyr.	Proline	99-102	FEEDIN	Sus scrofa	3-5
15579774-4	2004	We performed in vitro studies comparing the abilities of RIZ1 P704 polymorphic variants (homozygous presence, P704+; absence, P704-; heterozygosity P704(+/-) of a proline at position 704) to coactivate the ERalpha and also examined the polymorphism associated to BMD of 343 Swedish women, aged 20-39 yr.	Proline	163-170	PR/SET domain 2	Homo sapiens	57-61
15557176-4	2004	We report that 1) SHIP2 was tyrosine-phosphorylated in M-CSF-stimulated human alveolar macrophages, human THP-1 cells, murine macrophages, and the murine macrophage cell line RAW264; 2) SHIP2 associated with the M-CSF receptor after M-CSF stimulation; and 3) SHIP2 associated with the actin-binding protein filamin and localization to the cell membrane, requiring the proline-rich domain, but not on the Src homology 2 domain of SHIP2.	Proline	368-375	colony stimulating factor 1	Homo sapiens	55-60
15557176-6	2004	In contrast, the expression of a catalytically deficient mutant of SHIP2 or the proline-rich domain of SHIP2 enhanced Akt activation.	Proline	80-87	inositol polyphosphate phosphatase like 1	Homo sapiens	103-108
15557176-6	2004	In contrast, the expression of a catalytically deficient mutant of SHIP2 or the proline-rich domain of SHIP2 enhanced Akt activation.	Proline	80-87	AKT serine/threonine kinase 1	Homo sapiens	118-121
15564495-8	2004	Using a series of chimeric env genes, we could identify two determinants of high infectivity; one was an isoleucine to valine substitution at position 140 between variable regions A and B, and the other lies within the proline rich region.	Proline	219-226	endogenous retrovirus group K member 20	Homo sapiens	27-30
15599558-6	2004	The nucleotide C at SNP-A responsible for the amino acid exchange to proline could lead to the loss of a casein kinase II (CK2) phosphorylation site in the PGK2 peptide.	Proline	69-76	phosphoglycerate kinase 2	Sus scrofa	156-160
15582671-1	2004	The extracellular signal-regulated protein kinases (ERKs) are proline-directed, serine/threonine kinases that regulate a variety of cellular functions, including proliferation, differentiation, and plasticity.	Proline	62-69	mitogen activated protein kinase 1	Rattus norvegicus	52-56
15572843-4	2004	HRD1 co-localized with Pael-R in the ER and interacted with Pael-R through the proline-rich region of HRD1.	Proline	79-86	synoviolin 1	Homo sapiens	0-4
15572843-4	2004	HRD1 co-localized with Pael-R in the ER and interacted with Pael-R through the proline-rich region of HRD1.	Proline	79-86	G protein-coupled receptor 37	Homo sapiens	23-29
15572843-4	2004	HRD1 co-localized with Pael-R in the ER and interacted with Pael-R through the proline-rich region of HRD1.	Proline	79-86	G protein-coupled receptor 37	Homo sapiens	60-66
15572843-4	2004	HRD1 co-localized with Pael-R in the ER and interacted with Pael-R through the proline-rich region of HRD1.	Proline	79-86	synoviolin 1	Homo sapiens	102-106
15554700-4	2004	NMR spectroscopy of isotopically labeled Tip(140-191) revealed that the interaction with the LckSH3 domain is not restricted to the classical proline-rich motif, but also involves the C-terminally adjacent residues which pack into a hydrophobic pocket on the surface of the SH3 domain, thus playing a likely role in mediating binding specificity.	Proline	142-149	TOR signaling pathway regulator	Homo sapiens	41-44
15522098-2	2004	Pan1p, which binds several other endocytic proteins, is composed of multiple protein-protein interaction domains including two Eps15 Homology (EH) domains, a coiled-coil domain, an acidic Arp2/3-activating region, and a proline-rich domain.	Proline	220-227	Pan1p	Saccharomyces cerevisiae S288C	0-5
15375164-3	2004	This association occurs primarily via the cytoplasmic C-terminal proline-rich domain of Ror2.	Proline	65-72	receptor tyrosine kinase like orphan receptor 2	Homo sapiens	88-92
15607032-9	2004	Together, our data reveal that the amino acid residues Pro(500) and His(503) are critical for binding of PLC-gamma1 to one of its substrates, PI(4,5)P(2) in the membrane.	Proline	55-58	phospholipase C gamma 1	Homo sapiens	105-115
15355990-3	2004	Etk is physically associated with p53 through its Src homology 3 domain and the proline-rich domain of p53.	Proline	80-87	BMX non-receptor tyrosine kinase	Homo sapiens	0-3
15355990-3	2004	Etk is physically associated with p53 through its Src homology 3 domain and the proline-rich domain of p53.	Proline	80-87	tumor protein p53	Homo sapiens	34-37
15355990-3	2004	Etk is physically associated with p53 through its Src homology 3 domain and the proline-rich domain of p53.	Proline	80-87	tumor protein p53	Homo sapiens	103-106
15375164-6	2004	Site-directed mutagenesis of tyrosine residues in Ror2 reveals that the sites of phosphorylation are contained among the five tyrosine residues in the proline-rich domain but not among the four tyrosine residues in the tyrosine kinase domain.	Proline	151-158	receptor tyrosine kinase like orphan receptor 2	Homo sapiens	50-54
15375171-0	2004	Involvement of the C-terminal proline-rich motif of G protein-coupled receptor kinases in recognition of activated rhodopsin.	Proline	30-37	rhodopsin	Homo sapiens	115-124
15375171-7	2004	Through a series of mutagenesis analyses, a proline-rich motif in the CC was identified as the key element involved in the interaction between the CC region and rhodopsin.	Proline	44-51	rhodopsin	Homo sapiens	161-170
15548692-3	2004	The Wwox protein contains two WW domains that typically bind proline-rich motifs and mediate protein-protein interactions.	Proline	61-68	WW domain containing oxidoreductase	Homo sapiens	4-8
15364934-4	2004	We found that PP4 interacted with HPK1 and that the proline-rich region of HPK1 was necessary and sufficient for this interaction.	Proline	52-59	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	75-79
15385562-5	2004	Three of the Pax-5 isoforms generate novel protein sequences rich in proline, serine, and threonine amino acids that are the hallmarks of transactivation domains.	Proline	69-76	paired box 5	Homo sapiens	13-18
15358789-7	2004	The N-terminal proline is required for the degradation of FBPase and MDH2 for both the vacuolar and non-vacuolar proteolytic pathways.	Proline	15-22	malate dehydrogenase 2	Homo sapiens	69-73
15548692-9	2004	Alterations of tyrosine 33 in the first WW domain of Wwox or the proline-rich motif in AP-2gamma dramatically reduce this interaction.	Proline	65-72	transcription factor AP-2 gamma	Homo sapiens	87-96
15342635-1	2004	The complex of Cdk5 and its neuronal activator p35 is a proline-directed Ser/Thr kinase that plays an important role in various neuronal functions.	Proline	56-63	cyclin dependent kinase 5	Homo sapiens	15-19
15510217-2	2004	We have now identified the small proline-rich repeat proteins (SPRR) 1A and 2A as downstream targets of gp130 signaling that are strongly induced in cardiomyocytes responding to biomechanical/ischemic stress.	Proline	33-40	interleukin 6 cytokine family signal transducer	Rattus norvegicus	104-109
15328344-3	2004	We identified 35 amino acid residues in the proline- and serine-rich N-terminal region (called minimal transactivation domain, MTD), which, when combined with LexA or Gal4 DNA binding domains, exhibited activation of target promoters.	Proline	44-51	galectin 4	Bos taurus	167-171
15526038-1	2004	Functional localization of acetylcholinesterase (AChE) in vertebrate muscle and brain depends on interaction of the tryptophan amphiphilic tetramerization (WAT) sequence, at the C-terminus of its major splice variant (T), with a proline-rich attachment domain (PRAD), of the anchoring proteins, collagenous (ColQ) and proline-rich membrane anchor.	Proline	229-236	acetylcholinesterase (Cartwright blood group)	Homo sapiens	27-47
15526038-1	2004	Functional localization of acetylcholinesterase (AChE) in vertebrate muscle and brain depends on interaction of the tryptophan amphiphilic tetramerization (WAT) sequence, at the C-terminus of its major splice variant (T), with a proline-rich attachment domain (PRAD), of the anchoring proteins, collagenous (ColQ) and proline-rich membrane anchor.	Proline	229-236	acetylcholinesterase (Cartwright blood group)	Homo sapiens	49-53
15526038-1	2004	Functional localization of acetylcholinesterase (AChE) in vertebrate muscle and brain depends on interaction of the tryptophan amphiphilic tetramerization (WAT) sequence, at the C-terminus of its major splice variant (T), with a proline-rich attachment domain (PRAD), of the anchoring proteins, collagenous (ColQ) and proline-rich membrane anchor.	Proline	318-325	acetylcholinesterase (Cartwright blood group)	Homo sapiens	27-47
15526038-1	2004	Functional localization of acetylcholinesterase (AChE) in vertebrate muscle and brain depends on interaction of the tryptophan amphiphilic tetramerization (WAT) sequence, at the C-terminus of its major splice variant (T), with a proline-rich attachment domain (PRAD), of the anchoring proteins, collagenous (ColQ) and proline-rich membrane anchor.	Proline	318-325	acetylcholinesterase (Cartwright blood group)	Homo sapiens	49-53
15342635-1	2004	The complex of Cdk5 and its neuronal activator p35 is a proline-directed Ser/Thr kinase that plays an important role in various neuronal functions.	Proline	56-63	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	47-50
15511625-6	2004	As a result, proline 343 localised within the highly conserved transmembrane segment S6 of the KCNQ1 channel is replaced by a serine.	Proline	13-20	potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog	Xenopus laevis	95-100
15465019-2	2004	Overlay studies demonstrate that LASP-1 directly binds to the proline-rich domains of zyxin, lipoma preferred partner (LPP), and vasodilator-stimulated phosphoprotein (VASP), with zyxin being the most prominent interacting partner.	Proline	62-69	LIM and SH3 protein 1	Mus musculus	33-39
15465019-2	2004	Overlay studies demonstrate that LASP-1 directly binds to the proline-rich domains of zyxin, lipoma preferred partner (LPP), and vasodilator-stimulated phosphoprotein (VASP), with zyxin being the most prominent interacting partner.	Proline	62-69	zyxin	Mus musculus	86-91
15465019-2	2004	Overlay studies demonstrate that LASP-1 directly binds to the proline-rich domains of zyxin, lipoma preferred partner (LPP), and vasodilator-stimulated phosphoprotein (VASP), with zyxin being the most prominent interacting partner.	Proline	62-69	LIM domain containing preferred translocation partner in lipoma	Mus musculus	93-117
15509157-0	2004	A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors.	Proline	39-46	prolyl endopeptidase	Homo sapiens	69-90
15465019-2	2004	Overlay studies demonstrate that LASP-1 directly binds to the proline-rich domains of zyxin, lipoma preferred partner (LPP), and vasodilator-stimulated phosphoprotein (VASP), with zyxin being the most prominent interacting partner.	Proline	62-69	zyxin	Mus musculus	180-185
15506738-1	2004	The mechanisms, transition structures, regioselectivity, and stereoselectivity of proline-catalyzed alpha-aminoxylation reactions were studied with density functional theory (B3LYP/6-31G(d)).	Proline	82-89	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	177-180
15509157-1	2004	With the aim to replace the natural amino acid proline by a proline mimetic structure, a cyclopent-2-enecarbonyl moiety was studied at the P2 position of prolyl oligopeptidase (POP) inhibitors.	Proline	60-67	prolyl endopeptidase	Homo sapiens	154-175
15509157-2	2004	The cyclopent-2-enecarbonyl moiety proved to be an excellent proline mimetic at the P2 position of POP inhibitors.	Proline	61-68	prolyl endopeptidase	Homo sapiens	99-102
15531314-13	2004	CONCLUSION: Because serine 73 is conserved in the mouse ortholog and other discoidin proteins, the proline 73 allele is therefore very likely to encode a defective retinoschisin.	Proline	99-106	retinoschisis (X-linked, juvenile) 1 (human)	Mus musculus	164-177
15525469-12	2004	At the same concentration Pro-Pro-hGHRH (1-44)-Gly-Gly-Cys stimulated more GH release than Pro-Pro-hGHRH (1-44)OH.	Proline	26-29	growth hormone releasing hormone	Homo sapiens	34-39
15525469-12	2004	At the same concentration Pro-Pro-hGHRH (1-44)-Gly-Gly-Cys stimulated more GH release than Pro-Pro-hGHRH (1-44)OH.	Proline	26-29	growth hormone 1	Homo sapiens	35-37
15271661-4	2004	In the present study, we tested the following hypotheses: 1) rat carotid artery injury induces the expression of PTP-1B, Src homology-2 domain phosphatase (SHP-2), and PTP-proline, glutamate, serine, and threonine sequence (PEST) protein; and 2) polypeptide growth factors as well as ANG II increase the levels of tyrosine phosphatases in cultured rat aortic smooth muscle cells.	Proline	172-179	angiotensinogen	Rattus norvegicus	284-290
15353242-1	2004	Previously it was found that proproteins for basic and glycosylated salivary proline-rich proteins (PRP) were cleaved prior to secretion from cells by furin, a well-known convertase.	Proline	77-84	furin, paired basic amino acid cleaving enzyme	Homo sapiens	151-156
15533911-1	2004	A polymorphism at codon 72 of the human tumor suppressor p53 determines translation into either arginine or proline.	Proline	108-115	tumor protein p53	Homo sapiens	57-60
15700540-0	2004	Dynamic changes in intranuclear and subcellular localizations of mouse Prrp/DAZAP1 during spermatogenesis: the necessity of the C-terminal proline-rich region for nuclear import and localization.	Proline	139-146	prolactin releasing hormone L homeolog	Xenopus laevis	71-75
15549182-10	2004	C-peptide stimulated phosphorylation of human Na(+), K(+)-ATPase alpha subunit on Thr-Pro amino acid motifs, which form specific ERK substrates.	Proline	86-89	mitogen-activated protein kinase 3	Homo sapiens	129-132
15240512-5	2004	The p53 codon 72 proline allele carriers were found to be more susceptible to progress to GC than to IM (OR = 2.22, 95%CI = 1.05-4.70, P = 0.038).	Proline	17-24	tumor protein p53	Homo sapiens	4-7
15345686-7	2004	PAT-mediated uptake of radiolabeled proline was also dose-dependently reduced by SCFA and could be described by first order competition kinetics with apparent Ki-values for butyrate of 6.0 +/- 0.7 and 7.6 +/- 1.3 mM for PAT1 and PAT2, respectively.	Proline	36-43	amyloid beta precursor protein binding protein 2	Homo sapiens	220-224
15479192-5	2004	The SDHD mutation was a C to T transition within codon 81 causing substitution of proline with leucine (P81L).	Proline	82-89	succinate dehydrogenase complex subunit D	Homo sapiens	4-8
15560799-3	2004	MALDI-TOF MS revealed that T800 contains the entire titin PEVK (Pro, Glu, Val, Lys-rich) domain.	Proline	64-67	titin	Homo sapiens	52-57
15345686-7	2004	PAT-mediated uptake of radiolabeled proline was also dose-dependently reduced by SCFA and could be described by first order competition kinetics with apparent Ki-values for butyrate of 6.0 +/- 0.7 and 7.6 +/- 1.3 mM for PAT1 and PAT2, respectively.	Proline	36-43	solute carrier family 36 member 2	Homo sapiens	229-233
15313476-6	2004	Each peptide sequenced was found to be present in the primary structure of seprase/fibroblast activation protein (FAP), a serine gelatinase specific for proline-containing peptides and macromolecules.	Proline	153-160	fibroblast activation protein alpha	Homo sapiens	75-82
15313476-6	2004	Each peptide sequenced was found to be present in the primary structure of seprase/fibroblast activation protein (FAP), a serine gelatinase specific for proline-containing peptides and macromolecules.	Proline	153-160	fibroblast activation protein alpha	Homo sapiens	114-117
15496163-3	2004	Barttin bears a proline-tyrosine motif, a target structure for the ubiquitin ligase Nedd4-2, which mediates the clearance of channel proteins from the cell membrane.	Proline	16-23	barttin CLCNK-type chloride channel accessory beta subunit S homeolog	Xenopus laevis	0-7
15477360-3	2004	Spergen-3 encodes a 75-kDa soluble protein bearing putative 2 EF-hand motifs, proline-repeat, and a putative nuclear localization signal.	Proline	78-85	spermatogenesis associated 21	Rattus norvegicus	0-9
15531543-7	2004	A new inactivating heterozygous mutation was found in the proband and the mother of family B and consisted of the substitution of a leucine in place of a highly conserved proline at position 252 (L252P) in the extracellular portion of the TSHr.	Proline	171-178	thyroid stimulating hormone receptor	Bos taurus	239-243
15549155-4	2004	Suspicion of 11 beta-hydroxylase deficiency led to DNA mutation analysis, which revealed a novel point mutation (CTG 461 CCG) in the CYP11B1 gene converting leucine to proline.	Proline	168-175	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	133-140
15389839-5	2004	The human MAPKAPK2 predicted protein contains 14 additional amino acids in the proline-rich N-terminal domain, when compared to murine and rat MAPKAPK2 predicted proteins.	Proline	79-86	MAPK activated protein kinase 2	Homo sapiens	10-18
15483243-7	2004	Interestingly, deletion of the proline-rich C-terminal domain (aa 101-112) of Vpx, which is important for nuclear localization, resulted in loss of interaction with alpha-actinin 1.	Proline	31-38	vpx protein	Simian immunodeficiency virus	78-81
15483243-7	2004	Interestingly, deletion of the proline-rich C-terminal domain (aa 101-112) of Vpx, which is important for nuclear localization, resulted in loss of interaction with alpha-actinin 1.	Proline	31-38	actinin alpha 1	Homo sapiens	165-180
15479836-7	2004	Analysis of c-Myc- and E2F1-mediated inhibition of a panel of Zta mutants shows parallel genetics and inhibition maps to a small bipartite sequence located between amino acids 29 and 53 of Zta, containing homology to the proline-rich domain of the tumor suppressor protein p53.	Proline	221-228	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	12-17
15479836-7	2004	Analysis of c-Myc- and E2F1-mediated inhibition of a panel of Zta mutants shows parallel genetics and inhibition maps to a small bipartite sequence located between amino acids 29 and 53 of Zta, containing homology to the proline-rich domain of the tumor suppressor protein p53.	Proline	221-228	E2F transcription factor 1	Homo sapiens	23-27
15479836-7	2004	Analysis of c-Myc- and E2F1-mediated inhibition of a panel of Zta mutants shows parallel genetics and inhibition maps to a small bipartite sequence located between amino acids 29 and 53 of Zta, containing homology to the proline-rich domain of the tumor suppressor protein p53.	Proline	221-228	tumor protein p53	Homo sapiens	273-276
15496163-3	2004	Barttin bears a proline-tyrosine motif, a target structure for the ubiquitin ligase Nedd4-2, which mediates the clearance of channel proteins from the cell membrane.	Proline	16-23	NEDD4 like E3 ubiquitin protein ligase S homeolog	Xenopus laevis	84-91
15491364-0	2004	A proline tRNA(CGG) gene encompassing the attachment site of temperate phage 16-3 is functional and convertible to suppressor tRNA.	Proline	2-9	AWN88_RS22725	Agrobacterium tumefaciens	10-14
15491364-0	2004	A proline tRNA(CGG) gene encompassing the attachment site of temperate phage 16-3 is functional and convertible to suppressor tRNA.	Proline	2-9	AWN88_RS22725	Agrobacterium tumefaciens	126-130
15491364-3	2004	In this article, we demonstrate that the attachment site of temperate phage 16-3 (attB) nests within an active proline tRNA gene in Rhizobium meliloti 41.	Proline	111-118	AWN88_RS22725	Agrobacterium tumefaciens	119-123
15491364-6	2004	Upon lysogenization of R. meliloti by phage 16-3, the proline tRNA gene retained its structural and functional integrity.	Proline	54-61	AWN88_RS22725	Agrobacterium tumefaciens	62-66
15634502-13	2004	CONCLUSIONS: In northern Chinese women, p53 codon 72 Pro/Arg and p53 PIN3 gene polymorphisms are not associated with development of ovarian cancer.	Proline	53-56	tumor protein p53	Homo sapiens	40-43
15474361-1	2004	The peptidyl-prolyl cis-trans isomerase (PPIase) Pin1 modulates the activity of a range of target proteins involved in the cell cycle, transcription, translation, endocytosis, and apoptosis by facilitating dephosphorylation of phosphorylated serine or threonine residue preceding a proline (p-Ser/Thr-Pro) motifs catalyzed by phosphatases specific for the trans conformations.	Proline	282-289	peptidylprolyl isomerase like 1	Homo sapiens	4-39
15474361-1	2004	The peptidyl-prolyl cis-trans isomerase (PPIase) Pin1 modulates the activity of a range of target proteins involved in the cell cycle, transcription, translation, endocytosis, and apoptosis by facilitating dephosphorylation of phosphorylated serine or threonine residue preceding a proline (p-Ser/Thr-Pro) motifs catalyzed by phosphatases specific for the trans conformations.	Proline	282-289	peptidylprolyl isomerase like 1	Homo sapiens	41-47
15474361-1	2004	The peptidyl-prolyl cis-trans isomerase (PPIase) Pin1 modulates the activity of a range of target proteins involved in the cell cycle, transcription, translation, endocytosis, and apoptosis by facilitating dephosphorylation of phosphorylated serine or threonine residue preceding a proline (p-Ser/Thr-Pro) motifs catalyzed by phosphatases specific for the trans conformations.	Proline	282-289	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	49-53
15388904-5	2004	It has been demonstrated that PI3-K/Akt and downstream phosphorylated Bad and proline-rich Akt substrate survival signaling cascades are upregulated in surviving neurons in the ischemic brain that overexpresses copper-zinc superoxide dismutase activity.	Proline	78-85	AKT serine/threonine kinase 1	Homo sapiens	36-39
15388904-5	2004	It has been demonstrated that PI3-K/Akt and downstream phosphorylated Bad and proline-rich Akt substrate survival signaling cascades are upregulated in surviving neurons in the ischemic brain that overexpresses copper-zinc superoxide dismutase activity.	Proline	78-85	AKT serine/threonine kinase 1	Homo sapiens	91-94
15570475-6	2004	At 35 degrees C, there were also high levels of choline and proline due to the activation of Delta1-pyrroline-5-carboxylate synthetase (P5CS) and ornithine aminotransferase (OAT), and simultaneous inhibition of proline dehydrogenase (PDH) and proline oxidase (PO).	Proline	60-67	delta-1-pyrroline-5-carboxylate synthase	Solanum lycopersicum	99-134
15570475-6	2004	At 35 degrees C, there were also high levels of choline and proline due to the activation of Delta1-pyrroline-5-carboxylate synthetase (P5CS) and ornithine aminotransferase (OAT), and simultaneous inhibition of proline dehydrogenase (PDH) and proline oxidase (PO).	Proline	60-67	delta-1-pyrroline-5-carboxylate synthase	Solanum lycopersicum	136-140
15380217-1	2004	In-house screening of the Merck sample collection identified proline derived homophenylalanine 3 as a DPP-IV inhibitor with modest potency (DPP-IV IC50=1.9 microM).	Proline	61-68	dipeptidyl peptidase 4	Homo sapiens	102-108
15310755-5	2004	A proline-rich region (amino acids 796-807) is critical for maintaining AIP1 in a closed form, which associates with a region of TNFR1 distinct from the death domain, the site of TNFR1 association with TRADD.	Proline	2-9	DAB2 interacting protein	Homo sapiens	72-76
15310755-5	2004	A proline-rich region (amino acids 796-807) is critical for maintaining AIP1 in a closed form, which associates with a region of TNFR1 distinct from the death domain, the site of TNFR1 association with TRADD.	Proline	2-9	TNF receptor superfamily member 1A	Homo sapiens	129-134
15310755-5	2004	A proline-rich region (amino acids 796-807) is critical for maintaining AIP1 in a closed form, which associates with a region of TNFR1 distinct from the death domain, the site of TNFR1 association with TRADD.	Proline	2-9	TNF receptor superfamily member 1A	Homo sapiens	179-184
15310755-5	2004	A proline-rich region (amino acids 796-807) is critical for maintaining AIP1 in a closed form, which associates with a region of TNFR1 distinct from the death domain, the site of TNFR1 association with TRADD.	Proline	2-9	TNFRSF1A associated via death domain	Homo sapiens	202-207
15380217-1	2004	In-house screening of the Merck sample collection identified proline derived homophenylalanine 3 as a DPP-IV inhibitor with modest potency (DPP-IV IC50=1.9 microM).	Proline	61-68	dipeptidyl peptidase 4	Homo sapiens	140-146
15310755-6	2004	An AIP1 mutant with deletion of this proline-rich region constitutively binds to TRAF2 and ASK1.	Proline	37-44	DAB2 interacting protein	Homo sapiens	3-7
15272021-6	2004	Other mutations, which bring about a significant decrease in PlGF binding activity, are Gln-27, located in the N-terminal alpha-helix, and Pro-98 and Tyr-100 on the beta6 strand.	Proline	139-142	placental growth factor	Homo sapiens	61-65
15310755-6	2004	An AIP1 mutant with deletion of this proline-rich region constitutively binds to TRAF2 and ASK1.	Proline	37-44	TNF receptor associated factor 2	Homo sapiens	81-86
15310755-6	2004	An AIP1 mutant with deletion of this proline-rich region constitutively binds to TRAF2 and ASK1.	Proline	37-44	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	91-95
15385169-7	2004	Three protein-protein interaction domains were identified in enkurin: a C-terminal region is essential for channel interaction; an IQ motif binds the Ca2+ sensor, calmodulin, in a Ca2+-dependent manner; and a proline-rich N-terminal region contains predicted ligand sequences for SH3 domain proteins, including the SH3 domain of the p85 regulatory subunit of 1-phosphatidylinositol-3-kinase.	Proline	209-216	enkurin, TRPC channel interacting protein	Homo sapiens	61-68
15351706-6	2004	Mutational analysis demonstrated that the GS domain of the receptor and the conserved proline-rich domain of SAP49 were required for the interaction.	Proline	86-93	splicing factor 3b subunit 4	Homo sapiens	109-114
15470053-4	2004	Previous studies suggest that the proline-rich domain (aa 43-70) in FasLCyt (FasLPRD) inhibits FasL membrane expression by retaining FasL in the secretory lysosomes.	Proline	34-41	Fas ligand	Homo sapiens	68-72
15470053-4	2004	Previous studies suggest that the proline-rich domain (aa 43-70) in FasLCyt (FasLPRD) inhibits FasL membrane expression by retaining FasL in the secretory lysosomes.	Proline	34-41	Fas ligand	Homo sapiens	77-81
15470053-7	2004	In addition, retention of proline-rich domain-containing FasL in the cytoplasm was not observed.	Proline	26-33	Fas ligand	Homo sapiens	57-61
15453706-0	2004	ACE-inhibitory activity and structural properties of peptide Asp-Lys-Ile-His-Pro [beta-CN f(47-51)].	Proline	77-80	angiotensin I converting enzyme	Homo sapiens	0-3
15449943-10	2004	Our results suggest that the molecular basis for increased plasma proline levels in schizophrenic subjects carrying the missense mutation L441P is due to decreased stability of human PRODH2.	Proline	66-73	proline dehydrogenase 2	Homo sapiens	183-189
15448205-7	2004	Transformation in these assays, and activation of the downstream effector molecules PLC-gamma, STAT5, and phosphatidylinositol 3-kinase/AKT, required the proline-rich domains, but not the ZNF domains, of ZNF198.	Proline	154-161	AKT serine/threonine kinase 1	Homo sapiens	136-139
15453706-2	2004	Some of the most potent ACE-inhibitory peptides described in food have a proline at the end of their sequence, a characteristic that can cause problems in the synthesis procedures.	Proline	73-80	angiotensin I converting enzyme	Homo sapiens	24-27
15474075-11	2004	It appears that the negative feedback effect of AHRR on dioxin-related signaling is weaker for the proline allele than for the alanine allele, and that the hypomorphic function of the proline allele exerts a recessive adverse effect on male fertility.	Proline	99-106	aryl hydrocarbon receptor repressor	Homo sapiens	48-52
15372531-7	2004	The single base mutation caused the substitution of a conserved leucine at 502 position to proline in transmembrane helix (TM) IV of the hLHR.	Proline	91-98	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	137-141
15467463-1	2004	Among the Bcl-2 family, myeloid cell leukemia-1 (Mcl-1) distinguishes itself from the other pro-survival proteins by its ability to oppose to a wide variety of pro-apoptotic stimuli, short half-life, and presence of polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) domains (PEST).	Proline	250-257	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	24-47
15467463-1	2004	Among the Bcl-2 family, myeloid cell leukemia-1 (Mcl-1) distinguishes itself from the other pro-survival proteins by its ability to oppose to a wide variety of pro-apoptotic stimuli, short half-life, and presence of polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) domains (PEST).	Proline	250-257	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	49-54
15469846-4	2004	RIAM defines a family of adaptor molecules that contain a RA-like (Ras association) domain, a PH (pleckstrin homology) domain, and various proline-rich motifs.	Proline	139-146	amyloid beta precursor protein binding family B member 1 interacting protein	Homo sapiens	0-4
15474075-11	2004	It appears that the negative feedback effect of AHRR on dioxin-related signaling is weaker for the proline allele than for the alanine allele, and that the hypomorphic function of the proline allele exerts a recessive adverse effect on male fertility.	Proline	184-191	aryl hydrocarbon receptor repressor	Homo sapiens	48-52
15375776-3	2004	The substrates of CD26/DPPIV are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides.	Proline	33-40	dipeptidyl peptidase 4	Homo sapiens	18-22
15375776-3	2004	The substrates of CD26/DPPIV are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides.	Proline	33-40	dipeptidyl peptidase 4	Homo sapiens	23-28
15280379-5	2004	They encode alternatively spliced isoforms of Eve-1, called Eve-1a and Eve-1b, that have four and five tandem Src homology 3 (SH3) domains in the carboxyl-terminal region, respectively, and seven proline-rich SH3 domain binding motifs in the amino-terminal region.	Proline	196-203	SH3 domain containing 19	Homo sapiens	46-51
15475297-4	2004	The domains found in Graal proteins are: chitin-binding domains (CBD), scavenger receptor cysteine-rich (SRCR) domains, low density lipoprotein receptor cysteine-rich (LDLR-CR) domains, histidine and proline-rich domains, a NGGYQPP-repeat domain and a serine protease domain.	Proline	200-207	Tequila	Drosophila melanogaster	21-26
15672606-0	2004	A new set of monoclonal antibodies directed to proline-rich and central regions of p53.	Proline	47-54	tumor protein p53	Homo sapiens	83-86
15672606-5	2004	The H53C2 and H53C3 MAbs are against different epitopes within the proline-rich region of p53.	Proline	67-74	tumor protein p53	Homo sapiens	90-93
15247294-11	2004	Co-expression of CIITA with deletion mutations and collagen promoter constructs demonstrates that CIITA represses collagen promoter mainly through its N-terminal region including the acidic domain and the proline/serine/threonine domain.	Proline	205-212	class II major histocompatibility complex transactivator	Homo sapiens	98-103
15465778-3	2004	L-arginine is catabolized by arginases, nitric oxide synthases, arginine:glycine amidinotransferase, and possibly also by arginine decarboxylase, resulting ultimately in the production of urea, proline, glutamate, polyamines, nitric oxide, creatine, or agmatine.	Proline	194-201	antizyme inhibitor 2	Homo sapiens	122-144
15361141-3	2004	Biochemical analysis in yeast showed that AtLHT2 transports proline and aspartate with high affinity.	Proline	60-67	lysine histidine transporter 2	Arabidopsis thaliana	42-48
15357668-11	2004	In particular, an R4-S7 beta-turn is present in similar proportions in both conformation C of IP01 and in IP02-K6; this motif is important in binding to ICAM-1 because this turn enables the IP02-K6 backbone to drape over proline-36 on ICAM-1.	Proline	221-228	intercellular adhesion molecule 1	Mus musculus	153-159
15357668-11	2004	In particular, an R4-S7 beta-turn is present in similar proportions in both conformation C of IP01 and in IP02-K6; this motif is important in binding to ICAM-1 because this turn enables the IP02-K6 backbone to drape over proline-36 on ICAM-1.	Proline	221-228	intercellular adhesion molecule 1	Mus musculus	235-241
15361141-4	2004	However, other neutral and acidic amino acids act as strong competitors for proline and aspartate uptake indicating that AtLHT2 generally transports uncharged and negatively charged amino acids.	Proline	76-83	lysine histidine transporter 2	Arabidopsis thaliana	121-127
15271983-3	2004	It was shown recently that hydroxylation of prolines in the HIFalpha subunit of HIF-1 is required for its binding with the von Hippel-Lindau tumor suppressor protein and the subsequent proteasomal destruction.	Proline	44-52	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-85
15252041-1	2004	Glycogen synthase kinase (GSK)-3beta is a constitutively active, proline-directed serine/threonine kinase that controls growth modulation and tumorigenesis through multiple intracellular signaling pathways.	Proline	65-72	glycogen synthase kinase 3 beta	Mus musculus	0-36
15217351-1	2004	POP (prolyl oligopeptidase) specifically hydrolyses a number of small proline-containing peptides at the carboxy end of the proline residue and POP inhibitors have been shown to have cognition-enhancing properties.	Proline	70-77	prolyl endopeptidase	Homo sapiens	0-3
15262986-9	2004	Together, these findings suggest that p53 acts upstream of Bax to promote MDA-mediated cell death in a proline-rich domain-dependent manner through both transcription-dependent (by up-regulating PUMA expression) and -independent mechanisms in human colon cancer HCT116 cells.	Proline	103-110	tumor protein p53	Homo sapiens	38-41
15262986-9	2004	Together, these findings suggest that p53 acts upstream of Bax to promote MDA-mediated cell death in a proline-rich domain-dependent manner through both transcription-dependent (by up-regulating PUMA expression) and -independent mechanisms in human colon cancer HCT116 cells.	Proline	103-110	BCL2 associated X, apoptosis regulator	Homo sapiens	59-62
15217351-1	2004	POP (prolyl oligopeptidase) specifically hydrolyses a number of small proline-containing peptides at the carboxy end of the proline residue and POP inhibitors have been shown to have cognition-enhancing properties.	Proline	70-77	prolyl endopeptidase	Homo sapiens	5-26
15217351-1	2004	POP (prolyl oligopeptidase) specifically hydrolyses a number of small proline-containing peptides at the carboxy end of the proline residue and POP inhibitors have been shown to have cognition-enhancing properties.	Proline	70-77	prolyl endopeptidase	Homo sapiens	144-147
15217351-1	2004	POP (prolyl oligopeptidase) specifically hydrolyses a number of small proline-containing peptides at the carboxy end of the proline residue and POP inhibitors have been shown to have cognition-enhancing properties.	Proline	124-131	prolyl endopeptidase	Homo sapiens	0-3
15217351-1	2004	POP (prolyl oligopeptidase) specifically hydrolyses a number of small proline-containing peptides at the carboxy end of the proline residue and POP inhibitors have been shown to have cognition-enhancing properties.	Proline	124-131	prolyl endopeptidase	Homo sapiens	5-26
15313630-11	2004	Furthermore, the mutation by Tyr of two proline residues in APP-RP1, which are essential for the binding of some linear peptides to Abl-SH3, demonstrates the effectiveness of the scaffold in enhancing the variability in the design of high-affinity and high-specificity ligands for any SH3 domain.	Proline	40-47	RP1 axonemal microtubule associated	Homo sapiens	64-67
15231847-7	2004	AMAP2 was moreover found to bind to amphiphysin IIm, a component of the endocytic machinery, via its proline-rich domain.	Proline	101-108	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	Homo sapiens	0-5
15254019-3	2004	This SNP, which converts a conserved proline residue in FAAH to threonine (P129T), suggests a potential role for the FAAH-endocannabinoid system in regulating addictive behavior.	Proline	37-44	fatty acid amide hydrolase	Homo sapiens	56-60
15254019-3	2004	This SNP, which converts a conserved proline residue in FAAH to threonine (P129T), suggests a potential role for the FAAH-endocannabinoid system in regulating addictive behavior.	Proline	37-44	fatty acid amide hydrolase	Homo sapiens	117-121
15371500-5	2004	Activation of IKK is likely mediated by direct interaction with mutant Htt, because the expanded polyglutamine stretch and adjacent proline-rich motifs in mutant Htt interact with IKKgamma, a regulatory subunit of IKK.	Proline	132-139	inhibitor of kappaB kinase gamma	Mus musculus	14-17
15371500-5	2004	Activation of IKK is likely mediated by direct interaction with mutant Htt, because the expanded polyglutamine stretch and adjacent proline-rich motifs in mutant Htt interact with IKKgamma, a regulatory subunit of IKK.	Proline	132-139	huntingtin	Mus musculus	71-74
15371500-5	2004	Activation of IKK is likely mediated by direct interaction with mutant Htt, because the expanded polyglutamine stretch and adjacent proline-rich motifs in mutant Htt interact with IKKgamma, a regulatory subunit of IKK.	Proline	132-139	huntingtin	Mus musculus	162-165
15371500-5	2004	Activation of IKK is likely mediated by direct interaction with mutant Htt, because the expanded polyglutamine stretch and adjacent proline-rich motifs in mutant Htt interact with IKKgamma, a regulatory subunit of IKK.	Proline	132-139	inhibitor of kappaB kinase gamma	Mus musculus	180-188
15371500-5	2004	Activation of IKK is likely mediated by direct interaction with mutant Htt, because the expanded polyglutamine stretch and adjacent proline-rich motifs in mutant Htt interact with IKKgamma, a regulatory subunit of IKK.	Proline	132-139	inhibitor of kappaB kinase gamma	Mus musculus	180-183
15226305-4	2004	Two proline-rich domains located amino-terminal to the homeodomain (Pro1 and Pro2) are necessary for Alx3-dependent transactivation, whereas another one (Pro3) located in the carboxyl terminus is dispensable but contributes to enhance the magnitude of the response.	Proline	4-11	ALX homeobox 3	Rattus norvegicus	101-105
15306180-2	2004	The GPVI gene is polymorphic with several SNPs and the T13254C polymorphism predicting amino acid substitution (serine to proline) has been associated with the risk of MI in a preliminary study.	Proline	122-129	glycoprotein VI platelet	Homo sapiens	4-8
15313630-11	2004	Furthermore, the mutation by Tyr of two proline residues in APP-RP1, which are essential for the binding of some linear peptides to Abl-SH3, demonstrates the effectiveness of the scaffold in enhancing the variability in the design of high-affinity and high-specificity ligands for any SH3 domain.	Proline	40-47	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	132-135
16194880-1	2004	Using truncated or mutated alphaIIb integrin cytoplasmic domains fused to the alphaV extracellular domain and expressed with the beta3 integrin subunit, we demonstrate that the double mutation of proline residues 998 and 999 to alanine (PP998/999AA), previously shown to disturb the C-terminal conformation of the alphaIIb integrin cytoplasmic domain, prevents tyrosine phosphorylation of beta3 integrin induced by Arg-Gly-Asp peptide ligation.	Proline	196-203	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	129-134
15131588-1	2004	A common arginine to proline polymorphism is harboured at codon 72 of the human p53 gene.	Proline	21-28	tumor protein p53	Homo sapiens	80-83
15350301-4	2004	These polymorphisms are found within the oxygen-dependent degradation domain of the HIF-1alpha protein and may be important in the oxygen regulation of the protein via hydroxylation of the proline residue at position 564 (P564) by HIF-alpha prolyl hydroxylase (HIF-PH).	Proline	189-196	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-94
16194880-1	2004	Using truncated or mutated alphaIIb integrin cytoplasmic domains fused to the alphaV extracellular domain and expressed with the beta3 integrin subunit, we demonstrate that the double mutation of proline residues 998 and 999 to alanine (PP998/999AA), previously shown to disturb the C-terminal conformation of the alphaIIb integrin cytoplasmic domain, prevents tyrosine phosphorylation of beta3 integrin induced by Arg-Gly-Asp peptide ligation.	Proline	196-203	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	389-394
15327482-8	2004	Insertion of each novel exon results in production of a premature termination codon, respectively, and the predicted proteins generated from them have only a proline-rich domain and an incomplete DH domain which potentially compete with the wild type of FGD1.	Proline	158-165	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	254-258
15353287-8	2004	The structures of CyP in complex with proline-containing peptides provided insight into the mechanism of peptidyl-prolyl cis-trans isomerization.	Proline	38-45	peptidylprolyl isomerase G	Homo sapiens	18-21
15365614-4	2004	RESULTS: The introduction of a point mutation at position 517, substituting glutamic acid with proline, markedly reduced the binding of disease-associated GAD65 antibodies.	Proline	95-102	glutamate decarboxylase 2	Homo sapiens	155-160
15307194-2	2004	Multiple molecular weight isoforms of membrane bound CD46 are produced by alternative splicing of the CD46 mRNA in an area coding for the serine/threonine/proline-rich region or for the cytoplasmic tail.	Proline	155-162	CD46 molecule	Homo sapiens	53-57
15307194-2	2004	Multiple molecular weight isoforms of membrane bound CD46 are produced by alternative splicing of the CD46 mRNA in an area coding for the serine/threonine/proline-rich region or for the cytoplasmic tail.	Proline	155-162	CD46 molecule	Homo sapiens	102-106
15337432-1	2004	Proline analogue of melphalan (Mel-pro) is one of the pro-drugs activated by prolidase, cytoplasmic imidodipeptidase highly expressed in some neoplastic tissues.	Proline	0-7	peptidase D	Homo sapiens	77-86
15318165-5	2004	Deletion from amphiphysin of its central proline-rich stretch dramatically potentiated its effect on dynamin, possibly by relieving an inhibitory intramolecular interaction.	Proline	41-48	amphiphysin	Mus musculus	14-25
15355355-11	2004	Critical amino acids in EF-hand 1 of GCAP-1 are cysteine at position 29 and proline at position 30, as changing these to glycine was sufficient to cause loss of target activation without a loss of Ca2+-induced conformational changes.	Proline	76-83	guanylate cyclase activator 1A	Homo sapiens	37-43
15337510-2	2004	The compounds, known collectively as angiotensin-converting enzyme (ACE) inhibitors, all share the amino acid residue proline or some variant thereof, as a common structural element.	Proline	118-125	angiotensin I converting enzyme	Homo sapiens	68-71
15304101-2	2004	A new mutation of the uroporphyrinogen III synthase (UROS) gene was evidenced by systematic sequencing of the UROS gene: the substitution of serine by proline at the amino acid residue 47 (S47P) was present at the homozygous state in the four patients.	Proline	151-158	uroporphyrinogen III synthase	Homo sapiens	22-51
15356014-1	2004	A mutation in the peroxisome proliferator-activated receptor gamma2 (PPARgamma2) gene with a cytosine to guanine substitution results in an exchange of proline (Pro) with alanine (Ala) in exon B (codon 12) of this gene.	Proline	152-159	peroxisome proliferator activated receptor gamma	Homo sapiens	18-67
15356014-1	2004	A mutation in the peroxisome proliferator-activated receptor gamma2 (PPARgamma2) gene with a cytosine to guanine substitution results in an exchange of proline (Pro) with alanine (Ala) in exon B (codon 12) of this gene.	Proline	152-159	peroxisome proliferator activated receptor gamma	Homo sapiens	69-79
15356014-1	2004	A mutation in the peroxisome proliferator-activated receptor gamma2 (PPARgamma2) gene with a cytosine to guanine substitution results in an exchange of proline (Pro) with alanine (Ala) in exon B (codon 12) of this gene.	Proline	161-164	peroxisome proliferator activated receptor gamma	Homo sapiens	18-67
15356014-1	2004	A mutation in the peroxisome proliferator-activated receptor gamma2 (PPARgamma2) gene with a cytosine to guanine substitution results in an exchange of proline (Pro) with alanine (Ala) in exon B (codon 12) of this gene.	Proline	161-164	peroxisome proliferator activated receptor gamma	Homo sapiens	69-79
15304101-2	2004	A new mutation of the uroporphyrinogen III synthase (UROS) gene was evidenced by systematic sequencing of the UROS gene: the substitution of serine by proline at the amino acid residue 47 (S47P) was present at the homozygous state in the four patients.	Proline	151-158	uroporphyrinogen III synthase	Homo sapiens	53-57
15304101-2	2004	A new mutation of the uroporphyrinogen III synthase (UROS) gene was evidenced by systematic sequencing of the UROS gene: the substitution of serine by proline at the amino acid residue 47 (S47P) was present at the homozygous state in the four patients.	Proline	151-158	uroporphyrinogen III synthase	Homo sapiens	110-114
15308737-2	2004	EBNA 3C contains glutamine-rich and proline-rich domains and a region in the N terminus consisting of a stretch of basic residues followed by a run of leucine residues spaced seven amino acids apart.	Proline	36-43	EBNA-3C	Human gammaherpesvirus 4	0-7
15362101-3	2004	In contrast, proline suppresses these processes, probably, due to its specific interaction with PhK.	Proline	13-20	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	96-99
15363066-1	2004	The trembler-j mouse is a spontaneously occurring, demyelinating mutant secondary to a point mutation involving a leucine for proline substitution in the first transmembrane domain of the peripheral-myelin protein-22 (PMP-22) gene.	Proline	126-133	peripheral myelin protein 22	Mus musculus	188-216
15363066-1	2004	The trembler-j mouse is a spontaneously occurring, demyelinating mutant secondary to a point mutation involving a leucine for proline substitution in the first transmembrane domain of the peripheral-myelin protein-22 (PMP-22) gene.	Proline	126-133	peripheral myelin protein 22	Mus musculus	218-224
15308737-9	2004	Disruption of the helical nature of the zipper domain by the introduction of proline residues reduces the ability of EBNA 3C to inhibit EBNA 2 activation and interact with RBP-Jkappa in vivo by 50%, and perturbation of the charge on the basic region completely abolishes this function of EBNA 3C.	Proline	77-84	EBNA-3C	Human gammaherpesvirus 4	117-124
15308737-9	2004	Disruption of the helical nature of the zipper domain by the introduction of proline residues reduces the ability of EBNA 3C to inhibit EBNA 2 activation and interact with RBP-Jkappa in vivo by 50%, and perturbation of the charge on the basic region completely abolishes this function of EBNA 3C.	Proline	77-84	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	172-182
15548361-0	2004	Selective loss of codon 72 proline p53 and frequent mutational inactivation of the retained arginine allele in colorectal cancer.	Proline	27-34	tumor protein p53	Homo sapiens	35-38
15273281-3	2004	In this context, the proline form of TP53 codon 72 polymorphism has been recently associated with the risk of developing endometriosis.	Proline	21-28	tumor protein p53	Homo sapiens	37-41
15278437-3	2004	This mutation introduces an extra proline residue at position 279 in the Scd1 protein.	Proline	34-41	stearoyl-Coenzyme A desaturase 1	Mus musculus	73-77
15314150-3	2004	Here we have investigated Ras-induced phosphorylation of C/EBPbeta in fibroblasts and report a novel proline-directed phosphoacceptor site at Ser64 within the transactivation domain.	Proline	101-108	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	57-66
15248095-6	2004	Using a bioinformatics approach, we found that the highly conserved S44 is predicted to be phosphorylated by a number of family members of the proline-directed serine/threonine cyclin-dependent kinases (Cdks).	Proline	143-150	cyclin dependent kinase 1	Homo sapiens	203-207
15548361-1	2004	According to recent reports, some cancer types exhibit nonrandom allele loss at codon 72 in exon 4 of the p53 gene [coding for proline (72Pro) or arginine (72Arg)].	Proline	127-134	tumor protein p53	Homo sapiens	106-109
15318035-4	2004	The aim of this study is to examine whether a potentially functional polymorphism, a proline (Pro) to leucine (Leu) substitution at codon 197 (Pro197Leu) of the human GPX1 gene, is associated with susceptibility to schizophrenia.	Proline	85-92	glutathione peroxidase 1	Homo sapiens	167-171
15318035-4	2004	The aim of this study is to examine whether a potentially functional polymorphism, a proline (Pro) to leucine (Leu) substitution at codon 197 (Pro197Leu) of the human GPX1 gene, is associated with susceptibility to schizophrenia.	Proline	94-97	glutathione peroxidase 1	Homo sapiens	167-171
15317977-8	2004	The gld-2 C-to-U editing event changes the codon from CCG to CUG, which is predicted to cause a proline to leucine substitution in the protein sequence.	Proline	96-103	PAP-associated domain-containing protein;Poly(A) RNA polymerase gld-2	Caenorhabditis elegans	4-9
15493147-10	2004	The 64th amino acid of giant panda prolactin is hydrophilic serine instead of hydrophobic proline of cat, goat, and cow or hydrophobic alanine of human.	Proline	90-97	prolactin	Ailuropoda melanoleuca	35-44
15341735-0	2004	The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma.	Proline	47-54	CYLD lysine 63 deubiquitinase	Homo sapiens	22-26
15341735-0	2004	The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma.	Proline	47-54	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	72-76
15341735-0	2004	The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma.	Proline	47-54	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	77-85
15341735-4	2004	Here we report that the third CAP-Gly domain of CYLD specifically interacts with one of the two proline-rich sequences of NEMO/IKKgamma.	Proline	96-103	CYLD lysine 63 deubiquitinase	Homo sapiens	48-52
15341735-4	2004	Here we report that the third CAP-Gly domain of CYLD specifically interacts with one of the two proline-rich sequences of NEMO/IKKgamma.	Proline	96-103	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	122-126
15341735-4	2004	Here we report that the third CAP-Gly domain of CYLD specifically interacts with one of the two proline-rich sequences of NEMO/IKKgamma.	Proline	96-103	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	127-135
15208323-9	2004	Therefore, despite having previously identified Arg-4, Pro-5, Leu-8, and Leu-10 in TI-JIP as independently critical for mediating JNK inhibition, we find their presence in other 11-mer peptides is not sufficient for JNK inhibition.	Proline	55-58	SMAD family member 4	Homo sapiens	86-89
15323500-8	2004	These masses are tentatively attributed to desorption of HCN, ethylene, and/or acetylene as they represent the logical further decomposition of the different fragments of proline.	Proline	171-178	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	57-60
15257284-2	2004	The conformation and function of phosphorylated Ser/Thr-Pro motifs are further regulated by the prolyl isomerase Pin1.	Proline	56-59	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	113-117
15308773-0	2004	Role of the yeast acetyltransferase Mpr1 in oxidative stress: regulation of oxygen reactive species caused by a toxic proline catabolism intermediate.	Proline	118-125	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	36-40
15308773-1	2004	The MPR1 gene, which is found in the Sigma1278b strain but is not present in the sequenced laboratory strain S288C, of the budding yeast Saccharomyces cerevisiae encodes a previously uncharacterized N-acetyltransferase that detoxifies the proline analogue azetidine-2-carboxylate (AZC).	Proline	239-246	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	4-8
15308773-1	2004	The MPR1 gene, which is found in the Sigma1278b strain but is not present in the sequenced laboratory strain S288C, of the budding yeast Saccharomyces cerevisiae encodes a previously uncharacterized N-acetyltransferase that detoxifies the proline analogue azetidine-2-carboxylate (AZC).	Proline	239-246	N-acetyltransferase	Saccharomyces cerevisiae S288C	199-218
15229225-7	2004	A PEST motif (rich in proline, glutamine, serine, and threonine) located in the carboxyl terminus of NPDC-1 was shown to target the protein for degradation.	Proline	22-29	neural proliferation, differentiation and control 1	Homo sapiens	101-107
15235584-2	2004	In this work, we screened human cDNAs that can rescue yeast Saccharomyces cerevisiae from lethality caused by ectopic expression of human cyclin E and isolated a cDNA encoding ESXR1, a paired-like homeodomain-containing protein with a unique C-terminal proline-rich repeat region.	Proline	253-260	ESX homeobox 1	Homo sapiens	176-181
15235584-7	2004	The C-terminal fragment, containing a proline-rich repeat region, is localized to the cytoplasm and displays the ability to inhibit cyclin degradation.	Proline	38-45	proliferating cell nuclear antigen	Homo sapiens	132-138
15358169-2	2004	Proline substitution of single residues in the P16-P20 region (situated at the proximal hinge of the reactive site loop) of wild-type PAI-1 (wtPAI-1) and a stabilized PAI-1-variant (PAI-1-stab; N150H, K154T, Q301P, Q319L, and M354I, t(1/2)=150), respectively, resulted in two series of PAI-1-variants with different properties.	Proline	0-7	tubulin polymerization promoting protein family member 3	Homo sapiens	51-54
15358169-2	2004	Proline substitution of single residues in the P16-P20 region (situated at the proximal hinge of the reactive site loop) of wild-type PAI-1 (wtPAI-1) and a stabilized PAI-1-variant (PAI-1-stab; N150H, K154T, Q301P, Q319L, and M354I, t(1/2)=150), respectively, resulted in two series of PAI-1-variants with different properties.	Proline	0-7	serpin family E member 1	Homo sapiens	134-139
15358169-2	2004	Proline substitution of single residues in the P16-P20 region (situated at the proximal hinge of the reactive site loop) of wild-type PAI-1 (wtPAI-1) and a stabilized PAI-1-variant (PAI-1-stab; N150H, K154T, Q301P, Q319L, and M354I, t(1/2)=150), respectively, resulted in two series of PAI-1-variants with different properties.	Proline	0-7	serpin family E member 1	Homo sapiens	143-148
15358169-2	2004	Proline substitution of single residues in the P16-P20 region (situated at the proximal hinge of the reactive site loop) of wild-type PAI-1 (wtPAI-1) and a stabilized PAI-1-variant (PAI-1-stab; N150H, K154T, Q301P, Q319L, and M354I, t(1/2)=150), respectively, resulted in two series of PAI-1-variants with different properties.	Proline	0-7	serpin family E member 1	Homo sapiens	143-148
15358169-2	2004	Proline substitution of single residues in the P16-P20 region (situated at the proximal hinge of the reactive site loop) of wild-type PAI-1 (wtPAI-1) and a stabilized PAI-1-variant (PAI-1-stab; N150H, K154T, Q301P, Q319L, and M354I, t(1/2)=150), respectively, resulted in two series of PAI-1-variants with different properties.	Proline	0-7	serpin family E member 1	Homo sapiens	143-148
15307755-2	2004	A chiral group at C-4 of the acid chloride of proline directs the stereoselectivity of Staudinger chemistry and later is sacrificed to obtain optically active 5.4-spiro-beta-lactams.	Proline	46-53	complement C4A (Rodgers blood group)	Homo sapiens	18-21
15301538-4	2004	The SH3-binding site in murine PrP was thus found to be in the highly conserved region of residues 100-109, which contains prolines in positions 101 and 104.	Proline	123-131	prion protein	Mus musculus	31-34
15265726-1	2004	Proline-containing peptides of the X-proline type are cleaved by the dipeptidase prolidase.	Proline	0-7	peptidase D	Homo sapiens	81-90
15265726-2	2004	The classical method of prolidase assay relied on the colorimetric estimation of the liberated proline with ninhydrin using acidic media and heat.	Proline	95-102	peptidase D	Homo sapiens	24-33
15187083-3	2004	The PRH homeodomain represses transcription by binding to TATA box sequences, whereas the proline-rich N-terminal domain of PRH can repress transcription when attached to a heterologous DNA-binding domain.	Proline	90-97	hematopoietically expressed homeobox	Homo sapiens	124-127
15313924-1	2004	The antiangiogenic activity of the multidomain plasma protein histidine-proline-rich glycoprotein (HPRG) is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells (X. Guan et al., Thromb Haemost, in press).	Proline	72-79	histidine-rich glycoprotein	Mus musculus	99-103
15313924-1	2004	The antiangiogenic activity of the multidomain plasma protein histidine-proline-rich glycoprotein (HPRG) is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells (X. Guan et al., Thromb Haemost, in press).	Proline	72-79	fibroblast growth factor 2	Mus musculus	272-298
15100151-2	2004	TLT-1 (TREM-like transcript-1) lies within the TREM gene cluster and contains the characteristic single V-set immunoglobulin (Ig) domain of the family, but its longer cytoplasmic tail is composed of both a proline-rich region and an immune receptor tyrosine-based inhibitory motif, the latter known to be used for interactions with protein tyrosine phosphatases.	Proline	206-213	triggering receptor expressed on myeloid cells like 1	Homo sapiens	0-5
15100151-2	2004	TLT-1 (TREM-like transcript-1) lies within the TREM gene cluster and contains the characteristic single V-set immunoglobulin (Ig) domain of the family, but its longer cytoplasmic tail is composed of both a proline-rich region and an immune receptor tyrosine-based inhibitory motif, the latter known to be used for interactions with protein tyrosine phosphatases.	Proline	206-213	triggering receptor expressed on myeloid cells like 1	Homo sapiens	7-29
15187083-5	2004	Here we demonstrate that the proline-rich N-terminal domain of PRH binds to TLE1 in vitro and in yeast two-hybrid assays.	Proline	29-36	hematopoietically expressed homeobox	Homo sapiens	63-66
15229879-9	2004	The results show that CA(N) residues His87-Ala-Gly-Pro-Ile-Ala92 form the majority of the interactions with CypA residues.	Proline	51-54	peptidylprolyl isomerase A	Homo sapiens	108-112
15199065-13	2004	Pro to Gln mutations in the first LP dipeptide in the putative FKBP binding domain eliminated FKBP12 and FKBP52 interaction with TRPC3 and -C6, and TRPC1 and -C4, respectively.	Proline	0-3	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	94-100
15199065-13	2004	Pro to Gln mutations in the first LP dipeptide in the putative FKBP binding domain eliminated FKBP12 and FKBP52 interaction with TRPC3 and -C6, and TRPC1 and -C4, respectively.	Proline	0-3	FKBP prolyl isomerase 4	Homo sapiens	105-111
15199065-13	2004	Pro to Gln mutations in the first LP dipeptide in the putative FKBP binding domain eliminated FKBP12 and FKBP52 interaction with TRPC3 and -C6, and TRPC1 and -C4, respectively.	Proline	0-3	transient receptor potential cation channel subfamily C member 3	Homo sapiens	129-134
15199065-13	2004	Pro to Gln mutations in the first LP dipeptide in the putative FKBP binding domain eliminated FKBP12 and FKBP52 interaction with TRPC3 and -C6, and TRPC1 and -C4, respectively.	Proline	0-3	transient receptor potential cation channel subfamily C member 1	Homo sapiens	148-153
15187083-5	2004	Here we demonstrate that the proline-rich N-terminal domain of PRH binds to TLE1 in vitro and in yeast two-hybrid assays.	Proline	29-36	TLE family member 1, transcriptional corepressor	Homo sapiens	76-80
15288886-6	2004	Cyclic strain stimulated the expression of system A amino acid transporter 2 mRNA in a time-dependent fashion that paralleled the increase in L-proline transport.	Proline	142-151	solute carrier family 38, member 2	Rattus norvegicus	43-76
15205465-5	2004	Of two potential caspase consensus motifs in HDAC4, both lying within a region containing proline-, glutamic acid-, serine-, and threonine-rich (PEST) sequences, we identified, by site-directed mutagenesis, Asp-289 as the prime cleavage site.	Proline	90-97	histone deacetylase 4	Homo sapiens	45-50
15208781-4	2004	We show that the risk allele, which is present in approximately 17% of white individuals from the general population and in approximately 28% of white individuals with RA, disrupts the P1 proline-rich motif that is important for interaction with Csk, potentially altering these proteins" normal function as negative regulators of T-cell activation.	Proline	188-195	C-terminal Src kinase	Homo sapiens	246-249
15287745-1	2004	Mnb/Dyrk1A is a proline-directed serine/threonine kinase implicated in Down"s syndrome.	Proline	16-23	dual specificity tyrosine phosphorylation regulated kinase 1A	Rattus norvegicus	4-10
15288886-8	2004	Moreover, conditioned media from SMCs exposed to cyclic strain stimulated the transport of L-proline in control, static SMCs and this was significantly attenuated by a transforming growth factor-beta1 neutralizing antibody.	Proline	91-100	transforming growth factor, beta 1	Rattus norvegicus	168-200
15288886-9	2004	CONCLUSIONS: These results demonstrate that cyclic strain stimulates L-proline transport by inducing system A amino acid transporter 2 gene expression through the autocrine release of transforming growth factor-beta1.	Proline	69-78	solute carrier family 38, member 2	Rattus norvegicus	101-134
15288886-9	2004	CONCLUSIONS: These results demonstrate that cyclic strain stimulates L-proline transport by inducing system A amino acid transporter 2 gene expression through the autocrine release of transforming growth factor-beta1.	Proline	69-78	transforming growth factor, beta 1	Rattus norvegicus	184-216
15288886-10	2004	The ability of cyclic strain to induce system A amino acid transporter 2 expression may promote arterial remodeling in hypertension by providing vascular SMCs with the necessary intracellular levels of L-proline required for collagen synthesis and cell growth.	Proline	202-211	solute carrier family 38, member 2	Rattus norvegicus	39-72
15308100-0	2004	Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk.	Proline	66-73	peptidylprolyl isomerase A	Mus musculus	0-13
15104534-2	2004	In normoxia, HIF-1alpha is destabilized by post-translational hydroxylation of Pro-564 and Pro-402 by a family of oxygen-sensitive dioxygenases.	Proline	79-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
15289329-4	2004	We confirm the IRSp53/Eps8 complex formation in vivo and the direct association between Eps8 NH(2)-terminal proline-rich sequence and IRSp53 SH3 domain.	Proline	108-115	epidermal growth factor receptor pathway substrate 8	Homo sapiens	88-92
15289329-4	2004	We confirm the IRSp53/Eps8 complex formation in vivo and the direct association between Eps8 NH(2)-terminal proline-rich sequence and IRSp53 SH3 domain.	Proline	108-115	BAR/IMD domain containing adaptor protein 2	Homo sapiens	134-140
15242778-3	2004	Tests with deletion mutants of SOCS-7 demonstrated that a central region of the molecule containing several proline-rich regions, N-terminal to the SH2 domain, was responsible for the binding to vinexin.	Proline	108-115	suppressor of cytokine signaling 7	Homo sapiens	31-37
15242778-3	2004	Tests with deletion mutants of SOCS-7 demonstrated that a central region of the molecule containing several proline-rich regions, N-terminal to the SH2 domain, was responsible for the binding to vinexin.	Proline	108-115	sorbin and SH3 domain containing 3	Homo sapiens	195-202
15289338-9	2004	Expression of BCR/ABL genes with deletions of either the COOH-terminal actin binding or proline-rich domains resulted in enhanced adhesion and chemotaxis compared with wild-type BCR/ABL but did not affect progenitor proliferation.	Proline	88-95	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	14-21
15114370-2	2004	The C-terminal part of CEL consists of a unique structure with proline-rich O-glycosylated repeats of 11 amino-acid residues each.	Proline	63-70	carboxyl ester lipase	Homo sapiens	23-26
15114370-3	2004	The common variant of the human CEL gene contains 16 proline-rich repeats, but there is a high degree of polymorphism in the repeated region.	Proline	53-60	carboxyl ester lipase	Homo sapiens	32-35
15308100-0	2004	Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk.	Proline	66-73	T cell receptor alpha variable 6-3	Mus musculus	24-27
15308100-0	2004	Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk.	Proline	66-73	IL2 inducible T cell kinase	Mus musculus	108-111
15308100-7	2004	Mutation of a conformationally heterogeneous proline in the SH2 domain of Itk disrupted interaction with CypA and specifically increased Th2 cytokine production from wild-type CD4+ T cells.	Proline	45-52	IL2 inducible T cell kinase	Mus musculus	74-77
15308100-7	2004	Mutation of a conformationally heterogeneous proline in the SH2 domain of Itk disrupted interaction with CypA and specifically increased Th2 cytokine production from wild-type CD4+ T cells.	Proline	45-52	peptidylprolyl isomerase A	Mus musculus	105-109
15308100-7	2004	Mutation of a conformationally heterogeneous proline in the SH2 domain of Itk disrupted interaction with CypA and specifically increased Th2 cytokine production from wild-type CD4+ T cells.	Proline	45-52	heart and neural crest derivatives expressed 2	Mus musculus	137-140
15254753-14	2004	Human HES family proteins were found consisting of bHLH, Orange, Proline-rich domains, and WRPW motif.	Proline	65-72	hes family bHLH transcription factor 1	Homo sapiens	6-9
15308100-8	2004	Thus, CypA inhibits CD4+ T cell signal transduction in the absence of cyclosporine via a regulatory proline residue in Itk.	Proline	100-107	peptidylprolyl isomerase A	Mus musculus	6-10
15308100-8	2004	Thus, CypA inhibits CD4+ T cell signal transduction in the absence of cyclosporine via a regulatory proline residue in Itk.	Proline	100-107	IL2 inducible T cell kinase	Mus musculus	119-122
15285728-9	2004	This study describes a novel high incidence antigen (SERF) in the Cromer blood group system characterized by the amino acid proline at position 182 in SCR3 of DAF.	Proline	124-131	CD55 molecule (Cromer blood group)	Homo sapiens	159-162
15280504-1	2004	The ORF2 gene of Gill-associated virus (GAV) of Penaeus monodon prawns resides 93 nucleotides downstream of the ORF1a-ORF1b gene and encodes a 144-amino-acid hydrophilic polypeptide (15,998 Da; pI, 9.75) containing 20 basic (14%) and 13 acidic (9%) residues and 19 prolines (13%).	Proline	265-273	hypothetical protein	Escherichia coli	4-8
15247771-3	2004	MATERIALS AND METHODS: Genotypes of the leucine (Leu) to proline (Pro) polymorphism at codon 198 of GPX1, the alanine (Ala) to Valine (Val) polymorphism in exon 2 and the isoleucine to threonine polymorphism at codon 56 of MnSOD were determined by a polymerase chain reaction-restriction fragment length polymorphism technique in 213 patients and 209 normal controls.	Proline	57-64	glutathione peroxidase 1	Homo sapiens	100-104
15247771-3	2004	MATERIALS AND METHODS: Genotypes of the leucine (Leu) to proline (Pro) polymorphism at codon 198 of GPX1, the alanine (Ala) to Valine (Val) polymorphism in exon 2 and the isoleucine to threonine polymorphism at codon 56 of MnSOD were determined by a polymerase chain reaction-restriction fragment length polymorphism technique in 213 patients and 209 normal controls.	Proline	66-69	glutathione peroxidase 1	Homo sapiens	100-104
15247771-3	2004	MATERIALS AND METHODS: Genotypes of the leucine (Leu) to proline (Pro) polymorphism at codon 198 of GPX1, the alanine (Ala) to Valine (Val) polymorphism in exon 2 and the isoleucine to threonine polymorphism at codon 56 of MnSOD were determined by a polymerase chain reaction-restriction fragment length polymorphism technique in 213 patients and 209 normal controls.	Proline	66-69	superoxide dismutase 2	Homo sapiens	223-228
15223302-6	2004	On the basis of secondary structure predictions, it was hypothesized that the amino acid motifs Pro-Ile-Gly of mUcnII and Pro-Thr-Asn of mUcnIII decrease alpha-helicity and thereby impair binding to CRF1.	Proline	96-99	corticotropin releasing hormone receptor 1	Homo sapiens	199-203
15223302-6	2004	On the basis of secondary structure predictions, it was hypothesized that the amino acid motifs Pro-Ile-Gly of mUcnII and Pro-Thr-Asn of mUcnIII decrease alpha-helicity and thereby impair binding to CRF1.	Proline	122-125	corticotropin releasing hormone receptor 1	Homo sapiens	199-203
15172637-3	2004	In this study, we constructed an expression vector expressing mutant type p27Kip1 gene (pcDNA3.1-p27Kip1 mt), with mutation of Thr-187/Pro-188 (ACGCCC) to Met-187/Ile-188 (ATGATC), which is not influenced by ubiquitin-mediated degradation.	Proline	135-138	cyclin dependent kinase inhibitor 1B	Homo sapiens	74-81
15172637-3	2004	In this study, we constructed an expression vector expressing mutant type p27Kip1 gene (pcDNA3.1-p27Kip1 mt), with mutation of Thr-187/Pro-188 (ACGCCC) to Met-187/Ile-188 (ATGATC), which is not influenced by ubiquitin-mediated degradation.	Proline	135-138	cyclin dependent kinase inhibitor 1B	Homo sapiens	97-104
15269838-1	2004	The anti-angiogenic properties of the histidine-proline-rich (H/P) domain of HPRG have recently been described (Juarez JC, et al.	Proline	48-55	histidine rich glycoprotein	Homo sapiens	77-81
15145941-0	2004	Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.	Proline	128-135	F-box protein 7	Homo sapiens	0-4
15145941-0	2004	Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.	Proline	128-135	cyclin dependent kinase 1	Homo sapiens	45-49
15246269-4	2004	Sequence analysis of the env gene of BPZm.12 revealed the substitution of a serine residue for a highly conserved proline residue at position 629 in gp41.	Proline	114-121	endogenous retrovirus group K member 20	Homo sapiens	25-28
15145941-0	2004	Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.	Proline	128-135	KIT ligand	Homo sapiens	22-25
15145941-0	2004	Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.	Proline	128-135	DLG associated protein 5	Homo sapiens	74-103
15145941-0	2004	Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.	Proline	128-135	DLG associated protein 5	Homo sapiens	105-109
15195105-5	2004	We show that conformational changes in the head, tail and proline-rich domains are linked structurally and thermodynamically, and propose a combinatorial pathway to activation that ensures that vinculin is activated only at sites of cell adhesion when two or more of its binding partners are brought into apposition.	Proline	58-65	vinculin	Homo sapiens	194-202
15145941-6	2004	In the SCF(Fbx7) complex, Fbx7 recruits HURP through its C-terminal proline-rich region in a Cdk1-cyclin B-phosphorylation dependent manner.	Proline	68-75	KIT ligand	Homo sapiens	7-10
15145941-6	2004	In the SCF(Fbx7) complex, Fbx7 recruits HURP through its C-terminal proline-rich region in a Cdk1-cyclin B-phosphorylation dependent manner.	Proline	68-75	F-box protein 7	Homo sapiens	11-15
15145941-6	2004	In the SCF(Fbx7) complex, Fbx7 recruits HURP through its C-terminal proline-rich region in a Cdk1-cyclin B-phosphorylation dependent manner.	Proline	68-75	F-box protein 7	Homo sapiens	26-30
15145941-6	2004	In the SCF(Fbx7) complex, Fbx7 recruits HURP through its C-terminal proline-rich region in a Cdk1-cyclin B-phosphorylation dependent manner.	Proline	68-75	DLG associated protein 5	Homo sapiens	40-44
15145941-6	2004	In the SCF(Fbx7) complex, Fbx7 recruits HURP through its C-terminal proline-rich region in a Cdk1-cyclin B-phosphorylation dependent manner.	Proline	68-75	cyclin dependent kinase 1	Homo sapiens	93-97
15145941-7	2004	Mutation of the multiple Cdk1-cyclin B phosphorylation sites on HURP or the proline-rich region of Fbx7 abolishes the association between Fbx7 and HURP.	Proline	76-83	F-box protein 7	Homo sapiens	99-103
15145941-7	2004	Mutation of the multiple Cdk1-cyclin B phosphorylation sites on HURP or the proline-rich region of Fbx7 abolishes the association between Fbx7 and HURP.	Proline	76-83	F-box protein 7	Homo sapiens	138-142
15145941-7	2004	Mutation of the multiple Cdk1-cyclin B phosphorylation sites on HURP or the proline-rich region of Fbx7 abolishes the association between Fbx7 and HURP.	Proline	76-83	DLG associated protein 5	Homo sapiens	147-151
15145941-8	2004	Thus, Fbx7 is a functional adaptor of the SCF complex with a proline-rich region as the substrate-binding module.	Proline	61-68	F-box protein 7	Homo sapiens	6-10
15138272-1	2004	Histidine-rich glycoprotein (HRG) is an alpha2-glycoprotein found in mammalian plasma at high concentrations (approximately 150 microg/ml) and is distinguished by its high content of histidine and proline.	Proline	197-204	histidine rich glycoprotein	Homo sapiens	0-27
15145941-8	2004	Thus, Fbx7 is a functional adaptor of the SCF complex with a proline-rich region as the substrate-binding module.	Proline	61-68	KIT ligand	Homo sapiens	42-45
15240099-3	2004	Like yeast Vps1p, it lacks pleckstrin homology domain and proline-rich region.	Proline	58-65	dynamin-like GTPase VPS1	Saccharomyces cerevisiae S288C	11-16
15138272-1	2004	Histidine-rich glycoprotein (HRG) is an alpha2-glycoprotein found in mammalian plasma at high concentrations (approximately 150 microg/ml) and is distinguished by its high content of histidine and proline.	Proline	197-204	histidine rich glycoprotein	Homo sapiens	29-32
15183530-0	2004	Proline homozygosity in codon 72 of p53 is a factor of susceptibility for thyroid cancer.	Proline	0-7	tumor protein p53	Homo sapiens	36-39
15183530-1	2004	A common germline polymorphism of p53 gene produces an Arginine to Proline change at aminoacid position 72.	Proline	67-74	tumor protein p53	Homo sapiens	34-37
15138272-2	2004	Structurally, HRG is a modular protein consisting of an N-terminal cystatin-like domain (N1N2), a central histidine-rich region (HRR) flanked by proline-rich sequences, and a C-terminal domain.	Proline	145-152	histidine rich glycoprotein	Homo sapiens	14-17
15123602-8	2004	Once PBR/AIR is released by phosphorylation, rearrangements of the SH3 domains may occur, forming an open structure that binds to the cytoplasmic proline-rich region of membrane-bound p22(phox).	Proline	146-153	translocator protein	Homo sapiens	5-8
15236580-2	2004	Here we report the high-resolution crystal structures of testis ACE (tACE) in complex with the first successfully designed ACE inhibitor captopril and enalaprilat, the Phe-Ala-Pro analogue.	Proline	176-179	angiotensin I converting enzyme	Homo sapiens	64-67
15236580-2	2004	Here we report the high-resolution crystal structures of testis ACE (tACE) in complex with the first successfully designed ACE inhibitor captopril and enalaprilat, the Phe-Ala-Pro analogue.	Proline	176-179	angiotensin I converting enzyme	Homo sapiens	70-73
15245913-1	2004	Dipeptidyl peptidase (DP) IV has a distinct substrate specificity in hydrolyzing a post-proline bond.	Proline	88-95	dipeptidyl peptidase 4	Homo sapiens	0-28
15123602-8	2004	Once PBR/AIR is released by phosphorylation, rearrangements of the SH3 domains may occur, forming an open structure that binds to the cytoplasmic proline-rich region of membrane-bound p22(phox).	Proline	146-153	dynein cytoplasmic 1 heavy chain 1	Homo sapiens	184-187
15123626-1	2004	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine protein kinase that requires association with a regulatory protein, p35 or p39, to form an active enzyme.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	0-25
15123626-1	2004	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine protein kinase that requires association with a regulatory protein, p35 or p39, to form an active enzyme.	Proline	38-45	cyclin dependent kinase 5	Homo sapiens	27-31
15105431-3	2004	Here, we investigate the sequence requirements for the CD2BP2-GYF domain, a proline-rich sequence binding module previously shown to be involved in T cell signaling.	Proline	76-83	CD2 cytoplasmic tail binding protein 2	Homo sapiens	55-61
15123626-1	2004	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine protein kinase that requires association with a regulatory protein, p35 or p39, to form an active enzyme.	Proline	38-45	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	140-143
15123626-1	2004	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine protein kinase that requires association with a regulatory protein, p35 or p39, to form an active enzyme.	Proline	38-45	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	147-150
15225881-0	2004	Conservation and expression of an alternative 3" exon of Runx2 encoding a novel proline-rich C-terminal domain.	Proline	80-87	RUNX family transcription factor 2	Homo sapiens	57-62
15225881-2	2004	While all three mammalian Runx genes share a complex dual promoter structure (P1, P2) and display alternative splicing, a distinctive feature of Runx2 is the potential to encode larger isoforms in which the C-terminal domain encoded by the standard 3" terminal exon (exon 6) is replaced by an extended 200-201 amino acid C-terminal sequence including an extensive proline-rich domain and a C-terminal amphipathic helix.	Proline	364-371	RUNX family transcription factor 2	Homo sapiens	145-150
15107419-2	2004	The self-association of NEMO involves the C-terminal halves of the polypeptide chains containing two putative coiled-coil motifs (a CC2 and a LZ leucine zipper), a proline-rich region, and a ZF zinc finger motif.	Proline	164-171	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	24-28
15123681-4	2004	IRS-2 from db/db mouse PerMPhis also showed a 78% increase in Ser/Thr-Pro motif phosphorylation without a difference in IRS-2 mass.	Proline	70-73	insulin receptor substrate 2	Mus musculus	0-5
15236666-8	2004	This new exon encodes an interesting proline-rich signature that could confer to the 34 kDa Spatial-beta protein a particular function.	Proline	37-44	thymus, brain and testes associated	Mus musculus	92-99
15123681-9	2004	When IRS-2 Ser/Thr-Pro motif phosphorylation was examined, chronic insulin + high glucose resulted in a 92% increase in IRS-2 Ser/Thr-Pro motif phosphorylation without a change in IRS-2 mass.	Proline	19-22	insulin receptor substrate 2	Homo sapiens	5-10
15123681-9	2004	When IRS-2 Ser/Thr-Pro motif phosphorylation was examined, chronic insulin + high glucose resulted in a 92% increase in IRS-2 Ser/Thr-Pro motif phosphorylation without a change in IRS-2 mass.	Proline	19-22	insulin	Homo sapiens	67-74
15123681-9	2004	When IRS-2 Ser/Thr-Pro motif phosphorylation was examined, chronic insulin + high glucose resulted in a 92% increase in IRS-2 Ser/Thr-Pro motif phosphorylation without a change in IRS-2 mass.	Proline	134-137	insulin	Homo sapiens	67-74
15123681-9	2004	When IRS-2 Ser/Thr-Pro motif phosphorylation was examined, chronic insulin + high glucose resulted in a 92% increase in IRS-2 Ser/Thr-Pro motif phosphorylation without a change in IRS-2 mass.	Proline	134-137	insulin receptor substrate 2	Homo sapiens	120-125
15123681-9	2004	When IRS-2 Ser/Thr-Pro motif phosphorylation was examined, chronic insulin + high glucose resulted in a 92% increase in IRS-2 Ser/Thr-Pro motif phosphorylation without a change in IRS-2 mass.	Proline	134-137	insulin receptor substrate 2	Homo sapiens	120-125
15236666-10	2004	We further examined the inter-species conservation of Spatial between several mammals and identified that the protein which is rich in proline and positive amino acids, is highly conserved.	Proline	135-142	thymus, brain and testes associated	Mus musculus	54-61
15059956-9	2004	Analyses using FOXL2 mutants also demonstrated the importance of the entire alanine/proline-rich carboxyl terminus of FOXL2 for transcriptional repression.	Proline	84-91	forkhead box L2	Homo sapiens	15-20
15210450-5	2004	Intra-arterial infusions of [Leu(31),Pro(34)]NPY elicited reductions (P &lt; 0.05) in vascular conductance of 38 +/- 3, 25 +/- 2, 17 +/- 1, and 11 +/- 1% at rest, 3 miles/h, 6 miles/h, and 6 miles/h and 10% grade, respectively.	Proline	37-40	neuropeptide Y	Canis lupus familiaris	45-48
15308336-4	2004	The 51-amino-acid pre-pro-peptide contains the expected hydrophobic leader sequence and the dibasic Arg-Arg sequence preceding the NH2-terminal Ser of the mature 49-amino-acid Rana osteocalcin.	Proline	22-25	bone gamma-carboxyglutamate protein	Rattus norvegicus	181-192
15059956-9	2004	Analyses using FOXL2 mutants also demonstrated the importance of the entire alanine/proline-rich carboxyl terminus of FOXL2 for transcriptional repression.	Proline	84-91	forkhead box L2	Homo sapiens	118-123
15214045-6	2004	The Src-homology 3(SH3) domain of Tec and the two proline-rich motifs of CD28 are involved in this process.	Proline	50-57	CD28 molecule	Homo sapiens	73-77
15214045-7	2004	Furthermore, we show that CD28 signaling requires the SH3 domain of Tec as well as proline residues present in the intracytoplasmic tail of CD28.	Proline	83-90	CD28 molecule	Homo sapiens	26-30
15214045-7	2004	Furthermore, we show that CD28 signaling requires the SH3 domain of Tec as well as proline residues present in the intracytoplasmic tail of CD28.	Proline	83-90	CD28 molecule	Homo sapiens	140-144
15257943-1	2004	A single nucleotide polymorphism at TP53 codon 72 means that two alleles exist: A1 (proline residue, Pro72) and A2 (arginine residue, Arg72).	Proline	84-91	tumor protein p53	Homo sapiens	36-40
15199099-4	2004	Although prolyl hydroxylation at conserved proline residues is a major factor controlling HIF-1alpha stability, the redox state of the cells may, in addition, influence the function of HIF-1alpha like proteins by influencing their stability, DNA binding and phosphorylation.	Proline	43-50	hypoxia-inducible factor 1-alpha	Oncorhynchus mykiss	90-100
15199099-6	2004	The predicted amino acid sequence of rainbow trout HIF-1alpha contains several unique cysteine residues, notably in the DNA-binding area at position 28 and in the transactivation domain of the molecule in the vicinity of the conserved proline residue at position 564 of mammalian HIF-1alpha.	Proline	235-242	hypoxia-inducible factor 1-alpha	Oncorhynchus mykiss	51-61
15353880-4	2004	DNA analysis of the alpha-Gal A gene revealed a novel missense mutation at codon 19 in exon 1, resulting in leucine-to-proline substitution.	Proline	119-126	galactosidase alpha	Homo sapiens	20-31
15064722-0	2004	WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins.	Proline	24-31	WW domain containing oxidoreductase	Homo sapiens	0-4
15213848-3	2004	DNA sequencing revealed a C to T transition in the patient"s remaining GP1BB allele, predicting a novel proline to serine substitution (Pro96Ser) in the carboxyterminal flanking domain of a leucine-rich repeat.	Proline	104-111	glycoprotein Ib platelet subunit beta	Homo sapiens	71-76
15133129-4	2004	SGEF required its proline-rich amino-terminus to generate dorsal, but not lateral, membrane ruffles and a functional SH3 domain to colocalize with filamentous actin at sites of membrane protrusion.	Proline	18-25	Rho guanine nucleotide exchange factor 26	Homo sapiens	0-4
15064722-6	2004	In this report, we identify the specific proline-rich ligand for WWOX as PPXY and show that the amino-terminal WW domain is responsible for this interaction.	Proline	41-48	WW domain containing oxidoreductase	Homo sapiens	65-69
15012588-6	2004	Our recombinant human C4.4A is extensively modified by post-translational glycosylation, which include 5-6 N-linked carbohydrates primarily located in or close to its second Ly-6/uPAR/alpha-neurotoxin module and approximately 15 O-linked carbohydrates clustered in a Ser/Thr/Pro-rich region at the C-terminus.	Proline	275-278	LY6/PLAUR domain containing 3	Homo sapiens	22-27
15189041-6	2004	Analysis of specific amino acid residues in the N-terminus and C-terminus demonstrated that the presence of a proline at position 11 and alanine at positions 35 and 39 (hCRF numbering) decreases CRF1R activity and increases CRF2R selectivity in CRF, UCN1 and sauvagine peptides.	Proline	110-117	corticotropin releasing hormone receptor 1	Homo sapiens	195-199
15096513-3	2004	hnRNP U interacts specifically with the proline-rich amino terminus of YAP, a region of YAP that is not found in the related protein TAZ.	Proline	40-47	heterogeneous nuclear ribonucleoprotein U	Homo sapiens	0-7
15096513-3	2004	hnRNP U interacts specifically with the proline-rich amino terminus of YAP, a region of YAP that is not found in the related protein TAZ.	Proline	40-47	Yes1 associated transcriptional regulator	Homo sapiens	71-74
15096513-8	2004	Because YAP is distinguished from the homologue TAZ by its proline-rich amino terminus, the YAP-hnRNP U interaction may uniquely regulate the nuclear function(s) of YAP.	Proline	59-66	Yes1 associated transcriptional regulator	Homo sapiens	8-11
15096513-8	2004	Because YAP is distinguished from the homologue TAZ by its proline-rich amino terminus, the YAP-hnRNP U interaction may uniquely regulate the nuclear function(s) of YAP.	Proline	59-66	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	48-51
15096513-8	2004	Because YAP is distinguished from the homologue TAZ by its proline-rich amino terminus, the YAP-hnRNP U interaction may uniquely regulate the nuclear function(s) of YAP.	Proline	59-66	Yes1 associated transcriptional regulator	Homo sapiens	92-95
15096513-8	2004	Because YAP is distinguished from the homologue TAZ by its proline-rich amino terminus, the YAP-hnRNP U interaction may uniquely regulate the nuclear function(s) of YAP.	Proline	59-66	heterogeneous nuclear ribonucleoprotein U	Homo sapiens	96-103
15096513-8	2004	Because YAP is distinguished from the homologue TAZ by its proline-rich amino terminus, the YAP-hnRNP U interaction may uniquely regulate the nuclear function(s) of YAP.	Proline	59-66	Yes1 associated transcriptional regulator	Homo sapiens	92-95
15040788-6	2004	The proline residue that is two residues upstream of bradykinin in rat kininogen is, in part, responsible for this pattern of hydrolysis, since the peptide Abz-GFSPFRASRVQ-EDDnp was preferentially cleaved at the Arg-Ala bond by hK1.	Proline	4-11	kininogen 1	Homo sapiens	53-63
15157109-1	2004	DNA polymerase lambda (Pollambda), a member of the X-family DNA polymerases, possesses an N-terminal BRCT domain, a proline-rich domain, and a C-terminal polymerase beta-like domain (tPollambda).	Proline	116-123	DNA polymerase lambda	Homo sapiens	0-21
15040788-6	2004	The proline residue that is two residues upstream of bradykinin in rat kininogen is, in part, responsible for this pattern of hydrolysis, since the peptide Abz-GFSPFRASRVQ-EDDnp was preferentially cleaved at the Arg-Ala bond by hK1.	Proline	4-11	keratin 1	Homo sapiens	228-231
15126119-2	2004	This gene encodes a proline-directed serine/threonine protein kinase (minibrain kinase-Mnb/Dyrk1A), which is required for the proliferation of distinct neuronal cell types during postembryonic neurogenesis.	Proline	20-27	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	87-90
15126119-2	2004	This gene encodes a proline-directed serine/threonine protein kinase (minibrain kinase-Mnb/Dyrk1A), which is required for the proliferation of distinct neuronal cell types during postembryonic neurogenesis.	Proline	20-27	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	91-97
14972029-10	2004	The study concludes that the most probable sequence motif for recognition by PC4 is KXKXXR or KXXR, where X is any amino acid other than cysteine and that it prefers proline at P3, P5 and/or P2" positions.	Proline	166-173	proprotein convertase subtilisin/kexin type 4	Mus musculus	77-80
15175240-1	2004	DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family.	Proline	146-153	hepatic leukemia factor	Mus musculus	38-41
15175240-1	2004	DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family.	Proline	146-153	hepatic leukemia factor	Mus musculus	43-66
15175240-1	2004	DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family.	Proline	146-153	thyrotroph embryonic factor	Mus musculus	73-76
15175240-1	2004	DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family.	Proline	146-153	thyrotroph embryonic factor	Mus musculus	78-105
15069079-7	2004	Stat6 uniquely fails to share a positionally conserved Stat serine phosphorylation sequence; however, known phosphoacceptor sites are proline-flanked.	Proline	134-141	signal transducer and activator of transcription 6	Homo sapiens	0-5
14984367-4	2004	These enzymes are oxygen-, iron- and 2-oxoglutarate-dependent dioxygenases that hydroxylate key proline and asparagine residues in HIFalpha subunits.	Proline	96-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-139
15084514-5	2004	Recently, we demonstrated that Leu-574 of human HIF-1alpha--10 residues downstream of Pro-564--is essential for VHL recognition.	Proline	86-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
15171797-2	2004	Pin1 isomerizes the peptide bond of specific phosphorylated serine or threonine residues preceding proline in several proteins involved in various cellular events including mitosis, transcription, differentiation and DNA damage response.	Proline	99-106	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
15217616-3	2004	Five of these contained proline-rich sequences in their FG loop that resembled class I (i.e., +xxPxxP) peptide ligands for the Src SH3 domain.	Proline	24-31	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	127-130
15217616-4	2004	The sixth clone lacked the proline-rich sequence and showed particularly high binding specificity to the Src SH3 domain among various SH3 domains tested.	Proline	27-34	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-108
15161755-4	2004	The amino acid sequence of IAPP in rats and mice is identical and differs from that in humans by substitution of proline residues in the amyloidogenic sequence so that the protein no longer forms amyloid fibrils or is cytotoxic.	Proline	113-120	islet amyloid polypeptide	Rattus norvegicus	27-31
15084514-5	2004	Recently, we demonstrated that Leu-574 of human HIF-1alpha--10 residues downstream of Pro-564--is essential for VHL recognition.	Proline	86-89	von Hippel-Lindau tumor suppressor	Homo sapiens	112-115
15084514-6	2004	We show here that the role of Leu-574 is to recruit PHD2/HPH2 for Pro-564 hydroxylation.	Proline	66-69	egl-9 family hypoxia inducible factor 1	Homo sapiens	52-56
15044386-1	2004	Mucins are large glycoproteins characterized by mucin domains that show little sequence conservation and are rich in the amino acids Ser, Thr, and Pro.	Proline	147-150	LOC100508689	Homo sapiens	48-53
15084514-6	2004	We show here that the role of Leu-574 is to recruit PHD2/HPH2 for Pro-564 hydroxylation.	Proline	66-69	egl-9 family hypoxia inducible factor 1	Homo sapiens	57-61
15084514-7	2004	An antibody specific for hydroxylated Pro-564 has been used to determine the hydroxylation status; mutation or deletion of Leu-574 results in a significant decrease in the ratio of the hydroxylated HIF-1alpha to the total amount.	Proline	38-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	198-208
15153494-3	2004	We found that the N-terminal tyrosines as well as the central proline-rich region of SLP-76 are required for participation of SLP-76 in FcepsilonRI-mediated signaling and function.	Proline	62-69	lymphocyte cytosolic protein 2	Mus musculus	85-91
15138607-11	2004	Proline-rich domain was located within the divergent region of ASXL3, but not within that of ASXL1 and ASXL2.	Proline	0-7	ASXL transcriptional regulator 3	Homo sapiens	63-68
15153494-3	2004	We found that the N-terminal tyrosines as well as the central proline-rich region of SLP-76 are required for participation of SLP-76 in FcepsilonRI-mediated signaling and function.	Proline	62-69	lymphocyte cytosolic protein 2	Mus musculus	126-132
15153494-3	2004	We found that the N-terminal tyrosines as well as the central proline-rich region of SLP-76 are required for participation of SLP-76 in FcepsilonRI-mediated signaling and function.	Proline	62-69	Fc receptor, IgE, high affinity I, alpha polypeptide	Mus musculus	136-147
15163742-3	2004	Here we demonstrate that STP-A11 interacts with signal transducer and activator of transcription 3 (Stat3) independently of Src association and that the amino-terminal short proline-rich motif of STP-A11 and the central linker region of Stat3 are necessary for their interaction.	Proline	174-181	thyroid hormone receptor interactor 10	Homo sapiens	25-28
15163742-3	2004	Here we demonstrate that STP-A11 interacts with signal transducer and activator of transcription 3 (Stat3) independently of Src association and that the amino-terminal short proline-rich motif of STP-A11 and the central linker region of Stat3 are necessary for their interaction.	Proline	174-181	DXS435E	Homo sapiens	29-32
15163742-3	2004	Here we demonstrate that STP-A11 interacts with signal transducer and activator of transcription 3 (Stat3) independently of Src association and that the amino-terminal short proline-rich motif of STP-A11 and the central linker region of Stat3 are necessary for their interaction.	Proline	174-181	signal transducer and activator of transcription 3	Homo sapiens	48-98
15163742-3	2004	Here we demonstrate that STP-A11 interacts with signal transducer and activator of transcription 3 (Stat3) independently of Src association and that the amino-terminal short proline-rich motif of STP-A11 and the central linker region of Stat3 are necessary for their interaction.	Proline	174-181	thyroid hormone receptor interactor 10	Homo sapiens	196-199
15163742-3	2004	Here we demonstrate that STP-A11 interacts with signal transducer and activator of transcription 3 (Stat3) independently of Src association and that the amino-terminal short proline-rich motif of STP-A11 and the central linker region of Stat3 are necessary for their interaction.	Proline	174-181	signal transducer and activator of transcription 3	Homo sapiens	237-242
15187187-3	2004	The MKs are related serine/threonine kinases that respond to mitogenic and stress stimuli through proline-directed phosphorylation and activation of the kinase domain by extracellular signal-regulated kinases 1 and 2 and p38 MAPKs.	Proline	98-105	mitogen-activated protein kinase 3	Mus musculus	170-216
15173663-8	2004	This suggests that a decrease in prolidase activity may contribute to a decrease in the biosynthesis of proline-containing proteins, such as collagen and SOS.	Proline	104-111	peptidase D	Homo sapiens	33-42
15173663-2	2004	The mechanism of their action on collagen biosynthesis involves inactivation of prolidase, the enzyme that recovers proline from collagen degradation products for collagen re-synthesis.	Proline	116-123	peptidase D	Homo sapiens	80-89
15187187-3	2004	The MKs are related serine/threonine kinases that respond to mitogenic and stress stimuli through proline-directed phosphorylation and activation of the kinase domain by extracellular signal-regulated kinases 1 and 2 and p38 MAPKs.	Proline	98-105	mitogen-activated protein kinase 14	Mus musculus	221-224
15173663-8	2004	This suggests that a decrease in prolidase activity may contribute to a decrease in the biosynthesis of proline-containing proteins, such as collagen and SOS.	Proline	104-111	xylosyltransferase 2	Homo sapiens	154-157
15064355-4	2004	We recently cloned and identified BPGAP1 as a novel RhoGAP that coordinately regulates pseudopodia and cell migration via the interplay of its BNIP-2 and Cdc42GAP homology, RhoGAP, and the proline-rich domains.	Proline	189-196	Rho GTPase activating protein 8	Homo sapiens	34-40
15064355-4	2004	We recently cloned and identified BPGAP1 as a novel RhoGAP that coordinately regulates pseudopodia and cell migration via the interplay of its BNIP-2 and Cdc42GAP homology, RhoGAP, and the proline-rich domains.	Proline	189-196	Rho GTPase activating protein 1	Homo sapiens	52-58
15064355-6	2004	Progressive deletion studies confirmed that cortactin interacted directly and constitutively with the proline-rich motif 182-PPPRPPLP-189 of BPGAP1 via its Src homology 3 domain.	Proline	102-109	cortactin	Homo sapiens	44-53
15064355-6	2004	Progressive deletion studies confirmed that cortactin interacted directly and constitutively with the proline-rich motif 182-PPPRPPLP-189 of BPGAP1 via its Src homology 3 domain.	Proline	102-109	Rho GTPase activating protein 8	Homo sapiens	141-147
15192815-7	2004	A mutation of CCC--&gt;CGC was detected at codon 534 of the ABCD1 gene from patient 1, resulting in the arginine for proline substitution.	Proline	117-124	ATP binding cassette subfamily D member 1	Homo sapiens	60-65
15169891-7	2004	We propose that Erk phosphorylation liberates the SH3 domain of cortactin from intramolecular interactions with proline-rich regions, causing it to synergize with WASP and N-WASP in activating the Arp2/3 complex, and that Src phosphorylation terminates cortactin activation of N-WASP and WASP.	Proline	112-119	EPH receptor B2	Homo sapiens	16-19
15146501-9	2004	Although proline mutations frequently lead to the most severe structural deformations, a non-proline substitution (K14-R125S; 1A-10) gave rise to the largest local structural disruption that was observed.	Proline	93-100	keratin 14	Homo sapiens	115-118
15169891-7	2004	We propose that Erk phosphorylation liberates the SH3 domain of cortactin from intramolecular interactions with proline-rich regions, causing it to synergize with WASP and N-WASP in activating the Arp2/3 complex, and that Src phosphorylation terminates cortactin activation of N-WASP and WASP.	Proline	112-119	cortactin	Homo sapiens	64-73
15152096-2	2004	Replacement of Pro 85 with alanine in cellular retinoic acid binding protein I (CRABP-I) abolished the slowest refolding phase, suggesting that this phase is due to proline isomerization in the unfolded state.	Proline	165-172	cellular retinoic acid binding protein 1	Homo sapiens	38-78
15152096-2	2004	Replacement of Pro 85 with alanine in cellular retinoic acid binding protein I (CRABP-I) abolished the slowest refolding phase, suggesting that this phase is due to proline isomerization in the unfolded state.	Proline	165-172	cellular retinoic acid binding protein 1	Homo sapiens	80-87
15147195-1	2004	The prolyl isomerase cyclophilin A (CypA) is required for efficient HIV-1 replication and is incorporated into virions through a binding interaction at the Gly-Pro(222) bond located within the capsid domain of the HIV-1 Gag precursor polyprotein (Pr(gag)).	Proline	160-163	peptidylprolyl isomerase A	Homo sapiens	36-40
15039439-5	2004	Binding to TB2 was ablated by the presence of N-terminal domains (encoded by exons 1-8) and reduced after deleting the proline-rich region.	Proline	119-126	receptor accessory protein 5	Homo sapiens	11-14
15147195-3	2004	To address the proposal that CypA interacts with Gly-Pro sequences in the C-terminal domain of a mature capsid, the interaction between CypA and the natively folded, full-length capsid protein (CA(FL)) has been investigated here using nuclear magnetic resonance spectroscopy.	Proline	53-56	peptidylprolyl isomerase A	Homo sapiens	29-33
15147912-6	2004	Protein binding and expression studies indicated that the second SH3 domain of CIN85 binds to a proline-rich region of CAMGAP1.	Proline	96-103	SH3-domain kinase binding protein 1	Mus musculus	79-84
15134452-5	2004	TMX-3 has two important structural features: a proline residue in the hydrophobic core that discourages the formation of highly helical aggregates in solution and two histidine residues that allow control of membrane and solution interactions by means of pH changes.	Proline	47-54	thioredoxin related transmembrane protein 3	Homo sapiens	0-5
15007077-11	2004	The structure also implies that a Src homology domain 3 may interact with the left-handed proline-rich helix at the dimer interface and regulate LTB(4) 12-HD/PGR activity by disruption of the substrate binding pore to accommodate the omega-chain.	Proline	90-97	progesterone receptor	Homo sapiens	158-161
15128933-6	2004	The inherited mutation caused the substitution of a proline for an evolutionarily conserved leucine at amino acid 99 in the CYP2R1 protein and eliminated vitamin D 25-hydroxylase enzyme activity.	Proline	52-59	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	124-130
15111319-2	2004	Interestingly, the pSer/Thr-Pro motifs in proteins exist in two distinct cis and trans conformations, whose conversion rate is normally reduced on phosphorylation, but is catalyzed specifically by the prolyl isomerase Pin1.	Proline	28-31	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	218-222
15128933-6	2004	The inherited mutation caused the substitution of a proline for an evolutionarily conserved leucine at amino acid 99 in the CYP2R1 protein and eliminated vitamin D 25-hydroxylase enzyme activity.	Proline	52-59	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	154-178
15141214-4	2004	The junction is formed by three localized interactions between AQP0 molecules in adjoining membranes, mainly mediated by proline residues conserved in AQP0s from different species but not present in most other aquaporins.	Proline	121-128	major intrinsic protein of lens fiber	Homo sapiens	63-67
15141214-4	2004	The junction is formed by three localized interactions between AQP0 molecules in adjoining membranes, mainly mediated by proline residues conserved in AQP0s from different species but not present in most other aquaporins.	Proline	121-128	major intrinsic protein of lens fiber	Homo sapiens	151-155
15105048-3	2004	The p53 gene displays a common genetic Arg/Pro polymorphism at codon 72 with functional significance, that has been investigated as risk factor in several cancer models.	Proline	43-46	tumor protein p53	Homo sapiens	4-7
14996833-2	2004	Using a panel of PDGF beta-receptor mutants with progressive C-terminal truncations, we observed that deletion of the last 46 residues, which contain a proline- and glutamic acid-rich motif, increased the autoactivation velocity in vitro and the V(max) of the phosphotransfer reaction, in the absence of ligand, as compared with wild-type receptors.	Proline	152-159	platelet derived growth factor subunit B	Homo sapiens	17-26
14983521-1	2004	Palladin is an actin-associated protein that contains proline-rich motifs within its amino-terminal sequence that are similar to motifs found in zyxin, vinculin, and the Listeria protein ActA.	Proline	54-61	palladin, cytoskeletal associated protein	Homo sapiens	0-8
14983521-5	2004	Using a synthetic peptide array, two discrete binding sites for VASP were identified within palladin"s proline-rich amino-terminal domain.	Proline	103-110	vasodilator stimulated phosphoprotein	Homo sapiens	64-68
14983521-5	2004	Using a synthetic peptide array, two discrete binding sites for VASP were identified within palladin"s proline-rich amino-terminal domain.	Proline	103-110	palladin, cytoskeletal associated protein	Homo sapiens	92-100
15099969-2	2004	In this regard, genetic polymorphism at codon 72 (CCC/proline to CGC/arginine [Pro(72)Arg]) of the p53 gene is one of the most frequently studied subjects.	Proline	54-61	tumor protein p53	Homo sapiens	99-102
15006639-8	2004	Proline betaine and trigonelline appeared to be poor BHMT substrates, being largely excreted in the urine unchanged, yet increased circulating homocysteine levels.	Proline	0-7	betaine-homocysteine S-methyltransferase	Rattus norvegicus	53-57
15100295-5	2004	Inhibition of CatE expression is specific to the type III CIITA isoform and maps to the acidic and proline/serine/threonine-rich (PST) protein domains of CIITA.	Proline	99-106	cathepsin E	Homo sapiens	14-18
15216398-9	2004	The frequency of pro/pro, pro/arg, and arg/arg in p53 codon 72 in cases was 15% (15/99), 58% (57/99), and 27% (27/99) and in controls was 17% (34/193), 48% (92/193), and 35% (67/193), respectively, which was not significantly different.	Proline	17-20	tumor protein p53	Homo sapiens	50-53
15100285-0	2004	A proline-rich motif in the C terminus of Akt contributes to its localization in the immunological synapse.	Proline	2-9	thymoma viral proto-oncogene 1	Mus musculus	42-45
15100285-3	2004	A recently described proline-rich motif in this region appears to be important for proper localization of full-length Akt.	Proline	21-28	thymoma viral proto-oncogene 1	Mus musculus	118-121
15216398-9	2004	The frequency of pro/pro, pro/arg, and arg/arg in p53 codon 72 in cases was 15% (15/99), 58% (57/99), and 27% (27/99) and in controls was 17% (34/193), 48% (92/193), and 35% (67/193), respectively, which was not significantly different.	Proline	21-24	tumor protein p53	Homo sapiens	50-53
15216398-9	2004	The frequency of pro/pro, pro/arg, and arg/arg in p53 codon 72 in cases was 15% (15/99), 58% (57/99), and 27% (27/99) and in controls was 17% (34/193), 48% (92/193), and 35% (67/193), respectively, which was not significantly different.	Proline	21-24	tumor protein p53	Homo sapiens	50-53
15100295-5	2004	Inhibition of CatE expression is specific to the type III CIITA isoform and maps to the acidic and proline/serine/threonine-rich (PST) protein domains of CIITA.	Proline	99-106	class II major histocompatibility complex transactivator	Homo sapiens	154-159
15228085-5	2004	The functional implications of phosphorylation of this residue, which belongs to a serine-proline motif, are discussed in terms of the role of filamin in cytoskeleton reorganization.	Proline	90-97	filamin C	Homo sapiens	143-150
15133116-6	2004	The ilv2 mutants were auxotrophic for isoleucine and valine and the auxotrophy was satisfied by these amino acids only when proline, and not ammonium, was the nitrogen source, indicating nitrogen regulation of amino acid transport.	Proline	124-131	acetolactate synthase catalytic subunit	Saccharomyces cerevisiae S288C	4-8
15094065-1	2004	The three genes hTAF(II)68, EWS, and TLS (called the TET family) encode related RNA binding proteins containing an RNA recognition motif and three glycine-, arginine-, and proline-rich regions in the C-terminus and a degenerated repeat containing the consensus sequence Ser-Tyr-Gly-Gln-Ser in the N-terminus.	Proline	172-179	TATA-box binding protein associated factor 15	Homo sapiens	16-26
14764913-10	2004	The transition changes a serine residue into a proline, in a highly conserved region of the NADH dehydrogenase subunit 3 (ND3).	Proline	47-54	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	92-120
14764913-10	2004	The transition changes a serine residue into a proline, in a highly conserved region of the NADH dehydrogenase subunit 3 (ND3).	Proline	47-54	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	122-125
15039077-2	2004	DPP8 catalyzes the cleavage at the carboxyl side of the proline residue at the penultimate position.	Proline	56-63	dipeptidyl peptidase 8	Homo sapiens	0-4
14970238-3	2004	When cells are transferred from a good to a poor nitrogen source (glutamine to proline) or treated with rapamycin, an inhibitor of the protein kinases Tor1/2, Gln3 (NCR-sensitive transcription activator) moves from the cytoplasm into the nucleus.	Proline	79-86	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	151-157
14970238-8	2004	Latrunculin-treatment prevents nuclear accumulation of Gln3 and NCR-sensitive transcription in cells transferred from ammonia to proline medium but does not prevent its accumulation in the cytoplasm of cells transferred from proline to glutamine medium.	Proline	129-136	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	55-59
15069555-2	2004	The p53 codon 72 Arg right curved arrow Pro polymorphism has been suggested to be associated with risk for different kind of cancers, but the data on gastric cancer (GC) is very limited.	Proline	40-43	tumor protein p53	Homo sapiens	4-7
15077186-1	2004	A single-nucleotide polymorphism (SNP) in exon 4 results in expression of either arginine (72R) or proline (72P) at codon 72 of p53.	Proline	99-106	tumor protein p53	Homo sapiens	128-131
15094065-1	2004	The three genes hTAF(II)68, EWS, and TLS (called the TET family) encode related RNA binding proteins containing an RNA recognition motif and three glycine-, arginine-, and proline-rich regions in the C-terminus and a degenerated repeat containing the consensus sequence Ser-Tyr-Gly-Gln-Ser in the N-terminus.	Proline	172-179	EWS RNA binding protein 1	Homo sapiens	28-31
15094065-1	2004	The three genes hTAF(II)68, EWS, and TLS (called the TET family) encode related RNA binding proteins containing an RNA recognition motif and three glycine-, arginine-, and proline-rich regions in the C-terminus and a degenerated repeat containing the consensus sequence Ser-Tyr-Gly-Gln-Ser in the N-terminus.	Proline	172-179	FUS RNA binding protein	Homo sapiens	37-40
14722089-0	2004	Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function.	Proline	13-20	lymphocyte cytosolic protein 2	Homo sapiens	36-42
15083196-1	2004	Human endostatin has an internal Asn-Gly-Arg (NGR) motif at position 126-128 following a proline at position 125.	Proline	89-96	collagen type XVIII alpha 1 chain	Homo sapiens	6-16
15083196-3	2004	We previously compared the in vitro and in vivo biological activities of native endostatin and endostatin with a proline to alanine mutation (P125A-endostatin).	Proline	113-120	collagen type XVIII alpha 1 chain	Homo sapiens	95-105
15083196-3	2004	We previously compared the in vitro and in vivo biological activities of native endostatin and endostatin with a proline to alanine mutation (P125A-endostatin).	Proline	113-120	collagen type XVIII alpha 1 chain	Homo sapiens	95-105
14761940-6	2004	The interaction between Rsp5 and Rvs167 is mediated through Rsp5 WW domains and PXY motifs in the central Gly-Pro-Ala-rich domain of Rvs167.	Proline	110-113	amphiphysin	Saccharomyces cerevisiae S288C	133-139
14761940-6	2004	The interaction between Rsp5 and Rvs167 is mediated through Rsp5 WW domains and PXY motifs in the central Gly-Pro-Ala-rich domain of Rvs167.	Proline	110-113	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	24-28
14761940-6	2004	The interaction between Rsp5 and Rvs167 is mediated through Rsp5 WW domains and PXY motifs in the central Gly-Pro-Ala-rich domain of Rvs167.	Proline	110-113	amphiphysin	Saccharomyces cerevisiae S288C	33-39
14722089-3	2004	Here we studied the functional roles of sub-domains within the SLP-76 proline-rich region, specifically the Gads binding domain and the recently defined P1 domain.	Proline	70-77	lymphocyte cytosolic protein 2	Homo sapiens	63-69
15144596-10	2004	CONCLUSION: The antisense Smad(4) gene inhibits the expression of Smad(4) mRNA and protein, proline incorporation and cell growth, thus down-regulating the production of ECM.	Proline	92-99	SMAD family member 4	Rattus norvegicus	26-33
14742440-0	2004	Phospholipase D is a negative regulator of proline biosynthesis in Arabidopsis thaliana.	Proline	43-50	phospholipase D alpha 1	Arabidopsis thaliana	0-15
14742440-3	2004	We provide experimental evidence that phospholipase D (PLD) is involved in the regulation of proline metabolism in Arabidopsis thaliana.	Proline	93-100	phospholipase D alpha 1	Arabidopsis thaliana	38-53
14742440-3	2004	We provide experimental evidence that phospholipase D (PLD) is involved in the regulation of proline metabolism in Arabidopsis thaliana.	Proline	93-100	phospholipase D alpha 1	Arabidopsis thaliana	55-58
14742440-4	2004	The application of primary butyl alcohols, which divert part of PLD-derived phosphatidic acid by transphosphatidylation, stimulated proline biosynthesis even without hyperosmotic constraints.	Proline	132-139	phospholipase D alpha 1	Arabidopsis thaliana	64-67
14742440-7	2004	We clearly demonstrate that PLD signaling for proline biosynthesis is similar to RD29A gene expression and different from the abscisic acid-dependent RAB18 gene expression.	Proline	46-53	phospholipase D alpha 1	Arabidopsis thaliana	28-31
14742440-7	2004	We clearly demonstrate that PLD signaling for proline biosynthesis is similar to RD29A gene expression and different from the abscisic acid-dependent RAB18 gene expression.	Proline	46-53	low-temperature-responsive protein 78 (LTI78) / desiccation-responsive protein 29A (RD29A)	Arabidopsis thaliana	81-86
15070408-4	2004	NAP-1 encodes an 85 amino acid alkaline peptide with a calculated isoelectric point of 9.3, three phosphorilation sites and a proline-rich region.	Proline	126-133	nucleosome assembly protein 1 like 1	Homo sapiens	0-5
14736876-3	2004	The domain structure of WTIP is similar to the zyxin subfamily of cytosolic LIM domain-containing proteins, which contain three carboxyl-terminal LIM protein-protein interaction domains and a proline-rich, pre-LIM region with a nuclear export signal.	Proline	192-199	WT1 interacting protein	Mus musculus	24-28
14744858-4	2004	The second molecule represents a truncated form of the pro-domain of the Drosophila attacin C carrying two post-translational modifications and has significant structural similarities to proline-rich antibacterial peptides including drosocin.	Proline	187-194	Attacin-C	Drosophila melanogaster	84-93
15067030-2	2004	In human histocompatibility leukocyte antigen (HLA)-B57+ HIV-infected persons, immune selection pressure leads to a mutation from alanine to proline at Gag residue 146 immediately preceding the NH2 terminus of a dominant HLA-B57-restricted epitope, ISPRTLNAW.	Proline	141-148	major histocompatibility complex, class I, B	Homo sapiens	221-226
14680478-0	2004	Proline residues in transmembrane segment IV are critical for activity, expression and targeting of the Na+/H+ exchanger isoform 1.	Proline	0-7	solute carrier family 9 member A1	Homo sapiens	104-130
15039212-7	2004	In cases of LOH, there was a preferential loss of the proline allele, which was associated with an up-regulation of Bcl2 and lack of co-expression of Fas/FasL and, thus, impaired apoptosis (P &lt; 0.001).	Proline	54-61	BCL2 apoptosis regulator	Homo sapiens	116-120
15039212-7	2004	In cases of LOH, there was a preferential loss of the proline allele, which was associated with an up-regulation of Bcl2 and lack of co-expression of Fas/FasL and, thus, impaired apoptosis (P &lt; 0.001).	Proline	54-61	Fas ligand	Homo sapiens	154-158
15039212-13	2004	Homozygous proline 72 appears to be an important regulator of apoptosis via the Fas/FasL pathway in SCCHN.	Proline	11-18	Fas ligand	Homo sapiens	84-88
14680478-3	2004	We examined the importance of three conserved proline residues in TM IV (transmembrane segment IV) of NHE1.	Proline	46-53	solute carrier family 9 member A1	Homo sapiens	102-106
15041222-4	2004	The TP53 gene has a single polymorphism at codon 72 of exon 4 that encodes either arginine (Arg) or proline (Pro).	Proline	100-107	tumor protein p53	Homo sapiens	4-8
15056851-8	2004	For cleavage of the N-glycosidic bond, bifunctional DNA glycosylases (hNTH1, hNEIL1, hNEIL2, and hOGG1) use Lys or Pro for direct attack on sugar C1", whereas monofunctional DNA glycosylases (hSMUG1 and hMYH) use an activated water molecule.	Proline	115-118	nth like DNA glycosylase 1	Homo sapiens	70-75
15056851-8	2004	For cleavage of the N-glycosidic bond, bifunctional DNA glycosylases (hNTH1, hNEIL1, hNEIL2, and hOGG1) use Lys or Pro for direct attack on sugar C1", whereas monofunctional DNA glycosylases (hSMUG1 and hMYH) use an activated water molecule.	Proline	115-118	nei like DNA glycosylase 1	Homo sapiens	77-83
15056851-8	2004	For cleavage of the N-glycosidic bond, bifunctional DNA glycosylases (hNTH1, hNEIL1, hNEIL2, and hOGG1) use Lys or Pro for direct attack on sugar C1", whereas monofunctional DNA glycosylases (hSMUG1 and hMYH) use an activated water molecule.	Proline	115-118	nei like DNA glycosylase 2	Homo sapiens	85-91
15056851-8	2004	For cleavage of the N-glycosidic bond, bifunctional DNA glycosylases (hNTH1, hNEIL1, hNEIL2, and hOGG1) use Lys or Pro for direct attack on sugar C1", whereas monofunctional DNA glycosylases (hSMUG1 and hMYH) use an activated water molecule.	Proline	115-118	8-oxoguanine DNA glycosylase	Homo sapiens	97-102
15056851-8	2004	For cleavage of the N-glycosidic bond, bifunctional DNA glycosylases (hNTH1, hNEIL1, hNEIL2, and hOGG1) use Lys or Pro for direct attack on sugar C1", whereas monofunctional DNA glycosylases (hSMUG1 and hMYH) use an activated water molecule.	Proline	115-118	single-strand-selective monofunctional uracil-DNA glycosylase 1	Homo sapiens	192-198
15056851-8	2004	For cleavage of the N-glycosidic bond, bifunctional DNA glycosylases (hNTH1, hNEIL1, hNEIL2, and hOGG1) use Lys or Pro for direct attack on sugar C1", whereas monofunctional DNA glycosylases (hSMUG1 and hMYH) use an activated water molecule.	Proline	115-118	mutY DNA glycosylase	Homo sapiens	203-207
15041222-4	2004	The TP53 gene has a single polymorphism at codon 72 of exon 4 that encodes either arginine (Arg) or proline (Pro).	Proline	109-112	tumor protein p53	Homo sapiens	4-8
14718599-0	2004	Transport of pharmacologically active proline derivatives by the human proton-coupled amino acid transporter hPAT1.	Proline	38-45	solute carrier family 36 member 1	Homo sapiens	109-114
15066173-1	2004	The C-terminal t peptide (40 residues) of vertebrate acetylcholinesterase (AChE) T subunits possesses a series of seven conserved aromatic residues and forms an amphiphilic alpha-helix; it allows the formation of homo-oligomers (monomers, dimers and tetramers) and heteromeric associations with the anchoring proteins, ColQ and PRiMA, which contain a proline-rich motif (PRAD).	Proline	351-358	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-73
15066173-1	2004	The C-terminal t peptide (40 residues) of vertebrate acetylcholinesterase (AChE) T subunits possesses a series of seven conserved aromatic residues and forms an amphiphilic alpha-helix; it allows the formation of homo-oligomers (monomers, dimers and tetramers) and heteromeric associations with the anchoring proteins, ColQ and PRiMA, which contain a proline-rich motif (PRAD).	Proline	351-358	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-79
15053863-5	2004	Proline at position 140 and the surrounding amino acids of the human MGMT are highly conserved in the canine sequence.	Proline	0-7	O-6-methylguanine-DNA methyltransferase	Homo sapiens	69-73
15010845-11	2004	Human GUKH2 and GUKH1, consisting of eight GUKH homology (GKH1-GKH8) domains and Proline-rich domain, showed 28.5% total-amino-acid identity.	Proline	81-88	NHS-like 1b	Danio rerio	6-11
15010845-11	2004	Human GUKH2 and GUKH1, consisting of eight GUKH homology (GKH1-GKH8) domains and Proline-rich domain, showed 28.5% total-amino-acid identity.	Proline	81-88	GUK-holder	Drosophila melanogaster	6-10
14718599-2	2004	This study was performed to investigate whether the recently discovered human proton-coupled amino acid transporter 1 (hPAT1) is capable of transporting such pharmacologically relevant proline derivatives and also GABA analogs.	Proline	185-192	solute carrier family 36 member 1	Homo sapiens	78-117
14718599-2	2004	This study was performed to investigate whether the recently discovered human proton-coupled amino acid transporter 1 (hPAT1) is capable of transporting such pharmacologically relevant proline derivatives and also GABA analogs.	Proline	185-192	solute carrier family 36 member 1	Homo sapiens	119-124
14718599-4	2004	The L-proline uptake was saturable and mediated by a single transport system (hPAT1) with an affinity constant of 2.0 +/- 0.2 mM.	Proline	4-13	solute carrier family 36 member 1	Homo sapiens	78-83
14718599-6	2004	Apical uptake and transepithelial flux of L-[3H]proline across Caco-2 cell monolayers were strongly inhibited by proline derivatives in proportions corresponding to their respective affinity constants at hPAT1.	Proline	48-55	solute carrier family 36 member 1	Homo sapiens	204-209
14718599-10	2004	We conclude that 1) the substrate specificity of hPAT1 is very much broader than so far reported and 2) the system accepts therapeutically relevant proline and GABA derivatives.	Proline	148-155	solute carrier family 36 member 1	Homo sapiens	49-54
15050972-3	2004	A mitochondrial form, AII, has been thought to be more widely expressed and to be involved in the biosynthesis of polyamines, the amino acids ornithine, proline, and glutamate and in the inflammatory process, among others.	Proline	153-160	NLR family pyrin domain containing 3	Homo sapiens	22-25
15098931-1	2004	The objective of this immunohistochemical research was to reveal the distribution of a proline-rich peptide-1 (PRP-1) in various brain structures of intact and trauma-injured rats and to identify the mechanisms of promotion of neuronal recovery processes following PRP-1 treatment.	Proline	87-94	chloride channel accessory 4	Rattus norvegicus	111-114
15077666-9	2004	Pro accumulation was faster and stronger when stimulated by avrRpm1 than by avrRpt2, and was compromised in the low-salicylic acid plants NahG and eds5 when signaled through the RPS2-dependent pathway.	Proline	0-3	NB-ARC domain-containing disease resistance protein	Arabidopsis thaliana	178-182
15077666-10	2004	In addition, Pro content and AtP5CS2 expression were enhanced by ROS in wild-type plants, suggesting that ROS may function as an intermediate signal in AtP5CS2-mediated Pro accumulation.	Proline	13-16	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	152-159
15077666-10	2004	In addition, Pro content and AtP5CS2 expression were enhanced by ROS in wild-type plants, suggesting that ROS may function as an intermediate signal in AtP5CS2-mediated Pro accumulation.	Proline	169-172	delta 1-pyrroline-5-carboxylate synthase 2	Arabidopsis thaliana	152-159
14709551-3	2004	We report here that NS5A binds directly to the Src homology 3 domain of the p85 regulatory subunit of phosphoinositide 3-kinase (PI3K), and this interaction is mediated by a novel (non-proline-rich) motif within NS5A.	Proline	185-192	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	102-127
15082314-3	2004	Pin1 is a highly conserved enzyme that isomerizes only the phosphorylated Ser/Thr-Pro bonds in certain proteins, thereby inducing conformational changes.	Proline	82-85	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
14986307-1	2004	Prolyl endopeptidase (EC 3.4.21.26, PEP), a serine protease that hydrolyzes peptides at the carboxyl side of proline residues, is involved in the breakdown of several proline-containing neuropeptides and, thus, may contribute to the regulation of behavioral activities.	Proline	109-116	prolyl endopeptidase	Rattus norvegicus	0-20
14986307-1	2004	Prolyl endopeptidase (EC 3.4.21.26, PEP), a serine protease that hydrolyzes peptides at the carboxyl side of proline residues, is involved in the breakdown of several proline-containing neuropeptides and, thus, may contribute to the regulation of behavioral activities.	Proline	167-174	prolyl endopeptidase	Rattus norvegicus	0-20
15062083-6	2004	We propose this SH3 domain variant to be classified as a helically extended SH3 domain (hSH3 domain) and show that the ADAP-hSH3 domain can no longer bind conventional proline-rich peptides.	Proline	168-175	FYN binding protein	Mus musculus	119-123
14684745-4	2004	Unlike other Nedd4/Rsp5p family members, itch possesses a short proline-rich domain that mediates its binding to the SH3 domain of endophilin A1.	Proline	64-71	itchy E3 ubiquitin protein ligase	Homo sapiens	41-45
14722114-0	2004	Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions.	Proline	18-25	ATP binding cassette subfamily B member 1	Homo sapiens	88-118
14722114-0	2004	Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions.	Proline	18-25	ATP binding cassette subfamily C member 1	Homo sapiens	120-124
14722114-0	2004	Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions.	Proline	18-25	ATP binding cassette subfamily C member 1	Homo sapiens	125-130
14722125-7	2004	Sequencing of Stat2 RNA reveals a substitution of proline 630 located within the Src homology 2 domain of Stat2 to leucine (P630L).	Proline	50-57	signal transducer and activator of transcription 2	Homo sapiens	14-19
14722125-7	2004	Sequencing of Stat2 RNA reveals a substitution of proline 630 located within the Src homology 2 domain of Stat2 to leucine (P630L).	Proline	50-57	signal transducer and activator of transcription 2	Homo sapiens	106-111
15020763-4	2004	The gluten peptide-DQ2 complex retains critical hydrogen bonds between the MHC and the peptide backbone despite the presence of many proline residues in the peptide that are unable to participate in amide-mediated hydrogen bonds.	Proline	133-140	torsin family 1 member A	Homo sapiens	19-22
15020763-6	2004	The HLA association in celiac disease can be explained by a superior ability of DQ2 to bind the biased repertoire of proline-rich gluten peptides that have survived gastrointestinal digestion and that have been deamidated by tissue transglutaminase.	Proline	117-124	torsin family 1 member A	Homo sapiens	80-83
14684745-4	2004	Unlike other Nedd4/Rsp5p family members, itch possesses a short proline-rich domain that mediates its binding to the SH3 domain of endophilin A1.	Proline	64-71	SH3 domain containing GRB2 like 2, endophilin A1	Homo sapiens	131-144
14684745-5	2004	Itch ubiquitinates endophilin A1 and the SH3/proline-rich domain interaction facilitates this activity.	Proline	45-52	itchy E3 ubiquitin protein ligase	Homo sapiens	0-4
14684745-5	2004	Itch ubiquitinates endophilin A1 and the SH3/proline-rich domain interaction facilitates this activity.	Proline	45-52	SH3 domain containing GRB2 like 2, endophilin A1	Homo sapiens	19-32
15014124-4	2004	Affinity-purification experiments demonstrate that the interactions are mediated by the Abp1 (actin-binding protein 1) SH3 (Src homology 3) domain, which associates with a proline-rich motif that is conserved within the C-terminal parts of ProSAP1(proline-rich synapse-associated protein 1)/Shank2 and ProSAP2/Shank3.	Proline	172-179	drebrin like	Homo sapiens	88-92
15041957-9	2004	Sequencing of the CRYGA-CRYGD cluster identified a C-&gt;A transversion in exon 2 of CRYGD that was predicted to result in the non-conservative substitution of threonine for proline at amino-acid residue 23 (P23T) in the processed CRYGD protein.	Proline	174-181	crystallin gamma A	Homo sapiens	18-23
15041957-9	2004	Sequencing of the CRYGA-CRYGD cluster identified a C-&gt;A transversion in exon 2 of CRYGD that was predicted to result in the non-conservative substitution of threonine for proline at amino-acid residue 23 (P23T) in the processed CRYGD protein.	Proline	174-181	crystallin gamma D	Homo sapiens	24-29
15041957-9	2004	Sequencing of the CRYGA-CRYGD cluster identified a C-&gt;A transversion in exon 2 of CRYGD that was predicted to result in the non-conservative substitution of threonine for proline at amino-acid residue 23 (P23T) in the processed CRYGD protein.	Proline	174-181	crystallin gamma D	Homo sapiens	85-90
15041957-9	2004	Sequencing of the CRYGA-CRYGD cluster identified a C-&gt;A transversion in exon 2 of CRYGD that was predicted to result in the non-conservative substitution of threonine for proline at amino-acid residue 23 (P23T) in the processed CRYGD protein.	Proline	174-181	crystallin gamma D	Homo sapiens	85-90
14679214-7	2004	A proline-rich sequence of Son of Sevenless also specifically bound Grb2, demonstrating that the screen maintains specificity with low affinity interactions.	Proline	2-9	growth factor receptor bound protein 2	Homo sapiens	68-72
14701857-2	2004	Hydroxylation of specific proline residues by HIF prolyl 4-hydroxylases targets the HIF-alpha subunit for proteasomal destruction, whereas hydroxylation of an asparagine in the C-terminal transactivation domain prevents its interaction with the transcriptional coactivator p300.	Proline	26-33	E1A binding protein p300	Homo sapiens	273-277
15023352-3	2004	ERK2 catalyses the transfer of the gamma-phosphate of adenosine triphosphate to serine or threonine residues found in Ser-Pro or Thr-Pro motifs on proteins.	Proline	122-125	mitogen-activated protein kinase 1	Homo sapiens	0-4
15023352-3	2004	ERK2 catalyses the transfer of the gamma-phosphate of adenosine triphosphate to serine or threonine residues found in Ser-Pro or Thr-Pro motifs on proteins.	Proline	133-136	mitogen-activated protein kinase 1	Homo sapiens	0-4
15023357-3	2004	Cdk5, however, is unique to this family of proline-directed serine/threonine kinases on two accounts.	Proline	43-50	cyclin dependent kinase 5	Homo sapiens	0-4
15014124-4	2004	Affinity-purification experiments demonstrate that the interactions are mediated by the Abp1 (actin-binding protein 1) SH3 (Src homology 3) domain, which associates with a proline-rich motif that is conserved within the C-terminal parts of ProSAP1(proline-rich synapse-associated protein 1)/Shank2 and ProSAP2/Shank3.	Proline	172-179	drebrin like	Homo sapiens	94-117
15014124-4	2004	Affinity-purification experiments demonstrate that the interactions are mediated by the Abp1 (actin-binding protein 1) SH3 (Src homology 3) domain, which associates with a proline-rich motif that is conserved within the C-terminal parts of ProSAP1(proline-rich synapse-associated protein 1)/Shank2 and ProSAP2/Shank3.	Proline	172-179	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	240-247
15014124-4	2004	Affinity-purification experiments demonstrate that the interactions are mediated by the Abp1 (actin-binding protein 1) SH3 (Src homology 3) domain, which associates with a proline-rich motif that is conserved within the C-terminal parts of ProSAP1(proline-rich synapse-associated protein 1)/Shank2 and ProSAP2/Shank3.	Proline	172-179	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	248-289
15014124-4	2004	Affinity-purification experiments demonstrate that the interactions are mediated by the Abp1 (actin-binding protein 1) SH3 (Src homology 3) domain, which associates with a proline-rich motif that is conserved within the C-terminal parts of ProSAP1(proline-rich synapse-associated protein 1)/Shank2 and ProSAP2/Shank3.	Proline	172-179	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	291-297
15014124-4	2004	Affinity-purification experiments demonstrate that the interactions are mediated by the Abp1 (actin-binding protein 1) SH3 (Src homology 3) domain, which associates with a proline-rich motif that is conserved within the C-terminal parts of ProSAP1(proline-rich synapse-associated protein 1)/Shank2 and ProSAP2/Shank3.	Proline	172-179	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	302-309
15014124-4	2004	Affinity-purification experiments demonstrate that the interactions are mediated by the Abp1 (actin-binding protein 1) SH3 (Src homology 3) domain, which associates with a proline-rich motif that is conserved within the C-terminal parts of ProSAP1(proline-rich synapse-associated protein 1)/Shank2 and ProSAP2/Shank3.	Proline	172-179	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	310-316
14999080-5	2004	For chorda tympani responses, significant linkages to Tas1r3 were found for the sweeteners sucrose, saccharin, D-phenylalanine, D-tryptophan, and SC-45647 but not glycine, L-proline, L-alanine, or L-glutamine.	Proline	172-181	taste receptor, type 1, member 3	Mus musculus	54-60
14681225-5	2004	By using the peptidylprolyl isomerase, Pin1, as a probe for proline-directed phosphorylation, we show that ERK1/2-dependent phosphorylation of Bim(EL) occurs at (S/T)P motifs.	Proline	60-67	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	39-43
14681225-5	2004	By using the peptidylprolyl isomerase, Pin1, as a probe for proline-directed phosphorylation, we show that ERK1/2-dependent phosphorylation of Bim(EL) occurs at (S/T)P motifs.	Proline	60-67	mitogen-activated protein kinase 3	Homo sapiens	107-113
14681225-5	2004	By using the peptidylprolyl isomerase, Pin1, as a probe for proline-directed phosphorylation, we show that ERK1/2-dependent phosphorylation of Bim(EL) occurs at (S/T)P motifs.	Proline	60-67	BCL2 like 11	Homo sapiens	143-150
15037072-11	2004	The more open pocket of the Ricinus CysEP correlates with the extended variety of substrate amino acid residues accommodated by this enzyme, including even proline at the P1 and P1" positions.	Proline	156-163	vignain	Ricinus communis	36-41
14871470-2	2004	Among them, transmembrane Trx-related protein (TMX) was recently identified as a novel protein possessing an atypical active site sequence, Cys-Pro-Ala-Cys.	Proline	144-147	thioredoxin related transmembrane protein 1	Homo sapiens	12-45
14871470-2	2004	Among them, transmembrane Trx-related protein (TMX) was recently identified as a novel protein possessing an atypical active site sequence, Cys-Pro-Ala-Cys.	Proline	144-147	thioredoxin related transmembrane protein 1	Homo sapiens	47-50
14668477-2	2004	Here, we show that two proline residues (P1330 and P1333) in this region of the connecting segment are critical for supporting beta4-mediated recruitment of plectin.	Proline	23-30	tubulin beta 3 class III	Homo sapiens	127-132
14973281-4	2004	The JAG gene was identified by map-based cloning to be a member of the zinc finger family of plant transcription factors and encodes a protein similar in structure to SUPERMAN with a single C(2)H(2)-type zinc finger, a proline-rich motif and a short leucine-rich repressor motif.	Proline	219-226	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	4-7
14693913-6	2004	The C-terminal 192 residues of hBSSL contain 16 Pro-rich 11-amino-acid repeats, which include 32 Ser/Thr residues as potential O-glycosylation sites.	Proline	48-51	carboxyl ester lipase	Homo sapiens	31-36
15027030-9	2004	In addition we found that peptides corresponding to the Arg(255)-Ser(267), Lys(288)-Ser(298) or Pro(230)-Val(240) when presented in a multimeric form conjugated to branched chain polypeptide in uniformly oriented copies induced the release of TNFalpha, a pro-inflammatory cytokine from MonoMac monocyte cell line.	Proline	96-99	tumor necrosis factor	Homo sapiens	243-251
14668477-2	2004	Here, we show that two proline residues (P1330 and P1333) in this region of the connecting segment are critical for supporting beta4-mediated recruitment of plectin.	Proline	23-30	plectin	Homo sapiens	157-164
14758354-4	2004	Comparison of the proline-rich sequence (PRS)-binding sites in this family of proteins with Dcp1p indicates that it belongs to a novel class of EVH1 domains.	Proline	18-25	decapping mRNA 1B	Homo sapiens	92-97
15832508-5	2004	For all nucleoside parent drugs, BPHL preferred the hydrophobic amino acids valine, phenylalanine, and proline over the charged amino acids lysine and aspartic acid.	Proline	103-110	biphenyl hydrolase like	Homo sapiens	33-37
14993270-3	2004	It was previously shown that Rac-p21-activated kinase (PAK) signaling regulated the physical association of MEK1 with ERK2 through phosphorylation sites in the proline-rich sequence (PRS) of MEK1.	Proline	160-167	mitogen-activated protein kinase kinase 1	Homo sapiens	108-112
14993270-3	2004	It was previously shown that Rac-p21-activated kinase (PAK) signaling regulated the physical association of MEK1 with ERK2 through phosphorylation sites in the proline-rich sequence (PRS) of MEK1.	Proline	160-167	mitogen-activated protein kinase 1	Homo sapiens	118-122
14993270-3	2004	It was previously shown that Rac-p21-activated kinase (PAK) signaling regulated the physical association of MEK1 with ERK2 through phosphorylation sites in the proline-rich sequence (PRS) of MEK1.	Proline	160-167	mitogen-activated protein kinase kinase 1	Homo sapiens	191-195
15047879-1	2004	A 6-bp sequence, ACTCAT, acts as a cis-acting element involved in hypoosmolarity- and proline-responsive expression of an Arabidopsis proline dehydrogenase (ProDH) gene.	Proline	86-93	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	134-155
15134872-3	2004	The key to conversion of bradykinin into an antagonist was replacement of the proline residue at position 7 with a D-aromatic amino acid.	Proline	78-85	kininogen 1	Homo sapiens	25-35
14652689-1	2004	A novel acetyltransferase (Mpr1) found in Saccharomyces cerevisiae (strain Sigma1278b) has been shown to specifically detoxify a proline analog, l-azetidine-2-carboxylic acid (A2C) in yeast cells [M. Shichiri et al.	Proline	129-136	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	27-31
14652689-10	2004	Our studies confirm that MPR1 can function in a similar fashion in tobacco as in yeast to detoxify the toxic proline analog A2C, so it could potentially be used as a new selectable marker for plant transformation.	Proline	109-116	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	25-29
15047879-1	2004	A 6-bp sequence, ACTCAT, acts as a cis-acting element involved in hypoosmolarity- and proline-responsive expression of an Arabidopsis proline dehydrogenase (ProDH) gene.	Proline	86-93	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	157-162
14660656-3	2004	The anomalously enhanced (229 nm) ultraviolet resonance Raman (UVRR) imide II band reveals a common structural feature for gels of nondehydrated tau 2-19 and collagen I and insoluble paired helical filaments (PHFs) and collagen I of weak hydrogen bonding at proline carbonyls.	Proline	258-265	microtubule associated protein tau	Homo sapiens	145-148
14978303-1	2004	The Caenorhabditis elegans SEM-5 SH3 domains recognize proline-rich peptide segments with modest affinity.	Proline	55-62	Sex muscle abnormal protein 5	Caenorhabditis elegans	27-32
15056918-4	2004	In this paper, we report the large scale preparation of a stable, homogenous species, truncated octopus rhodopsin (t-rhodopsin) in which proteolysis has removed the proline-rich C-terminal; this species retains the spectral properties and the ability for light-induced G-protein activation of unproteolyzed octopus rhodopsin.	Proline	165-172	rhodopsin	Bos taurus	104-113
15056918-4	2004	In this paper, we report the large scale preparation of a stable, homogenous species, truncated octopus rhodopsin (t-rhodopsin) in which proteolysis has removed the proline-rich C-terminal; this species retains the spectral properties and the ability for light-induced G-protein activation of unproteolyzed octopus rhodopsin.	Proline	165-172	rhodopsin	Bos taurus	117-126
15056918-4	2004	In this paper, we report the large scale preparation of a stable, homogenous species, truncated octopus rhodopsin (t-rhodopsin) in which proteolysis has removed the proline-rich C-terminal; this species retains the spectral properties and the ability for light-induced G-protein activation of unproteolyzed octopus rhodopsin.	Proline	165-172	rhodopsin	Bos taurus	117-126
14625282-12	2004	This view is supported by recent studies of recombinant elastin polypeptides with systematic proline substitutions.	Proline	93-100	elastin	Homo sapiens	56-63
14660656-5	2004	In aged, dehydrated tau 2-19 gel, proline carbonyls lose their bonds to water and tyrosine becomes deprotonated, as demonstrated by UVRR spectroscopy.	Proline	34-41	microtubule associated protein tau	Homo sapiens	20-23
14765109-1	2004	The Cdc14 family of phosphatases specifically reverses proline-directed phosphorylation events.	Proline	55-62	phosphoprotein phosphatase CDC14	Saccharomyces cerevisiae S288C	4-9
14670950-3	2004	Enzymatic deglycosylation, site-directed mutagenesis, and lectin precipitation assays were used to demonstrate that MT1-MMP contains O-linked complex carbohydrates on the Thr(291), Thr(299), Thr(300), and/or Ser(301) residues in the proline-rich linker region.	Proline	233-240	matrix metallopeptidase 14	Homo sapiens	116-123
14670955-2	2004	We have identified two proline-rich, SH3 binding sites (PXXP) in the carboxyl-terminal tail of the human P2Y(2) nucleotide receptor that directly associate with the tyrosine kinase Src in protein binding assays.	Proline	23-30	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	181-184
14967049-9	2004	Phosphorylation in bovine NFM occurs mainly in the Lys-Ser-Pro (KSP) region, but the Val-Ser-Pro and Ser-Glu-Lys motifs are also phosphorylated.	Proline	59-62	neurofilament medium chain	Bos taurus	26-29
14551139-3	2004	In this study, we have identified and characterized EBP, a novel EEN binding protein that interacts with the SH3 domain of EEN through a proline-rich motif PPERP.	Proline	137-144	EBP cholestenol delta-isomerase	Homo sapiens	52-55
14660601-0	2004	A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase.	Proline	12-19	glycosylphosphatidylinositol anchor attachment 1	Homo sapiens	57-61
14660601-0	2004	A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase.	Proline	12-19	phosphatidylinositol glycan anchor biosynthesis class K	Sus scrofa	128-144
14660601-10	2004	We go on to show that mutation of a conserved proline residue centrally located within the C-terminal TM span of Gaa1 is sufficient to abrogate the ability of the resulting GPIT complex to co-immunoprecipitate GPI.	Proline	46-53	glycosylphosphatidylinositol anchor attachment 1	Homo sapiens	113-117
14660601-10	2004	We go on to show that mutation of a conserved proline residue centrally located within the C-terminal TM span of Gaa1 is sufficient to abrogate the ability of the resulting GPIT complex to co-immunoprecipitate GPI.	Proline	46-53	phosphatidylinositol glycan anchor biosynthesis class K	Sus scrofa	173-177
14660601-11	2004	We suggest that the putative dynamic hinge created by the proline residue provides a structural basis for the interaction of GPI with GPIT.	Proline	58-65	phosphatidylinositol glycan anchor biosynthesis class K	Sus scrofa	134-138
14551139-3	2004	In this study, we have identified and characterized EBP, a novel EEN binding protein that interacts with the SH3 domain of EEN through a proline-rich motif PPERP.	Proline	137-144	SH3 domain containing GRB2 like 1, endophilin A2	Homo sapiens	123-126
14551139-3	2004	In this study, we have identified and characterized EBP, a novel EEN binding protein that interacts with the SH3 domain of EEN through a proline-rich motif PPERP.	Proline	137-144	SH3 domain containing GRB2 like 1, endophilin A2	Homo sapiens	65-68
14612446-3	2004	Despite their exclusion from protein surfaces, the periplasmic ligand-binding protein ProX from the Escherichia coli ATP-binding cassette transport system ProU binds the compatible solutes glycine betaine and proline betaine with high affinity and specificity.	Proline	209-216	ATPase	Escherichia coli	117-120
14625308-9	2004	Third, IRAK-1 autophosphorylates several times in the proline-, serine-, and threonine-rich ProST region between the N-terminal death domain and kinase domain.	Proline	54-61	interleukin 1 receptor associated kinase 1	Homo sapiens	7-13
14755689-7	2004	To alter the structure of the alpha-helix, a leucine to proline mutation was generated in the AFAP-110 alpha-helical Lzip motif (AFAP-110(581P)), which largely preserved the sequence.	Proline	56-63	actin filament associated protein 1	Homo sapiens	94-102
14755689-7	2004	To alter the structure of the alpha-helix, a leucine to proline mutation was generated in the AFAP-110 alpha-helical Lzip motif (AFAP-110(581P)), which largely preserved the sequence.	Proline	56-63	cAMP responsive element binding protein 3	Homo sapiens	117-121
14755689-7	2004	To alter the structure of the alpha-helix, a leucine to proline mutation was generated in the AFAP-110 alpha-helical Lzip motif (AFAP-110(581P)), which largely preserved the sequence.	Proline	56-63	actin filament associated protein 1	Homo sapiens	129-137
15065439-0	2004	[Increase in the level of proline and osmotic pressure of cytoplasm in transformed tobacco bearing an antisense suppressor of the proline dehydrogenase gene].	Proline	26-33	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	130-151
14756569-3	2004	The low activity can be ascribed to the rigid nature of the proline residue at position 47 as the activity can be increased by approximately 100-fold by substituting Pro47 with either His (as found in human ADH2), Ala, or Gln.	Proline	60-67	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	207-211
14757063-3	2004	We present here a complete thermodynamic analysis of the binding energetics of the p41 proline-rich decapeptide (APSYSPPPPP) to the SH3 domain of the c-Abl oncogene.	Proline	87-94	mitogen-activated protein kinase 1	Homo sapiens	83-86
14757063-3	2004	We present here a complete thermodynamic analysis of the binding energetics of the p41 proline-rich decapeptide (APSYSPPPPP) to the SH3 domain of the c-Abl oncogene.	Proline	87-94	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	150-155
14757063-6	2004	The origin of the binding energetics for proline-rich ligands to the Abl-SH3 domain is further investigated by a comparative calorimetric analysis of a set of p41-related ligands.	Proline	41-48	mitogen-activated protein kinase 1	Homo sapiens	159-162
14689302-4	2004	The mutation, 83G--&gt;C, is predicted to result in the substitution of arginine by proline (R28P) in the N-terminal subdomain of PAX9 paired domain.	Proline	84-91	paired box 9	Homo sapiens	130-134
14968425-1	2004	We have found that proline and the toxic proline analogue azetidine-2-carboxylate (AzC) are efficiently imported into Saccharomyces cerevisiae cells by four amino acid permeases, including two nitrogen-regulated permeases (PUT4 and GAP1) and two permeases that are regulated by the SPS sensor of extracellular amino acids (AGP1 and GNP1).	Proline	19-26	proline permease PUT4	Saccharomyces cerevisiae S288C	223-227
12748860-4	2004	Both PAT1 and PAT2 mediate 1:1 symport of protons and small neutral amino acids such as glycine, alanine, and proline.	Proline	110-117	solute carrier family 36 member 1	Homo sapiens	5-9
12748860-4	2004	Both PAT1 and PAT2 mediate 1:1 symport of protons and small neutral amino acids such as glycine, alanine, and proline.	Proline	110-117	solute carrier family 36 member 2	Homo sapiens	14-18
14729963-4	2004	The N-terminal region containing the serine-rich (S) domain, the central RNA recognition motif (RRM), and the C-terminal arginine/serine/proline-rich (RS/P) domain of RNPS1 interact with p54, pinin, and hTra2 beta, respectively.	Proline	137-144	RNA binding protein with serine rich domain 1	Homo sapiens	167-172
15036368-3	2004	The polymorphism leads to a non-conservative amino acid change (R222W) located between the acetyltransferase (GNAT) and the proline-rich domains of the protein.	Proline	124-131	glycine-N-acyltransferase like 1	Homo sapiens	110-114
14760152-7	2004	CONCLUSIONS: The proline allele at codon 10 of the TGF-beta1 gene occurs more commonly in control subjects than in individuals with COPD.	Proline	17-24	transforming growth factor beta 1	Homo sapiens	51-60
14968425-1	2004	We have found that proline and the toxic proline analogue azetidine-2-carboxylate (AzC) are efficiently imported into Saccharomyces cerevisiae cells by four amino acid permeases, including two nitrogen-regulated permeases (PUT4 and GAP1) and two permeases that are regulated by the SPS sensor of extracellular amino acids (AGP1 and GNP1).	Proline	19-26	amino acid permease GAP1	Saccharomyces cerevisiae S288C	232-236
14968425-1	2004	We have found that proline and the toxic proline analogue azetidine-2-carboxylate (AzC) are efficiently imported into Saccharomyces cerevisiae cells by four amino acid permeases, including two nitrogen-regulated permeases (PUT4 and GAP1) and two permeases that are regulated by the SPS sensor of extracellular amino acids (AGP1 and GNP1).	Proline	19-26	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	323-327
14968425-1	2004	We have found that proline and the toxic proline analogue azetidine-2-carboxylate (AzC) are efficiently imported into Saccharomyces cerevisiae cells by four amino acid permeases, including two nitrogen-regulated permeases (PUT4 and GAP1) and two permeases that are regulated by the SPS sensor of extracellular amino acids (AGP1 and GNP1).	Proline	19-26	glutamine permease GNP1	Saccharomyces cerevisiae S288C	332-336
14968425-1	2004	We have found that proline and the toxic proline analogue azetidine-2-carboxylate (AzC) are efficiently imported into Saccharomyces cerevisiae cells by four amino acid permeases, including two nitrogen-regulated permeases (PUT4 and GAP1) and two permeases that are regulated by the SPS sensor of extracellular amino acids (AGP1 and GNP1).	Proline	41-48	proline permease PUT4	Saccharomyces cerevisiae S288C	223-227
14968425-1	2004	We have found that proline and the toxic proline analogue azetidine-2-carboxylate (AzC) are efficiently imported into Saccharomyces cerevisiae cells by four amino acid permeases, including two nitrogen-regulated permeases (PUT4 and GAP1) and two permeases that are regulated by the SPS sensor of extracellular amino acids (AGP1 and GNP1).	Proline	41-48	amino acid permease GAP1	Saccharomyces cerevisiae S288C	232-236
14968425-1	2004	We have found that proline and the toxic proline analogue azetidine-2-carboxylate (AzC) are efficiently imported into Saccharomyces cerevisiae cells by four amino acid permeases, including two nitrogen-regulated permeases (PUT4 and GAP1) and two permeases that are regulated by the SPS sensor of extracellular amino acids (AGP1 and GNP1).	Proline	41-48	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	323-327
14968425-1	2004	We have found that proline and the toxic proline analogue azetidine-2-carboxylate (AzC) are efficiently imported into Saccharomyces cerevisiae cells by four amino acid permeases, including two nitrogen-regulated permeases (PUT4 and GAP1) and two permeases that are regulated by the SPS sensor of extracellular amino acids (AGP1 and GNP1).	Proline	41-48	glutamine permease GNP1	Saccharomyces cerevisiae S288C	332-336
14594802-8	2004	In vitro, the high mobility group domain of LEF-1 interacts with the runt DNA binding and proline-, serine-, threonine-rich activation domains of CBFalpha.	Proline	90-97	lymphoid enhancer binding factor 1	Homo sapiens	44-49
14749431-3	2004	The N-terminal domain of PSD-95 contains three consensus phosphorylation sites for cyclin-dependent kinase 5 (cdk5), a proline-directed serine-threonine kinase essential for brain development and implicated in synaptic plasticity, dopamine signaling, cocaine addiction, and neurodegenerative disorders.	Proline	119-126	discs large MAGUK scaffold protein 4	Mus musculus	25-31
14749431-3	2004	The N-terminal domain of PSD-95 contains three consensus phosphorylation sites for cyclin-dependent kinase 5 (cdk5), a proline-directed serine-threonine kinase essential for brain development and implicated in synaptic plasticity, dopamine signaling, cocaine addiction, and neurodegenerative disorders.	Proline	119-126	cyclin-dependent kinase 5	Mus musculus	83-108
14749431-3	2004	The N-terminal domain of PSD-95 contains three consensus phosphorylation sites for cyclin-dependent kinase 5 (cdk5), a proline-directed serine-threonine kinase essential for brain development and implicated in synaptic plasticity, dopamine signaling, cocaine addiction, and neurodegenerative disorders.	Proline	119-126	cyclin-dependent kinase 5	Mus musculus	110-114
14600155-2	2004	PAT2 and its paralog, PAT1/LYAAT-1, are transporters for small amino acids such as glycine, alanine, and proline.	Proline	105-112	solute carrier family 36 member 2	Homo sapiens	0-4
14600155-2	2004	PAT2 and its paralog, PAT1/LYAAT-1, are transporters for small amino acids such as glycine, alanine, and proline.	Proline	105-112	solute carrier family 36 member 1	Homo sapiens	22-26
14600155-2	2004	PAT2 and its paralog, PAT1/LYAAT-1, are transporters for small amino acids such as glycine, alanine, and proline.	Proline	105-112	solute carrier family 36 member 1	Homo sapiens	27-34
14600155-9	2004	Our data suggest that PAT2 contributes to neuronal transport and sequestration of amino acids such as glycine, alanine, and/or proline, whereby the transport direction is dependent on the sum of the driving forces such as substrate concentration, pH gradient, and membrane potential.	Proline	127-134	solute carrier family 36 member 2	Homo sapiens	22-26
14594802-8	2004	In vitro, the high mobility group domain of LEF-1 interacts with the runt DNA binding and proline-, serine-, threonine-rich activation domains of CBFalpha.	Proline	90-97	Y-box binding protein 1	Homo sapiens	146-154
14594951-7	2004	Using CARMIL fusion proteins, the binding site for capping protein was shown to reside within the carboxyl-terminal, approximately 200 residue, proline-rich domain of CARMIL.	Proline	144-151	capping protein regulator and myosin 1 linker 1	Homo sapiens	6-12
14594951-7	2004	Using CARMIL fusion proteins, the binding site for capping protein was shown to reside within the carboxyl-terminal, approximately 200 residue, proline-rich domain of CARMIL.	Proline	144-151	capping protein regulator and myosin 1 linker 1	Homo sapiens	167-173
14697214-9	2004	Thus, the NLS consisting of a cluster of basic amino acids with Pro and Tyr at the C-terminal end is novel and well conserved in the SIM proteins during evolution.	Proline	64-67	SIM bHLH transcription factor 2	Homo sapiens	133-136
14585841-7	2004	We also define a 12-amino acid PXY repeat of the C-terminal proline-rich domain necessary for binding ALG-2.	Proline	60-67	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	102-107
14565953-3	2004	This protein contains a mucin tandem repeat of 19 amino acids consisting of many threonine, serine, and proline residues and likely to be extensively O-glycosylated; thus, this gene was classified in the mucin family and named MUC20.	Proline	104-111	mucin 20, cell surface associated	Homo sapiens	227-232
14989432-3	2004	METHODS: Oligosaccharides present in the proline-rich region in the C-terminus of BSSL were investigated using deglycosylating enzymes and lectin affinity probing to determine the origin of the multiple molecular forms.	Proline	41-48	carboxyl ester lipase	Homo sapiens	82-86
14715959-6	2004	Removal of a series of prolines adjacent to the polyglutamine region in htt blocked formation of the shell of the htt body and redistribution of dynamin, HIP1, SH3GL3, and proteasome to it.	Proline	23-31	huntingtin	Homo sapiens	72-75
14715959-6	2004	Removal of a series of prolines adjacent to the polyglutamine region in htt blocked formation of the shell of the htt body and redistribution of dynamin, HIP1, SH3GL3, and proteasome to it.	Proline	23-31	huntingtin	Homo sapiens	114-117
14715959-6	2004	Removal of a series of prolines adjacent to the polyglutamine region in htt blocked formation of the shell of the htt body and redistribution of dynamin, HIP1, SH3GL3, and proteasome to it.	Proline	23-31	huntingtin interacting protein 1	Homo sapiens	154-158
14715959-6	2004	Removal of a series of prolines adjacent to the polyglutamine region in htt blocked formation of the shell of the htt body and redistribution of dynamin, HIP1, SH3GL3, and proteasome to it.	Proline	23-31	SH3 domain containing GRB2 like 3, endophilin A3	Homo sapiens	160-166
14707117-5	2004	By contrast, WASp was tyrosine dephosphorylated by protein tyrosine phosphatase (PTP)-PEST, a tyrosine phosphatase shown here to interact with WASp via proline, serine, threonine phosphatase interacting protein (PSTPIP)1 binding.	Proline	152-159	Wiskott-Aldrich syndrome	Mus musculus	13-17
14707117-5	2004	By contrast, WASp was tyrosine dephosphorylated by protein tyrosine phosphatase (PTP)-PEST, a tyrosine phosphatase shown here to interact with WASp via proline, serine, threonine phosphatase interacting protein (PSTPIP)1 binding.	Proline	152-159	Wiskott-Aldrich syndrome	Mus musculus	18-21
14707117-5	2004	By contrast, WASp was tyrosine dephosphorylated by protein tyrosine phosphatase (PTP)-PEST, a tyrosine phosphatase shown here to interact with WASp via proline, serine, threonine phosphatase interacting protein (PSTPIP)1 binding.	Proline	152-159	protein tyrosine phosphatase, non-receptor type 12	Mus musculus	51-90
14707117-5	2004	By contrast, WASp was tyrosine dephosphorylated by protein tyrosine phosphatase (PTP)-PEST, a tyrosine phosphatase shown here to interact with WASp via proline, serine, threonine phosphatase interacting protein (PSTPIP)1 binding.	Proline	152-159	Wiskott-Aldrich syndrome	Mus musculus	143-147
14707117-5	2004	By contrast, WASp was tyrosine dephosphorylated by protein tyrosine phosphatase (PTP)-PEST, a tyrosine phosphatase shown here to interact with WASp via proline, serine, threonine phosphatase interacting protein (PSTPIP)1 binding.	Proline	152-159	proline-serine-threonine phosphatase-interacting protein 1	Mus musculus	212-220
14687797-4	2004	We found one LKB1 missense mutation, CCG--&gt;CTG (Pro--&gt;Leu) at codon 281 within the kinase domain.	Proline	51-54	serine/threonine kinase 11	Homo sapiens	13-17
14744727-1	2004	The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated as a risk marker in cervical neoplasia.	Proline	32-35	tumor protein p53	Homo sapiens	66-69
14744727-1	2004	The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated as a risk marker in cervical neoplasia.	Proline	39-42	tumor protein p53	Homo sapiens	66-69
14744727-1	2004	The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated as a risk marker in cervical neoplasia.	Proline	39-42	tumor protein p53	Homo sapiens	66-69
15218265-2	2004	VMD2, together with VMD2L1, VMD2L2 and VMD2L3, belong to a closely related gene family characterized by several transmembrane (TM) spanning helical domains and an invariant arginine, phenylalanine and proline (RFP) tripeptide motif, thus termed VMD2 RFP-TM.	Proline	201-208	bestrophin 1	Mus musculus	0-4
14686917-1	2004	Acetylcholinesterase subunits of type T (AChET) possess an alternatively spliced C-terminal peptide (t peptide) which endows them with amphiphilic properties, the capacity to form various homo-oligomers and to associate, as a tetramer, with anchoring proteins containing a proline rich attachment domain (PRAD).	Proline	273-280	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
14560963-8	2004	Another exogenous substrate phosphorylated by immunopurified mTOR in vitro is eIF4E-binding protein 1 (4E-BP1) at sites corresponding to those phosphorylated in vivo during insulin stimulation in a Ser/Thr-Pro motif.	Proline	206-209	mechanistic target of rapamycin kinase	Homo sapiens	61-65
14560963-8	2004	Another exogenous substrate phosphorylated by immunopurified mTOR in vitro is eIF4E-binding protein 1 (4E-BP1) at sites corresponding to those phosphorylated in vivo during insulin stimulation in a Ser/Thr-Pro motif.	Proline	206-209	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	78-101
14560963-8	2004	Another exogenous substrate phosphorylated by immunopurified mTOR in vitro is eIF4E-binding protein 1 (4E-BP1) at sites corresponding to those phosphorylated in vivo during insulin stimulation in a Ser/Thr-Pro motif.	Proline	206-209	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	103-109
15011833-8	2004	METHODOLOGY: In this study, we focused our aim on the degradation of p27kip1 protein mediated by a recombinant adenoviral expressing a mutant p27kip1 (Adp27-mt), which has a mutation of Thr-187/Pro-188 (ACGCCC) to Met-187/Ile-188 (ATGATC).	Proline	194-197	cyclin dependent kinase inhibitor 1B	Homo sapiens	69-76
15020407-4	2004	The Sho1p-Fus1p interaction occurs directly and is mediated through the Sho1p-SH3 domain and a proline-rich peptide ligand on the Fus1p COOH-terminal cytoplasmic region.	Proline	95-102	osmosensor SHO1	Saccharomyces cerevisiae S288C	4-9
15020407-4	2004	The Sho1p-Fus1p interaction occurs directly and is mediated through the Sho1p-SH3 domain and a proline-rich peptide ligand on the Fus1p COOH-terminal cytoplasmic region.	Proline	95-102	Fus1p	Saccharomyces cerevisiae S288C	10-15
15020407-4	2004	The Sho1p-Fus1p interaction occurs directly and is mediated through the Sho1p-SH3 domain and a proline-rich peptide ligand on the Fus1p COOH-terminal cytoplasmic region.	Proline	95-102	Fus1p	Saccharomyces cerevisiae S288C	130-135
14613973-8	2004	Hence, although analogous proline--&gt;arginine mutations in FGFR1-3 act through a common structural mechanism to result in gain-of-function, differences in the primary sequence among FGFRs result in varying effects on ligand binding specificity.	Proline	26-33	fibroblast growth factor receptor 1	Homo sapiens	61-66
15011833-8	2004	METHODOLOGY: In this study, we focused our aim on the degradation of p27kip1 protein mediated by a recombinant adenoviral expressing a mutant p27kip1 (Adp27-mt), which has a mutation of Thr-187/Pro-188 (ACGCCC) to Met-187/Ile-188 (ATGATC).	Proline	194-197	cyclin dependent kinase inhibitor 1B	Homo sapiens	142-149
14654988-10	2004	SH3 domain of FNBP1 family proteins interacts with proline-rich region of Formin and WASP family proteins.	Proline	51-58	formin binding protein 1	Homo sapiens	14-19
14613973-1	2004	Identical proline--&gt;arginine gain-of-function mutations in fibroblast growth factor receptor (FGFR) 1 (Pro252Arg), FGFR2 (Pro253Arg) and FGFR3 (Pro250Arg), result in type I Pfeiffer, Apert and Muenke craniosynostosis syndromes, respectively.	Proline	10-17	fibroblast growth factor receptor 3	Homo sapiens	140-145
14718626-6	2004	Deletion mutagenesis identified proline-rich repeats of sequence PPPKPC in the ASFV CD2v protein to be necessary and sufficient for binding to the SH3 domain of SH3P7.	Proline	32-39	drebrin-like	Mus musculus	161-166
14999017-3	2004	The region corresponding to amino acid residues 794 to 827 in the carboxy-terminal proline-rich region of Alix was sufficient to confer the ability to interact directly with ALG-2.	Proline	83-90	programmed cell death 6 interacting protein	Homo sapiens	106-110
14999017-3	2004	The region corresponding to amino acid residues 794 to 827 in the carboxy-terminal proline-rich region of Alix was sufficient to confer the ability to interact directly with ALG-2.	Proline	83-90	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	174-179
14999017-5	2004	Alanine substitutions indicated that seven proline residues in this region, four in the PxY repeats, and four tyrosine residues in the PxY repeats are crucial for the binding affinity with ALG-2.	Proline	43-50	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	189-194
14986171-2	2004	ALDH4 is a mitochondrial-matrix NAD+-dependent enzyme catalyzing the second step of the proline degradation pathway.	Proline	88-95	aldehyde dehydrogenase 3 family member B1	Homo sapiens	0-5
14675164-0	2004	Role of proline residues in the expression and function of the human noradrenaline transporter.	Proline	8-15	solute carrier family 6 member 2	Homo sapiens	69-94
14675164-1	2004	The aim was to investigate the roles of proline residues in extracellular loop 2 (P172, P183, P188 and P209) and transmembrane domains 2, 5, 11 and 12 (P108, P270, P526, P551, P552 and P570) in determining noradrenaline transporter (NET) expression and function.	Proline	40-47	solute carrier family 6 member 2	Homo sapiens	206-231
14525953-0	2004	Position of Pro and Ser near Glu7.32 in the extracellular loop 3 of mammalian and nonmammalian gonadotropin-releasing hormone (GnRH) receptors is a critical determinant for differential ligand selectivity for mammalian GnRH and chicken GnRH-II.	Proline	12-15	gonadotropin releasing hormone 1	Homo sapiens	95-125
14998162-5	2004	Essentially, all of the amide bond cleavages associated with the +10 charge state of fully guanidinated ubiquitin were observed to occur C-terminal to aspartic acid residues, unlike the dissociation behavior of the +10 ion of the unmodified protein, where competing cleavage N-terminal to proline and nonspecific amide bond cleavages were also observed.	Proline	289-296	ubiquitin	Bos taurus	104-113
15002667-3	2004	Like Wir1 proteins, it consists of a hydrophobic N-terminal half and a hydrophilic C-terminal half relatively rich in glycine and proline.	Proline	130-137	WIR1	Triticum aestivum	5-9
14525953-0	2004	Position of Pro and Ser near Glu7.32 in the extracellular loop 3 of mammalian and nonmammalian gonadotropin-releasing hormone (GnRH) receptors is a critical determinant for differential ligand selectivity for mammalian GnRH and chicken GnRH-II.	Proline	12-15	gonadotropin releasing hormone 1	Homo sapiens	127-131
14525953-0	2004	Position of Pro and Ser near Glu7.32 in the extracellular loop 3 of mammalian and nonmammalian gonadotropin-releasing hormone (GnRH) receptors is a critical determinant for differential ligand selectivity for mammalian GnRH and chicken GnRH-II.	Proline	12-15	gonadotropin releasing hormone 1	Homo sapiens	219-223
14525953-0	2004	Position of Pro and Ser near Glu7.32 in the extracellular loop 3 of mammalian and nonmammalian gonadotropin-releasing hormone (GnRH) receptors is a critical determinant for differential ligand selectivity for mammalian GnRH and chicken GnRH-II.	Proline	12-15	mitochondrial ribosomal protein S26	Gallus gallus	236-243
14525953-5	2004	Either placing Pro before Glu7.32 or placing Ser after Glu7.32 significantly decreased the sensitivity and/or efficacy for mGnRH, but slightly increased that for cGnRH-II in several mutant receptors.	Proline	15-18	gonadotropin releasing hormone 1	Mus musculus	123-128
15263792-7	2004	The proline form of p53 gene codon 72 was significantly higher than the arginine form, with an odds ratio of 2.606 (95% CI = 1.052-6.455).	Proline	4-11	tumor protein p53	Homo sapiens	20-23
15207362-1	2004	The brain substrates involved in the pharmacological effects of neuropeptide FF (NPFF, Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2) including interactions with opioid systems, were investigated with the [14C]-2-deoxyglucose ([14C]-2-DG) autoradiography technique in mouse.	Proline	103-106	neuropeptide FF-amide peptide precursor	Mus musculus	64-79
15651660-2	2004	The functional oligonucleotide polymorphism of the p53 gene causes the substitution of arginine (Arg) for praline (Pro) in the codon 72.	Proline	115-118	tumor protein p53	Homo sapiens	51-54
15263792-11	2004	The proline form of p53 gene codon 72 might be a more significant risk factor for the development of metastasis than the arginine form.	Proline	4-11	tumor protein p53	Homo sapiens	20-23
14651991-0	2003	Isolation and characterisation of proline/arginine-rich cathelicidin peptides from ovine neutrophils.	Proline	34-41	cathelicidin-2	Ovis aries	56-68
14551197-3	2003	This interaction was direct and was mediated partly through the proline-rich region of C3G.	Proline	64-71	Rap guanine nucleotide exchange factor 1	Homo sapiens	87-90
14555844-1	2004	OBJECTIVES: Ankyrin-repeated protein with PEST and a proline-rich region (ARPP) is a recently identified protein with 4 ankyrin-repeated motifs in its central portion.	Proline	53-60	ankyrin repeat domain 2	Homo sapiens	74-78
14651991-3	2003	In this work numerous proline/arginine-rich cathelicidin peptides were purified, including the originally predicted OaBac5 and another OaBac5 variant.	Proline	22-29	cathelicidin-2	Ovis aries	44-56
14651991-3	2003	In this work numerous proline/arginine-rich cathelicidin peptides were purified, including the originally predicted OaBac5 and another OaBac5 variant.	Proline	22-29	cathelicidin-2	Ovis aries	135-141
14691143-8	2003	Interestingly, the adhesion-mediating and cytoskeleton-disrupting effects were localized to the same NH2-terminal proline-rich region of LTBP-2.	Proline	114-121	latent transforming growth factor beta binding protein 2	Homo sapiens	137-143
14530287-10	2003	Further analysis demonstrated that proline-rich regions of RARP1 are the functional regions regulated for suppression of activator protein1 transactivation.	Proline	35-42	amyloid beta precursor protein binding family B member 1 interacting protein	Homo sapiens	59-64
14506259-8	2003	When linked to a suboptimal phosphorylation site sequence (Lys+2 --&gt; Pro) the Cy motif increases catalytic efficiency (kcat/Km) by increasing affinity without affecting turnover (kcat).	Proline	72-75	aminoadipate-semialdehyde dehydrogenase	Homo sapiens	59-64
14530287-10	2003	Further analysis demonstrated that proline-rich regions of RARP1 are the functional regions regulated for suppression of activator protein1 transactivation.	Proline	35-42	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	121-139
13678420-0	2003	Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage.	Proline	40-48	F2R like thrombin or trypsin receptor 3	Homo sapiens	0-29
13678420-0	2003	Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage.	Proline	40-48	coagulation factor II, thrombin	Homo sapiens	84-92
13678420-9	2003	Thus, to compensate for the lack of exosite I binding, PAR4 utilizes proline residues in its P(4)-P(1) sequence to provide high-affinity interactions with the active site and an anionic cluster to slow dissociation from the cationic thrombin.	Proline	69-76	F2R like thrombin or trypsin receptor 3	Homo sapiens	55-59
13678420-9	2003	Thus, to compensate for the lack of exosite I binding, PAR4 utilizes proline residues in its P(4)-P(1) sequence to provide high-affinity interactions with the active site and an anionic cluster to slow dissociation from the cationic thrombin.	Proline	69-76	coagulation factor II, thrombin	Homo sapiens	233-241
14596813-1	2003	The polymorphism at position 25 of the gene encoding transforming growth factor-beta1 (TGF-beta1), which changes the amino acid sequence of the signal peptide sequence (arginine to proline), is causing a variation in TGF-beta1 production.	Proline	181-188	transforming growth factor beta 1	Homo sapiens	53-85
14656520-0	2003	Pharmacokinetics of glycine-proline-glutamate, the N-terminal tripeptide of insulin-like growth factor-1, in rats.	Proline	28-35	insulin-like growth factor 1	Rattus norvegicus	76-104
14656102-1	2003	N-Tritylprolinal (prepared in four steps from l-proline) shows a very high Felkin diastereoselectivity in its reaction with various nucleophiles, leading to a straightforward and highly stereoselective access to syn-proline-derived amino alcohols.	Proline	46-55	synemin	Homo sapiens	212-215
13679373-6	2003	The final structure of the IL-1 receptor accessory protein TIR domain suggests the conserved regions box 1 and 2, including Pro-446, as well as box 3 within the C-terminal alpha-helix as possible protein-protein interaction sites due to their exposure and their electrostatic potential.	Proline	124-127	interleukin 1 alpha	Homo sapiens	27-31
13679373-7	2003	Pro-446, corresponding to the Pro/His mutation in dominant negative TLR4, is located in the third loop at the outmost edge of the TIR domain and does not play any structural role.	Proline	0-3	toll like receptor 4	Homo sapiens	68-72
13679373-7	2003	Pro-446, corresponding to the Pro/His mutation in dominant negative TLR4, is located in the third loop at the outmost edge of the TIR domain and does not play any structural role.	Proline	30-33	toll like receptor 4	Homo sapiens	68-72
13679373-8	2003	Inhibition of IL-1 responsiveness seen after substitution of Pro-446 by charged amino acids is due to the loss of an interaction site for other TIR domains.	Proline	61-64	interleukin 1 alpha	Homo sapiens	14-18
14601047-7	2003	The inhibitory effect of ASC after taking it with proline was less in the high-risk area.	Proline	50-57	PYD and CARD domain containing	Homo sapiens	25-28
14596813-1	2003	The polymorphism at position 25 of the gene encoding transforming growth factor-beta1 (TGF-beta1), which changes the amino acid sequence of the signal peptide sequence (arginine to proline), is causing a variation in TGF-beta1 production.	Proline	181-188	transforming growth factor beta 1	Homo sapiens	87-96
14596813-1	2003	The polymorphism at position 25 of the gene encoding transforming growth factor-beta1 (TGF-beta1), which changes the amino acid sequence of the signal peptide sequence (arginine to proline), is causing a variation in TGF-beta1 production.	Proline	181-188	transforming growth factor beta 1	Homo sapiens	217-226
14654359-6	2003	Unlike wild-type hirudin, the variant comprising Pro(50)- ...-His(56)-Asp(57)- ...-Pro(62)-Pro(63)-His(64) is completely resistant to pepsin and chymotrypsin cleavage; however, this is at the expense of thrombin inhibition activity where there is a 100-fold increase in the IC50 value.	Proline	49-52	coagulation factor II, thrombin	Homo sapiens	203-211
14643929-6	2003	Residues Phe 174, Asn 182, Ser 191, Leu 196, Pro 199, Asn 266, Tyr 269, Asp 271 and Gln 275 appear to be additionally important elements of the active site but their conversion into corresponding Erg3p residues did not lead to a gain in desaturase activity.	Proline	45-48	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	196-201
14628291-7	2003	A proline-to-leucine amino acid exchange is present in affected members of one family with MRX.	Proline	2-9	discs large MAGUK scaffold protein 3	Homo sapiens	91-94
15028620-1	2003	IRAS, a putative clone of the I(1)-imidazoline receptor, possesses a proline-rich region (PRR) motif, which might interact with SH3 regions on tyrosine kinases, and an integrin-binding motif.	Proline	69-76	nischarin	Homo sapiens	0-4
14624766-7	2003	In the presence of ECM, IGFBP-2/IGF-II was as effective as IGF-II alone in stimulating [3H]thymidine and [3H]proline incorporation and in inhibiting apoptosis in cultured human osteoblasts.	Proline	109-116	insulin like growth factor binding protein 2	Homo sapiens	24-31
14624766-7	2003	In the presence of ECM, IGFBP-2/IGF-II was as effective as IGF-II alone in stimulating [3H]thymidine and [3H]proline incorporation and in inhibiting apoptosis in cultured human osteoblasts.	Proline	109-116	insulin like growth factor 2	Homo sapiens	32-38
14624766-7	2003	In the presence of ECM, IGFBP-2/IGF-II was as effective as IGF-II alone in stimulating [3H]thymidine and [3H]proline incorporation and in inhibiting apoptosis in cultured human osteoblasts.	Proline	109-116	insulin like growth factor 2	Homo sapiens	59-65
14645512-8	2003	The aberrant nuclear function of eIF4E is due to abnormally large eIF4E bodies and the loss of regulation by the proline-rich homeodomain PRH.	Proline	113-120	eukaryotic translation initiation factor 4E	Homo sapiens	33-38
14645512-8	2003	The aberrant nuclear function of eIF4E is due to abnormally large eIF4E bodies and the loss of regulation by the proline-rich homeodomain PRH.	Proline	113-120	hematopoietically expressed homeobox	Homo sapiens	138-141
14719796-5	2003	We generated three novel Glu9-substituted GLP-1 analogues, (Pro9)GLP-1, (Phe9)GLP-1 and (Tyr9)GLP-1 and show for the first time that Glu9 of GLP-1 is important in DPP IV degradation, since replacing this amino acid, particularly with proline, substantially reduced susceptibility to degradation.	Proline	234-241	glucagon	Mus musculus	42-47
14750503-5	2003	The inhibitory activity against thrombin or botrocetin is mainly linked to Arg-Arg-Pro-Phe or Trp-Ile-Arg-Arg-Pro, respectively, among nine amino acids.	Proline	83-86	coagulation factor II, thrombin	Homo sapiens	32-40
14612423-0	2003	The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53.	Proline	4-11	tumor protein p53	Homo sapiens	29-32
14612423-0	2003	The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53.	Proline	4-11	E1A binding protein p300	Homo sapiens	83-87
14612423-0	2003	The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53.	Proline	4-11	tumor protein p53	Homo sapiens	145-148
14612423-4	2003	The enriched p300-binding peptides contained a proline repeat (PXXP/PXPXP) motif, and five proline repeat motifs actually reside within the p53 transactivation domain, suggesting that this region of p53 may harbor the second p300 contact site.	Proline	47-54	E1A binding protein p300	Homo sapiens	13-17
14612423-5	2003	p300 binds in vitro to PXXP-containing peptides derived from the proline repeat domain, and PXXP-containing peptides inhibit sequence-specific DNA-dependent acetylation of p53, indicating that p300 docking to both the LXXLL and contiguous PXXP motif in p53 is required for p53 acetylation.	Proline	65-72	E1A binding protein p300	Homo sapiens	0-4
14612423-5	2003	p300 binds in vitro to PXXP-containing peptides derived from the proline repeat domain, and PXXP-containing peptides inhibit sequence-specific DNA-dependent acetylation of p53, indicating that p300 docking to both the LXXLL and contiguous PXXP motif in p53 is required for p53 acetylation.	Proline	65-72	tumor protein p53	Homo sapiens	172-175
14612423-5	2003	p300 binds in vitro to PXXP-containing peptides derived from the proline repeat domain, and PXXP-containing peptides inhibit sequence-specific DNA-dependent acetylation of p53, indicating that p300 docking to both the LXXLL and contiguous PXXP motif in p53 is required for p53 acetylation.	Proline	65-72	E1A binding protein p300	Homo sapiens	193-197
14612423-5	2003	p300 binds in vitro to PXXP-containing peptides derived from the proline repeat domain, and PXXP-containing peptides inhibit sequence-specific DNA-dependent acetylation of p53, indicating that p300 docking to both the LXXLL and contiguous PXXP motif in p53 is required for p53 acetylation.	Proline	65-72	tumor protein p53	Homo sapiens	253-256
14612423-5	2003	p300 binds in vitro to PXXP-containing peptides derived from the proline repeat domain, and PXXP-containing peptides inhibit sequence-specific DNA-dependent acetylation of p53, indicating that p300 docking to both the LXXLL and contiguous PXXP motif in p53 is required for p53 acetylation.	Proline	65-72	tumor protein p53	Homo sapiens	253-256
14612423-6	2003	Deletion of the proline repeat motif of p53 prevents DNA-dependent acetylation of p53 by occluding p300 from the p53-DNA complex.	Proline	16-23	tumor protein p53	Homo sapiens	40-43
14612423-6	2003	Deletion of the proline repeat motif of p53 prevents DNA-dependent acetylation of p53 by occluding p300 from the p53-DNA complex.	Proline	16-23	tumor protein p53	Homo sapiens	82-85
14612423-6	2003	Deletion of the proline repeat motif of p53 prevents DNA-dependent acetylation of p53 by occluding p300 from the p53-DNA complex.	Proline	16-23	E1A binding protein p300	Homo sapiens	99-103
14612423-6	2003	Deletion of the proline repeat motif of p53 prevents DNA-dependent acetylation of p53 by occluding p300 from the p53-DNA complex.	Proline	16-23	tumor protein p53	Homo sapiens	82-85
14654359-6	2003	Unlike wild-type hirudin, the variant comprising Pro(50)- ...-His(56)-Asp(57)- ...-Pro(62)-Pro(63)-His(64) is completely resistant to pepsin and chymotrypsin cleavage; however, this is at the expense of thrombin inhibition activity where there is a 100-fold increase in the IC50 value.	Proline	83-86	coagulation factor II, thrombin	Homo sapiens	203-211
14691750-5	2003	Pin1 possesses a WW domain which specifically recognizes pSer-Pro and pThr-Pro motifs in which the first amino acid is phosphorylated.	Proline	62-65	peptidylprolyl isomerase ESS1	Saccharomyces cerevisiae S288C	0-4
14654359-6	2003	Unlike wild-type hirudin, the variant comprising Pro(50)- ...-His(56)-Asp(57)- ...-Pro(62)-Pro(63)-His(64) is completely resistant to pepsin and chymotrypsin cleavage; however, this is at the expense of thrombin inhibition activity where there is a 100-fold increase in the IC50 value.	Proline	83-86	coagulation factor II, thrombin	Homo sapiens	203-211
14691750-5	2003	Pin1 possesses a WW domain which specifically recognizes pSer-Pro and pThr-Pro motifs in which the first amino acid is phosphorylated.	Proline	75-78	peptidylprolyl isomerase ESS1	Saccharomyces cerevisiae S288C	0-4
14654359-7	2003	The frequent replacement of wild-type amino acids by proline at major protease cleavage sites indicates that at least pepsin- and chymotrypsin-like enzymes may exhibit a (conformational) specificity concerning the P1 and P2 positions.	Proline	53-60	crystallin gamma F, pseudogene	Homo sapiens	214-223
14691750-5	2003	Pin1 possesses a WW domain which specifically recognizes pSer-Pro and pThr-Pro motifs in which the first amino acid is phosphorylated.	Proline	75-78	parathyroid hormone 1 receptor	Homo sapiens	70-74
14612423-7	2003	Sequence-specific DNA places an absolute requirement for the proline repeat domain to drive p53 acetylation in vivo.	Proline	61-68	tumor protein p53	Homo sapiens	92-95
14612423-8	2003	Chromatin immunoprecipitation was used to show that the proline repeat deletion mutant p53 is bound to the p21 promoter in vivo, but it is not acetylated, indicating that proline-directed acetylation of p53 is a post-DNA binding event.	Proline	56-63	tumor protein p53	Homo sapiens	87-90
14623256-2	2003	To gain insight into the sequences directing this divergent phenotype, we investigated a panel of H-Ras/R-Ras chimeras and found that sequences in the R-Ras hypervariable C-terminal region including amino acids 175-203 are required for the R-Ras ability to increase integrin activation in CHO cells; however, the proline-rich site in this region, previously reported to bind the adaptor protein Nck, was not essential for this effect.	Proline	313-320	GTPase HRas	Cricetulus griseus	98-103
14612423-8	2003	Chromatin immunoprecipitation was used to show that the proline repeat deletion mutant p53 is bound to the p21 promoter in vivo, but it is not acetylated, indicating that proline-directed acetylation of p53 is a post-DNA binding event.	Proline	56-63	H3 histone pseudogene 16	Homo sapiens	107-110
14612423-8	2003	Chromatin immunoprecipitation was used to show that the proline repeat deletion mutant p53 is bound to the p21 promoter in vivo, but it is not acetylated, indicating that proline-directed acetylation of p53 is a post-DNA binding event.	Proline	56-63	tumor protein p53	Homo sapiens	203-206
14612423-8	2003	Chromatin immunoprecipitation was used to show that the proline repeat deletion mutant p53 is bound to the p21 promoter in vivo, but it is not acetylated, indicating that proline-directed acetylation of p53 is a post-DNA binding event.	Proline	171-178	tumor protein p53	Homo sapiens	87-90
14612423-8	2003	Chromatin immunoprecipitation was used to show that the proline repeat deletion mutant p53 is bound to the p21 promoter in vivo, but it is not acetylated, indicating that proline-directed acetylation of p53 is a post-DNA binding event.	Proline	171-178	H3 histone pseudogene 16	Homo sapiens	107-110
14612423-8	2003	Chromatin immunoprecipitation was used to show that the proline repeat deletion mutant p53 is bound to the p21 promoter in vivo, but it is not acetylated, indicating that proline-directed acetylation of p53 is a post-DNA binding event.	Proline	171-178	tumor protein p53	Homo sapiens	203-206
14612423-9	2003	The PXXP repeat expands the basic interface of a p300-targeted transactivation domain, and proline-directed acetylation of p53 at promoters indicates that p300-mediated acetylation can be highly constrained by substrate conformation in vivo.	Proline	91-98	tumor protein p53	Homo sapiens	123-126
14612423-9	2003	The PXXP repeat expands the basic interface of a p300-targeted transactivation domain, and proline-directed acetylation of p53 at promoters indicates that p300-mediated acetylation can be highly constrained by substrate conformation in vivo.	Proline	91-98	E1A binding protein p300	Homo sapiens	155-159
13129931-6	2003	We mutated Pro-190 of the yeast Sdh2p subunit to Gln (P190Q) and recreated the C. elegans mev-1 mutation by converting Ser-94 in the Sdh3p subunit into a glutamate residue (S94E).	Proline	11-14	succinate dehydrogenase iron-sulfur protein subunit SDH2	Saccharomyces cerevisiae S288C	32-37
13129931-6	2003	We mutated Pro-190 of the yeast Sdh2p subunit to Gln (P190Q) and recreated the C. elegans mev-1 mutation by converting Ser-94 in the Sdh3p subunit into a glutamate residue (S94E).	Proline	11-14	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	90-95
14641934-14	2003	These patients also had FHH caused by a novel, sporadic mutation in the CASR gene (518T&gt;C) leading to an amino acid exchange (leucine-&gt;proline) in the extracellular domain of the CASR protein.	Proline	141-148	calcium sensing receptor	Homo sapiens	24-27
14641934-14	2003	These patients also had FHH caused by a novel, sporadic mutation in the CASR gene (518T&gt;C) leading to an amino acid exchange (leucine-&gt;proline) in the extracellular domain of the CASR protein.	Proline	141-148	calcium sensing receptor	Homo sapiens	72-76
14641934-14	2003	These patients also had FHH caused by a novel, sporadic mutation in the CASR gene (518T&gt;C) leading to an amino acid exchange (leucine-&gt;proline) in the extracellular domain of the CASR protein.	Proline	141-148	calcium sensing receptor	Homo sapiens	185-189
14506255-11	2003	ACK1 interacts most strongly with the SH3 domains of Src family kinases (Src or Hck) via its C-terminal proline-rich domain.	Proline	104-111	tyrosine kinase non receptor 2	Homo sapiens	0-4
14506255-11	2003	ACK1 interacts most strongly with the SH3 domains of Src family kinases (Src or Hck) via its C-terminal proline-rich domain.	Proline	104-111	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
14623869-4	2003	Cdk5 phosphorylated the proline-rich domain of both amphiphysin I and dynamin I in vitro and in vivo.	Proline	24-31	cyclin-dependent kinase 5	Mus musculus	0-4
14622005-3	2003	In contrast, in mammalian mitochondrial EF-Tu"s, the corresponding position is occupied by a conserved proline residue.	Proline	103-110	Tu translation elongation factor, mitochondrial	Homo sapiens	40-45
14607332-2	2003	The gene for TGF-beta1, TGFB1, carries a common T/C variation of nucleotide 29, resulting in a leucine (L) to proline (P) polymorphism at codon 10 (TGFB1 L10P).	Proline	110-117	transforming growth factor beta 1	Homo sapiens	13-22
14607332-2	2003	The gene for TGF-beta1, TGFB1, carries a common T/C variation of nucleotide 29, resulting in a leucine (L) to proline (P) polymorphism at codon 10 (TGFB1 L10P).	Proline	110-117	transforming growth factor beta 1	Homo sapiens	24-29
14607332-2	2003	The gene for TGF-beta1, TGFB1, carries a common T/C variation of nucleotide 29, resulting in a leucine (L) to proline (P) polymorphism at codon 10 (TGFB1 L10P).	Proline	110-117	transforming growth factor beta 1	Homo sapiens	148-153
12958308-0	2003	Amyloid fibril formation in the context of full-length protein: effects of proline mutations on the amyloid fibril formation of beta2-microglobulin.	Proline	75-82	beta-2-microglobulin	Homo sapiens	128-147
12952955-9	2003	Altogether, our results identify a proline- and glutamine-rich linker located between the RRMs and the PABC domain as being strictly required for PABP/PABP interaction, cooperative binding to poly(A) and enhanced translational repression of reporter mRNAs in vitro and in vivo.	Proline	35-42	poly(A) binding protein cytoplasmic 1	Homo sapiens	146-150
14627652-6	2003	To test this, sciatic nerves of Trembler J (TrJ) neuropathy mice carrying a leucine-to-proline mutation in PMP22 were studied.	Proline	87-94	peripheral myelin protein 22	Mus musculus	107-112
12952955-9	2003	Altogether, our results identify a proline- and glutamine-rich linker located between the RRMs and the PABC domain as being strictly required for PABP/PABP interaction, cooperative binding to poly(A) and enhanced translational repression of reporter mRNAs in vitro and in vivo.	Proline	35-42	poly(A) binding protein cytoplasmic 1	Homo sapiens	151-155
14609956-5	2003	A strong intrinsic transactivation domain was identified in the C-terminal, proline-rich region of hZimp10.	Proline	76-83	zinc finger MIZ-type containing 1	Homo sapiens	99-106
12966092-11	2003	Interestingly, PPARalpha and gamma agonists caused rapid activation of proline-rich tyrosine kinase or Pyk2; Pyk2 as well as p38 phosphorylation was reduced by intracellular Ca2+ chelation without an observable effect on EGFR and Erk activation, suggesting a possible role for Pyk2 as an upstream activator of p38.	Proline	71-78	peroxisome proliferator activated receptor alpha	Homo sapiens	15-24
12966092-11	2003	Interestingly, PPARalpha and gamma agonists caused rapid activation of proline-rich tyrosine kinase or Pyk2; Pyk2 as well as p38 phosphorylation was reduced by intracellular Ca2+ chelation without an observable effect on EGFR and Erk activation, suggesting a possible role for Pyk2 as an upstream activator of p38.	Proline	71-78	protein tyrosine kinase 2 beta	Homo sapiens	109-113
12966092-11	2003	Interestingly, PPARalpha and gamma agonists caused rapid activation of proline-rich tyrosine kinase or Pyk2; Pyk2 as well as p38 phosphorylation was reduced by intracellular Ca2+ chelation without an observable effect on EGFR and Erk activation, suggesting a possible role for Pyk2 as an upstream activator of p38.	Proline	71-78	epidermal growth factor receptor	Homo sapiens	221-225
12966092-11	2003	Interestingly, PPARalpha and gamma agonists caused rapid activation of proline-rich tyrosine kinase or Pyk2; Pyk2 as well as p38 phosphorylation was reduced by intracellular Ca2+ chelation without an observable effect on EGFR and Erk activation, suggesting a possible role for Pyk2 as an upstream activator of p38.	Proline	71-78	mitogen-activated protein kinase 1	Homo sapiens	230-233
12966092-11	2003	Interestingly, PPARalpha and gamma agonists caused rapid activation of proline-rich tyrosine kinase or Pyk2; Pyk2 as well as p38 phosphorylation was reduced by intracellular Ca2+ chelation without an observable effect on EGFR and Erk activation, suggesting a possible role for Pyk2 as an upstream activator of p38.	Proline	71-78	protein tyrosine kinase 2 beta	Homo sapiens	109-113
12966092-11	2003	Interestingly, PPARalpha and gamma agonists caused rapid activation of proline-rich tyrosine kinase or Pyk2; Pyk2 as well as p38 phosphorylation was reduced by intracellular Ca2+ chelation without an observable effect on EGFR and Erk activation, suggesting a possible role for Pyk2 as an upstream activator of p38.	Proline	71-78	mitogen-activated protein kinase 1	Homo sapiens	310-313
14556798-2	2003	We have extensively explored the therapeutic utility of FKBP12 ligands based on analogues of proline and pipecolic acid.	Proline	93-100	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	56-62
12944407-0	2003	Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1.	Proline	83-90	Rho GTPase activating protein 1	Homo sapiens	52-60
12944407-0	2003	Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1.	Proline	83-90	Rho GTPase activating protein 8	Homo sapiens	177-183
12944407-3	2003	We have identified a novel RhoGAP, BPGAP1 (for BNIP-2 and Cdc42GAP Homology (BCH) domain-containing, Proline-rich and Cdc42GAP-like protein subtype-1), that is ubiquitously expressed and shares 54% sequence identity to Cdc42GAP/p50RhoGAP.	Proline	101-108	Rho GTPase activating protein 8	Homo sapiens	35-41
12944407-3	2003	We have identified a novel RhoGAP, BPGAP1 (for BNIP-2 and Cdc42GAP Homology (BCH) domain-containing, Proline-rich and Cdc42GAP-like protein subtype-1), that is ubiquitously expressed and shares 54% sequence identity to Cdc42GAP/p50RhoGAP.	Proline	101-108	Rho GTPase activating protein 1	Homo sapiens	228-237
14506127-3	2003	The aim of this study was to determine whether the human PPAR gamma proline to alanine substitution polymorphism (Pro12Ala) modifies the association between dietary fat and adiposity and plasma lipids.	Proline	68-75	peroxisome proliferator activated receptor gamma	Homo sapiens	57-67
12952982-4	2003	An analysis of interactions between ADAM12 and PACSIN3 using glutathione S-transferase fusion protein revealed that a proline-rich region (amino acid residues 829-840) of ADAM12 was required to bind PACSIN3.	Proline	118-125	ADAM metallopeptidase domain 12	Homo sapiens	36-42
12952982-4	2003	An analysis of interactions between ADAM12 and PACSIN3 using glutathione S-transferase fusion protein revealed that a proline-rich region (amino acid residues 829-840) of ADAM12 was required to bind PACSIN3.	Proline	118-125	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	47-54
12952982-4	2003	An analysis of interactions between ADAM12 and PACSIN3 using glutathione S-transferase fusion protein revealed that a proline-rich region (amino acid residues 829-840) of ADAM12 was required to bind PACSIN3.	Proline	118-125	ADAM metallopeptidase domain 12	Homo sapiens	171-177
12952982-4	2003	An analysis of interactions between ADAM12 and PACSIN3 using glutathione S-transferase fusion protein revealed that a proline-rich region (amino acid residues 829-840) of ADAM12 was required to bind PACSIN3.	Proline	118-125	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	199-206
14595024-4	2003	We now show that proline serine threonine phosphatase-interacting protein [PSTPIP1, or CD2-binding protein 1 (CD2BP1)], a tyrosine-phosphorylated protein involved in cytoskeletal organization, also interacts with pyrin.	Proline	17-24	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	75-82
14595024-4	2003	We now show that proline serine threonine phosphatase-interacting protein [PSTPIP1, or CD2-binding protein 1 (CD2BP1)], a tyrosine-phosphorylated protein involved in cytoskeletal organization, also interacts with pyrin.	Proline	17-24	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	87-108
14595024-4	2003	We now show that proline serine threonine phosphatase-interacting protein [PSTPIP1, or CD2-binding protein 1 (CD2BP1)], a tyrosine-phosphorylated protein involved in cytoskeletal organization, also interacts with pyrin.	Proline	17-24	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	110-116
14595024-4	2003	We now show that proline serine threonine phosphatase-interacting protein [PSTPIP1, or CD2-binding protein 1 (CD2BP1)], a tyrosine-phosphorylated protein involved in cytoskeletal organization, also interacts with pyrin.	Proline	17-24	MEFV innate immuity regulator, pyrin	Homo sapiens	213-218
14606895-1	2003	The concentration dependence of the pressure- and temperature-induced cloud point transition (Pc and Tc, respectively) of aqueous solutions of an elastin-like polypeptide with a repeating pentapeptide Val-Pro-Gly-Ile-Gly sequence (MGLDGSMG(VPGIG)40VPLE) was investigated by using apparent light scattering, differential scanning calorimetry, and circular dichroism methods.	Proline	205-208	elastin	Homo sapiens	146-153
14705781-1	2003	Aminopeptidase P (APP; EC 3.4.11.9) is a proline-specific peptidase hydrolyzing N-terminal Xaa-Pro peptide bonds.	Proline	41-48	amyloid beta precursor protein	Rattus norvegicus	0-16
14552797-0	2003	Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands.	Proline	44-51	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	52-58
14552797-1	2003	As part of our ongoing program to explore novel structural classes of FKBP12 ligands, we herein wish to report a new class of FKBP12 ligands containing chiral bicyclic proline analogues.	Proline	168-175	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	70-76
14552797-1	2003	As part of our ongoing program to explore novel structural classes of FKBP12 ligands, we herein wish to report a new class of FKBP12 ligands containing chiral bicyclic proline analogues.	Proline	168-175	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	126-132
14602584-2	2003	A freeze-tolerant mutant with L-proline accumulation was recently shown to carry an allele of the PRO1 gene encoding gamma-glutamyl kinase, which resulted in a single amino acid substitution (Asp154Asn).	Proline	30-39	glutamate 5-kinase	Saccharomyces cerevisiae S288C	98-102
14504459-0	2003	Getting in the ring: proline-directed substrate specificity in the cell cycle proteins Cdc14 and CDK2-cyclinA3.	Proline	21-28	cell division cycle 14A	Homo sapiens	87-92
14617022-3	2003	The LBR gene (LBR) was also sequenced from a single English man with Pelger-Huet anomaly and a heterozygous C-->G mutation was found in codon 569 of exon 14, predicted to cause a proline-->arginine.	Proline	179-186	lamin B receptor	Homo sapiens	4-7
14617022-3	2003	The LBR gene (LBR) was also sequenced from a single English man with Pelger-Huet anomaly and a heterozygous C-->G mutation was found in codon 569 of exon 14, predicted to cause a proline-->arginine.	Proline	179-186	lamin B receptor	Homo sapiens	14-17
14504459-0	2003	Getting in the ring: proline-directed substrate specificity in the cell cycle proteins Cdc14 and CDK2-cyclinA3.	Proline	21-28	cyclin dependent kinase 2	Homo sapiens	97-101
14572862-2	2003	Conjugation of melphalan (Mel) with proline (Pro) through imido-bond resulted in formation of a good substrate for prolidase.	Proline	36-43	peptidase D	Homo sapiens	115-124
14572862-0	2003	Proline analogue of melphalan as a prodrug susceptible to the action of prolidase in breast cancer MDA-MB 231 cells.	Proline	0-7	peptidase D	Homo sapiens	72-81
14572862-1	2003	Proline analogue of melphalan (Mel-pro) was synthesized as a prodrug susceptible to the action of ubiquitously distributed, cytosolic imidodipeptidase-prolidase [E.C.3.4.13.9].	Proline	0-7	peptidase D	Homo sapiens	151-160
14572862-2	2003	Conjugation of melphalan (Mel) with proline (Pro) through imido-bond resulted in formation of a good substrate for prolidase.	Proline	45-48	peptidase D	Homo sapiens	115-124
14686752-4	2003	Direct sequencing analysis revealed a novel missense mutation at codon 342 in exon 7 causing an amino acid change from alanine to proline (A342P) of the MEN1 gene.	Proline	130-137	menin 1	Homo sapiens	153-157
14572862-3	2003	Cytosolic location of prolidase in neoplastic cell suggests that proline analogue of melphalan (Mel-pro) may serve as a prolidase convertible prodrug.	Proline	65-72	peptidase D	Homo sapiens	22-31
14572862-3	2003	Cytosolic location of prolidase in neoplastic cell suggests that proline analogue of melphalan (Mel-pro) may serve as a prolidase convertible prodrug.	Proline	65-72	peptidase D	Homo sapiens	120-129
12853460-7	2003	Second, trichohyalin serves as a cross-bridging reinforcement protein of the cornified cell envelope of the inner root sheath cells by becoming cross-linked to several known or novel barrier proteins, including involucrin, small proline-rich proteins, repetin, and epiplakin.	Proline	229-236	trichohyalin	Mus musculus	8-20
14615027-3	2003	The Y1/Y4/Y5 agonist Leu(31), Pro(34)-NPY increased [35S]GTPgammaS binding in several brain areas with a regional distribution consistent with that produced when labeling adjacent sections with [125I]-Leu(31), Pro(34)-PYY.	Proline	30-33	neuropeptide Y	Rattus norvegicus	38-41
14615027-3	2003	The Y1/Y4/Y5 agonist Leu(31), Pro(34)-NPY increased [35S]GTPgammaS binding in several brain areas with a regional distribution consistent with that produced when labeling adjacent sections with [125I]-Leu(31), Pro(34)-PYY.	Proline	30-33	peptide YY	Rattus norvegicus	218-221
12881522-2	2003	Our recent investigation of the conformational heterogeneity of the proline residues in the N terminus of Vpr suggested a functional interaction between Vpr and a host peptidylprolyl cis/trans isomerase (PPIase) that might regulate the cis/trans interconversion of the imidic bond within the conserved proline residues of Vpr in vivo.	Proline	68-75	peptidylprolyl isomerase like 1	Homo sapiens	168-202
12881522-2	2003	Our recent investigation of the conformational heterogeneity of the proline residues in the N terminus of Vpr suggested a functional interaction between Vpr and a host peptidylprolyl cis/trans isomerase (PPIase) that might regulate the cis/trans interconversion of the imidic bond within the conserved proline residues of Vpr in vivo.	Proline	68-75	peptidylprolyl isomerase like 1	Homo sapiens	204-210
12881522-2	2003	Our recent investigation of the conformational heterogeneity of the proline residues in the N terminus of Vpr suggested a functional interaction between Vpr and a host peptidylprolyl cis/trans isomerase (PPIase) that might regulate the cis/trans interconversion of the imidic bond within the conserved proline residues of Vpr in vivo.	Proline	302-309	peptidylprolyl isomerase like 1	Homo sapiens	168-202
12881522-2	2003	Our recent investigation of the conformational heterogeneity of the proline residues in the N terminus of Vpr suggested a functional interaction between Vpr and a host peptidylprolyl cis/trans isomerase (PPIase) that might regulate the cis/trans interconversion of the imidic bond within the conserved proline residues of Vpr in vivo.	Proline	302-309	peptidylprolyl isomerase like 1	Homo sapiens	204-210
14572643-4	2003	Whereas GCMb/Gcm-2 contained a classical bipartite NLS, nuclear localization of GCMa/Gcm-1 was mediated by two regions without resemblance to known NLS, one corresponding to the amino-terminal part of the GCM domain, the second defined as a tyrosine-and-proline-rich carboxy-terminal region.	Proline	254-261	glial cells missing transcription factor 1	Homo sapiens	80-84
14529717-7	2003	Expression of a mutant amphiphysin harboring two amino acid substitutions in the SH3 domain, and therefore unable to bind proline-containing motifs, induces an accumulation of large intracellular aggregates including amphiphysin, clathrin, AP-2, and other endocytic proteins, as well as a concomitant block of transferrin endocytosis.	Proline	122-129	amphiphysin	Homo sapiens	23-34
14728886-14	2003	ACE activity of kidney was significantly (P &lt; 0.01) increased in GH-treated AN rats [(28.1 +/- 4.1) U/mg pro] and GH-treated AN rats plus irbesartan [(27.6 +/- 3.4) U/mg pro] compared with that in AN rats [(14.6 +/- 4.4) U/mg pro].	Proline	108-111	angiotensin I converting enzyme	Rattus norvegicus	0-3
14728886-15	2003	AngII concentrations in the kidney of GH-treated AN rats [(17.8 +/- 3.3) pg/mg pro] and GH-treated AN rats plus irbesartan [(27.3 +/- 5.1) pg/mg pro] were significantly higher than that in AN rats [(8.3 +/- 1.9) pg/mg pro] (P &lt; 0.01).	Proline	79-82	angiotensinogen	Rattus norvegicus	0-5
14728886-15	2003	AngII concentrations in the kidney of GH-treated AN rats [(17.8 +/- 3.3) pg/mg pro] and GH-treated AN rats plus irbesartan [(27.3 +/- 5.1) pg/mg pro] were significantly higher than that in AN rats [(8.3 +/- 1.9) pg/mg pro] (P &lt; 0.01).	Proline	145-148	angiotensinogen	Rattus norvegicus	0-5
12893833-4	2003	PRAP contains a coiled-coil domain, a pleckstrin homology domain, and a SH3 domain; the SH3 domain binds to the proline-rich domain of Pyk2/RAFTK.	Proline	112-119	src kinase associated phosphoprotein 2	Homo sapiens	0-4
12893833-4	2003	PRAP contains a coiled-coil domain, a pleckstrin homology domain, and a SH3 domain; the SH3 domain binds to the proline-rich domain of Pyk2/RAFTK.	Proline	112-119	protein tyrosine kinase 2 beta	Homo sapiens	135-139
12893833-4	2003	PRAP contains a coiled-coil domain, a pleckstrin homology domain, and a SH3 domain; the SH3 domain binds to the proline-rich domain of Pyk2/RAFTK.	Proline	112-119	protein tyrosine kinase 2 beta	Homo sapiens	140-145
12902327-4	2003	Conversely, expression of a proline to alanine (P309,310A) PTP1B mutant, which cannot activate Src, fails to activate Rho GTPases or cause changes in actin organization.	Proline	28-35	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	59-64
14511678-5	2003	ACC-CREBp was a variant (Arg to Pro) of ACC-CREB, a hybrid peptide consisting of a 9-amino-acid peptide from rat acetyl-CoA carboxylase (ACC), CREB peptide, and the addition of two hydrophobic Leu residues.	Proline	32-35	cAMP responsive element binding protein 1	Rattus norvegicus	4-9
12829582-3	2003	GPVI genotype had a significant effect on receptor levels with carriers of the proline 219 allele (approximately 22% of the population) having 10% lower GPVI levels than the more common serine homozygotes.	Proline	79-86	glycoprotein VI platelet	Homo sapiens	0-4
12829582-3	2003	GPVI genotype had a significant effect on receptor levels with carriers of the proline 219 allele (approximately 22% of the population) having 10% lower GPVI levels than the more common serine homozygotes.	Proline	79-86	glycoprotein VI platelet	Homo sapiens	153-157
14511678-5	2003	ACC-CREBp was a variant (Arg to Pro) of ACC-CREB, a hybrid peptide consisting of a 9-amino-acid peptide from rat acetyl-CoA carboxylase (ACC), CREB peptide, and the addition of two hydrophobic Leu residues.	Proline	32-35	cAMP responsive element binding protein 1	Rattus norvegicus	4-8
14511678-5	2003	ACC-CREBp was a variant (Arg to Pro) of ACC-CREB, a hybrid peptide consisting of a 9-amino-acid peptide from rat acetyl-CoA carboxylase (ACC), CREB peptide, and the addition of two hydrophobic Leu residues.	Proline	32-35	cAMP responsive element binding protein 1	Rattus norvegicus	44-48
14581358-0	2003	Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients.	Proline	126-133	tumor protein p53	Homo sapiens	17-20
14581358-5	2003	RESULTS: We found that the retention of the p53 codon 72 arginine allele in the tumor tissue of proline/arginine heterozygous breast cancer patients is associated with statistically significant reduced disease-free and overall survivals.	Proline	96-103	tumor protein p53	Homo sapiens	44-47
14581358-6	2003	CONCLUSIONS: Our findings suggest that the genotyping for p53 codon 72 locus in both the tumor tissue and in the lymph node of breast cancer patients could contribute to identify a subset of arginine/proline heterozygous patients who have a reduced survival that is associated with the specific retention of the arginine allele in the tumor tissue.	Proline	200-207	tumor protein p53	Homo sapiens	58-61
12874286-4	2003	This motif was indispensable for CIN85 binding to Cbl/Cbl-b, to other CIN85 SH3 domains" effectors, and for mediating an intramolecular interaction between the SH3-A domain and the proline-rich region of CIN85.	Proline	181-188	SH3 domain containing kinase binding protein 1	Homo sapiens	33-38
12874286-4	2003	This motif was indispensable for CIN85 binding to Cbl/Cbl-b, to other CIN85 SH3 domains" effectors, and for mediating an intramolecular interaction between the SH3-A domain and the proline-rich region of CIN85.	Proline	181-188	Cbl proto-oncogene	Homo sapiens	50-53
12874286-0	2003	Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.	Proline	26-33	SH3 domain containing kinase binding protein 1	Homo sapiens	61-66
12874286-4	2003	This motif was indispensable for CIN85 binding to Cbl/Cbl-b, to other CIN85 SH3 domains" effectors, and for mediating an intramolecular interaction between the SH3-A domain and the proline-rich region of CIN85.	Proline	181-188	Cbl proto-oncogene B	Homo sapiens	54-59
12874286-0	2003	Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.	Proline	26-33	Cbl proto-oncogene	Homo sapiens	91-94
14521407-4	2003	The SAR of the functionality on the proline nitrogen has shown that derivatives of para-substituted phenyl ureas &gt; para-substituted phenyl sulfonamides &gt; para-substituted phenyl carboxamide for activity against HCMV deltaAla protease, producing para-substituted phenyl ureas with single figure nM potency (K(i)) against the viral enzyme.	Proline	36-43	sarcosine dehydrogenase	Homo sapiens	4-7
12893824-3	2003	The c-Abl and Arg SH3 domains bind directly to a proline-rich site in GPx1 at amino acids 132-145.	Proline	49-56	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	4-9
12893824-3	2003	The c-Abl and Arg SH3 domains bind directly to a proline-rich site in GPx1 at amino acids 132-145.	Proline	49-56	glutathione peroxidase 1	Homo sapiens	70-74
12869545-2	2003	We generated mice with a point mutation in the thyroid hormone receptor alpha (TRalpha) gene producing a dominant-negative TRalpha mutant receptor with a proline to histidine substitution (P398H).	Proline	154-161	thyroid hormone receptor alpha	Mus musculus	47-77
12860994-1	2003	Alix (ALG-2-interacting protein X) is a 95-kDa protein that interacts with an EF-hand type Ca(2+)-binding protein, ALG-2 (apoptosis-linked gene 2), through its C-terminal proline-rich region.	Proline	171-178	programmed cell death 6 interacting protein	Homo sapiens	0-4
12837132-2	2003	Among mammalian cysteine proteases, cathepsin K has a unique preference for a proline residue at P2, the primary determinant of its substrate specificity.	Proline	78-85	cathepsin K	Homo sapiens	36-47
12860994-1	2003	Alix (ALG-2-interacting protein X) is a 95-kDa protein that interacts with an EF-hand type Ca(2+)-binding protein, ALG-2 (apoptosis-linked gene 2), through its C-terminal proline-rich region.	Proline	171-178	programmed cell death 6 interacting protein	Homo sapiens	6-33
12869545-2	2003	We generated mice with a point mutation in the thyroid hormone receptor alpha (TRalpha) gene producing a dominant-negative TRalpha mutant receptor with a proline to histidine substitution (P398H).	Proline	154-161	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	79-86
12860994-1	2003	Alix (ALG-2-interacting protein X) is a 95-kDa protein that interacts with an EF-hand type Ca(2+)-binding protein, ALG-2 (apoptosis-linked gene 2), through its C-terminal proline-rich region.	Proline	171-178	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	6-11
12860994-1	2003	Alix (ALG-2-interacting protein X) is a 95-kDa protein that interacts with an EF-hand type Ca(2+)-binding protein, ALG-2 (apoptosis-linked gene 2), through its C-terminal proline-rich region.	Proline	171-178	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	122-145
12874273-6	2003	Moreover, Rac1 associates to the adapter protein Crk via the N-terminal Src homology 3 (SH3) domain of Crk and the proline-rich stretch in the Rac1 C terminus.	Proline	115-122	Rac family small GTPase 1	Homo sapiens	10-14
12874273-6	2003	Moreover, Rac1 associates to the adapter protein Crk via the N-terminal Src homology 3 (SH3) domain of Crk and the proline-rich stretch in the Rac1 C terminus.	Proline	115-122	CRK proto-oncogene, adaptor protein	Homo sapiens	49-52
12874273-6	2003	Moreover, Rac1 associates to the adapter protein Crk via the N-terminal Src homology 3 (SH3) domain of Crk and the proline-rich stretch in the Rac1 C terminus.	Proline	115-122	Rac family small GTPase 1	Homo sapiens	143-147
12869545-2	2003	We generated mice with a point mutation in the thyroid hormone receptor alpha (TRalpha) gene producing a dominant-negative TRalpha mutant receptor with a proline to histidine substitution (P398H).	Proline	154-161	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	123-130
13679040-2	2003	The cytoplasmic domain comprises 103 amino acids containing proline-rich endophilin I, Src homology 3 (SH3), and phox homology domain-containing protein (SH3PX1) binding motifs.	Proline	60-67	SH3-domain GRB2-like 2	Mus musculus	73-85
12876291-2	2003	Hypoxia reduces activity of prolyl hydroxylases (PHD) that hydroxylate specific proline residues in the oxygen-dependent degradation domain (ODD) of hypoxia-inducible factor-1alpha (HIF-1alpha).	Proline	80-87	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	49-52
12876291-2	2003	Hypoxia reduces activity of prolyl hydroxylases (PHD) that hydroxylate specific proline residues in the oxygen-dependent degradation domain (ODD) of hypoxia-inducible factor-1alpha (HIF-1alpha).	Proline	80-87	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	149-180
12876291-2	2003	Hypoxia reduces activity of prolyl hydroxylases (PHD) that hydroxylate specific proline residues in the oxygen-dependent degradation domain (ODD) of hypoxia-inducible factor-1alpha (HIF-1alpha).	Proline	80-87	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	182-192
13679055-0	2003	Indolicidin, a 13-residue basic antimicrobial peptide rich in tryptophan and proline, interacts with Ca(2+)-calmodulin.	Proline	77-84	cathelicidin-4	Bos taurus	0-11
14586131-3	2003	The locations of hydrophobic amino acids and Pro in the 10 kDa domain of the two basidiomycetous enzymes are very similar to those of RNase Rny1, indicating that these domains may have similar roles.	Proline	45-48	ribonuclease T2	Saccharomyces cerevisiae S288C	140-144
13679055-0	2003	Indolicidin, a 13-residue basic antimicrobial peptide rich in tryptophan and proline, interacts with Ca(2+)-calmodulin.	Proline	77-84	calmodulin	Bos taurus	108-118
13679055-6	2003	Replacement of either the proline residues of indolicidin with alanines or tryptophan residues with phenylalanines did not affect binding to calmodulin.	Proline	26-33	cathelicidin-4	Bos taurus	46-57
14579742-3	2003	CD26/DPPIV catalyzes cleavage of peptides from the amino terminus of peptides with proline at the penultimate position.	Proline	83-90	dipeptidyl peptidase 4	Homo sapiens	0-4
14579742-3	2003	CD26/DPPIV catalyzes cleavage of peptides from the amino terminus of peptides with proline at the penultimate position.	Proline	83-90	dipeptidyl peptidase 4	Homo sapiens	5-10
13679389-6	2003	cAMP-dependent protein kinase (PKA) phosphorylates CIITA, and serine residues residing in a region between the proline/serine/threonine-rich domain and the GTP-binding domain are phosphorylated by PKA in vitro.	Proline	111-118	class II major histocompatibility complex transactivator	Homo sapiens	51-56
14514601-0	2003	Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes.	Proline	49-56	peroxisome proliferator activated receptor gamma	Homo sapiens	97-106
14517252-0	2003	Modulation of transcription factor function by an amino acid: activation of Put3p by proline.	Proline	85-92	Put3p	Saccharomyces cerevisiae S288C	76-81
14517252-2	2003	Here, we show that the activator of the proline utilization genes, Put3p, is transcriptionally inert in the absence of proline but transcriptionally active in its presence.	Proline	40-47	Put3p	Saccharomyces cerevisiae S288C	67-72
14517252-2	2003	Here, we show that the activator of the proline utilization genes, Put3p, is transcriptionally inert in the absence of proline but transcriptionally active in its presence.	Proline	119-126	Put3p	Saccharomyces cerevisiae S288C	67-72
14517252-3	2003	The activation of Put3p requires no additional yeast proteins and can occur in the presence of certain proline analogues: an unmodified pyrrolidine ring is able to activate Put3p as efficiently as proline itself.	Proline	103-110	Put3p	Saccharomyces cerevisiae S288C	18-23
14517252-3	2003	The activation of Put3p requires no additional yeast proteins and can occur in the presence of certain proline analogues: an unmodified pyrrolidine ring is able to activate Put3p as efficiently as proline itself.	Proline	103-110	Put3p	Saccharomyces cerevisiae S288C	173-178
14517252-3	2003	The activation of Put3p requires no additional yeast proteins and can occur in the presence of certain proline analogues: an unmodified pyrrolidine ring is able to activate Put3p as efficiently as proline itself.	Proline	197-204	Put3p	Saccharomyces cerevisiae S288C	18-23
14517252-4	2003	In addition, we show that a direct interaction occurs between Put3p and proline.	Proline	72-79	Put3p	Saccharomyces cerevisiae S288C	62-67
14519118-5	2003	It was found that two HCF152 polypeptides bind to form a homodimer, and that this binding is impaired by a single amino acid substitute near the carboxyl terminus, replacing leucine with proline.	Proline	187-194	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	22-28
14507877-5	2003	Cytochalasin D (an inhibitor of microfilament formation) and the peptide GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro), a fibronectin receptor antagonist, each inhibited this effect of fibronectin, whereas nocodazole (an inhibitor of microtubule polymerization) and the control peptide GRGESP (Gly-Arg-Gly-Glu-Ser-Pro) did not.	Proline	101-104	fibronectin 1	Bos taurus	109-120
14507877-5	2003	Cytochalasin D (an inhibitor of microfilament formation) and the peptide GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro), a fibronectin receptor antagonist, each inhibited this effect of fibronectin, whereas nocodazole (an inhibitor of microtubule polymerization) and the control peptide GRGESP (Gly-Arg-Gly-Glu-Ser-Pro) did not.	Proline	101-104	fibronectin 1	Bos taurus	172-183
14577584-0	2003	Polymorphism of the p53 codon 72 Arg/Pro and the risk of HPV type 16/18-associated cervical and oral cancer in India.	Proline	37-40	tumor protein p53	Homo sapiens	20-23
14577584-3	2003	This degradation is controlled by a common polymorphism of the p53 gene encoding either a proline or an arginine at its codon 72 in exon 4.	Proline	90-97	tumor protein p53	Homo sapiens	63-66
14572467-4	2003	The AP-2epsilon protein is very similar to the other family members in its DNA binding and dimerization domain and also contains conserved proline and aromatic amino acid residues in the activation domain.	Proline	139-146	transcription factor AP-2, epsilon	Mus musculus	4-15
14577584-4	2003	Recently, it has been demonstrated that the presence of homozygous arginine at codon 72 renders p53 about seven times more susceptible to E6-mediated proteolytic degradation as well as to cervical cancer than those with proline homozygotes or proline/arginine heterozygotes.	Proline	243-250	tumor protein p53	Homo sapiens	96-99
14750520-3	2003	DRP2A (ADL6) is one of the two members that contain a pleckstrin homology (PH) domain and a proline-rich (PR) motif, characteristics of animal dynamins.	Proline	92-99	dynamin-like protein 6	Arabidopsis thaliana	0-5
14500838-0	2003	dsRBM1 and a proline-rich domain of RNA helicase A can form a composite binder to recognize a specific dsDNA.	Proline	13-20	DExH-box helicase 9	Homo sapiens	36-50
14500838-4	2003	We show here that the dsRBM1 of RNA helicase A (RHA) can cooperate with a C-terminal domain of proline-rich content to gain novel nucleic acid-binding activities.	Proline	95-102	DExH-box helicase 9	Homo sapiens	32-46
14500838-4	2003	We show here that the dsRBM1 of RNA helicase A (RHA) can cooperate with a C-terminal domain of proline-rich content to gain novel nucleic acid-binding activities.	Proline	95-102	DExH-box helicase 9	Homo sapiens	48-51
14750520-3	2003	DRP2A (ADL6) is one of the two members that contain a pleckstrin homology (PH) domain and a proline-rich (PR) motif, characteristics of animal dynamins.	Proline	92-99	dynamin-like protein 6	Arabidopsis thaliana	7-11
14500784-6	2003	The addition of NH4+ to yeast cells growing on l-proline induced rapid ubiquitination, endocytosis, and vacuolar degradation of the plasma membrane protein Gap1.	Proline	47-56	amino acid permease GAP1	Saccharomyces cerevisiae S288C	156-160
14502124-11	2003	Mutational analysis of the Pgamma-rod-FBP17 interaction confirmed it involved the proline-rich domain of Pgamma-rod and the SH3 domain of FBP17.	Proline	82-89	formin binding protein 1	Rattus norvegicus	138-143
12816538-1	2003	To understand the structural basis of molecular elasticity and protein interaction of the elastic PEVK (Pro-Glu-Val-Lys) segment of the giant muscle protein titin, we carried out a detailed analysis of a representative PEVK module and a 16-module PEVK protein under various environmental conditions.	Proline	104-107	titin	Homo sapiens	157-162
14502124-12	2003	This proline-rich domain also allowed Pgamma-rod to interact with Cdc42-interacting protein 4 (CIP4), another SH3-containing protein.	Proline	5-12	thyroid hormone receptor interactor 10	Rattus norvegicus	66-93
14502124-11	2003	Mutational analysis of the Pgamma-rod-FBP17 interaction confirmed it involved the proline-rich domain of Pgamma-rod and the SH3 domain of FBP17.	Proline	82-89	formin binding protein 1	Rattus norvegicus	38-43
14502124-12	2003	This proline-rich domain also allowed Pgamma-rod to interact with Cdc42-interacting protein 4 (CIP4), another SH3-containing protein.	Proline	5-12	thyroid hormone receptor interactor 10	Rattus norvegicus	95-99
12826010-2	2003	We have shown previously that PRH contains two domains that can bring about transcriptional repression independently; the PRH homeodomain represses transcription by binding to TATA box sequences, whereas the proline-rich N-terminal domain can repress transcription by interacting with members of the Groucho/TLE (transducin-like enhancer of split) family of co-repressor proteins.	Proline	208-215	hematopoietically expressed homeobox	Homo sapiens	30-33
12919725-1	2003	The p53 gene has a polymorphism at codon 72 that presents the arginine or proline genotype, although this polymorphism has been associated with genetically determined susceptibility to lung cancers, the literature has not been consistent with this association.	Proline	74-81	tumor protein p53	Homo sapiens	4-7
12826010-6	2003	Moreover, we show that PRH is associated with the proteasome in haematopoietic cells and that the proline-rich PRH N-terminal domain is responsible for this interaction.	Proline	98-105	hematopoietically expressed homeobox	Homo sapiens	23-26
12826010-6	2003	Moreover, we show that PRH is associated with the proteasome in haematopoietic cells and that the proline-rich PRH N-terminal domain is responsible for this interaction.	Proline	98-105	hematopoietically expressed homeobox	Homo sapiens	111-114
12941616-4	2003	Additional data indicate that the SH3 domain of PLCgamma1 binds to both canonical and noncanonical SH3 domain-binding sites in the proline-rich region of c-Cbl.	Proline	131-138	phospholipase C gamma 1	Homo sapiens	48-57
12972323-1	2003	Dipeptidyl-peptidase IV (DPPIV) is involved in endocrine and immune functions via cleavage of regulatory peptides with a N-terminal proline or alanine such as incretins, neuropeptide Y, or several chemokines.	Proline	132-139	dipeptidylpeptidase 4	Rattus norvegicus	0-23
12972323-1	2003	Dipeptidyl-peptidase IV (DPPIV) is involved in endocrine and immune functions via cleavage of regulatory peptides with a N-terminal proline or alanine such as incretins, neuropeptide Y, or several chemokines.	Proline	132-139	dipeptidylpeptidase 4	Rattus norvegicus	25-30
12941616-4	2003	Additional data indicate that the SH3 domain of PLCgamma1 binds to both canonical and noncanonical SH3 domain-binding sites in the proline-rich region of c-Cbl.	Proline	131-138	Cbl proto-oncogene	Homo sapiens	154-159
14521712-2	2003	Under normoxic conditions, the alpha subunit of HIF is rapidly degraded in a manner dependent on hydroxylation of two conserved proline residues at positions 402 and 564 in HIF-1alpha in the oxygen-dependent degradation (ODD) domain.	Proline	128-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	173-183
12955676-1	2003	BACKGROUND: Human serum immunoglobulin A1 (IgA1) has a unique mucine-like structure in its hinge region that contains O-glycans and proline-rich peptides.	Proline	132-139	immunoglobulin heavy constant alpha 1	Homo sapiens	24-41
12927772-6	2003	These data demonstrate that XMI-ER1 is a negative regulator of FGF, perhaps serving to limit the extent of mesoderm formation in vivo, and that this activity is mediated by proline 365.	Proline	173-180	mesoderm induction early response 1, transcriptional regulator L homeolog	Xenopus laevis	28-35
12948592-0	2003	Mutation of proline residues in the NH(2)-terminal region of the multidrug resistance protein, MRP1 (ABCC1): effects on protein expression, membrane localization, and transport function.	Proline	12-19	ATP binding cassette subfamily C member 1	Homo sapiens	95-99
12948592-0	2003	Mutation of proline residues in the NH(2)-terminal region of the multidrug resistance protein, MRP1 (ABCC1): effects on protein expression, membrane localization, and transport function.	Proline	12-19	ATP binding cassette subfamily C member 1	Homo sapiens	101-106
12819203-10	2003	In addition, GC-GAP contains several classic proline-rich motifs, and it interacts with the first SH3 domain of Crk and full-length Nck in vitro.	Proline	45-52	Rho GTPase activating protein 32	Homo sapiens	13-19
12955676-1	2003	BACKGROUND: Human serum immunoglobulin A1 (IgA1) has a unique mucine-like structure in its hinge region that contains O-glycans and proline-rich peptides.	Proline	132-139	immunoglobulin heavy constant alpha 1	Homo sapiens	43-47
12939659-3	2003	SSCP/sequencing analysis of the spastin gene showed a single base pair deletion causing a frame-shift in one family (1442delT) and a missense mutation (1726T&gt;C) resulting in a leucine to proline amino-acid change (L534P) in the other family.	Proline	190-197	spastin	Homo sapiens	32-39
14686874-11	2003	Leucine or proline would be encoded at amino acid 141 of HMW-uPA as the result of an SNP at base pair 422.	Proline	11-18	cilia and flagella associated protein 97	Homo sapiens	57-60
14686874-11	2003	Leucine or proline would be encoded at amino acid 141 of HMW-uPA as the result of an SNP at base pair 422.	Proline	11-18	plasminogen activator, urokinase	Homo sapiens	61-64
12868034-2	2003	Direct sequencing of the SSCP variants revealed a nonsense mutation (R317X) in the eleventh exon leading to a premature termination of the PAX6 protein in the proline-serine-threonine (PST)-rich domain in two probands.	Proline	159-166	paired box 6	Homo sapiens	139-143
14502423-4	2003	The results demonstrate ASCT1-mediated proline transport that is Na(+)-dependent, saturable, inhibited by the reported ASCT1 substrates as well as by hydroxyproline and can drive the imino acid against its concentration gradient.	Proline	39-46	solute carrier family 1 member 4	Homo sapiens	24-29
14502423-4	2003	The results demonstrate ASCT1-mediated proline transport that is Na(+)-dependent, saturable, inhibited by the reported ASCT1 substrates as well as by hydroxyproline and can drive the imino acid against its concentration gradient.	Proline	39-46	solute carrier family 1 member 4	Homo sapiens	119-124
14502423-6	2003	However, K(0.5) for proline was 704 +/- 86 microM, about three times higher than alanine K(0.5) (203.3 +/- 36.4 microM), whereas hydroxyproline K(0.5) was 33.2 +/- 4.3 microM, indicating that the hydroxylation on carbon 4 of proline strongly increases the affinity of ASCT1 for this proline derivative.	Proline	20-27	solute carrier family 1 member 4	Homo sapiens	268-273
14502423-7	2003	In summary, the present work demonstrates for the first time the ability of ASCT1 to transport proline and hydroxyproline.	Proline	95-102	solute carrier family 1 member 4	Homo sapiens	76-81
12915533-1	2003	The structural precursor polyprotein of human immunodeficiency virus type 1, Pr55(gag), contains a proline-rich motif (PTAP) called the "late domain" in its C-terminal p6 region that directs release of mature virus-like particles (VLPs) from the plasma membranes of gag-transfected COS-1 cells.	Proline	99-106	Pr55(Gag)	Human immunodeficiency virus 1	77-86
12915533-1	2003	The structural precursor polyprotein of human immunodeficiency virus type 1, Pr55(gag), contains a proline-rich motif (PTAP) called the "late domain" in its C-terminal p6 region that directs release of mature virus-like particles (VLPs) from the plasma membranes of gag-transfected COS-1 cells.	Proline	99-106	Pr55(Gag)	Human immunodeficiency virus 1	82-85
12917324-5	2003	We have mapped the transactivation potential of EYA to an internal proline-, serine-, and threonine-rich region that includes the EYA domain 2 (ED2) and two MAPK phosphorylation consensus sites and demonstrate that activation of the RAS/MAPK pathway potentiates transcriptional output of EYA and the EYA-SO complex in certain contexts.	Proline	67-74	eyes absent	Drosophila melanogaster	48-51
14502423-0	2003	Transport of proline and hydroxyproline by the neutral amino-acid exchanger ASCT1.	Proline	13-20	solute carrier family 1 member 4	Homo sapiens	76-81
12949183-3	2003	The gene could functionally complement an S. cerevisiae gap1 mutant by rendering it susceptible to the toxic amino acid analogue mimosine in minimal proline media.	Proline	149-156	amino acid permease GAP1	Saccharomyces cerevisiae S288C	56-60
12956884-1	2003	The novel allele DRB1*0445 differs from DRB1*04051 by a single nucleotide substitution at codon 23 (CGG--&gt;CCG), resulting in an amino-acid change from arginine to proline.	Proline	166-173	major histocompatibility complex, class II, DR beta 1	Homo sapiens	17-21
12956884-1	2003	The novel allele DRB1*0445 differs from DRB1*04051 by a single nucleotide substitution at codon 23 (CGG--&gt;CCG), resulting in an amino-acid change from arginine to proline.	Proline	166-173	major histocompatibility complex, class II, DR beta 1	Homo sapiens	40-44
12911295-1	2003	The objective of this study was to determine the effects of proline hydroxylation in the collagen-like domain and Asn(187)-linked glycosylation in the globular domain on the molecular and functional properties of human surfactant protein A1 (SP-A1).	Proline	60-67	surfactant protein A1	Homo sapiens	219-240
14621294-11	2003	Experiments with the truncated ZNF219 constructs suggest that the proline-rich sequence (226-272 a.a., proline content 49%) was responsible for part of the observed repression.	Proline	66-73	zinc finger protein 219	Homo sapiens	31-37
14621294-11	2003	Experiments with the truncated ZNF219 constructs suggest that the proline-rich sequence (226-272 a.a., proline content 49%) was responsible for part of the observed repression.	Proline	103-110	zinc finger protein 219	Homo sapiens	31-37
12771153-6	2003	Mutation analysis indicates that a 17-amino acid sequence in GIGYF1 and GIGYF2, homologous to the GYF domain described previously, binds to tandem proline-rich regions in the N terminus of Grb10.	Proline	147-154	GRB10 interacting GYF protein 1	Homo sapiens	61-67
12771153-6	2003	Mutation analysis indicates that a 17-amino acid sequence in GIGYF1 and GIGYF2, homologous to the GYF domain described previously, binds to tandem proline-rich regions in the N terminus of Grb10.	Proline	147-154	GRB10 interacting GYF protein 2	Homo sapiens	72-78
12771153-6	2003	Mutation analysis indicates that a 17-amino acid sequence in GIGYF1 and GIGYF2, homologous to the GYF domain described previously, binds to tandem proline-rich regions in the N terminus of Grb10.	Proline	147-154	growth factor receptor bound protein 10	Homo sapiens	189-194
12873514-1	2003	A series of potent and selective proline- and pyrazinone-based macrocyclic thrombin inhibitors is described.	Proline	33-40	coagulation factor II, thrombin	Homo sapiens	75-83
12801934-3	2003	We show that A beta 42 elicited rapid and reversible tau protein phosphorylation on three proline-directed sites (Ser-202, Thr-181, and Thr-231) in systems enriched in alpha 7 nicotinic acetylcholine receptors (alpha 7nAChR) including serum-deprived human SK-N-MC neuroblastoma cells and hippocampal synaptosomes.	Proline	90-97	amyloid beta precursor protein	Homo sapiens	13-19
12893300-0	2003	Catalytic oxidation of acetaminophen by tyrosinase in the presence of L-proline: a kinetic study.	Proline	70-79	tyrosinase	Homo sapiens	40-50
12932330-7	2003	Mutation of proline residues (Pro2) in the amino-terminal region of FAK blocks direct binding with Calpain 2 and also prevents formation of the Calpain 2/p42ERK complex in cells.	Proline	12-19	protein tyrosine kinase 2	Homo sapiens	68-71
12932330-7	2003	Mutation of proline residues (Pro2) in the amino-terminal region of FAK blocks direct binding with Calpain 2 and also prevents formation of the Calpain 2/p42ERK complex in cells.	Proline	12-19	calpain 2	Homo sapiens	99-108
12932330-7	2003	Mutation of proline residues (Pro2) in the amino-terminal region of FAK blocks direct binding with Calpain 2 and also prevents formation of the Calpain 2/p42ERK complex in cells.	Proline	12-19	calpain 2	Homo sapiens	144-153
12890487-3	2003	During the search for interacting molecules with the COOH-terminal proline-rich region of p73, we identified a novel NEDD4-related protein (termed as NEDL2) which contains a C2 domain at its NH(2)-terminus, two WW domains, and a HECT domain at its COOH-terminus.	Proline	67-74	tumor protein p73	Homo sapiens	90-93
12878203-6	2003	Kinetic studies indicated that hK6 cleaved with much higher efficiency after Arg than Lys and with a preference for Ser or Pro in the P2 position.	Proline	123-126	kallikrein related peptidase 6	Homo sapiens	31-34
12890487-3	2003	During the search for interacting molecules with the COOH-terminal proline-rich region of p73, we identified a novel NEDD4-related protein (termed as NEDL2) which contains a C2 domain at its NH(2)-terminus, two WW domains, and a HECT domain at its COOH-terminus.	Proline	67-74	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	150-155
12951035-6	2003	ADP mutants with deletions throughout the bait region do not interact with human MAD2B, whereas a Pro69Pro70 to Ala69Ala70 mutant in the "basic-proline" domain of ADP does interact.	Proline	144-151	WD and tetratricopeptide repeats 1	Homo sapiens	163-166
12771146-4	2003	Pyk2-ASAP1 interaction was confirmed in pull-down as well as in co-immunoprecipitation experiments, and contact sites were mapped to the proline-rich regions of Pyk2 and the SH3 domain of ASAP1.	Proline	137-144	protein tyrosine kinase 2 beta	Homo sapiens	0-4
12771146-4	2003	Pyk2-ASAP1 interaction was confirmed in pull-down as well as in co-immunoprecipitation experiments, and contact sites were mapped to the proline-rich regions of Pyk2 and the SH3 domain of ASAP1.	Proline	137-144	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	5-10
12771146-4	2003	Pyk2-ASAP1 interaction was confirmed in pull-down as well as in co-immunoprecipitation experiments, and contact sites were mapped to the proline-rich regions of Pyk2 and the SH3 domain of ASAP1.	Proline	137-144	protein tyrosine kinase 2 beta	Homo sapiens	161-165
12771146-4	2003	Pyk2-ASAP1 interaction was confirmed in pull-down as well as in co-immunoprecipitation experiments, and contact sites were mapped to the proline-rich regions of Pyk2 and the SH3 domain of ASAP1.	Proline	137-144	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	188-193
12777393-3	2003	Here we show that Dok-R associates with c-Abl directly via a constitutive SH3-mediated interaction and that this binding requires a PMMP motif in the proline-rich tail of Dok-R.	Proline	150-157	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	40-45
12906795-2	2003	Formins are defined by a Formin Homology 2 (FH2) domain, as well as a proline-rich FH1 domain that binds the actin monomer binding protein, profilin, and other ligands.	Proline	70-77	fumarate hydratase 1	Mus musculus	83-86
12733990-9	2003	We further explored the acceptance of a Pro residue in the P2 position by cathepsin K in order to develop specific substrates for the enzyme.	Proline	40-43	cathepsin K	Homo sapiens	74-85
12741956-10	2003	The dimerization domain with both ZHX1 and ZHX2 is the region containing HD1, the domain that interacts with NF-YA is the HD1 to HD2 region, the repressor domain is the HD1 to a proline-rich region.	Proline	178-185	Nuclear factor Y-box A	Drosophila melanogaster	109-114
12892755-2	2003	Glutamate synthesized by GDH via reductive amination is the amino group donor for alanine synthesis and the precursor required for proline synthesis.	Proline	131-138	glutamate dehydrogenase 1	Homo sapiens	25-28
12741956-10	2003	The dimerization domain with both ZHX1 and ZHX2 is the region containing HD1, the domain that interacts with NF-YA is the HD1 to HD2 region, the repressor domain is the HD1 to a proline-rich region.	Proline	178-185	Ror	Drosophila melanogaster	129-132
12892755-3	2003	Since both proline and alanine are important intracellular osmolytes in many marine invertebrates, GDH has been widely implicated as playing a central role in response to hyperosmotic stress in these organisms.	Proline	11-18	Glutamate dehydrogenase	Drosophila melanogaster	99-102
12941425-3	2003	More distant members include prolyl oligopeptidase (POP; post proline cleaving enzyme) and acylaminoacylpeptidase (AAP; acylpeptide hydrolase).	Proline	62-69	prolyl endopeptidase	Homo sapiens	29-50
12941425-3	2003	More distant members include prolyl oligopeptidase (POP; post proline cleaving enzyme) and acylaminoacylpeptidase (AAP; acylpeptide hydrolase).	Proline	62-69	prolyl endopeptidase	Homo sapiens	52-55
12874225-5	2003	Analyses of various mutants of each molecule revealed that the region including the proline-rich domain in SPHK2 is probably responsible for the binding to IL-12Rbeta1, while the regions including the carboxyl terminus and Box II in the IL-12Rbeta1 cytoplasmic region appear to be involved in the binding to SPHK2.	Proline	84-91	sphingosine kinase 2	Mus musculus	107-112
12890816-0	2003	Measurement of 5-hydroxy-2-aminovaleric acid as a specific marker of metal catalysed oxidation of proline and arginine residues of low density lipoprotein apolipoprotein B-100 in human atherosclerotic lesions.	Proline	98-105	apolipoprotein B	Homo sapiens	155-175
12890816-1	2003	gamma-Glutamyl-semialdehyde (gammaGSA) is a major product of the metal catalysed oxidation of apolipoprotein B-100 (apoB-100) proline and arginine residues.	Proline	126-133	apolipoprotein B	Homo sapiens	94-114
12890816-1	2003	gamma-Glutamyl-semialdehyde (gammaGSA) is a major product of the metal catalysed oxidation of apolipoprotein B-100 (apoB-100) proline and arginine residues.	Proline	126-133	apolipoprotein B	Homo sapiens	116-124
12754255-4	2003	This association requires the cytoplasmic C-terminal region of Ror2, containing proline-rich and serine/threonine-rich domains, and the C-terminal necdin homology domain of Dlxin-1.	Proline	80-87	receptor tyrosine kinase like orphan receptor 2	Homo sapiens	63-67
12874225-5	2003	Analyses of various mutants of each molecule revealed that the region including the proline-rich domain in SPHK2 is probably responsible for the binding to IL-12Rbeta1, while the regions including the carboxyl terminus and Box II in the IL-12Rbeta1 cytoplasmic region appear to be involved in the binding to SPHK2.	Proline	84-91	interleukin 12 receptor, beta 1	Mus musculus	156-167
12874226-1	2003	We have shown previously that Wiskott-Aldrich syndrome protein (WASP) activation at the site of T cell-APC interaction is a two-step process, with recruitment dependent on the proline-rich domain and activation dependent on binding of Cdc42-GTP to the GTPase binding domain.	Proline	176-183	WASP actin nucleation promoting factor	Homo sapiens	30-62
12874226-1	2003	We have shown previously that Wiskott-Aldrich syndrome protein (WASP) activation at the site of T cell-APC interaction is a two-step process, with recruitment dependent on the proline-rich domain and activation dependent on binding of Cdc42-GTP to the GTPase binding domain.	Proline	176-183	WASP actin nucleation promoting factor	Homo sapiens	64-68
14682615-0	2003	Repression of formate dehydrogenase in Solanum tuberosum increases steady-state levels of formate and accelerates the accumulation of proline in response to osmotic stress.	Proline	134-141	formate dehydrogenase, mitochondrial	Solanum tuberosum	14-35
14682615-13	2003	Amongst various biochemical and molecular differences between stressed AS23 and control plants, the most striking was a dramatically faster accumulation of proline in the leaves of drought-stressed plants under-expressing FDH.	Proline	156-163	formate dehydrogenase, mitochondrial	Solanum tuberosum	222-225
12833552-4	2003	Accordingly, the Trp-cage-forming interactions emerge successively, first Trp(6)-Pro(12), then Trp(6)-Pro(18), and then Trp(6)-Tyr(3).	Proline	81-84	transient receptor potential cation channel subfamily C member 6	Homo sapiens	74-79
12891359-4	2003	Notably, these phospho(Ser/Thr)-Pro motifs exist in two distinct conformations, whose conversion in some proteins is catalysed by the Pin1 prolyl isomerase.	Proline	30-35	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	134-138
12833552-4	2003	Accordingly, the Trp-cage-forming interactions emerge successively, first Trp(6)-Pro(12), then Trp(6)-Pro(18), and then Trp(6)-Tyr(3).	Proline	81-84	transient receptor potential cation channel subfamily C member 6	Homo sapiens	95-100
12833552-4	2003	Accordingly, the Trp-cage-forming interactions emerge successively, first Trp(6)-Pro(12), then Trp(6)-Pro(18), and then Trp(6)-Tyr(3).	Proline	81-84	transient receptor potential cation channel subfamily C member 6	Homo sapiens	95-100
12833552-4	2003	Accordingly, the Trp-cage-forming interactions emerge successively, first Trp(6)-Pro(12), then Trp(6)-Pro(18), and then Trp(6)-Tyr(3).	Proline	102-105	transient receptor potential cation channel subfamily C member 6	Homo sapiens	74-79
12833552-4	2003	Accordingly, the Trp-cage-forming interactions emerge successively, first Trp(6)-Pro(12), then Trp(6)-Pro(18), and then Trp(6)-Tyr(3).	Proline	102-105	transient receptor potential cation channel subfamily C member 6	Homo sapiens	95-100
12833552-4	2003	Accordingly, the Trp-cage-forming interactions emerge successively, first Trp(6)-Pro(12), then Trp(6)-Pro(18), and then Trp(6)-Tyr(3).	Proline	102-105	transient receptor potential cation channel subfamily C member 6	Homo sapiens	95-100
12873125-2	2003	Recent studies demonstrated that PR39, a natural proline- and arginine-rich antibacterial peptide, stimulates angiogenesis and inhibits inflammatory responses by specifically blocking degradation of IkappaBalpha and HIF-1alpha by the proteasome.	Proline	49-56	NFKB inhibitor alpha	Homo sapiens	199-211
12873125-2	2003	Recent studies demonstrated that PR39, a natural proline- and arginine-rich antibacterial peptide, stimulates angiogenesis and inhibits inflammatory responses by specifically blocking degradation of IkappaBalpha and HIF-1alpha by the proteasome.	Proline	49-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	216-226
12839496-0	2003	Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation.	Proline	107-114	epidermal growth factor receptor	Homo sapiens	0-32
12839496-5	2003	Localization of Cbl-yellow fluorescent protein to these endocytic organelles was dependent on a proline-rich domain of c-Cbl that interacts with Grb2 as shown by fluorescence resonance energy transfer microscopy.	Proline	96-103	Cbl proto-oncogene	Homo sapiens	16-19
12839496-5	2003	Localization of Cbl-yellow fluorescent protein to these endocytic organelles was dependent on a proline-rich domain of c-Cbl that interacts with Grb2 as shown by fluorescence resonance energy transfer microscopy.	Proline	96-103	Cbl proto-oncogene	Homo sapiens	119-124
12839496-5	2003	Localization of Cbl-yellow fluorescent protein to these endocytic organelles was dependent on a proline-rich domain of c-Cbl that interacts with Grb2 as shown by fluorescence resonance energy transfer microscopy.	Proline	96-103	growth factor receptor bound protein 2	Homo sapiens	145-149
12893432-2	2003	To address on the genetic risk factor for NPC, we investigated association between the p53 codon 72 polymorphism (Pro/Arg) and NPC susceptibility in the Thai.	Proline	114-117	tumor protein p53	Homo sapiens	87-90
12738779-5	2003	This consensus sequence was similar to that for other MMPs, which also cleave peptides containing Ala in position 3, Ala in position 1, and Leu/Tyr in position 1", but differed from most other MMP substrates in that proline was rarely found in position 3 and Asn was frequently found in position 1.	Proline	216-223	matrix metallopeptidase 11	Homo sapiens	54-58
12738779-5	2003	This consensus sequence was similar to that for other MMPs, which also cleave peptides containing Ala in position 3, Ala in position 1, and Leu/Tyr in position 1", but differed from most other MMP substrates in that proline was rarely found in position 3 and Asn was frequently found in position 1.	Proline	216-223	matrix metallopeptidase 11	Homo sapiens	54-57
12738779-7	2003	Although other MMPs also cleave peptides with these residues, other MMPs prefer proline at position 3 in this sequence.	Proline	80-87	matrix metallopeptidase 11	Homo sapiens	68-72
12738779-9	2003	These reactions also showed that peptides with proline in position 3 were poor substrates for MMP-11.	Proline	47-54	matrix metallopeptidase 11	Homo sapiens	94-100
12738779-10	2003	A structural basis for the lower kcat/Km values of human MMP-11, relative to other MMPs, and poor cleavage of position 3 proline substrates by MMP-11 is provided.	Proline	121-128	matrix metallopeptidase 11	Homo sapiens	57-63
12738779-10	2003	A structural basis for the lower kcat/Km values of human MMP-11, relative to other MMPs, and poor cleavage of position 3 proline substrates by MMP-11 is provided.	Proline	121-128	matrix metallopeptidase 11	Homo sapiens	143-149
12710888-5	2003	A notable feature of XlGSTP1-1 is the presence in the H-site of Phe(111) and Pro(208) in place of tyrosine and glycine residues respectively, present in other mammalian Pi-class GSTs.	Proline	77-80	glutathione S-transferase pi 1 L homeolog	Xenopus laevis	21-30
12881708-0	2003	The proline-rich region of mouse p53 influences transactivation and apoptosis but is largely dispensable for these functions.	Proline	4-11	transformation related protein 53, pseudogene	Mus musculus	33-36
12881708-1	2003	The N-terminal proline-rich domain of human p53 has been shown to be important for the induction of apoptosis.	Proline	15-22	tumor protein p53	Homo sapiens	44-47
12689336-1	2003	Annexin A11 is one of the 12 vertebrate subfamilies in the annexin superfamily of calcium/phospholipid-binding proteins, distinguishable by long, non-homologous N-termini rich in proline, glycine and tyrosine residues.	Proline	179-186	annexin A11	Mus musculus	0-11
12713446-5	2003	We find that Thr-228 and Ser-370 are crucial for S6K2 activity, and the three proline-directed serines in the autoinhibitory domain, Ser-410, Ser-417 and Ser-423, play a role in S6K2 activity regulation in a mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase (MEK)-dependent manner.	Proline	78-85	ribosomal protein S6 kinase B2	Homo sapiens	178-182
12713446-5	2003	We find that Thr-228 and Ser-370 are crucial for S6K2 activity, and the three proline-directed serines in the autoinhibitory domain, Ser-410, Ser-417 and Ser-423, play a role in S6K2 activity regulation in a mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase (MEK)-dependent manner.	Proline	78-85	mitogen-activated protein kinase kinase 7	Homo sapiens	208-285
12853469-1	2003	The catalytic domain of acetylcholinesterase AChE(T) subunits is followed by a C-terminal T peptide which mediates their association with the proline-rich attachment domain (PRAD) of anchoring proteins.	Proline	142-149	acetylcholinesterase (Cartwright blood group)	Homo sapiens	24-44
12853469-1	2003	The catalytic domain of acetylcholinesterase AChE(T) subunits is followed by a C-terminal T peptide which mediates their association with the proline-rich attachment domain (PRAD) of anchoring proteins.	Proline	142-149	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-49
12713446-5	2003	We find that Thr-228 and Ser-370 are crucial for S6K2 activity, and the three proline-directed serines in the autoinhibitory domain, Ser-410, Ser-417 and Ser-423, play a role in S6K2 activity regulation in a mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase (MEK)-dependent manner.	Proline	78-85	mitogen-activated protein kinase kinase 7	Homo sapiens	287-290
12716893-9	2003	The fusion protein consisting of a Gal-4 DNA binding domain and one or more of the three transactivation domains of MTF1, namely the acidic domain, proline-rich domain, and serine-threonine rich domain, activated the GAL-4-driven luciferase gene to different degrees, but all were sensitive to Cr6+.	Proline	148-155	galectin 4	Homo sapiens	35-40
12832108-2	2003	The peculiarities of their immunoregulatory effects are demonstrated with two of the six synthesized MPs, MP-1 (Phe-Leu-Gly-Phe-Pro-Thr) and MP-2 (Leu-Val-Val-Tyr-Pro-Trp).	Proline	128-131	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	Mus musculus	106-110
12686540-4	2003	Pin1 is able to bind phospho-Ser/Thr-Pro-containing sequences at two different sites that compete for the same substrate.	Proline	37-40	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
12716893-9	2003	The fusion protein consisting of a Gal-4 DNA binding domain and one or more of the three transactivation domains of MTF1, namely the acidic domain, proline-rich domain, and serine-threonine rich domain, activated the GAL-4-driven luciferase gene to different degrees, but all were sensitive to Cr6+.	Proline	148-155	metal regulatory transcription factor 1	Homo sapiens	116-120
12716893-9	2003	The fusion protein consisting of a Gal-4 DNA binding domain and one or more of the three transactivation domains of MTF1, namely the acidic domain, proline-rich domain, and serine-threonine rich domain, activated the GAL-4-driven luciferase gene to different degrees, but all were sensitive to Cr6+.	Proline	148-155	galectin 4	Homo sapiens	217-222
12730223-0	2003	Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway.	Proline	35-42	fibronectin 1	Homo sapiens	0-11
12853970-3	2003	Previously, we and others have shown that some functional domains in p53, such as the DNA-binding and tetramerization domains, are required for inducing both cell cycle arrest and apoptosis whereas others, such as the second activation domain, the proline-rich domain, and the C-terminal basic domain, are only required for inducing apoptosis.	Proline	248-255	tumor protein p53	Homo sapiens	69-72
12709437-6	2003	In addition, proline-rich region of 3BP2 bound to the Lyn-SH3 domain.	Proline	13-20	LYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	54-57
12730223-0	2003	Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway.	Proline	35-42	protein tyrosine kinase 2 beta	Homo sapiens	64-68
12730223-0	2003	Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway.	Proline	35-42	matrix metallopeptidase 13	Homo sapiens	106-119
12700345-1	2003	Apolipoprotein C-IV (apoC-IV), the newest member of the low-molecular-weight apoC group, has been characterized in blood plasma of rabbits, in which it is a major proline-rich apoC component (Zhang, L-H., L. Kotite, and R. J. Havel.	Proline	163-170	apolipoprotein C-IV	Oryctolagus cuniculus	0-19
12650641-1	2003	In an early step in the assembly of the phagocyte NADPH oxidase, p47-phox translocates from the cytosol to the membrane, mediated by engagement of the N-termini of two p47-phox Src homology 3 (SH3) domains with a proline-rich region (PRR) in the p22-phox subunit of cytochrome b (558).	Proline	213-220	pleckstrin	Homo sapiens	65-68
12650641-1	2003	In an early step in the assembly of the phagocyte NADPH oxidase, p47-phox translocates from the cytosol to the membrane, mediated by engagement of the N-termini of two p47-phox Src homology 3 (SH3) domains with a proline-rich region (PRR) in the p22-phox subunit of cytochrome b (558).	Proline	213-220	pleckstrin	Homo sapiens	168-171
12650641-1	2003	In an early step in the assembly of the phagocyte NADPH oxidase, p47-phox translocates from the cytosol to the membrane, mediated by engagement of the N-termini of two p47-phox Src homology 3 (SH3) domains with a proline-rich region (PRR) in the p22-phox subunit of cytochrome b (558).	Proline	213-220	nuclear receptor subfamily 1 group I member 2	Homo sapiens	234-237
12738681-6	2003	ABCA1 contains a PEST--proline (P), glutamate (E), serine (S), and threonine (T)--sequence in the intracellular segment that mediates ABCA1 degradation by a thiol protease, calpain.	Proline	23-30	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
12738681-6	2003	ABCA1 contains a PEST--proline (P), glutamate (E), serine (S), and threonine (T)--sequence in the intracellular segment that mediates ABCA1 degradation by a thiol protease, calpain.	Proline	23-30	ATP binding cassette subfamily A member 1	Homo sapiens	134-139
12817031-4	2003	Human MOG 35-55 was only weakly encephalitogenic, and a proline substitution in rat MOG at position 42 severely attenuated its encephalitogenicity.	Proline	56-63	myelin oligodendrocyte glycoprotein	Rattus norvegicus	84-87
12700345-1	2003	Apolipoprotein C-IV (apoC-IV), the newest member of the low-molecular-weight apoC group, has been characterized in blood plasma of rabbits, in which it is a major proline-rich apoC component (Zhang, L-H., L. Kotite, and R. J. Havel.	Proline	163-170	apolipoprotein C-IV	Oryctolagus cuniculus	21-28
12700345-1	2003	Apolipoprotein C-IV (apoC-IV), the newest member of the low-molecular-weight apoC group, has been characterized in blood plasma of rabbits, in which it is a major proline-rich apoC component (Zhang, L-H., L. Kotite, and R. J. Havel.	Proline	163-170	anterior polar cataract	Mus musculus	21-25
12802020-5	2003	TSG101/HRS interaction occurs between a ubiquitin-binding domain of TSG101 and two distinct proline-rich regions of HRS, and is modulated by a C-terminal TSG101 sequence that resembles a motif targeted in HRS.	Proline	92-99	tumor susceptibility 101	Homo sapiens	0-6
12802020-5	2003	TSG101/HRS interaction occurs between a ubiquitin-binding domain of TSG101 and two distinct proline-rich regions of HRS, and is modulated by a C-terminal TSG101 sequence that resembles a motif targeted in HRS.	Proline	92-99	tumor susceptibility 101	Homo sapiens	68-74
12802020-5	2003	TSG101/HRS interaction occurs between a ubiquitin-binding domain of TSG101 and two distinct proline-rich regions of HRS, and is modulated by a C-terminal TSG101 sequence that resembles a motif targeted in HRS.	Proline	92-99	tumor susceptibility 101	Homo sapiens	68-74
12690097-1	2003	Recruitment of CD2 to the immunological synapse in response to antigen is dependent on its proline-rich cytoplasmic tail.	Proline	91-98	CD2 antigen	Mus musculus	15-18
12668678-2	2003	We determine that KPRP is expressed in stratified squamous epithelium, and its approximately 2.8-kb cDNA encodes a 699-amino acid protein with high proline content (19%).	Proline	148-155	keratinocyte proline-rich protein	Rattus norvegicus	18-22
12672800-8	2003	Similarly, a complex between NF-kappaB and a mutant IkappaBbeta protein containing four serine to alanine mutations within its C-terminal proline, glutamic acid, serine, and threonine-rich sequence exhibits nucleocytoplasmic shuttling.	Proline	138-145	NFKB inhibitor beta	Homo sapiens	52-63
12672800-9	2003	This suggests a phosphorylation state-dependent role for the C-terminal proline, glutamic acid, serine, and threonine-rich sequence of IkappaBbeta in proper localization of IkappaBbeta x NF-kappaB complexes.	Proline	72-79	NFKB inhibitor beta	Homo sapiens	135-146
12576320-3	2003	CD26 has the ability to cleave CXCL12 at its position-2 proline.	Proline	56-63	dipeptidylpeptidase 4	Mus musculus	0-4
12672800-9	2003	This suggests a phosphorylation state-dependent role for the C-terminal proline, glutamic acid, serine, and threonine-rich sequence of IkappaBbeta in proper localization of IkappaBbeta x NF-kappaB complexes.	Proline	72-79	NFKB inhibitor beta	Homo sapiens	173-184
12798690-1	2003	A protein fragment from the Tec family member Rlk (also known as Txk) containing a single proline-rich ligand adjacent to a Src homology 3 (SH3) domain has been investigated by nuclear magnetic resonance (NMR) spectroscopy.	Proline	90-97	TXK tyrosine kinase	Homo sapiens	46-49
12798690-1	2003	A protein fragment from the Tec family member Rlk (also known as Txk) containing a single proline-rich ligand adjacent to a Src homology 3 (SH3) domain has been investigated by nuclear magnetic resonance (NMR) spectroscopy.	Proline	90-97	TXK tyrosine kinase	Homo sapiens	65-68
12798690-5	2003	This is in contrast to the corresponding fragment of Itk, for which the proline-rich ligand/SH3 interaction occurs exclusively in an intramolecular fashion and no intermolecular binding is observed.	Proline	72-79	IL2 inducible T cell kinase	Homo sapiens	53-56
12798690-6	2003	Comparison of the Itk and Rlk sequences reveals that Rlk contains five fewer residues than Itk in the linker region between the proline-rich ligand and the SH3 domain.	Proline	128-135	IL2 inducible T cell kinase	Homo sapiens	18-21
12798690-6	2003	Comparison of the Itk and Rlk sequences reveals that Rlk contains five fewer residues than Itk in the linker region between the proline-rich ligand and the SH3 domain.	Proline	128-135	TXK tyrosine kinase	Homo sapiens	53-56
12798690-6	2003	Comparison of the Itk and Rlk sequences reveals that Rlk contains five fewer residues than Itk in the linker region between the proline-rich ligand and the SH3 domain.	Proline	128-135	IL2 inducible T cell kinase	Homo sapiens	91-94
12798690-8	2003	Intramolecular binding in Itk is reduced by shortening the linker and conversely a longer linker between the proline-rich ligand and the SH3 domain in Rlk enhances intramolecular self-association.	Proline	109-116	IL2 inducible T cell kinase	Homo sapiens	26-29
12798690-8	2003	Intramolecular binding in Itk is reduced by shortening the linker and conversely a longer linker between the proline-rich ligand and the SH3 domain in Rlk enhances intramolecular self-association.	Proline	109-116	TXK tyrosine kinase	Homo sapiens	151-154
12798690-10	2003	The protein/peptide data combined with the association constants for binding of each proline-rich peptide to the corresponding SH3 domain provide an explanation for the opposing modes of self-association within the otherwise closely related Rlk and Itk proteins.	Proline	85-92	TXK tyrosine kinase	Homo sapiens	241-244
12798690-10	2003	The protein/peptide data combined with the association constants for binding of each proline-rich peptide to the corresponding SH3 domain provide an explanation for the opposing modes of self-association within the otherwise closely related Rlk and Itk proteins.	Proline	85-92	IL2 inducible T cell kinase	Homo sapiens	249-252
12576320-3	2003	CD26 has the ability to cleave CXCL12 at its position-2 proline.	Proline	56-63	chemokine (C-X-C motif) ligand 12	Mus musculus	31-37
12810669-2	2003	By analyzing the frequency of a polymorphism within the GPx-1 gene resulting in a leucine or proline at codon 198, it was determined that the leucine-containing allele was more frequently associated with breast cancer than the proline-containing allele (odds ratio = 1.9; P &lt; 0.05).	Proline	93-100	glutathione peroxidase 1	Homo sapiens	56-61
12810669-2	2003	By analyzing the frequency of a polymorphism within the GPx-1 gene resulting in a leucine or proline at codon 198, it was determined that the leucine-containing allele was more frequently associated with breast cancer than the proline-containing allele (odds ratio = 1.9; P &lt; 0.05).	Proline	227-234	glutathione peroxidase 1	Homo sapiens	56-61
12657639-6	2003	The third SH3 domain of vinexin bound to the region between the second and third PDZ domain of lp-dlg, which contains a proline-rich sequence.	Proline	120-127	sorbin and SH3 domain containing 3	Sus scrofa	24-31
12810669-6	2003	The consequences of the identity of the amino acid at position 198 were investigated by engineering breast carcinoma cells that exclusively express either the leucine- or proline-containing GPx-1 allele and studying the response to increasing concentrations of selenium.	Proline	171-178	glutathione peroxidase 1	Homo sapiens	190-195
12672817-6	2003	The CD2AP-binding site for cortactin mapped to the second of three proline-rich regions.	Proline	67-74	CD2 associated protein	Homo sapiens	4-9
12673672-6	2003	It led to an exchange of an evolutionary conserved proline residue for serine and located within the second CUB domain of DMBT1.	Proline	51-58	deleted in malignant brain tumors 1	Homo sapiens	122-127
12672817-6	2003	The CD2AP-binding site for cortactin mapped to the second of three proline-rich regions.	Proline	67-74	cortactin	Homo sapiens	27-36
12787665-8	2003	Furthermore, a fourth region rich in proline and glutamine residues and with no intrinsic transactivation function, the P/Q domain, appears to play an important role in the FOXJ2-mediated transactivation mechanism.	Proline	37-44	forkhead box J2	Homo sapiens	173-178
12782329-4	2003	When Ala100 of MutL is substituted by proline, mimicking the K(+)-binding environment in BCK, the mutant MutL protein becomes exclusively dependent on Na(+) for the ATPase activity.	Proline	38-45	creatine kinase B	Rattus norvegicus	89-92
12798441-5	2003	Increased TGF-beta(1) transcription and translation were associated with enhanced synthesis of extracellular matrix components including the collagen types I and III as shown by immunocytochemistry and enhanced incorporation of [3H]proline.	Proline	232-239	transforming growth factor beta 1	Homo sapiens	10-21
12773384-4	2003	TCGAP consists of N-terminal PX and SH3 domains, a central Rho GAP domain and multiple proline-rich regions in the C-terminus.	Proline	87-94	Rho GTPase activating protein 33	Homo sapiens	0-5
12853137-6	2003	Two tyrosines that probably bind to the Src Homology 2 (SH2) domains of a tyrosine phosphatase in all Gab family members are conserved at the C-terminal end; two other potential SH2-binding sites in Dos were also identified, as well as several proline rich sequences that might bind to SH3 or EVH1 domains in other proteins.	Proline	244-251	alpha-1-B glycoprotein	Homo sapiens	102-105
12866886-0	2003	Characterisation of the active site of a newly-discovered and potentially significant post-proline cleaving endopeptidase called ZIP using LC-UV-MS.	Proline	91-98	death associated protein kinase 3	Homo sapiens	129-132
12776987-2	2003	SHB is ubiquitously expressed and contains proline rich motifs, a phosphotyrosine binding (PTB) domain, tyrosine phosphorylation sites and an SH2 domain and serves a role in generating signaling complexes in response to tyrosine kinase activation.	Proline	43-50	SH2 domain containing adaptor protein B	Rattus norvegicus	0-3
12796380-8	2003	After adjustment for age and gender, a logistic regression analysis suggested that the risk for a p53 Arg homozygous patient to develop cardia cancer is 3.1 95% confidence interval, 1.4-7.3) times greater than for p53 Pro homozygous and p53 Arg/Pro heterozygous patients.	Proline	218-221	tumor protein p53	Homo sapiens	98-101
12796380-8	2003	After adjustment for age and gender, a logistic regression analysis suggested that the risk for a p53 Arg homozygous patient to develop cardia cancer is 3.1 95% confidence interval, 1.4-7.3) times greater than for p53 Pro homozygous and p53 Arg/Pro heterozygous patients.	Proline	218-221	tumor protein p53	Homo sapiens	214-217
12796380-8	2003	After adjustment for age and gender, a logistic regression analysis suggested that the risk for a p53 Arg homozygous patient to develop cardia cancer is 3.1 95% confidence interval, 1.4-7.3) times greater than for p53 Pro homozygous and p53 Arg/Pro heterozygous patients.	Proline	218-221	tumor protein p53	Homo sapiens	214-217
12877795-8	2003	In a culture medium, CsA (10(-8) - 10(-6) mol/L) inhibited (3)H-proline secretion induced by bFGF in a dose-dependent manner, with the inhibitory rates by 19%, 29% (P &lt; 0.05) and 56% (P &lt; 0.01).	Proline	64-71	fibroblast growth factor 2	Homo sapiens	93-97
12730291-2	2003	The connexin43 C-terminal sequence contains a proline-rich region corresponding to the consensus of a protein-protein interaction PY-motif (xPPxY), and an overlapping putative tyrosine-based sorting signal (Yxxphi; =hydrophobic), known to play a role in the intracellular trafficking of many membrane proteins.	Proline	46-53	gap junction protein alpha 1	Homo sapiens	4-14
12765974-3	2003	A nonsynonymous single nucleotide polymorphism (SNP) (Pro to Thr) in the TCF7 gene, C883A, was examined in samples from 282 Caucasian multiplex type 1 diabetic families.	Proline	54-57	transcription factor 7	Homo sapiens	73-77
12743291-6	2003	Interestingly, an MMuLV-JSRV chimera in which the putative receptor binding domain (RBD) and proline-rich region (PRR) of JSRV Env were replaced by the RBD and PRR of MMuLV induced transformation of 208F, a rodent fibroblast line.	Proline	93-100	envelope protein	Jaagsiekte sheep retrovirus	127-130
12932169-0	2003	Leucine 7 to proline 7 polymorphism of the preproneuropeptide Y gene is not associated with restenosis after coronary stenting.	Proline	13-20	neuropeptide Y	Homo sapiens	43-63
12771423-5	2003	Using site-directed mutagenesis, we showed that a proline residue at position 24 of the GP(5) sequence of the PPV strain enabled recognition by the neutralizing mAbs.	Proline	50-57	glycoprotein V platelet	Homo sapiens	88-93
12766977-0	2003	Respiratory insufficiency in desminopathy patients caused by introduction of proline residues in desmin c-terminal alpha-helical segment.	Proline	77-84	desmin	Homo sapiens	29-35
12766977-4	2003	Novel mutations, A357P and L370P, predicted to introduce proline residue into a highly conserved alpha-helical region of desmin, were identified.	Proline	57-64	desmin	Homo sapiens	121-127
12730686-2	2003	They possess both sequence-specific binding and proline cis-trans isomerase activities, as exemplified by the interaction between cyclophilin A (CypA) and the HIV-1 CA protein.	Proline	48-55	peptidylprolyl isomerase A	Homo sapiens	130-143
12730686-2	2003	They possess both sequence-specific binding and proline cis-trans isomerase activities, as exemplified by the interaction between cyclophilin A (CypA) and the HIV-1 CA protein.	Proline	48-55	peptidylprolyl isomerase A	Homo sapiens	145-149
12730686-3	2003	Here, we report crystal structures of CypA in complex with HIV-1 CA protein variants that bind preferentially with the substrate proline residue in either the cis or the trans conformation.	Proline	129-136	peptidylprolyl isomerase A	Homo sapiens	38-42
12730686-5	2003	CypA Arg55 guanidinium group probably facilitates catalysis by anchoring the substrate proline oxygen and stabilizing sp3 hybridization of the proline nitrogen in the transition state.	Proline	87-94	peptidylprolyl isomerase A	Homo sapiens	0-4
12730686-5	2003	CypA Arg55 guanidinium group probably facilitates catalysis by anchoring the substrate proline oxygen and stabilizing sp3 hybridization of the proline nitrogen in the transition state.	Proline	143-150	peptidylprolyl isomerase A	Homo sapiens	0-4
12783337-8	2003	The inhibitory activity of dehydrin against liposome oxidation was stronger than that of albumin, glutathione, proline, glycine betaine, and sucrose.	Proline	111-118	dehydrin	Glycine max	27-35
12621059-3	2003	This exon is absent from the LDL receptor and contains three proline-rich (PXXP) motifs that may allow apoER2 to function as a signal transducer.	Proline	61-68	LDL receptor related protein 8	Homo sapiens	103-109
12621059-8	2003	Thus features of apoER2 that distinguish it as a signaling receptor, rather than as an endocytosis receptor like the LDL receptor, reside in or near the transmembrane domain and in the proline-rich motifs.	Proline	185-192	LDL receptor related protein 8	Homo sapiens	17-23
12649278-2	2003	In normoxia, PHD hydroxylates a specific proline residue that directs the degradation of constitutively synthesized hypoxia-inducible factor-1alpha.	Proline	41-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-147
12649278-3	2003	During hypoxia, the cessation of hydroxylation of this proline results in less degradation and thus increases hypoxia-inducible factor-1alpha protein levels.	Proline	55-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-141
12727219-6	2003	Functional expression in either mammalian cells or Xenopus laevis oocytes demonstrates that rat PAT2 mediates pH-dependent, Na(+)-independent uptake of glycine, proline, and alpha(methyl)aminoisobutyric acid (MeAIB).	Proline	161-168	solute carrier family 36 member 2	Rattus norvegicus	96-100
12642579-10	2003	Exchanging this proline in Kv2.1 for the corresponding residue of Kv9.3 resulted in channels (Kv2.1-P410T) that show all hallmarks of the regulation of Kv2.1 by Kv9.3.	Proline	16-23	potassium voltage-gated channel subfamily B member 1	Homo sapiens	27-32
12642579-10	2003	Exchanging this proline in Kv2.1 for the corresponding residue of Kv9.3 resulted in channels (Kv2.1-P410T) that show all hallmarks of the regulation of Kv2.1 by Kv9.3.	Proline	16-23	potassium voltage-gated channel modifier subfamily S member 3	Homo sapiens	66-71
12642579-10	2003	Exchanging this proline in Kv2.1 for the corresponding residue of Kv9.3 resulted in channels (Kv2.1-P410T) that show all hallmarks of the regulation of Kv2.1 by Kv9.3.	Proline	16-23	potassium voltage-gated channel subfamily B member 1	Homo sapiens	94-99
12642579-10	2003	Exchanging this proline in Kv2.1 for the corresponding residue of Kv9.3 resulted in channels (Kv2.1-P410T) that show all hallmarks of the regulation of Kv2.1 by Kv9.3.	Proline	16-23	potassium voltage-gated channel subfamily B member 1	Homo sapiens	94-99
12642579-10	2003	Exchanging this proline in Kv2.1 for the corresponding residue of Kv9.3 resulted in channels (Kv2.1-P410T) that show all hallmarks of the regulation of Kv2.1 by Kv9.3.	Proline	16-23	potassium voltage-gated channel modifier subfamily S member 3	Homo sapiens	161-166
12657628-4	2003	Like p47phox, p41 contains an amino-terminal Phox homology domain, two SH3 domains, and a conserved carboxyl-terminal, proline-rich motif.	Proline	119-126	neutrophil cytosolic factor 1	Mus musculus	5-12
12657628-4	2003	Like p47phox, p41 contains an amino-terminal Phox homology domain, two SH3 domains, and a conserved carboxyl-terminal, proline-rich motif.	Proline	119-126	erythrocyte membrane protein band 4.1	Mus musculus	14-17
12609999-0	2003	The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.	Proline	28-35	tumor protein p53	Homo sapiens	84-87
12609999-0	2003	The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.	Proline	28-35	H3 histone pseudogene 16	Homo sapiens	146-149
12618429-7	2003	The tandem SH3 domains of p47(phox) were found to associate with a proline-rich mid-region of RelA (RelA-PR) located between the Rel homology and transactivation domains.	Proline	67-74	pleckstrin	Homo sapiens	26-29
12609999-0	2003	The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.	Proline	28-35	E1A binding protein p300	Homo sapiens	180-184
12618429-7	2003	The tandem SH3 domains of p47(phox) were found to associate with a proline-rich mid-region of RelA (RelA-PR) located between the Rel homology and transactivation domains.	Proline	67-74	RELA proto-oncogene, NF-kB subunit	Homo sapiens	94-98
12618429-7	2003	The tandem SH3 domains of p47(phox) were found to associate with a proline-rich mid-region of RelA (RelA-PR) located between the Rel homology and transactivation domains.	Proline	67-74	RELA proto-oncogene, NF-kB subunit	Homo sapiens	100-107
12609999-0	2003	The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.	Proline	28-35	CREB binding protein	Homo sapiens	185-205
12624093-2	2003	SAPK/JNK activation requires the phosphorylation of both Thr and Tyr residues in its Thr-Pro-Tyr motif, and SEK1 and MKK7 have been identified as the dual specificity kinases.	Proline	89-92	mitogen-activated protein kinase 8	Homo sapiens	5-8
12609999-1	2003	The p53 transcription factor contains two separate tandem activation domains (AD1 and AD2), a proline-rich domain (PRD), and a C-terminal basic domain (BD).	Proline	94-101	tumor protein p53	Homo sapiens	4-7
12624093-7	2003	Analysis in human embryonic kidney 293T cells transfected with a kinase-dead SEK1 or a Thr-Pro-Phe mutant of JNK1 revealed that SEK1-induced Tyr phosphorylation of JNK1 was followed by additional Thr phosphorylation by MKK7.	Proline	91-94	mitogen-activated protein kinase 8	Homo sapiens	109-113
12743601-6	2003	Tumor-associated p53 mutants however are attenuated for YB1 nuclear localization as are mutants mutated in the proline-rich domain of p53.	Proline	111-118	tumor protein p53	Homo sapiens	17-20
12624093-7	2003	Analysis in human embryonic kidney 293T cells transfected with a kinase-dead SEK1 or a Thr-Pro-Phe mutant of JNK1 revealed that SEK1-induced Tyr phosphorylation of JNK1 was followed by additional Thr phosphorylation by MKK7.	Proline	91-94	mitogen-activated protein kinase kinase 4	Homo sapiens	128-132
12624093-7	2003	Analysis in human embryonic kidney 293T cells transfected with a kinase-dead SEK1 or a Thr-Pro-Phe mutant of JNK1 revealed that SEK1-induced Tyr phosphorylation of JNK1 was followed by additional Thr phosphorylation by MKK7.	Proline	91-94	mitogen-activated protein kinase 8	Homo sapiens	164-168
12743601-6	2003	Tumor-associated p53 mutants however are attenuated for YB1 nuclear localization as are mutants mutated in the proline-rich domain of p53.	Proline	111-118	Y-box binding protein 1	Homo sapiens	56-59
12743601-6	2003	Tumor-associated p53 mutants however are attenuated for YB1 nuclear localization as are mutants mutated in the proline-rich domain of p53.	Proline	111-118	tumor protein p53	Homo sapiens	134-137
12600984-0	2003	Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation.	Proline	41-48	SRC proto-oncogene, non-receptor tyrosine kinase	Canis lupus familiaris	20-23
12591923-8	2003	STAT1 preferentially binds peptides with the motif phosphotyrosine-(aspartic acid/glutamic acid)-(proline/arginine)-(arginine/proline/glutamine), whereby a negatively charged amino acid at +1 excludes a proline at +2 and vice versa.	Proline	98-105	signal transducer and activator of transcription 1	Mus musculus	0-5
12591923-8	2003	STAT1 preferentially binds peptides with the motif phosphotyrosine-(aspartic acid/glutamic acid)-(proline/arginine)-(arginine/proline/glutamine), whereby a negatively charged amino acid at +1 excludes a proline at +2 and vice versa.	Proline	126-133	signal transducer and activator of transcription 1	Mus musculus	0-5
12591923-8	2003	STAT1 preferentially binds peptides with the motif phosphotyrosine-(aspartic acid/glutamic acid)-(proline/arginine)-(arginine/proline/glutamine), whereby a negatively charged amino acid at +1 excludes a proline at +2 and vice versa.	Proline	126-133	signal transducer and activator of transcription 1	Mus musculus	0-5
12591923-9	2003	STAT3 preferentially binds peptides with the motif phosphotyrosine-(basic or hydrophobic)-(proline or basic)-glutamine.	Proline	91-98	signal transducer and activator of transcription 3	Mus musculus	0-5
12586835-4	2003	In mitotic HeLa cells, when the activity of Cdc2 is high, S6K1 is phosphorylated at multiple Ser/Thr, Pro (S/TP) sites, including Ser(371), Ser(411), Thr(421), and Ser(424).	Proline	102-105	cyclin dependent kinase 1	Homo sapiens	44-48
12586835-4	2003	In mitotic HeLa cells, when the activity of Cdc2 is high, S6K1 is phosphorylated at multiple Ser/Thr, Pro (S/TP) sites, including Ser(371), Ser(411), Thr(421), and Ser(424).	Proline	102-105	ribosomal protein S6 kinase B1	Homo sapiens	58-62
12586835-7	2003	These proline-directed phosphorylations are sensitive to chemical inhibitors of Cdc2 but not to inhibitors of mammalian target of rapamycin, phosphatidylinositol 3-kinase, MEK1/2, or p38.	Proline	6-13	cyclin dependent kinase 1	Homo sapiens	80-84
12586835-7	2003	These proline-directed phosphorylations are sensitive to chemical inhibitors of Cdc2 but not to inhibitors of mammalian target of rapamycin, phosphatidylinositol 3-kinase, MEK1/2, or p38.	Proline	6-13	mitogen-activated protein kinase 14	Homo sapiens	183-186
12600984-0	2003	Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation.	Proline	41-48	AKT serine/threonine kinase 1	Homo sapiens	63-66
12600984-0	2003	Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation.	Proline	41-48	AKT serine/threonine kinase 1	Homo sapiens	83-86
12600984-2	2003	Here, we provide evidence that tyrosine kinase Src is directly associated with Akt through the interaction between its SH3 domain and a conserved proline-rich motif (PXXP) in the C-terminal regulatory region of Akt.	Proline	146-153	SRC proto-oncogene, non-receptor tyrosine kinase	Canis lupus familiaris	47-50
12600984-2	2003	Here, we provide evidence that tyrosine kinase Src is directly associated with Akt through the interaction between its SH3 domain and a conserved proline-rich motif (PXXP) in the C-terminal regulatory region of Akt.	Proline	146-153	AKT serine/threonine kinase 1	Homo sapiens	79-82
12600984-2	2003	Here, we provide evidence that tyrosine kinase Src is directly associated with Akt through the interaction between its SH3 domain and a conserved proline-rich motif (PXXP) in the C-terminal regulatory region of Akt.	Proline	146-153	AKT serine/threonine kinase 1	Homo sapiens	211-214
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	20-27	AKT serine/threonine kinase 1	Homo sapiens	88-91
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	20-27	epidermal growth factor	Canis lupus familiaris	136-159
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	20-27	epidermal growth factor	Canis lupus familiaris	161-164
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	20-27	AKT serine/threonine kinase 1	Homo sapiens	232-235
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	20-27	SRC proto-oncogene, non-receptor tyrosine kinase	Canis lupus familiaris	258-261
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	37-40	AKT serine/threonine kinase 1	Homo sapiens	88-91
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	37-40	epidermal growth factor	Canis lupus familiaris	136-159
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	37-40	epidermal growth factor	Canis lupus familiaris	161-164
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	37-40	AKT serine/threonine kinase 1	Homo sapiens	232-235
12687659-8	2003	In this report, we describe the first non-Jewish IKBKAP mutation, a proline to leucine missense mutation in exon 26, P914L.	Proline	68-75	elongator acetyltransferase complex subunit 1	Homo sapiens	49-55
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	37-40	SRC proto-oncogene, non-receptor tyrosine kinase	Canis lupus familiaris	258-261
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	49-52	AKT serine/threonine kinase 1	Homo sapiens	88-91
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	49-52	epidermal growth factor	Canis lupus familiaris	136-159
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	49-52	epidermal growth factor	Canis lupus familiaris	161-164
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	49-52	AKT serine/threonine kinase 1	Homo sapiens	232-235
12600984-3	2003	Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src.	Proline	49-52	SRC proto-oncogene, non-receptor tyrosine kinase	Canis lupus familiaris	258-261
12600984-5	2003	We also showed that phosphorylation of Tyr-315 in Akt induced by Src or EGF is dependent on the integrity of this proline-rich motif.	Proline	114-121	AKT serine/threonine kinase 1	Homo sapiens	50-53
12600984-5	2003	We also showed that phosphorylation of Tyr-315 in Akt induced by Src or EGF is dependent on the integrity of this proline-rich motif.	Proline	114-121	SRC proto-oncogene, non-receptor tyrosine kinase	Canis lupus familiaris	65-68
12600984-5	2003	We also showed that phosphorylation of Tyr-315 in Akt induced by Src or EGF is dependent on the integrity of this proline-rich motif.	Proline	114-121	epidermal growth factor	Canis lupus familiaris	72-75
12600984-6	2003	Furthermore, the Akt mutant lacking this proline motif fails to block the transcription activity of Forkhead in 293 cells and poorly stimulates the proliferation of Madin-Darby canine kidney cells.	Proline	41-48	AKT serine/threonine kinase 1	Homo sapiens	17-20
12600984-7	2003	Taken together, our data suggest that the interaction between the SH3 domain of Src family kinases and the proline-rich motif in the C-terminal regulatory region of Akt is required for tyrosine phosphorylation of Akt and its subsequent activation.	Proline	107-114	SRC proto-oncogene, non-receptor tyrosine kinase	Canis lupus familiaris	80-83
12600984-7	2003	Taken together, our data suggest that the interaction between the SH3 domain of Src family kinases and the proline-rich motif in the C-terminal regulatory region of Akt is required for tyrosine phosphorylation of Akt and its subsequent activation.	Proline	107-114	AKT serine/threonine kinase 1	Homo sapiens	165-168
12600984-7	2003	Taken together, our data suggest that the interaction between the SH3 domain of Src family kinases and the proline-rich motif in the C-terminal regulatory region of Akt is required for tyrosine phosphorylation of Akt and its subsequent activation.	Proline	107-114	AKT serine/threonine kinase 1	Homo sapiens	213-216
12716762-6	2003	After adjusting for sex, age, and BMI, adult subjects with the genotype Pro/Pro, Pro/Ala, and Ala/Ala, respectively, showed significant decreasing trends in fasting insulin (11.7, 10.3, and 8.8 micro U/ml; P = 0.002) and HOMA-IR (2.4, 2.1, and 1.7; P = 0.006).	Proline	72-75	insulin	Homo sapiens	165-172
12663371-0	2003	Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction.	Proline	12-19	peroxisome proliferator activated receptor gamma	Homo sapiens	40-90
12663371-0	2003	Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction.	Proline	12-19	peroxisome proliferator activated receptor gamma	Homo sapiens	92-98
12663371-2	2003	A common alanine (A) for proline (P) substitution at codon 12 in the peroxisome proliferator activated receptor gamma-2 gene (PPARG2) has been associated with reduced risk of developing type 2 diabetes mellitus.	Proline	25-32	peroxisome proliferator activated receptor gamma	Homo sapiens	69-119
12663371-2	2003	A common alanine (A) for proline (P) substitution at codon 12 in the peroxisome proliferator activated receptor gamma-2 gene (PPARG2) has been associated with reduced risk of developing type 2 diabetes mellitus.	Proline	25-32	peroxisome proliferator activated receptor gamma	Homo sapiens	126-132
12834837-2	2003	The investigation, designed to detect substrate-mediated isomerization of pyruvate kinase, has revealed a 15% enhancement of maximal velocity by supplementation of reaction mixtures with 0.1 M proline, glycine or sorbitol.	Proline	193-200	pyruvate kinase PKLR	Oryctolagus cuniculus	74-89
12684648-2	2003	A sequence polymorphism at codon 72 of the p53 gene results in either a proline or an arginine and may induce different functional activities.	Proline	72-79	tumor protein p53	Homo sapiens	43-46
12742553-3	2003	The elk pre-PRL cDNA exhibits two polymorphisms at positions 96 and 672, which are silent since they encode for the same amino acids, proline and isoleucine, respectively.	Proline	134-141	prolactin	Equus caballus	12-15
12697679-2	2003	The SGEF mRNA is widely expressed in human tissues, and the predicted 871-amino acid SGEF protein contains Dbl homology and pleckstrin homology domains as well as an N-terminal proline-rich domain, a C-terminal Src homology 3 domain, and two nuclear localization signals.	Proline	177-184	Rho guanine nucleotide exchange factor 26	Homo sapiens	85-89
12757746-3	2003	This activity was shown to be associated with the proline-lysine-proline motif, which is responsible for the induction of mast cell degranulation by the mammalian bioactive peptide substance P.	Proline	50-57	tachykinin precursor 1	Homo sapiens	181-192
12757746-3	2003	This activity was shown to be associated with the proline-lysine-proline motif, which is responsible for the induction of mast cell degranulation by the mammalian bioactive peptide substance P.	Proline	65-72	tachykinin precursor 1	Homo sapiens	181-192
12877331-1	2003	Zein is a hydrophobic corn protein, rich in leucine, proline and alanine, that has has previously been investigated as a potential excipient in pharmaceutical manufacturing.	Proline	53-60	zein	Zea mays	0-4
12586829-14	2003	We conclude that CsA destabilizes HIF-1alpha by promoting hydroxylation of Pro-564 in the ODD domain.	Proline	75-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
12773641-0	2003	Toxicity of free proline revealed in an arabidopsis T-DNA-tagged mutant deficient in proline dehydrogenase.	Proline	17-24	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	85-106
12914288-4	2003	The sequence of human liver glutathione-S-transferase M1 gene was verified to be correctly recombined with pBV220 compared with the same sequence in Gene Bank, and code 619 C--&gt;A, the amino acid changed from Pro to Thr was observed.	Proline	211-214	glutathione S-transferase mu 1	Homo sapiens	28-56
12569093-4	2003	The results show that the c-Abl SH3 domain binds directly to a proline-rich site (amino acids 567-576) in the Arg C-terminal region.	Proline	63-70	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	26-31
12693945-8	2003	Aib provides an attractive alternative to proline and other substitutions in producing peptide variants with a lower tendency to produce fibril aggregates.	Proline	42-49	ANIB1	Homo sapiens	0-3
12576483-6	2003	The proline-rich regions in the C-terminal half of Pyk2 bind to the SH3 domain of PSD-95 and SAP102.	Proline	4-11	protein tyrosine kinase 2 beta	Homo sapiens	51-55
12576483-6	2003	The proline-rich regions in the C-terminal half of Pyk2 bind to the SH3 domain of PSD-95 and SAP102.	Proline	4-11	discs large MAGUK scaffold protein 4	Homo sapiens	82-88
12576483-6	2003	The proline-rich regions in the C-terminal half of Pyk2 bind to the SH3 domain of PSD-95 and SAP102.	Proline	4-11	discs large MAGUK scaffold protein 3	Homo sapiens	93-99
12688731-1	2003	[structure: see text] The first computational studies to elucidate the stereoselectivity of the proline-catalyzed direct Mannich reaction have been performed using density functional theory (B3LYP/6-31G*).	Proline	96-103	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	193-196
12529175-3	2003	Two other proline-specific dipeptidases, DPP-VII (also known as quiescent cell proline dipeptidase) and DPP-II, have unknown functions and have recently been suggested to be identical proteases based on a sequence comparison of human DPP-VII and rat DPP-II (78% identity) [Araki, Li, Yamamoto, Haneda, Nishi, Kikkawa and Ohkubo (2001) J. Biochem.	Proline	10-17	dipeptidyl peptidase 7	Homo sapiens	64-98
12529175-3	2003	Two other proline-specific dipeptidases, DPP-VII (also known as quiescent cell proline dipeptidase) and DPP-II, have unknown functions and have recently been suggested to be identical proteases based on a sequence comparison of human DPP-VII and rat DPP-II (78% identity) [Araki, Li, Yamamoto, Haneda, Nishi, Kikkawa and Ohkubo (2001) J. Biochem.	Proline	10-17	dipeptidyl peptidase 7	Homo sapiens	104-110
12529175-3	2003	Two other proline-specific dipeptidases, DPP-VII (also known as quiescent cell proline dipeptidase) and DPP-II, have unknown functions and have recently been suggested to be identical proteases based on a sequence comparison of human DPP-VII and rat DPP-II (78% identity) [Araki, Li, Yamamoto, Haneda, Nishi, Kikkawa and Ohkubo (2001) J. Biochem.	Proline	10-17	dipeptidylpeptidase 7	Rattus norvegicus	250-256
12670503-1	2003	Three HIF-alpha prolyl-4-hydroxylases (PHDs) (named PHD1, PHD2, and PHD3) effect the proteasome-mediated degradation of HIF by catalyzing the hydroxylation of key proline residues in the HIF-1 alpha subunit under normoxic conditions.	Proline	163-170	egl-9 family hypoxia inducible factor 2	Homo sapiens	52-56
12670503-1	2003	Three HIF-alpha prolyl-4-hydroxylases (PHDs) (named PHD1, PHD2, and PHD3) effect the proteasome-mediated degradation of HIF by catalyzing the hydroxylation of key proline residues in the HIF-1 alpha subunit under normoxic conditions.	Proline	163-170	egl-9 family hypoxia inducible factor 1	Homo sapiens	58-62
12670503-1	2003	Three HIF-alpha prolyl-4-hydroxylases (PHDs) (named PHD1, PHD2, and PHD3) effect the proteasome-mediated degradation of HIF by catalyzing the hydroxylation of key proline residues in the HIF-1 alpha subunit under normoxic conditions.	Proline	163-170	egl-9 family hypoxia inducible factor 3	Homo sapiens	68-72
12670503-1	2003	Three HIF-alpha prolyl-4-hydroxylases (PHDs) (named PHD1, PHD2, and PHD3) effect the proteasome-mediated degradation of HIF by catalyzing the hydroxylation of key proline residues in the HIF-1 alpha subunit under normoxic conditions.	Proline	163-170	hypoxia inducible factor 1 subunit alpha	Homo sapiens	187-198
12496242-4	2003	In a yeast two-hybrid search of a human placental library, using as bait repeats 10-18 of filamin B, we isolated a cDNA coding for a novel 374 amino acid protein containing a proline-rich domain near its N terminus and two LIM domains at its C terminus.	Proline	175-182	filamin B	Homo sapiens	90-99
12676352-1	2003	The YIPP (tyrosine-isoleucine-proline-proline, amino acids 319-322) motif within the C-terminal part of the human AT(1) receptor is associated with angiotensin II (AII)-induced activation of the Jak-STAT pathway and phospholipase Cgamma1 phosphorylation.	Proline	30-37	angiotensinogen	Homo sapiens	148-162
12676352-1	2003	The YIPP (tyrosine-isoleucine-proline-proline, amino acids 319-322) motif within the C-terminal part of the human AT(1) receptor is associated with angiotensin II (AII)-induced activation of the Jak-STAT pathway and phospholipase Cgamma1 phosphorylation.	Proline	30-37	angiotensinogen	Homo sapiens	164-167
12676352-1	2003	The YIPP (tyrosine-isoleucine-proline-proline, amino acids 319-322) motif within the C-terminal part of the human AT(1) receptor is associated with angiotensin II (AII)-induced activation of the Jak-STAT pathway and phospholipase Cgamma1 phosphorylation.	Proline	38-45	angiotensinogen	Homo sapiens	148-162
12676352-1	2003	The YIPP (tyrosine-isoleucine-proline-proline, amino acids 319-322) motif within the C-terminal part of the human AT(1) receptor is associated with angiotensin II (AII)-induced activation of the Jak-STAT pathway and phospholipase Cgamma1 phosphorylation.	Proline	38-45	angiotensinogen	Homo sapiens	164-167
12540840-13	2003	Using a combination of partial proteolysis, GST fusion protein expression, and mutation of residues that differ between rat and human SERCA3, we have identified human SERCA3 amino acids Pro(8) and Glu(192) as essential to forming the PL/IM430 epitope.	Proline	186-189	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	167-173
12605438-3	2003	These two families revealed missense mutations consisting of a glutamic acid substitution for lysine and a proline substitution for leucine within the paired domain of PAX9.	Proline	107-114	paired box 9	Homo sapiens	168-172
12648751-2	2003	We performed a case-control association study between sporadic AD and the common proline/arginine polymorphism at codon 72 in the pro-apoptotic gene p53, in 109 sporadic AD patients and in 111 controls.	Proline	81-88	tumor protein p53	Homo sapiens	149-152
12446441-5	2003	We show here that the introduction of a proline residue in the alpha 4 (Ala152Pro) or beta 5 (Leu130Pro) loop, observed in 2 of these spontaneous mutants, dramatically affects both guanosine triphosphate (GTP) and guanosine diphosphate (GDP) nucleotide-binding activity of Rab27a, probably by disrupting protein folding.	Proline	40-47	RAB27A, member RAS oncogene family	Homo sapiens	273-279
12646039-8	2003	Conversion of this glutamic acid residue into proline in RHA2a decreased its ability to interact with ANAC, most likely by changing the interaction surface.	Proline	46-53	RING-H2 finger A2A	Arabidopsis thaliana	57-62
12540842-1	2003	As a c-fms-interacting protein, we cloned a novel adaptor molecule, signal-transducing adaptor protein-2 (STAP-2), which contains pleckstrin homology- and Src homology 2-like (PH and SRC) domains and a proline-rich region.	Proline	202-209	signal transducing adaptor family member 2	Mus musculus	68-104
12726864-3	2003	A polymorphism encoding either arginine (72R) or proline (72P) at codon 72 of p53 influences inhibition of p73 by a range of p53 mutants identified in squamous cancers.	Proline	49-56	tumor protein p53	Homo sapiens	78-81
12726864-3	2003	A polymorphism encoding either arginine (72R) or proline (72P) at codon 72 of p53 influences inhibition of p73 by a range of p53 mutants identified in squamous cancers.	Proline	49-56	tumor protein p73	Homo sapiens	107-110
12726864-3	2003	A polymorphism encoding either arginine (72R) or proline (72P) at codon 72 of p53 influences inhibition of p73 by a range of p53 mutants identified in squamous cancers.	Proline	49-56	tumor protein p53	Homo sapiens	125-128
12686590-3	2003	Inp53p contains a SacI polyphosphoinositide phosphatase domain, a 5-phosphatase domain, and a proline-rich domain.	Proline	94-101	phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53	Saccharomyces cerevisiae S288C	0-6
12686590-6	2003	The proline-rich domain was shown to bind to two proteins, including clathrin heavy chain, Chc1p.	Proline	4-11	clathrin heavy chain	Saccharomyces cerevisiae S288C	91-96
12641734-3	2003	In the present study, we isolated CIP98, a novel protein (98 kDa) consisting of three PDZ domains and a proline-rich region, which is widely expressed in the central nervous system.	Proline	104-111	whirlin	Homo sapiens	34-39
12686424-8	2003	These accumulated sequence mutations among the eight HBx variants were found to coincide within the B-cell epitopes (positions 29-48), particularly in the HBx proline and serine rich (PSR) domain, and the T-cell epitopes regions (positions 116-127).	Proline	159-166	X protein	Hepatitis B virus	53-56
12686424-8	2003	These accumulated sequence mutations among the eight HBx variants were found to coincide within the B-cell epitopes (positions 29-48), particularly in the HBx proline and serine rich (PSR) domain, and the T-cell epitopes regions (positions 116-127).	Proline	159-166	X protein	Hepatitis B virus	155-158
12538644-3	2003	This process is dependent on the hydroxylation of conserved proline residues on the alpha subunits of HIF-1/2 in the presence of oxygen.	Proline	60-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-109
12540842-1	2003	As a c-fms-interacting protein, we cloned a novel adaptor molecule, signal-transducing adaptor protein-2 (STAP-2), which contains pleckstrin homology- and Src homology 2-like (PH and SRC) domains and a proline-rich region.	Proline	202-209	signal transducing adaptor family member 2	Mus musculus	106-112
12651028-4	2003	The tubulin binding domain could be confined to a proline-rich segment (amino acids 371-412) of the P2X(2) subunit.	Proline	50-57	purinergic receptor P2X 2	Rattus norvegicus	100-106
12646027-2	2003	The thrombin inhibitory tripeptide d-Phe-Pro-Arg has been mimicked using either cyclopentenedicarboxylic derivatives or a cyclohexenedicarboxylic derivative as surrogate for the P2 proline.	Proline	181-188	coagulation factor II, thrombin	Homo sapiens	4-12
12650996-2	2003	The PRH protein contains a proline-rich N-terminal domain that can repress transcription when attached to a heterologous DNA binding domain, a central homeodomain that mediates sequence-specific DNA binding, and an acidic C-terminal domain of unknown function.	Proline	27-34	hematopoietically expressed homeobox	Homo sapiens	4-7
12524439-0	2003	Identification of a proline-rich Akt substrate as a 14-3-3 binding partner.	Proline	20-27	AKT serine/threonine kinase 1	Homo sapiens	33-36
12514190-5	2003	GBP encoded 1021 amino acids and was predicted to have two transmembrane regions and glutamic acid- and proline-rich regions.	Proline	104-111	transmembrane protein 132A	Rattus norvegicus	0-3
12524439-5	2003	This 40-kDa protein, designated PRAS40, is a proline-rich Akt substrate.	Proline	45-52	AKT1 substrate 1	Homo sapiens	32-38
12524439-5	2003	This 40-kDa protein, designated PRAS40, is a proline-rich Akt substrate.	Proline	45-52	AKT serine/threonine kinase 1	Homo sapiens	58-61
12604794-5	2003	In agreement with the computational model, we show biochemical evidence that pVHL specifically binds the hyperphosphorylated Rpb1 in a proline-hydroxylation-dependent manner, targeting it for ubiquitination.	Proline	135-142	von Hippel-Lindau tumor suppressor	Homo sapiens	77-81
12522133-4	2003	We identify the site of this interaction as the second proline-rich SH3 binding domain of PAK1.	Proline	55-62	p21 (RAC1) activated kinase 1	Homo sapiens	90-94
12522133-6	2003	A cell-permeant TAT-tagged peptide encompassing the second proline-rich SH3 binding domain of PAK1 simultaneously blocked Grb2 and activated EGFR association with PAK1, in vitro and in vivo, indicating that Grb2 mediates the interaction of PAK1 with the activated EGFR.	Proline	59-66	p21 (RAC1) activated kinase 1	Homo sapiens	94-98
12522133-6	2003	A cell-permeant TAT-tagged peptide encompassing the second proline-rich SH3 binding domain of PAK1 simultaneously blocked Grb2 and activated EGFR association with PAK1, in vitro and in vivo, indicating that Grb2 mediates the interaction of PAK1 with the activated EGFR.	Proline	59-66	growth factor receptor bound protein 2	Homo sapiens	122-126
12522133-6	2003	A cell-permeant TAT-tagged peptide encompassing the second proline-rich SH3 binding domain of PAK1 simultaneously blocked Grb2 and activated EGFR association with PAK1, in vitro and in vivo, indicating that Grb2 mediates the interaction of PAK1 with the activated EGFR.	Proline	59-66	epidermal growth factor receptor	Homo sapiens	141-145
12522133-6	2003	A cell-permeant TAT-tagged peptide encompassing the second proline-rich SH3 binding domain of PAK1 simultaneously blocked Grb2 and activated EGFR association with PAK1, in vitro and in vivo, indicating that Grb2 mediates the interaction of PAK1 with the activated EGFR.	Proline	59-66	p21 (RAC1) activated kinase 1	Homo sapiens	163-167
12522133-6	2003	A cell-permeant TAT-tagged peptide encompassing the second proline-rich SH3 binding domain of PAK1 simultaneously blocked Grb2 and activated EGFR association with PAK1, in vitro and in vivo, indicating that Grb2 mediates the interaction of PAK1 with the activated EGFR.	Proline	59-66	growth factor receptor bound protein 2	Homo sapiens	207-211
12522133-6	2003	A cell-permeant TAT-tagged peptide encompassing the second proline-rich SH3 binding domain of PAK1 simultaneously blocked Grb2 and activated EGFR association with PAK1, in vitro and in vivo, indicating that Grb2 mediates the interaction of PAK1 with the activated EGFR.	Proline	59-66	p21 (RAC1) activated kinase 1	Homo sapiens	163-167
12482850-5	2003	Crp activating proteolysis at S58 downward arrow L59 was unaffected by I44S/I44D or L54S/L54D loss-of-function mutations in pro-Crp4, and a (L59S)-pro-CC mutant was cleaved normally at Ser(43) downward arrow Val(44) and Ser(53) downward arrow Leu(54) sites but not at the peptide NH(2) terminus.	Proline	15-18	C-reactive protein, pentraxin-related	Mus musculus	0-3
12604794-5	2003	In agreement with the computational model, we show biochemical evidence that pVHL specifically binds the hyperphosphorylated Rpb1 in a proline-hydroxylation-dependent manner, targeting it for ubiquitination.	Proline	135-142	RNA polymerase II subunit A	Homo sapiens	125-129
12595464-2	2003	Recombinant IgA1 antibodies were generated with point mutations at proline 227 and threonine 228, the residues lying on either side of the peptide bond at which all streptococcal IgA1 proteases cleave wild-type human IgA1.	Proline	67-74	immunoglobulin heavy constant alpha 1	Homo sapiens	12-16
12628383-3	2003	Approximately 80% of the amino acids in BMCPA were composed of Ser, Ala, Gly, Pro, Val and Tyr.	Proline	78-81	cuticular protein glycine-rich 4	Bombyx mori	40-45
12628849-2	2003	A common polymorphism at codon 72 of exon 4 encoding either arginine (Arg) or proline (Pro) has been shown to affect HPV-mediated degradation of p53 in vitro, and may represent a risk factor for HPV-induced carcinogenesis.	Proline	78-85	tumor protein p53	Homo sapiens	145-148
12628849-2	2003	A common polymorphism at codon 72 of exon 4 encoding either arginine (Arg) or proline (Pro) has been shown to affect HPV-mediated degradation of p53 in vitro, and may represent a risk factor for HPV-induced carcinogenesis.	Proline	87-90	tumor protein p53	Homo sapiens	145-148
12634853-6	2003	The interacting domains were mapped to the proline-rich region of GBF1 and the head region of p115.	Proline	43-50	golgi brefeldin A resistant guanine nucleotide exchange factor 1	Homo sapiens	66-70
12595464-6	2003	By contrast, the IgA1 proteases of Streptococcus oralis, Streptococcus sanguis, and Streptococcus mitis had an absolute requirement for proline at 227 but not for threonine at 228, which could be replaced by valine.	Proline	136-143	immunoglobulin heavy constant alpha 1	Homo sapiens	17-21
12618476-2	2003	CD2BP3 is the major RNA splice variant of the CIN85 locus in human T lymphocytes, lacking SH3A, the first of three SH3 domains found in CIN85, but retaining SH3B, SH3C, a proline-rich domain and C-terminal coiled coil.	Proline	171-178	SH3 domain containing kinase binding protein 1	Homo sapiens	0-6
12618476-2	2003	CD2BP3 is the major RNA splice variant of the CIN85 locus in human T lymphocytes, lacking SH3A, the first of three SH3 domains found in CIN85, but retaining SH3B, SH3C, a proline-rich domain and C-terminal coiled coil.	Proline	171-178	SH3 domain containing kinase binding protein 1	Homo sapiens	46-51
12618476-6	2003	CIN85 SH3A and CIN85/CD2BP3 SH3B bind to proline-rich segments within CIN85/CD2BP3 themselves as evidenced by mAb accessibility analysis and protein interaction studies including c-Cbl binding.	Proline	41-48	SH3 domain containing kinase binding protein 1	Homo sapiens	0-5
12618476-6	2003	CIN85 SH3A and CIN85/CD2BP3 SH3B bind to proline-rich segments within CIN85/CD2BP3 themselves as evidenced by mAb accessibility analysis and protein interaction studies including c-Cbl binding.	Proline	41-48	SH3 domain containing kinase binding protein 1	Homo sapiens	15-20
12618476-6	2003	CIN85 SH3A and CIN85/CD2BP3 SH3B bind to proline-rich segments within CIN85/CD2BP3 themselves as evidenced by mAb accessibility analysis and protein interaction studies including c-Cbl binding.	Proline	41-48	SH3 domain containing kinase binding protein 1	Homo sapiens	21-27
12571275-2	2003	The phosphorylated Ser/Thr-Pro motifs in a certain subset of phosphoproteins are isomerized specifically by the peptidyl-prolyl cis-trans isomerase Pin1.	Proline	27-30	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	148-152
12618476-6	2003	CIN85 SH3A and CIN85/CD2BP3 SH3B bind to proline-rich segments within CIN85/CD2BP3 themselves as evidenced by mAb accessibility analysis and protein interaction studies including c-Cbl binding.	Proline	41-48	SH3 domain containing kinase binding protein 1	Homo sapiens	15-20
12618476-6	2003	CIN85 SH3A and CIN85/CD2BP3 SH3B bind to proline-rich segments within CIN85/CD2BP3 themselves as evidenced by mAb accessibility analysis and protein interaction studies including c-Cbl binding.	Proline	41-48	SH3 domain containing kinase binding protein 1	Homo sapiens	76-82
12618476-6	2003	CIN85 SH3A and CIN85/CD2BP3 SH3B bind to proline-rich segments within CIN85/CD2BP3 themselves as evidenced by mAb accessibility analysis and protein interaction studies including c-Cbl binding.	Proline	41-48	Cbl proto-oncogene	Homo sapiens	179-184
12588984-4	2003	We show that both PalA and AIP1/Alix recognize a protein-protein binding motif that we denote YPXL/I, where Tyr, Pro, and Leu/Ile are crucial for its interactive properties.	Proline	113-116	programmed cell death 6 interacting protein	Homo sapiens	27-31
12604805-4	2003	Mutational analysis revealed that complex formation is primarily mediated by a proline-rich region in the C-terminal part of NS5A, which interacts with the amphiphysin II Src homology 3 domain.	Proline	79-86	bridging integrator 1	Homo sapiens	156-170
12612073-4	2003	ERID-I and ERID-II flank a proline cluster responsible for binding of PRB to c-Src.	Proline	27-34	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	77-82
12588984-4	2003	We show that both PalA and AIP1/Alix recognize a protein-protein binding motif that we denote YPXL/I, where Tyr, Pro, and Leu/Ile are crucial for its interactive properties.	Proline	113-116	programmed cell death 6 interacting protein	Homo sapiens	32-36
12603084-1	2003	In the present study we investigated the in vivo and in vitro effect of proline (Pro) on acetylcholinesterase (AChE) activity in rat cerebral cortex.	Proline	72-79	acetylcholinesterase	Rattus norvegicus	111-115
12567188-1	2003	The gene TP53, encoding p53, has a common sequence polymorphism that results in either proline or arginine at amino-acid position 72.	Proline	87-94	tumor protein p53	Homo sapiens	9-13
12567188-1	2003	The gene TP53, encoding p53, has a common sequence polymorphism that results in either proline or arginine at amino-acid position 72.	Proline	87-94	tumor protein p53	Homo sapiens	24-27
12567188-2	2003	This polymorphism occurs in the proline-rich domain of p53, which is necessary for the protein to fully induce apoptosis.	Proline	32-39	tumor protein p53	Homo sapiens	55-58
12609505-8	2003	Both patients presented a novel splicing mutation (IVS1-1G--&gt;A) affecting the exon encoding the proline-rich attachment domain (PRAD), which interacts with acetylcholinesterase.	Proline	99-106	acetylcholinesterase (Cartwright blood group)	Homo sapiens	159-179
12468553-2	2003	Binding of pVHL to HIF-1alpha is dependent on hydroxylation of specific proline residues by O(2)-dependent prolyl 4-hydroxylases.	Proline	72-79	von Hippel-Lindau tumor suppressor	Mus musculus	11-15
12621550-4	2003	By observing their subcellular localization, it was found that the three zinc fingers of hBKLF and the N-terminal aside from the fingers all served as nuclear localization signals (NLS); the sub-NLS of hBKLF was located in the N-terminus, including the CtBP-binding motif and the proline rich domain.	Proline	280-287	Kruppel like factor 3	Homo sapiens	202-207
12468553-2	2003	Binding of pVHL to HIF-1alpha is dependent on hydroxylation of specific proline residues by O(2)-dependent prolyl 4-hydroxylases.	Proline	72-79	hypoxia inducible factor 1, alpha subunit	Mus musculus	19-29
12468553-4	2003	One of the two critical proline residues, Pro(563) in mouse HIF-1alpha, is located within a bifunctional domain, the N-terminal transactivation domain (N-TAD), which mediates both pVHL-dependent degradation at normoxia and transcriptional activation at hypoxia.	Proline	24-31	hypoxia inducible factor 1, alpha subunit	Mus musculus	60-70
12468553-4	2003	One of the two critical proline residues, Pro(563) in mouse HIF-1alpha, is located within a bifunctional domain, the N-terminal transactivation domain (N-TAD), which mediates both pVHL-dependent degradation at normoxia and transcriptional activation at hypoxia.	Proline	24-31	von Hippel-Lindau tumor suppressor	Mus musculus	180-184
12468553-4	2003	One of the two critical proline residues, Pro(563) in mouse HIF-1alpha, is located within a bifunctional domain, the N-terminal transactivation domain (N-TAD), which mediates both pVHL-dependent degradation at normoxia and transcriptional activation at hypoxia.	Proline	42-45	hypoxia inducible factor 1, alpha subunit	Mus musculus	60-70
12468553-4	2003	One of the two critical proline residues, Pro(563) in mouse HIF-1alpha, is located within a bifunctional domain, the N-terminal transactivation domain (N-TAD), which mediates both pVHL-dependent degradation at normoxia and transcriptional activation at hypoxia.	Proline	42-45	von Hippel-Lindau tumor suppressor	Mus musculus	180-184
12468553-5	2003	Here we have identified two N-TAD residues, Tyr(564) and Ile(565), which, in addition to Pro(563), were critical for pVHL-mediated degradation at normoxia.	Proline	89-92	von Hippel-Lindau tumor suppressor	Mus musculus	117-121
12473651-4	2003	In this study, we further showed that the proline-rich domain of DOC-2/DAB2 could also interact with proteins containing the Src homology 3 domain, such as Src and Fgr.	Proline	42-49	DAB adaptor protein 2	Homo sapiens	65-70
12501243-8	2003	Using deletion mutants of 3BP2, two 14-3-3 binding domains were mapped to two proline-rich (residues 201-240 and 270-310) domains of 3BP2.	Proline	78-85	SH3-domain binding protein 2	Mus musculus	26-30
12501243-8	2003	Using deletion mutants of 3BP2, two 14-3-3 binding domains were mapped to two proline-rich (residues 201-240 and 270-310) domains of 3BP2.	Proline	78-85	SH3-domain binding protein 2	Mus musculus	133-137
12473651-4	2003	In this study, we further showed that the proline-rich domain of DOC-2/DAB2 could also interact with proteins containing the Src homology 3 domain, such as Src and Fgr.	Proline	42-49	DAB adaptor protein 2	Homo sapiens	71-75
12473651-4	2003	In this study, we further showed that the proline-rich domain of DOC-2/DAB2 could also interact with proteins containing the Src homology 3 domain, such as Src and Fgr.	Proline	42-49	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	125-128
12473651-4	2003	In this study, we further showed that the proline-rich domain of DOC-2/DAB2 could also interact with proteins containing the Src homology 3 domain, such as Src and Fgr.	Proline	42-49	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	156-159
12473651-4	2003	In this study, we further showed that the proline-rich domain of DOC-2/DAB2 could also interact with proteins containing the Src homology 3 domain, such as Src and Fgr.	Proline	42-49	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	164-167
12464621-11	2003	Since this association involves the proline-rich sequences of Gab2, it probably involves the Src homology 3 domain of Src kinase.	Proline	36-43	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	118-121
12464621-12	2003	Mutation of the proline-rich sequences in Gab2 prevented EGF-induced Gab2 phosphorylation, PI3-kinase/Akt activation, and DNA synthesis, demonstrating that Gab2 phosphorylation is critical for EGF-induced mitogenesis and is not complemented by ErbB3 or Shc phosphorylation.	Proline	16-23	GRB2-associated binding protein 2	Rattus norvegicus	42-46
12464621-11	2003	Since this association involves the proline-rich sequences of Gab2, it probably involves the Src homology 3 domain of Src kinase.	Proline	36-43	GRB2-associated binding protein 2	Rattus norvegicus	62-66
12464621-11	2003	Since this association involves the proline-rich sequences of Gab2, it probably involves the Src homology 3 domain of Src kinase.	Proline	36-43	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	93-96
12477732-4	2003	In the present study, we show that the Src homology 3 (SH3) domain of EA associates with the proline-rich domain of N-WASP and dynamin in vitro.	Proline	93-100	WASP like actin nucleation promoting factor	Homo sapiens	116-122
12477732-9	2003	These results suggest that, upon EGF stimulation, N-WASP interacts with EA through its proline-rich domain to induce the fission step of clathrin-mediated endocytosis.	Proline	87-94	epidermal growth factor	Homo sapiens	33-36
12464621-12	2003	Mutation of the proline-rich sequences in Gab2 prevented EGF-induced Gab2 phosphorylation, PI3-kinase/Akt activation, and DNA synthesis, demonstrating that Gab2 phosphorylation is critical for EGF-induced mitogenesis and is not complemented by ErbB3 or Shc phosphorylation.	Proline	16-23	epidermal growth factor like 1	Rattus norvegicus	57-60
12477732-9	2003	These results suggest that, upon EGF stimulation, N-WASP interacts with EA through its proline-rich domain to induce the fission step of clathrin-mediated endocytosis.	Proline	87-94	WASP like actin nucleation promoting factor	Homo sapiens	50-56
12464621-12	2003	Mutation of the proline-rich sequences in Gab2 prevented EGF-induced Gab2 phosphorylation, PI3-kinase/Akt activation, and DNA synthesis, demonstrating that Gab2 phosphorylation is critical for EGF-induced mitogenesis and is not complemented by ErbB3 or Shc phosphorylation.	Proline	16-23	GRB2-associated binding protein 2	Rattus norvegicus	69-73
12464621-12	2003	Mutation of the proline-rich sequences in Gab2 prevented EGF-induced Gab2 phosphorylation, PI3-kinase/Akt activation, and DNA synthesis, demonstrating that Gab2 phosphorylation is critical for EGF-induced mitogenesis and is not complemented by ErbB3 or Shc phosphorylation.	Proline	16-23	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
12464621-12	2003	Mutation of the proline-rich sequences in Gab2 prevented EGF-induced Gab2 phosphorylation, PI3-kinase/Akt activation, and DNA synthesis, demonstrating that Gab2 phosphorylation is critical for EGF-induced mitogenesis and is not complemented by ErbB3 or Shc phosphorylation.	Proline	16-23	GRB2-associated binding protein 2	Rattus norvegicus	69-73
12464621-12	2003	Mutation of the proline-rich sequences in Gab2 prevented EGF-induced Gab2 phosphorylation, PI3-kinase/Akt activation, and DNA synthesis, demonstrating that Gab2 phosphorylation is critical for EGF-induced mitogenesis and is not complemented by ErbB3 or Shc phosphorylation.	Proline	16-23	epidermal growth factor like 1	Rattus norvegicus	193-196
12464621-12	2003	Mutation of the proline-rich sequences in Gab2 prevented EGF-induced Gab2 phosphorylation, PI3-kinase/Akt activation, and DNA synthesis, demonstrating that Gab2 phosphorylation is critical for EGF-induced mitogenesis and is not complemented by ErbB3 or Shc phosphorylation.	Proline	16-23	erb-b2 receptor tyrosine kinase 3	Rattus norvegicus	244-249
12488320-0	2003	The proline-rich domain of dynamin-2 is responsible for dynamin-dependent in vitro potentiation of endothelial nitric-oxide synthase activity via selective effects on reductase domain function.	Proline	4-11	dynamin 2	Homo sapiens	27-36
12488320-0	2003	The proline-rich domain of dynamin-2 is responsible for dynamin-dependent in vitro potentiation of endothelial nitric-oxide synthase activity via selective effects on reductase domain function.	Proline	4-11	nitric oxide synthase 3	Homo sapiens	99-132
12488320-4	2003	Here we demonstrate, using purified proteins, that this occurs through a selective influence of the dyn-2 proline-rich domain (dyn-2 PRD) on the eNOS reductase domain.	Proline	106-113	dynamin 2	Homo sapiens	100-105
12488320-4	2003	Here we demonstrate, using purified proteins, that this occurs through a selective influence of the dyn-2 proline-rich domain (dyn-2 PRD) on the eNOS reductase domain.	Proline	106-113	dynamin 2	Homo sapiens	127-132
12574510-1	2003	The gene EPXH2 encodes for the soluble epoxide hydrolase (sEH), an enzyme involved in the regulation of cardiovascular and renal physiology containing two distinct domains connected via a proline-rich linker.	Proline	188-195	epoxide hydrolase 2	Homo sapiens	31-56
12393546-2	2003	The tumor suppressor von Hippel-Lindau (VHL) participates in the hypoxia-sensing pathway, as it binds to the proline-hydroxylated form of the hypoxia-inducible factor 1alpha (HIF-1alpha) and mediates its ubiquitination and proteosomal degradation.	Proline	109-116	von Hippel-Lindau tumor suppressor	Homo sapiens	40-43
12393546-2	2003	The tumor suppressor von Hippel-Lindau (VHL) participates in the hypoxia-sensing pathway, as it binds to the proline-hydroxylated form of the hypoxia-inducible factor 1alpha (HIF-1alpha) and mediates its ubiquitination and proteosomal degradation.	Proline	109-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-173
12393546-2	2003	The tumor suppressor von Hippel-Lindau (VHL) participates in the hypoxia-sensing pathway, as it binds to the proline-hydroxylated form of the hypoxia-inducible factor 1alpha (HIF-1alpha) and mediates its ubiquitination and proteosomal degradation.	Proline	109-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	175-185
12574510-1	2003	The gene EPXH2 encodes for the soluble epoxide hydrolase (sEH), an enzyme involved in the regulation of cardiovascular and renal physiology containing two distinct domains connected via a proline-rich linker.	Proline	188-195	epoxide hydrolase 2	Homo sapiens	58-61
12460991-1	2003	Integrin beta(3) is polymorphic at residue 33 (Leu(33) or Pro(33)), and the Pro(33) variant exhibits increased outside-in signaling to focal adhesion kinase and greater actin reorganization.	Proline	58-61	integrin subunit beta 3	Homo sapiens	0-16
12466283-10	2003	In contrast, LD78beta, a natural MIP-1alpha variant, which, like RANTES, contains a proline at position 2, activated these mutants as well as RANTES.	Proline	84-91	C-C motif chemokine ligand 3 like 3	Homo sapiens	13-21
12466283-10	2003	In contrast, LD78beta, a natural MIP-1alpha variant, which, like RANTES, contains a proline at position 2, activated these mutants as well as RANTES.	Proline	84-91	C-C motif chemokine ligand 3	Homo sapiens	33-43
12466283-10	2003	In contrast, LD78beta, a natural MIP-1alpha variant, which, like RANTES, contains a proline at position 2, activated these mutants as well as RANTES.	Proline	84-91	C-C motif chemokine ligand 5	Homo sapiens	65-71
12594038-5	2003	Like its vertebrate counterparts, Zyx102 displays three carboxy-terminal LIM domains, a potential nuclear export signal, and three proline-rich motifs, one of which matches the consensus for mediating an interaction with Ena/VASP (Drosophila Enabled/Vasodilator-stimulated phosphoprotein) proteins.	Proline	131-138	Zyxin	Drosophila melanogaster	34-40
12446682-3	2003	To investigate the significance of the isoleucine-proline (residues 2427-2428) dipeptide epitope, which is thought to form an essential part of the FKBP12.6 binding site in RyR2, we generated single and double mutants, P2428Q, I2427E/P2428A, and P2428A/L2429E, expressed them in HEK293 cells, and assessed their ability to bind GST-FKBP12.6.	Proline	50-57	FKBP prolyl isomerase 1B	Homo sapiens	148-156
12446682-3	2003	To investigate the significance of the isoleucine-proline (residues 2427-2428) dipeptide epitope, which is thought to form an essential part of the FKBP12.6 binding site in RyR2, we generated single and double mutants, P2428Q, I2427E/P2428A, and P2428A/L2429E, expressed them in HEK293 cells, and assessed their ability to bind GST-FKBP12.6.	Proline	50-57	ryanodine receptor 2	Homo sapiens	173-177
12529254-5	2003	Other results suggest that rP2X(7)-R-mediated ERK1/2 phosphorylation was linked to the phosphorylation of the proline-rich/Ca(2+)-activated tyrosine kinase Pyk2, c-Src, phosphatidylinositol 3"-kinase, and protein kinase Cdelta activities and was dependent on the presence of extracellular Ca(2+).	Proline	110-117	mitogen-activated protein kinase 3	Homo sapiens	46-52
12554669-3	2003	Surprisingly, we found that a trans cription factor, the proline-rich homeodomain protein PRH, is a negative regulator of eIF4E in myeloid cells, interacting with eIF4E through a conserved binding site typically found in translational regulators.	Proline	57-64	hematopoietically expressed homeobox	Homo sapiens	90-93
12554669-3	2003	Surprisingly, we found that a trans cription factor, the proline-rich homeodomain protein PRH, is a negative regulator of eIF4E in myeloid cells, interacting with eIF4E through a conserved binding site typically found in translational regulators.	Proline	57-64	eukaryotic translation initiation factor 4E	Homo sapiens	122-127
12554669-3	2003	Surprisingly, we found that a trans cription factor, the proline-rich homeodomain protein PRH, is a negative regulator of eIF4E in myeloid cells, interacting with eIF4E through a conserved binding site typically found in translational regulators.	Proline	57-64	eukaryotic translation initiation factor 4E	Homo sapiens	163-168
12388190-2	2003	In the present study, the role of a highly conserved Trp residue at position 1242 on MRP3 transport function was examined by expressing wild-type MRP3 and Ala-, Cys-, Phe-, Tyr-, and Pro-substituted mutants in human embryonic kidney 293T cells.	Proline	183-186	ATP binding cassette subfamily B member 4	Homo sapiens	85-89
12529254-5	2003	Other results suggest that rP2X(7)-R-mediated ERK1/2 phosphorylation was linked to the phosphorylation of the proline-rich/Ca(2+)-activated tyrosine kinase Pyk2, c-Src, phosphatidylinositol 3"-kinase, and protein kinase Cdelta activities and was dependent on the presence of extracellular Ca(2+).	Proline	110-117	protein tyrosine kinase 2 beta	Homo sapiens	156-160
12655141-5	2003	Patient CS2SE was a compound heterozygote for this deletion and an amino acid substitution at the 106th glutamine to proline (Q106P) in the WD-40 repeat motif of the CSA protein, which resulted in a defective nucleotide excision repair.	Proline	117-124	chorionic somatomammotropin hormone 1	Homo sapiens	166-169
12529254-5	2003	Other results suggest that rP2X(7)-R-mediated ERK1/2 phosphorylation was linked to the phosphorylation of the proline-rich/Ca(2+)-activated tyrosine kinase Pyk2, c-Src, phosphatidylinositol 3"-kinase, and protein kinase Cdelta activities and was dependent on the presence of extracellular Ca(2+).	Proline	110-117	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	162-167
12568815-5	2003	When comparing with human Hb alpha-chain, alterations in important regions can be noted: alpha110 Ala-Gly, alpha114 Pro-Gly, alpha117 Phe-Tyr and alpha122 His-Gln.	Proline	116-119	Fc gamma receptor and transporter	Homo sapiens	29-40
12508107-4	2003	The binding site of MegBP was mapped to an N-terminal region on the receptor tail harboring a proline-rich peptide element.	Proline	94-101	LRP2 binding protein	Homo sapiens	20-25
12614350-6	2003	One of the hallmarks of these early changes in TCR conformation is the induced recruitment of the adapter protein Nck to a proline-rich sequence of the cytoplasmic tail of CD3epsilon, but there may be others.	Proline	123-130	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	47-50
12614350-6	2003	One of the hallmarks of these early changes in TCR conformation is the induced recruitment of the adapter protein Nck to a proline-rich sequence of the cytoplasmic tail of CD3epsilon, but there may be others.	Proline	123-130	NCK adaptor protein 1	Homo sapiens	114-117
12614350-6	2003	One of the hallmarks of these early changes in TCR conformation is the induced recruitment of the adapter protein Nck to a proline-rich sequence of the cytoplasmic tail of CD3epsilon, but there may be others.	Proline	123-130	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	172-182
12760422-3	2003	Both residues are phosphorylated to about the same extent and are in the highly conserved segment Asn91-Ile-Val-Thr94-Pro-Arg-Thr97-Pro-Pro-Pro-Ser101 MALDI mass spectrometry before and after ERK2 treatment revealed the addition of two phosphate groups to the protein.	Proline	118-121	mitogen-activated protein kinase 1	Bos taurus	192-196
12560569-0	2003	The proline-rich region of the ecotropic Moloney murine leukaemia virus envelope protein tolerates the insertion of the green fluorescent protein and allows the generation of replication-competent virus.	Proline	4-11	melanoma antigen	Mus musculus	72-88
12560569-2	2003	Insertion of these sequences into the proline-rich region (PRR) of Env resulted in a chimeric GFP-Env protein that allowed retrovirus vector transduction of murine cells with titres similar to wild-type Env.	Proline	38-45	melanoma antigen	Mus musculus	67-70
12560569-2	2003	Insertion of these sequences into the proline-rich region (PRR) of Env resulted in a chimeric GFP-Env protein that allowed retrovirus vector transduction of murine cells with titres similar to wild-type Env.	Proline	38-45	melanoma antigen	Mus musculus	98-101
12560569-2	2003	Insertion of these sequences into the proline-rich region (PRR) of Env resulted in a chimeric GFP-Env protein that allowed retrovirus vector transduction of murine cells with titres similar to wild-type Env.	Proline	38-45	melanoma antigen	Mus musculus	98-101
12615363-4	2003	RESULTS: We identified a 420-amino acid-long protein containing a proline-rich stretch and five carboxyl-terminal SH3 domains, which we have termed Sh3d19.	Proline	66-73	SH3 domain protein D19	Mus musculus	148-154
12760422-3	2003	Both residues are phosphorylated to about the same extent and are in the highly conserved segment Asn91-Ile-Val-Thr94-Pro-Arg-Thr97-Pro-Pro-Pro-Ser101 MALDI mass spectrometry before and after ERK2 treatment revealed the addition of two phosphate groups to the protein.	Proline	132-135	mitogen-activated protein kinase 1	Bos taurus	192-196
12760422-3	2003	Both residues are phosphorylated to about the same extent and are in the highly conserved segment Asn91-Ile-Val-Thr94-Pro-Arg-Thr97-Pro-Pro-Pro-Ser101 MALDI mass spectrometry before and after ERK2 treatment revealed the addition of two phosphate groups to the protein.	Proline	132-135	mitogen-activated protein kinase 1	Bos taurus	192-196
12760422-3	2003	Both residues are phosphorylated to about the same extent and are in the highly conserved segment Asn91-Ile-Val-Thr94-Pro-Arg-Thr97-Pro-Pro-Pro-Ser101 MALDI mass spectrometry before and after ERK2 treatment revealed the addition of two phosphate groups to the protein.	Proline	132-135	mitogen-activated protein kinase 1	Bos taurus	192-196
12620234-3	2003	The SLP-76 peptide engages four distinct binding pockets on the surface of the Gads SH3 domain and upon binding adopts a unique structure characterized by a right-handed 3(10) helix at the RSTK locus, in contrast to the left-handed polyproline type II helix formed by canonical proline-rich SH3 ligands.	Proline	236-243	lymphocyte cytosolic protein 2	Homo sapiens	4-10
12417582-1	2003	The collagen prolyl 4-hydroxylase (P4H) class of enzymes catalyze the hydroxylation of prolines in the X-Pro-Gly repeats of collagen chains.	Proline	87-95	Uncharacterized protein	Brugia malayi	13-33
12602867-11	2003	Regulation of P5CS1 expression thus appears to play a principal role in controlling proline accumulation stimulated by ABA and salt stress in Arabidopsis.	Proline	84-91	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	14-19
12602867-3	2003	Stimulation of proline synthesis by abscisic acid (ABA) and salt stress correlates with a striking activation of P5CS1 expression.	Proline	15-22	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	113-118
12602867-9	2003	Proline accumulation and induction of P5CS1 transcription are simultaneously enhanced in the ABA-hypersensitive prl1 and brassinosteroid-deficient det2 mutants, whereas P5CS2 shows enhanced induction by ABA and salt only in the det2 mutant.	Proline	0-7	pleiotropic regulatory locus 1	Arabidopsis thaliana	112-116
12602867-9	2003	Proline accumulation and induction of P5CS1 transcription are simultaneously enhanced in the ABA-hypersensitive prl1 and brassinosteroid-deficient det2 mutants, whereas P5CS2 shows enhanced induction by ABA and salt only in the det2 mutant.	Proline	0-7	3-oxo-5-alpha-steroid 4-dehydrogenase family protein	Arabidopsis thaliana	147-151
12417582-1	2003	The collagen prolyl 4-hydroxylase (P4H) class of enzymes catalyze the hydroxylation of prolines in the X-Pro-Gly repeats of collagen chains.	Proline	87-95	Uncharacterized protein	Brugia malayi	35-38
12441356-5	2003	We found that the LIM domains are the main focal adhesion targeting elements and that the proline-rich region of LPP, which harbors binding sites for alpha-actinin and vasodilator-stimulated phosphoprotein (VASP), has a weak targeting capacity.	Proline	90-97	LIM domain containing preferred translocation partner in lipoma	Homo sapiens	113-116
12441356-5	2003	We found that the LIM domains are the main focal adhesion targeting elements and that the proline-rich region of LPP, which harbors binding sites for alpha-actinin and vasodilator-stimulated phosphoprotein (VASP), has a weak targeting capacity.	Proline	90-97	actinin alpha 1	Homo sapiens	150-163
12517958-5	2003	We also report that, in addition to the previously characterized N- and C-terminal nuclear localization signal elements, there is an additional N-terminal nuclear localization activity, present between aa 209 and 222, which overlaps the proline/serine/threonine-rich domain of CIITA.	Proline	237-244	class II major histocompatibility complex transactivator	Homo sapiens	277-282
12441356-5	2003	We found that the LIM domains are the main focal adhesion targeting elements and that the proline-rich region of LPP, which harbors binding sites for alpha-actinin and vasodilator-stimulated phosphoprotein (VASP), has a weak targeting capacity.	Proline	90-97	vasodilator stimulated phosphoprotein	Homo sapiens	168-205
12441356-5	2003	We found that the LIM domains are the main focal adhesion targeting elements and that the proline-rich region of LPP, which harbors binding sites for alpha-actinin and vasodilator-stimulated phosphoprotein (VASP), has a weak targeting capacity.	Proline	90-97	vasodilator stimulated phosphoprotein	Homo sapiens	207-211
12441356-8	2003	The proline-rich region of LPP contains targeting sites for focal adhesions and stress fibers that are distinct from the alpha-actinin and VASP binding sites, and the LPP LIM domains are dispensable for targeting LPP to the nucleus.	Proline	4-11	LIM domain containing preferred translocation partner in lipoma	Homo sapiens	27-30
12525176-7	2003	The proline-rich FH1 domain binds profilin, and deletion of this domain decreases the contribution of profilin-actin to the nucleation.	Proline	4-11	profilin	Saccharomyces cerevisiae S288C	34-42
12525176-7	2003	The proline-rich FH1 domain binds profilin, and deletion of this domain decreases the contribution of profilin-actin to the nucleation.	Proline	4-11	profilin	Saccharomyces cerevisiae S288C	102-110
12553912-3	2003	A 2.7 A X-ray crystal structure of a Skp1-Cdc4 complex bound to a high-affinity CPD phosphopeptide from human cyclin E reveals a core CPD motif, Leu-Leu-pThr-Pro, bound to an eight-bladed WD40 propeller domain in Cdc4.	Proline	158-161	S-phase kinase associated protein 1	Homo sapiens	37-41
12553912-3	2003	A 2.7 A X-ray crystal structure of a Skp1-Cdc4 complex bound to a high-affinity CPD phosphopeptide from human cyclin E reveals a core CPD motif, Leu-Leu-pThr-Pro, bound to an eight-bladed WD40 propeller domain in Cdc4.	Proline	158-161	F-box and WD repeat domain containing 7	Homo sapiens	42-46
12482424-0	2003	Identification of TNF-alpha inhibitors from a split-pool library based on a tyrosine-proline peptidomimetic scaffold.	Proline	85-92	tumor necrosis factor	Homo sapiens	18-27
12527723-6	2003	hPAT1 interacted with glycine, L-alanine, L-proline, alpha-aminoisobutyrate (AIB) and gamma-aminobutyrate (GABA), as evidenced from direct transport measurements and from competition experiments with MeAIB as a transport substrate.	Proline	42-51	solute carrier family 36 member 1	Homo sapiens	0-5
12527723-7	2003	hPAT1 also recognized the D-isomers of alanine and proline.	Proline	51-58	solute carrier family 36 member 1	Homo sapiens	0-5
12489124-4	2003	Enzyme activity doubled upon nitrogen starvation of either ammonium-grown (possibly due to Nil2p/Deh1p derepression) or proline-grown (due to Dal80p derepression) cells.	Proline	120-127	Dal80p	Saccharomyces cerevisiae S288C	142-148
12489124-5	2003	The ure2 mutation increased enzyme levels five-fold in fresh ammonium-grown cells and ten-fold in fresh proline-grown cells.	Proline	104-111	glutathione peroxidase	Saccharomyces cerevisiae S288C	4-8
12489124-6	2003	The combined effects of the ure2 mutation and nitrogen starvation on ammonium- or proline-grown cells resulted in an overall 10-20-fold enzyme activity increase, respectively, in comparison with the wild-type cells.	Proline	82-89	glutathione peroxidase	Saccharomyces cerevisiae S288C	28-32
12504111-2	2003	Using yeast two-hybrid, GST-pulldown, and coimmunoprecipitation studies, we isolated the CAP cDNA as a specific partner of SHIP2 proline-rich domain and showed by GST-pulldown experiments that the interaction took place with the SH3C of CAP.	Proline	129-136	inositol polyphosphate phosphatase-like 1	Mus musculus	123-128
12513997-0	2003	L-proline accumulation and freeze tolerance of Saccharomyces cerevisiae are caused by a mutation in the PRO1 gene encoding gamma-glutamyl kinase.	Proline	0-9	glutamate 5-kinase	Saccharomyces cerevisiae S288C	104-108
12833172-1	2003	Studies on type I procollagen produced by skin fibroblasts cultured from twins with lethal type II of osteogenesis imperfecta (OI) showed that biosynthesis of collagen (measured by L-[5-(3)H]proline incorporation into proteins susceptible to the action of bacterial collagenase) was slightly increased as compared to the control healthy infant.	Proline	191-198	collagen type I alpha 2 chain	Homo sapiens	11-29
12513997-4	2003	Interestingly, the allele of PRO1 was shown to enhance the activities of gamma-glutamyl kinase and gamma-glutamyl phosphate reductase, both of which catalyze the first two steps of L-proline synthesis from L-glutamate and which together may form a complex in vivo.	Proline	181-190	glutamate 5-kinase	Saccharomyces cerevisiae S288C	29-33
12513997-3	2003	By introducing the mutant-derived genomic library into a non-L-proline-utilizing strain, the mutant was found to carry an allele of the wild-type PRO1 gene encoding gamma-glutamyl kinase, which resulted in a single amino acid replacement; Asp (GAC) at position 154 was replaced by Asn (AAC).	Proline	61-70	glutamate 5-kinase	Saccharomyces cerevisiae S288C	146-150
12897450-1	2003	The mitogen-activated protein (MAP) kinases are a large family of proline-directed, serine/threonine kinases that require tyrosine and threonine phosphorylation of a TxY motif in the activation loop for activation through a phosphorylation cascade involving a MAPKKK, MAPKK and MAPK, often referred to as the MAP kinase module.	Proline	66-73	mitogen-activated protein kinase kinase kinase 4	Homo sapiens	260-266
12534323-1	2003	Adis CommentsPramlintide [AC 0137, AC 137, tripro-amylin, Symlin] is a synthetic human amylin analogue with proline substitutions at positions 25, 28 and 29, which limits the self-aggregation seen with native amylin.	Proline	108-115	islet amyloid polypeptide	Homo sapiens	50-56
12534323-1	2003	Adis CommentsPramlintide [AC 0137, AC 137, tripro-amylin, Symlin] is a synthetic human amylin analogue with proline substitutions at positions 25, 28 and 29, which limits the self-aggregation seen with native amylin.	Proline	108-115	islet amyloid polypeptide	Homo sapiens	87-93
12534323-1	2003	Adis CommentsPramlintide [AC 0137, AC 137, tripro-amylin, Symlin] is a synthetic human amylin analogue with proline substitutions at positions 25, 28 and 29, which limits the self-aggregation seen with native amylin.	Proline	108-115	islet amyloid polypeptide	Homo sapiens	87-93
14513722-2	2003	(1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform.	Proline	22-29	tumor protein p53	Homo sapiens	95-98
12631385-1	2003	The prolyl isomerase Pin1 specifically isomerizes certain phosphorylated Ser/Thr-Pro bonds and thereby regulates various cellular processes.	Proline	81-84	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	21-25
14513722-2	2003	(1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform.	Proline	22-29	tumor protein p53	Homo sapiens	172-175
14513722-2	2003	(1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform.	Proline	22-29	tumor protein p53	Homo sapiens	172-175
14513722-2	2003	(1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform.	Proline	299-306	tumor protein p53	Homo sapiens	95-98
14513722-2	2003	(1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform.	Proline	299-306	tumor protein p53	Homo sapiens	172-175
14513722-2	2003	(1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform.	Proline	299-306	tumor protein p53	Homo sapiens	172-175
12393698-2	2003	This mutation, which was present in the proband and his father, predicts the substitution of Cys for Arg at position 760 of pre-pro-VWF, 4 residues before the propeptide cleavage site belonging to a consensus sequence for substrate recognition by the processing enzyme paired dibasic amino acid-cleaving enzyme (PACE)/furin.	Proline	40-43	von Willebrand factor	Homo sapiens	132-135
12393698-2	2003	This mutation, which was present in the proband and his father, predicts the substitution of Cys for Arg at position 760 of pre-pro-VWF, 4 residues before the propeptide cleavage site belonging to a consensus sequence for substrate recognition by the processing enzyme paired dibasic amino acid-cleaving enzyme (PACE)/furin.	Proline	40-43	furin, paired basic amino acid cleaving enzyme	Homo sapiens	312-316
12393698-2	2003	This mutation, which was present in the proband and his father, predicts the substitution of Cys for Arg at position 760 of pre-pro-VWF, 4 residues before the propeptide cleavage site belonging to a consensus sequence for substrate recognition by the processing enzyme paired dibasic amino acid-cleaving enzyme (PACE)/furin.	Proline	40-43	furin, paired basic amino acid cleaving enzyme	Homo sapiens	318-323
12451594-6	2003	Efficient elongation was found to require zyxin, VASP, and profilin, proteins that interact by means of their ABM-1 and ABM-2 proline-rich motifs.	Proline	126-133	vasodilator stimulated phosphoprotein	Homo sapiens	49-53
12530983-2	2003	Here, we show that antigen-induced formation of T cell:APC conjugates and synapses is abrogated in WASp-deficient T cells and that CD2 engagement evokes interactions between the proline-rich region required for WASp translocation to the synapse and the PSTPIP1 adaptor SH3 domain and between the PSTPIp1 coiled-coil domain and both CD2 and another CD2-binding adaptor, CD2AP.	Proline	178-185	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	296-303
12535629-9	2003	The cloned enzyme, like the native species, is relatively insensitive to inhibition by PTU, but mutation of Ser-159 in FhD1 to the Pro residue found in D2 and D3 isoforms increased the sensitivity to PTU.	Proline	131-134	type I iodothyronine deiodinase	Fundulus heteroclitus	119-123
12535629-9	2003	The cloned enzyme, like the native species, is relatively insensitive to inhibition by PTU, but mutation of Ser-159 in FhD1 to the Pro residue found in D2 and D3 isoforms increased the sensitivity to PTU.	Proline	131-134	type II iodothyronine deiodinase	Fundulus heteroclitus	152-161
12530983-2	2003	Here, we show that antigen-induced formation of T cell:APC conjugates and synapses is abrogated in WASp-deficient T cells and that CD2 engagement evokes interactions between the proline-rich region required for WASp translocation to the synapse and the PSTPIP1 adaptor SH3 domain and between the PSTPIp1 coiled-coil domain and both CD2 and another CD2-binding adaptor, CD2AP.	Proline	178-185	CD2 molecule	Homo sapiens	332-335
12708345-1	2003	In codon 72 of the p53 antioncogene there are two alleles, arginine and proline; the arg/arg genotype has recently been identified as a risk factor for developing of cervicouterine cancer (CuCa) associated to human papillomavirus (HVP) infection.	Proline	72-79	tumor protein p53	Homo sapiens	19-22
12708345-5	2003	From 102 analyzed samples, p53-arginine allele corresponded to 67.64% and p53-proline allele corresponded to 32.36%; 47 women (46.10%) were arg/arg homocygotes, 11 women (10.77%) were pro/pro homocygotes, 44 women (43.13%) were arg/pro heterocigotes; the genotype distribution was within the Hardy-Weinberg equilibrium.	Proline	78-85	tumor protein p53	Homo sapiens	74-77
12530983-2	2003	Here, we show that antigen-induced formation of T cell:APC conjugates and synapses is abrogated in WASp-deficient T cells and that CD2 engagement evokes interactions between the proline-rich region required for WASp translocation to the synapse and the PSTPIP1 adaptor SH3 domain and between the PSTPIp1 coiled-coil domain and both CD2 and another CD2-binding adaptor, CD2AP.	Proline	178-185	CD2 molecule	Homo sapiens	131-134
12530983-2	2003	Here, we show that antigen-induced formation of T cell:APC conjugates and synapses is abrogated in WASp-deficient T cells and that CD2 engagement evokes interactions between the proline-rich region required for WASp translocation to the synapse and the PSTPIP1 adaptor SH3 domain and between the PSTPIp1 coiled-coil domain and both CD2 and another CD2-binding adaptor, CD2AP.	Proline	178-185	WASP actin nucleation promoting factor	Homo sapiens	99-103
12530983-2	2003	Here, we show that antigen-induced formation of T cell:APC conjugates and synapses is abrogated in WASp-deficient T cells and that CD2 engagement evokes interactions between the proline-rich region required for WASp translocation to the synapse and the PSTPIP1 adaptor SH3 domain and between the PSTPIp1 coiled-coil domain and both CD2 and another CD2-binding adaptor, CD2AP.	Proline	178-185	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	253-260
12530983-2	2003	Here, we show that antigen-induced formation of T cell:APC conjugates and synapses is abrogated in WASp-deficient T cells and that CD2 engagement evokes interactions between the proline-rich region required for WASp translocation to the synapse and the PSTPIP1 adaptor SH3 domain and between the PSTPIp1 coiled-coil domain and both CD2 and another CD2-binding adaptor, CD2AP.	Proline	178-185	CD2 molecule	Homo sapiens	332-335
12530983-2	2003	Here, we show that antigen-induced formation of T cell:APC conjugates and synapses is abrogated in WASp-deficient T cells and that CD2 engagement evokes interactions between the proline-rich region required for WASp translocation to the synapse and the PSTPIP1 adaptor SH3 domain and between the PSTPIp1 coiled-coil domain and both CD2 and another CD2-binding adaptor, CD2AP.	Proline	178-185	CD2 associated protein	Homo sapiens	369-374
12511593-3	2003	In ABCA1, we identified a sequence rich in proline, glutamic acid, serine, and threonine (PEST sequence) that enhances the degradation of ABCA1 by calpain protease and thereby controls the cell surface concentration and cholesterol efflux activity of ABCA1.	Proline	43-50	ATP binding cassette subfamily A member 1	Homo sapiens	3-8
12511593-3	2003	In ABCA1, we identified a sequence rich in proline, glutamic acid, serine, and threonine (PEST sequence) that enhances the degradation of ABCA1 by calpain protease and thereby controls the cell surface concentration and cholesterol efflux activity of ABCA1.	Proline	43-50	ATP binding cassette subfamily A member 1	Homo sapiens	138-143
12511593-3	2003	In ABCA1, we identified a sequence rich in proline, glutamic acid, serine, and threonine (PEST sequence) that enhances the degradation of ABCA1 by calpain protease and thereby controls the cell surface concentration and cholesterol efflux activity of ABCA1.	Proline	43-50	ATP binding cassette subfamily A member 1	Homo sapiens	138-143
12532266-5	2003	Usp15 can also cleave the ubiquitin-proline bond, as can USP15 and Usp4.	Proline	36-43	ubiquitin specific peptidase 15	Mus musculus	0-5
12635827-4	2003	The genotype of p53 codon 72 (Arg/Arg, Arg/Pro, or Pro/Pro) was determined for all subjects by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP).	Proline	43-46	tumor protein p53	Homo sapiens	16-19
12591234-3	2003	MATERIALS AND METHODS: The effect of TGF-beta on type I collagen biosynthesis was determined by a [3H]proline incorporation assay and Northern blotting.	Proline	102-109	transforming growth factor beta 1	Homo sapiens	37-45
12558988-6	2003	The novel interaction with the amphiphysin SH3 domain, involving the COOH-terminal proline-rich region of FAK, was confirmed by coimmunoprecipitation of the two proteins and a closely similar response to stimuli affecting the actin cytoskeleton.	Proline	83-90	protein tyrosine kinase 2	Homo sapiens	106-109
12532266-5	2003	Usp15 can also cleave the ubiquitin-proline bond, as can USP15 and Usp4.	Proline	36-43	ubiquitin specific peptidase 15	Mus musculus	57-62
12532266-5	2003	Usp15 can also cleave the ubiquitin-proline bond, as can USP15 and Usp4.	Proline	36-43	ubiquitin specific peptidase 4 (proto-oncogene)	Mus musculus	67-71
12732238-4	2003	The soluble RGD-containing peptide glycine-arginine-glycine-aspartate-serine-proline (GRGDSP) increased neurotrophin mRNA levels in transcript- and subfield-specific fashions.	Proline	77-84	brain derived neurotrophic factor	Homo sapiens	104-116
12765336-6	2003	In addition, CAP4 contains a proline-rich region, part of which exists in CAP3.	Proline	29-36	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	74-78
15526500-4	2003	The natural sequence in human insulin at this position is proline at B28 and lysine at B29.	Proline	58-65	insulin	Homo sapiens	30-37
12399475-4	2002	Grb2 and RN-tre associate both in vitro and in vivo, with interaction mediated by both SH3 domains of Grb2 and extended proline-rich sequences in RN-tre.	Proline	120-127	growth factor receptor bound protein 2	Homo sapiens	0-4
12778798-6	2003	It was found that the SNAP inhibited the [3H]-proline incorporation in cultured fibroblasts, but the rate of [3H]-proline incorporation induced by ET-1 was unaltered.	Proline	114-121	endothelin 1	Homo sapiens	147-151
12778798-4	2003	The values of [3H]-TdR absorption in the 2.5 ng/ml, 25 ng/ml and 100 ng/ml of ET-1 groups were 1.8 times, 4 times and 4.9 times more than in the control group, respectively (P &lt; 0.01), while the values of the [3H]-proline incorporation were 1.1 times, 3.1 times and 3.8 times respectively (P &lt; 0.01).	Proline	217-224	endothelin 1	Homo sapiens	78-82
12399475-4	2002	Grb2 and RN-tre associate both in vitro and in vivo, with interaction mediated by both SH3 domains of Grb2 and extended proline-rich sequences in RN-tre.	Proline	120-127	USP6 N-terminal like	Homo sapiens	9-15
12399475-4	2002	Grb2 and RN-tre associate both in vitro and in vivo, with interaction mediated by both SH3 domains of Grb2 and extended proline-rich sequences in RN-tre.	Proline	120-127	USP6 N-terminal like	Homo sapiens	146-152
12482578-2	2002	We have investigated the binding of nebulin SH3 with proline-rich peptides derived from the 28-mer PEVK modules of titin and the Z-line protein myopalladin, using fluorescence, circular dichroism and nuclear magnetic resonance techniques.	Proline	53-60	nebulin	Homo sapiens	36-43
12481032-6	2002	The results show that TTR(105-115) adopts an extended beta-strand conformation that is similar to that found in the native protein except for substantial differences in the vicinity of the proline residue.	Proline	189-196	transthyretin	Homo sapiens	22-25
12388550-1	2002	PAX6 functions as a transcription factor and has two DNA-binding domains, a paired domain (PD) and a homeodomain (HD), joined by a glycine-rich linker and followed by a proline-serine-threonine-rich (PST) transactivation region at the C terminus.	Proline	169-176	paired box 6	Homo sapiens	0-4
12486229-0	2002	Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity.	Proline	10-17	huntingtin	Homo sapiens	82-92
12482596-4	2002	Replacing Ile249 in the third intracellular loop (3rd ICL) of the AT2 with proline, corresponding amino acid in the AT1, in the mutant M6, resulted in slightly reduced affinity to [125I]Ang II (K(d)=0.259 nM), however, did not abolish the inhibition.	Proline	75-82	angiotensin II receptor, type 1a	Rattus norvegicus	116-119
12471135-3	2002	CD26/DPPIV has the ability to cleave the chemokine CXCL12/stromal cell-derived factor 1alpha (SDF-1alpha) at its position two proline.	Proline	126-133	dipeptidyl peptidase 4	Homo sapiens	0-4
12482596-4	2002	Replacing Ile249 in the third intracellular loop (3rd ICL) of the AT2 with proline, corresponding amino acid in the AT1, in the mutant M6, resulted in slightly reduced affinity to [125I]Ang II (K(d)=0.259 nM), however, did not abolish the inhibition.	Proline	75-82	angiotensinogen	Rattus norvegicus	186-192
12225289-5	2002	Activating transcription factor 3 (ATF3) is a basic leucine zipper protein which is highly homologous to c-Jun dimerization protein 2 (JDP2), especially within the threonine/proline phosphoacceptor site, Thr-148.	Proline	174-181	activating transcription factor 3	Homo sapiens	0-33
12225289-5	2002	Activating transcription factor 3 (ATF3) is a basic leucine zipper protein which is highly homologous to c-Jun dimerization protein 2 (JDP2), especially within the threonine/proline phosphoacceptor site, Thr-148.	Proline	174-181	activating transcription factor 3	Homo sapiens	35-39
12225289-5	2002	Activating transcription factor 3 (ATF3) is a basic leucine zipper protein which is highly homologous to c-Jun dimerization protein 2 (JDP2), especially within the threonine/proline phosphoacceptor site, Thr-148.	Proline	174-181	Jun dimerization protein 2	Homo sapiens	105-133
12225289-5	2002	Activating transcription factor 3 (ATF3) is a basic leucine zipper protein which is highly homologous to c-Jun dimerization protein 2 (JDP2), especially within the threonine/proline phosphoacceptor site, Thr-148.	Proline	174-181	Jun dimerization protein 2	Homo sapiens	135-139
12296770-4	2002	This gene, dgkA, encodes a deduced protein that contains three C1-type cysteine-rich repeats, a DGK catalytic domain most closely related to the theta subtype of mammalian DGKs and a C-terminal segment containing a proline/glutamine-rich region and a large aspargine-repeat region.	Proline	215-222	diacylglycerol kinase alpha	Homo sapiens	11-15
12406566-0	2002	Proline homozygosity in codon 72 of p53: a risk genotype for human papillomavirus related cervical cancer in Indian women.	Proline	0-7	tumor protein p53	Homo sapiens	36-39
12406566-7	2002	Thus, proline homozygosity at codon 72 of p53 and not arginine homozygosity, could be a risk factor for development of CaCx associated with high risk HPV among Indian women.	Proline	6-13	tumor protein p53	Homo sapiens	42-45
12471135-3	2002	CD26/DPPIV has the ability to cleave the chemokine CXCL12/stromal cell-derived factor 1alpha (SDF-1alpha) at its position two proline.	Proline	126-133	dipeptidyl peptidase 4	Homo sapiens	5-10
12471135-3	2002	CD26/DPPIV has the ability to cleave the chemokine CXCL12/stromal cell-derived factor 1alpha (SDF-1alpha) at its position two proline.	Proline	126-133	C-X-C motif chemokine ligand 12	Homo sapiens	51-57
12388558-2	2002	The increase in p53 stability depends critically on its phosphorylation on serine/threonine residues, including those preceding a proline (Ser(P)/Thr-Pro).	Proline	130-137	tumor protein p53	Homo sapiens	16-19
12351631-3	2002	Here we show that overexpression of PKA causes phosphorylation and cytoplasmic accumulation of NF-ATc1 in direct opposition to calcineurin by phosphorylating Ser-245, Ser-269, and Ser-294 in the conserved serine-proline repeat domain, and that mutation of these serines blocks the effect of PKA.	Proline	212-219	nuclear factor of activated T cells 1	Homo sapiens	95-102
12388558-3	2002	The Ser(P)/Thr-Pro moiety exists in the two distinct cis and trans conformations and their conversion is catalyzed specifically by the prolyl isomerase Pin1.	Proline	15-18	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	152-156
12459171-2	2002	In this report, we addressed the question whether the natural variability at p53 locus (the proline-arginine substitution at codon 72) affects the capacity of peripheral-blood mononuclear cells from healthy subjects to undergo in vitro apoptosis in response to the cytotoxic drug cytosine arabinoside.	Proline	92-99	tumor protein p53	Homo sapiens	77-80
12460579-2	2002	In the spliceosome, the Prp40 WW domains participate in cross-intron bridging by interacting with proline-rich regions present in the branch-point binding protein (BBP) and the U5 small nuclear ribonucleoprotein component Prp8.	Proline	98-105	Prp40p	Saccharomyces cerevisiae S288C	24-29
12359720-6	2002	Grg1-S has highest homology with the TLE family of large Groucho proteins but features only the amino-terminal Q and glycine- and proline-rich domains typical of the Groucho/AES subfamily.	Proline	130-137	TLE family member 1, transcriptional corepressor	Homo sapiens	0-4
12460579-2	2002	In the spliceosome, the Prp40 WW domains participate in cross-intron bridging by interacting with proline-rich regions present in the branch-point binding protein (BBP) and the U5 small nuclear ribonucleoprotein component Prp8.	Proline	98-105	U4/U6-U5 snRNP complex subunit PRP8	Saccharomyces cerevisiae S288C	222-226
12460579-9	2002	Moreover, the Prp40 WW domains are shown to bind proline-rich peptides devoid of aromatic residues, which are also recognised by the Abl-SH3 domain and the WW domain of the mammalian Prp40 orthologue formin binding protein 11.	Proline	49-56	pre-mRNA processing factor 40 homolog A	Homo sapiens	14-19
12460579-9	2002	Moreover, the Prp40 WW domains are shown to bind proline-rich peptides devoid of aromatic residues, which are also recognised by the Abl-SH3 domain and the WW domain of the mammalian Prp40 orthologue formin binding protein 11.	Proline	49-56	pre-mRNA processing factor 40 homolog A	Homo sapiens	183-188
12460579-9	2002	Moreover, the Prp40 WW domains are shown to bind proline-rich peptides devoid of aromatic residues, which are also recognised by the Abl-SH3 domain and the WW domain of the mammalian Prp40 orthologue formin binding protein 11.	Proline	49-56	pre-mRNA processing factor 40 homolog A	Homo sapiens	200-225
12485607-2	2002	The transactivation domain (TAD) of human AhR (hAhR) has potentially distinct acidic, glutamine-rich, and proline/serine/threonine-rich subdomains.	Proline	106-113	aryl hydrocarbon receptor	Homo sapiens	42-45
12500098-0	2002	A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans.	Proline	2-9	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	49-54
12485607-2	2002	The transactivation domain (TAD) of human AhR (hAhR) has potentially distinct acidic, glutamine-rich, and proline/serine/threonine-rich subdomains.	Proline	106-113	aryl hydrocarbon receptor	Homo sapiens	47-51
12480180-5	2002	Alanine substitutions for six proline residues located in or near DAT transmembrane domains increase apparent affinity and decrease V(max) values for dopamine efflux mediated by these mutant transporters.	Proline	30-37	solute carrier family 6 member 3	Homo sapiens	66-69
12480812-5	2002	In cultured neonatal rat cardiac fibroblasts, TNF-alpha reduced cellular [3H]-proline incorporation, increased matrix metalloproteinase-2 (MMP-2) activity and protein, and increased TIMP-1 protein levels.	Proline	78-85	tumor necrosis factor	Rattus norvegicus	46-55
12496062-1	2002	An Arg/Pro polymorphism in codon 72 of the TP53 gene was analyzed in blood samples from 390 breast and 162 colorectal cancer patients previously investigated for TP53 mutations in their tumors.	Proline	7-10	tumor protein p53	Homo sapiens	43-47
12480812-6	2002	In cardiac fibroblasts with TNF-alpha-induced AT1 receptor upregulation, Ang II-stimulated [3H]proline incorporation and TIMP-1 protein production was approximately 2-fold greater than in nonpretreated fibroblasts.	Proline	95-102	tumor necrosis factor	Rattus norvegicus	28-37
12480813-6	2002	BNP significantly (P&lt;0.01) inhibited de novo collagen synthesis as assessed by [3H]proline incorporation, whereas zymographic MMP-2 (gelatinase) abundance was significantly (P&lt;0.05) stimulated by BNP between 10(-7) and 10(-6) mol/L.	Proline	86-93	natriuretic peptide B	Canis lupus familiaris	0-3
12468515-13	2002	CONCLUSION: [(111)In-DTPA-Pro(1),Tyr(4)]BN is a promising radioligand for scintigraphy of GRP receptor-expressing tumors.	Proline	26-29	gastrin releasing peptide	Rattus norvegicus	90-93
12466895-2	2002	Here, we report the cloning of the gene encoding human S4D-SRCRB, a novel soluble member of the SRCR-SF, which is composed of four group B SRCR domains separated by Pro-, Ser- and Thr-rich polypeptides.	Proline	165-168	scavenger receptor cysteine rich family member with 4 domains	Homo sapiens	55-64
12504591-2	2002	Using part of the proline-rich region of shank1 in a yeast two hybrid screen, we identified the insulin receptor substrate IRSp53 as an interaction partner.	Proline	18-25	SH3 and multiple ankyrin repeat domains 1	Homo sapiens	41-47
12414939-0	2002	Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation.	Proline	69-76	tegument protein US11	Human alphaherpesvirus 1	92-96
12414939-0	2002	Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation.	Proline	69-76	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	186-189
12414939-1	2002	The herpes simplex virus Us11 gene product inhibits activation of the cellular PKR kinase and associates with a limited number of unrelated viral and cellular RNA molecules via a carboxyl-terminal 68-amino-acid segment rich in arginine and proline.	Proline	240-247	tegument protein US11	Human alphaherpesvirus 1	25-29
12414939-1	2002	The herpes simplex virus Us11 gene product inhibits activation of the cellular PKR kinase and associates with a limited number of unrelated viral and cellular RNA molecules via a carboxyl-terminal 68-amino-acid segment rich in arginine and proline.	Proline	240-247	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	79-82
12414939-13	2002	The arginine- and proline-rich Us11 RNA binding domain is unrelated to known dsRNA binding elements and thus constitutes a unique recognition motif that interacts with dsRNA.	Proline	18-25	tegument protein US11	Human alphaherpesvirus 1	31-35
12451122-2	2002	We screened substitutions of hydrophilic residues exposed in the vestibule and identified a cluster of charged residues and a proline, the DRPEER motif, positioned C terminal to M3, that is unique to the NR1 subunit.	Proline	126-133	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	204-207
12504591-2	2002	Using part of the proline-rich region of shank1 in a yeast two hybrid screen, we identified the insulin receptor substrate IRSp53 as an interaction partner.	Proline	18-25	BAR/IMD domain containing adaptor protein 2	Homo sapiens	123-129
12504591-3	2002	Overlay assays verified a strong interaction between a proline-rich sequence (residues 911-940) in shank1 and the SH3 domain of IRSp53.	Proline	55-62	SH3 and multiple ankyrin repeat domains 1	Homo sapiens	99-105
12504591-3	2002	Overlay assays verified a strong interaction between a proline-rich sequence (residues 911-940) in shank1 and the SH3 domain of IRSp53.	Proline	55-62	BAR/IMD domain containing adaptor protein 2	Homo sapiens	128-134
12382291-5	2002	Two hypotheses have been proposed to explain the catalytic inefficiency of MIF: the lower basicity of primary amines with regard to secondary ones and the increased flexibility resulting from the replacement of a proline by residues like glycine.	Proline	213-220	macrophage migration inhibitory factor	Homo sapiens	75-78
12402030-0	2002	Structural characterization of a proline-driven conformational switch within the Itk SH2 domain.	Proline	33-40	IL2 inducible T cell kinase	Homo sapiens	81-84
12402030-4	2002	To better understand the mechanism by which a proline switch regulates ligand binding, we have used NMR spectroscopy to determine two structures of Itk SH2 corresponding to the cis and trans imide bond-containing conformers.	Proline	46-53	IL2 inducible T cell kinase	Homo sapiens	148-151
12457963-7	2002	However, the proline-rich sequence GPxxPx(6) found within the 11 a.a.-repeats of EBV LMP1 was conserved in Cyno-EBV carboxy tail and contained two consensus JAK/STAT sequences PxxPxP.	Proline	13-20	PDZ and LIM domain 7	Homo sapiens	85-89
12478591-0	2002	Polymorphism of the MPR1 gene required for toxic proline analogue resistance in the Saccharomyces cerevisiae complex species.	Proline	49-56	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	20-24
12478591-1	2002	We recently discovered, on the chromosome of Saccharomyces cerevisiae sigma 1278b, novel MPR1 and MPR2 genes required for resistance to a toxic analogue of L-proline, L-azetidine-2-carboxylic acid.	Proline	156-165	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	89-93
12270922-3	2002	The N-terminal 426 amino acids of both SAF-1 and SAF-2 are identical containing two polyalanine tracts, one proline-rich domain, and six zinc fingers.	Proline	108-115	MYC associated zinc finger protein	Homo sapiens	39-44
12270922-3	2002	The N-terminal 426 amino acids of both SAF-1 and SAF-2 are identical containing two polyalanine tracts, one proline-rich domain, and six zinc fingers.	Proline	108-115	sialic acid binding Ig like lectin 8	Homo sapiens	49-54
12117414-5	2002	In contrast, responses to a collagen-related peptide (CRP), made up of repeat glycine-proline-hydroxyproline motifs, were markedly inhibited and abolished in platelets expressing 50% and 20% of wild-type levels of GPVI respectively.	Proline	86-93	C-reactive protein, pentraxin-related	Mus musculus	28-52
12117414-5	2002	In contrast, responses to a collagen-related peptide (CRP), made up of repeat glycine-proline-hydroxyproline motifs, were markedly inhibited and abolished in platelets expressing 50% and 20% of wild-type levels of GPVI respectively.	Proline	86-93	C-reactive protein, pentraxin-related	Mus musculus	54-57
12473133-3	2002	STUDY DESIGN AND METHODS: DI1 and DI2 alleles result from a single C to T substitution at nucleotide 2561 in exon 19 of the human anion exchanger gene causing a proline (DI1) to leucine (DI2) change at amino acid position 854.	Proline	161-168	arginine vasopressin receptor 2	Homo sapiens	26-29
12473133-3	2002	STUDY DESIGN AND METHODS: DI1 and DI2 alleles result from a single C to T substitution at nucleotide 2561 in exon 19 of the human anion exchanger gene causing a proline (DI1) to leucine (DI2) change at amino acid position 854.	Proline	161-168	arginine vasopressin receptor 2	Homo sapiens	170-173
12297495-5	2002	Indeed, the basic domain of Stra13 contains a proline residue at an unprecedented position.	Proline	46-53	basic helix-loop-helix family member e40	Homo sapiens	28-34
12200420-4	2002	We found that codon 24 proline in the transactivation domain as well as the POU domain of Pit-1 was crucial to recruit coactivator CREB-binding protein (CBP) in the cultured cells.	Proline	23-30	CREB binding protein	Homo sapiens	131-151
12200420-4	2002	We found that codon 24 proline in the transactivation domain as well as the POU domain of Pit-1 was crucial to recruit coactivator CREB-binding protein (CBP) in the cultured cells.	Proline	23-30	CREB binding protein	Homo sapiens	153-156
12200420-7	2002	These results suggest that CBP and proline at codon 24 in the transactivation domain of Pit-1 are important for the cAMP-induced activation of Pit-1-targeted genes.	Proline	35-42	POU class 1 homeobox 1	Homo sapiens	88-93
12200420-7	2002	These results suggest that CBP and proline at codon 24 in the transactivation domain of Pit-1 are important for the cAMP-induced activation of Pit-1-targeted genes.	Proline	35-42	POU class 1 homeobox 1	Homo sapiens	143-148
12393607-3	2002	Here we characterize TLT-1 (TREM-like transcript-1), a putative inhibitory receptor within the TREM cluster that contains an extracellular V-set Ig domain, a proline-rich region, and an immune receptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic tail.	Proline	158-165	triggering receptor expressed on myeloid cells-like 1	Mus musculus	21-26
12393607-3	2002	Here we characterize TLT-1 (TREM-like transcript-1), a putative inhibitory receptor within the TREM cluster that contains an extracellular V-set Ig domain, a proline-rich region, and an immune receptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic tail.	Proline	158-165	triggering receptor expressed on myeloid cells-like 1	Mus musculus	28-50
12426371-2	2002	In T cells, the CD2BP2 adaptor binds two membrane-proximal proline-rich motifs in the CD2 cytoplasmic tail via its GYF domain, thereby regulating interleukin-2 production.	Proline	59-66	CD2 cytoplasmic tail binding protein 2	Homo sapiens	16-22
12221083-7	2002	The human and nematode MIF homologues share a tautomerase enzyme activity, which is in each case abolished by the mutation of the N-terminal proline residue.	Proline	141-148	macrophage migration inhibitory factor	Homo sapiens	23-26
12426371-2	2002	In T cells, the CD2BP2 adaptor binds two membrane-proximal proline-rich motifs in the CD2 cytoplasmic tail via its GYF domain, thereby regulating interleukin-2 production.	Proline	59-66	CD2 molecule	Homo sapiens	16-19
12426378-3	2002	Previous studies proposed the "second-codon rule", according to which the N-terminal proline (Pro) of c-MOS is a destabilizing residue that targets c-MOS for degradation.	Proline	94-97	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	102-107
12426371-2	2002	In T cells, the CD2BP2 adaptor binds two membrane-proximal proline-rich motifs in the CD2 cytoplasmic tail via its GYF domain, thereby regulating interleukin-2 production.	Proline	59-66	interleukin 2	Homo sapiens	146-159
12426378-3	2002	Previous studies proposed the "second-codon rule", according to which the N-terminal proline (Pro) of c-MOS is a destabilizing residue that targets c-MOS for degradation.	Proline	94-97	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	148-153
12426378-4	2002	We analyzed the degradation signal (degron) of c-MOS in Xenopus oocytes, found it to be a portable degron, and demonstrated that, contrary to the model above, the N-terminal Pro residue of c-MOS is entirely dispensable for its degradation if Ser-2 (encoded Ser-3) of c-MOS is replaced by a small non-phosphorylatable residue such as Gly.	Proline	174-177	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	47-52
12426371-5	2002	NMR analysis shows that the Fyn but not the Lck tyrosine kinase SH3 domain competes with CD2BP2 GYF-domain binding to the same CD2 proline-rich sequence in vitro.	Proline	131-138	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
12426378-4	2002	We analyzed the degradation signal (degron) of c-MOS in Xenopus oocytes, found it to be a portable degron, and demonstrated that, contrary to the model above, the N-terminal Pro residue of c-MOS is entirely dispensable for its degradation if Ser-2 (encoded Ser-3) of c-MOS is replaced by a small non-phosphorylatable residue such as Gly.	Proline	174-177	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	189-194
12426378-4	2002	We analyzed the degradation signal (degron) of c-MOS in Xenopus oocytes, found it to be a portable degron, and demonstrated that, contrary to the model above, the N-terminal Pro residue of c-MOS is entirely dispensable for its degradation if Ser-2 (encoded Ser-3) of c-MOS is replaced by a small non-phosphorylatable residue such as Gly.	Proline	174-177	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	189-194
12426371-5	2002	NMR analysis shows that the Fyn but not the Lck tyrosine kinase SH3 domain competes with CD2BP2 GYF-domain binding to the same CD2 proline-rich sequence in vitro.	Proline	131-138	CD2 cytoplasmic tail binding protein 2	Homo sapiens	89-95
12426378-6	2002	Thus, the N-terminal Pro residue of c-MOS is not a recognition determinant for a ubiquitin ligase, in agreement with earlier evidence that Pro is a stabilizing residue in the N-end rule.	Proline	21-24	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	36-41
12426380-3	2002	We reveal that the observed dominant-negative effects of N-WASP are dependent exclusively on the proline-rich domain, the binding interface of syndapins.	Proline	97-104	WASP like actin nucleation promoting factor	Homo sapiens	57-63
12426371-5	2002	NMR analysis shows that the Fyn but not the Lck tyrosine kinase SH3 domain competes with CD2BP2 GYF-domain binding to the same CD2 proline-rich sequence in vitro.	Proline	131-138	CD2 molecule	Homo sapiens	89-92
12426371-6	2002	To test the in vivo significance of this competition, we used co-immunoprecipitation experiments and found that CD2BP2 is the ligand of the membrane-proximal proline-rich tandem repeat of CD2 in detergent-soluble membrane compartments, but is replaced by Fyn SH3 after CD2 is translocated into lipid rafts upon CD2 ectodomain clustering.	Proline	158-165	CD2 cytoplasmic tail binding protein 2	Homo sapiens	112-118
12426371-6	2002	To test the in vivo significance of this competition, we used co-immunoprecipitation experiments and found that CD2BP2 is the ligand of the membrane-proximal proline-rich tandem repeat of CD2 in detergent-soluble membrane compartments, but is replaced by Fyn SH3 after CD2 is translocated into lipid rafts upon CD2 ectodomain clustering.	Proline	158-165	CD2 molecule	Homo sapiens	112-115
12426371-6	2002	To test the in vivo significance of this competition, we used co-immunoprecipitation experiments and found that CD2BP2 is the ligand of the membrane-proximal proline-rich tandem repeat of CD2 in detergent-soluble membrane compartments, but is replaced by Fyn SH3 after CD2 is translocated into lipid rafts upon CD2 ectodomain clustering.	Proline	158-165	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	255-258
12426371-6	2002	To test the in vivo significance of this competition, we used co-immunoprecipitation experiments and found that CD2BP2 is the ligand of the membrane-proximal proline-rich tandem repeat of CD2 in detergent-soluble membrane compartments, but is replaced by Fyn SH3 after CD2 is translocated into lipid rafts upon CD2 ectodomain clustering.	Proline	158-165	CD2 molecule	Homo sapiens	188-191
12426371-6	2002	To test the in vivo significance of this competition, we used co-immunoprecipitation experiments and found that CD2BP2 is the ligand of the membrane-proximal proline-rich tandem repeat of CD2 in detergent-soluble membrane compartments, but is replaced by Fyn SH3 after CD2 is translocated into lipid rafts upon CD2 ectodomain clustering.	Proline	158-165	CD2 molecule	Homo sapiens	188-191
12426378-3	2002	Previous studies proposed the "second-codon rule", according to which the N-terminal proline (Pro) of c-MOS is a destabilizing residue that targets c-MOS for degradation.	Proline	85-92	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	102-107
12426378-3	2002	Previous studies proposed the "second-codon rule", according to which the N-terminal proline (Pro) of c-MOS is a destabilizing residue that targets c-MOS for degradation.	Proline	85-92	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	148-153
12357430-1	2002	Synaptopodin is the first member of a novel class of proline-rich actin-associated proteins.	Proline	53-60	synaptopodin	Mus musculus	0-12
12490321-4	2002	As in Xenopus laevis and Cynops pyrrhogaster there is an additional insertion of approximately 30 amino acids between the prodomain and the catalytic domain, which is poorly conserved between the species and is in human MMP-21 especially proline rich.	Proline	238-245	matrix metallopeptidase 21	Homo sapiens	220-226
12530090-2	2002	The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid codon 72 of the p53 protein.	Proline	114-121	tumor protein p53	Homo sapiens	32-36
12445460-4	2002	Both the N-terminal regulatory domain of annexin XI (Anx11N) and the ALG-2-binding domain of Alix/AIP1 are rich in Pro, Gly, Ala, Tyr and Gln.	Proline	115-118	annexin A11	Homo sapiens	41-51
12445460-4	2002	Both the N-terminal regulatory domain of annexin XI (Anx11N) and the ALG-2-binding domain of Alix/AIP1 are rich in Pro, Gly, Ala, Tyr and Gln.	Proline	115-118	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	69-74
12445460-4	2002	Both the N-terminal regulatory domain of annexin XI (Anx11N) and the ALG-2-binding domain of Alix/AIP1 are rich in Pro, Gly, Ala, Tyr and Gln.	Proline	115-118	programmed cell death 6 interacting protein	Homo sapiens	93-97
12445460-4	2002	Both the N-terminal regulatory domain of annexin XI (Anx11N) and the ALG-2-binding domain of Alix/AIP1 are rich in Pro, Gly, Ala, Tyr and Gln.	Proline	115-118	programmed cell death 6 interacting protein	Homo sapiens	98-102
12530090-2	2002	The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid codon 72 of the p53 protein.	Proline	114-121	tumor protein p53	Homo sapiens	158-161
12530090-2	2002	The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid codon 72 of the p53 protein.	Proline	123-126	tumor protein p53	Homo sapiens	32-36
12530090-2	2002	The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid codon 72 of the p53 protein.	Proline	123-126	tumor protein p53	Homo sapiens	158-161
12384414-7	2002	Bioinformatic analysis of the IL-3 Ralpha and GM Ralpha subunits identified a tripeptide sequence, adjacent to the conserved proline-rich domain, which was potentially a key difference between them.	Proline	125-132	interleukin 3 receptor subunit alpha	Homo sapiens	30-41
12167088-3	2002	Inspection of the sequence of Sab reveals the presence of two putative mitogen-activated protein kinase interaction motifs (KIMs) similar to that found in the JNK docking domain of the c-Jun transcription factor, and four potential serine-proline JNK phosphorylation sites in the C-terminal half of the molecule.	Proline	239-246	SH3 domain binding protein 5	Homo sapiens	30-33
12440954-4	2002	Although the role of MK2 in cytokine expression depends mainly on catalytic activity, its role in cell migration is also dependent on a proline-rich N-terminal motif.	Proline	136-143	MAP kinase-activated protein kinase 2	Mus musculus	21-24
12384414-7	2002	Bioinformatic analysis of the IL-3 Ralpha and GM Ralpha subunits identified a tripeptide sequence, adjacent to the conserved proline-rich domain, which was potentially a key difference between them.	Proline	125-132	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	46-55
12370767-0	2002	Homozygous proline at codon 72 of p53 as a potential risk factor favoring the development of undifferentiated thyroid carcinoma.	Proline	11-18	tumor protein p53	Homo sapiens	34-37
12420205-4	2002	TGF-beta1 codon 10 leucine (Leu) /proline (Pro) polymorphism in donors was associated with the development of aGVHD.	Proline	34-41	transforming growth factor beta 1	Homo sapiens	0-9
12484636-0	2002	Hb Rampa [alpha 95(G2)pro-->Ser (alpha 2)] in a family of European ancestry: DNA analysis confirms the CCG-->TCG mutation at codon 95 of the alpha 2-globin gene; clinical and laboratory features.	Proline	22-25	proline rich coiled-coil 2A	Homo sapiens	0-21
12484636-0	2002	Hb Rampa [alpha 95(G2)pro-->Ser (alpha 2)] in a family of European ancestry: DNA analysis confirms the CCG-->TCG mutation at codon 95 of the alpha 2-globin gene; clinical and laboratory features.	Proline	22-25	glycoprotein hormone subunit alpha 2	Homo sapiens	33-40
12402346-10	2002	Finally we identified a nonsense mutation (R429X) located in the proline rich domain in exon 10 of the FBN1 gene.	Proline	65-72	fibrillin 1	Homo sapiens	103-107
12370767-13	2002	We conclude that homozygous proline is a potential risk factor favoring the development of an undifferentiated thyroid carcinoma, and that the homozygous phenotypes at codon 72 of p53 are associated with a poorer prognosis of thyroid carcinoma.	Proline	28-35	tumor protein p53	Homo sapiens	180-183
12417658-0	2002	Alternative splicing of a beta4 subunit proline-rich motif regulates voltage-dependent gating and toxin block of Cav2.1 Ca2+ channels.	Proline	40-47	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	113-119
12205091-4	2002	In particular, the von Hippel-Lindau (VHL) protein complex, an E3 ubiquitin ligase, binds to the ODD upon hydroxylation of HIF-1alpha Pro-564.	Proline	134-137	von Hippel-Lindau tumor suppressor	Homo sapiens	19-36
12205091-4	2002	In particular, the von Hippel-Lindau (VHL) protein complex, an E3 ubiquitin ligase, binds to the ODD upon hydroxylation of HIF-1alpha Pro-564.	Proline	134-137	von Hippel-Lindau tumor suppressor	Homo sapiens	38-41
12205091-4	2002	In particular, the von Hippel-Lindau (VHL) protein complex, an E3 ubiquitin ligase, binds to the ODD upon hydroxylation of HIF-1alpha Pro-564.	Proline	134-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-133
12391223-3	2002	Our previous studies indicated that in IgA2 lacking Cys(133), a disulfide bond forms between the alpha-chain and the L chain when Cys(220) is followed by Arg(221), but not when Cys(220) is followed by Pro(221), suggesting that the Cys in C(H)1 might be involved in disulfide bonding to the L chain.	Proline	201-204	Fc gamma receptor and transporter	Homo sapiens	97-108
12417658-7	2002	The models (1) reveal that alternative splicing of the beta4 N terminus results in dramatic differences in surface charge distribution and (2) localize the proline-rich motif of beta4b to an extended arm structure that flanks what would be the equivalent of a highly modified PSD-95 carboxylate binding loop.	Proline	156-163	discs large MAGUK scaffold protein 4	Homo sapiens	276-282
12467978-4	2002	Comparison of the amino acid sequence of the alpha3-helix loop7 regions of the two proteins allowed the identification of the proline 96 and threonine 100 amino acid residues of human RHOA as the most probable determinants of the complementation differences.	Proline	126-133	ras homolog family member A	Homo sapiens	184-188
12421375-2	2002	In a yeast two hybrid screen utilizing a proline-rich domain that is highly conserved among the ProSAP/Shank family members, we isolated several cDNA clones coding for the insulin receptor substrate IRSp53.	Proline	41-48	insulin receptor	Rattus norvegicus	172-188
12421375-2	2002	In a yeast two hybrid screen utilizing a proline-rich domain that is highly conserved among the ProSAP/Shank family members, we isolated several cDNA clones coding for the insulin receptor substrate IRSp53.	Proline	41-48	BAR/IMD domain containing adaptor protein 2	Rattus norvegicus	199-205
12421375-5	2002	The C-terminal SH3 domain of IRSp53 is responsible for the interaction with a novel proline-rich consensus sequence of ProSAP/Shank that was characterized by mutational analysis.	Proline	84-91	BAR/IMD domain containing adaptor protein 2	Rattus norvegicus	29-35
12495288-1	2002	BACKGROUND: Human serum IgA1 has a mucin-like structure on its hinge portion which is composed of a mucin-type sugar chain and amino acid sequence rich in proline, serine and threonine.	Proline	155-162	immunoglobulin heavy constant alpha 1	Homo sapiens	24-28
12429845-5	2002	In addition, the proline-rich regions of WASP and Scar1 and the Ena/VASP homology 1 (EVH1) domain of WASP independently enhanced motility rates.	Proline	17-24	WASP actin nucleation promoting factor	Homo sapiens	41-45
12429845-5	2002	In addition, the proline-rich regions of WASP and Scar1 and the Ena/VASP homology 1 (EVH1) domain of WASP independently enhanced motility rates.	Proline	17-24	WASP family member 1	Homo sapiens	50-55
12429845-5	2002	In addition, the proline-rich regions of WASP and Scar1 and the Ena/VASP homology 1 (EVH1) domain of WASP independently enhanced motility rates.	Proline	17-24	WASP actin nucleation promoting factor	Homo sapiens	101-105
12419186-3	2002	Through interactions via its proline-rich domain (PRD), dynamin binds several proteins, including cortactin, profilin, syndapin, and murine Abp1, that regulate the actin cytoskeleton.	Proline	29-36	cortactin	Mus musculus	98-107
12429845-8	2002	WASP- and Scar1-coated bead motility rates were significantly reduced by depletion of profilin and VASP and could be more efficiently rescued by a combination of VASP and wild-type profilin than by VASP and a mutant profilin that cannot bind proline-rich sequences.	Proline	242-249	WASP actin nucleation promoting factor	Homo sapiens	0-5
12429845-8	2002	WASP- and Scar1-coated bead motility rates were significantly reduced by depletion of profilin and VASP and could be more efficiently rescued by a combination of VASP and wild-type profilin than by VASP and a mutant profilin that cannot bind proline-rich sequences.	Proline	242-249	WASP family member 1	Homo sapiens	10-15
12429845-8	2002	WASP- and Scar1-coated bead motility rates were significantly reduced by depletion of profilin and VASP and could be more efficiently rescued by a combination of VASP and wild-type profilin than by VASP and a mutant profilin that cannot bind proline-rich sequences.	Proline	242-249	vasodilator stimulated phosphoprotein	Homo sapiens	99-103
12429845-8	2002	WASP- and Scar1-coated bead motility rates were significantly reduced by depletion of profilin and VASP and could be more efficiently rescued by a combination of VASP and wild-type profilin than by VASP and a mutant profilin that cannot bind proline-rich sequences.	Proline	242-249	vasodilator stimulated phosphoprotein	Homo sapiens	162-166
12429845-8	2002	WASP- and Scar1-coated bead motility rates were significantly reduced by depletion of profilin and VASP and could be more efficiently rescued by a combination of VASP and wild-type profilin than by VASP and a mutant profilin that cannot bind proline-rich sequences.	Proline	242-249	vasodilator stimulated phosphoprotein	Homo sapiens	162-166
12429845-10	2002	Our results suggest that recruitment of factors, including profilin, by the proline-rich regions of WASP and Scar1 and the EVH1 domain of WASP stimulates cellular actin-based motility.	Proline	76-83	WASP actin nucleation promoting factor	Homo sapiens	100-104
12429845-10	2002	Our results suggest that recruitment of factors, including profilin, by the proline-rich regions of WASP and Scar1 and the EVH1 domain of WASP stimulates cellular actin-based motility.	Proline	76-83	WASP family member 1	Homo sapiens	109-114
12374299-0	2002	The proline-rich, extensin-like receptor kinase-1 (PERK1) gene is rapidly induced by wounding.	Proline	4-11	proline extensin-like receptor kinase 1	Arabidopsis thaliana	51-56
12384576-2	2002	Conformational changes induced by phosphotyrosine recognition promote the binding of the Src homology 3 (SH3) domain of the Abl tyrosine kinase to a proline-rich loop located between the betaD and betaE strands of the SH2 domain (DE loop).	Proline	149-156	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	124-127
12419186-3	2002	Through interactions via its proline-rich domain (PRD), dynamin binds several proteins, including cortactin, profilin, syndapin, and murine Abp1, that regulate the actin cytoskeleton.	Proline	29-36	protein kinase C and casein kinase substrate in neurons 1	Mus musculus	119-127
12419186-3	2002	Through interactions via its proline-rich domain (PRD), dynamin binds several proteins, including cortactin, profilin, syndapin, and murine Abp1, that regulate the actin cytoskeleton.	Proline	29-36	amine oxidase, copper-containing 1	Mus musculus	140-144
12181324-4	2002	Three enzymes, prolyl hydroxylase domain-containing proteins 1, 2, and 3 (PHD1, -2, and -3; also known as HIF prolyl hydroxylase 3, 2, and 1, respectively), have recently been identified that catalyze proline hydroxylation of HIF alpha subunits.	Proline	201-208	egl-9 family hypoxia inducible factor 2	Homo sapiens	15-72
12186875-2	2002	Here, employing a novel hydroxylation-specific antibody, we directly show that proline 564 of HIF-1alpha and proline 531 of HIF-2alpha are hydroxylated under normoxia.	Proline	79-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-104
12186875-2	2002	Here, employing a novel hydroxylation-specific antibody, we directly show that proline 564 of HIF-1alpha and proline 531 of HIF-2alpha are hydroxylated under normoxia.	Proline	79-86	endothelial PAS domain protein 1	Homo sapiens	124-134
12186875-2	2002	Here, employing a novel hydroxylation-specific antibody, we directly show that proline 564 of HIF-1alpha and proline 531 of HIF-2alpha are hydroxylated under normoxia.	Proline	109-116	endothelial PAS domain protein 1	Homo sapiens	124-134
12397361-3	2002	Here we report that DNA damage specifically induces p53 phosphorylation on Ser/Thr-Pro motifs, which facilitates its interaction with Pin1, a member of peptidyl-prolyl isomerase.	Proline	83-86	tumor protein p53	Homo sapiens	52-55
12397361-3	2002	Here we report that DNA damage specifically induces p53 phosphorylation on Ser/Thr-Pro motifs, which facilitates its interaction with Pin1, a member of peptidyl-prolyl isomerase.	Proline	83-86	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	134-138
12181324-4	2002	Three enzymes, prolyl hydroxylase domain-containing proteins 1, 2, and 3 (PHD1, -2, and -3; also known as HIF prolyl hydroxylase 3, 2, and 1, respectively), have recently been identified that catalyze proline hydroxylation of HIF alpha subunits.	Proline	201-208	egl-9 family hypoxia inducible factor 2	Homo sapiens	74-90
12181324-4	2002	Three enzymes, prolyl hydroxylase domain-containing proteins 1, 2, and 3 (PHD1, -2, and -3; also known as HIF prolyl hydroxylase 3, 2, and 1, respectively), have recently been identified that catalyze proline hydroxylation of HIF alpha subunits.	Proline	201-208	egl-9 family hypoxia inducible factor 3	Homo sapiens	106-140
12181324-8	2002	Thus, these results provide evidence that the only obligatory residue for proline hydroxylation in HIF-1alpha is the hydroxylacceptor proline itself.	Proline	74-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109
12379220-4	2002	The predicted full-length Drosophila rpL22 protein has an N-terminal extension rich in alanine, lysine, and proline that appears to be unique to Drosophila.	Proline	108-115	Ribosomal protein L22	Drosophila melanogaster	37-42
12186875-3	2002	Importantly, HIF-1alpha Pro-564 and HIF-2alpha Pro-531 hydroxylation is diminished with the treatment of hypoxia, cobalt chloride, desferrioxamine, or dimethyloxalyglycine, regardless of the E3 ubiquitin ligase activity of the von Hippel-Lindau (VHL) tumor suppressor gene.	Proline	24-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
12181324-8	2002	Thus, these results provide evidence that the only obligatory residue for proline hydroxylation in HIF-1alpha is the hydroxylacceptor proline itself.	Proline	134-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109
12186875-3	2002	Importantly, HIF-1alpha Pro-564 and HIF-2alpha Pro-531 hydroxylation is diminished with the treatment of hypoxia, cobalt chloride, desferrioxamine, or dimethyloxalyglycine, regardless of the E3 ubiquitin ligase activity of the von Hippel-Lindau (VHL) tumor suppressor gene.	Proline	47-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
12149250-6	2002	The carboxyl-terminal region containing the proline-rich motifs of POB1 directly bound to the carboxyl-terminal region including the SH3 domain of PAG2.	Proline	44-51	RALBP1 associated Eps domain containing 2	Homo sapiens	67-71
12186875-3	2002	Importantly, HIF-1alpha Pro-564 and HIF-2alpha Pro-531 hydroxylation is diminished with the treatment of hypoxia, cobalt chloride, desferrioxamine, or dimethyloxalyglycine, regardless of the E3 ubiquitin ligase activity of the von Hippel-Lindau (VHL) tumor suppressor gene.	Proline	47-50	endothelial PAS domain protein 1	Homo sapiens	36-46
12186875-4	2002	Furthermore, in VHL-deficient cells, HIF-1alpha Pro-564 and HIF-2alpha Pro-531 had detectable amounts of hydroxylation following transition to hypoxia, indicating that the post-translational modification is not reversible.	Proline	48-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
12186875-4	2002	Furthermore, in VHL-deficient cells, HIF-1alpha Pro-564 and HIF-2alpha Pro-531 had detectable amounts of hydroxylation following transition to hypoxia, indicating that the post-translational modification is not reversible.	Proline	71-74	endothelial PAS domain protein 1	Homo sapiens	60-70
12374763-3	2002	The gene encoding sequestosome 1 (SQSTM1/p62) maps to within the PDB3 critical region, and recent studies have identified a proline-leucine amino acid change at codon 392 of SQSTM1 (P392L) in French-Canadian patients with PDB.	Proline	124-131	sequestosome 1	Homo sapiens	18-32
12374763-3	2002	The gene encoding sequestosome 1 (SQSTM1/p62) maps to within the PDB3 critical region, and recent studies have identified a proline-leucine amino acid change at codon 392 of SQSTM1 (P392L) in French-Canadian patients with PDB.	Proline	124-131	sequestosome 1	Homo sapiens	34-40
12374763-3	2002	The gene encoding sequestosome 1 (SQSTM1/p62) maps to within the PDB3 critical region, and recent studies have identified a proline-leucine amino acid change at codon 392 of SQSTM1 (P392L) in French-Canadian patients with PDB.	Proline	124-131	sequestosome 1	Homo sapiens	41-44
12374763-3	2002	The gene encoding sequestosome 1 (SQSTM1/p62) maps to within the PDB3 critical region, and recent studies have identified a proline-leucine amino acid change at codon 392 of SQSTM1 (P392L) in French-Canadian patients with PDB.	Proline	124-131	sequestosome 1	Homo sapiens	174-180
12149250-6	2002	The carboxyl-terminal region containing the proline-rich motifs of POB1 directly bound to the carboxyl-terminal region including the SH3 domain of PAG2.	Proline	44-51	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	147-151
12149250-10	2002	These results suggest that POB1 interacts with PAG2 through its proline-rich motif, thereby regulating cell migration.	Proline	64-71	RALBP1 associated Eps domain containing 2	Homo sapiens	27-31
12149250-10	2002	These results suggest that POB1 interacts with PAG2 through its proline-rich motif, thereby regulating cell migration.	Proline	64-71	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	47-51
12209469-4	2002	NMR spectra indicated the coexistence of trans and cis isomers of the Trp(3)-Pro(4) bond.	Proline	77-80	tRNA-Pro (anticodon TGG) 3-1	Homo sapiens	70-76
12140287-1	2002	Regulated intracellular localization of Gln3, the transcriptional activator responsible for nitrogen catabolite repression (NCR)-sensitive transcription, permits Saccharomyces cerevisiae to utilize good nitrogen sources (e.g. glutamine and ammonia) in preference to poor ones (e.g. proline).	Proline	282-289	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	40-44
12426103-2	2002	RhoBTB proteins are characterized by a modular organization, consisting of a GTPase (guanosine triphosphatase) domain, a proline rich region, a tandem of two BTB (Broad-Complex, Tramtrack, and Bric a brac) domains and a C-terminal region of unknown function and might act as docking points for multiple components participating in signal transduction cascades.	Proline	121-128	Rho-related BTB domain containing	Drosophila melanogaster	0-6
12354621-1	2002	CIN85 and CMS belong to a family of ubiquitously expressed adaptor molecules containing three SH3 domains, a proline-rich region and a coiled-coil domain.	Proline	109-116	SH3 domain containing kinase binding protein 1	Homo sapiens	0-5
12360406-1	2002	p95 is a putative signal transduction protein of approximately 95 kDa that contains multiple tyrosine residues that are conserved from yeast to human, a Src phosphorylation consensus sequence and a proline-rich C-terminus that binds SH3-domains.	Proline	198-205	nibrin	Homo sapiens	0-3
12359760-5	2002	A unique point mutation effected a nonconservative substitution of a leucine for a proline residue at a structurally important site in neo-PAP that was remote from the recognized peptide, revealing a normally silent epitope for immune recognition.	Proline	83-90	poly(A) polymerase gamma	Homo sapiens	135-142
12438171-11	2002	Studies of NET gene structure revealed a coding mutation converting a conserved alanine residue in transmembrane domain 9 to proline.	Proline	125-132	solute carrier family 6 member 2	Homo sapiens	11-14
12228288-6	2002	A purified recombinant protein derivative of PspC that lacked the proline-rich region (PspCDeltaPro) had a reduced binding efficiency for fH, thereby directly showing the importance of this region for the fH interaction.	Proline	66-73	surfactant protein C	Homo sapiens	45-49
12065086-3	2002	The p53 codon 72 Arg/Pro polymorphism has been suggested to be associated with susceptibility to tobacco-related cancers, but this association remains controversial.	Proline	21-24	tumor protein p53	Homo sapiens	4-7
12477976-10	2002	DERPC encoded a strong basic, proline- and glycine-rich nuclear protein.	Proline	30-37	chromosome transmission fidelity factor 8	Homo sapiens	0-5
12376638-0	2002	ACTCAT, a novel cis-acting element for proline- and hypoosmolarity-responsive expression of the ProDH gene encoding proline dehydrogenase in Arabidopsis.	Proline	39-46	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	96-101
12376638-0	2002	ACTCAT, a novel cis-acting element for proline- and hypoosmolarity-responsive expression of the ProDH gene encoding proline dehydrogenase in Arabidopsis.	Proline	39-46	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	116-137
12376638-2	2002	We previously isolated from Arabidopsis a gene encoding Pro dehydrogenase (ProDH), a mitochondrial enzyme involved in the first step of the conversion of Pro to glutamic acid.	Proline	56-59	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	75-80
12376638-4	2002	ProDH is also induced by L-Pro and hypoosmolarity.	Proline	25-30	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	0-5
12376638-6	2002	We analyzed a DNA region that is located 5" to the transcription start site (a promoter region) of ProDH to identify cis-acting elements involved in L-Pro-induced and hypoosmolarity-induced expression in transgenic tobacco (Nicotiana tabacum) and Arabidopsis plants.	Proline	149-154	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	99-104
12376638-7	2002	We found that a 9-bp sequence, ACTCATCCT, in the ProDH promoter is necessary for the efficient expression of ProDH in response to L-Pro and hypoosmolarity.	Proline	130-135	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	49-54
12376638-7	2002	We found that a 9-bp sequence, ACTCATCCT, in the ProDH promoter is necessary for the efficient expression of ProDH in response to L-Pro and hypoosmolarity.	Proline	130-135	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	109-114
12376638-8	2002	Moreover, ACTCAT is a core cis-acting element, which we have called Pro- or hypoosmolarity-responsive element (PRE), that is necessary for L-Pro-responsive and hypoosmolarity-responsive expression of ProDH.	Proline	139-144	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	200-205
12368717-4	2002	The proline residue at codon 72 of the p53 gene was significantly over represented in the POAG patients relative to healthy controls.	Proline	4-11	tumor protein p53	Homo sapiens	39-42
12368717-12	2002	CONCLUSIONS: Association between the p53 gene encoding for proline at codon 72 and POAG presumably exists in some ethnic populations but cannot be used as a predictor for the role of the gene as a common regulator of cell death of retinal ganglions leading to POAG.	Proline	59-66	tumor protein p53	Homo sapiens	37-40
12270821-1	2002	Pseudomonas aeruginosa PAO1 utilizes proline as the sole source of carbon and nitrogen via a bifunctional enzyme (the putA gene product) that has both proline dehydrogenase (EC 1.5.99.8) and pyrroline 5-carboxylate dehydrogenase (EC 1.5.1.12) activities.	Proline	37-44	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase	Pseudomonas aeruginosa PAO1	118-122
12270821-7	2002	This gene appeared to be dispensable for proline utilization as indicated by the normal growth of a knockout mutant of PA0781 on medium containing proline.	Proline	147-154	hypothetical protein	Pseudomonas aeruginosa PAO1	119-125
12270821-8	2002	The pruR (proline utilization regulator) gene immediately upstream of PA0781 encoded a transcriptional activator of the AraC/XylS protein family and mediated the proline-responsive expression of putAP.	Proline	10-17	hypothetical protein	Pseudomonas aeruginosa PAO1	70-76
12270821-8	2002	The pruR (proline utilization regulator) gene immediately upstream of PA0781 encoded a transcriptional activator of the AraC/XylS protein family and mediated the proline-responsive expression of putAP.	Proline	162-169	hypothetical protein	Pseudomonas aeruginosa PAO1	70-76
12359332-7	2002	The CHPPR cDNA has a complete open reading frame coding for a polypeptide with a calculated mass of 35.6 kDa containing a proline-rich region with a PPLP motif (single-letter amino acid code).	Proline	122-129	mitochondrial fission regulator 1	Gallus gallus	4-9
12084720-8	2002	The results from sequencing analysis showed that the hMAK protein is 623 amino acids in length and contains a kinase catalytic domain at its N terminus, followed by a proline/glutamine-rich domain.	Proline	167-174	male germ cell associated kinase	Homo sapiens	53-57
12270713-5	2002	Previously, we solved the NMR structure of the central proline-rich P-domain of CRT comprising residues 189-288.	Proline	55-62	calreticulin	Homo sapiens	80-83
12297296-8	2002	Mutagenesis of a potential proline-directed kinase phosphorylation site in munc18c, T569, that in previous studies of its neuronal counterpart munc18a caused its dissociation from its complex with syntaxin 1a, had no effect on munc18c"s association with syntaxin 4 or its inhibition of glucose transport, indicative that phosphorylation of this residue is not important for insulin regulation of glucose transport.	Proline	27-34	syntaxin binding protein 3	Mus musculus	75-82
12297296-8	2002	Mutagenesis of a potential proline-directed kinase phosphorylation site in munc18c, T569, that in previous studies of its neuronal counterpart munc18a caused its dissociation from its complex with syntaxin 1a, had no effect on munc18c"s association with syntaxin 4 or its inhibition of glucose transport, indicative that phosphorylation of this residue is not important for insulin regulation of glucose transport.	Proline	27-34	syntaxin binding protein 1	Mus musculus	143-150
12297296-8	2002	Mutagenesis of a potential proline-directed kinase phosphorylation site in munc18c, T569, that in previous studies of its neuronal counterpart munc18a caused its dissociation from its complex with syntaxin 1a, had no effect on munc18c"s association with syntaxin 4 or its inhibition of glucose transport, indicative that phosphorylation of this residue is not important for insulin regulation of glucose transport.	Proline	27-34	syntaxin 1A (brain)	Mus musculus	197-208
12297296-8	2002	Mutagenesis of a potential proline-directed kinase phosphorylation site in munc18c, T569, that in previous studies of its neuronal counterpart munc18a caused its dissociation from its complex with syntaxin 1a, had no effect on munc18c"s association with syntaxin 4 or its inhibition of glucose transport, indicative that phosphorylation of this residue is not important for insulin regulation of glucose transport.	Proline	27-34	syntaxin binding protein 3	Mus musculus	227-234
12297296-8	2002	Mutagenesis of a potential proline-directed kinase phosphorylation site in munc18c, T569, that in previous studies of its neuronal counterpart munc18a caused its dissociation from its complex with syntaxin 1a, had no effect on munc18c"s association with syntaxin 4 or its inhibition of glucose transport, indicative that phosphorylation of this residue is not important for insulin regulation of glucose transport.	Proline	27-34	syntaxin 4A (placental)	Mus musculus	254-264
12297299-5	2002	This interaction is mediated by the N-terminal proline-rich region of U2AF65 and does not involve the U2AF65 RRMs.	Proline	47-54	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	70-76
12237104-6	2002	When fused to GST, maltose-binding protein, or the WAVE1 proline-rich domain, N-WASP VCA and WAVE1 VCA mutant proteins with two V motifs showed stronger activities than wild-type WAVE1 VCA with one V motif, demonstrating the importance of two V motifs for strong VCA activity.	Proline	57-64	WASP family member 1	Homo sapiens	51-56
12119297-13	2002	MMP-26 cleaved Phe(352)-Leu(353) and Pro(357)-Met(358) in the reactive loop of alpha(1)-proteinase inhibitor and His(140)-Val(141) in insulin-like growth factor-binding protein-1, probably rendering these substrates inactive.	Proline	37-40	matrix metallopeptidase 26	Homo sapiens	0-6
12237104-6	2002	When fused to GST, maltose-binding protein, or the WAVE1 proline-rich domain, N-WASP VCA and WAVE1 VCA mutant proteins with two V motifs showed stronger activities than wild-type WAVE1 VCA with one V motif, demonstrating the importance of two V motifs for strong VCA activity.	Proline	57-64	WASP like actin nucleation promoting factor	Homo sapiens	78-84
12372256-6	2002	The WH1 domain, which is predicted to have a similar structural fold to the Ena/VASP homology 1 (EVH1) domain, binds to a sequence motif in WIP (ESRFYFHPISD) that is very different from the EVH1 proline-rich DL/FPPPP ligand.	Proline	195-202	WAS/WASL interacting protein family member 1	Homo sapiens	140-143
12223544-7	2002	SH3-dependent binding of Src leads to the suppression of both Kv1.5 and Kv1.4 (modified to contain proline-rich SH3 domain binding sites) macroscopic currents even in the absence of Src-catalyzed tyrosine phosphorylation, whereas binding-independent tyrosine phosphorylation by Src leads to the suppression of Kv1.5 macroscopic currents and the modulation of Kv1.4 inactivation kinetics.	Proline	99-106	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	25-28
12217952-4	2002	In addition, two heterozygous PRODH missense mutations (L441P and L289M), detected in 3 of 63 schizophrenic patients but in none among 68 controls, were also associated with increased plasma proline levels.	Proline	191-198	proline dehydrogenase 1	Homo sapiens	30-35
12223544-7	2002	SH3-dependent binding of Src leads to the suppression of both Kv1.5 and Kv1.4 (modified to contain proline-rich SH3 domain binding sites) macroscopic currents even in the absence of Src-catalyzed tyrosine phosphorylation, whereas binding-independent tyrosine phosphorylation by Src leads to the suppression of Kv1.5 macroscopic currents and the modulation of Kv1.4 inactivation kinetics.	Proline	99-106	potassium voltage-gated channel subfamily A member 5	Homo sapiens	62-67
12223544-7	2002	SH3-dependent binding of Src leads to the suppression of both Kv1.5 and Kv1.4 (modified to contain proline-rich SH3 domain binding sites) macroscopic currents even in the absence of Src-catalyzed tyrosine phosphorylation, whereas binding-independent tyrosine phosphorylation by Src leads to the suppression of Kv1.5 macroscopic currents and the modulation of Kv1.4 inactivation kinetics.	Proline	99-106	potassium voltage-gated channel subfamily A member 4	Homo sapiens	72-77
12223544-7	2002	SH3-dependent binding of Src leads to the suppression of both Kv1.5 and Kv1.4 (modified to contain proline-rich SH3 domain binding sites) macroscopic currents even in the absence of Src-catalyzed tyrosine phosphorylation, whereas binding-independent tyrosine phosphorylation by Src leads to the suppression of Kv1.5 macroscopic currents and the modulation of Kv1.4 inactivation kinetics.	Proline	99-106	potassium voltage-gated channel subfamily A member 5	Homo sapiens	310-315
12223544-7	2002	SH3-dependent binding of Src leads to the suppression of both Kv1.5 and Kv1.4 (modified to contain proline-rich SH3 domain binding sites) macroscopic currents even in the absence of Src-catalyzed tyrosine phosphorylation, whereas binding-independent tyrosine phosphorylation by Src leads to the suppression of Kv1.5 macroscopic currents and the modulation of Kv1.4 inactivation kinetics.	Proline	99-106	potassium voltage-gated channel subfamily A member 4	Homo sapiens	359-364
12194921-4	2002	RESULTS: Western blot analyses with NH(2)-terminus-truncated L-PGDS mapped the epitopes to Ala(23)-Val(28) (MAb-7F5 and -10A3), Ser(52)-Ala(73) (MAb-9A6), Tyr(107)-Val(120) (MAb-1B7 and -6F5), and Gly(140)-Pro(155) (MAb-6B9).	Proline	206-209	prostaglandin D2 synthase	Homo sapiens	61-67
12220521-0	2002	The structure of an endomorphin analogue incorporating 1-aminocyclohexane-1-carboxlylic acid for proline is similar to the beta-turn of Leu-enkephalin.	Proline	97-104	prodynorphin	Homo sapiens	136-150
12121988-9	2002	A proline-rich peptide activates Brk, suggesting that the SH3 domain is also involved in maintaining an inactive form of Brk.	Proline	2-9	protein tyrosine kinase 6	Homo sapiens	33-36
12121988-9	2002	A proline-rich peptide activates Brk, suggesting that the SH3 domain is also involved in maintaining an inactive form of Brk.	Proline	2-9	protein tyrosine kinase 6	Homo sapiens	121-124
12181125-1	2002	DeltaKPQ, a three amino acid [lysine (K), proline (P), glutamine (Q)] deletion mutation of the human cardiac Na channel (hH1), which is one cause of long QT syndrome (LQT3), has impaired inactivation resulting in a late sodium current.	Proline	42-49	H1.5 linker histone, cluster member	Homo sapiens	121-124
12027806-6	2002	A similar cleavage sequence (Phe-Arg-Pro-Gly downward arrow Ser-Val-Val-Val, where downward arrow signifies the cleavage site) has been reported in human MUC1 and analogous sites are present in human MUC3, MUC12 and MUC17.	Proline	37-40	mucin 1, cell surface associated	Homo sapiens	154-158
12027806-6	2002	A similar cleavage sequence (Phe-Arg-Pro-Gly downward arrow Ser-Val-Val-Val, where downward arrow signifies the cleavage site) has been reported in human MUC1 and analogous sites are present in human MUC3, MUC12 and MUC17.	Proline	37-40	MUC3	Homo sapiens	200-204
12027806-6	2002	A similar cleavage sequence (Phe-Arg-Pro-Gly downward arrow Ser-Val-Val-Val, where downward arrow signifies the cleavage site) has been reported in human MUC1 and analogous sites are present in human MUC3, MUC12 and MUC17.	Proline	37-40	mucin 12, cell surface associated	Homo sapiens	206-211
12027806-6	2002	A similar cleavage sequence (Phe-Arg-Pro-Gly downward arrow Ser-Val-Val-Val, where downward arrow signifies the cleavage site) has been reported in human MUC1 and analogous sites are present in human MUC3, MUC12 and MUC17.	Proline	37-40	mucin 17, cell surface associated	Homo sapiens	216-221
12189163-8	2002	Molecular study of the fibulin-5 (FBLN5) gene in a large consanguineous Turkish family with four patients affected by AR cutis laxa type I demonstrated the presence of a homozygous missense mutation (T998C) in the FBLN5 gene resulting in a serine-to-proline (S227P) substitution in the fourth calcium-binding epidermal growth factor-like domain of fibulin-5 protein.	Proline	250-257	fibulin 5	Homo sapiens	23-32
12198706-9	2002	CONCLUSIONS: Several DQ2-restricted T-cell epitopes exist in gliadin that are located in regions rich in proline.	Proline	105-112	torsin family 1 member A	Homo sapiens	21-24
12189163-8	2002	Molecular study of the fibulin-5 (FBLN5) gene in a large consanguineous Turkish family with four patients affected by AR cutis laxa type I demonstrated the presence of a homozygous missense mutation (T998C) in the FBLN5 gene resulting in a serine-to-proline (S227P) substitution in the fourth calcium-binding epidermal growth factor-like domain of fibulin-5 protein.	Proline	250-257	fibulin 5	Homo sapiens	34-39
12189163-8	2002	Molecular study of the fibulin-5 (FBLN5) gene in a large consanguineous Turkish family with four patients affected by AR cutis laxa type I demonstrated the presence of a homozygous missense mutation (T998C) in the FBLN5 gene resulting in a serine-to-proline (S227P) substitution in the fourth calcium-binding epidermal growth factor-like domain of fibulin-5 protein.	Proline	250-257	fibulin 5	Homo sapiens	214-219
12202403-7	2002	Finally, the mouse homolog of human TLR3 identified here may, like its human counterpart, be an exceptional TLR molecule due to its lack of a conserved proline residue seen to be involved in existing TLR signaling capabilities found in other TLR family members.	Proline	152-159	toll like receptor 3	Homo sapiens	36-40
12193705-3	2002	The FDC-SP gene lies on chromosome 4q13 adjacent to clusters of proline-rich salivary peptides and C-X-C chemokines.	Proline	64-71	follicular dendritic cell secreted protein	Homo sapiens	4-10
12358749-3	2002	All nadrin variants share the GAP domain, coiled-coil domain, serine/threonine/proline-rich domain, SH3-binding motif, and a successive repeat of 29 glutamines.	Proline	79-86	Rho GTPase activating protein 17	Rattus norvegicus	4-10
12352668-8	2002	RESULTS: Molecular analyses revealed a nonfunctional germline point mutation within exon 2 of the p16 gene that encodes a mutant p16 protein substituting proline at amino acid position 87 for the wild-type arginine (p16R87P).	Proline	154-161	cyclin dependent kinase inhibitor 2A	Homo sapiens	98-101
12352668-8	2002	RESULTS: Molecular analyses revealed a nonfunctional germline point mutation within exon 2 of the p16 gene that encodes a mutant p16 protein substituting proline at amino acid position 87 for the wild-type arginine (p16R87P).	Proline	154-161	cyclin dependent kinase inhibitor 2A	Homo sapiens	129-132
12192078-8	2002	Changing the P4" residue of alpha(1)-PI-LGR Pro to Glu reduced the activity with C1s, consistent with the idea that C1s requires hydrophobic residues in this region of the serpin for optimal interaction.	Proline	44-47	complement C1s	Homo sapiens	81-84
12220262-3	2002	To examine this possibility more closely, intracellular proline level was manipulated by expressing mutated derivatives of tomPRO2 (a Delta(1)-pyrroline-5-carboxylate synthetase, P5CS, from tomato) in Saccharomyces cerevisiae.	Proline	56-63	delta-1-pyrroline-5-carboxylate synthase	Solanum lycopersicum	123-177
12192078-8	2002	Changing the P4" residue of alpha(1)-PI-LGR Pro to Glu reduced the activity with C1s, consistent with the idea that C1s requires hydrophobic residues in this region of the serpin for optimal interaction.	Proline	44-47	complement C1s	Homo sapiens	116-119
12176012-1	2002	Homer proteins bind to a proline-rich region of the group I metabotropic glutamate receptors (mGluRs) and control their expression and localization at the excitatory postsynaptic density.	Proline	25-32	glutamate receptor, metabotropic 5	Mus musculus	94-100
12097317-10	2002	NEIL2 is similar to NEIL1 in having N-terminal Pro as the active site.	Proline	47-50	nei like DNA glycosylase 2	Homo sapiens	0-5
12097317-10	2002	NEIL2 is similar to NEIL1 in having N-terminal Pro as the active site.	Proline	47-50	nei like DNA glycosylase 1	Homo sapiens	20-25
12163161-0	2002	The proline rich region of the Tec homology domain of ITK regulates its activity.	Proline	4-11	IL2 inducible T cell kinase	Homo sapiens	54-57
12186852-1	2002	The COOH-terminal tail of mammalian neurofilament heavy subunit (NF-H), the largest neurofilament subunit, contains 44-51 lysine-serine-proline repeats that are nearly stoichiometrically phosphorylated after assembly into neurofilaments in axons.	Proline	136-143	neurofilament, heavy polypeptide	Mus musculus	36-63
12186852-1	2002	The COOH-terminal tail of mammalian neurofilament heavy subunit (NF-H), the largest neurofilament subunit, contains 44-51 lysine-serine-proline repeats that are nearly stoichiometrically phosphorylated after assembly into neurofilaments in axons.	Proline	136-143	neurofilament heavy chain	Homo sapiens	65-69
12163161-5	2002	We found that deletion of the proline rich sequence found in the Tec homology domain of ITK results in reduced basal activity of ITK approximately 50%.	Proline	30-37	IL2 inducible T cell kinase	Homo sapiens	88-91
12163161-5	2002	We found that deletion of the proline rich sequence found in the Tec homology domain of ITK results in reduced basal activity of ITK approximately 50%.	Proline	30-37	IL2 inducible T cell kinase	Homo sapiens	129-132
12193273-3	2002	RESULTS: Truncation and mutagenesis approaches showed that the RACK1-interacting domain on PDE4D5 comprised a cluster of residues provided by Asn-22/Pro-23/Trp-24/Asn-26 together with a series of hydrophobic amino acids, namely Leu-29, Val-30, Leu-33, Leu-37 and Leu-38 in a "Leu-Xaa-Xaa-Xaa-Leu" repeat.	Proline	149-152	receptor for activated C kinase 1	Mus musculus	63-68
12163023-3	2002	Under normoxia, two highly conserved proline residues within the oxygen-dependent degradation domain (ODDD) are hydroxylated by oxoglutarate-dependent proline 4-hydroxylases EGLN1-3.	Proline	37-44	egl-9 family hypoxia inducible factor 1	Homo sapiens	174-179
12163023-6	2002	Like EGLNs, PH-4 overexpressed in cellular reporter assays suppressed the HIF transactivation activity, dependent on the consensus ODDD proline residues.	Proline	136-143	prolyl 4-hydroxylase, transmembrane	Homo sapiens	12-16
12163161-9	2002	These results suggest that the proline rich region within the Tec homology domain of ITK regulates its basal activity and its response to Src family kinase signals.	Proline	31-38	IL2 inducible T cell kinase	Homo sapiens	85-88
12034747-3	2002	This part of Alix contains a long proline-rich domain containing several potential SH3-binding sites.	Proline	34-41	programmed cell death 6 interacting protein	Mus musculus	13-17
12163161-9	2002	These results suggest that the proline rich region within the Tec homology domain of ITK regulates its basal activity and its response to Src family kinase signals.	Proline	31-38	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	138-141
12034747-5	2002	Co-immunoprecipitations and overlay experiments allowed us to demonstrate that endophilins bind to Alix-CT through an SH3/proline-rich domain interaction.	Proline	122-129	programmed cell death 6 interacting protein	Mus musculus	99-103
12124396-3	2002	One sequence was adjacent to and the other coincided with the two proline residues of the oxygen-dependent degradation domain (P402 and P564) that act as switches for the oxygen-dependent regulation of HIF-1alpha.	Proline	66-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	202-212
12196126-1	2002	All the IgA1 proteases of the different pathogenic species of Streptococcus cleave the hinge of the alpha chain of human IgA1 only at one proline-threonine peptide bond.	Proline	138-145	immunoglobulin heavy constant alpha 1	Homo sapiens	8-12
11996670-7	2002	The DAL-1/Protein 4.1B domain that mediates 14-3-3 binding was mapped to residues Pro(244) and Leu(280) within the 4.1/ezrin/radixin/moesin domain.	Proline	10-13	erythrocyte membrane protein band 4.1 like 3	Homo sapiens	4-9
12124396-7	2002	The binding data support the proposal that p53 provides a route for the degradation in hypoxic tumor cells of HIF-1alpha that is not hydroxylated at the two proline residues.	Proline	157-164	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-120
12186408-1	2002	Prolyl endopeptidase (PEP, EC 3.4.21.26) has been proposed to play a role in degradation of proline-containing neuropeptides involved in the processes of learning and memory, e.g., vasopressin, substance P, and thyrotropin-releasing hormone (TRH).	Proline	92-99	prolyl endopeptidase	Rattus norvegicus	0-20
12186408-1	2002	Prolyl endopeptidase (PEP, EC 3.4.21.26) has been proposed to play a role in degradation of proline-containing neuropeptides involved in the processes of learning and memory, e.g., vasopressin, substance P, and thyrotropin-releasing hormone (TRH).	Proline	92-99	prolyl endopeptidase	Rattus norvegicus	22-25
12186408-1	2002	Prolyl endopeptidase (PEP, EC 3.4.21.26) has been proposed to play a role in degradation of proline-containing neuropeptides involved in the processes of learning and memory, e.g., vasopressin, substance P, and thyrotropin-releasing hormone (TRH).	Proline	92-99	arginine vasopressin	Rattus norvegicus	181-192
12186408-1	2002	Prolyl endopeptidase (PEP, EC 3.4.21.26) has been proposed to play a role in degradation of proline-containing neuropeptides involved in the processes of learning and memory, e.g., vasopressin, substance P, and thyrotropin-releasing hormone (TRH).	Proline	92-99	thyrotropin releasing hormone	Rattus norvegicus	211-240
12196126-1	2002	All the IgA1 proteases of the different pathogenic species of Streptococcus cleave the hinge of the alpha chain of human IgA1 only at one proline-threonine peptide bond.	Proline	138-145	immunoglobulin heavy constant alpha 1	Homo sapiens	121-125
12101225-3	2002	Interestingly, the pSer/Thr-Pro motifs in proteins exist in two completely distinct cis and trans conformations, whose conversion is catalyzed specifically by the essential prolyl isomerase Pin1.	Proline	28-31	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	190-194
12130528-5	2002	Several sequence variants were identified within the TfR2 gene, including a homozygous missense change in exon 17, c2069 A--&gt;C, which changes a glutamine to a proline residue at position 690.	Proline	162-169	transferrin receptor 2	Homo sapiens	53-57
12144822-7	2002	The frequency of distribution of the three genotypes of p53 codon 72 in a subgroup of the HPV16/18-positive cervical cancer patients was Pro/Pro 0.18 and Arg/Arg 0.26, with the heterozygous Pro/Arg 0.56, differing significantly from the genotype frequency in the normal healthy women (chi(2) = 6.928, df = 2, P &lt; 0.05).	Proline	141-144	tumor protein p53	Homo sapiens	56-59
12358803-3	2002	Mammals express four isoforms of Numb that differ in the length of a phosphotyrosine-binding (PTB) domain and a proline-rich region (PRR).	Proline	112-119	NUMB, endocytic adaptor protein	Rattus norvegicus	33-37
12237513-2	2002	The Vmax of Na(+)-dependent proline uptake remarkably increased with a dose-dependent manner of EGF, while Km did not change.	Proline	28-35	epidermal growth factor like 1	Rattus norvegicus	96-99
12237513-4	2002	These results suggested that EGF enhanced proline transport activity in placental microvillous membranes, resulting in an increase of proline concentration in the fetal blood.	Proline	42-49	epidermal growth factor like 1	Rattus norvegicus	29-32
12237513-4	2002	These results suggested that EGF enhanced proline transport activity in placental microvillous membranes, resulting in an increase of proline concentration in the fetal blood.	Proline	134-141	epidermal growth factor like 1	Rattus norvegicus	29-32
12237513-5	2002	The selective up-regulation of proline uptake was considered to contribute to fetal growth by EGF.	Proline	31-38	epidermal growth factor like 1	Rattus norvegicus	94-97
12223091-3	2002	Methyl-beta-cyclodextrin and some osmolytes, such as glycerol, sucrose, proline, glycine, and heparin, could effectively prevent the aggregation, implying an artificial chaperone role of those substances during fatty acid synthase unfolding.	Proline	72-79	fatty acid synthase	Gallus gallus	211-230
12124299-0	2002	Supramolecular properties of the proline-rich gamma-Zein N-terminal domain.	Proline	33-40	prolamin 50 kDa gamma zein	Zea mays	46-56
12153745-1	2002	OBJECTIVE: To test the physiological properties of human insulin in which the amino acids Thr (B27) and Pro (B28) are interchanged (PT insulin).	Proline	104-107	insulin	Homo sapiens	57-64
12144822-2	2002	A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated degradation of p53 protein in vivo.	Proline	69-76	tumor protein p53	Homo sapiens	25-28
12144822-2	2002	A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated degradation of p53 protein in vivo.	Proline	69-76	tumor protein p53	Homo sapiens	146-149
12144822-2	2002	A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated degradation of p53 protein in vivo.	Proline	78-81	tumor protein p53	Homo sapiens	25-28
12144822-2	2002	A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated degradation of p53 protein in vivo.	Proline	78-81	tumor protein p53	Homo sapiens	146-149
12144822-7	2002	The frequency of distribution of the three genotypes of p53 codon 72 in a subgroup of the HPV16/18-positive cervical cancer patients was Pro/Pro 0.18 and Arg/Arg 0.26, with the heterozygous Pro/Arg 0.56, differing significantly from the genotype frequency in the normal healthy women (chi(2) = 6.928, df = 2, P &lt; 0.05).	Proline	137-140	tumor protein p53	Homo sapiens	56-59
12144822-7	2002	The frequency of distribution of the three genotypes of p53 codon 72 in a subgroup of the HPV16/18-positive cervical cancer patients was Pro/Pro 0.18 and Arg/Arg 0.26, with the heterozygous Pro/Arg 0.56, differing significantly from the genotype frequency in the normal healthy women (chi(2) = 6.928, df = 2, P &lt; 0.05).	Proline	141-144	tumor protein p53	Homo sapiens	56-59
12112575-5	2002	The putative Xmegs protein contained 19 tandem repeats of 26 amino acid residues rich in proline as well as potential phosphorylation sites (i.e., serine and threonine residues).	Proline	89-96	meiotic meta-phase expressing gene in spermatogenesis L homeolog	Xenopus laevis	13-18
12177470-4	2002	A comparative analysis of all plant DXR sequences known to date predicted an N-terminal transit peptide for plastids, with a conserved cleavage site, and a conserved proline-rich region at the N terminus of the mature protein, which is not present in the prokaryotic DXR homologs.	Proline	166-173	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Arabidopsis thaliana	36-39
12100966-1	2002	Glyproline peptide family includes the simplest proline-containing linear peptides PG, GP, PGP, respective peptides with hydroxylated proline residues and (with some restriction) cyclic PG.	Proline	3-10	phosphoglycolate phosphatase	Homo sapiens	91-94
12177470-6	2002	The presence of the proline-rich region in the mature Arabidopsis DXR was confirmed by detection with a specific antibody.	Proline	20-27	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Arabidopsis thaliana	66-69
12115545-1	2002	p53 codon 72, which produces variant proteins with an arginine (Arg) or proline (Pro), has been reported to be associated with cancers of the lung, esophagus and cervix.	Proline	72-79	tumor protein p53	Homo sapiens	0-3
12000744-4	2002	Replacement of Leu(73) in the putative alpha-helical region in the prodomain with proline resulted in retention of ADAM12 in the ER and a complete lack of its processing.	Proline	82-89	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	Mus musculus	115-121
11994275-2	2002	Calpain binds to the N-terminal region of DNA ligase III, which contains an acidic proline, aspartate, serine, and threonine (PEST) domain frequently present in proteins cleaved by calpain.	Proline	83-90	DNA ligase 3	Homo sapiens	42-56
12115545-1	2002	p53 codon 72, which produces variant proteins with an arginine (Arg) or proline (Pro), has been reported to be associated with cancers of the lung, esophagus and cervix.	Proline	81-84	tumor protein p53	Homo sapiens	0-3
12091374-4	2002	Mean holoTCII concentration was significantly higher in those subjects homozygous for the proline form of TCII (PP) compared with those homozygous for the arginine form (RR) and heterozygotes (PR) (P &lt;or=.006).	Proline	90-97	transcobalamin 2	Homo sapiens	9-13
12747754-6	2002	The mutation, a C-to-T transition, changes a proline residue into a leucine at position 446 of the OS-9 protein.	Proline	45-52	OS9 endoplasmic reticulum lectin	Homo sapiens	99-103
12234674-5	2002	FOXD4a and FOXD4b are encoded by a 1319 and 1250 bp single exon coding for a winged helix DNA binding domain, an amino-terminal acidic region and a carboxy-terminal proline- and alanine-rich region which correspond to putative transcriptional regulatory motifs.	Proline	165-172	forkhead box D4	Homo sapiens	0-6
12150948-0	2002	Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23.	Proline	76-83	amyloid beta precursor protein	Rattus norvegicus	48-60
12234674-5	2002	FOXD4a and FOXD4b are encoded by a 1319 and 1250 bp single exon coding for a winged helix DNA binding domain, an amino-terminal acidic region and a carboxy-terminal proline- and alanine-rich region which correspond to putative transcriptional regulatory motifs.	Proline	165-172	forkhead box D4 like 4	Homo sapiens	11-17
12150948-3	2002	To identify amino acid residues that are important for the beta-sheet formation, a series of proline-substituted mutants of A beta 1-42 peptides at positions 19-26 was synthesized in a highly pure form and their aggregation ability and neurotoxicity on PC12 cells were investigated.	Proline	93-100	amyloid beta precursor protein	Rattus norvegicus	124-130
12150948-4	2002	All proline-substituted A beta 1-42 mutants except for 22P- and 23P-A beta 1-42 were hard to aggregate and showed weaker cytotoxicity than wild-type A beta 1-42, suggesting that the residues at positions 19-21 and 24-26 are important for the beta-sheet formation.	Proline	4-11	amyloid beta precursor protein	Rattus norvegicus	24-30
12084746-8	2002	RESULTS: There were significant differences in the distribution of the polymorphism between the control subjects and the POAG patients (p = 0.00782) The proline form of p53 gene codon 72 appears to be a significant risk factor in the development of POAG (odds ratio 2.389, 95% confidence interval: 1.14 to 5.01).	Proline	153-160	tumor protein p53	Homo sapiens	169-172
12150948-6	2002	Since proline has a propensity for beta-turn structure as a Pro-X corner, these data implicate that beta-turn formation at positions 22 and 23 plays a crucial role in the aggregation and neurotoxicity of A beta peptides.	Proline	6-13	amyloid beta precursor protein	Rattus norvegicus	204-210
12081494-4	2002	Using combinatorial fluorogenic substrate libraries, the P1-P4 substrate specificity of the cathepsin K variant, Tyr67Leu/Leu205Ala, was determined and compared with those of cathepsins K and L. The introduction of the double mutation into the S2 subsite of cathepsin K rendered the unique S2 binding preference of the protease for proline and leucine residues into a cathepsin L-like preference for bulky aromatic residues.	Proline	332-339	cathepsin K	Homo sapiens	92-103
12081494-7	2002	The loss of the ability to accept proline in the S2 binding pocket by the mutant protease completely abolished the collagenolytic activity of cathepsin K whereas its overall gelatinolytic activity remained unaffected.	Proline	34-41	cathepsin K	Homo sapiens	142-153
12081494-8	2002	These results indicate that Tyr67 and Leu205 play a key role in the binding of proline residues in the S2 pocket of cathepsin K and are required for its unique collagenase activity.	Proline	79-86	cathepsin K	Homo sapiens	116-127
12221910-1	2002	A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC.	Proline	197-200	tumor protein p53	Homo sapiens	34-37
12110441-5	2002	Mouse and human IL-11 also stimulated release of (3)H from [(3)H]-proline-labeled bones.	Proline	66-73	interleukin 11	Homo sapiens	16-21
12195866-6	2002	The underlying oxygen sensor is provided by a family of enzymes which oxidize specific proline residues in HIF alpha subunits.	Proline	87-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-116
12079283-3	2002	Mouse INSM1 was found to be 86% identical to human INSM1 and both proteins contain proline-rich regions and multiple zinc-finger DNA-binding motifs.	Proline	83-90	insulinoma-associated 1	Mus musculus	6-11
12079283-3	2002	Mouse INSM1 was found to be 86% identical to human INSM1 and both proteins contain proline-rich regions and multiple zinc-finger DNA-binding motifs.	Proline	83-90	INSM transcriptional repressor 1	Homo sapiens	51-56
12100158-3	2002	DNA sequencing revealed a novel missense mutation in the GPIX gene which replaced Leu (CTG) by Pro (CCG) at position 7 of the signal peptide.	Proline	95-98	glycoprotein IX platelet	Homo sapiens	57-61
12172962-5	2002	Sequence analysis of the mutant allele showed pso8-1 to contain a novel, hitherto undescribed T--&gt;C transition in nucleotide position 191, leading to a substitution by leucine of a highly conserved proline at position 64, Rad6-[P64L], which may have severe consequences for the tertiary structure (and hence binding to Rad18p) of the mutant protein.	Proline	201-208	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	46-50
12172962-5	2002	Sequence analysis of the mutant allele showed pso8-1 to contain a novel, hitherto undescribed T--&gt;C transition in nucleotide position 191, leading to a substitution by leucine of a highly conserved proline at position 64, Rad6-[P64L], which may have severe consequences for the tertiary structure (and hence binding to Rad18p) of the mutant protein.	Proline	201-208	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	225-229
12172962-5	2002	Sequence analysis of the mutant allele showed pso8-1 to contain a novel, hitherto undescribed T--&gt;C transition in nucleotide position 191, leading to a substitution by leucine of a highly conserved proline at position 64, Rad6-[P64L], which may have severe consequences for the tertiary structure (and hence binding to Rad18p) of the mutant protein.	Proline	201-208	E3 ubiquitin-protein ligase RAD18	Saccharomyces cerevisiae S288C	322-328
12072377-1	2002	Aortic carboxypeptidase-like protein (ACLP) is a 175-kDa protein that is expressed in vascular smooth muscle cells and contains a signal peptide sequence, a lysine- and proline-rich repeating motif, a discoidin-like domain with 35% identity to discoidin I, and a carboxypeptidase-like domain that is 39% identical with carboxypeptidase E.	Proline	169-176	AE binding protein 1	Mus musculus	0-36
12072377-1	2002	Aortic carboxypeptidase-like protein (ACLP) is a 175-kDa protein that is expressed in vascular smooth muscle cells and contains a signal peptide sequence, a lysine- and proline-rich repeating motif, a discoidin-like domain with 35% identity to discoidin I, and a carboxypeptidase-like domain that is 39% identical with carboxypeptidase E.	Proline	169-176	AE binding protein 1	Mus musculus	38-42
12221910-1	2002	A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC.	Proline	197-200	tumor protein p53	Homo sapiens	177-180
12221910-1	2002	A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC.	Proline	197-200	tumor protein p53	Homo sapiens	177-180
12136232-7	2002	In one family, congenital profound deafness without RP was associated with a C to G transversion in the alternatively spliced exon D, predicting an arginine to proline substitution at codon 608 in the proline-, serine- and threonine-rich region of harmonin.	Proline	160-167	USH1 protein network component harmonin	Mus musculus	248-256
12221910-1	2002	A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC.	Proline	197-200	tumor protein p53	Homo sapiens	177-180
12065470-0	2002	Localization within a proline-rich antigen (Ag2/PRA) of protective antigenicity against infection with Coccidioides immitis in mice.	Proline	22-29	anterior gradient 2	Mus musculus	44-47
12065470-0	2002	Localization within a proline-rich antigen (Ag2/PRA) of protective antigenicity against infection with Coccidioides immitis in mice.	Proline	22-29	S100 calcium binding protein A6 (calcyclin)	Mus musculus	48-51
12221910-6	2002	Among cases with CC the proportions of the p53 genotypes at codon 72 were 0.05 to proline homozygous, 0.5 to heterozygous, and 0.45 to arginine-homozygous.	Proline	82-89	tumor protein p53	Homo sapiens	43-46
12065470-1	2002	Subunits of a proline-rich coccidioidal antigen (Ag2/PRA) of Coccidioides immitis were analyzed by comparison as vaccines in mice.	Proline	14-21	anterior gradient 2	Mus musculus	49-52
12164929-1	2002	Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72.	Proline	231-238	tumor protein p53	Homo sapiens	16-19
12065470-1	2002	Subunits of a proline-rich coccidioidal antigen (Ag2/PRA) of Coccidioides immitis were analyzed by comparison as vaccines in mice.	Proline	14-21	S100 calcium binding protein A6 (calcyclin)	Mus musculus	53-56
12065493-1	2002	The vaccine efficacy of the gene sequence encoding the signal peptide of the antigen known as antigen 2 or proline-rich antigen (Ag2/PRA), an immunodominant antigen present in the cell wall of the fungal pathogen Coccidioides immitis, was investigated in a murine model of coccidioidomycosis.	Proline	107-114	anterior gradient 2	Mus musculus	129-132
12164929-1	2002	Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72.	Proline	231-238	tumor protein p53	Homo sapiens	142-145
12164929-1	2002	Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72.	Proline	231-238	tumor protein p53	Homo sapiens	142-145
12164929-1	2002	Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72.	Proline	231-238	tumor protein p53	Homo sapiens	142-145
12082049-3	2002	Genetic analysis revealed a new heterozygous mutation in the caveolin-3 (CAV-3) gene: a C--&gt;T transition at nucleotide position 83 in exon 1 leading to a substitution of a proline for a leucine at amino acid position 28 (P28L).	Proline	175-182	caveolin 3	Homo sapiens	61-71
12082049-3	2002	Genetic analysis revealed a new heterozygous mutation in the caveolin-3 (CAV-3) gene: a C--&gt;T transition at nucleotide position 83 in exon 1 leading to a substitution of a proline for a leucine at amino acid position 28 (P28L).	Proline	175-182	caveolin 3	Homo sapiens	73-78
12101279-2	2002	Purified DPP IV has been recognized to inactivate peptide hormones, neuropeptides, and some chemokines by cleavage behind a proline residue at the penultimate N-terminal amino acid position.	Proline	124-131	dipeptidyl peptidase 4	Homo sapiens	9-15
12134077-0	2002	Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization.	Proline	101-108	ENAH actin regulator	Homo sapiens	16-24
12052857-4	2002	Since one of the phosphorylation sites lies within the Cln2 PEST motif, a sequence rich in proline, aspartate or glutamate, serine, and threonine residues found in many unstable proteins, we fused various Cln2 C-terminal domains containing combinations of the PEST and the phosphoacceptor motifs to stable reporter proteins.	Proline	91-98	cyclin CLN2	Saccharomyces cerevisiae S288C	55-59
12052889-14	2002	However, the proline-rich MK2 N terminus provides a distinct role restricted to cell migration.	Proline	13-20	MAP kinase-activated protein kinase 2	Mus musculus	26-29
12052894-2	2002	Alignment of the HIC1 and HRG22 proteins from various species highlighted a perfectly conserved GLDLSKK/R motif highly related to the consensus CtBP interaction motif (PXDLSXK/R), except for the replacement of the virtually invariant proline by a glycine.	Proline	234-241	HIC ZBTB transcriptional repressor 1	Homo sapiens	17-21
12052894-2	2002	Alignment of the HIC1 and HRG22 proteins from various species highlighted a perfectly conserved GLDLSKK/R motif highly related to the consensus CtBP interaction motif (PXDLSXK/R), except for the replacement of the virtually invariant proline by a glycine.	Proline	234-241	HIC ZBTB transcriptional repressor 2	Homo sapiens	26-31
12134077-4	2002	The proline-rich region, the putative G-actin binding site, and the Ser/Thr phosphorylation of Ena/VASP proteins are all required for efficient Listeria motility.	Proline	4-11	vasodilator stimulated phosphoprotein	Homo sapiens	99-103
12127154-4	2002	Next to a frequent T > C single nucleotide polymorphism in exon 8, two novel mutations linked in exon 15 of the OTOF long splice form were identified comprising substitutions at positions 490 (Pro > Gln) and 515 (Ile > Thr), both located in the conserved Ca(2+) binding C2C domain of this peptide.	Proline	193-196	otoferlin	Homo sapiens	112-116
14993394-3	2002	Oxygen-dependent hydroxylation of conserved proline and asparagine residues in HIF-alpha are required for targeting HIF-alpha to proteasomes for destruction, and for inhibiting its capacity for CBP/p300-dependent transactivation, respectively.	Proline	44-51	CREB binding protein	Homo sapiens	194-202
11959855-7	2002	Molecular modeling indicates that the selective substrates adopt a linear conformation that extends along the entire catalytic pocket of MT1-MMP, whereas non-selective substrates are kinked at the conserved P(3) Pro residue.	Proline	210-215	matrix metallopeptidase 14	Homo sapiens	137-144
12110186-4	2002	We present strong evidence that ligand engagement of TCR-CD3 induces a conformational change that exposes a proline-rich sequence in CD3 epsilon and results in recruitment of the adaptor protein Nck.	Proline	108-115	NCK adaptor protein 1	Homo sapiens	195-198
12069594-1	2002	The structure of [Ala(31), Pro(32)]-NPY, a neuropeptide Y mutant with selectivity for the NPY Y(5)-receptor (Cabrele, C., Wieland, H. A., Stidsen, C., Beck-Sickinger, A. G., (2002) Biochemistry XX, XXXX-XXXX (companion paper)), has been characterized in the presence of the membrane mimetic dodecylphosphocholine (DPC) micelles using high-resolution NMR techniques.	Proline	27-30	neuropeptide Y	Homo sapiens	36-39
12069594-11	2002	However, signal reductions due to efficient electron, nuclear spin relaxation were much less pronounced for the surface-averted residues in [Ala(31), Pro(32)]-NPY when compared to wild-type DPC-bound NPY.	Proline	150-153	neuropeptide Y	Homo sapiens	159-162
12069594-13	2002	The postulation of a different membrane binding mode of [Ala(31), Pro(32)]-NPY is further supported by the faster H/D exchange at the C-terminal amide protons.	Proline	66-69	neuropeptide Y	Homo sapiens	75-78
11925437-0	2002	Role of the proline-rich domain of dynamin-2 and its interactions with Src homology 3 domains during endocytosis of the AT1 angiotensin receptor.	Proline	12-19	dynamin-2	Cricetulus griseus	35-44
11943775-6	2002	The proline 180 and glycine 181 residues in the extracellular domain of CD147 were critical for signaling and chemotactic activities mediated by CD147.	Proline	4-11	basigin (Ok blood group)	Homo sapiens	72-77
11943775-6	2002	The proline 180 and glycine 181 residues in the extracellular domain of CD147 were critical for signaling and chemotactic activities mediated by CD147.	Proline	4-11	basigin (Ok blood group)	Homo sapiens	145-150
11943772-0	2002	Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling.	Proline	36-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	15-18
11943772-0	2002	Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling.	Proline	36-43	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	23-26
11943772-2	2002	Molecular cloning of GPVI has revealed the presence of a proline-rich domain in the sequence of GPVI cytoplasmic tail which has the consensus for interaction with the Src homology 3 (SH3) domains of Fyn and Lyn.	Proline	57-64	glycoprotein VI platelet	Homo sapiens	21-25
11943772-2	2002	Molecular cloning of GPVI has revealed the presence of a proline-rich domain in the sequence of GPVI cytoplasmic tail which has the consensus for interaction with the Src homology 3 (SH3) domains of Fyn and Lyn.	Proline	57-64	glycoprotein VI platelet	Homo sapiens	96-100
11959859-4	2002	Both mPAT1 and mPAT2 induced a pH-dependent electrogenic transport activity for small amino acids (glycine, alanine, and proline) that is altered by membrane potential.	Proline	121-128	solute carrier family 36 (proton/amino acid symporter), member 1	Mus musculus	5-10
11959859-4	2002	Both mPAT1 and mPAT2 induced a pH-dependent electrogenic transport activity for small amino acids (glycine, alanine, and proline) that is altered by membrane potential.	Proline	121-128	solute carrier family 36 (proton/amino acid symporter), member 2	Mus musculus	15-20
12056893-4	2002	The single proline to alanine mutation in the S/TPKK motifs either singly or in combination resulted in only a 20% decrease in the DNA-condensation property of histone H1.	Proline	11-18	H1.0 linker histone	Rattus norvegicus	160-170
12049630-0	2002	Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton.	Proline	16-23	trophinin associated protein	Homo sapiens	6-12
11943772-2	2002	Molecular cloning of GPVI has revealed the presence of a proline-rich domain in the sequence of GPVI cytoplasmic tail which has the consensus for interaction with the Src homology 3 (SH3) domains of Fyn and Lyn.	Proline	57-64	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	167-170
11943772-2	2002	Molecular cloning of GPVI has revealed the presence of a proline-rich domain in the sequence of GPVI cytoplasmic tail which has the consensus for interaction with the Src homology 3 (SH3) domains of Fyn and Lyn.	Proline	57-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	199-202
11925437-3	2002	Dynamin-2 molecules with mutant pleckstrin homology domains or deleted proline-rich domains (PRD) exerted dominant negative inhibition on the endocytosis of radiolabeled angiotensin II.	Proline	71-78	dynamin-2	Cricetulus griseus	0-9
11943772-2	2002	Molecular cloning of GPVI has revealed the presence of a proline-rich domain in the sequence of GPVI cytoplasmic tail which has the consensus for interaction with the Src homology 3 (SH3) domains of Fyn and Lyn.	Proline	57-64	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	207-210
12037672-7	2002	This region contains at least three proline-directed serines (sp), S795, S807 and S811, which have been reported to be phosphorylated in vivo and which could be targeted by the cdk9 complex.	Proline	36-43	cyclin dependent kinase 9	Homo sapiens	177-181
11943772-3	2002	A series of in vitro experiments demonstrated the ability of the SH3 domains of both Src kinases to bind the proline-rich domain of GPVI.	Proline	109-116	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	85-88
11943772-3	2002	A series of in vitro experiments demonstrated the ability of the SH3 domains of both Src kinases to bind the proline-rich domain of GPVI.	Proline	109-116	glycoprotein VI platelet	Homo sapiens	132-136
11943772-4	2002	Furthermore, depletion of the proline-rich domain in GPVI (Pro(-)-GPVI) prevented binding of Fyn and Lyn and markedly reduced phosphorylation of FcR gamma-chain in transiently transfected COS-7 cells, but did not affect the association of the gamma-chain with GPVI.	Proline	30-37	glycoprotein VI platelet	Homo sapiens	53-57
11943772-4	2002	Furthermore, depletion of the proline-rich domain in GPVI (Pro(-)-GPVI) prevented binding of Fyn and Lyn and markedly reduced phosphorylation of FcR gamma-chain in transiently transfected COS-7 cells, but did not affect the association of the gamma-chain with GPVI.	Proline	30-37	glycoprotein VI platelet	Homo sapiens	59-70
11943772-4	2002	Furthermore, depletion of the proline-rich domain in GPVI (Pro(-)-GPVI) prevented binding of Fyn and Lyn and markedly reduced phosphorylation of FcR gamma-chain in transiently transfected COS-7 cells, but did not affect the association of the gamma-chain with GPVI.	Proline	30-37	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	93-96
11943772-4	2002	Furthermore, depletion of the proline-rich domain in GPVI (Pro(-)-GPVI) prevented binding of Fyn and Lyn and markedly reduced phosphorylation of FcR gamma-chain in transiently transfected COS-7 cells, but did not affect the association of the gamma-chain with GPVI.	Proline	30-37	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	101-104
11943772-4	2002	Furthermore, depletion of the proline-rich domain in GPVI (Pro(-)-GPVI) prevented binding of Fyn and Lyn and markedly reduced phosphorylation of FcR gamma-chain in transiently transfected COS-7 cells, but did not affect the association of the gamma-chain with GPVI.	Proline	30-37	glycoprotein VI platelet	Homo sapiens	66-70
11943772-7	2002	These findings demonstrate that the proline-rich domain of GPVI mediates the association with Fyn/Lyn via their SH3 domain and that this interaction initiates activation signals through GPVI.	Proline	36-43	glycoprotein VI platelet	Homo sapiens	59-63
11943772-7	2002	These findings demonstrate that the proline-rich domain of GPVI mediates the association with Fyn/Lyn via their SH3 domain and that this interaction initiates activation signals through GPVI.	Proline	36-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-97
11943772-7	2002	These findings demonstrate that the proline-rich domain of GPVI mediates the association with Fyn/Lyn via their SH3 domain and that this interaction initiates activation signals through GPVI.	Proline	36-43	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	98-101
12119116-9	2002	Two sequence differences that may relate to the instability are that trout LPL lacks the disulfide bridge in the C-terminal domain and lacks Pro(258).	Proline	141-144	lipoprotein lipase	Homo sapiens	75-78
12060782-5	2002	This single nucleotide polymorphism results in a missense mutation (385C-->A) that converts a conserved proline residue to threonine (Pro129-->Thr), producing a FAAH variant that displays normal catalytic properties but an enhanced sensitivity to proteolytic degradation.	Proline	104-111	fatty acid amide hydrolase	Homo sapiens	161-165
12049789-4	2002	To investigate the interaction, an NMR study was carried out on the binding of a representative polyphenol, penta-O-galloyl-D-glucopyranose, to a nonapeptide hormone, bradykinin (BDK), where proline accounts for 30% of residues.	Proline	191-198	kininogen 1	Homo sapiens	167-177
12004076-2	2002	pVHL binds to HIF only when a conserved proline in HIF is hydroxylated, a modification that is oxygen-dependent.	Proline	40-47	von Hippel-Lindau tumor suppressor	Homo sapiens	0-4
12102507-8	2002	[14C]Proline was transported from the scutellum to other parts of the seedling and reached the highest concentration in the root tip.	Proline	5-12	NAC domain-containing protein 74	Zea mays	129-132
12102507-9	2002	Less [14C]proline was transported at low water potential but because of the lower rate of protein synthesis and oxidation, more accumulated as proline in the root tip.	Proline	10-17	NAC domain-containing protein 74	Zea mays	163-166
12102507-9	2002	Less [14C]proline was transported at low water potential but because of the lower rate of protein synthesis and oxidation, more accumulated as proline in the root tip.	Proline	143-150	NAC domain-containing protein 74	Zea mays	163-166
12067826-3	2002	We report here a family with hypocalcemia in whom a heterozygous missense mutation in exon 4 was demonstrated, predicting a proline to leucine substitution (P221L) in the extracellular part of the Ca-R.	Proline	124-131	calcium sensing receptor	Homo sapiens	197-201
12023880-9	2002	In contrast, both the C-terminal proline-rich region and the tandem tyrosine residues present in the N-terminal region are required for the activation of Src family kinases.	Proline	33-40	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	154-157
12047385-8	2002	The deduced amino-acid sequences of human and bovine MUC15 demonstrated structural hallmarks characteristic for other membrane-bound mucins, such as a serine, threonine, and proline-rich extracellular region with several potential glycosylation sites, a putative transmembrane domain, and a short cytoplasmic C-terminal.	Proline	174-181	mucin 15, cell surface associated	Bos taurus	53-58
12051677-3	2002	Among isomerases and enzymes in general, 4-OT is unusual for two reasons: it has one of the smallest known monomer sizes (62 amino acids) and the amino-terminal proline functions as the catalytic base.	Proline	161-168	4-oxalocrotonate tautomerase	Escherichia coli	41-45
12391723-1	2002	A TG dinucleotide repeat was identified in intron 6 of the human proteasome core particle PROS-27K (IOTA, PSMA6) gene.	Proline	90-94	proteasome 20S subunit alpha 6	Homo sapiens	106-111
12021389-0	2002	ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-to-blood efflux transport for L-proline.	Proline	119-128	solute carrier family 38 member 2	Homo sapiens	0-4
11997510-5	2002	Glutathione S-transferase pull-down experiments demonstrate that the Mona and Gab3 interaction utilizes the carboxy-terminal SH3 domain of Mona and the atypical proline-rich domain of Gab3.	Proline	161-168	GRB2-related adaptor protein 2	Mus musculus	69-73
12031624-3	2002	The second patient carried a G-to-C mutation, changing GCT (alanine) to CCT (proline) at codon 686 (A686P) in exon 17.	Proline	77-84	CCT	Homo sapiens	72-75
11997510-5	2002	Glutathione S-transferase pull-down experiments demonstrate that the Mona and Gab3 interaction utilizes the carboxy-terminal SH3 domain of Mona and the atypical proline-rich domain of Gab3.	Proline	161-168	growth factor receptor bound protein 2-associated protein 3	Mus musculus	78-82
11997510-5	2002	Glutathione S-transferase pull-down experiments demonstrate that the Mona and Gab3 interaction utilizes the carboxy-terminal SH3 domain of Mona and the atypical proline-rich domain of Gab3.	Proline	161-168	GRB2-related adaptor protein 2	Mus musculus	139-143
11997510-5	2002	Glutathione S-transferase pull-down experiments demonstrate that the Mona and Gab3 interaction utilizes the carboxy-terminal SH3 domain of Mona and the atypical proline-rich domain of Gab3.	Proline	161-168	growth factor receptor bound protein 2-associated protein 3	Mus musculus	184-188
12058076-3	2002	Glutathione S-transferase pull-down and coimmunoprecipitation assays showed the binding of ASAP1 to FAK is mediated by an interaction between the C-terminal SH3 domain of ASAP1 with the second proline-rich motif in the C-terminal region of FAK.	Proline	193-200	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Rattus norvegicus	91-96
12058076-3	2002	Glutathione S-transferase pull-down and coimmunoprecipitation assays showed the binding of ASAP1 to FAK is mediated by an interaction between the C-terminal SH3 domain of ASAP1 with the second proline-rich motif in the C-terminal region of FAK.	Proline	193-200	protein tyrosine kinase 2	Rattus norvegicus	100-103
12058076-3	2002	Glutathione S-transferase pull-down and coimmunoprecipitation assays showed the binding of ASAP1 to FAK is mediated by an interaction between the C-terminal SH3 domain of ASAP1 with the second proline-rich motif in the C-terminal region of FAK.	Proline	193-200	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Rattus norvegicus	171-176
12126740-3	2002	In human osteosarcoma cell-line (SaOS-2), oxytocin 100 pmol/l increased cell proliferation (measured by [3H]thymidine incorporation and a commercially available kit) and protein synthesis ([3H]proline incorporation) (P&lt;0.05).	Proline	193-200	oxytocin/neurophysin I prepropeptide	Homo sapiens	42-50
12095687-8	2002	We find that most paired-related homeodomain proteins, including mouse and human Mix, contain a proline-rich region within their amino termini which may interact with other proteins.	Proline	96-103	Mix paired-like homeobox	Homo sapiens	81-84
12057191-3	2002	We have determined the 1.6 A crystal structure of a C-terminal fragment of human Groucho/TLE1, comprising part of the Ser/Pro-rich region and a seven-bladed beta propeller WD40 repeat domain, implicated in protein-protein interactions.	Proline	122-125	TLE family member 1, transcriptional corepressor	Homo sapiens	89-93
11914378-2	2002	Thr(229) phosphorylation requires prior phosphorylation of the Ser/Thr-Pro sites in the autoinhibitory domain and Thr(389) in the linker domain, consistent with PDK1 more effectively catalyzing Thr(229) phosphorylation in a variant harboring acidic residues in these positions (S6K1-E389D(3)E).	Proline	71-74	pyruvate dehydrogenase kinase 1	Homo sapiens	161-165
12032306-6	2002	The introduction of a proline in the first turn of an alpha-helix of this 37-mer obliterates transfection activity, suggesting that the integrity of the alpha-helical structure of the N-terminal region of histone H2A is related to its transfection activity.	Proline	22-29	H2A clustered histone 18	Homo sapiens	213-216
12009900-8	2002	Examination of various compounds with Ava in positions 9,10 and/or 14,15 revealed that the Leu(9)-Gly(10) and Arg(14)-Pro(15) segments of the disulfide ring are the principal structural elements determining hMCH-1R selectivity and ability to act as a hMCH-1R antagonist.	Proline	118-121	melanin concentrating hormone receptor 1	Homo sapiens	207-214
12054669-5	2002	Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK.	Proline	24-27	DnaJ	Escherichia coli	84-88
12054669-5	2002	Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK.	Proline	24-27	DnaJ	Escherichia coli	117-121
12054669-5	2002	Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK.	Proline	67-70	DnaJ	Escherichia coli	84-88
12054669-5	2002	Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK.	Proline	67-70	DnaJ	Escherichia coli	117-121
12009900-3	2002	In this study, analogues of Ac-Arg(6)-cyclo(S-S)(Cys(7)-Met(8)-Leu(9)-Gly(10)-Arg(11)-Val(12)-Tyr(13)-Arg(14)-Pro(15)-Cys(16))-NH(2), a high affinity but nonselective agonist at hMCH-1R and hMCH-2R, were prepared and tested in binding and functional assays on cells expressing these receptors.	Proline	110-113	CD7 molecule	Homo sapiens	63-68
12009900-8	2002	Examination of various compounds with Ava in positions 9,10 and/or 14,15 revealed that the Leu(9)-Gly(10) and Arg(14)-Pro(15) segments of the disulfide ring are the principal structural elements determining hMCH-1R selectivity and ability to act as a hMCH-1R antagonist.	Proline	118-121	melanin concentrating hormone receptor 1	Homo sapiens	251-258
12062808-4	2002	The mouse Wave1 complementary DNA encodes a predicted 559 amino acid protein, with a SCAR homology domain, a basic domain, a proline-rich region, a WASP homology domain and an acidic domain conserved in the orthologous proteins.	Proline	125-132	WASP family, member 1	Mus musculus	10-15
12083514-6	2002	The study shows that the packing interactions between the alpha2 and alpha1 helices in HSF_KL are responsible for the stabilization of the conserved kink, whether a proline residue that divides the helix into segments is present or not.	Proline	165-172	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	58-75
12054806-0	2002	Crystal structure of the Homer 1 family conserved region reveals the interaction between the EVH1 domain and own proline-rich motif.	Proline	113-120	homer scaffold protein 1	Homo sapiens	25-32
12051754-5	2002	Bufuralol 1(")-hydroxylase activity in microsomes of yeast expressing CYP2D6.10 was rapidly decreased by heat treatment, supporting the idea that the thermal stability of the enzyme was reduced by amino acid replacement from Pro (CYP2D6.1) to Ser (CYP2D6.10).	Proline	225-228	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	70-76
12023040-1	2002	EVH1 (enabled VASP (vasodilator-stimulated protein) homology 1)/WH1 (WASP (Wiskott-Aldrich syndrome protein) homology 1) domains, present in Ena VASP and WASP, are protein interaction modules specialised in binding proline-rich ligands.	Proline	215-222	vasodilator stimulated phosphoprotein	Homo sapiens	14-18
12023040-1	2002	EVH1 (enabled VASP (vasodilator-stimulated protein) homology 1)/WH1 (WASP (Wiskott-Aldrich syndrome protein) homology 1) domains, present in Ena VASP and WASP, are protein interaction modules specialised in binding proline-rich ligands.	Proline	215-222	vasodilator stimulated phosphoprotein	Homo sapiens	20-50
12023040-1	2002	EVH1 (enabled VASP (vasodilator-stimulated protein) homology 1)/WH1 (WASP (Wiskott-Aldrich syndrome protein) homology 1) domains, present in Ena VASP and WASP, are protein interaction modules specialised in binding proline-rich ligands.	Proline	215-222	WASP actin nucleation promoting factor	Homo sapiens	69-73
12023040-1	2002	EVH1 (enabled VASP (vasodilator-stimulated protein) homology 1)/WH1 (WASP (Wiskott-Aldrich syndrome protein) homology 1) domains, present in Ena VASP and WASP, are protein interaction modules specialised in binding proline-rich ligands.	Proline	215-222	WASP actin nucleation promoting factor	Homo sapiens	75-107
12023040-1	2002	EVH1 (enabled VASP (vasodilator-stimulated protein) homology 1)/WH1 (WASP (Wiskott-Aldrich syndrome protein) homology 1) domains, present in Ena VASP and WASP, are protein interaction modules specialised in binding proline-rich ligands.	Proline	215-222	vasodilator stimulated phosphoprotein	Homo sapiens	145-149
12023040-1	2002	EVH1 (enabled VASP (vasodilator-stimulated protein) homology 1)/WH1 (WASP (Wiskott-Aldrich syndrome protein) homology 1) domains, present in Ena VASP and WASP, are protein interaction modules specialised in binding proline-rich ligands.	Proline	215-222	WASP actin nucleation promoting factor	Homo sapiens	154-158
12023040-3	2002	The SMIF EVH1/WH1 domain interacts with the proline-rich Smad4 activation domain, leading to translocation of so-formed complex to the nucleus where SMIF possesses strong intrinsic TGFbeta-inducible transcriptional activity.	Proline	44-51	decapping mRNA 1A	Homo sapiens	4-8
12023040-3	2002	The SMIF EVH1/WH1 domain interacts with the proline-rich Smad4 activation domain, leading to translocation of so-formed complex to the nucleus where SMIF possesses strong intrinsic TGFbeta-inducible transcriptional activity.	Proline	44-51	decapping mRNA 1A	Homo sapiens	149-153
12023040-3	2002	The SMIF EVH1/WH1 domain interacts with the proline-rich Smad4 activation domain, leading to translocation of so-formed complex to the nucleus where SMIF possesses strong intrinsic TGFbeta-inducible transcriptional activity.	Proline	44-51	transforming growth factor beta 1	Homo sapiens	181-188
11859090-6	2002	Among the mutant viruses encoding Env proteins in which residues Val-832 and Val-833 were individually substituted by nonconserved amino acids Ala, Ser, or Pro, which were expected to disrupt the alpha-helical structure in the increasingly severe manner of Pro &gt; Ser &gt; Ala, only the 833P mutant exhibited significantly reduced steady-state Env expression.	Proline	156-159	endogenous retrovirus group K member 20	Homo sapiens	34-37
11844803-2	2002	EKLF/KLF-1 is a 358-amino acid nuclear protein with an amino-terminal proline-rich domain and a carboxyl-terminal DNA binding domain.	Proline	70-77	Kruppel like factor 1	Homo sapiens	0-4
11844803-2	2002	EKLF/KLF-1 is a 358-amino acid nuclear protein with an amino-terminal proline-rich domain and a carboxyl-terminal DNA binding domain.	Proline	70-77	Kruppel like factor 1	Homo sapiens	5-10
11854271-3	2002	ZIN contains four RING-like zinc finger domains at the middle and a proline-rich domain at the C terminus.	Proline	68-75	ring finger protein 216	Homo sapiens	0-3
11859090-6	2002	Among the mutant viruses encoding Env proteins in which residues Val-832 and Val-833 were individually substituted by nonconserved amino acids Ala, Ser, or Pro, which were expected to disrupt the alpha-helical structure in the increasingly severe manner of Pro &gt; Ser &gt; Ala, only the 833P mutant exhibited significantly reduced steady-state Env expression.	Proline	156-159	endogenous retrovirus group K member 20	Homo sapiens	346-349
11859090-6	2002	Among the mutant viruses encoding Env proteins in which residues Val-832 and Val-833 were individually substituted by nonconserved amino acids Ala, Ser, or Pro, which were expected to disrupt the alpha-helical structure in the increasingly severe manner of Pro &gt; Ser &gt; Ala, only the 833P mutant exhibited significantly reduced steady-state Env expression.	Proline	257-260	endogenous retrovirus group K member 20	Homo sapiens	34-37
12168882-5	2002	The amino acid residue at this position is either arginine (p53-Arg) or proline (p53-Pro).	Proline	72-79	tumor protein p53	Homo sapiens	81-84
12000728-1	2002	Arpp, a protein containing an ankyrin repeat domain, PEST sequence, and proline-rich region, is a novel ankyrin-repeated protein highly homologous to Carp, which is proposed to be the putative genetic marker for cardiac hypertrophy.	Proline	72-79	ankyrin repeat domain 2 (stretch responsive muscle)	Mus musculus	0-4
12031628-2	2002	beta-spirals using canonical proline-nucleated beta-turns in diverse proteins allow for vital functions including structural (mucin and amelogenin), respiratory (elastin), muscular (titin), and that of genetic expression (RNA polymerase II).	Proline	29-36	LOC100508689	Homo sapiens	126-131
12031628-2	2002	beta-spirals using canonical proline-nucleated beta-turns in diverse proteins allow for vital functions including structural (mucin and amelogenin), respiratory (elastin), muscular (titin), and that of genetic expression (RNA polymerase II).	Proline	29-36	elastin	Homo sapiens	162-169
12031628-2	2002	beta-spirals using canonical proline-nucleated beta-turns in diverse proteins allow for vital functions including structural (mucin and amelogenin), respiratory (elastin), muscular (titin), and that of genetic expression (RNA polymerase II).	Proline	29-36	titin	Homo sapiens	182-187
11964172-2	2002	In order to study the role of Grb2 in blood platelet responses, we used a peptide containing two proline-rich sequences derived from Sos (peptidimer), which binds to Grb2-Src homology 3 domain (SH3) with a high affinity, and hence inhibits Grb2-SH3-mediated protein interactions.	Proline	97-104	growth factor receptor bound protein 2	Homo sapiens	166-170
11964172-2	2002	In order to study the role of Grb2 in blood platelet responses, we used a peptide containing two proline-rich sequences derived from Sos (peptidimer), which binds to Grb2-Src homology 3 domain (SH3) with a high affinity, and hence inhibits Grb2-SH3-mediated protein interactions.	Proline	97-104	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	171-174
11964172-2	2002	In order to study the role of Grb2 in blood platelet responses, we used a peptide containing two proline-rich sequences derived from Sos (peptidimer), which binds to Grb2-Src homology 3 domain (SH3) with a high affinity, and hence inhibits Grb2-SH3-mediated protein interactions.	Proline	97-104	growth factor receptor bound protein 2	Homo sapiens	166-170
11961139-0	2002	The critical role of transmembrane prolines in human prostacyclin receptor activation.	Proline	35-43	prostaglandin I2 receptor	Homo sapiens	53-74
11964172-5	2002	Grb2-SH3 domains formed an association with the proline-rich sequences of Sos and Cbl in both resting and activated platelets, since the peptidimer abolished these associations.	Proline	48-55	growth factor receptor bound protein 2	Homo sapiens	0-4
11964172-5	2002	Grb2-SH3 domains formed an association with the proline-rich sequences of Sos and Cbl in both resting and activated platelets, since the peptidimer abolished these associations.	Proline	48-55	Cbl proto-oncogene	Homo sapiens	82-85
11964291-0	2002	Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure.	Proline	16-23	membrane-spanning 4-domains, subfamily A, member 1	Mus musculus	72-76
11932398-1	2002	We describe the results of a study by electron microscopy and image processing of Gag protein shells-immature capsids--of Mason-Pfizer monkey virus assembled in Escherichia coli from two truncated forms of the Gag precursor: Deltap4Gag, in which the C-terminal p4Gag was deleted, and Pro(-)CA.NC, in which the N-terminal peptides and proline 1 of the CA domain were deleted.	Proline	334-341	Pr78	Mason-Pfizer monkey virus	82-85
11964291-4	2002	Mutation of alanine and proline at positions 170 and 172 (AxP) (single-letter amino acid codes; x indicates the identical amino acid at the same position in the murine and human CD20 sequences) in human CD20 abrogated the binding of all CD20 mAbs tested.	Proline	24-31	keratin 20	Homo sapiens	178-182
11964291-4	2002	Mutation of alanine and proline at positions 170 and 172 (AxP) (single-letter amino acid codes; x indicates the identical amino acid at the same position in the murine and human CD20 sequences) in human CD20 abrogated the binding of all CD20 mAbs tested.	Proline	24-31	keratin 20	Homo sapiens	203-207
11964291-4	2002	Mutation of alanine and proline at positions 170 and 172 (AxP) (single-letter amino acid codes; x indicates the identical amino acid at the same position in the murine and human CD20 sequences) in human CD20 abrogated the binding of all CD20 mAbs tested.	Proline	24-31	keratin 20	Homo sapiens	203-207
12006537-1	2002	PURPOSE: It is known that a common p53 polymorphism, encodingeither proline (Pro) or arginine (Arg) at residue 72, produces marked change in the structure of p53.	Proline	68-75	tumor protein p53	Homo sapiens	35-38
12006537-1	2002	PURPOSE: It is known that a common p53 polymorphism, encodingeither proline (Pro) or arginine (Arg) at residue 72, produces marked change in the structure of p53.	Proline	68-75	tumor protein p53	Homo sapiens	158-161
12006537-1	2002	PURPOSE: It is known that a common p53 polymorphism, encodingeither proline (Pro) or arginine (Arg) at residue 72, produces marked change in the structure of p53.	Proline	77-80	tumor protein p53	Homo sapiens	35-38
12006537-1	2002	PURPOSE: It is known that a common p53 polymorphism, encodingeither proline (Pro) or arginine (Arg) at residue 72, produces marked change in the structure of p53.	Proline	77-80	tumor protein p53	Homo sapiens	158-161
12006537-7	2002	RESULTS: There was a bias to mutate and express the Arg allele in the p53 -mutated TCCs arising in individuals with heterozygosity (Pro/Arg).	Proline	132-135	tumor protein p53	Homo sapiens	70-73
11956592-4	2002	WRCH2 gene, consisting of at least 3 exons, encoded a 236-amino-acid protein with proline-rich domain and GTPase domain.	Proline	82-89	ras homolog family member V	Homo sapiens	0-5
11970986-9	2002	Interestingly, both the amino-terminal pleckstrin homology and phosphotyrosine binding domains and the carboxyl-terminal proline/tyrosine-rich region of p62(dok) can mediate inhibition, suggesting activation of parallel downstream signaling pathways that converge at extracellular signal-regulated kinase 1/2 activation.	Proline	121-128	nucleoporin 62	Mus musculus	153-156
11940662-1	2002	The sperm mitochondria-associated cysteine-rich protein (SMCP) is a cysteine- and proline-rich structural protein that is closely associated with the keratinous capsules of sperm mitochondria in the mitochondrial sheath surrounding the outer dense fibers and axoneme.	Proline	82-89	sperm mitochondria-associated cysteine-rich protein	Mus musculus	4-55
11940662-1	2002	The sperm mitochondria-associated cysteine-rich protein (SMCP) is a cysteine- and proline-rich structural protein that is closely associated with the keratinous capsules of sperm mitochondria in the mitochondrial sheath surrounding the outer dense fibers and axoneme.	Proline	82-89	sperm mitochondria-associated cysteine-rich protein	Mus musculus	57-61
11988841-4	2002	Pin1 and its homologues are known to target the proline residue carboxyl terminal to the phosphorylated threonine or serine residue of mitotic phosphoproteins, such as Bcl2.	Proline	48-55	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
11988841-4	2002	Pin1 and its homologues are known to target the proline residue carboxyl terminal to the phosphorylated threonine or serine residue of mitotic phosphoproteins, such as Bcl2.	Proline	48-55	BCL2 apoptosis regulator	Homo sapiens	168-172
11927911-5	2002	Expression of pTalpha mutants in transgenic mice, retrovirally transduced T cell precursors and cell lines showed that the pTalpha cytoplasmic tail, in particular the proline-rich domain, plays a crucial role in pre-TCR signaling and T cell development.	Proline	167-174	pre T cell antigen receptor alpha	Mus musculus	14-21
11927911-5	2002	Expression of pTalpha mutants in transgenic mice, retrovirally transduced T cell precursors and cell lines showed that the pTalpha cytoplasmic tail, in particular the proline-rich domain, plays a crucial role in pre-TCR signaling and T cell development.	Proline	167-174	pre T cell antigen receptor alpha	Mus musculus	123-130
11938353-3	2002	Here we describe a Pro residue in the center of the third transmembrane helix of the cystic fibrosis transmembrane conductance regulator that promotes folding by a distinct mechanism: disfavoring the formation of a misfolded structure.	Proline	19-22	CF transmembrane conductance regulator	Homo sapiens	85-136
12582622-2	2002	The SbPRP protein is a putative bimodular protein of 126 amino acids with a proline-rich domain and a hydrophobic cysteine-rich domain plus a signal peptide at the N terminal.	Proline	76-83	proline-rich protein	Glycine max	4-9
12011348-9	2002	The Arabidopsis homologue has been reported to encode a delta1-pyrroline-5-carboxylate dehydrogenase that is involved in the catabolism of proline to glutamate.	Proline	139-146	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	56-100
12138250-10	2002	Four T peptides, organized as amphiphilic alpha helices, can assemble around proline-rich motifs of ColQ or PRiMA.	Proline	77-84	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	100-104
12138250-10	2002	Four T peptides, organized as amphiphilic alpha helices, can assemble around proline-rich motifs of ColQ or PRiMA.	Proline	77-84	proline rich membrane anchor 1	Homo sapiens	108-113
11969422-7	2002	A proline residue immediately follows 7 of the 11 unambiguously identified phosphorylation sites, suggesting that MLK3 may be a target of proline-directed kinases.	Proline	2-9	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	114-118
11827972-6	2002	MICAL has a calponin homology domain, a LIM domain, a putative leucine zipper motif, and a proline-rich PPKPP sequence.	Proline	91-98	microtubule associated monooxygenase, calponin and LIM domain containing 1	Homo sapiens	0-5
11815627-10	2002	An alignment of the ACE2 peptide substrates reveals a consensus sequence of: Pro-X((1-3 residues))-Pro-Hydrophobic, where hydrolysis occurs between proline and the hydrophobic amino acid.	Proline	77-80	angiotensin converting enzyme 2	Homo sapiens	20-24
12062410-2	2002	The full-length mouse WARP cDNA is 2.3 kb in size and predicts a protein of 415 amino acids which contains a signal sequence, a VA-like domain, two fibronectin type III-like repeats, and a short proline- and arginine-rich segment.	Proline	195-202	von Willebrand factor A domain containing 1	Mus musculus	22-26
11815627-10	2002	An alignment of the ACE2 peptide substrates reveals a consensus sequence of: Pro-X((1-3 residues))-Pro-Hydrophobic, where hydrolysis occurs between proline and the hydrophobic amino acid.	Proline	148-155	angiotensin converting enzyme 2	Homo sapiens	20-24
11955060-3	2002	We investigated the interaction of proline-rich Tip peptides with the LckSH3 domain starting with the structural characterization of the unbound interaction partners.	Proline	35-42	TOR signaling pathway regulator	Homo sapiens	48-51
11877742-2	2002	Bruton tyrosine kinase (Btk) of the Tec family contains in the Tec homology (TH) domain a proline-rich region (PRR) capable of interacting with several SH3 domains.	Proline	90-97	Bruton tyrosine kinase	Homo sapiens	0-22
11877742-2	2002	Bruton tyrosine kinase (Btk) of the Tec family contains in the Tec homology (TH) domain a proline-rich region (PRR) capable of interacting with several SH3 domains.	Proline	90-97	Bruton tyrosine kinase	Homo sapiens	24-27
11929983-4	2002	We show here, using NMR exchange spectroscopy, that CypA does not only bind to CA(N) but also catalyzes efficiently the cis/trans isomerization of the Gly-89-Pro-90 peptide bond.	Proline	158-161	peptidylprolyl isomerase A	Homo sapiens	52-56
11812785-5	2002	DIP1/2 is a novel GTPase-activating protein containing a Ras GTPase-activating protein homology domain (N terminus) and two other unique domains (i.e. 10 proline repeats and leucine zipper).	Proline	154-161	DAB2 interacting protein	Homo sapiens	0-6
11931628-3	2002	This model predicts that the amide backbone of Cys(5)-Cys(6)-Glu(7)-Leu(8), the beta carbon atoms of Cys(5)-Cys(6), and the side chains of Pro(12), Ala(13), and Ala(15) comprise the primary interactions of GC-C agonists with the receptor surface.	Proline	139-142	guanylate cyclase 2C	Homo sapiens	206-210
11922623-7	2002	In the pro-BACE model there is no salt bridge, and the corresponding residue-a proline-does not interact at all with the catalytic residues.	Proline	79-86	beta-secretase 1	Homo sapiens	11-15
11812777-1	2002	The FILAMENTOUS FLOWER protein has a zinc finger domain, hydrophobic region, proline-rich region, and a HMG box-like domain.	Proline	77-84	Plant-specific transcription factor YABBY family protein	Arabidopsis thaliana	4-22
11868160-8	2002	This insertion mutation, which segregates in a dominant manner over four generations, introduces a frameshift and creates a premature stop codon, abolishing four functionally important proline-rich SH3 binding domains normally present in the carboxyl-terminal region of the SOS1 protein.	Proline	185-192	SOS Ras/Rac guanine nucleotide exchange factor 1	Mus musculus	274-278
11934838-2	2002	The first proline-rich region of PAK that binds to an SH3 domain from the adapter protein NCK was responsible for these dominant-negative effects.	Proline	10-17	p21 (RAC1) activated kinase 1	Gallus gallus	33-36
11927080-9	2002	RESULTS: Both patients showed a thymine deletion in exon 5 at nucleotide 2298 (codon CCT for proline 766) of the androgen receptor gene, causing their phenotype.	Proline	93-100	CCT	Homo sapiens	85-88
11927080-9	2002	RESULTS: Both patients showed a thymine deletion in exon 5 at nucleotide 2298 (codon CCT for proline 766) of the androgen receptor gene, causing their phenotype.	Proline	93-100	androgen receptor	Homo sapiens	113-130
11812777-8	2002	Deletion analyses suggested that the zinc finger domain and the hydrophobic region are not required but the proline-rich region and the HMG box-like domain are indispensable for the DNA binding by the FILAMENTOUS FLOWER protein.	Proline	108-115	Plant-specific transcription factor YABBY family protein	Arabidopsis thaliana	201-219
11923424-1	2002	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase with close structural homology to the mitotic Cdks.	Proline	38-45	cyclin-dependent kinase 5	Rattus norvegicus	0-25
12575207-1	2002	OBJECTIVE: A polymorphism at codon 72 of the human tumor-suppressor gene, p53, results in translation to either arginine or proline.	Proline	124-131	TSC complex subunit 1	Homo sapiens	51-67
12575207-1	2002	OBJECTIVE: A polymorphism at codon 72 of the human tumor-suppressor gene, p53, results in translation to either arginine or proline.	Proline	124-131	tumor protein p53	Homo sapiens	74-77
11923424-1	2002	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase with close structural homology to the mitotic Cdks.	Proline	38-45	cyclin-dependent kinase 5	Rattus norvegicus	27-31
11923424-1	2002	Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase with close structural homology to the mitotic Cdks.	Proline	38-45	cyclin-dependent kinase 5	Rattus norvegicus	125-129
11923441-2	2002	The product of FMR2 is a member of a family of proteins rich in serine and proline, members of which have been associated with transcriptional activation.	Proline	75-82	AF4/FMR2 family, member 2	Mus musculus	15-19
11788604-0	2002	An N-terminal arginine-rich cluster and a proline-alanine-threonine repeat region determine the cellular localization of the herpes simplex virus type 1 ICP34.5 protein and its ligand, protein phosphatase 1.	Proline	42-49	neuropeptide Y receptor Y4	Homo sapiens	185-206
11978535-3	2002	Recent identification of the novel prolyl isomerase Pin1 that specifically isomerizes only the phosphorylated Ser/Thr-Pro bonds in certain proteins led us to propose a new signaling mechanism, whereby prolyl isomerization catalytically induces conformational changes in proteins following phosphorylation to regulate protein function.	Proline	118-121	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	52-56
11790767-8	2002	In contrast, peptides based on the JBDs of ATF2 and c-Jun inhibited JNK activity by &lt;40%, which agreed with their lack of homology to the critical Arg-156 and Pro-157.	Proline	162-165	activating transcription factor 2	Homo sapiens	43-47
11799118-7	2002	The interaction occurs between a proline-rich domain of ACK2 and the Src homology 3 domain (SH3) of SH3PX1.	Proline	33-40	sorting nexin 9	Mus musculus	100-106
11937099-2	2002	Here, we demonstrate that repeated administration of the novel neurotensin-(8-13) analogue NT69L [(N-methyl-Arg), Lys, Pro, L-neo-Trp, tert-Leu, Leu] induce tolerance to its suppressant effect on conditioned avoidance behaviour in rats, a predictive assay for antipsychotic activity.	Proline	119-122	neurotensin	Rattus norvegicus	63-74
11799106-5	2002	Removal of the PEST (proline-glutamic acid-serine-threonine) domain-containing C terminus (amino acids 244-314) abolished the IkappaBalpha function, and the C terminus alone blocked the TGF-beta1 growth-inhibitory effect.	Proline	21-28	NFKB inhibitor alpha	Rattus norvegicus	126-138
11741991-3	2002	Glis2 encodes a relatively proline-rich, basic 55.8-kDa protein.	Proline	27-34	GLIS family zinc finger 2	Mus musculus	0-5
11773052-7	2002	Tyr-56 is located within the SH3 domain of DSH3PX1, placing it in an important position for regulating the binding of proline-rich targets.	Proline	118-125	SH3 and PX domain containing 1	Drosophila melanogaster	43-50
11799106-11	2002	Mapping by yeast two-hybrid showed that the non-ankyrin C terminus of IkappaBalpha physically interacted with the proline-rich region and a phosphorylation site, serine 46, in p53.	Proline	114-121	NFKB inhibitor alpha	Rattus norvegicus	70-82
12009870-10	2002	Sequence analysis of the Cyp A binding regions revealed that the proline-rich motif, which is responsible for Cyp A incorporation, was conserved in all four isolates, while some sequence variations were detected in other positions close to this region.	Proline	65-72	peptidylprolyl isomerase A	Homo sapiens	25-30
11883939-7	2002	The Ca(2+)-dependent fluorescence change of ALG-2 in the presence of the hydrophobicity fluorescent probe 2-p-toluidinylnaphthalene-6-sulfonate (TNS) was inhibited by mixing with GST-AnxN, suggesting that the Pro/Gly/Tyr/Ala-rich hydrophobic region in AnxN masked the Ca(2+)-dependently exposed hydrophobic surface of ALG-2.	Proline	209-212	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	44-49
11883939-7	2002	The Ca(2+)-dependent fluorescence change of ALG-2 in the presence of the hydrophobicity fluorescent probe 2-p-toluidinylnaphthalene-6-sulfonate (TNS) was inhibited by mixing with GST-AnxN, suggesting that the Pro/Gly/Tyr/Ala-rich hydrophobic region in AnxN masked the Ca(2+)-dependently exposed hydrophobic surface of ALG-2.	Proline	209-212	glutathione S-transferase kappa 1	Homo sapiens	179-182
12009870-10	2002	Sequence analysis of the Cyp A binding regions revealed that the proline-rich motif, which is responsible for Cyp A incorporation, was conserved in all four isolates, while some sequence variations were detected in other positions close to this region.	Proline	65-72	peptidylprolyl isomerase A	Homo sapiens	110-115
11733522-12	2002	5) Binding of both p47(phox) and p67(phox) to proline-rich p22(phox) peptides occurs in the absence of an anionic amphiphile.	Proline	46-53	CD33 molecule	Homo sapiens	33-36
11943179-0	2002	A conserved proline residue is present in the transmembrane-spanning domain of Tom7 and other tail-anchored protein subunits of the TOM translocase.	Proline	12-19	translocase of outer mitochondrial membrane 7	Homo sapiens	79-83
11943179-0	2002	A conserved proline residue is present in the transmembrane-spanning domain of Tom7 and other tail-anchored protein subunits of the TOM translocase.	Proline	12-19	pre-mRNA processing factor 6	Homo sapiens	132-135
11943179-3	2002	The carboxy-terminal 33 amino acids of Tom7 contain the information for targeting the protein to the mitochondrial outer membrane, and a conserved proline residue within the transmembrane segment is required for efficient targeting of Tom7 to the outer membrane.	Proline	147-154	translocase of outer mitochondrial membrane 7	Homo sapiens	235-239
11733522-12	2002	5) Binding of both p47(phox) and p67(phox) to proline-rich p22(phox) peptides occurs in the absence of an anionic amphiphile.	Proline	46-53	pleckstrin	Homo sapiens	23-27
11733522-9	2002	2) p47(phox) binds not only to the proline-rich region, located at residues 151-160 in the cytosolic C terminus of p22(phox), but also to a domain (residues 51-63) located on a loop exposed to the cytosol.	Proline	35-42	pleckstrin	Homo sapiens	3-6
11733522-9	2002	2) p47(phox) binds not only to the proline-rich region, located at residues 151-160 in the cytosolic C terminus of p22(phox), but also to a domain (residues 51-63) located on a loop exposed to the cytosol.	Proline	35-42	pleckstrin	Homo sapiens	7-11
11943179-4	2002	An equivalent proline residue is important in targeting each of the other three tail-anchored proteins that associate with Tom40 to form the core of the TOM translocase.	Proline	14-21	translocase of outer mitochondrial membrane 40	Homo sapiens	123-128
11733522-12	2002	5) Binding of both p47(phox) and p67(phox) to proline-rich p22(phox) peptides occurs in the absence of an anionic amphiphile.	Proline	46-53	calcineurin like EF-hand protein 1	Homo sapiens	59-62
11943179-4	2002	An equivalent proline residue is important in targeting each of the other three tail-anchored proteins that associate with Tom40 to form the core of the TOM translocase.	Proline	14-21	pre-mRNA processing factor 6	Homo sapiens	153-156
11733522-9	2002	2) p47(phox) binds not only to the proline-rich region, located at residues 151-160 in the cytosolic C terminus of p22(phox), but also to a domain (residues 51-63) located on a loop exposed to the cytosol.	Proline	35-42	calcineurin like EF-hand protein 1	Homo sapiens	115-118
11733522-9	2002	2) p47(phox) binds not only to the proline-rich region, located at residues 151-160 in the cytosolic C terminus of p22(phox), but also to a domain (residues 51-63) located on a loop exposed to the cytosol.	Proline	35-42	pleckstrin	Homo sapiens	119-123
11733522-12	2002	5) Binding of both p47(phox) and p67(phox) to proline-rich p22(phox) peptides occurs in the absence of an anionic amphiphile.	Proline	46-53	pleckstrin	Homo sapiens	37-41
11733522-10	2002	3) p67(phox) shares with p47(phox) the ability to bind to the proline-rich region (residues 151-160) and also binds to two additional domains, in the cytosolic loop (residues 81-91) and at the start of the cytosolic tail (residues 111-115).	Proline	62-69	CD33 molecule	Homo sapiens	3-6
11733522-10	2002	3) p67(phox) shares with p47(phox) the ability to bind to the proline-rich region (residues 151-160) and also binds to two additional domains, in the cytosolic loop (residues 81-91) and at the start of the cytosolic tail (residues 111-115).	Proline	62-69	pleckstrin	Homo sapiens	7-11
11741963-4	2002	To investigate the role of helix D elongation in the allosteric activation of antithrombin, we substituted a proline residue for Lys(133).	Proline	109-116	serpin family C member 1	Homo sapiens	78-90
11939716-4	2002	METHODS: Culture of rat buccal mucosa in the presence of ethanol and [3H]-labeled proline and palmitate revealed substantial decrease in MBP synthesis and the release of MBPto the medium.	Proline	82-89	myelin basic protein	Rattus norvegicus	137-140
11741963-7	2002	The pentasaccharide-accelerated rate of factor Xa inhibition for the proline variant was 10-fold lower than control, demonstrating that the proline variant cannot be fully activated toward factor Xa.	Proline	69-76	coagulation factor X	Homo sapiens	40-49
11741963-7	2002	The pentasaccharide-accelerated rate of factor Xa inhibition for the proline variant was 10-fold lower than control, demonstrating that the proline variant cannot be fully activated toward factor Xa.	Proline	140-147	coagulation factor X	Homo sapiens	40-49
11870087-5	2002	The amino acid sequence includes 6 Pro-Gly-Pro repeats, which are also present in the human orthologue protein (hSHIPPO 1) as well as in 2 other newly reported proteins of Drosophila melanogaster.	Proline	35-38	outer dense fiber of sperm tails 3	Homo sapiens	112-121
11870087-5	2002	The amino acid sequence includes 6 Pro-Gly-Pro repeats, which are also present in the human orthologue protein (hSHIPPO 1) as well as in 2 other newly reported proteins of Drosophila melanogaster.	Proline	43-46	outer dense fiber of sperm tails 3	Homo sapiens	112-121
11733522-10	2002	3) p67(phox) shares with p47(phox) the ability to bind to the proline-rich region (residues 151-160) and also binds to two additional domains, in the cytosolic loop (residues 81-91) and at the start of the cytosolic tail (residues 111-115).	Proline	62-69	pleckstrin	Homo sapiens	25-28
11733522-10	2002	3) p67(phox) shares with p47(phox) the ability to bind to the proline-rich region (residues 151-160) and also binds to two additional domains, in the cytosolic loop (residues 81-91) and at the start of the cytosolic tail (residues 111-115).	Proline	62-69	pleckstrin	Homo sapiens	29-33
11733522-12	2002	5) Binding of both p47(phox) and p67(phox) to proline-rich p22(phox) peptides occurs in the absence of an anionic amphiphile.	Proline	46-53	pleckstrin	Homo sapiens	19-28
11866478-2	2002	A synthetic peptide corresponding to the Gly(2460)-Pro(2495) domain of the RyR2, designated DPc10, enhanced the ryanodine binding activity and increased the sensitivity of the RyR2 to activating Ca(2+): the effects that resemble the typical phenotypes of cardiac diseases.	Proline	51-54	ryanodine receptor 2	Homo sapiens	75-79
11866478-2	2002	A synthetic peptide corresponding to the Gly(2460)-Pro(2495) domain of the RyR2, designated DPc10, enhanced the ryanodine binding activity and increased the sensitivity of the RyR2 to activating Ca(2+): the effects that resemble the typical phenotypes of cardiac diseases.	Proline	51-54	ryanodine receptor 2	Homo sapiens	176-180
12363219-4	2002	The crystal structure of the complex between the catalytic domain of MMP-8 and Pro-Leu-L-TrpP(OH)2 (PLTP) showed that this phosphonate inhibitor binds in the S side of the active site.	Proline	79-82	matrix metallopeptidase 8	Homo sapiens	69-74
11939716-5	2002	The radioscanning of the samples prepared from the culture medium and the apical epithelial membranes subjected to SDS-PAGE and western blotting disclosed that the released, water soluble 97kDa MBP glycopeptide was labeled with proline and palmitate.	Proline	228-235	myelin basic protein	Rattus norvegicus	194-197
11839818-9	2002	Thus, the unique function of Oct-3/4 in ES cell propagation resides in combination of the specific POU domain with a generic proline-rich transactivation domain.	Proline	125-132	POU class 5 homeobox 1	Homo sapiens	29-36
11955521-8	2002	We conclude that the beta1 subunit M1 segment proline affects the linkage between GABA binding and channel gating and is critical for barbiturate enhancement.	Proline	46-53	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	21-26
11853741-1	2002	The aim of the present work was to examine the relationship between proline metabolism and NAD kinase activity in greenbeans submitted to cold-shock.	Proline	68-75	NAD kinase	Homo sapiens	91-101
11853741-3	2002	Our results indicate that the plants showed foliar accumulation of proline, with the enzymes ornithine-delta-aminotransferase (OAT) and proline dehydrogenase (PDH) appearing as determinant in this accumulation under cold-shock.	Proline	67-74	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	136-157
11853741-3	2002	Our results indicate that the plants showed foliar accumulation of proline, with the enzymes ornithine-delta-aminotransferase (OAT) and proline dehydrogenase (PDH) appearing as determinant in this accumulation under cold-shock.	Proline	67-74	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	159-162
11853741-4	2002	Also, we found a close relationship between the Ca(2+)-CaM-dependent NAD kinase activity and proline metabolism, suggesting that the adaptive responses or acclimation of plants to cold stress are preceded by increased [Ca(2+)](cyt).	Proline	93-100	NAD kinase	Homo sapiens	69-79
11744688-3	2002	CdGAP consists of a N-terminal GAP domain, a central domain, and a C-terminal proline-rich domain.	Proline	78-85	Rho GTPase activating protein 31	Mus musculus	0-5
11911775-5	2002	It has been suggested that these hydrophobic domains, predominantly containing glycine, proline, leucine and valine, often occurring in tandemly repeated sequences, are responsible for the ability of elastin to align monomeric chains for covalent cross-linking.	Proline	88-95	elastin	Homo sapiens	200-207
11729180-5	2002	Amino acid analysis revealed a large proportion of threonine and proline residues in Em2(G11).	Proline	65-72	serine/threonine kinase 19	Homo sapiens	85-92
12006994-7	2002	When all Ser/Thr in Ser/Thr-Pro motif were mutated to Ala, the interaction of YLR190w (mutant) and YAF9 was weakened, and the effect of phosphate concentration was impaired.	Proline	28-31	YEATS domain-containing protein YAF9	Saccharomyces cerevisiae S288C	99-103
11904169-2	2002	The pSer/Thr-Pro moiety exists in the two distinct cis and trans conformations, whose conversion is catalyzed by the peptidyl-prolyl isomerase (PPIase) Pin1.	Proline	13-16	peptidylprolyl isomerase ESS1	Saccharomyces cerevisiae S288C	152-156
11744688-7	2002	Although the C-terminal proline-rich domain of CdGAP is required for the regulation of its GAP activity by intersectin both in vivo and in vitro, it is not necessary for CdGAP-intersectin interaction.	Proline	24-31	Rho GTPase activating protein 31	Mus musculus	47-52
11744688-9	2002	Thus, we propose a model in which intersectin binding results in a change of CdGAP conformation involving the proline-rich domain that leads to the inhibition of its GAP activity.	Proline	110-117	Rho GTPase activating protein 31	Mus musculus	77-82
11709548-3	2002	Here, we define a Pro-Glu-Asp-Ser-Thr-rich element containing 129 amino acid residues, designated IR1+2, on the human nucleoporin RanBP2/Nup358, which binds directly to Ubc9 with high affinity both in vitro and in vivo.	Proline	18-21	RAN binding protein 2	Homo sapiens	130-136
11911879-4	2002	Like Src homology 3, WW and GYF domains and profilin, EVH1 domains recognize and bind specific proline-rich sequences (PRSs).	Proline	95-102	chickadee	Drosophila melanogaster	44-52
11709548-3	2002	Here, we define a Pro-Glu-Asp-Ser-Thr-rich element containing 129 amino acid residues, designated IR1+2, on the human nucleoporin RanBP2/Nup358, which binds directly to Ubc9 with high affinity both in vitro and in vivo.	Proline	18-21	RAN binding protein 2	Homo sapiens	137-143
11709548-3	2002	Here, we define a Pro-Glu-Asp-Ser-Thr-rich element containing 129 amino acid residues, designated IR1+2, on the human nucleoporin RanBP2/Nup358, which binds directly to Ubc9 with high affinity both in vitro and in vivo.	Proline	18-21	ubiquitin conjugating enzyme E2 I	Homo sapiens	169-173
11734558-6	2002	The present data suggest that Pro-2, Asp-6, Pro-8, and Thr-9 are critical for LD78beta binding to CCR5 and HIV-1 replication inhibition, and that LD78beta binding to CCR5, regardless of affinity, is sufficient for the initial signal transduction of LD78beta, whereas the greater anti-HIV-1 activity requires the greater magnitude of binding.	Proline	30-33	C-C motif chemokine ligand 3 like 1	Homo sapiens	78-86
11734558-6	2002	The present data suggest that Pro-2, Asp-6, Pro-8, and Thr-9 are critical for LD78beta binding to CCR5 and HIV-1 replication inhibition, and that LD78beta binding to CCR5, regardless of affinity, is sufficient for the initial signal transduction of LD78beta, whereas the greater anti-HIV-1 activity requires the greater magnitude of binding.	Proline	30-33	C-C motif chemokine receptor 5	Homo sapiens	98-102
11741929-13	2002	Deletion and point mutation analysis of the ADAM15 cytoplasmic domain confirmed the importance of the proline-rich motifs for Grb2 and Lck binding and indicated the regulatory nature of Tyr(715) and Tyr(735).	Proline	102-109	ADAM metallopeptidase domain 15	Homo sapiens	44-50
11834704-7	2002	Exogenous CT-1 markedly stimulated [(3)H]thymidine and [(3)H]proline incorporations (P&lt;0.01), with accumulation of cells in the S phase.	Proline	61-68	cardiotrophin 1	Canis lupus familiaris	10-14
11884082-7	2002	Four proline residues, presumably responsible for changing the backbone direction of protein structure, are conserved in chicken FSH-beta-subunit as well.	Proline	5-12	follicle stimulating hormone beta subunit	Gallus gallus	129-137
11807792-3	2002	A common polymorphism of p53, encoding either proline (Pro) or arginine (Arg) at position 72, affects the susceptibility of p53 to E6 mediated degradation in vivo.	Proline	46-53	tumor protein p53	Homo sapiens	25-28
11807792-3	2002	A common polymorphism of p53, encoding either proline (Pro) or arginine (Arg) at position 72, affects the susceptibility of p53 to E6 mediated degradation in vivo.	Proline	46-53	tumor protein p53	Homo sapiens	124-127
11807792-3	2002	A common polymorphism of p53, encoding either proline (Pro) or arginine (Arg) at position 72, affects the susceptibility of p53 to E6 mediated degradation in vivo.	Proline	55-58	tumor protein p53	Homo sapiens	25-28
11807792-3	2002	A common polymorphism of p53, encoding either proline (Pro) or arginine (Arg) at position 72, affects the susceptibility of p53 to E6 mediated degradation in vivo.	Proline	55-58	tumor protein p53	Homo sapiens	124-127
11814342-6	2002	The conformation-sensitive fluorescence probe, methyl coumarin acetamide (MCA), was incorporated into RyR in a protein- and site-specific manner by using DP4 (the peptide corresponding to the Leu(2442)-Pro(2477) region of the central domain) as a site-directing carrier.	Proline	202-205	ryanodine receptor 1	Homo sapiens	102-105
11814357-2	2002	Two prolines (Pro(-9), Pro(-5)) located near the processing sites (Arg(-15) and Arg(-2)Lys(-)(1)) of human prosomatostatin were previously shown to be important for cleavage of the precursor into somatostatin-28 (S-28) and somatostatin-14 (S-14) [Gomez et al.	Proline	4-12	somatostatin	Homo sapiens	196-211
11814357-2	2002	Two prolines (Pro(-9), Pro(-5)) located near the processing sites (Arg(-15) and Arg(-2)Lys(-)(1)) of human prosomatostatin were previously shown to be important for cleavage of the precursor into somatostatin-28 (S-28) and somatostatin-14 (S-14) [Gomez et al.	Proline	4-12	somatostatin	Homo sapiens	213-217
11830661-8	2002	Structure-activity analyses reveal a single binding site created by the zeta-dimer, with two tyrosine residues important for structural stability and two proline residues important for Fc epsilon RI binding.	Proline	154-161	Fc epsilon receptor Ia	Homo sapiens	185-198
11814357-2	2002	Two prolines (Pro(-9), Pro(-5)) located near the processing sites (Arg(-15) and Arg(-2)Lys(-)(1)) of human prosomatostatin were previously shown to be important for cleavage of the precursor into somatostatin-28 (S-28) and somatostatin-14 (S-14) [Gomez et al.	Proline	4-12	somatostatin	Homo sapiens	223-238
11814357-2	2002	Two prolines (Pro(-9), Pro(-5)) located near the processing sites (Arg(-15) and Arg(-2)Lys(-)(1)) of human prosomatostatin were previously shown to be important for cleavage of the precursor into somatostatin-28 (S-28) and somatostatin-14 (S-14) [Gomez et al.	Proline	4-12	somatostatin	Homo sapiens	240-244
11814357-2	2002	Two prolines (Pro(-9), Pro(-5)) located near the processing sites (Arg(-15) and Arg(-2)Lys(-)(1)) of human prosomatostatin were previously shown to be important for cleavage of the precursor into somatostatin-28 (S-28) and somatostatin-14 (S-14) [Gomez et al.	Proline	14-17	somatostatin	Homo sapiens	196-211
11814357-2	2002	Two prolines (Pro(-9), Pro(-5)) located near the processing sites (Arg(-15) and Arg(-2)Lys(-)(1)) of human prosomatostatin were previously shown to be important for cleavage of the precursor into somatostatin-28 (S-28) and somatostatin-14 (S-14) [Gomez et al.	Proline	14-17	somatostatin	Homo sapiens	213-217
11814357-2	2002	Two prolines (Pro(-9), Pro(-5)) located near the processing sites (Arg(-15) and Arg(-2)Lys(-)(1)) of human prosomatostatin were previously shown to be important for cleavage of the precursor into somatostatin-28 (S-28) and somatostatin-14 (S-14) [Gomez et al.	Proline	14-17	somatostatin	Homo sapiens	223-238
11814357-2	2002	Two prolines (Pro(-9), Pro(-5)) located near the processing sites (Arg(-15) and Arg(-2)Lys(-)(1)) of human prosomatostatin were previously shown to be important for cleavage of the precursor into somatostatin-28 (S-28) and somatostatin-14 (S-14) [Gomez et al.	Proline	14-17	somatostatin	Homo sapiens	240-244
12022946-11	2002	Adenine nucleotide binding to the ANT is inhibited by Cys(159) modification whilst oxidation of Cys(56) increases CyP-D binding to the ANT, probably at Pro(61).	Proline	152-155	peptidylprolyl isomerase F	Homo sapiens	114-119
12022946-11	2002	Adenine nucleotide binding to the ANT is inhibited by Cys(159) modification whilst oxidation of Cys(56) increases CyP-D binding to the ANT, probably at Pro(61).	Proline	152-155	solute carrier family 25 member 6	Homo sapiens	135-138
11809859-1	2002	Agonist activation of endogenous angiotensin II (Ang II) AT(1) receptors expressed in hepatic C9 cells markedly stimulated inositol phosphate production, phosphorylation of the proline-rich tyrosine kinase PyK-2, and ERK activation.	Proline	177-184	angiotensinogen	Homo sapiens	33-47
11861487-0	2002	Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling.	Proline	17-24	Notch	Drosophila melanogaster	86-91
11861487-3	2002	Deltex has two other domains that are presumably involved in protein-protein interactions: a proline-rich motif that binds to SH3-domains, and a RING-H2 finger motif.	Proline	93-100	deltex	Drosophila melanogaster	0-6
11861487-6	2002	A mutant form of Deltex that lacked the proline-rich motif behaved as a dominant-negative form.	Proline	40-47	deltex	Drosophila melanogaster	17-23
11836319-9	2002	Nondiabetic Caucasians with an Ala allele (Pro/Ala group) were more insulin sensitive than those in the Pro/Pro group, as evidenced by a lower homeostasis model assessment index (5.18 +/- 1.33 vs. 6.54 +/- 0.54; P &lt; 0.05) and lower levels of insulin at both the fasting (132 +/- 27 vs. 165 +/- 12 pmol/liter; P = 0.03) and 2 h (688 +/- 103 vs. 10190 +/- 99 pmol/liter; P = 0.04) time points during the oral glucose tolerance test.	Proline	43-46	insulin	Homo sapiens	68-75
11836319-9	2002	Nondiabetic Caucasians with an Ala allele (Pro/Ala group) were more insulin sensitive than those in the Pro/Pro group, as evidenced by a lower homeostasis model assessment index (5.18 +/- 1.33 vs. 6.54 +/- 0.54; P &lt; 0.05) and lower levels of insulin at both the fasting (132 +/- 27 vs. 165 +/- 12 pmol/liter; P = 0.03) and 2 h (688 +/- 103 vs. 10190 +/- 99 pmol/liter; P = 0.04) time points during the oral glucose tolerance test.	Proline	43-46	insulin	Homo sapiens	245-252
11792550-2	2002	Members of the Ena/VASP (Drosophila Enabled/vasodilator-stimulated phosphoprotein) family are key players in regulating actin filament assembly, in many cases through their association with binding partners that display a particular proline-rich motif, FPPPP.	Proline	233-240	Actin 79B	Drosophila melanogaster	120-125
12047101-2	2002	The products contained tripeptides isoleucine-proline-proline (IPP) and valine-proline-proline (VPP), which have been shown to possess angiotensin converting enzyme (ACE) inhibitory activity.	Proline	46-53	angiotensin I converting enzyme	Rattus norvegicus	166-169
11826110-6	2002	Yeast cell and SPR analyses also demonstrated the possibility that the FH1 proline-rich region of Delphilin interacts with profilin, an actin-binding protein, and with the Src homology 3 domain of neuronal Src protein tyrosine kinase.	Proline	75-82	profilin	Saccharomyces cerevisiae S288C	123-131
11818515-7	2002	The phospho-Ser/Thr-Pro content (characteristic of ERK1/2 substrates) of Triton-insoluble proteins (75 and 80 kDa) increased during capacitation and also appeared to be regulated by O(2)(-)* and the ERK pathway.	Proline	20-23	mitogen-activated protein kinase 3	Homo sapiens	51-57
11818515-7	2002	The phospho-Ser/Thr-Pro content (characteristic of ERK1/2 substrates) of Triton-insoluble proteins (75 and 80 kDa) increased during capacitation and also appeared to be regulated by O(2)(-)* and the ERK pathway.	Proline	20-23	mitogen-activated protein kinase 1	Homo sapiens	51-54
11809859-1	2002	Agonist activation of endogenous angiotensin II (Ang II) AT(1) receptors expressed in hepatic C9 cells markedly stimulated inositol phosphate production, phosphorylation of the proline-rich tyrosine kinase PyK-2, and ERK activation.	Proline	177-184	angiotensinogen	Homo sapiens	49-55
12052036-3	2002	The conserved regions of FAAH are described in terms of sequence and function, including the domains that contains the serine catalytic nucleophile, the hydrophobic domain important for self-association, the proline rich domain region which may be important for subcellular localization and the fatty acid chain binding domain.	Proline	208-215	fatty acid amide hydrolase	Mus musculus	25-29
11952151-2	2002	The primary structure of Annexins I, III, VII, VIII and XI contain a region enriched in proline, glutamate, serine and threonine (PEST sequences) towards the N-terminal end while annexins II, V and VI possess PEST regions somewhat distal to the N-terminus.	Proline	88-95	annexin A7	Homo sapiens	25-45
11952151-2	2002	The primary structure of Annexins I, III, VII, VIII and XI contain a region enriched in proline, glutamate, serine and threonine (PEST sequences) towards the N-terminal end while annexins II, V and VI possess PEST regions somewhat distal to the N-terminus.	Proline	88-95	cytochrome c oxidase subunit 8A	Homo sapiens	47-51
11840343-4	2002	Here, we present evidence that c-Abl induces the phosphorylation of p73 in threonine residues adjacent to prolines, and that the p38 MAP kinase pathway mediates this response.	Proline	106-114	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	31-36
11840343-4	2002	Here, we present evidence that c-Abl induces the phosphorylation of p73 in threonine residues adjacent to prolines, and that the p38 MAP kinase pathway mediates this response.	Proline	106-114	tumor protein p73	Homo sapiens	68-71
11717310-2	2002	The molecular basis for the interaction of Nedd4 with substrates lies in its WW domains, which can bind proline-rich (PY) domains in target proteins.	Proline	104-111	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	43-48
11696550-4	2002	This interaction is mediated through a specific proline-rich domain in the N-terminal region of Alx4 and requires the DNA-binding domain (HMG-box) of LEF-1.	Proline	48-55	aristaless-like homeobox 4	Mus musculus	96-100
11790096-6	2002	Using circular dichroism and proline mutagenesis, we demonstrate that the unbound p27 Cdk-inhibition domain is not completely unfolded.	Proline	29-36	interferon alpha inducible protein 27	Homo sapiens	82-85
11790096-8	2002	Increasing or reducing the stability of the partially preformed alpha-helix in the isolated p27 domain with alanine or proline substitutions did not affect formation of the p27-inhibited cyclin A-Cdk2 complex in energetic terms.	Proline	119-126	interferon alpha inducible protein 27	Homo sapiens	92-95
11782434-0	2002	Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif.	Proline	81-88	SMAD family member 2	Danio rerio	10-15
11782434-0	2002	Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif.	Proline	81-88	SMAD family member 2	Danio rerio	61-66
11782434-4	2002	Molecular modelling, supported by mutational analyses of Smad2 and the SIM and the demonstration that the SARA SBD competes directly with the SIM for binding to Smad2, indicates that the SIM binds Smad2 in the same hydrophobic pocket as does the proline-rich rigid coil region of the SARA SBD.	Proline	246-253	SMAD family member 2	Danio rerio	161-166
11782434-4	2002	Molecular modelling, supported by mutational analyses of Smad2 and the SIM and the demonstration that the SARA SBD competes directly with the SIM for binding to Smad2, indicates that the SIM binds Smad2 in the same hydrophobic pocket as does the proline-rich rigid coil region of the SARA SBD.	Proline	246-253	SMAD family member 2	Danio rerio	161-166
11782434-5	2002	Thus, different Smad2 partners, whether cytoplasmic or nuclear, interact with the same binding pocket in Smad2 through a common proline-rich motif.	Proline	128-135	SMAD family member 2	Danio rerio	16-21
11782434-5	2002	Thus, different Smad2 partners, whether cytoplasmic or nuclear, interact with the same binding pocket in Smad2 through a common proline-rich motif.	Proline	128-135	SMAD family member 2	Danio rerio	105-110
11812148-6	2002	A double mutant A53T/A30P alpha-Syn showed defective membrane binding similar to the A30P protein, indicating that the proline mutation is dominant in terms of impairing the membrane-binding activity.	Proline	119-126	synuclein, alpha	Mus musculus	26-35
11696550-4	2002	This interaction is mediated through a specific proline-rich domain in the N-terminal region of Alx4 and requires the DNA-binding domain (HMG-box) of LEF-1.	Proline	48-55	lymphoid enhancer binding factor 1	Mus musculus	150-155
11773615-2	2002	Although the biological activities of MIF are presumed to require a receptor-based mechanism of action, the protein is also a tautomerase and has a catalytically active N-terminal proline that is invariant in structurally homologous bacterial isomerases.	Proline	180-187	macrophage migration inhibitory factor	Homo sapiens	38-41
11791172-0	2002	The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells.	Proline	4-11	tumor protein p53	Homo sapiens	27-30
11878910-10	2002	However, this mutation not only changes Pro 609 of nsP4 to Thr, it also changes the nucleotide at the minus sign5 position of the SG promoter.	Proline	40-43	serine protease 57	Homo sapiens	51-55
11782545-7	2002	Although dynamin localization to the tails required its proline-rich domain, expression of a dynamin mutant lacking this domain also diminished tail formation.	Proline	56-63	shibire	Drosophila melanogaster	9-16
11684687-2	2002	Tec family kinases share similarities in domain structure with Src family kinases, but one of the features that differentiates them is a proline-rich region (PRR) preceding their Src homology (SH) 3 domain.	Proline	137-144	tec protein tyrosine kinase	Homo sapiens	0-3
11787059-0	2002	Proline-rich transcript of the brain (prtb) is a serum-responsive gene in osteoblasts and upregulated during adhesion.	Proline	0-7	DAZ associated protein 2	Mus musculus	38-42
11856333-1	2002	The functional site of "phospholipase A2 inhibitor from python" (PIP) was predicted based on the hypothesis of proline brackets.	Proline	111-118	phospholipase A2 group IB	Homo sapiens	24-40
16233323-1	2002	In Saccharomyces cerevisiae, the PUT1-encoded proline oxidase and the PUT2-encoded delta1-pyrroline-5-carboxylate dehydrogenase are required to convert proline to glutamate.	Proline	46-53	proline dehydrogenase	Saccharomyces cerevisiae S288C	33-37
16233323-1	2002	In Saccharomyces cerevisiae, the PUT1-encoded proline oxidase and the PUT2-encoded delta1-pyrroline-5-carboxylate dehydrogenase are required to convert proline to glutamate.	Proline	46-53	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	70-74
16233323-2	2002	We recently showed that a put1 disruptant accumulated higher levels of proline intracellularly and conferred higher resistance to freezing stress.	Proline	71-78	proline dehydrogenase	Saccharomyces cerevisiae S288C	26-30
16233323-4	2002	When grown on arginine as the sole nitrogen source, the put2 disruptant showed a significant decrease in cell viability after freezing despite the high proline and arginine contents.	Proline	152-159	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	56-60
11751303-2	2002	The domain corresponding to Thr(671)-Leu(690) of the II-III loop of the skeletal DHPR alpha(1)-subunit is able to regulate RyR properties and calcium release from sarcoplasmic reticulum, whereas the domain corresponding to Glu(724)-Pro(760) antagonizes this effect.	Proline	232-235	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	81-102
11779589-0	2002	The proline form of p53 codon 72 polymorphism is associated with endometriosis.	Proline	4-11	tumor protein p53	Homo sapiens	20-23
11733182-10	2002	Prolidase activity was almost 3-fold lower in the preeclamptic extract (240.6+/-29.3 nmol Pro x min(-1) x mg(-1) protein) in comparison to the control (608.2+/-63.7 nmol Pro x min(-1) x mg(-1)protein).	Proline	90-93	peptidase D	Homo sapiens	0-9
14577491-10	2002	P53 mutation was confirmed only in 1 patient with pTaG2 tumor in exon 5 (deletion of proline 128).	Proline	85-92	tumor protein p53	Homo sapiens	0-3
11787050-2	2002	The prolyl isomerase Pin1 plays an important role in cell cycle regulation through its specific interaction with proteins that are phosphorylated at Ser/Thr-Pro motifs.	Proline	157-160	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	21-25
11751969-8	2002	Affinity-enhancing substitutions frequently involved replacement of a negative charge, or Gly or Pro, hallmark amino acids of CII structure.	Proline	97-100	serpin family D member 1	Homo sapiens	126-129
11773235-1	2002	DP4 is a 36-residue synthetic peptide that corresponds to the Leu(2442)-Pro(2477) region of RyR1 that contains the reported malignant hyperthermia (MH) mutation site.	Proline	72-75	transcription factor Dp family member 3	Homo sapiens	0-3
11773235-1	2002	DP4 is a 36-residue synthetic peptide that corresponds to the Leu(2442)-Pro(2477) region of RyR1 that contains the reported malignant hyperthermia (MH) mutation site.	Proline	72-75	ryanodine receptor 1	Homo sapiens	92-96
12785105-2	2002	Its soluble precursor (tropoelastin) has two major types of alternating domains: (1) hydrophilic cross-linked domains rich in Lys and Ala and (2) hydrophobic domains (responsible for elasticity) rich in Val, Pro, and Gly, which often occur in repeats of VPGVG or VGGVG.	Proline	208-211	elastin	Homo sapiens	23-35
12207158-0	2002	The analgesic domain of interferon-alpha2b contains an essential proline(39) residue.	Proline	65-72	interferon alpha 2	Homo sapiens	24-42
12064946-1	2002	The PEVK domain of the giant muscle protein titin is a proline-rich sequence with unknown secondary/tertiary structure.	Proline	55-62	titin	Homo sapiens	44-49
11802048-0	2002	Prognostic significance of the proline form of p53 codon 72 polymorphism in nasopharyngeal carcinoma.	Proline	31-38	tumor protein p53	Homo sapiens	47-50
12025816-3	2002	The actions of Notch can be antagonized by Numb, an evolutionarily conserved protein that exists in four isoforms that differ in two functional domains: a phosphotyrosine-binding (PTB) domain and a proline-rich region (PRR).	Proline	198-205	NUMB endocytic adaptor protein	Mus musculus	43-47
12207158-6	2002	RESULTS: When the Pro(39) residue of IFN-alpha, which is located close to the Tyr(122) residue in the tertiary structure, was mutated to Gly, the analgesic activity of this mutant was lost completely, but the antiviral activity of IFN-alpha was maintained compared with wild-type IFN-alpha.	Proline	18-21	interferon alpha 2	Homo sapiens	37-46
12207158-6	2002	RESULTS: When the Pro(39) residue of IFN-alpha, which is located close to the Tyr(122) residue in the tertiary structure, was mutated to Gly, the analgesic activity of this mutant was lost completely, but the antiviral activity of IFN-alpha was maintained compared with wild-type IFN-alpha.	Proline	18-21	interferon alpha 2	Homo sapiens	231-240
12207158-6	2002	RESULTS: When the Pro(39) residue of IFN-alpha, which is located close to the Tyr(122) residue in the tertiary structure, was mutated to Gly, the analgesic activity of this mutant was lost completely, but the antiviral activity of IFN-alpha was maintained compared with wild-type IFN-alpha.	Proline	18-21	interferon alpha 2	Homo sapiens	231-240
12403639-1	2002	UNLABELLED: Insulin lispro is a recombinant insulin analogue with transposed amino acids (proline and lysine) at positions 28 and 29 near the C-terminus of the B-chain.	Proline	90-97	insulin	Homo sapiens	12-19
11814622-7	2002	Consistently, [Leu(31),Pro(34)]-NPY induced trans-CREB mediated luciferase activity through a CaM kinase dependent pathway, and inhibited forskolin-stimulated luciferase gene expression.	Proline	23-26	neuropeptide Y	Homo sapiens	32-35
11814622-7	2002	Consistently, [Leu(31),Pro(34)]-NPY induced trans-CREB mediated luciferase activity through a CaM kinase dependent pathway, and inhibited forskolin-stimulated luciferase gene expression.	Proline	23-26	cAMP responsive element binding protein 1	Homo sapiens	50-54
11814622-2	2002	The Y(1) receptor agonist, [Leu(31),Pro(34)]-NPY, inhibited forskolin-stimulated cAMP production which was insensitive to thapsigargin or the CaM kinase II inhibitor, KN-93.	Proline	36-39	neuropeptide Y	Homo sapiens	45-48
12403639-1	2002	UNLABELLED: Insulin lispro is a recombinant insulin analogue with transposed amino acids (proline and lysine) at positions 28 and 29 near the C-terminus of the B-chain.	Proline	90-97	insulin	Homo sapiens	44-51
11842235-1	2002	The thermal stability of alpha-glucosidase is important because the conversion of starch to fermentable sugars during industrial production of ethanol (e.g. brewing, fuel ethanol production) typically takes place at temperatures of 65-73 degrees C. In this study we investigate the thermostability of alpha-glucosidases from four plant species, compare their deduced amino acid sequences, and test the effect of substituting a proline for the residue present in the wild-type enzyme on the thermostability of alpha-glucosidase.	Proline	427-434	Agl1	Hordeum vulgare	25-42
11742120-2	2002	The Btk fragment studied contains two consecutive proline-rich motifs followed by a single Src homology 3 (SH3) domain.	Proline	50-57	Bruton tyrosine kinase	Homo sapiens	4-7
11742120-8	2002	Thus, changes in the local concentration of Btk itself, or co-localization with exogenous signaling molecules that have high affinity for either proline sequence or the SH3 domain, can significantly alter species composition and regulate Btk kinase activity.	Proline	145-152	Bruton tyrosine kinase	Homo sapiens	44-47
11742120-8	2002	Thus, changes in the local concentration of Btk itself, or co-localization with exogenous signaling molecules that have high affinity for either proline sequence or the SH3 domain, can significantly alter species composition and regulate Btk kinase activity.	Proline	145-152	Bruton tyrosine kinase	Homo sapiens	238-241
11842235-0	2002	The effect of proline insertions on the thermostability of a barley alpha-glucosidase.	Proline	14-21	Agl1	Hordeum vulgare	68-85
11842235-4	2002	Site-directed mutagenesis was done on recombinant barley alpha-glucosidase to create proteins with prolines at these conserved positions.	Proline	99-107	Agl1	Hordeum vulgare	57-74
11744164-4	2001	A region rich in serine, threonine, proline, and tyrosine from amino acids 312-367 was sufficient to activate transcription at low levels when coupled to amino acids 1-86, which contain the DNA-binding (MADS/MEF) domain of MEF2C, but also depended on amino acids 87-311 for full effect.	Proline	36-43	myocyte enhancer factor 2C	Homo sapiens	223-228
11604401-2	2001	The MKK C-terminal region contains a proline-rich region that reportedly functions in regulating interactions with the Raf-1 kinase and ERK activity.	Proline	37-44	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	119-124
11604401-2	2001	The MKK C-terminal region contains a proline-rich region that reportedly functions in regulating interactions with the Raf-1 kinase and ERK activity.	Proline	37-44	mitogen-activated protein kinase 1	Homo sapiens	136-139
11756613-4	2001	The resulting leucine to proline substitution likely modifies the secondary structure of the ANT1 protein.	Proline	25-32	solute carrier family 25 member 4	Homo sapiens	93-97
11878897-1	2001	The small 11-kDa proteins of B19 parvovirus contain three proline-rich regions which conform to consensus Src homology 3 (SH3) ligand sequences present in signaling molecules within the cell.	Proline	58-65	eva-1 homolog C	Homo sapiens	29-32
11878897-3	2001	Mutation of prolines within one of the three SH3 ligand-like sequences decreases the binding of B19 11-kDa proteins to Grb2, suggesting that the proline-rich region is involved in the B19 11-kDa/Grb2 interaction.	Proline	12-20	eva-1 homolog C	Homo sapiens	96-99
11878897-3	2001	Mutation of prolines within one of the three SH3 ligand-like sequences decreases the binding of B19 11-kDa proteins to Grb2, suggesting that the proline-rich region is involved in the B19 11-kDa/Grb2 interaction.	Proline	12-20	growth factor receptor bound protein 2	Homo sapiens	119-123
11878897-3	2001	Mutation of prolines within one of the three SH3 ligand-like sequences decreases the binding of B19 11-kDa proteins to Grb2, suggesting that the proline-rich region is involved in the B19 11-kDa/Grb2 interaction.	Proline	12-20	eva-1 homolog C	Homo sapiens	184-187
11878897-3	2001	Mutation of prolines within one of the three SH3 ligand-like sequences decreases the binding of B19 11-kDa proteins to Grb2, suggesting that the proline-rich region is involved in the B19 11-kDa/Grb2 interaction.	Proline	12-20	growth factor receptor bound protein 2	Homo sapiens	195-199
11878897-3	2001	Mutation of prolines within one of the three SH3 ligand-like sequences decreases the binding of B19 11-kDa proteins to Grb2, suggesting that the proline-rich region is involved in the B19 11-kDa/Grb2 interaction.	Proline	12-19	eva-1 homolog C	Homo sapiens	96-99
11602598-5	2001	Pilt has a proline-rich domain.	Proline	11-18	tight junction associated protein 1	Homo sapiens	0-4
11878897-3	2001	Mutation of prolines within one of the three SH3 ligand-like sequences decreases the binding of B19 11-kDa proteins to Grb2, suggesting that the proline-rich region is involved in the B19 11-kDa/Grb2 interaction.	Proline	12-19	growth factor receptor bound protein 2	Homo sapiens	119-123
11878897-3	2001	Mutation of prolines within one of the three SH3 ligand-like sequences decreases the binding of B19 11-kDa proteins to Grb2, suggesting that the proline-rich region is involved in the B19 11-kDa/Grb2 interaction.	Proline	12-19	eva-1 homolog C	Homo sapiens	184-187
11878897-3	2001	Mutation of prolines within one of the three SH3 ligand-like sequences decreases the binding of B19 11-kDa proteins to Grb2, suggesting that the proline-rich region is involved in the B19 11-kDa/Grb2 interaction.	Proline	12-19	growth factor receptor bound protein 2	Homo sapiens	195-199
11577104-7	2001	The cytoplasmic protein tyrosine phosphatase (PTP)-proline-glutamic acid-serine-threonine amino acid sequences (PEST) was also found to be associated with gelsolin in osteoclast podosomes and with stimulation of alpha(v)beta(3)-regulated phosphorylation of PTP-PEST.	Proline	51-58	protein tyrosine phosphatase receptor type U	Homo sapiens	46-49
11755200-5	2001	Among the rare group of proline-specific proteases, dipeptidyl peptidase IV (DPP-IV, EC 3.4.14.5) was originally believed to be the only membrane-bound enzyme specific for proline as the penultimate residue at the amino-terminus of the polypeptide chain.	Proline	24-31	dipeptidyl peptidase 4	Homo sapiens	52-75
11755200-5	2001	Among the rare group of proline-specific proteases, dipeptidyl peptidase IV (DPP-IV, EC 3.4.14.5) was originally believed to be the only membrane-bound enzyme specific for proline as the penultimate residue at the amino-terminus of the polypeptide chain.	Proline	24-31	dipeptidyl peptidase 4	Homo sapiens	77-83
11755200-5	2001	Among the rare group of proline-specific proteases, dipeptidyl peptidase IV (DPP-IV, EC 3.4.14.5) was originally believed to be the only membrane-bound enzyme specific for proline as the penultimate residue at the amino-terminus of the polypeptide chain.	Proline	172-179	dipeptidyl peptidase 4	Homo sapiens	52-75
11755200-5	2001	Among the rare group of proline-specific proteases, dipeptidyl peptidase IV (DPP-IV, EC 3.4.14.5) was originally believed to be the only membrane-bound enzyme specific for proline as the penultimate residue at the amino-terminus of the polypeptide chain.	Proline	172-179	dipeptidyl peptidase 4	Homo sapiens	77-83
11577104-7	2001	The cytoplasmic protein tyrosine phosphatase (PTP)-proline-glutamic acid-serine-threonine amino acid sequences (PEST) was also found to be associated with gelsolin in osteoclast podosomes and with stimulation of alpha(v)beta(3)-regulated phosphorylation of PTP-PEST.	Proline	51-58	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	257-265
11577104-7	2001	The cytoplasmic protein tyrosine phosphatase (PTP)-proline-glutamic acid-serine-threonine amino acid sequences (PEST) was also found to be associated with gelsolin in osteoclast podosomes and with stimulation of alpha(v)beta(3)-regulated phosphorylation of PTP-PEST.	Proline	51-58	gelsolin	Homo sapiens	155-163
11716780-6	2001	Kinetic studies indicated that TGF-beta 1-induced l-proline transport was mediated by an increase in transport capacity independent of any changes in the affinity for l-proline.	Proline	50-59	transforming growth factor beta 1	Homo sapiens	31-41
11726515-4	2001	Tyr209 within the C-terminal SH3 domain of Grb2 was identified as one of the tyrosine phosphorylation sites, and phosphorylation of Tyr209 abolished the binding of the SH3 domain to a proline-rich Sos peptide in vitro.	Proline	184-191	growth factor receptor bound protein 2	Homo sapiens	43-47
11716780-0	2001	Transforming growth factor-beta 1 stimulates vascular smooth muscle cell L-proline transport by inducing system A amino acid transporter 2 (SAT2) gene expression.	Proline	73-82	transforming growth factor beta 1	Homo sapiens	0-33
11738817-2	2001	GLIS2 is a relatively proline-rich, basic protein of 55.7 kDa in size.	Proline	22-29	GLIS family zinc finger 2	Homo sapiens	0-5
11590155-9	2001	Mutation of this sole proline abrogates SH3 binding and increases MLK3 catalytic activity.	Proline	22-29	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	66-70
11590155-11	2001	The critical proline residue in the SH3-binding site of MLK3 is conserved in the closely related family members, MLK1 and MLK2, suggesting a common autoinhibitory mechanism among these kinases.	Proline	13-20	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	56-60
11590155-11	2001	The critical proline residue in the SH3-binding site of MLK3 is conserved in the closely related family members, MLK1 and MLK2, suggesting a common autoinhibitory mechanism among these kinases.	Proline	13-20	mitogen-activated protein kinase kinase kinase 9	Homo sapiens	113-117
11590155-11	2001	The critical proline residue in the SH3-binding site of MLK3 is conserved in the closely related family members, MLK1 and MLK2, suggesting a common autoinhibitory mechanism among these kinases.	Proline	13-20	mitogen-activated protein kinase kinase kinase 10	Homo sapiens	122-126
11717497-3	2001	At the N-terminus of grancalcin there is a approximately 50 residue-long segment rich in glycines and prolines.	Proline	102-110	grancalcin	Homo sapiens	21-31
11935380-3	2001	The objective of the present study was to investigate the effects of angiotensin II on (3)H-thymidine and (3)H-proline incorporation in vascular smooth muscle cells in culture and in the tunica media of blood vessels perfused at normal physiological pressures in organ culture, thus avoiding the phenotypic changes observed in cell culture.	Proline	111-118	angiotensinogen	Rattus norvegicus	69-83
11716780-0	2001	Transforming growth factor-beta 1 stimulates vascular smooth muscle cell L-proline transport by inducing system A amino acid transporter 2 (SAT2) gene expression.	Proline	73-82	solute carrier family 38 member 2	Homo sapiens	105-138
11716780-0	2001	Transforming growth factor-beta 1 stimulates vascular smooth muscle cell L-proline transport by inducing system A amino acid transporter 2 (SAT2) gene expression.	Proline	73-82	solute carrier family 38 member 2	Homo sapiens	140-144
11716780-2	2001	Since l-proline is essential for the synthesis of collagen, we examined whether TGF-beta 1 regulates the transcellular transport of l-proline by vascular SMCs.	Proline	132-141	transforming growth factor beta 1	Homo sapiens	80-90
11716780-4	2001	Treatment of SMCs with TGF-beta 1 stimulated l-proline transport in a concentration- and time-dependent manner.	Proline	45-54	transforming growth factor beta 1	Homo sapiens	23-33
11716780-6	2001	Kinetic studies indicated that TGF-beta 1-induced l-proline transport was mediated by an increase in transport capacity independent of any changes in the affinity for l-proline.	Proline	167-176	transforming growth factor beta 1	Homo sapiens	31-41
11716780-7	2001	TGF-beta 1 stimulated the expression of system A amino acid transporter 2 (SAT2) mRNA in a time-dependent fashion that paralleled the increase in l-proline transport.	Proline	146-155	transforming growth factor beta 1	Homo sapiens	0-10
11716780-7	2001	TGF-beta 1 stimulated the expression of system A amino acid transporter 2 (SAT2) mRNA in a time-dependent fashion that paralleled the increase in l-proline transport.	Proline	146-155	solute carrier family 38 member 2	Homo sapiens	40-73
11716780-5	2001	The TGF-beta 1-mediated l-proline uptake was inhibited by cycloheximide or actinomycin D.	Proline	24-33	transforming growth factor beta 1	Homo sapiens	4-14
11716780-7	2001	TGF-beta 1 stimulated the expression of system A amino acid transporter 2 (SAT2) mRNA in a time-dependent fashion that paralleled the increase in l-proline transport.	Proline	146-155	solute carrier family 38 member 2	Homo sapiens	75-79
11716780-9	2001	These results demonstrate that l-proline transport by vascular SMCs is mediated predominantly by the SAT and that TGF-beta 1 stimulates SMC l-proline uptake by inducing the expression of the SAT2 gene.	Proline	140-149	transforming growth factor beta 1	Homo sapiens	114-124
11716780-9	2001	These results demonstrate that l-proline transport by vascular SMCs is mediated predominantly by the SAT and that TGF-beta 1 stimulates SMC l-proline uptake by inducing the expression of the SAT2 gene.	Proline	140-149	solute carrier family 38 member 2	Homo sapiens	191-195
11716780-10	2001	The ability of TGF-beta 1 to induce SAT2 expression may function to provide SMCs with the necessary levels of l-proline required for collagen synthesis and cell growth.	Proline	110-119	transforming growth factor beta 1	Homo sapiens	15-25
11716780-10	2001	The ability of TGF-beta 1 to induce SAT2 expression may function to provide SMCs with the necessary levels of l-proline required for collagen synthesis and cell growth.	Proline	110-119	solute carrier family 38 member 2	Homo sapiens	36-40
11810195-1	2001	Vasodilator-stimulated phosphoprotein (VASP) and mammalian Enabled (Mena) are members of the proline-rich Ena/VASP protein family that links the cell membrane proteins, signal transduction pathways, and the actin cytoskeleton.	Proline	93-100	vasodilator stimulated phosphoprotein	Homo sapiens	0-37
11810195-1	2001	Vasodilator-stimulated phosphoprotein (VASP) and mammalian Enabled (Mena) are members of the proline-rich Ena/VASP protein family that links the cell membrane proteins, signal transduction pathways, and the actin cytoskeleton.	Proline	93-100	vasodilator stimulated phosphoprotein	Homo sapiens	39-43
11810195-1	2001	Vasodilator-stimulated phosphoprotein (VASP) and mammalian Enabled (Mena) are members of the proline-rich Ena/VASP protein family that links the cell membrane proteins, signal transduction pathways, and the actin cytoskeleton.	Proline	93-100	ENAH actin regulator	Homo sapiens	49-66
11810195-1	2001	Vasodilator-stimulated phosphoprotein (VASP) and mammalian Enabled (Mena) are members of the proline-rich Ena/VASP protein family that links the cell membrane proteins, signal transduction pathways, and the actin cytoskeleton.	Proline	93-100	ENAH actin regulator	Homo sapiens	68-72
11810195-1	2001	Vasodilator-stimulated phosphoprotein (VASP) and mammalian Enabled (Mena) are members of the proline-rich Ena/VASP protein family that links the cell membrane proteins, signal transduction pathways, and the actin cytoskeleton.	Proline	93-100	vasodilator stimulated phosphoprotein	Homo sapiens	110-114
11500494-8	2001	In proline-grown cells lacking Npr1, a protein kinase involved in the control of Gap1 trafficking, newly synthesized Gap1 is sorted from the Golgi to the vacuole without passing through the plasma membrane (accompanying article, De Craene, J.-O., Soetens, O., and Andre, B.	Proline	3-10	serine/threonine protein kinase NPR1	Saccharomyces cerevisiae S288C	31-35
11734579-4	2001	The Lp[a]-TRL complex was resistant to dissociation by ultracentrifugation (UCF) alone, but was quantitatively dissociated by UCF in the presence of 100 mM proline.	Proline	156-163	lipoprotein(a)	Homo sapiens	4-8
12005420-4	2001	These results suggest that a proline kink in alpha-helical antibiotic peptide P18 serves as a hinge region to facilitate ion channel formation on bacterial cell membranes and thus plays an important role in providing high selectivity against bacterial cells.	Proline	29-36	H3 histone pseudogene 12	Homo sapiens	78-81
11571291-6	2001	In contrast, IkappaBalpha contacts only one NF-kappaB NLS and employs its carboxyl-terminal proline, glutamic acid, serine, and threonine-rich region for high affinity NF-kappaB binding.	Proline	92-99	NFKB inhibitor alpha	Homo sapiens	13-25
11571291-6	2001	In contrast, IkappaBalpha contacts only one NF-kappaB NLS and employs its carboxyl-terminal proline, glutamic acid, serine, and threonine-rich region for high affinity NF-kappaB binding.	Proline	92-99	nuclear factor kappa B subunit 1	Homo sapiens	168-177
11733144-1	2001	NR-binding SET-domain-containing protein (NSD1) is a mouse nuclear protein containing su(var)3-9, enhancer-of-zeste, trithorax (SET), proline-tryptophan-tryptophan-proline (PWWP) and plant homeodomain protein (PHD)-finger domains (Huang et al., EMBO J.	Proline	134-141	nuclear receptor-binding SET-domain protein 1	Mus musculus	42-46
11733144-1	2001	NR-binding SET-domain-containing protein (NSD1) is a mouse nuclear protein containing su(var)3-9, enhancer-of-zeste, trithorax (SET), proline-tryptophan-tryptophan-proline (PWWP) and plant homeodomain protein (PHD)-finger domains (Huang et al., EMBO J.	Proline	164-171	nuclear receptor-binding SET-domain protein 1	Mus musculus	42-46
11734858-8	2001	Currents can be stimulated further by mutating a proline-tyrosine (PY) motif on barttin.	Proline	49-56	barttin CLCNK type accessory subunit beta	Homo sapiens	80-87
11810239-8	2001	This demonstrates that these two serine residues, each of which is followed by a proline residue, are target sites for phosphorylation by cyclin A-associated kinase.	Proline	81-88	cyclin A2	Homo sapiens	138-146
11743107-2	2001	Unlike other members of the papain family, RD21 has a C-terminal extension sequence composed of two domains, a 2-kD proline-rich domain and a 10-kD domain homologous to animal epithelin/granulin family proteins.	Proline	116-123	Granulin repeat cysteine protease family protein	Arabidopsis thaliana	43-47
11500493-2	2001	In cells growing on proline or urea as the sole nitrogen source, newly synthesized Gap1 is delivered to the plasma membrane, where it accumulates.	Proline	20-27	amino acid permease GAP1	Saccharomyces cerevisiae S288C	83-87
11500493-6	2001	We show that Npr1 is required for stabilization of Gap1 at the plasma membrane: when an npr1(ts) mutant growing on proline is shifted to the restrictive temperature, Gap1 down-regulation is triggered, as it is when NH(4)(+) is added to wild-type cells.	Proline	115-122	serine/threonine protein kinase NPR1	Saccharomyces cerevisiae S288C	13-17
11500493-6	2001	We show that Npr1 is required for stabilization of Gap1 at the plasma membrane: when an npr1(ts) mutant growing on proline is shifted to the restrictive temperature, Gap1 down-regulation is triggered, as it is when NH(4)(+) is added to wild-type cells.	Proline	115-122	serine/threonine protein kinase NPR1	Saccharomyces cerevisiae S288C	88-92
11500494-8	2001	In proline-grown cells lacking Npr1, a protein kinase involved in the control of Gap1 trafficking, newly synthesized Gap1 is sorted from the Golgi to the vacuole without passing through the plasma membrane (accompanying article, De Craene, J.-O., Soetens, O., and Andre, B.	Proline	3-10	amino acid permease GAP1	Saccharomyces cerevisiae S288C	81-85
11500494-8	2001	In proline-grown cells lacking Npr1, a protein kinase involved in the control of Gap1 trafficking, newly synthesized Gap1 is sorted from the Golgi to the vacuole without passing through the plasma membrane (accompanying article, De Craene, J.-O., Soetens, O., and Andre, B.	Proline	3-10	amino acid permease GAP1	Saccharomyces cerevisiae S288C	117-121
11707417-4	2001	Using genetic mapping, we have identified a proline to serine allelic variation at amino acid 180 of the GCD1 gene product as the genetic locus that allows translational regulation upon butanol addition.	Proline	44-51	translation initiation factor eIF2B subunit gamma	Saccharomyces cerevisiae S288C	105-109
11753652-5	2001	Abl was regulated efficiently when its SH3 domain was replaced with a heterologous SH3 from c-Src that binds a different spectrum of proline-rich ligands, but not by substitution of a modular WW domain with similar ligand-binding specificity.	Proline	133-140	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-3
11753652-5	2001	Abl was regulated efficiently when its SH3 domain was replaced with a heterologous SH3 from c-Src that binds a different spectrum of proline-rich ligands, but not by substitution of a modular WW domain with similar ligand-binding specificity.	Proline	133-140	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	92-97
11555637-6	2001	However, gene expression in Escherichia coli and enzymatic analysis showed that the MPR1 gene encodes a novel AZC acetyltransferase, by which L-proline itself and other L-proline analogues are not acetylated.	Proline	142-151	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	84-88
11555637-6	2001	However, gene expression in Escherichia coli and enzymatic analysis showed that the MPR1 gene encodes a novel AZC acetyltransferase, by which L-proline itself and other L-proline analogues are not acetylated.	Proline	169-178	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	84-88
11524424-11	2001	Further studies of Lys-197, Pro-261, and Lys-420, residues conserved in AGPase sequences, by site-directed mutagenesis suggested that the effectors 3-phosphoglyceric acid and P(i) interact at two closely located binding sites.	Proline	28-31	glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic/amyloplastic	Solanum tuberosum	72-78
11697910-4	2001	Considering only the protein-ligand interface, the observed favorable change in standard enthalpy (DeltaH=-9.1 kcal/mol) and unfavorable change in standard entropy (TDeltaS=-2.7 kcal/mol) upon binding the proline-rich ligand RLP2 (RALPPLPRY) are inconsistent with the predominantly hydrophobic interaction surface.	Proline	205-212	Rab interacting lysosomal protein like 2	Homo sapiens	225-229
11518702-6	2001	The binding involves a proline-rich region in pORF3 and the src homology 3 (SH3) domains in the cellular proteins.	Proline	23-30	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	60-63
11707259-0	2001	Both proline-rich sequences in the TH region of Bruton"s tyrosine kinase stabilize intermolecular interactions with the SH3 domain.	Proline	5-12	Bruton tyrosine kinase	Homo sapiens	48-72
11707259-1	2001	The Tec homology (TH) region located N-terminal to the Src homology 3 (SH3) domain of Bruton"s tyrosine kinase (Btk) contains two proline-rich SH3-binding sequences (PRRs).	Proline	130-137	Bruton tyrosine kinase	Homo sapiens	86-110
11707259-1	2001	The Tec homology (TH) region located N-terminal to the Src homology 3 (SH3) domain of Bruton"s tyrosine kinase (Btk) contains two proline-rich SH3-binding sequences (PRRs).	Proline	130-137	Bruton tyrosine kinase	Homo sapiens	112-115
11774038-9	2001	Since the region in Bcl-2 containing serine 70 and serine 87 represents a proline-rich loop that has been associated with autorepression of its antiapoptotic activity, the discovery of Pin1 interactions with phosphorylated Bcl-2 raises the possibility that Pin1 alters the conformation of Bcl-2 and thereby modulates its function in cells arrested with antimicrotubule drugs.	Proline	74-81	BCL2 apoptosis regulator	Homo sapiens	20-25
11689438-3	2001	Proline 155 in C1a is necessary for the recruitment of intact PKD to the TGN.	Proline	0-7	endogenous retrovirus group K member 1	Homo sapiens	15-18
11689438-3	2001	Proline 155 in C1a is necessary for the recruitment of intact PKD to the TGN.	Proline	0-7	protein kinase D1	Homo sapiens	62-65
11604498-8	2001	Furthermore, the CA150 binding site, within the carboxyl-terminal half of SF1, contains a novel type of proline-rich motif that may be recognized by the CA150 WW1 and WW2 domains.	Proline	104-111	transcription elongation regulator 1	Homo sapiens	17-22
11604498-8	2001	Furthermore, the CA150 binding site, within the carboxyl-terminal half of SF1, contains a novel type of proline-rich motif that may be recognized by the CA150 WW1 and WW2 domains.	Proline	104-111	splicing factor 1	Homo sapiens	74-77
11604498-8	2001	Furthermore, the CA150 binding site, within the carboxyl-terminal half of SF1, contains a novel type of proline-rich motif that may be recognized by the CA150 WW1 and WW2 domains.	Proline	104-111	transcription elongation regulator 1	Homo sapiens	153-158
11791870-0	2001	Hb Dartmouth [alpha66(E15)Leu-->Pro (alpha2) (CTG-->CCG)]: a novel alpha2-globin gene mutation associated with severe neonatal anemia when inherited in trans with Southeast Asian alpha-thalassemia-1.	Proline	32-35	glycoprotein hormone subunit alpha 2	Homo sapiens	37-43
11791870-0	2001	Hb Dartmouth [alpha66(E15)Leu-->Pro (alpha2) (CTG-->CCG)]: a novel alpha2-globin gene mutation associated with severe neonatal anemia when inherited in trans with Southeast Asian alpha-thalassemia-1.	Proline	32-35	hemoglobin subunit alpha 2	Homo sapiens	67-80
11791870-1	2001	We report a novel mutation at alpha66(E15)Leu-->Pro (alpha2) (CTG-->CCG), that we have named Hb Dartmouth for the medical center at which the patients were cared for, in monozygotic twins who also inherited the Southeast Asian alpha-thalassemia-1 deletion.	Proline	48-51	glycoprotein hormone subunit alpha 2	Homo sapiens	53-59
11685249-1	2001	C-terminal Src kinase (Csk) takes part in a highly specific, high affinity interaction via its Src homology 3 (SH3) domain with the proline-enriched tyrosine phosphatase PEP in hematopoietic cells.	Proline	132-139	C-terminal Src kinase	Homo sapiens	0-21
11685249-1	2001	C-terminal Src kinase (Csk) takes part in a highly specific, high affinity interaction via its Src homology 3 (SH3) domain with the proline-enriched tyrosine phosphatase PEP in hematopoietic cells.	Proline	132-139	C-terminal Src kinase	Homo sapiens	23-26
11685249-1	2001	C-terminal Src kinase (Csk) takes part in a highly specific, high affinity interaction via its Src homology 3 (SH3) domain with the proline-enriched tyrosine phosphatase PEP in hematopoietic cells.	Proline	132-139	prolyl endopeptidase	Homo sapiens	170-173
11685249-2	2001	The solution structure of the Csk-SH3 domain in complex with a 25-residue peptide from the Pro/Glu/Ser/Thr-rich (PEST) domain of PEP reveals the basis for this specific peptide recognition motif involving an SH3 domain.	Proline	91-94	C-terminal Src kinase	Homo sapiens	30-33
11685249-2	2001	The solution structure of the Csk-SH3 domain in complex with a 25-residue peptide from the Pro/Glu/Ser/Thr-rich (PEST) domain of PEP reveals the basis for this specific peptide recognition motif involving an SH3 domain.	Proline	91-94	prolyl endopeptidase	Homo sapiens	129-132
11685249-3	2001	Three residues, Ala 40, Thr 42 and Lys 43, in the SH3 domain of Csk specifically recognize two hydrophobic residues, Ile 625 and Val 626, in the proline-rich sequence of the PEST domain of PEP.	Proline	145-152	C-terminal Src kinase	Homo sapiens	64-67
11685249-3	2001	Three residues, Ala 40, Thr 42 and Lys 43, in the SH3 domain of Csk specifically recognize two hydrophobic residues, Ile 625 and Val 626, in the proline-rich sequence of the PEST domain of PEP.	Proline	145-152	prolyl endopeptidase	Homo sapiens	189-192
11685249-4	2001	These two residues are C-terminal to the conventional proline-rich SH3 domain recognition sequence of PEP.	Proline	54-61	prolyl endopeptidase	Homo sapiens	102-105
11774038-9	2001	Since the region in Bcl-2 containing serine 70 and serine 87 represents a proline-rich loop that has been associated with autorepression of its antiapoptotic activity, the discovery of Pin1 interactions with phosphorylated Bcl-2 raises the possibility that Pin1 alters the conformation of Bcl-2 and thereby modulates its function in cells arrested with antimicrotubule drugs.	Proline	74-81	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	185-189
11604235-4	2001	Here we show that two proline-juxtaposed serine residues within the transactivation domain of Stat5a are phosphorylated in the mammary gland during late gestation and lactation, and that these phosphorylation sites inhibit the transcriptional activity of Stat5a in the absence of glucocorticoid receptor costimulation.	Proline	22-29	signal transducer and activator of transcription 5A	Homo sapiens	94-100
11517217-8	2001	Systematic dose responses of glycine betaine, glycerol, proline, and trehalose revealed a regulatory effect on the folding activities of individual and combinations of chaperones GroEL, DnaK, and ClpB.	Proline	56-63	GroEL	Escherichia coli	179-184
11604235-4	2001	Here we show that two proline-juxtaposed serine residues within the transactivation domain of Stat5a are phosphorylated in the mammary gland during late gestation and lactation, and that these phosphorylation sites inhibit the transcriptional activity of Stat5a in the absence of glucocorticoid receptor costimulation.	Proline	22-29	signal transducer and activator of transcription 5A	Homo sapiens	255-261
11604235-4	2001	Here we show that two proline-juxtaposed serine residues within the transactivation domain of Stat5a are phosphorylated in the mammary gland during late gestation and lactation, and that these phosphorylation sites inhibit the transcriptional activity of Stat5a in the absence of glucocorticoid receptor costimulation.	Proline	22-29	nuclear receptor subfamily 3 group C member 1	Homo sapiens	280-303
11509578-5	2001	The new protein mainly binds to the proline-rich region of mDia through its Src homology 3 domain and also binds to Grb2 through its proline-rich domain.	Proline	36-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	76-79
11509578-5	2001	The new protein mainly binds to the proline-rich region of mDia through its Src homology 3 domain and also binds to Grb2 through its proline-rich domain.	Proline	36-43	growth factor receptor bound protein 2	Homo sapiens	116-120
11509578-5	2001	The new protein mainly binds to the proline-rich region of mDia through its Src homology 3 domain and also binds to Grb2 through its proline-rich domain.	Proline	133-140	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	76-79
11509578-5	2001	The new protein mainly binds to the proline-rich region of mDia through its Src homology 3 domain and also binds to Grb2 through its proline-rich domain.	Proline	133-140	growth factor receptor bound protein 2	Homo sapiens	116-120
11481323-2	2001	We report the characterization of a new NR coregulator: proline-, glutamic acid-, leucine-rich protein 1 (PELP1), a novel human protein that comprises 1,282 amino acids and is localized on chromosome 17.	Proline	56-63	proline, glutamate and leucine rich protein 1	Homo sapiens	106-111
11598004-4	2001	Other domains of WASp, in particular the proline-rich domain, are required for the formation of actin-rich structures.	Proline	41-48	WASP actin nucleation promoting factor	Homo sapiens	17-21
11598004-5	2001	An in vitro analysis demonstrates that the proline-rich domain of WASp binds VASP with an affinity of approximately 10(6) M(-1).	Proline	43-50	WASP actin nucleation promoting factor	Homo sapiens	66-70
11598004-5	2001	An in vitro analysis demonstrates that the proline-rich domain of WASp binds VASP with an affinity of approximately 10(6) M(-1).	Proline	43-50	vasodilator stimulated phosphoprotein	Homo sapiens	77-81
11495906-10	2001	Of the 20 proline residues in the 5-HT3A receptor subunit only Pro170 has adjacent residues that are favorable.	Proline	10-17	5-hydroxytryptamine receptor 3A	Homo sapiens	34-40
11481323-3	2001	The primary structure of PELP1 consists of several motifs present in most transcriptional regulators including nine NR-interacting boxes (LXXLL motifs), a zinc finger, and glutamic acid- and proline-rich regions.	Proline	191-198	proline, glutamate and leucine rich protein 1	Homo sapiens	25-30
11580293-0	2001	Solution conformation of human apolipoprotein C-1 inferred from proline mutagenesis: far- and near-UV CD study.	Proline	64-71	apolipoprotein C1	Homo sapiens	31-49
11587526-3	2001	Here we show that Bap2p is subject to a starvation-induced degradation upon rapamycin treatment or cultivation with proline as the sole nitrogen source.	Proline	116-123	branched-chain amino acid permease BAP2	Saccharomyces cerevisiae S288C	18-23
11580293-1	2001	Solution structure of lipid-free apolipoprotein C-1 (apoC-1, 6.6 kD) was analyzed by circular dichroism (CD) of 15 mutants containing single Pro or Ala substitutions in predicted alpha-helical regions.	Proline	141-144	apolipoprotein C1	Homo sapiens	33-51
11749778-6	2001	It was observed that TGFbeta1 not only increased the production of FN and [3H]proline incorporation in LLC-PK1 cells (P &lt; 0.01), but also enhanced the mRNA expression of collagen IV and FN.	Proline	78-85	transforming growth factor beta 1	Sus scrofa	21-29
11443120-7	2001	Secretion of AChE(T) was partially restored by co-expression with Q(N), a secretable protein containing a proline-rich attachment domain (PRAD); Q(N) organized PRAD-linked tetramers, except for the N-glycosylated mutants.	Proline	106-113	acetylcholinesterase	Rattus norvegicus	13-17
11696660-3	2001	A recent study indicated that the NPY gene variant producing a leucine-to-proline substitution (T to C at position 1128) was associated with 34% higher average alcohol consumption.	Proline	74-81	neuropeptide Y	Homo sapiens	34-37
11696660-7	2001	CONCLUSIONS: We speculate that the genetic polymorphism producing the proline(7) substitution of NPY might not predispose to alcoholism, but indeed retard the transition to alcoholism.	Proline	70-77	neuropeptide Y	Homo sapiens	97-100
11592063-7	2001	We showed that LAP binds specifically in vitro and in vivo to the Glu-Pro (EP) repeated motif present in the LAG-3 intracytoplasmic region.	Proline	70-73	LAP	Homo sapiens	15-18
12168769-0	2001	CAMP-dependent protein kinase inhibits proline transport across the rat renal tubular brush border membrane.	Proline	39-46	cyclin-dependent kinase 7	Rattus norvegicus	0-29
12168769-7	2001	cAMP, by activating endogenous cAK,and exogenous, highly purified catalytic subunit of cAK inhibited NaCl-dependent proline transport by phosphorylated, lysed/resealed BBMV compared with control vesicles.	Proline	116-123	cyclin-dependent kinase 7	Rattus norvegicus	87-90
12168769-8	2001	The cAK-mediated inhibition of proline uptake was completely abolished when phosphorylation at the cytoplasmic (inner side) of the membrane was prevented by isosmotic, rather than hyposmotic, phosphorylation.	Proline	31-38	cyclin-dependent kinase 7	Rattus norvegicus	4-7
12168769-9	2001	The cAK-induced inhibition of proline transport was reversed by the specific cAK inhibitor peptide, PK1.	Proline	30-37	cyclin-dependent kinase 7	Rattus norvegicus	4-7
12168769-9	2001	The cAK-induced inhibition of proline transport was reversed by the specific cAK inhibitor peptide, PK1.	Proline	30-37	cyclin-dependent kinase 7	Rattus norvegicus	77-80
12168769-9	2001	The cAK-induced inhibition of proline transport was reversed by the specific cAK inhibitor peptide, PK1.	Proline	30-37	pyruvate kinase L/R	Rattus norvegicus	100-103
12168769-10	2001	These data suggest that cAMP-dependent protein kinase-mediated phosphorylation modulates Na+(-) and Cl(-)-linked proline transport across the tubular luminal membrane.	Proline	113-120	cyclin-dependent kinase 7	Rattus norvegicus	24-53
11592063-7	2001	We showed that LAP binds specifically in vitro and in vivo to the Glu-Pro (EP) repeated motif present in the LAG-3 intracytoplasmic region.	Proline	70-73	lymphocyte activating 3	Homo sapiens	109-114
11581171-2	2001	The Itk-SH3 domain and the Rch1alpha proline-rich (PR) motif were crucial for the Itk/Rch1alpha constitutive interaction as demonstrated by directed mutagenesis of the Rch1alpha PR motif (proline 242 to alanine, P242A).	Proline	37-44	IL2 inducible T cell kinase	Homo sapiens	82-85
11533253-3	2001	In this study the interaction between PI3K-C2beta and the EGF receptor is competitively attenuated by synthetic peptides derived from each of three proline-rich motifs present within the N-terminal region of the PI3K.	Proline	148-155	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	Homo sapiens	38-49
11562779-7	2001	The HLA DQB1*0501 peptide ligand sequence showed that proline gives an outstanding signal at position 2, Asn/Arg at P1, aliphatic/aromatic amino acids in the central portion, a hydrophobic cluster at P5 with a small contribution by small polar residues and another cluster of aromatic residues towards the C-terminus.	Proline	54-61	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	4-12
11562779-8	2001	The HLA DQB1*0301 sequence also showed that proline gives an outstanding signal at position 2, Thr/Arg at P1, aliphatic/aromatic amino acids in the central portion and an aliphatic cluster with a small contribution by small polar residues at P5.	Proline	44-51	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	4-12
11559796-5	2001	Duplication of the proline-rich p6(Gag) PTAP motif, necessary for late viral cycle activities, was identified in plasma virus from 47 of 222 (21.2%) patients treated with nucleoside analog RT inhibitor (NRTI) antiretroviral therapy but was identified very rarely from drug-naive individuals.	Proline	19-26	S100 calcium binding protein A12	Homo sapiens	32-39
11533253-3	2001	In this study the interaction between PI3K-C2beta and the EGF receptor is competitively attenuated by synthetic peptides derived from each of three proline-rich motifs present within the N-terminal region of the PI3K.	Proline	148-155	epidermal growth factor	Homo sapiens	58-61
11533253-4	2001	Further, a series of N-terminal PI3K-C2beta fragments, truncated prior to each proline-rich region, bound the receptor with decreased efficiency.	Proline	79-86	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	Homo sapiens	32-43
11533253-6	2001	Finally, an equivalent N-terminal fragment of PI3K-C2alpha that lacks similar proline-rich motifs was unable to affinity purify the activated EGF receptor from cell lysates.	Proline	78-85	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	46-58
11533253-13	2001	We conclude that proline-rich motifs within the N terminus of PI3K-C2beta mediate the association of this enzyme with activated EGF receptor and that this interaction involves the Grb2 adaptor.	Proline	17-24	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	Homo sapiens	62-73
11679068-5	2001	Fba, a 37.8 kDa protein, possesses three or four proline-rich repeat domains and exhibits a high homology to FnBPA, the Fn-binding protein of Staphylococcus aureus.	Proline	49-56	F-box protein 3	Mus musculus	0-3
11533253-13	2001	We conclude that proline-rich motifs within the N terminus of PI3K-C2beta mediate the association of this enzyme with activated EGF receptor and that this interaction involves the Grb2 adaptor.	Proline	17-24	epidermal growth factor	Homo sapiens	128-131
11533253-13	2001	We conclude that proline-rich motifs within the N terminus of PI3K-C2beta mediate the association of this enzyme with activated EGF receptor and that this interaction involves the Grb2 adaptor.	Proline	17-24	growth factor receptor bound protein 2	Homo sapiens	180-184
11463790-10	2001	The substitutions of Thr(297) in GRPR by Pro from the comparable position in NMBR, Phe(302) by Met, and Ser(305) by Thr decreased the affinity of each antagonist.	Proline	41-44	gastrin releasing peptide receptor	Homo sapiens	33-37
11564578-1	2001	The p53 codon 72 polymorphism, resulting in either an arginine or a proline residue has been proposed to affect the susceptibility of p53 protein to human papilloma virus (HPV) E6-mediated degradation in vitro.	Proline	68-75	tumor protein p53	Homo sapiens	4-7
11564578-1	2001	The p53 codon 72 polymorphism, resulting in either an arginine or a proline residue has been proposed to affect the susceptibility of p53 protein to human papilloma virus (HPV) E6-mediated degradation in vitro.	Proline	68-75	tumor protein p53	Homo sapiens	134-137
11574675-2	2001	PNRC2 is an unusual coactivator in that it is the smallest coactivator identified so far, with a molecular weight of 16 kDa, and interacts with nuclear receptors using a proline-rich sequence.	Proline	170-177	proline rich nuclear receptor coactivator 2	Homo sapiens	0-5
11561288-7	2001	Like Pbs2p, this protein also has a proline-rich motif.	Proline	36-43	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	5-10
11575923-7	2001	These domains contain numerous serine-proline and threonine-proline residues similar to those found in the carboxyl-terminal domain (CTD) of Rpb1.	Proline	38-45	RNA polymerase II subunit A	Homo sapiens	141-145
11425863-8	2001	CK14 failed to bind to ATMP when the third proline was substituted with threonine, as in some cases of human X-linked amelogenesis imperfecta or when tyrosyl residues were substituted with phenylalanine.	Proline	43-50	keratin 14	Homo sapiens	0-4
11575923-7	2001	These domains contain numerous serine-proline and threonine-proline residues similar to those found in the carboxyl-terminal domain (CTD) of Rpb1.	Proline	60-67	RNA polymerase II subunit A	Homo sapiens	141-145
11566872-2	2001	We have introduced a specific mutation into the endogenous murine PrP gene using gene targeting to produce transgenic mice with a single amino acid alteration (proline to leucine) at amino acid position 101 in their PrP protein (P101L).	Proline	160-167	prion protein	Mus musculus	66-69
11463797-5	2001	However, some other tyrosine(s), as well as the Src homology (SH) 2 domain and the two proline-rich regions in MIST, is still required for full reconstitution of the BCR signaling, in cooperation with LAT.	Proline	87-94	BCR activator of RhoGEF and GTPase	Gallus gallus	166-169
11463797-7	2001	On the other hand, the N-terminal proline-rich region, which is a binding site of the SH3 domain of phospholipase Cgamma, is essential for BCR signaling.	Proline	34-41	BCR activator of RhoGEF and GTPase	Gallus gallus	139-142
11566872-2	2001	We have introduced a specific mutation into the endogenous murine PrP gene using gene targeting to produce transgenic mice with a single amino acid alteration (proline to leucine) at amino acid position 101 in their PrP protein (P101L).	Proline	160-167	prion protein	Mus musculus	216-219
11395501-4	2001	The N-terminal proline-rich region of zyxin, which harbors binding sites for alpha-actinin and members of the Ena/VASP family, concentrates in lamellipodial extensions and weakly in focal adhesions.	Proline	15-22	zyxin	Homo sapiens	38-43
11395501-4	2001	The N-terminal proline-rich region of zyxin, which harbors binding sites for alpha-actinin and members of the Ena/VASP family, concentrates in lamellipodial extensions and weakly in focal adhesions.	Proline	15-22	actinin alpha 1	Homo sapiens	77-90
11443109-0	2001	Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro.	Proline	63-70	transglutaminase 5	Homo sapiens	0-18
11431473-2	2001	The protein was named RICH-1 (RhoGAP interacting with CIP4 homologues), and, in addition to the RhoGAP domain, it contained an N-terminal domain with endophilin homology and a C-terminal proline-rich domain.	Proline	187-194	Rho GTPase activating protein 17	Homo sapiens	22-28
11431473-2	2001	The protein was named RICH-1 (RhoGAP interacting with CIP4 homologues), and, in addition to the RhoGAP domain, it contained an N-terminal domain with endophilin homology and a C-terminal proline-rich domain.	Proline	187-194	Rho GTPase activating protein 1	Homo sapiens	30-36
11431473-2	2001	The protein was named RICH-1 (RhoGAP interacting with CIP4 homologues), and, in addition to the RhoGAP domain, it contained an N-terminal domain with endophilin homology and a C-terminal proline-rich domain.	Proline	187-194	thyroid hormone receptor interactor 10	Homo sapiens	54-58
11395479-5	2001	CDA1 comprises an N-terminal proline-rich domain, a central basic domain, and a C-terminal bipartite acidic domain.	Proline	29-36	TSPY like 2	Homo sapiens	0-4
11524020-1	2001	The structure and folding of a novel human insulin mutant, [Thr(B27) --&gt; Pro, Pro(B28) --&gt; Thr]insulin (PT insulin), in aqueous solution and in mixtures of water and 2,2,2-trifluoroethanol (TFE) have been studied by NMR spectroscopy.	Proline	76-79	insulin	Homo sapiens	43-50
11571642-0	2001	p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress.	Proline	67-74	tumor protein p53	Homo sapiens	0-3
11571642-0	2001	p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress.	Proline	67-74	tumor protein p53	Homo sapiens	90-93
11571642-7	2001	However, the proline-rich domain towards the N-terminus of p53 (residues 67 to 98) appeared important for binding to the nuclear matrix.	Proline	13-20	tumor protein p53	Homo sapiens	59-62
11571642-9	2001	The proline-rich domain of p53 has potential for SH3 protein-protein interaction, and has a role in p53-mediated apoptosis and possibly base excision repair of DNA damage.	Proline	4-11	tumor protein p53	Homo sapiens	27-30
11571642-9	2001	The proline-rich domain of p53 has potential for SH3 protein-protein interaction, and has a role in p53-mediated apoptosis and possibly base excision repair of DNA damage.	Proline	4-11	tumor protein p53	Homo sapiens	100-103
11524020-1	2001	The structure and folding of a novel human insulin mutant, [Thr(B27) --&gt; Pro, Pro(B28) --&gt; Thr]insulin (PT insulin), in aqueous solution and in mixtures of water and 2,2,2-trifluoroethanol (TFE) have been studied by NMR spectroscopy.	Proline	76-79	insulin	Homo sapiens	101-108
11550225-5	2001	Hyperosmotic stress also resulted in a robust increase in tau phosphorylation at both Ser/Pro and non-Ser/Pro sites.	Proline	90-93	microtubule associated protein tau	Homo sapiens	58-61
11550225-5	2001	Hyperosmotic stress also resulted in a robust increase in tau phosphorylation at both Ser/Pro and non-Ser/Pro sites.	Proline	106-109	microtubule associated protein tau	Homo sapiens	58-61
11524020-1	2001	The structure and folding of a novel human insulin mutant, [Thr(B27) --&gt; Pro, Pro(B28) --&gt; Thr]insulin (PT insulin), in aqueous solution and in mixtures of water and 2,2,2-trifluoroethanol (TFE) have been studied by NMR spectroscopy.	Proline	81-84	insulin	Homo sapiens	43-50
11524020-1	2001	The structure and folding of a novel human insulin mutant, [Thr(B27) --&gt; Pro, Pro(B28) --&gt; Thr]insulin (PT insulin), in aqueous solution and in mixtures of water and 2,2,2-trifluoroethanol (TFE) have been studied by NMR spectroscopy.	Proline	81-84	insulin	Homo sapiens	101-108
11675932-1	2001	Drebrin, an actin-binding 70-kDa protein with an unusually slow SDS-PAGE mobility corresponding to approximately 120 kDa, containing a proline-rich, profilin-binding motif, had originally been reported from neuronal cells, but recently has also been found in diverse other kinds of tissues and cell lines.	Proline	135-142	drebrin 1	Homo sapiens	0-7
11680815-0	2001	Cytotoxicity and effect on collagen biosynthesis of proline analogue of melphalan as a prolidase-convertible prodrug in cultured human skin fibroblasts.	Proline	52-59	peptidase D	Homo sapiens	87-96
11680815-1	2001	Proline analogue of melphalan (MEL-PRO) was synthesised as a prodrug susceptible to the action of ubiquitously distributed, cytosolic imidodipeptidase--prolidase [E.C.3.4.13.9].	Proline	0-7	peptidase D	Homo sapiens	152-161
11562118-4	2001	AdBMP-7 modification of bovine chondrocytes induced expression of BMP-7 mRNA and bioactive protein, resulting in an increase in incorporation of 35SO4- into proteoglycan, 3H-proline uptake into protein, and the expression of the cartilage-specific matrix genes, aggrecan and type II collagen.	Proline	174-181	bone morphogenetic protein 7	Bos taurus	2-7
11680815-2	2001	Conjugation of melphalan (MEL) with proline (PRO) through an imido-bond resulted in formation of a good substrate for prolidase.	Proline	36-43	peptidase D	Homo sapiens	118-127
11680815-2	2001	Conjugation of melphalan (MEL) with proline (PRO) through an imido-bond resulted in formation of a good substrate for prolidase.	Proline	45-48	peptidase D	Homo sapiens	118-127
11557193-2	2001	The production of TGF-beta1 is genetically controlled as polymorphisms in the signaling sequence of the TGF-beta1 gene leucine(10)--&gt;proline and arginine(25)--&gt;proline are involved in the regulation of the protein production level.	Proline	136-143	transforming growth factor beta 1	Homo sapiens	18-27
11557193-2	2001	The production of TGF-beta1 is genetically controlled as polymorphisms in the signaling sequence of the TGF-beta1 gene leucine(10)--&gt;proline and arginine(25)--&gt;proline are involved in the regulation of the protein production level.	Proline	136-143	transforming growth factor beta 1	Homo sapiens	104-113
11557193-2	2001	The production of TGF-beta1 is genetically controlled as polymorphisms in the signaling sequence of the TGF-beta1 gene leucine(10)--&gt;proline and arginine(25)--&gt;proline are involved in the regulation of the protein production level.	Proline	166-173	transforming growth factor beta 1	Homo sapiens	18-27
11557193-2	2001	The production of TGF-beta1 is genetically controlled as polymorphisms in the signaling sequence of the TGF-beta1 gene leucine(10)--&gt;proline and arginine(25)--&gt;proline are involved in the regulation of the protein production level.	Proline	166-173	transforming growth factor beta 1	Homo sapiens	104-113
11592597-4	2001	RESULTS: Differentially expressed cDNA products were identified with about 92% homology to genes coding for mouse proline rich protein expressed in brain (PRTB), rat clusterin, elongin, and human Kelch motif containing protein.	Proline	114-121	DAZ associated protein 2	Mus musculus	155-159
11592597-4	2001	RESULTS: Differentially expressed cDNA products were identified with about 92% homology to genes coding for mouse proline rich protein expressed in brain (PRTB), rat clusterin, elongin, and human Kelch motif containing protein.	Proline	114-121	kelch like family member 20	Homo sapiens	196-226
11543766-1	2001	A nonapeptide derived from the C terminus of the insulin B chain, H(2)N-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala-COOH, was found to strongly inhibit dopamine (DA) uptake by rat dopamine transporter (DAT) stably expressed in CHO cells (designated D8 cells).	Proline	96-100	solute carrier family 6 member 3	Rattus norvegicus	172-192
11684295-5	2001	Interestingly, bovine IgM has the lowest number of proline residues (5) in the Cmu2 domain in comparison to other species (7-9) and this is likely to impose structural constraints on mobility of Fab arms of the bovine IgM during antigen recognition.	Proline	51-58	IgM	Bos taurus	22-25
11684295-5	2001	Interestingly, bovine IgM has the lowest number of proline residues (5) in the Cmu2 domain in comparison to other species (7-9) and this is likely to impose structural constraints on mobility of Fab arms of the bovine IgM during antigen recognition.	Proline	51-58	IgM	Bos taurus	218-221
11533658-1	2001	Phosphorylation on a serine or threonine residue preceding proline (Ser/Thr-Pro) is a key regulatory mechanism, and the conformation of certain phosphorylated Ser/Thr-Pro bonds is regulated specifically by the prolyl isomerase Pin1.	Proline	76-79	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	227-231
11550977-4	2001	RESULTS: GM-CSF (6-100 U/ml) inhibited (30%) [3H]-thymidine incorporation into DNA, and, in contrast, stimulated up to 3.6- and 2-fold [35S]SO4 and [3H]-proline incorporation into glycosaminoglycan side chains and collagen molecules, respectively.	Proline	153-160	colony stimulating factor 2	Rattus norvegicus	9-15
11543766-1	2001	A nonapeptide derived from the C terminus of the insulin B chain, H(2)N-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala-COOH, was found to strongly inhibit dopamine (DA) uptake by rat dopamine transporter (DAT) stably expressed in CHO cells (designated D8 cells).	Proline	96-100	solute carrier family 6 member 3	Rattus norvegicus	194-197
11513868-0	2001	Functional roles of conserved transmembrane prolines in the human VPAC(1) receptor.	Proline	44-52	vasoactive intestinal peptide receptor 1	Homo sapiens	66-82
11514016-1	2001	Inspection of the amino acid sequence of the human VPAC1 and the VPAC2 receptors after alignment of the conserved residues indicates that the second extracellular loop (EC2) is one amino acid shorter in the VPAC1 receptor due to the lack of a proline residue in position 294.	Proline	243-250	transcription factor 15	Homo sapiens	169-172
11514016-3	2001	Insertion by directed mutagenesis of a proline in that position (&lt;Pro&gt;294 VPAC1) had little consequence on the binding of several agonists but reduced the affinity for the VPAC1 antagonist.	Proline	39-46	vasoactive intestinal peptide receptor 1	Homo sapiens	80-85
11514016-3	2001	Insertion by directed mutagenesis of a proline in that position (&lt;Pro&gt;294 VPAC1) had little consequence on the binding of several agonists but reduced the affinity for the VPAC1 antagonist.	Proline	39-46	vasoactive intestinal peptide receptor 1	Homo sapiens	178-183
11514016-5	2001	Deletion of the proline 280 (DeltaPro280 VPAC2) in the VPAC2 receptor markedly reduced the apparent affinity for all the agonists tested.	Proline	16-23	vasoactive intestinal peptide receptor 2	Homo sapiens	41-46
11514016-5	2001	Deletion of the proline 280 (DeltaPro280 VPAC2) in the VPAC2 receptor markedly reduced the apparent affinity for all the agonists tested.	Proline	16-23	vasoactive intestinal peptide receptor 2	Homo sapiens	55-60
11514016-7	2001	The proline residue in the VPAC2 receptor EC2 is thus essential for the receptor structure, and the EC2 domain is involved in ligand recognition and receptor functionality.	Proline	4-11	vasoactive intestinal peptide receptor 2	Homo sapiens	27-32
11514016-7	2001	The proline residue in the VPAC2 receptor EC2 is thus essential for the receptor structure, and the EC2 domain is involved in ligand recognition and receptor functionality.	Proline	4-11	transcription factor 15	Homo sapiens	42-45
11514016-0	2001	Proline residue 280 in the second extracellular loop (EC2) of the VPAC2 receptor is essential for the receptor structure.	Proline	0-7	transcription factor 15	Homo sapiens	54-57
11514016-0	2001	Proline residue 280 in the second extracellular loop (EC2) of the VPAC2 receptor is essential for the receptor structure.	Proline	0-7	vasoactive intestinal peptide receptor 2	Homo sapiens	66-71
11678272-5	2001	MBP2 contains a region of high content of proline and alanine residues, commonly found in arabinogalactan proteins and hydroxyproline-rich glycoproteins.	Proline	42-49	myrosinase-binding protein 2	Arabidopsis thaliana	0-4
11432849-2	2001	PS is an evolutionarily conserved multipass transmembrane protein, and all known PS proteins contain a proline-alanine-leucine-proline (PALP) motif starting at proline (P) 414 (amino acid numbering based on human PS2) at the C terminus.	Proline	103-110	presenilin 2	Homo sapiens	213-216
11513868-1	2001	The importance of three conserved transmembrane prolines of the human vasoactive intestinal polypeptide (VPAC)(1) receptor was examined by single alanine substitution.	Proline	48-56	vasoactive intestinal peptide receptor 1	Homo sapiens	70-122
11485551-10	2001	Furthermore, interaction with proline-rich binding partners might also contribute to regulating profilin"s effect on actin assembly in plant cells.	Proline	30-37	profilin-4	Zea mays	96-104
11402029-3	2001	Comparison of the amino acid sequences of the Cdc7 regulatory subunits from various eukaryotes revealed the presence of three small stretches of conserved amino acid sequences, namely Dbf4 motifs N, M, and C. We report here that the Dbf4 motif M, a unique proline-rich motif, and the Dbf4 motif C, a C(2)H(2)-type zinc finger motif, are essential for mitotic functions of Dfp1/Him1 protein as well as for full-level activation of Hsk1 kinase.	Proline	256-263	serine/threonine protein kinase CDC7	Saccharomyces cerevisiae S288C	46-50
11402029-3	2001	Comparison of the amino acid sequences of the Cdc7 regulatory subunits from various eukaryotes revealed the presence of three small stretches of conserved amino acid sequences, namely Dbf4 motifs N, M, and C. We report here that the Dbf4 motif M, a unique proline-rich motif, and the Dbf4 motif C, a C(2)H(2)-type zinc finger motif, are essential for mitotic functions of Dfp1/Him1 protein as well as for full-level activation of Hsk1 kinase.	Proline	256-263	protein serine/threonine kinase activating protein DBF4	Saccharomyces cerevisiae S288C	184-188
11402029-3	2001	Comparison of the amino acid sequences of the Cdc7 regulatory subunits from various eukaryotes revealed the presence of three small stretches of conserved amino acid sequences, namely Dbf4 motifs N, M, and C. We report here that the Dbf4 motif M, a unique proline-rich motif, and the Dbf4 motif C, a C(2)H(2)-type zinc finger motif, are essential for mitotic functions of Dfp1/Him1 protein as well as for full-level activation of Hsk1 kinase.	Proline	256-263	protein serine/threonine kinase activating protein DBF4	Saccharomyces cerevisiae S288C	233-237
11402029-3	2001	Comparison of the amino acid sequences of the Cdc7 regulatory subunits from various eukaryotes revealed the presence of three small stretches of conserved amino acid sequences, namely Dbf4 motifs N, M, and C. We report here that the Dbf4 motif M, a unique proline-rich motif, and the Dbf4 motif C, a C(2)H(2)-type zinc finger motif, are essential for mitotic functions of Dfp1/Him1 protein as well as for full-level activation of Hsk1 kinase.	Proline	256-263	protein serine/threonine kinase activating protein DBF4	Saccharomyces cerevisiae S288C	233-237
11525746-0	2001	A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.	Proline	29-36	Nef	Human immunodeficiency virus 1	51-54
11525746-4	2001	Here, we report that a natural variability in the proline-rich motif (R71T) profoundly modulated Nef-stimulated viral replication in primary T cells of immature dendritic cell/T cell cocultures.	Proline	50-57	S100 calcium binding protein B	Homo sapiens	97-100
11387320-0	2001	Deletion of the Src homology 3 domain and C-terminal proline-rich sequences in Bcr-Abl prevents Abl interactor 2 degradation and spontaneous cell migration and impairs leukemogenesis.	Proline	53-60	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	79-86
11356843-9	2001	CAN1, DAL4, DAL5, MEP2, DAL1, DAL80, and GDH3 transcription is down-regulated by Vid30p function with proline as the nitrogen source.	Proline	102-109	arginine permease CAN1	Saccharomyces cerevisiae S288C	0-4
11356843-9	2001	CAN1, DAL4, DAL5, MEP2, DAL1, DAL80, and GDH3 transcription is down-regulated by Vid30p function with proline as the nitrogen source.	Proline	102-109	allantoin permease	Saccharomyces cerevisiae S288C	6-10
11356843-9	2001	CAN1, DAL4, DAL5, MEP2, DAL1, DAL80, and GDH3 transcription is down-regulated by Vid30p function with proline as the nitrogen source.	Proline	102-109	allantoate permease	Saccharomyces cerevisiae S288C	12-16
11356843-9	2001	CAN1, DAL4, DAL5, MEP2, DAL1, DAL80, and GDH3 transcription is down-regulated by Vid30p function with proline as the nitrogen source.	Proline	102-109	ammonium permease MEP2	Saccharomyces cerevisiae S288C	18-22
11356843-9	2001	CAN1, DAL4, DAL5, MEP2, DAL1, DAL80, and GDH3 transcription is down-regulated by Vid30p function with proline as the nitrogen source.	Proline	102-109	allantoinase	Saccharomyces cerevisiae S288C	24-28
11387320-0	2001	Deletion of the Src homology 3 domain and C-terminal proline-rich sequences in Bcr-Abl prevents Abl interactor 2 degradation and spontaneous cell migration and impairs leukemogenesis.	Proline	53-60	abl interactor 2	Homo sapiens	96-112
11356843-9	2001	CAN1, DAL4, DAL5, MEP2, DAL1, DAL80, and GDH3 transcription is down-regulated by Vid30p function with proline as the nitrogen source.	Proline	102-109	Dal80p	Saccharomyces cerevisiae S288C	30-35
11387320-5	2001	We report here that the Src homology 3 domain and C-terminal proline-rich sequences of Bcr-Abl are required for its binding to Abl interactor 2 as well as for the induction of Abl interactor 2 degradation.	Proline	61-68	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	87-94
11356843-9	2001	CAN1, DAL4, DAL5, MEP2, DAL1, DAL80, and GDH3 transcription is down-regulated by Vid30p function with proline as the nitrogen source.	Proline	102-109	glutamate dehydrogenase (NADP(+)) GDH3	Saccharomyces cerevisiae S288C	41-45
11356843-9	2001	CAN1, DAL4, DAL5, MEP2, DAL1, DAL80, and GDH3 transcription is down-regulated by Vid30p function with proline as the nitrogen source.	Proline	102-109	glucose-induced degradation complex subunit VID30	Saccharomyces cerevisiae S288C	81-87
11387320-5	2001	We report here that the Src homology 3 domain and C-terminal proline-rich sequences of Bcr-Abl are required for its binding to Abl interactor 2 as well as for the induction of Abl interactor 2 degradation.	Proline	61-68	abl interactor 2	Homo sapiens	127-143
11387320-5	2001	We report here that the Src homology 3 domain and C-terminal proline-rich sequences of Bcr-Abl are required for its binding to Abl interactor 2 as well as for the induction of Abl interactor 2 degradation.	Proline	61-68	abl interactor 2	Homo sapiens	176-192
11468184-2	2001	Although p12(I) contains 4 minimal proline-rich, src homology 3-binding motifs (PXXP), a characteristic commonly found in proteins involved in signaling pathways, it has not been known whether p12(I) has a role in modulating intracellular signaling pathways.	Proline	35-42	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	9-12
11390389-2	2001	PLSCR1 contains multiple proline-rich motifs resembling Src homology 3 (SH3) domain-binding sites.	Proline	25-32	phospholipid scramblase 1	Mus musculus	0-6
11390389-5	2001	Deletion of the proline-rich segment in PLSCR1 (residues 1--118) abolished its binding to the Abl SH3 domain.	Proline	16-23	phospholipid scramblase 1	Mus musculus	40-46
11390389-5	2001	Deletion of the proline-rich segment in PLSCR1 (residues 1--118) abolished its binding to the Abl SH3 domain.	Proline	16-23	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	94-97
11389867-1	2001	A proline-specific dipeptidyl aminopeptidase, dipeptidyl peptidase IV (EC 3.4.14.5), was purified from a cell sonicate soluble fraction of Prevotella loescheii ATCC 15930 by sequential column chromatography.	Proline	2-9	dipeptidyl peptidase 4	Homo sapiens	46-69
11504942-0	2001	HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.	Proline	61-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
11504942-0	2001	HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.	Proline	61-68	von Hippel-Lindau tumor suppressor	Homo sapiens	22-25
11504942-7	2001	The data furthermore show that this proline hydroxylation is the primary regulator of VHL binding.	Proline	36-43	von Hippel-Lindau tumor suppressor	Homo sapiens	86-89
11433529-8	2001	A reciprocal LPP-MLL transcript, predicted to include the proline-rich and leucine zipper motifs, and the first LIM domain of LPP were also detected by RT-PCR.	Proline	58-65	LIM domain containing preferred translocation partner in lipoma	Homo sapiens	13-16
11461120-6	2001	In addition stimulation with MIP-1alpha induces tyrosine phosphorylation of the proline-rich tyrosine kinase Pyk-2.	Proline	80-87	C-C motif chemokine ligand 3	Homo sapiens	29-39
11461120-6	2001	In addition stimulation with MIP-1alpha induces tyrosine phosphorylation of the proline-rich tyrosine kinase Pyk-2.	Proline	80-87	protein tyrosine kinase 2 beta	Homo sapiens	109-114
11433529-8	2001	A reciprocal LPP-MLL transcript, predicted to include the proline-rich and leucine zipper motifs, and the first LIM domain of LPP were also detected by RT-PCR.	Proline	58-65	lysine methyltransferase 2A	Homo sapiens	17-20
11514617-8	2001	Expression of the Cas-binding proline-rich region 1 of FAK hindered association of Cas with FAK and impaired the structural stability of sarcomeres.	Proline	30-37	protein tyrosine kinase 2	Homo sapiens	55-58
11502839-6	2001	One patient was found to harbor a heterozygous transversion 119A--&gt;C in exon 3 of PAX8 replacing a conserved glutamine by proline in the paired box domain (Q40P).	Proline	125-132	paired box 8	Homo sapiens	85-89
11697487-8	2001	The AF3p21 gene encodes a nuclear protein with a molecular mass of 80 kDa, and this protein has SH3 and proline-rich domains.	Proline	104-111	NCK interacting protein with SH3 domain	Homo sapiens	4-10
11545730-0	2001	Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases.	Proline	33-40	progesterone receptor	Homo sapiens	0-21
11520460-5	2001	Surprisingly, WASP localization was independent of the Cdc42 binding domain but required the proline-rich domain.	Proline	93-100	WASP actin nucleation promoting factor	Homo sapiens	14-18
11458008-6	2001	ORFs 3 and 4 are located at the extreme 3" end of the viral genome and encode proline-rich proteins of 31.4 kDa (p31) and 15.9 kDa (p16), respectively, of unknown function.	Proline	78-85	ATPase H+ transporting V1 subunit E1	Homo sapiens	113-116
11523086-10	2001	The presence of two highly basic arginine residues on bradykinin results in its high GB(app), while the basicity of des-Arg1-bradykinin ions is increased by the presence of two proline residues at the N-terminus.	Proline	177-184	kininogen 1	Homo sapiens	54-64
11523086-10	2001	The presence of two highly basic arginine residues on bradykinin results in its high GB(app), while the basicity of des-Arg1-bradykinin ions is increased by the presence of two proline residues at the N-terminus.	Proline	177-184	arginase 1	Homo sapiens	120-124
11523086-10	2001	The presence of two highly basic arginine residues on bradykinin results in its high GB(app), while the basicity of des-Arg1-bradykinin ions is increased by the presence of two proline residues at the N-terminus.	Proline	177-184	kininogen 1	Homo sapiens	125-135
11580269-4	2001	When two evolutionarily highly conserved glycine residues of beta-actin, G146 and G150, were changed to proline, both mutant actin proteins were poorly processed by CCT in in vitro translation assays; they become arrested on CCT.	Proline	104-111	CCT	Homo sapiens	165-168
11580269-4	2001	When two evolutionarily highly conserved glycine residues of beta-actin, G146 and G150, were changed to proline, both mutant actin proteins were poorly processed by CCT in in vitro translation assays; they become arrested on CCT.	Proline	104-111	CCT	Homo sapiens	225-228
11545730-0	2001	Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases.	Proline	33-40	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	107-112
11514617-8	2001	Expression of the Cas-binding proline-rich region 1 of FAK hindered association of Cas with FAK and impaired the structural stability of sarcomeres.	Proline	30-37	protein tyrosine kinase 2	Homo sapiens	92-95
11514617-10	2001	Moreover, expression of the focal adhesion-targeting and/or the Cas-binding proline-rich regions of FAK inhibited ANP promoter activity and suppressed ET-induced ANP and brain natriuretic peptide gene expression.	Proline	76-83	protein tyrosine kinase 2	Homo sapiens	100-103
11514617-10	2001	Moreover, expression of the focal adhesion-targeting and/or the Cas-binding proline-rich regions of FAK inhibited ANP promoter activity and suppressed ET-induced ANP and brain natriuretic peptide gene expression.	Proline	76-83	natriuretic peptide A	Homo sapiens	114-117
11514617-10	2001	Moreover, expression of the focal adhesion-targeting and/or the Cas-binding proline-rich regions of FAK inhibited ANP promoter activity and suppressed ET-induced ANP and brain natriuretic peptide gene expression.	Proline	76-83	natriuretic peptide A	Homo sapiens	162-165
11500568-4	2001	Leucine-534 and proline-535 present in hGSHS were substituted by alanines that are conserved in plant GSHS.	Proline	16-23	glutathione synthetase	Homo sapiens	39-44
11500568-4	2001	Leucine-534 and proline-535 present in hGSHS were substituted by alanines that are conserved in plant GSHS.	Proline	16-23	glutathione synthetase	Homo sapiens	40-44
11493738-2	2001	In D category V types I and II, the amino acid at position 226 is alanine, which is typical of the prevalent RHD allele and is observed in all RHCE alleles encoding the antigen e. A proline at position 226 in RHCE encodes the antigen E. STUDY DESIGN AND METHODS: A blood sample of ccDEe phenotype was referred as suspected D category VI.	Proline	182-189	Rh blood group D antigen	Homo sapiens	109-112
11532179-4	2001	The N-terminus of p44 contains a degradation motif characterized by proline, glutamate, aspartate, serine and threonine residues (PEST), which can be inactivated by mutation of three glutamic acid residues to alanines.	Proline	68-75	interferon induced protein 44	Homo sapiens	18-21
11532180-1	2001	Delta1-pyrroline-5-carboxylate (P5C), an intermediate in biosynthesis and degradation of proline (Pro), is assumed to play a role in cell death in plants and animals.	Proline	89-96	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-30
11532180-1	2001	Delta1-pyrroline-5-carboxylate (P5C), an intermediate in biosynthesis and degradation of proline (Pro), is assumed to play a role in cell death in plants and animals.	Proline	89-96	pyrroline-5-carboxylate reductase 1	Homo sapiens	32-35
11532180-1	2001	Delta1-pyrroline-5-carboxylate (P5C), an intermediate in biosynthesis and degradation of proline (Pro), is assumed to play a role in cell death in plants and animals.	Proline	98-101	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-30
11532180-1	2001	Delta1-pyrroline-5-carboxylate (P5C), an intermediate in biosynthesis and degradation of proline (Pro), is assumed to play a role in cell death in plants and animals.	Proline	98-101	pyrroline-5-carboxylate reductase 1	Homo sapiens	32-35
11532180-2	2001	Toxicity of external Pro and P5C supply to Arabidopsis suggested that P5C dehydrogenase (P5CDH; EC 1.2.1.12) plays a crucial role in this process by degrading the toxic Pro catabolism intermediate P5C.	Proline	21-24	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	70-87
11532180-2	2001	Toxicity of external Pro and P5C supply to Arabidopsis suggested that P5C dehydrogenase (P5CDH; EC 1.2.1.12) plays a crucial role in this process by degrading the toxic Pro catabolism intermediate P5C.	Proline	21-24	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	89-94
11532180-2	2001	Toxicity of external Pro and P5C supply to Arabidopsis suggested that P5C dehydrogenase (P5CDH; EC 1.2.1.12) plays a crucial role in this process by degrading the toxic Pro catabolism intermediate P5C.	Proline	21-24	pyrroline-5-carboxylate reductase 1	Homo sapiens	70-73
11493738-2	2001	In D category V types I and II, the amino acid at position 226 is alanine, which is typical of the prevalent RHD allele and is observed in all RHCE alleles encoding the antigen e. A proline at position 226 in RHCE encodes the antigen E. STUDY DESIGN AND METHODS: A blood sample of ccDEe phenotype was referred as suspected D category VI.	Proline	182-189	Rh blood group CcEe antigens	Homo sapiens	143-147
11493738-2	2001	In D category V types I and II, the amino acid at position 226 is alanine, which is typical of the prevalent RHD allele and is observed in all RHCE alleles encoding the antigen e. A proline at position 226 in RHCE encodes the antigen E. STUDY DESIGN AND METHODS: A blood sample of ccDEe phenotype was referred as suspected D category VI.	Proline	182-189	Rh blood group CcEe antigens	Homo sapiens	209-213
11371563-4	2001	However, the functional impact of the C terminus of DOC-2/DAB2, containing three proline-rich domains, has not been explored.	Proline	81-88	DAB adaptor protein 2	Homo sapiens	52-57
11371563-4	2001	However, the functional impact of the C terminus of DOC-2/DAB2, containing three proline-rich domains, has not been explored.	Proline	81-88	DAB adaptor protein 2	Homo sapiens	58-62
11371563-6	2001	Using sequence-specific peptides, we found that the second proline-rich domain of DOC-2/DAB2 is the key binding site to Grb2 in the presence of growth factors.	Proline	59-66	DAB adaptor protein 2	Homo sapiens	82-87
11371563-6	2001	Using sequence-specific peptides, we found that the second proline-rich domain of DOC-2/DAB2 is the key binding site to Grb2 in the presence of growth factors.	Proline	59-66	DAB adaptor protein 2	Homo sapiens	88-92
11371563-6	2001	Using sequence-specific peptides, we found that the second proline-rich domain of DOC-2/DAB2 is the key binding site to Grb2 in the presence of growth factors.	Proline	59-66	growth factor receptor bound protein 2	Homo sapiens	120-124
11352907-2	2001	In the current study, we have identified a new mSos-binding protein of 50 kDa (p50) that interacts with the mSos1 proline-rich domain.	Proline	114-121	nuclear factor kappa B subunit 1	Homo sapiens	79-82
11483358-9	2001	Compared to Mta3, the carboxy terminal end of Mta1 contains an additional nuclear localization signal (NLS) and a proline-rich Src homology 3 (SH3) ligand.	Proline	114-121	metastasis associated 1	Mus musculus	46-50
11453652-2	2001	Arpp protein is composed of 333 amino acids and contains four ankyrin-like repeat motifs in the middle portion of the protein, a PEST-like sequence and a lysine-rich sequence similar to a nuclear localization signal in the N-terminal region, and a proline-rich region containing consensus phosphorylation sites in the C-terminal region.	Proline	248-255	ankyrin repeat domain 2	Homo sapiens	0-4
11342538-4	2001	Our search for nuclear substrates led to the identification of the human proline-rich transcript, brain-expressed (hPRTB) protein, the ubiquitination and degradation of which is regulated by hRPF1/Nedd4.	Proline	73-80	DAZ associated protein 2	Homo sapiens	115-120
11340081-2	2001	The Nck Src homology (SH) 2/3 adaptor binds via its SH3 domains to a proline-rich region on WASP and N-WASP and has been implicated in recruitment of these proteins to sites of tyrosine phosphorylation.	Proline	69-76	NCK adaptor protein 1	Homo sapiens	4-7
11340081-2	2001	The Nck Src homology (SH) 2/3 adaptor binds via its SH3 domains to a proline-rich region on WASP and N-WASP and has been implicated in recruitment of these proteins to sites of tyrosine phosphorylation.	Proline	69-76	WASP actin nucleation promoting factor	Homo sapiens	92-96
11340081-2	2001	The Nck Src homology (SH) 2/3 adaptor binds via its SH3 domains to a proline-rich region on WASP and N-WASP and has been implicated in recruitment of these proteins to sites of tyrosine phosphorylation.	Proline	69-76	WASP like actin nucleation promoting factor	Homo sapiens	101-107
11352907-2	2001	In the current study, we have identified a new mSos-binding protein of 50 kDa (p50) that interacts with the mSos1 proline-rich domain.	Proline	114-121	SOS Ras/Rac guanine nucleotide exchange factor 1	Mus musculus	108-113
11352907-5	2001	PACSIN 2 shows enhanced binding to the mSos proline-rich domain in pull-down assays from brain extracts as compared with lung extracts, suggesting a tissue-specific regulation of the interaction.	Proline	44-51	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	0-8
11342538-4	2001	Our search for nuclear substrates led to the identification of the human proline-rich transcript, brain-expressed (hPRTB) protein, the ubiquitination and degradation of which is regulated by hRPF1/Nedd4.	Proline	73-80	ribosome production factor 1 homolog	Homo sapiens	191-196
11352907-6	2001	Proline to leucine mutations within the Src homology 3 domains of PACSIN 1 and 2 abolish their binding to mSos, demonstrating the specificity of the interactions.	Proline	0-7	protein kinase C and casein kinase substrate in neurons 1	Homo sapiens	66-80
11342538-4	2001	Our search for nuclear substrates led to the identification of the human proline-rich transcript, brain-expressed (hPRTB) protein, the ubiquitination and degradation of which is regulated by hRPF1/Nedd4.	Proline	73-80	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	197-202
11470507-0	2001	Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex.	Proline	70-77	RAN binding protein 9	Homo sapiens	11-17
11464277-8	2001	Because the amino acid sequence of PHF3 contains a PHD finger (also termed LAP motif), a TFIIS homology, a proline rich region and nuclear localization signals, it supposedly functions as a transcription factor.	Proline	107-114	PHD finger protein 3	Homo sapiens	35-39
11470507-4	2001	Thus, full-sized RanBPM cDNA encodes a long stretch of proline and glutamine residues in the N-terminal region.	Proline	55-62	RAN binding protein 9	Homo sapiens	17-23
11432831-3	2001	A proline-rich sequence of JNK1 is critical for the interaction of the kinase with the N-terminal Src homology 3 (SH3) domain of CrkII.	Proline	2-9	mitogen-activated protein kinase 8	Homo sapiens	27-31
11445074-7	2001	However, Pro or Lys in the P1 position and Pro in the P1" positions are incompatible with TPP-I activity.	Proline	9-12	tripeptidyl peptidase 1	Homo sapiens	90-95
11445074-7	2001	However, Pro or Lys in the P1 position and Pro in the P1" positions are incompatible with TPP-I activity.	Proline	43-46	tripeptidyl peptidase 1	Homo sapiens	90-95
11494134-6	2001	The major proline-rich region of Cbl was required for its phosphorylation by c-Abl, but not by a constitutively activated Abl mutant, suggesting Cbl activates c-Abl by engaging its SH3 domain.	Proline	10-17	Cbl proto-oncogene	Homo sapiens	33-36
11494134-6	2001	The major proline-rich region of Cbl was required for its phosphorylation by c-Abl, but not by a constitutively activated Abl mutant, suggesting Cbl activates c-Abl by engaging its SH3 domain.	Proline	10-17	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	77-82
11494134-6	2001	The major proline-rich region of Cbl was required for its phosphorylation by c-Abl, but not by a constitutively activated Abl mutant, suggesting Cbl activates c-Abl by engaging its SH3 domain.	Proline	10-17	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	79-82
11494134-6	2001	The major proline-rich region of Cbl was required for its phosphorylation by c-Abl, but not by a constitutively activated Abl mutant, suggesting Cbl activates c-Abl by engaging its SH3 domain.	Proline	10-17	Cbl proto-oncogene	Homo sapiens	145-148
11494134-6	2001	The major proline-rich region of Cbl was required for its phosphorylation by c-Abl, but not by a constitutively activated Abl mutant, suggesting Cbl activates c-Abl by engaging its SH3 domain.	Proline	10-17	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	159-164
11432831-3	2001	A proline-rich sequence of JNK1 is critical for the interaction of the kinase with the N-terminal Src homology 3 (SH3) domain of CrkII.	Proline	2-9	CRK proto-oncogene, adaptor protein	Homo sapiens	129-134
11432833-2	2001	The conformation of a subset of phosphorylated Ser/Thr-Pro motifs is regulated by the prolyl isomerase Pin1.	Proline	55-58	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	103-107
11566627-0	2001	Cytokine-inducing activity of a proline-rich polypeptide complex (PRP) from ovine colostrum and its active nonapeptide fragment analogs.	Proline	32-39	complement component 4 binding protein alpha	Homo sapiens	66-69
11432776-2	2001	By yeast two-hybrid screening of a human embryonic kidney 293 cell cDNA library with the PKNbeta linker region containing proline-rich motifs as a bait, clones encoding Graf (GAP for Rho Associated with Focal adhesion kinase) and a novel Graf-related protein, termed Graf2, were isolated.	Proline	122-129	protein kinase N3	Homo sapiens	89-96
11449371-5	2001	This demonstrates the importance of the penultimate proline in LD78beta(1 - 70) for CCR3 recognition.	Proline	52-59	C-C motif chemokine ligand 3 like 3	Homo sapiens	63-78
11449371-5	2001	This demonstrates the importance of the penultimate proline in LD78beta(1 - 70) for CCR3 recognition.	Proline	52-59	C-C motif chemokine receptor 3	Homo sapiens	84-88
11432776-2	2001	By yeast two-hybrid screening of a human embryonic kidney 293 cell cDNA library with the PKNbeta linker region containing proline-rich motifs as a bait, clones encoding Graf (GAP for Rho Associated with Focal adhesion kinase) and a novel Graf-related protein, termed Graf2, were isolated.	Proline	122-129	Rho GTPase activating protein 26	Homo sapiens	169-173
11262415-0	2001	Down-regulation by antisense oligonucleotides establishes a role for the proline-rich tyrosine kinase PYK2 in angiotensin ii-induced signaling in vascular smooth muscle.	Proline	73-80	protein tyrosine kinase 2 beta	Homo sapiens	102-106
11429426-2	2001	A recent report suggests that a polymorphism of the p53 tumour suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in HPV associated malignancies.	Proline	117-124	tumor protein p53	Homo sapiens	52-55
11429426-2	2001	A recent report suggests that a polymorphism of the p53 tumour suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in HPV associated malignancies.	Proline	117-124	tumor protein p53	Homo sapiens	180-183
11429426-7	2001	RESULTS: The proportions of p53 codon 72 genotypes found were 78% arginine homozygous, 2% proline homozygous, and 20% heterozygous among patients with skin cancer and 79% arginine homozygous, 3.5% proline homozygous, and 17.5% heterozygous among the control population.	Proline	90-97	tumor protein p53	Homo sapiens	28-31
11429426-7	2001	RESULTS: The proportions of p53 codon 72 genotypes found were 78% arginine homozygous, 2% proline homozygous, and 20% heterozygous among patients with skin cancer and 79% arginine homozygous, 3.5% proline homozygous, and 17.5% heterozygous among the control population.	Proline	197-204	tumor protein p53	Homo sapiens	28-31
11559749-0	2001	Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail.	Proline	52-59	Fas ligand	Homo sapiens	0-10
11559749-3	2001	Here, we define a proline-rich domain (PRD) in the cytoplasmic tail of FasL that is responsible for sorting FasL to secretory lysosomes.	Proline	18-25	Fas ligand	Homo sapiens	71-75
11559749-3	2001	Here, we define a proline-rich domain (PRD) in the cytoplasmic tail of FasL that is responsible for sorting FasL to secretory lysosomes.	Proline	18-25	Fas ligand	Homo sapiens	108-112
11480541-5	2001	Structure-activity relationships showed that the Trp-OBzl(CF3)2 moiety is essential for NK1 affinity and that the introduction of building units such as spirolactam, lactam or proline, leading to a constrained peptide, increased selectivity for NK1 receptors.	Proline	176-183	tachykinin receptor 1	Homo sapiens	245-248
11390650-6	2001	Additional deletion mutations revealed a new, 67-amino-acid functional domain within the proline-rich region of SLP-76, which we have termed the P-1 domain.	Proline	89-96	lymphocyte cytosolic protein 2	Homo sapiens	112-118
11390650-8	2001	The adjacent Gads-binding domain of SLP-76, also within the proline-rich region, mediates inducible recruitment of SLP-76 to a PLC-gamma1-containing complex via the recruitment of both PLC-gamma1 and Gads to another cell-type-specific adapter, LAT.	Proline	60-67	lymphocyte cytosolic protein 2	Homo sapiens	36-42
11390650-8	2001	The adjacent Gads-binding domain of SLP-76, also within the proline-rich region, mediates inducible recruitment of SLP-76 to a PLC-gamma1-containing complex via the recruitment of both PLC-gamma1 and Gads to another cell-type-specific adapter, LAT.	Proline	60-67	lymphocyte cytosolic protein 2	Homo sapiens	115-121
11390650-8	2001	The adjacent Gads-binding domain of SLP-76, also within the proline-rich region, mediates inducible recruitment of SLP-76 to a PLC-gamma1-containing complex via the recruitment of both PLC-gamma1 and Gads to another cell-type-specific adapter, LAT.	Proline	60-67	phospholipase C gamma 1	Homo sapiens	127-137
11390650-8	2001	The adjacent Gads-binding domain of SLP-76, also within the proline-rich region, mediates inducible recruitment of SLP-76 to a PLC-gamma1-containing complex via the recruitment of both PLC-gamma1 and Gads to another cell-type-specific adapter, LAT.	Proline	60-67	phospholipase C gamma 1	Homo sapiens	185-195
11390650-8	2001	The adjacent Gads-binding domain of SLP-76, also within the proline-rich region, mediates inducible recruitment of SLP-76 to a PLC-gamma1-containing complex via the recruitment of both PLC-gamma1 and Gads to another cell-type-specific adapter, LAT.	Proline	60-67	linker for activation of T cells	Homo sapiens	244-247
11445238-3	2001	In mouse, the homologous peptide, SPA-NPFF (Ser-Pro-Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-amide) was not detected.	Proline	48-51	surfactant associated protein A1	Mus musculus	34-37
11445238-3	2001	In mouse, the homologous peptide, SPA-NPFF (Ser-Pro-Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-amide) was not detected.	Proline	48-51	neuropeptide FF-amide peptide precursor	Mus musculus	38-42
11445238-3	2001	In mouse, the homologous peptide, SPA-NPFF (Ser-Pro-Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-amide) was not detected.	Proline	48-52	surfactant associated protein A1	Mus musculus	34-37
11445238-3	2001	In mouse, the homologous peptide, SPA-NPFF (Ser-Pro-Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-amide) was not detected.	Proline	48-52	neuropeptide FF-amide peptide precursor	Mus musculus	38-42
11294848-2	2001	A derivative of indolicidin, CP10A, has alanine residues substituted for proline residues and has improved activity against Gram-positive organisms.	Proline	73-80	cathelicidin-4	Bos taurus	16-27
11390973-2	2001	Two activating mutations, Ser-252 --&gt; Trp and Pro-253 --&gt; Arg, in fibroblast growth factor receptor 2 (FGFR2) account for nearly all known cases of AS.	Proline	49-52	fibroblast growth factor receptor 2	Homo sapiens	72-107
11390973-2	2001	Two activating mutations, Ser-252 --&gt; Trp and Pro-253 --&gt; Arg, in fibroblast growth factor receptor 2 (FGFR2) account for nearly all known cases of AS.	Proline	49-52	fibroblast growth factor receptor 2	Homo sapiens	109-114
11390973-5	2001	Moreover, based on these structures and sequence alignment of the FGF family, we propose that the Pro-253 --&gt; Arg mutation will indiscriminately increase the affinity of FGFR2 toward any FGF.	Proline	98-101	fibroblast growth factor receptor 2	Homo sapiens	173-178
11683387-4	2001	CrkRS has extensive proline-rich regions that match the consensus for SH3 and WW domain binding sites, and an RS domain that is predominantly found in splicing factors.	Proline	20-27	cyclin dependent kinase 12	Homo sapiens	0-5
11420621-4	2001	The length of the proline-rich region varies within primates; however, the length differences between human and primate Aipl1 do not correlate with evolutionary distance.	Proline	18-25	aryl hydrocarbon receptor interacting protein like 1	Homo sapiens	120-125
11437596-2	2001	Itk contains five domains in addition to the catalytic domain: pleckstrin homology, Tec homology which contains a proline-rich region, Src homology 3, and Src homology 2.	Proline	114-121	IL2 inducible T cell kinase	Homo sapiens	0-3
11437596-6	2001	A deletion mutant removing the pleckstrin homology domain and part of the Tec homology domain (Itk(Delta152)) had approximately 10-fold less activity than wild type, a mutant with an altered proline-rich domain (P158A,P159A) had a more dramatic 100-fold loss of activity, and the catalytic domain alone was essentially inactive.	Proline	191-198	IL2 inducible T cell kinase	Homo sapiens	95-98
11437596-10	2001	These comparisons, taken together with the similar K(m) values for ATP and SAM68 substrate between the wild-type and the mutant enzymes, indicate that the amino acids in the N-terminal 152 residues and proline-rich domains enhance catalysis by affecting turnover rate rather than substrate binding.	Proline	202-209	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	75-80
12585075-7	2001	Tet (0.1-10 mumol.L-1) treatment in vitro induced a concentration dependent depression [3H]-proline incorperation stimulated by NE or Ang II in AVSMCs from either Sham or RHR.	Proline	92-99	angiotensinogen	Rattus norvegicus	134-140
11262415-0	2001	Down-regulation by antisense oligonucleotides establishes a role for the proline-rich tyrosine kinase PYK2 in angiotensin ii-induced signaling in vascular smooth muscle.	Proline	73-80	angiotensinogen	Homo sapiens	110-124
11401606-2	2001	A T--&gt;C (thymine to cytosine) transition in the 29th nucleotide in the coding sequence results in a leucine to proline substitution at the 10th amino acid and is associated with increased serum levels of TGF-beta1.	Proline	114-121	transforming growth factor beta 1	Homo sapiens	207-216
11397085-3	2001	The predicted AtSERK1 protein contains an extracellular domain with a leucine zipper motif followed by five leucine-rich repeats, a proline-rich region, a single transmembrane region and an intracellular kinase domain.	Proline	132-139	somatic embryogenesis receptor-like kinase 1	Arabidopsis thaliana	14-21
11394886-4	2001	The protein possesses a region rich in Ala and Pro residues around the middle of pkmA open reading frame, which might be involved in the transmembrane function, as suggested by PhoA fusion protein analysis.	Proline	47-50	alkaline phosphatase	Amycolatopsis mediterranei U32	177-181
11397780-5	2001	We have found that in rat heart all mammalian homologues of known Drosophila clock genes (bmal1, clock, cry1, cry2, per1, per2, per3, dbp, hlf, and tef) show circadian patterns of expression and that the induction of clock output genes (the PAR [rich in proline and acidic amino acid residues] transcription factors dbp, hlf, and tef) is attenuated in the pressure-overloaded hypertrophied heart.	Proline	254-261	teflon	Drosophila melanogaster	148-151
11422604-0	2001	A leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y was not identified in the Japanese population.	Proline	16-23	neuropeptide Y	Homo sapiens	65-79
11279207-6	2001	Interestingly, HPK1 also inducibly associated with linker for activation of T cells (LAT) through its proline-rich motif and translocated into glycolipid-enriched microdomains (also called lipid rafts) following TCR/CD3 stimulation, suggesting a critical role for LAT in the regulation of HPK1.	Proline	102-109	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	15-19
11279207-6	2001	Interestingly, HPK1 also inducibly associated with linker for activation of T cells (LAT) through its proline-rich motif and translocated into glycolipid-enriched microdomains (also called lipid rafts) following TCR/CD3 stimulation, suggesting a critical role for LAT in the regulation of HPK1.	Proline	102-109	linker for activation of T cells	Homo sapiens	85-88
11458707-7	2001	Studies of NET gene structure in the proband revealed a coding mutation that converts a highly conserved transmembrane domain Ala residue to Pro.	Proline	141-144	solute carrier family 6 member 2	Homo sapiens	11-14
11422604-1	2001	OBJECTIVE: A Leu(7)-to-Pro(7) polymorphism exists in the signal peptide part of prepro-neuropeptide Y (NPY) and this polymorphism is associated with high serum cholesterol and LDL cholesterol levels in both Finnish and Dutch people.	Proline	23-26	neuropeptide Y	Homo sapiens	80-101
11422604-1	2001	OBJECTIVE: A Leu(7)-to-Pro(7) polymorphism exists in the signal peptide part of prepro-neuropeptide Y (NPY) and this polymorphism is associated with high serum cholesterol and LDL cholesterol levels in both Finnish and Dutch people.	Proline	23-26	neuropeptide Y	Homo sapiens	103-106
11422604-8	2001	CONCLUSION: The incidence of the Leu(7)-to-Pro(7) polymorphism in the signal peptide of NPY was extremely low in Japanese people, suggesting that the polymorphism producing Pro(7) is not one of the genetic determinant factors affecting serum cholesterol levels in Japanese people.	Proline	43-46	neuropeptide Y	Homo sapiens	88-91
11340173-3	2001	A single proline-to-serine substitution in the HCF-1 VP16 interaction domain causes a temperature-induced arrest of cell proliferation in hamster tsBN67 cells and prevents transcriptional activation by VP16.	Proline	9-16	host cell factor 1	Mesocricetus auratus	47-52
11404383-6	2001	Degradation was completely inhibited by proline-specific serine protease (prolyl endopeptidase) inhibitors but not by proteasome, calpain, and metalloprotease inhibitors.	Proline	40-47	prolyl endopeptidase	Homo sapiens	74-94
11340167-8	2001	PRC interacts in vitro with the NRF-1 DNA binding domain through two distinct recognition motifs that are separated by an unstructured proline-rich region.	Proline	135-142	PPARG related coactivator 1	Homo sapiens	0-3
11340167-8	2001	PRC interacts in vitro with the NRF-1 DNA binding domain through two distinct recognition motifs that are separated by an unstructured proline-rich region.	Proline	135-142	nuclear respiratory factor 1	Homo sapiens	32-37
11389437-2	2001	Pin1 targets the proline residue carboxy-terminal to the phosphorylated threonine or serine residue, which constitutes part of the phosphorylated mitogen-activated protein kinase (MAPK) site PXpT/SP.	Proline	17-24	dodo	Drosophila melanogaster	0-4
11359905-0	2001	The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation.	Proline	42-49	transcriptional regulator, SIN3A (yeast)	Mus musculus	16-22
11359905-0	2001	The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation.	Proline	42-49	tumor protein p53	Homo sapiens	65-68
11359905-4	2001	Stabilization of p53 by Sin3 requires the Sin3-binding domain, determined here to map to the proline-rich region of p53, from amino acids 61 to 75.	Proline	93-100	tumor protein p53	Homo sapiens	17-20
11359905-4	2001	Stabilization of p53 by Sin3 requires the Sin3-binding domain, determined here to map to the proline-rich region of p53, from amino acids 61 to 75.	Proline	93-100	SIN3 transcription regulator family member A	Homo sapiens	24-28
11359905-4	2001	Stabilization of p53 by Sin3 requires the Sin3-binding domain, determined here to map to the proline-rich region of p53, from amino acids 61 to 75.	Proline	93-100	SIN3 transcription regulator family member A	Homo sapiens	42-46
11359905-4	2001	Stabilization of p53 by Sin3 requires the Sin3-binding domain, determined here to map to the proline-rich region of p53, from amino acids 61 to 75.	Proline	93-100	tumor protein p53	Homo sapiens	116-119
11389444-3	2001	We show that in the presence of TGF-beta signalling, Smad2 interacts through its proline-rich PPXY motif with the tryptophan-rich WW domains of Smurf2, a recently identified E3 ubiquitin ligases.	Proline	81-88	transforming growth factor beta 1	Homo sapiens	32-40
11389444-3	2001	We show that in the presence of TGF-beta signalling, Smad2 interacts through its proline-rich PPXY motif with the tryptophan-rich WW domains of Smurf2, a recently identified E3 ubiquitin ligases.	Proline	81-88	SMAD family member 2	Homo sapiens	53-58
11340654-3	2001	To investigate the relationship between Ar-HN interaction and the stability of local and secondary structures of polypeptides and to improve the prediction of this interaction based on amino acid sequence, the structures of 560 nonhomologous proteins, from the Protein Data Bank, were searched for Ar-HN interactions between the aromatic ring of each Phe, Tyr, and Trp residue at position i and the backbone amide group of any residue, except Pro, at the positions i, i - 1, i - 2, i - 3, i + 1, i + 2, and i + 3.	Proline	261-264	Rho family GTPase 2	Homo sapiens	40-45
11391236-2	2001	Polymorphisms at codon 10, (Leu10--&gt;Pro) and codon 25 (Arg25--&gt;Pro) in the signal sequence of the TGF-beta1 gene regulate the production and secretion of the protein.	Proline	39-42	transforming growth factor beta 1	Homo sapiens	104-113
11477223-11	2001	Apo(a) KIV (7) contains a lysine- and proline-sensitive site capable of mediating binding to plasmin-modified fibrinogen, albeit with a lower apparent affinity than apo(a) KIV (10).	Proline	38-45	fibrinogen beta chain	Homo sapiens	110-120
11391236-2	2001	Polymorphisms at codon 10, (Leu10--&gt;Pro) and codon 25 (Arg25--&gt;Pro) in the signal sequence of the TGF-beta1 gene regulate the production and secretion of the protein.	Proline	69-72	transforming growth factor beta 1	Homo sapiens	104-113
11381094-5	2001	These interactions occur via two NPF motifs in the proline-rich domain of stonin 2 and Eps15 homology domains of Eps15, Eps15R, and intersectin 1.	Proline	51-58	stonin 2	Homo sapiens	74-82
11381094-5	2001	These interactions occur via two NPF motifs in the proline-rich domain of stonin 2 and Eps15 homology domains of Eps15, Eps15R, and intersectin 1.	Proline	51-58	epidermal growth factor receptor pathway substrate 15	Homo sapiens	87-92
11381094-5	2001	These interactions occur via two NPF motifs in the proline-rich domain of stonin 2 and Eps15 homology domains of Eps15, Eps15R, and intersectin 1.	Proline	51-58	epidermal growth factor receptor pathway substrate 15	Homo sapiens	113-118
11404024-7	2001	In addition, FST protein has a proline-rich region.	Proline	31-38	Frost	Drosophila melanogaster	13-16
11391236-4	2001	METHOD: TGF-beta1 polymorphisms, Leu10--&gt;Pro and Arg25--&gt;Pro, were determined in DNA from heart transplant recipients (n=252) and their donors (n=213), using sequence-specific oligonucleotide probing.	Proline	44-47	transforming growth factor beta 1	Homo sapiens	8-17
11491285-8	2001	Using peptide library screenings, we present data that demonstrate the high affinity of the Vesl 2 EVH1 domain towards peptide sequences containing a proline-rich core sequence (PPSPF) that requires additional charged amino acid residues on either side for specific binding.	Proline	150-157	homer scaffolding protein 2	Mus musculus	92-98
11353842-4	2001	Furthermore, Grb2 bound to tyrosine-phosphorylated FRS2 through its SH2 domain interacts primarily via its carboxyl-terminal SH3 domain with a proline-rich region in Gab1 and via its amino-terminal SH3 domain with the nucleotide exchange factor Sos1.	Proline	143-150	growth factor receptor bound protein 2	Homo sapiens	13-17
11353842-4	2001	Furthermore, Grb2 bound to tyrosine-phosphorylated FRS2 through its SH2 domain interacts primarily via its carboxyl-terminal SH3 domain with a proline-rich region in Gab1 and via its amino-terminal SH3 domain with the nucleotide exchange factor Sos1.	Proline	143-150	fibroblast growth factor receptor substrate 2	Homo sapiens	51-55
11381094-5	2001	These interactions occur via two NPF motifs in the proline-rich domain of stonin 2 and Eps15 homology domains of Eps15, Eps15R, and intersectin 1.	Proline	51-58	epidermal growth factor receptor pathway substrate 15 like 1	Homo sapiens	120-126
11381094-5	2001	These interactions occur via two NPF motifs in the proline-rich domain of stonin 2 and Eps15 homology domains of Eps15, Eps15R, and intersectin 1.	Proline	51-58	intersectin 1	Homo sapiens	132-145
11278563-3	2001	Tankyrase 2 is a 130-kDa protein, which lacks the N-terminal histidine/proline/serine-rich region of tankyrase, but contains a corresponding ankyrin repeat region, sterile alpha motif module, and poly(ADP-ribose) polymerase homology domain.	Proline	71-78	tankyrase 2	Homo sapiens	0-11
11264280-7	2001	Additionally, we show that PAI-1 inhibition of the Lys(37)-Lys(38)-Lys(39) --&gt; Pro-Gln-Glu mutant of APC is severely impaired, suggesting that, similar to tissue plasminogen activator, the basic 39-loop of APC plays a critical role in the reaction.	Proline	82-85	serpin family E member 1	Homo sapiens	27-32
11374906-2	2001	ESXR1 and Esx1 share 65% identity within their homeodomains and have glutamic acid-rich and proline-rich N- and C-terminal regions, respectively.	Proline	92-99	ESX homeobox 1	Homo sapiens	0-5
11374906-2	2001	ESXR1 and Esx1 share 65% identity within their homeodomains and have glutamic acid-rich and proline-rich N- and C-terminal regions, respectively.	Proline	92-99	ESX homeobox 1	Homo sapiens	10-14
11264280-7	2001	Additionally, we show that PAI-1 inhibition of the Lys(37)-Lys(38)-Lys(39) --&gt; Pro-Gln-Glu mutant of APC is severely impaired, suggesting that, similar to tissue plasminogen activator, the basic 39-loop of APC plays a critical role in the reaction.	Proline	82-85	APC regulator of WNT signaling pathway	Homo sapiens	104-107
11356192-4	2001	The NFAT-Pin1 interaction is mediated through the WW domain of Pin1 and the serine-proline-rich domains of NFAT.	Proline	83-90	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	9-13
11279064-7	2001	We confirmed that binding occurs at the RIGSDP motif using PS120 (NHE1 null) cells transfected with S703A-NHE1 or P705A-NHE1 (based on data indicating that 14-3-3 binding requires phosphoserine and +2 proline).	Proline	201-208	sodium/hydrogen exchanger 1	Cricetulus griseus	66-70
11334558-0	2001	Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro(30), Tyr(32), Leu(34)]NPY(28-36)-NH2 (BW1911U90).	Proline	83-86	neuropeptide Y	Homo sapiens	44-47
11279146-8	2001	Repression of CIITA requires either the N-terminal acidic and conserved PR motif or the proline-rich domain.	Proline	88-95	class II major histocompatibility complex transactivator	Homo sapiens	14-19
11278311-8	2001	An idealized substrate comprising the previously described optimal P4-P1 sequence (Ile-Glu-Pro-Asp) fused to the PI-9 P1"-P4" sequence was efficiently cleaved by granzyme B (k(cat)/K(m) 7.5 x 10(5) s(-1) M(-1)) and was also recognized by caspases.	Proline	91-94	granzyme B	Homo sapiens	162-172
11317364-6	2001	Most mutations resulted in substitutions for glycine: one of these, a doublet GG>CC transversion, created a unique Gly-->Pro missense mutation in the triple helical domain of COL1A2.	Proline	121-124	collagen type I alpha 2 chain	Homo sapiens	175-181
11334419-11	2001	The insulin sensitivity index decreased comparably in Pro/Pro and X/Ala (to 71 +/- 8 vs. 74 +/- 9% of basal, P = 0.8).	Proline	54-57	insulin	Homo sapiens	4-11
11334419-11	2001	The insulin sensitivity index decreased comparably in Pro/Pro and X/Ala (to 71 +/- 8 vs. 74 +/- 9% of basal, P = 0.8).	Proline	58-61	insulin	Homo sapiens	4-11
11322885-2	2001	Rat SBK comprises 417 amino-acid residues consisting of a serine/threonine protein kinase consensus sequence followed by a C-terminal proline-rich region.	Proline	134-141	SH3 domain binding kinase 1	Rattus norvegicus	4-7
11350120-4	2001	Sequence comparisons suggest that Eig3 is homologous to a human epidermal differentiation gene, XP5, and belongs to a family of at least 10 murine genes that are related to the small proline-rich genes involved in skin differentiation.	Proline	183-190	EIG3	Homo sapiens	34-38
11380621-4	2001	The interaction of the amino-terminal Src-homology (SH) 3 domain of c-Crk and the proline-rich motifs of c-Abl is an essential step for the phosphorylation of c-Crk by c-Abl, as well as the activation of c-Abl by c-Crk.	Proline	82-89	cyclin dependent kinase 20	Homo sapiens	68-73
11380621-4	2001	The interaction of the amino-terminal Src-homology (SH) 3 domain of c-Crk and the proline-rich motifs of c-Abl is an essential step for the phosphorylation of c-Crk by c-Abl, as well as the activation of c-Abl by c-Crk.	Proline	82-89	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	105-110
11380621-4	2001	The interaction of the amino-terminal Src-homology (SH) 3 domain of c-Crk and the proline-rich motifs of c-Abl is an essential step for the phosphorylation of c-Crk by c-Abl, as well as the activation of c-Abl by c-Crk.	Proline	82-89	cyclin dependent kinase 20	Homo sapiens	159-164
11380621-4	2001	The interaction of the amino-terminal Src-homology (SH) 3 domain of c-Crk and the proline-rich motifs of c-Abl is an essential step for the phosphorylation of c-Crk by c-Abl, as well as the activation of c-Abl by c-Crk.	Proline	82-89	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	168-173
11380621-4	2001	The interaction of the amino-terminal Src-homology (SH) 3 domain of c-Crk and the proline-rich motifs of c-Abl is an essential step for the phosphorylation of c-Crk by c-Abl, as well as the activation of c-Abl by c-Crk.	Proline	82-89	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	168-173
11380621-4	2001	The interaction of the amino-terminal Src-homology (SH) 3 domain of c-Crk and the proline-rich motifs of c-Abl is an essential step for the phosphorylation of c-Crk by c-Abl, as well as the activation of c-Abl by c-Crk.	Proline	82-89	cyclin dependent kinase 20	Homo sapiens	159-164
11380621-6	2001	Our data suggest that, in the absence of phosphorylation of the tyrosine Y221, the SH2 domain of c-Crk becomes free to bind to target molecules while the carboxyl-terminal SH3 domain of c-Crk binds to the proline-rich region of c-Abl, inducing the activation of c-Abl by c-Crk.	Proline	205-212	cyclin dependent kinase 20	Homo sapiens	97-102
11457149-1	2001	The Src-homology-3 (SH3) domain of the Caenorhabditis elegans protein Sem-5 binds proline-rich sequences.	Proline	82-89	Sex muscle abnormal protein 5	Caenorhabditis elegans	70-75
11311121-5	2001	Here we show that Ser(539) of eIF2Bepsilon, which is followed by proline, is phosphorylated specifically by two isoforms of dual-specificity tyrosine phosphorylated and regulated kinase (DYRK2 and DYRK1A), but only weakly or not at all by other "proline-directed" protein kinases tested.	Proline	65-72	eukaryotic translation initiation factor 2B subunit epsilon	Homo sapiens	30-42
11311121-5	2001	Here we show that Ser(539) of eIF2Bepsilon, which is followed by proline, is phosphorylated specifically by two isoforms of dual-specificity tyrosine phosphorylated and regulated kinase (DYRK2 and DYRK1A), but only weakly or not at all by other "proline-directed" protein kinases tested.	Proline	65-72	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	187-192
11311121-5	2001	Here we show that Ser(539) of eIF2Bepsilon, which is followed by proline, is phosphorylated specifically by two isoforms of dual-specificity tyrosine phosphorylated and regulated kinase (DYRK2 and DYRK1A), but only weakly or not at all by other "proline-directed" protein kinases tested.	Proline	65-72	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	197-203
11311121-5	2001	Here we show that Ser(539) of eIF2Bepsilon, which is followed by proline, is phosphorylated specifically by two isoforms of dual-specificity tyrosine phosphorylated and regulated kinase (DYRK2 and DYRK1A), but only weakly or not at all by other "proline-directed" protein kinases tested.	Proline	246-253	eukaryotic translation initiation factor 2B subunit epsilon	Homo sapiens	30-42
11311121-5	2001	Here we show that Ser(539) of eIF2Bepsilon, which is followed by proline, is phosphorylated specifically by two isoforms of dual-specificity tyrosine phosphorylated and regulated kinase (DYRK2 and DYRK1A), but only weakly or not at all by other "proline-directed" protein kinases tested.	Proline	246-253	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	187-192
11311121-5	2001	Here we show that Ser(539) of eIF2Bepsilon, which is followed by proline, is phosphorylated specifically by two isoforms of dual-specificity tyrosine phosphorylated and regulated kinase (DYRK2 and DYRK1A), but only weakly or not at all by other "proline-directed" protein kinases tested.	Proline	246-253	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	197-203
11331596-6	2001	The proline-rich domain of Prrp interacts with profilin, a protein that promotes actin polymerization.	Proline	4-11	prolactin releasing hormone L homeolog	Xenopus laevis	27-31
11331596-6	2001	The proline-rich domain of Prrp interacts with profilin, a protein that promotes actin polymerization.	Proline	4-11	profilin 1 S homeolog	Xenopus laevis	47-55
11380621-6	2001	Our data suggest that, in the absence of phosphorylation of the tyrosine Y221, the SH2 domain of c-Crk becomes free to bind to target molecules while the carboxyl-terminal SH3 domain of c-Crk binds to the proline-rich region of c-Abl, inducing the activation of c-Abl by c-Crk.	Proline	205-212	cyclin dependent kinase 20	Homo sapiens	186-191
11380621-6	2001	Our data suggest that, in the absence of phosphorylation of the tyrosine Y221, the SH2 domain of c-Crk becomes free to bind to target molecules while the carboxyl-terminal SH3 domain of c-Crk binds to the proline-rich region of c-Abl, inducing the activation of c-Abl by c-Crk.	Proline	205-212	cyclin dependent kinase 20	Homo sapiens	186-191
11389853-3	2001	We show that Pin1 catalytically generates a conformational change on the mitotic phosphatase Cdc25, as assayed by limited protease digestion, differential reactivity to a phosphoserine-proline-directed monoclonal antibody (MPM-2), and by changes in Cdc25 enzymatic activity.	Proline	185-192	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	13-17
11328597-5	2001	A Pro residue adjacent to the dephosphorylation site on the C-terminal side and acidic clusters around the dephosphorylation site had detrimental effects on dephosphorylation by CaMKPase.	Proline	2-5	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	178-186
11329366-6	2001	In addition to this activation mechanism, WISH also activates N-WASP independently of Cdc42 and PtdIns(4,5)P(2), by binding to the proline-rich region of N-WASP.	Proline	131-138	NCK interacting protein with SH3 domain	Homo sapiens	42-46
11329366-6	2001	In addition to this activation mechanism, WISH also activates N-WASP independently of Cdc42 and PtdIns(4,5)P(2), by binding to the proline-rich region of N-WASP.	Proline	131-138	WASP like actin nucleation promoting factor	Homo sapiens	62-68
11329366-6	2001	In addition to this activation mechanism, WISH also activates N-WASP independently of Cdc42 and PtdIns(4,5)P(2), by binding to the proline-rich region of N-WASP.	Proline	131-138	WASP like actin nucleation promoting factor	Homo sapiens	154-160
11313368-5	2001	Mutation of C-terminal proline residues abrogated the proliferative and cytokine regulatory features of CD28 costimulation while preserving Bcl-X(L) induction.	Proline	23-30	CD28 antigen	Mus musculus	104-108
11313368-5	2001	Mutation of C-terminal proline residues abrogated the proliferative and cytokine regulatory features of CD28 costimulation while preserving Bcl-X(L) induction.	Proline	23-30	BCL2-like 1	Mus musculus	140-148
11500636-2	2001	Aminopeptidase activities were studied by measuring the rate of hydrolysis of the artificial substrates Ala-, pGlu-, Pro-, Arg-, Asp- y Cis-2-naphthylamides (fluorimetrically detected at 412 rim with excitation at 345 nm).	Proline	117-120	carboxypeptidase Q	Homo sapiens	0-14
11341802-3	2001	Presence of conserved functional motifs in the inferred amino acid sequences, conserved secondary structures of the flanking tRNA(Pro) and tRNA(Thr), and Southern hybridization concordantly suggest that these cyt b represent functional mitochondrial genes and not nuclear transpositions.	Proline	130-133	CYTB	Lophura ignita	209-214
11389853-3	2001	We show that Pin1 catalytically generates a conformational change on the mitotic phosphatase Cdc25, as assayed by limited protease digestion, differential reactivity to a phosphoserine-proline-directed monoclonal antibody (MPM-2), and by changes in Cdc25 enzymatic activity.	Proline	185-192	cell division cycle 25C	Homo sapiens	93-98
11389853-3	2001	We show that Pin1 catalytically generates a conformational change on the mitotic phosphatase Cdc25, as assayed by limited protease digestion, differential reactivity to a phosphoserine-proline-directed monoclonal antibody (MPM-2), and by changes in Cdc25 enzymatic activity.	Proline	185-192	cell division cycle 25C	Homo sapiens	249-254
11401696-1	2001	In Saccharomyces cerevisiae, the ability to use proline as a nitrogen source requires the Put3p transcriptional regulator, which turns on the expression of the proline utilization genes, PUT1 and PUT2, in the presence of the inducer proline and in the absence of preferred nitrogen sources.	Proline	48-55	Put3p	Saccharomyces cerevisiae S288C	90-95
11401696-1	2001	In Saccharomyces cerevisiae, the ability to use proline as a nitrogen source requires the Put3p transcriptional regulator, which turns on the expression of the proline utilization genes, PUT1 and PUT2, in the presence of the inducer proline and in the absence of preferred nitrogen sources.	Proline	48-55	proline dehydrogenase	Saccharomyces cerevisiae S288C	187-191
11328883-2	2001	Previously we have shown that GST-Z2, a protein that contains three zinc fingers and a proline-rich multimerization domain from the polydactyl zinc finger protein RIP60 fused to glutathione S-transferase (GST), mediates DNA binding and looping in vitro.	Proline	87-94	glutathione S-transferase kappa 1	Homo sapiens	30-33
11401696-1	2001	In Saccharomyces cerevisiae, the ability to use proline as a nitrogen source requires the Put3p transcriptional regulator, which turns on the expression of the proline utilization genes, PUT1 and PUT2, in the presence of the inducer proline and in the absence of preferred nitrogen sources.	Proline	48-55	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	196-200
11401696-1	2001	In Saccharomyces cerevisiae, the ability to use proline as a nitrogen source requires the Put3p transcriptional regulator, which turns on the expression of the proline utilization genes, PUT1 and PUT2, in the presence of the inducer proline and in the absence of preferred nitrogen sources.	Proline	160-167	Put3p	Saccharomyces cerevisiae S288C	90-95
11328883-2	2001	Previously we have shown that GST-Z2, a protein that contains three zinc fingers and a proline-rich multimerization domain from the polydactyl zinc finger protein RIP60 fused to glutathione S-transferase (GST), mediates DNA binding and looping in vitro.	Proline	87-94	replication initiator 1	Homo sapiens	163-168
11401696-1	2001	In Saccharomyces cerevisiae, the ability to use proline as a nitrogen source requires the Put3p transcriptional regulator, which turns on the expression of the proline utilization genes, PUT1 and PUT2, in the presence of the inducer proline and in the absence of preferred nitrogen sources.	Proline	160-167	proline dehydrogenase	Saccharomyces cerevisiae S288C	187-191
11328883-2	2001	Previously we have shown that GST-Z2, a protein that contains three zinc fingers and a proline-rich multimerization domain from the polydactyl zinc finger protein RIP60 fused to glutathione S-transferase (GST), mediates DNA binding and looping in vitro.	Proline	87-94	glutathione S-transferase kappa 1	Homo sapiens	178-203
11328883-2	2001	Previously we have shown that GST-Z2, a protein that contains three zinc fingers and a proline-rich multimerization domain from the polydactyl zinc finger protein RIP60 fused to glutathione S-transferase (GST), mediates DNA binding and looping in vitro.	Proline	87-94	glutathione S-transferase kappa 1	Homo sapiens	205-208
11401696-1	2001	In Saccharomyces cerevisiae, the ability to use proline as a nitrogen source requires the Put3p transcriptional regulator, which turns on the expression of the proline utilization genes, PUT1 and PUT2, in the presence of the inducer proline and in the absence of preferred nitrogen sources.	Proline	160-167	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	196-200
11401696-1	2001	In Saccharomyces cerevisiae, the ability to use proline as a nitrogen source requires the Put3p transcriptional regulator, which turns on the expression of the proline utilization genes, PUT1 and PUT2, in the presence of the inducer proline and in the absence of preferred nitrogen sources.	Proline	160-167	Put3p	Saccharomyces cerevisiae S288C	90-95
11401696-1	2001	In Saccharomyces cerevisiae, the ability to use proline as a nitrogen source requires the Put3p transcriptional regulator, which turns on the expression of the proline utilization genes, PUT1 and PUT2, in the presence of the inducer proline and in the absence of preferred nitrogen sources.	Proline	160-167	proline dehydrogenase	Saccharomyces cerevisiae S288C	187-191
11401696-1	2001	In Saccharomyces cerevisiae, the ability to use proline as a nitrogen source requires the Put3p transcriptional regulator, which turns on the expression of the proline utilization genes, PUT1 and PUT2, in the presence of the inducer proline and in the absence of preferred nitrogen sources.	Proline	160-167	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	196-200
11401696-4	2001	In addition, the presence of proline causes a conformational change in the Put3 protein detected by increased sensitivity to thrombin or V8 protease.	Proline	29-36	Put3p	Saccharomyces cerevisiae S288C	75-79
11118438-2	2001	These PPIases consist of an NH(2)-terminal WW domain that binds to specific phosphoserine- or phosphothreonine-proline motifs present in a subset of phosphoproteins and a COOH-terminal PPIase domain that specifically isomerizes the phosphorylated serine/threonine-proline peptide bonds.	Proline	111-118	peptidylprolyl isomerase like 1	Homo sapiens	6-12
11523644-2	2001	These genes have been named ZmSERK1 and ZmSERK2 since features such as a putative leucine zipper (ZIP) and five leucine rich repeats in the extracellular domain, a proline-rich region (SPP) just upstream of the transmembrane domain and a C-terminal extension (C) after the kinase domain identify them as members of the SERK (somatic embryogenesis receptor-like kinase) family.	Proline	164-171	somatic embryogenesis receptor-like kinase 1	Zea mays	28-35
11523644-2	2001	These genes have been named ZmSERK1 and ZmSERK2 since features such as a putative leucine zipper (ZIP) and five leucine rich repeats in the extracellular domain, a proline-rich region (SPP) just upstream of the transmembrane domain and a C-terminal extension (C) after the kinase domain identify them as members of the SERK (somatic embryogenesis receptor-like kinase) family.	Proline	164-171	somatic embryogenesis receptor-like kinase 2	Zea mays	40-47
11118438-2	2001	These PPIases consist of an NH(2)-terminal WW domain that binds to specific phosphoserine- or phosphothreonine-proline motifs present in a subset of phosphoproteins and a COOH-terminal PPIase domain that specifically isomerizes the phosphorylated serine/threonine-proline peptide bonds.	Proline	264-271	peptidylprolyl isomerase like 1	Homo sapiens	6-12
11133985-6	2001	Loss-of-function and gain-of-function experiments using the yeast GAL4 DNA binding domain revealed that the proline-rich N-terminal domain (27 amino acids in length) is responsible for transactivation.	Proline	108-115	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	66-70
11292861-4	2001	Here we show that the interaction between human pVHL and a specific domain of the HIF-1alpha subunit is regulated through hydroxylation of a proline residue (HIF-1alpha P564) by an enzyme we have termed HIF-alpha prolyl-hydroxylase (HIF-PH).	Proline	141-148	von Hippel-Lindau tumor suppressor	Homo sapiens	48-52
11311058-1	2001	To identify novel peptides that inhibit the interaction between human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 and CD4, we constructed a targeted phage-displayed peptide library in which phenylalanine and proline were fixed at the fourth and sixth positions, respectively, because Phe43 and the adjacent beta-turn of CD4 are critical for interaction with gp120.	Proline	230-237	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	130-135
11278500-2	2001	The full-length cDNA, which encoded 722 amino acids, was identified as a VIP54-related gene containing an SH3 domain, proline-rich motifs, a serine/threonine-rich region, and a long C-terminal hydrophobic region.	Proline	118-125	NCK interacting protein with SH3 domain	Homo sapiens	73-78
11278902-6	2001	The meprin alpha subunit selected for small (e.g. serine, alanine) or hydrophobic (e.g. phenylalanine) residues in the P1 and P1" sites, and proline was the most preferred amino acid at the P2" position.	Proline	141-148	meprin 1 alpha	Mus musculus	4-16
11292861-4	2001	Here we show that the interaction between human pVHL and a specific domain of the HIF-1alpha subunit is regulated through hydroxylation of a proline residue (HIF-1alpha P564) by an enzyme we have termed HIF-alpha prolyl-hydroxylase (HIF-PH).	Proline	141-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
11292861-4	2001	Here we show that the interaction between human pVHL and a specific domain of the HIF-1alpha subunit is regulated through hydroxylation of a proline residue (HIF-1alpha P564) by an enzyme we have termed HIF-alpha prolyl-hydroxylase (HIF-PH).	Proline	141-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	158-168
11292862-0	2001	HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.	Proline	50-57	von Hippel-Lindau tumor suppressor	Homo sapiens	22-25
11292862-3	2001	We found that human pVHL binds to a short HIF-derived peptide when a conserved proline residue at the core of this peptide is hydroxylated.	Proline	79-86	von Hippel-Lindau tumor suppressor	Homo sapiens	20-24
11337749-4	2001	Mutation analysis of the ND gene (NDP) revealed two different novel missense mutations (L16P and S75P) that co-segregated with ND in each family, suggesting that the newly appearing proline at codon 16 or codon 75 alters the conformation of the ND protein and contributes to the severe phenotype of ND in each family.	Proline	182-189	norrin cystine knot growth factor NDP	Homo sapiens	34-37
11294654-1	2001	Galectin-3, a beta-galactoside binding protein, contains a C-terminal carbohydrate recognition domain (CRD) and an N-terminal domain that includes several repeats of a proline-tyrosine-glycine-rich motif.	Proline	168-175	galectin 3	Homo sapiens	0-10
11278754-3	2001	The interaction requires the C-terminal SH3-domain of Grb2/3-3 and the proline-rich sequence contained in p27 immediately downstream of the Cdk binding domain.	Proline	71-78	growth factor receptor bound protein 2	Homo sapiens	54-58
11309364-3	2001	PAX6 functions as a transcription factor and has two DNA binding domains (a paired domain and a homeodomain) which are joined by a linker, and a transactivation domain enriched in proline, serine and threonine (PST) at the C-terminus.	Proline	180-187	paired box 6	Homo sapiens	0-4
11278754-3	2001	The interaction requires the C-terminal SH3-domain of Grb2/3-3 and the proline-rich sequence contained in p27 immediately downstream of the Cdk binding domain.	Proline	71-78	dynactin subunit 6	Homo sapiens	106-109
11278242-3	2001	The 85-kDa betaPix-a protein contains an Src homology 3 domain, the tandem Dbl homology and Pleckstrin homology domains, a proline-rich region, and a GIT1-binding domain.	Proline	123-130	Rho guanine nucleotide exchange factor (GEF7)	Mus musculus	11-18
11350662-3	2001	Moreover, a trend was observed in that individuals with N-terminal amino acid insertions in the proline-rich motif of the p6(gag) protein were less likely to experience virological failure (OR, 0.17; 95% CI, 0.02-1.35; p = 0.09).	Proline	96-103	exosome component 9	Homo sapiens	122-129
11350662-7	2001	Moreover, there is some evidence that insertions in the proline-rich area of the p6(gag) protein may affect the virological response.	Proline	56-63	exosome component 9	Homo sapiens	84-87
11115514-5	2001	Using competition studies and affinity chromatography on peptide columns, we were able to identify a central proline-rich sequence as the nucleolin-interacting sequence in CD3epsilon.	Proline	109-116	nucleolin	Homo sapiens	138-147
11115514-5	2001	Using competition studies and affinity chromatography on peptide columns, we were able to identify a central proline-rich sequence as the nucleolin-interacting sequence in CD3epsilon.	Proline	109-116	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	172-182
11166304-3	2001	Since an increase in proline levels has been associated with overwintering in insects, and for salt and cold tolerance in plants, an RNase protection assay was developed to assess changes in transcript abundance for two genes encoding enzymes important for proline metabolism, pyrroline 5-carboxylate reductase and proline oxidase.	Proline	21-28	Pyrroline-5-carboxylate reductase-like 2	Drosophila melanogaster	277-310
11289057-1	2001	Recent studies have identified a common proline-to-alanine substitution (Pro12Ala) in the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2), a nuclear receptor that regulates adipocyte differentiation and possibly insulin sensitivity.	Proline	40-47	peroxisome proliferator activated receptor gamma	Homo sapiens	90-139
11289057-1	2001	Recent studies have identified a common proline-to-alanine substitution (Pro12Ala) in the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2), a nuclear receptor that regulates adipocyte differentiation and possibly insulin sensitivity.	Proline	40-47	peroxisome proliferator activated receptor gamma	Homo sapiens	141-152
11289057-1	2001	Recent studies have identified a common proline-to-alanine substitution (Pro12Ala) in the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2), a nuclear receptor that regulates adipocyte differentiation and possibly insulin sensitivity.	Proline	40-47	insulin	Homo sapiens	228-235
11241789-2	2001	The AF3p21 gene encodes a protein consisting of 722 amino acids, which has an SH3 (Src homology 3) domain, a proline-rich domain, and a bipartite nuclear localization signal.	Proline	109-116	NCK interacting protein with SH3 domain	Homo sapiens	4-10
11166304-3	2001	Since an increase in proline levels has been associated with overwintering in insects, and for salt and cold tolerance in plants, an RNase protection assay was developed to assess changes in transcript abundance for two genes encoding enzymes important for proline metabolism, pyrroline 5-carboxylate reductase and proline oxidase.	Proline	257-264	Pyrroline-5-carboxylate reductase-like 2	Drosophila melanogaster	277-310
11166304-4	2001	The mRNA levels did not change in response to low temperature, but the high level of pyrroline 5-carboxylate reductase transcript is consistent with the interpretation that a large proline pool is important for Drosophila metabolism and survival during cold stress.	Proline	181-188	Pyrroline-5-carboxylate reductase-like 2	Drosophila melanogaster	85-118
11451388-1	2001	Prolidase [EC 3.4.13.9] is a ubiquitously distributed imidodipeptidase that catalyzes the hydrolysis of C-terminal proline-containing dipeptides.	Proline	115-122	peptidase D	Homo sapiens	0-9
11294912-1	2001	Testicular protein kinase 1 (TESK1) is a serine/threonine kinase with a structure composed of a kinase domain related to those of LIM-kinases and a unique C-terminal proline-rich domain.	Proline	166-173	testis associated actin remodelling kinase 1	Homo sapiens	0-27
11294912-1	2001	Testicular protein kinase 1 (TESK1) is a serine/threonine kinase with a structure composed of a kinase domain related to those of LIM-kinases and a unique C-terminal proline-rich domain.	Proline	166-173	testis associated actin remodelling kinase 1	Homo sapiens	29-34
11451388-1	2001	Prolidase [EC 3.4.13.9] is a ubiquitously distributed imidodipeptidase that catalyzes the hydrolysis of C-terminal proline-containing dipeptides.	Proline	115-122	peptidase D	Homo sapiens	54-70
11338665-0	2001	Decreased cytotoxicity and increased antimitotic activity of a proline analogue of chlorambucil as a prodrug susceptible to the action of fibroblast"s prolidase.	Proline	63-70	peptidase D	Homo sapiens	151-160
11338665-1	2001	We synthesized an proline analogue of chlorambucil (CH-pro) as a prodrug susceptible to the action of ubiquitously distributed, cytosolic imidopeptidase--prolidase [E.C.3.4.13.9].	Proline	18-25	peptidase D	Homo sapiens	154-163
11338665-2	2001	A conjugation of chlorambucil (CH) with proline through an imido-bond resulted in the formation of a good substrate for prolidase.	Proline	40-47	peptidase D	Homo sapiens	120-129
11152479-3	2001	The TMX protein possesses an N-terminal signal peptide followed by one thioredoxin (Trx)-like domain with a unique active site sequence, Cys-Pro-Ala-Cys, and a potential transmembrane domain.	Proline	141-144	thioredoxin related transmembrane protein 1	Homo sapiens	4-7
11430426-4	2001	The two 699 amino acid predicted protein sequences differ in two residues at positions 341 (Gly or Cys within the repression domain) and 448 (Pro or Ser) and show over 80, 70 and 60% homology to maize, rice and oat VP1 proteins respectively.	Proline	142-145	regulatory protein viviparous-1	Zea mays	215-218
11124960-9	2001	Site-directed mutagenesis and stable transfection of mutants in CHO cells indicated that Pro(74), Pro(87), Phe(90), and Trp(110) are indeed important for VIP binding and activation of adenylyl cyclase activation.	Proline	89-92	VIP peptides	Cricetulus griseus	154-157
11124960-9	2001	Site-directed mutagenesis and stable transfection of mutants in CHO cells indicated that Pro(74), Pro(87), Phe(90), and Trp(110) are indeed important for VIP binding and activation of adenylyl cyclase activation.	Proline	98-101	VIP peptides	Cricetulus griseus	154-157
11134025-7	2001	The docking domain of PKC3 differs from classical PTB ligands by the absence of Tyr and Pro.	Proline	88-91	Protein kinase C-like 3	Caenorhabditis elegans	22-26
11152479-3	2001	The TMX protein possesses an N-terminal signal peptide followed by one thioredoxin (Trx)-like domain with a unique active site sequence, Cys-Pro-Ala-Cys, and a potential transmembrane domain.	Proline	141-144	thioredoxin	Homo sapiens	84-87
11134026-3	2001	The cytoplasmic domain of Sema4C contains a proline-rich region that may interact with some signaling proteins.	Proline	44-51	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	Mus musculus	26-32
11313918-4	2001	However, the Grap2 protein has a unique 120-amino acid glutamine- and proline-rich domain between the SH2 and C-terminal SH3 domains.	Proline	70-77	GRB2 related adaptor protein 2	Homo sapiens	13-18
11313918-8	2001	The interaction was mediated by the carboxyl-terminal SH3 domain of Grap2 with the second proline-rich motif of HPK1.	Proline	90-97	GRB2 related adaptor protein 2	Homo sapiens	68-73
11313918-8	2001	The interaction was mediated by the carboxyl-terminal SH3 domain of Grap2 with the second proline-rich motif of HPK1.	Proline	90-97	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	112-116
11108720-6	2001	We demonstrate that the inhibitory effects of the S6K2 C-terminal domain are only partly attributable to the nuclear localization signal but that three C-terminal proline-directed potential mitogen-activated protein kinase phosphorylation sites are critical mediators of this inhibitory effect.	Proline	163-170	ribosomal protein S6 kinase B2	Homo sapiens	50-54
11110801-12	2001	Our combined studies indicate that most, if not all, of the Ser-Pro motifs in human PR are sites for phosphorylation.	Proline	64-67	progesterone receptor	Homo sapiens	84-86
11238453-4	2001	PYK2 interacts with PSGAP Src homology 3 domain via the carboxyl-terminal proline-rich sequence.	Proline	74-81	protein tyrosine kinase 2 beta	Homo sapiens	0-4
11258927-8	2001	From the comparison of the presence or absence of interaction with various truncated forms of the proteins, we confirmed that the SH3 domain of p40(phox) interacts with the C-terminal proline rich region of p47(phox).	Proline	184-191	interleukin 9	Homo sapiens	144-147
11258927-8	2001	From the comparison of the presence or absence of interaction with various truncated forms of the proteins, we confirmed that the SH3 domain of p40(phox) interacts with the C-terminal proline rich region of p47(phox).	Proline	184-191	pleckstrin	Homo sapiens	207-210
11116155-2	2001	INP54 encodes a protein of 44 kDa which consists of a 5-phosphatase domain and a C-terminal leucine-rich tail, but lacks the N-terminal SacI domain and proline-rich region found in the other three yeast 5-phosphatases.	Proline	152-159	phosphoinositide 5-phosphatase INP54	Saccharomyces cerevisiae S288C	0-5
11258910-3	2001	The deduced GP1 amino acid sequence displays two Ser-Pro-rich domains, one with a repeating (SP)(x)() motif and the other with a repeating (PPSPX)(x)() motif.	Proline	53-56	uncharacterized protein	Chlamydomonas reinhardtii	12-15
11237732-4	2001	FRAT2 and FRAT1 were more homologous in the acidic domain (96% identity), the proline-rich domain (92% identity), and the GSK-3beta binding domain (100% identity).	Proline	78-85	FRAT regulator of WNT signaling pathway 2	Homo sapiens	0-5
11401446-3	2001	The conserved extracellular domain features found in rat, mouse, and human PV-1 protein are four N-glycosylation sites, two coiled-coil domains, a proline-rich region, and even cysteine spacing.	Proline	147-154	plasmalemma vesicle associated protein	Homo sapiens	75-79
11084050-4	2001	Deletion of PRO1, the first enzyme of the proline biosynthesis pathway, or PRO2 eliminated the suppression, suggesting that gamma-glutamyl phosphate, the product of Pro1 and the physiological substrate of Pro2, is required as an obligate substrate of suppressor alleles of PRO2 for glutathione synthesis.	Proline	42-49	glutamate 5-kinase	Saccharomyces cerevisiae S288C	12-16
11084050-4	2001	Deletion of PRO1, the first enzyme of the proline biosynthesis pathway, or PRO2 eliminated the suppression, suggesting that gamma-glutamyl phosphate, the product of Pro1 and the physiological substrate of Pro2, is required as an obligate substrate of suppressor alleles of PRO2 for glutathione synthesis.	Proline	42-49	glutamate 5-kinase	Saccharomyces cerevisiae S288C	165-169
11164950-0	2001	Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52.	Proline	50-57	glomulin, FKBP associated protein	Homo sapiens	12-38
11164950-0	2001	Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52.	Proline	50-57	glomulin, FKBP associated protein	Homo sapiens	40-45
11164950-0	2001	Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52.	Proline	50-57	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	92-98
11164950-0	2001	Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52.	Proline	50-57	FKBP prolyl isomerase 4	Homo sapiens	103-109
11164950-9	2001	We sequentially point mutated proline sites on FAP48 and checked the mutant proteins for interaction with FKBP12 and FKBP52.	Proline	30-37	glomulin, FKBP associated protein	Homo sapiens	47-52
11237732-4	2001	FRAT2 and FRAT1 were more homologous in the acidic domain (96% identity), the proline-rich domain (92% identity), and the GSK-3beta binding domain (100% identity).	Proline	78-85	FRAT regulator of WNT signaling pathway 1	Homo sapiens	10-15
11238453-4	2001	PYK2 interacts with PSGAP Src homology 3 domain via the carboxyl-terminal proline-rich sequence.	Proline	74-81	Rho GTPase activating protein 10	Homo sapiens	20-25
12160237-2	2001	WASP, the gene responsible for WAS, has been identified by positional cloning, contains a PH domain, a GBD domain, a proline rich region, and a verprolin/cofilin homology domain.	Proline	117-124	WASP actin nucleation promoting factor	Homo sapiens	0-4
11222379-6	2001	Surprisingly, C-terminally truncated forms of SHIP, lacking different amounts of the proline rich C-terminus, could not revert the SHIP(-/-) response at all.	Proline	85-92	inositol polyphosphate-5-phosphatase D	Mus musculus	46-50
11280728-0	2001	Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species.	Proline	76-83	proline dehydrogenase	Mus musculus	0-15
11280728-0	2001	Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species.	Proline	76-83	tumor protein p53	Homo sapiens	28-31
11280728-1	2001	The p53-dependent initiation of apoptosis is accompanied by the induction of proline oxidase (POX), a mitochondrial enzyme catalyzing the conversion of proline to pyrroline-5-carboxylate with the concomitant transfer of electrons to cytochrome c.	Proline	77-84	tumor protein p53	Homo sapiens	4-7
11280728-1	2001	The p53-dependent initiation of apoptosis is accompanied by the induction of proline oxidase (POX), a mitochondrial enzyme catalyzing the conversion of proline to pyrroline-5-carboxylate with the concomitant transfer of electrons to cytochrome c.	Proline	77-84	proline dehydrogenase 1	Homo sapiens	94-97
11280728-1	2001	The p53-dependent initiation of apoptosis is accompanied by the induction of proline oxidase (POX), a mitochondrial enzyme catalyzing the conversion of proline to pyrroline-5-carboxylate with the concomitant transfer of electrons to cytochrome c.	Proline	77-84	cytochrome c, somatic	Homo sapiens	233-245
11280728-4	2001	In cells expressing POX, the addition of proline increases reactive oxygen species (ROS) generation in a concentration-dependent manner; glutamate, a downstream product of proline oxidation, had no effect.	Proline	41-48	proline dehydrogenase 1	Homo sapiens	20-23
11280728-4	2001	In cells expressing POX, the addition of proline increases reactive oxygen species (ROS) generation in a concentration-dependent manner; glutamate, a downstream product of proline oxidation, had no effect.	Proline	172-179	proline dehydrogenase 1	Homo sapiens	20-23
11248668-9	2001	Cdk5 has been characterized as a proline-directed Ser/Thr protein kinase, that contributes to phosphorylation of human tau on Ser202, Thr205, Ser235 and Ser404.	Proline	33-40	cyclin dependent kinase 5	Homo sapiens	0-4
11248668-9	2001	Cdk5 has been characterized as a proline-directed Ser/Thr protein kinase, that contributes to phosphorylation of human tau on Ser202, Thr205, Ser235 and Ser404.	Proline	33-40	microtubule associated protein tau	Homo sapiens	119-122
11181800-8	2001	Compared with apoE3, receptor-binding activities of apoE2 (Arg(158) Cys), apoE1 (Arg(146) Glu), and apoE2 Sendai (Arg(145) Pro) all were less than 5%.	Proline	123-126	apolipoprotein E	Homo sapiens	100-105
11181800-11	2001	ApoE2 Sendai (Arg(145) Pro) represents the only known mutation within the heparin-binding domain of apoE (residues 142 through 147), revealing diminished receptor binding and almost normal heparin binding.	Proline	23-26	apolipoprotein E	Homo sapiens	0-5
11181800-11	2001	ApoE2 Sendai (Arg(145) Pro) represents the only known mutation within the heparin-binding domain of apoE (residues 142 through 147), revealing diminished receptor binding and almost normal heparin binding.	Proline	23-26	apolipoprotein E	Homo sapiens	100-104
11312522-1	2001	The proton affinity and gas-phase basicity of proline were evaluated by using density functional theory coupling the B3-LYP hybrid functional with the extended 6--311++G** basis set.	Proline	46-53	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	120-123
11280728-8	2001	Again, we found a proline-dependent ROS increase with POX expression.	Proline	18-25	proline dehydrogenase 1	Homo sapiens	54-57
11280728-9	2001	We hypothesize that proline oxidation supports the generation of ROS by donating reducing potential to an electron transport chain altered either by p53-dependent mechanisms or by overexpression of POX.	Proline	20-27	tumor protein p53	Homo sapiens	149-152
11280728-9	2001	We hypothesize that proline oxidation supports the generation of ROS by donating reducing potential to an electron transport chain altered either by p53-dependent mechanisms or by overexpression of POX.	Proline	20-27	proline dehydrogenase 1	Homo sapiens	198-201
11401436-2	2001	Here, we report the identification, cloning, physical mapping, and expression pattern of BCL2L12, a novel gene that encodes a BCL2-like proline-rich protein.	Proline	136-143	BCL2 like 12	Homo sapiens	89-96
11401436-8	2001	The BCL2L12 protein contains one BH2 homology domain, one proline-rich region similar to the TC21 protein and, five consensus PXXP tetrapeptide sequences.	Proline	58-65	BCL2 like 12	Homo sapiens	4-11
11181572-2	2001	In order, FGD1 is composed of a proline-rich N-terminal region, adjacent GEF and pleckstrin homology (PH) domains, a FYVE-finger domain and a second C-terminal PH domain (PH2), structural motifs involved in signaling and subcellular localization.	Proline	32-39	FYVE, RhoGEF and PH domain containing 1	Mus musculus	10-14
11226878-9	2001	Phylogenetic analysis and comparison of the gene structure showed that the DEC1 protein is a member of a new subgroup of the proline bHLH protein family that diverged earlier than other proline bHLH proteins including HES, hairy and E(spl).	Proline	125-132	deleted in esophageal cancer 1	Homo sapiens	75-79
11226878-9	2001	Phylogenetic analysis and comparison of the gene structure showed that the DEC1 protein is a member of a new subgroup of the proline bHLH protein family that diverged earlier than other proline bHLH proteins including HES, hairy and E(spl).	Proline	186-193	deleted in esophageal cancer 1	Homo sapiens	75-79
11243732-6	2001	This proline residue is conserved in P450c17 of other species and other human P450 proteins.	Proline	5-12	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	37-44
11251084-0	2001	The Chlamydomonas PF6 locus encodes a large alanine/proline-rich polypeptide that is required for assembly of a central pair projection and regulates flagellar motility.	Proline	52-59	sperm associated antigen 17	Homo sapiens	18-21
11251084-6	2001	Sequence analysis indicates that the PF6 gene encodes a large polypeptide that contains numerous alanine-rich, proline-rich, and basic domains and has limited homology to an expressed sequence tag derived from a human testis cDNA library.	Proline	111-118	sperm associated antigen 17	Homo sapiens	37-40
11355444-8	2001	RESULTS: Recombinant gp120-CH-Sepharose chromatography of one subject"s parotid saliva revealed specific binding of human parotid basic proline-rich proteins, most prominently one with an apparent molecular weight of 37 kDa.	Proline	136-143	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	21-26
11355444-15	2001	Since the inhibition is detectable with the MAGI assay, its mechanism of action involves virus-host cell interaction prior to the introduction of the tat gene product into the host cell and may be through the binding of the basic proline-rich proteins to the HIV-I gp120 coat of the virus.	Proline	230-237	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	265-270
11222476-6	2001	TGF-beta(1) markedly increased the capacity of VSMCs to generate the polyamine putrescine and L-proline from extracellular L-arginine.	Proline	94-103	transforming growth factor beta 1	Homo sapiens	0-11
11222675-1	2001	The carboxy terminus-encoding portion of the gag gene of Mason-Pfizer monkey virus (M-PMV), the prototype immunosuppressive primate type D retrovirus, encodes a 36-amino-acid, proline-rich protein domain that, in the mature virion, becomes the p4 capsid protein.	Proline	176-183	Pr78	Mason-Pfizer monkey virus	45-48
11287089-3	2001	The most striking result was the increase in affinity for the rat receptor, but not for human or guinea pig, when amino acid 34 was replaced with proline; [Ahx(8-20),Pro(34)]NPY bound to the rat Y4 receptor with 20-fold higher affinity than [Ahx(8-20)]NPY.	Proline	146-153	RNA, Ro60-associated Y4	Homo sapiens	195-197
11222476-7	2001	The TGF-beta(1)-mediated increase in putrescine and L-proline production was reversed by methyl-L-arginine, a competitive inhibitor of cationic amino acid transport, or by hydroxy-L-arginine, an arginase inhibitor.	Proline	52-61	transforming growth factor beta 1	Homo sapiens	4-14
11222476-10	2001	CONCLUSIONS: These results demonstrate that TGF-beta(1) stimulates polyamine and L-proline synthesis by inducing the genes that regulate the transport and metabolism of L-arginine.	Proline	81-90	transforming growth factor beta 1	Homo sapiens	44-55
11222476-11	2001	In addition, they show that TGF-beta(1)-stimulated collagen production is dependent on L-proline formation.	Proline	87-96	transforming growth factor beta 1	Homo sapiens	28-38
11222476-12	2001	The ability of TGF-beta(1) to upregulate L-arginine transport and direct its metabolism to polyamines and L-proline may contribute to arterial remodeling at sites of vascular damage.	Proline	106-115	transforming growth factor beta 1	Homo sapiens	15-26
11226433-1	2001	gamma-Glutamyl semialdehyde is a primary oxidation product of apolipoprotein (apo) B-100 proline (Pro) and arginine (Arg) side chain residues.	Proline	89-96	apolipoprotein B	Homo sapiens	62-88
11243732-8	2001	The proline residue probably causes a turn in the meander region of P450c17, and we hypothesize, by comparison to homologous proteins, that the change in the protein conformation may abolish heme incorporation or may prevent P450c17 from interacting with electron donors.	Proline	4-11	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	68-75
11243732-8	2001	The proline residue probably causes a turn in the meander region of P450c17, and we hypothesize, by comparison to homologous proteins, that the change in the protein conformation may abolish heme incorporation or may prevent P450c17 from interacting with electron donors.	Proline	4-11	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	225-232
11071884-6	2001	Further studies indicated that the domain affecting Vif self-association is located at the C terminus of this protein, especially the proline-enriched 151-164 region.	Proline	134-141	Vif	Human immunodeficiency virus 1	52-55
11226433-1	2001	gamma-Glutamyl semialdehyde is a primary oxidation product of apolipoprotein (apo) B-100 proline (Pro) and arginine (Arg) side chain residues.	Proline	98-101	apolipoprotein B	Homo sapiens	62-88
11067845-5	2001	The c-Cbl-binding site for CMS mapped to the carboxyl terminus of c-Cbl and is different from the proline-rich region known to bind SH3-containing proteins.	Proline	98-105	Cbl proto-oncogene	Homo sapiens	4-9
11178911-6	2001	Binding experiments on Grb2 and peptides containing two different proline-rich sequences indicate that Grb2 adapts the relative position and orientation of the two SH3 domains to bind bivalently to the target peptide sequences.	Proline	66-73	growth factor receptor bound protein 2	Homo sapiens	23-27
11178911-6	2001	Binding experiments on Grb2 and peptides containing two different proline-rich sequences indicate that Grb2 adapts the relative position and orientation of the two SH3 domains to bind bivalently to the target peptide sequences.	Proline	66-73	growth factor receptor bound protein 2	Homo sapiens	103-107
11042197-8	2001	Ile(183) --&gt; Pro mutant acts in an inhibitory manner on wild type Csx/Nkx2.5 transcriptional activity through the ANF promoter in 10T1/2 cells.	Proline	16-19	NK2 homeobox 5	Mus musculus	69-72
11042197-8	2001	Ile(183) --&gt; Pro mutant acts in an inhibitory manner on wild type Csx/Nkx2.5 transcriptional activity through the ANF promoter in 10T1/2 cells.	Proline	16-19	NK2 homeobox 5	Mus musculus	73-79
11042197-8	2001	Ile(183) --&gt; Pro mutant acts in an inhibitory manner on wild type Csx/Nkx2.5 transcriptional activity through the ANF promoter in 10T1/2 cells.	Proline	16-19	natriuretic peptide type A	Mus musculus	117-120
11170455-8	2001	Mutation of a glutamate to proline, but not alanine, also disrupted the interaction between E6 and E6AP protein, suggesting that the E6-binding motif of the E6AP protein must be helical when bound to E6.	Proline	27-34	ubiquitin protein ligase E3A	Homo sapiens	99-103
11237604-2	2001	Using both existing and newly developed tools to analyze transmembrane segments of all available membrane protein three-dimensional structures, including that very recently elucidated for the GPCR, rhodopsin, we report here the finding of frequent non-alpha-helical components, i.e. 3(10)-helices ("tight turns"), pi-helices ("wide turns") and intrahelical kinks (often due to residues other than proline).	Proline	397-404	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	192-196
11237604-2	2001	Using both existing and newly developed tools to analyze transmembrane segments of all available membrane protein three-dimensional structures, including that very recently elucidated for the GPCR, rhodopsin, we report here the finding of frequent non-alpha-helical components, i.e. 3(10)-helices ("tight turns"), pi-helices ("wide turns") and intrahelical kinks (often due to residues other than proline).	Proline	397-404	rhodopsin	Homo sapiens	198-207
11170644-5	2001	It showed that the hit compound is located in the active site of MIF containing the N-terminal proline which plays an important role in the tautomerase reaction and forms several hydrogen bonds and undergoes hydrophobic interactions.	Proline	95-102	macrophage migration inhibitory factor	Homo sapiens	65-68
11170644-6	2001	A crystallographic study also revealed that there is a hydrophobic surface which consists of Pro-33, Tyr-36, Trp-108, and Phe-113 at the rim of the active site of MIF, and molecular modeling studies indicated that several more potent hit compounds have the aromatic rings which can interact with this hydrophobic surface.	Proline	93-96	macrophage migration inhibitory factor	Homo sapiens	163-166
11314008-3	2001	Core sequence of the predicted clam p53 (Map53) and p73 (Map73) proteins is virtually identical and includes the following highly conserved regions: the transcriptional activation domain (TAD), MDM2 binding site, ATM phosphorylation site, proline rich domain, DNA binding domains (DBDs) II-V, nuclear import and export signals and the tetramerization domain.	Proline	239-246	tumor protein p53	Homo sapiens	36-39
11314008-3	2001	Core sequence of the predicted clam p53 (Map53) and p73 (Map73) proteins is virtually identical and includes the following highly conserved regions: the transcriptional activation domain (TAD), MDM2 binding site, ATM phosphorylation site, proline rich domain, DNA binding domains (DBDs) II-V, nuclear import and export signals and the tetramerization domain.	Proline	239-246	tumor protein p73	Homo sapiens	52-55
11087752-7	2001	A distal carboxyl-terminal proline-rich region in Cbl-b was mapped to contain the primary binding sequences for the SH3 domain of p85.	Proline	27-34	Cbl proto-oncogene B	Homo sapiens	50-55
11087752-7	2001	A distal carboxyl-terminal proline-rich region in Cbl-b was mapped to contain the primary binding sequences for the SH3 domain of p85.	Proline	27-34	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	130-133
11087752-8	2001	Deletion of either the distal proline-rich region in Cbl-b or the SH3 domain of p85 severely reduced ubiquitin conjugation to p85.	Proline	30-37	Cbl proto-oncogene B	Homo sapiens	53-58
11087752-8	2001	Deletion of either the distal proline-rich region in Cbl-b or the SH3 domain of p85 severely reduced ubiquitin conjugation to p85.	Proline	30-37	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	126-129
11170455-8	2001	Mutation of a glutamate to proline, but not alanine, also disrupted the interaction between E6 and E6AP protein, suggesting that the E6-binding motif of the E6AP protein must be helical when bound to E6.	Proline	27-34	ubiquitin protein ligase E3A	Homo sapiens	157-161
11160012-3	2001	The metB mutant was a prototrophic strain, whereas the proC and trpD mutants were auxotrophic for proline and tryptophan, respectively.	Proline	98-105	anthranilate phosphoribosyltransferase	Mycobacterium tuberculosis H37Rv	64-68
11058590-13	2001	WOX1 colocalizes with p53 in the cytosol and binds to the proline-rich region of p53 via its WW domains.	Proline	58-65	WW domain-containing oxidoreductase	Mus musculus	0-4
11058590-13	2001	WOX1 colocalizes with p53 in the cytosol and binds to the proline-rich region of p53 via its WW domains.	Proline	58-65	transformation related protein 53, pseudogene	Mus musculus	81-84
11161712-5	2001	PSF comprises an N-terminal proline- and glutamine-rich domain, two RRMs (RRM1 and RRM2), and a C-terminal region that contains two nuclear localization signals, both of which are required for complete nuclear localization.	Proline	28-35	splicing factor proline and glutamine rich	Homo sapiens	0-3
11300350-0	2001	Hb Mont Saint Aignan [beta128(H6)Ala-->Pro]: a new unstable variant leading to chronic microcytic anemia.	Proline	39-42	amyloid beta precursor protein	Homo sapiens	9-10
11300350-1	2001	Hb Mont Saint-Aignan [beta128(H6)Ala-->Pro] is a mildly unstable variant, associated with hemolytic anemia, marked microcytosis and increased alpha/beta biosynthetic ratio (1.55 versus 1.1 +/- 0.1 in the control).	Proline	39-42	amyloid beta precursor protein	Homo sapiens	9-10
11300350-1	2001	Hb Mont Saint-Aignan [beta128(H6)Ala-->Pro] is a mildly unstable variant, associated with hemolytic anemia, marked microcytosis and increased alpha/beta biosynthetic ratio (1.55 versus 1.1 +/- 0.1 in the control).	Proline	39-42	amyloid beta precursor protein	Homo sapiens	142-152
11173529-5	2001	To examine the functional significance of the PR in mitochondrial P450s, we expressed human P450c27 (CYP27) and bovine P450scc (CYP11A1) in an Escherichia coli heterologous expression system, and found that in each one specific proline residue is important for correct folding.	Proline	228-235	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	128-135
11741525-3	2001	Collagen synthesis stimulated with serum and transforming growth factor beta1 (TGF-beta1) was determined by [3H]proline incorporation.	Proline	112-119	transforming growth factor, beta 1	Rattus norvegicus	45-77
11741525-3	2001	Collagen synthesis stimulated with serum and transforming growth factor beta1 (TGF-beta1) was determined by [3H]proline incorporation.	Proline	112-119	transforming growth factor, beta 1	Rattus norvegicus	79-88
11158059-7	2001	Moreover, CM derived from hPTTG transfectants harboring a point mutation on the C-terminus proline-rich region of PTTG induced weaker angiogenic activity than WT-hPTTG-CM (P &lt; 0.01).	Proline	91-98	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	26-31
11158059-7	2001	Moreover, CM derived from hPTTG transfectants harboring a point mutation on the C-terminus proline-rich region of PTTG induced weaker angiogenic activity than WT-hPTTG-CM (P &lt; 0.01).	Proline	91-98	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	27-31
11160862-1	2001	The NAD(P)H:quinone oxidoreductase 1 (NQO1)*2 polymorphism is characterized by a single proline-to-serine amino acid substitution.	Proline	88-95	NAD(P)H dehydrogenase [quinone] 1	Oryctolagus cuniculus	4-36
11160862-1	2001	The NAD(P)H:quinone oxidoreductase 1 (NQO1)*2 polymorphism is characterized by a single proline-to-serine amino acid substitution.	Proline	88-95	NAD(P)H dehydrogenase [quinone] 1	Oryctolagus cuniculus	38-42
11178875-2	2001	Shank contains multiple domains for protein-protein interactions, including ankyrin repeats, SH3 domain, PDZ domain, SAM domain, and an extensive proline-rich region.	Proline	146-153	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	0-5
11819731-14	2001	RESULTS: In animal experiment, the pathological fibrosis scores and liver hydroxyl proline content were found to be significantly lower in rats treated with different doses of IFN-gamma as compared with rats in fibrotic model group induced by either CCl4 or DMN, in a dose-dependent manner.	Proline	83-90	interferon gamma	Rattus norvegicus	176-185
11158584-5	2001	Aqy2p from Saccharomyces chevalieri has a single amino acid in the third transmembrane domain (Ser-141) that differs from Sigma1278b Aqy2p (Pro-141).	Proline	140-143	Aqy2p	Saccharomyces cerevisiae S288C	0-5
11158584-5	2001	Aqy2p from Saccharomyces chevalieri has a single amino acid in the third transmembrane domain (Ser-141) that differs from Sigma1278b Aqy2p (Pro-141).	Proline	140-143	Aqy2p	Saccharomyces cerevisiae S288C	133-138
11819731-16	2001	Hydroxyl proline contents were 2.83 +/- 1.18, 3.59 +/- 1.22 and 4.80 +/- 1.62, in the three IFN-gamma groups, and 10.01 +/- 3.23 in fibrotic model group.	Proline	9-16	interferon gamma	Homo sapiens	92-101
11180458-7	2001	The activities of arginine (Can1p), proline (Put4p) and general amino acid permease (Gap1p) are decreased more than 20-fold.	Proline	36-43	proline permease PUT4	Saccharomyces cerevisiae S288C	45-50
11819731-20	2001	Hydroxyl proline contents were 2.72 +/- 0.58, 3.14 +/- 0.71 and 3.62 +/- 1.02, in the three IFN-gamma groups, and 12.79 +/- 1.54 in fibrotic model group.	Proline	9-16	interferon gamma	Homo sapiens	92-101
11180458-7	2001	The activities of arginine (Can1p), proline (Put4p) and general amino acid permease (Gap1p) are decreased more than 20-fold.	Proline	36-43	amino acid permease GAP1	Saccharomyces cerevisiae S288C	85-90
11054411-7	2001	PRH also contains an N-terminal proline-rich repression domain that is separate from the homeodomain.	Proline	32-39	hematopoietically expressed homeobox	Homo sapiens	0-3
11231015-0	2001	Intermolecular interactions between the SH3 domain and the proline-rich TH region of Bruton"s tyrosine kinase.	Proline	59-66	Bruton tyrosine kinase	Homo sapiens	85-109
11162102-9	2001	Two of these residues are conserved and have been shown to interact with the proline residue of the substrate in hPin1.	Proline	77-84	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	113-118
11231015-1	2001	The SH3 domain of Bruton"s tyrosine kinase (Btk) is preceded by the Tec homology (TH) region containing proline-rich sequences.	Proline	104-111	Bruton tyrosine kinase	Homo sapiens	18-42
11231015-1	2001	The SH3 domain of Bruton"s tyrosine kinase (Btk) is preceded by the Tec homology (TH) region containing proline-rich sequences.	Proline	104-111	Bruton tyrosine kinase	Homo sapiens	44-47
11170382-8	2001	In this framework, we suggest that (1) in the actin-myosin association phase, cationic residues Lys-576 and Lys-578 interact with anionic residues of the so-called second actin, and (2) in the product leaving phase, hydrophobic residues Trp-546, Phe-547, and Pro-548, as well as the Thr-532/Asn-533/Pro-534/Pro-535 sequence, sever connections with the so-called first actin.	Proline	259-262	myosin heavy chain 14	Homo sapiens	52-58
11162806-3	2001	Conserved features in all AHSV NS3 proteins include the synthesis of a truncated NS3A protein from the same open reading frame as that of NS3, a proline-rich region, a region of strict sequence conservation and two hydrophobic domains.	Proline	145-152	KRAS proto-oncogene, GTPase	Homo sapiens	31-34
11170382-8	2001	In this framework, we suggest that (1) in the actin-myosin association phase, cationic residues Lys-576 and Lys-578 interact with anionic residues of the so-called second actin, and (2) in the product leaving phase, hydrophobic residues Trp-546, Phe-547, and Pro-548, as well as the Thr-532/Asn-533/Pro-534/Pro-535 sequence, sever connections with the so-called first actin.	Proline	299-302	myosin heavy chain 14	Homo sapiens	52-58
11170382-8	2001	In this framework, we suggest that (1) in the actin-myosin association phase, cationic residues Lys-576 and Lys-578 interact with anionic residues of the so-called second actin, and (2) in the product leaving phase, hydrophobic residues Trp-546, Phe-547, and Pro-548, as well as the Thr-532/Asn-533/Pro-534/Pro-535 sequence, sever connections with the so-called first actin.	Proline	299-302	myosin heavy chain 14	Homo sapiens	52-58
11050083-8	2001	Rac1N17 also inhibited HSF activation by l-azetidine-2-carboxylic acid, a proline analog, and heavy metals (CdCl)), suggesting that Rac1 may be linked to HSF activation by denaturation of polypeptides in response to various proteotoxic stresses.	Proline	74-81	interleukin 6	Homo sapiens	23-26
11050083-8	2001	Rac1N17 also inhibited HSF activation by l-azetidine-2-carboxylic acid, a proline analog, and heavy metals (CdCl)), suggesting that Rac1 may be linked to HSF activation by denaturation of polypeptides in response to various proteotoxic stresses.	Proline	74-81	Rac family small GTPase 1	Homo sapiens	0-4
11050083-8	2001	Rac1N17 also inhibited HSF activation by l-azetidine-2-carboxylic acid, a proline analog, and heavy metals (CdCl)), suggesting that Rac1 may be linked to HSF activation by denaturation of polypeptides in response to various proteotoxic stresses.	Proline	74-81	interleukin 6	Homo sapiens	154-157
11149959-2	2001	Here, we show that Src-family protein tyrosine kinases (PTKs) bind to heteromultimeric Shaker-family voltage-gated potassium (Kv) channels by interactions between the Src homology 3 (SH3) domain and the proline-rich SH3 domain ligand sequence in the Shaker-family subunit Kv1.5.	Proline	203-210	potassium voltage-gated channel subfamily A member 5	Homo sapiens	272-277
11170638-8	2001	The correlation of the smaller distance with activity at the B1 receptor is in complete accord with the results from our previous examination of Lys-Arg-NH-(CH(2))(11)-CO-Ser-Pro-Phe.	Proline	175-178	bradykinin receptor B1	Homo sapiens	61-72
11149959-3	2001	Once bound to Kv1.5, Src-family PTKs phosphorylate adjacent subunits in the Kv channel heteromultimer that lack proline-rich SH3 domain ligand sequences.	Proline	112-119	potassium voltage-gated channel subfamily A member 5	Homo sapiens	14-19
11042168-7	2001	The regions of AGS3 that bound Galpha(i) were localized to four amino acid repeats (G-protein regulatory motif (GPR)) in the carboxyl terminus (Pro(463)-Ser(650)), each of which were capable of binding Galpha(i).	Proline	144-147	G protein signaling modulator 1	Homo sapiens	15-19
11162505-2	2001	In the cytoplasmic domain of S4C there is a proline-rich region suggesting that the cytoplasmic domain may play an important role in Sema4C function.	Proline	44-51	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	Mus musculus	29-32
11162505-2	2001	In the cytoplasmic domain of S4C there is a proline-rich region suggesting that the cytoplasmic domain may play an important role in Sema4C function.	Proline	44-51	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	Mus musculus	133-139
11013245-0	2001	p13(SUC1) and the WW domain of PIN1 bind to the same phosphothreonine-proline epitope.	Proline	70-77	H3 histone pseudogene 6	Homo sapiens	0-3
11013245-0	2001	p13(SUC1) and the WW domain of PIN1 bind to the same phosphothreonine-proline epitope.	Proline	70-77	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	31-35
11042168-7	2001	The regions of AGS3 that bound Galpha(i) were localized to four amino acid repeats (G-protein regulatory motif (GPR)) in the carboxyl terminus (Pro(463)-Ser(650)), each of which were capable of binding Galpha(i).	Proline	144-147	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	31-37
11013245-4	2001	The epitope recognized by p13(SUC1) includes the proline at position +1 of the phosphothreonine, as was shown by the decrease in affinity for a mutated CDC25 phosphopeptide, containing an alanine/proline substitution.	Proline	49-56	H3 histone pseudogene 6	Homo sapiens	26-29
11013245-4	2001	The epitope recognized by p13(SUC1) includes the proline at position +1 of the phosphothreonine, as was shown by the decrease in affinity for a mutated CDC25 phosphopeptide, containing an alanine/proline substitution.	Proline	196-203	H3 histone pseudogene 6	Homo sapiens	26-29
11313946-2	2001	This Ras pathway modulator (RPM), also termed RGL3, exhibited Ras-binding and catalytic domains typical of the RalGDS-family of guanine nucleotide exchange factors, and was most similar to Rlf (RalGDS-like factor), but was distinguished by a unique proline-rich region with multiple candidate SH3-domain binding sites.	Proline	249-256	ral guanine nucleotide dissociation stimulator like 3	Homo sapiens	46-50
11313946-2	2001	This Ras pathway modulator (RPM), also termed RGL3, exhibited Ras-binding and catalytic domains typical of the RalGDS-family of guanine nucleotide exchange factors, and was most similar to Rlf (RalGDS-like factor), but was distinguished by a unique proline-rich region with multiple candidate SH3-domain binding sites.	Proline	249-256	ral guanine nucleotide dissociation stimulator like 2	Homo sapiens	194-212
11669337-10	2001	A common polymorphism in p53 at codon 72 (arginine/proline) was found in 6/8 of the patients.	Proline	51-58	tumor protein p53	Homo sapiens	25-28
11137854-4	2001	Prolidase [EC 3.4.13.9] cleaves imidodipeptides containing C-terminal proline, providing large amount of proline for collagen synthesis.	Proline	70-77	peptidase D	Homo sapiens	0-9
11137854-4	2001	Prolidase [EC 3.4.13.9] cleaves imidodipeptides containing C-terminal proline, providing large amount of proline for collagen synthesis.	Proline	105-112	peptidase D	Homo sapiens	0-9
11174479-1	2001	OBJECTIVE: It has recently been suggested that white women who are homozygous for the allele of the gene for wild-type p53 protein (TP53) that encodes arginine at position 72 are more susceptible to human papillomavirus-associated cervical carcinoma than are women who are heterozygous for this polymorphism and women who are homozygous for the allele that encodes proline at that position.	Proline	365-372	tumor protein p53	Homo sapiens	119-122
11174479-1	2001	OBJECTIVE: It has recently been suggested that white women who are homozygous for the allele of the gene for wild-type p53 protein (TP53) that encodes arginine at position 72 are more susceptible to human papillomavirus-associated cervical carcinoma than are women who are heterozygous for this polymorphism and women who are homozygous for the allele that encodes proline at that position.	Proline	365-372	tumor protein p53	Homo sapiens	132-136
11726031-3	2001	TRX is a small ubiquitous protein with the redox-active site sequence -Cys-Gly-Pro-Cys-.	Proline	79-82	thioredoxin	Homo sapiens	0-3
11120661-0	2001	Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells.	Proline	69-76	arginase 1	Bos taurus	19-29
11120661-11	2001	Our results indicate that arginase expression can modulate NO synthesis in bovine venular EC and that basal levels of arginase I and II are limiting for endothelial syntheses of polyamines, proline, and glutamate and may have important implications for wound healing, angiogenesis, and cardiovascular function.	Proline	190-197	arginase 1	Bos taurus	118-135
11803605-5	2001	In 175 HTx pts and 268 controls, polymorphism in the signal peptide of the TGF beta gene, substitution of leucine-proline at codon 10 and arginine-proline at codon 25, was evaluated by PCR.	Proline	114-121	transforming growth factor beta 1	Homo sapiens	75-83
11211934-5	2001	Different from most other synaptotagmins, however, synaptotagmin 13 does not have an N-terminal sequence preceding the transmembrane region, and features an unusually long connecting sequence that is proline-rich.	Proline	200-207	synaptotagmin 13	Homo sapiens	51-67
11543693-8	2001	Lowered serum activity of prolyl endopeptidase (PEP), a cytosolic endopeptidase that cleaves peptide bonds on the carboxyl side of proline in proteins of relatively small molecular mass, may play a role in the biophysiology of fibromyalgia through diminished inactivation of algesic and depression-related peptides, e.g. substance P.	Proline	131-138	prolyl endopeptidase	Homo sapiens	26-46
11543693-8	2001	Lowered serum activity of prolyl endopeptidase (PEP), a cytosolic endopeptidase that cleaves peptide bonds on the carboxyl side of proline in proteins of relatively small molecular mass, may play a role in the biophysiology of fibromyalgia through diminished inactivation of algesic and depression-related peptides, e.g. substance P.	Proline	131-138	prolyl endopeptidase	Homo sapiens	48-51
11072226-0	2001	NMR studies of adrenocorticotropin hormone peptides in sodium dodecylsulfate and dodecylphosphocholine micelles: proline isomerism and interactions of the peptides with micelles.	Proline	113-120	proopiomelanocortin	Homo sapiens	15-42
11604102-3	2001	DAZAP1 contains two RNA-binding domains (RBDs) and a proline-rich C-terminal portion, and is expressed most abundantly in the testis.	Proline	53-60	DAZ associated protein 1	Mus musculus	0-6
11220626-1	2001	Here we describe a hitherto unknown proline/threonine polymorphism at residue 72 of the human IgG2 CH1 domain (EU numbering 189) and show that it is linked to the known valine/methionine polymorphism at residue 52 of CH2 (EU numbering 282) defining the G2m(n+)/G2m(n-) allotypes.	Proline	36-43	SUN domain containing ossification factor	Homo sapiens	99-102
11820611-2	2001	Prolidase evokes the ability to hydrolyse the imido-bond of various low molecular weight compounds coupled to L-proline.	Proline	110-119	peptidase D	Homo sapiens	0-9
11820611-4	2001	Treatment of these prodrugs with prolidase generated L-proline and the free drug, demonstrating their substrate susceptibility prolidase.	Proline	53-62	peptidase D	Homo sapiens	33-42
11820611-4	2001	Treatment of these prodrugs with prolidase generated L-proline and the free drug, demonstrating their substrate susceptibility prolidase.	Proline	53-62	peptidase D	Homo sapiens	127-136
11820612-0	2001	Proline analogue of melphalan as a prolidase-convertible pro-drug in breast cancer MCF-7 cells.	Proline	0-7	peptidase D	Homo sapiens	35-44
11820612-1	2001	Prolidase [E.C.3.4.13.9] is ubiquitously distributed cytosolic egzopeptidase that is known to cleave imido-bond of some low molecular weight compounds coupled to L-proline.	Proline	162-171	peptidase D	Homo sapiens	0-9
11820612-2	2001	Previously we have found that conjugation of antineoplastic drug--melphalan (Mel) with proline (pro) through imido-bond resulted in formation of a good substrate for purified prolidase.	Proline	87-94	peptidase D	Homo sapiens	175-184
11820612-2	2001	Previously we have found that conjugation of antineoplastic drug--melphalan (Mel) with proline (pro) through imido-bond resulted in formation of a good substrate for purified prolidase.	Proline	87-90	peptidase D	Homo sapiens	175-184
11820612-3	2001	Cytosolic location of prolidase in neoplastic cells suggests that proline analogue of melphalan (Mel-pro) may serve as a prolidase convertable pro-drug.	Proline	66-73	peptidase D	Homo sapiens	22-31
11136713-0	2001	The destabilization of human GCAP1 by a proline to leucine mutation might cause cone-rod dystrophy.	Proline	40-47	guanylate cyclase activator 2A	Homo sapiens	29-34
11136713-2	2001	In this paper, experimentally derived observations are reported that help in explaining why a proline--&gt;leucine mutation at position 50 of human GCAP1 results in cone-rod dystrophy in a family carrying this mutation.	Proline	94-101	guanylate cyclase activator 2A	Homo sapiens	148-153
11820612-3	2001	Cytosolic location of prolidase in neoplastic cells suggests that proline analogue of melphalan (Mel-pro) may serve as a prolidase convertable pro-drug.	Proline	66-73	peptidase D	Homo sapiens	121-130
11220626-3	2001	Proline 72 in CH1 of G2m(n-) is changed to threonine in the G2m(n+) [G2m(23)] allotype.	Proline	0-7	SUN domain containing ossification factor	Homo sapiens	14-17
11746515-6	2001	In addition, we propose that the two-proline residues in the WPD loop (Pro(420) and Pro(425) in SHP-1) work as pivotal points through a conserved hydrophobic network and allows residues between the pivotal points to have maximum flexibility in enhancing the phosphatase activity.	Proline	37-44	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	96-101
11147807-8	2001	Northern blotting of the nontransformed and the M-gamma-A-transformed 22574d cells with gene-specific probes for the three proline transporters showed the expression of an mRNA for UGA4 in both transformed and nontransformed cells but no evidence for the expression of GAP1 or PUT4.	Proline	123-130	Uga4p	Saccharomyces cerevisiae S288C	181-185
11746515-6	2001	In addition, we propose that the two-proline residues in the WPD loop (Pro(420) and Pro(425) in SHP-1) work as pivotal points through a conserved hydrophobic network and allows residues between the pivotal points to have maximum flexibility in enhancing the phosphatase activity.	Proline	71-74	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	96-101
11746524-2	2001	The SH2 domain of Grb2 recognizes and interacts with phosphotyrosine residues on activated tyrosine kinases, whereas the SH3 domains bind to several proline-rich domain-containing proteins such as Sos1.	Proline	149-156	growth factor receptor bound protein 2	Homo sapiens	18-22
11746515-6	2001	In addition, we propose that the two-proline residues in the WPD loop (Pro(420) and Pro(425) in SHP-1) work as pivotal points through a conserved hydrophobic network and allows residues between the pivotal points to have maximum flexibility in enhancing the phosphatase activity.	Proline	84-87	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	96-101
11746524-2	2001	The SH2 domain of Grb2 recognizes and interacts with phosphotyrosine residues on activated tyrosine kinases, whereas the SH3 domains bind to several proline-rich domain-containing proteins such as Sos1.	Proline	149-156	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	197-201
11746526-4	2001	We mapped the rasGAP(120) interactive region of the G3BP-2 isoforms and show that both G3BP-2a and G3BP-2b use an N-terminal NTF2-like domain for rasGAP(120) binding rather than several available proline-rich (PxxP) motifs found in members of the G3BPs.	Proline	196-203	GTPase activating protein (SH3 domain) binding protein 1	Mus musculus	87-91
11723825-1	2001	Elastin is the main protein of elastic fibers and confers the property of elastic recoil to the tissues such as arteries, lung, elastic cartilage,... Elastin synthesis goes through several steps: gene transcription, alternative splicing of pre-mRNA, mRNA translation, hydroxylation of some proline residues of the newly synthesized protein-tropoelastin-, association of with a 67 kDa chaperone protein, secretion of tropoelastin molecules in the extracellular space, and their deposition on the microfibrillar scaffold which contains fibrillin 1, fibrillin 2, MAGP 1 and MAGP 2,.... After the synthesis of cross-links-lysinonorleucine, desmosine, isodesmosine-, elastin becomes insoluble and elastic.	Proline	290-297	elastin	Homo sapiens	0-7
11393538-4	2001	We found one novel polymorphism, a substitution of Ala by Pro at codon 185 (GCC to CCC), in exon 5 of the AHRR gene; among 108 healthy unrelated Japanese women, genotypes Ala/Ala, Ala/Pro, and Pro/Pro were represented, respectively, by 20 (18.5%), 49 (45.4%), and 39 (36.1%) individuals.	Proline	58-61	aryl hydrocarbon receptor repressor	Homo sapiens	106-110
11393538-4	2001	We found one novel polymorphism, a substitution of Ala by Pro at codon 185 (GCC to CCC), in exon 5 of the AHRR gene; among 108 healthy unrelated Japanese women, genotypes Ala/Ala, Ala/Pro, and Pro/Pro were represented, respectively, by 20 (18.5%), 49 (45.4%), and 39 (36.1%) individuals.	Proline	184-187	aryl hydrocarbon receptor repressor	Homo sapiens	106-110
11723825-1	2001	Elastin is the main protein of elastic fibers and confers the property of elastic recoil to the tissues such as arteries, lung, elastic cartilage,... Elastin synthesis goes through several steps: gene transcription, alternative splicing of pre-mRNA, mRNA translation, hydroxylation of some proline residues of the newly synthesized protein-tropoelastin-, association of with a 67 kDa chaperone protein, secretion of tropoelastin molecules in the extracellular space, and their deposition on the microfibrillar scaffold which contains fibrillin 1, fibrillin 2, MAGP 1 and MAGP 2,.... After the synthesis of cross-links-lysinonorleucine, desmosine, isodesmosine-, elastin becomes insoluble and elastic.	Proline	290-297	elastin	Homo sapiens	150-157
11727705-5	2001	It is particularly true for human tropoelastin, because its sequence is rich in glycines and prolines, and these residues are frequently met in beta-turns (a beta-turn is made of four consecutive residues which are stabilized by an hydrogen bond).	Proline	93-101	elastin	Homo sapiens	34-46
11744243-3	2001	An antibody (305) that selectively recognizes a phosphorylated epitope in a proline-rich region of the MAP2 molecule has been used to analyze neocortical biopsy samples from temporal lobe epileptic patients, whose electrocorticogram activity had been previously monitored.	Proline	76-83	microtubule associated protein 2	Homo sapiens	103-107
22061172-5	2001	Maximum activity was reached at pH 5.5 and 65 C. Those synthetic substrates containing Pro in N-penultimate position were the most efficiently hydrolysed, whereas in the case of peptides, DPP II efficiently hydrolysed both X-Pro- and X-Ala- peptides.	Proline	87-90	dipeptidyl peptidase 7	Homo sapiens	188-194
11326318-9	2001	Since the region in Bcl-2 containing serine 70 and serine 87 represents a proline-rich loop that has been associated with autorepression of its antiapoptotic activity, the discovery of Pin1 interactions with phosphorylated Bcl-2 raises the possibility that Pin1 alters the conformation of Bcl-2 and thereby modulates its function in cells arrested with antimicrotubule drugs.	Proline	74-81	BCL2 apoptosis regulator	Homo sapiens	20-25
11326318-9	2001	Since the region in Bcl-2 containing serine 70 and serine 87 represents a proline-rich loop that has been associated with autorepression of its antiapoptotic activity, the discovery of Pin1 interactions with phosphorylated Bcl-2 raises the possibility that Pin1 alters the conformation of Bcl-2 and thereby modulates its function in cells arrested with antimicrotubule drugs.	Proline	74-81	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	185-189
11134285-2	2001	The ectodomain of havcr-1 contains an N-terminal immunoglobulin-like cysteine-rich region (D1), which binds protective monoclonal antibody (MAb) 190/4, followed by an O-glycosylated mucin-like threonine-serine-proline-rich region that extends D1 well above the cell surface.	Proline	210-217	hepatitis A virus cellular receptor 1	Homo sapiens	18-25
11134285-2	2001	The ectodomain of havcr-1 contains an N-terminal immunoglobulin-like cysteine-rich region (D1), which binds protective monoclonal antibody (MAb) 190/4, followed by an O-glycosylated mucin-like threonine-serine-proline-rich region that extends D1 well above the cell surface.	Proline	210-217	leiomodin 1	Homo sapiens	91-93
10913687-11	2001	Moreover, this finding of a concomitant regulation further emphasizes the concept of secretogranin II/pro-secretoneurin being a neuropeptide precursor from which the functional peptide secretoneurin is proteolytically liberated.	Proline	102-105	secretogranin II	Homo sapiens	85-101
10913687-11	2001	Moreover, this finding of a concomitant regulation further emphasizes the concept of secretogranin II/pro-secretoneurin being a neuropeptide precursor from which the functional peptide secretoneurin is proteolytically liberated.	Proline	102-105	secretogranin II	Homo sapiens	106-119
10913687-11	2001	Moreover, this finding of a concomitant regulation further emphasizes the concept of secretogranin II/pro-secretoneurin being a neuropeptide precursor from which the functional peptide secretoneurin is proteolytically liberated.	Proline	102-105	secretogranin II	Homo sapiens	185-198
11525380-6	2001	Structural analyses reveal that iPLA2beta contains unique structural features that include a serine lipase consensus motif (GXSXG), a putative ATP-binding domain, an ankyrin-repeat domain, a caspase-3 cleavage motif DVTD138Y/N, a bipartite nuclear localization signal sequence, and a proline-rich region in the human long isoform.	Proline	284-291	phospholipase A2 group VI	Homo sapiens	32-41
11843266-0	2001	Relationship between plasma cyclo (His-Pro), a neuropeptide common to processed protein-rich food, and C-peptide/insulin molar ratio in obese women.	Proline	39-42	insulin	Homo sapiens	103-112
11843266-0	2001	Relationship between plasma cyclo (His-Pro), a neuropeptide common to processed protein-rich food, and C-peptide/insulin molar ratio in obese women.	Proline	39-42	insulin	Homo sapiens	113-120
11007795-1	2000	PRELP (proline, arginine-rich end leucine-rich repeat protein) is an extracellular matrix leucine-rich repeat protein.	Proline	7-14	proline and arginine rich end leucine rich repeat protein	Homo sapiens	0-5
11157142-2	2001	METHODS: Granzyme B was added to [(3)H]proline/[(35)S]sulphate-labelled cartilage matrices and to cartilage explants.	Proline	39-46	granzyme B	Homo sapiens	9-19
11070331-1	2001	The aim of this study was to examine whether anorexia and bulimia nervosa are accompanied by lower serum activity of prolyl endopeptidase (PEP;EC 3.4.21.26; post-proline cleaving enzyme), a cytosolic endopeptidase which cleaves peptide bonds on the carboxyl side of proline in proteins of relatively small molecular mass.	Proline	162-169	prolyl endopeptidase	Homo sapiens	117-137
11070331-1	2001	The aim of this study was to examine whether anorexia and bulimia nervosa are accompanied by lower serum activity of prolyl endopeptidase (PEP;EC 3.4.21.26; post-proline cleaving enzyme), a cytosolic endopeptidase which cleaves peptide bonds on the carboxyl side of proline in proteins of relatively small molecular mass.	Proline	266-273	prolyl endopeptidase	Homo sapiens	117-137
11016931-12	2000	Binding studies of DBP to homo-oligonucleotides showed an inability of the proline mutants to bind to poly(dA)(40), indicating an inability to adapt to specific DNA conformations.	Proline	75-82	zinc finger protein 763	Homo sapiens	19-22
11007795-1	2000	PRELP (proline, arginine-rich end leucine-rich repeat protein) is an extracellular matrix leucine-rich repeat protein.	Proline	7-14	nyctalopin	Homo sapiens	34-61
11007795-1	2000	PRELP (proline, arginine-rich end leucine-rich repeat protein) is an extracellular matrix leucine-rich repeat protein.	Proline	7-14	nyctalopin	Homo sapiens	90-117
11007795-2	2000	The amino-terminal region of PRELP differs from that of other leucine-rich repeat proteins in containing a high number of proline and arginine residues.	Proline	122-129	proline and arginine rich end leucine rich repeat protein	Homo sapiens	29-34
11007795-3	2000	The clustered proline and basic residues are conserved in rat, bovine, and human PRELP.	Proline	14-21	proline and arginine rich end leucine rich repeat protein	Homo sapiens	81-86
11123894-4	2000	Human MMP-9 has three potential N-linked glycosylation sites and contains a Ser/Pro/Thr rich domain, known as the type V collagen-like domain, which is expected to be heavily O-glycosylated.	Proline	80-83	matrix metallopeptidase 9	Homo sapiens	6-11
11120828-2	2000	In all animal species thus far studied, anti-Sm Abs initially recognize proline-rich epitopes in the carboxyl terminus of the Sm-B/B" protein and subsequently to multiple other epitopes in B/B" and D. The absence of appropriate mAbs has limited our understanding of the genetic and structural basis of this autoimmune response.	Proline	72-79	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	126-132
11146101-5	2000	Using the yeast two-hybrid system and the in vitro GST pull-down assay, we found that the N-terminal proline/serine rich (PS) domain of ULK1 (amino acid 287-416) is required for ULK1-GATE-16 and ULK1-GABARAP protein interactions.	Proline	101-108	unc-51 like autophagy activating kinase 1	Homo sapiens	136-140
11146101-5	2000	Using the yeast two-hybrid system and the in vitro GST pull-down assay, we found that the N-terminal proline/serine rich (PS) domain of ULK1 (amino acid 287-416) is required for ULK1-GATE-16 and ULK1-GABARAP protein interactions.	Proline	101-108	GABA type A receptor associated protein like 2	Homo sapiens	183-190
11146101-5	2000	Using the yeast two-hybrid system and the in vitro GST pull-down assay, we found that the N-terminal proline/serine rich (PS) domain of ULK1 (amino acid 287-416) is required for ULK1-GATE-16 and ULK1-GABARAP protein interactions.	Proline	101-108	GABA type A receptor-associated protein	Homo sapiens	200-207
11104699-4	2000	The interaction is direct, specific, and involves the N-terminal proline-rich region in the cytoplasmic tail of ADAM 12 and the Src homology 3 (SH3) domain of Src.	Proline	65-72	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	Mus musculus	112-119
11104699-4	2000	The interaction is direct, specific, and involves the N-terminal proline-rich region in the cytoplasmic tail of ADAM 12 and the Src homology 3 (SH3) domain of Src.	Proline	65-72	Rous sarcoma oncogene	Mus musculus	128-131
11104699-4	2000	The interaction is direct, specific, and involves the N-terminal proline-rich region in the cytoplasmic tail of ADAM 12 and the Src homology 3 (SH3) domain of Src.	Proline	65-72	Rous sarcoma oncogene	Mus musculus	159-162
10991943-5	2000	A strong interaction between the TIMP-2 C domain (Glu(153)-Pro(221)) and the gelatinase A hemopexin C domain (Gly(446)-Cys(660)) was demonstrated by the yeast two-hybrid system.	Proline	59-62	TIMP metallopeptidase inhibitor 2	Homo sapiens	33-39
11118382-4	2000	With the Gag-Pro-expressing construct, we observed HTLV-I-specific cytoplasmic proteolysis of the Gag precursor, but again no particle released in the culture supernatants.	Proline	13-16	Pr55	Human T-cell leukemia virus type I	9-12
11118382-4	2000	With the Gag-Pro-expressing construct, we observed HTLV-I-specific cytoplasmic proteolysis of the Gag precursor, but again no particle released in the culture supernatants.	Proline	13-16	Pr55	Human T-cell leukemia virus type I	98-101
11112430-2	2000	We previously identified a novel Sec23p-interacting protein, p125, which consists of 1000 amino acids and comprises a proline-rich region and a phospholipase A(1) homology region.	Proline	118-125	SEC23 interacting protein	Homo sapiens	61-65
11118637-5	2000	Two other variants of CAS that contained deletions of either the SH3 domain alone, or the SH3 domain together with an adjoining proline-rich region, also retained the capacity to localize to focal adhesions.	Proline	128-135	BCAR1 scaffold protein, Cas family member	Homo sapiens	22-25
11112430-7	2000	For the correct localization of p125, a region (residues 135-1000) comprising both the proline-rich and phospholipase A(1) homology regions was required.	Proline	87-94	SEC23 interacting protein	Homo sapiens	32-36
11106831-11	2000	The mutation on exon 5 was identified as a substitution of CCT (proline) for CTT (leucine) at codon 164, which has never been reported before.	Proline	64-71	CCT	Homo sapiens	59-62
11095718-5	2000	A combination of genetics and sequencing identified a proline to serine mutation (P299S) in the gene coding for the glutamate-gated chloride channel subunit DmGluClalpha.	Proline	54-61	GluClalpha	Drosophila melanogaster	157-169
11144701-7	2000	DATA SYNTHESIS: Insulin aspart, the second Food and Drug Administration-approved rapid-acting insulin analog, is produced by recombinant technology that replaces the proline at position 28 on the B chain of insulin with negatively charged aspartic acid.	Proline	166-173	insulin	Homo sapiens	16-23
11144701-7	2000	DATA SYNTHESIS: Insulin aspart, the second Food and Drug Administration-approved rapid-acting insulin analog, is produced by recombinant technology that replaces the proline at position 28 on the B chain of insulin with negatively charged aspartic acid.	Proline	166-173	insulin	Homo sapiens	207-214
11082044-3	2000	PACSIN 3 differs from the other family members in having a short proline-rich region and lacking asparagine-proline-phenylalanine motifs.	Proline	65-72	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	0-8
11095640-4	2000	Point mutational analysis reveals that a proline-rich motif (PXXPXXP) within this region is the site of ANKRA binding.	Proline	41-48	ankyrin repeat family A member 2	Homo sapiens	104-109
11190469-0	2000	[Effect of mutations in PHO85 and PHO4 genes on utilization of proline in Saccharomyces cerevisiae yeasts].	Proline	63-70	cyclin-dependent serine/threonine-protein kinase PHO85	Saccharomyces cerevisiae S288C	24-29
11190469-0	2000	[Effect of mutations in PHO85 and PHO4 genes on utilization of proline in Saccharomyces cerevisiae yeasts].	Proline	63-70	phosphate-sensing transcription factor PHO4	Saccharomyces cerevisiae S288C	34-38
11190469-5	2000	The Pho4p protein that activates transcription of the PH05 gene, a structural gene of acid phosphatase, seems to participate in the negative regulation of the PUT1 and PUT2 genes encoding enzymes of proline catabolism, proline oxidase and delta-pyrroline-5-carboxylate dehydrogenase.	Proline	199-206	phosphate-sensing transcription factor PHO4	Saccharomyces cerevisiae S288C	4-9
11190469-5	2000	The Pho4p protein that activates transcription of the PH05 gene, a structural gene of acid phosphatase, seems to participate in the negative regulation of the PUT1 and PUT2 genes encoding enzymes of proline catabolism, proline oxidase and delta-pyrroline-5-carboxylate dehydrogenase.	Proline	199-206	proline dehydrogenase	Saccharomyces cerevisiae S288C	159-163
11190469-5	2000	The Pho4p protein that activates transcription of the PH05 gene, a structural gene of acid phosphatase, seems to participate in the negative regulation of the PUT1 and PUT2 genes encoding enzymes of proline catabolism, proline oxidase and delta-pyrroline-5-carboxylate dehydrogenase.	Proline	199-206	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	168-172
11082044-3	2000	PACSIN 3 differs from the other family members in having a short proline-rich region and lacking asparagine-proline-phenylalanine motifs.	Proline	108-115	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	0-8
11115899-5	2000	Moreover, we show that it results in multiple biochemical changes associated with cold acclimation: CBF3-expressing plants had elevated levels of proline (Pro) and total soluble sugars, including sucrose, raffinose, glucose, and fructose.	Proline	146-153	dehydration response element B1A	Arabidopsis thaliana	100-104
11134146-9	2000	Molecular dynamics simulations suggest that substitution of L368 of the hLHR by proline results in lack of a salt bridge interaction between D405 and R464 (distance 9.	Proline	80-87	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	72-76
11094079-4	2000	The N-terminal MN1 moiety is rich in proline residues and contains two polyglutamine stretches, suggesting that MN1-TEL may act as a deregulated transcription factor.	Proline	37-44	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	15-18
11094079-4	2000	The N-terminal MN1 moiety is rich in proline residues and contains two polyglutamine stretches, suggesting that MN1-TEL may act as a deregulated transcription factor.	Proline	37-44	ETS variant transcription factor 6	Homo sapiens	116-119
11094088-1	2000	The Saccharomyces cerevisiae inositol polyphosphate 5-phosphatases (Inp51p, Inp52p, and Inp53p) each contain an N-terminal Sac1 domain, followed by a 5-phosphatase domain and a C-terminal proline-rich domain.	Proline	188-195	phosphoinositide 5-phosphatase INP51	Saccharomyces cerevisiae S288C	68-74
11094088-1	2000	The Saccharomyces cerevisiae inositol polyphosphate 5-phosphatases (Inp51p, Inp52p, and Inp53p) each contain an N-terminal Sac1 domain, followed by a 5-phosphatase domain and a C-terminal proline-rich domain.	Proline	188-195	phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52	Saccharomyces cerevisiae S288C	76-82
11094088-1	2000	The Saccharomyces cerevisiae inositol polyphosphate 5-phosphatases (Inp51p, Inp52p, and Inp53p) each contain an N-terminal Sac1 domain, followed by a 5-phosphatase domain and a C-terminal proline-rich domain.	Proline	188-195	phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53	Saccharomyces cerevisiae S288C	88-94
11094088-8	2000	Both the Sac1 domain and proline-rich domains were able to independently mediate translocation of Inp52p to actin patches, following hyperosmotic stress, while the Inp53p proline-rich domain alone was sufficient for stress-mediated localization.	Proline	25-32	phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52	Saccharomyces cerevisiae S288C	98-104
11094088-8	2000	Both the Sac1 domain and proline-rich domains were able to independently mediate translocation of Inp52p to actin patches, following hyperosmotic stress, while the Inp53p proline-rich domain alone was sufficient for stress-mediated localization.	Proline	171-178	phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53	Saccharomyces cerevisiae S288C	164-170
11070019-0	2000	Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 protein.	Proline	36-43	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	14-17
11070019-0	2000	Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 protein.	Proline	36-43	tegument protein US11	Human alphaherpesvirus 1	103-107
11070019-5	2000	We demonstrate that expression of a 68-amino-acid fragment of Us11 containing a novel proline-rich basic RNA binding domain allows for sustained protein synthesis and enhanced growth of gamma 34.5 mutants.	Proline	86-93	tegument protein US11	Human alphaherpesvirus 1	62-66
11163209-5	2000	ATF6 processing required the RxxL and asparagine/proline motifs, known requirements for S1P and S2P processing, respectively.	Proline	49-56	activating transcription factor 6	Homo sapiens	0-4
11163209-5	2000	ATF6 processing required the RxxL and asparagine/proline motifs, known requirements for S1P and S2P processing, respectively.	Proline	49-56	membrane bound transcription factor peptidase, site 1	Homo sapiens	88-91
11163209-5	2000	ATF6 processing required the RxxL and asparagine/proline motifs, known requirements for S1P and S2P processing, respectively.	Proline	49-56	membrane bound transcription factor peptidase, site 2	Homo sapiens	96-99
11115899-5	2000	Moreover, we show that it results in multiple biochemical changes associated with cold acclimation: CBF3-expressing plants had elevated levels of proline (Pro) and total soluble sugars, including sucrose, raffinose, glucose, and fructose.	Proline	155-158	dehydration response element B1A	Arabidopsis thaliana	100-104
11819703-10	2000	Increasing Ang II concentrations produced corresponding increases in (3)H-proline incorporation.	Proline	74-81	angiotensinogen	Rattus norvegicus	11-17
10948199-1	2000	A human RNase III gene encodes a protein of 160 kDa with multiple domains, a proline-rich, a serine- and arginine-rich, and an RNase III domain.	Proline	77-84	drosha ribonuclease III	Homo sapiens	8-17
11087666-2	2000	The mouse Klf13 cDNA (1310 bp in length) contains a single open reading frame of 288 amino acids with a DNA-binding domain closely related to that of the human RFLAT-1 protein and a putative transactivator N-terminal domain rich in proline and alanine residues.	Proline	232-239	Kruppel-like factor 13	Mus musculus	10-15
11069295-6	2000	Proline oxidase, a mitochondrial enzyme involved in the proline/pyrroline-5-carboxylate redox cycle, was up-regulated by p53 in ECV but not in DECV cells.	Proline	56-63	tumor protein p53	Homo sapiens	121-124
11069295-9	2000	The results directly implicate proline oxidase and the proline/P5C pathway in p53-induced growth suppression and apoptosis.	Proline	31-38	tumor protein p53	Homo sapiens	78-81
10945997-8	2000	EVL bound directly to the Abl, Lyn, and nSrc SH3 domains; the FE65 WW domain; and profilin, likely via its proline-rich core.	Proline	107-114	Enah/Vasp-like	Homo sapiens	0-3
11092761-0	2000	Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding delta(1)-pyrroline-5-carboxylate synthase.	Proline	64-71	aldehyde dehydrogenase 18 family member A1	Homo sapiens	134-175
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Proline	225-232	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-41
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Proline	225-232	aldehyde dehydrogenase 18 family member A1	Homo sapiens	43-47
11062067-2	2000	Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase (MKK)4 and MKK7.	Proline	96-99	mitogen-activated protein kinase kinase 4	Homo sapiens	198-203
11062067-2	2000	Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase (MKK)4 and MKK7.	Proline	96-99	mitogen-activated protein kinase kinase 7	Homo sapiens	208-212
11067927-0	2000	Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase.	Proline	60-67	dipeptidyl peptidase 7	Homo sapiens	95-129
11087669-4	2000	In addition, C5ORF5 contains a putative rhoGAP domain at the N-terminus, C5ORF6 has a proline-rich sequence near the N-terminus, and C5ORF7 has a zinc-finger domain that partially overlaps the NLS.	Proline	86-93	family with sequence similarity 53 member C	Homo sapiens	73-79
11114373-7	2000	Further characterization of lnk(-/-) mice also revealed that full-length Lnk is a 68 kDa protein containing a conserved proline-rich region and a PH domain.	Proline	120-127	SH2B adaptor protein 3	Mus musculus	73-76
11078884-4	2000	Furthermore, porcine [Leu(31), Pro(34)]NPY, which binds poorly to mammalian Y2, exhibited an unexpectedly high affinity for chicken Y2.	Proline	31-34	neuropeptide Y	Homo sapiens	39-42
10931822-5	2000	The proline-rich region of cain forms a stable association with the SH3 domain of amphiphysin 1.	Proline	4-11	calcineurin binding protein 1	Homo sapiens	27-31
11083269-4	2000	METHODS: Three recombinant peptides accounting for the N-terminal end, proline-rich C region, and epidermal growth factor-like calcium-binding (EGF-cb) domains of fibrillin 1 were used in a radioimmunoassay to screen sera from a large group of SSc and PM/DM patients and ethnically matched controls.	Proline	71-78	fibrillin 1	Homo sapiens	163-174
11106785-6	2000	The conserved regions of FAAH are described in terms of sequence and function, including the amidase domain which contains the serine catalytic nucleophile, the hydrophobic domain important for self association, and the proline rich domain region, which may be important for subcellular localization.	Proline	220-227	fatty acid amide hydrolase	Homo sapiens	25-29
11204951-0	2000	Prolidase-activated prodrug for cancer chemotherapy cytotoxic activity of proline analogue of chlorambucil in breast cancer MCF-7 cells.	Proline	74-81	peptidase D	Homo sapiens	0-9
11204951-2	2000	Because prolidase possesses the ability to hydrolyse imido bonds of various low molecular weight compounds coupled to L-proline, we hypothesized that coupling of L-proline through an imido bond to anticancer drugs might create prodrugs which would be locally activated by tumour-associated prolidase and consequently would be less toxic to normal cells that evoke lower prolidase activity.	Proline	118-127	peptidase D	Homo sapiens	8-17
11204951-2	2000	Because prolidase possesses the ability to hydrolyse imido bonds of various low molecular weight compounds coupled to L-proline, we hypothesized that coupling of L-proline through an imido bond to anticancer drugs might create prodrugs which would be locally activated by tumour-associated prolidase and consequently would be less toxic to normal cells that evoke lower prolidase activity.	Proline	118-127	peptidase D	Homo sapiens	290-299
11204951-2	2000	Because prolidase possesses the ability to hydrolyse imido bonds of various low molecular weight compounds coupled to L-proline, we hypothesized that coupling of L-proline through an imido bond to anticancer drugs might create prodrugs which would be locally activated by tumour-associated prolidase and consequently would be less toxic to normal cells that evoke lower prolidase activity.	Proline	118-127	peptidase D	Homo sapiens	290-299
11204951-2	2000	Because prolidase possesses the ability to hydrolyse imido bonds of various low molecular weight compounds coupled to L-proline, we hypothesized that coupling of L-proline through an imido bond to anticancer drugs might create prodrugs which would be locally activated by tumour-associated prolidase and consequently would be less toxic to normal cells that evoke lower prolidase activity.	Proline	162-171	peptidase D	Homo sapiens	8-17
11204951-2	2000	Because prolidase possesses the ability to hydrolyse imido bonds of various low molecular weight compounds coupled to L-proline, we hypothesized that coupling of L-proline through an imido bond to anticancer drugs might create prodrugs which would be locally activated by tumour-associated prolidase and consequently would be less toxic to normal cells that evoke lower prolidase activity.	Proline	162-171	peptidase D	Homo sapiens	290-299
11204951-2	2000	Because prolidase possesses the ability to hydrolyse imido bonds of various low molecular weight compounds coupled to L-proline, we hypothesized that coupling of L-proline through an imido bond to anticancer drugs might create prodrugs which would be locally activated by tumour-associated prolidase and consequently would be less toxic to normal cells that evoke lower prolidase activity.	Proline	162-171	peptidase D	Homo sapiens	290-299
11204951-4	2000	Treatment of this prodrug with prolidase generated the L-proline and the free drug, demonstrating its substrate susceptibility to prolidase.	Proline	55-64	peptidase D	Homo sapiens	31-40
11204951-4	2000	Treatment of this prodrug with prolidase generated the L-proline and the free drug, demonstrating its substrate susceptibility to prolidase.	Proline	55-64	peptidase D	Homo sapiens	130-139
11013136-6	2000	This proline, adjacent to the CxxxC copper-binding domain of SCO1, is likely to play a crucial role in the tridimentional structure of the domain.	Proline	5-12	synthesis of cytochrome C oxidase 1	Homo sapiens	61-65
11139141-6	2000	The alternative splicing occurs within the first proline-rich domain of p230.	Proline	49-56	golgin A4	Homo sapiens	72-76
11027290-3	2000	Two transcripts encode different profilin II isoforms (designated IIa and IIb) that have similar affinities for actin but different affinities for polyphosphoinositides and proline-rich sequences.	Proline	173-180	profilin 2	Homo sapiens	33-44
11071924-3	2000	SLI-1 and c-Cbl comprise an N-terminal region (termed SLI-1:N/Cbl-N, containing a four-helix bundle, an EF hand calcium-binding domain, and a divergent SH2 domain) followed by a RING finger domain and a proline-rich C-terminus.	Proline	203-210	E3 ubiquitin-protein ligase CBL	Caenorhabditis elegans	0-5
10996130-2	2000	Particular emphasis is placed upon the properties and inhibition of lysyl oxidase, the enzyme which initiates the covalent crosslinking of extracellular collagen molecules converting these to insoluble fibers, and upon the properties and inhibition of prolyl hydroxylase, the intracellular enzyme which hyroxylates proline residues within collagen.	Proline	315-322	lysyl oxidase	Homo sapiens	68-81
11007954-5	2000	By means of its SH3 domains, Grb2 recognizes proline-rich sequences of Sos, leading to Ras activation.	Proline	45-52	growth factor receptor bound protein 2	Homo sapiens	29-33
11040125-3	2000	A proline-rich region, residues 132-141, binds to the SH3 domain of the Lck protein.	Proline	2-9	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
11040125-10	2000	Tip lacking the proline-rich Lck-binding domain exhibited almost wild-type activity in this assay.	Proline	16-23	TOR signaling pathway regulator	Homo sapiens	0-3
11040125-10	2000	Tip lacking the proline-rich Lck-binding domain exhibited almost wild-type activity in this assay.	Proline	16-23	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
11045785-13	2000	In conclusion, the codon 72 germ-line polymorphism (Arg/Pro) of the common tumor suppressor gene p53 contributes to heritable susceptibility for smoke-induced lung adenocarcinoma.	Proline	56-59	tumor protein p53	Homo sapiens	97-100
11023514-7	2000	Substitution of proline with serine in the extracellular portion of IL-7R alpha did not affect IL-7R alpha messenger RNA (mRNA) and protein expression, but severely compromised affinity to IL-7, resulting in defective signal transduction.	Proline	16-23	interleukin 7 receptor	Homo sapiens	68-79
11023514-7	2000	Substitution of proline with serine in the extracellular portion of IL-7R alpha did not affect IL-7R alpha messenger RNA (mRNA) and protein expression, but severely compromised affinity to IL-7, resulting in defective signal transduction.	Proline	16-23	interleukin 7	Homo sapiens	68-72
10922375-7	2000	It is apparent that mechanisms controlling events downstream of the proline-directed MAPKs involve specific MAPK docking sites within the carboxyl termini of the MAPKAPKs that determine the cascade in which the MAPKAPK functions.	Proline	68-75	mitogen-activated protein kinase 1	Homo sapiens	85-89
11027594-8	2000	The chimeric peptide orientation (M1-M2) and the proline at position 192 of the gp46 peptide showed higher sensitivity.	Proline	49-56	serpin family H member 1	Homo sapiens	80-84
11018064-9	2000	Using a variety of biochemical methods we demonstrate that the cortactin-SH3 domain associates with the proline-rich domain (PRD) of dynamin.	Proline	104-111	cortactin	Homo sapiens	63-72
11227212-1	2000	We recently isolated and cloned an intracellular post-proline cleaving aminodipeptidase, quiescent cell proline dipeptidase (QPP), which has a substrate specificity very similar to that of dipeptidyl peptidase IV (CD26/DPPIV).	Proline	54-61	dipeptidyl peptidase 7	Homo sapiens	89-123
11227212-1	2000	We recently isolated and cloned an intracellular post-proline cleaving aminodipeptidase, quiescent cell proline dipeptidase (QPP), which has a substrate specificity very similar to that of dipeptidyl peptidase IV (CD26/DPPIV).	Proline	54-61	dipeptidyl peptidase 4	Homo sapiens	189-212
11227212-1	2000	We recently isolated and cloned an intracellular post-proline cleaving aminodipeptidase, quiescent cell proline dipeptidase (QPP), which has a substrate specificity very similar to that of dipeptidyl peptidase IV (CD26/DPPIV).	Proline	54-61	dipeptidyl peptidase 4	Homo sapiens	214-218
11227212-1	2000	We recently isolated and cloned an intracellular post-proline cleaving aminodipeptidase, quiescent cell proline dipeptidase (QPP), which has a substrate specificity very similar to that of dipeptidyl peptidase IV (CD26/DPPIV).	Proline	54-61	dipeptidyl peptidase 4	Homo sapiens	219-224
10935972-0	2000	Changes at the floor of the peptide-binding groove induce a strong preference for proline at position 3 of the bound peptide: molecular dynamics simulations of HLA-A*0217.	Proline	82-89	major histocompatibility complex, class I, A	Homo sapiens	160-165
11032808-7	2000	Src SH2 interacts with phosphotyrosine 537 of oestradiol receptor alpha and the Src SH3 domain with a proline-rich stretch of the androgen receptor.	Proline	102-109	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
11032808-7	2000	Src SH2 interacts with phosphotyrosine 537 of oestradiol receptor alpha and the Src SH3 domain with a proline-rich stretch of the androgen receptor.	Proline	102-109	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	80-83
11032808-7	2000	Src SH2 interacts with phosphotyrosine 537 of oestradiol receptor alpha and the Src SH3 domain with a proline-rich stretch of the androgen receptor.	Proline	102-109	androgen receptor	Homo sapiens	130-147
11024186-1	2000	The HMG1/2 family is a large group of proteins that share a conserved sequence of approximately 80 amino acids rich in basic, aromatic and proline side chains, referred to as an HMG box.	Proline	139-146	high mobility group box 1	Rattus norvegicus	4-10
11021990-7	2000	Furthermore, we replaced the Ile/Leu residues in the leucine zipper-like domain of Vpr with Ala or Pro and used cells that expressed the mutant protein to demonstrate that Vpr caused apoptosis in a manner that was independent of G(2) arrest.	Proline	99-102	Vpr	Human immunodeficiency virus 1	83-86
10913131-3	2000	Recruitment of Gab1 to Met or epidermal growth factor (EGF) receptors requires a receptor-binding site for the Grb2 adapter protein and a proline-rich domain in Gab1, defined as the Met-binding domain.	Proline	138-145	GRB2 associated binding protein 1	Homo sapiens	15-19
10913131-3	2000	Recruitment of Gab1 to Met or epidermal growth factor (EGF) receptors requires a receptor-binding site for the Grb2 adapter protein and a proline-rich domain in Gab1, defined as the Met-binding domain.	Proline	138-145	epidermal growth factor	Homo sapiens	30-53
10913131-3	2000	Recruitment of Gab1 to Met or epidermal growth factor (EGF) receptors requires a receptor-binding site for the Grb2 adapter protein and a proline-rich domain in Gab1, defined as the Met-binding domain.	Proline	138-145	epidermal growth factor	Homo sapiens	55-58
10913131-3	2000	Recruitment of Gab1 to Met or epidermal growth factor (EGF) receptors requires a receptor-binding site for the Grb2 adapter protein and a proline-rich domain in Gab1, defined as the Met-binding domain.	Proline	138-145	GRB2 associated binding protein 1	Homo sapiens	161-165
10913131-5	2000	One corresponds to a canonical Grb2-binding motif, whereas the second, located within the Gab1 Met-binding domain, requires the proline and arginine residues of an atypical PXXXR motif.	Proline	128-135	GRB2 associated binding protein 1	Homo sapiens	90-94
10996832-6	2000	This mutation, CTC:wild-type to CCC:mutant, is similar to that of another African American family where the resulting leucine to proline substitution in the 5(th) leucine-rich repeat of GP Ib alpha is responsible for the observed BSs phenotype.	Proline	129-136	glycoprotein Ib platelet subunit alpha	Homo sapiens	186-197
11080615-1	2000	c-Abl preferentially phosphorylates peptide substrates that contain proline at the P+3 site (relative to the phosphorylated tyrosine).	Proline	68-75	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-5
10978770-8	2000	Sequence analysis of these four DAAO mutants indicated the occurrence of mutations at Val-167, Pro-291, Pro-309, and Ala-343 residues.	Proline	95-98	D-amino acid oxidase	Sus scrofa	32-36
11080615-3	2000	In this study, we examine the phosphorylation of Crk, a protein substrate of Abl that is phosphorylated in the sequence Tyr221-Ala-Gln-Pro.	Proline	135-138	CRK proto-oncogene, adaptor protein	Homo sapiens	49-52
11080615-3	2000	In this study, we examine the phosphorylation of Crk, a protein substrate of Abl that is phosphorylated in the sequence Tyr221-Ala-Gln-Pro.	Proline	135-138	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	77-80
10978770-8	2000	Sequence analysis of these four DAAO mutants indicated the occurrence of mutations at Val-167, Pro-291, Pro-309, and Ala-343 residues.	Proline	104-107	D-amino acid oxidase	Sus scrofa	32-36
11061286-9	2000	The pattern of sequence conservation indicates also that strong selection pressure was imposed on a motif VYYW at the C-end of the transmembrane domain and on a CD3epsilon-specific proline-rich motif RXPPVP juxtaposed to the N-terminus of the ITAM.	Proline	181-188	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	161-171
11070166-1	2000	The structure of the A6 alphabetaTCR/HTLV-1 Tax-peptide/MHC I complex with proline 6 of Tax substituted with alanine (P6A), an antagonist, is nearly identical to the structure with wild-type Tax agonist.	Proline	75-82	major histocompatibility complex, class I, C	Homo sapiens	56-59
11053466-1	2000	Budding yeast strains that produced the Arabidopsis thaliana protein CEF or its amino-terminal proline-rich domain were more tolerant to hydroperoxides.	Proline	95-102	hypothetical protein	Arabidopsis thaliana	69-72
11090625-2	2000	The pSer/Thr-Pro moiety in peptides exists in the two completely distinct cis and trans conformations whose conversion is catalyzed specifically by the essential prolyl isomerase Pin1.	Proline	13-16	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	179-183
11069665-2	2000	Introduction of amino acid changes Val-219Asp and Ala-220Pro, which enter a proline kink at the interdomain region (B linker) between the A (signal reception) module and the central portion of XylR, originated a protein with unforeseen properties.	Proline	76-83	xylose operon regulatory protein	Pseudomonas putida	193-197
11072671-2	2000	In invasive cervical cancer, the arginine form of the p53 gene is estimated to be more susceptible to degradation mediated by tumour-associated human papilloma viruses (HPV) than the proline form.	Proline	183-190	tumor protein p53	Homo sapiens	54-57
11372379-9	2000	CM from LDL-treated HK-2 also showed the stimulated proline incorporation and secretion of fibronectin or laminin.	Proline	52-59	hexokinase 2	Homo sapiens	20-24
11148267-0	2000	Oscillation and regulation of proline content by P5CS and ProDH gene expressions in the light/dark cycles in Arabidopsis thaliana L. The fluctuation of proline content, and protein and mRNA levels of delta1-pyrroline-5-carboxylate synthetase (P5CS) and proline dehydrogenase (ProDH), both of which are involved in proline biosynthesis and degradation, in the shoots of Arabidopsis grown in light/dark cycles were demonstrated under salt-stressed and unstressed conditions.	Proline	30-37	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	58-63
11127705-0	2000	Distributions of p53 codon 72 polymorphism in bladder cancer--proline form is prominent in invasive tumor.	Proline	62-69	tumor protein p53	Homo sapiens	17-20
11006099-2	2000	We investigated some features of these two models for the GluR1 subunit by inserting epitope tags between residues Lys(502)-Pro(503), Ala(632)-Glu(633), Lys(712)-Pro(713), or after the C-terminal residue Leu(889).	Proline	124-127	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	58-63
10862775-0	2000	Unraveling the amino acid sequence crucial for heparin binding to collagen V. We have previously shown that a recombinant 12-kDa fragment of the collagen alpha1(V) chain (Ile(824)-Pro(950)), referred to as HepV, binds to heparin and heparan sulfate (Delacoux, F., Fichard, A., Geourjon, C., Garrone, R., and Ruggiero, F. (1998) J. Biol.	Proline	180-183	collagen type V alpha 1 chain	Homo sapiens	154-163
10900204-1	2000	Possible role of a proline-rich motif of KIAA0380 in localization.	Proline	19-26	Rho guanine nucleotide exchange factor (GEF) 11	Mus musculus	41-49
10900204-6	2000	Molecular dissection analyses revealed that a proline-rich motif C-terminally adjacent to DH/PH domain is essential for plasma membrane localization of KIAA0380 and cortical actin reorganization followed by cell rounding.	Proline	46-53	Rho guanine nucleotide exchange factor (GEF) 11	Mus musculus	152-160
10900204-7	2000	In contrast, the DH/PH domain of KIAA0380 is localized in the cytoplasm, where it activates Rho/Rho kinase and induces stress fiber formation, consistent with results using p115 Rho guanine nucleotide exchange factor, which has a similar structure to KIAA0380 but lacks a proline-rich motif.	Proline	272-279	Rho guanine nucleotide exchange factor (GEF) 11	Mus musculus	33-41
10900204-8	2000	These results suggest that upon stimulation, KIAA0380 translocates to the plasma membrane via the proline-rich motif and there activates Rho/Rho kinase signaling.	Proline	98-105	Rho guanine nucleotide exchange factor (GEF) 11	Mus musculus	45-53
10900204-8	2000	These results suggest that upon stimulation, KIAA0380 translocates to the plasma membrane via the proline-rich motif and there activates Rho/Rho kinase signaling.	Proline	98-105	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	141-151
11008209-10	2000	This result remained similar (OR 2.2, 95% CI 1.0-4.8 for p53 Pro/Pro vs. Arg/Arg), even after further adjustment for NAT2 and GSTP1 polymorphisms.	Proline	61-64	tumor protein p53	Homo sapiens	57-60
11008209-10	2000	This result remained similar (OR 2.2, 95% CI 1.0-4.8 for p53 Pro/Pro vs. Arg/Arg), even after further adjustment for NAT2 and GSTP1 polymorphisms.	Proline	65-68	tumor protein p53	Homo sapiens	57-60
10867010-5	2000	In addition, the dimeric and monomeric forms of rBoAChE were quantitatively converted to tetramers by complexation with a synthetic peptide representing the human ColQ-derived proline-rich attachment domain.	Proline	176-183	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	163-167
10986122-5	2000	Previous work has identified an intramolecular regulatory association between the proline-rich region and the adjacent SH3 domain of Itk.	Proline	82-89	IL2 inducible T cell kinase	Homo sapiens	133-136
11006099-2	2000	We investigated some features of these two models for the GluR1 subunit by inserting epitope tags between residues Lys(502)-Pro(503), Ala(632)-Glu(633), Lys(712)-Pro(713), or after the C-terminal residue Leu(889).	Proline	162-165	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	58-63
11006099-4	2000	The epitope tag inserted between residues Lys(712)-Pro(713) is extracellular and after Leu(889) intracellular.	Proline	51-54	long intergenic non-protein coding RNA 1194	Homo sapiens	12-15
10862766-6	2000	In this study, we substituted a proposed stabilizing leucine residue in the zipper domain with a helix-disrupting proline to abrogate zipper-mediated SPRK oligomerization.	Proline	114-121	mitogen-activated protein kinase kinase kinase 11	Mus musculus	150-154
10988244-7	2000	However, inhibition of collagen synthesis using cis-4-hydroxyproline resulted in a decrease in EGF-related HFVM proliferation and DNA and protein synthesis, which was reversed by exposure to L-proline but not by growth on type I collagen.	Proline	191-200	epidermal growth factor	Homo sapiens	95-98
11017794-4	2000	In cells stably transfected with Wa NSP4, we found that proline(138) was changed to either serine or threonine.	Proline	56-63	protease, serine 57	Mus musculus	36-40
10823838-6	2000	This observation led to the identification of amino acid residues, Leu(397), Ala(406), Asp(410), and Pro(415), in this region of gelatinase B that are important for its efficient catalysis as determined by substituting these amino acids with the corresponding residues from fibroblast collagenase.	Proline	101-104	matrix metallopeptidase 1	Homo sapiens	274-296
11032405-3	2000	Here we report that intercellular channels containing mutations of G12 in Cx32 to residues that are likely to interfere with flexibility of this locus (G12S, G12Y, and G12V) do not express junctional currents, whereas a connexin containing a proline residue at G12 (Cx32G12P), which is expected to maintain a structure similar to that of the G12 locus, forms nearly wild-type channels.	Proline	242-249	gap junction protein beta 1	Homo sapiens	74-78
10965879-9	2000	PKB/Akt immunoprecipitated from IGFBP-3-pretreated cells was no longer recognized by an antibody specific for phosphorylated threonine followed by proline.	Proline	147-154	AKT serine/threonine kinase 1	Bos taurus	0-3
10978530-3	2000	It possesses a Src homology 3 (SH3) motif, proline-rich region, serine-rich region and no catalytic domain, suggesting that it seems to be a signaling protein most similar to e3B1, an eps8 SH3 binding protein.	Proline	43-50	abl interactor 1	Homo sapiens	175-179
10965879-9	2000	PKB/Akt immunoprecipitated from IGFBP-3-pretreated cells was no longer recognized by an antibody specific for phosphorylated threonine followed by proline.	Proline	147-154	AKT serine/threonine kinase 1	Bos taurus	4-7
10965879-9	2000	PKB/Akt immunoprecipitated from IGFBP-3-pretreated cells was no longer recognized by an antibody specific for phosphorylated threonine followed by proline.	Proline	147-154	insulin like growth factor binding protein 3	Bos taurus	32-39
10859301-5	2000	In the present study, we have investigated the influence of Pro(275), Leu(278), and Glu(280) on the proteasomal digestion of MAGE-3(271-285) substituted at these positions.	Proline	60-63	MAGE family member A3	Homo sapiens	125-131
10978248-5	2000	Deletion of the proline-rich domain of VASP abolishes its ability to bind profilin but does not affect ruffling or stress fiber formation.	Proline	16-23	vasodilator stimulated phosphoprotein	Bos taurus	39-43
11240705-1	2000	Recent analysis of the codon-72 polymorphism of the p53 gene, the allele encoding proline or arginine, suggested that the homozygous Arg/Arg genotype is a significant risk factor for cervical cancer associated with human papillomavirus (HPV).	Proline	82-89	tumor protein p53	Homo sapiens	52-55
11008076-7	2000	We found an association between the TGF-beta 1 genotype encoding proline at codon 10 and renal dysfunction.	Proline	65-72	transforming growth factor beta 1	Homo sapiens	36-46
10972829-6	2000	Structure predictions of SpvB indicated that it is composed of a C-terminal ADP-ribosyltransferase domain fused via a poly proline stretch to a N-domain resembling the N-domain of the secretory toxin TcaC from nematode-infecting enterobacteria.	Proline	123-130	virulence protein	Salmonella enterica	25-29
10938133-5	2000	RFX5 was found to interact with CIITA, and this interaction was dependent on a proline-rich domain within RFX5.	Proline	79-86	regulatory factor X5	Homo sapiens	0-4
10938133-5	2000	RFX5 was found to interact with CIITA, and this interaction was dependent on a proline-rich domain within RFX5.	Proline	79-86	class II major histocompatibility complex transactivator	Homo sapiens	32-37
10938133-5	2000	RFX5 was found to interact with CIITA, and this interaction was dependent on a proline-rich domain within RFX5.	Proline	79-86	regulatory factor X5	Homo sapiens	106-110
10973247-8	2000	The inner ear Ush1c transcripts predicted several harmonin isoforms, some containing an additional coiled-coil domain and a proline- and serine-rich region.	Proline	124-131	USH1 protein network component harmonin	Mus musculus	14-19
10972890-4	2000	The AtEPR1 open reading frame consists of 40 proline-rich repeats and is expressed in both wild-type and mutant lines.	Proline	45-52	extensin proline-rich 1	Arabidopsis thaliana	4-10
11117266-9	2000	The analysis indicates that the precursors p-coumaryl and coniferyl alcohols are preferred by ATP A2, while the oxidation of sinapyl alcohol will be sterically hindered in ATP A2 as well as in all other plant peroxidases due to an overlap with the conserved Pro-139.	Proline	258-261	peroxidase 2	Arabidopsis thaliana	172-178
10931874-4	2000	Palladin has a proline-rich region in the NH(2)-terminal half of the molecule and three tandem Ig C2 domains in the COOH-terminal half.	Proline	15-22	palladin, cytoskeletal associated protein	Mus musculus	0-8
11877024-5	2000	The mutation in the patients" ALAS2 gene was exon 5 A523G, causing threonine to alanine; and exon 3 T372C, leucine to proline.	Proline	118-125	5'-aminolevulinate synthase 2	Homo sapiens	30-35
10831586-5	2000	The phosphorylation of p27(Kip1) was markedly reduced when the positions of Ser(10) and Pro(11) were reversed, suggesting that a proline-directed kinase is responsible for the phosphorylation of Ser(10).	Proline	88-91	zinc ribbon domain containing 2	Homo sapiens	23-26
10831586-5	2000	The phosphorylation of p27(Kip1) was markedly reduced when the positions of Ser(10) and Pro(11) were reversed, suggesting that a proline-directed kinase is responsible for the phosphorylation of Ser(10).	Proline	88-91	cyclin dependent kinase inhibitor 1B	Homo sapiens	27-31
10931524-6	2000	Truncations of the GAL4-Gtx fusion identified a portable repressor domain within a relatively proline/alanine-rich region N-terminal to the Gtx homeodomain.	Proline	94-101	galectin 4	Homo sapiens	19-23
10931524-6	2000	Truncations of the GAL4-Gtx fusion identified a portable repressor domain within a relatively proline/alanine-rich region N-terminal to the Gtx homeodomain.	Proline	94-101	NK6 homeobox 2	Homo sapiens	24-27
10931524-6	2000	Truncations of the GAL4-Gtx fusion identified a portable repressor domain within a relatively proline/alanine-rich region N-terminal to the Gtx homeodomain.	Proline	94-101	NK6 homeobox 2	Homo sapiens	140-143
10924141-7	2000	Substitution of the aligned lysine and proline residues does, however, reduce structural stability, consistent with a temperature sensitive phenotype that results from substitution of the cognate proline residue in Cbf5p, a yeast homologue of TruB [Zerbarjadian, Y., King, T., Fournier, M. J., Clarke, L., and Carbon, J.	Proline	39-46	pseudouridine synthase CBF5	Saccharomyces cerevisiae S288C	215-220
10924141-7	2000	Substitution of the aligned lysine and proline residues does, however, reduce structural stability, consistent with a temperature sensitive phenotype that results from substitution of the cognate proline residue in Cbf5p, a yeast homologue of TruB [Zerbarjadian, Y., King, T., Fournier, M. J., Clarke, L., and Carbon, J.	Proline	196-203	pseudouridine synthase CBF5	Saccharomyces cerevisiae S288C	215-220
10992167-1	2000	The sluggish-A (slgA) gene of Drosophila melanogaster has been shown to encode for the enzyme proline oxidase, a mitochondrial enzyme which catalyzes the first step in the conversion of L-proline to L-glutamate.	Proline	186-195	sluggish A	Drosophila melanogaster	4-14
10992167-1	2000	The sluggish-A (slgA) gene of Drosophila melanogaster has been shown to encode for the enzyme proline oxidase, a mitochondrial enzyme which catalyzes the first step in the conversion of L-proline to L-glutamate.	Proline	186-195	sluggish A	Drosophila melanogaster	16-20
10992167-8	2000	Proline is elevated in muscle cells of slgA mutants, indicating that the slgA gene regulates tissue proline levels.	Proline	0-7	sluggish A	Drosophila melanogaster	39-43
10992167-8	2000	Proline is elevated in muscle cells of slgA mutants, indicating that the slgA gene regulates tissue proline levels.	Proline	0-7	sluggish A	Drosophila melanogaster	73-77
10992167-8	2000	Proline is elevated in muscle cells of slgA mutants, indicating that the slgA gene regulates tissue proline levels.	Proline	100-107	sluggish A	Drosophila melanogaster	39-43
10992167-8	2000	Proline is elevated in muscle cells of slgA mutants, indicating that the slgA gene regulates tissue proline levels.	Proline	100-107	sluggish A	Drosophila melanogaster	73-77
10966780-1	2000	To explore the ways that proline residues may influence the conformational options of a polypeptide backbone, we have characterized Pro--&gt;Ala mutants of cellular retinoic acid-binding protein I (CRABP I).	Proline	25-32	cellular retinoic acid binding protein 1	Homo sapiens	156-196
10966780-1	2000	To explore the ways that proline residues may influence the conformational options of a polypeptide backbone, we have characterized Pro--&gt;Ala mutants of cellular retinoic acid-binding protein I (CRABP I).	Proline	25-32	cellular retinoic acid binding protein 1	Homo sapiens	198-205
10825173-3	2000	The tropoelastin-binding site was localized to a region beginning at the glycine-rich and proline-rich regions of fibrillin-2 and fibrillin-1, respectively, and continuing through the second 8-cysteine domain.	Proline	90-97	elastin	Homo sapiens	4-16
10825173-3	2000	The tropoelastin-binding site was localized to a region beginning at the glycine-rich and proline-rich regions of fibrillin-2 and fibrillin-1, respectively, and continuing through the second 8-cysteine domain.	Proline	90-97	fibrillin 2	Homo sapiens	114-125
10825173-3	2000	The tropoelastin-binding site was localized to a region beginning at the glycine-rich and proline-rich regions of fibrillin-2 and fibrillin-1, respectively, and continuing through the second 8-cysteine domain.	Proline	90-97	fibrillin 1	Homo sapiens	130-141
10942429-1	2000	Pfeiffer syndrome is a classic form of craniosynostosis that is caused by a proline--&gt;arginine substitution at amino acid 252 (Pro252Arg) in fibroblast growth factor receptor 1 (FGFR1).	Proline	76-83	fibroblast growth factor receptor 1	Mus musculus	144-179
10942429-1	2000	Pfeiffer syndrome is a classic form of craniosynostosis that is caused by a proline--&gt;arginine substitution at amino acid 252 (Pro252Arg) in fibroblast growth factor receptor 1 (FGFR1).	Proline	76-83	fibroblast growth factor receptor 1	Mus musculus	181-186
10926541-3	2000	The familial mutation substitutes a proline for a highly conserved alanine at position 114 in the ANT1 protein.	Proline	36-43	solute carrier family 25 member 4	Homo sapiens	98-102
10894734-7	2000	When this novel MPR1 or MPR2 gene (sigma 1278b gene for L-proline analogue resistance) was introduced into the other S. cerevisiae strains, all of the recombinants were resistant to L-azetidine-2-carboxylic acid, indicating that both MPR1 and MPR2 are expressed and have a global function in S. cerevisiae.	Proline	56-65	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	16-20
10940929-3	2000	We observed association between the PLCgamma1-SH3 domain and the human Ras guanine nucleotide exchange factor son-of-sevenless-2 (hSos2) through a proline-rich domain interaction.	Proline	147-154	phospholipase C gamma 1	Homo sapiens	36-45
10940929-3	2000	We observed association between the PLCgamma1-SH3 domain and the human Ras guanine nucleotide exchange factor son-of-sevenless-2 (hSos2) through a proline-rich domain interaction.	Proline	147-154	SOS Ras/Rho guanine nucleotide exchange factor 2	Homo sapiens	130-135
10896908-7	2000	IL-1alpha and IL-8 also significantly increased L-proline absorption due to an increase in absorptive flux.	Proline	48-57	interleukin-1 alpha	Oryctolagus cuniculus	0-9
10896908-7	2000	IL-1alpha and IL-8 also significantly increased L-proline absorption due to an increase in absorptive flux.	Proline	48-57	interleukin-8	Oryctolagus cuniculus	14-18
10913293-8	2000	The reductive half-reaction with L-proline at 4 degrees C exhibited saturation kinetics (k(lim) = 6.0 min(-)(1), K(d) = 260 mM) and other features consistent with a mechanism in which a practically irreversible reduction step (E(ox).	Proline	33-42	PDZ and LIM domain 5	Homo sapiens	91-94
11042028-5	2000	The deletion of proline at alpha37(C2) is predicted to result in severe instability of the variant hemoglobin, which on interaction with a synthesis-deficient alpha-thalassemia mutation causes a relatively severe dyserythropoietic anemia, representing an alternative phenotype associated with highly unstable alpha-chain variants.	Proline	16-23	Fc gamma receptor and transporter	Homo sapiens	309-320
11042028-7	2000	Two variants involve the alpha2-globin gene: Hb Agrinio (alpha29(B10)Leu>Pro) and Hb Adana (alpha59(E8)Gly>Asp), and two the alpha1-gene: Hb Aghia Sophia (alpha62(E11)Val>0) and (Hb Heraklion a37(C2)Pro>0).	Proline	73-76	hemoglobin subunit alpha 2	Homo sapiens	25-38
11035260-1	2000	The thioredoxins are ubiquitous proteins containing a conserved -Trp-Cys-Gly-Pro-Cys-Lys- redox catalytic site.	Proline	77-80	thioredoxin	Homo sapiens	4-16
10894734-7	2000	When this novel MPR1 or MPR2 gene (sigma 1278b gene for L-proline analogue resistance) was introduced into the other S. cerevisiae strains, all of the recombinants were resistant to L-azetidine-2-carboxylic acid, indicating that both MPR1 and MPR2 are expressed and have a global function in S. cerevisiae.	Proline	56-65	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	234-238
10903746-1	2000	The hemopoietic-specific Gads (Grb2-related adaptor downstream of Shc) adaptor protein possesses amino- and carboxyl-terminal Src homology 3 (SH3) domains flanking a central SH2 domain and a unique region rich in glutamine and proline residues.	Proline	227-234	GRB2-related adaptor protein 2	Mus musculus	25-29
10903746-5	2000	HPK1 kinase activity is up-regulated in response to activation of the TCR and requires the presence of its proline-rich motifs.	Proline	107-114	mitogen-activated protein kinase kinase kinase kinase 1	Mus musculus	0-4
10903746-5	2000	HPK1 kinase activity is up-regulated in response to activation of the TCR and requires the presence of its proline-rich motifs.	Proline	107-114	T cell receptor alpha variable 6-3	Mus musculus	70-73
10903746-1	2000	The hemopoietic-specific Gads (Grb2-related adaptor downstream of Shc) adaptor protein possesses amino- and carboxyl-terminal Src homology 3 (SH3) domains flanking a central SH2 domain and a unique region rich in glutamine and proline residues.	Proline	227-234	GRB2-related adaptor protein 2	Mus musculus	31-69
10903746-6	2000	Mapping experiments have revealed that the carboxyl-terminal SH3 domain of Gads and the fourth proline-rich region of HPK1 are essential for their interaction.	Proline	95-102	GRB2-related adaptor protein 2	Mus musculus	75-79
10913193-3	2000	We found that Sik interacts with Sam68 through its SH3 and SH2 domains and that the proline-rich P3 region of Sam68 is required for Sik and BRK SH3 binding.	Proline	84-91	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	110-115
10903746-6	2000	Mapping experiments have revealed that the carboxyl-terminal SH3 domain of Gads and the fourth proline-rich region of HPK1 are essential for their interaction.	Proline	95-102	mitogen-activated protein kinase kinase kinase kinase 1	Mus musculus	118-122
10903746-7	2000	Deletion of the fourth proline-rich region of HPK1 or expression of a Gads SH2 mutant in T cells inhibits TCR-induced HPK1 tyrosine phosphorylation.	Proline	23-30	mitogen-activated protein kinase kinase kinase kinase 1	Mus musculus	46-50
10903746-7	2000	Deletion of the fourth proline-rich region of HPK1 or expression of a Gads SH2 mutant in T cells inhibits TCR-induced HPK1 tyrosine phosphorylation.	Proline	23-30	T cell receptor alpha variable 6-3	Mus musculus	106-109
10903746-7	2000	Deletion of the fourth proline-rich region of HPK1 or expression of a Gads SH2 mutant in T cells inhibits TCR-induced HPK1 tyrosine phosphorylation.	Proline	23-30	mitogen-activated protein kinase kinase kinase kinase 1	Mus musculus	118-122
10903747-8	2000	Further characterization uncovered a point mutation in the 303.1.5.LM mb1 gene that would change a proline for a leucine in the extracellular domain of Ig-alpha.	Proline	99-106	CD79a molecule	Homo sapiens	70-73
10903747-8	2000	Further characterization uncovered a point mutation in the 303.1.5.LM mb1 gene that would change a proline for a leucine in the extracellular domain of Ig-alpha.	Proline	99-106	CD79a molecule	Homo sapiens	152-160
10932245-3	2000	The C-terminal region of dystrophin binds the cytoplasmic tail of beta-dystroglycan, in part through the interaction of its WW domain with a proline-rich motif in the tail of beta-dystroglycan.	Proline	141-148	dystrophin	Homo sapiens	25-35
10913193-3	2000	We found that Sik interacts with Sam68 through its SH3 and SH2 domains and that the proline-rich P3 region of Sam68 is required for Sik and BRK SH3 binding.	Proline	84-91	salt inducible kinase 1	Homo sapiens	132-135
10932245-4	2000	Here we report the crystal structure of this portion of dystrophin in complex with the proline-rich binding site in beta-dystroglycan.	Proline	87-94	dystrophin	Homo sapiens	56-66
10932246-2	2000	To address the energetic and structural basis for WW domain recognition of phosphoserine (P.Ser)/phosphothreonine (P. Thr)- proline containing proteins, we report the energetic and structural analysis of a Pin1-phosphopeptide complex.	Proline	124-131	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	206-210
10932246-3	2000	The X-ray crystal structure of Pin1 bound to a doubly phosphorylated peptide (Tyr-P.Ser-Pro-Thr-P.Ser-Pro-Ser) representing a heptad repeat of the RNA polymerase II large subunit"s C-terminal domain (CTD), reveals the residues involved in the recognition of a single P.Ser side chain, the rings of two prolines, and the backbone of the CTD peptide.	Proline	88-91	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	31-35
10913193-3	2000	We found that Sik interacts with Sam68 through its SH3 and SH2 domains and that the proline-rich P3 region of Sam68 is required for Sik and BRK SH3 binding.	Proline	84-91	protein tyrosine kinase 6	Homo sapiens	140-143
10932246-3	2000	The X-ray crystal structure of Pin1 bound to a doubly phosphorylated peptide (Tyr-P.Ser-Pro-Thr-P.Ser-Pro-Ser) representing a heptad repeat of the RNA polymerase II large subunit"s C-terminal domain (CTD), reveals the residues involved in the recognition of a single P.Ser side chain, the rings of two prolines, and the backbone of the CTD peptide.	Proline	302-310	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	31-35
10922466-3	2000	The proline-directed p42 mitogen-activated protein kinase (ERK2) was used to phosphorylate the serine side chain in Pro-Arg-Ser-Pro-Phe-4-nitroanilide under conditions where different amounts of cis prolyl isomer of the substrate were present.	Proline	4-11	cyclin dependent kinase 20	Homo sapiens	21-24
10807905-4	2000	Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123).	Proline	109-112	S100 calcium binding protein B	Homo sapiens	15-18
10807905-4	2000	Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123).	Proline	109-112	acyl-CoA thioesterase 8	Homo sapiens	23-26
10807905-4	2000	Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123).	Proline	109-112	S100 calcium binding protein B	Homo sapiens	63-66
10922466-3	2000	The proline-directed p42 mitogen-activated protein kinase (ERK2) was used to phosphorylate the serine side chain in Pro-Arg-Ser-Pro-Phe-4-nitroanilide under conditions where different amounts of cis prolyl isomer of the substrate were present.	Proline	4-11	mitogen-activated protein kinase 1	Homo sapiens	59-63
10913276-5	2000	The carboxyl-terminal proline-rich domain of SOS1 is involved in the interaction with the PLC-gamma1 SH3 domain.	Proline	22-29	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	45-49
10913276-5	2000	The carboxyl-terminal proline-rich domain of SOS1 is involved in the interaction with the PLC-gamma1 SH3 domain.	Proline	22-29	phospholipase C gamma 1	Homo sapiens	90-100
10903901-1	2000	The beta-dystroglycan/Grb2 interaction was investigated and a proline-rich region within beta-dystroglycan that binds Grb2-src homology 3 domains identified.	Proline	62-69	dystroglycan 1	Homo sapiens	9-21
10913839-0	2000	Role of alpha-helical conformation of histatin-5 in candidacidal activity examined by proline variants.	Proline	86-93	histatin 3	Homo sapiens	38-48
10913839-7	2000	These results suggested that the alpha-helical content of Hsn-5 proline variants does not correlate with the candidacidal activity.	Proline	64-71	histatin 3	Homo sapiens	58-63
10801818-1	2000	Zyxin contains a proline-rich N-terminal domain that is similar to the C-terminal domain in the ActA protein of the bacteria, Listeria monocytogenes.	Proline	17-24	zyxin	Homo sapiens	0-5
10801818-2	2000	We screened the entire amino acid sequence of human zyxin for Mena-interacting peptides and found that, as with ActA, proline-rich sequences were the sole zyxin sequences capable of binding to Ena/vasodilator-stimulated phosphoprotein (VASP) family members in vitro.	Proline	118-125	zyxin	Homo sapiens	52-57
10801818-2	2000	We screened the entire amino acid sequence of human zyxin for Mena-interacting peptides and found that, as with ActA, proline-rich sequences were the sole zyxin sequences capable of binding to Ena/vasodilator-stimulated phosphoprotein (VASP) family members in vitro.	Proline	118-125	ENAH actin regulator	Homo sapiens	62-66
10801818-2	2000	We screened the entire amino acid sequence of human zyxin for Mena-interacting peptides and found that, as with ActA, proline-rich sequences were the sole zyxin sequences capable of binding to Ena/vasodilator-stimulated phosphoprotein (VASP) family members in vitro.	Proline	118-125	vasodilator stimulated phosphoprotein	Homo sapiens	193-234
10801818-3	2000	From this information, we tested zyxin mutants in which the proline-rich sequences were altered.	Proline	60-67	zyxin	Homo sapiens	33-38
10801818-6	2000	Microinjection into cells of peptides corresponding to the first proline-rich sequence of zyxin caused the loss of Mena/VASP from focal contacts.	Proline	65-72	zyxin	Homo sapiens	90-95
10801818-6	2000	Microinjection into cells of peptides corresponding to the first proline-rich sequence of zyxin caused the loss of Mena/VASP from focal contacts.	Proline	65-72	ENAH actin regulator	Homo sapiens	115-119
10801818-6	2000	Microinjection into cells of peptides corresponding to the first proline-rich sequence of zyxin caused the loss of Mena/VASP from focal contacts.	Proline	65-72	vasodilator stimulated phosphoprotein	Homo sapiens	120-124
10801818-8	2000	We conclude that zyxin and proteins that harbor similar proline-rich repeats contribute to the positioning of Mena/VASP proteins.	Proline	56-63	zyxin	Homo sapiens	17-22
10951563-9	2000	While our data implied that Gros1 is a novel growth suppressor gene on human chromosome 1, an independent study has recently characterized its rat-homolog as a leucine proline-enriched novel basement membrane-associated proteoglycan leprecan.	Proline	168-175	prolyl 3-hydroxylase 1	Homo sapiens	28-33
10951563-9	2000	While our data implied that Gros1 is a novel growth suppressor gene on human chromosome 1, an independent study has recently characterized its rat-homolog as a leucine proline-enriched novel basement membrane-associated proteoglycan leprecan.	Proline	168-175	prolyl 3-hydroxylase 1	Homo sapiens	233-241
10903430-5	2000	The impact of dynamin II on vesicle formation is demonstrated by incubating the Golgi with the proline-rich domain of dynamin II which concomitantly displaces dynamin II and inhibits vesicle formation.	Proline	95-102	dynamin 2	Homo sapiens	14-24
10903430-5	2000	The impact of dynamin II on vesicle formation is demonstrated by incubating the Golgi with the proline-rich domain of dynamin II which concomitantly displaces dynamin II and inhibits vesicle formation.	Proline	95-102	dynamin 2	Homo sapiens	118-128
10903430-5	2000	The impact of dynamin II on vesicle formation is demonstrated by incubating the Golgi with the proline-rich domain of dynamin II which concomitantly displaces dynamin II and inhibits vesicle formation.	Proline	95-102	dynamin 2	Homo sapiens	118-128
10903901-1	2000	The beta-dystroglycan/Grb2 interaction was investigated and a proline-rich region within beta-dystroglycan that binds Grb2-src homology 3 domains identified.	Proline	62-69	dystroglycan 1	Homo sapiens	94-106
10903901-1	2000	The beta-dystroglycan/Grb2 interaction was investigated and a proline-rich region within beta-dystroglycan that binds Grb2-src homology 3 domains identified.	Proline	62-69	growth factor receptor bound protein 2	Homo sapiens	118-122
10801818-8	2000	We conclude that zyxin and proteins that harbor similar proline-rich repeats contribute to the positioning of Mena/VASP proteins.	Proline	56-63	ENAH actin regulator	Homo sapiens	110-114
10887137-4	2000	When fused to the intracellular domain of FGFR1, the ZNF198 proline-rich region is sufficient to cause oligomerization, FGFR1 tyrosine kinase activation, and transformation of Ba/F3 cells to IL-3 independent growth.	Proline	60-67	fibroblast growth factor receptor 1	Mus musculus	42-47
10801818-8	2000	We conclude that zyxin and proteins that harbor similar proline-rich repeats contribute to the positioning of Mena/VASP proteins.	Proline	56-63	vasodilator stimulated phosphoprotein	Homo sapiens	115-119
10887137-4	2000	When fused to the intracellular domain of FGFR1, the ZNF198 proline-rich region is sufficient to cause oligomerization, FGFR1 tyrosine kinase activation, and transformation of Ba/F3 cells to IL-3 independent growth.	Proline	60-67	zinc finger, MYM-type 2	Mus musculus	53-59
10887137-0	2000	ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain.	Proline	54-61	zinc finger, MYM-type 2	Mus musculus	0-6
10887137-0	2000	ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain.	Proline	54-61	fibroblast growth factor receptor 1	Mus musculus	7-12
10887137-4	2000	When fused to the intracellular domain of FGFR1, the ZNF198 proline-rich region is sufficient to cause oligomerization, FGFR1 tyrosine kinase activation, and transformation of Ba/F3 cells to IL-3 independent growth.	Proline	60-67	fibroblast growth factor receptor 1	Mus musculus	120-125
10887137-0	2000	ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain.	Proline	54-61	zinc finger, MYM-type 2	Mus musculus	67-73
10887137-4	2000	When fused to the intracellular domain of FGFR1, the ZNF198 proline-rich region is sufficient to cause oligomerization, FGFR1 tyrosine kinase activation, and transformation of Ba/F3 cells to IL-3 independent growth.	Proline	60-67	interleukin 3	Mus musculus	191-195
10887137-2	2000	ZNF198-FGFR1 fusion transcripts encode 4 to 10 zinc fingers, a proline-rich region, and the intracellular portion of the FGFR1 (fibroblast growth factor receptor 1) receptor tyrosine kinase.	Proline	63-70	zinc finger, MYM-type 2	Mus musculus	0-6
10887137-2	2000	ZNF198-FGFR1 fusion transcripts encode 4 to 10 zinc fingers, a proline-rich region, and the intracellular portion of the FGFR1 (fibroblast growth factor receptor 1) receptor tyrosine kinase.	Proline	63-70	fibroblast growth factor receptor 1	Mus musculus	7-12
10887201-3	2000	Here we show that the N-terminal region of NIK contains a negative-regulatory domain (NRD), which is composed of a basic motif and a proline-rich repeat motif.	Proline	133-140	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	43-46
10887137-3	2000	We demonstrate that the ZNF198 proline-rich region constitutes a novel self-association domain.	Proline	31-38	zinc finger, MYM-type 2	Mus musculus	24-30
10961508-0	2000	A Pro --&gt; Ala substitution in melittin affects self-association, membrane binding and pore-formation kinetics due to changes in structural and electrostatic properties Melittin, the main component of bee venom of Apis mellifera, contains a proline at position 14, which is highly conserved in related peptides of various bee venoms.	Proline	243-250	melittin	Apis mellifera	33-41
10961508-1	2000	To investigate the structural and functional role of Pro14 a melittin analogue was studied where proline is substituted by an alanine residue (P14A).	Proline	97-104	melittin	Apis mellifera	61-69
10961508-7	2000	The different features of P14A in aggregation, binding and efflux compared to melittin are mainly ascribable directly to structural changes caused by the proline --&gt; alanine substitution.	Proline	154-161	melittin	Apis mellifera	78-86
10961508-9	2000	It is suggested that the presence of proline in melittin is not only of structural importance but also influences indirectly the electrostatic properties of the native peptide.	Proline	37-44	melittin	Apis mellifera	48-56
10893263-6	2000	A truncated dyn2 lacking the COOH-terminal proline/arginine-rich domain (PRD), which interacts with many SH3 domain-containing partners implicated in both endocytosis and signal transduction, triggers apoptosis even more potently than the wild-type.	Proline	43-50	dynamin 2	Homo sapiens	12-16
10891341-4	2000	Rabbit CD38 was also 28% homologous to Aplysia ADP-ribosyl cyclase and leukocyte CD157 (another ADP-ribosyl cyclase); the three cyclases shared 10 cysteine and 2 adjacent proline residues.	Proline	171-178	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	Oryctolagus cuniculus	7-11
10781604-2	2000	The amino-terminal half of Rsp5 consists of four domains: a C2 domain, which binds membrane phospholipids; and three WW domains, which are protein interaction modules that bind proline-rich ligands.	Proline	177-184	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	27-31
10874277-4	2000	DNA sequencing of the KVLQT1 gene of the proband revealed a T-->C transversion at the second position of codon 122, which predicted a substitution of proline for leucine (L122P).	Proline	150-157	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	22-28
10869177-0	2000	Circular dichroic investigation of the native and non-native conformational states of the growth factor receptor-binding protein 2 N-terminal src homology domain 3: effect of binding to a proline-rich peptide from guanine nucleotide exchange factor.	Proline	188-195	growth factor receptor bound protein 2	Homo sapiens	90-130
10928480-6	2000	DNA sequencing analysis revealed a novel missense mutation in the GPIbbeta gene that converts Pro (CCG) to Arg (CGG) at residue 74.	Proline	94-97	glycoprotein Ib platelet subunit alpha	Homo sapiens	66-74
10939594-0	2000	Phosphorylation-dependent proline isomerization catalyzed by Pin1 is essential for tumor cell survival and entry into mitosis.	Proline	26-33	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	61-65
10939594-3	2000	Pin1 recognizes phosphorylated serine-proline or threonine-proline peptide-bonds in test substrates up to 1300-fold better than in the respective unphosphorylated peptides.	Proline	38-45	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
10939594-3	2000	Pin1 recognizes phosphorylated serine-proline or threonine-proline peptide-bonds in test substrates up to 1300-fold better than in the respective unphosphorylated peptides.	Proline	59-66	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
10880969-6	2000	Altogether, our results suggest that KIS preferentially phosphorylates proline directed residues but has a specificity different from that of MAP kinases and cdks.	Proline	71-78	U2AF homology motif kinase 1	Homo sapiens	37-40
10871321-7	2000	BK1-5 (Arg-Pro-Pro-Gly-Phe), the 1-to-5 amino acid fragment of bradykinin, was identified as a major stable plasma metabolite of bradykinin.	Proline	11-14	bradykinin receptor B2	Homo sapiens	0-5
10871321-7	2000	BK1-5 (Arg-Pro-Pro-Gly-Phe), the 1-to-5 amino acid fragment of bradykinin, was identified as a major stable plasma metabolite of bradykinin.	Proline	11-14	kininogen 1	Homo sapiens	63-73
10871321-7	2000	BK1-5 (Arg-Pro-Pro-Gly-Phe), the 1-to-5 amino acid fragment of bradykinin, was identified as a major stable plasma metabolite of bradykinin.	Proline	11-14	kininogen 1	Homo sapiens	129-139
10871321-7	2000	BK1-5 (Arg-Pro-Pro-Gly-Phe), the 1-to-5 amino acid fragment of bradykinin, was identified as a major stable plasma metabolite of bradykinin.	Proline	15-18	bradykinin receptor B2	Homo sapiens	0-5
10871321-7	2000	BK1-5 (Arg-Pro-Pro-Gly-Phe), the 1-to-5 amino acid fragment of bradykinin, was identified as a major stable plasma metabolite of bradykinin.	Proline	15-18	kininogen 1	Homo sapiens	63-73
10871321-7	2000	BK1-5 (Arg-Pro-Pro-Gly-Phe), the 1-to-5 amino acid fragment of bradykinin, was identified as a major stable plasma metabolite of bradykinin.	Proline	15-18	kininogen 1	Homo sapiens	129-139
10864441-7	2000	IGF-I increased [(3)H]proline and [(35)S]sulfate incorporation in a dose-dependent manner in the presence or absence of compression, but the anabolic effect of the growth factor was lessened when the tissue was compressed by 50%.	Proline	22-29	insulin like growth factor 1	Bos taurus	0-5
10850990-4	2000	Put3p controls the expression of the proline utilization pathway that allows yeast cells to grow on proline as the sole nitrogen source.	Proline	37-44	Put3p	Saccharomyces cerevisiae S288C	0-5
10850990-4	2000	Put3p controls the expression of the proline utilization pathway that allows yeast cells to grow on proline as the sole nitrogen source.	Proline	100-107	Put3p	Saccharomyces cerevisiae S288C	0-5
10858458-4	2000	In vitro confrontation experiments showed that the SH3-N domain of SETA interacted with the proline-rich C terminus of AIP1.	Proline	92-99	SH3 domain-containing kinase-binding protein 1	Rattus norvegicus	67-71
10894149-0	2000	PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1).	Proline	8-15	nuclear receptor subfamily 5 group A member 1	Homo sapiens	158-185
10894149-0	2000	PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1).	Proline	8-15	estrogen related receptor alpha	Homo sapiens	202-235
10828491-10	2000	Similarly, CGRP reduced the absorption of proline and taurine by 20 and 11.5%, respectively.	Proline	42-49	calcitonin-related polypeptide alpha	Rattus norvegicus	11-15
10926119-4	2000	No mutation was detected in these genes although length polymorphisms in the proline-alanine repeat of the p57 gene were detected.	Proline	77-84	cyclin dependent kinase inhibitor 1C	Homo sapiens	107-110
10891119-8	2000	Polymers based on phenylalanine, tert-leucine, and proline were active as heparanase inhibitors and FGF release, and polymers of trans-hydroxyproline, glycine, and serine were active only as heparanase inhibitors.	Proline	51-58	fibroblast growth factor 2	Homo sapiens	100-103
10864917-3	2000	IL-1beta, and to a lesser extent TNF-alpha, decreased collagen synthesis, which was measured as collagenase-sensitive [(3)H]proline incorporation, but had no effect on cell number or total protein synthesis.	Proline	124-131	interleukin 1 beta	Rattus norvegicus	0-8
10864917-3	2000	IL-1beta, and to a lesser extent TNF-alpha, decreased collagen synthesis, which was measured as collagenase-sensitive [(3)H]proline incorporation, but had no effect on cell number or total protein synthesis.	Proline	124-131	tumor necrosis factor	Rattus norvegicus	33-42
10858458-4	2000	In vitro confrontation experiments showed that the SH3-N domain of SETA interacted with the proline-rich C terminus of AIP1.	Proline	92-99	programmed cell death 6 interacting protein	Rattus norvegicus	119-123
10858562-1	2000	The cloning of pyrroline 5-carboxylate reductase from Drosophila melanogaster was accomplished by cDNA complementation of an Escherichia coli proline auxotroph.	Proline	142-149	Pyrroline-5-carboxylate reductase-like 2	Drosophila melanogaster	15-48
10871864-8	2000	These results indicate that the proline residue at position 439 unlike arginine at position 429, may play a critical role in targeting Sam68 protein to nucleus.	Proline	32-39	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	135-140
10841982-0	2000	The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y is not associated with Alzheimer"s disease or the link apolipoprotein E.	Proline	19-26	neuropeptide Y	Homo sapiens	69-83
10860822-5	2000	In betaPix-c, 75 amino acid residues are deleted in the proline-rich region at the carboxyl-terminus of betaPix.	Proline	56-63	Rho guanine nucleotide exchange factor (GEF7)	Mus musculus	3-12
10860822-5	2000	In betaPix-c, 75 amino acid residues are deleted in the proline-rich region at the carboxyl-terminus of betaPix.	Proline	56-63	Rho guanine nucleotide exchange factor (GEF7)	Mus musculus	3-10
10837147-4	2000	Also contained within the LMP2A amino terminal domain are five proline-rich regions, three of which possess the PxxP core consensus sequence required for interacting with SH3 domains and two of which possess the PPxY core consensus sequence (PY motif) required for interacting with class I type WW domains.	Proline	63-70	LMP2A	Human gammaherpesvirus 4	26-31
10852705-12	2000	Moreover, these data established the importance of a Pro residue in the P3" position for efficient inhibition of catS by both wild-type SCCA1 and mutated SCCA2.	Proline	53-56	serpin family B member 3	Homo sapiens	136-141
10852705-12	2000	Moreover, these data established the importance of a Pro residue in the P3" position for efficient inhibition of catS by both wild-type SCCA1 and mutated SCCA2.	Proline	53-56	serpin family B member 4	Homo sapiens	154-159
10837147-8	2000	These data demonstrate that a subset of the conserved proline-rich motifs within the amino terminus of LMP2A can potentially mediate interactions with cellular proteins and may play a role in EBV-mediated latency and/or transformation.	Proline	54-61	LMP2A	Human gammaherpesvirus 4	103-108
10863096-3	2000	The deduced amino-acid sequence of the ME1 cDNA revealed that it consists of 149 amino acid residues, which contain a signal peptide characteristic of secretory proteins, six cysteine residues and a proline-rich region conserved in the orthologous proteins.	Proline	199-206	malic enzyme 1, NADP(+)-dependent, cytosolic	Mus musculus	39-42
11004527-1	2000	Aminopeptidase P (APP), dipeptidyl peptidase II (DP II), dipeptidyl peptidase IV (DP IV) and prolyl oligopeptidase (POP) are proline specific peptidases.	Proline	125-132	amyloid beta precursor protein	Homo sapiens	0-16
11004527-1	2000	Aminopeptidase P (APP), dipeptidyl peptidase II (DP II), dipeptidyl peptidase IV (DP IV) and prolyl oligopeptidase (POP) are proline specific peptidases.	Proline	125-132	dipeptidyl peptidase 7	Homo sapiens	24-47
11004527-1	2000	Aminopeptidase P (APP), dipeptidyl peptidase II (DP II), dipeptidyl peptidase IV (DP IV) and prolyl oligopeptidase (POP) are proline specific peptidases.	Proline	125-132	dipeptidyl peptidase 7	Homo sapiens	49-54
11004527-1	2000	Aminopeptidase P (APP), dipeptidyl peptidase II (DP II), dipeptidyl peptidase IV (DP IV) and prolyl oligopeptidase (POP) are proline specific peptidases.	Proline	125-132	dipeptidyl peptidase 4	Homo sapiens	57-80
11004527-1	2000	Aminopeptidase P (APP), dipeptidyl peptidase II (DP II), dipeptidyl peptidase IV (DP IV) and prolyl oligopeptidase (POP) are proline specific peptidases.	Proline	125-132	dipeptidyl peptidase 4	Homo sapiens	82-87
11004527-1	2000	Aminopeptidase P (APP), dipeptidyl peptidase II (DP II), dipeptidyl peptidase IV (DP IV) and prolyl oligopeptidase (POP) are proline specific peptidases.	Proline	125-132	prolyl endopeptidase	Homo sapiens	93-114
11004527-1	2000	Aminopeptidase P (APP), dipeptidyl peptidase II (DP II), dipeptidyl peptidase IV (DP IV) and prolyl oligopeptidase (POP) are proline specific peptidases.	Proline	125-132	prolyl endopeptidase	Homo sapiens	116-119
10856234-0	2000	SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55.	Proline	28-35	src kinase associated phosphoprotein 1	Homo sapiens	101-107
10856234-3	2000	In this study, we report SH3 domain binding to a novel proline-independent motif in immune cell adaptor SKAP55, which is comprised of two N-terminal lysine and arginine residues followed by two tyrosines (i.e. RKxxYxxY).	Proline	55-62	src kinase associated phosphoprotein 1	Homo sapiens	104-110
10850407-2	2000	The arginine allele at codon 72 of p53 was found to be more susceptible to degradation by HPV E6 protein than is the proline allele in vivo, thus resulting in a high frequency of cervical SCC in individuals homozygous for arginine at the codon.	Proline	117-124	tumor protein p53	Homo sapiens	35-38
10823914-1	2000	A subset of prolyl oligopeptidases, including dipeptidyl-peptidase IV (DPP IV or CD26, EC ), specifically cleave off N-terminal dipeptides from substrates having proline or alanine in amino acid position 2.	Proline	162-169	dipeptidylpeptidase 4	Mus musculus	46-69
10823914-1	2000	A subset of prolyl oligopeptidases, including dipeptidyl-peptidase IV (DPP IV or CD26, EC ), specifically cleave off N-terminal dipeptides from substrates having proline or alanine in amino acid position 2.	Proline	162-169	dipeptidylpeptidase 4	Mus musculus	71-77
10823914-1	2000	A subset of prolyl oligopeptidases, including dipeptidyl-peptidase IV (DPP IV or CD26, EC ), specifically cleave off N-terminal dipeptides from substrates having proline or alanine in amino acid position 2.	Proline	162-169	dipeptidylpeptidase 4	Mus musculus	81-85
10837380-6	2000	A heterozygous single base pair transition (CTG to CCG, leucine to proline) was detected in codon 518 of the betaig-h3 gene in the three affected members, and not in the unaffected member.	Proline	67-74	transforming growth factor beta induced	Homo sapiens	109-118
10882365-2	2000	Analogues of this potent B(1) bradykinin receptor antagonist in which the central Pro(2)-Hyp(3)-Gly(4)-Igl(5) tetrapeptide has been replaced by constrained N-1-substituted-1,3,8-triazaspiro?4.	Proline	82-85	bradykinin receptor B1	Homo sapiens	25-49
10823893-2	2000	In this paper, we report that PI3K-I(A), through its p85alpha subunit-SH3 domain, binds to a proline-rich region in the Na(+),K(+)-ATPase catalytic alpha subunit.	Proline	93-100	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	53-61
10834834-4	2000	Two of these genes, SUPPRESSOR OF OVEREXPRESSION OF CO 1 (SOC1) and FLOWERING LOCUS T (FT), are required for CO to promote flowering; the others are involved in proline or ethylene biosynthesis.	Proline	161-168	AGAMOUS-like 20	Arabidopsis thaliana	20-56
10834834-4	2000	Two of these genes, SUPPRESSOR OF OVEREXPRESSION OF CO 1 (SOC1) and FLOWERING LOCUS T (FT), are required for CO to promote flowering; the others are involved in proline or ethylene biosynthesis.	Proline	161-168	AGAMOUS-like 20	Arabidopsis thaliana	58-62
10834834-4	2000	Two of these genes, SUPPRESSOR OF OVEREXPRESSION OF CO 1 (SOC1) and FLOWERING LOCUS T (FT), are required for CO to promote flowering; the others are involved in proline or ethylene biosynthesis.	Proline	161-168	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	68-85
10834834-4	2000	Two of these genes, SUPPRESSOR OF OVEREXPRESSION OF CO 1 (SOC1) and FLOWERING LOCUS T (FT), are required for CO to promote flowering; the others are involved in proline or ethylene biosynthesis.	Proline	161-168	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	87-89
10850407-2	2000	The arginine allele at codon 72 of p53 was found to be more susceptible to degradation by HPV E6 protein than is the proline allele in vivo, thus resulting in a high frequency of cervical SCC in individuals homozygous for arginine at the codon.	Proline	117-124	serpin family B member 3	Homo sapiens	188-191
10830300-7	2000	The association between p85 and c-src is due in part to a direct interaction between the proline-rich sequences of p85 and the SH3 domain of c-src.	Proline	89-96	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	24-27
10830300-7	2000	The association between p85 and c-src is due in part to a direct interaction between the proline-rich sequences of p85 and the SH3 domain of c-src.	Proline	89-96	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	32-37
10830300-7	2000	The association between p85 and c-src is due in part to a direct interaction between the proline-rich sequences of p85 and the SH3 domain of c-src.	Proline	89-96	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	115-118
10830300-7	2000	The association between p85 and c-src is due in part to a direct interaction between the proline-rich sequences of p85 and the SH3 domain of c-src.	Proline	89-96	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	141-146
10806096-2	2000	Shank polypeptides contain multiple sites for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PDZ domain, a long proline-rich region, and a SAM domain.	Proline	138-145	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	0-5
10833024-6	2000	Examination of the ions from collision induced fragmentation disclosed that this substance was the N-terminal tryptic fragment of Endo VIII cross-linked to a portion of the oligomer, and that the N-terminal proline from Endo VIII was covalently bound to the residual deoxyribose moiety at the original location of the thymine glycol in the oligomer.	Proline	207-214	cytochrome c oxidase subunit 8A	Homo sapiens	225-229
10872802-4	2000	APS contains a proline-rich region, PH and SH2 domains, and a putative tyrosine phosphorylation site at the C-terminal, and the overall structure resembles those of Lnk and SH2-B.	Proline	15-22	SH2B adaptor protein 2	Mus musculus	0-3
10852461-0	2000	Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects.	Proline	13-20	neuropeptide Y	Homo sapiens	43-57
10828094-9	2000	The binding of LDL to Lp[a]/apo[a] was inhibited by L-proline and lysine analogs, which are known to inhibit the non-covalent association between apo[a] and apoB.	Proline	52-61	apolipoprotein B	Homo sapiens	157-161
10799567-7	2000	We have also investigated the functional significance of two structural motifs within the DNA binding and dimerization domains of EBNA1, the proline loop and the WF motif.	Proline	141-148	EBNA-1	Human gammaherpesvirus 4	130-135
10891598-2	2000	By the Spot multiple peptide synthesis method, we showed that Tyr-394, Ser(P)-396 and Pro-397 are critical for AD2 binding.	Proline	86-89	apolipoprotein E	Homo sapiens	111-114
10748127-2	2000	Here we demonstrate that the proposed adapter protein for Src kinases, Sam68, is a ligand whose proline-rich motifs interact with the SH3 domains of p59(fyn) and phospholipase Cgamma-1 as well as with the WW domains of FBP30 and FBP21.	Proline	96-103	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	71-76
10748127-2	2000	Here we demonstrate that the proposed adapter protein for Src kinases, Sam68, is a ligand whose proline-rich motifs interact with the SH3 domains of p59(fyn) and phospholipase Cgamma-1 as well as with the WW domains of FBP30 and FBP21.	Proline	96-103	HLA complex P5B	Homo sapiens	149-152
10748127-2	2000	Here we demonstrate that the proposed adapter protein for Src kinases, Sam68, is a ligand whose proline-rich motifs interact with the SH3 domains of p59(fyn) and phospholipase Cgamma-1 as well as with the WW domains of FBP30 and FBP21.	Proline	96-103	formin binding protein 4	Homo sapiens	219-224
10748127-2	2000	Here we demonstrate that the proposed adapter protein for Src kinases, Sam68, is a ligand whose proline-rich motifs interact with the SH3 domains of p59(fyn) and phospholipase Cgamma-1 as well as with the WW domains of FBP30 and FBP21.	Proline	96-103	WW domain binding protein 4	Homo sapiens	229-234
10826481-2	2000	Additional mutagenesis indicates that important residues in this region for CCR5 binding are Ile-420, Lys-421, Gln-422, Pro-438, and Gly-441.	Proline	120-123	C-C motif chemokine receptor 5	Homo sapiens	76-80
10799879-3	2000	hLnk has a calculated molecular mass of 63 kDa, and its deduced amino acid sequence indicates the presence of an N-terminal proline-rich region, a pleckstrin homology domain, and a Src homology 2 domain.	Proline	124-131	SH2B adaptor protein 3	Homo sapiens	0-4
10801361-0	2000	Coupled kinetic traps in cytochrome c folding: His-heme misligation and proline isomerization.	Proline	72-79	cytochrome c, somatic	Equus caballus	25-37
10814512-5	2000	The proline-rich formin homology 1 domain of mDia1 bound the Src homology 3 domain of IRSp53/BAIAP2 in a GTP-Rho-dependent manner.	Proline	4-11	diaphanous related formin 1	Mus musculus	45-50
10814512-5	2000	The proline-rich formin homology 1 domain of mDia1 bound the Src homology 3 domain of IRSp53/BAIAP2 in a GTP-Rho-dependent manner.	Proline	4-11	BAR/IMD domain containing adaptor protein 2	Homo sapiens	86-92
10814512-5	2000	The proline-rich formin homology 1 domain of mDia1 bound the Src homology 3 domain of IRSp53/BAIAP2 in a GTP-Rho-dependent manner.	Proline	4-11	BAR/IMD domain containing adaptor protein 2	Homo sapiens	93-99
10799562-7	2000	p130(CAS) was also found to associate with the p85 subunit of PI 3-kinase through its proline-rich domain during virus internalization and expression of p130(CAS) containing a deleted proline-rich domain (PRD) inhibited adenovirus cell entry.	Proline	86-93	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	0-4
10831834-11	2000	For example, a glycine/proline-rich domain in the central variable region functions to recruit the histone deacetylase Rpd3 to the template.	Proline	23-30	histone deacetylase 3	Homo sapiens	119-123
10799523-5	2000	Further, overproduction of Ure2p nearly eliminates NCR-sensitive transcription under derepressive growth conditions, i.e. with proline as the sole nitrogen source.	Proline	127-134	glutathione peroxidase	Saccharomyces cerevisiae S288C	27-32
10843813-2	2000	Here we have identified a novel human cDNA encoding NRBP, a multidomain putative adapter protein containing (i) two putative nuclear receptor binding motifs (LXXLL), (ii) a putative binding domain for Src homology-2 (SH2) domain containing proteins, (iii) a kinase-like domain, (iv) a bipartite nuclear localization signal, and (v) three sequences rich in glutamic acid, serine, proline, and threonine (PEST) residues.	Proline	379-386	nuclear receptor binding protein 1	Homo sapiens	52-56
10799562-7	2000	p130(CAS) was also found to associate with the p85 subunit of PI 3-kinase through its proline-rich domain during virus internalization and expression of p130(CAS) containing a deleted proline-rich domain (PRD) inhibited adenovirus cell entry.	Proline	86-93	BCAR1 scaffold protein, Cas family member	Homo sapiens	5-8
10799562-7	2000	p130(CAS) was also found to associate with the p85 subunit of PI 3-kinase through its proline-rich domain during virus internalization and expression of p130(CAS) containing a deleted proline-rich domain (PRD) inhibited adenovirus cell entry.	Proline	86-93	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	47-50
10747847-5	2000	A central proline-rich motif associated with the Src homology (SH)2/SH3-containing adapter proteins Grb2 and Nck in vivo, whereas a pleckstrin homology (PH) domain was located at the GEF C terminus.	Proline	10-17	growth factor receptor bound protein 2	Homo sapiens	100-104
10799562-7	2000	p130(CAS) was also found to associate with the p85 subunit of PI 3-kinase through its proline-rich domain during virus internalization and expression of p130(CAS) containing a deleted proline-rich domain (PRD) inhibited adenovirus cell entry.	Proline	184-191	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	0-4
10799562-7	2000	p130(CAS) was also found to associate with the p85 subunit of PI 3-kinase through its proline-rich domain during virus internalization and expression of p130(CAS) containing a deleted proline-rich domain (PRD) inhibited adenovirus cell entry.	Proline	184-191	BCAR1 scaffold protein, Cas family member	Homo sapiens	5-8
10799562-7	2000	p130(CAS) was also found to associate with the p85 subunit of PI 3-kinase through its proline-rich domain during virus internalization and expression of p130(CAS) containing a deleted proline-rich domain (PRD) inhibited adenovirus cell entry.	Proline	184-191	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	47-50
10799562-7	2000	p130(CAS) was also found to associate with the p85 subunit of PI 3-kinase through its proline-rich domain during virus internalization and expression of p130(CAS) containing a deleted proline-rich domain (PRD) inhibited adenovirus cell entry.	Proline	184-191	BCAR1 scaffold protein, Cas family member	Homo sapiens	158-161
10799562-8	2000	We showed further that the RPLPSPP motif in the proline-rich region of p130(CAS) interacts with the SH3 domain of p85/PI 3-kinase.	Proline	48-55	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	71-75
10799562-8	2000	We showed further that the RPLPSPP motif in the proline-rich region of p130(CAS) interacts with the SH3 domain of p85/PI 3-kinase.	Proline	48-55	BCAR1 scaffold protein, Cas family member	Homo sapiens	76-79
10799562-8	2000	We showed further that the RPLPSPP motif in the proline-rich region of p130(CAS) interacts with the SH3 domain of p85/PI 3-kinase.	Proline	48-55	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	114-117
10805775-0	2000	Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease.	Proline	11-18	membrane bound transcription factor peptidase, site 2	Homo sapiens	105-120
10812060-6	2000	Firstly, 26 kDa human, mouse and rat proSAAS, like all vertebrate 7B2s, contain a proline-rich sequence within the first half of the molecule and also contain a C-terminal 40 residue peptide (SAAS CT peptide) separated from the remainder of the protein by a furin consensus sequence.	Proline	82-89	proSAAS	Rattus norvegicus	37-44
10805775-5	2000	We propose a model in which the asparagine-proline sequence serves as an NH(2)-terminal cap for a portion of the transmembrane alpha-helix of SREBP, allowing the remainder of the alpha-helix to unwind partially to expose the peptide bond for cleavage by S2P.	Proline	43-50	membrane bound transcription factor peptidase, site 2	Homo sapiens	254-257
10747847-5	2000	A central proline-rich motif associated with the Src homology (SH)2/SH3-containing adapter proteins Grb2 and Nck in vivo, whereas a pleckstrin homology (PH) domain was located at the GEF C terminus.	Proline	10-17	NCK adaptor protein 1	Homo sapiens	109-112
10813720-3	2000	RESULTS: Among these polymorphisms, the individuals carrying arginine/proline genotypes of p53 showed a 9.5-fold increase of cervical carcinoma risk (95% confidence interval [CI], 4.9-18.6) compared with those individuals carrying arginine/arginine genotypes.	Proline	70-77	tumor protein p53	Homo sapiens	91-94
10794688-0	2000	New proline mimetics: synthesis of thrombin inhibitors incorporating cyclopentane- and cyclopentenedicarboxylic acid templates in the P2 position.	Proline	4-11	coagulation factor II, thrombin	Homo sapiens	35-43
10807596-7	2000	Cells grown in high glucose demonstrated increased responsiveness to a relatively small dose of exogenous TGF-beta(1) (0.5 ng/ml): [(3)H]proline incorporation and alpha(1)(IV) collagen mRNA were significantly greater in cells cultured in high than in normal glucose.	Proline	137-144	transforming growth factor, beta 1	Mus musculus	106-117
10813720-6	2000	The individuals carrying both the arginine/proline genotype of p53 and the null genotype of GSTT1 showed a 3.5-fold increase of cervical carcinoma risk (95% CI, 1.8-7.1) compared with those individuals carrying both the arginine/arginine genotype of p53 and the GSTT1 positive genotype.	Proline	43-50	tumor protein p53	Homo sapiens	63-66
10813720-9	2000	CONCLUSIONS: The results of the current study suggested that the arginine/proline genotype of p53, independently or in conjunction with the GSTT1 null genotype, could affect the genetic susceptibility for cervical carcinoma, and HPV positive women carrying both null genotypes of GSTT1 and GSTM1 have an increased risk of cervical carcinoma developing before age 40 years.	Proline	74-81	tumor protein p53	Homo sapiens	94-97
10813720-9	2000	CONCLUSIONS: The results of the current study suggested that the arginine/proline genotype of p53, independently or in conjunction with the GSTT1 null genotype, could affect the genetic susceptibility for cervical carcinoma, and HPV positive women carrying both null genotypes of GSTT1 and GSTM1 have an increased risk of cervical carcinoma developing before age 40 years.	Proline	74-81	glutathione S-transferase theta 1	Homo sapiens	280-285
10813720-9	2000	CONCLUSIONS: The results of the current study suggested that the arginine/proline genotype of p53, independently or in conjunction with the GSTT1 null genotype, could affect the genetic susceptibility for cervical carcinoma, and HPV positive women carrying both null genotypes of GSTT1 and GSTM1 have an increased risk of cervical carcinoma developing before age 40 years.	Proline	74-81	glutathione S-transferase mu 1	Homo sapiens	290-295
10879451-7	2000	The correlations between the Lactate Pro and the ABL 700 Series Acid-Base analyser, YSI 2300 and Accusport were r = 0.98, r = 0.99, r = 0.97.	Proline	37-40	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	49-52
10788507-1	2000	Grb2-associated binder-1 (Gab1) is a multisite docking protein containing a pleckstrin homology (PH) domain, multiple potential tyrosine phosphorylation sites, and several proline-rich sequences.	Proline	172-179	GRB2 associated binding protein 1	Homo sapiens	0-24
10788507-1	2000	Grb2-associated binder-1 (Gab1) is a multisite docking protein containing a pleckstrin homology (PH) domain, multiple potential tyrosine phosphorylation sites, and several proline-rich sequences.	Proline	172-179	GRB2 associated binding protein 1	Homo sapiens	26-30
10867876-6	2000	The presumptive 44-kDa protein encoded by the plus-chain (sense) open reading frame contained serine-, proline-, and threonine-rich regions and was 25 to 30% homologous to a number of nuclear DNA-binding proteins of eukaryotes.	Proline	103-110	polymerase (RNA) III (DNA directed) polypeptide D	Mus musculus	16-22
10775606-8	2000	The deletion analysis of the p53 protein shows that the RPA binding, proline-rich regulatory, DNA-binding, and oligomerization domains are necessary for p53 action in both replication systems.	Proline	69-76	tumor protein p53	Homo sapiens	29-32
10791986-8	2000	We report that binding of the SH3 domain of p130Cas to proline-rich region 1 of FAK is required to support survival of fibroblasts on fibronectin when serum is withdrawn.	Proline	55-62	BCAR1 scaffold protein, Cas family member	Homo sapiens	44-51
10791986-8	2000	We report that binding of the SH3 domain of p130Cas to proline-rich region 1 of FAK is required to support survival of fibroblasts on fibronectin when serum is withdrawn.	Proline	55-62	protein tyrosine kinase 2	Homo sapiens	80-83
10791986-8	2000	We report that binding of the SH3 domain of p130Cas to proline-rich region 1 of FAK is required to support survival of fibroblasts on fibronectin when serum is withdrawn.	Proline	55-62	fibronectin 1	Homo sapiens	134-145
10769202-3	2000	Storage of the truncated GLUT4 in the GSC is restored by substitution of Phe for the Tyr(502) residue adjacent to Pro(505) or by treatment of cells with the tyrosine kinase inhibitor genistein.	Proline	114-117	solute carrier family 2 member 4	Homo sapiens	25-30
10775606-8	2000	The deletion analysis of the p53 protein shows that the RPA binding, proline-rich regulatory, DNA-binding, and oligomerization domains are necessary for p53 action in both replication systems.	Proline	69-76	tumor protein p53	Homo sapiens	153-156
10802655-3	2000	The binding of such mutants is influenced by whether TP53 (encoding p53) codon 72, by virtue of a common polymorphism in the human population, encodes Arg or Pro.	Proline	158-161	tumor protein p53	Homo sapiens	53-57
10793130-3	2000	Expression of truncated fibrillin-1 proteins in Chinese hamster ovary cells localized proteoglycan binding to an amino-terminal region near the proline-rich domain.	Proline	144-151	fibrillin-1	Cricetulus griseus	24-35
10757802-2	2000	Here we show that Evi9 encodes a novel zinc finger protein with three tissue-specific isoforms: Evi9a (773 amino acids [aa]) contains two C(2)H(2)-type zinc finger motifs, a proline-rich region, and an acidic domain; Evi9b (486 aa) lacks the first zinc finger motif and part of the proline-rich region; Evi9c (239 aa) lacks all but the first zinc finger motif.	Proline	174-181	BAF chromatin remodeling complex subunit BCL11A	Homo sapiens	18-22
10757802-2	2000	Here we show that Evi9 encodes a novel zinc finger protein with three tissue-specific isoforms: Evi9a (773 amino acids [aa]) contains two C(2)H(2)-type zinc finger motifs, a proline-rich region, and an acidic domain; Evi9b (486 aa) lacks the first zinc finger motif and part of the proline-rich region; Evi9c (239 aa) lacks all but the first zinc finger motif.	Proline	174-181	B cell CLL/lymphoma 11A (zinc finger protein)	Mus musculus	96-101
10757802-2	2000	Here we show that Evi9 encodes a novel zinc finger protein with three tissue-specific isoforms: Evi9a (773 amino acids [aa]) contains two C(2)H(2)-type zinc finger motifs, a proline-rich region, and an acidic domain; Evi9b (486 aa) lacks the first zinc finger motif and part of the proline-rich region; Evi9c (239 aa) lacks all but the first zinc finger motif.	Proline	282-289	BAF chromatin remodeling complex subunit BCL11A	Homo sapiens	18-22
10757802-2	2000	Here we show that Evi9 encodes a novel zinc finger protein with three tissue-specific isoforms: Evi9a (773 amino acids [aa]) contains two C(2)H(2)-type zinc finger motifs, a proline-rich region, and an acidic domain; Evi9b (486 aa) lacks the first zinc finger motif and part of the proline-rich region; Evi9c (239 aa) lacks all but the first zinc finger motif.	Proline	282-289	B cell CLL/lymphoma 11A (zinc finger protein)	Mus musculus	96-101
10802655-3	2000	The binding of such mutants is influenced by whether TP53 (encoding p53) codon 72, by virtue of a common polymorphism in the human population, encodes Arg or Pro.	Proline	158-161	tumor protein p53	Homo sapiens	68-71
10777567-1	2000	The COOH-terminal domain of the NR2D subunit of the NMDA receptor contains proline-rich regions that show striking homology to sequences known to bind to Src homology 3 (SH3) domains.	Proline	75-82	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	Mus musculus	32-36
10756197-6	2000	We demonstrate that the KLF8 Pro-Val-Asp-Leu-Ser motif also contacts CtBP.	Proline	29-32	Kruppel like factor 8	Homo sapiens	24-28
10823288-0	2000	Influence of the nt 2148 A to G substitution (Pro 626 dimorphism) in the PROS1 gene on circulating free protein S levels in healthy volunteers--reappraisal of protein S normal ranges.	Proline	46-49	protein S	Homo sapiens	73-78
10777567-2	2000	To determine whether the proline-rich region of the NR2D subunit interacts with specific SH3 domains, in vitro SH3 domain binding assays were performed.	Proline	25-32	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	Mus musculus	52-56
10777567-3	2000	A proline-rich fragment of the NR2D subunit (2D(866-1064)) bound to the Abl SH3 domain but not to the SH3 domains from Src, Fyn, Grb2, GAP, or phospholipase C-gamma (PLCgamma).	Proline	2-9	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	Mus musculus	31-35
10777567-3	2000	A proline-rich fragment of the NR2D subunit (2D(866-1064)) bound to the Abl SH3 domain but not to the SH3 domains from Src, Fyn, Grb2, GAP, or phospholipase C-gamma (PLCgamma).	Proline	2-9	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	72-75
10822372-4	2000	This kinase appears to have at least two binding sites on c-Rel, a proline-directed serine/ threonine substrate specificity similar to MAP kinases and to specifically phosphorylate the C-terminal domain of murine c-Rel at an ERK consensus site.	Proline	67-74	reticuloendotheliosis oncogene	Mus musculus	58-63
10822372-4	2000	This kinase appears to have at least two binding sites on c-Rel, a proline-directed serine/ threonine substrate specificity similar to MAP kinases and to specifically phosphorylate the C-terminal domain of murine c-Rel at an ERK consensus site.	Proline	67-74	reticuloendotheliosis oncogene	Mus musculus	213-218
10757979-0	2000	Solution structure of Eps15"s third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites.	Proline	81-84	epidermal growth factor receptor pathway substrate 15	Homo sapiens	22-27
10772915-0	2000	Measurement of 5-hydroxy-2-aminovaleric acid as a specific marker of iron-mediated oxidation of proline and arginine side-chain residues of low-density lipoprotein apolipoprotein B-100.	Proline	96-103	apolipoprotein B	Homo sapiens	164-184
10772915-5	2000	Results suggest that apoB-100 proline and arginine residues are highly reactive toward oxygen radicals ex vivo.	Proline	30-37	apolipoprotein B	Homo sapiens	21-29
10781813-4	2000	DroVav preserves the unique, complex structure of hVav proteins, including the "calponin homology", dbl homology, pleckstrin homology; SH2 and SH3 domains in addition to regions that are acidic rich, proline rich and cysteine rich.	Proline	200-207	Vav guanine nucleotide exchange factor	Drosophila melanogaster	0-6
10781813-4	2000	DroVav preserves the unique, complex structure of hVav proteins, including the "calponin homology", dbl homology, pleckstrin homology; SH2 and SH3 domains in addition to regions that are acidic rich, proline rich and cysteine rich.	Proline	200-207	vav guanine nucleotide exchange factor 1	Homo sapiens	50-54
10749687-12	2000	With the use of glutathione S-transferase fusion proteins containing Shc-SH2, Grb2-SH2, and Grb2 N-terminal and C-terminal SH3 domains, it was implied that the proline-rich region of Pyk2 (and FAK) binds to the N-terminal SH3 domain of Grb2 and that the phosphotyrosine residue of Shc binds to the SH2 domain of Grb2.	Proline	160-167	SHC adaptor protein 1	Homo sapiens	69-72
10780900-1	2000	Three [5-t-BuPro(7)]oxytocin analogues were synthesized by substituting (2S,5R)-5-tert-butylproline for proline in oxytocin, [Mpa(1)]oxytocin, and [dPen(1)]oxytocin.	Proline	92-99	oxytocin/neurophysin I prepropeptide	Homo sapiens	20-28
10780900-5	2000	Assignment of the proton signals for the 5-tert-butylprolyl amide cis- and trans-isomers by two-dimensional NMR experiments in water indicated that the Cys(6)-Pro(7) peptide bond cis-isomer population was augmented relative to the prolyl peptides and measured respectively at 35%, 33%, and 20% in the 5-tert-butylproline(7) analogues of oxytocin, [Mpa(1)]oxytocin and [dPen(1)]oxytocin.	Proline	159-162	oxytocin/neurophysin I prepropeptide	Homo sapiens	337-345
10780900-5	2000	Assignment of the proton signals for the 5-tert-butylprolyl amide cis- and trans-isomers by two-dimensional NMR experiments in water indicated that the Cys(6)-Pro(7) peptide bond cis-isomer population was augmented relative to the prolyl peptides and measured respectively at 35%, 33%, and 20% in the 5-tert-butylproline(7) analogues of oxytocin, [Mpa(1)]oxytocin and [dPen(1)]oxytocin.	Proline	159-162	oxytocin/neurophysin I prepropeptide	Homo sapiens	355-363
10780900-5	2000	Assignment of the proton signals for the 5-tert-butylprolyl amide cis- and trans-isomers by two-dimensional NMR experiments in water indicated that the Cys(6)-Pro(7) peptide bond cis-isomer population was augmented relative to the prolyl peptides and measured respectively at 35%, 33%, and 20% in the 5-tert-butylproline(7) analogues of oxytocin, [Mpa(1)]oxytocin and [dPen(1)]oxytocin.	Proline	159-162	oxytocin/neurophysin I prepropeptide	Homo sapiens	355-363
10780900-0	2000	A study of the relationship between biological activity and prolyl amide isomer geometry in oxytocin using 5-tert-butylproline to augment the Cys(6)-Pro(7) amide cis-isomer population.	Proline	149-152	oxytocin/neurophysin I prepropeptide	Homo sapiens	92-100
10749687-12	2000	With the use of glutathione S-transferase fusion proteins containing Shc-SH2, Grb2-SH2, and Grb2 N-terminal and C-terminal SH3 domains, it was implied that the proline-rich region of Pyk2 (and FAK) binds to the N-terminal SH3 domain of Grb2 and that the phosphotyrosine residue of Shc binds to the SH2 domain of Grb2.	Proline	160-167	growth factor receptor bound protein 2	Homo sapiens	78-82
10754328-5	2000	Although I kappa B alpha was phosphorylated upon exposure to H2O2, tyrosine residue 42 and the C-terminal PEST (proline-glutamic acid-serine-threonine) domain played an important role.	Proline	112-119	NFKB inhibitor alpha	Homo sapiens	9-24
10749687-12	2000	With the use of glutathione S-transferase fusion proteins containing Shc-SH2, Grb2-SH2, and Grb2 N-terminal and C-terminal SH3 domains, it was implied that the proline-rich region of Pyk2 (and FAK) binds to the N-terminal SH3 domain of Grb2 and that the phosphotyrosine residue of Shc binds to the SH2 domain of Grb2.	Proline	160-167	growth factor receptor bound protein 2	Homo sapiens	92-96
10749687-12	2000	With the use of glutathione S-transferase fusion proteins containing Shc-SH2, Grb2-SH2, and Grb2 N-terminal and C-terminal SH3 domains, it was implied that the proline-rich region of Pyk2 (and FAK) binds to the N-terminal SH3 domain of Grb2 and that the phosphotyrosine residue of Shc binds to the SH2 domain of Grb2.	Proline	160-167	protein tyrosine kinase 2 beta	Homo sapiens	183-187
10749687-12	2000	With the use of glutathione S-transferase fusion proteins containing Shc-SH2, Grb2-SH2, and Grb2 N-terminal and C-terminal SH3 domains, it was implied that the proline-rich region of Pyk2 (and FAK) binds to the N-terminal SH3 domain of Grb2 and that the phosphotyrosine residue of Shc binds to the SH2 domain of Grb2.	Proline	160-167	protein tyrosine kinase 2	Homo sapiens	193-196
10749687-12	2000	With the use of glutathione S-transferase fusion proteins containing Shc-SH2, Grb2-SH2, and Grb2 N-terminal and C-terminal SH3 domains, it was implied that the proline-rich region of Pyk2 (and FAK) binds to the N-terminal SH3 domain of Grb2 and that the phosphotyrosine residue of Shc binds to the SH2 domain of Grb2.	Proline	160-167	growth factor receptor bound protein 2	Homo sapiens	92-96
10749687-12	2000	With the use of glutathione S-transferase fusion proteins containing Shc-SH2, Grb2-SH2, and Grb2 N-terminal and C-terminal SH3 domains, it was implied that the proline-rich region of Pyk2 (and FAK) binds to the N-terminal SH3 domain of Grb2 and that the phosphotyrosine residue of Shc binds to the SH2 domain of Grb2.	Proline	160-167	SHC adaptor protein 1	Homo sapiens	281-284
10749687-12	2000	With the use of glutathione S-transferase fusion proteins containing Shc-SH2, Grb2-SH2, and Grb2 N-terminal and C-terminal SH3 domains, it was implied that the proline-rich region of Pyk2 (and FAK) binds to the N-terminal SH3 domain of Grb2 and that the phosphotyrosine residue of Shc binds to the SH2 domain of Grb2.	Proline	160-167	growth factor receptor bound protein 2	Homo sapiens	92-96
10786691-9	2000	RXRalpha was found to contain two proline, glutamate/aspartate, serine, and threonine (PEST) motifs, which confer rapid turnover of many short-lived regulatory proteins that are degraded by the ubiquitin/proteasome pathway.	Proline	34-41	retinoid X receptor alpha	Homo sapiens	0-8
10753943-5	2000	This recruitment of c-SRC to the receptor involves an interaction between the amino-terminal proline-rich region of beta-arrestin1 and the Src homology 3 (SH3) domain of c-SRC, but deletion of the proline-rich domain does not totally ablate the interaction.	Proline	93-100	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	20-25
10753918-10	2000	These mutants define discrete subregions of a novel proline-rich domain that is required for subcellular localization and signal transduction by the LTbetaR.	Proline	52-59	lymphotoxin beta receptor	Homo sapiens	149-156
10753886-2	2000	A reverse transcriptase-polymerase chain reaction analysis of mRNA from mouse Purkinje cells revealed a predominant expression of the alpha1A channel lacking an asparagine-proline (NP) stretch in the domain IV (alpha1A(-NP)).	Proline	172-179	B cell leukemia/lymphoma 2 related protein A1a	Mus musculus	134-141
10753886-2	2000	A reverse transcriptase-polymerase chain reaction analysis of mRNA from mouse Purkinje cells revealed a predominant expression of the alpha1A channel lacking an asparagine-proline (NP) stretch in the domain IV (alpha1A(-NP)).	Proline	172-179	B cell leukemia/lymphoma 2 related protein A1a	Mus musculus	211-218
10753943-5	2000	This recruitment of c-SRC to the receptor involves an interaction between the amino-terminal proline-rich region of beta-arrestin1 and the Src homology 3 (SH3) domain of c-SRC, but deletion of the proline-rich domain does not totally ablate the interaction.	Proline	93-100	arrestin beta 1	Homo sapiens	116-130
10753943-5	2000	This recruitment of c-SRC to the receptor involves an interaction between the amino-terminal proline-rich region of beta-arrestin1 and the Src homology 3 (SH3) domain of c-SRC, but deletion of the proline-rich domain does not totally ablate the interaction.	Proline	197-204	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	20-25
10744752-4	2000	We show by two-dimensional NMR spectroscopy that the PIN1At is a prolyl cis/trans isomerase with specificity for phosphoserine-proline bonds.	Proline	127-134	Auxin efflux carrier family protein	Arabidopsis thaliana	53-57
10742606-9	2000	We also studied several peptides related to bradykinin, and the results emphasized the formation of turns involving the proline residues and the decrease of conformational flexibility induced by using TFE as the solvent.	Proline	120-127	kininogen 1	Homo sapiens	44-54
10744703-5	2000	In contrast with wild-type receptors, mutant P2X(2) receptors with truncated C terminus exhibited variable cell-specific kinetics with quickly desensitizing currents converted to slowly desensitizing currents by phorbol ester-mediated stimulation of protein kinase C. Phosphorylation of Thr(18) was demonstrated directly by immunodetection using specific monoclonal antibodies directed against the phosphothreonine-proline motif.	Proline	415-422	purinergic receptor P2X 2	Homo sapiens	45-51
10744628-0	2000	Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression.	Proline	21-28	solute carrier family 6 member 3	Homo sapiens	0-20
10749777-3	2000	Moreover, a proportion of kinin peptides is hydroxylated on proline(3) of the bradykinin sequence.	Proline	60-67	kininogen 1	Homo sapiens	78-88
10733484-10	2000	The proband and her GCS- deficient grandson were identified as homozygous for a 473C-->T substitution, changing codon 158 from CCC for proline into CTC for leucine.	Proline	135-142	glutamate-cysteine ligase catalytic subunit	Homo sapiens	20-23
10794489-1	2000	A case-control study was performed to investigate the risk of cervical cancer associated with p53 polymorphism at codon 72, encoding either arginine or proline.	Proline	152-159	tumor protein p53	Homo sapiens	94-97
10744628-12	2000	These DAT proline mutants identify DAT regions likely for dopamine translocation and for recognition of dopamine and cocaine.	Proline	10-17	solute carrier family 6 member 3	Homo sapiens	6-9
10744628-12	2000	These DAT proline mutants identify DAT regions likely for dopamine translocation and for recognition of dopamine and cocaine.	Proline	10-17	solute carrier family 6 member 3	Homo sapiens	35-38
10744628-3	2000	DAT proline residues, especially those in transmembrane (TM) domains, are good candidates for involvement in these DAT actions.	Proline	4-11	solute carrier family 6 member 3	Homo sapiens	0-3
10744628-3	2000	DAT proline residues, especially those in transmembrane (TM) domains, are good candidates for involvement in these DAT actions.	Proline	4-11	solute carrier family 6 member 3	Homo sapiens	115-118
10890533-5	2000	Of these, eight had high homology to lipid transfer protein (LTP), two were similar to glycine-rich protein (GRP), and one displayed high homology to proline-rich proteins from Arabidopsis thaliana (AtPRP2, AtPRP4) and from potato guard cells (GPP).	Proline	150-157	proline-rich protein 2	Arabidopsis thaliana	199-205
10826882-0	2000	Solution structure of the human BTK SH3 domain complexed with a proline-rich peptide from p120cbl.	Proline	64-71	Bruton tyrosine kinase	Homo sapiens	32-35
10826882-8	2000	We have also determined that the proline-rich peptide from p120cbl binds to BTK SH3 domain in a class I orientation.	Proline	33-40	Bruton tyrosine kinase	Homo sapiens	76-79
10737616-8	2000	The MAP kinases may not be strictly proline specific: p38 phosphorylated the nonproline sites Ser185, Thr245, Ser305, and Ser356, whereas ERK2 was the most strict.	Proline	36-43	mitogen-activated protein kinase 1	Homo sapiens	54-57
10764144-5	2000	We found that the SH3 domains of EEN and Abi-1 interact with different proline-rich domains of synaptojanin while the EH domains of Eps15 interact with the NPF motifs of synaptojanin.	Proline	71-78	abl interactor 1	Homo sapiens	41-46
10719058-4	2000	It was revealed that the arginine form of p53 is more susceptible to degradation by the HPV E6 protein than the proline form and that patients with the arginine form have a higher risk of developing cancer than those with the proline form.	Proline	112-119	tumor protein p53	Homo sapiens	42-45
10719058-4	2000	It was revealed that the arginine form of p53 is more susceptible to degradation by the HPV E6 protein than the proline form and that patients with the arginine form have a higher risk of developing cancer than those with the proline form.	Proline	226-233	tumor protein p53	Homo sapiens	42-45
10749935-3	2000	The AZU-1 gene encodes an acidic 571-amino-acid protein containing at least two structurally distinct domains with potential protein-binding functions: an N-terminal serine and proline-rich domain with a predicted immunoglobulin-like fold and a C-terminal coiled-coil domain.	Proline	177-184	transforming acidic coiled-coil containing protein 2	Homo sapiens	4-9
10798399-1	2000	Homer EVH1 (Ena/VASP Homology 1) domains interact with proline-rich motifs in the cytoplasmic regions of group 1 metabotropic glutamate receptors (mGluRs), inositol-1,4,5-trisphosphate receptors (IP3Rs), and Shank proteins.	Proline	55-62	ENAH actin regulator	Homo sapiens	12-31
10798399-1	2000	Homer EVH1 (Ena/VASP Homology 1) domains interact with proline-rich motifs in the cytoplasmic regions of group 1 metabotropic glutamate receptors (mGluRs), inositol-1,4,5-trisphosphate receptors (IP3Rs), and Shank proteins.	Proline	55-62	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	208-213
10759508-0	2000	Removal of feedback inhibition of delta(1)-pyrroline-5-carboxylate synthetase results in increased proline accumulation and protection of plants from osmotic stress.	Proline	99-106	delta-1-pyrroline-5-carboxylate synthase-like	Nicotiana tabacum	34-77
10759508-1	2000	The Delta(1)-pyrroline-5-carboxylate synthetase (P5CS; EC not assigned) is the rate-limiting enzyme in proline (Pro) biosynthesis in plants and is subject to feedback inhibition by Pro.	Proline	103-110	delta-1-pyrroline-5-carboxylate synthase-like	Nicotiana tabacum	4-47
10759508-1	2000	The Delta(1)-pyrroline-5-carboxylate synthetase (P5CS; EC not assigned) is the rate-limiting enzyme in proline (Pro) biosynthesis in plants and is subject to feedback inhibition by Pro.	Proline	103-110	delta-1-pyrroline-5-carboxylate synthase-like	Nicotiana tabacum	49-53
10759508-1	2000	The Delta(1)-pyrroline-5-carboxylate synthetase (P5CS; EC not assigned) is the rate-limiting enzyme in proline (Pro) biosynthesis in plants and is subject to feedback inhibition by Pro.	Proline	112-115	delta-1-pyrroline-5-carboxylate synthase-like	Nicotiana tabacum	4-47
10759508-1	2000	The Delta(1)-pyrroline-5-carboxylate synthetase (P5CS; EC not assigned) is the rate-limiting enzyme in proline (Pro) biosynthesis in plants and is subject to feedback inhibition by Pro.	Proline	112-115	delta-1-pyrroline-5-carboxylate synthase-like	Nicotiana tabacum	49-53
10727212-6	2000	FAC1, on the other hand, recognizes a conformational interface that includes the proline/alanine-rich domain of ZF87/MAZ and the first zinc finger.	Proline	81-88	MYC-associated zinc finger protein (purine-binding transcription factor)	Mus musculus	112-120
10725360-7	2000	The proline allele at codon 10 (Pro(10)) was more frequent in blacks compared with whites, and its presence was associated with higher levels of TGF-beta(1) mRNA and protein.	Proline	4-11	transforming growth factor beta 1	Homo sapiens	145-156
10734103-4	2000	CED-6 is composed of a phosphotyrosine-binding (PTB) domain and a proline-rich C-terminal domain with no apparent catalytic domain.	Proline	66-73	GULP PTB domain containing engulfment adaptor 1	Homo sapiens	0-5
10716697-6	2000	Sequence analyses revealed that these two proteins (i) differ only in that a proline residue near the N terminus is hydroxylated in SLR1-BP1 but not in SLR1-BP2, and (ii) are members of the class A pollen coat protein (PCP) family, which includes PCP-A1, an SLG (S locus glycoprotein)-binding protein isolated from Brassica oleracea.	Proline	77-84	S-locus-specific glycoprotein	Brassica oleracea	132-136
10777217-2	2000	A p53 protein lacking the proline-rich region (p53delta62-91) induces many p53-responsive genes but not PIG3.	Proline	26-33	tumor protein p53	Homo sapiens	2-5
10762698-3	2000	Cdk5 and Erk2, proline-directed kinases in neuronal tissues, phosphorylate the Lys-Ser-Pro (KSP) repeats in tail domains of NF-H, NF-M, and other axonal proteins such as tau and synapsin.	Proline	15-22	cyclin-dependent kinase 5	Rattus norvegicus	0-4
10762698-3	2000	Cdk5 and Erk2, proline-directed kinases in neuronal tissues, phosphorylate the Lys-Ser-Pro (KSP) repeats in tail domains of NF-H, NF-M, and other axonal proteins such as tau and synapsin.	Proline	15-22	mitogen activated protein kinase 1	Rattus norvegicus	9-13
10762698-3	2000	Cdk5 and Erk2, proline-directed kinases in neuronal tissues, phosphorylate the Lys-Ser-Pro (KSP) repeats in tail domains of NF-H, NF-M, and other axonal proteins such as tau and synapsin.	Proline	15-22	neurofilament heavy chain	Rattus norvegicus	124-128
10719076-1	2000	The effect of the N-terminal tripeptide of insulin-like growth factor (IGF)-1, glycine-proline-glutamate (GPE), as a neuroprotective agent for nigro-striatal dopaminergic neurons was examined in the present study using a rat model of Parkinson"s disease.	Proline	87-94	insulin-like growth factor 1	Rattus norvegicus	43-77
10708604-5	2000	Among amino acids examined, substitution of Thr at position 485 in CYP3A7 with Pro, which is at the corresponding position of CYP3A4, resulted in an increase in the amount of holo-CYP3A7.	Proline	79-82	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	67-73
10708604-5	2000	Among amino acids examined, substitution of Thr at position 485 in CYP3A7 with Pro, which is at the corresponding position of CYP3A4, resulted in an increase in the amount of holo-CYP3A7.	Proline	79-82	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	180-186
10777217-2	2000	A p53 protein lacking the proline-rich region (p53delta62-91) induces many p53-responsive genes but not PIG3.	Proline	26-33	tumor protein p53	Homo sapiens	47-50
10713104-4	2000	Here we show that the hemopoietic-specific protein HS1 interacted directly with the SH3 domain of Lyn, via its proline-rich region.	Proline	111-118	hematopoietic cell specific Lyn substrate 1	Mus musculus	51-54
10713104-4	2000	Here we show that the hemopoietic-specific protein HS1 interacted directly with the SH3 domain of Lyn, via its proline-rich region.	Proline	111-118	LYN proto-oncogene, Src family tyrosine kinase	Mus musculus	98-101
10777215-3	2000	This 1306-residue protein (mAM, for mouse ATFa-associated Modulator) is rather acidic (pHi 4.5) and contains high proportions of Ser/Thr (21%) and Pro (11%) residues.	Proline	147-150	activating transcription factor 7 interacting protein	Mus musculus	27-30
10777215-3	2000	This 1306-residue protein (mAM, for mouse ATFa-associated Modulator) is rather acidic (pHi 4.5) and contains high proportions of Ser/Thr (21%) and Pro (11%) residues.	Proline	147-150	activating transcription factor 7 interacting protein	Mus musculus	42-67
10777217-0	2000	Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain.	Proline	110-117	tumor protein p53	Homo sapiens	57-60
10777217-4	2000	We show here that the replacement of the N-terminal (amino acids 1-80) or C-terminal (amino acids 344-393) domains of p53 with heterologous domains does not interfere with transcription from the PIG3 promoter, but these chimeras still require the proline-rich region for PIG3 activation.	Proline	247-254	tumor protein p53	Homo sapiens	118-121
10777217-10	2000	Our results suggest that the proline-rich domain of p53 affects the ability of the central domain to bind DNA.	Proline	29-36	tumor protein p53	Homo sapiens	52-55
10777217-11	2000	Moreover, some tumor-derived mutations within the central DNA binding domain of p53 mimic the loss of the proline-rich domain.	Proline	106-113	tumor protein p53	Homo sapiens	80-83
10692392-4	2000	The predominant VRAP mRNA encodes a 389-amino acid protein that contains an SH2 domain and a C-terminal proline-rich motif.	Proline	104-111	SH2 domain containing 2A	Homo sapiens	16-20
10694430-8	2000	Serine 73, which is located in a region rich in proline, glutamic acid, serine, and threonine (PEST), regulates MITF protein stability, since a serine to alanine mutation prevented hUBC9-mediated MITF (S73A) degradation.	Proline	48-55	melanocyte inducing transcription factor	Homo sapiens	112-116
10704338-2	2000	In order to gain deeper insight into the role of the amino-terminal domain of the p24(CA) protein during viral replication, eight highly conserved proline residues known to promote turns and to terminate alpha-helices within the p24 tertiary structure were replaced by a leucine residue (P-position-L).	Proline	147-154	transmembrane p24 trafficking protein 2	Homo sapiens	82-89
10704338-2	2000	In order to gain deeper insight into the role of the amino-terminal domain of the p24(CA) protein during viral replication, eight highly conserved proline residues known to promote turns and to terminate alpha-helices within the p24 tertiary structure were replaced by a leucine residue (P-position-L).	Proline	147-154	transmembrane p24 trafficking protein 2	Homo sapiens	82-85
10702263-2	2000	The membrane proximal region of CD120a (p55) is Ser-, Thr-, and Pro-rich and contains four mitogen-activated protein kinase consensus phosphorylation sites.	Proline	64-67	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	32-38
10702263-2	2000	The membrane proximal region of CD120a (p55) is Ser-, Thr-, and Pro-rich and contains four mitogen-activated protein kinase consensus phosphorylation sites.	Proline	64-67	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	40-43
10675493-7	2000	Sequencing analysis revealed two types of mutations; i) G to C (GCAG to CCAG) transversion type mutation at intron 1-exon 2 splice junction and ii) another C to T transition type mutation resulting in CGA to TGA changing arginine to a termination codon at p16INK4alpha gene codon 80 and the same mutation will alter codon 94 of p19ARF gene from CCG to CTG (proline to leucine).	Proline	357-364	chromogranin A	Homo sapiens	201-204
10759891-2	2000	SAPAP also binds the recently identified proteins, nArgBP2 and synamon (also called Shank 1a), via the proline-rich region and the C-terminus, respectively.	Proline	103-110	sorbin and SH3 domain containing 2	Rattus norvegicus	51-58
10759891-2	2000	SAPAP also binds the recently identified proteins, nArgBP2 and synamon (also called Shank 1a), via the proline-rich region and the C-terminus, respectively.	Proline	103-110	SH3 and multiple ankyrin repeat domains 1	Rattus norvegicus	63-70
10759891-2	2000	SAPAP also binds the recently identified proteins, nArgBP2 and synamon (also called Shank 1a), via the proline-rich region and the C-terminus, respectively.	Proline	103-110	SH3 and multiple ankyrin repeat domains 1	Rattus norvegicus	84-92
10678923-0	2000	Emerging family of proline-specific peptidases of Porphyromonas gingivalis: purification and characterization of serine dipeptidyl peptidase, a structural and functional homologue of mammalian prolyl dipeptidyl peptidase IV.	Proline	19-26	dipeptidyl peptidase 4	Homo sapiens	200-223
10692317-8	2000	Thus, treatments favoring the trans-peptidyl conformation about conserved proline residues in the R domain of CFTR affect openings of CFTR, above and beyond the effect of PKA phosphorylation.	Proline	74-81	CF transmembrane conductance regulator	Homo sapiens	110-114
10692317-8	2000	Thus, treatments favoring the trans-peptidyl conformation about conserved proline residues in the R domain of CFTR affect openings of CFTR, above and beyond the effect of PKA phosphorylation.	Proline	74-81	CF transmembrane conductance regulator	Homo sapiens	134-138
10696108-3	2000	Halpha CGRP(8 - 37) Pro(19) (10(-6) M), with proline at position 19 was an antagonist (apparent pK(B) 6.9+/-0.1).	Proline	20-23	calcitonin-related polypeptide alpha	Rattus norvegicus	7-11
10696108-3	2000	Halpha CGRP(8 - 37) Pro(19) (10(-6) M), with proline at position 19 was an antagonist (apparent pK(B) 6.9+/-0.1).	Proline	45-52	calcitonin-related polypeptide alpha	Rattus norvegicus	7-11
10709996-7	2000	The sites were consistent with the known substrate specificity of cathepsin K, which prefers a hydrophobic residue or proline in the critical P2 position.	Proline	118-125	cathepsin K	Homo sapiens	66-77
10675493-7	2000	Sequencing analysis revealed two types of mutations; i) G to C (GCAG to CCAG) transversion type mutation at intron 1-exon 2 splice junction and ii) another C to T transition type mutation resulting in CGA to TGA changing arginine to a termination codon at p16INK4alpha gene codon 80 and the same mutation will alter codon 94 of p19ARF gene from CCG to CTG (proline to leucine).	Proline	357-364	T-box transcription factor 1	Homo sapiens	208-211
10714828-9	2000	This segment is proline-rich but contains smaller stretches of polyproline and is 30 amino acids shorter than the comparable segment of mouse GAPDS.	Proline	16-23	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Mus musculus	142-147
10689174-2	2000	When cultured in liquid minimal medium, the proline-nonutilizing mutant containing the put1 mutation (proline oxidase-deficient) produced more intracellular proline, and increased the cell survival rate as compared to the wild-type strain after freezing and desiccation.	Proline	44-51	proline dehydrogenase	Saccharomyces cerevisiae S288C	87-91
10689174-2	2000	When cultured in liquid minimal medium, the proline-nonutilizing mutant containing the put1 mutation (proline oxidase-deficient) produced more intracellular proline, and increased the cell survival rate as compared to the wild-type strain after freezing and desiccation.	Proline	102-109	proline dehydrogenase	Saccharomyces cerevisiae S288C	87-91
10689174-4	2000	PUT1-disrupted mutants in minimal medium supplemented with external proline at 0.1% accumulated higher proline levels than those of the control strains (17-22-fold).	Proline	68-75	proline dehydrogenase	Saccharomyces cerevisiae S288C	0-4
10689174-4	2000	PUT1-disrupted mutants in minimal medium supplemented with external proline at 0.1% accumulated higher proline levels than those of the control strains (17-22-fold).	Proline	103-110	proline dehydrogenase	Saccharomyces cerevisiae S288C	0-4
12770239-6	2000	During such periods, beetles used proline exclusively as fuel for flight as evidenced by the increase in the level of alanine in the haemolymph and decrease of the level of proline; the concentrations of carbohydrates and lipids remained unchanged.Activities of malic enzyme and alanine aminotransferase (enzymes involved in transamination in proline metabolism), glyceraldehyde-3-phosphate dehydrogenase (enzyme of glycolysis), 3-hydroxyacyl-CoA dehydrogenase (enzyme of beta-oxidation of fatty acids) and of malate dehydrogenase (enzyme of Krebs cycle) were measured in fat body and flight muscles.	Proline	34-41	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	364-404
12770239-6	2000	During such periods, beetles used proline exclusively as fuel for flight as evidenced by the increase in the level of alanine in the haemolymph and decrease of the level of proline; the concentrations of carbohydrates and lipids remained unchanged.Activities of malic enzyme and alanine aminotransferase (enzymes involved in transamination in proline metabolism), glyceraldehyde-3-phosphate dehydrogenase (enzyme of glycolysis), 3-hydroxyacyl-CoA dehydrogenase (enzyme of beta-oxidation of fatty acids) and of malate dehydrogenase (enzyme of Krebs cycle) were measured in fat body and flight muscles.	Proline	34-41	malic enzyme 1	Homo sapiens	510-530
10750555-2	2000	A T--&gt;C polymorphism in exon 1 of the TGF-beta1 gene, which results in the substitution of proline for leucine, is associated with bone mineral density (BMD).	Proline	94-101	transforming growth factor beta 1	Homo sapiens	41-50
10805132-3	2000	Two such systems that we are currently studying include an SH2 domain from the protein Crk with a region containing 9 prolines in a 14 amino acid sequence, as well as a WW domain that interacts with a proline-rich target.	Proline	118-126	CRK proto-oncogene, adaptor protein	Homo sapiens	87-90
10805132-3	2000	Two such systems that we are currently studying include an SH2 domain from the protein Crk with a region containing 9 prolines in a 14 amino acid sequence, as well as a WW domain that interacts with a proline-rich target.	Proline	118-125	CRK proto-oncogene, adaptor protein	Homo sapiens	87-90
10752617-8	2000	For the equilibrium-denatured scFv fragment, whose native structure formation is dependent on a cis conformation of an interface proline in V(L), this cis/trans isomerization reaction proceeds about one order in magnitude more slowly than the escape from the trap to a conformation where full H/D exchange protection is already achieved.	Proline	129-136	immunglobulin heavy chain variable region	Homo sapiens	30-34
10669729-6	2000	In CstF-77, a proline-rich domain is necessary not only for binding both other subunits but also for self-association, an interaction consistent with genetic studies in Drosophila.	Proline	14-21	suppressor of forked	Drosophila melanogaster	3-10
10669742-4	2000	CIZ consists of the following: a putative leucine zipper; a serine/threonine-rich region; a proline-rich sequence; five, six, or eight Kruppel-type C(2)H(2) zinc fingers; and the glutamine-alanine repeat.	Proline	92-99	zinc finger protein 384	Homo sapiens	0-3
10778757-3	2000	Sequence analysis of Incw2 clones derived from the parental Mn1 and the mutant genotypes shows a C to T transition in the mn1-89 allele, leading to a single amino acid alteration (proline to leucine) near the C-terminus of the mutant INCW2 protein.	Proline	180-187	miniature seed 1	Zea mays	21-26
10778757-3	2000	Sequence analysis of Incw2 clones derived from the parental Mn1 and the mutant genotypes shows a C to T transition in the mn1-89 allele, leading to a single amino acid alteration (proline to leucine) near the C-terminus of the mutant INCW2 protein.	Proline	180-187	miniature seed 1	Zea mays	60-63
10778757-3	2000	Sequence analysis of Incw2 clones derived from the parental Mn1 and the mutant genotypes shows a C to T transition in the mn1-89 allele, leading to a single amino acid alteration (proline to leucine) near the C-terminus of the mutant INCW2 protein.	Proline	180-187	miniature seed 1	Zea mays	122-125
10712533-0	2000	Expression of AtPRP3, a proline-rich structural cell wall protein from Arabidopsis, is regulated by cell-type-specific developmental pathways involved in root hair formation.	Proline	24-31	proline-rich protein 3	Arabidopsis thaliana	14-20
10712533-2	2000	We demonstrate that AtPRP3, a proline-rich cell wall protein in Arabidopsis, is expressed in root-hair-bearing epidermal cells at the root/shoot junction and within the root differentiation zone of light-grown seedlings.	Proline	30-37	proline-rich protein 3	Arabidopsis thaliana	20-26
10752624-4	2000	The increase is modest (threefold) for substrates specific for tPA that carry Pro or Gly at P2, but reaches 80-fold for less specific substrates carrying Arg at P2.	Proline	78-81	chromosome 20 open reading frame 181	Homo sapiens	63-66
10701757-1	2000	Proline-specific dipeptidyl peptidase (DPP IV) is an established enzyme known to degrade neuropeptides and peptide hormones in vertebrate tissues.	Proline	0-7	dipeptidyl peptidase 4	Homo sapiens	39-45
10684658-3	2000	Investigation of a set of small peptides revealed that, as with protein substrates, p38-alpha behaves as a proline-directed Ser/Thr MAP kinase for a peptide substrate, peptide 4 (IPTSPITTTYFFFKKK).	Proline	107-114	mitogen-activated protein kinase 14	Homo sapiens	84-93
10683340-5	2000	The amino-terminal domain of LMP2A includes multiple proline-rich regions, which may provide binding sites for proteins containing SH3 or WW domains.	Proline	53-60	LMP2A	Human gammaherpesvirus 4	29-34
10699464-3	2000	The C-terminal domain of hSLK includes both the coiled-coil structure and four Pro/Glu/Ser/Thr-rich (PEST) sequences, but not the GTPase-binding domain (GBD) that is characteristic of the p21-activated kinase (PAK) family, polyproline consensus binding sites, or the Leu-rich domain seen in the group I germinal center kinases (GCKs).	Proline	79-82	STE20 like kinase	Homo sapiens	25-29
10671506-7	2000	Remarkably, aspirin-treated COX-2 formed 15R-HETE with removal of the pro-S hydrogen at C-13 (3-9% retention of pro-S tritium label), the same stereoselectivity as in the formation of prostaglandins by native cyclooxygenase.	Proline	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
10671506-7	2000	Remarkably, aspirin-treated COX-2 formed 15R-HETE with removal of the pro-S hydrogen at C-13 (3-9% retention of pro-S tritium label), the same stereoselectivity as in the formation of prostaglandins by native cyclooxygenase.	Proline	70-75	homeobox C13	Homo sapiens	88-92
10671525-3	2000	The results reveal that residues Ser-4, Leu-5, Pro-6, Pro-7, Ala-9, and Leu-10 endow CTx PnIB with affinity for alpha(7)/5-hydroxytryptamine-3 receptors; side chains of these residues cluster in a localized region within the three-dimensional structure of CTx PnIB.	Proline	47-50	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	85-88
10680816-2	2000	Sequencing of the p53 gene, exon 4, showed heterozygosity (Arg-Pro) at codon 72 in five of six PML patients.	Proline	63-66	tumor protein p53	Homo sapiens	18-21
10671525-3	2000	The results reveal that residues Ser-4, Leu-5, Pro-6, Pro-7, Ala-9, and Leu-10 endow CTx PnIB with affinity for alpha(7)/5-hydroxytryptamine-3 receptors; side chains of these residues cluster in a localized region within the three-dimensional structure of CTx PnIB.	Proline	47-50	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	256-259
10671525-3	2000	The results reveal that residues Ser-4, Leu-5, Pro-6, Pro-7, Ala-9, and Leu-10 endow CTx PnIB with affinity for alpha(7)/5-hydroxytryptamine-3 receptors; side chains of these residues cluster in a localized region within the three-dimensional structure of CTx PnIB.	Proline	54-57	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	85-88
10671525-8	2000	We also find weaker interactions between Pro-6 of CTx PnIB and Trp-149 and between both Pro-6 and Pro-7 and Tyr-93 of alpha(7).	Proline	41-44	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	50-53
10660579-9	2000	The herein described mechanism of SH3 selection by Nef via a "pocket" proximal to the canonical proline-rich motif may be a common feature for SH3 recognition by their natural ligands.	Proline	96-103	S100 calcium binding protein B	Homo sapiens	51-54
10671570-3	2000	A fusion protein containing the SH3 domains of the adaptor protein Nck interacted strongly with the R-Ras proline-rich sequence and with the intact protein.	Proline	106-113	non-catalytic region of tyrosine kinase adaptor protein 1	Mus musculus	67-70
10671570-5	2000	The Nck binding, which was mediated by the second of the three SH3 domains of Nck, was obliterated by mutations in the proline-rich sequence of R-Ras.	Proline	119-126	non-catalytic region of tyrosine kinase adaptor protein 1	Mus musculus	4-7
10671570-5	2000	The Nck binding, which was mediated by the second of the three SH3 domains of Nck, was obliterated by mutations in the proline-rich sequence of R-Ras.	Proline	119-126	non-catalytic region of tyrosine kinase adaptor protein 1	Mus musculus	78-81
10660538-4	2000	Contrary to bax, another known pro-apoptotic p53-target gene, both mouse and human FAS p53REs are still activated by the discriminatory p53 mutants Pro-175 and Ala-143, a class of mutants unable to induce apoptosis.	Proline	148-151	tumor protein p53	Homo sapiens	87-90
10660538-4	2000	Contrary to bax, another known pro-apoptotic p53-target gene, both mouse and human FAS p53REs are still activated by the discriminatory p53 mutants Pro-175 and Ala-143, a class of mutants unable to induce apoptosis.	Proline	148-151	tumor protein p53	Homo sapiens	87-90
10665486-1	2000	The end-plate species of acetylcholinesterase (AChE) is an asymmetric enzyme consisting of a collagenic tail subunit composed of three collagenic strands (ColQ), each attached to a tetramer of the T isoform of the catalytic subunit (AChE(T)) via a proline-rich attachment domain.	Proline	248-255	acetylcholinesterase (Cartwright blood group)	Homo sapiens	25-45
10665486-1	2000	The end-plate species of acetylcholinesterase (AChE) is an asymmetric enzyme consisting of a collagenic tail subunit composed of three collagenic strands (ColQ), each attached to a tetramer of the T isoform of the catalytic subunit (AChE(T)) via a proline-rich attachment domain.	Proline	248-255	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-51
10648423-5	2000	The AF3p21 gene encodes a protein of 722 amino acids, which contains an Src homology 3 (SH3) domain, a proline-rich domain, and a bipartite nuclear localizing signal (NLS).	Proline	103-110	NCK interacting protein with SH3 domain	Homo sapiens	4-10
10639328-2	2000	The carboxy-terminal domains of NF-M and NF-H form side-arms that project from the filament and that of NF-H contains multiple repeats of the motif lys-ser-pro, the serines of which are targets for phosphorylation.	Proline	66-69	neurofilament medium chain	Homo sapiens	32-36
10791892-0	2000	Ser787 in the proline-rich region of human MAP4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization.	Proline	14-21	microtubule associated protein 4	Homo sapiens	43-47
10651816-0	2000	Membrane fusion by proline-rich Rz1 lipoprotein, the bacteriophage lambda Rz1 gene product.	Proline	19-26	prolysis lipoprotein RzoD	Escherichia virus Lambda	32-35
10651816-0	2000	Membrane fusion by proline-rich Rz1 lipoprotein, the bacteriophage lambda Rz1 gene product.	Proline	19-26	prolysis lipoprotein RzoD	Escherichia virus Lambda	74-77
10651816-6	2000	This might mean that the proline stretch of Rz1 allowed interaction with membrane lipids.	Proline	25-32	prolysis lipoprotein RzoD	Escherichia virus Lambda	44-47
10639328-2	2000	The carboxy-terminal domains of NF-M and NF-H form side-arms that project from the filament and that of NF-H contains multiple repeats of the motif lys-ser-pro, the serines of which are targets for phosphorylation.	Proline	66-69	neurofilament heavy chain	Homo sapiens	41-45
10646540-9	2000	Both K-variant and wild-type BChE assembled into tetramers in the presence of poly-L-proline or the proline-rich attachment domain of the collagen tail.	Proline	85-92	cholinesterase	Cricetulus griseus	29-33
10719811-1	2000	A common polymorphism of the wild type p53 is known at codon 72 of exon 4, with 2 alleles encoding either arginine (CGC, p53Arg) or proline (CCC, p53Pro).	Proline	132-139	tumor protein p53	Homo sapiens	39-42
10644338-5	2000	In this study, we made and analyzed 12 Env proteins with substitutions for the central proline of the fusion peptide.	Proline	87-94	endogenous retrovirus group K member 6, envelope	Homo sapiens	39-42
10854035-11	2000	This divergent region also included a proline deletion in the cat trkC sequence.	Proline	38-45	neurotrophic receptor tyrosine kinase 3	Homo sapiens	66-70
10644338-9	2000	(ii) Surprisingly, the proline is required for maximal processing of the Env precursor into its surface and TM subunits; the amount of processing correlates linearly with the propensity of the substituted residue to be found in a reverse turn.	Proline	23-30	endogenous retrovirus group K member 6, envelope	Homo sapiens	73-76
10644338-14	2000	Our findings suggest that the central proline in the ASLV fusion peptide is important for the formation of the native (metastable) Env structure as well as for membrane interactions that lead to fusion.	Proline	38-45	endogenous retrovirus group K member 6, envelope	Homo sapiens	131-134
10629046-1	2000	The proline utilization pathway in Saccharomyces cerevisiae is regulated by the Put3p transcriptional activator in response to the presence of the inducer proline and the quality of the nitrogen source in the growth medium.	Proline	4-11	Put3p	Saccharomyces cerevisiae S288C	80-85
10629046-1	2000	The proline utilization pathway in Saccharomyces cerevisiae is regulated by the Put3p transcriptional activator in response to the presence of the inducer proline and the quality of the nitrogen source in the growth medium.	Proline	155-162	Put3p	Saccharomyces cerevisiae S288C	80-85
10629046-2	2000	Put3p is constitutively bound to the promoters of its target genes, PUT1 and PUT2, under all conditions studied but activates transcription to the maximum extent only in the absence of rich nitrogen sources and in the presence of proline (i.e., when proline serves as the sole source of nitrogen).	Proline	230-237	Put3p	Saccharomyces cerevisiae S288C	0-5
10629046-2	2000	Put3p is constitutively bound to the promoters of its target genes, PUT1 and PUT2, under all conditions studied but activates transcription to the maximum extent only in the absence of rich nitrogen sources and in the presence of proline (i.e., when proline serves as the sole source of nitrogen).	Proline	230-237	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	77-81
10629046-2	2000	Put3p is constitutively bound to the promoters of its target genes, PUT1 and PUT2, under all conditions studied but activates transcription to the maximum extent only in the absence of rich nitrogen sources and in the presence of proline (i.e., when proline serves as the sole source of nitrogen).	Proline	250-257	Put3p	Saccharomyces cerevisiae S288C	0-5
10629046-10	2000	These results demonstrate a correlation between the phosphorylation status of Put3p and its ability to activate its target genes and suggest that there are two signals, proline induction and quality of nitrogen source, impinging on Put3p that act synergistically for maximum expression of the proline utilization pathway.	Proline	169-176	Put3p	Saccharomyces cerevisiae S288C	78-83
10629046-10	2000	These results demonstrate a correlation between the phosphorylation status of Put3p and its ability to activate its target genes and suggest that there are two signals, proline induction and quality of nitrogen source, impinging on Put3p that act synergistically for maximum expression of the proline utilization pathway.	Proline	169-176	Put3p	Saccharomyces cerevisiae S288C	232-237
10629046-10	2000	These results demonstrate a correlation between the phosphorylation status of Put3p and its ability to activate its target genes and suggest that there are two signals, proline induction and quality of nitrogen source, impinging on Put3p that act synergistically for maximum expression of the proline utilization pathway.	Proline	293-300	Put3p	Saccharomyces cerevisiae S288C	78-83
10629046-10	2000	These results demonstrate a correlation between the phosphorylation status of Put3p and its ability to activate its target genes and suggest that there are two signals, proline induction and quality of nitrogen source, impinging on Put3p that act synergistically for maximum expression of the proline utilization pathway.	Proline	293-300	Put3p	Saccharomyces cerevisiae S288C	232-237
10716186-8	2000	Formation of higher-order aggregates is believed to be crucial for proline to function as a protein folding aid.	Proline	67-74	activation induced cytidine deaminase	Homo sapiens	108-111
10636929-5	2000	Second, the Itk proline-rich region binds to Grb2 and LAT.	Proline	16-23	IL2 inducible T cell kinase	Homo sapiens	12-15
10642173-2	2000	Previous studies have shown that the SH3 domains of Hck and Lyn bind to Nef via proline-rich sequences in vitro, identifying these Src-related kinases as potential targets for Nef in vivo.	Proline	80-87	HCK proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	52-55
10642173-2	2000	Previous studies have shown that the SH3 domains of Hck and Lyn bind to Nef via proline-rich sequences in vitro, identifying these Src-related kinases as potential targets for Nef in vivo.	Proline	80-87	LYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	60-63
10642173-2	2000	Previous studies have shown that the SH3 domains of Hck and Lyn bind to Nef via proline-rich sequences in vitro, identifying these Src-related kinases as potential targets for Nef in vivo.	Proline	80-87	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	131-134
10716195-2	2000	In particular, the cis proline peptide conformation at Tyr92-Pro93 of bovine pancreatic ribonuclease A (RNase A) has been proposed to be crucial for chain folding initiation.	Proline	23-30	ribonuclease pancreatic	Bos taurus	88-102
10716195-2	2000	In particular, the cis proline peptide conformation at Tyr92-Pro93 of bovine pancreatic ribonuclease A (RNase A) has been proposed to be crucial for chain folding initiation.	Proline	23-30	ribonuclease pancreatic	Bos taurus	104-111
10716195-6	2000	While a glycine residue at position 93 accommodates a type-II bend (with a positive value of phi93), RNase A molecules with either proline or alanine residues at this position appear to require a cis peptide group with a type-VI beta-bend for proper folding.	Proline	131-138	ribonuclease pancreatic	Bos taurus	101-108
10644696-5	2000	Evaluation of the phosphate incorporation into these peptides identified DYRK1A as a proline-directed kinase with a phosphorylation consensus sequence (RPX(S/T)P) similar to that of ERK2 (PX(S/T)P).	Proline	85-92	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	73-79
10636915-3	2000	This activation requires the proline-rich box 1 region of the GH receptor required for JAK2 association and is prevented by pretreatment of cells with the JAK2-specific inhibitor AG490.	Proline	29-36	growth hormone receptor	Homo sapiens	62-73
10636929-5	2000	Second, the Itk proline-rich region binds to Grb2 and LAT.	Proline	16-23	growth factor receptor bound protein 2	Homo sapiens	45-49
10636915-3	2000	This activation requires the proline-rich box 1 region of the GH receptor required for JAK2 association and is prevented by pretreatment of cells with the JAK2-specific inhibitor AG490.	Proline	29-36	Janus kinase 2	Homo sapiens	87-91
10636915-3	2000	This activation requires the proline-rich box 1 region of the GH receptor required for JAK2 association and is prevented by pretreatment of cells with the JAK2-specific inhibitor AG490.	Proline	29-36	Janus kinase 2	Homo sapiens	155-159
10636929-5	2000	Second, the Itk proline-rich region binds to Grb2 and LAT.	Proline	16-23	linker for activation of T cells	Homo sapiens	54-57
10636916-0	2000	The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.	Proline	39-46	SMAD family member 4	Homo sapiens	4-9
10625663-3	2000	SNIP is a hydrophilic, 145-kDa protein that comprises two predicted coiled-coil domains, two highly charged regions, and two proline-rich domains with multiple PPXY and PXXP motifs.	Proline	125-132	SRC kinase signaling inhibitor 1	Rattus norvegicus	0-4
10636916-0	2000	The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.	Proline	39-46	E1A binding protein p300	Homo sapiens	53-57
10636916-3	2000	We previously identified a 48-amino acid proline-rich regulatory element within the middle linker domain of this molecule, the Smad4 activation domain (SAD), which is essential for mediating these signaling activities.	Proline	41-48	SMAD family member 4	Homo sapiens	127-132
10636916-6	2000	Furthermore, the SAD itself is able to activate transcription in heterologous reporter assays, identifying it as a proline-rich transcriptional activation domain, and indicating that the SAD is both necessary and sufficient to activate Smad-dependent transcriptional responses.	Proline	115-122	SMAD family member 4	Homo sapiens	236-240
10631010-5	2000	The 24k-endopeptidase specifically hydrolyzed the Ser(441)-Val(442) peptide bond in human plasmin(ogen), with additional cleavage of the Lys(78)-Val(79) and Pro(447)-Val(448) peptide bonds, and a secondary cleavage at Lys(615)-Val(616).	Proline	157-160	plasminogen	Homo sapiens	90-97
10631288-4	2000	Helix 6 is one of the transmembrane helices of rhodopsin that contains a proline (amino acid residue 267) and the influence of this proline on the structure of this transmembrane domain was unknown.	Proline	73-80	rhodopsin	Homo sapiens	47-56
10631288-4	2000	Helix 6 is one of the transmembrane helices of rhodopsin that contains a proline (amino acid residue 267) and the influence of this proline on the structure of this transmembrane domain was unknown.	Proline	132-139	rhodopsin	Homo sapiens	47-56
10620503-9	2000	Taken together, these results suggest that osmotic stress activates at least two tau-directed protein kinases, one proline-directed and one non-proline-directed, that SAPK3 can phosphorylate tau on Ser/Thr-Pro residues in situ, and that Ser-262/356 phosphorylation only partially regulates tau localization in the cell.	Proline	115-122	mitogen-activated protein kinase 12	Homo sapiens	167-172
10620503-9	2000	Taken together, these results suggest that osmotic stress activates at least two tau-directed protein kinases, one proline-directed and one non-proline-directed, that SAPK3 can phosphorylate tau on Ser/Thr-Pro residues in situ, and that Ser-262/356 phosphorylation only partially regulates tau localization in the cell.	Proline	144-151	mitogen-activated protein kinase 12	Homo sapiens	167-172
10620503-9	2000	Taken together, these results suggest that osmotic stress activates at least two tau-directed protein kinases, one proline-directed and one non-proline-directed, that SAPK3 can phosphorylate tau on Ser/Thr-Pro residues in situ, and that Ser-262/356 phosphorylation only partially regulates tau localization in the cell.	Proline	206-209	mitogen-activated protein kinase 12	Homo sapiens	167-172
10606651-6	2000	Alignment of CstF-64 homologues shows that the proteins have a conserved N-terminal 200 amino acids, the first half of which is the RNA binding domain with the second half likely to contain the CstF-77 interaction domain; a central region variable in length and rich in glycine, proline and glutamine residues and containing an unusual degenerate repeat motif; and then a conserved C-terminal 50 amino acids.	Proline	279-286	Cleavage stimulation factor 64 kD subunit	Drosophila melanogaster	13-20
10606657-0	2000	The dhfr oribeta-binding protein RIP60 contains 15 zinc fingers: DNA binding and looping by the central three fingers and an associated proline-rich region.	Proline	136-143	replication initiator 1	Homo sapiens	33-38
11996107-1	2000	A polymorphism at codon 72 of gene p53 results in the presence of either arginine or proline at this position.	Proline	85-92	tumor protein p53	Homo sapiens	35-38
10600634-2	2000	The PRL/growth hormone/cytokine receptor family conserves a proline-rich sequence in the cytoplasmic juxtamembrane region (Box 1) required for association and subsequent activation of Jaks.	Proline	60-67	Janus kinase 2	Rattus norvegicus	184-188
11082759-1	2000	Mucin is a large glycoprotein (M up to 4-6.10(6)) with a high content of serine, threonine, and proline residues and numerous O-linked saccharides, often occurring in clusters on the polypeptide.	Proline	96-103	LOC100508689	Homo sapiens	0-5
10651894-3	2000	FMR2 encodes a large protein of 1311 amino acids and is a member of a gene family encoding proline-serine-rich proteins that have properties of nuclear transcription factors.	Proline	91-98	fragile site, folic acid type, rare, fra(X)(q28) E	Homo sapiens	0-4
10620310-2	2000	We report herein in situ tapping mode atomic force microscopy (TMAFM) studies of crystalline neutral protamine Lys(B28)Pro(B29) (NPL), a complex of Lys(B28)Pro(B29) insulin, in which the C-terminal prolyl and lysyl residues of human insulin are inverted, and protamine that is used as an intermediate time-action therapy for treating insulin-dependent diabetes.	Proline	119-122	MIS18 kinetochore protein A	Homo sapiens	111-118
10620310-2	2000	We report herein in situ tapping mode atomic force microscopy (TMAFM) studies of crystalline neutral protamine Lys(B28)Pro(B29) (NPL), a complex of Lys(B28)Pro(B29) insulin, in which the C-terminal prolyl and lysyl residues of human insulin are inverted, and protamine that is used as an intermediate time-action therapy for treating insulin-dependent diabetes.	Proline	119-122	N-acetylneuraminate pyruvate lyase	Homo sapiens	129-132
10620310-2	2000	We report herein in situ tapping mode atomic force microscopy (TMAFM) studies of crystalline neutral protamine Lys(B28)Pro(B29) (NPL), a complex of Lys(B28)Pro(B29) insulin, in which the C-terminal prolyl and lysyl residues of human insulin are inverted, and protamine that is used as an intermediate time-action therapy for treating insulin-dependent diabetes.	Proline	119-122	MIS18 kinetochore protein A	Homo sapiens	148-155
10620310-2	2000	We report herein in situ tapping mode atomic force microscopy (TMAFM) studies of crystalline neutral protamine Lys(B28)Pro(B29) (NPL), a complex of Lys(B28)Pro(B29) insulin, in which the C-terminal prolyl and lysyl residues of human insulin are inverted, and protamine that is used as an intermediate time-action therapy for treating insulin-dependent diabetes.	Proline	156-159	MIS18 kinetochore protein A	Homo sapiens	111-118
10620310-2	2000	We report herein in situ tapping mode atomic force microscopy (TMAFM) studies of crystalline neutral protamine Lys(B28)Pro(B29) (NPL), a complex of Lys(B28)Pro(B29) insulin, in which the C-terminal prolyl and lysyl residues of human insulin are inverted, and protamine that is used as an intermediate time-action therapy for treating insulin-dependent diabetes.	Proline	156-159	N-acetylneuraminate pyruvate lyase	Homo sapiens	129-132
10620310-2	2000	We report herein in situ tapping mode atomic force microscopy (TMAFM) studies of crystalline neutral protamine Lys(B28)Pro(B29) (NPL), a complex of Lys(B28)Pro(B29) insulin, in which the C-terminal prolyl and lysyl residues of human insulin are inverted, and protamine that is used as an intermediate time-action therapy for treating insulin-dependent diabetes.	Proline	156-159	MIS18 kinetochore protein A	Homo sapiens	148-155
11255560-1	2000	Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes.	Proline	89-92	gonadotropin releasing hormone 1	Homo sapiens	0-30
11255560-1	2000	Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes.	Proline	89-92	gonadotropin releasing hormone 1	Homo sapiens	32-36
10600634-2	2000	The PRL/growth hormone/cytokine receptor family conserves a proline-rich sequence in the cytoplasmic juxtamembrane region (Box 1) required for association and subsequent activation of Jaks.	Proline	60-67	prolactin	Rattus norvegicus	4-7
10600634-2	2000	The PRL/growth hormone/cytokine receptor family conserves a proline-rich sequence in the cytoplasmic juxtamembrane region (Box 1) required for association and subsequent activation of Jaks.	Proline	60-67	gonadotropin releasing hormone receptor	Rattus norvegicus	8-22
11467771-2	2000	DPPIV has numerous functions including involvement in T-cell activation, cell adhesion, digestion of proline containing peptides in the kidney and intestines, HIV infection and apoptosis, and regulation of tumorigenicity in certain melanoma cells.	Proline	101-108	dipeptidyl peptidase 4	Homo sapiens	0-5
10795627-3	2000	The predicted amino acid structure for paxillin shows at the amino-terminus five LD motifs, a proline-rich domain, several potential phosphorylation sites and four carboxy-terminal LIM domains.	Proline	94-101	paxillin	Homo sapiens	39-47
11202225-7	2000	The resultant IGF-I protein appears to have a dual role, first as an endogenous neurotropic and anti-apoptotic agent acting directly on stressed cells, and second as a prohormone for generation of the N-terminal tripeptide of IGF-I, glycine-proline-glutamate (GPE), and the resulting des-N-(1-3)-IGF-I, both of which have specific neuroprotective properties.	Proline	241-248	insulin-like growth factor 1	Rattus norvegicus	14-19
11140379-2	2000	The N-terminus of the cytoplasmic WAS protein (WASP) has similarity to WH1 domains, which recognize proline-rich sequences and direct protein localization and formation of multicomponent assemblies.	Proline	100-107	WASP actin nucleation promoting factor	Homo sapiens	34-45
11140379-2	2000	The N-terminus of the cytoplasmic WAS protein (WASP) has similarity to WH1 domains, which recognize proline-rich sequences and direct protein localization and formation of multicomponent assemblies.	Proline	100-107	WASP actin nucleation promoting factor	Homo sapiens	47-51
10926322-0	2000	Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes.	Proline	13-20	neuropeptide Y	Homo sapiens	43-57
10737978-7	2000	One patient (P2) had a PAX6 protein with de novo in-frame deletion of alanine, arginine, and proline at codon positions 37, 38, and 39.	Proline	93-100	paired box 6	Homo sapiens	23-27
11202225-7	2000	The resultant IGF-I protein appears to have a dual role, first as an endogenous neurotropic and anti-apoptotic agent acting directly on stressed cells, and second as a prohormone for generation of the N-terminal tripeptide of IGF-I, glycine-proline-glutamate (GPE), and the resulting des-N-(1-3)-IGF-I, both of which have specific neuroprotective properties.	Proline	241-248	insulin-like growth factor 1	Rattus norvegicus	226-231
11202225-7	2000	The resultant IGF-I protein appears to have a dual role, first as an endogenous neurotropic and anti-apoptotic agent acting directly on stressed cells, and second as a prohormone for generation of the N-terminal tripeptide of IGF-I, glycine-proline-glutamate (GPE), and the resulting des-N-(1-3)-IGF-I, both of which have specific neuroprotective properties.	Proline	241-248	insulin-like growth factor 1	Rattus norvegicus	226-231
10607764-0	2000	Humoral immunity against the proline-rich peptide epitope of the IgA1 hinge region in IgA nephropathy.	Proline	29-36	immunoglobulin heavy constant alpha 1	Homo sapiens	65-69
10611245-3	2000	In addition, the ESX1 protein contains several notable features that are not often associated with homeoproteins, including an atypical homeodomain of the paired-like class, a proline-rich region that contains an SH3 binding motif, and a novel repeat region consisting of prolines alternating with phenylalanines or asparagines that we term the PF/PN motif.	Proline	176-183	ESX homeobox 1	Homo sapiens	17-21
10611245-3	2000	In addition, the ESX1 protein contains several notable features that are not often associated with homeoproteins, including an atypical homeodomain of the paired-like class, a proline-rich region that contains an SH3 binding motif, and a novel repeat region consisting of prolines alternating with phenylalanines or asparagines that we term the PF/PN motif.	Proline	272-280	ESX homeobox 1	Homo sapiens	17-21
10611245-6	2000	Finally, we show that the proline-rich region of ESX1 mediates interactions in vitro with the c-abl SH3 domain as well as with certain WW domains.	Proline	26-33	ESX homeobox 1	Homo sapiens	49-53
10611245-6	2000	Finally, we show that the proline-rich region of ESX1 mediates interactions in vitro with the c-abl SH3 domain as well as with certain WW domains.	Proline	26-33	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	94-99
10607764-0	2000	Humoral immunity against the proline-rich peptide epitope of the IgA1 hinge region in IgA nephropathy.	Proline	29-36	IGAN1	Homo sapiens	86-101
11200979-6	2000	A subgroup of patients with familial orthostatic intolerance differ from inbound space travelers in that they have an alanine-to-to-proline mutation at amino acid position 457 in their norepinephrine transporter gene.	Proline	132-139	solute carrier family 6 member 2	Homo sapiens	185-211
11113337-0	2000	Microtubule-associated protein-2 located in growth regions of rat hippocampal neurons is highly phosphorylated at its proline-rich region.	Proline	118-125	microtubule-associated protein 2	Rattus norvegicus	0-32
11113337-13	2000	From these results we suggest that the phosphorylation of MAP2 at its proline-rich region is an important event during neuritogenesis.	Proline	70-77	microtubule-associated protein 2	Rattus norvegicus	58-62
10600384-8	1999	In contrast to serine 29 of profilin I, tyrosine 29 in profilin II is capable of forming an additional stacking interaction and a hydrogen bond with poly-L-proline which may account for the increased affinity of the second isoform for proline-rich peptides.	Proline	156-163	profilin 1	Homo sapiens	28-51
10668804-4	2000	SRm300 also contains a novel and highly conserved N-terminal domain, several unique repeated motifs rich in S, R, and proline residues, and two very long polyserine tracts.	Proline	118-125	serine/arginine repetitive matrix 2	Homo sapiens	0-6
11853584-8	2000	The alteration in the DNA sequence was identified as a heterozygous transversional change of C to T at the second nucleotide in codon 216 of RDS gene, resulting in the amino acid replacement of proline residue with leucine residue (Pro216Leu).	Proline	194-201	peripherin 2	Homo sapiens	141-144
10608857-8	1999	Using the yeast two-hybrid system we show that profilins bind to SMN and that this binding depends on its proline-rich motifs.	Proline	106-113	survival of motor neuron 1, telomeric	Homo sapiens	65-68
10593981-4	1999	Each B-Myb phosphorylation site contained a phosphoserine or phosphothreonine followed by a proline, suggesting that this phosphorylation is due to a proline-directed kinase.	Proline	92-99	MYB proto-oncogene like 2	Homo sapiens	5-10
10740817-3	2000	Pin1 is a phosphorylation-dependent prolyl isomerase that specifically isomerizes the phosphorylated serine/threonine-proline bond.	Proline	118-125	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
11147357-3	2000	Since yeast proline auxotroph will not survive in rich medium (YPD), YPD could be used as a selection pressure, and pCBy314 could be maintained mitotically stable in transformants of yeast Pro3- auxotroph (MB299-7A) in rich medium.	Proline	12-19	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	189-193
10593949-0	1999	Association of two nuclear proteins, Npw38 and NpwBP, via the interaction between the WW domain and a novel proline-rich motif containing glycine and arginine.	Proline	108-115	polyglutamine binding protein 1	Homo sapiens	37-42
10593949-0	1999	Association of two nuclear proteins, Npw38 and NpwBP, via the interaction between the WW domain and a novel proline-rich motif containing glycine and arginine.	Proline	108-115	WW domain binding protein 11	Homo sapiens	47-52
10600384-8	1999	In contrast to serine 29 of profilin I, tyrosine 29 in profilin II is capable of forming an additional stacking interaction and a hydrogen bond with poly-L-proline which may account for the increased affinity of the second isoform for proline-rich peptides.	Proline	156-163	profilin 2	Homo sapiens	55-66
10593949-4	1999	NpwBP contains two proline-rich regions that are capable of binding to the WW domain of Npw38.	Proline	19-26	WW domain binding protein 11	Homo sapiens	0-5
10593949-4	1999	NpwBP contains two proline-rich regions that are capable of binding to the WW domain of Npw38.	Proline	19-26	polyglutamine binding protein 1	Homo sapiens	88-93
10602705-4	1999	The optimization of these structural parameters led to the synthesis of nanomolar and subnanomolar inhibitors of aminopeptidase A such as H(3)N(+)CH(CH(2)CH(2)SO(3)(-))CH(SH)CO-Ile-(3-COOH)Pro that exhibits a K(i) of 0.87 nM.	Proline	189-192	glutamyl aminopeptidase	Homo sapiens	113-129
10593949-5	1999	The binding analysis using an oligopeptide-immobilized membrane revealed that the WW domain of Npw38 preferentially recognizes a short proline-rich sequence, PPGPPP, surrounded by an arginine residue, so we named it a PGR motif.	Proline	135-142	polyglutamine binding protein 1	Homo sapiens	95-100
10618717-5	1999	Full-length DDA3 cDNA was cloned and it contained an open reading frame predicted to encode a proline rich protein of 329 amino acids.	Proline	94-101	proline/serine-rich coiled-coil 1	Mus musculus	12-16
10585940-3	1999	Titin"s force arises from its extensible I-band region, which consists of two main segment types: serially linked immunoglobulin-like domains (tandem Ig segments) interrupted with a proline (P)-, glutamate (E)-, valine (V)-, and lysine (K)-rich segment called PEVK segment.	Proline	182-189	titin	Homo sapiens	0-5
10585456-2	1999	We have identified a natural mutation at the -30 amino acid position of the angiotensinogen signal peptide, in which an arginine is replaced by a proline (R-30P).	Proline	146-153	angiotensinogen	Homo sapiens	76-91
10585457-2	1999	Like many G protein-coupled receptors, the gonadotropin-releasing hormone (GnRH) receptor contains an apolar amino acid in this region at a constant distance from conserved Pro and Tyr/Asn residues in the fifth transmembrane domain (TM V).	Proline	173-176	gonadotropin releasing hormone receptor	Homo sapiens	43-89
10574967-7	1999	Docking of the computed low energy conformations for the C-terminal peptide with those for a recently defined proline-rich regulatory region from the N-terminal domain of p53 suggests a unique low energy complex between the two peptide domains.	Proline	110-117	tumor protein p53	Homo sapiens	171-174
10836047-0	1999	7-Azabicycloheptane carboxylic acid: a proline replacement in a boroarginine thrombin inhibitor.	Proline	39-46	coagulation factor II, thrombin	Homo sapiens	77-85
10836047-1	1999	[formula: see text] The synthesis of thrombin inhibitor 3, which incorporates conformationally constrained 7-azabicycloheptane carboxylic acid (1) as a proline replacement, is described.	Proline	152-159	coagulation factor II, thrombin	Homo sapiens	37-45
10836047-2	1999	The inhibition constant (Ki(thrombin) = 2.9 nM) indicates that 1 is a reasonable replacement of proline in the formation of a beta-turn tripeptide mimetic.	Proline	96-103	coagulation factor II, thrombin	Homo sapiens	28-36
10647180-3	1999	The transcriptional activity and synergistic effect of Smad4 require a stretch of proline-rich sequence, the SMAD-activation domain (SAD), located N-terminal of the MH2 domain.	Proline	82-89	SMAD family member 4	Homo sapiens	55-60
10602521-3	1999	The proline rich domain of murine p53 is a substrate for phosphorylation, in vitro and in cultured cells, by the p42ERK2 and p44ERK1 mitogen-activated protein (MAP) kinases.	Proline	4-11	transformation related protein 53, pseudogene	Mus musculus	34-37
10602521-3	1999	The proline rich domain of murine p53 is a substrate for phosphorylation, in vitro and in cultured cells, by the p42ERK2 and p44ERK1 mitogen-activated protein (MAP) kinases.	Proline	4-11	mitogen-activated protein kinase 3	Mus musculus	125-132
10602521-6	1999	In contrast, human p53 is not a substrate for recombinant MAP kinase nor are there any detectable levels of protein kinase activity in stimulated human cell extracts which phosphorylate the proline rich domain of human p53 in vitro.	Proline	190-197	tumor protein p53	Homo sapiens	219-222
10606845-0	1999	Novel proline substitution mutations in keratin 16 in two cases of pachyonychia congenita type 1.	Proline	6-13	keratin 16	Homo sapiens	40-50
10654085-8	1999	Tat2p can take up Phe, Trp and Tyr; Put4p can transport Ala, Gly and Pro; while Can1p, Lyp1p and the previously uncharacterized Alp1p are specific for the cationic amino acids.	Proline	69-72	aromatic amino acid transmembrane transporter TAT2	Saccharomyces cerevisiae S288C	0-5
10654085-8	1999	Tat2p can take up Phe, Trp and Tyr; Put4p can transport Ala, Gly and Pro; while Can1p, Lyp1p and the previously uncharacterized Alp1p are specific for the cationic amino acids.	Proline	69-72	proline permease PUT4	Saccharomyces cerevisiae S288C	36-41
10647890-2	1999	A common p53 polymorphism at codon-72 of exon 4 results in translation to either arginine or proline.	Proline	93-100	tumor protein p53	Homo sapiens	9-12
10601992-1	1999	The proline-, glutamic acid-, serine- and threonine-enriched protein tyrosine phosphatase PEP, which is expressed primarily in hematopoietic cells, was recently discovered to be physically associated with the 50-kDa cytosolic protein tyrosine kinase (PTK) Csk, an important suppressor of Src family PTK, including Lck and Fyn in T cells.	Proline	4-11	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	61-89
10601992-1	1999	The proline-, glutamic acid-, serine- and threonine-enriched protein tyrosine phosphatase PEP, which is expressed primarily in hematopoietic cells, was recently discovered to be physically associated with the 50-kDa cytosolic protein tyrosine kinase (PTK) Csk, an important suppressor of Src family PTK, including Lck and Fyn in T cells.	Proline	4-11	progestagen associated endometrial protein	Homo sapiens	90-93
10601992-1	1999	The proline-, glutamic acid-, serine- and threonine-enriched protein tyrosine phosphatase PEP, which is expressed primarily in hematopoietic cells, was recently discovered to be physically associated with the 50-kDa cytosolic protein tyrosine kinase (PTK) Csk, an important suppressor of Src family PTK, including Lck and Fyn in T cells.	Proline	4-11	protein tyrosine kinase 2 beta	Homo sapiens	251-254
10601992-1	1999	The proline-, glutamic acid-, serine- and threonine-enriched protein tyrosine phosphatase PEP, which is expressed primarily in hematopoietic cells, was recently discovered to be physically associated with the 50-kDa cytosolic protein tyrosine kinase (PTK) Csk, an important suppressor of Src family PTK, including Lck and Fyn in T cells.	Proline	4-11	C-terminal Src kinase	Homo sapiens	256-259
10601992-1	1999	The proline-, glutamic acid-, serine- and threonine-enriched protein tyrosine phosphatase PEP, which is expressed primarily in hematopoietic cells, was recently discovered to be physically associated with the 50-kDa cytosolic protein tyrosine kinase (PTK) Csk, an important suppressor of Src family PTK, including Lck and Fyn in T cells.	Proline	4-11	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	288-291
10601992-1	1999	The proline-, glutamic acid-, serine- and threonine-enriched protein tyrosine phosphatase PEP, which is expressed primarily in hematopoietic cells, was recently discovered to be physically associated with the 50-kDa cytosolic protein tyrosine kinase (PTK) Csk, an important suppressor of Src family PTK, including Lck and Fyn in T cells.	Proline	4-11	protein tyrosine kinase 2 beta	Homo sapiens	299-302
10601992-1	1999	The proline-, glutamic acid-, serine- and threonine-enriched protein tyrosine phosphatase PEP, which is expressed primarily in hematopoietic cells, was recently discovered to be physically associated with the 50-kDa cytosolic protein tyrosine kinase (PTK) Csk, an important suppressor of Src family PTK, including Lck and Fyn in T cells.	Proline	4-11	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	314-317
10601992-1	1999	The proline-, glutamic acid-, serine- and threonine-enriched protein tyrosine phosphatase PEP, which is expressed primarily in hematopoietic cells, was recently discovered to be physically associated with the 50-kDa cytosolic protein tyrosine kinase (PTK) Csk, an important suppressor of Src family PTK, including Lck and Fyn in T cells.	Proline	4-11	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	322-325
10561611-2	1999	The antimicrobial peptide gaegurin displays alpha-helical structure and has a central proline residue (P14).	Proline	86-93	ribonuclease P/MRP subunit p14	Homo sapiens	103-106
10561611-5	1999	Chemical-shift analysis indicated that both of the peptides formed curved helices and that P14 showed diminished stability in the region around the central proline.	Proline	156-163	ribonuclease P/MRP subunit p14	Homo sapiens	91-94
10659563-1	1999	A polymorphism in codon 52 of the human thyrotropin receptor results in a proline to threonine substitution in the extracellular domain of the receptor, but the association with autoimmune thyroid disease has been uncertain and there is no report the prevalence of this polymorphism in Orientals.	Proline	74-81	thyroid stimulating hormone receptor	Homo sapiens	40-60
10590261-2	1999	Analysis of HS1BP3 cDNA indicates several potentially important segments, including a PX domain, a leucine zipper, immunoreceptor tyrosine-based inhibitory motif-like motifs and proline-rich regions.	Proline	178-185	HCLS1 binding protein 3	Homo sapiens	12-18
10577847-9	1999	We identified a single nucleotide polymorphism (SNP) affecting the third base of the triplet codon for a proline (CCC or CCA) in the highly conserved bipartite activation region (viz, A or C at position 1002 numbering from the translation start site of Ik-1) within our Ikaros clones.	Proline	105-112	IKAROS family zinc finger 1	Homo sapiens	253-257
10577847-9	1999	We identified a single nucleotide polymorphism (SNP) affecting the third base of the triplet codon for a proline (CCC or CCA) in the highly conserved bipartite activation region (viz, A or C at position 1002 numbering from the translation start site of Ik-1) within our Ikaros clones.	Proline	105-112	IKAROS family zinc finger 1	Homo sapiens	270-276
10569772-15	1999	The PspA- and PspC-cross-reactive antibodies were directed to the proline-rich domain present in both molecules.	Proline	66-73	surfactant associated protein A1	Mus musculus	4-8
10567556-2	1999	DOKL contains features of intracellular signaling molecules, including an N-terminal PH (pleckstrin homology) domain, a central PTB (phosphotyrosine binding) domain, and a C-terminal domain with multiple potential tyrosine phosphorylation sites and proline-rich regions, which might serve as docking sites for SH2- and SH3-containing proteins.	Proline	249-256	docking protein 3	Homo sapiens	0-4
10567356-2	1999	HPK1 interacts, through its proline-rich domains, with growth factor receptor-bound 2 (Grb2), CT10-regulated kinase (Crk), and Crk-like (CrkL) adaptor proteins.	Proline	28-35	mitogen-activated protein kinase kinase kinase kinase 1	Mus musculus	0-4
10567372-8	1999	The putative active site residues serine, aspartic acid, and histidine of QPP show an ordering of the catalytic triad similar to that seen in the post-proline cleaving exopeptidases prolylcarboxypeptidase and CD26/dipeptidyl peptidase IV.	Proline	151-158	dipeptidyl peptidase 7	Homo sapiens	74-77
10567356-2	1999	HPK1 interacts, through its proline-rich domains, with growth factor receptor-bound 2 (Grb2), CT10-regulated kinase (Crk), and Crk-like (CrkL) adaptor proteins.	Proline	28-35	growth factor receptor bound protein 2	Mus musculus	55-85
10567372-8	1999	The putative active site residues serine, aspartic acid, and histidine of QPP show an ordering of the catalytic triad similar to that seen in the post-proline cleaving exopeptidases prolylcarboxypeptidase and CD26/dipeptidyl peptidase IV.	Proline	151-158	dipeptidyl peptidase 4	Homo sapiens	209-213
10567372-8	1999	The putative active site residues serine, aspartic acid, and histidine of QPP show an ordering of the catalytic triad similar to that seen in the post-proline cleaving exopeptidases prolylcarboxypeptidase and CD26/dipeptidyl peptidase IV.	Proline	151-158	dipeptidyl peptidase 4	Homo sapiens	214-237
10567356-2	1999	HPK1 interacts, through its proline-rich domains, with growth factor receptor-bound 2 (Grb2), CT10-regulated kinase (Crk), and Crk-like (CrkL) adaptor proteins.	Proline	28-35	growth factor receptor bound protein 2	Mus musculus	87-91
10567372-9	1999	The post-proline cleaving activity of QPP has an unusually broad pH range in that it is able to cleave substrate molecules at acidic pH as well as at neutral pH.	Proline	9-16	dipeptidyl peptidase 7	Homo sapiens	38-41
10556023-4	1999	Kinesin-C is predicted to contain a kinesin motor domain at its carboxy terminus, linked to a segment of alpha-helical coiled-coil 950 amino acid residues long, ending with an amino-terminal proline-rich tail domain.	Proline	191-198	calmodulin-binding carboxy-terminal kinesin	Strongylocentrotus purpuratus	0-9
10597310-5	1999	Using yeast 2-hybrid techniques, we found that PML and a related RING protein, Z, bind the proline rich homeodomain protein (PRH) through their RING domains.	Proline	91-98	PML nuclear body scaffold	Homo sapiens	47-50
10597310-5	1999	Using yeast 2-hybrid techniques, we found that PML and a related RING protein, Z, bind the proline rich homeodomain protein (PRH) through their RING domains.	Proline	91-98	hematopoietically expressed homeobox	Homo sapiens	125-128
10588661-6	1999	This additional actin-binding site bound to F-actin with a K(d) of approximately 1 microM, decorated actin stress fiber-like structures in transfected cells, and was mapped to a peptide between the two proline-rich peptides in the N terminus of espin.	Proline	202-209	espin	Homo sapiens	245-250
11212339-8	1999	In contrast to other prolyl isomerases (peptidyl-prolyl isomerases, PPlases), Pin1 has an extremely high degree of substrate specificity, specifically isomerizing phosphorylated Ser/Thr-Pro bonds.	Proline	186-189	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	78-82
11212339-12	1999	Thus, we have proposed a novel signaling regulatory mechanism, where protein phosphorylation creates binding sites for Pin1, which can then latch on to and isomerize the phosphorylated Ser/Thr-Pro peptide bond.	Proline	193-196	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	119-123
10542231-0	1999	The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.	Proline	58-65	amphiphysin	Homo sapiens	34-45
10551867-2	1999	This protein termed somatostatin receptor interacting protein is characterized by a novel domain structure, consisting of six N-terminal ankyrin repeats followed by SH3 and PDZ domains, several proline-rich regions, and a C-terminal sterile alpha motif.	Proline	194-201	SH3 and multiple ankyrin repeat domains 1	Homo sapiens	20-61
10542231-0	1999	The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.	Proline	58-65	synaptojanin 1	Homo sapiens	81-95
10542231-1	1999	The proline-rich domain of synaptojanin 1, a synaptic protein with phosphatidylinositol phosphatase activity, binds to amphiphysin and to a family of recently discovered proteins known as the SH3p4/8/13, the SH3-GL, or the endophilin family.	Proline	4-11	synaptojanin 1	Homo sapiens	27-41
10542231-1	1999	The proline-rich domain of synaptojanin 1, a synaptic protein with phosphatidylinositol phosphatase activity, binds to amphiphysin and to a family of recently discovered proteins known as the SH3p4/8/13, the SH3-GL, or the endophilin family.	Proline	4-11	amphiphysin	Homo sapiens	119-130
10542231-5	1999	The comparison of the results obtained by phage display and substitution analysis permitted the identification of proline and arginine at positions 4 and 6 in the PIRPSR and PTIPPR target sequence as the major determinants of the recognition specificity mediated by the SH3 domain of amphiphysin 1.	Proline	114-121	amphiphysin	Homo sapiens	284-295
10758736-1	1999	BACKGROUND: The PlA1/A2 polymorphism of the human platelet membrane glycoprotein IIIa gene cause T--&gt;C transition in the exon ii (position 1565) resulting in the leucine--&gt;proline substitution in amino-acid sequence.	Proline	178-185	POU class 2 homeobox 3	Homo sapiens	16-20
10521295-9	1999	The founder Romani mutation identified in this study is a single nucleotide substitution in GK1 resulting in the replacement of the conserved proline residue at amino acid position 28 with threonine (P28T).	Proline	142-149	galactokinase 1	Homo sapiens	92-95
10553987-7	1999	Also, the change from proline to serine suggests that this mutation might contribute to tau hyperphosphorylation.	Proline	22-29	microtubule associated protein tau	Homo sapiens	88-91
10542110-2	1999	In Src, the SH3 domain (Src homology 3) binds proteins at specific, proline-rich sequences, while the SH2 domain (Src homology 2) binds phosphotyrosine-containing sequences.	Proline	68-75	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	3-6
10542110-2	1999	In Src, the SH3 domain (Src homology 3) binds proteins at specific, proline-rich sequences, while the SH2 domain (Src homology 2) binds phosphotyrosine-containing sequences.	Proline	68-75	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	24-27
10542110-2	1999	In Src, the SH3 domain (Src homology 3) binds proteins at specific, proline-rich sequences, while the SH2 domain (Src homology 2) binds phosphotyrosine-containing sequences.	Proline	68-75	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	24-27
10559988-4	1999	This structure provides an explanation for the specificity of CDK2 towards the proline that follows the phosphorylatable serine of the substrate peptide, and the requirement for the basic residue in the P+3 position of the substrate.	Proline	79-86	cyclin dependent kinase 2	Homo sapiens	62-66
10569726-0	1999	Hb Toulon [alpha77(EF6)Pro-->His]: a new variant due to a mutation in the alpha2 gene found during measurement of glycated hemoglobin.	Proline	23-26	glycoprotein hormone subunit alpha 2	Homo sapiens	74-80
10545505-7	1999	Mapping of the proteolytic cleavage fragments of pp125(FAK) predicts a dissociation of the focal adhesion targeting (FAT) sequence and second proline-rich domain from the tyrosine kinase domain and integrin-binding sequence.	Proline	142-149	protein tyrosine kinase 2	Homo sapiens	55-58
10545531-5	1999	We identified 3 novel IPF-1 mutations, including 2 substitutions (Q59L and D76N) and an in-frame proline insertion (InsCCG243).	Proline	97-104	pancreatic and duodenal homeobox 1	Homo sapiens	22-27
10544233-3	1999	Here we have shown by co-immunoprecipitation that FAP-1 also binds to the p75(NTR) cytoplasmic domain in vivo through the interaction between the third PDZ domain of FAP-1 and C-terminal Ser-Pro-Val residues of p75(NTR).	Proline	191-194	protein tyrosine phosphatase non-receptor type 13	Homo sapiens	50-55
10535961-3	1999	Accordingly, we used the proline-rich third intracellular loop of the beta1-AR either as a glutathione S-transferase fusion protein in biochemical "pull-down" assays or as bait in the yeast two-hybrid system to search for interacting proteins.	Proline	25-32	adrenoceptor beta 1	Homo sapiens	70-78
10535961-8	1999	Thus, our studies demonstrate a role of the SH3p4/p8/p13 protein family in beta1-AR signaling and suggest that interaction between proline-rich motifs and SH3-containing proteins may represent a previously underappreciated aspect of G-protein coupled receptor signaling.	Proline	131-138	SH3 domain containing GRB2 like 2, endophilin A1	Homo sapiens	44-49
10535961-8	1999	Thus, our studies demonstrate a role of the SH3p4/p8/p13 protein family in beta1-AR signaling and suggest that interaction between proline-rich motifs and SH3-containing proteins may represent a previously underappreciated aspect of G-protein coupled receptor signaling.	Proline	131-138	H3 histone pseudogene 6	Homo sapiens	53-56
10544233-3	1999	Here we have shown by co-immunoprecipitation that FAP-1 also binds to the p75(NTR) cytoplasmic domain in vivo through the interaction between the third PDZ domain of FAP-1 and C-terminal Ser-Pro-Val residues of p75(NTR).	Proline	191-194	neurotensin receptor 1	Homo sapiens	74-82
10535961-8	1999	Thus, our studies demonstrate a role of the SH3p4/p8/p13 protein family in beta1-AR signaling and suggest that interaction between proline-rich motifs and SH3-containing proteins may represent a previously underappreciated aspect of G-protein coupled receptor signaling.	Proline	131-138	adrenoceptor beta 1	Homo sapiens	75-83
10544233-3	1999	Here we have shown by co-immunoprecipitation that FAP-1 also binds to the p75(NTR) cytoplasmic domain in vivo through the interaction between the third PDZ domain of FAP-1 and C-terminal Ser-Pro-Val residues of p75(NTR).	Proline	191-194	protein tyrosine phosphatase non-receptor type 13	Homo sapiens	166-171
10544233-3	1999	Here we have shown by co-immunoprecipitation that FAP-1 also binds to the p75(NTR) cytoplasmic domain in vivo through the interaction between the third PDZ domain of FAP-1 and C-terminal Ser-Pro-Val residues of p75(NTR).	Proline	191-194	TNF receptor superfamily member 1B	Homo sapiens	74-77
10544233-3	1999	Here we have shown by co-immunoprecipitation that FAP-1 also binds to the p75(NTR) cytoplasmic domain in vivo through the interaction between the third PDZ domain of FAP-1 and C-terminal Ser-Pro-Val residues of p75(NTR).	Proline	191-194	neurotensin receptor 1	Homo sapiens	78-81
10557072-5	1999	ULKs and UNC-51 share a typical domain structure of an amino-terminal kinase domain, a central proline/serine rich (PS) domain, and a carboxy-terminal (C) domain.	Proline	95-102	Serine/threonine-protein kinase unc-51	Caenorhabditis elegans	9-15
10521482-3	1999	Several structural features of c-Cbl, including the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosine and phosphoserine residues, mediate the association of c-Cbl with other components of these complexes.	Proline	84-91	Cbl proto-oncogene	Homo sapiens	31-36
10521482-3	1999	Several structural features of c-Cbl, including the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosine and phosphoserine residues, mediate the association of c-Cbl with other components of these complexes.	Proline	84-91	Cbl proto-oncogene	Homo sapiens	198-203
10521485-8	1999	nArgBP2 bound to the proline-rich region of SAPAP via its third SH3 domain and was coimmunoprecipitated with SAPAP from the extract of rat brain.	Proline	21-28	sorbin and SH3 domain containing 2	Rattus norvegicus	0-7
10571044-2	1999	The cbl-c gene is predicted to encode a protein of 52 kDa that has a phosphotyrosine-binding domain, a RING finger and a proline-rich region.	Proline	121-128	Cbl proto-oncogene C	Homo sapiens	4-9
10526173-0	1999	Conservation of the central proline-rich (PxxP) motifs of human immunodeficiency virus type 1 Nef protein during the disease progression in two hemophiliac patients.	Proline	28-35	Nef	Human immunodeficiency virus 1	94-97
10514515-2	1999	Here, we report the identification in human erythroblasts of a novel cDNA, designated HUT11A, which encodes a protein identical to the previously reported erythroid HUT11 urea transporter, except for a Lys(44) --&gt; Glu substitution and a Val-Gly dipeptide deletion after proline 227, which leads to a polypeptide of 389 residues versus 391 in HUT11.	Proline	273-280	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	86-91
10514515-2	1999	Here, we report the identification in human erythroblasts of a novel cDNA, designated HUT11A, which encodes a protein identical to the previously reported erythroid HUT11 urea transporter, except for a Lys(44) --&gt; Glu substitution and a Val-Gly dipeptide deletion after proline 227, which leads to a polypeptide of 389 residues versus 391 in HUT11.	Proline	273-280	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	165-170
10514433-8	1999	On the other hand, the highly conserved residues Pro(149), Ile(160), and Leu(164) in the F-box domain of FWD1 were dispensable for binding to Skp1.	Proline	49-52	beta-transducin repeat containing protein	Mus musculus	105-109
10537323-7	1999	Deletion of the helical-proline-rich region of the protein blocked the mobility shift and EMS1 phosphorylation.	Proline	24-31	cortactin	Homo sapiens	90-94
10537323-9	1999	These data identify MEK as an important intermediate involved in EMS1 phosphorylation and highlight the helical-proline-rich region as a key regulatory domain.	Proline	112-119	mitogen-activated protein kinase kinase 7	Homo sapiens	20-23
10518561-5	1999	BRDG1 contains a proline-rich motif, a PH domain, and multiple tyrosine residues that are potential target sites for Src homology 2 domains.	Proline	17-24	signal transducing adaptor family member 1	Homo sapiens	0-5
10527873-0	1999	Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.	Proline	0-7	SH3 and multiple ankyrin repeat domains 2	Rattus norvegicus	41-48
10527873-0	1999	Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.	Proline	0-7	SH3 and multiple ankyrin repeat domains 3	Rattus norvegicus	53-60
10529218-11	1999	Addition of poly-L-proline to culture medium, or coexpression with the N-terminus of COLQ including the proline-rich attachment domain (Q(N)PRAD), increased the amount of tetrameric wild-type BChE from 10 to 70%, but had no effect on the G534stop (lacking 41 C-terminal residues) and the aromatics-off mutants.	Proline	19-26	butyrylcholinesterase	Homo sapiens	192-196
10524630-6	1999	Mutation of Pro 210/211 to leucine in the inhibitory wedge of the Pro137Cys mutant restored its ability to activate c-Src, indicating that dimerization may inhibit full-length RPTPalpha activity in a manner stereochemically consistent with RPTPalpha crystal structures.	Proline	12-15	protein tyrosine phosphatase, receptor type, A	Mus musculus	176-185
10524630-6	1999	Mutation of Pro 210/211 to leucine in the inhibitory wedge of the Pro137Cys mutant restored its ability to activate c-Src, indicating that dimerization may inhibit full-length RPTPalpha activity in a manner stereochemically consistent with RPTPalpha crystal structures.	Proline	12-15	protein tyrosine phosphatase, receptor type, A	Mus musculus	240-249
10529174-8	1999	The sequence analysis of the four mutant mna6 alleles revealed that Leu(109) --&gt; Phe, Arg(111) --&gt; Lys, Pro(424) --&gt; Leu, or Pro(438) --&gt; Leu amino acid substitution in Mna6p causes temperature-dependent loss of the 15S rRNA.	Proline	134-137	mitochondrial 37S ribosomal protein NAM9	Saccharomyces cerevisiae S288C	41-45
11213257-2	1999	C-terminal ladder sequence analysis of a bioactive peptide with matrix-assisted laser desorption/ionization mass spectrometry after digestion with carboxypeptidases P and Y showed that it is identical to the antibacterial proline/arginine-rich intestinal peptide PR-39.	Proline	222-229	antibacterial protein PR-39	Sus scrofa	263-268
10529174-8	1999	The sequence analysis of the four mutant mna6 alleles revealed that Leu(109) --&gt; Phe, Arg(111) --&gt; Lys, Pro(424) --&gt; Leu, or Pro(438) --&gt; Leu amino acid substitution in Mna6p causes temperature-dependent loss of the 15S rRNA.	Proline	110-113	mitochondrial 37S ribosomal protein NAM9	Saccharomyces cerevisiae S288C	41-45
15216891-2	1999	The carboxyl-terminal domain of MAP4 is further divided into three subdomains: a region rich in proline and basic residues (Pro-rich region), a region containing four repeats of an assembly-promoting (AP) sequence, which consists of 22 amino acid residues (AP sequence region), and a hydrophobic tail region (Tail region).	Proline	96-103	microtubule-associated protein 4	Bos taurus	32-36
10497187-6	1999	The C terminus of SHP-1L contains a proline-rich motif PVPGPPVLSP, a potential Src homology 3 domain-binding site.	Proline	36-43	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	18-24
10507762-1	1999	PR-39 is an endogenous proline-rich antimicrobial peptide which induces the synthesis of syndecan-1, a transmembrane heparan sulphate proteoglycan involved in cell-to-matrix interactions and wound healing.	Proline	23-30	syndecan 1	Homo sapiens	89-99
10511541-3	1999	Dal5p, the allantoate permease, allows ureidosuccinate uptake (Usa(+)) when cells grow on a poor nitrogen source such as proline.	Proline	121-128	allantoate permease	Saccharomyces cerevisiae S288C	0-5
10511541-4	1999	We find that overproduction of Mks1p allows uptake of ureidosuccinate on ammonia and lack of Mks1p prevents uptake of ureidosuccinate or Dal5p expression on proline.	Proline	157-164	Mks1p	Saccharomyces cerevisiae S288C	93-98
10511541-4	1999	We find that overproduction of Mks1p allows uptake of ureidosuccinate on ammonia and lack of Mks1p prevents uptake of ureidosuccinate or Dal5p expression on proline.	Proline	157-164	allantoate permease	Saccharomyces cerevisiae S288C	137-142
10511541-6	1999	An mks1 ure2 double mutant can take up ureidosuccinate on either ammonia or proline.	Proline	76-83	Mks1p	Saccharomyces cerevisiae S288C	3-7
10511541-6	1999	An mks1 ure2 double mutant can take up ureidosuccinate on either ammonia or proline.	Proline	76-83	glutathione peroxidase	Saccharomyces cerevisiae S288C	8-12
10497239-3	1999	Here we test the hypothesis that this region, rich in proline, glutamic acid, serine, and threonine (PEST) residues, serves as the E2A protein degradation domain (DD).	Proline	54-61	transcription factor 3	Homo sapiens	131-134
11270995-7	1999	DNA synthesis and collagen protein synthesis induced by Ang II for 24 h were measured by [3H]thymidine incorporation and [3H]Proline incorporation, respectively.	Proline	125-132	angiotensinogen	Rattus norvegicus	56-62
10504342-2	1999	Mapping studies identified a region of MAP1B high in serine-proline motifs that is phosphorylated by GSK3beta.	Proline	60-67	microtubule associated protein 1B	Homo sapiens	39-44
10504342-2	1999	Mapping studies identified a region of MAP1B high in serine-proline motifs that is phosphorylated by GSK3beta.	Proline	60-67	glycogen synthase kinase 3 beta	Homo sapiens	101-109
10521528-0	1999	Glutamine synthetase in the phloem plays a major role in controlling proline production To inhibit expression specifically in the phloem, a 274-bp fragment of a cDNA (Gln1-5) encoding cytosolic glutamine synthetase (GS1) from tobacco was placed in the antisense orientation downstream of the cytosolic Cu/Zn superoxide dismutase promoter of Nicotiana plumbaginifolia.	Proline	69-76	glutamine synthetase	Nicotiana tabacum	0-20
10521528-0	1999	Glutamine synthetase in the phloem plays a major role in controlling proline production To inhibit expression specifically in the phloem, a 274-bp fragment of a cDNA (Gln1-5) encoding cytosolic glutamine synthetase (GS1) from tobacco was placed in the antisense orientation downstream of the cytosolic Cu/Zn superoxide dismutase promoter of Nicotiana plumbaginifolia.	Proline	69-76	glutamine synthetase PR-2-like	Nicotiana tabacum	167-173
10589521-10	1999	Compared with oleosin, a conserved proline knot-like motif is located in the central hydrophobic domain of caleosin and assumed to involve in protein assembly onto oil bodies.	Proline	35-42	peroxygenase	Sesamum indicum	107-115
11270995-9	1999	[3H]thymidine incorporation and [3H]proline incorporation in Ang II-induced cardiac fibroblast were inhibited by 59% and 58%, respectively.	Proline	36-43	angiotensinogen	Rattus norvegicus	61-67
10488128-2	1999	We show that deletion of the kinase subunit CTK1 results in an increase in phosphorylation of serine in position 5 (Ser(5)) of the CTD repeat (Tyr(1)-Ser(2)-Pro(3)-Thr(4)-Ser(5)-Pro(6)-Ser(7)) during logarithmic growth.	Proline	157-160	cyclin-dependent serine/threonine protein kinase CTK1	Saccharomyces cerevisiae S288C	44-48
10449610-1	1999	A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells.	Proline	81-88	tumor protein p53	Homo sapiens	34-37
10449610-1	1999	A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells.	Proline	81-88	tumor protein p53	Homo sapiens	163-166
10488079-4	1999	Synamon has seven ankyrin repeats at the NH(2) terminus followed by one src homology 3 domain and one PSD-95/Dlg-A/ZO-1 domain, and several proline-rich regions at the carboxyl terminus.	Proline	140-147	SH3 and multiple ankyrin repeat domains 1	Rattus norvegicus	0-7
10488128-2	1999	We show that deletion of the kinase subunit CTK1 results in an increase in phosphorylation of serine in position 5 (Ser(5)) of the CTD repeat (Tyr(1)-Ser(2)-Pro(3)-Thr(4)-Ser(5)-Pro(6)-Ser(7)) during logarithmic growth.	Proline	178-181	cyclin-dependent serine/threonine protein kinase CTK1	Saccharomyces cerevisiae S288C	44-48
10556563-9	1999	The cleavage between Pro(689)-Gln(690) is the only cleavage site identified in PZP.	Proline	21-24	PZP alpha-2-macroglobulin like	Homo sapiens	79-82
10493799-1	1999	Indolicidin is a 13-residue antimicrobial peptide-amide isolated from the cytoplasmic granules of bovine neutrophils that contains five Trp and three Pro residues.	Proline	150-153	cathelicidin-4	Bos taurus	0-11
10480896-9	1999	USP3 is also only the second known ubiquitin-specific protease capable of efficiently cleaving a ubiquitin-proline bond.	Proline	107-114	ubiquitin specific peptidase 3	Homo sapiens	0-4
10498863-1	1999	Human and mouse Abelson interacting proteins (Abi) are SH3-domain containing proteins that bind to the proline-rich motifs of the Abelson protein tyrosine kinase.	Proline	103-110	Abelson interacting protein	Drosophila melanogaster	46-49
10504254-5	1999	MIF and these two enzymes have an invariant N-terminal proline that serves as a catalytic base.	Proline	55-62	macrophage migration inhibitory factor	Homo sapiens	0-3
10515458-1	1999	We showed in a transient coexpression study that a single proline substitution for any of the five conserved leucine or isoleucine residues located in the envelope (Env) transmembrane protein gp41 zipper motif of the human immunodeficiency virus type 1 dominantly interferes with wild-type Env-mediated viral infectivity.	Proline	58-65	endogenous retrovirus group K member 20	Homo sapiens	165-168
10515458-1	1999	We showed in a transient coexpression study that a single proline substitution for any of the five conserved leucine or isoleucine residues located in the envelope (Env) transmembrane protein gp41 zipper motif of the human immunodeficiency virus type 1 dominantly interferes with wild-type Env-mediated viral infectivity.	Proline	58-65	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	290-293
10481064-1	1999	The Arabidopsis thaliana gene that encodes pyrroline-5-carboxylate reductase (At-P5R), the last enzyme in proline biosynthesis in A. thaliana, is developmentally regulated and is highly expressed in cells that divide rapidly or undergo changes in osmotic potential.	Proline	106-113	pyrroline-5-carboxylate reductase	Arabidopsis thaliana	43-76
10481064-1	1999	The Arabidopsis thaliana gene that encodes pyrroline-5-carboxylate reductase (At-P5R), the last enzyme in proline biosynthesis in A. thaliana, is developmentally regulated and is highly expressed in cells that divide rapidly or undergo changes in osmotic potential.	Proline	106-113	pyrroline-5- carboxylate (P5C) reductase	Arabidopsis thaliana	78-84
10477574-0	1999	A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase.	Proline	86-93	dipeptidyl peptidase 7	Homo sapiens	150-184
10473622-4	1999	To test the role of this interaction in the regulation of Hck kinase activity in living cells, we substituted alanines for prolines 225 and 228 in the linker region and observed that the resulting mutant (Hck-2PA) demonstrated strong transforming activity in a Rat-2 fibroblast focus-forming assay.	Proline	123-131	HCK proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	205-208
10469618-5	1999	It has recently been reported that the extent of p53 dysfunction caused by HPVs depends on the status of a polymorphism at codon 72 of p53, Pro or Arg.	Proline	140-143	tumor protein p53	Homo sapiens	49-52
10493777-4	1999	In human aldose reductase, the role of the non-conserved Pro 216 (Ser in aldehyde reductase) in the binding of coenzyme was examined by site-directed mutagenesis.	Proline	57-60	aldo-keto reductase family 1 member B	Homo sapiens	9-25
10493777-4	1999	In human aldose reductase, the role of the non-conserved Pro 216 (Ser in aldehyde reductase) in the binding of coenzyme was examined by site-directed mutagenesis.	Proline	57-60	aldo-keto reductase family 1 member A1	Homo sapiens	73-91
10499404-13	1999	After treatment with TGF-beta2, proline uptake was significantly greater in both wounded and nonwounded palates in the newborn group and had no effect on collagen synthesis in palates from 15-day gestation animals.	Proline	32-39	transforming growth factor, beta 2	Mus musculus	21-30
10571960-10	1999	This mutation resulted in the change of threonine (codon ACC) at 632 position of TSH receptor protein for proline (codon CCC).	Proline	106-113	thyroid stimulating hormone receptor	Homo sapiens	81-93
10469649-1	1999	The p12 Gag protein of Moloney murine leukemia virus is a small polypeptide of unknown function, containing two proline-rich motifs.	Proline	112-119	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	4-7
10479347-0	1999	Preparation of a microcrystalline suspension formulation of Lys(B28)Pro(B29)-human insulin with ultralente properties.	Proline	68-71	insulin	Homo sapiens	83-90
10485845-4	1999	Protein-protein interaction assays suggest that Gro and Rpd3 form a complex in vivo and that they interact directly via the glycine/proline rich (GP) domain in Gro.	Proline	132-139	groucho	Drosophila melanogaster	48-51
10485845-4	1999	Protein-protein interaction assays suggest that Gro and Rpd3 form a complex in vivo and that they interact directly via the glycine/proline rich (GP) domain in Gro.	Proline	132-139	Histone deacetylase 1	Drosophila melanogaster	56-60
10485845-4	1999	Protein-protein interaction assays suggest that Gro and Rpd3 form a complex in vivo and that they interact directly via the glycine/proline rich (GP) domain in Gro.	Proline	132-139	groucho	Drosophila melanogaster	160-163
10436181-10	1999	Two conserved amino acid positions (glu(31) and pro(94)) are most probably homologous to the interleukin-4 signalling residues.	Proline	48-51	interleukin 4	Bos taurus	93-106
10477140-9	1999	High glucose as well as exogenous TGF-beta1 also increased [3H]-proline incorporation, alpha2(I) collagen mRNA, and type I collagen protein (measured by immunoassay).	Proline	64-71	transforming growth factor beta 1	Homo sapiens	34-43
10486177-0	1999	The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington"s disease.	Proline	44-51	insulin like growth factor 1	Homo sapiens	4-9
10486177-3	1999	Using this animal model of Huntington"s disease, we investigated the ability of the insulin-like growth factor-I (IGF-I) amino-terminal tripeptide glycine-proline-glutamate (GPE) to protect striatal neurons from degeneration.	Proline	155-162	insulin like growth factor 1	Homo sapiens	84-112
10486177-3	1999	Using this animal model of Huntington"s disease, we investigated the ability of the insulin-like growth factor-I (IGF-I) amino-terminal tripeptide glycine-proline-glutamate (GPE) to protect striatal neurons from degeneration.	Proline	155-162	insulin like growth factor 1	Homo sapiens	114-119
10489405-7	1999	[Pro(11), D-Ala(12)]Ang I (10(-8) to 10(-5) mol/L), a chymase-specific substrate, provoked similar responses in rat and hamster arteries; chymostatin, but not temocapril, attenuated the responses.	Proline	1-4	chymase 1	Rattus norvegicus	54-61
10425273-2	1999	A polymorphism at codon 72 of p53 results in translation to either arginine (p53Arg) or proline (p53Pro), and recent study showed that Caucasian women with arginine form of p53 are more susceptible to HPV-associated carcinoma of the cervix.	Proline	88-95	tumor protein p53	Homo sapiens	30-33
10589458-3	1999	In the present study, we examined the polymorphism in mannose 6-phosphate/insulin-like growth factor 2 receptor (M6p/Igf2r) gene and found that the DRH rat showed CCC (Proline)-type polymorphism in exon 48 and the Donryu rat had GCC (Alanine) sequence.	Proline	168-175	insulin-like growth factor 2 receptor	Rattus norvegicus	113-122
10479347-1	1999	The monomeric analogue, Lys(B28)Pro(B29)-human insulin (LysPro), has been crystallized using similar conditions employed to prepare extended-acting insulin ultralente formulations.	Proline	32-35	insulin	Homo sapiens	47-54
10468633-1	1999	Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein-protein interaction domains: a phosphotyrosine-binding domain and a proline-rich region (PRR) that functions as an SH3-binding domain.	Proline	178-185	numb	Drosophila melanogaster	59-63
10455105-5	1999	The proline-rich region present in the carboxyl termini of alpha(1B) binds to the SH3 domain of CASK.	Proline	4-11	calcium/calmodulin dependent serine protein kinase	Homo sapiens	96-100
10446171-8	1999	Maximal transactivation by SOX9 requires both the C-terminal domain rich in proline, glutamine, and serine and the adjacent domain composed entirely of proline, glutamine, and alanine.	Proline	76-83	SRY-box transcription factor 9	Homo sapiens	27-31
10446171-8	1999	Maximal transactivation by SOX9 requires both the C-terminal domain rich in proline, glutamine, and serine and the adjacent domain composed entirely of proline, glutamine, and alanine.	Proline	152-159	SRY-box transcription factor 9	Homo sapiens	27-31
10432316-7	1999	In addition, we identified the transcriptional regulatory domain of NF1-B, which is enriched with proline and serine residues.	Proline	98-105	neurofibromin 1	Rattus norvegicus	68-71
10448092-1	1999	Myc-associated zinc finger protein (MAZ) is a transcription factor that contains proline-rich, alanine repeats and six C(2)H(2)-type zinc finger motifs, as well as five putative sites of phosphorylation by casein kinase II (CKII).	Proline	81-88	MYC associated zinc finger protein	Homo sapiens	0-34
10448092-1	1999	Myc-associated zinc finger protein (MAZ) is a transcription factor that contains proline-rich, alanine repeats and six C(2)H(2)-type zinc finger motifs, as well as five putative sites of phosphorylation by casein kinase II (CKII).	Proline	81-88	MYC associated zinc finger protein	Homo sapiens	36-39
10441499-1	1999	Delta(1)-Pyrroline-5-carboxylate synthetase 1 (P5CS1) is the rate-limiting enzyme in the biosynthesis of proline by Arabidopsis thaliana.	Proline	105-112	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	0-45
10458913-8	1999	The activation domain is highly proline-rich and, similar to mouse LKLF, contains 22% proline residues.	Proline	32-39	Kruppel-like factor 2 (lung)	Mus musculus	67-71
10458913-8	1999	The activation domain is highly proline-rich and, similar to mouse LKLF, contains 22% proline residues.	Proline	86-93	Kruppel-like factor 2 (lung)	Mus musculus	67-71
10458914-1	1999	The preferential screening of cDNA libraries derived from the mouse osteoblastic cell line MC3T3-E1 has yielded a cDNA clone encoding a 442-amino-acid protein designated STAP (signal transduction and adaptor protein), which contains several motifs shared among transcription factors and adaptors such as a Zn-finger like motif, a proline-rich domain, and a PEST sequence.	Proline	330-337	sequestosome 1	Mus musculus	170-174
10458914-1	1999	The preferential screening of cDNA libraries derived from the mouse osteoblastic cell line MC3T3-E1 has yielded a cDNA clone encoding a 442-amino-acid protein designated STAP (signal transduction and adaptor protein), which contains several motifs shared among transcription factors and adaptors such as a Zn-finger like motif, a proline-rich domain, and a PEST sequence.	Proline	330-337	sequestosome 1	Mus musculus	176-215
10441499-1	1999	Delta(1)-Pyrroline-5-carboxylate synthetase 1 (P5CS1) is the rate-limiting enzyme in the biosynthesis of proline by Arabidopsis thaliana.	Proline	105-112	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	47-52
10441506-3	1999	However, the amino acid sequence of PKNbeta differed from that of PKNalpha in the region immediately amino-terminal to the catalytic domain, which contained two distinct proline-rich sequences consistent with the class II consensus sequence, PXXPXR, for binding to SH3 domain.	Proline	170-177	protein kinase N3	Homo sapiens	36-43
10441506-3	1999	However, the amino acid sequence of PKNbeta differed from that of PKNalpha in the region immediately amino-terminal to the catalytic domain, which contained two distinct proline-rich sequences consistent with the class II consensus sequence, PXXPXR, for binding to SH3 domain.	Proline	170-177	protein kinase N1	Homo sapiens	66-74
10428773-8	1999	The data strongly suggest that P. bursaria Chlorella virus-1 expresses proteins in which many prolines become hydroxylated to 4-hydroxyproline by a novel viral prolyl 4-hydroxylase.	Proline	94-102	Prolyl 4-hydroxylase	Paramecium bursaria Chlorella virus 1	160-180
10430626-0	1999	Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation.	Proline	0-7	CD28 molecule	Homo sapiens	20-24
10446133-9	1999	hATB(0+) was found to transport both neutral and cationic amino acids, with the highest affinity for hydrophobic amino acids and the lowest affinity for proline.	Proline	153-160	solute carrier family 1 member 5	Homo sapiens	0-8
10430626-0	1999	Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation.	Proline	0-7	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	33-36
10430626-0	1999	Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation.	Proline	0-7	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	62-65
10430626-3	1999	Recent crystal structures of Src kinases suggest that an important mechanism of kinase activation is via engagement of the Src homology (SH)3 domain by proline-containing sequences.	Proline	152-159	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	29-32
10430626-3	1999	Recent crystal structures of Src kinases suggest that an important mechanism of kinase activation is via engagement of the Src homology (SH)3 domain by proline-containing sequences.	Proline	152-159	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	123-126
10430626-5	1999	Here we demonstrate that Lck and Fyn can be activated by proline motifs in the CD28 and CD2 proteins, respectively.	Proline	57-64	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-28
10430626-5	1999	Here we demonstrate that Lck and Fyn can be activated by proline motifs in the CD28 and CD2 proteins, respectively.	Proline	57-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	33-36
10430626-5	1999	Here we demonstrate that Lck and Fyn can be activated by proline motifs in the CD28 and CD2 proteins, respectively.	Proline	57-64	CD28 molecule	Homo sapiens	79-83
10430626-5	1999	Here we demonstrate that Lck and Fyn can be activated by proline motifs in the CD28 and CD2 proteins, respectively.	Proline	57-64	CD2 molecule	Homo sapiens	79-82
10430626-6	1999	Supporting a role for Lck in CD28 signaling, we demonstrate that CD28 signaling in both transformed and primary T cells requires Lck as well as proline residues in CD28.	Proline	144-151	CD28 molecule	Homo sapiens	65-69
10430626-6	1999	Supporting a role for Lck in CD28 signaling, we demonstrate that CD28 signaling in both transformed and primary T cells requires Lck as well as proline residues in CD28.	Proline	144-151	CD28 molecule	Homo sapiens	65-69
10444327-5	1999	USP15 can also cleave the ubiquitin-proline bond, a property previously unique to Unp/UNP.	Proline	36-43	ubiquitin specific peptidase 15	Homo sapiens	0-5
10417349-5	1999	Two novel forms were derived from the Daf-TM gene but the transmembrane sequence defined previously was replaced by a unique GPI-anchor addition sequence; one clone also had part of the serine/threonine/proline (STP) region deleted.	Proline	203-210	CD55 molecule, decay accelerating factor for complement B	Mus musculus	38-44
10502033-19	1999	Introduction of a proline residue in position 111 of Mal d 1 and in position 112 of Bet v 1 led to a drastic reduction of allergenicity of both the pollen and the food allergen, obviously also removing the cross-reactive epitope.	Proline	18-25	major allergen Mal d 1	Malus domestica	53-60
10502033-19	1999	Introduction of a proline residue in position 111 of Mal d 1 and in position 112 of Bet v 1 led to a drastic reduction of allergenicity of both the pollen and the food allergen, obviously also removing the cross-reactive epitope.	Proline	18-25	delta/notch like EGF repeat containing	Homo sapiens	84-87
10444327-5	1999	USP15 can also cleave the ubiquitin-proline bond, a property previously unique to Unp/UNP.	Proline	36-43	ubiquitin specific peptidase 4	Homo sapiens	82-85
10444327-5	1999	USP15 can also cleave the ubiquitin-proline bond, a property previously unique to Unp/UNP.	Proline	36-43	ubiquitin specific peptidase 4	Homo sapiens	86-89
10417180-6	1999	Proline-rich Bac5 peptides are highly conserved in ruminants and may contribute significantly to their innate host defense mechanisms.	Proline	0-7	cathelicidin-2	Ovis aries	13-17
10481267-2	1999	Eps15 has a tripartite structure comprising a NH2-terminal portion, which contains three EH domains, a central putative coiled-coil region, and a COOH-terminal domain containing multiple copies of the amino acid triplet Aspartate-Proline-Phenylalanine.	Proline	230-237	epidermal growth factor receptor pathway substrate 15	Mus musculus	0-5
10490782-10	1999	In addition, individuals found to simultaneously exhibit homozygosity of the common allele of all three polymorphisms (genotypes: Arg/Arg, pro/pro and II/II) exhibited significantly elevated fasting insulin levels (Pc = 0.03).	Proline	139-142	insulin	Homo sapiens	199-206
10421786-3	1999	However, disruption of a membrane-proximal proline-rich sequence motif ("box1") in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3, but also IL-4-triggered activation of STAT5 and concomitant cell proliferation.	Proline	43-50	interleukin 4 receptor, alpha	Mus musculus	115-120
10421786-3	1999	However, disruption of a membrane-proximal proline-rich sequence motif ("box1") in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3, but also IL-4-triggered activation of STAT5 and concomitant cell proliferation.	Proline	43-50	Janus kinase 1	Mus musculus	197-201
10421786-3	1999	However, disruption of a membrane-proximal proline-rich sequence motif ("box1") in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3, but also IL-4-triggered activation of STAT5 and concomitant cell proliferation.	Proline	43-50	Janus kinase 3	Mus musculus	206-210
10421786-3	1999	However, disruption of a membrane-proximal proline-rich sequence motif ("box1") in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3, but also IL-4-triggered activation of STAT5 and concomitant cell proliferation.	Proline	43-50	interleukin 4	Mus musculus	115-119
10421786-3	1999	However, disruption of a membrane-proximal proline-rich sequence motif ("box1") in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3, but also IL-4-triggered activation of STAT5 and concomitant cell proliferation.	Proline	43-50	signal transducer and activator of transcription 5A	Mus musculus	250-255
10490782-10	1999	In addition, individuals found to simultaneously exhibit homozygosity of the common allele of all three polymorphisms (genotypes: Arg/Arg, pro/pro and II/II) exhibited significantly elevated fasting insulin levels (Pc = 0.03).	Proline	143-146	insulin	Homo sapiens	199-206
10404387-0	1999	Monoclonal antibody specific to a subclass of polyproline-Arg motif provides evidence for the presence of an snRNA-free spliceosomal Sm protein complex in vivo: implications for molecular interactions involving proline-rich sequences of Sm B/B" proteins.	Proline	50-57	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	237-243
10413676-5	1999	Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required.	Proline	136-143	protein tyrosine kinase 2	Homo sapiens	22-25
10404387-8	1999	The Sm proline-rich sequences may have an important role in mediating protein-protein interactions necessary for the proper snRNP core assembly or function, or both.	Proline	7-14	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	124-129
10413676-5	1999	Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required.	Proline	136-143	protein tyrosine kinase 2	Homo sapiens	41-44
10425453-5	1999	Mutation of the two proline-rich domains of the PTTG protein has also been shown to abolish subsequent FGF induction.	Proline	20-27	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	48-52
10413676-5	1999	Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required.	Proline	136-143	protein tyrosine kinase 2	Homo sapiens	41-44
10447790-6	1999	The C1019-T mutation results in a proline to serine shift at codon 319 (cx37*1-cx37*2).	Proline	34-41	gap junction protein alpha 4	Homo sapiens	79-83
10413676-5	1999	Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required.	Proline	136-143	protein tyrosine kinase 2	Homo sapiens	41-44
10413676-5	1999	Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required.	Proline	136-143	protein tyrosine kinase 2	Homo sapiens	41-44
10413676-5	1999	Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required.	Proline	136-143	protein tyrosine kinase 2	Homo sapiens	41-44
10413676-5	1999	Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required.	Proline	136-143	protein tyrosine kinase 2	Homo sapiens	41-44
10447790-6	1999	The C1019-T mutation results in a proline to serine shift at codon 319 (cx37*1-cx37*2).	Proline	34-41	gap junction protein alpha 4	Homo sapiens	72-76
10447790-7	1999	A Restriction Fragment Length Polymorphism (RFLP) assay, involving the insertion of a novel Drd I cleavage site in the proline variant revealed a statistically significant over-representation of the cx37*1 allele in association with atherosclerotic plaque-bearing individuals (Odds-ratio for the homozygote = 2.38, Chi2 = 7.693, P = 0.006), in comparison to individuals lacking plaque, irrespective of a history of hypertension.	Proline	119-126	gap junction protein alpha 4	Homo sapiens	199-203
10477183-11	1999	OP-Tc preference for amino acids in the P2 position was (Gly,Lys,Arg) &gt; Phe &gt; Leu &gt; Pro.	Proline	93-96	opticin	Bos taurus	0-5
10414958-0	1999	L-proline and L-pipecolate induce enkephalin-sensitive currents in human embryonic kidney 293 cells transfected with the high-affinity mammalian brain L-proline transporter.	Proline	0-9	solute carrier family 6 member 7	Homo sapiens	151-172
10405347-1	1999	In search for selective agonists at human melanocortin-4 receptor, proline-substituted analogs of MTII, a potent nonselective agonist at melanocortin receptors, were prepared by solid-phase syntheses and evaluated for their ability to bind and activate human MC-3, MC-4, and MC-5 receptors.	Proline	67-74	metallothionein 2A	Homo sapiens	98-102
10527419-5	1999	The LRPKm1 region from +5 to +600 exhibits an alternative reading frame that encodes a product corresponding to a proline-rich protein fragment homologous to several hydroxyproline-rich proteins.	Proline	114-121	receptor-like protein kinase HSL1	Malus domestica	4-10
10409677-5	1999	The binding of VEGF-B(167) was mediated by the heparin binding domain, whereas the binding of VEGF-B(186) to NRP1 was regulated by exposure of a short COOH-terminal proline-rich peptide upon its proteolytic processing.	Proline	165-172	vascular endothelial growth factor B	Homo sapiens	94-100
10409677-5	1999	The binding of VEGF-B(167) was mediated by the heparin binding domain, whereas the binding of VEGF-B(186) to NRP1 was regulated by exposure of a short COOH-terminal proline-rich peptide upon its proteolytic processing.	Proline	165-172	neuropilin 1	Homo sapiens	109-113
10409712-4	1999	We had already identified a proline-rich binding determinant in the 21-kDa domain, the portion of 7B2 responsible for proPC2 activation.	Proline	28-35	secretogranin V	Rattus norvegicus	98-101
10400685-6	1999	We demonstrate that a proline-rich segment of PTP-PEST (Pro 2), 355PPEPHPVPPILTPSPPSAFP374, is essential for this interaction in vivo.	Proline	22-29	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	46-54
10400679-4	1999	The N-terminal region of p125 is rich in proline residues, and the central and C-terminal regions exhibit significant homology to phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1.	Proline	41-48	SEC23 interacting protein	Homo sapiens	25-29
10400685-7	1999	Furthermore, mutation of proline residues within the Pro 2 motif reveal that proline 362 is critical for the binding of paxillin.	Proline	25-32	paxillin	Homo sapiens	120-128
10400685-7	1999	Furthermore, mutation of proline residues within the Pro 2 motif reveal that proline 362 is critical for the binding of paxillin.	Proline	77-84	paxillin	Homo sapiens	120-128
10400685-10	1999	In conclusion, we show that a novel proline-rich motif found in PTP-PEST serves as a ligand for the LIM domains of paxillin.	Proline	36-43	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	64-72
10400685-10	1999	In conclusion, we show that a novel proline-rich motif found in PTP-PEST serves as a ligand for the LIM domains of paxillin.	Proline	36-43	paxillin	Homo sapiens	115-123
10395825-8	1999	Finally, the affinity of the proline-rich peptide GPPPQVPSRPNR, derived from dynamin, for the Grb2 N-SH3 domain was too low to be analyzed by NMR.	Proline	29-36	growth factor receptor bound protein 2	Homo sapiens	94-98
10393272-2	1999	The major function of these adaptors, such as Grb2, Nck, and Crk, is to recruit proline-rich effector molecules to tyrosine-phosphorylated kinases or their substrates.	Proline	80-87	growth factor receptor bound protein 2	Homo sapiens	46-50
10439036-11	1999	Efficient ubiquitin-mediated proteolysis of c-Mos requires proline as the second residue from the amino-terminus.	Proline	59-66	Moloney sarcoma oncogene	Mus musculus	44-49
10391914-8	1999	Mutated full-length p47(phox) with aspartic acid substitutions to mimic the effects of phosphorylations at serines 310 and 328 bind the p22(phox) proline-rich region in contrast to wild-type p47(phox).	Proline	146-153	pleckstrin	Homo sapiens	20-23
10393272-2	1999	The major function of these adaptors, such as Grb2, Nck, and Crk, is to recruit proline-rich effector molecules to tyrosine-phosphorylated kinases or their substrates.	Proline	80-87	NCK adaptor protein 1	Homo sapiens	52-55
10391914-8	1999	Mutated full-length p47(phox) with aspartic acid substitutions to mimic the effects of phosphorylations at serines 310 and 328 bind the p22(phox) proline-rich region in contrast to wild-type p47(phox).	Proline	146-153	pleckstrin	Homo sapiens	24-28
10391914-8	1999	Mutated full-length p47(phox) with aspartic acid substitutions to mimic the effects of phosphorylations at serines 310 and 328 bind the p22(phox) proline-rich region in contrast to wild-type p47(phox).	Proline	146-153	calcineurin like EF-hand protein 1	Homo sapiens	136-139
10393272-2	1999	The major function of these adaptors, such as Grb2, Nck, and Crk, is to recruit proline-rich effector molecules to tyrosine-phosphorylated kinases or their substrates.	Proline	80-87	CRK proto-oncogene, adaptor protein	Homo sapiens	61-64
10391914-8	1999	Mutated full-length p47(phox) with aspartic acid substitutions to mimic the effects of phosphorylations at serines 310 and 328 bind the p22(phox) proline-rich region in contrast to wild-type p47(phox).	Proline	146-153	pleckstrin	Homo sapiens	191-194
10383391-1	1999	The nuclear receptor mouse retinoid X receptor alpha (mRXRalpha) was shown to be constitutively phosphorylated in its NH2-terminal A/B region, which contains potential phosphorylation sites for proline-directed Ser/Thr kinases.	Proline	194-201	retinoid X receptor alpha	Mus musculus	27-52
10413115-2	1999	However, it has been claimed that GSK-3beta can also phosphorylate the non-proline-directed KXGS motifs in the presence of heparin, including Ser262 in the repeat domain of tau, which could induce the detachment of tau from microtubules.	Proline	75-82	glycogen synthase kinase 3 beta	Homo sapiens	34-43
10383467-7	1999	The repressive domain within ZF87/MAZ is located in the amino-terminal half of the protein, a region rich in proline and alanine residues.	Proline	109-116	MYC-associated zinc finger protein (purine-binding transcription factor)	Mus musculus	34-37
10413115-5	1999	We also show that the non-proline-directed activity at KXGS motifs is not due to GSK-3beta itself, but to kinase contaminations in common GSK-3beta preparations from tissues which are activated upon addition of heparin.	Proline	26-33	glycogen synthase kinase 3 beta	Homo sapiens	81-90
10388555-7	1999	Data from these studies indicated that induction of AP-1 by Nef is likely to be mediated through the MAPK (ERK1 and 2) signaling pathway and requires the proline-rich PxxP motif of Nef, suggesting the involvement of upstream protein kinases belonging to the Src family.	Proline	154-161	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-56
10388555-7	1999	Data from these studies indicated that induction of AP-1 by Nef is likely to be mediated through the MAPK (ERK1 and 2) signaling pathway and requires the proline-rich PxxP motif of Nef, suggesting the involvement of upstream protein kinases belonging to the Src family.	Proline	154-161	S100 calcium binding protein B	Homo sapiens	60-63
10413115-5	1999	We also show that the non-proline-directed activity at KXGS motifs is not due to GSK-3beta itself, but to kinase contaminations in common GSK-3beta preparations from tissues which are activated upon addition of heparin.	Proline	26-33	glycogen synthase kinase 3 beta	Homo sapiens	138-147
10388555-7	1999	Data from these studies indicated that induction of AP-1 by Nef is likely to be mediated through the MAPK (ERK1 and 2) signaling pathway and requires the proline-rich PxxP motif of Nef, suggesting the involvement of upstream protein kinases belonging to the Src family.	Proline	154-161	mitogen-activated protein kinase 3	Homo sapiens	101-105
10428197-1	1999	The protease catalyzing the hydrolysis of the tripeptide fluorescence substrate, butoxycarbonyl-valine-proline-arginine-(7-amino-4-methylcoumarin) (Boc-Val-Pro-Arg-MCA) and the neu oncogenic protein are potentially useful biomarkers for human cancer prevention studies.	Proline	103-110	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	177-180
10388555-7	1999	Data from these studies indicated that induction of AP-1 by Nef is likely to be mediated through the MAPK (ERK1 and 2) signaling pathway and requires the proline-rich PxxP motif of Nef, suggesting the involvement of upstream protein kinases belonging to the Src family.	Proline	154-161	mitogen-activated protein kinase 3	Homo sapiens	107-117
10388555-7	1999	Data from these studies indicated that induction of AP-1 by Nef is likely to be mediated through the MAPK (ERK1 and 2) signaling pathway and requires the proline-rich PxxP motif of Nef, suggesting the involvement of upstream protein kinases belonging to the Src family.	Proline	154-161	S100 calcium binding protein B	Homo sapiens	181-184
10388657-1	1999	We examined the effect of amino acid substitutions of the GPGR (glycine-proline-glycine-arginine) tip sequence at the V3 domain of the Env protein of human immunodeficiency virus type 1 (HIV-1) on its cell tropism and coreceptor use.	Proline	72-79	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	135-138
10408728-5	1999	It is worth noting that in a reporter gene inhibition assay, it was found that a neutralizing monoclonal antibody (MF1), the epitope for which is located between residues 190 and 197, had a high level of activity when cells (2060) harboring a gp46 with proline at position 192 were used and had no activity toward cells (1010) with a serine at this position.	Proline	253-260	flap structure-specific endonuclease 1	Homo sapiens	115-118
10428197-1	1999	The protease catalyzing the hydrolysis of the tripeptide fluorescence substrate, butoxycarbonyl-valine-proline-arginine-(7-amino-4-methylcoumarin) (Boc-Val-Pro-Arg-MCA) and the neu oncogenic protein are potentially useful biomarkers for human cancer prevention studies.	Proline	156-160	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	177-180
10498433-0	1999	Aromatic and basic residues within the EVH1 domain of VASP specify its interaction with proline-rich ligands.	Proline	88-95	vasodilator-stimulated phosphoprotein	Mus musculus	54-58
10373631-2	1999	The post proline cleaving substrate specificity makes DP IV relatively unique among other proteases.	Proline	9-16	dipeptidyl peptidase 4	Homo sapiens	54-59
10465520-7	1999	Tandem repeats of amino acids rich in serine, threonine and proline are a common element in mucin core proteins, giving rise to relatively rigid, linear molecules with great potential for glycosylation.	Proline	60-67	LOC100508689	Homo sapiens	92-97
10467005-4	1999	While Gap1p and Agp1p appear to be the main cysteine transporters on the non-repressing nitrogen source proline, Bap2p, Bap3p, Tat1p, Tat2p, Agp1p and Gnp1p are all important for cysteine uptake on ammonium-based medium.	Proline	104-111	amino acid permease GAP1	Saccharomyces cerevisiae S288C	6-11
10467005-4	1999	While Gap1p and Agp1p appear to be the main cysteine transporters on the non-repressing nitrogen source proline, Bap2p, Bap3p, Tat1p, Tat2p, Agp1p and Gnp1p are all important for cysteine uptake on ammonium-based medium.	Proline	104-111	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	16-21
10366564-4	1999	Nef binds to the adaptor proteins Bem1 and Ste20 via its proline-rich (PXXP) and diarginine (RR) motifs, respectively.	Proline	57-64	phosphatidylinositol-3-phosphate-binding protein BEM1	Saccharomyces cerevisiae S288C	34-38
10386957-7	1999	These results demonstrate that CDK-5 is a major proline-directed kinase phosphorylating the human NF-H tail domain.	Proline	48-55	cyclin dependent kinase 5	Homo sapiens	31-36
10386957-7	1999	These results demonstrate that CDK-5 is a major proline-directed kinase phosphorylating the human NF-H tail domain.	Proline	48-55	neurofilament heavy chain	Homo sapiens	98-102
10480384-7	1999	Once this problem was solved, we examined expression of the proline-rich cell wall proteins PRP1 and PRP2 in pigmented genotypes with the dominant T allele.	Proline	60-67	repetitive proline-rich cell wall protein 1	Glycine max	92-96
10381377-4	1999	Rat SHIP2 contains an amino-terminal SH2 domain, a central 5"-phosphoinositol phosphatase activity domain, and a phosphotyrosine binding (PTB) consensus sequence and a proline-rich region at the carboxyl tail.	Proline	168-175	inositol polyphosphate phosphatase-like 1	Rattus norvegicus	4-9
10395590-7	1999	Removal of arginine, proline, threonine, tryptophan or valine inhibited the stimulation of IGF-I expression that was induced by the combination of T3, DEX and GH (to 15, 6, 11, 16 and 16% of control, respectively, P &lt; 0.05), with significant decreases in GHR expression also observed in some cases.	Proline	21-28	insulin like growth factor 1	Sus scrofa	91-96
10395590-8	1999	The stimulatory effect of some of these amino acids (arginine, proline, threonine and tryptophan) was dose-dependent for expression of class 1 transcripts of IGF-I (P = 0.	Proline	63-70	insulin like growth factor 1	Sus scrofa	158-163
10524772-1	1999	In order to illustrate the structural importance of proline-40 of cytochrome b5 (Cyt b5), the P40V mutant gene was constructed.	Proline	52-59	cytochrome b5 type A	Homo sapiens	66-79
10524772-1	1999	In order to illustrate the structural importance of proline-40 of cytochrome b5 (Cyt b5), the P40V mutant gene was constructed.	Proline	52-59	cytochrome b5 type A	Homo sapiens	81-87
10404223-1	1999	T cell activation through the CD2 cell surface receptor is transmitted by proline-rich sequences within its cytoplasmic tail.	Proline	74-81	CD2 molecule	Homo sapiens	30-33
10404223-2	1999	A membrane-proximal proline-rich tandem repeat, involved in cytokine production, is recognized by the intracellular CD2 binding protein CD2BP2.	Proline	20-27	CD2 molecule	Homo sapiens	116-119
10404223-2	1999	A membrane-proximal proline-rich tandem repeat, involved in cytokine production, is recognized by the intracellular CD2 binding protein CD2BP2.	Proline	20-27	CD2 cytoplasmic tail binding protein 2	Homo sapiens	136-142
10364202-0	1999	D-site binding protein transactivation requires the proline- and acid-rich domain and involves the coactivator p300.	Proline	52-59	D-box binding PAR bZIP transcription factor	Homo sapiens	0-22
10364202-1	1999	The D-site binding protein (DBP) is a member of the proline- and acid-rich (PAR) domain subfamily of basic/leucine zipper proteins and is involved in transcriptional regulation in the liver.	Proline	52-59	D-box binding PAR bZIP transcription factor	Homo sapiens	4-26
10364202-1	1999	The D-site binding protein (DBP) is a member of the proline- and acid-rich (PAR) domain subfamily of basic/leucine zipper proteins and is involved in transcriptional regulation in the liver.	Proline	52-59	D-box binding PAR bZIP transcription factor	Homo sapiens	28-31
10374816-6	1999	The results show that the compound with N-terminal proline and C-terminal lysine amide exhibits cortistatin-like biological activities, including reduction of population spike amplitudes in the hippocampal CA1 region, decrease in locomotor activity and enhancement of slow-wave sleep 2.	Proline	51-58	cortistatin	Homo sapiens	96-107
10374816-7	1999	These findings suggest that both proline and lysine are necessary for cortistatin binding to its specific receptor.	Proline	33-40	cortistatin	Homo sapiens	70-81
10362357-3	1999	The protein lacks the extensive proline rich domain and leucine zipper seen in c-cbl and cbl-b and structurally most resembles the C. elegans and Drosophila cbl proteins.	Proline	32-39	Cbl proto-oncogene	Drosophila melanogaster	89-92
10360762-4	1999	Mutational analysis of the tau coding region identified a C-to-T change in exon 10 that resulted in the conversion of proline to a leucine (P301L) that segregated with frontotemporal dementia in this family.	Proline	118-125	microtubule associated protein tau	Homo sapiens	27-30
10353900-7	1999	Su(dx) belongs to a family of E3 ubiquitin ligase proteins containing membrane-targeting C2 domains and WW domains that mediate protein-protein interactions through recognition of proline-rich peptide sequences.	Proline	180-187	Suppressor of deltex	Drosophila melanogaster	0-6
10354417-0	1999	The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctions.	Proline	24-31	gap junction protein beta 1	Homo sapiens	110-114
10354417-1	1999	We have explored the role of a proline residue located at position 87 in the second transmembrane segment (TM2) of gap junctions in the mechanism of voltage-dependent gating of connexin32 (Cx32).	Proline	31-38	gap junction protein beta 1	Homo sapiens	177-187
10354417-1	1999	We have explored the role of a proline residue located at position 87 in the second transmembrane segment (TM2) of gap junctions in the mechanism of voltage-dependent gating of connexin32 (Cx32).	Proline	31-38	gap junction protein beta 1	Homo sapiens	189-193
10357818-3	1999	We demonstrate here that a third region encompassing a proline rich sequence within the 33 bp repetitive stretch of LMP1"s C-terminus is required for the activation of Janus kinase 3 (JAK3).	Proline	55-62	PDZ and LIM domain 7	Homo sapiens	116-120
10357818-3	1999	We demonstrate here that a third region encompassing a proline rich sequence within the 33 bp repetitive stretch of LMP1"s C-terminus is required for the activation of Janus kinase 3 (JAK3).	Proline	55-62	Janus kinase 3	Homo sapiens	168-182
10357818-3	1999	We demonstrate here that a third region encompassing a proline rich sequence within the 33 bp repetitive stretch of LMP1"s C-terminus is required for the activation of Janus kinase 3 (JAK3).	Proline	55-62	Janus kinase 3	Homo sapiens	184-188
10347180-4	1999	The yeast two-hybrid and in vitro binding analyses revealed that necdin bound to a narrow region (amino acids 35-62) located between the MDM2-binding site and the proline-rich region in the amino-terminal domain of p53.	Proline	163-170	necdin, MAGE family member	Homo sapiens	65-71
10347180-4	1999	The yeast two-hybrid and in vitro binding analyses revealed that necdin bound to a narrow region (amino acids 35-62) located between the MDM2-binding site and the proline-rich region in the amino-terminal domain of p53.	Proline	163-170	tumor protein p53	Homo sapiens	215-218
10421845-0	1999	Critical role of the membrane-proximal, proline-rich motif of the interleukin-2 receptor gammac chain in the Jak3-independent signal transduction.	Proline	40-47	interleukin 2 receptor subunit alpha	Homo sapiens	66-88
10451808-1	1999	Prolidase [EC 3.4.13.9] plays an important role in the recycling of proline for collagen synthesis and cell growth.	Proline	68-75	peptidase D	Homo sapiens	0-9
10421845-0	1999	Critical role of the membrane-proximal, proline-rich motif of the interleukin-2 receptor gammac chain in the Jak3-independent signal transduction.	Proline	40-47	Janus kinase 3	Homo sapiens	109-113
10332026-10	1999	A proline-rich region near the polyglutamine tract of the DRPLA protein and the SH3 domain of IRSp53 were involved in the binding.	Proline	2-9	BAR/IMD domain containing adaptor protein 2	Homo sapiens	94-100
10332029-3	1999	PQBP-1 has several functional domains, including hepta- and di-amino acid repeat sequences rich in polar residues essential for its interaction with the polyglutamine tract, a WWP/WW domain which binds to proline-rich motifs in other proteins, a putative nuclear localization signal sequence and a C2domain implicated in Ca2+-dependent phospholipid signaling.	Proline	205-212	polyglutamine binding protein 1	Rattus norvegicus	0-6
10404311-3	1999	RESULTS: A novel point mutation substituting a proline residue (CCG) for a leucine residue (CTG) was observed in codon 892 of exon 8 in the hormone-binding domain of the androgen receptor gene.	Proline	47-54	androgen receptor	Homo sapiens	170-187
10233929-0	1999	Proline residues in human immunodeficiency virus type 1 p6(Gag) exert a cell type-dependent effect on viral replication and virion incorporation of Pol proteins.	Proline	0-7	Pr55(Gag)	Human immunodeficiency virus 1	59-62
10395349-3	1999	There are two genetic polymorphisms in the DNA sequence encoding the leader sequence of the TGF-beta1 protein, located at codon 10 (either leucine or proline) and at codon 25 (either arginine or proline).	Proline	150-157	transforming growth factor beta 1	Homo sapiens	92-101
10395349-3	1999	There are two genetic polymorphisms in the DNA sequence encoding the leader sequence of the TGF-beta1 protein, located at codon 10 (either leucine or proline) and at codon 25 (either arginine or proline).	Proline	195-202	transforming growth factor beta 1	Homo sapiens	92-101
10233929-1	1999	The C terminus of the HIV-1 Gag protein contains a proline-rich domain termed p6(Gag).	Proline	51-58	Pr55(Gag)	Human immunodeficiency virus 1	28-31
10233929-1	1999	The C terminus of the HIV-1 Gag protein contains a proline-rich domain termed p6(Gag).	Proline	51-58	Pr55(Gag)	Human immunodeficiency virus 1	81-84
10233929-10	1999	Taken together, these data suggest that the proline-rich motif of p6(Gag) is involved in the late stages of virus maturation, which include the packaging of cleaved Pol proteins in viral particles, a process which may involve cell-type-specific factors.	Proline	44-51	Pr55(Gag)	Human immunodeficiency virus 1	69-72
10338211-3	1999	The crystal structure of the mammalian Enabled (Mena) EVH1 domain complexed with a peptide ligand reveals a mechanism of recognition distinct from that used by other proline-binding modules.	Proline	166-173	ENAH actin regulator	Homo sapiens	48-52
10483121-8	1999	The deduced amino acid sequence of PDF1 shares no significant homology with that of other known proteins but contains a putative signal peptide and novel proline-rich repeat motifs, suggesting a cell-wall protein.	Proline	154-161	protodermal factor 1	Arabidopsis thaliana	35-39
10336483-3	1999	In this study, we identify a CaM-KK from Caenorhabditis elegans, and comparison of its sequence with the mammalian CaM-KK alpha and beta shows a unique Arg-Pro (RP)-rich insert in their catalytic domains relative to other protein kinases.	Proline	156-159	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	29-35
10336483-3	1999	In this study, we identify a CaM-KK from Caenorhabditis elegans, and comparison of its sequence with the mammalian CaM-KK alpha and beta shows a unique Arg-Pro (RP)-rich insert in their catalytic domains relative to other protein kinases.	Proline	156-159	calcium/calmodulin dependent protein kinase kinase 1	Homo sapiens	115-127
10329181-1	1999	The PutR protein of Agrobacterium tumefaciens positively regulates expression of the putA gene in response to exogenous proline, resulting in the utilization of proline as a source of carbon and nitrogen.	Proline	120-127	putA	Agrobacterium tumefaciens	85-89
10329181-1	1999	The PutR protein of Agrobacterium tumefaciens positively regulates expression of the putA gene in response to exogenous proline, resulting in the utilization of proline as a source of carbon and nitrogen.	Proline	161-168	putA	Agrobacterium tumefaciens	85-89
10329181-4	1999	PutR also activated the putA promoter in vitro in the presence of proline, though less strongly than in whole cells.	Proline	66-73	putA	Agrobacterium tumefaciens	24-28
10350616-7	1999	The observed stability of beta-turns and some side chains in alphas1-casein(136-196) supports previous assumptions that hydrophobic, proline-based turns are important interaction sites in the self-association of alphas1-casein, and possibly in the formation of the calcium transport complexes, the casein micelles.	Proline	133-140	casein alpha s1	Homo sapiens	61-75
10350616-7	1999	The observed stability of beta-turns and some side chains in alphas1-casein(136-196) supports previous assumptions that hydrophobic, proline-based turns are important interaction sites in the self-association of alphas1-casein, and possibly in the formation of the calcium transport complexes, the casein micelles.	Proline	133-140	casein alpha s1	Homo sapiens	212-226
11230806-3	1999	Rainbow trout ARNT(b) (rtARNT(b)) contains a C-terminal domain rich in glutamine and asparagine (QN), whereas the C-terminal domain of rtARNT(a) is rich in proline, serine, and threonine (PST).	Proline	156-163	aryl hydrocarbon receptor nuclear translocator	Oncorhynchus mykiss	135-141
10365910-8	1999	Functional analysis showed that the proline 18/isoleucine 51 p16INK4a variant was diminished in cdk6 binding, cdk6 inhibition and NIH/3T3 fibroblast growth suppression compared with the histidine 18/valine 51 variant, whereas both of the p19ARF variants suppressed growth with similar potencies.	Proline	36-43	cyclin dependent kinase inhibitor 2A	Mus musculus	61-69
10365910-8	1999	Functional analysis showed that the proline 18/isoleucine 51 p16INK4a variant was diminished in cdk6 binding, cdk6 inhibition and NIH/3T3 fibroblast growth suppression compared with the histidine 18/valine 51 variant, whereas both of the p19ARF variants suppressed growth with similar potencies.	Proline	36-43	cyclin-dependent kinase 6	Mus musculus	96-100
10365910-8	1999	Functional analysis showed that the proline 18/isoleucine 51 p16INK4a variant was diminished in cdk6 binding, cdk6 inhibition and NIH/3T3 fibroblast growth suppression compared with the histidine 18/valine 51 variant, whereas both of the p19ARF variants suppressed growth with similar potencies.	Proline	36-43	cyclin-dependent kinase 6	Mus musculus	110-114
10365910-8	1999	Functional analysis showed that the proline 18/isoleucine 51 p16INK4a variant was diminished in cdk6 binding, cdk6 inhibition and NIH/3T3 fibroblast growth suppression compared with the histidine 18/valine 51 variant, whereas both of the p19ARF variants suppressed growth with similar potencies.	Proline	36-43	cyclin dependent kinase inhibitor 2A	Mus musculus	238-244
10336439-9	1999	Cells expressing beta1A with mutations of prolines or tyrosines in conserved cytoplasmic NPXY motifs had blunted migratory responses to mixtures of LPA and EGF or PDGF.	Proline	42-50	epidermal growth factor	Mus musculus	156-159
10421436-8	1999	ColQ contains a short peptidic motif, the proline-rich attachment domain (PRAD), that triggers the formation of AChE(T) tetramers, from monomers and dimers.	Proline	42-49	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	0-4
10421436-8	1999	ColQ contains a short peptidic motif, the proline-rich attachment domain (PRAD), that triggers the formation of AChE(T) tetramers, from monomers and dimers.	Proline	42-49	acetylcholinesterase (Cartwright blood group)	Homo sapiens	112-116
10329538-2	1999	Moreover, it has been reported that a proline-rich (PxxP) motif and an Arg-Arg (RR) motif in HIV-1 Nef bind to the SH3 domain of the Src-family tyrosine kinase Hck and to a serine/threonine kinase, respectively.	Proline	38-45	Nef	Human immunodeficiency virus 1	99-102
10329393-2	1999	Smad proteins of different species contain conserved amino- (N) and carboxy- (C) terminal domains separated by a proline-rich linker.	Proline	113-120	SMAD family member 1	Homo sapiens	0-4
10224104-1	1999	In eukaryotes, two isozymes (I and II) of methionine aminopeptidase (MetAP) catalyze the removal of the initiator methionine if the penultimate residue has a small radius of gyration (glycine, alanine, serine, threonine, proline, valine, and cysteine).	Proline	221-228	methionine aminopeptidase	Saccharomyces cerevisiae S288C	42-67
10224104-1	1999	In eukaryotes, two isozymes (I and II) of methionine aminopeptidase (MetAP) catalyze the removal of the initiator methionine if the penultimate residue has a small radius of gyration (glycine, alanine, serine, threonine, proline, valine, and cysteine).	Proline	221-228	methionine aminopeptidase	Saccharomyces cerevisiae S288C	69-74
10225955-2	1999	Afadin has one PDZ domain, three proline-rich regions, and one actin filament-binding domain.	Proline	33-40	afadin, adherens junction formation factor	Homo sapiens	0-6
11252182-1	1999	The Suppressor of fused [Su(fu)] gene of Drosophila melanogaster encodes a protein containing a PEST sequence [sequence enriched in proline (P), glutamic acid (E), serine (S) and threonine (T)] which acts as an antagonist to the serine-threonine kinase Fused in Hedgehog (Hh) signal transduction during embryogenesis.	Proline	132-139	Suppressor of fused	Drosophila melanogaster	25-31
10359089-4	1999	ProT2-mediated [1-14C]GABA transport was inhibited by proline and quaternary ammonium compounds.	Proline	54-61	proline transporter 2	Arabidopsis thaliana	0-5
10332684-1	1999	OBJECTIVE: To quantitate the contribution of postprandial blood glucose, which improves with the short-acting insulin analog lispro [Lys(B28),Pro(B29)] in type 1 diabetes, to the overall 24-h blood glucose concentration and the long-term HbA1c concentration under conditions of different postabsorptive blood glucose.	Proline	142-145	insulin	Homo sapiens	110-117
10194416-1	1999	Addition of ammonium ions to yeast cells growing on proline as the sole nitrogen source induces internalization of the general amino acid permease Gap1p and its subsequent degradation in the vacuole.	Proline	52-59	amino acid permease GAP1	Saccharomyces cerevisiae S288C	147-152
10224248-10	1999	Sequence analysis of grs1-1 in the mutant strain revealed that nucleotides 1656 and 1657 were both C to T transitions, resulting in a single amino acid change of proline to phenylalanine.	Proline	162-169	glycine--tRNA ligase	Saccharomyces cerevisiae S288C	21-25
10194416-7	1999	In proline-grown wild-type and npi2/doa4 cells overproducing ubiquitin, Gap1p appears to be mono-ubiquitinated at two lysine acceptor sites.	Proline	3-10	ubiquitin	Saccharomyces cerevisiae S288C	61-70
10194416-7	1999	In proline-grown wild-type and npi2/doa4 cells overproducing ubiquitin, Gap1p appears to be mono-ubiquitinated at two lysine acceptor sites.	Proline	3-10	amino acid permease GAP1	Saccharomyces cerevisiae S288C	72-77
10226945-3	1999	One tumor sample (case 23) showed a mis-sense point mutation at codon 177, changing CCC to CTC, which resulted in a substitution of proline to leucine in the p53 protein.	Proline	132-139	tumor protein p53	Homo sapiens	158-161
10413323-2	1999	Many of the phosphorylation sites on tau are serine/threonine-proline sequences, several of which are phosphorylated in vitro by neuronal Cdc2-like kinase (Nclk), a kinase composed of Cdk5 and its activator(s).	Proline	62-69	microtubule associated protein tau	Homo sapiens	37-40
10413323-2	1999	Many of the phosphorylation sites on tau are serine/threonine-proline sequences, several of which are phosphorylated in vitro by neuronal Cdc2-like kinase (Nclk), a kinase composed of Cdk5 and its activator(s).	Proline	62-69	cyclin dependent kinase 5	Homo sapiens	184-188
10196196-0	1999	SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.	Proline	43-50	Spi-B transcription factor (Spi-1/PU.1 related)	Mus musculus	0-5
10212202-3	1999	The SH3 domain and the first proline-rich motif bound each other, and variants of p85 containing the SH3 and BH domains and the first proline-rich motif were dimeric.	Proline	29-36	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	82-85
10212202-3	1999	The SH3 domain and the first proline-rich motif bound each other, and variants of p85 containing the SH3 and BH domains and the first proline-rich motif were dimeric.	Proline	134-141	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	82-85
10207045-1	1999	TESK1 (testis-specific protein kinase 1) is a protein kinase with a structure composed of an N-terminal protein kinase domain and a C-terminal proline-rich domain.	Proline	143-150	testis associated actin remodelling kinase 1	Homo sapiens	0-5
10207045-1	1999	TESK1 (testis-specific protein kinase 1) is a protein kinase with a structure composed of an N-terminal protein kinase domain and a C-terminal proline-rich domain.	Proline	143-150	testis associated actin remodelling kinase 1	Homo sapiens	7-39
10209040-2	1999	We show here that BCR/ABL induces phosphorylation and activation of STAT5 by a mechanism that requires the BCR/ABL Src homology (SH)2 domain and the proline-rich binding site of the SH3 domain.	Proline	149-156	BCR activator of RhoGEF and GTPase	Mus musculus	18-25
10209040-2	1999	We show here that BCR/ABL induces phosphorylation and activation of STAT5 by a mechanism that requires the BCR/ABL Src homology (SH)2 domain and the proline-rich binding site of the SH3 domain.	Proline	149-156	signal transducer and activator of transcription 5A	Mus musculus	68-73
10209040-2	1999	We show here that BCR/ABL induces phosphorylation and activation of STAT5 by a mechanism that requires the BCR/ABL Src homology (SH)2 domain and the proline-rich binding site of the SH3 domain.	Proline	149-156	BCR activator of RhoGEF and GTPase	Mus musculus	18-21
10209040-2	1999	We show here that BCR/ABL induces phosphorylation and activation of STAT5 by a mechanism that requires the BCR/ABL Src homology (SH)2 domain and the proline-rich binding site of the SH3 domain.	Proline	149-156	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	22-25
10209040-2	1999	We show here that BCR/ABL induces phosphorylation and activation of STAT5 by a mechanism that requires the BCR/ABL Src homology (SH)2 domain and the proline-rich binding site of the SH3 domain.	Proline	149-156	sperm hammerhead 3	Mus musculus	182-185
10209041-4	1999	Expression of GrpL is restricted to hematopoietic tissues, and it is distinguished from Grb2 by having a proline-rich region.	Proline	105-112	GRB2 related adaptor protein 2	Homo sapiens	14-18
10222231-3	1999	The Ncd tail domain shares many properties with the microtubule-associated proteins that regulate microtubule assembly, including microtubule binding and bundling activity and an abundance of basic and proline residues.	Proline	202-209	non-claret disjunctional	Drosophila melanogaster	4-7
10206953-2	1999	Here we report that the mutation of these residues in Kv1.1 to leucine, proline, or arginine abolished the expression of outward potassium currents in Xenopus oocytes.	Proline	72-79	potassium channel, voltage gated shaker related subfamily A, member 1 S homeolog	Xenopus laevis	54-59
10202035-3	1999	Human eotaxin has a penultimate proline, indicating that it might be a substrate for dipeptidyl-peptidase IV (CD26/DPP IV).	Proline	32-39	C-C motif chemokine ligand 11	Homo sapiens	6-13
10202035-3	1999	Human eotaxin has a penultimate proline, indicating that it might be a substrate for dipeptidyl-peptidase IV (CD26/DPP IV).	Proline	32-39	dipeptidyl peptidase 4	Homo sapiens	85-108
10229204-4	1999	Further sequencing analyses of the p16INK4a gene exon 2 in 19 additional tumours with no evidence of LOH on 9p21-22 identified only one heterozygous C- &gt;T mutation at codon 81 altering a proline to a leucine.	Proline	190-197	cyclin dependent kinase inhibitor 2A	Homo sapiens	35-43
10092647-9	1999	The amino acid sequence encoded by exon 8 of the human iPLA2 gene is proline-rich and shares a consensus motif of PX5PX8HHPX12NX4Q with the proline-rich middle linker domains of the Smad proteins DAF-3 and Smad4.	Proline	69-76	phospholipase A2 group VI	Homo sapiens	55-60
10187839-0	1999	Proline-rich motifs of the Na+/H+ exchanger 2 isoform.	Proline	0-7	solute carrier family 9 member A2	Sus scrofa	27-43
10187839-2	1999	The NHE2 isoform of the Na+/H+ exchanger (NHE) displays two proline-rich sequences in its C-terminal region that resemble SH3 (Src homology 3)-binding domains.	Proline	60-67	solute carrier family 9 member A2	Sus scrofa	4-8
10187839-2	1999	The NHE2 isoform of the Na+/H+ exchanger (NHE) displays two proline-rich sequences in its C-terminal region that resemble SH3 (Src homology 3)-binding domains.	Proline	60-67	solute carrier family 9 member A2	Sus scrofa	24-40
10187839-2	1999	The NHE2 isoform of the Na+/H+ exchanger (NHE) displays two proline-rich sequences in its C-terminal region that resemble SH3 (Src homology 3)-binding domains.	Proline	60-67	solute carrier family 9 member A2	Sus scrofa	4-7
10187783-2	1999	NSP1 has an Shc-related SH2 domain and a putative proline/serine-rich SH3 interaction domain.	Proline	50-57	SH2 domain containing 3A	Homo sapiens	0-4
10092676-6	1999	As for PTP-PEST, one of the five proline-rich sequences found on PTP-PEST, Pro-2, was identified as the binding site for Hic-5 in in vitro binding assays.	Proline	33-40	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	65-73
10092647-9	1999	The amino acid sequence encoded by exon 8 of the human iPLA2 gene is proline-rich and shares a consensus motif of PX5PX8HHPX12NX4Q with the proline-rich middle linker domains of the Smad proteins DAF-3 and Smad4.	Proline	140-147	phospholipase A2 group VI	Homo sapiens	55-60
10092676-6	1999	As for PTP-PEST, one of the five proline-rich sequences found on PTP-PEST, Pro-2, was identified as the binding site for Hic-5 in in vitro binding assays.	Proline	33-40	transforming growth factor beta 1 induced transcript 1	Homo sapiens	121-126
10092647-9	1999	The amino acid sequence encoded by exon 8 of the human iPLA2 gene is proline-rich and shares a consensus motif of PX5PX8HHPX12NX4Q with the proline-rich middle linker domains of the Smad proteins DAF-3 and Smad4.	Proline	140-147	SMAD family member 4	Homo sapiens	182-186
10072425-4	1999	The SYT protein has a novel conserved 54 amino acid domain at the N-terminus of the protein (the SNH domain) which is found in proteins from a wide variety of species, and a C-terminal domain, rich in glutamine, proline, glycine and tyrosine (the QPGY domain), which contains the transcriptional activator sequences.	Proline	212-219	SS18 subunit of BAF chromatin remodeling complex	Homo sapiens	4-7
10101215-3	1999	The following aspects of DPP IV/CD26 will be discussed : the structure of DPP IV and the new family of serine proteases to which it belongs, the substrate specificity, the distribution in the human body, specific DPP IV inhibitors and the role of CD26 in the intestinal and renal handling of proline containing peptides, in cell adhesion, in peptide metabolism, in the immune system and in HIV infection.	Proline	292-299	dipeptidyl peptidase 4	Homo sapiens	25-31
10101215-3	1999	The following aspects of DPP IV/CD26 will be discussed : the structure of DPP IV and the new family of serine proteases to which it belongs, the substrate specificity, the distribution in the human body, specific DPP IV inhibitors and the role of CD26 in the intestinal and renal handling of proline containing peptides, in cell adhesion, in peptide metabolism, in the immune system and in HIV infection.	Proline	292-299	dipeptidyl peptidase 4	Homo sapiens	32-36
10230647-0	1999	Role of proline 193 in the insulin receptor post-translational processing.	Proline	8-15	insulin receptor	Homo sapiens	27-43
10229072-1	1999	The Nck adaptor protein links tyrosine kinases or their substrates to proteins containing proline-rich motifs.	Proline	90-97	NCK adaptor protein 1	Homo sapiens	4-7
10363664-1	1999	BACKGROUND: It is reported that psychiatric disorders, such as depression and schizophrenia, are associated with changes in serum activity of prolyl endopeptidase (EC 3.4.21.26), a cytosolic endopeptidase, which cleaves peptide bonds on the carboxylside of proline in proteins of relatively small molecular mass.	Proline	257-264	prolyl endopeptidase	Homo sapiens	142-162
10097107-6	1999	A proline-rich domain in the middle of Scar enhances the activity of the W and A domains.	Proline	2-9	ribosomal protein S4 X-linked	Homo sapiens	39-43
10198015-10	1999	The S-layer and RTX domains of Csx are separated by a proline-rich stretch of 48 amino acids.	Proline	54-61	NK2 homeobox 5	Homo sapiens	31-34
10082583-5	1999	In addition, when the seven proline-directed sites in MyoD were individually mutated, only substitution of serine 200 to a nonphosphorylatable alanine (MyoD-Ala200) abolished the slower-migrating hyperphosphorylated form of MyoD, seen either in vitro after phosphorylation by cdk1-cyclin B or in vivo following overexpression in 10T1/2 cells.	Proline	28-35	myogenic differentiation 1	Mus musculus	54-58
10082583-5	1999	In addition, when the seven proline-directed sites in MyoD were individually mutated, only substitution of serine 200 to a nonphosphorylatable alanine (MyoD-Ala200) abolished the slower-migrating hyperphosphorylated form of MyoD, seen either in vitro after phosphorylation by cdk1-cyclin B or in vivo following overexpression in 10T1/2 cells.	Proline	28-35	myogenic differentiation 1	Mus musculus	152-156
10082583-5	1999	In addition, when the seven proline-directed sites in MyoD were individually mutated, only substitution of serine 200 to a nonphosphorylatable alanine (MyoD-Ala200) abolished the slower-migrating hyperphosphorylated form of MyoD, seen either in vitro after phosphorylation by cdk1-cyclin B or in vivo following overexpression in 10T1/2 cells.	Proline	28-35	myogenic differentiation 1	Mus musculus	152-156
10218629-6	1999	Sequencing of exon 10 of the tau gene revealed a C to T transition at codon 301, resulting in a Pro to Leu substitution.	Proline	96-99	microtubule associated protein tau	Homo sapiens	29-32
10082559-3	1999	Data accumulated thus far support a model whereby p70S6K activation requires sequential phosphorylations at proline-directed residues in the putative autoinhibitory pseudosubstrate domain, as well as threonine 389.	Proline	108-115	ribosomal protein S6 kinase B1	Homo sapiens	50-56
10222779-5	1999	A proline-rich region near polyglutamine of the DRPLA protein and the SH3 domain of IRSp53 were involved in the binding.	Proline	2-9	BAR/IMD domain containing adaptor protein 2	Homo sapiens	84-90
10090741-4	1999	The proline-directed kinases MAPK and GSK3 are known to phosphorylate most Ser-Pro or Thr-Pro motifs in the regions flanking the repeat domain of tau: they induce the reaction with several antibodies diagnostic of Alzheimer PHFs, but this type of phosphorylation has only a weak effect on tau-microtubule interactions and on PHF assembly.	Proline	79-82	microtubule associated protein tau	Homo sapiens	146-149
10452123-4	1999	RESULTS: Pretreatment of pulmonary VSMC with Cap 1 mumol.L-1 blocked hypoxia-induced increase in cell number and incorporation of [3H]proline and [3H]thymidine, which were decreased 25%, 21%, and 36%, respectively, as compared with hypoxic control.	Proline	134-141	adenylyl cyclase-associated protein 1	Oryctolagus cuniculus	45-50
10087267-4	1999	The EVH1 (Ena/VASP homology 1) domain of VASP is in slow association-dissociation equilibrium high-affinity binding to the zyxin-homologous, proline-rich region of ActA.	Proline	141-148	vasodilator-stimulated phosphoprotein	Mus musculus	14-18
10087267-4	1999	The EVH1 (Ena/VASP homology 1) domain of VASP is in slow association-dissociation equilibrium high-affinity binding to the zyxin-homologous, proline-rich region of ActA.	Proline	141-148	vasodilator-stimulated phosphoprotein	Mus musculus	41-45
10321740-2	1999	Several functional domains necessary for mediating cell cycle arrest and apoptosis in p53 have been mapped, e.g., the proline-rich domain.	Proline	118-125	tumor protein p53	Homo sapiens	86-89
10321740-5	1999	We found that p53(delta62-91), which lacks all five PXXP motifs in human p53, is capable of inducing cell cycle arrest but not apoptosis, while p53(gln22-ser23/delta62-91), which contains a double point mutation in the activation domain as well as deletion of the proline-rich domain, completely loses its activity.	Proline	264-271	tumor protein p53	Homo sapiens	14-17
10321740-10	1999	These results suggest that the proline-rich region may play a role in chromatin remodeling, which counteracts chromatin-mediated repression for some of the endogenous p53 target genes.	Proline	31-38	tumor protein p53	Homo sapiens	167-170
10090741-4	1999	The proline-directed kinases MAPK and GSK3 are known to phosphorylate most Ser-Pro or Thr-Pro motifs in the regions flanking the repeat domain of tau: they induce the reaction with several antibodies diagnostic of Alzheimer PHFs, but this type of phosphorylation has only a weak effect on tau-microtubule interactions and on PHF assembly.	Proline	90-93	microtubule associated protein tau	Homo sapiens	146-149
10090741-4	1999	The proline-directed kinases MAPK and GSK3 are known to phosphorylate most Ser-Pro or Thr-Pro motifs in the regions flanking the repeat domain of tau: they induce the reaction with several antibodies diagnostic of Alzheimer PHFs, but this type of phosphorylation has only a weak effect on tau-microtubule interactions and on PHF assembly.	Proline	90-93	microtubule associated protein tau	Homo sapiens	289-292
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	Proline	263-270	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-39
10077585-1	1999	A yeast mutant was isolated encoding a single amino acid substitution [serine-53 --&gt; proline (S53P)] in transcription factor TFIIB that impairs activation of the PHO5 gene in response to phosphate starvation.	Proline	88-95	acid phosphatase PHO5	Saccharomyces cerevisiae S288C	165-169
10077588-5	1999	This kinetic heterogeneity appears to be intrinsic to the diffusional nature of early folding dynamics on the energy landscape, as opposed to the late-time heterogeneity associated with nonnative heme ligation and proline isomers in cytochrome c.	Proline	214-221	cytochrome c, somatic	Homo sapiens	233-245
10037691-3	1999	IIABMan has two domains (IIA and IIB) that are linked by a 60-A long alanine-proline-rich linker.	Proline	77-84	colicin Ia immunity protein	Escherichia coli	0-3
10095061-7	1999	The encoded amino acid sequence predicts that the MEMA protein has three coiled-coil domains, one glycine loop domain, is very hydrophilic and contains regions rich in glutamine/proline, glutamic acid and serine residues.	Proline	178-185	pinin, desmosome associated protein	Homo sapiens	50-54
10075926-6	1999	Using mutational analysis we have identified a region of Jak3, including portions of JH6 and JH7, that is sufficient for kinase-receptor contact and show that this segment interacts with the proline-rich Box1 region of the receptor.	Proline	191-198	Janus kinase 3	Homo sapiens	57-61
10066823-5	1999	Our data indicate that the proline-rich region of HS1 bordered by tyrosyl residues affected by Syk and Src family kinases represents a functional domain designed to undergo a process of sequential phosphorylation.	Proline	27-34	hematopoietic cell-specific Lyn substrate 1	Homo sapiens	50-53
10066823-5	1999	Our data indicate that the proline-rich region of HS1 bordered by tyrosyl residues affected by Syk and Src family kinases represents a functional domain designed to undergo a process of sequential phosphorylation.	Proline	27-34	spleen associated tyrosine kinase	Homo sapiens	95-98
10066823-5	1999	Our data indicate that the proline-rich region of HS1 bordered by tyrosyl residues affected by Syk and Src family kinases represents a functional domain designed to undergo a process of sequential phosphorylation.	Proline	27-34	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	103-106
10085297-7	1999	The third proline-rich region of l-afadin bound to the region of ponsin containing the second and third SH3 domains.	Proline	10-17	afadin, adherens junction formation factor	Homo sapiens	35-41
10085297-7	1999	The third proline-rich region of l-afadin bound to the region of ponsin containing the second and third SH3 domains.	Proline	10-17	sorbin and SH3 domain containing 1	Homo sapiens	65-71
10085297-10	1999	Vinculin has one proline-rich region where two proline-rich sequences are located.	Proline	17-24	vinculin	Homo sapiens	0-8
10085297-10	1999	Vinculin has one proline-rich region where two proline-rich sequences are located.	Proline	47-54	vinculin	Homo sapiens	0-8
10085297-11	1999	The proline-rich region bound to the region of ponsin containing the first and second SH3 domains.	Proline	4-11	sorbin and SH3 domain containing 1	Homo sapiens	47-53
10051558-6	1999	The activity profiles obtained for thrombin also suggest that the conversion of Pro to Tyr or Phe documented in the vertebrates occurred through Ser and was driven by a significant gain (up to 50-fold) in catalytic activity.	Proline	80-83	coagulation factor II, thrombin	Homo sapiens	35-43
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	Proline	263-270	aldehyde dehydrogenase 18 family member A1	Homo sapiens	41-45
10037775-7	1999	To confirm the identity of the putative P5CS cDNAs, we expressed both human forms in gamma-glutamyl kinase- and gamma-glutamyl phosphate reductase-deficient strains of Saccharomyces cerevisiae and showed that they conferred the proline prototrophy.	Proline	228-235	aldehyde dehydrogenase 18 family member A1	Homo sapiens	40-44
10037775-8	1999	Additionally, we found expression of the murine putative P5CS cDNAs conferred proline prototrophy to P5CS-deficient Chinese hamster ovary cells (CHO-K1).	Proline	78-85	aldehyde dehydrogenase 18 family, member A1	Mus musculus	57-61
10100603-4	1999	We now describe a novel protein that includes (i) a so-called BRCT domain found in many proteins involved in DNA repair, (ii) an area that is homologous to the NAD-dependent catalytic domain of poly(ADP-ribose)polymerase, (iii) an area that is homologous to the upper two thirds of precursor polypeptides H1P-H4P and (iv) a proline-rich region with a potential nuclear localization signal.	Proline	324-331	poly(ADP-ribose) polymerase 1	Homo sapiens	194-220
12054111-7	1999	The carboxyl terminal domain of SOS contains a proline-rich regions that directs its association with the SH3 domains of the small adapter protein, Grb2.	Proline	47-54	xylosyltransferase 2	Homo sapiens	32-35
10223338-6	1999	There is a proline-rich region at the amino acid positions 373 to 377 of HIV-2 gag, and replacement of these proline residues by site-directed mutagenesis completely abolished VLP assembly.	Proline	11-18	Pr55(Gag)	Human immunodeficiency virus 1	79-82
10223338-6	1999	There is a proline-rich region at the amino acid positions 373 to 377 of HIV-2 gag, and replacement of these proline residues by site-directed mutagenesis completely abolished VLP assembly.	Proline	109-116	Pr55(Gag)	Human immunodeficiency virus 1	79-82
12054111-7	1999	The carboxyl terminal domain of SOS contains a proline-rich regions that directs its association with the SH3 domains of the small adapter protein, Grb2.	Proline	47-54	growth factor receptor bound protein 2	Homo sapiens	148-152
10202375-4	1999	MATERIALS AND METHODS: Apo A-I variants from heterozygous carriers of Lys-107--&gt;0, Lys-107--&gt;Met, Pro-3--&gt;Arg, Pro-4--&gt;Arg, Pro-165--&gt;Arg and Glu-198--&gt;Lys and the corresponding normal apo A-I were purified and then radioiodinated with 131I and 125I.	Proline	104-107	apolipoprotein A1	Homo sapiens	23-30
10092092-3	1999	Among the PTP cloned by reverse transcription-PCR, mRNA expression of the proline-, glutamic acid-, serine- and threonine-rich (PEST) domain phosphatase (PEP) was selectively elevated 3.1-fold within 3 h after anti-IgM antibody stimulation.	Proline	74-81	protein tyrosine phosphatase, receptor type, S	Mus musculus	10-13
10092092-3	1999	Among the PTP cloned by reverse transcription-PCR, mRNA expression of the proline-, glutamic acid-, serine- and threonine-rich (PEST) domain phosphatase (PEP) was selectively elevated 3.1-fold within 3 h after anti-IgM antibody stimulation.	Proline	74-81	prolyl endopeptidase	Mus musculus	154-157
10202375-4	1999	MATERIALS AND METHODS: Apo A-I variants from heterozygous carriers of Lys-107--&gt;0, Lys-107--&gt;Met, Pro-3--&gt;Arg, Pro-4--&gt;Arg, Pro-165--&gt;Arg and Glu-198--&gt;Lys and the corresponding normal apo A-I were purified and then radioiodinated with 131I and 125I.	Proline	120-123	apolipoprotein A1	Homo sapiens	23-30
10050048-10	1999	The co-localization of arginase II and the three ornithine-utilizing enzymes in the small intestine suggests that the enzyme is involved in the synthesis of proline, polyamines, and/or citrulline in this tissue.	Proline	157-164	arginase 2	Rattus norvegicus	23-34
10323252-9	1999	These studies demonstrate the importance of proline 183 for the proper structure/function of emerin.	Proline	44-51	emerin	Homo sapiens	93-99
10084598-3	1999	G319S is within the proline II-rich domain of the trans-activation site of HNF-1alpha and alters a glycine residue that is conserved throughout evolution.	Proline	20-27	HNF1 homeobox A	Homo sapiens	75-85
10022517-4	1999	The peptide sequence responsible for the interaction of BPAG2 was restricted to amino acids 15-25, and substitution of a valine residue in the middle of this sequence by a proline (V23P) by site-directed mutagenesis abolished the interaction.	Proline	172-179	collagen type XVII alpha 1 chain	Homo sapiens	56-61
9971776-0	1999	Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking.	Proline	151-158	S100 calcium binding protein B	Homo sapiens	0-3
10064737-10	1999	We conclude that amino acid residues arginine 160 and proline 165 of apoA-I contribute to the formation of a domain that is very important for initial lipid binding and contributes to LCAT-activation and promotion of initial cholesterol efflux but not to the stabilization of preformed rLpA-I.	Proline	54-61	apolipoprotein A-I	Mus musculus	69-75
9971776-0	1999	Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking.	Proline	151-158	S100 calcium binding protein B	Homo sapiens	169-172
10064737-10	1999	We conclude that amino acid residues arginine 160 and proline 165 of apoA-I contribute to the formation of a domain that is very important for initial lipid binding and contributes to LCAT-activation and promotion of initial cholesterol efflux but not to the stabilization of preformed rLpA-I.	Proline	54-61	lecithin cholesterol acyltransferase	Mus musculus	184-188
9971776-8	1999	Although both the N-terminal alpha-helix and the proline-rich region of Nef have been implicated in recruiting Src family protein kinases, the inhibitor herbimycin A did not block MHC-I down-regulation, suggesting that the latter process is not mediated through an activation of this family of tyrosine kinases.	Proline	49-56	S100 calcium binding protein B	Homo sapiens	72-75
9971776-0	1999	Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking.	Proline	151-158	CD4 molecule	Homo sapiens	12-15
10022920-3	1999	Pap is a multidomain protein composed of an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal SH3 domain.	Proline	193-200	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	Homo sapiens	0-3
10194128-2	1999	The amino terminal CRKL SH3 domain binds directly to a proline-rich region in the C-terminus of BCR-ABL.	Proline	55-62	CRK like proto-oncogene, adaptor protein	Homo sapiens	19-23
10194128-2	1999	The amino terminal CRKL SH3 domain binds directly to a proline-rich region in the C-terminus of BCR-ABL.	Proline	55-62	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	96-103
10194128-4	1999	Yeast two-hybrid analysis and gel overlay assays show eradication of the direct interaction of CRKL with BCR-ABL in the proline deletion mutants.	Proline	120-127	CRK like proto-oncogene, adaptor protein	Homo sapiens	95-99
10194128-4	1999	Yeast two-hybrid analysis and gel overlay assays show eradication of the direct interaction of CRKL with BCR-ABL in the proline deletion mutants.	Proline	120-127	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	105-112
10199158-1	1999	Two rapid-acting insulin analogues, Lys(B28), Pro(B29)-human insulin (insulin lispro) and Asp(B28)-human insulin (insulin aspart) are developed and introduced into the clinical trials or applications recently.	Proline	46-49	insulin	Homo sapiens	17-24
10199602-8	1999	Compared to the vehicle treatment, glycine-proline-glutamate (n=19) treatment reduced the extent of cortical damage and neuronal loss in the CA1-2 subregions of the hippocampus (P&lt;0.05).	Proline	43-50	carbonic anhydrase 1	Rattus norvegicus	141-144
10199158-1	1999	Two rapid-acting insulin analogues, Lys(B28), Pro(B29)-human insulin (insulin lispro) and Asp(B28)-human insulin (insulin aspart) are developed and introduced into the clinical trials or applications recently.	Proline	46-49	insulin	Homo sapiens	61-68
10199158-1	1999	Two rapid-acting insulin analogues, Lys(B28), Pro(B29)-human insulin (insulin lispro) and Asp(B28)-human insulin (insulin aspart) are developed and introduced into the clinical trials or applications recently.	Proline	46-49	insulin	Homo sapiens	61-68
10199158-1	1999	Two rapid-acting insulin analogues, Lys(B28), Pro(B29)-human insulin (insulin lispro) and Asp(B28)-human insulin (insulin aspart) are developed and introduced into the clinical trials or applications recently.	Proline	46-49	insulin	Homo sapiens	61-68
10199158-3	1999	Proline at position B28 near the COOH terminal of the B chain of human insulin is important for the dimerization of insulin molecules.	Proline	0-7	insulin	Homo sapiens	71-78
10199158-3	1999	Proline at position B28 near the COOH terminal of the B chain of human insulin is important for the dimerization of insulin molecules.	Proline	0-7	insulin	Homo sapiens	116-123
9931304-6	1999	In the present work, Thr233 has been identified as the major phosphorylation site of p67phox, which is situated in a proline-rich domain.	Proline	117-124	neutrophil cytosolic factor 2	Homo sapiens	85-92
10072398-0	1999	LeProT1, a transporter for proline, glycine betaine, and gamma-amino butyric acid in tomato pollen.	Proline	27-34	proline transporter 1	Solanum lycopersicum	0-7
10072398-8	1999	Expression in a yeast mutant demonstrated that LeProT1 transports proline and gamma-amino butyric acid with low affinity and glycine betaine with high affinity.	Proline	66-73	proline transporter 1	Solanum lycopersicum	47-54
10228387-8	1999	We also operated in-source fragmentation (MSMSMS; MS3) technique using a proline fragment or [M + 14H]14+ of intact normal and variant beta globin and confirmed the sequence of amino acids of variant Hbs.	Proline	73-80	MS3	Homo sapiens	50-53
10022120-1	1999	Cbl-b, a mammalian homolog of Cbl, consists of an N-terminal region (Cbl-b-N) highly homologous to oncogenic v-Cbl, a Ring finger, and a C-terminal region containing multiple proline-rich stretches and potential tyrosine phosphorylation sites.	Proline	175-182	Cbl proto-oncogene B	Homo sapiens	0-5
9933620-4	1999	The ordered kallikrein loop projects proline toward the active site to restrict smaller residues or proline at the P2 position of substrates.	Proline	37-44	kallikrein 1-related peptidase b9	Mus musculus	12-22
9933620-4	1999	The ordered kallikrein loop projects proline toward the active site to restrict smaller residues or proline at the P2 position of substrates.	Proline	100-107	kallikrein 1-related peptidase b9	Mus musculus	12-22
10022120-1	1999	Cbl-b, a mammalian homolog of Cbl, consists of an N-terminal region (Cbl-b-N) highly homologous to oncogenic v-Cbl, a Ring finger, and a C-terminal region containing multiple proline-rich stretches and potential tyrosine phosphorylation sites.	Proline	175-182	Cbl proto-oncogene	Homo sapiens	0-3
10022120-1	1999	Cbl-b, a mammalian homolog of Cbl, consists of an N-terminal region (Cbl-b-N) highly homologous to oncogenic v-Cbl, a Ring finger, and a C-terminal region containing multiple proline-rich stretches and potential tyrosine phosphorylation sites.	Proline	175-182	Cbl proto-oncogene	Homo sapiens	30-33
9920849-7	1999	Lastly, mutation of a proline motif in the core region of the nef gene, which disrupts its ability to interact with cellular kinases and reduces HIV-1 replication in vitro, completely abrogated the Nef-mediated induction of apoptosis as well as its ability to upregulate surface CD95 and CD95L.	Proline	22-29	Nef	Human immunodeficiency virus 1	62-65
9920849-7	1999	Lastly, mutation of a proline motif in the core region of the nef gene, which disrupts its ability to interact with cellular kinases and reduces HIV-1 replication in vitro, completely abrogated the Nef-mediated induction of apoptosis as well as its ability to upregulate surface CD95 and CD95L.	Proline	22-29	Nef	Human immunodeficiency virus 1	198-201
9920849-7	1999	Lastly, mutation of a proline motif in the core region of the nef gene, which disrupts its ability to interact with cellular kinases and reduces HIV-1 replication in vitro, completely abrogated the Nef-mediated induction of apoptosis as well as its ability to upregulate surface CD95 and CD95L.	Proline	22-29	Fas cell surface death receptor	Homo sapiens	279-283
9920849-7	1999	Lastly, mutation of a proline motif in the core region of the nef gene, which disrupts its ability to interact with cellular kinases and reduces HIV-1 replication in vitro, completely abrogated the Nef-mediated induction of apoptosis as well as its ability to upregulate surface CD95 and CD95L.	Proline	22-29	Fas ligand	Homo sapiens	288-293
10400475-7	1999	The second is prolyl-tRNA synthetase, complexed with its cognate tRNA, that has to specifically recognise the two guanines common to all tRNA anticodons specific for proline.	Proline	166-173	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	14-36
10092885-0	1999	Site-directed mutagenesis of proline 204 in the "hinge" region of yeast phosphoglycerate kinase.	Proline	29-36	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	72-95
10092885-1	1999	Site-specific mutants have been produced in order to investigate the role of proline 204 in the "hinge" region of yeast phosphoglycerate kinase (PGK).	Proline	77-84	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	120-143
10092885-1	1999	Site-specific mutants have been produced in order to investigate the role of proline 204 in the "hinge" region of yeast phosphoglycerate kinase (PGK).	Proline	77-84	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	145-148
10092885-2	1999	This totally conserved proline has been shown to be the only cis-proline in the high resolution crystal structures of yeast, B. stearothermophilus, T. brucei and T. maritima PGK, and may therefore have a role in the independent folding of the two domains or in the "hinge" bending of the molecule during catalysis.	Proline	23-30	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	174-177
10092885-12	1999	It is proposed that the proline residue at 204 in the "hinge" region of PGK plays a role in the stability and catalytic mechanism of the enzyme.	Proline	24-31	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	72-75
10023783-2	1999	Most recently, p53 protein containing an arginine residue in codon 72 was shown to be more effectively degraded by the E6 oncoprotein of human papillomavirus (HPV) than the corresponding proline isoform in cervical carcinoma cells.	Proline	187-194	tumor protein p53	Homo sapiens	15-18
9891067-5	1999	Proto-Lbc transforming activity is much reduced compared to that of onco-Lbc, and a significant increase in transforming activity requires truncation of both the alpha-helical and proline-rich regions in the proto-Lbc C terminus.	Proline	180-187	A-kinase anchoring protein 13	Homo sapiens	208-217
9882751-7	1999	Uptake of proline, glycine and glutamine via system ASC was identified by inhibition with alanine or serine.	Proline	10-17	apoptosis-associated speck-like protein containing a CARD	Bos taurus	52-55
9891044-1	1999	The wild-type p53 protein exhibits a common polymorphism at amino acid 72, resulting in either a proline residue (p53Pro) or an arginine residue (p53Arg) at this position.	Proline	97-104	tumor protein p53	Homo sapiens	14-17
9891069-5	1999	The HPK1 mutant (HPK1-PR), which encodes the proline-rich region alone, blocked JNK activation by Crk and CrkL.	Proline	45-52	CRK proto-oncogene, adaptor protein	Homo sapiens	98-101
9891069-5	1999	The HPK1 mutant (HPK1-PR), which encodes the proline-rich region alone, blocked JNK activation by Crk and CrkL.	Proline	45-52	CRK like proto-oncogene, adaptor protein	Homo sapiens	106-110
9891069-3	1999	We found that HPK1 interacted with Crk and CrkL adaptor proteins in vitro and in vivo and that the proline-rich motifs within HPK1 were involved in the differential interaction of HPK1 with the Crk proteins and Grb2.	Proline	99-106	CRK proto-oncogene, adaptor protein	Homo sapiens	35-38
9891069-3	1999	We found that HPK1 interacted with Crk and CrkL adaptor proteins in vitro and in vivo and that the proline-rich motifs within HPK1 were involved in the differential interaction of HPK1 with the Crk proteins and Grb2.	Proline	99-106	CRK like proto-oncogene, adaptor protein	Homo sapiens	43-47
9891069-3	1999	We found that HPK1 interacted with Crk and CrkL adaptor proteins in vitro and in vivo and that the proline-rich motifs within HPK1 were involved in the differential interaction of HPK1 with the Crk proteins and Grb2.	Proline	99-106	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	126-130
9891069-3	1999	We found that HPK1 interacted with Crk and CrkL adaptor proteins in vitro and in vivo and that the proline-rich motifs within HPK1 were involved in the differential interaction of HPK1 with the Crk proteins and Grb2.	Proline	99-106	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	126-130
9891069-3	1999	We found that HPK1 interacted with Crk and CrkL adaptor proteins in vitro and in vivo and that the proline-rich motifs within HPK1 were involved in the differential interaction of HPK1 with the Crk proteins and Grb2.	Proline	99-106	CRK proto-oncogene, adaptor protein	Homo sapiens	43-46
9891069-3	1999	We found that HPK1 interacted with Crk and CrkL adaptor proteins in vitro and in vivo and that the proline-rich motifs within HPK1 were involved in the differential interaction of HPK1 with the Crk proteins and Grb2.	Proline	99-106	growth factor receptor bound protein 2	Homo sapiens	211-215
9891069-5	1999	The HPK1 mutant (HPK1-PR), which encodes the proline-rich region alone, blocked JNK activation by Crk and CrkL.	Proline	45-52	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	4-8
9891069-5	1999	The HPK1 mutant (HPK1-PR), which encodes the proline-rich region alone, blocked JNK activation by Crk and CrkL.	Proline	45-52	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	17-21
9891069-5	1999	The HPK1 mutant (HPK1-PR), which encodes the proline-rich region alone, blocked JNK activation by Crk and CrkL.	Proline	45-52	mitogen-activated protein kinase 8	Homo sapiens	80-83
10208650-2	1999	The polymorphism comprises a C to T base change at position 609 of the human NQO1 cDNA (C609T) and codes for a proline to serine substitution in the amino acid structure of the NQO1 protein.	Proline	111-118	NAD(P)H quinone dehydrogenase 1	Homo sapiens	77-81
10025789-12	1999	The serine to proline change predicts a kink in the alpha-helix of the transmembrane domain of the PS1 protein that could radically disrupt its normal structure.	Proline	14-21	presenilin 1	Homo sapiens	99-102
9889267-8	1999	Expression of hMSH6 with hMSH2 containing a proline substituted for a conserved Arg524 eliminates the mutator effect and reduces mismatch binding.	Proline	44-51	mutS homolog 6	Homo sapiens	14-19
9889267-8	1999	Expression of hMSH6 with hMSH2 containing a proline substituted for a conserved Arg524 eliminates the mutator effect and reduces mismatch binding.	Proline	44-51	mutS homolog 2	Homo sapiens	25-30
9973406-6	1999	The P--&gt;A mutation in this region abrogated the binding to Lyn, indicating a critical role of proline residues.	Proline	97-104	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	62-65
10208650-2	1999	The polymorphism comprises a C to T base change at position 609 of the human NQO1 cDNA (C609T) and codes for a proline to serine substitution in the amino acid structure of the NQO1 protein.	Proline	111-118	NAD(P)H quinone dehydrogenase 1	Homo sapiens	177-181
10025965-1	1999	Previously we reported that the R73A and H144Q variants of the yeast cyclophilin Cpr3 were virtually inactive in a protease-coupled peptide assay, but retained activity as catalysts of a proline-limited protein folding reaction [Scholz, C. et al.	Proline	187-194	peptidylprolyl isomerase CPR3	Saccharomyces cerevisiae S288C	81-85
10216914-6	1999	Key features of mouse ZP3, including the number and location of cysteine and proline residues and N-linked glycosylation sites, were also conserved in the rat homologue.	Proline	77-84	zona pellucida glycoprotein 3	Mus musculus	22-25
9920772-3	1999	Sequence analyses of these two variants and an isolated MFG-E8 gene segment indicated that the long and short mRNA variants resulted from an alternative splicing of a single pre-mRNA through in-flame inclusion and skipping of one exon, which encodes a proline/threonine (Pro/Thr)-rich domain.	Proline	252-259	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	56-62
10021361-7	1999	The constitutive interaction between Gads and SLP-76 was mediated by the carboxy-terminal SH3 domain of Gads and a 20 amino-acid proline-rich region in SLP-76.	Proline	129-136	GRB2 related adaptor protein 2	Homo sapiens	37-41
10021361-7	1999	The constitutive interaction between Gads and SLP-76 was mediated by the carboxy-terminal SH3 domain of Gads and a 20 amino-acid proline-rich region in SLP-76.	Proline	129-136	lymphocyte cytosolic protein 2	Homo sapiens	46-52
10021361-7	1999	The constitutive interaction between Gads and SLP-76 was mediated by the carboxy-terminal SH3 domain of Gads and a 20 amino-acid proline-rich region in SLP-76.	Proline	129-136	lymphocyte cytosolic protein 2	Homo sapiens	152-158
9915832-10	1999	Exhibiting several domains involved in protein-protein interaction (three proline-rich domains, three leucine-zipper motifs, and an Src homology region 3-like domain), the PRAX-1 may be looked upon as a new adaptator protein.	Proline	74-81	TSPO associated protein 1	Homo sapiens	172-178
9915832-11	1999	We show that both the Src homology region 3-like domain and a proline-rich domain in PRAX-1 are required for the interaction with PBR.	Proline	62-69	TSPO associated protein 1	Homo sapiens	85-91
9915832-11	1999	We show that both the Src homology region 3-like domain and a proline-rich domain in PRAX-1 are required for the interaction with PBR.	Proline	62-69	translocator protein	Homo sapiens	130-133
9890970-7	1999	A GST fusion protein encoding the proline-rich region of Cbl bound to Fyn present in a total cell lysate.	Proline	34-41	hematopoietic prostaglandin D synthase	Rattus norvegicus	2-5
9890943-5	1999	We showed by in vitro experiments that Cbl/p85 association was mediated by the Src homology 3 domain of p85/PI 3-K and the proline-rich region of Cbl.	Proline	123-130	Cbl proto-oncogene	Homo sapiens	39-42
9890943-5	1999	We showed by in vitro experiments that Cbl/p85 association was mediated by the Src homology 3 domain of p85/PI 3-K and the proline-rich region of Cbl.	Proline	123-130	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	43-46
9890943-5	1999	We showed by in vitro experiments that Cbl/p85 association was mediated by the Src homology 3 domain of p85/PI 3-K and the proline-rich region of Cbl.	Proline	123-130	Cbl proto-oncogene	Homo sapiens	146-149
9890970-7	1999	A GST fusion protein encoding the proline-rich region of Cbl bound to Fyn present in a total cell lysate.	Proline	34-41	Cbl proto-oncogene	Rattus norvegicus	57-60
9890970-7	1999	A GST fusion protein encoding the proline-rich region of Cbl bound to Fyn present in a total cell lysate.	Proline	34-41	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	70-73
9890970-8	1999	Far Western blot analysis also indicated that the SH3 domain of Fyn bound preferentially to the proline-rich region of Cbl.	Proline	96-103	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	64-67
9890970-8	1999	Far Western blot analysis also indicated that the SH3 domain of Fyn bound preferentially to the proline-rich region of Cbl.	Proline	96-103	Cbl proto-oncogene	Rattus norvegicus	119-122
9918859-3	1999	Screening for mutations in the entire coding region of the PPARgamma gene yielded a missense C --&gt; G mutation at codon 12, resulting in the substitution of proline with alanine (Pro12Ala).	Proline	159-166	peroxisome proliferator activated receptor gamma	Homo sapiens	59-68
9931508-8	1999	These Drosophila ribosomal protein L22 and L23a have additional Ala-, Lys- and Pro-rich sequences at the amino terminus, which have a resemblance to the carboxy-terminal portion of histone H1.	Proline	79-82	Ribosomal protein L22	Drosophila melanogaster	17-38
9931508-8	1999	These Drosophila ribosomal protein L22 and L23a have additional Ala-, Lys- and Pro-rich sequences at the amino terminus, which have a resemblance to the carboxy-terminal portion of histone H1.	Proline	79-82	Ribosomal protein L23A	Drosophila melanogaster	43-47
9878785-2	1999	Its structure appears to satisfy the substrate requirements of the proteinase, dipeptidyl peptidase IV which removes dipeptides from the amino terminus of peptides containing proline as the penultimate amino acid.	Proline	175-182	dipeptidylpeptidase 4	Rattus norvegicus	79-102
10189832-20	1999	The hinge region of IgA1 is relatively resistant to proteolysis because of a high proline content and presence of several oligosaccharide side chains.	Proline	82-89	immunoglobulin heavy constant alpha 1	Homo sapiens	20-24
9885244-6	1999	The interaction between vinexin and vinculin was mediated by two SH3 domains of vinexin and the proline-rich region of vinculin.	Proline	96-103	sorbin and SH3 domain containing 3	Mus musculus	24-31
9885244-6	1999	The interaction between vinexin and vinculin was mediated by two SH3 domains of vinexin and the proline-rich region of vinculin.	Proline	96-103	vinculin	Mus musculus	36-44
9885244-6	1999	The interaction between vinexin and vinculin was mediated by two SH3 domains of vinexin and the proline-rich region of vinculin.	Proline	96-103	vinculin	Mus musculus	119-127
9920725-2	1999	Specific changes by mutagenesis of a strictly conserved threonine (H) into lysine (K), proline (P) or alanine (A) at position 343 of the human VPAC1 receptor resulted in its constitutive activation with respect to cAMP production.	Proline	87-94	vasoactive intestinal peptide receptor 1	Homo sapiens	143-157
9872994-6	1999	This interaction involves the Tec SH3 domain and the proline-rich motifs in CD28.	Proline	53-60	tec protein tyrosine kinase	Mus musculus	30-33
9872994-6	1999	This interaction involves the Tec SH3 domain and the proline-rich motifs in CD28.	Proline	53-60	CD28 antigen	Mus musculus	76-80
9923599-6	1999	Escherichia coli, transformed with a mutant ble having leucine instead of proline at N-terminal amino acid position 7, lost resistance to Bm, although the cell maintained the survival benefit.	Proline	74-81	bleomycin resistance protein	Escherichia coli	44-47
10582130-1	1999	Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins.	Proline	9-16	peptidase D	Homo sapiens	95-104
9854021-7	1999	The crucial role of Cys424 in Nop2p is intriguing, due to the critical roles that cysteine residues adjacent to a proline have in a number of nucleotide-modifying enzymes.	Proline	114-121	rRNA (cytosine-C5-)-methyltransferase NOP2	Saccharomyces cerevisiae S288C	30-35
10071197-1	1999	A previous report in this journal has suggested that germline deletions in the proline-alanine-rich (PAPA-repeat) region of P57 (KIP2) are associated with increased risk of a variety of cancers, including breast cancer.	Proline	79-86	cyclin dependent kinase inhibitor 1C	Homo sapiens	124-127
10343108-5	1999	In vitro binding assays confirmed that a proline-rich cytoplasmic fragment of BAI1 interacted with the Src homology 3 (SH3) domain of BAIAP2.	Proline	41-48	BAR/IMD domain containing adaptor protein 2	Homo sapiens	134-140
10393434-3	1999	The predicted TUTR1 protein is extremely hydrophilic and contains two proline-rich motifs at its C-terminus.	Proline	70-77	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	14-19
9914503-4	1999	The combination of a Pro at P2 and His at P3 abolished cleavage by cathepsin L, so that only cruzipain was able to cleave the HPGGP peptide at the GG bond.	Proline	21-24	cathepsin L	Homo sapiens	67-78
10071197-1	1999	A previous report in this journal has suggested that germline deletions in the proline-alanine-rich (PAPA-repeat) region of P57 (KIP2) are associated with increased risk of a variety of cancers, including breast cancer.	Proline	79-86	cyclin dependent kinase inhibitor 1C	Homo sapiens	129-133
9867803-3	1999	The carboxyl terminus of Nix, including a transmembrane domain, is highly homologous to Nip3 but it bears a longer and distinct asparagine/proline-rich N terminus.	Proline	139-146	BCL2 interacting protein 3 like	Homo sapiens	25-28
10100484-5	1999	Contrin is highly basic and is rich in the amino acids arginine and proline.	Proline	68-75	Y-box binding protein 2	Homo sapiens	0-7
10051177-9	1999	Insulin lispro, a recombinant insulin analogue, is identical to human insulin except for the transposition of proline and lysine at positions 28 and 29 in the C-terminus of the B chain.	Proline	110-117	insulin	Homo sapiens	0-7
10570909-0	1999	C16orf5, a novel proline-rich gene at 16p13.3, is highly expressed in the brain.	Proline	17-24	cell death inducing p53 target 1	Homo sapiens	0-7
10570909-1	1999	A novel gene has been characterized, designated C16orf5, with an unusually high content of proline residues (40% over 104 residues) at the N-terminus of the protein.	Proline	91-98	cell death inducing p53 target 1	Homo sapiens	48-55
10195445-5	1999	The insertion of Pro, Gly-Ile or Gly-Pro in this hinge region of L-CA-MA caused retention of both antibacterial and antitumor activity while causing a significant decrease in hemolytic activity.	Proline	17-20	protein tyrosine phosphatase receptor type C	Homo sapiens	65-69
9892021-7	1999	A proline-rich region, which contains two PXXP motifs for the SH3 domain-binding site, was detected in the PTTG protein sequence.	Proline	2-9	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	107-111
9892021-8	1999	When these proline residues were changed by site-directed mutagenesis, PTTG in vitro transforming and in vivo tumor-inducing activity, as well as stimulation of basic fibroblast growth factor, was abrogated.	Proline	11-18	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	71-75
10195445-5	1999	The insertion of Pro, Gly-Ile or Gly-Pro in this hinge region of L-CA-MA caused retention of both antibacterial and antitumor activity while causing a significant decrease in hemolytic activity.	Proline	37-40	protein tyrosine phosphatase receptor type C	Homo sapiens	65-69
10697434-2	1999	Synthesis of proline analogues of melphalan and theirs susceptibility to the action of prolidase.	Proline	13-20	peptidase D	Homo sapiens	87-96
10080694-5	1999	Sequence analysis revealed that AIR1 encodes a protein that is related to a large family of proteins that consist of a proline-rich or glycine-rich N-terminus and a hydrophobic, possibly membrane spanning C-terminus.	Proline	119-126	Auxin-Induced in Root cultures 1	Arabidopsis thaliana	32-36
10080694-7	1999	Surprisingly, AIR1 lacks the proline-rich or glycine-rich N-terminus which is thought to be important for interaction with the cell wall.	Proline	29-36	Auxin-Induced in Root cultures 1	Arabidopsis thaliana	14-18
10697434-4	1999	The synthesis of proline analogues of melphalan (well known antineoplastic agent) conjugated through imido-bond (potential target for prolidase action) has been performed.	Proline	17-24	peptidase D	Homo sapiens	134-143
10697434-6	1999	It suggests that targeting of prolidase as a proline analogue of melphalan-converting enzyme may serve as a novel strategy in therapy of neoplastic diseases.	Proline	45-52	peptidase D	Homo sapiens	30-39
9860983-7	1998	The interaction between LMO-4 and mouse DEAF-1 maps to a proline-rich C-terminal domain of mouse DEAF-1, distinct from the helix-loop-helix and GATA domains previously shown to interact with LMOs, thus defining an additional LIM-interacting domain.	Proline	57-64	LIM domain only 4	Mus musculus	24-29
9860983-7	1998	The interaction between LMO-4 and mouse DEAF-1 maps to a proline-rich C-terminal domain of mouse DEAF-1, distinct from the helix-loop-helix and GATA domains previously shown to interact with LMOs, thus defining an additional LIM-interacting domain.	Proline	57-64	DEAF1, transcription factor	Mus musculus	40-46
9860983-7	1998	The interaction between LMO-4 and mouse DEAF-1 maps to a proline-rich C-terminal domain of mouse DEAF-1, distinct from the helix-loop-helix and GATA domains previously shown to interact with LMOs, thus defining an additional LIM-interacting domain.	Proline	57-64	DEAF1, transcription factor	Mus musculus	97-103
9826510-2	1998	SM3 recognises the core repeating motif (Pro-Asp-Thr-Arg-Pro) of aberrantly glycosylated epithelial mucin MUC1, and has potential as a therapeutic and diagnostic tool.	Proline	41-44	mucin 1, cell surface associated	Homo sapiens	106-110
9857184-6	1998	Furthermore, Mona contains a unique proline-rich region located between the SH2 domain and the C-terminal SH3 domain, and is apparently devoid of any catalytic domain.	Proline	36-43	GRB2-related adaptor protein 2	Mus musculus	13-17
9843987-0	1998	Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation.	Proline	20-27	CD2 molecule	Homo sapiens	53-56
9851827-13	1998	In addition, recombinant p67(phox) or a peptide containing proline-rich sequence of p22(phox) (residues 149-162) induces the attenuation of the amphiphile-mediated enhancement of fluorescence from IANBD-labeled p47(phox).	Proline	59-66	CD33 molecule	Homo sapiens	25-28
9851827-13	1998	In addition, recombinant p67(phox) or a peptide containing proline-rich sequence of p22(phox) (residues 149-162) induces the attenuation of the amphiphile-mediated enhancement of fluorescence from IANBD-labeled p47(phox).	Proline	59-66	calcineurin like EF-hand protein 1	Homo sapiens	84-87
9851827-13	1998	In addition, recombinant p67(phox) or a peptide containing proline-rich sequence of p22(phox) (residues 149-162) induces the attenuation of the amphiphile-mediated enhancement of fluorescence from IANBD-labeled p47(phox).	Proline	59-66	pleckstrin	Homo sapiens	88-92
9851827-13	1998	In addition, recombinant p67(phox) or a peptide containing proline-rich sequence of p22(phox) (residues 149-162) induces the attenuation of the amphiphile-mediated enhancement of fluorescence from IANBD-labeled p47(phox).	Proline	59-66	pleckstrin	Homo sapiens	211-214
9851827-13	1998	In addition, recombinant p67(phox) or a peptide containing proline-rich sequence of p22(phox) (residues 149-162) induces the attenuation of the amphiphile-mediated enhancement of fluorescence from IANBD-labeled p47(phox).	Proline	59-66	pleckstrin	Homo sapiens	88-92
9920351-4	1998	A newly discovered association between a leucine(7)-to-proline(7) polymorphism (Pro(7)) in the signal peptide of NPY and a high cholesterol level may provide new ideas for the genetic regulation of cholesterol metabolism.	Proline	55-62	neuropeptide Y	Homo sapiens	113-116
9822744-2	1998	The results obtained indicate that laminin, an extracellular matrix molecule capable of selectively stimulating axonal extension and promoting MAP1B phosphorylation at a proline-directed protein kinase epitope, selectively stimulates p35 expression, increases its association with the subcortical cytoskeleton, and accelerates its redistribution to the axonal growth cones.	Proline	170-177	microtubule associated protein 1B	Homo sapiens	143-148
9820825-7	1998	The Rab4 cleavage sites corresponded to Arg-81 and Pro-87 of Rab5, and taken together with the finding that Rab5 was not cleaved at Arg-91 this analysis defines an eight-residue surface-exposed conformationally variable region lying in the centre of Switch II.	Proline	51-54	RAB4A, member RAS oncogene family	Homo sapiens	4-8
9820825-7	1998	The Rab4 cleavage sites corresponded to Arg-81 and Pro-87 of Rab5, and taken together with the finding that Rab5 was not cleaved at Arg-91 this analysis defines an eight-residue surface-exposed conformationally variable region lying in the centre of Switch II.	Proline	51-54	RAB5A, member RAS oncogene family	Homo sapiens	61-65
9817918-8	1998	Point mutations in XLIS identified the C-terminal serine/proline-rich region as potentially important for protein function.	Proline	57-64	doublecortin	Homo sapiens	19-23
9817931-3	1998	Two alleles of the calcitonin receptor gene ( CTR ) exist: a base mutation T--&gt;C in the third intracellular C-terminal domain changes a proline (CCG) at position 447 to a leucine (CTG).	Proline	139-146	calcitonin receptor	Homo sapiens	19-43
9817931-3	1998	Two alleles of the calcitonin receptor gene ( CTR ) exist: a base mutation T--&gt;C in the third intracellular C-terminal domain changes a proline (CCG) at position 447 to a leucine (CTG).	Proline	139-146	calcitonin receptor	Homo sapiens	46-49
9820821-10	1998	The recombinant DD4 with the His314--&gt;Pro (the corresponding residue of DD1) mutation showed intermediate changes in the properties between those of wild-type DD4 and CDD4-1.	Proline	41-44	aldo-keto reductase family 1 member C4	Homo sapiens	16-19
9820821-10	1998	The recombinant DD4 with the His314--&gt;Pro (the corresponding residue of DD1) mutation showed intermediate changes in the properties between those of wild-type DD4 and CDD4-1.	Proline	41-44	aldo-keto reductase family 1 member C1	Homo sapiens	75-78
9820821-10	1998	The recombinant DD4 with the His314--&gt;Pro (the corresponding residue of DD1) mutation showed intermediate changes in the properties between those of wild-type DD4 and CDD4-1.	Proline	41-44	aldo-keto reductase family 1 member C4	Homo sapiens	162-165
9858249-1	1998	We report the identification in five patients (three families) affected with type 2B von Willebrand disease (VWD) of three heterozygous nucleotide substitutions at the codon for arginine 543, 545 and 578 of the mature von Willebrand factor (VWF) subunit resulting in a glutamine, proline and leucine substitution, respectively.	Proline	280-287	von Willebrand factor	Homo sapiens	218-239
9831690-7	1998	Five polymorphisms have been identified in the transforming growth factor-beta1 gene at positions G-800A, C-509T in the promoter region, Leu10--&gt;Pro, Arg25--&gt;Pro in exon 1 and Thr263--&gt;Ile in exon 5.	Proline	148-151	transforming growth factor beta 1	Homo sapiens	47-79
9831690-7	1998	Five polymorphisms have been identified in the transforming growth factor-beta1 gene at positions G-800A, C-509T in the promoter region, Leu10--&gt;Pro, Arg25--&gt;Pro in exon 1 and Thr263--&gt;Ile in exon 5.	Proline	164-167	transforming growth factor beta 1	Homo sapiens	47-79
9874198-4	1998	It is shown here that TLE2 and TLE1 are transcriptional repressors that contain two separate repression domains, located either within a Gln-rich amino terminal region or within an internal domain characterized by an abundance of Ser, Thr, and Pro residues.	Proline	244-247	TLE family member 2, transcriptional corepressor	Homo sapiens	22-26
9832628-0	1998	Zep: A novel zinc finger protein containing a large proline-rich domain.	Proline	52-59	zinc finger protein 207	Mus musculus	0-3
9832628-4	1998	In addition to the proline-rich domain, Zep has an acidic domain and a serine/threonine-rich domain, all of which are frequently found in many transcription factors.	Proline	19-26	zinc finger protein 207	Mus musculus	40-43
9880037-3	1998	This variant contains only three instead of the usual five copies of a short peptide repeat [Pro-Gln/His-Gly-Gly-Gly-(Gly)-TrpGly-Gln] characteristic of PrP, with an additional Trp to Gly substitution in codon 102.	Proline	93-96	major prion protein	Capra hircus	153-156
9822744-2	1998	The results obtained indicate that laminin, an extracellular matrix molecule capable of selectively stimulating axonal extension and promoting MAP1B phosphorylation at a proline-directed protein kinase epitope, selectively stimulates p35 expression, increases its association with the subcortical cytoskeleton, and accelerates its redistribution to the axonal growth cones.	Proline	170-177	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	234-237
9819391-9	1998	Both coimmunoprecipitation and tyrosine phosphorylation depend on the same proline-rich class II Src SH3 binding site required for in vitro association.	Proline	75-82	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	97-100
9819408-4	1998	GSK3beta binds directly to an STDRSPYE site in MUC1 and phosphorylates the serine adjacent to proline.	Proline	94-101	glycogen synthase kinase 3 beta	Homo sapiens	0-8
9843217-3	1998	ATM also contains a proline-rich region and a leucine zipper, both of which implicate this protein in signal transduction.	Proline	20-27	ATM serine/threonine kinase	Homo sapiens	0-3
9846584-0	1998	Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels.	Proline	31-38	neuropeptide Y	Homo sapiens	80-94
9843217-4	1998	The proline-rich region has been shown to bind to the SH3 domain of c-Abl, which facilitates its phosphorylation and activation by ATM.	Proline	4-11	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	68-73
9843217-4	1998	The proline-rich region has been shown to bind to the SH3 domain of c-Abl, which facilitates its phosphorylation and activation by ATM.	Proline	4-11	ATM serine/threonine kinase	Homo sapiens	131-134
9819408-4	1998	GSK3beta binds directly to an STDRSPYE site in MUC1 and phosphorylates the serine adjacent to proline.	Proline	94-101	mucin 1, cell surface associated	Homo sapiens	47-51
9846584-5	1998	We report here the identification of a common Leu(7)-to-Pro(7) polymorphism in the signal peptide of NPY.	Proline	56-59	beta-1,3-glucuronyltransferase 1	Homo sapiens	46-52
9846584-5	1998	We report here the identification of a common Leu(7)-to-Pro(7) polymorphism in the signal peptide of NPY.	Proline	56-59	neuropeptide Y	Homo sapiens	101-104
9826645-1	1998	Dipeptidyl peptidase IV (EC 3.4.14.5; DPP IV), also known as the leukocyte differentiation antigen CD26 when found as an extracellular membrane-bound proline specific serine protease, cleaves a dipeptide from the N terminus of a polypeptide chain containing a proline residue in the penultimate position.	Proline	150-157	dipeptidyl peptidase 4	Homo sapiens	0-23
9879888-5	1998	pDiCal possesses three consensus sequences of the calreticulin family of proteins: a neutral N-terminal region with a putative signal sequence; a proline- and tryptophan-rich P region; and a highly acidic C-terminal region.	Proline	146-153	calreticulin	Oryctolagus cuniculus	50-62
9879669-1	1998	Prolidase [E.C.3.4.13.9] is a cytosolic exopeptidase that catalyses the hydrolysis of C-terminal proline containing dipeptides or tripeptides.	Proline	97-104	peptidase D	Homo sapiens	0-9
9847097-1	1998	The cDNA clone ERD5 (early responsive to dehydration), isolated from 1-h-dehydrated Arabidopsis, encodes a precursor of proline (Pro) dehydrogenase (ProDH), which is a mitochondrial enzyme involved in the first step of the conversion of Pro to glutamic acid.	Proline	129-132	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	15-19
9847097-1	1998	The cDNA clone ERD5 (early responsive to dehydration), isolated from 1-h-dehydrated Arabidopsis, encodes a precursor of proline (Pro) dehydrogenase (ProDH), which is a mitochondrial enzyme involved in the first step of the conversion of Pro to glutamic acid.	Proline	129-132	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	149-154
9822705-9	1998	Also, in contrast to previous observations, transfection studies of PtK2 cells showed that mouse K16 (without the proline) and also human K16 (with the proline) can incorporate into the endogenous K8/K18 network without detrimental effect.	Proline	152-159	keratin 16	Homo sapiens	138-141
9822705-9	1998	Also, in contrast to previous observations, transfection studies of PtK2 cells showed that mouse K16 (without the proline) and also human K16 (with the proline) can incorporate into the endogenous K8/K18 network without detrimental effect.	Proline	152-159	keratin 18	Homo sapiens	200-203
9826645-1	1998	Dipeptidyl peptidase IV (EC 3.4.14.5; DPP IV), also known as the leukocyte differentiation antigen CD26 when found as an extracellular membrane-bound proline specific serine protease, cleaves a dipeptide from the N terminus of a polypeptide chain containing a proline residue in the penultimate position.	Proline	150-157	dipeptidyl peptidase 4	Homo sapiens	38-44
9826645-1	1998	Dipeptidyl peptidase IV (EC 3.4.14.5; DPP IV), also known as the leukocyte differentiation antigen CD26 when found as an extracellular membrane-bound proline specific serine protease, cleaves a dipeptide from the N terminus of a polypeptide chain containing a proline residue in the penultimate position.	Proline	150-157	dipeptidyl peptidase 4	Homo sapiens	99-103
9826645-1	1998	Dipeptidyl peptidase IV (EC 3.4.14.5; DPP IV), also known as the leukocyte differentiation antigen CD26 when found as an extracellular membrane-bound proline specific serine protease, cleaves a dipeptide from the N terminus of a polypeptide chain containing a proline residue in the penultimate position.	Proline	260-267	dipeptidyl peptidase 4	Homo sapiens	0-23
9826645-1	1998	Dipeptidyl peptidase IV (EC 3.4.14.5; DPP IV), also known as the leukocyte differentiation antigen CD26 when found as an extracellular membrane-bound proline specific serine protease, cleaves a dipeptide from the N terminus of a polypeptide chain containing a proline residue in the penultimate position.	Proline	260-267	dipeptidyl peptidase 4	Homo sapiens	38-44
9826645-1	1998	Dipeptidyl peptidase IV (EC 3.4.14.5; DPP IV), also known as the leukocyte differentiation antigen CD26 when found as an extracellular membrane-bound proline specific serine protease, cleaves a dipeptide from the N terminus of a polypeptide chain containing a proline residue in the penultimate position.	Proline	260-267	dipeptidyl peptidase 4	Homo sapiens	99-103
9845338-4	1998	Three-dimensional modelling of the new EF-2 sequences enabled the identification of amino acid residues that may be important for conferring low temperature activity and included greater structural flexibility produced by fewer salt bridges, less packed hydrophobic cores and the reduction of proline residues in loop structures.	Proline	293-300	eukaryotic translation elongation factor 2	Homo sapiens	39-43
9819200-9	1998	Replacement of the arginine-9 position with a proline decreases binding affinity to ACA 10-fold.	Proline	46-53	small nucleolar RNA, H/ACA box 10	Homo sapiens	84-90
9804776-11	1998	Phosphopeptide binding to the cSH2 domain increased p110alpha activity only in the context of an intact p85 containing both the nSH2 domain and residues 1-322 (the SH3, proline-rich and breakpoint cluster region-homolgy domains).	Proline	169-176	chorionic somatomammotropin hormone 2	Homo sapiens	30-34
9822597-5	1998	Profilin associates both in vivo and in vitro with N-WASP at proline-rich sites different from those to which Ash/Grb2 binds.	Proline	61-68	WASP like actin nucleation promoting factor	Homo sapiens	51-57
11711061-2	1998	To elucidate the role for proline in plant responses to heavy metal stress, we studied the effect of proline on Cd-induced and Zn-induced inhibition of glucose-6-phosphate dehydrogenase (G-6-PDH; EC 1.1.1.49) and nitrate reductase (NR; EC 1.6.6.2) in vitro.	Proline	101-108	glucose-6-phosphate dehydrogenase	Homo sapiens	152-185
9804755-0	1998	Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.	Proline	97-104	annexin A6	Homo sapiens	50-53
9804776-11	1998	Phosphopeptide binding to the cSH2 domain increased p110alpha activity only in the context of an intact p85 containing both the nSH2 domain and residues 1-322 (the SH3, proline-rich and breakpoint cluster region-homolgy domains).	Proline	169-176	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	52-61
9804755-0	1998	Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.	Proline	97-104	ribosomal protein S6 kinase B2	Homo sapiens	65-83
9804817-5	1998	PSTPIP 2 lacks an SH3 domain but contains a region predicted to bind to PEST-type PTPs, and structure-function analyses demonstrate that PSTPIP 2 interacts with the proline-rich C terminus of the PEST-type PTP hematopoietic stem cell factor in a manner similar to that previously demonstrated for PSTPIP.	Proline	165-172	proline-serine-threonine phosphatase interacting protein 2	Homo sapiens	0-8
9804817-5	1998	PSTPIP 2 lacks an SH3 domain but contains a region predicted to bind to PEST-type PTPs, and structure-function analyses demonstrate that PSTPIP 2 interacts with the proline-rich C terminus of the PEST-type PTP hematopoietic stem cell factor in a manner similar to that previously demonstrated for PSTPIP.	Proline	165-172	proline-serine-threonine phosphatase interacting protein 2	Homo sapiens	137-145
9792678-5	1998	Deletion and substitution mutant analyses revealed that the SH3 domain of Drosophila cortactin binds to a PXXP motif in the proline-rich domain of Drosophila ZO-1.	Proline	124-131	cortactin	Drosophila melanogaster	85-94
9804817-5	1998	PSTPIP 2 lacks an SH3 domain but contains a region predicted to bind to PEST-type PTPs, and structure-function analyses demonstrate that PSTPIP 2 interacts with the proline-rich C terminus of the PEST-type PTP hematopoietic stem cell factor in a manner similar to that previously demonstrated for PSTPIP.	Proline	165-172	protein tyrosine phosphatase receptor type U	Homo sapiens	82-85
9804817-5	1998	PSTPIP 2 lacks an SH3 domain but contains a region predicted to bind to PEST-type PTPs, and structure-function analyses demonstrate that PSTPIP 2 interacts with the proline-rich C terminus of the PEST-type PTP hematopoietic stem cell factor in a manner similar to that previously demonstrated for PSTPIP.	Proline	165-172	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	0-6
9804755-2	1998	However, the amino acid sequence of p70beta differs from that of p70alpha in the noncatalytic amino-terminal region and in the carboxyl-terminal tail, which contains a proline-rich region.	Proline	168-175	ribosomal protein S6 kinase B2	Homo sapiens	36-43
9804836-3	1998	The sequences of four peptides derived from the purified protein matched portions of an expressed sequence tag (EST) sequence, and the EST clone was used to obtain cDNA clones encoding the pp37 protein, which shares sequence similarity with the PST PIP (proline, serine, threonine phosphatase interacting protein)/CDC15 family of protein-tyrosine phosphatase substrates.	Proline	254-261	proline-serine-threonine phosphatase-interacting protein 2	Mus musculus	189-193
9811850-3	1998	p28 also shares features with linker histone H1, and like H1, p28 is multiply phosphorylated, at least in part, by a proline-directed, Cdc2-type kinase.	Proline	117-124	golgi SNAP receptor complex member 1	Homo sapiens	0-3
9811850-3	1998	p28 also shares features with linker histone H1, and like H1, p28 is multiply phosphorylated, at least in part, by a proline-directed, Cdc2-type kinase.	Proline	117-124	golgi SNAP receptor complex member 1	Homo sapiens	62-65
9792678-5	1998	Deletion and substitution mutant analyses revealed that the SH3 domain of Drosophila cortactin binds to a PXXP motif in the proline-rich domain of Drosophila ZO-1.	Proline	124-131	polychaetoid	Drosophila melanogaster	158-162
9792688-4	1998	A combination of in vitro and in vivo binding assays indicate that both ZO-2 and occludin interact with specific domains within the N-terminal (MAGUK-like) half of ZO-1, whereas the unique proline-rich C-terminal half of ZO-1 cosediments with F-actin.	Proline	189-196	tight junction protein 2	Canis lupus familiaris	72-76
9792688-4	1998	A combination of in vitro and in vivo binding assays indicate that both ZO-2 and occludin interact with specific domains within the N-terminal (MAGUK-like) half of ZO-1, whereas the unique proline-rich C-terminal half of ZO-1 cosediments with F-actin.	Proline	189-196	occludin	Canis lupus familiaris	81-89
9799487-6	1998	The primary difference in the two groups is the loop conformation of residue Pro 402, which is serine in muscle PK.	Proline	77-80	pyruvate kinase PKLR	Oryctolagus cuniculus	112-114
9804946-8	1998	Another polymorphism encodes for a leucine to proline substitution in the intracellular cytoplasmic tail of CCR-3.	Proline	46-53	C-C motif chemokine receptor 3	Homo sapiens	108-113
9799227-0	1998	A four-to-one association between peptide motifs: four C-terminal domains from cholinesterase assemble with one proline-rich attachment domain (PRAD) in the secretory pathway.	Proline	112-119	butyrylcholinesterase	Homo sapiens	79-93
9814502-1	1998	A missense and loss of function mutation of the Na+/I- symporter (NIS) gene, T354P [Thr354--&gt;Pro (ACA--&gt;CCA)], was found in the homozygous state in two unrelated Japanese patients with iodide transport defect.	Proline	96-99	solute carrier family 5 member 5	Homo sapiens	48-64
9799598-9	1998	The predicted mouse GPR37 protein contains seven putative hydrophobic transmembrane domains, as well as a long (249 amino acid residues), arginine- and proline-rich amino-terminal extracellular domain, which is also a distinctive feature of the human GPR37 receptor.	Proline	152-159	G protein-coupled receptor 37	Mus musculus	20-25
9763511-5	1998	Here we report that a proline rich sequence in the amino terminus of tau interacts with the SH3 domains of fyn and src non-receptor tyrosine kinases.	Proline	22-29	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	107-110
9763511-5	1998	Here we report that a proline rich sequence in the amino terminus of tau interacts with the SH3 domains of fyn and src non-receptor tyrosine kinases.	Proline	22-29	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	115-118
9846828-8	1998	In comparison to this latter sequence, there was a C--&gt;T change at amino acid position 87 (CCT--&gt;CTT) which may result in a Pro to Leu change.	Proline	130-133	CCT	Homo sapiens	94-97
9799332-5	1998	The most prevalent isoform corresponded to the Ser/Thr/Pro-rich C type of human MCP.	Proline	55-58	CD46 molecule	Homo sapiens	80-83
9814502-1	1998	A missense and loss of function mutation of the Na+/I- symporter (NIS) gene, T354P [Thr354--&gt;Pro (ACA--&gt;CCA)], was found in the homozygous state in two unrelated Japanese patients with iodide transport defect.	Proline	96-99	solute carrier family 5 member 5	Homo sapiens	66-69
10068039-8	1998	The two cross-reactive antibodies (K 11 and K 15) recognize the proline-rich region of the U1C protein (amino acids 98 126) and cross-react with proline-rich regions in Sm-B/B" (amino acids 163-184) and U1A (amino acids 187-204).	Proline	64-71	small nuclear ribonucleoprotein polypeptide C	Homo sapiens	91-94
9822825-3	1998	Unexpectedly, most other naturally occurring L-amino acids found in proteins (with the exception of proline, lysine, arginine and histidine) have the same effect on the expression of BAP3.	Proline	100-107	amino acid transporter BAP3	Saccharomyces cerevisiae S288C	183-187
10068039-8	1998	The two cross-reactive antibodies (K 11 and K 15) recognize the proline-rich region of the U1C protein (amino acids 98 126) and cross-react with proline-rich regions in Sm-B/B" (amino acids 163-184) and U1A (amino acids 187-204).	Proline	145-152	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	169-175
9786927-5	1998	We report here the identification of a novel serine- and proline-rich GTPase-activating protein, CdGAP, which is active in vitro on both Cdc42 and Rac.	Proline	57-64	Rho GTPase activating protein 31	Homo sapiens	97-102
9790984-2	1998	Polymerase chain reaction and subsequent direct sequencing of platelet RNA and genomic DNA revealed three single nucleotide substitutions of the integrin beta3 subunit gene (His (CAT)-280 to Pro (CCT), Cys (TGT)-560 to Phe (TTT), and Gly(GGC)-579 to Ser(AGC)).	Proline	191-194	CCT	Homo sapiens	196-199
9786927-5	1998	We report here the identification of a novel serine- and proline-rich GTPase-activating protein, CdGAP, which is active in vitro on both Cdc42 and Rac.	Proline	57-64	cell division cycle 42	Homo sapiens	137-142
9786927-0	1998	CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac.	Proline	15-22	Rho GTPase activating protein 31	Homo sapiens	0-5
9786927-0	1998	CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac.	Proline	15-22	cell division cycle 42	Homo sapiens	58-63
9786927-5	1998	We report here the identification of a novel serine- and proline-rich GTPase-activating protein, CdGAP, which is active in vitro on both Cdc42 and Rac.	Proline	57-64	AKT serine/threonine kinase 1	Homo sapiens	147-150
9786927-0	1998	CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac.	Proline	15-22	AKT serine/threonine kinase 1	Homo sapiens	68-71
9856337-5	1998	In addition, the proline-rich domain of Sos also bound to the SH3 domains of other src-type tyrosine kinases, src and fyn, but not to that of PLC-gamma.	Proline	17-24	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	83-86
9856337-5	1998	In addition, the proline-rich domain of Sos also bound to the SH3 domains of other src-type tyrosine kinases, src and fyn, but not to that of PLC-gamma.	Proline	17-24	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	110-113
9856337-5	1998	In addition, the proline-rich domain of Sos also bound to the SH3 domains of other src-type tyrosine kinases, src and fyn, but not to that of PLC-gamma.	Proline	17-24	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	118-121
9790668-6	1998	The IgG affects the rate at which thrombin cleaves various peptide p-nitroanilide substrates with arginine in the P1 position, increasing the kcat for substrates with a P2 glycine residue but generally decreasing the kcat for substrates with a P2 proline.	Proline	247-254	coagulation factor II, thrombin	Homo sapiens	34-42
9774458-3	1998	We have shown that the FH proteins Bni1p and Bnr1p are potential targets of the Rho family small GTP-binding proteins and bind to an actin-binding protein, profilin, at their proline-rich FH1 domains to regulate reorganization of the actin cytoskeleton in the yeast Saccharomyces cerevisiae.	Proline	175-182	formin BNI1	Saccharomyces cerevisiae S288C	35-40
9774458-3	1998	We have shown that the FH proteins Bni1p and Bnr1p are potential targets of the Rho family small GTP-binding proteins and bind to an actin-binding protein, profilin, at their proline-rich FH1 domains to regulate reorganization of the actin cytoskeleton in the yeast Saccharomyces cerevisiae.	Proline	175-182	formin BNR1	Saccharomyces cerevisiae S288C	45-50
9774458-3	1998	We have shown that the FH proteins Bni1p and Bnr1p are potential targets of the Rho family small GTP-binding proteins and bind to an actin-binding protein, profilin, at their proline-rich FH1 domains to regulate reorganization of the actin cytoskeleton in the yeast Saccharomyces cerevisiae.	Proline	175-182	profilin	Saccharomyces cerevisiae S288C	156-164
9790668-7	1998	The allosteric effect of the IgG is altered by deletion of Pro-60b, Pro-60c, and Trp-60d from the 60-loop of thrombin, which lies between exosite II and the catalytic triad.	Proline	59-62	coagulation factor II, thrombin	Homo sapiens	109-117
9790668-7	1998	The allosteric effect of the IgG is altered by deletion of Pro-60b, Pro-60c, and Trp-60d from the 60-loop of thrombin, which lies between exosite II and the catalytic triad.	Proline	68-71	coagulation factor II, thrombin	Homo sapiens	109-117
9788432-6	1998	HPK1-binding to the first SH3 domain of CRKL is direct and occurs via proline-rich motifs in the C-terminal, non-catalytic portion of HPK1.	Proline	70-77	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	0-4
9811447-1	1998	The SH2/SH3 adapters Nck, Grb2 and Crk promote the assembly of signaling complexes by binding to tyrosine phosphorylated proteins using their SH2 domains and to proline-rich sequences on effector molecules using their SH3 domains.	Proline	161-168	NCK adaptor protein 1 L homeolog	Xenopus laevis	21-24
9811447-1	1998	The SH2/SH3 adapters Nck, Grb2 and Crk promote the assembly of signaling complexes by binding to tyrosine phosphorylated proteins using their SH2 domains and to proline-rich sequences on effector molecules using their SH3 domains.	Proline	161-168	growth factor receptor bound protein 2 L homeolog	Xenopus laevis	26-30
9811447-1	1998	The SH2/SH3 adapters Nck, Grb2 and Crk promote the assembly of signaling complexes by binding to tyrosine phosphorylated proteins using their SH2 domains and to proline-rich sequences on effector molecules using their SH3 domains.	Proline	161-168	v-crk avian sarcoma virus CT10 oncogene homolog L homeolog	Xenopus laevis	35-38
9811450-4	1998	Analysis of the sequence showed that hPTTG has an amino-terminal basic domain and a carboxyl-terminal acidic domain, and that it is a proline-rich protein with several putative SH3-binding sites.	Proline	134-141	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	37-42
9788606-2	1998	A common polymorphism of p53, encoding either proline or arginine at position 72, affects the susceptibility of p53 to E6-mediated degradation in vivo; Caucasian women homozygous for arginine 72 reportedly are about seven times more susceptible to HPV-associated carcinoma of the cervix than heterozygotes.	Proline	46-53	tumor protein p53	Homo sapiens	25-28
9788606-2	1998	A common polymorphism of p53, encoding either proline or arginine at position 72, affects the susceptibility of p53 to E6-mediated degradation in vivo; Caucasian women homozygous for arginine 72 reportedly are about seven times more susceptible to HPV-associated carcinoma of the cervix than heterozygotes.	Proline	46-53	tumor protein p53	Homo sapiens	112-115
9788432-6	1998	HPK1-binding to the first SH3 domain of CRKL is direct and occurs via proline-rich motifs in the C-terminal, non-catalytic portion of HPK1.	Proline	70-77	CRK like proto-oncogene, adaptor protein	Homo sapiens	40-44
9742220-2	1998	The MLK2 structure is composed of a Src homology 3 (SH3) domain, two leucine zippers, a basic motif, a Cdc42/Rac interactive binding motif and a large C-terminal domain rich in proline, serine and threonine residues.	Proline	177-184	mitogen-activated protein kinase kinase kinase 10	Homo sapiens	4-8
9748234-6	1998	A series of analysis with C3G deletion mutants revealed a proline-rich Cas-binding site (Ala0-Pro1-Pro2-Lys3-Pro4-Pro5-Leu6-Pro7) located NH2-terminal to the previously characterized Crk binding motifs in C3G.	Proline	58-65	Rap guanine nucleotide exchange factor 1	Homo sapiens	26-29
9748234-6	1998	A series of analysis with C3G deletion mutants revealed a proline-rich Cas-binding site (Ala0-Pro1-Pro2-Lys3-Pro4-Pro5-Leu6-Pro7) located NH2-terminal to the previously characterized Crk binding motifs in C3G.	Proline	58-65	BCAR1 scaffold protein, Cas family member	Homo sapiens	71-74
9748234-6	1998	A series of analysis with C3G deletion mutants revealed a proline-rich Cas-binding site (Ala0-Pro1-Pro2-Lys3-Pro4-Pro5-Leu6-Pro7) located NH2-terminal to the previously characterized Crk binding motifs in C3G.	Proline	58-65	CRK proto-oncogene, adaptor protein	Homo sapiens	183-186
9748234-6	1998	A series of analysis with C3G deletion mutants revealed a proline-rich Cas-binding site (Ala0-Pro1-Pro2-Lys3-Pro4-Pro5-Leu6-Pro7) located NH2-terminal to the previously characterized Crk binding motifs in C3G.	Proline	58-65	Rap guanine nucleotide exchange factor 1	Homo sapiens	205-208
9748234-8	1998	These results, combined with sequence alignments of proline-rich binding elements from proteins known for Cas binding, define the consensus sequence XXPXKPX which is recognized by the CasSH3 domain.	Proline	52-59	BCAR1 scaffold protein, Cas family member	Homo sapiens	106-109
9748248-6	1998	In vitro, tyrosine phosphorylation of cortactin occurs specifically within the region between the proline-rich sequence and the Src homology 3 domain.	Proline	98-105	cortactin	Homo sapiens	38-47
9748251-5	1998	By co-transfection of truncated mutants of SKAP55 and SLAP-130 as well as by using the two-hybrid selection system, we further demonstrate that the association between SLAP-130 and SKAP55 is direct and involves the Src homology 3 domain of SKAP55 and the proline-rich sequence of SLAP-130.	Proline	255-262	src kinase associated phosphoprotein 1	Homo sapiens	43-49
9748251-5	1998	By co-transfection of truncated mutants of SKAP55 and SLAP-130 as well as by using the two-hybrid selection system, we further demonstrate that the association between SLAP-130 and SKAP55 is direct and involves the Src homology 3 domain of SKAP55 and the proline-rich sequence of SLAP-130.	Proline	255-262	FYN binding protein 1	Homo sapiens	168-176
9748251-5	1998	By co-transfection of truncated mutants of SKAP55 and SLAP-130 as well as by using the two-hybrid selection system, we further demonstrate that the association between SLAP-130 and SKAP55 is direct and involves the Src homology 3 domain of SKAP55 and the proline-rich sequence of SLAP-130.	Proline	255-262	src kinase associated phosphoprotein 1	Homo sapiens	181-187
9748251-5	1998	By co-transfection of truncated mutants of SKAP55 and SLAP-130 as well as by using the two-hybrid selection system, we further demonstrate that the association between SLAP-130 and SKAP55 is direct and involves the Src homology 3 domain of SKAP55 and the proline-rich sequence of SLAP-130.	Proline	255-262	src kinase associated phosphoprotein 1	Homo sapiens	181-187
9748251-5	1998	By co-transfection of truncated mutants of SKAP55 and SLAP-130 as well as by using the two-hybrid selection system, we further demonstrate that the association between SLAP-130 and SKAP55 is direct and involves the Src homology 3 domain of SKAP55 and the proline-rich sequence of SLAP-130.	Proline	255-262	FYN binding protein 1	Homo sapiens	168-176
9758807-12	1998	S. cerevisiae strains lacking URE2 function could improve alcoholic fermentation of natural media where proline and other poorly assimilated amino acids are the major potential nitrogen source, as is the case for most fruit juices and grape musts.	Proline	104-111	glutathione peroxidase	Saccharomyces cerevisiae S288C	30-34
9742220-5	1998	By using two different forms of the dynamin proline-rich domain as affinity ligands, the binding site for MLK2-SH3 was mapped to the C-terminal region of dynamin between residues 832 and 864.	Proline	44-51	mitogen-activated protein kinase kinase kinase 10	Homo sapiens	106-110
9753294-3	1998	The DQB1 homolog in NOD mice, I-Ab(g7), encodes a histidine at codon 56 and a serine at codon 57, while all other known I-Ab alleles encode proline and aspartic acid, respectively, at these positions.	Proline	140-147	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	4-8
9751520-5	1998	The proline rich box 1 region of the GH receptor was required for hGH to stimulate tubulin polymerization indicative that this event is JAK dependent.	Proline	4-11	growth hormone receptor	Rattus norvegicus	37-48
9797470-2	1998	c-Cbl possesses a highly conserved N-terminal phosphotyrosine binding domain, a C3HC4 RING finger motif, multiple proline-rich motifs, and a number of potential tyrosine phosphorylation sites.	Proline	114-121	Cbl proto-oncogene	Homo sapiens	0-5
9765512-2	1998	This variant, termed RGS 9L, differs from the retinal form (termed RGS 9S) identified previously in that it contains a 211- (rat) or 205- (human) amino acid proline-rich domain on the carboxyl terminus.	Proline	157-164	regulator of G protein signaling 9	Homo sapiens	21-27
9819765-4	1998	According to the deduced amino acid (aa) sequence analysis, hamster MCS encoded a polypeptide of 184 aa, including a cysteine- and proline-rich domain which is the characteristic sequences of MCS, and contained 2 in-frame UGA codons for selenocysteine.	Proline	131-138	sperm mitochondria-associated cysteine-rich protein	Rattus norvegicus	68-71
9742121-1	1998	Previously, we found that the cause of autosomal dominant selective tooth agenesis in one family is a missense mutation resulting in an arginine-to-proline substitution in the homeodomain of MSX1.	Proline	148-155	msh homeobox 1	Homo sapiens	191-195
9773976-4	1998	This interaction requires the proline-rich transactivation domain of CTF1.	Proline	30-37	DNA helicase	Saccharomyces cerevisiae S288C	69-73
9808459-4	1998	A novel proline-rich "Homer ligand" (PPXXFr) is identified in group 1 mGluRs and IP3R, and these receptors coimmunoprecipitate as a complex with Homer from brain.	Proline	8-15	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-85
9765552-1	1998	We isolated two tomato (Lycopersicon esculentum) cDNA clones, tomPRO1 and tomPRO2, specifying Delta1-pyrroline-5-carboxylate synthetase (P5CS), the first enzyme of proline (Pro) biosynthesis.	Proline	164-171	delta-1-pyrroline-5-carboxylate synthase	Solanum lycopersicum	74-81
9765552-1	1998	We isolated two tomato (Lycopersicon esculentum) cDNA clones, tomPRO1 and tomPRO2, specifying Delta1-pyrroline-5-carboxylate synthetase (P5CS), the first enzyme of proline (Pro) biosynthesis.	Proline	164-171	delta-1-pyrroline-5-carboxylate synthase	Solanum lycopersicum	100-135
9765552-1	1998	We isolated two tomato (Lycopersicon esculentum) cDNA clones, tomPRO1 and tomPRO2, specifying Delta1-pyrroline-5-carboxylate synthetase (P5CS), the first enzyme of proline (Pro) biosynthesis.	Proline	164-171	delta-1-pyrroline-5-carboxylate synthase	Solanum lycopersicum	137-141
9850596-5	1998	Thrombin (5-20 U/ml) also stimulated the protein synthesis rate (assayed by [3H]proline incorporation) to 1.88-2.13 fold that of the control.	Proline	80-87	coagulation factor II, thrombin	Homo sapiens	0-8
9792099-2	1998	Analysis of the nuclear magnetic resonance (NMR) data for the sixth TB module from human fibrillin-1 has revealed the existence of two stable conformers that differ in the isomerization states of two proline residues.	Proline	200-207	fibrillin 1	Homo sapiens	89-100
9721188-10	1998	Incubation of cells labeled with radioactive proline in the presence of monensin and brefeldin A, which inhibit secretion at different sites, led to intracellular accumulation of the least phosphorylated form of rat IGFBP-1, but prevented further phosphorylation.	Proline	45-52	insulin-like growth factor binding protein 1	Rattus norvegicus	216-223
9827668-2	1998	The limited proteolysis of thyrotropin-releasing hormone (TRH) by Pyroglutamate aminopeptidase yields cyclo(His-Pro) or CHP, a new biopeptide associated with a variety of pharmacological activities, including regulation of body temperature, inhibition of prolactin secretion, and modulation of motor functions.	Proline	112-115	thyrotropin releasing hormone	Homo sapiens	27-56
9827668-2	1998	The limited proteolysis of thyrotropin-releasing hormone (TRH) by Pyroglutamate aminopeptidase yields cyclo(His-Pro) or CHP, a new biopeptide associated with a variety of pharmacological activities, including regulation of body temperature, inhibition of prolactin secretion, and modulation of motor functions.	Proline	112-115	thyrotropin releasing hormone	Homo sapiens	58-61
9748319-6	1998	Interestingly, we have demonstrated for the first time that PTP-PEST, through its first proline-rich sequence 332PPKPPR337, interacts with other members of the p130(Cas) family (Hef1 and Sin) via their SH3 domain in vitro.	Proline	88-95	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	60-68
9748319-6	1998	Interestingly, we have demonstrated for the first time that PTP-PEST, through its first proline-rich sequence 332PPKPPR337, interacts with other members of the p130(Cas) family (Hef1 and Sin) via their SH3 domain in vitro.	Proline	88-95	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	160-164
9748319-6	1998	Interestingly, we have demonstrated for the first time that PTP-PEST, through its first proline-rich sequence 332PPKPPR337, interacts with other members of the p130(Cas) family (Hef1 and Sin) via their SH3 domain in vitro.	Proline	88-95	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	178-182
9748319-10	1998	Furthermore, the Cas-like molecules Hef1 and Sin associate via their SH3 domains with a proline-rich motif found on PTP-PEST, suggesting the possibility that PTP-PEST could be a general modulator of the Cas family of proteins.	Proline	88-95	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	36-40
9748319-10	1998	Furthermore, the Cas-like molecules Hef1 and Sin associate via their SH3 domains with a proline-rich motif found on PTP-PEST, suggesting the possibility that PTP-PEST could be a general modulator of the Cas family of proteins.	Proline	88-95	embryonal Fyn-associated substrate	Homo sapiens	45-48
9748319-10	1998	Furthermore, the Cas-like molecules Hef1 and Sin associate via their SH3 domains with a proline-rich motif found on PTP-PEST, suggesting the possibility that PTP-PEST could be a general modulator of the Cas family of proteins.	Proline	88-95	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	116-124
9748319-10	1998	Furthermore, the Cas-like molecules Hef1 and Sin associate via their SH3 domains with a proline-rich motif found on PTP-PEST, suggesting the possibility that PTP-PEST could be a general modulator of the Cas family of proteins.	Proline	88-95	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	158-166
9737862-0	1998	Identification of a meander region proline residue critical for heme binding to cytochrome P450: implications for the catalytic function of human CYP4B1.	Proline	35-42	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	146-152
9737862-1	1998	Alignment of xenobiotic-metabolizing P450 protein sequences highlights an invariant proline residue in the meander region two amino acids N-terminal to the distal arginine of the putative ERR triad thought to be important for heme binding.	Proline	84-91	solute carrier family 7 member 1	Homo sapiens	188-191
9737862-4	1998	Mutation of the corresponding proline in rabbit CYP4B1 (Pro422 --&gt; Ser) abolished heme incorporation.	Proline	30-37	cytochrome P450 4B1	Oryctolagus cuniculus	48-54
9737862-5	1998	Membrane preparations of human CYP4B1(Pro) and rabbit CYP4B1(Pro), but not the corresponding CYP4B1(Ser) variants, supported lauric acid hydroxylation preferentially at the omega-position.	Proline	38-41	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	31-37
9737862-5	1998	Membrane preparations of human CYP4B1(Pro) and rabbit CYP4B1(Pro), but not the corresponding CYP4B1(Ser) variants, supported lauric acid hydroxylation preferentially at the omega-position.	Proline	61-64	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	31-37
9737862-5	1998	Membrane preparations of human CYP4B1(Pro) and rabbit CYP4B1(Pro), but not the corresponding CYP4B1(Ser) variants, supported lauric acid hydroxylation preferentially at the omega-position.	Proline	61-64	cytochrome P450 4B1	Oryctolagus cuniculus	54-60
9737862-5	1998	Membrane preparations of human CYP4B1(Pro) and rabbit CYP4B1(Pro), but not the corresponding CYP4B1(Ser) variants, supported lauric acid hydroxylation preferentially at the omega-position.	Proline	61-64	cytochrome P450 4B1	Oryctolagus cuniculus	54-60
9742979-1	1998	BACKGROUND: A polymorphism at codon 72 of the human tumour-suppressor gene, p53, results in translation to either arginine or proline.	Proline	126-133	tumor protein p53	Homo sapiens	76-79
9764820-8	1998	Furthermore, Dok-R is constitutively bound to Crk presumably through the proline rich tail of Dok-R.	Proline	73-80	docking protein 2	Mus musculus	13-18
9764820-8	1998	Furthermore, Dok-R is constitutively bound to Crk presumably through the proline rich tail of Dok-R.	Proline	73-80	v-crk avian sarcoma virus CT10 oncogene homolog	Mus musculus	46-49
9764820-8	1998	Furthermore, Dok-R is constitutively bound to Crk presumably through the proline rich tail of Dok-R.	Proline	73-80	docking protein 2	Mus musculus	94-99
9762411-0	1998	Spin trapping for nitric oxide produced in LPS-treated mouse using various new dithiocarbamate iron complexes having substituted proline and serine moiety.	Proline	129-136	spindlin 1	Mus musculus	0-4
9813110-11	1998	A deletion mutant analysis of cortactin-A and CBP90 revealed that the SH3 domain of cortactin-A was able to bind to the proline-rich region of CBP90.	Proline	120-127	cortactin binding protein 2	Rattus norvegicus	46-51
9724657-2	1998	Structural and kinetic results suggest that UDG binds, kinks and compresses the DNA backbone with a "Ser-Pro pinch" and scans the minor groove for damage.	Proline	105-108	uracil DNA glycosylase	Homo sapiens	44-47
9813110-11	1998	A deletion mutant analysis of cortactin-A and CBP90 revealed that the SH3 domain of cortactin-A was able to bind to the proline-rich region of CBP90.	Proline	120-127	cortactin	Rattus norvegicus	84-93
9813110-9	1998	The deduced amino acid sequence of CBP90 had no significant similarity to any other protein, but it had a proline-rich domain at the C-terminal region.	Proline	106-113	cortactin binding protein 2	Rattus norvegicus	35-40
9700202-6	1998	This interaction is mediated by huntingtin"s proline-rich region and is enhanced by lengthening the adjacent glutamine tract.	Proline	45-52	huntingtin	Homo sapiens	32-42
9813110-11	1998	A deletion mutant analysis of cortactin-A and CBP90 revealed that the SH3 domain of cortactin-A was able to bind to the proline-rich region of CBP90.	Proline	120-127	cortactin	Rattus norvegicus	30-39
9813110-11	1998	A deletion mutant analysis of cortactin-A and CBP90 revealed that the SH3 domain of cortactin-A was able to bind to the proline-rich region of CBP90.	Proline	120-127	cortactin binding protein 2	Rattus norvegicus	143-148
9798343-9	1998	Based on the comparative analysis among the amino acid sequences of the beta 1-domain of the HLA-DQB1*03 alleles, proline at residue 55 was suggested to be important as a common amino acid for determination of the susceptibility to GPP.	Proline	114-121	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	93-101
9745456-1	1998	We describe a patient with Blomstrand chondrodysplasia, a lethal genetic disorder characterized by extremely advanced endochondral bone maturation, in whom a homozygous missense mutation is present in the gene coding for the PTH/PTHrP receptor that leads to the substitution of a proline for a leucine in the N-terminal portion of the receptor (P132L).	Proline	280-287	parathyroid hormone 1 receptor	Homo sapiens	225-243
9712905-9	1998	The CRHSP-24 protein is 147 amino acids in length, is composed of nearly 14% proline, and is phosphorylated entirely on serine residues.	Proline	77-84	calcium regulated heat stable protein 1	Rattus norvegicus	4-12
9710614-0	1998	Identification of a proline-rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin-mediated adhesion and activation of phosphoinositide 3-kinase.	Proline	20-27	CD2 molecule	Homo sapiens	49-52
9710614-0	1998	Identification of a proline-rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin-mediated adhesion and activation of phosphoinositide 3-kinase.	Proline	20-27	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	144-169
9710614-6	1998	A proline-rich sequence, K-G-P-P-L-P (amino acids 299 to 305), is essential for CD2-mediated regulation of beta1 integrin activity.	Proline	2-9	CD2 molecule	Homo sapiens	80-83
9710614-6	1998	A proline-rich sequence, K-G-P-P-L-P (amino acids 299 to 305), is essential for CD2-mediated regulation of beta1 integrin activity.	Proline	2-9	integrin subunit beta 1	Homo sapiens	107-121
9710614-10	1998	Mutation of the proline residues in the K-G-P-P-L-P motif to alanines prevented CD2-mediated activation of integrin function and PI 3-K activity but not mitogen-activated protein (MAP) kinase activity.	Proline	16-23	CD2 molecule	Homo sapiens	80-83
9710614-12	1998	These studies identify a proline-rich sequence in CD2 critical for PI 3-K-dependent regulation of beta1 integrin adhesion by CD2.	Proline	25-32	CD2 molecule	Homo sapiens	50-53
9710614-12	1998	These studies identify a proline-rich sequence in CD2 critical for PI 3-K-dependent regulation of beta1 integrin adhesion by CD2.	Proline	25-32	integrin subunit beta 1	Homo sapiens	98-112
9710614-12	1998	These studies identify a proline-rich sequence in CD2 critical for PI 3-K-dependent regulation of beta1 integrin adhesion by CD2.	Proline	25-32	CD2 molecule	Homo sapiens	125-128
9724750-2	1998	In yeast, this bridging involves interactions between the WW domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein, BBP.	Proline	104-111	Prp40p	Saccharomyces cerevisiae S288C	92-97
9724750-2	1998	In yeast, this bridging involves interactions between the WW domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein, BBP.	Proline	104-111	splicing factor 1	Mus musculus	160-163
9731200-3	1998	When the full-length cDNA of HdynIV was sequenced, it showed that HdynIV"s carboxyl terminal lacks a proline-rich domain that can bind to Gsk-3 beta.	Proline	101-108	dynamin 1 like	Homo sapiens	29-35
9731200-3	1998	When the full-length cDNA of HdynIV was sequenced, it showed that HdynIV"s carboxyl terminal lacks a proline-rich domain that can bind to Gsk-3 beta.	Proline	101-108	dynamin 1 like	Homo sapiens	66-72
9722619-5	1998	While interactions of neurofascin with F11 are only slightly modulated, binding to axonin-1 and TN-R is strongly regulated by alternatively spliced stretches located in the NH2-terminal half, and by the proline-alanine-threonine-rich segment.	Proline	203-210	tenascin R	Homo sapiens	96-100
9707426-6	1998	To explain this discrepancy, evidence is given for a proline-rich domain-mediated cellular activation of p53 DNA binding.	Proline	53-60	tumor protein p53	Homo sapiens	105-108
9707426-0	1998	The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression.	Proline	28-35	tumor protein p53	Homo sapiens	24-27
9707426-0	1998	The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression.	Proline	28-35	tumor protein p53 inducible protein 3	Homo sapiens	114-118
9707426-2	1998	The human p53 proline-rich domain localized between amino acids 64 and 92 has been reported to be necessary for efficient growth suppression.	Proline	14-21	tumor protein p53	Homo sapiens	10-13
9708987-5	1998	At the monomer-monomer interfaces, the B28 Pro --&gt; Asp mutation leads to increased conformational flexibility in the B chain C termini, resulting in the loss of important intermolecular van der Waals contacts, thus explaining the monomeric character of B28 Asp insulin.	Proline	43-46	MIS18 kinetochore protein A	Homo sapiens	39-42
9708987-5	1998	At the monomer-monomer interfaces, the B28 Pro --&gt; Asp mutation leads to increased conformational flexibility in the B chain C termini, resulting in the loss of important intermolecular van der Waals contacts, thus explaining the monomeric character of B28 Asp insulin.	Proline	43-46	MIS18 kinetochore protein A	Homo sapiens	256-259
9708987-5	1998	At the monomer-monomer interfaces, the B28 Pro --&gt; Asp mutation leads to increased conformational flexibility in the B chain C termini, resulting in the loss of important intermolecular van der Waals contacts, thus explaining the monomeric character of B28 Asp insulin.	Proline	43-46	insulin	Homo sapiens	264-271
9694860-6	1998	Like BRO1, p164(PTP-TD14) contains a proline-rich region with two putative SH3-domain binding sites.	Proline	37-44	protein tyrosine phosphatase, non-receptor type 23	Rattus norvegicus	16-24
9721727-7	1998	Expression of the proline-rich domain of SOS (SOS-PRO), which inhibits SOS interaction with p21ras, also attenuated nociceptin (OFQ)-stimulated MAP kinase activation.	Proline	18-25	prepronociceptin	Cricetulus griseus	116-126
9705283-1	1998	PAX6 is a transcription factor with two DNA-binding domains (paired box and homeobox) and a proline-serine-threonine (PST)-rich transactivation domain.	Proline	92-99	paired box 6	Homo sapiens	0-4
9707624-9	1998	Molecular analysis of the HSD11B2 gene of this patient showed a homozygous C--&gt;T transition in the second nucleotide of codon 227, resulting in a substitution of proline with leucine (P227L).	Proline	165-172	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	26-33
9712717-6	1998	Both the human homologue and mouse MmTRA1b protein but not MmTRA1a protein possess a proline-rich domain at the N-terminal end.	Proline	85-92	phospholipid scramblase 1	Mus musculus	35-42
9712732-6	1998	The interaction of this extended PLCgamma1 SH3 domain fusion protein with Cbl was shown to depend entirely upon the interaction of the domain with a proline-rich motif in Cbl, ruling out the possibility that amino acids adjacent to the core SH3 domain of PLCgamma1 provide independent Cbl binding.	Proline	149-156	phospholipase C gamma 1	Homo sapiens	33-42
9712732-6	1998	The interaction of this extended PLCgamma1 SH3 domain fusion protein with Cbl was shown to depend entirely upon the interaction of the domain with a proline-rich motif in Cbl, ruling out the possibility that amino acids adjacent to the core SH3 domain of PLCgamma1 provide independent Cbl binding.	Proline	149-156	Cbl proto-oncogene	Homo sapiens	74-77
9705210-8	1998	The bactericidal activity of the proline-rich repeat sequence suggests that bacterial colonization, facilitated by the adsorbed salivary mucins on tooth surface, could be partly controlled and cleared by proteolytically degraded proline-rich peptides of MG2 in saliva before the colonized organisms turn into pathogens.	Proline	33-40	mucin 7, secreted	Homo sapiens	254-257
9705210-8	1998	The bactericidal activity of the proline-rich repeat sequence suggests that bacterial colonization, facilitated by the adsorbed salivary mucins on tooth surface, could be partly controlled and cleared by proteolytically degraded proline-rich peptides of MG2 in saliva before the colonized organisms turn into pathogens.	Proline	229-236	mucin 7, secreted	Homo sapiens	254-257
9746352-1	1998	The vitellogenin-binding protein (VBP) is a member of the proline and acidic-region rich (PAR) family of bZip transcription factors.	Proline	58-65	TEF, PAR bZIP transcription factor	Gallus gallus	4-32
9746352-1	1998	The vitellogenin-binding protein (VBP) is a member of the proline and acidic-region rich (PAR) family of bZip transcription factors.	Proline	58-65	TEF, PAR bZIP transcription factor	Gallus gallus	34-37
9694849-2	1998	Nck links, via its SH2 domain, tyrosine-phosphorylated receptors to effector proteins that contain SH3-binding proline-rich sequences.	Proline	111-118	NCK adaptor protein 1	Homo sapiens	0-3
9694876-0	1998	Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction.	Proline	82-89	growth factor receptor bound protein 2	Homo sapiens	0-4
9694876-0	1998	Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction.	Proline	82-89	CD28 molecule	Homo sapiens	45-49
9685426-2	1998	LTBP-2 consists mainly of domains of 8-cysteine and EGF-like repeats linked by proline-rich regions.	Proline	79-86	latent-transforming growth factor beta-binding protein 2	Cricetulus griseus	0-6
9685402-0	1998	A conserved proline in the hsp90 binding region of the glucocorticoid receptor is required for hsp90 heterocomplex stabilization and receptor signaling.	Proline	12-19	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	27-32
9685426-9	1998	Processing sites were localized by amino acid sequencing to proline-rich regions at the N-terminal part of LTBP-2, suggesting that the matrix binding sites locate to the N-terminal approximately 500 amino acids of LTBP-2.	Proline	60-67	latent-transforming growth factor beta-binding protein 2	Cricetulus griseus	107-113
9685402-0	1998	A conserved proline in the hsp90 binding region of the glucocorticoid receptor is required for hsp90 heterocomplex stabilization and receptor signaling.	Proline	12-19	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	95-100
9685402-10	1998	Our results demonstrate that Pro-643 plays a critical role in both stabilizing the receptor.hsp90 complex and in permitting an efficient nuclear translocation and, thus, support the concept that the chaperone is an integral component of the steroid-receptor signaling pathway.	Proline	29-32	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	92-97
9705840-1	1998	TESK1 (testis-specific protein kinase 1) is a serine/threonine kinase, with a unique structure composed of an N-terminal protein kinase domain and a C-terminal proline-rich domain.	Proline	160-167	testis associated actin remodelling kinase 1	Rattus norvegicus	0-5
9705840-1	1998	TESK1 (testis-specific protein kinase 1) is a serine/threonine kinase, with a unique structure composed of an N-terminal protein kinase domain and a C-terminal proline-rich domain.	Proline	160-167	testis associated actin remodelling kinase 1	Rattus norvegicus	7-39
9689109-6	1998	The zf9 nucleotide sequence predicts a member of the Kruppel-like family with a unique N-terminal domain rich in serine-proline clusters and leucines.	Proline	120-127	Kruppel-like factor 6	Rattus norvegicus	4-7
9687529-7	1998	Truncation mutants indicate that the induction of the apoptotic response relies mainly on 69 amino acids within Blimp-1"s proline-rich domain.	Proline	122-129	PR domain containing 1, with ZNF domain	Mus musculus	112-119
9727514-6	1998	The four patients with congenital cataracts all had mutations in the C-terminal proline-serine-threonine (PST)-rich domain of the PAX6 protein.	Proline	80-87	paired box 6	Homo sapiens	130-134
9692984-0	1998	Trans-cis isomerization of proline 22 in bovine prothrombin fragment 1: a surprising result of structural characterization.	Proline	27-34	coagulation factor II, thrombin	Bos taurus	48-59
9675168-1	1998	Titin, a 1-microm-long protein found in striated muscle myofibrils, possesses unique elastic and extensibility properties in its I-band region, which is largely composed of a PEVK region (70% proline, glutamic acid, valine, and lysine residue) and seven-strand beta-sandwich immunoglobulin-like (Ig) domains.	Proline	192-199	titin	Homo sapiens	0-5
9722928-2	1998	The mature peptide has nine conserved cysteines and a conserved proline (position 36) and glycine (position 46), all characteristics of TGF-beta superfamily molecules.	Proline	64-71	transforming growth factor beta-1 proprotein	Oncorhynchus mykiss	136-144
9685731-8	1998	Primary structure analysis of GBF revealed a C2H2 Kruppel-type zinc finger at its C-terminus, and putative acidic and proline-rich domains at its N-terminus.	Proline	118-125	Kruppel like factor 6	Homo sapiens	30-33
9787459-8	1998	In contrast to the wild-type plants, dehydration-induced accumulation of proline was highly suppressed in the aba2-2 mutant plants while that of leucine and isoleucine accumulated.	Proline	73-80	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	110-116
9658131-2	1998	Oligomerization, intact DNA-binding, replication protein A-binding, and proline-rich domains of the p53 protein were essential for efficient inhibition, while the N-terminal transcriptional activation and C-terminal regulatory domains were dispensable for the suppressor activity of the p53 protein.	Proline	72-79	tumor protein p53	Homo sapiens	100-103
9717837-5	1998	AIRE is expressed in thymus, lymph nodes, and fetal liver and encodes a protein containing motifs suggestive of a transcriptional regulator, including two zinc finger motifs (PHD finger), a proline-rich region, and three LXXLL motifs.	Proline	190-197	autoimmune regulator	Homo sapiens	0-4
9697697-1	1998	p130Cas (Cas), the protein encoded by the Crkas gene (also known as Cas), is an adaptor molecule with a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich region.	Proline	203-210	breast cancer anti-estrogen resistance 1	Mus musculus	0-7
9697697-1	1998	p130Cas (Cas), the protein encoded by the Crkas gene (also known as Cas), is an adaptor molecule with a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich region.	Proline	203-210	breast cancer anti-estrogen resistance 1	Mus musculus	4-7
9697697-1	1998	p130Cas (Cas), the protein encoded by the Crkas gene (also known as Cas), is an adaptor molecule with a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich region.	Proline	203-210	breast cancer anti-estrogen resistance 1	Mus musculus	42-47
9697697-1	1998	p130Cas (Cas), the protein encoded by the Crkas gene (also known as Cas), is an adaptor molecule with a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich region.	Proline	203-210	breast cancer anti-estrogen resistance 1	Mus musculus	9-12
9710239-1	1998	Synaptojanin1, the major constitutively active PtdInsP3 5-phosphatase activity in rat brain, is one of two closely related proteins both extensively spliced in their C-terminal proline rich domain.	Proline	177-184	synaptojanin 1	Rattus norvegicus	0-13
9716158-11	1998	Nevertheless, the lack of effect of R2 on thrombin-induced platelet activation suggests that proline 280 is important for thrombin interaction with GPIb.	Proline	93-100	coagulation factor II, thrombin	Homo sapiens	122-130
9705913-4	1998	Indeed, Nef contains a proline-rich motif implicated in the binding to the Src-like tyrosine kinase Hck and also to a Ser/Thr kinase of molecular weight 62 kDa.	Proline	23-30	S100 calcium binding protein B	Homo sapiens	8-11
9705913-4	1998	Indeed, Nef contains a proline-rich motif implicated in the binding to the Src-like tyrosine kinase Hck and also to a Ser/Thr kinase of molecular weight 62 kDa.	Proline	23-30	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	100-103
9705913-8	1998	Both the proline motif and phosphorylation of Nef on tyrosine residue were proposed to account for these interactions.	Proline	9-16	S100 calcium binding protein B	Homo sapiens	46-49
9677429-0	1998	The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells.	Proline	9-16	mitogen-activated protein kinase kinase 1	Homo sapiens	4-8
9677429-0	1998	The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells.	Proline	9-16	mitogen-activated protein kinase 3	Homo sapiens	107-111
9677429-0	1998	The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells.	Proline	9-16	mitogen-activated protein kinase 1	Homo sapiens	116-120
9677429-1	1998	MEK1 and MEK2 contain a proline-rich insert not present in any other known MEK (MAP (mitogen-activated protein)/ERK (extracellular signal-regulated kinase) kinase) family members.	Proline	24-31	mitogen-activated protein kinase kinase 1	Homo sapiens	0-4
9677429-1	1998	MEK1 and MEK2 contain a proline-rich insert not present in any other known MEK (MAP (mitogen-activated protein)/ERK (extracellular signal-regulated kinase) kinase) family members.	Proline	24-31	mitogen-activated protein kinase kinase 2	Homo sapiens	9-13
9677429-1	1998	MEK1 and MEK2 contain a proline-rich insert not present in any other known MEK (MAP (mitogen-activated protein)/ERK (extracellular signal-regulated kinase) kinase) family members.	Proline	24-31	mitogen-activated protein kinase kinase 7	Homo sapiens	0-3
9677429-6	1998	The proline-rich insert enhanced the ability of an otherwise equally active MEK1 protein to regulate endogenous ERKs in mammalian cells.	Proline	4-11	mitogen-activated protein kinase kinase 1	Homo sapiens	76-80
9671742-6	1998	ZNF217 is predicted to encode alternately spliced, Kruppel-like transcription factors of 1,062 and 1,108 aa, each having a DNA-binding domain (eight C2H2 zinc fingers) and a proline-rich transcription activation domain.	Proline	174-181	zinc finger protein 217	Homo sapiens	0-6
9677429-6	1998	The proline-rich insert enhanced the ability of an otherwise equally active MEK1 protein to regulate endogenous ERKs in mammalian cells.	Proline	4-11	mitogen-activated protein kinase 3	Homo sapiens	112-116
9660787-7	1998	A second series of daughter ions showed that Pro-143 was hydroxylated and derivatized with a potentially linear pentasaccharide, Hex--&gt;Hex--&gt;Fuc--&gt;Hex--&gt;HexNAc--&gt;(HyPro).	Proline	45-48	hematopoietically expressed homeobox	Homo sapiens	129-132
9660787-7	1998	A second series of daughter ions showed that Pro-143 was hydroxylated and derivatized with a potentially linear pentasaccharide, Hex--&gt;Hex--&gt;Fuc--&gt;Hex--&gt;HexNAc--&gt;(HyPro).	Proline	45-48	hematopoietically expressed homeobox	Homo sapiens	138-141
9660787-7	1998	A second series of daughter ions showed that Pro-143 was hydroxylated and derivatized with a potentially linear pentasaccharide, Hex--&gt;Hex--&gt;Fuc--&gt;Hex--&gt;HexNAc--&gt;(HyPro).	Proline	45-48	hematopoietically expressed homeobox	Homo sapiens	138-141
9668096-3	1998	The proline-rich domain of Drosophila dynamin was used to identify and purify a third component of the endocytosis zones.	Proline	4-11	shibire	Drosophila melanogaster	38-45
9665726-0	1998	Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor.	Proline	51-58	macrophage migration inhibitory factor	Homo sapiens	109-136
9665726-4	1998	MIF also has an amino-terminal proline that has been implicated as a catalytic group in the MIF-catalyzed reaction.	Proline	31-38	macrophage migration inhibitory factor	Homo sapiens	0-3
9649424-3	1998	The three-dimensional structure of MIF is unlike that of any other cytokine, but bears striking resemblance to three microbial enzymes, two of which possess an N-terminal proline that serves as a catalytic base.	Proline	171-178	macrophage migration inhibitory factor	Homo sapiens	35-38
9651361-7	1998	The HCV core protein-binding domain was located within amino acid residues 250 to 392, which contain the three proline-rich domains, of hnRNP K.	Proline	111-118	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	136-143
9695975-2	1998	We predicted that the residue replacement of Leu with Pro of the mutant enzyme would account for the b5R deficiency in the patient.	Proline	54-57	cytochrome b5 reductase 3	Homo sapiens	101-104
9710993-2	1998	The natural sequence in human insulin at these positions is proline at B28 and lysine at B29.	Proline	60-67	insulin	Homo sapiens	30-37
9649424-4	1998	Human MIF also possesses an N-terminal proline (Pro-1) that is invariant among all known homologues.	Proline	39-46	macrophage migration inhibitory factor	Homo sapiens	6-9
9649424-4	1998	Human MIF also possesses an N-terminal proline (Pro-1) that is invariant among all known homologues.	Proline	39-46	lamin A/C	Homo sapiens	48-53
9649424-5	1998	Multiple sequence alignment of these MIF homologues reveals additional invariant residues that span the entire polypeptide but are in close proximity to the N-terminal proline in the folded protein.	Proline	168-175	macrophage migration inhibitory factor	Homo sapiens	37-40
9693042-3	1998	Human and rat LRP3 cDNAs encode a 770-amino-acid type 1 membrane protein with the following regions: a putative signal sequence, two isoleucine/leucine/valine-rich regions with an RGD sequence, two ligand-binding repeat regions, a putative transmembrane region, and a proline-rich cytoplasmic region with a tyrosine-based internalization signal.	Proline	268-275	LDL receptor related protein 3	Rattus norvegicus	14-18
9675061-3	1998	We have now improved the expression of TP2 over fivefold by (1) optimizing the codons for lysine, arginine, proline, leucine, glycine, valine, threonine, alanine, and tyrosine and (2) by engineering the vector-encoded 5" UTR.	Proline	108-115	transition protein 2	Rattus norvegicus	39-42
9701039-0	1998	CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail.	Proline	79-86	Cd2 molecule	Rattus norvegicus	0-3
9701039-0	1998	CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail.	Proline	79-86	IL2-inducible T-cell kinase	Rattus norvegicus	58-61
9701039-0	1998	CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail.	Proline	79-86	Cd2 molecule	Rattus norvegicus	109-112
9621042-2	1998	Nef proteins from HIV type 1 (HIV-1), HIV-2, and SIV contain a proline-Xaa-Xaa-proline (PxxP) motif.	Proline	63-70	Nef	Human immunodeficiency virus 1	0-3
9690565-2	1998	Previously reported EBNA-1 C-terminal region amino acid sequence variations include five subtypes based on the amino acid at codon 487: Prototype (P)-ala, which is found in the B95.8-derived prototype virus; P-thr; Variant (V)-pro; V-leu; and V-val.	Proline	191-194	EBNA-1	Human gammaherpesvirus 4	20-26
9693037-11	1998	The amino-terminal regions of the RTN2-A and RTN2-B proteins are rich in negatively charged residues and in proline and serine residues and contain multiple potential phosphorylation sites.	Proline	108-115	reticulon 2	Homo sapiens	34-38
9693037-11	1998	The amino-terminal regions of the RTN2-A and RTN2-B proteins are rich in negatively charged residues and in proline and serine residues and contain multiple potential phosphorylation sites.	Proline	108-115	reticulon 2	Homo sapiens	45-49
9636231-5	1998	Plants with mutations at the eskimo1 (esk1) locus accumulated high levels of proline, a compatible osmolyte, but did not exhibit constitutively increased expression of several cold-regulated genes involved in freezing tolerance.	Proline	77-84	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	29-36
9716247-0	1998	Azaproline as a beta-turn-inducer residue opposed to proline.	Proline	3-10	amyloid beta precursor protein	Homo sapiens	14-20
9632734-3	1998	The N-terminal region of the largest ST5 protein, p126, contains two proline-rich sequences, PR1 and PR2, with consensus motifs similar to Src homology 3 (SH3) binding regions and to mitogen-activated protein kinase (MAPK) phosphorylation sites.	Proline	69-76	DENN domain containing 2B	Homo sapiens	37-40
9632734-3	1998	The N-terminal region of the largest ST5 protein, p126, contains two proline-rich sequences, PR1 and PR2, with consensus motifs similar to Src homology 3 (SH3) binding regions and to mitogen-activated protein kinase (MAPK) phosphorylation sites.	Proline	69-76	DENN domain containing 2B	Homo sapiens	50-54
9632736-2	1998	The p70 S6 kinase is activated by diverse stimuli through a multisite phosphorylation directed at three separate domains as follows: a cluster of (Ser/Thr) Pro sites in an autoinhibitory segment in the noncatalytic carboxyl-terminal tail; Thr-252 in the activation loop of the catalytic domain; and Ser-394 and Thr-412 in a segment immediately carboxyl-terminal to the catalytic domain.	Proline	156-159	ubiquitin associated and SH3 domain containing B	Homo sapiens	4-7
9636231-5	1998	Plants with mutations at the eskimo1 (esk1) locus accumulated high levels of proline, a compatible osmolyte, but did not exhibit constitutively increased expression of several cold-regulated genes involved in freezing tolerance.	Proline	77-84	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	38-42
9636231-6	1998	RNA gel blot analysis suggested that proline accumulation in esk1 plants was mediated by regulation of transcript levels of genes involved in proline synthesis and degradation.	Proline	37-44	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	61-65
9636231-6	1998	RNA gel blot analysis suggested that proline accumulation in esk1 plants was mediated by regulation of transcript levels of genes involved in proline synthesis and degradation.	Proline	142-149	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	61-65
9624159-4	1998	ACLP is a nonnuclear protein that contains a signal peptide, a lysine- and proline-rich 11-amino acid repeating motif, a discoidin-like domain, and a C-terminal domain with 39% identity to carboxypeptidase E.	Proline	75-82	AE binding protein 1	Mus musculus	0-4
9624128-16	1998	A single proline-rich domain (residues 357-371) was found to bind p67(phox) in the absence and presence of lithium dodecyl sulfate.	Proline	9-16	CD33 molecule	Homo sapiens	66-69
9624152-4	1998	Substitution of the three amino acids in p38 by those in SAPK3/4 (Thr-106, His-107, and Leu-108 to Met, Pro, and Phe) resulted in decreased 125I-SB 206718 cross-linking and loss of inhibition by SB 203580.	Proline	104-107	mitogen-activated protein kinase 14	Homo sapiens	41-44
9642120-0	1998	Identification and characterization of a new human gene encoding a small protein with high homology to the proline-rich region of the SH3BGR gene.	Proline	107-114	SH3 domain binding glutamate rich protein	Homo sapiens	134-140
9624152-4	1998	Substitution of the three amino acids in p38 by those in SAPK3/4 (Thr-106, His-107, and Leu-108 to Met, Pro, and Phe) resulted in decreased 125I-SB 206718 cross-linking and loss of inhibition by SB 203580.	Proline	104-107	mitogen-activated protein kinase 12	Homo sapiens	57-62
9642120-2	1998	The SH3BGRL gene encodes for a small protein of 114 amino acids, sharing 60% identity and 84% conservation on the amino acid level with the middle, proline-rich region of the SH3BGR gene and containing a similar SH3 (Scr homology 3) binding motif.	Proline	148-155	SH3 domain binding glutamate rich protein like	Homo sapiens	4-11
9642120-2	1998	The SH3BGRL gene encodes for a small protein of 114 amino acids, sharing 60% identity and 84% conservation on the amino acid level with the middle, proline-rich region of the SH3BGR gene and containing a similar SH3 (Scr homology 3) binding motif.	Proline	148-155	SH3 domain binding glutamate rich protein	Homo sapiens	4-10
9642120-5	1998	The SH3BGR gene and its homologue, SH3BGRL, could be members of a new family of genes containing a highly conserved proline-rich functional domain.	Proline	116-123	SH3 domain binding glutamate rich protein	Homo sapiens	4-10
9642120-5	1998	The SH3BGR gene and its homologue, SH3BGRL, could be members of a new family of genes containing a highly conserved proline-rich functional domain.	Proline	116-123	SH3 domain binding glutamate rich protein like	Homo sapiens	35-42
9614117-2	1998	These Ser/Thr sites are immediately followed by proline, a motif that is commonly seen in the substrates of cyclin-dependent kinases (Cdk) and mitogen-activated protein kinases.	Proline	48-55	cyclin dependent kinase 1	Homo sapiens	134-137
9622551-1	1998	The dipeptidyl peptidase IV (DPP IV) activity of CD26 is characterized by its post-proline-cleaving capacity that plays an important but not yet understood role in biological processes.	Proline	83-90	dipeptidyl peptidase 4	Homo sapiens	4-27
9669312-2	1998	M6b-2 differs from the previously published M6b by a novel 40-amino acid insertion which is characterised by a high proline content, two casein kinase, and one tyrosine kinase consensus sequences.	Proline	116-123	glycoprotein M6B	Homo sapiens	0-3
9669312-2	1998	M6b-2 differs from the previously published M6b by a novel 40-amino acid insertion which is characterised by a high proline content, two casein kinase, and one tyrosine kinase consensus sequences.	Proline	116-123	glycoprotein M6B	Homo sapiens	44-47
9635426-3	1998	The CED-6 protein contains a phosphotyrosine binding domain at its N terminus and a proline/serine-rich region in its C-terminal half.	Proline	84-91	Cell death protein 6	Caenorhabditis elegans	4-9
9622512-9	1998	Our data suggest that the two ProRS groups may reflect coadaptations needed to accommodate changes in the operational RNA code for proline.	Proline	131-138	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	30-35
9603925-3	1998	This interaction seems to be mediated by the SH3 domain of Fyn and a proline-rich sequence located in the cytoplasmic domain of CD43.	Proline	69-76	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-62
9603925-3	1998	This interaction seems to be mediated by the SH3 domain of Fyn and a proline-rich sequence located in the cytoplasmic domain of CD43.	Proline	69-76	sialophorin	Homo sapiens	128-132
9632165-5	1998	This novel PIT1 mutation results in a proline to leucine substitution (P14L).	Proline	38-45	POU class 1 homeobox 1	Homo sapiens	11-15
9622551-1	1998	The dipeptidyl peptidase IV (DPP IV) activity of CD26 is characterized by its post-proline-cleaving capacity that plays an important but not yet understood role in biological processes.	Proline	83-90	dipeptidyl peptidase 4	Homo sapiens	29-35
9622551-1	1998	The dipeptidyl peptidase IV (DPP IV) activity of CD26 is characterized by its post-proline-cleaving capacity that plays an important but not yet understood role in biological processes.	Proline	83-90	dipeptidyl peptidase 4	Homo sapiens	49-53
9622551-3	1998	Taking into account the substrate specificity of DPP IV for P2-P1&gt;&lt;-P1" cleavage, we have designed and synthesized cyclopeptides c[(alphaH2N+)-Lys-Pro-Aba-(6-CH2-S+R2)-Glyn] 2TFA- (Aba = 3-aminobenzoic acid, R = alkyl) possessing a proline at the P1 position and a lysine in the P2 position, which allows the closing of the cycle on its side chain.	Proline	238-245	dipeptidyl peptidase 4	Homo sapiens	49-55
9657379-3	1998	Here we report that the lack of I- transport activity in T354P NIS generated by site-directed mutagenesis, is not due to a structural change induced by proline, but rather to the absence of a hydroxyl group at the beta-carbon of the amino acid residue at position 354.	Proline	152-159	solute carrier family 5 member 5	Homo sapiens	63-66
9652798-1	1998	The prognostic value of the mutation of the p53 tumor suppressor gene in non-small cell lung carcinomas (NSCLC) is controversial and a polymorphism of the p53 gene at codon 72 consisting of two alleles, arginine (Arg) and proline (Pro), has been reported to be associated with the incidence of smoking-related NSCLC.	Proline	222-229	tumor protein p53	Homo sapiens	155-158
9652798-1	1998	The prognostic value of the mutation of the p53 tumor suppressor gene in non-small cell lung carcinomas (NSCLC) is controversial and a polymorphism of the p53 gene at codon 72 consisting of two alleles, arginine (Arg) and proline (Pro), has been reported to be associated with the incidence of smoking-related NSCLC.	Proline	231-234	tumor protein p53	Homo sapiens	155-158
9677011-1	1998	Insulin lispro is a newly developed analogue of human insulin where the positions of the amino acids lysine and proline have been switched at the end of the B chain of the insulin molecule.	Proline	112-119	insulin	Homo sapiens	0-7
9677011-1	1998	Insulin lispro is a newly developed analogue of human insulin where the positions of the amino acids lysine and proline have been switched at the end of the B chain of the insulin molecule.	Proline	112-119	insulin	Homo sapiens	54-61
9677011-1	1998	Insulin lispro is a newly developed analogue of human insulin where the positions of the amino acids lysine and proline have been switched at the end of the B chain of the insulin molecule.	Proline	112-119	insulin	Homo sapiens	172-179
9677011-2	1998	Insulin lispro with lysine at position B28 and proline at position B29 has a weaker tendency for self-association than human insulin.	Proline	47-54	insulin	Homo sapiens	125-132
9626142-2	1998	Here, we describe seven children with GH, PRL, and TSH deficiency from three, reportedly unrelated, Middle Eastern families, harboring a newly recognized Pro- > Ser recessive mutation in codon 239 of the Pit-1 gene.	Proline	154-157	prolactin	Homo sapiens	42-45
9692213-2	1998	We found that CUA-1 with Cys-Pro-Cys to Cys-Pro-Ala mutation could not rescue the yeast delta ccc2 mutant, suggesting that the carboxyl terminal cysteine residue in the conserved Cys-Pro-Cys motif is essential for copper transport.	Proline	29-32	Mac1p	Saccharomyces cerevisiae S288C	14-19
9700506-7	1998	HLA-G binds nonamer peptides with leucine or isoleucine at position 2, proline at position 3 and leucine at position 9.	Proline	71-78	major histocompatibility complex, class I, G	Homo sapiens	0-5
9581865-5	1998	Not only murine but also human mutant p53 proteins carrying the mutational hot spot amino acid exchanges 175Arg--&gt;His, 273Arg--&gt;Pro, or 273Arg--&gt;His bound to the Xbal-IgE-MAR-DNA fragment.	Proline	134-137	tumor protein p53	Homo sapiens	38-41
9678763-1	1998	The P8.6 gene is encoded upstream of the mouse TCR Valpha1 gene in the anti-sense strand and its gene product contains the proline-rich region and tyrosine-isoleucine (Y-I) motif, which are consensus sequences for the SH2 and SH3 binding motifs respectively.	Proline	123-130	CD79B antigen like complex	Mus musculus	4-8
9626142-2	1998	Here, we describe seven children with GH, PRL, and TSH deficiency from three, reportedly unrelated, Middle Eastern families, harboring a newly recognized Pro- > Ser recessive mutation in codon 239 of the Pit-1 gene.	Proline	154-157	POU class 1 homeobox 1	Homo sapiens	204-209
9573241-1	1998	It has been previously shown that a proline substitution for any of the conserved leucine or isoleucine residues located in the leucine zipper-like heptad repeat sequence of human immunodeficiency virus type 1 (HIV-1) gp41 renders viruses noninfectious and envelope (Env) protein unable to mediate membrane fusion (S. S.-L. Chen, C.-N. Lee, W.-R. Lee, K. McIntosh, and T.-M. Lee, J. Virol.	Proline	36-43	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	267-270
9634101-3	1998	The amino acid sequence contains domains characteristic of baculovirus P10 proteins, e.g. a coiled-coil domain, a proline-rich motif and a positively charged C terminus.	Proline	114-121	P10	Buzura suppressaria nucleopolyhedrovirus	71-74
9592082-3	1998	Most phosphorylation occurs in the lys-ser-pro (KSP) repeats in the C-terminal tail domains of NF-H and NF-M.	Proline	43-46	neurofilament heavy chain	Rattus norvegicus	95-99
9592082-3	1998	Most phosphorylation occurs in the lys-ser-pro (KSP) repeats in the C-terminal tail domains of NF-H and NF-M.	Proline	43-46	neurofilament medium chain	Rattus norvegicus	104-108
9789805-4	1998	The T peptide allows the formation of tetrameric assemblies with a proline-rich attachment domain (PRAD) of collagen ColQ.	Proline	67-74	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	117-121
9614172-1	1998	Addition of ammonium ions to yeast cells growing on proline as the sole nitrogen source induces rapid inactivation and degradation of the general amino acid permease Gap1 through a process requiring the Npi1/Rsp5 ubiquitin (Ub) ligase.	Proline	52-59	amino acid permease GAP1	Saccharomyces cerevisiae S288C	166-170
9607197-12	1998	Furthermore, anti-TGF-beta antibody prevented the increase in proline incorporation induced by hypertonicity.	Proline	62-69	transforming growth factor, beta 1	Rattus norvegicus	18-26
9601051-6	1998	Finally, it is demonstrated that inhibition of Lp(a) assembly by proline, lysine, and lysine analogues, as well as by arginine and phenylalanine, is due to their ability to inhibit noncovalent association of apo(a) and apoB-100 and that these compounds directly exert their effects primarily through interactions with sequences contained within apo(a) kringle IV types 6-8.	Proline	65-72	lipoprotein(a)	Homo sapiens	47-52
9634586-0	1998	Pollen profilin function depends on interaction with proline-rich motifs.	Proline	53-60	profilin-4	Zea mays	7-15
9600920-9	1998	Furthermore, synthetic peptides spanning this newly identified proline-rich negative regulatory region (residues 80-93) are able to activate p53 sequence-specific DNA binding in vitro.	Proline	63-70	tumor protein p53	Homo sapiens	141-144
9645487-4	1998	Longer titin fragments, comprising a serine-proline-rich phosphorylation site and the next domain, do not interact.	Proline	44-51	titin	Homo sapiens	7-12
9582365-2	1998	This interaction was shown to involve the Src homology 3 (SH3) region of Csk and a proline-rich sequence of PEP termed P1 (SRRTDDEIPPPLPERTPESFIVVEE).	Proline	83-90	C-terminal Src kinase	Homo sapiens	73-76
9582365-2	1998	This interaction was shown to involve the Src homology 3 (SH3) region of Csk and a proline-rich sequence of PEP termed P1 (SRRTDDEIPPPLPERTPESFIVVEE).	Proline	83-90	progestagen associated endometrial protein	Homo sapiens	108-111
9582365-4	1998	Our studies revealed that the proline-rich core of the P1 region of PEP (PPPLPERT) was necessary but not sufficient for binding to p50(csk).	Proline	30-37	progestagen associated endometrial protein	Homo sapiens	68-71
9607760-2	1998	A common polymorphism that occurs in the p53 amino-acid sequence results in the presence of either a proline or an arginine at position 72.	Proline	101-108	tumor protein p53	Homo sapiens	41-44
9607760-3	1998	The effect of this polymorphism on the susceptibility of p53 to E6-mediated degradation has been investigated and the arginine form of p53 was found to be significantly more susceptible than the proline form.	Proline	195-202	tumor protein p53	Homo sapiens	57-60
9607760-3	1998	The effect of this polymorphism on the susceptibility of p53 to E6-mediated degradation has been investigated and the arginine form of p53 was found to be significantly more susceptible than the proline form.	Proline	195-202	tumor protein p53	Homo sapiens	135-138
9600096-3	1998	Comparison of the ULK1 and UNC-51 shows the highest conservation in the amino-terminal kinase domain, which is followed by a proline/serine-rich (PS) domain and a conserved carboxyl-terminal (C) domain.	Proline	125-132	Serine/threonine-protein kinase unc-51	Caenorhabditis elegans	27-33
9585562-4	1998	The utility of this technique is illustrated through the preparation of an array of proline-rich sequences based on the exchange factor C3G, one of the natural ligands of the N-terminal SH3 domain from the proto-oncogene, c-Crk.	Proline	84-91	Rap guanine nucleotide exchange factor 1	Homo sapiens	136-139
9585562-4	1998	The utility of this technique is illustrated through the preparation of an array of proline-rich sequences based on the exchange factor C3G, one of the natural ligands of the N-terminal SH3 domain from the proto-oncogene, c-Crk.	Proline	84-91	CRK proto-oncogene, adaptor protein	Homo sapiens	206-227
9589389-1	1998	Phosphorylation at certain proline-directed sites on the microtubule-associated protein 1B (MAP1B) is a characteristic feature of mitotic neuronal precursor cells and developing neurons and is particularly abundant within growing axons.	Proline	27-34	microtubule associated protein 1B	Homo sapiens	57-90
9589389-1	1998	Phosphorylation at certain proline-directed sites on the microtubule-associated protein 1B (MAP1B) is a characteristic feature of mitotic neuronal precursor cells and developing neurons and is particularly abundant within growing axons.	Proline	27-34	microtubule associated protein 1B	Homo sapiens	92-97
9582285-6	1998	The tif51A allele was rescued from these cells and shown to encode a serine to proline change within a predicted alpha-helical segment of the protein.	Proline	79-86	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	4-10
9619859-1	1998	Prolidase (EC 3.4.13.9) is an ubiquitously distributed imidodipeptidase that catalyzes the hydrolysis of dipeptides containing C-terminal proline or hydroxyproline.	Proline	138-145	peptidase D	Homo sapiens	0-9
9580701-0	1998	Adjacent proline residues in the inhibitory domain of the Oct-2 transcription factor play distinct functional roles.	Proline	9-16	POU class 2 homeobox 2	Homo sapiens	58-63
9644912-3	1998	We propose inhibition of thromboplastin and thrombin formation in the serum by the studied proline-containing peptides both in vitro and in vivo.	Proline	91-98	coagulation factor II	Rattus norvegicus	44-52
9623769-4	1998	Thus, replacement of the negatively charged E250 with an uncharged, polar serine residue substantially hampered assembly of CYP2B4 (delta2-27); introduction of an alpha-helix-disrupting proline completely blocked the formation of holoenzyme.	Proline	186-193	cytochrome P450 2B4	Oryctolagus cuniculus	124-130
9614933-4	1998	A coding sequence polymorphism of CR1 predicted to cause a Pro--&gt;Arg substitution in its proximal extramembranous region was tightly linked in Caucasians to the site of the HindIII RFLP.	Proline	59-62	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	34-37
9881747-4	1998	The high (approximately 25%) proline content of MUC7 including 19 diproline segments suggested the presence of polyproline type structures.	Proline	29-36	mucin 7, secreted	Homo sapiens	48-52
9619373-9	1998	The authors show in addition, that TFG-beta blocks the IL-1 induced inhibitory effect on glycosaminoglycan (GAG) and collagen production, evaluated with [3H]glucosamine and [3H]proline incorporation studies, respectively.	Proline	177-184	interleukin 1 complex	Mus musculus	55-59
9525481-1	1998	It is well known that v-Src phosphorylates various substrates on tyrosine residue and associates with tyrosine-phosphorylated proteins as well as proline-rich ligands through its SH2 and SH3 domains, respectively, thereby inducing oncogenic transformation.	Proline	146-153	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	24-27
9570752-2	1998	In addition, dynamin-related GTPases, such as the yeast Golgi protein Vps1p, which lack both the pleckstrin homology motif and the proline-rich region, participate in vesicular transport within the secretory pathway in lower eukaryotes.	Proline	131-138	dynamin-like GTPase VPS1	Saccharomyces cerevisiae S288C	70-75
9589637-10	1998	We found the second nucleotide of normal codon 66 (CTT), a thymine, was substituted by a cytosine (CCT), resulting in the replacement of the normal leucine by proline.	Proline	159-166	CCT	Homo sapiens	99-102
9557657-2	1998	The extracellular domain of havcr-1 has an N-terminal Cys-rich region that displays homology with sequences of members of the immunoglobulin superfamily, followed by a Thr/Ser/Pro (TSP)-rich region characteristic of mucin-like O-glycosylated proteins.	Proline	176-179	hepatitis A virus cellular receptor 1	Homo sapiens	28-35
9620104-2	1998	Inversion of the proline-lysine amino acid sequence at positions 28 and 29 on the B chain is responsible for its more rapid absorption, faster onset, and shorter duration of action compared with regular insulin.	Proline	17-24	insulin	Homo sapiens	203-210
9547266-0	1998	The activation function 2 domain of hepatic nuclear factor 4 is regulated by a short C-terminal proline-rich repressor domain.	Proline	96-103	hepatic nuclear factor 4, alpha	Mus musculus	36-60
9557699-0	1998	A proline-rich motif (PPPY) in the Gag polyprotein of Mason-Pfizer monkey virus plays a maturation-independent role in virion release.	Proline	2-9	Pr78	Mason-Pfizer monkey virus	35-38
9557699-7	1998	The pp16 protein is a C-terminally located cleavage product of pp24 and contains a proline-rich motif (PPPY) that is conserved among the Gag proteins of a wide variety of retroviruses.	Proline	83-90	Pr78	Mason-Pfizer monkey virus	137-140
9571048-5	1998	We have assessed the structural impact of binding to a ligand through addition of a peptide corresponding to a proline-rich region of a Hck target, the GTPase activating protein of the Ras pathway.	Proline	111-118	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	136-139
9553131-5	1998	Half of the carboxyl-terminal region of the GH receptor is dispensable for FAK activation, but FAK activation does require the proline-rich box 1 region of the GH receptor, indicative that FAK is downstream of JAK2.	Proline	127-134	protein tyrosine kinase 2	Homo sapiens	95-98
9553131-5	1998	Half of the carboxyl-terminal region of the GH receptor is dispensable for FAK activation, but FAK activation does require the proline-rich box 1 region of the GH receptor, indicative that FAK is downstream of JAK2.	Proline	127-134	growth hormone receptor	Homo sapiens	160-171
9531650-4	1998	RESULTS: In all 43 samples, the K-ras codon 11 was CCT (proline), and the opposite strand sequenced was AGG.	Proline	56-63	KRAS proto-oncogene, GTPase	Homo sapiens	32-37
9553131-5	1998	Half of the carboxyl-terminal region of the GH receptor is dispensable for FAK activation, but FAK activation does require the proline-rich box 1 region of the GH receptor, indicative that FAK is downstream of JAK2.	Proline	127-134	protein tyrosine kinase 2	Homo sapiens	95-98
9545257-3	1998	The monocyte CADTK was 5 kDa smaller than protein from epithelial cells; isolation and sequencing of the monocyte CADTK cDNA revealed a predicted 42-amino acid deletion between the two proline-rich domains of the enzyme.	Proline	185-192	protein tyrosine kinase 2 beta	Homo sapiens	13-18
9545257-3	1998	The monocyte CADTK was 5 kDa smaller than protein from epithelial cells; isolation and sequencing of the monocyte CADTK cDNA revealed a predicted 42-amino acid deletion between the two proline-rich domains of the enzyme.	Proline	185-192	protein tyrosine kinase 2 beta	Homo sapiens	114-119
9591785-5	1998	EF1alpha bound to the 186 amino acids region of Bni1p, located between the FH1 domain, the proline-rich profilin-binding domain, and the FH2 domain, of which function is not known.	Proline	91-98	formin BNI1	Saccharomyces cerevisiae S288C	48-53
9598309-10	1998	CDC5L was also predicted to contain a hydrophilic, proline-rich region in its central part, which might function as a transcriptional activating domain.	Proline	51-58	cell division cycle 5 like	Homo sapiens	0-5
9598321-5	1998	The TRIP6 protein displays a proline-rich N-terminal region linked to three tandemly arrayed C-terminal LIM domains.	Proline	29-36	thyroid hormone receptor interactor 6	Homo sapiens	4-9
9545296-8	1998	This demonstrates that PDI has multiple functions in the folding of the same protein, that is, as a catalyst for disulfide bond formation, as a subunit of P4-H during proline hydroxylation, and independently as a molecular chaperone during chain assembly.	Proline	167-174	prolyl 4-hydroxylase subunit beta	Homo sapiens	23-26
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Proline	10-13	parathyroid hormone	Homo sapiens	14-17
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Proline	10-13	parathyroid hormone	Homo sapiens	189-192
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Proline	10-13	parathyroid hormone like hormone	Homo sapiens	214-219
9531650-6	1998	CONCLUSION: The 11th codon of the human K-ras oncogene in Chinese is CCT (Proline).	Proline	74-81	KRAS proto-oncogene, GTPase	Homo sapiens	40-45
9531650-6	1998	CONCLUSION: The 11th codon of the human K-ras oncogene in Chinese is CCT (Proline).	Proline	74-81	CCT	Homo sapiens	69-72
9546354-4	1998	The leucine substitution by proline was shown to affect a residue, which was precisely conserved in different human, rodent, and drosophila integrin-beta polypeptides, and consequently disrupts the alpha-helix formation of the polypeptide segment as determined by Garnier alpha-helicity plot.	Proline	28-35	myospheroid	Drosophila melanogaster	140-153
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Proline	18-21	parathyroid hormone	Homo sapiens	14-17
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Proline	18-21	parathyroid hormone	Homo sapiens	189-192
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Proline	18-21	parathyroid hormone like hormone	Homo sapiens	214-219
9787767-7	1998	Turtle WT1, like those of the alligator, chicken, and Xenopus lacks the proline- and glycine-rich stretches that are present in mammalian WT1.	Proline	72-79	Wilms tumor 1	Gallus gallus	7-10
9648522-0	1998	Synthesis and antibacterial activities of new carbapenems having a proline reverse amide moiety at the C-2 position.	Proline	67-74	complement C2	Homo sapiens	103-106
9648522-1	1998	The synthesis of new 1 beta-methylcarbapenems (1a-l) having a proline reverse amide moiety at the C-2 position and their in vitro antibacterial activities are described.	Proline	62-69	complement C2	Homo sapiens	98-101
9516124-10	1998	Detailed study of the C-terminal truncated cytoplasmic domain of hIL-5Ralpha revealed that the cytoplasmic stretch at position 346-387, containing the proline-rich region, is necessary for JAK2 binding.	Proline	151-158	interleukin 5 receptor subunit alpha	Homo sapiens	65-76
9516124-10	1998	Detailed study of the C-terminal truncated cytoplasmic domain of hIL-5Ralpha revealed that the cytoplasmic stretch at position 346-387, containing the proline-rich region, is necessary for JAK2 binding.	Proline	151-158	Janus kinase 2	Homo sapiens	189-193
9787767-7	1998	Turtle WT1, like those of the alligator, chicken, and Xenopus lacks the proline- and glycine-rich stretches that are present in mammalian WT1.	Proline	72-79	WT1 transcription factor	Homo sapiens	138-141
9578462-6	1998	The NH2-terminal sequence of the 47,000- and 24,000-Mr species is Phe82-Ser-Ser-Phe-Pro-Gly, which is identical to that of stromelysin 2.	Proline	84-87	matrix metallopeptidase 10	Homo sapiens	123-136
9528972-3	1998	Deletion of the proline-rich box 1 of GHR (GHR(deltaP)) abrogated all of these responses to GH, indicating that box 1, a site of association of GHR with the tyrosine kinase JAK2, is crucial for these GH-stimulated responses.	Proline	16-23	growth hormone receptor	Cricetulus griseus	38-41
9528972-3	1998	Deletion of the proline-rich box 1 of GHR (GHR(deltaP)) abrogated all of these responses to GH, indicating that box 1, a site of association of GHR with the tyrosine kinase JAK2, is crucial for these GH-stimulated responses.	Proline	16-23	growth hormone receptor	Cricetulus griseus	43-54
9528972-3	1998	Deletion of the proline-rich box 1 of GHR (GHR(deltaP)) abrogated all of these responses to GH, indicating that box 1, a site of association of GHR with the tyrosine kinase JAK2, is crucial for these GH-stimulated responses.	Proline	16-23	growth hormone receptor	Cricetulus griseus	43-46
9528972-3	1998	Deletion of the proline-rich box 1 of GHR (GHR(deltaP)) abrogated all of these responses to GH, indicating that box 1, a site of association of GHR with the tyrosine kinase JAK2, is crucial for these GH-stimulated responses.	Proline	16-23	tyrosine-protein kinase JAK2	Cricetulus griseus	173-177
9675877-2	1998	Identified as the protein product of the c-cbl proto-oncogene, the cellular homolog to the transforming gene of a murine retrovirus, Cbl comprises an N-terminal transforming region (Cbl-N), which contains a phosphotyrosine binding (PTB) domain, and a C-terminal modular region (Cbl-C) containing a RING finger motif, a large proline-rich region and a leucine zipper.	Proline	325-332	Casitas B-lineage lymphoma	Mus musculus	41-46
9560400-0	1998	A proline-rich region in the Zeste protein essential for transvection and white repression by Zeste.	Proline	2-9	zeste	Drosophila melanogaster	29-34
9560400-0	1998	A proline-rich region in the Zeste protein essential for transvection and white repression by Zeste.	Proline	2-9	zeste	Drosophila melanogaster	94-99
9499384-8	1998	We have also determined that the introduction of a proline residue at the +3 position flanking the potential glycosylation site eliminated ppGaNTase-T3 selectivity toward rHIV observed both in vivo and in vitro .	Proline	51-58	polypeptide N-acetylgalactosaminyltransferase 3	Mus musculus	139-151
9675877-2	1998	Identified as the protein product of the c-cbl proto-oncogene, the cellular homolog to the transforming gene of a murine retrovirus, Cbl comprises an N-terminal transforming region (Cbl-N), which contains a phosphotyrosine binding (PTB) domain, and a C-terminal modular region (Cbl-C) containing a RING finger motif, a large proline-rich region and a leucine zipper.	Proline	325-332	Casitas B-lineage lymphoma	Mus musculus	133-136
9675877-2	1998	Identified as the protein product of the c-cbl proto-oncogene, the cellular homolog to the transforming gene of a murine retrovirus, Cbl comprises an N-terminal transforming region (Cbl-N), which contains a phosphotyrosine binding (PTB) domain, and a C-terminal modular region (Cbl-C) containing a RING finger motif, a large proline-rich region and a leucine zipper.	Proline	325-332	Casitas B-lineage lymphoma	Mus musculus	182-185
9538891-5	1998	CONCLUSIONS: The mutation indicates that the proline-serine-threonine-rich domain at the C terminus of the PAX6 protein plays a role in ocular anterior segment morphogenesis.	Proline	45-52	paired box 6	Homo sapiens	107-111
9615469-0	1998	Acute inductive effects on oncogenic proline-directed protein kinase FA/GSK-3 alpha in NIH 3T3 cells by ethanol and cadmium.	Proline	37-44	glycogen synthase kinase 3 alpha	Mus musculus	72-83
9568986-2	1998	Replacement of proline by alanine (ATK) in the PTK motif abolished transmission almost completely both from plants and from membranes.	Proline	15-22	protein tyrosine kinase 2 beta	Homo sapiens	47-50
9569179-2	1998	A six nucleotide insert, AATCCC, was found in exon 11 of the vWF gene, predicting the insertion of the amino acids asparagine and proline between phenylalanine 404 and threonine 405 of the vWF propeptide.	Proline	130-137	von Willebrand factor	Homo sapiens	61-64
9569179-2	1998	A six nucleotide insert, AATCCC, was found in exon 11 of the vWF gene, predicting the insertion of the amino acids asparagine and proline between phenylalanine 404 and threonine 405 of the vWF propeptide.	Proline	130-137	von Willebrand factor	Homo sapiens	189-192
9516413-2	1998	The C-terminal region of PAX6 is proline/serine/threonine-rich (PST) and functions as a potent transactivation domain when attached to a heterologous DNA-binding domain of the yeast transcription factor, GAL4.	Proline	33-40	paired box 6	Homo sapiens	25-29
9507006-5	1998	The product of the sirm gene is a serine/threonine-rich protein with several proline-rich motifs and an NPNY motif, conforming to the consensus sequence recognized by the phosphotyrosine binding domains of insulin receptor substrate and Shc proteins.	Proline	77-84	insulin receptor	Mus musculus	206-222
9516488-9	1998	However, although the proline-rich motif of hnRNP C is involved in the interaction with Grb2, it is not in the binding to Grb3-3.	Proline	22-29	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	44-51
9516488-9	1998	However, although the proline-rich motif of hnRNP C is involved in the interaction with Grb2, it is not in the binding to Grb3-3.	Proline	22-29	growth factor receptor bound protein 2	Homo sapiens	88-92
9569023-3	1998	Dab2 contains a C-terminal proline-rich domain with sequences similar to those found in Sos, a guanine nucleotide exchange factor for Ras.	Proline	27-34	DAB adaptor protein 2	Homo sapiens	0-4
9569023-3	1998	Dab2 contains a C-terminal proline-rich domain with sequences similar to those found in Sos, a guanine nucleotide exchange factor for Ras.	Proline	27-34	xylosyltransferase 2	Homo sapiens	88-91
9569023-4	1998	The proline-rich sequences of Sos mediate the interaction of Sos with Grb2, an adaptor protein which coupled tyrosine kinase receptors to Sos.	Proline	4-11	xylosyltransferase 2	Homo sapiens	30-33
9569023-4	1998	The proline-rich sequences of Sos mediate the interaction of Sos with Grb2, an adaptor protein which coupled tyrosine kinase receptors to Sos.	Proline	4-11	xylosyltransferase 2	Homo sapiens	61-64
9569023-4	1998	The proline-rich sequences of Sos mediate the interaction of Sos with Grb2, an adaptor protein which coupled tyrosine kinase receptors to Sos.	Proline	4-11	growth factor receptor bound protein 2	Homo sapiens	70-74
9569023-4	1998	The proline-rich sequences of Sos mediate the interaction of Sos with Grb2, an adaptor protein which coupled tyrosine kinase receptors to Sos.	Proline	4-11	xylosyltransferase 2	Homo sapiens	61-64
9569023-8	1998	Proline-rich peptides corresponding to Dab2 (#661-669) and to Sos (#1146-1161) inhibited the binding of Dab2 to Grb2, but were less effective in disrupting the Grb2-Sos complex.	Proline	0-7	DAB adaptor protein 2	Homo sapiens	39-43
9569023-8	1998	Proline-rich peptides corresponding to Dab2 (#661-669) and to Sos (#1146-1161) inhibited the binding of Dab2 to Grb2, but were less effective in disrupting the Grb2-Sos complex.	Proline	0-7	xylosyltransferase 2	Homo sapiens	62-65
9569023-8	1998	Proline-rich peptides corresponding to Dab2 (#661-669) and to Sos (#1146-1161) inhibited the binding of Dab2 to Grb2, but were less effective in disrupting the Grb2-Sos complex.	Proline	0-7	DAB adaptor protein 2	Homo sapiens	104-108
9569023-8	1998	Proline-rich peptides corresponding to Dab2 (#661-669) and to Sos (#1146-1161) inhibited the binding of Dab2 to Grb2, but were less effective in disrupting the Grb2-Sos complex.	Proline	0-7	growth factor receptor bound protein 2	Homo sapiens	112-116
9569023-8	1998	Proline-rich peptides corresponding to Dab2 (#661-669) and to Sos (#1146-1161) inhibited the binding of Dab2 to Grb2, but were less effective in disrupting the Grb2-Sos complex.	Proline	0-7	growth factor receptor bound protein 2	Homo sapiens	160-164
9569023-8	1998	Proline-rich peptides corresponding to Dab2 (#661-669) and to Sos (#1146-1161) inhibited the binding of Dab2 to Grb2, but were less effective in disrupting the Grb2-Sos complex.	Proline	0-7	xylosyltransferase 2	Homo sapiens	165-168
9569023-9	1998	The expressed proline-rich domain of Dab2 (#600-730) bound Grb2, but other regions of Dab2 failed to bind Grb2.	Proline	14-21	DAB adaptor protein 2	Homo sapiens	37-41
9569023-9	1998	The expressed proline-rich domain of Dab2 (#600-730) bound Grb2, but other regions of Dab2 failed to bind Grb2.	Proline	14-21	growth factor receptor bound protein 2	Homo sapiens	59-63
9569023-11	1998	These data indicate that Dab2 binds to the SH3 domains of Grb2 via its C-terminal proline-rich sequences.	Proline	82-89	DAB adaptor protein 2	Homo sapiens	25-29
9569023-11	1998	These data indicate that Dab2 binds to the SH3 domains of Grb2 via its C-terminal proline-rich sequences.	Proline	82-89	growth factor receptor bound protein 2	Homo sapiens	58-62
9525577-1	1998	The proline-rich SH3-binding (SH3B) motif of the tyrosine kinase-interacting protein (Tip) of herpesvirus saimiri (HVS) is required for binding to the cellular Src family kinase Lck.	Proline	4-11	TOR signaling pathway regulator	Homo sapiens	86-89
9525577-1	1998	The proline-rich SH3-binding (SH3B) motif of the tyrosine kinase-interacting protein (Tip) of herpesvirus saimiri (HVS) is required for binding to the cellular Src family kinase Lck.	Proline	4-11	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	178-181
9525577-2	1998	We constructed a mutant form of HVS in which prolines in the SH3B motif of Tip were altered to alanines.	Proline	45-53	TOR signaling pathway regulator	Homo sapiens	75-78
9546659-2	1998	The proline-containing V3 loop of gp120 determines the selection of the chemokine receptor and participates in conformational changes on binding of gp120 to CD4.	Proline	4-11	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	34-39
9494093-0	1998	Interaction of two proline-rich sequences of cell adhesion kinase beta with SH3 domains of p130Cas-related proteins and a GTPase-activating protein, Graf.	Proline	19-26	protein tyrosine kinase 2 beta	Rattus norvegicus	45-70
9494093-0	1998	Interaction of two proline-rich sequences of cell adhesion kinase beta with SH3 domains of p130Cas-related proteins and a GTPase-activating protein, Graf.	Proline	19-26	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	91-98
9494093-2	1998	CAKbeta contains two proline-rich sequences within its C-terminal region.	Proline	21-28	protein tyrosine kinase 2 beta	Rattus norvegicus	0-7
9494093-3	1998	Since proline-rich sequences present in the corresponding region of FAK are known to mediate protein-protein interactions by binding to SH3 domains, we investigated binding of CAKbeta to a panel of SH3 domains.	Proline	6-13	protein tyrosine kinase 2	Rattus norvegicus	68-71
9494093-3	1998	Since proline-rich sequences present in the corresponding region of FAK are known to mediate protein-protein interactions by binding to SH3 domains, we investigated binding of CAKbeta to a panel of SH3 domains.	Proline	6-13	protein tyrosine kinase 2 beta	Rattus norvegicus	176-183
9494093-5	1998	Mutational analysis indicated that the proline-rich sequences of CAKbeta mediate this interaction.	Proline	39-46	protein tyrosine kinase 2 beta	Rattus norvegicus	65-72
9494093-6	1998	Each of the two proline-rich sequences fused to GST bound directly to these SH3 domains in dot blot analysis.	Proline	16-23	hematopoietic prostaglandin D synthase	Rattus norvegicus	48-51
9494093-7	1998	A competitive binding assay revealed that the first proline-rich sequence of CAKbeta preferentially associated with the SH3 domain of Cas.	Proline	52-59	protein tyrosine kinase 2 beta	Rattus norvegicus	77-84
9494093-7	1998	A competitive binding assay revealed that the first proline-rich sequence of CAKbeta preferentially associated with the SH3 domain of Cas.	Proline	52-59	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	134-137
9524259-5	1998	The putative hp55 gamma protein is composed of a unique amino terminal region followed by a proline-rich motif and two Src homology 2 (SH2) domains, which are highly homologous to those in mouse p55PIK, rat p55 gamma, human p85 alpha and bovine p85 beta; it contains no SH3 domain.	Proline	92-99	DNA polymerase gamma 2, accessory subunit	Homo sapiens	13-17
9524259-5	1998	The putative hp55 gamma protein is composed of a unique amino terminal region followed by a proline-rich motif and two Src homology 2 (SH2) domains, which are highly homologous to those in mouse p55PIK, rat p55 gamma, human p85 alpha and bovine p85 beta; it contains no SH3 domain.	Proline	92-99	phosphoinositide-3-kinase regulatory subunit 3	Homo sapiens	14-23
9546659-2	1998	The proline-containing V3 loop of gp120 determines the selection of the chemokine receptor and participates in conformational changes on binding of gp120 to CD4.	Proline	4-11	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	148-153
9546659-2	1998	The proline-containing V3 loop of gp120 determines the selection of the chemokine receptor and participates in conformational changes on binding of gp120 to CD4.	Proline	4-11	CD4 molecule	Homo sapiens	157-160
9521669-11	1998	Finally, deletion mutagenesis of calnexin and calreticulin identified a central proline-rich region characterized by two tandem repeat motifs as a segment capable of binding oligosaccharide.	Proline	80-87	calnexin	Homo sapiens	33-41
9488672-11	1998	This provides a mechanism to regulate the function of HPRG (the local pH) and rationalizes the role of its unique, conserved histidine-proline-rich domain.	Proline	135-142	histidine rich glycoprotein	Homo sapiens	54-58
9494093-8	1998	The second proline-rich sequence of CAKbeta bound to the SH3 domain of Graf with higher specificity than the corresponding proline-rich sequence of FAK.	Proline	11-18	protein tyrosine kinase 2 beta	Rattus norvegicus	36-43
9494093-8	1998	The second proline-rich sequence of CAKbeta bound to the SH3 domain of Graf with higher specificity than the corresponding proline-rich sequence of FAK.	Proline	11-18	protein tyrosine kinase 2	Rattus norvegicus	148-151
9494093-8	1998	The second proline-rich sequence of CAKbeta bound to the SH3 domain of Graf with higher specificity than the corresponding proline-rich sequence of FAK.	Proline	123-130	protein tyrosine kinase 2 beta	Rattus norvegicus	36-43
9494093-8	1998	The second proline-rich sequence of CAKbeta bound to the SH3 domain of Graf with higher specificity than the corresponding proline-rich sequence of FAK.	Proline	123-130	protein tyrosine kinase 2	Rattus norvegicus	148-151
9551089-11	1998	To get further insight into the mechanism of the paradoxical activation of receptor signalling by the R86P mutation, the codons for proline, alanine, and glycine were substituted in the R86 position of the insulin receptor cDNA by PCR-mediated mutagenesis and stably transfected into Chinese hamster ovary (CHO) cells.	Proline	132-139	insulin receptor	Cricetulus griseus	206-222
9521656-2	1998	Here we report the processing of a number of ubiquitin derivatives by two human UCH isozymes (isozymes L1 and L3) and find that these enzymes show little discrimination based on the P1" amino acid, except that proline is cleaved slowly.	Proline	210-217	L1 cell adhesion molecule	Homo sapiens	103-112
9573369-2	1998	The 86-proline residue belongs to the highly conserved pentapeptide C-X-P-S-R in which cysteine modification to a formylglycine is required for sulfatase activity.	Proline	7-14	arylsulfatase family member H	Homo sapiens	144-153
9521669-11	1998	Finally, deletion mutagenesis of calnexin and calreticulin identified a central proline-rich region characterized by two tandem repeat motifs as a segment capable of binding oligosaccharide.	Proline	80-87	calreticulin	Homo sapiens	46-58
9546050-1	1998	The Ile-Pro sequence of CA074, potent covalent-type inhibitor, is necessary to exhibit the specificity for cathepsin B, but not for papain.	Proline	8-11	cathepsin B	Homo sapiens	107-118
9498488-5	1998	METHODS: Mammalian cell cultures were treated with azetidine, a proline analog, which elicits a stress response that includes the induction of the expression of glucose-regulated protein GRP78 and heat shock protein HSP70.	Proline	64-71	heat shock protein family A (Hsp70) member 5	Homo sapiens	187-192
9498488-5	1998	METHODS: Mammalian cell cultures were treated with azetidine, a proline analog, which elicits a stress response that includes the induction of the expression of glucose-regulated protein GRP78 and heat shock protein HSP70.	Proline	64-71	heat shock protein family A (Hsp70) member 4	Homo sapiens	216-221
9593584-8	1998	The beta1-adrenergic receptor antagonist atenolol blocked both tissue-specific expression of proline-rich proteins and induction of p34cdc2.	Proline	93-100	adrenergic receptor, beta 1	Mus musculus	4-29
9510974-7	1998	The molecular weight of GAPD-S is higher than the predicted molecular weight of 47,445, apparently due to a proline-rich 105-amino acid domain at the N-terminus.	Proline	108-115	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Mus musculus	24-30
9510974-8	1998	Recombinant GAPD-S protein lacking the proline-rich region migrated at M(r) 38,250, comparably to somatic GAPD, which also lacks the proline-rich domain.	Proline	39-46	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Mus musculus	12-18
9510974-8	1998	Recombinant GAPD-S protein lacking the proline-rich region migrated at M(r) 38,250, comparably to somatic GAPD, which also lacks the proline-rich domain.	Proline	39-46	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	12-16
9510974-8	1998	Recombinant GAPD-S protein lacking the proline-rich region migrated at M(r) 38,250, comparably to somatic GAPD, which also lacks the proline-rich domain.	Proline	133-140	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Mus musculus	12-18
9510974-8	1998	Recombinant GAPD-S protein lacking the proline-rich region migrated at M(r) 38,250, comparably to somatic GAPD, which also lacks the proline-rich domain.	Proline	133-140	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	12-16
9502416-8	1998	Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum.	Proline	79-82	transforming growth factor beta induced	Homo sapiens	223-233
9502416-8	1998	Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum.	Proline	79-82	guanylate cyclase 2E, pseudogene	Homo sapiens	283-286
9502416-8	1998	Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum.	Proline	79-82	transforming growth factor beta induced	Homo sapiens	306-316
9568289-1	1998	A novel hexapeptide, H-Pro-Ser-Nva-Gly-Asp-Trp-OH 6, a specific antagonist of platelet fibrinogen receptor (GpIIb/IIIa), was discovered in a structure-activity relationship (SAR) study where the role of the N-terminal Pro moiety of an RGD-containing peptide, H-Pro-Ser-Arg-Gly-Asp-Trp-OH 1, which is a potent but not specific antagonist toward GpIIb/IIIa integrin, was investigated.	Proline	23-26	integrin subunit alpha 2b	Homo sapiens	108-113
9568289-1	1998	A novel hexapeptide, H-Pro-Ser-Nva-Gly-Asp-Trp-OH 6, a specific antagonist of platelet fibrinogen receptor (GpIIb/IIIa), was discovered in a structure-activity relationship (SAR) study where the role of the N-terminal Pro moiety of an RGD-containing peptide, H-Pro-Ser-Arg-Gly-Asp-Trp-OH 1, which is a potent but not specific antagonist toward GpIIb/IIIa integrin, was investigated.	Proline	23-26	integrin subunit alpha 2b	Homo sapiens	344-349
9568289-5	1998	Further structure-activity relationship studies at each position of the peptide sequence suggest a novel motif sequence, Pro-X1-X2-X3-Asp-X4, for specific GpIIb/IIIa integrin recognition, in which the N-terminal free Pro residue and the Asp residue at the fifth position are essential to the activity.	Proline	121-124	integrin subunit alpha 2b	Homo sapiens	155-160
9720754-7	1998	The cytoplasmic proline-rich regions of both IL-5Ralpha and (beta)c are essential for the IL-5 signalling.	Proline	16-23	interleukin 5 receptor, alpha	Mus musculus	45-55
9508791-4	1998	The dip5 mutation caused a several hundred-fold reduction of uptake of the two amino acids, both in cells grown on proline as a nitrogen source and in cells grown on ammonium.	Proline	115-122	Dip5p	Saccharomyces cerevisiae S288C	4-8
9508791-5	1998	DIP5-dependent uptake of L-aspartate and L-glutamate was somewhat lower in ammonium-grown cells than in proline-grown cells.	Proline	104-111	Dip5p	Saccharomyces cerevisiae S288C	0-4
9720754-7	1998	The cytoplasmic proline-rich regions of both IL-5Ralpha and (beta)c are essential for the IL-5 signalling.	Proline	16-23	interleukin 5	Mus musculus	45-49
9576622-7	1998	In addition, we evaluated the impact of the proline residues in the HCDR3 of IE12 on its activity, because they are known to restrict backbone flexibility.	Proline	44-51	olfactory receptor family 13 subfamily A member 20	Mus musculus	77-81
9579804-5	1998	The proline residues and the induced-conformations are of great importance for the recognition of MUC5AC peptides but they are not the only factors for the choice of the O-glycosylation sites.	Proline	4-11	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	98-104
9472095-1	1998	The polymorphism of p53 gene at codon 72 consisting of either arginine (Arg)- or proline (Pro)-encoded allele is suggested to be associated with the susceptibility of tobacco-related lung cancer.	Proline	81-88	tumor protein p53	Homo sapiens	20-23
9472095-1	1998	The polymorphism of p53 gene at codon 72 consisting of either arginine (Arg)- or proline (Pro)-encoded allele is suggested to be associated with the susceptibility of tobacco-related lung cancer.	Proline	90-93	tumor protein p53	Homo sapiens	20-23
9499405-9	1998	In a separate paper, we have shown that Pin1 is a phosphorylation-dependent PPIase that can recognize specifically the phosphorylated Ser/Thr-Pro bonds present in mitotic phosphoproteins.	Proline	142-145	peptidylprolyl cis/trans isomerase, NIMA-interacting 1 L homeolog	Xenopus laevis	40-44
9499405-9	1998	In a separate paper, we have shown that Pin1 is a phosphorylation-dependent PPIase that can recognize specifically the phosphorylated Ser/Thr-Pro bonds present in mitotic phosphoproteins.	Proline	142-145	FKBP prolyl isomerase 1A L homeolog	Xenopus laevis	76-82
9478994-3	1998	Moreover, the peptide GPPPQVPSRPNR from dynamin also blocks the binding of dynamin to the proline-rich recognition platform of Grb2.	Proline	90-97	dynamin-2	Cricetulus griseus	40-47
9498793-0	1998	Mutation of proline 211 reduces shedding of the human p75 TNF receptor.	Proline	12-19	TNF receptor superfamily member 1B	Homo sapiens	54-57
9498793-7	1998	This work shows that a single amino acid mutation at proline 211 of human p75 TNF-R can prevent shedding from the cell surface, and that deletion of other previously proposed putative cleavage sites of the human p75 TNF-R does not prevent its shedding.	Proline	53-60	TNF receptor superfamily member 1B	Homo sapiens	74-77
9498793-7	1998	This work shows that a single amino acid mutation at proline 211 of human p75 TNF-R can prevent shedding from the cell surface, and that deletion of other previously proposed putative cleavage sites of the human p75 TNF-R does not prevent its shedding.	Proline	53-60	TNF receptor superfamily member 1A	Homo sapiens	78-83
9498793-7	1998	This work shows that a single amino acid mutation at proline 211 of human p75 TNF-R can prevent shedding from the cell surface, and that deletion of other previously proposed putative cleavage sites of the human p75 TNF-R does not prevent its shedding.	Proline	53-60	TNF receptor superfamily member 1B	Homo sapiens	212-215
9499091-2	1998	We have constructed 11 mutants of Sindbis virus bearing Phe, Ala, Thr, Cys, Leu, Met, Asn, Gln, Glu, Arg, or Pro at the N terminus of nsP4.	Proline	109-112	serine protease 57	Homo sapiens	134-138
9487127-1	1998	We have used coexpression of a salivary basic proline-rich protein (PRP) along with a proline-rich proteoglycan (PRPg) in pituitary AtT-20 cells to examine the regulation of glycosaminoglycan (GAG) biosynthesis and the storage of these secretory products for regulated secretion.	Proline	46-53	proline rich protein HaeIII subfamily 1	Mus musculus	68-71
9798267-4	1998	Prolidase [E.C.3.4.13.9] cleaves imidodipeptides containing C-terminal proline, providing large amount of proline for collagen resynthesis.	Proline	71-78	peptidase D	Homo sapiens	0-9
9798267-4	1998	Prolidase [E.C.3.4.13.9] cleaves imidodipeptides containing C-terminal proline, providing large amount of proline for collagen resynthesis.	Proline	106-113	peptidase D	Homo sapiens	0-9
9541112-3	1998	The mutation consisted of a previously unreported T to C transition in exon 13 of the PPO gene, resulting in the substitution of a polar serine by a non-polar proline (S450P).	Proline	159-166	protoporphyrinogen oxidase	Homo sapiens	86-89
9630436-3	1998	IA-4 cDNA is 1,007 bp in length and predicts a protein of 187 amino acids with a molecular mass of 19,940 D. Examination of the amino acid sequence showed a high content of arginine (18.7%), proline (14.4%), alanine (16.0%), leucine (13.4%) and glycine (9.6%).	Proline	191-198	proprotein convertase subtilisin/kexin type 1 inhibitor	Mus musculus	0-4
9478994-3	1998	Moreover, the peptide GPPPQVPSRPNR from dynamin also blocks the binding of dynamin to the proline-rich recognition platform of Grb2.	Proline	90-97	dynamin-2	Cricetulus griseus	75-82
9478994-3	1998	Moreover, the peptide GPPPQVPSRPNR from dynamin also blocks the binding of dynamin to the proline-rich recognition platform of Grb2.	Proline	90-97	growth factor receptor-bound protein 2	Cricetulus griseus	127-131
9472028-9	1998	Interestingly, SRPK2 also contains a proline-rich sequence at its NH2 terminus, and a recent study showed that this NH2-terminal sequence has the capacity to interact with a WW domain protein in vitro.	Proline	37-44	SRSF protein kinase 2	Homo sapiens	15-20
9478994-6	1998	It was also observed that the proline-rich peptide from dynamin was unable to dissociate the Grb2.Sos complex, whereas the proline-rich peptide from Son of sevenless (Sos) inhibited Grb2.	Proline	30-37	dynamin-2	Cricetulus griseus	56-63
9485396-0	1998	Structure, function, and temperature sensitivity of directed, random mutants at proline 76 and glycine 77 in omega-loop D of yeast iso-1-cytochrome c. Residues 75-78 form a tight turn within Omega-loop D in Saccharomyces cerevisiae iso-1-cytochrome c. Directed, random mutagenesis of invariant residues proline 76 and glycine 77 in this turn were analyzed for the in vivo functionality and level of protein within the cell.	Proline	80-87	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	131-136
9485396-0	1998	Structure, function, and temperature sensitivity of directed, random mutants at proline 76 and glycine 77 in omega-loop D of yeast iso-1-cytochrome c. Residues 75-78 form a tight turn within Omega-loop D in Saccharomyces cerevisiae iso-1-cytochrome c. Directed, random mutagenesis of invariant residues proline 76 and glycine 77 in this turn were analyzed for the in vivo functionality and level of protein within the cell.	Proline	80-87	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	232-237
9485396-0	1998	Structure, function, and temperature sensitivity of directed, random mutants at proline 76 and glycine 77 in omega-loop D of yeast iso-1-cytochrome c. Residues 75-78 form a tight turn within Omega-loop D in Saccharomyces cerevisiae iso-1-cytochrome c. Directed, random mutagenesis of invariant residues proline 76 and glycine 77 in this turn were analyzed for the in vivo functionality and level of protein within the cell.	Proline	303-310	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	131-136
9540800-8	1998	The expression of CYP2E1 in the marmoset was confirmed by raising an antibody against the deduced C-terminus of marmoset CYP2E1 (Pro-Arg-Ser-Ser-Val).	Proline	129-132	cytochrome P450 2E1	Callithrix jacchus	18-24
9485403-1	1998	The N-terminal domain of phosphoglycerate kinase (N-PGK) and domain 1 of the T-cell adhesion protein CD2 (CD2.d1) fold through rapidly formed and transiently populated intermediate states in reactions which have no kinetic complications arising from proline isomerization or disulfide bonding.	Proline	250-257	CD2 molecule	Homo sapiens	101-104
9485403-1	1998	The N-terminal domain of phosphoglycerate kinase (N-PGK) and domain 1 of the T-cell adhesion protein CD2 (CD2.d1) fold through rapidly formed and transiently populated intermediate states in reactions which have no kinetic complications arising from proline isomerization or disulfide bonding.	Proline	250-257	CD2 molecule	Homo sapiens	106-112
9484780-3	1998	Grb2 binds proline-rich motifs in Shb via its SH3 domains.	Proline	11-18	growth factor receptor bound protein 2	Homo sapiens	0-4
9484780-3	1998	Grb2 binds proline-rich motifs in Shb via its SH3 domains.	Proline	11-18	SH2 domain containing adaptor protein B	Homo sapiens	34-37
9540800-8	1998	The expression of CYP2E1 in the marmoset was confirmed by raising an antibody against the deduced C-terminus of marmoset CYP2E1 (Pro-Arg-Ser-Ser-Val).	Proline	129-132	cytochrome P450 2E1	Callithrix jacchus	121-127
9480844-0	1998	Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation.	Proline	69-76	D-dopachrome tautomerase	Homo sapiens	27-51
9473309-6	1998	Based on these results, Ile-114, Arg-120, Ser-221, Ser-294, Ile-363, and Val-367 in cytochrome P450 2B4 were replaced simultaneously with Phe, His, Pro, Thr, Val, and Ala, respectively, from 2B5.	Proline	148-151	cytochrome P450 2B4	Oryctolagus cuniculus	84-103
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Proline	107-110	angiotensin I converting enzyme	Homo sapiens	242-245
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Proline	107-110	kininogen 1	Homo sapiens	294-304
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Proline	107-110	angiotensin I converting enzyme	Homo sapiens	337-340
9553770-9	1998	PRCP cleaves only peptides with a penultimate Pro residue (e.g. des-Arg9-bradykinin, angiotensin II).	Proline	46-49	prolylcarboxypeptidase	Homo sapiens	0-4
9452513-3	1998	Microtubules and Grb2 bind to the carboxyl-terminal proline/arginine-rich domain (PRD), whereas phosphoinositides bind to the pleckstrin homology (PH) domain.	Proline	52-59	growth factor receptor bound protein 2	Homo sapiens	17-21
9473484-2	1998	Recent studies have revealed that profilin interacts with VASP, Mena, Bnilp, Bnrlp, and mDia, all of which have the proline-rich domain.	Proline	116-123	vasodilator-stimulated phosphoprotein	Rattus norvegicus	58-62
9526102-0	1998	The simplest proline-containing peptides PG, GP, PGP, and GPGG: regulatory activity and possible sources of biosynthesis.	Proline	13-20	phosphoglycolate phosphatase	Homo sapiens	49-52
9526102-1	1998	Our own data and data from the literature on the regulatory role of the simplest proline-containing peptides GP, PG, PGP, GPGG, and cyclic-PG are summarized.	Proline	81-88	phosphoglycolate phosphatase	Homo sapiens	117-120
9538196-5	1998	Moreover, prior feeding of the proline analog L-azetidine 2-carboxylic acid abrogated the CHX-induced suppression of hsp gene expression.	Proline	31-38	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	117-120
9443070-0	1998	Disruption of a putative SH3 domain and the proline-rich motifs in the 53-kDa substrate of the insulin receptor kinase does not alter its subcellular localization or ability to serve as a substrate.	Proline	44-51	insulin receptor	Mus musculus	95-111
9443918-8	1998	These data indicate that PTP1B exerts its inhibitory effects via proline-dependent interactions with one or more critical components of the adhesion-dependent signaling apparatus, and suggest that one of these components may be p130Cas.	Proline	65-72	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	25-30
9490753-0	1998	Developmental and Hormonal Regulation of Genes Coding for Proline-Rich Proteins in Female Inflorescences and Kernels of Maize The pattern of expression of two genes coding for proteins rich in proline, HyPRP (hybrid proline-rich protein) and HRGP (hydroxyproline-rich glycoprotein), has been studied in maize (Zea mays) embryos by RNA analysis and in situ hybridization.	Proline	58-65	uncharacterized protein LOC100283347	Zea mays	202-207
9490753-0	1998	Developmental and Hormonal Regulation of Genes Coding for Proline-Rich Proteins in Female Inflorescences and Kernels of Maize The pattern of expression of two genes coding for proteins rich in proline, HyPRP (hybrid proline-rich protein) and HRGP (hydroxyproline-rich glycoprotein), has been studied in maize (Zea mays) embryos by RNA analysis and in situ hybridization.	Proline	58-65	uncharacterized LOC100283196	Zea mays	216-236
9490753-0	1998	Developmental and Hormonal Regulation of Genes Coding for Proline-Rich Proteins in Female Inflorescences and Kernels of Maize The pattern of expression of two genes coding for proteins rich in proline, HyPRP (hybrid proline-rich protein) and HRGP (hydroxyproline-rich glycoprotein), has been studied in maize (Zea mays) embryos by RNA analysis and in situ hybridization.	Proline	193-200	uncharacterized LOC100283196	Zea mays	216-236
9442105-13	1998	Results from this study provide the first identification of a ligand for an FKBP in the secretory pathway and suggest that the prolyl cis-trans isomerase activity of FKBP65 may be important for the proper folding of the proline-rich tropoelastin molecule before secretion.	Proline	220-227	elastin	Bos taurus	233-245
9443918-5	1998	The inhibition of adhesion-dependent MAP kinase activation by PTP1B required an intact proline-rich region in the carboxyl terminus of PTP1B, a region we have shown to mediate binding to the Src-homology 3 (SH3) domain of p130Cas [1].	Proline	87-94	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	62-67
9443918-5	1998	The inhibition of adhesion-dependent MAP kinase activation by PTP1B required an intact proline-rich region in the carboxyl terminus of PTP1B, a region we have shown to mediate binding to the Src-homology 3 (SH3) domain of p130Cas [1].	Proline	87-94	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	135-140
9448728-9	1998	It is concluded that the initial steps of the PGHS-2- and PGHS-1-catalyzed oxygenations proceed with identical stereochemistry and involve stereospecific removal of the pro-S hydrogen from the omega 8-methylene group of the substrate.	Proline	169-174	prostaglandin-endoperoxide synthase 2	Homo sapiens	46-52
9436983-6	1998	The bromodomain and the C/H2 domain of p300 mediate the binding to ATF-2, which in turn requires a proline-rich region between amino acids 112 and 350 for its interaction with p300.	Proline	99-106	E1A binding protein p300	Homo sapiens	39-43
9436983-6	1998	The bromodomain and the C/H2 domain of p300 mediate the binding to ATF-2, which in turn requires a proline-rich region between amino acids 112 and 350 for its interaction with p300.	Proline	99-106	activating transcription factor 2	Homo sapiens	67-72
9436983-6	1998	The bromodomain and the C/H2 domain of p300 mediate the binding to ATF-2, which in turn requires a proline-rich region between amino acids 112 and 350 for its interaction with p300.	Proline	99-106	E1A binding protein p300	Homo sapiens	176-180
9442051-8	1998	The defect in spermidine transport was more pronounced in NH4(+)- than proline-grown npr1 cells, suggesting that NPR1 protects against nitrogen catabolite repression of polyamine uptake activity.	Proline	71-78	serine/threonine protein kinase NPR1	Saccharomyces cerevisiae S288C	85-89
9442051-8	1998	The defect in spermidine transport was more pronounced in NH4(+)- than proline-grown npr1 cells, suggesting that NPR1 protects against nitrogen catabolite repression of polyamine uptake activity.	Proline	71-78	serine/threonine protein kinase NPR1	Saccharomyces cerevisiae S288C	113-117
9435213-1	1998	Residue-specific bioincorporation of 1,3-thiazolidine-4-carboxylic acid [thiaproline, Pro(S)], a non-natural amino acid analog of proline, into human recombinant annexin V was achieved with a proline-auxotrophic Escherichia coli strain by fermentation procedures in minimal medium.	Proline	86-92	annexin A5	Homo sapiens	162-171
9448728-9	1998	It is concluded that the initial steps of the PGHS-2- and PGHS-1-catalyzed oxygenations proceed with identical stereochemistry and involve stereospecific removal of the pro-S hydrogen from the omega 8-methylene group of the substrate.	Proline	169-174	prostaglandin-endoperoxide synthase 1	Homo sapiens	58-64
9469938-1	1998	TESK1 (testis-specific protein kinase 1) is a protein serine-threonine kinase, containing characteristic structural features composed of an N-terminal kinase domain and a C-terminal proline-rich domain.	Proline	182-189	testis specific protein kinase 1	Mus musculus	0-5
9469938-1	1998	TESK1 (testis-specific protein kinase 1) is a protein serine-threonine kinase, containing characteristic structural features composed of an N-terminal kinase domain and a C-terminal proline-rich domain.	Proline	182-189	testis specific protein kinase 1	Mus musculus	7-39
9422760-8	1998	Alanine scanning of a peptide derived from the COOH-terminal proline-rich domain of PTP HSCF revealed that a subset of prolines, as well as other residues, was required for efficient binding to PST PIP, and introduction of alanines at some of these positions in the protein resulted in decreased binding to PST PIP in vitro and in vivo.	Proline	119-127	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	194-201
9422736-3	1998	POB1 consists of 521 amino acids, shares a homology with Eps15, which has been identified as an epidermal growth factor (EGF) receptor substrate, and has two proline-rich motifs.	Proline	158-165	RALBP1 associated Eps domain containing 2	Homo sapiens	0-4
9422760-10	1998	Thus, the interaction between PTP HSCF and PST PIP is mediated by a novel site in the cytoskeletal associated protein which interacts with residues within the proline-rich COOH terminus of the phosphatase.	Proline	159-166	protein tyrosine phosphatase non-receptor type 18	Homo sapiens	30-38
9422760-2	1998	Previously, we demonstrated that the PEST-type protein-tyrosine phosphatase, PTP HSCF (hematopoietic stem cell fraction), bound to a novel cytoskeletal associated protein, proline serine threonine phosphatase interacting protein (PST PIP), via an interaction between the proline-rich COOH terminus of the PTP and a site within the putative coiled-coil domain of PST PIP.	Proline	172-179	protein tyrosine phosphatase non-receptor type 18	Homo sapiens	77-85
9422760-2	1998	Previously, we demonstrated that the PEST-type protein-tyrosine phosphatase, PTP HSCF (hematopoietic stem cell fraction), bound to a novel cytoskeletal associated protein, proline serine threonine phosphatase interacting protein (PST PIP), via an interaction between the proline-rich COOH terminus of the PTP and a site within the putative coiled-coil domain of PST PIP.	Proline	172-179	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	230-237
9422760-2	1998	Previously, we demonstrated that the PEST-type protein-tyrosine phosphatase, PTP HSCF (hematopoietic stem cell fraction), bound to a novel cytoskeletal associated protein, proline serine threonine phosphatase interacting protein (PST PIP), via an interaction between the proline-rich COOH terminus of the PTP and a site within the putative coiled-coil domain of PST PIP.	Proline	172-179	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	362-369
9422738-7	1998	Only PC2, but not furin or PC1/PC3, could cleave the Arg-Pro bond to yield Dyn 1-8.	Proline	57-60	proprotein convertase subtilisin/kexin type 2	Homo sapiens	5-8
9422760-10	1998	Thus, the interaction between PTP HSCF and PST PIP is mediated by a novel site in the cytoskeletal associated protein which interacts with residues within the proline-rich COOH terminus of the phosphatase.	Proline	159-166	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	43-50
9422760-2	1998	Previously, we demonstrated that the PEST-type protein-tyrosine phosphatase, PTP HSCF (hematopoietic stem cell fraction), bound to a novel cytoskeletal associated protein, proline serine threonine phosphatase interacting protein (PST PIP), via an interaction between the proline-rich COOH terminus of the PTP and a site within the putative coiled-coil domain of PST PIP.	Proline	271-278	protein tyrosine phosphatase non-receptor type 18	Homo sapiens	77-85
9422760-2	1998	Previously, we demonstrated that the PEST-type protein-tyrosine phosphatase, PTP HSCF (hematopoietic stem cell fraction), bound to a novel cytoskeletal associated protein, proline serine threonine phosphatase interacting protein (PST PIP), via an interaction between the proline-rich COOH terminus of the PTP and a site within the putative coiled-coil domain of PST PIP.	Proline	271-278	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	230-237
9422760-2	1998	Previously, we demonstrated that the PEST-type protein-tyrosine phosphatase, PTP HSCF (hematopoietic stem cell fraction), bound to a novel cytoskeletal associated protein, proline serine threonine phosphatase interacting protein (PST PIP), via an interaction between the proline-rich COOH terminus of the PTP and a site within the putative coiled-coil domain of PST PIP.	Proline	271-278	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	362-369
9422760-8	1998	Alanine scanning of a peptide derived from the COOH-terminal proline-rich domain of PTP HSCF revealed that a subset of prolines, as well as other residues, was required for efficient binding to PST PIP, and introduction of alanines at some of these positions in the protein resulted in decreased binding to PST PIP in vitro and in vivo.	Proline	61-68	protein tyrosine phosphatase non-receptor type 18	Homo sapiens	84-92
9422767-0	1998	Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells.	Proline	68-75	dynamin 1 like	Homo sapiens	0-6
9422767-4	1998	Dymple lacks a proline-rich carboxyl-terminal domain through which dynamin binds to SH3 domains to be activated.	Proline	15-22	dynamin 1 like	Homo sapiens	0-6
9422760-8	1998	Alanine scanning of a peptide derived from the COOH-terminal proline-rich domain of PTP HSCF revealed that a subset of prolines, as well as other residues, was required for efficient binding to PST PIP, and introduction of alanines at some of these positions in the protein resulted in decreased binding to PST PIP in vitro and in vivo.	Proline	61-68	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	194-201
9422760-8	1998	Alanine scanning of a peptide derived from the COOH-terminal proline-rich domain of PTP HSCF revealed that a subset of prolines, as well as other residues, was required for efficient binding to PST PIP, and introduction of alanines at some of these positions in the protein resulted in decreased binding to PST PIP in vitro and in vivo.	Proline	119-127	protein tyrosine phosphatase non-receptor type 18	Homo sapiens	84-92
9823470-7	1998	Cortactin contains (i) a filamentous actin binding tandem repeat domain, (ii) a proline-rich SH3-binding and (iii) a SH3 domain that is common in proteins involved in signal transduction.	Proline	80-87	cortactin	Homo sapiens	0-9
9923703-5	1998	Triple resonance experiments that detect the 1H alpha chemical shift were necessary to complete the chemical shift assignment, owing to the large number of proline residues in this fragment of rNedd4.	Proline	156-163	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	193-199
9622938-1	1998	delta 1-pyrroline 5-carboxylate synthetase (P5C synthetase) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamate semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	Proline	199-206	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-42
9461419-6	1998	Contig construction for the sheep cathelicidin gene family demonstrates that three genes, OaDodeA, OaDodeB, and OaMAP-34, are present head-to-tail in a 14.5 kb region, and that four proline/arginine-rich genes, OaBac5, OaBac7.5, OaBac11, and OaBac6, are arranged head-to-tail in a region covering 30.5 kb.	Proline	182-189	cathelicidin-7	Ovis aries	112-120
9865467-0	1998	Ser752 mutation to Pro or Ala in the beta3 integrin subunit differentially affects the kinetics of cell spreading to von Willebrand factor and fibrinogen.	Proline	19-22	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	37-42
9865467-0	1998	Ser752 mutation to Pro or Ala in the beta3 integrin subunit differentially affects the kinetics of cell spreading to von Willebrand factor and fibrinogen.	Proline	19-22	von Willebrand factor	Homo sapiens	117-138
9865467-0	1998	Ser752 mutation to Pro or Ala in the beta3 integrin subunit differentially affects the kinetics of cell spreading to von Willebrand factor and fibrinogen.	Proline	19-22	fibrinogen beta chain	Homo sapiens	143-153
9761683-10	1998	In addition, TcTIM has proline at position 24 in the first helix of the TIM barrel; this is absent in the other TIM.	Proline	23-30	triosephosphate isomerase 1	Homo sapiens	15-18
9502319-11	1998	Interface formation in a folding intermediate of the scFv fragment is proposed to prevent the back-isomerization of these prolines from being efficiently catalyzed by cyclophilin.	Proline	122-130	immunglobulin heavy chain variable region	Homo sapiens	53-57
9735375-10	1998	The predicted proline-rich AIRE polypeptide harbours two PHD-type zinc finger motifs and contains a putative nuclear targeting signal suggesting its involvement in the regulation of transcription.	Proline	14-21	autoimmune regulator	Homo sapiens	27-31
9551977-4	1998	Previously, we showed that the PU.1 PEST domain (rich in the amino acids proline, glutamate, serine, and threonine; sequences 118-160) is necessary for Pip recruitment to DNA.	Proline	73-80	Spi-1 proto-oncogene	Homo sapiens	31-35
9551977-4	1998	Previously, we showed that the PU.1 PEST domain (rich in the amino acids proline, glutamate, serine, and threonine; sequences 118-160) is necessary for Pip recruitment to DNA.	Proline	73-80	prolactin induced protein	Homo sapiens	152-155
9761683-10	1998	In addition, TcTIM has proline at position 24 in the first helix of the TIM barrel; this is absent in the other TIM.	Proline	23-30	triosephosphate isomerase 1	Homo sapiens	72-75
9659915-2	1998	We have purified and cloned a new class of Rho-p21 guanine nucleotide exchange factor binding tightly through its N-terminal SH3 domain to a conserved proline-rich PAK sequence with a Kd of 24 nM.	Proline	151-158	H3 histone pseudogene 16	Homo sapiens	47-50
9418872-2	1998	This interaction is mediated by a proline-rich sequence on PTP1B and the SH3 domain on p130Cas.	Proline	34-41	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	59-64
9418872-2	1998	This interaction is mediated by a proline-rich sequence on PTP1B and the SH3 domain on p130Cas.	Proline	34-41	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	87-94
9492532-11	1998	PR-39 is a proline-rich antimicrobial peptide which was isolated from a pig small intestine and has been reported to induced syndecan-1 on mouse mesenchymal cells.	Proline	11-18	antibacterial protein PR-39	Sus scrofa	0-5
9972056-2	1998	Synthesis of proline analogue of anthraquinone-2-carboxylic acid and its susceptibility to the action of prolidase.	Proline	13-20	peptidase D	Homo sapiens	105-114
9405433-4	1997	We show that the mouse ubiquitin-specific protease Unp, and its human homolog Unph, can efficiently cleave the ubiquitin-proline bond in ubiquitin fusion proteins of different sizes.	Proline	121-128	ubiquitin specific peptidase 4 (proto-oncogene)	Mus musculus	51-54
9972056-4	1998	The synthesis of proline analogue of anthraquinone-2-carboxylic acid (potential antineoplastic agent) conjugated through imido-bond (potential target for prolidase action) has been performed.	Proline	17-24	peptidase D	Homo sapiens	154-163
9972056-8	1998	Although insolubility of the proline analogue of anthraquinone-2-carboxylic acid in aqueous solutions limit its potential therapeutic value, the presented data suggest that prolidase may have a broader substrate specificity than thought previously.	Proline	29-36	peptidase D	Homo sapiens	173-182
9405039-8	1997	Proline in the -1 or +1 position has a deleterious effect and inhibits phosphorylation by gamma-PAK.	Proline	0-7	p21 (RAC1) activated kinase 2	Homo sapiens	90-99
9407065-0	1997	The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.	Proline	52-59	amyloid beta precursor protein binding family B member 1	Homo sapiens	32-36
9407065-0	1997	The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.	Proline	52-59	ENAH actin regulator	Homo sapiens	75-79
9407065-4	1997	Proline-rich sequences sharing a proline-proline-leucine-proline core motif were recovered by screening expression libraries for ligands of the FE65 WW domain.	Proline	0-7	amyloid beta precursor protein binding family B member 1	Homo sapiens	144-148
9407065-4	1997	Proline-rich sequences sharing a proline-proline-leucine-proline core motif were recovered by screening expression libraries for ligands of the FE65 WW domain.	Proline	33-40	amyloid beta precursor protein binding family B member 1	Homo sapiens	144-148
9407065-4	1997	Proline-rich sequences sharing a proline-proline-leucine-proline core motif were recovered by screening expression libraries for ligands of the FE65 WW domain.	Proline	41-48	amyloid beta precursor protein binding family B member 1	Homo sapiens	144-148
9407065-4	1997	Proline-rich sequences sharing a proline-proline-leucine-proline core motif were recovered by screening expression libraries for ligands of the FE65 WW domain.	Proline	41-48	amyloid beta precursor protein binding family B member 1	Homo sapiens	144-148
9407065-7	1997	Using the SPOTs technique of peptide synthesis, we identified the sequences in Mena that interact with the FE65 WW domain and found that they contain the signature proline-proline-leucine-proline motif.	Proline	164-171	ENAH actin regulator	Homo sapiens	79-83
9407065-7	1997	Using the SPOTs technique of peptide synthesis, we identified the sequences in Mena that interact with the FE65 WW domain and found that they contain the signature proline-proline-leucine-proline motif.	Proline	164-171	amyloid beta precursor protein binding family B member 1	Homo sapiens	107-111
9407065-7	1997	Using the SPOTs technique of peptide synthesis, we identified the sequences in Mena that interact with the FE65 WW domain and found that they contain the signature proline-proline-leucine-proline motif.	Proline	172-179	ENAH actin regulator	Homo sapiens	79-83
9407065-7	1997	Using the SPOTs technique of peptide synthesis, we identified the sequences in Mena that interact with the FE65 WW domain and found that they contain the signature proline-proline-leucine-proline motif.	Proline	172-179	amyloid beta precursor protein binding family B member 1	Homo sapiens	107-111
9407065-7	1997	Using the SPOTs technique of peptide synthesis, we identified the sequences in Mena that interact with the FE65 WW domain and found that they contain the signature proline-proline-leucine-proline motif.	Proline	172-179	ENAH actin regulator	Homo sapiens	79-83
9407065-7	1997	Using the SPOTs technique of peptide synthesis, we identified the sequences in Mena that interact with the FE65 WW domain and found that they contain the signature proline-proline-leucine-proline motif.	Proline	172-179	amyloid beta precursor protein binding family B member 1	Homo sapiens	107-111
9405433-4	1997	We show that the mouse ubiquitin-specific protease Unp, and its human homolog Unph, can efficiently cleave the ubiquitin-proline bond in ubiquitin fusion proteins of different sizes.	Proline	121-128	ubiquitin specific peptidase 4	Homo sapiens	78-82
9405440-2	1997	We have recently demonstrated an association between the WW domains of Nedd4 and the proline-rich PY motifs (XPPXY) of the epithelial Na+ channel, as well as with PY motifs of several other proteins.	Proline	85-92	NEDD4 E3 ubiquitin protein ligase	Canis lupus familiaris	71-76
9398320-6	1997	We present here evidence that cdc2 kinase is the major M-phase MAP4 kinase, and, further, we identify two phosphorylation sites within the proline-rich domain of MAP4.	Proline	139-146	cyclin dependent kinase 1	Homo sapiens	30-34
9440875-0	1997	Enhancing the activity of protein C by mutagenesis to improve the membrane-binding site: studies related to proline-10.	Proline	108-115	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	26-35
9440875-2	1997	A proposed membrane contact site and mechanism suggested that this difference was largely due to the presence of proline at position 10 of bovine protein C versus histidine at position 10 of human protein C [McDonald, J.F., Shah, A.M., Schwalbe, R.A., Kisiel, W., Dahlback, B., and Nelsestuen, G.L.	Proline	113-120	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	146-155
9440875-5	1997	In both cases, the protein containing proline-10 showed lower membrane affinity, about 10-fold lower for bovine protein C and 5-fold lower for human protein C.	Proline	38-45	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	112-121
9440875-5	1997	In both cases, the protein containing proline-10 showed lower membrane affinity, about 10-fold lower for bovine protein C and 5-fold lower for human protein C.	Proline	38-45	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	149-158
9440875-6	1997	As expected, activated human protein C (hAPC) containing proline at position 10 showed 2.4-3.5-fold lower activity than wild type hAPC, depending on the assay used.	Proline	57-64	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	29-38
9425254-0	1997	Roles for proline-rich regions of p47phox and p67phox in the phagocyte NADPH oxidase activation in vitro.	Proline	10-17	neutrophil cytosolic factor 1	Homo sapiens	34-41
9425254-0	1997	Roles for proline-rich regions of p47phox and p67phox in the phagocyte NADPH oxidase activation in vitro.	Proline	10-17	neutrophil cytosolic factor 2	Homo sapiens	46-53
9398320-6	1997	We present here evidence that cdc2 kinase is the major M-phase MAP4 kinase, and, further, we identify two phosphorylation sites within the proline-rich domain of MAP4.	Proline	139-146	microtubule associated protein 4	Homo sapiens	162-166
9425254-2	1997	Here we focus on roles of proline-rich regions (PRRs) that reside in p47phox and p67phox.	Proline	26-33	neutrophil cytosolic factor 1	Homo sapiens	69-76
9425254-2	1997	Here we focus on roles of proline-rich regions (PRRs) that reside in p47phox and p67phox.	Proline	26-33	neutrophil cytosolic factor 2	Homo sapiens	81-88
9398320-10	1997	Ser-696 and Ser-787, both of which lie within SPXK consensus sequences for cdc2 kinase, were identified as phosphorylation sites in the proline-rich region of MAP4 in vivo and in vitro.	Proline	136-143	cyclin dependent kinase 1	Homo sapiens	75-79
9398320-10	1997	Ser-696 and Ser-787, both of which lie within SPXK consensus sequences for cdc2 kinase, were identified as phosphorylation sites in the proline-rich region of MAP4 in vivo and in vitro.	Proline	136-143	microtubule associated protein 4	Homo sapiens	159-163
9398241-3	1997	Peptidyl prolyl cis-trans isomerase (cyclophilin), which has been shown to catalyze the slow folding reactions of some proteins, was employed to determine which of the refolding reactions of SNase and P117G SNase involve proline isomerization.	Proline	221-228	peptidylprolyl isomerase like 1	Homo sapiens	0-35
9395400-3	1997	Pin1 is here shown to be a phosphorylation-dependent PPIase that specifically recognizes the phosphoserine-proline or phosphothreonine-proline bonds present in mitotic phosphoproteins.	Proline	107-114	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
9395400-3	1997	Pin1 is here shown to be a phosphorylation-dependent PPIase that specifically recognizes the phosphoserine-proline or phosphothreonine-proline bonds present in mitotic phosphoproteins.	Proline	107-114	FKBP prolyl isomerase 7	Homo sapiens	53-59
9395400-3	1997	Pin1 is here shown to be a phosphorylation-dependent PPIase that specifically recognizes the phosphoserine-proline or phosphothreonine-proline bonds present in mitotic phosphoproteins.	Proline	135-142	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
9395400-3	1997	Pin1 is here shown to be a phosphorylation-dependent PPIase that specifically recognizes the phosphoserine-proline or phosphothreonine-proline bonds present in mitotic phosphoproteins.	Proline	135-142	FKBP prolyl isomerase 7	Homo sapiens	53-59
9395400-4	1997	Both Pin1 and MPM-2 selected similar phosphorylated serine-proline-containing peptides, providing the basis for the specific interaction between Pin1 and MPM-2 antigens.	Proline	59-66	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	5-9
9395400-4	1997	Both Pin1 and MPM-2 selected similar phosphorylated serine-proline-containing peptides, providing the basis for the specific interaction between Pin1 and MPM-2 antigens.	Proline	59-66	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	145-149
9395400-5	1997	Pin1 preferentially isomerized proline residues preceded by phosphorylated serine or threonine with up to 1300-fold selectivity compared with unphosphorylated peptides.	Proline	31-38	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
9398265-4	1997	Mutant proteins which lacked a free N-terminal proline residue were enzymatically inactive, as was a preparation of native MIF modified covalently at its N terminus by 3-bromopyruvate, suggesting that this proline has a catalytic function.	Proline	206-213	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	123-126
9395400-6	1997	Pin1 may thus regulate mitotic progression by catalyzing sequence-specific and phosphorylation-dependent proline isomerization.	Proline	105-112	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
9388224-8	1997	Protein binding assays demonstrated that among the major src homology 3-proteins known to bind to the proline-rich region of synaptojanin 1, Grb2, amphiphysin, and members of SH3p4/8/13 protein family, only Grb2 bound to that of synaptojanin 2.	Proline	102-109	synaptojanin 1	Homo sapiens	125-139
9388224-8	1997	Protein binding assays demonstrated that among the major src homology 3-proteins known to bind to the proline-rich region of synaptojanin 1, Grb2, amphiphysin, and members of SH3p4/8/13 protein family, only Grb2 bound to that of synaptojanin 2.	Proline	102-109	growth factor receptor bound protein 2	Homo sapiens	141-145
9388224-8	1997	Protein binding assays demonstrated that among the major src homology 3-proteins known to bind to the proline-rich region of synaptojanin 1, Grb2, amphiphysin, and members of SH3p4/8/13 protein family, only Grb2 bound to that of synaptojanin 2.	Proline	102-109	growth factor receptor bound protein 2	Homo sapiens	207-211
9388224-8	1997	Protein binding assays demonstrated that among the major src homology 3-proteins known to bind to the proline-rich region of synaptojanin 1, Grb2, amphiphysin, and members of SH3p4/8/13 protein family, only Grb2 bound to that of synaptojanin 2.	Proline	102-109	synaptojanin 2	Homo sapiens	229-243
9388224-10	1997	This observation suggests that the proline-rich regions of synaptojanins 1 and 2 are implicated in different protein-protein interactions and direct the two isoforms to different subcellular compartments.	Proline	35-42	synaptojanin 1	Homo sapiens	59-80
9450672-3	1997	The epitopes of the six mAbs were found to be concentrated in the N-terminal region within domains A and B for the synapsin II-reactive mAbs 19.4, 19.11, 19.51 and 19.21, and in two C-terminal clusters in the proline-rich domains D for synapsin I (mAbs 10.22, 19.51, 19.11 and 19.8) and G for synapsin II (mAb 19.8).	Proline	209-216	synapsin II	Homo sapiens	115-126
18031104-2	1997	Recombinant human IL-11 (rhIL-11; oprelvekin) is produced in Escherichia coli and differs from the naturally occurring protein only in the absence of the amino-terminal proline residue.	Proline	169-176	interleukin 11	Homo sapiens	18-23
18031104-2	1997	Recombinant human IL-11 (rhIL-11; oprelvekin) is produced in Escherichia coli and differs from the naturally occurring protein only in the absence of the amino-terminal proline residue.	Proline	169-176	interleukin 11	Homo sapiens	34-44
9435528-4	1997	Enzymatic degradation of TRH in vivo produces other bioactive peptides such as cyclo(His-Pro).	Proline	89-92	thyrotropin releasing hormone	Rattus norvegicus	25-28
9435528-7	1997	TRH and its metabolite cyclo(His-Pro) dose dependently inhibited 2-deoxy-D-glucose (2-DG)-stimulated pancreatic secretion.	Proline	33-36	thyrotropin releasing hormone	Rattus norvegicus	0-3
9450672-3	1997	The epitopes of the six mAbs were found to be concentrated in the N-terminal region within domains A and B for the synapsin II-reactive mAbs 19.4, 19.11, 19.51 and 19.21, and in two C-terminal clusters in the proline-rich domains D for synapsin I (mAbs 10.22, 19.51, 19.11 and 19.8) and G for synapsin II (mAb 19.8).	Proline	209-216	synapsin I	Homo sapiens	115-125
9375655-7	1997	We also show that alteration of highly conserved proline residues in UNC-9 leads to a cold sensitivity that likely affects a step in protein expression rather than function.	Proline	49-56	Innexin;Innexin unc-9	Caenorhabditis elegans	69-74
9428692-3	1997	We show that interaction between Stat 5B and the receptor requires a functional insulin-receptor kinase, Tyr960 of insulin receptor is implicated in the interaction with Stat 5B, whereas asparagine and proline forming the NPEY960-motif are not, and Stat 5B mutated at Thr684, a potential phosphorylation site of mitogen-activated protein kinase, loses its ability to interact with the insulin receptor.	Proline	202-209	signal transducer and activator of transcription 5B	Homo sapiens	33-40
9428692-3	1997	We show that interaction between Stat 5B and the receptor requires a functional insulin-receptor kinase, Tyr960 of insulin receptor is implicated in the interaction with Stat 5B, whereas asparagine and proline forming the NPEY960-motif are not, and Stat 5B mutated at Thr684, a potential phosphorylation site of mitogen-activated protein kinase, loses its ability to interact with the insulin receptor.	Proline	202-209	insulin	Homo sapiens	80-87
9495283-6	1997	Analysis of point mutations generated by low fidelity PCR within AD2 of HSF1 indicated that hydrophobic and charged amino acids in addition to proline, serine and threonine make critical contributions to transcriptional activity.	Proline	143-150	heat shock transcription factor 1	Homo sapiens	72-76
16501446-3	1997	Recently, the changes of plasma aminoacidograms induced by the administration of high-dose BCAA in sepsis have been better detailed: 1) a tendency to normalization of high levels of proline and of other amino acids transported intracellularly by transport system ""A""; 2) less relevant reduction of the levels of other amino acids; 3) increase of the levels of taurine, glutamate and aspartate; more complex interactions with specific amino acids.	Proline	182-189	AT-rich interaction domain 4B	Homo sapiens	91-95
9398158-1	1997	A proline, a leucine, and two cysteine residues, introduced at positions 19, 28, 31, and 32 of bovine pancreatic RNase A, i.e. the positions occupied by these residues in the subunit of bovine seminal RNase, the only dimeric RNase of the pancreatic-type superfamily, transform monomeric RNase A into a dimeric RNase, endowed with the same ability of BS-RNase of swapping its N-terminal segments.	Proline	2-9	ribonuclease pancreatic	Bos taurus	113-120
9374504-1	1997	We have recently reported (1) that two naturally occurring mutants of the insulin receptor tyrosine kinase domain, Arg-1174 --&gt; Gln and Pro-1178 --&gt; Leu (Gln-1174 and Leu1178, respectively), both found in patients with inherited severe insulin resistance, markedly impaired receptor tyrosine autophosphorylation, with both mutant receptors being unable to mediate the stimulation of glycogen synthesis or mitogenesis by insulin when expressed in Chinese hamster ovary cells.	Proline	139-142	insulin	Homo sapiens	74-81
9374504-1	1997	We have recently reported (1) that two naturally occurring mutants of the insulin receptor tyrosine kinase domain, Arg-1174 --&gt; Gln and Pro-1178 --&gt; Leu (Gln-1174 and Leu1178, respectively), both found in patients with inherited severe insulin resistance, markedly impaired receptor tyrosine autophosphorylation, with both mutant receptors being unable to mediate the stimulation of glycogen synthesis or mitogenesis by insulin when expressed in Chinese hamster ovary cells.	Proline	139-142	insulin	Homo sapiens	242-249
9374504-1	1997	We have recently reported (1) that two naturally occurring mutants of the insulin receptor tyrosine kinase domain, Arg-1174 --&gt; Gln and Pro-1178 --&gt; Leu (Gln-1174 and Leu1178, respectively), both found in patients with inherited severe insulin resistance, markedly impaired receptor tyrosine autophosphorylation, with both mutant receptors being unable to mediate the stimulation of glycogen synthesis or mitogenesis by insulin when expressed in Chinese hamster ovary cells.	Proline	139-142	insulin	Homo sapiens	242-249
9398839-2	1997	We have isolated a novel gene from this region, AIRE (autoimmune regulator), which encodes a protein containing motifs suggestive of a transcription factor including two zinc-finger (PHD-finger) motifs, a proline-rich region and three LXXLL motifs.	Proline	205-212	autoimmune regulator	Homo sapiens	48-52
9398839-2	1997	We have isolated a novel gene from this region, AIRE (autoimmune regulator), which encodes a protein containing motifs suggestive of a transcription factor including two zinc-finger (PHD-finger) motifs, a proline-rich region and three LXXLL motifs.	Proline	205-212	autoimmune regulator	Homo sapiens	54-74
9408950-0	1997	SH3 domain of Bruton"s tyrosine kinase can bind to proline-rich peptides of TH domain of the kinase and p120cbl.	Proline	51-58	Bruton tyrosine kinase	Homo sapiens	14-38
9408950-6	1997	Proline-rich peptides selected from TH domain of BTK and p120cbl were studied.	Proline	0-7	Bruton tyrosine kinase	Homo sapiens	49-52
9414105-6	1997	PPIase was shown to increase the fraction of slowly folding species, thereby competing with the fast folding of short-term denatured scFv, having native proline conformations.	Proline	153-160	peptidylprolyl isomerase like 1	Homo sapiens	0-6
9427531-3	1997	In contrast to LTBP-1 and LTBP-3, mouse LTBP-2 apparently is a more modular protein, with proline/glycine-rich sequences always alternating with clusters of cysteine-rich structural motifs.	Proline	90-97	latent transforming growth factor beta binding protein 2	Mus musculus	40-46
9399639-3	1997	The interaction between Vav and Cbl-b requires the entire SH3-SH2-SH3 carboxy-terminal domain of Vav and a long stretch of proline-rich sequences present in the central region of Cbl-b.	Proline	123-130	vav guanine nucleotide exchange factor 1	Homo sapiens	24-27
9399639-3	1997	The interaction between Vav and Cbl-b requires the entire SH3-SH2-SH3 carboxy-terminal domain of Vav and a long stretch of proline-rich sequences present in the central region of Cbl-b.	Proline	123-130	Cbl proto-oncogene B	Homo sapiens	32-37
9399639-3	1997	The interaction between Vav and Cbl-b requires the entire SH3-SH2-SH3 carboxy-terminal domain of Vav and a long stretch of proline-rich sequences present in the central region of Cbl-b.	Proline	123-130	Cbl proto-oncogene B	Homo sapiens	179-184
9395067-3	1997	In addition to this domain, Rvs167p contains a central glycine-proline-alanine rich domain and a SH3 domain.	Proline	63-70	amphiphysin	Saccharomyces cerevisiae S288C	28-35
9371807-4	1997	Ednrb27Pub mice harbor a mutation at a critical proline residue in the fifth transmembrane domain of the EDNRB protein.	Proline	48-55	endothelin receptor type B	Mus musculus	105-110
9359829-11	1997	Disrupting the N-terminal alpha-helix of Go alpha with a proline point mutation at Arg-9 (R9P) does not affect interactions with G beta gamma on sucrose-density gradients but significantly reduces acceptor membrane binding.	Proline	57-64	tripartite motif containing 47	Homo sapiens	41-49
9393880-7	1997	The presence of the RING-H2 domain, a proline-rich region at the COOH-end, and regions rich in acidic amino acids, leads to the hypothesis that the Praja1 product is possibly involved in mediating protein-protein interactions, possibly as part of a protein sorting or transport pathway.	Proline	38-45	praja ring finger ubiquitin ligase 1	Mus musculus	148-154
9414105-6	1997	PPIase was shown to increase the fraction of slowly folding species, thereby competing with the fast folding of short-term denatured scFv, having native proline conformations.	Proline	153-160	immunglobulin heavy chain variable region	Homo sapiens	133-137
9396628-5	1997	An amino acid replacement at position 33 in the protein improves the growth rate of these cells growing at temperatures above 28 degrees C. This replacement changes a proline to a serine and is a further divergence from both the Tetrahymena thermophila and Saccharomyces cerevisiae histone H4 sequences.	Proline	167-174	histone H4	Saccharomyces cerevisiae S288C	282-292
9581573-3	1997	It has recently become clear that the role of profilin in the cell is more complex, perhaps due to interactions with polyphosphoinositides and proline-rich proteins, or due to the ability to lower the critical concentration for actin assembly at the fast-growing barbed end of actin filaments.	Proline	143-150	profilin-4	Zea mays	46-54
9427525-5	1997	The cytoplasmic domain of Sema Z was found to be rich in prolines.	Proline	57-65	semaphorin 6B	Rattus norvegicus	26-32
9520124-4	1997	We also determined that r-apo(a) binds directly to a synthetic apoB peptide spanning amino acid residues 3732-3745; this interaction appeared to be mediated by sequences present in apo(a) kringle IV types 8 and 9, and could be inhibited by arginine, lysine and proline.	Proline	261-268	apolipoprotein B	Homo sapiens	63-67
9347802-0	1997	An alanine to proline mutation in the 1A rod domain of the keratin 10 chain in epidermolytic hyperkeratosis.	Proline	14-21	keratin 10	Homo sapiens	59-69
9328822-1	1997	Prolidase (EC 3.4.13.9) is a ubiquitously distributed imidodipeptidase that catalyzes the hydrolysis of C-terminal proline or hydroxyproline containing dipeptides.	Proline	115-122	peptidase D	Homo sapiens	0-9
9402469-6	1997	Unexpectedly, a rabphilin 3a deletion mutant missing the Rab 3 binding domain was also stimulatory on secretion, although a further deletion of rabphilin to exclude the first of the two proline-rich regions abolished its stimulatory effect.	Proline	186-193	rabphilin 3A	Homo sapiens	16-28
9402469-7	1997	The first of these two mutants was primarily particulate, while the second mutant was primarily soluble, suggesting that the first proline-rich region of rabphilin 3a plays a role in targeting rabphilin to its site of action.	Proline	131-138	rabphilin 3A	Homo sapiens	154-166
9434806-0	1997	Safety and efficacy of [Lys(B28), Pro(B29)]-human insulin in patients with diabetes mellitus.	Proline	34-37	insulin	Homo sapiens	50-57
9347802-1	1997	We report a mutation in a case of epidermolytic hyperkeratosis that results in a proline for alanine substitution in the residue position 12 of the 1A subdomain of the keratin 10 chain (codon 158).	Proline	81-88	keratin 10	Homo sapiens	168-178
9385632-2	1997	We demonstrate that the capsid sequence 87His-Ala-Gly-Pro-Ile-Ala92 (87HAGPIA92) encompasses the primary cyclophilin A binding site and present an X-ray crystal structure of the CypA/HAGPIA complex.	Proline	54-57	peptidylprolyl isomerase A	Homo sapiens	105-118
9379039-2	1997	The three-dimensional structure of the FcRn suggested that a substitution of the conserved valine at position 165 of the alpha2 helix by proline contributed to a kink in the position of this helix relative to the alpha1 helix, and resulted in closing of the potential peptide-binding cleft.	Proline	137-144	Fc fragment of IgG receptor and transporter	Mus musculus	39-43
9379039-6	1997	Thus, the proline substitution at position 165 of FcRn and some other class I-like molecules is not the sole cause of the lack of peptide presentation.	Proline	10-17	Fc fragment of IgG receptor and transporter	Mus musculus	50-54
9343258-3	1997	A single mutation within the central proline-rich region of Tax-2 disrupted the transactivation of the NF-kappaB/Rel pathway.	Proline	37-44	nuclear factor kappa B subunit 1	Homo sapiens	103-112
9418048-3	1997	The expression of three genes, p5cs, which encodes delta(1)-pyrroline-5-carboxylate synthetase (P5CS), the first enzyme of the proline biosynthesis pathway, rab18 and Iti78 which both encode proteins of unknown function, was induced by mannitol and salt treatments.	Proline	127-134	RAB GTPASE HOMOLOG B18	Arabidopsis thaliana	157-162
9409525-2	1997	The amino acid analysis by high-performance liquid chromatography demonstrated that the umbilical venous/maternal and fetal/maternal ratio of serum proline concentration increased in EGF dose-dependent manner accompanied by the increase in the ratios of total fetal weight and placental weight to maternal body weight gain.	Proline	148-155	epidermal growth factor like 1	Rattus norvegicus	183-186
9409525-3	1997	These results suggested that EGF regulates fetal growth by, as one of its possible mechanism, promoting placental proline supply from mother to fetus.	Proline	114-121	epidermal growth factor like 1	Rattus norvegicus	29-32
9385632-3	1997	In contrast to the cis prolines observed in all previously reported structures of CypA complexed with model peptides, the proline in this peptide, Pro 90, binds the cyclophilin A active site in a trans conformation.	Proline	147-150	peptidylprolyl isomerase A	Homo sapiens	165-178
9385632-5	1997	Comparison with the recently determined structures of CypA in complexes with larger fragments of the HIV-1 capsid protein demonstrates that CypA recognition of these hexapeptides involves contacts with peptide residues Ala(Val) 88, Gly 89, and Pro 90, and is independent of the context of longer sequences.	Proline	244-247	peptidylprolyl isomerase A	Homo sapiens	140-144
9385632-2	1997	We demonstrate that the capsid sequence 87His-Ala-Gly-Pro-Ile-Ala92 (87HAGPIA92) encompasses the primary cyclophilin A binding site and present an X-ray crystal structure of the CypA/HAGPIA complex.	Proline	54-57	peptidylprolyl isomerase A	Homo sapiens	178-182
9385632-3	1997	In contrast to the cis prolines observed in all previously reported structures of CypA complexed with model peptides, the proline in this peptide, Pro 90, binds the cyclophilin A active site in a trans conformation.	Proline	23-30	peptidylprolyl isomerase A	Homo sapiens	165-178
9385632-3	1997	In contrast to the cis prolines observed in all previously reported structures of CypA complexed with model peptides, the proline in this peptide, Pro 90, binds the cyclophilin A active site in a trans conformation.	Proline	147-150	peptidylprolyl isomerase A	Homo sapiens	82-86
9346962-4	1997	SPA-1 cDNA encodes a 130-kDa protein (p130(SPA-1)) consisting of proline-rich regions and rap1GAP-related domain followed by a coiled-coil stretch.	Proline	65-72	signal-induced proliferation-associated 1	Homo sapiens	0-5
9346894-0	1997	FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain.	Proline	66-73	FKBP prolyl isomerase 1A	Homo sapiens	0-6
9346925-5	1997	HPK1 possesses an N-terminal catalytic domain and an extended C-terminal tail with four proline-rich motifs.	Proline	88-95	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	0-4
9346925-6	1997	The SH3 domains of Grb2 bound in vitro to specific proline-rich motifs in the HPK1 tail and functioned synergistically to direct the stable binding of Grb2 to HPK1 in transfected Cos1 cells.	Proline	51-58	growth factor receptor bound protein 2	Homo sapiens	19-23
9346925-6	1997	The SH3 domains of Grb2 bound in vitro to specific proline-rich motifs in the HPK1 tail and functioned synergistically to direct the stable binding of Grb2 to HPK1 in transfected Cos1 cells.	Proline	51-58	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	78-82
9346962-4	1997	SPA-1 cDNA encodes a 130-kDa protein (p130(SPA-1)) consisting of proline-rich regions and rap1GAP-related domain followed by a coiled-coil stretch.	Proline	65-72	signal-induced proliferation-associated 1	Homo sapiens	38-48
9346925-6	1997	The SH3 domains of Grb2 bound in vitro to specific proline-rich motifs in the HPK1 tail and functioned synergistically to direct the stable binding of Grb2 to HPK1 in transfected Cos1 cells.	Proline	51-58	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	159-163
9341137-6	1997	This specificity resides, in part, in the proline-rich domain of VAMP2 as a chimera containing this domain of VAMP2 fused to VAMP1 is able to bind to PRA1.	Proline	42-49	vesicle-associated membrane protein 2	Rattus norvegicus	65-70
9356262-3	1997	We show here that, in addition to its activity in assays with proline-containing tetrapeptides, parvulin catalyzes the proline-limited folding of a variant of ribonuclease T1 with a kcat/Km value of 30,000 M-1 s-1.	Proline	62-69	peptidylprolyl isomerase C	Homo sapiens	96-104
9356262-3	1997	We show here that, in addition to its activity in assays with proline-containing tetrapeptides, parvulin catalyzes the proline-limited folding of a variant of ribonuclease T1 with a kcat/Km value of 30,000 M-1 s-1.	Proline	119-126	peptidylprolyl isomerase C	Homo sapiens	96-104
9341123-3	1997	In addition, the hDlg contains an amino-terminal proline-rich domain that is absent in other MAGUKs.	Proline	49-56	discs large MAGUK scaffold protein 1	Homo sapiens	17-21
9341137-6	1997	This specificity resides, in part, in the proline-rich domain of VAMP2 as a chimera containing this domain of VAMP2 fused to VAMP1 is able to bind to PRA1.	Proline	42-49	vesicle-associated membrane protein 2	Rattus norvegicus	110-115
9341123-10	1997	The p56lck binding site was localized within the amino-terminal segment of hDlg containing proline-rich domain.	Proline	91-98	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-10
9341137-6	1997	This specificity resides, in part, in the proline-rich domain of VAMP2 as a chimera containing this domain of VAMP2 fused to VAMP1 is able to bind to PRA1.	Proline	42-49	vesicle-associated membrane protein 1	Rattus norvegicus	125-130
9341123-10	1997	The p56lck binding site was localized within the amino-terminal segment of hDlg containing proline-rich domain.	Proline	91-98	discs large MAGUK scaffold protein 1	Homo sapiens	75-79
9341137-6	1997	This specificity resides, in part, in the proline-rich domain of VAMP2 as a chimera containing this domain of VAMP2 fused to VAMP1 is able to bind to PRA1.	Proline	42-49	Rab acceptor 1	Rattus norvegicus	150-154
9373179-6	1997	The extended structure of TRAIL-R3 is due to the presence of multiple threonine-, alanine-, proline- and glutamine-rich repeats (TAPE repeats).	Proline	92-99	TNF receptor superfamily member 10c	Homo sapiens	26-34
9342364-11	1997	Notably, this RA-signaled cyclin D1 proteolysis depended on the C-terminal PEST sequence, a region rich in proline (P), glutamate (E), serine (S), and threonine (T).	Proline	107-114	cyclin D1	Homo sapiens	26-35
9342381-4	1997	The interaction was mediated by the proline-rich domain D of synapsin I and was not significantly affected by stoichiometric phosphorylation of synapsin I at any of the known regulatory sites.	Proline	36-43	synapsin I	Rattus norvegicus	61-71
9344857-3	1997	A novel molecule detected therefrom (referred to as Nck-, Ash- and phospholipase Cgamma-binding protein 4) contained proline-rich sequences and, through the function of one of them, interacted with the middle SH3 domain of Nck.	Proline	117-124	NCK adaptor protein 1	Homo sapiens	52-55
9344857-3	1997	A novel molecule detected therefrom (referred to as Nck-, Ash- and phospholipase Cgamma-binding protein 4) contained proline-rich sequences and, through the function of one of them, interacted with the middle SH3 domain of Nck.	Proline	117-124	NCK adaptor protein 1	Homo sapiens	223-226
9344857-3	1997	A novel molecule detected therefrom (referred to as Nck-, Ash- and phospholipase Cgamma-binding protein 4) contained proline-rich sequences and, through the function of one of them, interacted with the middle SH3 domain of Nck.	Proline	117-124	growth factor receptor bound protein 2	Homo sapiens	58-61
9334260-4	1997	The predicted trypanosome and Leishmania GP63s share a metalloprotease catalytic site motif of HEXXH as well as 19 cysteines and 10 prolines, implying a conservation of enzymatic activity and secondary/tertiary structure.	Proline	132-140	leishmanolysin like peptidase	Homo sapiens	41-45
9334251-4	1997	The MUC3 carboxyl-terminal domain is 617 residues in length, including 511 residues of a non-repetitive mucin-like domain (27% Thr, 22% Ser, and 11% Pro) and a 106-residue Cys-rich domain with homology to the epidermal growth factor (EGF) -like structural motifs found in many proteins.	Proline	149-152	MUC3	Homo sapiens	4-8
9370362-6	1997	Like gastrointestinal trefoil peptides, dopuin has three disulphide bridges, Ala-Pro segments, and many charged residues, but they are differently distributed and dopuin belongs to a separate, apparently novel family.	Proline	81-84	cytochrome c oxidase copper chaperone COX17	Sus scrofa	40-46
9351809-5	1997	Comparison of the bound and unbound Nef structures revealed that a proline-rich motif (Pro-x-x-Pro), which is implicated in SH3 binding, is partially disordered in the absence of the binding partner; this motif only fully adopts a left-handed polyproline type II helix conformation upon complex formation with the Fyn SH3 domain.	Proline	67-74	S100 calcium binding protein B	Homo sapiens	36-39
9351809-5	1997	Comparison of the bound and unbound Nef structures revealed that a proline-rich motif (Pro-x-x-Pro), which is implicated in SH3 binding, is partially disordered in the absence of the binding partner; this motif only fully adopts a left-handed polyproline type II helix conformation upon complex formation with the Fyn SH3 domain.	Proline	67-74	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	314-317
9314539-6	1997	Synaptopodin contains a high amount of proline ( approximately 20%) equally distributed along the protein, thus virtually excluding the formation of any globular domain.	Proline	39-46	synaptopodin	Homo sapiens	0-12
9325278-10	1997	Computer-assisted analysis of the predicted ER1 amino acid sequence revealed two putative nuclear localization signals, four highly acidic regions clustered at the N terminus and a proline-rich region located near the C terminus.	Proline	181-188	mesoderm induction early response 1, transcriptional regulator L homeolog	Xenopus laevis	44-47
9314539-11	1997	From these results and experiments with cultured cells we conclude that synaptopodin represents a novel kind of proline-rich, actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and podocyte foot processes.	Proline	112-119	synaptopodin	Homo sapiens	72-84
9339963-1	1997	Insulin lispro, a recombinant insulin analogue, is identical to human insulin except for the transposition of proline and lysine at positions 28 and 29 in the C-terminus of the B chain.	Proline	110-117	insulin	Homo sapiens	0-7
9349509-2	1997	Efs has characteristic regions important in intracellular signal transduction; these are an SH3 domain, a cluster of putative ligands for SH2 domains and proline-rich sequences with SH3-binding consensus.	Proline	154-161	embryonal Fyn-associated substrate	Homo sapiens	0-3
9351627-3	1997	A two-domain structure with similar amino acid sequences, four intradomain disulfide bonds, and high proline content, which are characteristics common to human and porcine SLPI, was also found in the mouse protein.	Proline	101-108	secretory leukocyte peptidase inhibitor	Homo sapiens	172-176
9372183-0	1997	Introduction of a proline residue into position 31 of the loop of the dimeric 4-alpha-helical protein ROP causes a drastic destabilization.	Proline	18-25	opsin 1, long wave sensitive	Homo sapiens	102-105
9350583-4	1997	The functional properties of the mutation were analyzed using the Xenopus expression system and compared with one mutation affecting the proline-rich sequence of the beta ENaC.	Proline	137-144	sodium channel epithelial 1 subunit beta	Homo sapiens	166-175
9399586-7	1997	In addition, we showed that both S-MBP and L-MBP undergo hydroxylation of lysine and proline residues in collagen-like sequences, and that the hydroxylysine is glycosylated to form glucosylgalactosylhydroxylysine (GluGalHyl) and galactosylhydroxylysine (GalHyl).	Proline	85-92	myelin basic protein	Homo sapiens	35-38
9399586-7	1997	In addition, we showed that both S-MBP and L-MBP undergo hydroxylation of lysine and proline residues in collagen-like sequences, and that the hydroxylysine is glycosylated to form glucosylgalactosylhydroxylysine (GluGalHyl) and galactosylhydroxylysine (GalHyl).	Proline	85-92	myelin basic protein	Homo sapiens	45-48
9349485-3	1997	Sequence analysis reveals significant homology between the vaccinia F8L ORF and the proline repeats of iActA, the protein which initiates actin tail assembly and motility in the bacterial pathogen Listeria ivanovii.	Proline	84-91	Hypothetical protein	Vaccinia virus	68-71
9317120-0	1997	The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.	Proline	35-42	IL2 inducible T cell kinase	Homo sapiens	18-21
9317120-0	1997	The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.	Proline	35-42	IL2 inducible T cell kinase	Homo sapiens	22-25
9317120-0	1997	The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.	Proline	35-42	CD28 molecule	Homo sapiens	121-125
9325160-5	1997	RD1 and RD2 had abundant serine and glycine residues, and proline and serine residues, respectively.	Proline	58-65	phosphodiesterase 6B	Homo sapiens	0-3
9317120-8	1997	Together, our data show that the SH3 domain of Itk binds to a proline-rich motif within the cytoplasmic tail of CD28, and define a mechanism by which CD28 couples to and activates a downstream tyrosine kinase.	Proline	62-69	IL2 inducible T cell kinase	Homo sapiens	47-50
9317120-8	1997	Together, our data show that the SH3 domain of Itk binds to a proline-rich motif within the cytoplasmic tail of CD28, and define a mechanism by which CD28 couples to and activates a downstream tyrosine kinase.	Proline	62-69	CD28 molecule	Homo sapiens	112-116
9317120-8	1997	Together, our data show that the SH3 domain of Itk binds to a proline-rich motif within the cytoplasmic tail of CD28, and define a mechanism by which CD28 couples to and activates a downstream tyrosine kinase.	Proline	62-69	CD28 molecule	Homo sapiens	150-154
9350057-6	1997	A proline to alanine site-directed mutation in the amino terminal SH3 binding motif (SH3bm I) was sufficient to abrogate absorption of AFAP-110 with GST-SH3STC.	Proline	2-9	actin filament associated protein 1	Gallus gallus	135-143
9399433-4	1997	In plants, L-Pro is synthesized from L-glutamic acid (L-Glu) via delta(1)-pyrroline-5-carboxylate (P5C) by two enzymes, P5C synthetase (P5CS) and P5C reductase (P5CR).	Proline	11-16	delta-1-pyrroline-5-carboxylate synthase-like	Nicotiana tabacum	120-134
9399433-4	1997	In plants, L-Pro is synthesized from L-glutamic acid (L-Glu) via delta(1)-pyrroline-5-carboxylate (P5C) by two enzymes, P5C synthetase (P5CS) and P5C reductase (P5CR).	Proline	11-16	delta-1-pyrroline-5-carboxylate synthase-like	Nicotiana tabacum	136-140
9364988-10	1997	These results indicate that the size of the thrombin hydrophobic pocket S2 is sufficient to accept larger residues than proline in the P2 position of Ac-D-Phe-X-boroArg derivatives while this is not the case for other important serine-proteases of the fibrinolysis, coagulation and complement pathways.	Proline	120-127	coagulation factor II, thrombin	Homo sapiens	44-52
9380691-2	1997	In this report we have analyzed signal transduction activities of OB-R containing the fatty mutation [OB-R(fa)], a single amino acid substitution at position 269 (Gln --&gt; Pro) in the OB-R extracellular domain that results in the obese phenotype of the fatty rat.	Proline	174-177	leptin receptor	Rattus norvegicus	66-70
9352462-2	1997	In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM).	Proline	26-29	renin	Rattus norvegicus	124-129
9352462-2	1997	In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM).	Proline	26-29	renin	Homo sapiens	205-210
9352462-3	1997	Peptide Boc-His-Pro-Phe-His-Leu-psi[CH(OH)CH2] Leu-Val-Ile-His-NH2 (XX) was a highly effective inhibitor of rat renin in vivo.	Proline	16-19	renin	Rattus norvegicus	112-117
9315674-5	1997	The third HCF kelch repeat includes a proline residue (P134) that is mutated to serine in hamster tsBN67 cells, resulting in a temperature-sensitive defect in cell proliferation.	Proline	38-45	host cell factor 1	Mesocricetus auratus	10-13
20654329-10	1997	l-proline prevented an initial decline in total and Mu class GST activities in both culture models.	Proline	0-9	hematopoietic prostaglandin D synthase	Rattus norvegicus	61-64
9325160-5	1997	RD1 and RD2 had abundant serine and glycine residues, and proline and serine residues, respectively.	Proline	58-65	peripherin 2	Homo sapiens	8-11
9294229-4	1997	These dyn-1 proteins are highly similar in amino acid sequence, structure, and size to the Drosophila and mammalian dynamins: they contain an N-terminal GTPase, a pleckstrin homology domain, and a C-terminal proline-rich domain.	Proline	208-215	Dynamin	Caenorhabditis elegans	6-11
9380762-5	1997	Analysis of the secondary structure of LCT1 suggests that the protein contains 8-10 transmembrane helices and a hydrophilic amino terminus containing sequences enriched in Pro, Ser, Thr, and Glu (PEST).	Proline	172-175	uncharacterized protein LOC542821	Triticum aestivum	39-43
9333026-5	1997	Alternate splicing of the primary brk transcript generates a distinct mRNA which encodes a truncated protein consisting of an SH3 domain and a novel C-terminal proline rich sequence.	Proline	160-167	protein tyrosine kinase 6	Homo sapiens	34-37
9374203-0	1997	Proline-induced inhibition of glutamate release in hippocampal area CA1.	Proline	0-7	carbonic anhydrase 1	Homo sapiens	68-71
9374203-1	1997	Concentrations of proline typical of human CSF have been shown to potentiate transmission at Schaffer collateral-commissural synapses on CA1 pyramidal cells of the rat hippocampus.	Proline	18-25	colony stimulating factor 2	Homo sapiens	43-46
9374203-1	1997	Concentrations of proline typical of human CSF have been shown to potentiate transmission at Schaffer collateral-commissural synapses on CA1 pyramidal cells of the rat hippocampus.	Proline	18-25	carbonic anhydrase 1	Homo sapiens	137-140
9374203-7	1997	In line with its enhancement of paired-pulse facilitation, 30 microM proline reduced both the K+-evoked release of glutamate and aspartate from CA1 slices and the release of glutamate and aspartate from CA1 synaptosomes evoked by 4-aminopyridine.	Proline	69-76	carbonic anhydrase 1	Homo sapiens	144-147
9374203-7	1997	In line with its enhancement of paired-pulse facilitation, 30 microM proline reduced both the K+-evoked release of glutamate and aspartate from CA1 slices and the release of glutamate and aspartate from CA1 synaptosomes evoked by 4-aminopyridine.	Proline	69-76	carbonic anhydrase 1	Homo sapiens	203-206
9374203-9	1997	Concentrations of proline normally found in human CSF little affect glutamate release.	Proline	18-25	colony stimulating factor 2	Homo sapiens	50-53
9294161-3	1997	Mutational analysis of the transcriptionally active component of NF-E2, p45NF-E2, localizes the critical region for this function to a proline-rich transcriptional activation domain in the NH2-terminal 80 amino acids of the protein.	Proline	135-142	nuclear factor, erythroid 2	Homo sapiens	65-70
9294161-3	1997	Mutational analysis of the transcriptionally active component of NF-E2, p45NF-E2, localizes the critical region for this function to a proline-rich transcriptional activation domain in the NH2-terminal 80 amino acids of the protein.	Proline	135-142	nuclear factor, erythroid 2	Homo sapiens	72-80
9307032-8	1997	There is continuous density for the five residues in the P3, P2, P1, P1" and P2" positions of the peptide (Gly-14f to Pro-18f) at the active site of thrombin, and isolated but well-defined density for Tyr-8f at position P9 in the hydrophobic pocket of thrombin.	Proline	118-121	coagulation factor II, thrombin	Bos taurus	149-157
9307032-8	1997	There is continuous density for the five residues in the P3, P2, P1, P1" and P2" positions of the peptide (Gly-14f to Pro-18f) at the active site of thrombin, and isolated but well-defined density for Tyr-8f at position P9 in the hydrophobic pocket of thrombin.	Proline	118-121	coagulation factor II, thrombin	Bos taurus	252-260
9287362-6	1997	This interaction involved the SH3 region of p50(csk) and a proline-rich region (PPPLPERTPESFVLADM) outside the catalytic region of PTP-PEST.	Proline	59-66	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	131-139
9310476-8	1997	RAFTK coimmunoprecipitated with the cytoskeletal protein paxillin through its C-terminal proline-rich domain in TrHBMEC.	Proline	89-96	protein tyrosine kinase 2 beta	Homo sapiens	0-5
9278444-6	1997	We present evidence that the SH3 and SH2 domains of v-Src bind to proline-rich motifs and a phosphorylated tyrosine residue in the C-terminal tail of Cx43.	Proline	66-73	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	54-57
9278444-10	1997	Mutations in the SH3 and SH2 domains of v-Src, and in the proline-rich region or tyrosine 265 of Cx43, reduced interactions between v-Src and Cx43 in vivo.	Proline	58-65	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	134-137
9278444-10	1997	Mutations in the SH3 and SH2 domains of v-Src, and in the proline-rich region or tyrosine 265 of Cx43, reduced interactions between v-Src and Cx43 in vivo.	Proline	58-65	gap junction protein, alpha 1	Rattus norvegicus	142-146
9298898-4	1997	The conformation of the P+1 pocket is similar to a second proline-directed kinase, CDK2-CyclinA, thus permitting the origin of this specificity to be defined.	Proline	58-65	cyclin dependent kinase 2	Homo sapiens	83-87
9278446-7	1997	A splice variant from the COLQ gene encodes a proline- rich AChE attachment domain without the collagen domain but does not represent the membrane anchor of the brain tetramer.	Proline	46-53	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	26-30
9298898-4	1997	The conformation of the P+1 pocket is similar to a second proline-directed kinase, CDK2-CyclinA, thus permitting the origin of this specificity to be defined.	Proline	58-65	cyclin A2	Homo sapiens	88-95
9278446-7	1997	A splice variant from the COLQ gene encodes a proline- rich AChE attachment domain without the collagen domain but does not represent the membrane anchor of the brain tetramer.	Proline	46-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-64
9272156-3	1997	We observed a novel germline mutation in the hMLH1 gene (His--&gt;Pro at codon 329) in an HNPCC family.	Proline	66-69	mutL homolog 1	Homo sapiens	45-50
9410552-4	1997	The Lilly Laboratories, by inverting the amino acids lysine and proline in positions 28 and 29 in the B chain, have created an insulin (Lispro) which more rapidly dissociates into monomers after injection.	Proline	64-71	insulin	Homo sapiens	127-134
9287978-5	1997	RESULTS: The maximum transport velocity and apparent membrane permeability for proline were 16.1 mumol/ min and 0.07 mumol.min-1.mmol/L-1.	Proline	79-86	ribosomal protein L4	Rattus norvegicus	134-137
9381954-3	1997	Recombinant human cystatin C and E 64 dose dependently inhibited the mobilization of 45Ca and the release of 3H (from [3H]-proline-labelled bones) in mouse calvariae stimulated to resorb by parathyroid hormone (PTH) or 1,25(OH)2-vitamin D3.	Proline	123-130	cystatin C	Homo sapiens	18-28
15991899-1	1997	Insulin lispro (Humalog) is a biosynthetic insulin analogue in which the positions of proline and lysine are reversed in the C-terminal portion of the B chain.	Proline	86-93	insulin	Homo sapiens	0-7
15991899-1	1997	Insulin lispro (Humalog) is a biosynthetic insulin analogue in which the positions of proline and lysine are reversed in the C-terminal portion of the B chain.	Proline	86-93	insulin	Homo sapiens	43-50
9272172-4	1997	C/T base substitution at codon 570 replaced Pro in Tf C1 with Ser in Tf C2.	Proline	44-47	transferrin	Homo sapiens	51-53
9280281-3	1997	Drosophila vinculin is highly homologous in its N- and C-terminal domains both to mammalian and nematode vinculins, and contains internal repeats and proline-rich region typical for vinculins.	Proline	150-157	Vinculin	Drosophila melanogaster	11-19
9261445-3	1997	The incorporation of CyPA into HIV-1 virions is mediated by a specific interaction with a proline-containing, solvent-exposed loop in the capsid (CA) domain of the Gag polyprotein.	Proline	90-97	peptidylprolyl isomerase A	Homo sapiens	21-25
9351242-0	1997	Differential expression of two P5CS genes controlling proline accumulation during salt-stress requires ABA and is regulated by ABA1, ABI1 and AXR2 in Arabidopsis.	Proline	54-61	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	31-35
9351242-0	1997	Differential expression of two P5CS genes controlling proline accumulation during salt-stress requires ABA and is regulated by ABA1, ABI1 and AXR2 in Arabidopsis.	Proline	54-61	Protein phosphatase 2C family protein	Arabidopsis thaliana	133-137
9351242-0	1997	Differential expression of two P5CS genes controlling proline accumulation during salt-stress requires ABA and is regulated by ABA1, ABI1 and AXR2 in Arabidopsis.	Proline	54-61	indole-3-acetic acid 7	Arabidopsis thaliana	142-146
9351242-2	1997	Proline accumulation in response to water stress and salinity is preceded by a rapid increase of the mRNA level of delta 1-pyrroline-5-carboxylate synthase (P5CS) controlling the rate-limiting step of glutamate-derived proline biosynthesis.	Proline	0-7	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	157-161
9351242-2	1997	Proline accumulation in response to water stress and salinity is preceded by a rapid increase of the mRNA level of delta 1-pyrroline-5-carboxylate synthase (P5CS) controlling the rate-limiting step of glutamate-derived proline biosynthesis.	Proline	219-226	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	157-161
9281515-8	1997	Insertion of an additional base next to the frameshift signal placed gag and pro in the same ORF and resulted in predominant formation of Gag-PR and Gag-PR-Pol polyproteins which were not processed following in vitro translation.	Proline	77-80	melanoma antigen	Mus musculus	138-141
9281515-8	1997	Insertion of an additional base next to the frameshift signal placed gag and pro in the same ORF and resulted in predominant formation of Gag-PR and Gag-PR-Pol polyproteins which were not processed following in vitro translation.	Proline	77-80	melanoma antigen	Mus musculus	149-152
9305787-2	1997	The second analog, CB-2, is identical to CB-1 except for the insertion of a Gly-Pro residue pair between Pro-24 and Ala-25.	Proline	80-83	cannabinoid receptor 2	Homo sapiens	19-23
9305787-2	1997	The second analog, CB-2, is identical to CB-1 except for the insertion of a Gly-Pro residue pair between Pro-24 and Ala-25.	Proline	105-108	cannabinoid receptor 2	Homo sapiens	19-23
9265651-2	1997	This resulted in the identification of proline, serine, threonine phosphatase interacting protein (PSTPIP), a novel member of the actin- associated protein family that is homologous to Schizosaccharomyces pombe CDC15p, a phosphorylated protein involved with the assembly of the actin ring in the cytokinetic cleavage furrow.	Proline	39-46	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	99-105
9265651-3	1997	The binding of PTP HSCF to PSTPIP was induced by a novel interaction between the putative coiled-coil region of PSTPIP and the COOH-terminal, proline-rich region of the phosphatase.	Proline	142-149	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	27-33
9265651-3	1997	The binding of PTP HSCF to PSTPIP was induced by a novel interaction between the putative coiled-coil region of PSTPIP and the COOH-terminal, proline-rich region of the phosphatase.	Proline	142-149	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	112-118
9265651-5	1997	This dominant-negative effect is dependent upon the inclusion of the COOH-terminal, proline-rich PSTPIP-binding region of the phosphatase.	Proline	84-91	proline-serine-threonine phosphatase interacting protein 1	Homo sapiens	97-103
9256434-4	1997	Accordingly, these two proteins have been called proline-rich Gla proteins (PRGP1 and PRGP2).	Proline	49-56	proline rich and Gla domain 1	Homo sapiens	76-81
9256434-4	1997	Accordingly, these two proteins have been called proline-rich Gla proteins (PRGP1 and PRGP2).	Proline	49-56	proline rich and Gla domain 2	Homo sapiens	86-91
9266755-13	1997	The extra 93 base pairs encode 31 amino acids corresponding to a proline-rich region located between saposin C and saposin D in the mouse prosaposin molecule.	Proline	65-72	prosaposin	Mus musculus	138-148
9315092-5	1997	The deduced amino acid sequence of the full length mouse Shd cDNA contains an amino-terminal proline-rich region, and a carboxyterminal SH2 domain.	Proline	93-100	src homology 2 domain-containing transforming protein D	Mus musculus	57-60
9446323-5	1997	The p53 Arg/Pro polymorphism study revealed the elevated frequency of Arg allele in lung and stomach cancer groups.	Proline	12-15	tumor protein p53	Homo sapiens	4-7
9305772-2	1997	The Finb protein consists of 1656 amino acids, containing 15 C2H2-type zinc fingers and three proline-rich regions.	Proline	94-101	ras responsive element binding protein 1	Homo sapiens	4-8
9285683-2	1997	We have identified a high affinity interaction between the SH3 domain of p130cas and a proline-rich sequence (P335PPKPPR) within the C-terminal segment of PTP-PEST.	Proline	87-94	BCAR1 scaffold protein, Cas family member	Homo sapiens	73-80
9285683-2	1997	We have identified a high affinity interaction between the SH3 domain of p130cas and a proline-rich sequence (P335PPKPPR) within the C-terminal segment of PTP-PEST.	Proline	87-94	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	155-163
9285683-3	1997	Mutation of proline 337 within this sequence to alanine significantly impairs the ability of PTP-PEST to recognise tyrosine phosphorylated p130cas as a substrate, without qualitatively affecting the selectivity of the interaction.	Proline	12-19	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	93-101
9285683-3	1997	Mutation of proline 337 within this sequence to alanine significantly impairs the ability of PTP-PEST to recognise tyrosine phosphorylated p130cas as a substrate, without qualitatively affecting the selectivity of the interaction.	Proline	12-19	BCAR1 scaffold protein, Cas family member	Homo sapiens	139-146
9288906-3	1997	This Nef/actin complex was present in human B and T lymphocytes but not in insect cells and was dependent on the N-terminal myristoylation of Nef, whereas the SH3-binding proline motif of Nef was not involved.	Proline	171-178	S100 calcium binding protein B	Homo sapiens	5-8
9235982-5	1997	Our study suggests that the binding of proline-rich peptides, or corresponding cellular interaction partners, to Lyn SH3 domain suppresses the Lyn-mediated phosphorylatation of FcepsilonRI and calcium signaling.	Proline	39-46	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	113-116
9235982-5	1997	Our study suggests that the binding of proline-rich peptides, or corresponding cellular interaction partners, to Lyn SH3 domain suppresses the Lyn-mediated phosphorylatation of FcepsilonRI and calcium signaling.	Proline	39-46	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	143-146
9235982-5	1997	Our study suggests that the binding of proline-rich peptides, or corresponding cellular interaction partners, to Lyn SH3 domain suppresses the Lyn-mediated phosphorylatation of FcepsilonRI and calcium signaling.	Proline	39-46	Fc epsilon receptor Ia	Homo sapiens	177-188
9288906-3	1997	This Nef/actin complex was present in human B and T lymphocytes but not in insect cells and was dependent on the N-terminal myristoylation of Nef, whereas the SH3-binding proline motif of Nef was not involved.	Proline	171-178	S100 calcium binding protein B	Homo sapiens	142-145
9288906-3	1997	This Nef/actin complex was present in human B and T lymphocytes but not in insect cells and was dependent on the N-terminal myristoylation of Nef, whereas the SH3-binding proline motif of Nef was not involved.	Proline	171-178	S100 calcium binding protein B	Homo sapiens	142-145
9416003-3	1997	The specificity or regulation of in vivo signaling to the mammalian MEKs (MEK1 and MEK2) was recently reported also to involve the differential phosphorylation of a proline-rich peptide located between the MEK kinase-subdomains IX and X.	Proline	165-172	mitogen-activated protein kinase kinase 1	Homo sapiens	74-78
9416003-3	1997	The specificity or regulation of in vivo signaling to the mammalian MEKs (MEK1 and MEK2) was recently reported also to involve the differential phosphorylation of a proline-rich peptide located between the MEK kinase-subdomains IX and X.	Proline	165-172	mitogen-activated protein kinase kinase 2	Homo sapiens	83-87
9416003-4	1997	Here we report the purification and characterization of an auto-activating protein kinase from bovine brain that phosphorylates serine-298 of the MEK1 and MEK2 proline-rich insert peptides.	Proline	160-167	mitogen-activated protein kinase kinase 2	Homo sapiens	155-159
9416005-6	1997	The effect of the nitrogen source on UGA4 permease was studied measuring ALA and GABA uptake rates in cells from media with ammonium, proline and urea as nitrogen sources.	Proline	134-141	Uga4p	Saccharomyces cerevisiae S288C	37-41
9235918-7	1997	We also observed that the calpain-mediated digestion in vitro is dependent on the presence of a sequence containing a proline-rich region and multiple tyrosine residues that are phosphorylated by pp60(c-)src.	Proline	118-125	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	196-207
9279753-2	1997	One such point mutation, resulting in the substitution of proline by arginine in a critical region of the linker region between the first and second immunoglobulin-like domains, is associated with highly specific phenotypic consequences in that mutation at this point in FGFR1 results in Pfeiffer syndrome and analogous mutation in FGFR2 results in Apert syndrome.	Proline	58-65	fibroblast growth factor receptor 1	Homo sapiens	271-276
9378721-0	1997	Role of the pyrrolidine ring of proline in determining the substrate specificity of cdc2 kinase or cdk5.	Proline	32-39	cyclin dependent kinase 5	Homo sapiens	99-103
9378721-3	1997	For cdk5, these substitutions led to parallel effects on the K(m) value to those found for cdc2 kinase; cdk5 recognized the peptides with a proline specificity similar to that for cdc2 kinase.	Proline	140-147	cyclin dependent kinase 5	Homo sapiens	4-8
9378721-3	1997	For cdk5, these substitutions led to parallel effects on the K(m) value to those found for cdc2 kinase; cdk5 recognized the peptides with a proline specificity similar to that for cdc2 kinase.	Proline	140-147	cyclin dependent kinase 5	Homo sapiens	104-108
9378721-4	1997	These results suggest that the pyrrolidine ring of proline is important for substrate recognition by cdc2 kinase or cdk5.	Proline	51-58	cyclin dependent kinase 5	Homo sapiens	116-120
9378721-6	1997	The results obtained here also suggest that the pyrrolidine ring of proline is required to maintain a high V(max) value for cdc2 kinase or especially for cdk5.	Proline	68-75	cyclin dependent kinase 5	Homo sapiens	154-158
9233621-4	1997	Analysis of these chimeric Gal4-STAT6 proteins demonstrates that a 140-amino-acid proline-rich region of the carboxyl terminus of STAT6 contains a region that activates transcription.	Proline	82-89	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	27-31
9296389-6	1997	Targeting of the proline rich domain of zyxin to the plasma membrane disrupts the actin cytoskeleton and cell shape in a manner similar to that which occurs with membrane-targeted ActA sequences.	Proline	17-24	zyxin	Homo sapiens	40-45
9279753-2	1997	One such point mutation, resulting in the substitution of proline by arginine in a critical region of the linker region between the first and second immunoglobulin-like domains, is associated with highly specific phenotypic consequences in that mutation at this point in FGFR1 results in Pfeiffer syndrome and analogous mutation in FGFR2 results in Apert syndrome.	Proline	58-65	fibroblast growth factor receptor 2	Homo sapiens	332-337
9273895-4	1997	Peptide Boc-His-Pro-Phe-His-Sta-Val-Ile-His-NH2 (VI) is the best inhibitor of human renin containing Sta at position 10.	Proline	16-19	renin	Homo sapiens	84-89
9273895-6	1997	Peptides Boc-His-Pro-Phe-His-Ads-Val-Ile-His-NH2 (VII) having Ads at position 10 had an IC50 of 12 nM against rat renin.	Proline	17-20	renin	Rattus norvegicus	114-119
9234682-5	1997	This functional selection strategy was very effective, leading to strong dominant negative CIITA mutants in which the N-terminal acidic and proline/serine/threonine-rich regions were completely deleted.	Proline	140-147	class II major histocompatibility complex transactivator	Homo sapiens	91-96
9259313-10	1997	Our model suggests that the p85 subunit of PI 3-kinase is constitutively associated with cbl through binding of the p85 SH3 domain to a proline-rich sequence in cbl.	Proline	136-143	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	28-31
9234729-3	1997	The polypeptide of galectin-3 has two domains, a carboxyl-terminal CRD fused onto a proline- and glycine-rich amino-terminal domain.	Proline	84-91	galectin 3	Homo sapiens	19-29
9259313-10	1997	Our model suggests that the p85 subunit of PI 3-kinase is constitutively associated with cbl through binding of the p85 SH3 domain to a proline-rich sequence in cbl.	Proline	136-143	Cbl proto-oncogene	Homo sapiens	89-92
9259313-10	1997	Our model suggests that the p85 subunit of PI 3-kinase is constitutively associated with cbl through binding of the p85 SH3 domain to a proline-rich sequence in cbl.	Proline	136-143	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	116-119
9271346-11	1997	The change in desensitization may be determined by proline/serine-rich segments and/or phosphorylation motifs that are removed from the tail region in formation of the P2X2(b) subunit.	Proline	51-58	purinergic receptor P2X 2	Rattus norvegicus	168-172
9259313-10	1997	Our model suggests that the p85 subunit of PI 3-kinase is constitutively associated with cbl through binding of the p85 SH3 domain to a proline-rich sequence in cbl.	Proline	136-143	Cbl proto-oncogene	Homo sapiens	161-164
9266709-3	1997	Replacement of the P2" residue Pro by Val in Abz-TSVIRRPQ-EDDnp gave a far less specific substrate that was rapidly hydrolysed by all five rat kallikreins and human kallikrein hK1.	Proline	31-34	keratin 1	Homo sapiens	176-179
9286116-10	1997	However, as an oleosin-beta-glucuronidase translational fusion, the proline knot variant failed to target to oil bodies in both transient embryo expression and in stably transformed seeds.	Proline	68-75	glucuronidase beta	Canis lupus familiaris	23-41
9286116-11	1997	Fractionation of transgenic embryos expressing oleosin-beta-glucuronidase fusions showed that the proline knot variant accumulated in the ER to similar levels compared with the native form.	Proline	98-105	glucuronidase beta	Canis lupus familiaris	55-73
9271198-2	1997	LTBP-4 consists of 20 EG modules, 17 of them with a consensus sequence for calcium binding, 4 TB modules with 8 cysteines and several proline-rich regions.	Proline	134-141	latent transforming growth factor beta binding protein 4	Homo sapiens	0-6
9464530-9	1997	NCCRP-1 is proline rich (9%), has two glycosylation sites and 18% of all amino acids are potential phosphorylation sites (serine, threonine, tyrosine).	Proline	11-18	NCCRP1, F-box associated domain containing	Homo sapiens	0-7
9464530-15	1997	An algorithm predicting the membrane conformation of NCCRP-1 suggests one extracellular proline-rich domain, a transmembrane portion of 15 18 aa and a cytoplasmic tail composed of a high frequency of phosphorylation sites.	Proline	88-95	NCCRP1, F-box associated domain containing	Homo sapiens	53-60
9272869-4	1997	Multiple alignment for aa sequences of RpII LS from various species revealed that this Pro residue was highly conserved throughout the eukaryotes.	Proline	87-90	DNA-directed RNA polymerase II subunit RPB1	Cricetulus griseus	39-46
9272869-5	1997	Considering the differences in physico-chemical properties between Pro and Ser residues, the Pro--&gt;Ser substitution may alter the RpII LS structure.	Proline	67-70	DNA-directed RNA polymerase II subunit RPB1	Cricetulus griseus	133-140
9272871-5	1997	mSTI1 has ten potential TPR motifs, a putative nuclear localization signal (NLS), six potential phosphorylation sites for casein kinase II and a central proline-rich region.	Proline	153-160	stress-induced phosphoprotein 1	Mus musculus	0-5
9218412-6	1997	Mutagenesis of the Nef proline-rich motif essential for SH3 binding completely blocked complex formation, kinase activation, and transformation, indicating that the Nef SH3-binding function is required for its effects on Hck.	Proline	23-30	S100 calcium binding protein B	Homo sapiens	19-22
9218412-6	1997	Mutagenesis of the Nef proline-rich motif essential for SH3 binding completely blocked complex formation, kinase activation, and transformation, indicating that the Nef SH3-binding function is required for its effects on Hck.	Proline	23-30	S100 calcium binding protein B	Homo sapiens	165-168
9218412-6	1997	Mutagenesis of the Nef proline-rich motif essential for SH3 binding completely blocked complex formation, kinase activation, and transformation, indicating that the Nef SH3-binding function is required for its effects on Hck.	Proline	23-30	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	221-224
9252026-6	1997	Proline enhanced Schaffer collateral-commissural synaptic transmission even when the connections between areas CA1 and CA3 had been interrupted.	Proline	0-7	carbonic anhydrase 1	Homo sapiens	111-114
9211889-5	1997	We found that the membrane proximal proline-rich domain and adjacent 16 residues are essential for both hGM-CSF-dependent cell proliferation and differentiation.	Proline	36-43	colony stimulating factor 2	Homo sapiens	104-111
9207119-3	1997	In this study, we report the cDNA cloning of human and murine FYB and show that it is restricted in expression to T cells and myeloid cells and possesses an overall unique hydrophilic sequence with several tyrosine-based motifs, proline-based type I and type II SH3 domain binding motifs, several putative lysine/glutamic acid-rich nuclear localization motifs, and a SH3-like domain.	Proline	229-236	FYN binding protein	Mus musculus	62-65
9252026-6	1997	Proline enhanced Schaffer collateral-commissural synaptic transmission even when the connections between areas CA1 and CA3 had been interrupted.	Proline	0-7	carbonic anhydrase 3	Homo sapiens	119-122
9296364-1	1997	Dipeptidyl peptidase IV (DPP IV, EC 3.4.14.5), also known as CD26, is a membrane-bound serine protease that cleaves off aminoterminal dipeptides from peptides with a penultimate proline (or, at a much slower rate, a penultimate alanine).	Proline	178-185	dipeptidyl peptidase 4	Oryctolagus cuniculus	0-23
9365789-6	1997	This peptide is related to xenopsin, neurotensin and neuromedin N which are bioactive peptides derived from larger precursors via proteolytic cleavage by cathepsin E at processing sites determined by conserved C-terminal sequences, i.e. proline/valine-X-X-hydrophobic amino acid.	Proline	237-244	neurotensin	Homo sapiens	37-48
9365789-6	1997	This peptide is related to xenopsin, neurotensin and neuromedin N which are bioactive peptides derived from larger precursors via proteolytic cleavage by cathepsin E at processing sites determined by conserved C-terminal sequences, i.e. proline/valine-X-X-hydrophobic amino acid.	Proline	237-244	cathepsin E	Homo sapiens	154-165
9296364-1	1997	Dipeptidyl peptidase IV (DPP IV, EC 3.4.14.5), also known as CD26, is a membrane-bound serine protease that cleaves off aminoterminal dipeptides from peptides with a penultimate proline (or, at a much slower rate, a penultimate alanine).	Proline	178-185	dipeptidyl peptidase 4	Oryctolagus cuniculus	25-31
9218844-8	1997	Extended CDR3s more than nine residues in length were found in 18% of the sequences, and in 71% of cases this was due to insertion of an extra proline residue.	Proline	143-150	CDR3	Homo sapiens	9-13
9233561-7	1997	The 467(Pro-->Arg) substitution responsible for G6PD Neapolis is discussed in the light of the current 3D model of human G6PD and in comparison with other natural mutations which occur in the proximity of residue 467.	Proline	8-11	glucose-6-phosphate dehydrogenase	Homo sapiens	48-52
9233561-7	1997	The 467(Pro-->Arg) substitution responsible for G6PD Neapolis is discussed in the light of the current 3D model of human G6PD and in comparison with other natural mutations which occur in the proximity of residue 467.	Proline	8-11	glucose-6-phosphate dehydrogenase	Homo sapiens	121-125
9253509-2	1997	Codon 72 of the p53 gene is highly polymorphic with a reported arginine/proline allelotype frequency of 0.65/0.35 for Caucasians and a reversal of this ratio in African-Americans.	Proline	72-79	tumor protein p53	Homo sapiens	16-19
9299869-15	1997	The fact that BCR-ABL contains tyrosine residues, an SH2 domain, an SH3 domain, and proline-rich sequences raises the possibility of multiple protein-protein interactions.	Proline	84-91	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	14-21
9272717-0	1997	A T &gt; C transition causing a Leu &gt; Pro substitution in a conserved region of the arylsulfatase A gene in a late infantile metachromatic leukodystrophy patient.	Proline	41-44	arylsulfatase A	Homo sapiens	87-102
9248708-2	1997	For some short acting insulin analogues, in particular for [Lys(B28),Pro(B29)]-human insulin, preclinical and clinical trials have been performed.	Proline	69-72	insulin	Homo sapiens	22-29
9248708-2	1997	For some short acting insulin analogues, in particular for [Lys(B28),Pro(B29)]-human insulin, preclinical and clinical trials have been performed.	Proline	69-72	insulin	Homo sapiens	85-92
9233798-6	1997	These tyrosine residues are followed by proline at the + 3 position, consistent with the binding specificity of RasGAP SH2 domains determined using a degenerate phosphopeptide library.	Proline	40-47	RAS p21 protein activator 1	Mus musculus	112-118
9202310-2	1997	Tau from normal brain and especially from foetal brain is also phosphorylated on some of the sites phosphorylated in PHFs, mainly at serines or threonines followed by prolines.	Proline	167-175	microtubule associated protein tau	Homo sapiens	0-3
9199449-4	1997	This soluble rDBP product contained the cysteine-rich ligand domain and most of the contiguous proline-rich hydrophilic region.	Proline	95-102	D-box binding PAR bZIP transcription factor	Rattus norvegicus	13-17
9204966-0	1997	A novel threonine --> proline mutation at the end of 2B rod domain in the keratin 2e chain in ichthyosis bullosa of Siemens.	Proline	22-29	keratin 2	Homo sapiens	74-84
9204966-1	1997	We report a novel mutation in a case of ichthyosis bullosa of Siemens that results in a threonine --> proline substitution in a novel location, codon 485 in a highly conserved residue position of the IATYRKLLEGE consensus motif at the end of the 2B rod domain segment of the keratin 2e chain.	Proline	102-109	keratin 2	Homo sapiens	275-285
9204959-8	1997	The mutation leads to the substitution of serine for the highly conserved proline 315 in the FALDH protein, and expression studies confirm that it destroys enzymatic activity.	Proline	74-81	aldehyde dehydrogenase 3 family member A2	Homo sapiens	93-98
9202310-3	1997	A number of protein kinases can phosphorylate tau in vitro; those that require or accept prolines include GSK3 and members of the mitogen-activated protein (MAP) kinase family, ERK1, ERK2, and SAP kinase-beta/JNK.	Proline	89-97	microtubule associated protein tau	Homo sapiens	46-49
9202310-3	1997	A number of protein kinases can phosphorylate tau in vitro; those that require or accept prolines include GSK3 and members of the mitogen-activated protein (MAP) kinase family, ERK1, ERK2, and SAP kinase-beta/JNK.	Proline	89-97	mitogen-activated protein kinase 3	Homo sapiens	177-181
9202310-3	1997	A number of protein kinases can phosphorylate tau in vitro; those that require or accept prolines include GSK3 and members of the mitogen-activated protein (MAP) kinase family, ERK1, ERK2, and SAP kinase-beta/JNK.	Proline	89-97	mitogen-activated protein kinase 1	Homo sapiens	183-187
9202310-3	1997	A number of protein kinases can phosphorylate tau in vitro; those that require or accept prolines include GSK3 and members of the mitogen-activated protein (MAP) kinase family, ERK1, ERK2, and SAP kinase-beta/JNK.	Proline	89-97	mitogen-activated protein kinase 8	Homo sapiens	193-212
9256341-2	1997	We demonstrated previously that individuals affected with an autosomal dominant disorder of skull morphogenesis (craniosynostosis, Boston type) bear a mutated form of Msx2 in which a histidine is substituted for a highly conserved proline in position 7 of the N-terminal arm of the homeodomain (p148h).	Proline	231-238	msh homeobox 2	Rattus norvegicus	167-171
9199323-2	1997	It also contains a tyrosine residue and a proline-rich sequence near the C terminus, which are the binding sites for the SH2 and SH3 domains of Src kinase, respectively.	Proline	42-49	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	144-147
9195982-10	1997	The structural organization of IIM is similar to that of MUC2, containing a 25-amino acid signal leading sequence and two threonine/proline/alanine-rich tandem repeat domains flanked by cysteine-rich sequences.	Proline	132-139	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	57-61
9171106-4	1997	Within the transactivation domain, two discrete proline-rich regions were required for rescue of beta-globin expression.	Proline	48-55	hemoglobin beta chain complex	Mus musculus	97-108
9219911-8	1997	Addition of proline to plasma samples before ultracentrifugation (final concentration: 0.1 M) substantially reduced the amount of Lp(a) in UTC-TRL.	Proline	12-19	lipoprotein(a)	Homo sapiens	130-135
9188447-1	1997	Kinetic measurements on a fluorescent peptide analog of the p17/p24 cleavage site of the Gag polyprotein demonstrate the conformational selectivity of human immunodeficiency virus, type 1 protease for the trans conformation of the Tyr-Pro bond.	Proline	235-238	Pr55(Gag)	Human immunodeficiency virus 1	89-92
9223641-7	1997	These studies reveal that the active site of CypA, which can catalyze the isomerization of proline residues in vitro, also functions as a sequence-specific, protein-binding motif in HIV-1 replication.	Proline	91-98	peptidylprolyl isomerase A	Homo sapiens	45-49
9192750-4	1997	In the RA-resistant subclone, R4, we find an absence of ligand binding of PML-RAR alpha associated with a point mutation changing a leucine to proline in the ligand-binding domain of the fusion PML-RAR alpha protein.	Proline	143-150	PML nuclear body scaffold	Homo sapiens	194-197
9182529-2	1997	To identify new SH3-containing proteins, we performed a two-hybrid screen with a proline-rich region of human SOS-1.	Proline	81-88	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	110-115
9171106-9	1997	The requirement for discrete proline-rich sequences within the transactivation domain suggests that globin gene expression in MEL cells depends on specific interactions between NF-E2 and downstream effector molecules.	Proline	29-36	nuclear factor, erythroid derived 2	Mus musculus	177-182
9182529-8	1997	On a biosensor surface, the BRAMP2/dynamin interaction appeared to be direct and partly dependent on a proline-rich sequence of dynamin.	Proline	103-110	bridging integrator 1	Mus musculus	28-34
9227416-2	1997	We have recently identified the ubiquitin-protein ligase Nedd4 as an interacting protein with ENaC and demonstrated that Nedd4 binds by its WW domains to the proline-rich PY motifs of ENaC.	Proline	158-165	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	57-62
9200606-4	1997	Pin1 displays a preference for an acidic residue N-terminal to the isomerized proline bond due to interaction of this acidic side chain with a basic cluster.	Proline	78-85	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
9190895-6	1997	The oncogenic activity of AKT2 was diminished by truncation of a 70-amino acid proline-rich region at the carboxyl-terminus.	Proline	79-86	thymoma viral proto-oncogene 2	Mus musculus	26-30
9227416-2	1997	We have recently identified the ubiquitin-protein ligase Nedd4 as an interacting protein with ENaC and demonstrated that Nedd4 binds by its WW domains to the proline-rich PY motifs of ENaC.	Proline	158-165	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	121-126
9227416-2	1997	We have recently identified the ubiquitin-protein ligase Nedd4 as an interacting protein with ENaC and demonstrated that Nedd4 binds by its WW domains to the proline-rich PY motifs of ENaC.	Proline	158-165	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	184-188
9182712-3	1997	Thimet oligopeptidase was able to hydrolyse, with similar catalytic efficiency, peptide bonds having hydrophobic or hydrophilic amino acids as well as proline in the P1 position of peptides, ranging from a minimum of six to a maximum of approximately thirteen amino acid residues.	Proline	151-158	thimet oligopeptidase 1	Rattus norvegicus	0-21
9192847-6	1997	The longer isoform, called B4, differs from the ABCDEF isoform of ZNF162 by the insertion, at position 2137, of 383 nucleotides leading to a different, proline-rich COOH terminus.	Proline	152-159	splicing factor 1	Homo sapiens	66-72
9212169-8	1997	The predicted MZFM protein contains diverse functional domains, i.e., a nuclear localization signal, a metal binding motif, a glutamine/proline stretch, proline-clusters, a CGA-motif, and a QUA1-KH-QUA2 region, thus indicating multiple functions of MZFM.	Proline	136-143	splicing factor 1	Mus musculus	14-18
9212169-8	1997	The predicted MZFM protein contains diverse functional domains, i.e., a nuclear localization signal, a metal binding motif, a glutamine/proline stretch, proline-clusters, a CGA-motif, and a QUA1-KH-QUA2 region, thus indicating multiple functions of MZFM.	Proline	153-160	splicing factor 1	Mus musculus	14-18
9182571-9	1997	Analyses of AP-2 mutants revealed a requirement for the DNA binding/dimerization domain and the amino-terminal proline-rich and acid-rich transactivation domains for stimulation of the CGbeta promoter.	Proline	111-118	transcription factor AP-2 alpha	Homo sapiens	12-16
9376661-3	1997	BCR-ABL contains tyrosine residues, an SH2 domain, an SH3 domain, and proline-rich sequences.	Proline	70-77	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-7
9187140-3	1997	hindsight encodes a large nuclear protein of 1920 amino acids that contains fourteen C2H2-type zinc fingers, and glutamine-rich and proline-rich domains, suggesting that it functions as a transcription factor.	Proline	132-139	pebbled	Drosophila melanogaster	0-9
9159166-7	1997	Disruption of the Jak1-binding proline-rich Box1 region of IL-4Ralpha abolished signaling by this chimeric receptor.	Proline	31-38	Janus kinase 1	Homo sapiens	18-22
9166584-2	1997	A point mutation (T to C) that results in substitution of proline for serine in a putative eighth transmembrane domain of the ATP7A was identified.	Proline	58-65	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	126-131
9230894-7	1997	This repression requires the Cyc8 and Tup1 proteins and is dependent on a C-terminal region comprising several conserved leucine-proline repeats.	Proline	129-136	transcription regulator CYC8	Saccharomyces cerevisiae S288C	29-33
9230894-7	1997	This repression requires the Cyc8 and Tup1 proteins and is dependent on a C-terminal region comprising several conserved leucine-proline repeats.	Proline	129-136	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	38-42
9189858-6	1997	Furthermore, to reveal the detailed binding sites in the interaction, the same inhibition assays were performed using the following substances composing the IgA1 hinge glycopeptide: galactose (Gal), N-acetyl-galactosamine (GalNAc), Gal beta 1-3GalNAc, sialic acid, tetrapeptide PTPS, and synthesized hinge proline-rich peptide PVPSTPPTPSPSTPPTPSPS (sHP).	Proline	306-313	immunoglobulin heavy constant alpha 1	Homo sapiens	157-161
9151736-1	1997	A nonconservative leucine to proline mutation in peripheral myelin protein 22 (PMP22) causes the Trembler-J (TrJ) neuropathy in mice and humans.	Proline	29-36	peripheral myelin protein 22	Mus musculus	49-77
9151736-1	1997	A nonconservative leucine to proline mutation in peripheral myelin protein 22 (PMP22) causes the Trembler-J (TrJ) neuropathy in mice and humans.	Proline	29-36	peripheral myelin protein 22	Mus musculus	79-84
9174356-0	1997	Structure-function studies of the brain-type glucose transporter, GLUT3: alanine-scanning mutagenesis of putative transmembrane helix VIII and an investigation of the role of proline residues in transport catalysis.	Proline	175-182	solute carrier family 2 member 3	Homo sapiens	66-71
9174356-7	1997	We have also examined the role of proline residues in transport catalysis mediated by GLUT3.	Proline	34-41	solute carrier family 2 member 3	Homo sapiens	86-91
9159166-7	1997	Disruption of the Jak1-binding proline-rich Box1 region of IL-4Ralpha abolished signaling by this chimeric receptor.	Proline	31-38	interleukin 4 receptor	Homo sapiens	59-69
9153198-5	1997	XMMP lacks a proline-rich linker peptide, or hinge region, typically found in other MMPs between the catalytic domain and carboxyl-terminal "hemopexin/vitronectin-like" domain.	Proline	13-20	matrix metallopeptidase 21 L homeolog	Xenopus laevis	0-4
9188861-0	1997	BCL-6 is phosphorylated at multiple sites in its serine- and proline-clustered region by mitogen-activated protein kinase (MAPK) in vivo.	Proline	61-68	BCL6 transcription repressor	Homo sapiens	0-5
9151708-4	1997	The SRG3 protein contains an acidic NH2 terminus, a myb-like DNA binding domain, a leucine-zipper motif, and a proline- and glutamine-rich region at its COOH terminus.	Proline	111-118	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	Mus musculus	4-8
9210596-7	1997	Like human Tob, mouse Tob is characterized by the presence of a sequence rich in proline and glutamine which is often present in the sequence of transcription factors.	Proline	81-88	transducer of ERBB2, 1	Homo sapiens	11-14
9210596-7	1997	Like human Tob, mouse Tob is characterized by the presence of a sequence rich in proline and glutamine which is often present in the sequence of transcription factors.	Proline	81-88	transducer of ErbB-2.1	Mus musculus	22-25
9148966-0	1997	The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence.	Proline	40-47	amphiphysin	Homo sapiens	18-29
9148966-2	1997	We show here that the SH3 domain of amphiphysin, but not a mutant SH3 domain, bound with high affinity to a single site in the long proline-rich region of human dynamin I, that this site was distinct from the binding sites for other SH3 domains, and that the mutation of two adjacent amino acids in dynamin I was sufficient to abolish binding.	Proline	132-139	amphiphysin	Homo sapiens	36-47
9148890-8	1997	A mutant JEM1p carrying a mutation in the highly conserved His-Pro-Asp sequence in the J-domain could not complement either temperature-sensitive growth of the Deltajem1 Deltascj1 double mutant or defects in karyogamy of the Deltajem1 mutant.	Proline	63-66	Jem1p	Saccharomyces cerevisiae S288C	9-14
9202403-0	1997	The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor.	Proline	9-16	Janus kinase 2	Homo sapiens	60-64
9177280-3	1997	Nucleotide sequencing of the PCR-amplified exons from the genomic DNA of this patient revealed a single point mutation CTG (leucine) CCG (proline) at codon 461 in exon 8 of CYP11B2, which is involved in the putative heme binding site of steroid 18-hydroxylase (P450(C18)).	Proline	138-145	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	173-180
9202403-0	1997	The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor.	Proline	9-16	prolactin receptor	Homo sapiens	98-116
9202403-5	1997	Our data suggest that the Box 1 region of the PRL receptor and particularly the last proline is critical for JAK2 association and subsequent activation.	Proline	85-92	prolactin	Homo sapiens	46-49
9202403-5	1997	Our data suggest that the Box 1 region of the PRL receptor and particularly the last proline is critical for JAK2 association and subsequent activation.	Proline	85-92	Janus kinase 2	Homo sapiens	109-113
9139709-2	1997	In the primary sequence of the constitutive form, HO-2, there are three potential heme binding sites: two heme regulatory motifs (HRMs) with the absolutely conserved Cys-Pro pair, and a conserved 24-residue heme catalytic pocket with a histidine residue, His151 in rat HO-2.	Proline	170-173	heme oxygenase 2	Rattus norvegicus	50-54
9139722-9	1997	Inactivation of PAI-1-P6(Val --&gt; Pro) resulted in a total conversion of the active form into the latent form and in a partial conversion of the substrate form into the latent form.	Proline	36-39	serpin family E member 1	Homo sapiens	16-21
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	21-24	serpin family E member 1	Homo sapiens	0-5
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	21-24	plasminogen activator, tissue type	Homo sapiens	66-70
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	21-24	plasminogen activator, tissue type	Homo sapiens	138-142
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	21-24	plasminogen activator, urokinase	Homo sapiens	147-151
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	21-24	serpin family E member 1	Homo sapiens	168-173
9139722-10	1997	The active forms of both PAI-1-P10(Ser --&gt; Pro) and PAI-1-P18(Asn --&gt; Pro) are also labile but, in contrast to the active form of wtPAI-1, convert into substrate forms.	Proline	46-49	serpin family E member 1	Homo sapiens	25-30
9139722-10	1997	The active forms of both PAI-1-P10(Ser --&gt; Pro) and PAI-1-P18(Asn --&gt; Pro) are also labile but, in contrast to the active form of wtPAI-1, convert into substrate forms.	Proline	46-49	S100 calcium binding protein A10	Homo sapiens	31-34
9144171-6	1997	The amino-terminal domain of RIN1 contains a proline-rich sequence similar to consensus Src homology 3 (SH3) binding regions.	Proline	45-52	Ras and Rab interactor 1	Homo sapiens	29-33
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	21-24	S100 calcium binding protein A10	Homo sapiens	174-177
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	21-24	S100 calcium binding protein A10	Homo sapiens	197-200
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	21-24	plasminogen activator, urokinase	Homo sapiens	232-236
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	21-24	plasminogen activator, tissue type	Homo sapiens	138-142
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	21-24	serpin family E member 1	Homo sapiens	259-268
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	21-24	H3 histone pseudogene 12	Homo sapiens	265-268
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	21-24	plasminogen activator, urokinase	Homo sapiens	232-236
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	190-193	serpin family E member 1	Homo sapiens	0-5
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	190-193	plasminogen activator, tissue type	Homo sapiens	66-70
9250352-6	1997	The examination of the ALDH3 locus of three additional SLS patients showed that two are heterozygous with C-->G at nt 985 (Pro-->Ala at protein position 329).	Proline	123-126	aldehyde dehydrogenase 3 family member A1	Homo sapiens	23-28
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	190-193	serpin family E member 1	Homo sapiens	0-5
9139722-7	1997	PAI-1-P6 (Val --&gt; Pro at P6) revealed a target specificity for t-PA (39 +/- 7% versus 3 +/- 2% of the theoretical maximal value toward t-PA and u-PA, respectively), PAI-1-P10 (Ser --&gt; Pro at P10) was 4-fold more active toward u-PA than toward t-PA, and PAI-1-P18 (Asn --&gt; Pro at P18) exhibited inhibitory properties exclusively toward u-PA (41 +/- 10%).	Proline	190-193	plasminogen activator, tissue type	Homo sapiens	66-70
9174058-7	1997	Domain analysis studies indicate that both SH3 domains of GRB2 bind to the proline rich region of cbl in quiescent BaF3 cells, whereas GRB2 SH2 domain interacts with a non-contiguous sequence of cbl in transformed cells.	Proline	75-82	growth factor receptor bound protein 2	Mus musculus	58-62
9174058-7	1997	Domain analysis studies indicate that both SH3 domains of GRB2 bind to the proline rich region of cbl in quiescent BaF3 cells, whereas GRB2 SH2 domain interacts with a non-contiguous sequence of cbl in transformed cells.	Proline	75-82	Casitas B-lineage lymphoma	Mus musculus	98-101
9144488-4	1997	To address this issue, we have generated a dominant negative mutant of CIITA that lacks the acidic transcription-activating N terminus, but retains the proline/serine/threonine-rich domain.	Proline	152-159	class II major histocompatibility complex transactivator	Homo sapiens	71-76
9171351-0	1997	FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.	Proline	66-73	far upstream element (FUSE) binding protein 1	Mus musculus	0-3
9162111-3	1997	This temperature sensitivity can be suppressed by a mutation in the cox2 gene changing Ala189 of the Cox2 protein to proline.	Proline	117-124	cytochrome c oxidase subunit 2	Saccharomyces cerevisiae S288C	68-72
9162111-3	1997	This temperature sensitivity can be suppressed by a mutation in the cox2 gene changing Ala189 of the Cox2 protein to proline.	Proline	117-124	cytochrome c oxidase subunit 2	Saccharomyces cerevisiae S288C	101-105
9171351-0	1997	FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.	Proline	66-73	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	23-26
9171351-3	1997	A 10 amino acid proline-rich portion of the morphogenic protein, formin, is bound in vitro by both the WW domain of the formin-binding protein 11 (FBP11) and the SH3 domain of Abl.	Proline	16-23	pre-mRNA processing factor 40A	Mus musculus	120-145
9194591-3	1997	In the uPA-encoding cDNA derived from OV-MZ-6 cells (but not in the uPA-cDNA from OVCAR-3 and OV-MZ-19), a so-far unknown mutation was identified in codon 121, resulting in a proline to leucine exchange.	Proline	175-182	plasminogen activator, urokinase	Homo sapiens	7-10
9171351-3	1997	A 10 amino acid proline-rich portion of the morphogenic protein, formin, is bound in vitro by both the WW domain of the formin-binding protein 11 (FBP11) and the SH3 domain of Abl.	Proline	16-23	pre-mRNA processing factor 40A	Mus musculus	147-152
9171351-3	1997	A 10 amino acid proline-rich portion of the morphogenic protein, formin, is bound in vitro by both the WW domain of the formin-binding protein 11 (FBP11) and the SH3 domain of Abl.	Proline	16-23	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	176-179
9171351-5	1997	In so doing, we identified eight ligands (WBP3 through WBP10), each of which contains a proline-rich region or regions.	Proline	88-95	formin-like 3	Mus musculus	42-46
9171351-5	1997	In so doing, we identified eight ligands (WBP3 through WBP10), each of which contains a proline-rich region or regions.	Proline	88-95	methyl CpG binding protein 2	Mus musculus	55-60
9171351-8	1997	These findings support the notion that the FBP11 WW domain and the Abl SH3 domain can compete for the same proline-rich ligands and suggest that at least two subclasses of WW domains exist, namely those that bind a PPLP motif, and those that bind a PPXY motif.	Proline	107-114	pre-mRNA processing factor 40A	Mus musculus	43-48
9171351-8	1997	These findings support the notion that the FBP11 WW domain and the Abl SH3 domain can compete for the same proline-rich ligands and suggest that at least two subclasses of WW domains exist, namely those that bind a PPLP motif, and those that bind a PPXY motif.	Proline	107-114	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	67-70
9149948-4	1997	Peg3 also encodes a Kruppel-type ZNF protein but one that is distinguished from other ZNF gene products by the fact that it carries two novel proline-rich motifs.	Proline	142-149	paternally expressed 3	Homo sapiens	0-4
9149948-5	1997	Comparison between mouse Peg3 and partial human PEG3 gene sequences revealed a high level of conservation between the two species, despite the fact that one of the two proline-rich repeats is absent from the human gene.	Proline	168-175	paternally expressed 3	Homo sapiens	48-52
9176854-5	1997	This missense mutation denotes amino acid substitution of the proline residue for arginine residue at position 145 of apo E.	Proline	62-69	apolipoprotein E	Homo sapiens	118-123
9150722-3	1997	The ZFM1 gene, which consists of 14 exons, encodes a 623-amino acid protein and exons 2, 8 and 12 encode the putative nuclear localisation signal, a zinc finger motif, and a proline-rich region, respectively.	Proline	174-181	splicing factor 1	Homo sapiens	4-8
9150722-6	1997	A 6-bp deletion that resulted in the loss of two proline residues at codons 479 and 480 in exon 12 was found in one MEN1 patient.	Proline	49-56	menin 1	Homo sapiens	116-120
9144770-0	1997	Template-based docking of a prolactin receptor proline-rich motif octapeptide to FKBP12: implications for cytokine receptor signaling.	Proline	47-54	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	81-87
9141561-3	1997	DNA was extracted, the insulin gene amplified by the PCR, and by direct sequencing, a novel point mutation, G1552C, was identified, which resulted in the substitution of proline (CCT) for arginine (CGT) at position 65.	Proline	170-177	insulin	Homo sapiens	23-30
9141561-3	1997	DNA was extracted, the insulin gene amplified by the PCR, and by direct sequencing, a novel point mutation, G1552C, was identified, which resulted in the substitution of proline (CCT) for arginine (CGT) at position 65.	Proline	170-177	CCT	Homo sapiens	179-182
9141561-3	1997	DNA was extracted, the insulin gene amplified by the PCR, and by direct sequencing, a novel point mutation, G1552C, was identified, which resulted in the substitution of proline (CCT) for arginine (CGT) at position 65.	Proline	170-177	UDP glycosyltransferase 8	Homo sapiens	198-201
9111306-3	1997	Here we show by mutational analysis that the FosB C-terminal domain has a proline-based motif that is essential for both of these functions.	Proline	74-81	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-49
9111306-4	1997	Phosphopeptide mapping experiments show that the C terminus of FosB is phosphorylated within a cluster of functionally redundant serine residues that is adjacent to this proline-based motif.	Proline	170-177	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-67
9179853-1	1997	The general amino acid permease, Gap1, of Saccharomyces cerevisiae is very active in cells grown on proline as the sole nitrogen source.	Proline	100-107	amino acid permease GAP1	Saccharomyces cerevisiae S288C	33-37
9144770-0	1997	Template-based docking of a prolactin receptor proline-rich motif octapeptide to FKBP12: implications for cytokine receptor signaling.	Proline	47-54	interleukin 18 receptor 1	Homo sapiens	106-123
9130139-0	1997	NCAM-fibronectin-type-III-domain substrata with and without a six-amino-acid-long proline-rich insert increase the dendritic and axonal arborization of spinal motoneurons.	Proline	82-89	neural cell adhesion molecule 1	Rattus norvegicus	0-4
9135029-8	1997	The modeling studies find strong experimental support from mutagenesis studies on PKC alpha that reveal the crucial role played by the residues proline 11, leucine 20, leucine 24, and glycine 27.	Proline	144-151	protein kinase C alpha	Homo sapiens	82-91
9099734-7	1997	Using in vitro binding assays, RAFTK and paxillin were shown to bind directly through the C-terminal proline-rich domain.	Proline	101-108	protein tyrosine kinase 2 beta	Homo sapiens	31-36
9099734-7	1997	Using in vitro binding assays, RAFTK and paxillin were shown to bind directly through the C-terminal proline-rich domain.	Proline	101-108	paxillin	Homo sapiens	41-49
9146705-10	1997	Finally, a PEST algorithm has identified a PEST (proline, glutamate, serine, threonine) motif within the catalytic subunit of gamma-GCS, suggesting that this subunit might exhibit conditional proteolytic regulation.	Proline	49-56	glutamate-cysteine ligase catalytic subunit	Homo sapiens	126-135
9114050-0	1997	A proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1.	Proline	2-9	transformation related protein 53, pseudogene	Mus musculus	24-27
9114050-0	1997	A proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1.	Proline	2-9	growth arrest specific 1	Mus musculus	100-104
9114050-5	1997	Through a detailed deletional analysis and site-specific mutagenesis of p53 we show that the Gas1-dependent signal transduction relies on a proline-rich region (amino acids 63-85) of murine p53.	Proline	140-147	transformation related protein 53, pseudogene	Mus musculus	72-75
9114050-5	1997	Through a detailed deletional analysis and site-specific mutagenesis of p53 we show that the Gas1-dependent signal transduction relies on a proline-rich region (amino acids 63-85) of murine p53.	Proline	140-147	growth arrest specific 1	Mus musculus	93-97
9114050-5	1997	Through a detailed deletional analysis and site-specific mutagenesis of p53 we show that the Gas1-dependent signal transduction relies on a proline-rich region (amino acids 63-85) of murine p53.	Proline	140-147	transformation related protein 53, pseudogene	Mus musculus	190-193
9099683-0	1997	Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain.	Proline	100-107	diacylglycerol kinase beta	Homo sapiens	25-46
9099683-0	1997	Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain.	Proline	100-107	diacylglycerol kinase theta	Homo sapiens	48-56
9099683-11	1997	DGKtheta furthermore contains various domains for protein-protein interaction, such as a proline- and glycine-rich domain with a putative SH3 domain-binding site and a pleckstrin homology domain with an overlapping Ras-associating domain.	Proline	89-96	diacylglycerol kinase theta	Homo sapiens	0-8
9108392-3	1997	These domains bind to proteins containing proline-rich regions or tyrosine-phosphorylated proteins and contribute to the association of Grb2/Ash and Shc with other signaling molecules.	Proline	42-49	growth factor receptor bound protein 2	Homo sapiens	136-140
9108392-3	1997	These domains bind to proteins containing proline-rich regions or tyrosine-phosphorylated proteins and contribute to the association of Grb2/Ash and Shc with other signaling molecules.	Proline	42-49	growth factor receptor bound protein 2	Homo sapiens	141-144
9108392-3	1997	These domains bind to proteins containing proline-rich regions or tyrosine-phosphorylated proteins and contribute to the association of Grb2/Ash and Shc with other signaling molecules.	Proline	42-49	SHC adaptor protein 1	Homo sapiens	149-152
9135065-1	1997	The involvement of murine protein tyrosine phosphatase-PEST (MPTP-PEST) in signal transduction pathways is suggested by its ability to dephosphorylate phosphotyrosine residues, its interaction with the adaptor protein SHC and by the presence of five proline-rich stretches in its non-catalytic carboxyl terminus.	Proline	250-257	protein tyrosine phosphatase, non-receptor type 12	Mus musculus	19-59
9135065-1	1997	The involvement of murine protein tyrosine phosphatase-PEST (MPTP-PEST) in signal transduction pathways is suggested by its ability to dephosphorylate phosphotyrosine residues, its interaction with the adaptor protein SHC and by the presence of five proline-rich stretches in its non-catalytic carboxyl terminus.	Proline	250-257	protein tyrosine phosphatase, non-receptor type 12	Mus musculus	61-70
9135065-1	1997	The involvement of murine protein tyrosine phosphatase-PEST (MPTP-PEST) in signal transduction pathways is suggested by its ability to dephosphorylate phosphotyrosine residues, its interaction with the adaptor protein SHC and by the presence of five proline-rich stretches in its non-catalytic carboxyl terminus.	Proline	250-257	src homology 2 domain-containing transforming protein C1	Mus musculus	218-221
9135065-4	1997	In vitro binding assays indicate that four of these proline-rich sequences constitute specific binding sites for both SH3 domains of the adaptor molecule Grb2.	Proline	52-59	growth factor receptor bound protein 2	Mus musculus	154-158
9135077-2	1997	We show that CYR61 encodes a 381 amino acid protein rich in cysteine and proline residues that is strongly conserved with the mouse homologue.	Proline	73-80	cellular communication network factor 1	Mus musculus	13-18
9126384-5	1997	In addition, the approximately 60-amino-acid-long SH3 domains of Src and Abl were fused to AP and the resulting fusion proteins were found to bind specifically to their respective peptide ligands in microtiter plates and proteins containing proline-rich regions in screens of a lambda cDNA expression library.	Proline	241-248	Rous sarcoma oncogene	Mus musculus	65-68
9083066-6	1997	The first of the two motifs determined to elicit NGF specificity is defined by the residues Val-48, Pro-49, and Gln-96, which are situated in the two top beta-loops of NGF.	Proline	100-103	nerve growth factor	Homo sapiens	49-52
9083066-6	1997	The first of the two motifs determined to elicit NGF specificity is defined by the residues Val-48, Pro-49, and Gln-96, which are situated in the two top beta-loops of NGF.	Proline	100-103	nerve growth factor	Homo sapiens	168-171
9092826-2	1997	The effect of binding a proline-rich peptide derived from the protein Sos, a biological target of the drkN SH3 domain, on this equilibrium has been investigated.	Proline	24-31	Son of sevenless	Drosophila melanogaster	70-73
9097020-2	1997	mSAP49 contains two RNA recognition motifs (RRM) in the N terminus of the predicted amino acid sequence, and a highly basic C terminus rich in glycine/proline.	Proline	151-158	splicing factor 3b, subunit 4	Mus musculus	0-6
9083043-7	1997	Furthermore, the isolated SH3 domain of p40(phox) was even more effective in inhibiting whole cell oxidase activity, consistent with experiments showing that this domain binds to the same proline-rich target in p47(phox) (residues 358-390) that interacts with p67(phox).	Proline	188-195	interleukin 9	Homo sapiens	40-43
9083043-7	1997	Furthermore, the isolated SH3 domain of p40(phox) was even more effective in inhibiting whole cell oxidase activity, consistent with experiments showing that this domain binds to the same proline-rich target in p47(phox) (residues 358-390) that interacts with p67(phox).	Proline	188-195	interleukin 9	Homo sapiens	44-48
9083043-7	1997	Furthermore, the isolated SH3 domain of p40(phox) was even more effective in inhibiting whole cell oxidase activity, consistent with experiments showing that this domain binds to the same proline-rich target in p47(phox) (residues 358-390) that interacts with p67(phox).	Proline	188-195	pleckstrin	Homo sapiens	211-214
9083043-7	1997	Furthermore, the isolated SH3 domain of p40(phox) was even more effective in inhibiting whole cell oxidase activity, consistent with experiments showing that this domain binds to the same proline-rich target in p47(phox) (residues 358-390) that interacts with p67(phox).	Proline	188-195	interleukin 9	Homo sapiens	215-219
9083043-7	1997	Furthermore, the isolated SH3 domain of p40(phox) was even more effective in inhibiting whole cell oxidase activity, consistent with experiments showing that this domain binds to the same proline-rich target in p47(phox) (residues 358-390) that interacts with p67(phox).	Proline	188-195	CD33 molecule	Homo sapiens	260-263
9083043-7	1997	Furthermore, the isolated SH3 domain of p40(phox) was even more effective in inhibiting whole cell oxidase activity, consistent with experiments showing that this domain binds to the same proline-rich target in p47(phox) (residues 358-390) that interacts with p67(phox).	Proline	188-195	interleukin 9	Homo sapiens	215-219
9142991-5	1997	MIG-10 proteins do not contain an SH2 domain, but share with the Grbs a pleckstrin homology (PH) domain and proline-rich regions, features commonly found in signal transduction proteins.	Proline	108-115	Abnormal cell migration protein 10	Caenorhabditis elegans	0-6
9126384-5	1997	In addition, the approximately 60-amino-acid-long SH3 domains of Src and Abl were fused to AP and the resulting fusion proteins were found to bind specifically to their respective peptide ligands in microtiter plates and proteins containing proline-rich regions in screens of a lambda cDNA expression library.	Proline	241-248	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	73-76
9133417-4	1997	Jak3 is constitutively associated with CD40, and this interaction requires a proline-rich sequence in the membrane-proximal region of CD40.	Proline	77-84	Janus kinase 3	Homo sapiens	0-4
9099850-8	1997	Nm23-H4 naturally possesses the Pro-Ser substitution equivalent to the K-pn mutation (P97S) of Drosophila.	Proline	32-35	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-4
9133417-4	1997	Jak3 is constitutively associated with CD40, and this interaction requires a proline-rich sequence in the membrane-proximal region of CD40.	Proline	77-84	CD40 molecule	Homo sapiens	39-43
9133417-4	1997	Jak3 is constitutively associated with CD40, and this interaction requires a proline-rich sequence in the membrane-proximal region of CD40.	Proline	77-84	CD40 molecule	Homo sapiens	134-138
9119896-0	1997	Reversible tyrosine phosphorylation/dephosphorylation of proline-directed protein kinase FA/glycogen synthase kinase-3alpha in A431 cells.	Proline	57-64	glycogen synthase kinase 3 alpha	Homo sapiens	92-123
9079929-1	1997	Transcription of the proP gene, encoding a transporter of the osmoprotectants proline and glycine betaine, is controlled from two promoters, P1 and P2, that respond primarily to osmotic and stationary-phase signals, respectively.	Proline	78-85	replication initiation protein	Escherichia coli	141-150
9209371-5	1997	The function of MTG8 is assumed to be as a transcription factor, because it possesses several features common to transcription factors; putative zinc finger motifs, serine/threonine/proline-rich sequences and a region similar to TAF110.	Proline	182-189	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	16-20
9084448-1	1997	A proportion of the neuronal microtubule-associated protein (MAP) tau is highly phosphorylated in foetal and adult brain, whereas the majority of tau in the neurofibrillary tangles of Alzheimer"s patients is hyperphosphorylated; many of the phosphorylation sites are serines or threonines followed by prolines.	Proline	301-309	regulator of microtubule dynamics 3	Homo sapiens	29-59
9084448-1	1997	A proportion of the neuronal microtubule-associated protein (MAP) tau is highly phosphorylated in foetal and adult brain, whereas the majority of tau in the neurofibrillary tangles of Alzheimer"s patients is hyperphosphorylated; many of the phosphorylation sites are serines or threonines followed by prolines.	Proline	301-309	regulator of microtubule dynamics 3	Homo sapiens	61-64
9084448-3	1997	We have now shown that purified recombinant stress-activated protein kinase/c-Jun N-terminal kinase, a proline-directed kinase of the MAP kinase extended family, phosphorylates recombinant tau in vitro on threonine and serine residues.	Proline	103-110	mitogen-activated protein kinase 8	Homo sapiens	78-99
9084448-3	1997	We have now shown that purified recombinant stress-activated protein kinase/c-Jun N-terminal kinase, a proline-directed kinase of the MAP kinase extended family, phosphorylates recombinant tau in vitro on threonine and serine residues.	Proline	103-110	regulator of microtubule dynamics 3	Homo sapiens	134-137
9089084-5	1997	Although divergence is high, conservation among insect, vertebrate, and nematode Vg sequences is widespread with a preponderance of glycine, proline, and cysteine residues among strictly conserved amino acids, establishing conclusively that Vgs from the three phyla are homologous.	Proline	141-148	putative uncharacterized protein LOC400499	Homo sapiens	81-83
9060613-2	1997	Using the yeast two-hybrid system, we identified the SH3 domain of c-Abl as interacting with the proline-rich p12 domain of Pr60gag.	Proline	97-104	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	67-72
9209410-4	1997	Furthermore, we revealed that two proline residues in the box1 region, which is conserved in the IL-2 receptor beta chain and the alpha chains of the cytokine receptors, are essentially involved in association with Jak1.	Proline	34-41	interleukin 2 receptor subunit beta	Homo sapiens	97-115
9079650-11	1997	MEKK4 has a putative pleckstrin homology domain and a proline-rich motif, suggesting specific regulatory functions different from those of the previously characterized MEKKs.	Proline	54-61	mitogen-activated protein kinase kinase kinase 4	Mus musculus	0-5
9209410-4	1997	Furthermore, we revealed that two proline residues in the box1 region, which is conserved in the IL-2 receptor beta chain and the alpha chains of the cytokine receptors, are essentially involved in association with Jak1.	Proline	34-41	Janus kinase 1	Homo sapiens	215-219
9079622-1	1997	Based on the presence of multiple proline-rich motifs in the huntingtin sequence, we tested its possible association with epidermal growth factor (EGF) receptor signaling complexes through SH3 domain-containing modules.	Proline	34-41	huntingtin	Homo sapiens	61-71
9079622-1	1997	Based on the presence of multiple proline-rich motifs in the huntingtin sequence, we tested its possible association with epidermal growth factor (EGF) receptor signaling complexes through SH3 domain-containing modules.	Proline	34-41	epidermal growth factor receptor	Homo sapiens	122-160
9121472-1	1997	The human proto-oncogene product c-Cbl and a similar protein in Caenorhabditis elegans (Sli-1) contain a proline-rich COOH-terminal region that binds Src homology 3 (SH3) domains of proteins such as the adapter Grb2.	Proline	105-112	Cbl proto-oncogene	Homo sapiens	33-38
9121472-1	1997	The human proto-oncogene product c-Cbl and a similar protein in Caenorhabditis elegans (Sli-1) contain a proline-rich COOH-terminal region that binds Src homology 3 (SH3) domains of proteins such as the adapter Grb2.	Proline	105-112	E3 ubiquitin-protein ligase CBL	Caenorhabditis elegans	88-93
9121472-1	1997	The human proto-oncogene product c-Cbl and a similar protein in Caenorhabditis elegans (Sli-1) contain a proline-rich COOH-terminal region that binds Src homology 3 (SH3) domains of proteins such as the adapter Grb2.	Proline	105-112	downstream of receptor kinase	Drosophila melanogaster	211-215
9121472-3	1997	Here we identify by molecular cloning a Drosophila cDNA encoding a protein (Drosophila Cbl [D-Cbl]) that shows high sequence similarity to the N-terminal region of human c-Cbl but lacks proline-rich sequences and fails to bind Grb2.	Proline	186-193	Cbl proto-oncogene	Drosophila melanogaster	87-90
9087167-0	1997	Modulation of Src homology 3 proteins by the proline-rich adaptor protein Shb.	Proline	45-52	Rous sarcoma oncogene	Mus musculus	14-17
9108297-5	1997	Thus, ABA-treated abi1-1 mutant plants accumulated less proline than the ABA-treated wild type.	Proline	56-63	Protein phosphatase 2C family protein	Arabidopsis thaliana	18-24
9108297-6	1997	Upon salt stress, proline accumulated to a lesser extent in aba1-1 and abi1-1 mutant plants, suggesting an indirect role of ABA on proline accumulation during salt adaptation of the plant.	Proline	18-25	Protein phosphatase 2C family protein	Arabidopsis thaliana	71-77
9108297-6	1997	Upon salt stress, proline accumulated to a lesser extent in aba1-1 and abi1-1 mutant plants, suggesting an indirect role of ABA on proline accumulation during salt adaptation of the plant.	Proline	131-138	Protein phosphatase 2C family protein	Arabidopsis thaliana	71-77
9091579-6	1997	RAFTK also co-immunoprecipitates with the SH2 domain of Lck and with the cytoskeletal protein paxillin through its COOH-terminal proline-rich domain.	Proline	129-136	protein tyrosine kinase 2 beta	Homo sapiens	0-5
9091579-6	1997	RAFTK also co-immunoprecipitates with the SH2 domain of Lck and with the cytoskeletal protein paxillin through its COOH-terminal proline-rich domain.	Proline	129-136	paxillin	Homo sapiens	94-102
9108263-2	1997	Prolyl endopeptidase is one such enzyme, which cleaves on the carboxyl side of proline within peptide substrates.	Proline	79-86	prolyl endopeptidase	Bos taurus	0-20
9087167-0	1997	Modulation of Src homology 3 proteins by the proline-rich adaptor protein Shb.	Proline	45-52	src homology 2 domain-containing transforming protein B	Mus musculus	74-77
9135138-4	1997	An extreme example of receptor co-operativity was encountered when testing Ram-1-targeted AMOPRO envelopes with specific proline-rich interdomain spacers.	Proline	121-128	solute carrier family 20 member 2	Homo sapiens	75-80
9087167-1	1997	In the present study we have investigated a possible role for the proline-rich SH2 domain protein Shb as a regulator of expression or activity of certain SH3 domain proteins and MAP kinase.	Proline	66-73	src homology 2 domain-containing transforming protein B	Mus musculus	98-101
9032343-2	1997	Elucidation of the biochemical role of CyPA would be aided by a detailed analysis of the genetic requirements for the formation of the Gag-CyPA complex; previous experiments have demonstrated the requirement for a critical proline and the immediately preceding glycine, located within the capsid domain of Gag, but nothing is known about the necessary CyPA residues.	Proline	223-230	peptidylprolyl isomerase A	Homo sapiens	39-43
9045710-7	1997	Both purified sarcosine oxidase and a recombinant fusion protein synthesized in Escherichia coli contain a covalently bound flavin, metabolize sarcosine, L-pipecolic acid, and L-proline, and cross-react with antibodies raised against L-pipecolic acid oxidase from monkey liver.	Proline	176-185	peroxisomal sarcosine oxidase	Oryctolagus cuniculus	14-31
9118959-4	1997	The cytoplasmic domain of Caspr contains a proline-rich sequence capable of binding to a subclass of SH3 domains of signaling molecules.	Proline	43-50	contactin associated protein 1	Rattus norvegicus	26-31
9124567-7	1997	Compared with control, cortisol administration increased 1) the activities of ASL and arginase and the production of CO(2), ornithine, and proline from arginine, and 2) P5C synthase activity and the formation of glutamate, alanine, aspartate, ornithine, citrulline, proline, and CO(2) from glutamine in enterocytes.	Proline	139-146	argininosuccinate lyase	Sus scrofa	78-81
9088775-1	1997	Lys(B28)Pro(B29) human insulin analogue (Lispro) is a newly developed monomeric insulin analogue with a rapid onset and short duration of action.	Proline	8-11	MIS18 kinetochore protein A	Homo sapiens	0-7
9088775-1	1997	Lys(B28)Pro(B29) human insulin analogue (Lispro) is a newly developed monomeric insulin analogue with a rapid onset and short duration of action.	Proline	8-11	insulin	Homo sapiens	23-30
9088775-1	1997	Lys(B28)Pro(B29) human insulin analogue (Lispro) is a newly developed monomeric insulin analogue with a rapid onset and short duration of action.	Proline	8-11	insulin	Homo sapiens	80-87
9050928-3	1997	SH3BGR encodes a novel protein that is characterized by the presence of a proline-rich region containing the consensus sequence for a SH3-binding domain and by an acidic carboxyl-terminal region containing a glutamic acid-rich domain predicted to assume a coiled coil.	Proline	74-81	SH3 domain binding glutamate rich protein	Homo sapiens	0-6
9092938-7	1997	Mutagenesis of the glutamine residue at position 244 in the homologous region of alpha-glucosidase to proline results in a protein that is neither transported to the lysosomes nor secreted extracellularly but accumulates in the ER, intermediate compartment and cis-Golgi as a mannose-rich polypeptide similar to mutant sucrase-isomaltase in phenotype II.	Proline	102-109	sucrase-isomaltase	Homo sapiens	81-98
9092938-7	1997	Mutagenesis of the glutamine residue at position 244 in the homologous region of alpha-glucosidase to proline results in a protein that is neither transported to the lysosomes nor secreted extracellularly but accumulates in the ER, intermediate compartment and cis-Golgi as a mannose-rich polypeptide similar to mutant sucrase-isomaltase in phenotype II.	Proline	102-109	sucrase-isomaltase	Homo sapiens	319-337
9125210-0	1997	Association of elongation factor 1 alpha and ribosomal protein L3 with the proline-rich region of yeast adenylyl cyclase-associated protein CAP.	Proline	75-82	ribonuclease A family member 4	Rattus norvegicus	63-65
9125160-5	1997	Mutation of the threonine at position 340 in the sixth transmembrane spanning domain to proline (T340P) led to agonist-independent constitutive activity and exhibited a four-fold increase in basal cAMP level as compared to the wild-type GIP-R.	Proline	88-95	gastric inhibitory polypeptide receptor	Homo sapiens	237-242
9395435-9	1997	Mutation of a proline residue within a conserved SH3-binding region at the amino terminus of Pak1 interferes with SH3-protein binding and alters the effects of Pak1 on the cytoskeleton.	Proline	14-21	p21 (RAC1) activated kinase 1	Homo sapiens	93-97
9395435-9	1997	Mutation of a proline residue within a conserved SH3-binding region at the amino terminus of Pak1 interferes with SH3-protein binding and alters the effects of Pak1 on the cytoskeleton.	Proline	14-21	p21 (RAC1) activated kinase 1	Homo sapiens	160-164
9032268-1	1997	The E2A-HLF fusion gene, created by the t(17;19)(q22;p13) chromosomal translocation in pro-B lymphocytes, encodes an oncogenic protein in which the E2A trans-activation domain is linked to the DNA-binding and protein dimerization domain of hepatic leukemia factor (HLF), a member of the proline- and acidic amino acid-rich (PAR) subfamily of bZIP transcription factors.	Proline	287-294	hepatic leukemia factor	Mus musculus	8-11
9032268-1	1997	The E2A-HLF fusion gene, created by the t(17;19)(q22;p13) chromosomal translocation in pro-B lymphocytes, encodes an oncogenic protein in which the E2A trans-activation domain is linked to the DNA-binding and protein dimerization domain of hepatic leukemia factor (HLF), a member of the proline- and acidic amino acid-rich (PAR) subfamily of bZIP transcription factors.	Proline	287-294	hepatic leukemia factor	Mus musculus	240-263
9032268-1	1997	The E2A-HLF fusion gene, created by the t(17;19)(q22;p13) chromosomal translocation in pro-B lymphocytes, encodes an oncogenic protein in which the E2A trans-activation domain is linked to the DNA-binding and protein dimerization domain of hepatic leukemia factor (HLF), a member of the proline- and acidic amino acid-rich (PAR) subfamily of bZIP transcription factors.	Proline	287-294	hepatic leukemia factor	Mus musculus	265-268
9032343-2	1997	Elucidation of the biochemical role of CyPA would be aided by a detailed analysis of the genetic requirements for the formation of the Gag-CyPA complex; previous experiments have demonstrated the requirement for a critical proline and the immediately preceding glycine, located within the capsid domain of Gag, but nothing is known about the necessary CyPA residues.	Proline	223-230	Pr55(Gag)	Human immunodeficiency virus 1	135-138
9032343-7	1997	These studies indicate that, as with other proline-containing peptides or cyclosporine A, HIV-1 Gag directly contacts residues in the hydrophobic pocket of CyPA.	Proline	43-50	Pr55(Gag)	Human immunodeficiency virus 1	96-99
9032343-7	1997	These studies indicate that, as with other proline-containing peptides or cyclosporine A, HIV-1 Gag directly contacts residues in the hydrophobic pocket of CyPA.	Proline	43-50	peptidylprolyl isomerase A	Homo sapiens	156-160
9047311-5	1997	Analysis of the P3 structure influence on substrate efficiency demonstrates that compounds which contain D-isomers of N-blocked bulky amino acids, such as Phe, Leu, and Val, in this position are more efficient for tPA than substrates with N-unblocked small amino acids (Ser or Pro) in the P3 position.	Proline	277-280	plasminogen activator, tissue type	Homo sapiens	214-217
9163848-8	1997	In this disease, apo E Sendai which results from new substitution (Arginine 145--&gt;Proline) may induce intraglomerular lipoprotein thrombi characteristic of lipoprotein glomerulopathy.	Proline	85-92	apolipoprotein E	Homo sapiens	17-22
9038154-1	1997	Requirements for Src kinase activity and FAK proline-rich motifs.	Proline	45-52	protein tyrosine kinase 2	Homo sapiens	41-44
9038154-7	1997	FAK-Cas association was only observed in the context of Cas binding to at least one of two distinct proline-rich sites on FAK.	Proline	100-107	protein tyrosine kinase 2	Homo sapiens	0-3
9038154-7	1997	FAK-Cas association was only observed in the context of Cas binding to at least one of two distinct proline-rich sites on FAK.	Proline	100-107	BCAR1 scaffold protein, Cas family member	Homo sapiens	4-7
9038154-7	1997	FAK-Cas association was only observed in the context of Cas binding to at least one of two distinct proline-rich sites on FAK.	Proline	100-107	BCAR1 scaffold protein, Cas family member	Homo sapiens	56-59
9038154-7	1997	FAK-Cas association was only observed in the context of Cas binding to at least one of two distinct proline-rich sites on FAK.	Proline	100-107	protein tyrosine kinase 2	Homo sapiens	122-125
9038199-5	1997	PCDC5RP contains two tandem repeats of a helix-turn-helix DNA binding motif, four consensus nuclear localization signals, and a hydrophilic, proline-rich central region similar to the transcriptional activating domain in Myb family members.	Proline	141-148	cell division cycle 5 like	Homo sapiens	0-7
9049254-2	1997	cDNA cloning indicates that CALEB is a multidomain protein that consists of an NH2-terminal glycosylation region, a leucine-proline-rich segment, an acidic box, a single EGF-like domain, a transmembrane, and a short cytoplasmic stretch.	Proline	124-131	chondroitin sulfate proteoglycan 5	Gallus gallus	28-33
9030521-4	1997	Assembly of the cytochrome bc1 complex and the respiratory deficient phenotype of the cor2-45 mutant are restored by the proline for serine replacement in cytochrome b.	Proline	121-128	ubiquinol--cytochrome-c reductase subunit 2	Saccharomyces cerevisiae S288C	86-90
9030521-4	1997	Assembly of the cytochrome bc1 complex and the respiratory deficient phenotype of the cor2-45 mutant are restored by the proline for serine replacement in cytochrome b.	Proline	121-128	cytochrome b	Saccharomyces cerevisiae S288C	16-28
9020091-6	1997	Specifically, after Gly40 and Thr45 in the putative effector domain of ARF1 were replaced with the equivalent Asp and Pro, respectively, from p3, functional interaction of the chimeric ARF1 with p5 was increased.	Proline	118-121	ADP ribosylation factor 1	Homo sapiens	71-75
9049300-4	1997	The predicted amino acid sequence of p66shc overlaps that of p52shc and contains a unique N-terminal region which is also rich in glycines and prolines (CH2).	Proline	143-151	src homology 2 domain-containing transforming protein C1	Mus musculus	37-43
9059515-2	1997	Human LCAT is a glycosylated protein, containing 416 amino acids and a proline-rich region at the C-terminus.	Proline	71-78	lecithin-cholesterol acyltransferase	Homo sapiens	6-10
9059515-9	1997	However, deletions of the proline-rich region, including the five amino acids nearest to the C-terminus, resulted in approximately an 8-fold increase in the specific activity of LCAT towards the water-soluble substrate, p-nitrophenylbutyrate.	Proline	26-33	lecithin-cholesterol acyltransferase	Homo sapiens	178-182
9059515-10	1997	This suggests that the C-terminal proline-rich region may interfere with the access of this water-soluble substrate to the active site of LCAT, and may form part of a protective covering of the active site of LCAT while in solution.	Proline	34-41	lecithin-cholesterol acyltransferase	Homo sapiens	138-142
9059515-10	1997	This suggests that the C-terminal proline-rich region may interfere with the access of this water-soluble substrate to the active site of LCAT, and may form part of a protective covering of the active site of LCAT while in solution.	Proline	34-41	lecithin-cholesterol acyltransferase	Homo sapiens	209-213
9020091-6	1997	Specifically, after Gly40 and Thr45 in the putative effector domain of ARF1 were replaced with the equivalent Asp and Pro, respectively, from p3, functional interaction of the chimeric ARF1 with p5 was increased.	Proline	118-121	ADP ribosylation factor 1	Homo sapiens	185-189
9020138-7	1997	In addition, the two molecules were detected in p53/56(Lyn) immunoprecipitates, and Lyn kinase was found to specifically bind the C-terminal proline-rich sequence of Cas in an in vitro binding assay.	Proline	141-148	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	84-87
9020138-7	1997	In addition, the two molecules were detected in p53/56(Lyn) immunoprecipitates, and Lyn kinase was found to specifically bind the C-terminal proline-rich sequence of Cas in an in vitro binding assay.	Proline	141-148	BCAR1 scaffold protein, Cas family member	Homo sapiens	166-169
9053855-5	1997	Both GAL4DBD/Evi-1 fusion and non-fusion proteins have been used to map the repressor activity to a proline-rich region located within amino acids 514-724 between the ZF1 and ZF2 domains.	Proline	100-107	MDS1 and EVI1 complex locus	Homo sapiens	13-18
9034331-3	1997	On the other hand, fluorescence spectroscopy reveals that proline-rich peptides bind better to profilin II.	Proline	58-65	profilin 2	Homo sapiens	95-106
9034331-4	1997	At micromolar concentrations, profilin II dimerizes upon binding to proline-rich peptides.	Proline	68-75	profilin 2	Homo sapiens	30-41
9053855-5	1997	Both GAL4DBD/Evi-1 fusion and non-fusion proteins have been used to map the repressor activity to a proline-rich region located within amino acids 514-724 between the ZF1 and ZF2 domains.	Proline	100-107	zinc finger protein 274	Homo sapiens	175-178
9065197-5	1997	Conceptual translation of the complementary deoxyribonucleic acid predicted a novel protein of 154 amino acids that is proline rich and acidic (pregnancy-specific uterine protein).	Proline	119-126	proline-rich acidic protein 1	Mus musculus	144-178
9070220-5	1997	In addition to the SH2 domain binding sites, a proline-rich putative SH3 domain binding site was detected in the cytoplasmic region of SHPS-1.	Proline	47-54	signal-regulatory protein alpha	Mus musculus	135-141
9089417-1	1997	BTEB2 is a GC box-binding transcription factor containing proline-rich and zinc finger domains as transactivation and DNA binding domains, respectively.	Proline	58-65	Kruppel like factor 5	Homo sapiens	0-5
9113408-7	1997	Ascidians and the protostome invertebrate Drosophila produce long and short TnI isoforms (the longer isoforms containing a proline-rich block of extra sequence near the N-terminus) by an alternative RNA splicing mechanism from a single gene.	Proline	123-130	wings up A	Drosophila melanogaster	76-79
9017204-0	1997	Bilayer interactions of indolicidin, a small antimicrobial peptide rich in tryptophan, proline, and basic amino acids.	Proline	87-94	cathelicidin-4	Bos taurus	24-35
9017204-2	1997	Indolicidin, an antimicrobial 13-residue peptide-amide isolated from the cytoplasmic granules of bovine neutrophils, is highly enriched in these amino acids: five tryptophans, three prolines, three basic residues, and no acidic residues.	Proline	182-190	cathelicidin-4	Bos taurus	0-11
9343926-0	1997	Interaction of SH3 domain of Hck tyrosine kinase with cellular proteins containing proline-rich regions: evidence for modulation by unique domain.	Proline	83-90	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
9089417-7	1997	Initiation factors, TFIIB, TFIIE beta, and TFIIF beta as well as the TATA box-binding protein (TBP) were found to interact with BTEB2 when analyzed by in vitro binding experiments, although these interactions could not be attributed to the proline-rich domain.	Proline	240-247	TATA-box binding protein	Homo sapiens	95-98
9089417-7	1997	Initiation factors, TFIIB, TFIIE beta, and TFIIF beta as well as the TATA box-binding protein (TBP) were found to interact with BTEB2 when analyzed by in vitro binding experiments, although these interactions could not be attributed to the proline-rich domain.	Proline	240-247	Kruppel like factor 5	Homo sapiens	128-133
9149329-1	1997	Previous research in this laboratory has shown that major depression is accompanied by decreased serum activity of dipeptidyl peptidase IV (DPP IV), a serine protease that cleaves N terminal dipeptides from peptides with penultimate proline or alanine.	Proline	233-240	dipeptidyl peptidase 4	Homo sapiens	115-138
9149329-1	1997	Previous research in this laboratory has shown that major depression is accompanied by decreased serum activity of dipeptidyl peptidase IV (DPP IV), a serine protease that cleaves N terminal dipeptides from peptides with penultimate proline or alanine.	Proline	233-240	dipeptidyl peptidase 4	Homo sapiens	140-146
9020981-6	1997	Specifically, the pro-radical C-3 and C-6 atoms are aligned opposite the abstractable H-5" (pro-S) proton of C6 and the H-1" proton of C6" on partner strands, respectively, in the complex.	Proline	92-97	complement C3	Homo sapiens	30-33
9086566-1	1997	A polymorphism in codon 52 of the human thyrotropin receptor results in a proline to threonine substitution in the extracellular domain of the receptor, and it has been suggested that the rarer, 52Thr, allele is associated with susceptibility to Graves" disease in the female population.	Proline	74-81	thyroid stimulating hormone receptor	Homo sapiens	40-60
9006942-7	1997	Activation of the proline-directed kinases Erk1/2, JNKs, and p38 was neither necessary nor sufficient for stress-induced PTP-1B phosphorylation.	Proline	18-25	mitogen-activated protein kinase 3	Homo sapiens	43-49
9006942-7	1997	Activation of the proline-directed kinases Erk1/2, JNKs, and p38 was neither necessary nor sufficient for stress-induced PTP-1B phosphorylation.	Proline	18-25	mitogen-activated protein kinase 1	Homo sapiens	61-64
9053847-6	1997	Moreover, detection of ThaI polymorphism of codon 72 showed that MCF-7 cells predominantly express wild-type p53 with proline, while mutated p53 in MCF-7/Adr cells contains an arginine residue at codon 72.	Proline	118-125	tumor protein p53	Homo sapiens	109-112
8999895-6	1997	Subsequent amino acid sequencing revealed many peptides involving involucrin cross-linked either to itself or to a variety of other known CE protein components, including cystatin alpha, desmoplakin, elafin, keratins, members of the small proline-rich superfamily, loricrin, and unknown proteins related to the desmoplakin family.	Proline	239-246	involucrin	Homo sapiens	66-76
9000562-3	1997	In addition, a proline-rich region, located in the COOH-terminal portion of eps15, can bind to the Src homology 3 domain of the crk proto-oncogene product in vitro.	Proline	15-22	epidermal growth factor receptor pathway substrate 15	Homo sapiens	76-81
9000562-3	1997	In addition, a proline-rich region, located in the COOH-terminal portion of eps15, can bind to the Src homology 3 domain of the crk proto-oncogene product in vitro.	Proline	15-22	CRK proto-oncogene, adaptor protein	Homo sapiens	128-131
9020981-6	1997	Specifically, the pro-radical C-3 and C-6 atoms are aligned opposite the abstractable H-5" (pro-S) proton of C6 and the H-1" proton of C6" on partner strands, respectively, in the complex.	Proline	92-97	complement C6	Homo sapiens	38-41
9020982-15	1997	Specifically, the pro-radical C-3 and C-6 atoms are aligned opposite the abstractable H-5" (pro-S) and H-4" protons on partner strands across the minor groove, respectively, in the complex.	Proline	92-97	complement C6	Homo sapiens	38-41
8985255-7	1997	Formation of this intramolecular SH3-ligand complex prevents the Itk SH3 domain and proline-rich region from interacting with their respective protein ligands, Sam68 and Grb-2.	Proline	84-91	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	160-165
8985255-7	1997	Formation of this intramolecular SH3-ligand complex prevents the Itk SH3 domain and proline-rich region from interacting with their respective protein ligands, Sam68 and Grb-2.	Proline	84-91	growth factor receptor bound protein 2	Homo sapiens	170-175
9381973-5	1997	In rat adipocytes PHAS-I is phosphorylated in at least five sites, all of which conform to the consensus, (Ser/Thr)-Pro.	Proline	116-119	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	18-24
9000508-0	1997	The role of the proline-rich region in A1-type myosin essential light chains: implications for information transmission in the actomyosin complex.	Proline	16-23	myosin heavy chain 14	Homo sapiens	47-53
9000508-1	1997	The proline-rich region of A1-type myosin essential light chains functions as a spacer arm separating an actin binding site at the extreme N-terminus from the remainder of the protein.	Proline	4-11	myosin heavy chain 14	Homo sapiens	35-41
8995252-3	1997	The structure of RAFTK is similar to p125FAK in that it lacks a transmembrane region, does not contain Src homology 2 or 3 domains, and has a proline-rich region in its C terminus.	Proline	142-149	protein tyrosine kinase 2 beta	Homo sapiens	17-22
8995252-3	1997	The structure of RAFTK is similar to p125FAK in that it lacks a transmembrane region, does not contain Src homology 2 or 3 domains, and has a proline-rich region in its C terminus.	Proline	142-149	protein tyrosine kinase 2	Homo sapiens	37-44
8978305-2	1997	We have mapped the site of interaction of CRKL and BCR-ABL to the amino terminal SH3 domain of CRKL with a proline rich region in the C-terminus of ABL.	Proline	107-114	CRK like proto-oncogene, adaptor protein	Homo sapiens	42-46
9090439-0	1997	Stimulatory effect of ovine colostrinine (a proline-rich polypeptide) on interferons and tumor necrosis factor production by murine resident peritoneal cells.	Proline	44-51	tumor necrosis factor	Mus musculus	89-110
9090439-1	1997	We describe effects of ovine colostrinine (proline-rich polypeptide--PRP) isolated from ovine colostrum and nonapeptide fragment of PRP on interferon (IFN) and tumor necrosis factor (TNF) production by murine resident peritoneal cells (RPC).	Proline	43-50	tumor necrosis factor	Mus musculus	160-181
8978305-6	1997	Our data suggest that the interaction between CRKL and the proline deletion mutant of BCR-ABL is an indirect interaction as CRKL does not interact directly with the proline deletion mutant of BCR-ABL in a gel overlay assay or in a yeast two-hybrid assay.	Proline	59-66	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	86-93
8978305-6	1997	Our data suggest that the interaction between CRKL and the proline deletion mutant of BCR-ABL is an indirect interaction as CRKL does not interact directly with the proline deletion mutant of BCR-ABL in a gel overlay assay or in a yeast two-hybrid assay.	Proline	59-66	CRK like proto-oncogene, adaptor protein	Homo sapiens	124-128
8978305-2	1997	We have mapped the site of interaction of CRKL and BCR-ABL to the amino terminal SH3 domain of CRKL with a proline rich region in the C-terminus of ABL.	Proline	107-114	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	51-58
8978305-6	1997	Our data suggest that the interaction between CRKL and the proline deletion mutant of BCR-ABL is an indirect interaction as CRKL does not interact directly with the proline deletion mutant of BCR-ABL in a gel overlay assay or in a yeast two-hybrid assay.	Proline	165-172	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	86-93
8978305-2	1997	We have mapped the site of interaction of CRKL and BCR-ABL to the amino terminal SH3 domain of CRKL with a proline rich region in the C-terminus of ABL.	Proline	107-114	CRK like proto-oncogene, adaptor protein	Homo sapiens	95-99
8978305-2	1997	We have mapped the site of interaction of CRKL and BCR-ABL to the amino terminal SH3 domain of CRKL with a proline rich region in the C-terminus of ABL.	Proline	107-114	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	55-58
8988346-4	1997	At 24 h, the mice were sacrificed and the incorporation of [3H]proline into collagenase-digestible CDP labeling) and noncollagen (NCP labeling) protein in calvariae were determined by digestion with bacterial collagenase.	Proline	63-70	cut-like homeobox 1	Mus musculus	99-102
8978305-3	1997	The proline-rich region was mutated and the effect of this deletion on BCR-ABL transforming function was assayed.	Proline	4-11	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	71-78
8978305-5	1997	In cells expressing the proline deletion mutation of BCR-ABL, CRKL is still tyrosine phosphorylated and forms a complex with BCR-ABL as demonstrated by coimmunoprecipitation.	Proline	24-31	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	53-60
8978305-5	1997	In cells expressing the proline deletion mutation of BCR-ABL, CRKL is still tyrosine phosphorylated and forms a complex with BCR-ABL as demonstrated by coimmunoprecipitation.	Proline	24-31	CRK like proto-oncogene, adaptor protein	Homo sapiens	62-66
8978305-5	1997	In cells expressing the proline deletion mutation of BCR-ABL, CRKL is still tyrosine phosphorylated and forms a complex with BCR-ABL as demonstrated by coimmunoprecipitation.	Proline	24-31	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	125-132
8978305-6	1997	Our data suggest that the interaction between CRKL and the proline deletion mutant of BCR-ABL is an indirect interaction as CRKL does not interact directly with the proline deletion mutant of BCR-ABL in a gel overlay assay or in a yeast two-hybrid assay.	Proline	59-66	CRK like proto-oncogene, adaptor protein	Homo sapiens	46-50
9415380-3	1997	The S. pombe myo2+ head domain is 45% identical to myosin IIs from Saccharomyces cerevisiae and Homo sapiens and 40% identical to Drosophila melanogaster Structurally, myo2+ most closely resembles budding yeast MYO1, the tails of both myosin IIs containing a number of proline residues that are predicted to substantially disrupt the ability of these myosins to form coiled coils.	Proline	269-276	zipper	Drosophila melanogaster	13-17
9117086-2	1997	The degradation of bradykinin (BK) labelled with tritiated proline at positions 2 and 3 ([3H]-BK) was determined on the luminal surface of bovine tracheal epithelium, in supernatants obtained from incubations of the luminal tracheal surface, and in suspensions of isolated tracheal epithelial cells.	Proline	59-66	kininogen 1	Bos taurus	19-29
9117086-2	1997	The degradation of bradykinin (BK) labelled with tritiated proline at positions 2 and 3 ([3H]-BK) was determined on the luminal surface of bovine tracheal epithelium, in supernatants obtained from incubations of the luminal tracheal surface, and in suspensions of isolated tracheal epithelial cells.	Proline	59-66	kininogen 1	Bos taurus	31-33
9117086-6	1997	[1-7]-BK and [1-5]-BK were the major direct metabolites which were further degraded via [1-3]-BK and [2-3]-BK to proline.	Proline	113-120	kininogen 1	Bos taurus	6-8
9117086-6	1997	[1-7]-BK and [1-5]-BK were the major direct metabolites which were further degraded via [1-3]-BK and [2-3]-BK to proline.	Proline	113-120	kininogen 1	Bos taurus	19-21
9117086-6	1997	[1-7]-BK and [1-5]-BK were the major direct metabolites which were further degraded via [1-3]-BK and [2-3]-BK to proline.	Proline	113-120	kininogen 1	Bos taurus	19-21
9117086-6	1997	[1-7]-BK and [1-5]-BK were the major direct metabolites which were further degraded via [1-3]-BK and [2-3]-BK to proline.	Proline	113-120	kininogen 1	Bos taurus	19-21
9415380-3	1997	The S. pombe myo2+ head domain is 45% identical to myosin IIs from Saccharomyces cerevisiae and Homo sapiens and 40% identical to Drosophila melanogaster Structurally, myo2+ most closely resembles budding yeast MYO1, the tails of both myosin IIs containing a number of proline residues that are predicted to substantially disrupt the ability of these myosins to form coiled coils.	Proline	269-276	zipper	Drosophila melanogaster	168-172
10464642-4	1997	An exon 24 polymorphism of ATM, substituting arginine for proline was associated with breast cancer in these cases with an overall odds ratio of 4.5 (95% confidence interval, 1.2-20.5, nominal p = 0.02, 2-tail Fisher exact test).	Proline	58-65	ATM serine/threonine kinase	Homo sapiens	27-30
9524774-11	1997	A newly identified proline-rich domain of Gab-1 is responsible for the binding to the bidentate docking site in c-Met.	Proline	19-26	GRB2 associated binding protein 1	Homo sapiens	42-47
9524774-11	1997	A newly identified proline-rich domain of Gab-1 is responsible for the binding to the bidentate docking site in c-Met.	Proline	19-26	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	112-117
9076519-2	1997	We now report that the anti-Gal alpha(1,3)Gal antibodies and IB4 lectin also react with peptides encoded by mucin genes (MUC 1, 3, 4)-sequences known to be rich in serine, threonine and proline.	Proline	186-193	LOC100508689	Homo sapiens	108-113
9076519-2	1997	We now report that the anti-Gal alpha(1,3)Gal antibodies and IB4 lectin also react with peptides encoded by mucin genes (MUC 1, 3, 4)-sequences known to be rich in serine, threonine and proline.	Proline	186-193	mucin 1, cell surface associated	Homo sapiens	121-132
9622055-5	1997	In the carboxy-terminal region, mammalian Cbl forms share a proline-rich stretch, conserved tyrosine residues, and a leucine zipper.	Proline	60-67	Cbl proto-oncogene	Homo sapiens	42-45
9003491-3	1997	It was found that the variant with proline at this site was the more prevalent type of CTR among the Japanese population.	Proline	35-42	calcitonin receptor	Homo sapiens	87-90
9041517-3	1997	The overall structure of TRAP is conserved in all species; specifically, an amino-terminal A-domain similar to magnesium-binding domains of mammalian integrins; a thrombospondin-like sulfatide-binding domain similar to region II in Plasmodium circumsporozoite protein; an acidic asparagine/proline-rich repeat region; a trans-membrane domain and a short acidic cytoplasmic region with a highly conserved carboxy terminus.	Proline	290-297	TRAP	Homo sapiens	25-29
9230468-6	1997	The possibility of a beta-turn structure for the crucial Gly-Pro-Gly-Arg sequence has been confirmed by 2D NMR experiments.	Proline	61-64	amyloid beta precursor protein	Homo sapiens	19-25
8981360-10	1997	Rapid serine phosphorylation of p96 follows stimulation of cells with either CSF-1 or exogenous phospholipase C. Analysis of the murine cDNA encoding p96 reveals an amino-terminal domain with significant similarity to the amino-terminal domain of the Drosophila-disabled gene product and a carboxy-terminal domain containing proline-rich sequences characteristic of SH3 binding regions.	Proline	325-332	disabled 2, mitogen-responsive phosphoprotein	Mus musculus	32-35
8981360-10	1997	Rapid serine phosphorylation of p96 follows stimulation of cells with either CSF-1 or exogenous phospholipase C. Analysis of the murine cDNA encoding p96 reveals an amino-terminal domain with significant similarity to the amino-terminal domain of the Drosophila-disabled gene product and a carboxy-terminal domain containing proline-rich sequences characteristic of SH3 binding regions.	Proline	325-332	colony stimulating factor 1 (macrophage)	Mus musculus	77-82
8981360-10	1997	Rapid serine phosphorylation of p96 follows stimulation of cells with either CSF-1 or exogenous phospholipase C. Analysis of the murine cDNA encoding p96 reveals an amino-terminal domain with significant similarity to the amino-terminal domain of the Drosophila-disabled gene product and a carboxy-terminal domain containing proline-rich sequences characteristic of SH3 binding regions.	Proline	325-332	disabled 2, mitogen-responsive phosphoprotein	Mus musculus	150-153
9226475-1	1997	Dipeptidyl peptidase IV (DP IV, CD26) is a serine exoprotease which selectively cleaves the penultimate proline residue of polypeptides.	Proline	104-111	dipeptidylpeptidase 4	Rattus norvegicus	0-23
9226475-1	1997	Dipeptidyl peptidase IV (DP IV, CD26) is a serine exoprotease which selectively cleaves the penultimate proline residue of polypeptides.	Proline	104-111	dipeptidylpeptidase 4	Rattus norvegicus	25-30
9226475-1	1997	Dipeptidyl peptidase IV (DP IV, CD26) is a serine exoprotease which selectively cleaves the penultimate proline residue of polypeptides.	Proline	104-111	dipeptidylpeptidase 4	Rattus norvegicus	32-36
8990130-1	1997	A number of studies have implicated a proline-directed protein kinase, glycogen synthase kinase-3 (GSK-3) in the hyperphosphorylation of tau in Alzheimer"s disease (AD).	Proline	38-45	microtubule associated protein tau	Homo sapiens	137-140
9104733-1	1997	Cyclo (His-Pro) or CHP is a cyclic dipeptide that is known to elicit many biologic activities including inhibition of pituitary prolactin (PRL) secretion.	Proline	11-14	prolactin	Homo sapiens	128-137
9104733-1	1997	Cyclo (His-Pro) or CHP is a cyclic dipeptide that is known to elicit many biologic activities including inhibition of pituitary prolactin (PRL) secretion.	Proline	11-14	prolactin	Homo sapiens	139-142
9173241-0	1997	[Localization of the antigenic determinant of human pancreatic cholesterol esterase in proline-rich repeats].	Proline	87-94	carboxyl ester lipase	Homo sapiens	52-83
9606729-1	1997	NMR spectroscopy has been used to obtain structural information on the bioactive conformation of the nonapeptide hormone bradykinin (Arg-Pro-Pro-Gly-Ser-Pro-Phe-Arg, BK) bound to the Fab-fragment of an antibody that mimics the hormone binding site of the natural bradykinin B2-receptor.	Proline	137-140	kininogen 1	Homo sapiens	121-131
9361278-8	1997	The cytoplasmic domain of Sema VIb contains several proline-rich potential SH3 domain binding sites.	Proline	52-59	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	Mus musculus	26-34
9357058-4	1997	This study provides further evidence for an important role of proline 12 (numbering with respect to alpha-MSH) for binding and activity at the MC1 receptor.	Proline	62-69	proopiomelanocortin	Homo sapiens	100-109
9037161-0	1997	Mutations of cytochrome b6 in Chlamydomonas reinhardtii disclose the functional significance for a proline to leucine conversion by petB editing in maize and tobacco.	Proline	99-106	cytochrome b	Chlamydomonas reinhardtii	13-25
9216001-7	1997	Glutamate (3.2 mumol) or proline (10 mumol) also produced hippocampal damage; glutamate damage was primarily to the CA1 subfield, whereas proline damaged neurons throughout the entire hippocampal formation.	Proline	25-32	carbonic anhydrase 1	Mus musculus	116-119
9437709-2	1997	The primary structure of python substance P (Arg-Pro-Arg-Pro-Gln-Gln-Phe-Tyr-Gly-Leu- Met-NH2) shows one amino acid substitution (Phe8--&gt;Tyr) compared with chicken/alligator substance P and an additional substitution (Lys3--&gt;Arg) as compared with mammalian substance P.	Proline	49-52	tachykinin precursor 1	Homo sapiens	32-43
9437709-2	1997	The primary structure of python substance P (Arg-Pro-Arg-Pro-Gln-Gln-Phe-Tyr-Gly-Leu- Met-NH2) shows one amino acid substitution (Phe8--&gt;Tyr) compared with chicken/alligator substance P and an additional substitution (Lys3--&gt;Arg) as compared with mammalian substance P.	Proline	49-52	tachykinin precursor 1	Homo sapiens	177-188
9437709-2	1997	The primary structure of python substance P (Arg-Pro-Arg-Pro-Gln-Gln-Phe-Tyr-Gly-Leu- Met-NH2) shows one amino acid substitution (Phe8--&gt;Tyr) compared with chicken/alligator substance P and an additional substitution (Lys3--&gt;Arg) as compared with mammalian substance P.	Proline	49-52	tachykinin precursor 1	Homo sapiens	177-188
9606729-1	1997	NMR spectroscopy has been used to obtain structural information on the bioactive conformation of the nonapeptide hormone bradykinin (Arg-Pro-Pro-Gly-Ser-Pro-Phe-Arg, BK) bound to the Fab-fragment of an antibody that mimics the hormone binding site of the natural bradykinin B2-receptor.	Proline	137-140	FA complementation group B	Homo sapiens	183-186
9606729-1	1997	NMR spectroscopy has been used to obtain structural information on the bioactive conformation of the nonapeptide hormone bradykinin (Arg-Pro-Pro-Gly-Ser-Pro-Phe-Arg, BK) bound to the Fab-fragment of an antibody that mimics the hormone binding site of the natural bradykinin B2-receptor.	Proline	137-140	kininogen 1	Homo sapiens	263-273
9606729-1	1997	NMR spectroscopy has been used to obtain structural information on the bioactive conformation of the nonapeptide hormone bradykinin (Arg-Pro-Pro-Gly-Ser-Pro-Phe-Arg, BK) bound to the Fab-fragment of an antibody that mimics the hormone binding site of the natural bradykinin B2-receptor.	Proline	141-144	kininogen 1	Homo sapiens	121-131
9606729-1	1997	NMR spectroscopy has been used to obtain structural information on the bioactive conformation of the nonapeptide hormone bradykinin (Arg-Pro-Pro-Gly-Ser-Pro-Phe-Arg, BK) bound to the Fab-fragment of an antibody that mimics the hormone binding site of the natural bradykinin B2-receptor.	Proline	141-144	FA complementation group B	Homo sapiens	183-186
9274061-0	1997	Genetic approaches to biochemical questions: insights into the functional requirements of proline 185 in the active site of human galactose-1-phosphate uridylyltransferase.	Proline	90-97	galactose-1-phosphate uridylyltransferase	Homo sapiens	130-171
9606729-1	1997	NMR spectroscopy has been used to obtain structural information on the bioactive conformation of the nonapeptide hormone bradykinin (Arg-Pro-Pro-Gly-Ser-Pro-Phe-Arg, BK) bound to the Fab-fragment of an antibody that mimics the hormone binding site of the natural bradykinin B2-receptor.	Proline	141-144	kininogen 1	Homo sapiens	263-273
8953041-1	1996	The human Kv1.5 potassium channel (hKv1.5) contains proline-rich sequences identical to those that bind to Src homology 3 (SH3) domains.	Proline	52-59	potassium voltage-gated channel subfamily A member 5	Homo sapiens	10-15
9354272-6	1997	In RV Ch-1 the proline residue 309, reported to be critical for the trimerization of VP6, was replaced by leucine, but VP6 trimers were still observed.	Proline	15-22	SUN domain containing ossification factor	Homo sapiens	6-10
8953041-1	1996	The human Kv1.5 potassium channel (hKv1.5) contains proline-rich sequences identical to those that bind to Src homology 3 (SH3) domains.	Proline	52-59	potassium voltage-gated channel subfamily A member 5	Homo sapiens	35-41
8953041-1	1996	The human Kv1.5 potassium channel (hKv1.5) contains proline-rich sequences identical to those that bind to Src homology 3 (SH3) domains.	Proline	52-59	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	107-110
8953041-3	1996	This interaction was mediated by the proline-rich motif of hKv1.5 and the SH3 domain of Src.	Proline	37-44	potassium voltage-gated channel subfamily A member 5	Homo sapiens	59-65
8953041-3	1996	This interaction was mediated by the proline-rich motif of hKv1.5 and the SH3 domain of Src.	Proline	37-44	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	88-91
9003389-5	1996	We have identified the proline-directed residue Ser-162 of MBP as a major phosphorylation site for PITALRE.	Proline	23-30	myelin basic protein	Homo sapiens	59-62
8986805-5	1996	PRCC is ubiquitously expressed in normal adult and fetal tissues and encodes a putative protein of 491 aa with a relatively high content of prolines.	Proline	140-148	proline rich mitotic checkpoint control factor	Homo sapiens	0-4
8986812-4	1996	This region of the human p53 protein is localized between amino acids 61 and 94 (out of 393) and is noteworthy in that it contains five repeats of the sequence PXXP (where P represents proline and X any amino acid).	Proline	185-192	tumor protein p53	Homo sapiens	25-28
8986812-6	1996	A p53 cDNA deletion mutant (delta pro AE), which lacks this entire proline-rich domain (deleted for amino acids 62-91), was created and characterized for a variety of p53 functions.	Proline	67-74	tumor protein p53	Homo sapiens	2-5
8986812-8	1996	On the other hand, this deletion of the p53 proline-rich domain impairs p53"s ability to suppress tumor cell growth in culture.	Proline	44-51	transformation related protein 53, pseudogene	Mus musculus	40-43
8986812-8	1996	On the other hand, this deletion of the p53 proline-rich domain impairs p53"s ability to suppress tumor cell growth in culture.	Proline	44-51	transformation related protein 53, pseudogene	Mus musculus	72-75
8986812-12	1996	These data indicate that, in addition to the transcriptional activation domain, the p53 proline-rich domain plays a critical role in the transmission of antiproliferative signals down-stream of the p53 protein and may link p53 to a direct signal transduction pathway.	Proline	88-95	tumor protein p53	Homo sapiens	84-87
8986812-12	1996	These data indicate that, in addition to the transcriptional activation domain, the p53 proline-rich domain plays a critical role in the transmission of antiproliferative signals down-stream of the p53 protein and may link p53 to a direct signal transduction pathway.	Proline	88-95	tumor protein p53	Homo sapiens	198-201
8986812-12	1996	These data indicate that, in addition to the transcriptional activation domain, the p53 proline-rich domain plays a critical role in the transmission of antiproliferative signals down-stream of the p53 protein and may link p53 to a direct signal transduction pathway.	Proline	88-95	tumor protein p53	Homo sapiens	198-201
9581474-0	1997	Prolidase as a prodrug converting enzyme I. Synthesis of proline analogue of chlorambucil and its susceptibility to the action of prolidase.	Proline	57-64	peptidase D	Homo sapiens	0-9
9581474-0	1997	Prolidase as a prodrug converting enzyme I. Synthesis of proline analogue of chlorambucil and its susceptibility to the action of prolidase.	Proline	57-64	peptidase D	Homo sapiens	130-139
9581474-2	1997	The synthesis of proline analogue of chlorambucil (well known antineoplastic agent) conjugated through imido-bond (potential target for prolidase action) has been performed.	Proline	17-24	peptidase D	Homo sapiens	136-145
9003389-6	1996	In addition, our results suggest that one of the two MBP proline-directed threonine residues, Thr-97, is also selectively phosphorylated by PITALRE.	Proline	57-64	myelin basic protein	Homo sapiens	53-56
9003389-6	1996	In addition, our results suggest that one of the two MBP proline-directed threonine residues, Thr-97, is also selectively phosphorylated by PITALRE.	Proline	57-64	cyclin dependent kinase 9	Homo sapiens	140-147
9003389-7	1996	These data, together with analysis of different peptide substrates derived from sites on MBP that are phosphorylated by PITALRE, indicate that PITALRE is a Ser/Thr proline-directed kinase.	Proline	164-171	myelin basic protein	Homo sapiens	89-92
9003389-7	1996	These data, together with analysis of different peptide substrates derived from sites on MBP that are phosphorylated by PITALRE, indicate that PITALRE is a Ser/Thr proline-directed kinase.	Proline	164-171	cyclin dependent kinase 9	Homo sapiens	120-127
9003389-7	1996	These data, together with analysis of different peptide substrates derived from sites on MBP that are phosphorylated by PITALRE, indicate that PITALRE is a Ser/Thr proline-directed kinase.	Proline	164-171	cyclin dependent kinase 9	Homo sapiens	143-150
9003389-5	1996	We have identified the proline-directed residue Ser-162 of MBP as a major phosphorylation site for PITALRE.	Proline	23-30	cyclin dependent kinase 9	Homo sapiens	99-106
9003320-10	1996	The PDH gene was also significantly induced by exogenously applied proline.	Proline	67-74	proline dehydrogenase	Saccharomyces cerevisiae S288C	4-7
9003320-11	1996	The induction of PDH by proline, however, was inhibited by salt stress.	Proline	24-31	proline dehydrogenase	Saccharomyces cerevisiae S288C	17-20
9003320-3	1996	In order to understand the mechanisms involved in regulating the levels of proline, we cloned and characterized a proline dehydrogenase (PDH) cDNA from Arabidopsis thaliana (AtPDH).	Proline	75-82	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	114-135
9003320-3	1996	In order to understand the mechanisms involved in regulating the levels of proline, we cloned and characterized a proline dehydrogenase (PDH) cDNA from Arabidopsis thaliana (AtPDH).	Proline	75-82	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	137-140
8940134-5	1996	When wild-type PTP1B is expressed in 3Y1-v-crk cells, p130(Cas) shows substantial dephosphorylation, whereas the PTP1B proline mutant does not have this effect.	Proline	119-126	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	113-118
9003320-3	1996	In order to understand the mechanisms involved in regulating the levels of proline, we cloned and characterized a proline dehydrogenase (PDH) cDNA from Arabidopsis thaliana (AtPDH).	Proline	75-82	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	174-179
9003320-8	1996	The results demonstrated that the removal of free proline during the recovery from salinity or dehydration stress involves an induction of the PDH gene while the activity of P5CS declines.	Proline	50-57	proline dehydrogenase	Saccharomyces cerevisiae S288C	143-146
9003320-9	1996	The reciprocal regulation of P5CS and PDH genes appears to be a key mechanism in the control of the levels of proline during and after osmotic stress.	Proline	110-117	proline dehydrogenase	Saccharomyces cerevisiae S288C	38-41
8940160-3	1996	Both the human and mouse zyxin proteins display a collection of proline-rich sequences as well as three copies of the LIM domain, a zinc finger domain found in many signaling molecules.	Proline	64-71	zyxin	Mus musculus	25-30
8940134-0	1996	Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas).	Proline	22-29	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	45-76
8940134-0	1996	Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas).	Proline	22-29	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	109-113
8940134-0	1996	Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas).	Proline	22-29	BCAR1 scaffold protein, Cas family member	Homo sapiens	114-117
8940134-7	1996	These results suggest that the proline-rich domain between amino acids 301 and 315 in PTP1B binds Src homology 3-containing proteins and that p130(Cas) may be a physiological target of this phosphatase in cells.	Proline	31-38	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	86-91
8940134-2	1996	The C terminus of PTP1B contains two proline-rich regions which conform to the canonical class II Src homology 3 domain binding motif, Pro-X-X-Pro-X-Arg.	Proline	37-44	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	18-23
8940134-7	1996	These results suggest that the proline-rich domain between amino acids 301 and 315 in PTP1B binds Src homology 3-containing proteins and that p130(Cas) may be a physiological target of this phosphatase in cells.	Proline	31-38	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	142-146
8940134-4	1996	The interaction of PTP1B and p130(Cas) is independent of tyrosine phosphorylation but can be disrupted by replacing two critical proline residues in the proline-rich domain of PTP1B between amino acids 301 and 315.	Proline	129-136	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	19-24
8940134-4	1996	The interaction of PTP1B and p130(Cas) is independent of tyrosine phosphorylation but can be disrupted by replacing two critical proline residues in the proline-rich domain of PTP1B between amino acids 301 and 315.	Proline	129-136	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	29-33
8940134-4	1996	The interaction of PTP1B and p130(Cas) is independent of tyrosine phosphorylation but can be disrupted by replacing two critical proline residues in the proline-rich domain of PTP1B between amino acids 301 and 315.	Proline	129-136	BCAR1 scaffold protein, Cas family member	Homo sapiens	34-37
8940134-4	1996	The interaction of PTP1B and p130(Cas) is independent of tyrosine phosphorylation but can be disrupted by replacing two critical proline residues in the proline-rich domain of PTP1B between amino acids 301 and 315.	Proline	129-136	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	176-181
8940134-4	1996	The interaction of PTP1B and p130(Cas) is independent of tyrosine phosphorylation but can be disrupted by replacing two critical proline residues in the proline-rich domain of PTP1B between amino acids 301 and 315.	Proline	153-160	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	19-24
8940134-4	1996	The interaction of PTP1B and p130(Cas) is independent of tyrosine phosphorylation but can be disrupted by replacing two critical proline residues in the proline-rich domain of PTP1B between amino acids 301 and 315.	Proline	153-160	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	29-33
8940134-7	1996	These results suggest that the proline-rich domain between amino acids 301 and 315 in PTP1B binds Src homology 3-containing proteins and that p130(Cas) may be a physiological target of this phosphatase in cells.	Proline	31-38	BCAR1 scaffold protein, Cas family member	Homo sapiens	147-150
8940134-4	1996	The interaction of PTP1B and p130(Cas) is independent of tyrosine phosphorylation but can be disrupted by replacing two critical proline residues in the proline-rich domain of PTP1B between amino acids 301 and 315.	Proline	153-160	BCAR1 scaffold protein, Cas family member	Homo sapiens	34-37
8940134-4	1996	The interaction of PTP1B and p130(Cas) is independent of tyrosine phosphorylation but can be disrupted by replacing two critical proline residues in the proline-rich domain of PTP1B between amino acids 301 and 315.	Proline	153-160	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	176-181
8980130-0	1996	VASP interaction with vinculin: a recurring theme of interactions with proline-rich motifs.	Proline	71-78	vasodilator stimulated phosphoprotein	Homo sapiens	0-4
8940134-5	1996	When wild-type PTP1B is expressed in 3Y1-v-crk cells, p130(Cas) shows substantial dephosphorylation, whereas the PTP1B proline mutant does not have this effect.	Proline	119-126	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	15-20
8961927-0	1996	Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.	Proline	101-108	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	88-91
8961927-0	1996	Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.	Proline	101-108	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	134-137
8961927-2	1996	The solution structure complex of the SH3 domain with a proline-rich peptide mimic of the binding site on the p85 subunit is described.	Proline	56-63	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	110-113
8980130-3	1996	Competition experiments with a vinculin-derived peptide showed that a proline-rich motif, located in the hinge region that connects vinculin"s head and tail domains, is involved in VASP binding.	Proline	70-77	vinculin	Homo sapiens	132-140
8980130-0	1996	VASP interaction with vinculin: a recurring theme of interactions with proline-rich motifs.	Proline	71-78	vinculin	Homo sapiens	22-30
8980130-3	1996	Competition experiments with a vinculin-derived peptide showed that a proline-rich motif, located in the hinge region that connects vinculin"s head and tail domains, is involved in VASP binding.	Proline	70-77	vasodilator stimulated phosphoprotein	Homo sapiens	181-185
8980130-3	1996	Competition experiments with a vinculin-derived peptide showed that a proline-rich motif, located in the hinge region that connects vinculin"s head and tail domains, is involved in VASP binding.	Proline	70-77	vinculin	Homo sapiens	31-39
8957040-8	1996	Gene expression of ornithine aminotransferase, a proline synthetic enzyme, was increased from day 1, paralleling increased collagen synthesis.	Proline	49-56	ornithine aminotransferase	Rattus norvegicus	19-45
8980645-5	1996	Furthermore, proline isomerization is part of the rate-limiting step of refolding even in the presence of GroEL, and it is very noteworthy that prolyl isomerase will influence the refolding of HCA II in the presence of GroEL.	Proline	13-20	heat shock protein family D (Hsp60) member 1	Homo sapiens	106-111
9038605-4	1996	In 4 cases, the mutations lead to distinct changes in the primary or secondary structure of the protein (cysteine--&gt;tyrosine, proline--&gt;leucine) and were associated with marked accumulation of p53 protein.	Proline	129-136	tumor protein p53	Homo sapiens	199-202
9006096-6	1996	A hydrophobic domain of 14 residues followed by a proline-rich domain, both located in the N-terminal region, showed 71% homology with the transmembrane domain of the precursor for the interleukin-6 receptor and a conserved consensus sequence found in the cytokine/growth factor/prolactin receptor superfamily respectively.	Proline	50-57	interleukin 6 receptor	Rattus norvegicus	185-207
8922361-1	1996	Insulin lispro [Lys (B28), Pro (B29) human insulin] is a rapidly absorbed analog that has diminished tendency to self-associate.	Proline	27-30	insulin	Homo sapiens	0-7
8922361-1	1996	Insulin lispro [Lys (B28), Pro (B29) human insulin] is a rapidly absorbed analog that has diminished tendency to self-associate.	Proline	27-30	CD79b molecule	Homo sapiens	32-35
8922361-1	1996	Insulin lispro [Lys (B28), Pro (B29) human insulin] is a rapidly absorbed analog that has diminished tendency to self-associate.	Proline	27-30	insulin	Homo sapiens	43-50
8939821-5	1996	RB97D contains two copies of a well-characterized RNA binding domain, the RNA recognition motif, followed by a proline-glutamine rich domain.	Proline	111-118	Ribonuclear protein at 97D	Drosophila melanogaster	0-5
9115846-4	1996	Vav has a leucine-rich region, a leucine-zipper, a calponin homology domain, an acidic domain, a Dbl-homology domain, a pleckstrin homology domain, a cysteine-rich domain, two Src homology 3 domains, with a proline-rich region in the amino-SH3 domain, and finally an Src homology 2 domain.	Proline	207-214	vav guanine nucleotide exchange factor 1	Homo sapiens	0-3
8972867-3	1996	We report the isolation of the PAT1 gene (for protein associated with topoisomerase II), which encodes a novel 90 kDa proline- and glutamine-rich protein that interacts with a highly conserved, leucine-rich region of topoisomerase II in vivo.	Proline	118-125	Pat1p	Saccharomyces cerevisiae S288C	31-35
9120678-9	1996	This mutation in codon 374 of exon 5 of the 11 beta-HSD2 gene creates an inframe premature stop (TGA) and, as such, results in a truncated 11 beta-HSD2 protein lacking the carboxyl-terminal proline-rich 32 amino acids.	Proline	190-197	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	44-56
9120678-9	1996	This mutation in codon 374 of exon 5 of the 11 beta-HSD2 gene creates an inframe premature stop (TGA) and, as such, results in a truncated 11 beta-HSD2 protein lacking the carboxyl-terminal proline-rich 32 amino acids.	Proline	190-197	T-box transcription factor 1	Homo sapiens	97-100
9120678-9	1996	This mutation in codon 374 of exon 5 of the 11 beta-HSD2 gene creates an inframe premature stop (TGA) and, as such, results in a truncated 11 beta-HSD2 protein lacking the carboxyl-terminal proline-rich 32 amino acids.	Proline	190-197	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	139-151
8954792-5	1996	Type II arginase may be an important part of the arginine regulatory system affecting nitric oxide synthase, arginine decarboxylase, kyotorphin synthase, and arginine-glycine transaminase activities and polyamine and proline biosynthesis.	Proline	217-224	arginase 2	Homo sapiens	0-16
8943400-5	1996	GMP1 consisted of four short consensus repeats (SCRs), regions corresponding to the human serine/threonine/proline-rich C (STP(C)) domain and a human region of unknown significance, a hydrophobic region presumed to be a transmembrane domain, and a cytoplasmic region.	Proline	107-114	small ubiquitin like modifier 1	Homo sapiens	0-4
8943355-6	1996	Nrd1 has hallmarks of a heterogeneous nuclear ribonucleoprotein, including an RNA recognition motif, a region rich in RE and RS dipeptides, and a proline- and glutamine-rich domain.	Proline	146-153	Nrd1 complex RNA-binding subunit	Saccharomyces cerevisiae S288C	0-4
8971722-0	1996	The putA gene of Agrobacterium tumefaciens is transcriptionally activated in response to proline by an Lrp-like protein and is not autoregulated.	Proline	89-96	putA	Agrobacterium tumefaciens	4-8
8971722-1	1996	The Agrobacterium tumefaciens putA gene, which encodes proline dehydrogenase, is transcriptionally induced by exogenous proline.	Proline	55-62	putA	Agrobacterium tumefaciens	30-34
8971722-2	1996	In contrast to the putA genes of enteric bacteria, the A. tumefaciens putA gene is not regulated by the PutA protein, as the putA promoter remained strongly proline inducible in strains lacking PutA.	Proline	157-164	putA	Agrobacterium tumefaciens	70-74
8971722-2	1996	In contrast to the putA genes of enteric bacteria, the A. tumefaciens putA gene is not regulated by the PutA protein, as the putA promoter remained strongly proline inducible in strains lacking PutA.	Proline	157-164	putA	Agrobacterium tumefaciens	70-74
8971722-4	1996	However, this mutation is predicted to increase the cytoplasmic concentration of proline, and this alone probably accounts for its effects on putA expression.	Proline	81-88	putA	Agrobacterium tumefaciens	142-146
8971722-7	1996	Disruption of this ORF, designated putR, abolished induction of the putA promoter by proline or valine.	Proline	85-92	putA	Agrobacterium tumefaciens	68-72
8939900-4	1996	TGF-beta induces the proline-rich transactivation domain of specific CTF/NF-I family members, such as CTF-1, whereas TNF-alpha represses both the uninduced as well as the TGF-beta-induced CTF-1 transcriptional activity.	Proline	21-28	transforming growth factor, beta 1	Mus musculus	0-8
8940062-8	1996	The protease-sensitive sites were located within a 50-residue stretch that contained most of the nonconserved and proline residues of Bcl-2(1-203).	Proline	114-121	B cell leukemia/lymphoma 2	Mus musculus	134-139
8940068-4	1996	These effects of MAPK are transmitted through a specific serine residue (Ser-303) located in a proline-rich sequence within the transcriptional regulatory domain of human HSF-1.	Proline	95-102	heat shock transcription factor 1	Homo sapiens	171-176
8939900-4	1996	TGF-beta induces the proline-rich transactivation domain of specific CTF/NF-I family members, such as CTF-1, whereas TNF-alpha represses both the uninduced as well as the TGF-beta-induced CTF-1 transcriptional activity.	Proline	21-28	cardiotrophin 1	Mus musculus	188-193
8939900-4	1996	TGF-beta induces the proline-rich transactivation domain of specific CTF/NF-I family members, such as CTF-1, whereas TNF-alpha represses both the uninduced as well as the TGF-beta-induced CTF-1 transcriptional activity.	Proline	21-28	nuclear factor I/X	Mus musculus	69-72
8939900-6	1996	The previously identified TGF-beta-responsive domain in the proline-rich transcriptional activation sequence of CTF-1 mediates both transcriptional induction and repression by the two growth factors.	Proline	60-67	transforming growth factor, beta 1	Mus musculus	26-34
8939900-6	1996	The previously identified TGF-beta-responsive domain in the proline-rich transcriptional activation sequence of CTF-1 mediates both transcriptional induction and repression by the two growth factors.	Proline	60-67	cardiotrophin 1	Mus musculus	112-117
8939900-4	1996	TGF-beta induces the proline-rich transactivation domain of specific CTF/NF-I family members, such as CTF-1, whereas TNF-alpha represses both the uninduced as well as the TGF-beta-induced CTF-1 transcriptional activity.	Proline	21-28	cardiotrophin 1	Mus musculus	102-107
8950985-4	1996	In addition, the sensitivity of H-Ras to GRF was abolished when residues 130-139 were replaced by proline-aspartic acid-glutamine, whereas substitution of the entire loop 8 (residues 123-130 replaced by leucine-isoleucine-arginine) had no effect on the stimulation of guanine nucleotide release by GRF.	Proline	98-105	HRas proto-oncogene, GTPase	Homo sapiens	32-37
8950985-4	1996	In addition, the sensitivity of H-Ras to GRF was abolished when residues 130-139 were replaced by proline-aspartic acid-glutamine, whereas substitution of the entire loop 8 (residues 123-130 replaced by leucine-isoleucine-arginine) had no effect on the stimulation of guanine nucleotide release by GRF.	Proline	98-105	growth hormone releasing hormone	Homo sapiens	41-44
8955343-4	1996	This genetic screen clearly indicates that the interaction between SH3 domain of Fyn and the proline-rich region (residues: 80-104) of PI-3 kinase is highly specific.	Proline	93-100	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	81-84
8906793-3	1996	A newly identified proline-rich domain of Gab1 is responsible for the binding of this protein to the tyrosine-phosphorylated bidentate docking site in c-Met.	Proline	19-26	GRB2 associated binding protein 1	Homo sapiens	42-46
8955343-5	1996	Mutational analysis revealed that amino acid residues Asp92, Tyr93, Arg96 and Thr97 of the SH3 domain of Fyn are essential for interacting with the proline-rich peptide of PI-3 kinase.	Proline	148-155	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	105-108
8910553-7	1996	Mutation of proline 6 in RIIalpha reduced binding for four AKAPs (Ht31, MAP2, AKAP79, and AKAP95) from 2.3 to 20-fold (n = 4) whereas introduction of an additional proline at position 6 in RIIbeta increased or conferred binding toward these anchoring proteins.	Proline	12-19	microtubule associated protein 2	Homo sapiens	72-76
8910553-7	1996	Mutation of proline 6 in RIIalpha reduced binding for four AKAPs (Ht31, MAP2, AKAP79, and AKAP95) from 2.3 to 20-fold (n = 4) whereas introduction of an additional proline at position 6 in RIIbeta increased or conferred binding toward these anchoring proteins.	Proline	12-19	A-kinase anchoring protein 8	Homo sapiens	90-96
8910553-7	1996	Mutation of proline 6 in RIIalpha reduced binding for four AKAPs (Ht31, MAP2, AKAP79, and AKAP95) from 2.3 to 20-fold (n = 4) whereas introduction of an additional proline at position 6 in RIIbeta increased or conferred binding toward these anchoring proteins.	Proline	12-19	protein kinase cAMP-dependent type II regulatory subunit beta	Homo sapiens	189-196
8906793-3	1996	A newly identified proline-rich domain of Gab1 is responsible for the binding of this protein to the tyrosine-phosphorylated bidentate docking site in c-Met.	Proline	19-26	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	151-156
8944764-0	1996	Phosphorylation and dephosphorylation in the proline-rich C-terminal domain of microtubule-associated protein 2.	Proline	45-52	microtubule-associated protein 2	Rattus norvegicus	79-111
8939605-8	1996	These residues are present in the central proline-rich (CH1) region and are conserved in all isoforms of Shc.	Proline	42-49	SHC adaptor protein 1	Homo sapiens	105-108
8944764-1	1996	The C-terminal domain of microtubule-associated protein 2 (MAP2) contains a proline-rich region and the tubulin-binding domain.	Proline	76-83	microtubule-associated protein 2	Rattus norvegicus	25-57
8944764-1	1996	The C-terminal domain of microtubule-associated protein 2 (MAP2) contains a proline-rich region and the tubulin-binding domain.	Proline	76-83	microtubule-associated protein 2	Rattus norvegicus	59-63
8944764-5	1996	This sequence is present in the proline-rich region of MAP2 and is phosphorylated in vitro by at least three different proline-directed protein kinases: p42mpk, p34cdc2, and GSK3 (glycogen-synthase kinase 3) alpha/beta.	Proline	32-39	microtubule-associated protein 2	Rattus norvegicus	55-59
8946918-3	1996	We show here that two specific proline-directed serine motifs are important for function of the regulatory domain: Mutation of these serines to alanine derepresses HSF1 activity at control temperature, and mutation to glutamic acid, mimicking a phosphorylated serine, results in normal repression at control temperature and normal heat shock inducibility.	Proline	31-38	heat shock transcription factor 1	Homo sapiens	164-168
8944764-5	1996	This sequence is present in the proline-rich region of MAP2 and is phosphorylated in vitro by at least three different proline-directed protein kinases: p42mpk, p34cdc2, and GSK3 (glycogen-synthase kinase 3) alpha/beta.	Proline	32-39	glycogen synthase kinase 3 alpha	Rattus norvegicus	180-213
8910365-9	1996	Furthermore, in the presence of inhibitors of p38 kinase, the proline-directed phosphorylation of cPLA2 was completely blocked in platelets stimulated with the thrombin receptor agonist peptide SFLLRN and was suppressed during the early (up to 2 min) phase of platelet stimulation caused by thrombin.	Proline	62-69	mitogen-activated protein kinase 14	Homo sapiens	46-49
8936461-9	1996	Nucleotide sequencing of the polymerase chain reaction-amplified beta-globin gene revealed a heterozygous single base pair T-->C mutation at codon 75, which changes the normal CTG codon for leucine to a CCG codon for proline.	Proline	217-224	hemoglobin subunit beta	Homo sapiens	65-76
8910365-9	1996	Furthermore, in the presence of inhibitors of p38 kinase, the proline-directed phosphorylation of cPLA2 was completely blocked in platelets stimulated with the thrombin receptor agonist peptide SFLLRN and was suppressed during the early (up to 2 min) phase of platelet stimulation caused by thrombin.	Proline	62-69	phospholipase A2 group IVA	Homo sapiens	98-103
8910365-9	1996	Furthermore, in the presence of inhibitors of p38 kinase, the proline-directed phosphorylation of cPLA2 was completely blocked in platelets stimulated with the thrombin receptor agonist peptide SFLLRN and was suppressed during the early (up to 2 min) phase of platelet stimulation caused by thrombin.	Proline	62-69	coagulation factor II, thrombin	Homo sapiens	160-168
8910365-9	1996	Furthermore, in the presence of inhibitors of p38 kinase, the proline-directed phosphorylation of cPLA2 was completely blocked in platelets stimulated with the thrombin receptor agonist peptide SFLLRN and was suppressed during the early (up to 2 min) phase of platelet stimulation caused by thrombin.	Proline	62-69	coagulation factor II, thrombin	Homo sapiens	291-299
8910365-10	1996	Unexpectedly, we found that prevention of proline-directed phosphorylation of cPLA2 in stimulated platelets did not attenuate its ability to release arachidonic acid from platelet phospholipids.	Proline	42-49	phospholipase A2 group IVA	Homo sapiens	78-83
8910365-11	1996	We conclude that: 1) cPLA2 is a physiological target of p38 kinase; 2) p38 kinase is involved in the early phosphorylation of cPLA2 in stimulated platelets; and 3) proline-directed phosphorylation of cPLA2 is not required for its receptor-mediated activation.	Proline	164-171	phospholipase A2 group IVA	Homo sapiens	21-26
8910365-11	1996	We conclude that: 1) cPLA2 is a physiological target of p38 kinase; 2) p38 kinase is involved in the early phosphorylation of cPLA2 in stimulated platelets; and 3) proline-directed phosphorylation of cPLA2 is not required for its receptor-mediated activation.	Proline	164-171	mitogen-activated protein kinase 14	Homo sapiens	56-59
8910365-11	1996	We conclude that: 1) cPLA2 is a physiological target of p38 kinase; 2) p38 kinase is involved in the early phosphorylation of cPLA2 in stimulated platelets; and 3) proline-directed phosphorylation of cPLA2 is not required for its receptor-mediated activation.	Proline	164-171	mitogen-activated protein kinase 14	Homo sapiens	71-74
8910365-11	1996	We conclude that: 1) cPLA2 is a physiological target of p38 kinase; 2) p38 kinase is involved in the early phosphorylation of cPLA2 in stimulated platelets; and 3) proline-directed phosphorylation of cPLA2 is not required for its receptor-mediated activation.	Proline	164-171	phospholipase A2 group IVA	Homo sapiens	126-131
8910365-11	1996	We conclude that: 1) cPLA2 is a physiological target of p38 kinase; 2) p38 kinase is involved in the early phosphorylation of cPLA2 in stimulated platelets; and 3) proline-directed phosphorylation of cPLA2 is not required for its receptor-mediated activation.	Proline	164-171	phospholipase A2 group IVA	Homo sapiens	126-131
8937992-6	1996	A serine/proline rich site, which can be phosphorylated by kinases in developing muscle tissues, was identified near the amino terminus of titin.	Proline	9-16	titin	Homo sapiens	139-144
8915770-7	1996	TGF-beta 1 also enhanced the release of 3H from [3H]proline labeled bones and the mobilization of Ca2+ and Pi from unlabeled bones, as well as the release of lysosomal enzymes (beta-N-acetylglucosaminidase).	Proline	52-59	transforming growth factor, beta 1	Mus musculus	0-10
8917699-2	1996	A primary murine mesothelial cell line (D9) spontaneously acquired a point mutation at codon 135 in exon 5 of the p53 gene, resulting in substitution of alanine for proline; early passage D9 cells expressed wild-type p53.	Proline	165-172	transformation related protein 53, pseudogene	Mus musculus	114-117
8920860-4	1996	We show that at least part of Fc epsilon R1-induced Cbl tyrosine phosphorylation is mediated by the Syk tyrosine kinase, and that the Syk-dependent tyrosine phosphorylation of Cbl occurs mainly distal to the Cbl proline-rich region within the COOH-terminal 250 amino acids.	Proline	212-219	Cbl proto-oncogene	Rattus norvegicus	52-55
8920860-4	1996	We show that at least part of Fc epsilon R1-induced Cbl tyrosine phosphorylation is mediated by the Syk tyrosine kinase, and that the Syk-dependent tyrosine phosphorylation of Cbl occurs mainly distal to the Cbl proline-rich region within the COOH-terminal 250 amino acids.	Proline	212-219	spleen associated tyrosine kinase	Rattus norvegicus	134-137
8920860-4	1996	We show that at least part of Fc epsilon R1-induced Cbl tyrosine phosphorylation is mediated by the Syk tyrosine kinase, and that the Syk-dependent tyrosine phosphorylation of Cbl occurs mainly distal to the Cbl proline-rich region within the COOH-terminal 250 amino acids.	Proline	212-219	Cbl proto-oncogene	Rattus norvegicus	176-179
8920860-4	1996	We show that at least part of Fc epsilon R1-induced Cbl tyrosine phosphorylation is mediated by the Syk tyrosine kinase, and that the Syk-dependent tyrosine phosphorylation of Cbl occurs mainly distal to the Cbl proline-rich region within the COOH-terminal 250 amino acids.	Proline	212-219	Cbl proto-oncogene	Rattus norvegicus	176-179
8920860-5	1996	Furthermore, we show by coprecipitation that Cbl is present in a complex with Syk before receptor engagement, that the proline-rich region of Cbl and a region of Syk comprised of the two SH2 domains and intradomain linker are required for formation of the complex, and that little or no tyrosine-phosphorylated Cbl is detected in complex with Syk.	Proline	119-126	Cbl proto-oncogene	Rattus norvegicus	45-48
8920860-5	1996	Furthermore, we show by coprecipitation that Cbl is present in a complex with Syk before receptor engagement, that the proline-rich region of Cbl and a region of Syk comprised of the two SH2 domains and intradomain linker are required for formation of the complex, and that little or no tyrosine-phosphorylated Cbl is detected in complex with Syk.	Proline	119-126	spleen associated tyrosine kinase	Rattus norvegicus	78-81
8920860-5	1996	Furthermore, we show by coprecipitation that Cbl is present in a complex with Syk before receptor engagement, that the proline-rich region of Cbl and a region of Syk comprised of the two SH2 domains and intradomain linker are required for formation of the complex, and that little or no tyrosine-phosphorylated Cbl is detected in complex with Syk.	Proline	119-126	Cbl proto-oncogene	Rattus norvegicus	142-145
8920860-5	1996	Furthermore, we show by coprecipitation that Cbl is present in a complex with Syk before receptor engagement, that the proline-rich region of Cbl and a region of Syk comprised of the two SH2 domains and intradomain linker are required for formation of the complex, and that little or no tyrosine-phosphorylated Cbl is detected in complex with Syk.	Proline	119-126	Cbl proto-oncogene	Rattus norvegicus	142-145
8988856-0	1996	PR-39, a proline-rich peptide antibiotic from pig, and FALL-39, a tentative human counterpart.	Proline	9-16	antibacterial protein PR-39	Sus scrofa	0-5
9019712-2	1996	Tritiated L-proline incorporation into collagen was significantly stimulated by insulin-like growth factor-I in a time- and concentration-dependent manner.	Proline	10-19	insulin like growth factor 1	Homo sapiens	80-108
9019712-6	1996	The insulin-like growth factor-I-stimulated L-proline incorporation was inhibited by one of its binding proteins, insulin-like growth factor binding protein-4, in a concentration-dependent manner.	Proline	44-53	insulin like growth factor binding protein 4	Homo sapiens	114-158
8857542-9	1996	This involves a cyclophilin-mediated modification of R/G opsin, possibly involving proline isomerization.	Proline	83-90	neither inactivation nor afterpotential E	Drosophila melanogaster	57-62
8824292-8	1996	Additionally, we used truncation mutations of p120(cbl) to map the p120(cbl)-Grb2 interaction to amino acids 481-528 of p120(cbl); this interaction is stronger in longer constructs that include additional proline-rich motifs.	Proline	205-212	catenin delta 1	Homo sapiens	67-71
8900201-6	1996	However, CPP32 processes pro-Mch2alpha at three aspartate processing sites (Asp23, Asp179, and Asp193) to produce the large (p18) and small (p11) subunits of the mature Mch2alpha enzyme.	Proline	15-18	caspase 3	Homo sapiens	9-14
8900201-6	1996	However, CPP32 processes pro-Mch2alpha at three aspartate processing sites (Asp23, Asp179, and Asp193) to produce the large (p18) and small (p11) subunits of the mature Mch2alpha enzyme.	Proline	15-18	H3 histone pseudogene 12	Homo sapiens	125-128
8900201-6	1996	However, CPP32 processes pro-Mch2alpha at three aspartate processing sites (Asp23, Asp179, and Asp193) to produce the large (p18) and small (p11) subunits of the mature Mch2alpha enzyme.	Proline	15-18	endonuclease, poly(U) specific	Homo sapiens	141-144
8824195-7	1996	Both ZO-1 and ZO-2 have proline-rich C-terminal regions that are not homologous to other MAGUK family members.	Proline	24-31	tight junction protein 1	Canis lupus familiaris	5-18
8824201-6	1996	We show that Nck binds to PAK1 through its second Src homology 3 (SH3) domain, while PAK1 interacts with Nck via the first proline-rich SH3 binding motif at its amino terminus.	Proline	123-130	p21 (RAC1) activated kinase 1	Mus musculus	85-89
8824201-6	1996	We show that Nck binds to PAK1 through its second Src homology 3 (SH3) domain, while PAK1 interacts with Nck via the first proline-rich SH3 binding motif at its amino terminus.	Proline	123-130	non-catalytic region of tyrosine kinase adaptor protein 1	Mus musculus	105-108
8824292-8	1996	Additionally, we used truncation mutations of p120(cbl) to map the p120(cbl)-Grb2 interaction to amino acids 481-528 of p120(cbl); this interaction is stronger in longer constructs that include additional proline-rich motifs.	Proline	205-212	growth factor receptor bound protein 2	Homo sapiens	77-81
8824292-8	1996	Additionally, we used truncation mutations of p120(cbl) to map the p120(cbl)-Grb2 interaction to amino acids 481-528 of p120(cbl); this interaction is stronger in longer constructs that include additional proline-rich motifs.	Proline	205-212	catenin delta 1	Homo sapiens	67-71
8861907-3	1996	A conserved domain targets Mena to localized proteins containing a specific proline-rich motif.	Proline	76-83	ENAH actin regulator	Mus musculus	27-31
8915894-0	1996	Functional characterization of NCAM fibronectin type III domains: demonstration of modulatory effects of the proline-rich sequence encoded by alternatively spliced exons a and AAG.	Proline	109-116	neural cell adhesion molecule 1	Rattus norvegicus	31-35
8895525-3	1996	By deletion analysis, the transactivation domains of HOX-11 have been mapped to three amino acid stretches in the homeoprotein, the glycine-proline-rich region at the amino terminus, the homeodomain and the glutamine-rich region at the carboxyl terminus.	Proline	140-147	T cell leukemia homeobox 1	Homo sapiens	53-59
8895526-8	1996	Activation of syndecan-1 by WT1 is dependent on an intact zinc-finger region as well as a 179 amino acid proline-rich region in the amino terminus of the protein.	Proline	105-112	syndecan 1	Mus musculus	14-24
8895526-8	1996	Activation of syndecan-1 by WT1 is dependent on an intact zinc-finger region as well as a 179 amino acid proline-rich region in the amino terminus of the protein.	Proline	105-112	WT1 transcription factor	Mus musculus	28-31
8915894-8	1996	Thus, our data indicate that the NCAM-F3 domain are involved in cell-cell adhesion, and that insertion of the proline-rich sequence has a modulatory effect on NCAM-F3 domain functions.	Proline	110-117	neural cell adhesion molecule 1	Rattus norvegicus	159-163
8912692-0	1996	Interaction of aspartic acid-104 and proline-287 with the active site of m-calpain.	Proline	37-44	calpain 2	Homo sapiens	73-82
8912808-5	1996	At relatively low concentrations (30 pmol/1 to 30 nmol/l), PGE2 stimulated an increase in the incorporation of [3H]proline into collagenase digestible protein (CDP) (P &lt; 0.01, n = 5) whereas at high levels (300 nmol/l to 3 micromol/l) of the eicosanoid, incorporation diminished precipitously.	Proline	115-122	cut like homeobox 1	Homo sapiens	128-158
8855938-3	1996	The three independently determined thrombin/G17 psi complexes in the crystal asymmetric unit reveal novel interactions for the P2" and P3" residues-Pro-18f and Arg-19f, respectively-on the carboxyl-terminal side of the scissile bond and confirm previously observed interactions of the P1 (Arg-16f) through P10 (Asp-7f) positions on the amino-terminal side.	Proline	148-151	coagulation factor II, thrombin	Bos taurus	35-43
8798720-5	1996	Tryptic peptide mapping of ASF/SF2 revealed that three of the phosphopeptides from full-length ASF/SF2 phosphorylated in vitro contain consecutive phosphoserine-arginine residues or phosphoserine-proline residues.	Proline	196-203	serine and arginine rich splicing factor 1	Homo sapiens	27-34
8798720-5	1996	Tryptic peptide mapping of ASF/SF2 revealed that three of the phosphopeptides from full-length ASF/SF2 phosphorylated in vitro contain consecutive phosphoserine-arginine residues or phosphoserine-proline residues.	Proline	196-203	serine and arginine rich splicing factor 1	Homo sapiens	95-102
11667614-2	1996	Reduction, protection, and deprotection of these heterocyclic compounds afforded proline derivatives 6 and 25 which contain all the structural elements of alpha-kainic acid (1) except the C-2 acetic acid moiety.	Proline	81-88	complement C2	Homo sapiens	188-191
8849687-1	1996	The antimicrobial and hemolytic activities of the 13-residue peptide indolicidin (ILPWKWPWWPWRR-NH2), present in bovine neutrophils, and its analogs have been determined with a view to gaining insight into the structural roles of tryptophan and proline.	Proline	245-252	cathelicidin-4	Bos taurus	69-80
8810341-7	1996	By examining the ability of different SH3 domains to interact with deletion variants of Sam 68 and WASP, we demonstrated that the Itk-SH3 domain and the SH3 domains of Src family kinases bind to overlapping but distinct sets of proline-rich regions in Sam 68 and WASP.	Proline	228-235	KH domain containing, RNA binding, signal transduction associated 1	Mus musculus	88-94
8810341-7	1996	By examining the ability of different SH3 domains to interact with deletion variants of Sam 68 and WASP, we demonstrated that the Itk-SH3 domain and the SH3 domains of Src family kinases bind to overlapping but distinct sets of proline-rich regions in Sam 68 and WASP.	Proline	228-235	Wiskott-Aldrich syndrome	Mus musculus	99-103
8810341-7	1996	By examining the ability of different SH3 domains to interact with deletion variants of Sam 68 and WASP, we demonstrated that the Itk-SH3 domain and the SH3 domains of Src family kinases bind to overlapping but distinct sets of proline-rich regions in Sam 68 and WASP.	Proline	228-235	IL2 inducible T cell kinase	Mus musculus	130-133
8810341-7	1996	By examining the ability of different SH3 domains to interact with deletion variants of Sam 68 and WASP, we demonstrated that the Itk-SH3 domain and the SH3 domains of Src family kinases bind to overlapping but distinct sets of proline-rich regions in Sam 68 and WASP.	Proline	228-235	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	168-171
8810341-7	1996	By examining the ability of different SH3 domains to interact with deletion variants of Sam 68 and WASP, we demonstrated that the Itk-SH3 domain and the SH3 domains of Src family kinases bind to overlapping but distinct sets of proline-rich regions in Sam 68 and WASP.	Proline	228-235	KH domain containing, RNA binding, signal transduction associated 1	Mus musculus	252-258
8810341-7	1996	By examining the ability of different SH3 domains to interact with deletion variants of Sam 68 and WASP, we demonstrated that the Itk-SH3 domain and the SH3 domains of Src family kinases bind to overlapping but distinct sets of proline-rich regions in Sam 68 and WASP.	Proline	228-235	Wiskott-Aldrich syndrome	Mus musculus	263-267
8917094-5	1996	In the transcriptional regulatory region, however, three domains, a glycine stretch, a proline stretch and one alternative splice site which are present in the mammalian WT1, are not conserved in amphibians.	Proline	87-94	WT1 transcription factor	Homo sapiens	170-173
8912808-5	1996	At relatively low concentrations (30 pmol/1 to 30 nmol/l), PGE2 stimulated an increase in the incorporation of [3H]proline into collagenase digestible protein (CDP) (P &lt; 0.01, n = 5) whereas at high levels (300 nmol/l to 3 micromol/l) of the eicosanoid, incorporation diminished precipitously.	Proline	115-122	cut like homeobox 1	Homo sapiens	160-163
8912808-6	1996	Human IGF-1 mimicked the effects of low PGE2 concentrations by stimulating in a dose-dependent (ANOVA, F= 31.65, P &lt; 0.001, n = 3) and saturable fashion the incorporation of [3H]proline into CDP although the magnitude of the response induced by IGF-1 was far greater (3.5-fold).	Proline	181-188	insulin like growth factor 1	Homo sapiens	6-11
8912808-8	1996	Furthermore, the PGE2-induced increase in [3H]proline incorporation into CDP was inhibited (63%, P &lt; 0.001, n = 7) by the addition to the culture medium of an anti-IGF-1 antibody.	Proline	46-53	cut like homeobox 1	Homo sapiens	73-76
8912808-8	1996	Furthermore, the PGE2-induced increase in [3H]proline incorporation into CDP was inhibited (63%, P &lt; 0.001, n = 7) by the addition to the culture medium of an anti-IGF-1 antibody.	Proline	46-53	insulin like growth factor 1	Homo sapiens	167-172
8816448-1	1996	Expression of the SPRR2A gene, a member of the small proline-rich family of cornified cell envelope precursor proteins, is strictly linked to keratinocyte terminal differentiation both in vivo and in vitro.	Proline	53-60	small proline rich protein 2A	Homo sapiens	18-24
8910008-5	1996	Amino acid analysis of the glycopolypeptides showed a close similarity to the expected ratio of serine:threonine:proline for MUC2 and did not vary between control and colitis groups.	Proline	113-120	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	125-129
8794290-1	1996	The proline-rich tandem repeat domain of human mucin MUC1 forms an extended structure containing large repeating loops that are crested by a turn.	Proline	4-11	LOC100508689	Homo sapiens	47-52
8794290-1	1996	The proline-rich tandem repeat domain of human mucin MUC1 forms an extended structure containing large repeating loops that are crested by a turn.	Proline	4-11	mucin 1, cell surface associated	Homo sapiens	53-57
8794306-4	1996	A proline-rich repeat sequence [(Pxx)4] in Nef occurring between amino acid residues 69 to 78 is highly conserved and bears strong resemblance to a defined consensus sequence identified as an SH3 binding domain present in several proteins which can interact with the SH3 domain of various signalling and cytoskeletal proteins.	Proline	2-9	S100 calcium binding protein B	Homo sapiens	43-46
8794306-5	1996	Binding and coprecipitation assays with short synthetic peptides corresponding to the proline-rich repeat sequence [(Pxx)4] of Nef and the SH2, SH3, or SH2 and SH3 domains of Lck revealed that the interaction between these two proteins is at least in part mediated by the proline repeat sequence of Nef and the SH3 domain of Lck.	Proline	272-279	S100 calcium binding protein B	Homo sapiens	127-130
8794306-5	1996	Binding and coprecipitation assays with short synthetic peptides corresponding to the proline-rich repeat sequence [(Pxx)4] of Nef and the SH2, SH3, or SH2 and SH3 domains of Lck revealed that the interaction between these two proteins is at least in part mediated by the proline repeat sequence of Nef and the SH3 domain of Lck.	Proline	272-279	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	175-178
8794306-6	1996	In addition to direct binding to full-length Nef, MAPK was also shown to bind the same proline repeat motif.	Proline	87-94	S100 calcium binding protein B	Homo sapiens	45-48
8906616-2	1996	The CR16 open reading frame encodes a 45 kDa protein containing 32% proline.	Proline	68-75	WAS/WASL interacting protein family, member 3	Rattus norvegicus	4-8
8816480-6	1996	The MAP kinase phosphorylation sites are clustered within a region encompassing three proline-rich SH3-binding sites in the C-terminal domain of hSos1.	Proline	86-93	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	145-150
8856051-6	1996	Partial N-terminal sequence analysis further shows that it is proline rich and shares more than 60% identity in a 28-amino-acid overlap with the mature form of bactenecin 7, an antimicrobial peptide from bovine neutrophils which belongs to the cathelicidin family of mammalian peptide antibiotics.	Proline	62-69	cathelicidin-3	Bos taurus	160-172
8855243-0	1996	Rapid refolding of a proline-rich all-beta-sheet fibronectin type III module.	Proline	21-28	fibronectin 1	Homo sapiens	49-60
8798556-7	1996	N-terminally truncated (delta1-82) MxB protein lacking both the nuclear localization signal and a proline-rich domain had almost completely lost its GTPase activity.	Proline	98-105	MX dynamin like GTPase 2	Homo sapiens	35-38
8862424-8	1996	We observe that, in addition to the membrane targeting signal and the conserved arg-arg residues within the core region, mutations in the proline-rich domain of Nef also affect its ability to associate with the serine kinase activity.	Proline	138-145	S100 calcium binding protein B	Homo sapiens	161-164
8862424-11	1996	In contrast, the proline-rich region of Nef is found to be involved in mediating efficient proviral DNA synthesis and the enhanced virion-infectivity function, but is not necessary for CD4 down-modulation by Nef.	Proline	17-24	S100 calcium binding protein B	Homo sapiens	40-43
8862424-13	1996	These findings define three functional domains of Nef that are required for its interaction with the serine kinase activity and suggest that the cellular interaction events via the myristoylation and arg-arg regions of Nef lie upstream of the interaction event via the proline-rich domain.	Proline	269-276	S100 calcium binding protein B	Homo sapiens	50-53
8862424-13	1996	These findings define three functional domains of Nef that are required for its interaction with the serine kinase activity and suggest that the cellular interaction events via the myristoylation and arg-arg regions of Nef lie upstream of the interaction event via the proline-rich domain.	Proline	269-276	S100 calcium binding protein B	Homo sapiens	219-222
8997162-7	1996	The exposure to high glucose and the treatment with Ang II or TGF-beta significantly increased collagen synthesis, measured by [3H]proline incorporation.	Proline	131-138	angiotensinogen	Rattus norvegicus	52-58
8997162-7	1996	The exposure to high glucose and the treatment with Ang II or TGF-beta significantly increased collagen synthesis, measured by [3H]proline incorporation.	Proline	131-138	transforming growth factor, beta 1	Rattus norvegicus	62-70
8997162-8	1996	The Ang II -or TGF-beta-induced increase of [3H]proline incorporation did not show changes under high glucose culture condition, compared to normal glucose concentration(Ang II, 27880 +/- 3560 cpm vs 26978 +/- 2284, TGF-beta, 26559 +/- 3700 vs 25800 +/- 1660, p &gt; 0.05).	Proline	48-55	angiotensinogen	Rattus norvegicus	4-10
8997162-8	1996	The Ang II -or TGF-beta-induced increase of [3H]proline incorporation did not show changes under high glucose culture condition, compared to normal glucose concentration(Ang II, 27880 +/- 3560 cpm vs 26978 +/- 2284, TGF-beta, 26559 +/- 3700 vs 25800 +/- 1660, p &gt; 0.05).	Proline	48-55	transforming growth factor, beta 1	Rattus norvegicus	15-23
8836115-3	1996	The bacterial protein ActA binds VASP via a proline-rich motif that is very similar to a sequence in the proline-rich region of the focal-adhesion protein vinculin.	Proline	105-112	vasodilator stimulated phosphoprotein	Homo sapiens	33-37
8836115-3	1996	The bacterial protein ActA binds VASP via a proline-rich motif that is very similar to a sequence in the proline-rich region of the focal-adhesion protein vinculin.	Proline	105-112	vinculin	Homo sapiens	155-163
8836115-4	1996	We have examined the ability of VASP, synthesized using an in vitro transcription/translation system, to bind to a series of vinculin peptides expressed as glutathione S-transferase fusion proteins, and have shown that it binds specifically to the proline-rich region in vinculin.	Proline	248-255	vasodilator stimulated phosphoprotein	Homo sapiens	32-36
8836115-5	1996	Using immobilized peptides corresponding to the two proline-rich motifs within this domain, the VASP-binding site was localized to proline-rich motif-l (residues 839-850).	Proline	52-59	vasodilator stimulated phosphoprotein	Homo sapiens	96-100
8836115-5	1996	Using immobilized peptides corresponding to the two proline-rich motifs within this domain, the VASP-binding site was localized to proline-rich motif-l (residues 839-850).	Proline	131-138	vasodilator stimulated phosphoprotein	Homo sapiens	96-100
8836115-0	1996	The focal-adhesion vasodilator-stimulated phosphoprotein (VASP) binds to the proline-rich domain in vinculin.	Proline	77-84	vasodilator stimulated phosphoprotein	Homo sapiens	19-56
8836115-0	1996	The focal-adhesion vasodilator-stimulated phosphoprotein (VASP) binds to the proline-rich domain in vinculin.	Proline	77-84	vasodilator stimulated phosphoprotein	Homo sapiens	58-62
8836115-0	1996	The focal-adhesion vasodilator-stimulated phosphoprotein (VASP) binds to the proline-rich domain in vinculin.	Proline	77-84	vinculin	Homo sapiens	100-108
8836115-3	1996	The bacterial protein ActA binds VASP via a proline-rich motif that is very similar to a sequence in the proline-rich region of the focal-adhesion protein vinculin.	Proline	44-51	vasodilator stimulated phosphoprotein	Homo sapiens	33-37
8892092-5	1996	Self-peptide mixtures eluted from the mouse H-2Kk class I allele revealed a dominant primary sequence motif, with a carboxyl-terminal residue that appeared to be invariantly valine and a secondary or auxiliary anchor residue at position 2 that could be either glutamate or proline.	Proline	273-280	histocompatibility 2, K1, K region	Mus musculus	44-49
8836115-3	1996	The bacterial protein ActA binds VASP via a proline-rich motif that is very similar to a sequence in the proline-rich region of the focal-adhesion protein vinculin.	Proline	44-51	vinculin	Homo sapiens	155-163
8784202-4	1996	A 1000-fold difference in Kon values was observed between the fastest (P2 proline) and the slowest (P2 threonine) inhibitors of thrombin.	Proline	74-81	coagulation factor II, thrombin	Homo sapiens	128-136
8703027-5	1996	The binding is specific to this domain among several SH3 domains including the C-terminal one of p47(phox) and the two of p67(phox) and requires the Pro156-containing proline-rich sequence but not other putative SH3 domain-binding sites of p22(phox).	Proline	167-174	pleckstrin	Homo sapiens	97-100
8703027-5	1996	The binding is specific to this domain among several SH3 domains including the C-terminal one of p47(phox) and the two of p67(phox) and requires the Pro156-containing proline-rich sequence but not other putative SH3 domain-binding sites of p22(phox).	Proline	167-174	pleckstrin	Homo sapiens	101-105
8703027-5	1996	The binding is specific to this domain among several SH3 domains including the C-terminal one of p47(phox) and the two of p67(phox) and requires the Pro156-containing proline-rich sequence but not other putative SH3 domain-binding sites of p22(phox).	Proline	167-174	CD33 molecule	Homo sapiens	122-125
8703027-5	1996	The binding is specific to this domain among several SH3 domains including the C-terminal one of p47(phox) and the two of p67(phox) and requires the Pro156-containing proline-rich sequence but not other putative SH3 domain-binding sites of p22(phox).	Proline	167-174	pleckstrin	Homo sapiens	126-130
8784202-6	1996	The nature of the P2 residue also affected whether the interaction of the serpin with the protease resulted in inhibition of the protease or cleavage of the serpin; a P2 proline residue increased the rate of cleavage of alpha 1-antichymotrypsin by trypsin.	Proline	170-177	serpin family A member 3	Homo sapiens	220-244
8703027-5	1996	The binding is specific to this domain among several SH3 domains including the C-terminal one of p47(phox) and the two of p67(phox) and requires the Pro156-containing proline-rich sequence but not other putative SH3 domain-binding sites of p22(phox).	Proline	167-174	calcineurin like EF-hand protein 1	Homo sapiens	240-243
8703027-5	1996	The binding is specific to this domain among several SH3 domains including the C-terminal one of p47(phox) and the two of p67(phox) and requires the Pro156-containing proline-rich sequence but not other putative SH3 domain-binding sites of p22(phox).	Proline	167-174	pleckstrin	Homo sapiens	126-130
8781442-3	1996	This sequence encodes one of two Src homology 3 domains and a part of proline-rich domain in p67-phox and lack of these domains seem to have influenced stability of this protein.	Proline	70-77	CD33 molecule	Homo sapiens	93-96
8703027-8	1996	These findings provide direct evidence that the interaction between the N-terminal SH3 domain of p47(phox) and the proline-rich region of p22(phox) is essential for activation of the NADPH oxidase.	Proline	115-122	pleckstrin	Homo sapiens	97-106
8703027-8	1996	These findings provide direct evidence that the interaction between the N-terminal SH3 domain of p47(phox) and the proline-rich region of p22(phox) is essential for activation of the NADPH oxidase.	Proline	115-122	calcineurin like EF-hand protein 1	Homo sapiens	138-141
8703027-8	1996	These findings provide direct evidence that the interaction between the N-terminal SH3 domain of p47(phox) and the proline-rich region of p22(phox) is essential for activation of the NADPH oxidase.	Proline	115-122	pleckstrin	Homo sapiens	101-105
8843777-0	1996	Effect of luminal epidermal growth factor on enterocyte glucose and proline transport.	Proline	68-75	pro-epidermal growth factor	Oryctolagus cuniculus	18-41
8843777-4	1996	Luminal EGF significantly (P &lt; 0.0001) increased the maximal rate of transport (Vmax) for glucose and proline uptake in BBMV.	Proline	105-112	pro-epidermal growth factor	Oryctolagus cuniculus	8-11
8790146-0	1996	Hb Utrecht [alpha 2 129(H12)Leu-->Pro], a new unstable alpha 2-chain variant associated with a mild alpha-thalassaemic phenotype.	Proline	34-37	glycoprotein hormone subunit alpha 2	Homo sapiens	12-19
8790146-0	1996	Hb Utrecht [alpha 2 129(H12)Leu-->Pro], a new unstable alpha 2-chain variant associated with a mild alpha-thalassaemic phenotype.	Proline	34-37	glycoprotein hormone subunit alpha 2	Homo sapiens	55-62
8707297-2	1996	Cloning and sequencing of the breakpoint revealed that the deletion starts in intron 10 of the PAX6 gene and removes the C-terminal part of the proline-serine-threonine rich domain, leaving both DNA-binding domains intact.	Proline	144-151	paired box 6	Homo sapiens	95-99
8805372-7	1996	In vitro, the mNUMB PTB domain binds phosphotyrosine-containing proteins, and SH3 domains of SRC-family tyrosine kinases bind to mNUMB presumably through interactions with proline-rich regions in the carboxyl terminus.	Proline	172-179	NUMB endocytic adaptor protein	Mus musculus	14-19
8805372-7	1996	In vitro, the mNUMB PTB domain binds phosphotyrosine-containing proteins, and SH3 domains of SRC-family tyrosine kinases bind to mNUMB presumably through interactions with proline-rich regions in the carboxyl terminus.	Proline	172-179	NUMB endocytic adaptor protein	Mus musculus	129-134
8872474-4	1996	The translocation is predicted to result in the fusion of the N-terminal region of the PRCC protein, which includes a proline-rich domain, to the entire TFE3 protein.	Proline	118-125	proline rich mitotic checkpoint control factor	Homo sapiens	87-91
8872474-4	1996	The translocation is predicted to result in the fusion of the N-terminal region of the PRCC protein, which includes a proline-rich domain, to the entire TFE3 protein.	Proline	118-125	transcription factor binding to IGHM enhancer 3	Homo sapiens	153-157
9183643-1	1996	CD26 is a 110 kDa T cell activation antigen and has been shown to have DPPIV enzyme activity which cleaves amino-terminal dipeptides with either L-proline or L-alanine at the penultimate position.	Proline	145-154	dipeptidyl peptidase 4	Homo sapiens	0-4
11725115-7	1996	The substitution of Leu residues 188 and 190 with Pro at the regulatory domain of TH reduces enzymatic TH activity without affecting tetramer formation.	Proline	50-53	tyrosine hydroxylase	Homo sapiens	82-84
8921216-2	1996	METHOD: We prepared antibodies raised against proline coupled to bovine serum albumin (BSA) with glutaraldehyde.	Proline	46-53	albumin	Rattus norvegicus	72-85
11725115-7	1996	The substitution of Leu residues 188 and 190 with Pro at the regulatory domain of TH reduces enzymatic TH activity without affecting tetramer formation.	Proline	50-53	tyrosine hydroxylase	Homo sapiens	103-105
8703082-3	1996	Alanine, glycine, and proline repeats were present in the mammalian Brain-1 gene, whereas most of these repeats were absent in the nonmammalian homologue.	Proline	22-29	POU class 3 homeobox 3	Homo sapiens	68-75
8906538-2	1996	At least two early events are necessary for full activation of cPLA2: (1) increased concentration of cytosolic free Ca2+ promoting association of cPLA2 with its membrane phospholipid substrate and (2) phosphorylation by stimulated proline-directed kinases converting cPLA2 into an enzyme of enhanced catalytic efficiency.	Proline	231-238	phospholipase A2 group IVA	Homo sapiens	63-68
8897075-7	1996	Among these are a conserved 18-amino acid motif, which is known to mediate binding to MTs and a part of the MT-binding domain known as the proline-rich region, which is thought to be the regulatory domain of MAP4.	Proline	139-146	microtubule associated protein 4	Gallus gallus	208-212
8703082-4	1996	The mammalian Brain-2 gene had alanine, glycine, proline, and glutamine repeats, which were missing in the nonmammalian homologue.	Proline	49-56	POU class 3 homeobox 2	Homo sapiens	14-21
8703082-5	1996	The mammalian Scip gene had alanine, glycine, proline, and histidine repeats, but the nonmammalian homologue completely lacked these repeats.	Proline	46-53	POU class 3 homeobox 1	Homo sapiens	14-18
8702879-4	1996	To identify the kinase involved, three proline-directed protein kinases expressed highly in the brain, i.e. mitogen-activated protein (MAP) kinase, Cdk5-p23, and glycogen synthase kinase 3beta, were tested for the in vitro phosphorylation of synapsin I.	Proline	39-46	cyclin dependent kinase 5	Homo sapiens	148-152
8877818-2	1996	The amplification was achieved using two primers which correspond to TRH progenitor sequence (Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg).	Proline	114-117	thyrotropin-releasing hormone L homeolog	Xenopus laevis	69-72
8890040-2	1996	The majority (8/12) of anti-gp46/175-Pro-199-positive sera reacted also to gp46/190-Pro-199 or to gp46/ 190-Ser-199, demonstrating their neutralizing properties.	Proline	37-40	serpin family H member 1	Homo sapiens	28-32
8890040-2	1996	The majority (8/12) of anti-gp46/175-Pro-199-positive sera reacted also to gp46/190-Pro-199 or to gp46/ 190-Ser-199, demonstrating their neutralizing properties.	Proline	37-40	serpin family H member 1	Homo sapiens	75-79
8890040-2	1996	The majority (8/12) of anti-gp46/175-Pro-199-positive sera reacted also to gp46/190-Pro-199 or to gp46/ 190-Ser-199, demonstrating their neutralizing properties.	Proline	37-40	serpin family H member 1	Homo sapiens	75-79
8890040-2	1996	The majority (8/12) of anti-gp46/175-Pro-199-positive sera reacted also to gp46/190-Pro-199 or to gp46/ 190-Ser-199, demonstrating their neutralizing properties.	Proline	84-87	serpin family H member 1	Homo sapiens	28-32
8890040-2	1996	The majority (8/12) of anti-gp46/175-Pro-199-positive sera reacted also to gp46/190-Pro-199 or to gp46/ 190-Ser-199, demonstrating their neutralizing properties.	Proline	84-87	serpin family H member 1	Homo sapiens	75-79
8890040-2	1996	The majority (8/12) of anti-gp46/175-Pro-199-positive sera reacted also to gp46/190-Pro-199 or to gp46/ 190-Ser-199, demonstrating their neutralizing properties.	Proline	84-87	serpin family H member 1	Homo sapiens	75-79
8702917-1	1996	The Src homology 2 (SH2) domain of the mammalian adaptor protein Crk-II contains a proline-rich insert, predicted to lie within an extended DE loop, which is dispensable for phosphopeptide binding.	Proline	83-90	CRK proto-oncogene, adaptor protein	Homo sapiens	65-71
8702917-3	1996	Furthermore, this proline-rich insert was found to modify the efficiency with which Crk-II was phosphorylated by the p140(c-abl) tyrosine kinase.	Proline	18-25	CRK proto-oncogene, adaptor protein	Homo sapiens	84-90
8702917-3	1996	Furthermore, this proline-rich insert was found to modify the efficiency with which Crk-II was phosphorylated by the p140(c-abl) tyrosine kinase.	Proline	18-25	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	122-127
8890040-5	1996	The mean specific activity of IgG to gp46/175-Pro-199 showed a trend to be higher in cervicovaginal secretions (218 +/- 109) than in sera (14 +/- 4).	Proline	46-49	serpin family H member 1	Homo sapiens	37-41
8890040-8	1996	In conclusion, IgG to gp46/175-Pro-199 in cervicovaginal secretions, when present, appear to be produced primarily locally because of local HTLV-I excretion.	Proline	31-34	serpin family H member 1	Homo sapiens	22-26
8709224-7	1996	Deletion mutation analysis of EBNA2 shows that the proline-rich aminoterminal end and a domain within the divergent region of EBNA2 mediate EBNA2-hSNF5/Ini1 interaction.	Proline	51-58	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	146-151
8709224-7	1996	Deletion mutation analysis of EBNA2 shows that the proline-rich aminoterminal end and a domain within the divergent region of EBNA2 mediate EBNA2-hSNF5/Ini1 interaction.	Proline	51-58	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	152-156
8756676-11	1996	Within the minimal active fragment of Ku86 necessary for subunit interaction (aa 449 to 732) and DNA binding (aa 334 to 732), a proline-rich region is the only defined motif.	Proline	128-135	X-ray repair cross complementing 5	Homo sapiens	38-42
8702917-6	1996	NMR spectroscopic analysis showed that binding of the Tyr-221 phosphopeptide to the Crk SH2 domain induced a chemical shift change in Val-71, located in the proline-rich insert, indicative of a change in the structure of the proline-rich loop in response of Crk SH2-pTyr-221 interaction.	Proline	157-164	CRK proto-oncogene, adaptor protein	Homo sapiens	84-87
8702917-6	1996	NMR spectroscopic analysis showed that binding of the Tyr-221 phosphopeptide to the Crk SH2 domain induced a chemical shift change in Val-71, located in the proline-rich insert, indicative of a change in the structure of the proline-rich loop in response of Crk SH2-pTyr-221 interaction.	Proline	157-164	CRK proto-oncogene, adaptor protein	Homo sapiens	258-261
8702917-6	1996	NMR spectroscopic analysis showed that binding of the Tyr-221 phosphopeptide to the Crk SH2 domain induced a chemical shift change in Val-71, located in the proline-rich insert, indicative of a change in the structure of the proline-rich loop in response of Crk SH2-pTyr-221 interaction.	Proline	225-232	CRK proto-oncogene, adaptor protein	Homo sapiens	84-87
8702879-4	1996	To identify the kinase involved, three proline-directed protein kinases expressed highly in the brain, i.e. mitogen-activated protein (MAP) kinase, Cdk5-p23, and glycogen synthase kinase 3beta, were tested for the in vitro phosphorylation of synapsin I.	Proline	39-46	synapsin I	Homo sapiens	242-252
8702840-6	1996	Here we further report that NF-H is extensively modified by O-GlcNAc at Thr53, Ser54, and Ser56 in the head domain and, somewhat surprisingly, at multiple sites within the Lys-Ser-Pro repeat motif in the tail domain, a region in assembled neurofilaments known to be nearly stoichiometrically phosphorylated on each of the approximately 50 KSP repeats.	Proline	180-183	neurofilament heavy chain	Homo sapiens	28-32
8702917-6	1996	NMR spectroscopic analysis showed that binding of the Tyr-221 phosphopeptide to the Crk SH2 domain induced a chemical shift change in Val-71, located in the proline-rich insert, indicative of a change in the structure of the proline-rich loop in response of Crk SH2-pTyr-221 interaction.	Proline	225-232	CRK proto-oncogene, adaptor protein	Homo sapiens	258-261
8702917-7	1996	These results suggest that the proline-rich insert in the Crk SH2 domain constitutes an SH3 domain-binding site that can be regulated by binding of a phosphopeptide ligand to the Crk SH2 domain.	Proline	31-38	CRK proto-oncogene, adaptor protein	Homo sapiens	58-61
8702917-7	1996	These results suggest that the proline-rich insert in the Crk SH2 domain constitutes an SH3 domain-binding site that can be regulated by binding of a phosphopeptide ligand to the Crk SH2 domain.	Proline	31-38	CRK proto-oncogene, adaptor protein	Homo sapiens	179-182
8798379-4	1996	The association between Nck and Pak1 is mediated by the second SH3 domain of Nck and a proline-rich sequence in the amino terminus of Pak1.	Proline	87-94	NCK adaptor protein 1	Homo sapiens	24-27
8798379-4	1996	The association between Nck and Pak1 is mediated by the second SH3 domain of Nck and a proline-rich sequence in the amino terminus of Pak1.	Proline	87-94	p21 (RAC1) activated kinase 1	Homo sapiens	32-36
8798379-4	1996	The association between Nck and Pak1 is mediated by the second SH3 domain of Nck and a proline-rich sequence in the amino terminus of Pak1.	Proline	87-94	p21 (RAC1) activated kinase 1	Homo sapiens	134-138
8702834-10	1996	Amino acid mutations in the acceptor regions demonstrated the importance of proline as a necessary feature for O-linked recognition in the CGbeta sequence.	Proline	76-83	chorionic gonadotropin subunit beta 3	Homo sapiens	139-145
8702841-2	1996	Here we show that within the neuronally expressed Oct-2.5 form, the inhibitory domain can strongly inhibit activation by transcription factor activation domains which are either composed predominantly of acidic residues or contain the HOB motif, whereas it has a weaker effect or no effect on proline-rich activation domains and on a glutamine-rich domain.	Proline	293-300	POU class 2 homeobox 2	Homo sapiens	50-55
8897476-5	1996	These approaches reveal that NPY is processed at its N-terminus by two proline-preferring aminopeptidases: aminopeptidase P and dipeptidyl peptidase IV.	Proline	71-78	neuropeptide Y	Homo sapiens	29-32
8897476-5	1996	These approaches reveal that NPY is processed at its N-terminus by two proline-preferring aminopeptidases: aminopeptidase P and dipeptidyl peptidase IV.	Proline	71-78	dipeptidyl peptidase 4	Homo sapiens	128-151
8799157-4	1996	Affected members of two seemingly unrelated families with EBS-MP had a C to T point mutation in the second base position of codon 24 of one of two K5 alleles, leading to a Pro: Leu mutation.	Proline	172-175	keratin 5	Homo sapiens	147-149
8757285-3	1996	Two components of the NADPH oxidase, p67phox and p47phox, each contain two SH3 domains and we have previously shown that the SH3 domain near the carboxyl terminus of p67phox interacts with a proline-rich region of p47phox.	Proline	191-198	neutrophil cytosolic factor 2	Homo sapiens	37-44
8757285-3	1996	Two components of the NADPH oxidase, p67phox and p47phox, each contain two SH3 domains and we have previously shown that the SH3 domain near the carboxyl terminus of p67phox interacts with a proline-rich region of p47phox.	Proline	191-198	neutrophil cytosolic factor 1	Homo sapiens	49-56
8757285-3	1996	Two components of the NADPH oxidase, p67phox and p47phox, each contain two SH3 domains and we have previously shown that the SH3 domain near the carboxyl terminus of p67phox interacts with a proline-rich region of p47phox.	Proline	191-198	neutrophil cytosolic factor 2	Homo sapiens	166-173
8757285-3	1996	Two components of the NADPH oxidase, p67phox and p47phox, each contain two SH3 domains and we have previously shown that the SH3 domain near the carboxyl terminus of p67phox interacts with a proline-rich region of p47phox.	Proline	191-198	neutrophil cytosolic factor 1	Homo sapiens	214-221
8757285-5	1996	The model suggests that the proline-rich ligand of p47phox can bind to the SH3 domain in either of two orientations.	Proline	28-35	neutrophil cytosolic factor 1	Homo sapiens	51-58
8702571-1	1996	SPRK (also called PTK-1 and MLK-3), a member of the mixed lineage kinase subfamily of (Ser/Thr) protein kinases, encodes an amino-terminal SH3 domain followed by a kinase catalytic domain, two leucine zippers interrupted by a short spacer, a Rac/Cdc42 binding domain, and a long carboxyl-terminal proline-rich region.	Proline	297-304	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	0-4
8806728-5	1996	Increased proliferation rates in BaP cells correlated with increased synthesis and secretion of proline-containing proteins.	Proline	96-103	prohibitin 2	Rattus norvegicus	33-36
8757138-3	1996	Here we investigate the solution structure of the WW domain of human YAP65 (for Yes kinase-associated protein) in complex with proline-rich peptides containing the core motif PPxY.	Proline	127-134	Yes1 associated transcriptional regulator	Homo sapiens	69-74
8700229-4	1996	The CES-2 protein is most similar to members of the PAR (proline- and acid-rich) subfamily of bZIP proteins and has DNA-binding specificity like that of PAR-family proteins.	Proline	57-64	Cell death specification protein 2	Caenorhabditis elegans	4-9
8702571-1	1996	SPRK (also called PTK-1 and MLK-3), a member of the mixed lineage kinase subfamily of (Ser/Thr) protein kinases, encodes an amino-terminal SH3 domain followed by a kinase catalytic domain, two leucine zippers interrupted by a short spacer, a Rac/Cdc42 binding domain, and a long carboxyl-terminal proline-rich region.	Proline	297-304	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	18-23
8702571-1	1996	SPRK (also called PTK-1 and MLK-3), a member of the mixed lineage kinase subfamily of (Ser/Thr) protein kinases, encodes an amino-terminal SH3 domain followed by a kinase catalytic domain, two leucine zippers interrupted by a short spacer, a Rac/Cdc42 binding domain, and a long carboxyl-terminal proline-rich region.	Proline	297-304	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	28-33
8710950-5	1996	During recovery from osmotic stress, accumulated proline is rapidly oxidized to glutamate and the first step of this process is catalyzed by proline oxidase.	Proline	49-56	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	141-156
8710855-3	1996	Both Hoxa-3 and Hoxa-3 proteins have a proline-rich region that contains consensus amino acid sequences for binding to Src homology 3 domains of some signal transduction proteins.	Proline	39-46	homeobox A3	Mus musculus	5-11
8769125-7	1996	The presence of an SH2 domain and proline-rich sequence motifs within hp51CN suggests that this 5-phosphatase interacts with various proteins in signal transduction.	Proline	34-41	inositol polyphosphate-5-phosphatase D	Homo sapiens	70-76
8710855-3	1996	Both Hoxa-3 and Hoxa-3 proteins have a proline-rich region that contains consensus amino acid sequences for binding to Src homology 3 domains of some signal transduction proteins.	Proline	39-46	homeobox A3	Mus musculus	16-22
8760502-2	1996	The elastic portion of titin comprises two distinct structural motifs, immunoglobulin (Ig) domains and the PEVK titin, which is a novel motif family rich in proline, glutamate, valine and lysine residues.	Proline	157-164	titin	Homo sapiens	23-28
8760502-2	1996	The elastic portion of titin comprises two distinct structural motifs, immunoglobulin (Ig) domains and the PEVK titin, which is a novel motif family rich in proline, glutamate, valine and lysine residues.	Proline	157-164	titin	Homo sapiens	112-117
8761480-11	1996	This interaction seems to be governed by alternative splicing of the PDE4A gene, because RPDE-39, a splice variant that lacks the proline-rich N-terminal splice region of RPDE-6, does not interact with these SH3 domains.	Proline	130-137	phosphodiesterase 4A	Rattus norvegicus	69-74
8899662-6	1996	The selective increase in activity of proline endopeptidase and pyroglutamyl aminopeptidase in ALS may represent an adaptation to maintain excitatory drive to surviving motor neurons by increased processing of TRH to its active metabolite.	Proline	38-45	thyrotropin releasing hormone	Homo sapiens	210-213
8760383-8	1996	We observed the strongest attachment between p40phox and p67phox where the binding was between the N-terminal half of p67phox and the C-terminal half of p40phox, and did not appear to involve SH3 domains and proline-rich sequences.	Proline	208-215	neutrophil cytosolic factor 4	Homo sapiens	45-52
8707840-5	1996	We found that p58 contains regions with FG (Phe, Gly) and PA (Pro, Ala) repeats at both its NH2 and COOH termini separated by a predicted alpha-helical coiled-coil region, while p54 has an NH2-terminal FG and PA repeat region and a COOH-terminal predicted coiled-coil region.	Proline	62-65	DNA primase subunit 2	Rattus norvegicus	14-17
8764091-7	1996	A proline-rich P(S/T)APP motif is found in many retroviral Gag polyproteins; the motif found in the p6 region of human immunodeficiency virus type 1 has been implicated in late functions of the virus.	Proline	2-9	Pr55(Gag)	Human immunodeficiency virus 1	59-62
8764025-1	1996	The cellular peptidyl-prolyl isomerase cyclophilin A is incorporated into human immunodeficiency virus type 1 virions via contacts with the proline-rich domain of the Gag polyprotein.	Proline	140-147	Pr55(Gag)	Human immunodeficiency virus 1	167-170
8752089-5	1996	All SF1 cDNAs identified encode proteins with a common N-terminal half that contains two structural motifs implicated in RNA binding (an hnRNP K homology [KH] domain and a zinc knuckle), but the proteins differ in the length of a proline-rich region and have distinct C-termini.	Proline	230-237	splicing factor 1	Homo sapiens	4-7
8764025-3	1996	Passage of human immunodeficiency virus type 1 in the presence of the drug selects one of two mutations, either of which alters the proline-rich domain of Gag and is sufficient to confer drug resistance on the cloned wild-type provirus.	Proline	132-139	Pr55(Gag)	Human immunodeficiency virus 1	155-158
8756326-2	1996	We show here, using proline scanning mutagenesis, that the native-like tertiary fold of the alpha-lactalbumin (alpha-LA) molten globule is formed by the non-cooperative assembly of its constituent helices.	Proline	20-27	lactalbumin alpha	Homo sapiens	92-109
8756326-2	1996	We show here, using proline scanning mutagenesis, that the native-like tertiary fold of the alpha-lactalbumin (alpha-LA) molten globule is formed by the non-cooperative assembly of its constituent helices.	Proline	20-27	lactalbumin alpha	Homo sapiens	111-119
8776899-0	1996	A nuclear gene encoding mitochondrial proline dehydrogenase, an enzyme involved in proline metabolism, is upregulated by proline but downregulated by dehydration in Arabidopsis.	Proline	83-90	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	38-59
8776899-4	1996	Sequence analysis of an Arabidopsis cDNA clone, ERD5 (for early responsive to dehydration stress), isolated from plants dehydrated for 1 hr, revealed that it encodes a protein with identity to products of the yeast PUT1 (for proline utilization) gene (23.6% over 364 amino acids) and the Drosophila sluggish-A gene (34.5% over 255 amino acids).	Proline	225-232	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	48-52
8776899-4	1996	Sequence analysis of an Arabidopsis cDNA clone, ERD5 (for early responsive to dehydration stress), isolated from plants dehydrated for 1 hr, revealed that it encodes a protein with identity to products of the yeast PUT1 (for proline utilization) gene (23.6% over 364 amino acids) and the Drosophila sluggish-A gene (34.5% over 255 amino acids).	Proline	225-232	proline dehydrogenase	Saccharomyces cerevisiae S288C	215-219
8776899-9	1996	Immunologically, we showed that the product of ERD5 is localized in the mitochondrial fraction and accumulates in response to proline in cultured cells.	Proline	126-133	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	47-51
8776899-10	1996	Fusion genes for ERD5 and PUT1 complemented a put1 mutant of yeast, allowing put1 to grow with proline as the source of nitrogen.	Proline	95-102	Methylenetetrahydrofolate reductase family protein	Arabidopsis thaliana	17-21
8776899-10	1996	Fusion genes for ERD5 and PUT1 complemented a put1 mutant of yeast, allowing put1 to grow with proline as the source of nitrogen.	Proline	95-102	proline dehydrogenase	Saccharomyces cerevisiae S288C	26-30
8776899-10	1996	Fusion genes for ERD5 and PUT1 complemented a put1 mutant of yeast, allowing put1 to grow with proline as the source of nitrogen.	Proline	95-102	proline dehydrogenase	Saccharomyces cerevisiae S288C	46-50
8755614-9	1996	The 115 region between Pro-247 and Pro-271 in KAT1 contains 14 additional amino acids when compared with Shaker [Aldrich, R. W. (1993) Nature (London) 362, 107-108].	Proline	23-26	histone acetyltransferase catalytic subunit HAT1	Saccharomyces cerevisiae S288C	46-50
8776899-10	1996	Fusion genes for ERD5 and PUT1 complemented a put1 mutant of yeast, allowing put1 to grow with proline as the source of nitrogen.	Proline	95-102	proline dehydrogenase	Saccharomyces cerevisiae S288C	77-81
8663276-8	1996	Mutation of the ICP10 proline-rich motifs at positions 396 and 149 reduced Grb2 binding 20- and 2-fold, respectively.	Proline	22-29	growth factor receptor bound protein 2	Homo sapiens	75-79
8755614-9	1996	The 115 region between Pro-247 and Pro-271 in KAT1 contains 14 additional amino acids when compared with Shaker [Aldrich, R. W. (1993) Nature (London) 362, 107-108].	Proline	35-38	histone acetyltransferase catalytic subunit HAT1	Saccharomyces cerevisiae S288C	46-50
8702432-0	1996	Substitution at codon 269 (glutamine --&gt; proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat.	Proline	44-51	leptin receptor	Rattus norvegicus	60-75
8698236-3	1996	The 7.0-kb mRNA arises from differential splicing-in of a 6.0 kb-exon giving rise to a proline-rich isoform that we termed skNAC.	Proline	87-94	nascent polypeptide-associated complex alpha polypeptide	Mus musculus	123-128
8702432-0	1996	Substitution at codon 269 (glutamine --&gt; proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat.	Proline	44-51	leptin receptor	Rattus norvegicus	77-81
8660897-3	1996	The GATA-6 and -4 proteins share high-level amino acid sequence identity over a proline-rich region at the amino terminus of the protein that is not conserved in other GATA family members.	Proline	80-87	GATA binding protein 6	Homo sapiens	4-17
8662505-4	1996	The proline residue Pro1 forms a salt bridge with a conserved, buried aspartate residue (Asp51), which suggests that the amino terminus of the protein rearranges upon proteolytic maturation.	Proline	4-11	lamin A/C	Homo sapiens	20-24
8706727-1	1996	The T-cell activation antigen CD26, is a type II membrane glycoprotein with intrinsic dipeptidyl-peptidase IV (DPP IV) activity, characterized by its capacity to cleave off N-terminal dipeptides containing proline as the penultimate residue.	Proline	206-213	dipeptidyl peptidase 4	Homo sapiens	30-34
8706727-1	1996	The T-cell activation antigen CD26, is a type II membrane glycoprotein with intrinsic dipeptidyl-peptidase IV (DPP IV) activity, characterized by its capacity to cleave off N-terminal dipeptides containing proline as the penultimate residue.	Proline	206-213	dipeptidyl peptidase 4	Homo sapiens	86-109
8706727-1	1996	The T-cell activation antigen CD26, is a type II membrane glycoprotein with intrinsic dipeptidyl-peptidase IV (DPP IV) activity, characterized by its capacity to cleave off N-terminal dipeptides containing proline as the penultimate residue.	Proline	206-213	dipeptidyl peptidase 4	Homo sapiens	111-117
8660897-3	1996	The GATA-6 and -4 proteins share high-level amino acid sequence identity over a proline-rich region at the amino terminus of the protein that is not conserved in other GATA family members.	Proline	80-87	GATA binding protein 4	Homo sapiens	4-8
8663151-5	1996	Abrogation of the TGF-beta-enhanced production of type I collagen in infected smooth muscle cells was confirmed by immunocytostaining and by [14C]proline incorporation in a quantitative manner.	Proline	146-153	transforming growth factor beta 1	Homo sapiens	18-26
11667409-6	1996	These NOE data are consistent with the structure expected for the more stable diastereomeric adsorbate formed between (S)-2 and the (S)-proline-derived CSP 1.	Proline	132-143	regulator of calcineurin 1	Homo sapiens	152-157
8809402-7	1996	The expressed protein contains multiple direct repeats of an 8-amino acid motif rich in proline, with significant homology to the cornifin, pig 20K, monkey MT5, and human small proline-rich genes spri and spril.	Proline	88-95	cornifin	Sus scrofa	130-138
8694762-2	1996	Cyclophilin is identical with peptidylprolyl cis-trans isomerase (PPI; EC 5.2.1.8), an enzyme which catalyses the isomerization between the two proline conformations in proteins, thereby acting as a catalyst in protein-folding events.	Proline	144-151	Peptidylprolyl isomerase	Caenorhabditis elegans	30-64
8694762-2	1996	Cyclophilin is identical with peptidylprolyl cis-trans isomerase (PPI; EC 5.2.1.8), an enzyme which catalyses the isomerization between the two proline conformations in proteins, thereby acting as a catalyst in protein-folding events.	Proline	144-151	Peptidylprolyl isomerase	Caenorhabditis elegans	66-69
8853442-10	1996	Two main functional regions have been defined in the cytoplasmic domain of the GH receptor by testing the activity of mutant forms of the receptor in several systems: Box 1, a proline-rich sequence in the membrane proximal part, is necessary for all GH effects and is probably the region of association with JAK2; the C-terminal region is required for the induction of specific genes.	Proline	176-183	growth hormone receptor	Homo sapiens	79-90
8853442-10	1996	Two main functional regions have been defined in the cytoplasmic domain of the GH receptor by testing the activity of mutant forms of the receptor in several systems: Box 1, a proline-rich sequence in the membrane proximal part, is necessary for all GH effects and is probably the region of association with JAK2; the C-terminal region is required for the induction of specific genes.	Proline	176-183	Janus kinase 2	Homo sapiens	308-312
8663233-7	1996	Peptide competition demonstrated that both Pro and Tyr residues were required for specific interaction of InsR with Enigma.	Proline	43-46	insulin receptor	Homo sapiens	106-110
8809402-8	1996	Esophagin constitutes the newest and largest member of this small proline-rich gene family and is associated with differentiation and the benign phenotype of the human esophageal epithelial cell.	Proline	66-73	small proline rich protein 3	Homo sapiens	0-9
8661114-6	1996	In contrast, the carboxy-terminal half of the mouse SIM protein consists of a proline-rich region with no sequence homology to the Drosophila SIM protein.	Proline	78-85	single-minded family bHLH transcription factor 2	Mus musculus	52-55
8840095-1	1996	The time-action profile of the insulin analogue insulin lispro ([Lys(B28), Pro(B29)] human insulin) with its rapid onset and short duration of action might be more suitable to limit hyperglycaemic excursions after a meal rich in rapidly absorbable carbohydrates in comparison to regular human insulin.	Proline	75-78	insulin	Homo sapiens	31-38
8840095-1	1996	The time-action profile of the insulin analogue insulin lispro ([Lys(B28), Pro(B29)] human insulin) with its rapid onset and short duration of action might be more suitable to limit hyperglycaemic excursions after a meal rich in rapidly absorbable carbohydrates in comparison to regular human insulin.	Proline	75-78	insulin	Homo sapiens	48-55
8840095-1	1996	The time-action profile of the insulin analogue insulin lispro ([Lys(B28), Pro(B29)] human insulin) with its rapid onset and short duration of action might be more suitable to limit hyperglycaemic excursions after a meal rich in rapidly absorbable carbohydrates in comparison to regular human insulin.	Proline	75-78	insulin	Homo sapiens	48-55
8840095-1	1996	The time-action profile of the insulin analogue insulin lispro ([Lys(B28), Pro(B29)] human insulin) with its rapid onset and short duration of action might be more suitable to limit hyperglycaemic excursions after a meal rich in rapidly absorbable carbohydrates in comparison to regular human insulin.	Proline	75-78	insulin	Homo sapiens	48-55
8832204-9	1996	Finally, dimerization is linked to the acquisition of LPH to its biological function, since only dimers of wild type pro-LPH or pro-LPH-ct are enzymatically active, while their monomeric counterparts as well as pro-LPH-mact are not.	Proline	117-120	lactase	Homo sapiens	54-57
8832204-9	1996	Finally, dimerization is linked to the acquisition of LPH to its biological function, since only dimers of wild type pro-LPH or pro-LPH-ct are enzymatically active, while their monomeric counterparts as well as pro-LPH-mact are not.	Proline	117-120	lactase	Homo sapiens	121-124
8832204-9	1996	Finally, dimerization is linked to the acquisition of LPH to its biological function, since only dimers of wild type pro-LPH or pro-LPH-ct are enzymatically active, while their monomeric counterparts as well as pro-LPH-mact are not.	Proline	117-120	lactase	Homo sapiens	121-124
8832204-9	1996	Finally, dimerization is linked to the acquisition of LPH to its biological function, since only dimers of wild type pro-LPH or pro-LPH-ct are enzymatically active, while their monomeric counterparts as well as pro-LPH-mact are not.	Proline	117-120	lactase	Homo sapiens	121-124
8690792-4	1996	Our results show that both Lyst and Lys- Lp(a)s and their derived apo(a)s, bound to PM-fibrinogen with similar affinities (Kds: 33-100 nM), whereas the B(max) values were threefold higher for apo(a)s. Both the lysine analog epsilon-aminocaproic acid and L-proline inhibited the binding of Lp(a) and apo(a) to PM fibrinogen.	Proline	254-263	lysosomal trafficking regulator	Homo sapiens	27-31
8766817-4	1996	The ability of proline-rich peptides homologous to the Sam68 primary sequence to inhibit the binding of Sam68 to SH3 domains was investigated.	Proline	15-22	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	104-109
8766817-6	1996	A peptide derived from residues 32-44 of Sam68 which fits the class II SH3 domain binding consensus sequence inhibited binding of Sam68 to both p85alpha SH3 domain and c-src SH3 domain, but with differential potency, suggesting a differential affinity of these SH3 domains for this proline-rich motif.	Proline	282-289	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	41-46
8766817-6	1996	A peptide derived from residues 32-44 of Sam68 which fits the class II SH3 domain binding consensus sequence inhibited binding of Sam68 to both p85alpha SH3 domain and c-src SH3 domain, but with differential potency, suggesting a differential affinity of these SH3 domains for this proline-rich motif.	Proline	282-289	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	130-135
8766817-6	1996	A peptide derived from residues 32-44 of Sam68 which fits the class II SH3 domain binding consensus sequence inhibited binding of Sam68 to both p85alpha SH3 domain and c-src SH3 domain, but with differential potency, suggesting a differential affinity of these SH3 domains for this proline-rich motif.	Proline	282-289	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	144-152
8766817-6	1996	A peptide derived from residues 32-44 of Sam68 which fits the class II SH3 domain binding consensus sequence inhibited binding of Sam68 to both p85alpha SH3 domain and c-src SH3 domain, but with differential potency, suggesting a differential affinity of these SH3 domains for this proline-rich motif.	Proline	282-289	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	168-173
8690792-5	1996	We conclude that the LBS of kringle IV-10 is not involved in this process and that apo(a) binds to PM-fibrinogen via a lysine-proline-sensitive domain located outside the LBS and largely masked by the interaction of apo(a) with apoB100.	Proline	126-133	aminopeptidase O (putative)	Homo sapiens	83-86
8781754-9	1996	LVH as well as hydroxyproline/proline ratio was diminished by ACE inhibitor treatment.	Proline	22-29	angiotensin I converting enzyme	Rattus norvegicus	62-65
8690792-4	1996	Our results show that both Lyst and Lys- Lp(a)s and their derived apo(a)s, bound to PM-fibrinogen with similar affinities (Kds: 33-100 nM), whereas the B(max) values were threefold higher for apo(a)s. Both the lysine analog epsilon-aminocaproic acid and L-proline inhibited the binding of Lp(a) and apo(a) to PM fibrinogen.	Proline	254-263	lipoprotein(a)	Homo sapiens	41-46
8691150-9	1996	The PEST (proline-, glutamic acid-, serine-, and threonine-rich region) sequence of the PU.1 protein, which is an important domain for protein-protein interactions in B cells, was found to have no influence on PU.1-enhanced macrophage proliferation when an expression construct containing PU.1 minus the PEST domain was transfected into bone marrow-derived macrophages.	Proline	10-17	Spi-1 proto-oncogene	Homo sapiens	88-92
8668214-4	1996	The results showed that AML1 is phosphorylated in vivo on two serine residues within the proline-, serine-, and threonine-rich region, with dependence on the activation of extracellular signal-regulated kinase (ERK) and with interleukin-3 stimulation in a hematopoietic cell line.	Proline	89-96	RUNX family transcription factor 1	Homo sapiens	24-28
8668148-6	1996	Through immunoprecipitation and two-hybrid analysis, we demonstrate a direct physical interaction between HEF1 and p130cas, as well as an interaction of the SH3 domain of HEF1 with two discrete proline-rich regions of focal adhesion kinase.	Proline	194-201	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	171-175
8668214-4	1996	The results showed that AML1 is phosphorylated in vivo on two serine residues within the proline-, serine-, and threonine-rich region, with dependence on the activation of extracellular signal-regulated kinase (ERK) and with interleukin-3 stimulation in a hematopoietic cell line.	Proline	89-96	mitogen-activated protein kinase 1	Homo sapiens	211-214
8754212-2	1996	While certain VCS genes coding for proline-rich proteins (hPR-PB, mMSG1, rPR-VB1) are conserved in primates and rodents, others seem to be specific to certain genera.	Proline	35-42	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	Mus musculus	66-71
8766001-0	1996	The regulation of L-proline transport by insulin-like growth factor-I in human osteoblast-like SaOS-2 cells.	Proline	18-27	insulin like growth factor 1	Homo sapiens	41-69
8819159-7	1996	This movement can be correlated with the mutation of Leu 17 to Val and Ala 47 to Pro in TGF-beta 3.	Proline	81-84	transforming growth factor beta 3	Homo sapiens	88-98
8766001-1	1996	The effect of insulin-like growth factor-I on amino acid transport was studied by measuring the uptake of tritiated L-proline in the cultured human osteoblast-like SaOS-2 cells.	Proline	116-125	insulin like growth factor 1	Homo sapiens	14-42
8766001-2	1996	The uptake of L-proline was supported by both transport system A, ASC and Gly and by Na+-dependent amino acid transport system A, and by Na+-independent system L. The initial rate of total L-proline uptake as a function of concentration showed saturation and obeyed Michaelis-Menten kinetics with Michaelis constant (Km) and maximum velocity (Vmax) values of 1.87 mM and 8.89 nmol x (mg protein)-1 x (3 min)-1, respectively.	Proline	14-23	PYD and CARD domain containing	Homo sapiens	66-69
8766001-3	1996	Na+-dependent L-proline uptake was significantly stimulated by insulin-like growth factor-I in a time- and concentration-dependent manner.	Proline	14-23	insulin like growth factor 1	Homo sapiens	63-91
8766001-6	1996	The stimulated increment above basal L-proline uptake was completely inhibited by alpha-(methylamino) isobutyric acid, suggesting that only system A was affected by insulin-like growth factor-I.	Proline	37-46	insulin like growth factor 1	Homo sapiens	165-193
8766001-7	1996	Na+-dependent L-proline uptake was also stimulated by insulin-like growth factor-II and insulin-like growth factor-I analogues.	Proline	14-23	insulin like growth factor 2	Homo sapiens	54-116
8766001-8	1996	The insulin-like growth factor-I-stimulated L-proline uptake was inhibited by one of its binding protein, insulin-like growth factor binding protein-4, in a concentration-dependent manner.	Proline	44-53	insulin like growth factor 1	Homo sapiens	4-32
8766001-8	1996	The insulin-like growth factor-I-stimulated L-proline uptake was inhibited by one of its binding protein, insulin-like growth factor binding protein-4, in a concentration-dependent manner.	Proline	44-53	insulin like growth factor binding protein 4	Homo sapiens	106-150
8663008-0	1996	Contribution of proline residues in the membrane-spanning domains of cystic fibrosis transmembrane conductance regulator to chloride channel function.	Proline	16-23	CF transmembrane conductance regulator	Homo sapiens	69-120
8663008-2	1996	In the cystic fibrosis transmembrane conductance regulator (CFTR), the predicted transmembrane segments contain four prolines: Pro99, Pro205, Pro324, and Pro1021.	Proline	117-125	CF transmembrane conductance regulator	Homo sapiens	7-58
8663008-2	1996	In the cystic fibrosis transmembrane conductance regulator (CFTR), the predicted transmembrane segments contain four prolines: Pro99, Pro205, Pro324, and Pro1021.	Proline	117-125	CF transmembrane conductance regulator	Homo sapiens	60-64
8663008-12	1996	These results suggest that proline residues in the transmembrane segments are important for CFTR function, Pro205 is critical for correct protein processing, and Pro99 may contribute either directly or indirectly to the Cl- channel pore.	Proline	27-34	CF transmembrane conductance regulator	Homo sapiens	92-96
8670803-5	1996	The inclusion of peptides encompassing an hSos1 proline-rich motif in cell lysates resulted in enhanced binding of RPTPalpha to GRB2 in vitro, suggesting that steric hindrance prohibits formation of the RPTPalpha-GRB2-Sos complex.	Proline	48-55	protein tyrosine phosphatase receptor type A	Homo sapiens	115-124
8670173-6	1996	Polymeric pig colonic mucin comprised 16% protein per mg of glycoprotein and was rich in serine, threonine and proline (43% of total amino acids).	Proline	111-118	LOC100508689	Homo sapiens	22-27
8679575-1	1996	Upon addition of calcium to the metal-free protein, bovine prothrombin displays a conformational change with behavior of a classic trans- to cis-proline isomerization.	Proline	145-152	coagulation factor II, thrombin	Bos taurus	59-70
8679575-10	1996	This proline is of the trans configuration in a crystallized form of calcium-bovine prothrombin fragment 1 [Soriano-Garcia, M., et al.	Proline	5-12	coagulation factor II, thrombin	Bos taurus	84-95
8679575-14	1996	Proline 22 in bovine prothrombin may constitute a useful biochemical marker for the membrane-binding conformation of a vitamin K-dependent protein.	Proline	0-7	coagulation factor II, thrombin	Bos taurus	21-32
8670803-5	1996	The inclusion of peptides encompassing an hSos1 proline-rich motif in cell lysates resulted in enhanced binding of RPTPalpha to GRB2 in vitro, suggesting that steric hindrance prohibits formation of the RPTPalpha-GRB2-Sos complex.	Proline	48-55	growth factor receptor bound protein 2	Homo sapiens	128-132
8652539-4	1996	The mass of both fractions by mass spectral analysis was 22 721 daltons, and N-terminal amino acid sequences were identical to the first four amino acids of apo A-I (Asp, Glu, Pro, Pro).	Proline	176-179	apolipoprotein A1	Homo sapiens	157-164
8660922-6	1996	Transcriptional activation required the AP-2.2 amino-terminal region that contains a domain rich in proline and glutamine residues.	Proline	100-107	transcription factor AP-2 alpha	Homo sapiens	40-44
8652539-4	1996	The mass of both fractions by mass spectral analysis was 22 721 daltons, and N-terminal amino acid sequences were identical to the first four amino acids of apo A-I (Asp, Glu, Pro, Pro).	Proline	181-184	apolipoprotein A1	Homo sapiens	157-164
8652525-2	1996	In the present study, we have evaluated the effect of substitution, with a proline, at positions P5, P7, P14, P15, or P16, on the conformational flexibility and functional properties of PAI-1.	Proline	75-82	serpin family E member 1	Homo sapiens	186-191
8661376-0	1996	A potential proline-rich motif upstream of the immunoreceptor tyrosine-based activation motif in bovine leukemia virus gp30, Epstein-Barr virus LMP2A, herpesvirus papio LMP2A, and African horsesickness virus VP7.	Proline	12-19	LMP2A	Human gammaherpesvirus 4	144-149
8649776-2	1996	By using recombination PCR in vitro mutagenesis, we introduced point mutations into the codon 273 of wild-type (wt) p53 (pC53-SN3) from Arg to His (pC53-273H [273H]), Asp (273D), Pro (273P), Lys (273K), Leu (273L) or Thr (273T), and compared their biological and biochemical activities with wt p53 and cancer-derived 175H, 248W and 273H/309S.	Proline	179-182	tumor protein p53	Homo sapiens	116-119
8650211-0	1996	PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47 phox.	Proline	9-16	pleckstrin	Homo sapiens	131-134
8650211-7	1996	Its effects involve both a polybasic amino-terminal segment and a proline-rich core region of PR-39 that binds to the p47phox Src homology 3 domains and, thereby, inhibits interaction with the small subunit of cytochrome b558, p22phox.	Proline	66-73	neutrophil cytosolic factor 1	Homo sapiens	118-125
8650211-7	1996	Its effects involve both a polybasic amino-terminal segment and a proline-rich core region of PR-39 that binds to the p47phox Src homology 3 domains and, thereby, inhibits interaction with the small subunit of cytochrome b558, p22phox.	Proline	66-73	mitochondrially encoded cytochrome b	Homo sapiens	210-222
8650211-7	1996	Its effects involve both a polybasic amino-terminal segment and a proline-rich core region of PR-39 that binds to the p47phox Src homology 3 domains and, thereby, inhibits interaction with the small subunit of cytochrome b558, p22phox.	Proline	66-73	cytochrome b-245 alpha chain	Homo sapiens	227-234
8649768-2	1996	IsfI and IsfII nucleotide sequences differ only by the presence in IsfII of an inframe 45 hp insertion located near the first proline-rich motif required for Grb2 binding.	Proline	126-133	growth factor receptor bound protein 2	Homo sapiens	158-162
8662921-1	1996	p130(Cas) (crk associated substrate) has the structural characteristics of an adapter protein, containing multiple consensus SH2 binding sites, an SH3 domain, and a proline-rich domain.	Proline	165-172	BCAR1 scaffold protein, Cas family member	Homo sapiens	0-9
8662921-6	1996	We show that the association of p130(Cas) with pp125(Fak) and pp41/43(FRNK) is direct, and is mediated by the binding of the SH3 domain of p130(Cas) to a proline-rich sequence present in both the C terminus of pp125(FAK) and in pp41/43(FRNK).	Proline	154-161	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	32-36
8662921-6	1996	We show that the association of p130(Cas) with pp125(Fak) and pp41/43(FRNK) is direct, and is mediated by the binding of the SH3 domain of p130(Cas) to a proline-rich sequence present in both the C terminus of pp125(FAK) and in pp41/43(FRNK).	Proline	154-161	protein tyrosine kinase 2	Homo sapiens	53-56
8662921-6	1996	We show that the association of p130(Cas) with pp125(Fak) and pp41/43(FRNK) is direct, and is mediated by the binding of the SH3 domain of p130(Cas) to a proline-rich sequence present in both the C terminus of pp125(FAK) and in pp41/43(FRNK).	Proline	154-161	protein tyrosine kinase 2	Homo sapiens	70-74
8662921-6	1996	We show that the association of p130(Cas) with pp125(Fak) and pp41/43(FRNK) is direct, and is mediated by the binding of the SH3 domain of p130(Cas) to a proline-rich sequence present in both the C terminus of pp125(FAK) and in pp41/43(FRNK).	Proline	154-161	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	139-143
8662921-6	1996	We show that the association of p130(Cas) with pp125(Fak) and pp41/43(FRNK) is direct, and is mediated by the binding of the SH3 domain of p130(Cas) to a proline-rich sequence present in both the C terminus of pp125(FAK) and in pp41/43(FRNK).	Proline	154-161	protein tyrosine kinase 2	Homo sapiens	216-219
8662921-6	1996	We show that the association of p130(Cas) with pp125(Fak) and pp41/43(FRNK) is direct, and is mediated by the binding of the SH3 domain of p130(Cas) to a proline-rich sequence present in both the C terminus of pp125(FAK) and in pp41/43(FRNK).	Proline	154-161	protein tyrosine kinase 2	Homo sapiens	236-240
8661930-4	1996	PAL-1 also used proline, hydrogen, lactate, propionate, succinate, fumarate, pyruvate, or yeast extract as electron donors for Fe(III) reduction.	Proline	16-23	Pal1p	Saccharomyces cerevisiae S288C	0-5
8674537-1	1996	PHF-tau, which is phosphorylated at 10 Ser/Thr-Pro and 11 non-Ser/Thr-Pro sites, is unable to promote microtubule assembly.	Proline	47-50	microtubule associated protein tau	Homo sapiens	0-7
8674537-1	1996	PHF-tau, which is phosphorylated at 10 Ser/Thr-Pro and 11 non-Ser/Thr-Pro sites, is unable to promote microtubule assembly.	Proline	70-73	microtubule associated protein tau	Homo sapiens	0-7
8764147-3	1996	Immediately after transfection with E51 cDNA, both alpha-aminoisobutyric acid (AIB) and proline uptake in the mutated yeast were increased, particularly at pH 5.	Proline	88-95	RNA binding protein with serine rich domain 1	Homo sapiens	36-39
8641215-7	1996	Pro-LHRH levels in lysate and medium were depressed by phorbol esters; concentrations in bFGF-treated cells were somewhat lower than those in unstimulated controls.	Proline	0-3	gonadotropin releasing hormone 1	Mus musculus	4-8
8666171-2	1996	The hypothesis is based on the assumption that the proline hinge domain of interstitial collagenase adopts a collagen-like conformation.	Proline	51-58	matrix metallopeptidase 1	Homo sapiens	75-99
8647212-5	1996	Using MOLT-4 transfectants with the mutant beta chains, we found that two conserved proline residues within the box 1 region are essentially involved in association with Jak1.	Proline	84-91	Janus kinase 1	Homo sapiens	170-174
8647857-7	1996	A combination of two mutations, Ile99 --&gt; His and Ser200 --&gt; Pro, converted P450 2C9 to an enzyme with a turnover number of omeprazole 5-hyrdroxylation, which resembled that of P450 /c19.	Proline	67-70	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	82-86
8822580-0	1996	First case of sporadic protein S deficiency due to a novel candidate mutation, Ala 484--&gt;Pro, in the protein S active gene (PROS1).	Proline	92-95	protein S	Homo sapiens	127-132
8647857-7	1996	A combination of two mutations, Ile99 --&gt; His and Ser200 --&gt; Pro, converted P450 2C9 to an enzyme with a turnover number of omeprazole 5-hyrdroxylation, which resembled that of P450 /c19.	Proline	67-70	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	183-187
8662772-5	1996	Using a degenerate phosphopeptide library screen, we show that the PTB domain of ShcC preferentially binds the sequence His-hydrophobic-Asn/hydrophobic-Asn-Pro-Ser/Thr-Tyr(P).	Proline	156-159	SHC adaptor protein 3	Homo sapiens	81-85
8664340-5	1996	Treatment with STC1-20 (10(-11)-10(-13) M) caused increases of the rate of incorporation of [3H]proline into the collagenase-digestible protein of calvariae in newborn mice.	Proline	96-103	stanniocalcin 1	Mus musculus	15-22
8647806-3	1996	Thr-439, in the IL-2 receptor binding domain of the fusion toxin, was changed to a Pro residue.	Proline	83-86	interleukin 2 receptor subunit beta	Homo sapiens	16-29
8645165-0	1996	Multiple cis-trans conformers of the prolactin receptor proline-rich motif (PRM) peptide detected by reverse-phase HPLC, CD and NMR spectroscopy.	Proline	56-63	prolactin receptor	Homo sapiens	37-55
8657566-7	1996	Further, the transactivation domain of hXBP-1 encompasses a large C-terminal region of the protein, containing domains rich in glutamine, serine and threonine, and proline and glutamine residues, as shown in transient transfection experiments using hXBP-1-GAL4 fusion proteins and a reporter gene under the control of GAL4-binding sites.	Proline	164-171	X-box binding protein 1	Homo sapiens	39-45
8634183-1	1996	NMR studies have been used to examine conformational effects in thyrotropin-releasing hormone (TRH), the epimer incorporating D-His, and their analogues where trans- and cis-4-hydroxy-L-proline replace L-proline (Pro).	Proline	184-193	thyrotropin releasing hormone	Homo sapiens	64-93
8634183-1	1996	NMR studies have been used to examine conformational effects in thyrotropin-releasing hormone (TRH), the epimer incorporating D-His, and their analogues where trans- and cis-4-hydroxy-L-proline replace L-proline (Pro).	Proline	184-193	thyrotropin releasing hormone	Homo sapiens	95-98
8703438-3	1996	Cleavage of IgA1 by these post-proline endopeptidases efficiently separates the monomeric antigen-binding fragments from the secondary effector functions of the IgA1 antibody molecule.	Proline	31-38	immunoglobulin heavy constant alpha 1	Homo sapiens	12-16
8703438-3	1996	Cleavage of IgA1 by these post-proline endopeptidases efficiently separates the monomeric antigen-binding fragments from the secondary effector functions of the IgA1 antibody molecule.	Proline	31-38	immunoglobulin heavy constant alpha 1	Homo sapiens	161-165
8665844-0	1996	WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle"s syndrome.	Proline	32-39	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	14-19
8665844-9	1996	Nedd4-WW domains also bound to the proline-rich C-terminus (containing the sequence PPPAY) of alpharENaC, and endogenous Nedd4 co-immunoprecipitated with alpharENaC expressed in MDCK cells.	Proline	35-42	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	0-5
8649853-7	1996	Analysis of the mechanism of association indicated that the ArgBP1 SH3 domain binds to a C-terminal Arg SH3-binding site, and that an N-terminal ArgBP1 proline-rich sequence binds to the Arg SH3 domain.	Proline	152-159	abl interactor 2	Homo sapiens	145-151
8649853-9	1996	The similarity of the ArgBP1 expression pattern and subcellular localization to those of Arg and the potential for a highly specific and potentially strong association mediated by two pairs of SH3 domain/proline-rich motif interactions, suggest that ArgBP1 is likely to be a regulator and/or effector of Arg function.	Proline	204-211	abl interactor 2	Homo sapiens	250-256
8624253-1	1996	Small proline-rich proteins, believed to be precursor proteins for the crosslinked envelope formation in cells undergoing squamous differentiation, are encoded by the SPRR genes.	Proline	6-13	small proline-rich protein 1A	Rattus norvegicus	167-171
8645165-6	1996	The cis:trans ratio for each proline in water, calculated from integrated intensities and/or peak heights of the appropriate resonances, were Phe2-Pro3 (35:65), Pro3-Pro4 (40:60), Val5-Pro6 (70:30), and Gly7-Pro8 (30:70).	Proline	29-36	pyrroline-5-carboxylate reductase 1	Homo sapiens	147-151
8645165-6	1996	The cis:trans ratio for each proline in water, calculated from integrated intensities and/or peak heights of the appropriate resonances, were Phe2-Pro3 (35:65), Pro3-Pro4 (40:60), Val5-Pro6 (70:30), and Gly7-Pro8 (30:70).	Proline	29-36	pyrroline-5-carboxylate reductase 1	Homo sapiens	161-165
8609497-4	1996	With a MAb directed against the Trp-Trp322-Pro (WWP) motif of EBNA-2, which is known to be essential for the interaction of EBNA-2 with the cellular factor RBPJkappa/CBF1, we could inhibit the DNA binding of EBNA-2, providing further evidence that this region of EBNA-2 forms direct contact with RBPJkappa/CBF1.	Proline	43-46	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	156-165
9162298-3	1996	A germline polymorphism of p53 with a single-base change at codon 72 that causes an amino acid replacement of arginine (Arg; CGC) by proline (PRO; CCC) has also been reported to be associated with cancer susceptibility in a Japanese population.	Proline	133-140	tumor protein p53	Homo sapiens	27-30
9162298-3	1996	A germline polymorphism of p53 with a single-base change at codon 72 that causes an amino acid replacement of arginine (Arg; CGC) by proline (PRO; CCC) has also been reported to be associated with cancer susceptibility in a Japanese population.	Proline	142-145	tumor protein p53	Homo sapiens	27-30
8666671-5	1996	Boi2p has a proline-rich sequence that is critical for displaying the Boi2p-Bem1p two-hybrid interaction, an SH3 domain in its NH2-terminal half, and a pleckstrin homology domain in its COOH-terminal half.	Proline	12-19	Boi2p	Saccharomyces cerevisiae S288C	0-5
8666671-5	1996	Boi2p has a proline-rich sequence that is critical for displaying the Boi2p-Bem1p two-hybrid interaction, an SH3 domain in its NH2-terminal half, and a pleckstrin homology domain in its COOH-terminal half.	Proline	12-19	Boi2p	Saccharomyces cerevisiae S288C	70-75
8666671-5	1996	Boi2p has a proline-rich sequence that is critical for displaying the Boi2p-Bem1p two-hybrid interaction, an SH3 domain in its NH2-terminal half, and a pleckstrin homology domain in its COOH-terminal half.	Proline	12-19	phosphatidylinositol-3-phosphate-binding protein BEM1	Saccharomyces cerevisiae S288C	76-81
8609497-4	1996	With a MAb directed against the Trp-Trp322-Pro (WWP) motif of EBNA-2, which is known to be essential for the interaction of EBNA-2 with the cellular factor RBPJkappa/CBF1, we could inhibit the DNA binding of EBNA-2, providing further evidence that this region of EBNA-2 forms direct contact with RBPJkappa/CBF1.	Proline	43-46	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	166-170
8609497-4	1996	With a MAb directed against the Trp-Trp322-Pro (WWP) motif of EBNA-2, which is known to be essential for the interaction of EBNA-2 with the cellular factor RBPJkappa/CBF1, we could inhibit the DNA binding of EBNA-2, providing further evidence that this region of EBNA-2 forms direct contact with RBPJkappa/CBF1.	Proline	43-46	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	296-305
8609497-4	1996	With a MAb directed against the Trp-Trp322-Pro (WWP) motif of EBNA-2, which is known to be essential for the interaction of EBNA-2 with the cellular factor RBPJkappa/CBF1, we could inhibit the DNA binding of EBNA-2, providing further evidence that this region of EBNA-2 forms direct contact with RBPJkappa/CBF1.	Proline	43-46	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	306-310
8725894-1	1996	Glycogen synthase kinase (GSK) 3 alpha and 3 beta are two proline-directed serine/ threonine kinases that have been shown in vitro to hyperphosphorylate tau, and therefore, may contribute to neurofibillary tangle (NFT) formation in Alzheimer"s disease (AD).	Proline	58-65	glycogen synthase kinase 3 alpha	Homo sapiens	0-49
8725894-1	1996	Glycogen synthase kinase (GSK) 3 alpha and 3 beta are two proline-directed serine/ threonine kinases that have been shown in vitro to hyperphosphorylate tau, and therefore, may contribute to neurofibillary tangle (NFT) formation in Alzheimer"s disease (AD).	Proline	58-65	microtubule associated protein tau	Homo sapiens	153-156
8630004-5	1996	It contains an insert of ten amino acids located within a region corresponding to the fourth proline-rich basic domain of p130 alpha.	Proline	93-100	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	122-126
8633057-11	1996	SNAP45 is exceptionally proline-rich, interacts strongly with TBP, and, like SNAP43, is required for both RNA polymerase II and III transcription of snRNA genes.	Proline	24-31	small nuclear RNA activating complex polypeptide 2	Homo sapiens	0-6
8621661-1	1996	Delta 1-pyrroline-5-carboxylate dehydrogenase (P5CDh; EC 1.5.1.12), a mitochondrial matrix NAD(+)-dependent dehydrogenase, catalyzes the second step of the proline degradation pathway.	Proline	156-163	aldehyde dehydrogenase 4 family member A1	Homo sapiens	47-52
8626633-2	1996	In the present study, the hypothesis that proline-directed kinases play a major role in phosphorylating cytidylyltransferase is substantiated using a c-Ha-ras-transfected clone of the human keratinocyte cell line HaCaT.	Proline	42-49	transcription factor like 5	Homo sapiens	150-154
8621623-9	1996	The TEF-1 proline-rich domain was essential for TBP binding, but polypeptides also containing the zinc finger domain bound TBP with higher apparent affinity.	Proline	10-17	TEA domain transcription factor 1	Homo sapiens	4-9
8621623-9	1996	The TEF-1 proline-rich domain was essential for TBP binding, but polypeptides also containing the zinc finger domain bound TBP with higher apparent affinity.	Proline	10-17	TATA-box binding protein	Homo sapiens	48-51
8621623-9	1996	The TEF-1 proline-rich domain was essential for TBP binding, but polypeptides also containing the zinc finger domain bound TBP with higher apparent affinity.	Proline	10-17	TATA-box binding protein	Homo sapiens	123-126
8626627-6	1996	Importantly, a transcription-defective VP16 minimal activation domain (amino acids 413-453) mutated at critical residue 442 (phenylalanine --&gt; proline) maintained synergism, when bound to RNA, with the DNA-bound wild-type VP16 minimal activation domain.	Proline	146-153	host cell factor C1	Homo sapiens	39-43
8626627-6	1996	Importantly, a transcription-defective VP16 minimal activation domain (amino acids 413-453) mutated at critical residue 442 (phenylalanine --&gt; proline) maintained synergism, when bound to RNA, with the DNA-bound wild-type VP16 minimal activation domain.	Proline	146-153	host cell factor C1	Homo sapiens	225-229
8621599-6	1996	Using peptides corresponding to J-domain sequence, we show that a peptide containing the highly conserved His-Pro-Asp sequence at positions 34-36 in the J-domain competes off YDJ1 stimulation of Hsp70 ATPase activity.	Proline	110-113	type I HSP40 co-chaperone YDJ1	Saccharomyces cerevisiae S288C	175-179
8617244-3	1996	In vitro mutagenesis and transient transfection experiments indicate that the C-terminal serine/threonine/proline-rich region of BSAP contains a potent transactivation domain of 55 amino acids which is active from promoter and enhancer positions.	Proline	106-113	paired box 5	Homo sapiens	129-133
8648633-9	1996	The structure reveals that the lost ability of des-[Phe(B25)] insulin to self-associate is caused by a conformational change of the C-terminal region of the B-chain, which results in an intra-molecular hydrophobic interaction between Pro(B28) and the hydrophobic region Leu(B11)-Leu(B15) of the B-chain alpha-helix.	Proline	234-237	insulin	Homo sapiens	62-69
8622875-3	1996	Solution binding and two-hybrid system experiments demonstrate that association of Vav with the LIM domain protein zyxin is mediated by the C-terminal SH3 domain of the Vav and involves the proline-rich N-terminus of zyxin.	Proline	190-197	vav guanine nucleotide exchange factor 1	Homo sapiens	83-86
8622875-3	1996	Solution binding and two-hybrid system experiments demonstrate that association of Vav with the LIM domain protein zyxin is mediated by the C-terminal SH3 domain of the Vav and involves the proline-rich N-terminus of zyxin.	Proline	190-197	zyxin	Homo sapiens	115-120
8622875-3	1996	Solution binding and two-hybrid system experiments demonstrate that association of Vav with the LIM domain protein zyxin is mediated by the C-terminal SH3 domain of the Vav and involves the proline-rich N-terminus of zyxin.	Proline	190-197	zyxin	Homo sapiens	217-222
8786430-3	1996	In contrast, a Tat protein that contained a deletion of the proline-rich domain promoted neuronal aggregation.	Proline	60-67	tyrosine aminotransferase	Homo sapiens	15-18
8648633-9	1996	The structure reveals that the lost ability of des-[Phe(B25)] insulin to self-associate is caused by a conformational change of the C-terminal region of the B-chain, which results in an intra-molecular hydrophobic interaction between Pro(B28) and the hydrophobic region Leu(B11)-Leu(B15) of the B-chain alpha-helix.	Proline	234-237	NADH:ubiquinone oxidoreductase subunit B4	Homo sapiens	279-286
8846888-0	1996	Functional analysis of the PUT3 transcriptional activator of the proline utilization pathway in Saccharomyces cerevisiae.	Proline	65-72	Put3p	Saccharomyces cerevisiae S288C	27-31
8846888-2	1996	PUT3, the activator of the proline utilization pathway, is required for the transcription of the genes encoding the enzymes that convert proline to glutamate.	Proline	27-34	Put3p	Saccharomyces cerevisiae S288C	0-4
8846888-2	1996	PUT3, the activator of the proline utilization pathway, is required for the transcription of the genes encoding the enzymes that convert proline to glutamate.	Proline	137-144	Put3p	Saccharomyces cerevisiae S288C	0-4
8846888-5	1996	Biochemical and molecular tests, domain swapping experiments, and an analysis of activator-constitutive and activator-defective mutant proteins indicate that PUT3 is dimeric and activates transcription with its negatively charged carboxyterminus, which does not appear to contain a proline-responsive domain.	Proline	282-289	Put3p	Saccharomyces cerevisiae S288C	158-162
8780101-9	1996	This transition causes a Ser to Pro mutation in the major extracellular loop of PLP/DM20.	Proline	32-35	proteolipid protein 1	Homo sapiens	80-88
8670737-2	1996	It encodes a predicted 180 residue, 20546 Da secreted protein, with a charge of +11 at ph 7 and 24.5% proline, designated as Basic Proline-rich Lacrimal Protein (BPLP), Southern blot analysis is consistent with a single BPLP gene.	Proline	102-109	opiorphin prepropeptide	Homo sapiens	125-160
9026355-1	1996	Prolyl endopeptidase has been predominantly described as a cytosolic activity capable of cleaving a number of important neuropeptides (including TRH, LHRH, Bradykinin, Angiotensin, Substance P, Neurotensin, Oxytocin and Vasopressin) on the carboxy side of proline.	Proline	256-263	prolyl endopeptidase	Bos taurus	0-20
8743562-7	1996	The N-terminal amino acid sequence of MTSP-1 was Ile-Val-Gly-Gly-Tyr-Thr-His-Leu-Asp-Asn-Gln-Val-Pro-Tyr.	Proline	97-100	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	38-44
8666952-2	1996	The primary sequence of SLP-76 predicts a protein of 533 amino acids comprising an amino-terminal region with numerous potential tyrosine phosphorylation sites, a central region rich in proline residues, and a single carboxy-terminal SH2 domain.	Proline	186-193	lymphocyte cytosolic protein 2	Homo sapiens	24-30
8642676-2	1996	EBNA3C consists of 992 amino acids and includes a potential bZIP motif and regions rich in acidic, proline, and glutamine residues.	Proline	99-106	EBNA-3C	Human gammaherpesvirus 4	0-6
8642676-11	1996	A fragment of EBNA3C (amino acids 280 to 525) which represses expression in a manner which is nearly identical to that of the full-length protein has been identified; this fragment is rich in acidic and proline residues.	Proline	203-210	EBNA-3C	Human gammaherpesvirus 4	14-20
8632427-12	1996	The localization of the Pro residue of 22 outside the NEP active site is supported by biochemical data using (Arg102,Glu)NEP and molecular modeling studies with thermolysin used as model of NEP.	Proline	24-27	membrane metallo endopeptidase	Mus musculus	54-57
8626407-8	1996	Overall, equilibrium reactions involving the nuclear localizing sequence, the proline-rich SH3 binding motif, and the phosphorylation state of 5-lipoxygenase may each influence its partnership with other cellular proteins and any novel functions derived from such partnerships.	Proline	78-85	arachidonate 5-lipoxygenase	Homo sapiens	143-157
8624437-3	1996	Many aquaporins are mercury sensitive, and in AQP1, a mercury-sensitive cysteine residue (Cys-189) is present adjacent to a conserved Asn-Pro-Ala motif.	Proline	138-141	aquaporin 1 (Colton blood group)	Homo sapiens	46-50
8626429-6	1996	A functional proline-rich motif and the tyrosine phosphorylation of Nef were evidenced as likely participants in this interaction.	Proline	13-20	S100 calcium binding protein B	Homo sapiens	68-71
8632427-12	1996	The localization of the Pro residue of 22 outside the NEP active site is supported by biochemical data using (Arg102,Glu)NEP and molecular modeling studies with thermolysin used as model of NEP.	Proline	24-27	membrane metallo endopeptidase	Mus musculus	121-124
8632427-12	1996	The localization of the Pro residue of 22 outside the NEP active site is supported by biochemical data using (Arg102,Glu)NEP and molecular modeling studies with thermolysin used as model of NEP.	Proline	24-27	membrane metallo endopeptidase	Mus musculus	121-124
8761662-0	1996	Database cloning human delta 1-pyrroline-5-carboxylate synthetase (P5CS) cDNA: a bifunctional enzyme catalyzing the first 2 steps in proline biosynthesis.	Proline	133-140	aldehyde dehydrogenase 18 family member A1	Homo sapiens	23-65
8984196-4	1996	Identification of proline as N-terminal amino acid of the purified protein suggests post-translational modification of CD9 in the rat central nervous system.	Proline	18-25	CD9 molecule	Rattus norvegicus	119-122
8649813-4	1996	The Mader protein of approximately 55 kD has two proline rich domains and contains 15 potential phosphorylation sites, a nuclear localization signal, and multiple S(T)PXX motifs that are characteristic of regulatory DNA binding proteins.	Proline	49-56	NGFI-A binding protein 2	Homo sapiens	4-9
8621459-4	1996	The mitogen-activated protein kinase (MAPK) phosphorylated hSOS1 in vitro within the carboxyl-terminal proline-rich domain.	Proline	103-110	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	59-64
8761662-0	1996	Database cloning human delta 1-pyrroline-5-carboxylate synthetase (P5CS) cDNA: a bifunctional enzyme catalyzing the first 2 steps in proline biosynthesis.	Proline	133-140	aldehyde dehydrogenase 18 family member A1	Homo sapiens	67-71
8761662-1	1996	delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	Proline	194-201	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-42
8761662-1	1996	delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	Proline	194-201	aldehyde dehydrogenase 18 family member A1	Homo sapiens	44-48
8761662-1	1996	delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	Proline	194-201	GNAS complex locus	Homo sapiens	123-156
8761662-5	1996	The phenotypic features for deficiency of P5CS include joint hyperlaxity, skin hyperelasticity, cataract and mental retardation with hyperammonemia and low plasma levels of proline, citrulline and ornithine.	Proline	173-180	aldehyde dehydrogenase 18 family member A1	Homo sapiens	42-46
8805247-7	1996	Peptides presented by HLA-G usually consisted of 9 amino acids, and adhered to a specific sequence motif, with anchor residues at position 2 (isoleucine or leucine), position 3 (proline) and the carboxy-terminal position 9 (leucine).	Proline	178-185	major histocompatibility complex, class I, G	Homo sapiens	22-27
8603920-4	1996	We found that a change to a proline residue in a potential coiled-coil region of Spc42p was responsible for the ts phenotype in at least three alleles, suggesting that formation of the coiled-coil is essential in normal function.	Proline	28-35	Spc42p	Saccharomyces cerevisiae S288C	81-87
8635738-6	1996	268 (1993) 23025-23030] using a library displaying random peptides 15 aa in length identified CaM-binding peptides which contained a Trp-Pro dipeptide motif.	Proline	137-140	calmodulin 1	Homo sapiens	94-97
8617744-6	1996	Alteration of the Asn or Pro to Ala in the NPXpY motif of the EGFR Tyr-1148 peptide increased the KD of PI domain interactions to 238 and 370 nM, respectively.	Proline	25-28	epidermal growth factor receptor	Homo sapiens	62-66
8769848-6	1996	Substitution of a leucine for a proline at position 327 in tyrosine hydroxylase produces a molecule with a K(m) for tetrahydrobiopterin 20-fold higher than that of the wild-type molecule, whereas the same substitution at the corresponding residue in phenylalanine hydroxylase (pro281) has no effect on the kinetic constant for the cofactor.	Proline	32-39	phenylalanine hydroxylase	Rattus norvegicus	250-275
8605874-6	1996	Furthermore, we find that the WWP/WW domain can compete with the Abl SH3 domain in binding a proline-rich peptide present in formin.	Proline	93-100	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	65-68
8632913-5	1996	Like Ack, Tnk1 consists of an N-terminal kinase domain, a putative SH3 domain immediately C-terminal to the kinase domain, and a proline-rich C-terminal region.	Proline	129-136	tyrosine kinase non receptor 1	Homo sapiens	10-14
8632892-3	1996	The carboxyl-terminal half of Tob is characterized by the presence of a sequence rich in proline and glutamine and shows no homology to known proteins.	Proline	89-96	transducer of ErbB-2.1	Mus musculus	30-33
8605036-6	1996	This deletion, which may arise from anomalous splicing of heteronuclear RNA, is likely to influence formation of the ALK-5:type II receptor complex through conformational changes associated with removal of a putative hinge region containing proline.	Proline	241-248	transforming growth factor beta receptor 1	Homo sapiens	117-122
8632015-3	1996	Deduced from the nucleotide sequences of cDNA, DREF is a polypeptide of 701 amino acid residues with a molecular weight of 80,096, which contains three characteristic regions, rich in basic amino acids, proline, and acidic amino acids, respectively.	Proline	203-210	DNA replication-related element factor	Drosophila melanogaster	47-51
8838315-7	1996	The amino-terminal end of the GBX2 protein is proline-rich, with 30 proline residues in one stretch of 120 amino acids.	Proline	46-53	gastrulation brain homeobox 2	Homo sapiens	30-34
8647313-2	1996	The two amino acid substitutions, a valine to phenylalanine and a leucine to proline, occur at positions 581 and 616, respectively, of the androgen receptor.	Proline	77-84	androgen receptor	Homo sapiens	139-156
8625447-1	1996	The p53 tumor suppressor gene is often mutated in various human cancers and a common polymorphism is known at codon 72 of exon 4, with two alleles encoding either arginine (CGC) or proline (CCC).	Proline	181-188	tumor protein p53	Homo sapiens	4-7
8654390-6	1996	MTB-Zf possesses other structural features characteristic of transcription factors, including a long stretch of acidic amino acids (amino acids 67 - 95), a proline-rich region (positions 733-849), a region rich in basic amino acids (positions 1161-1247), and a leucine repeat-like region (positions 486-514).	Proline	156-163	PR/SET domain 2	Homo sapiens	0-6
8603751-3	1996	By substituting the N-terminal alanine of the substrates with proline, the catalytic efficiency of the enzymic reaction, by the serine proteases, is diminished by 2-3 orders of magnitude, whereas that by neprilysin and theromlysin decreases only slightly.	Proline	62-69	membrane metalloendopeptidase	Homo sapiens	204-214
8634286-0	1996	Folding and unfolding kinetics of the proline-to-alanine mutants of bovine pancreatic ribonuclease A.	Proline	38-45	ribonuclease pancreatic	Bos taurus	86-100
8634286-4	1996	Single-jump folding, single-jump unfolding, and double-jump unfolding/folding stopped-flow experiments were carried out on wild-type and the four proline mutants of RNase A using absorption detection to follow the folding kinetics.	Proline	146-153	ribonuclease pancreatic	Bos taurus	165-172
8838315-7	1996	The amino-terminal end of the GBX2 protein is proline-rich, with 30 proline residues in one stretch of 120 amino acids.	Proline	68-75	gastrulation brain homeobox 2	Homo sapiens	30-34
8882725-3	1996	RAE-1 protein apparently consists of 253 amino acids and is likely to be a glycoprotein consisting of a leader sequence, an extracellular domain, a serine, threonine, proline-rich domain, and a transmembrane domain.	Proline	167-174	ribonucleic acid export 1	Mus musculus	0-5
8671609-0	1996	Critical proline residues of the cytoplasmic domain of the IL-5 receptor alpha chain and its function in IL-5-mediated activation of JAK kinase and STAT5.	Proline	9-16	interleukin 5	Homo sapiens	59-63
8671609-0	1996	Critical proline residues of the cytoplasmic domain of the IL-5 receptor alpha chain and its function in IL-5-mediated activation of JAK kinase and STAT5.	Proline	9-16	interleukin 5	Homo sapiens	105-109
8671609-0	1996	Critical proline residues of the cytoplasmic domain of the IL-5 receptor alpha chain and its function in IL-5-mediated activation of JAK kinase and STAT5.	Proline	9-16	signal transducer and activator of transcription 5A	Homo sapiens	148-153
8671609-4	1996	Mutational analysis revealed that one of the proline residues, particularly Pro352 and Pro355, in the membrane-proximal proline-rich sequence (Pro352-Pro353-X-Pro355) of the cytoplasmic domain of IL-5R alpha is required for cell proliferation, and for both JAK1 and JAK2 activation.	Proline	45-52	interleukin 5 receptor subunit alpha	Homo sapiens	196-207
8671609-4	1996	Mutational analysis revealed that one of the proline residues, particularly Pro352 and Pro355, in the membrane-proximal proline-rich sequence (Pro352-Pro353-X-Pro355) of the cytoplasmic domain of IL-5R alpha is required for cell proliferation, and for both JAK1 and JAK2 activation.	Proline	45-52	Janus kinase 1	Homo sapiens	257-261
8671609-4	1996	Mutational analysis revealed that one of the proline residues, particularly Pro352 and Pro355, in the membrane-proximal proline-rich sequence (Pro352-Pro353-X-Pro355) of the cytoplasmic domain of IL-5R alpha is required for cell proliferation, and for both JAK1 and JAK2 activation.	Proline	45-52	Janus kinase 2	Homo sapiens	266-270
8671609-4	1996	Mutational analysis revealed that one of the proline residues, particularly Pro352 and Pro355, in the membrane-proximal proline-rich sequence (Pro352-Pro353-X-Pro355) of the cytoplasmic domain of IL-5R alpha is required for cell proliferation, and for both JAK1 and JAK2 activation.	Proline	120-127	interleukin 5 receptor subunit alpha	Homo sapiens	196-207
8671609-4	1996	Mutational analysis revealed that one of the proline residues, particularly Pro352 and Pro355, in the membrane-proximal proline-rich sequence (Pro352-Pro353-X-Pro355) of the cytoplasmic domain of IL-5R alpha is required for cell proliferation, and for both JAK1 and JAK2 activation.	Proline	120-127	Janus kinase 1	Homo sapiens	257-261
8671609-4	1996	Mutational analysis revealed that one of the proline residues, particularly Pro352 and Pro355, in the membrane-proximal proline-rich sequence (Pro352-Pro353-X-Pro355) of the cytoplasmic domain of IL-5R alpha is required for cell proliferation, and for both JAK1 and JAK2 activation.	Proline	120-127	Janus kinase 2	Homo sapiens	266-270
8647900-5	1996	The cytoplasmic tail of MDC9 has two proline-rich sequences which can bind the SH3 domain of Src, and may therefore function as SH3 ligand domains.	Proline	37-44	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	Mus musculus	24-28
8647900-5	1996	The cytoplasmic tail of MDC9 has two proline-rich sequences which can bind the SH3 domain of Src, and may therefore function as SH3 ligand domains.	Proline	37-44	Rous sarcoma oncogene	Mus musculus	93-96
8609217-1	1996	Identification of a glutamine to proline substitution that leads to a transport block of sucrase-isomaltase in a pre-Golgi compartment.	Proline	33-40	sucrase-isomaltase	Homo sapiens	89-107
8649453-4	1996	Truncation or substitution of a stretch of a proline rich "hallmark" sequence, "MYPPPY", abrogates binding to CD80 or B70, while retaining CD28 mAb epitopes and cell surface expression.	Proline	45-52	CD80 molecule	Homo sapiens	110-114
8552082-6	1996	Here we report that the proline-rich region of CAP is recognized by the SH3 domains of several proteins, including the yeast actin-associated protein Abp1p.	Proline	24-31	Abp1p	Saccharomyces cerevisiae S288C	150-155
8649453-4	1996	Truncation or substitution of a stretch of a proline rich "hallmark" sequence, "MYPPPY", abrogates binding to CD80 or B70, while retaining CD28 mAb epitopes and cell surface expression.	Proline	45-52	CD28 molecule	Homo sapiens	139-143
8671777-5	1996	The anti-TGF-beta1-3 antibody also partly blocked Ang-II-mediated incorporation of 3[H]proline into de novo synthesized collagens.	Proline	87-94	transforming growth factor, beta 1	Mus musculus	9-18
9005439-1	1996	A pathological variant of human phosphoglycerate kinase, phosphoglycerate kinase-Uppsala, associated with chronic nonspherocytic hemolytic anemia has been found to differ from the normal enzyme by substitution of an arginine at position 206 (corresponding to position 203 in yeast) by a proline.	Proline	287-294	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	32-55
8671777-5	1996	The anti-TGF-beta1-3 antibody also partly blocked Ang-II-mediated incorporation of 3[H]proline into de novo synthesized collagens.	Proline	87-94	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	50-56
8671777-6	1996	Moreover, 5 microM TGF-beta1 antisense oligonucleotides, but not the same concentration of sense oligonucleotides, completely blocked Ang-II-stimulated 3[H]proline incorporation.	Proline	156-163	transforming growth factor, beta 1	Mus musculus	19-28
8671777-6	1996	Moreover, 5 microM TGF-beta1 antisense oligonucleotides, but not the same concentration of sense oligonucleotides, completely blocked Ang-II-stimulated 3[H]proline incorporation.	Proline	156-163	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	134-140
8671777-8	1996	SDS-polyacrylamide electrophoresis of 3[H]proline-labelled collagens and comparison with standard collagens also demonstrated that the neutralizing anti-TGF-1-3 antibody abolished the Ang-II-mediated stimulation in type IV collagen.	Proline	42-49	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	184-190
9005439-1	1996	A pathological variant of human phosphoglycerate kinase, phosphoglycerate kinase-Uppsala, associated with chronic nonspherocytic hemolytic anemia has been found to differ from the normal enzyme by substitution of an arginine at position 206 (corresponding to position 203 in yeast) by a proline.	Proline	287-294	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	57-80
8573103-9	1996	Insertion of a Pro between these two residues, or their substitution by the sequence Gly-Pro-His, caused nearly complete loss of MCP-1 activity.	Proline	15-18	C-C motif chemokine ligand 2	Homo sapiens	129-134
8554050-0	1996	PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins.	Proline	99-106	proline rich protein BstNI subfamily 1	Homo sapiens	0-4
8557636-11	1996	MAGP-2 lacks the proline-, glutamine-, and tyrosine-rich sequences and a hydrophobic carboxyl terminus, characteristic of MAGP-1.	Proline	17-24	microfibril associated protein 5	Homo sapiens	0-6
8550631-6	1996	In addition, Pro-267 is required for JAK-1 binding.	Proline	13-16	Janus kinase 1	Homo sapiens	37-42
8554050-0	1996	PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins.	Proline	99-106	proline rich protein BstNI subfamily 4	Homo sapiens	16-20
8554050-6	1996	A PRB2L CON1 allele contains a single nt missense change [TCT(Ser)-->CCT (Pro)] that abolishes the potential N-linked glycosylation site (NKS-->NKP) in the Con1 protein, and this explains the Con- type.	Proline	74-77	proline rich protein BstNI subfamily 2	Homo sapiens	2-12
8874765-1	1996	We have previously shown that a proline-rich polypeptide (PRP) from ovine colostrum expresses an immunoregulatory activity in mice on humoral and cellular immune response.	Proline	32-39	proline rich protein HaeIII subfamily 1	Mus musculus	58-61
8572700-5	1996	Within the proline dehydrogenation domain, several areas of high identity were observed between B. japonicum, E. coli, S. typhimurium, Saccharomyces cerevisiae put1, and Drosophila melanogaster slgA.	Proline	11-18	proline dehydrogenase	Saccharomyces cerevisiae S288C	160-164
8572700-5	1996	Within the proline dehydrogenation domain, several areas of high identity were observed between B. japonicum, E. coli, S. typhimurium, Saccharomyces cerevisiae put1, and Drosophila melanogaster slgA.	Proline	11-18	sluggish A	Drosophila melanogaster	194-198
8645452-5	1996	The lack of islet amyloid in rodent models of diabetes is due to proline substitutions in the amyloidogenic region of IAPP.	Proline	65-72	islet amyloid polypeptide	Homo sapiens	118-122
8523543-4	1996	In contrast, altered ATRC1 receptors bearing alanine, threonine, serine, or proline at position 235 exhibited a 300- to 10,000-fold decrease in receptor capability.	Proline	76-83	solute carrier family 7 member 1	Homo sapiens	21-26
8960361-1	1996	Smooth muscle myosin light chain kinase (MLCK) features several consensus sites of phosphorylation by proline-directed protein serine/threonine kinases.	Proline	102-109	myosin light chain kinase	Gallus gallus	41-45
8960361-2	1996	The phosphorylation of MLCK by two proline-directed kinases isolated from sea star oocytes, i.e., p44mpk (Mpk, a mitogen-activated protein kinase homologue) and cyclin-dependent kinase-1 (CDK1, also known as p34cdc2), was investigated.	Proline	35-42	myosin light chain kinase	Gallus gallus	23-27
8960361-9	1996	These results indicate that MLCK activity may be regulated by phosphorylation catalyzed by proline-directed kinases, possibly directed at Thr-40 and Thr-43 at the amino terminus of MLCK.	Proline	91-98	myosin light chain kinase	Gallus gallus	28-32
8960361-9	1996	These results indicate that MLCK activity may be regulated by phosphorylation catalyzed by proline-directed kinases, possibly directed at Thr-40 and Thr-43 at the amino terminus of MLCK.	Proline	91-98	myosin light chain kinase	Gallus gallus	181-185
8868112-0	1996	Synthesis and biological evaluation of proline derivatives as potential angiotensin converting enzyme inhibitor.	Proline	39-46	angiotensin I converting enzyme	Homo sapiens	72-101
8952065-7	1996	A proline-rich region of SpOtx resembling an SH3-binding domain was used to screen an embryo cDNA expression library, and a cDNA clone was isolated and shown to be alpha-actinin.	Proline	2-9	homeobox protein OTX	Strongylocentrotus purpuratus	25-30
8952065-8	1996	A yeast two-hybrid analysis showed a specific interaction between the proline-rich region of SpOtx and a putative SH3 domain of the sea urchin alpha-actinin.	Proline	70-77	homeobox protein OTX	Strongylocentrotus purpuratus	93-98
9043863-5	1996	In this paper, we report a mutation in XNP, segregating in a family presenting an "ATR-X" phenotype without alpha-thalassemia, that causes a proline to serine transition in the helicase II domain.	Proline	141-148	ATRX chromatin remodeler	Homo sapiens	39-42
9043863-5	1996	In this paper, we report a mutation in XNP, segregating in a family presenting an "ATR-X" phenotype without alpha-thalassemia, that causes a proline to serine transition in the helicase II domain.	Proline	141-148	ATR serine/threonine kinase	Homo sapiens	83-86
8551220-0	1996	The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2.	Proline	34-41	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	18-24
8551220-0	1996	The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2.	Proline	34-41	CD2 molecule	Homo sapiens	86-89
8551220-6	1996	Each region contains a proline-rich sequence that, in the form of a synthetic peptide, directly binds p56lck.	Proline	23-30	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	102-108
8551220-7	1996	Thus, proline-rich sequences in the cytoplasmic domain of CD2 allow this transmembrane receptor to bind to the SH3 domain of p56lck.	Proline	6-13	CD2 molecule	Homo sapiens	58-61
8551220-7	1996	Thus, proline-rich sequences in the cytoplasmic domain of CD2 allow this transmembrane receptor to bind to the SH3 domain of p56lck.	Proline	6-13	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	125-131
8818201-6	1996	IGF-I and IGF-II (but to a lesser extent) stimulation was due to an increased DNA synthesis (3H-thymidine uptake) as well as protein anabolism (incorporated proline).	Proline	157-164	insulin-like growth factor 1	Rattus norvegicus	0-5
8818201-6	1996	IGF-I and IGF-II (but to a lesser extent) stimulation was due to an increased DNA synthesis (3H-thymidine uptake) as well as protein anabolism (incorporated proline).	Proline	157-164	insulin-like growth factor 2	Rattus norvegicus	10-16
8821525-1	1996	[Lys(B28),Pro(B29)]-human insulin (insulin lispro, CAS 133107-64-9, LY275585, Humalog) is a quick acting insulin analog which is currently undergoing clinical evaluation for the treatment of diabetes.	Proline	10-13	insulin	Homo sapiens	26-33
8547652-3	1996	Sequencing of the whole coding region of the c-kit showed that the point mutation found in HMC-1, P-815, and RBL-2H3 cells was absent in FMA3 cells and that the c-kit cDNA of FMA3 cells carried an in-frame deletion of 21 base pairs (bp) encoding Thr-Gln-Leu-Pro-Tyr-Asp-His at codons 573 to 579 at the juxtamembrane domain.	Proline	258-261	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	45-50
8547652-3	1996	Sequencing of the whole coding region of the c-kit showed that the point mutation found in HMC-1, P-815, and RBL-2H3 cells was absent in FMA3 cells and that the c-kit cDNA of FMA3 cells carried an in-frame deletion of 21 base pairs (bp) encoding Thr-Gln-Leu-Pro-Tyr-Asp-His at codons 573 to 579 at the juxtamembrane domain.	Proline	258-261	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	161-166
8803768-1	1996	Increased proline levels were found in plasma of a girl with slight psychomotor retardation, epilepsy, obesity, scoliosis, hypocalcaemia, variable lymphocytopenia and facial dysmorphy suggestive of CATCH 22 syndrome.	Proline	10-17	DiGeorge syndrome chromosome region	Homo sapiens	198-206
12226180-1	1996	The effect of the proline analog azetidine-2-carboxylic acid (Aze) on the induction and the regulation of heat-shock (HS) mRNA accumulation and heat-shock protein (HSP) synthesis in soybean (Glycine max) seedlings was studied.	Proline	18-25	heat shock protein	Glycine max	144-162
8524317-7	1996	A proline-to-leucine mutation in the carboxy SH3 of Vav that blocks interaction with proline-rich sequences does not modify the binding of Ku-70, which lacks this motif.	Proline	2-9	vav guanine nucleotide exchange factor 1	Homo sapiens	52-55
8524317-7	1996	A proline-to-leucine mutation in the carboxy SH3 of Vav that blocks interaction with proline-rich sequences does not modify the binding of Ku-70, which lacks this motif.	Proline	85-92	vav guanine nucleotide exchange factor 1	Homo sapiens	52-55
8944419-2	1996	Substitution of proline by m-Abz-residue may result in the development of novel substrates and inhibitors for thrombin.	Proline	16-23	coagulation factor II, thrombin	Homo sapiens	110-118
9076744-5	1996	The major structural difference noted between the human and rat mGluR1 is a deletion of 21 nucleotides which would result in the loss of seven amino acids in the middle of a proline- and glutamine-rich region of the C-terminal tail of mGluR1 alpha.	Proline	174-181	glutamate metabotropic receptor 1	Rattus norvegicus	64-70
8537404-2	1995	Sequence analysis indicates that rat TESK1 contains 628 amino acid residues, composed of an N-terminal protein kinase consensus sequence followed by a C-terminal proline-rich region.	Proline	162-169	testis associated actin remodelling kinase 1	Rattus norvegicus	37-42
8771210-2	1996	This is the first Fab structure available with a kappa light chain in which the CDR-L3 lacks the key proline residue in either position 94 or 95.	Proline	101-108	FA complementation group B	Homo sapiens	18-21
9020526-4	1996	Prolidase plays an important role in the recycling of proline for collagen synthesis and cell growth and probably serves as an interface between protein nutrition and matrix breakdown.	Proline	54-61	peptidase D	Homo sapiens	0-9
8836008-7	1996	In view of these findings with the alpha-hydroxyacyl-prolyl-arginals, it is very likely that the less favorable biologic properties of Boc-D-Phe-Pro-Arg-H are due to the hydrophobicity and bulkiness of the terminal Boc-NH rather than its neutrality.	Proline	145-148	BOC cell adhesion associated, oncogene regulated	Homo sapiens	135-138
12237689-3	1996	The Mutation of lle 123 to Pro in helix 3 or the insertion of 4 amino acids (PDPD) between 112 and 113 in alpha-helix 2 led to the complete loss of DNA-binding activity of PHO2, while the mutation of Pro 117 to Ala in beta-turn did not affect the binding activity significantly.	Proline	27-30	Pho2p	Saccharomyces cerevisiae S288C	172-176
8537363-4	1995	However, proline substitution abolished rhodopsin interaction, suggesting that flexibility is important at this site.	Proline	9-16	rhodopsin	Homo sapiens	40-49
8825895-3	1995	A point mutation in the ADSL gene, resulting in a predicted serine-to-proline substitution and conferring structural instability to the mutant enzyme, has been reported previously in 3 affected siblings.	Proline	70-77	adenylosuccinate lyase	Homo sapiens	24-28
8618911-0	1995	Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands.	Proline	34-41	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	70-73
8543151-0	1995	A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3.	Proline	2-9	transforming growth factor beta 1	Homo sapiens	15-23
8849336-2	1995	We previously used the peptidyl-prolyl cis-trans isomerase, cyclophilin, to show that angiotensin converting enzyme (ACE) preferentially hydrolyzes the trans isomer of a synthetic tripeptide that contains a C-terminal proline (Dawson et al., Am J Physiol 257:H853-H865, 1989; Merker et al., J Appl Physiol 75: 1519-1524, 1993).	Proline	218-225	angiotensin I converting enzyme	Rattus norvegicus	86-115
8849336-2	1995	We previously used the peptidyl-prolyl cis-trans isomerase, cyclophilin, to show that angiotensin converting enzyme (ACE) preferentially hydrolyzes the trans isomer of a synthetic tripeptide that contains a C-terminal proline (Dawson et al., Am J Physiol 257:H853-H865, 1989; Merker et al., J Appl Physiol 75: 1519-1524, 1993).	Proline	218-225	angiotensin I converting enzyme	Rattus norvegicus	117-120
8543151-2	1995	We show that TGF-beta specifically induces the activity of the proline-rich trans-activation domain of CTF-1, a member of the CTF/NF-I family of transcription factors.	Proline	63-70	transforming growth factor beta 1	Homo sapiens	13-21
8543151-2	1995	We show that TGF-beta specifically induces the activity of the proline-rich trans-activation domain of CTF-1, a member of the CTF/NF-I family of transcription factors.	Proline	63-70	cardiotrophin 1	Homo sapiens	103-108
8543151-3	1995	A TGF-beta-responsive domain (TRD) in the proline-rich transcriptional activation sequence of CTF-1 was shown to mediate TGF-beta induction in NIH-3T3 cells.	Proline	42-49	transforming growth factor beta 1	Homo sapiens	2-10
8543151-3	1995	A TGF-beta-responsive domain (TRD) in the proline-rich transcriptional activation sequence of CTF-1 was shown to mediate TGF-beta induction in NIH-3T3 cells.	Proline	42-49	cardiotrophin 1	Mus musculus	94-99
8543151-3	1995	A TGF-beta-responsive domain (TRD) in the proline-rich transcriptional activation sequence of CTF-1 was shown to mediate TGF-beta induction in NIH-3T3 cells.	Proline	42-49	transforming growth factor, beta 1	Mus musculus	121-129
8526861-4	1995	We found that the proline-rich C-terminal domains of both rat and human alpha-ENaC, expressed as glutathione S-transferase fusion proteins, bound to SH3 domains in vitro.	Proline	18-25	sodium channel epithelial 1 subunit alpha	Homo sapiens	72-82
8532536-7	1995	The TIEG protein contains three zinc finger motifs, several proline-rich src homology-3 (SH3) binding domains at the C-terminal end, and is homologous in this region to the zinc finger-containing transcription factor family of genes.	Proline	60-67	Kruppel like factor 10	Homo sapiens	4-8
8526861-8	1995	These data suggest that the proline-rich C-terminal tail of alpha-ENaC may interact with other proteins that control its function, regulation or localization.	Proline	28-35	sodium channel epithelial 1 subunit alpha	Homo sapiens	60-70
8719885-5	1995	Adding the RGD peptide, Gly-Arg-Gly-Glu-Ser-Pro to the medium of sparsely plated cells resulted in rapid reductions in cell spreading concomitant with dose-dependent decreases in ornithine decarboxylase activity and putrescine uptake.	Proline	44-47	ornithine decarboxylase 1	Rattus norvegicus	179-202
8749393-5	1995	The PI3K_68D cDNA encodes a protein of 210 kDa, which lacks sequences implicated in linking p110 PI 3-kinases to p85 adaptor proteins, but contains an amino-terminal proline-rich sequence, which could bind to SH3 domains, and a carboxy-terminal C2 domain.	Proline	166-173	Phosphatidylinositol 3-kinase 68D	Drosophila melanogaster	4-12
7595540-2	1995	Five copies of the TRH progenitor sequence (Gln-His-Pro-Gly) and seven cryptic peptides are formed following posttranslational proteolytic cleavage of the 26-kDa rat proTRH precursor.	Proline	52-55	thyrotropin releasing hormone	Rattus norvegicus	19-22
8847499-4	1995	The results show that the lack of prolines in the P-loop, which is unique to HPV-16 E1, significantly weakens its ATP-binding and ATPase activities without affecting its ability to complex with the HPV-16 E2 protein.	Proline	34-42	replication protein E1	Human papillomavirus type 16	84-86
8847499-0	1995	The ATP-binding and ATPase activities of human papillomavirus type 16 E1 are significantly weakened by the absence of prolines in its ATP-binding domain.	Proline	118-126	replication protein E1	Human papillomavirus type 16	70-72
7595554-4	1995	KKIALRE-immunoreactive proteins were capable of phosphorylating histone and synthetic peptides with the X-Ser-Pro-X motif, indicating that these proteins belong to the proline-directed Ser/Thr protein kinase family.	Proline	168-175	cyclin dependent kinase like 1	Homo sapiens	0-7
8524219-3	1995	Strikingly, serine-to-proline substitutions at analogous positions in Ste7p (position 368) and Mkk1p (position 386) were recovered by independent genetic screens.	Proline	22-29	mitogen-activated protein kinase kinase STE7	Saccharomyces cerevisiae S288C	70-75
8524219-3	1995	Strikingly, serine-to-proline substitutions at analogous positions in Ste7p (position 368) and Mkk1p (position 386) were recovered by independent genetic screens.	Proline	22-29	mitogen-activated protein kinase kinase MKK1	Saccharomyces cerevisiae S288C	95-100
7493031-6	1995	We identified a missense mutation in one allele of keratin 13 that leads to proline substitution for a conserved leucine.	Proline	76-83	keratin 13	Homo sapiens	51-61
7499236-6	1995	A carboxyl-terminal proline/alanine-rich region of EVX1 seems to be responsible for the transcriptional repression activity, as suggested by transfection of EVX1 mutants.	Proline	20-27	even-skipped homeobox 1	Homo sapiens	51-55
7499191-1	1995	In human platelets a proline-directed kinase distinct from the ERK MAP kinases is stimulated by both thrombin and the thrombin receptor agonist peptide SFLLRN and may be involved in the activation of Ca(2+)-dependent cytosolic phospholipase A2 (Kramer, R. M., Roberts, E. F., Hyslop, P. A., Utterback, B. G., Hui, K. Y., and Jakubowski, J.A.	Proline	21-28	coagulation factor II, thrombin	Homo sapiens	101-109
7499191-1	1995	In human platelets a proline-directed kinase distinct from the ERK MAP kinases is stimulated by both thrombin and the thrombin receptor agonist peptide SFLLRN and may be involved in the activation of Ca(2+)-dependent cytosolic phospholipase A2 (Kramer, R. M., Roberts, E. F., Hyslop, P. A., Utterback, B. G., Hui, K. Y., and Jakubowski, J.A.	Proline	21-28	coagulation factor II, thrombin	Homo sapiens	118-126
8614406-0	1995	The proline-rich region of the GH receptor is essential for JAK2 phosphorylation, activation of cell proliferation, and gene transcription.	Proline	4-11	growth hormone receptor	Cricetulus griseus	31-42
8614406-0	1995	The proline-rich region of the GH receptor is essential for JAK2 phosphorylation, activation of cell proliferation, and gene transcription.	Proline	4-11	tyrosine-protein kinase JAK2	Cricetulus griseus	60-64
8614406-1	1995	Mutational analysis of the proximal transmembrane region of the cytoplasmic domain of the GH receptor (GHR) allowed us to characterize box 1, a proline-rich sequence of eight amino acids, which has been shown to be critical for signal transduction of many cytokine receptors.	Proline	144-151	growth hormone receptor	Cricetulus griseus	90-101
8614406-1	1995	Mutational analysis of the proximal transmembrane region of the cytoplasmic domain of the GH receptor (GHR) allowed us to characterize box 1, a proline-rich sequence of eight amino acids, which has been shown to be critical for signal transduction of many cytokine receptors.	Proline	144-151	growth hormone receptor	Cricetulus griseus	103-106
8772226-7	1995	Analysis of these polymorphisms in 20 volunteers showed that only the Pro/Ser polymorphism at position 186 in exon 5 was coupled to the form of the HRG protein.	Proline	70-73	histidine rich glycoprotein	Homo sapiens	148-151
8522173-3	1995	Here, it is reported that the human p105 C-terminal region is phosphorylated in vivo on Ser894 and Ser908, which are potential phosphorylation sites in vitro for proline-directed serine/threonine kinases such as cyclin-dependent kinase.	Proline	162-169	nuclear factor kappa B subunit 1	Homo sapiens	36-40
7499191-1	1995	In human platelets a proline-directed kinase distinct from the ERK MAP kinases is stimulated by both thrombin and the thrombin receptor agonist peptide SFLLRN and may be involved in the activation of Ca(2+)-dependent cytosolic phospholipase A2 (Kramer, R. M., Roberts, E. F., Hyslop, P. A., Utterback, B. G., Hui, K. Y., and Jakubowski, J.A.	Proline	21-28	phospholipase A2 group IVA	Homo sapiens	217-243
7499236-6	1995	A carboxyl-terminal proline/alanine-rich region of EVX1 seems to be responsible for the transcriptional repression activity, as suggested by transfection of EVX1 mutants.	Proline	20-27	even-skipped homeobox 1	Homo sapiens	157-161
7499242-6	1995	In addition, like pp125FAK, RAFTK contains a kinase domain flanked by large N-terminal (426 residues) and C-terminal (331 residues) domains, and the C-terminal region contains a predicted proline-rich stretch of residues.	Proline	188-195	protein tyrosine kinase 2	Homo sapiens	18-26
7499242-6	1995	In addition, like pp125FAK, RAFTK contains a kinase domain flanked by large N-terminal (426 residues) and C-terminal (331 residues) domains, and the C-terminal region contains a predicted proline-rich stretch of residues.	Proline	188-195	protein tyrosine kinase 2 beta	Homo sapiens	28-33
7488142-3	1995	Peptides containing a proline residue in the sequence Pro-X-Thr-Pro-X-basic amino acid (motif B) had higher affinity for both Cdk2 complexes than peptides containing motif A.	Proline	22-29	cyclin dependent kinase 2	Homo sapiens	126-130
7579348-4	1995	A point mutation was found in codon 129 of the GPIb alpha gene that results in the substitution of proline for leucine in the first position of the fifth leucine-rich glycoprotein repeat of the mature gene product.	Proline	99-106	glycoprotein Ib platelet subunit alpha	Homo sapiens	47-57
7594475-6	1995	In marked contrast to the previously published human CD6 sequence, the mouse sequence predicts a long cytoplasmic tail that is not closely related to other proteins and possesses two proline-rich motifs containing the SH3-domain binding consensus sequence, three protein kinase C phosphorylation site motifs, nine casein kinase-2 phosphorylation site motifs, and a serine-threonine-rich motif repeated three times.	Proline	183-190	CD6 molecule	Homo sapiens	53-56
7488142-4	1995	Furthermore, differences in substrate affinity between the two Cdk2 complexes were caused by a proline residue adjacent to or three positions before the threonine residue.	Proline	95-102	cyclin dependent kinase 2	Homo sapiens	63-67
8789253-4	1995	In contrast, the induction of PH alpha and HSP47 expression was markedly attenuated in high PDL cells, indicating an age-related decrease in response to procollagen retention in the ER caused by hypohydroxylation of proline residues of procollagens.	Proline	216-223	lamin B receptor	Homo sapiens	30-38
7592992-8	1995	This dystrophin binding site is located in a proline-rich environment of beta-dystroglycan within amino acids 880-895.	Proline	45-52	dystrophin	Homo sapiens	5-15
7479864-4	1995	These SH3 domains bind to the same proline-rich region of FAK (APPKPSR) encompassing residues 711-717.	Proline	35-42	PTK2 protein tyrosine kinase 2	Mus musculus	58-61
7590236-4	1995	Abi-2 is a novel protein that contains an SH3 domain and proline-rich sequences critical for binding to c-Abl.	Proline	57-64	abl interactor 2	Homo sapiens	0-5
9383482-3	1995	A polypeptide representing the relevant sequence from the alpha-subunit of the nAChR (Ac-Tyr-Cys-Glu-Ile-Ile-Val-Thr-His-Phe-Pro-Phe-Asp-Gln-Gln Asn-Cys-Thr-NH2) is small enough to allow detailed structural analysis, which may provide insight into the role of glycosylation in the maturation process that leads to ion-channel assembly.	Proline	125-128	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	79-84
7590236-4	1995	Abi-2 is a novel protein that contains an SH3 domain and proline-rich sequences critical for binding to c-Abl.	Proline	57-64	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	104-109
7473586-10	1995	This suggests that the selectivity of NPY receptors is highly dependent on subtle conformational changes such as the substitution of residue 34 to a proline or the introduction of intramolecular constraints.	Proline	149-156	neuropeptide Y	Homo sapiens	38-41
7495695-3	1995	Proline is on the carboxy terminus of serine 118, which suggests that the serine-proline may be a consensus phosphorylation site motif for either the mitogen-activated protein (MAP) kinase or p34cdc2 kinase.	Proline	0-7	cyclin dependent kinase 1	Homo sapiens	192-199
7495695-3	1995	Proline is on the carboxy terminus of serine 118, which suggests that the serine-proline may be a consensus phosphorylation site motif for either the mitogen-activated protein (MAP) kinase or p34cdc2 kinase.	Proline	81-88	cyclin dependent kinase 1	Homo sapiens	192-199
7565748-6	1995	Beyond this domain, the sequences diverge significantly, although the putative transactivation domains for both LKLF and EKLF are proline-rich regions.	Proline	130-137	Kruppel like factor 2	Homo sapiens	112-116
7565748-6	1995	Beyond this domain, the sequences diverge significantly, although the putative transactivation domains for both LKLF and EKLF are proline-rich regions.	Proline	130-137	Kruppel like factor 1	Homo sapiens	121-125
7579448-2	1995	Another frequent polymorphism was described in exon XV of the PROS1 gene, in the codon for Pro 626 (CCA/CCG).	Proline	91-94	protein S	Homo sapiens	62-67
7474093-1	1995	The human immunodeficiency virus type 1 (HIV-1) Gag protein precursor, Pr55Gag, contains at its C-terminal end a proline-rich, 6-kDa domain designated p6.	Proline	113-120	Pr55(Gag)	Human immunodeficiency virus 1	71-78
7488069-3	1995	A corresponding proline at this position is also found in the rat thrombin receptor.	Proline	16-23	coagulation factor II (thrombin) receptor	Rattus norvegicus	66-83
7592693-9	1995	Both Grb2 and EGF receptors are released from Cbl in the presence of a proline-rich peptide that binds the NH2-terminal SH3 domain of Grb2.	Proline	71-78	growth factor receptor bound protein 2	Homo sapiens	5-9
7592693-9	1995	Both Grb2 and EGF receptors are released from Cbl in the presence of a proline-rich peptide that binds the NH2-terminal SH3 domain of Grb2.	Proline	71-78	epidermal growth factor	Homo sapiens	14-17
7592693-9	1995	Both Grb2 and EGF receptors are released from Cbl in the presence of a proline-rich peptide that binds the NH2-terminal SH3 domain of Grb2.	Proline	71-78	Cbl proto-oncogene	Homo sapiens	46-49
7592693-9	1995	Both Grb2 and EGF receptors are released from Cbl in the presence of a proline-rich peptide that binds the NH2-terminal SH3 domain of Grb2.	Proline	71-78	growth factor receptor bound protein 2	Homo sapiens	134-138
7592693-10	1995	These results indicate that autophosphorylated EGF receptors associate with the SH2 domain of Grb2, which is complexed through its SH3 domain with proline-rich regions of Cbl.	Proline	147-154	epidermal growth factor	Homo sapiens	47-50
7592693-10	1995	These results indicate that autophosphorylated EGF receptors associate with the SH2 domain of Grb2, which is complexed through its SH3 domain with proline-rich regions of Cbl.	Proline	147-154	growth factor receptor bound protein 2	Homo sapiens	94-98
7592693-10	1995	These results indicate that autophosphorylated EGF receptors associate with the SH2 domain of Grb2, which is complexed through its SH3 domain with proline-rich regions of Cbl.	Proline	147-154	Cbl proto-oncogene	Homo sapiens	171-174
7578250-5	1995	However, B4-2 has an unusually high proline content (13%), contains a putative nuclear targeting sequence, and has several SPXX motifs which are frequently found in gene regulatory proteins.	Proline	36-43	proline rich nuclear receptor coactivator 1	Homo sapiens	9-13
7478580-7	1995	Our results also show that the oncogenic 70Z/3 form of cbl has enhanced binding to the EGF receptor and that peptides spanning the proline-rich region bind a range SH3 domains.	Proline	131-138	Casitas B-lineage lymphoma	Mus musculus	55-58
7478592-0	1995	The proline-rich region of Vav binds to Grb2 and Grb3-3.	Proline	4-11	vav 1 oncogene	Mus musculus	27-30
7478592-0	1995	The proline-rich region of Vav binds to Grb2 and Grb3-3.	Proline	4-11	growth factor receptor bound protein 2	Mus musculus	40-44
7478592-7	1995	By the use of an in vivo genetic approach (the double hybrid system) and through in vitro experiments (glutathione-S-transferase fusion proteins) we furnish evidence that the interaction between Vav and Grb2 involves the C-SH3 domain of Grb2 and the proline-rich region located in the N-SH3 of Vav.	Proline	250-257	vav 1 oncogene	Mus musculus	195-198
7478592-7	1995	By the use of an in vivo genetic approach (the double hybrid system) and through in vitro experiments (glutathione-S-transferase fusion proteins) we furnish evidence that the interaction between Vav and Grb2 involves the C-SH3 domain of Grb2 and the proline-rich region located in the N-SH3 of Vav.	Proline	250-257	growth factor receptor bound protein 2	Mus musculus	203-207
7478592-7	1995	By the use of an in vivo genetic approach (the double hybrid system) and through in vitro experiments (glutathione-S-transferase fusion proteins) we furnish evidence that the interaction between Vav and Grb2 involves the C-SH3 domain of Grb2 and the proline-rich region located in the N-SH3 of Vav.	Proline	250-257	growth factor receptor bound protein 2	Mus musculus	237-241
7577928-3	1995	In contrast, Pro1TRH, which has a protonated proline in place of the pGlu of TRH, was 10 times more potent for the N289D receptor than for the wild-type.	Proline	45-52	thyrotropin releasing hormone	Rattus norvegicus	17-20
7487060-1	1995	Dipeptidyl-peptidase IV (EC 3.4.14.5) also known as CD26 is a membrane-bound serine peptidase which cleaves N-terminal dipeptides from a peptide chain containing a proline residue in the penultimate position.	Proline	164-171	dipeptidylpeptidase 4	Rattus norvegicus	0-23
7487060-1	1995	Dipeptidyl-peptidase IV (EC 3.4.14.5) also known as CD26 is a membrane-bound serine peptidase which cleaves N-terminal dipeptides from a peptide chain containing a proline residue in the penultimate position.	Proline	164-171	dipeptidylpeptidase 4	Rattus norvegicus	52-56
7487060-3	1995	A series of aminoacylpyrrolidine-2-nitriles, in which the carboxyl group of proline is replaced by a nitrile group, was synthesized as inhibitors of dipeptidyl-peptidase IV.	Proline	76-83	dipeptidylpeptidase 4	Rattus norvegicus	149-172
7589480-3	1995	Here, we report that the Src homology 3 (SH3) domain of Fyn binds to the proline-rich cytoplasmic region of FasL.	Proline	73-80	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	25-28
7589480-3	1995	Here, we report that the Src homology 3 (SH3) domain of Fyn binds to the proline-rich cytoplasmic region of FasL.	Proline	73-80	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	56-59
7589480-3	1995	Here, we report that the Src homology 3 (SH3) domain of Fyn binds to the proline-rich cytoplasmic region of FasL.	Proline	73-80	Fas ligand	Homo sapiens	108-112
7479029-0	1995	TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription.	Proline	63-70	transcription factor binding to IGHM enhancer 3	Homo sapiens	0-4
7588819-0	1995	Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties.	Proline	39-46	Metchnikowin	Drosophila melanogaster	0-12
7588819-6	1995	The novel peptide, which we propose to name metchnikowin, is a member of a family of proline-rich peptides, and we discuss the possible evolutionary relationships within this family.	Proline	85-92	Metchnikowin	Drosophila melanogaster	44-56
7590229-3	1995	In addition, capu shares both a proline-rich region and a 70-amino-acid domain with a number of other genes, two of which also function in pattern formation, the Saccharomyes cerevisiae BNI1 gene and the Aspergillus FigA gene.	Proline	32-39	cappuccino	Drosophila melanogaster	13-17
7478566-1	1995	The mouse protein mSos1 has a central Ras guanine nucleotide exchange domain, and a long proline-rich C-terminal tail which contains several potential binding sites for the SH3 domains of the adaptor protein, Grb2.	Proline	89-96	SOS Ras/Rac guanine nucleotide exchange factor 1	Mus musculus	18-23
7563081-2	1995	Analogs of FpA and FpA Rouen have been designed that include a Pro15 to replace Val15 in natural FpA and to mimic the frequent occurrences of a proline residue at equivalent positions of other protein substrates of thrombin.	Proline	144-151	coagulation factor II, thrombin	Homo sapiens	215-223
7548057-6	1995	The best inhibitors of thrombin contained Pro or Gly at the P2 position in place of Phe353, with 2- and 7-fold increases in activity, respectively.	Proline	42-45	coagulation factor II, thrombin	Homo sapiens	23-31
7478566-1	1995	The mouse protein mSos1 has a central Ras guanine nucleotide exchange domain, and a long proline-rich C-terminal tail which contains several potential binding sites for the SH3 domains of the adaptor protein, Grb2.	Proline	89-96	growth factor receptor bound protein 2	Mus musculus	209-213
7478566-6	1995	These common phosphorylation sites have been mapped to a region encompassing the first three proline (pro)-rich motifs in the tail of mSos1.	Proline	93-100	SOS Ras/Rac guanine nucleotide exchange factor 1	Mus musculus	134-139
7478566-6	1995	These common phosphorylation sites have been mapped to a region encompassing the first three proline (pro)-rich motifs in the tail of mSos1.	Proline	93-96	SOS Ras/Rac guanine nucleotide exchange factor 1	Mus musculus	134-139
7556942-4	1995	In addition, the 5" end of msh has 52% sequence identity to the 5" end of the empty spiracles gene and encodes several stretches of amino acids rich in serine, alanine, proline, glutamine, and acidic amino acids, indicating potential domains of regulatory activity.	Proline	169-176	Drop	Drosophila melanogaster	27-30
7590268-0	1995	The Drosophila melanogaster homolog of the mammalian MAPK-activated protein kinase-2 (MAPKAPK-2) lacks a proline-rich N-terminus.	Proline	105-112	MAPK activated protein kinase 2	Homo sapiens	53-84
7590268-0	1995	The Drosophila melanogaster homolog of the mammalian MAPK-activated protein kinase-2 (MAPKAPK-2) lacks a proline-rich N-terminus.	Proline	105-112	MAPK activated protein kinase 2	Homo sapiens	86-95
7586939-0	1995	[Lys(B28), Pro(B29)]-human insulin: effect of injection time on postprandial glycemia.	Proline	11-14	insulin	Homo sapiens	27-34
7586939-1	1995	BACKGROUND: [Lys(B28), Pro(B29)]-human insulin (lispro) is an insulin analogue with a reduced capacity for self-association and faster absorption from subcutaneous injection sites.	Proline	23-26	insulin	Homo sapiens	39-46
7586939-1	1995	BACKGROUND: [Lys(B28), Pro(B29)]-human insulin (lispro) is an insulin analogue with a reduced capacity for self-association and faster absorption from subcutaneous injection sites.	Proline	23-26	insulin	Homo sapiens	62-69
8595418-5	1995	DSCR1 encodes a novel protein which has an acidic domain, a serine-proline motif, a putative DNA binding domain and a proline-rich region with the characteristics of a SH3 domain ligand.	Proline	67-74	regulator of calcineurin 1	Homo sapiens	0-5
7664666-2	1995	Rat pro-TRH contains five copies of the TRH progenitor sequence (Gln-His-Pro-Gly) and seven other cryptic peptides.	Proline	73-76	thyrotropin releasing hormone	Rattus norvegicus	4-11
8595418-5	1995	DSCR1 encodes a novel protein which has an acidic domain, a serine-proline motif, a putative DNA binding domain and a proline-rich region with the characteristics of a SH3 domain ligand.	Proline	118-125	regulator of calcineurin 1	Homo sapiens	0-5
7561881-3	1995	A unique proline-rich region distinguished hVH-5 from other closely related protein tyrosine phosphatases.	Proline	9-16	dual specificity phosphatase 8	Homo sapiens	43-48
8576104-10	1995	MEP cleaved oligopeptides even on the carboxyl side of proline residue and these peptides are resistant to hydrolysis by the cytosol-derived proteasome, therefore MEP may participate in the catabolism of oligopeptides in the cytosol, together with other endo-oligopeptidases.	Proline	55-62	neurolysin	Bos taurus	0-3
8576104-10	1995	MEP cleaved oligopeptides even on the carboxyl side of proline residue and these peptides are resistant to hydrolysis by the cytosol-derived proteasome, therefore MEP may participate in the catabolism of oligopeptides in the cytosol, together with other endo-oligopeptidases.	Proline	55-62	neurolysin	Bos taurus	163-166
8562067-7	1995	Amino acid analysis, Edman degradation, and FAB-MS identified T11 as the N-blocked decapeptide pyro-Gln-Pro-Val-Trp-Gln-Asp-Glu-Gly-Gln-Arg derived from the N-terminus of pZPC.	Proline	104-107	FA complementation group B	Homo sapiens	44-47
7565714-2	1995	Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two hydrophobic interactions (between aliphatic proline dipeptides in the SH3 ligand and highly conserved aromatic residues on the surface of the SH3 domain), and one salt bridge (between Asp-99 of Src and an Arg three residues upstream of the conserved Pro-X-X-Pro motif in the ligand).	Proline	67-74	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	27-30
7565714-2	1995	Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two hydrophobic interactions (between aliphatic proline dipeptides in the SH3 ligand and highly conserved aromatic residues on the surface of the SH3 domain), and one salt bridge (between Asp-99 of Src and an Arg three residues upstream of the conserved Pro-X-X-Pro motif in the ligand).	Proline	67-74	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-46
7565714-2	1995	Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two hydrophobic interactions (between aliphatic proline dipeptides in the SH3 ligand and highly conserved aromatic residues on the surface of the SH3 domain), and one salt bridge (between Asp-99 of Src and an Arg three residues upstream of the conserved Pro-X-X-Pro motif in the ligand).	Proline	67-74	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-46
7565714-2	1995	Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two hydrophobic interactions (between aliphatic proline dipeptides in the SH3 ligand and highly conserved aromatic residues on the surface of the SH3 domain), and one salt bridge (between Asp-99 of Src and an Arg three residues upstream of the conserved Pro-X-X-Pro motif in the ligand).	Proline	203-210	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	27-30
7565714-2	1995	Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two hydrophobic interactions (between aliphatic proline dipeptides in the SH3 ligand and highly conserved aromatic residues on the surface of the SH3 domain), and one salt bridge (between Asp-99 of Src and an Arg three residues upstream of the conserved Pro-X-X-Pro motif in the ligand).	Proline	203-210	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-46
7565714-2	1995	Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two hydrophobic interactions (between aliphatic proline dipeptides in the SH3 ligand and highly conserved aromatic residues on the surface of the SH3 domain), and one salt bridge (between Asp-99 of Src and an Arg three residues upstream of the conserved Pro-X-X-Pro motif in the ligand).	Proline	203-210	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-46
7565670-0	1995	A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function.	Proline	2-9	mitogen-activated protein kinase kinase 1	Homo sapiens	34-38
7565670-0	1995	A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function.	Proline	2-9	mitogen-activated protein kinase kinase 2	Homo sapiens	43-47
7565670-0	1995	A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function.	Proline	2-9	zinc fingers and homeoboxes 2	Homo sapiens	64-67
7565670-0	1995	A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function.	Proline	2-9	mitogen-activated protein kinase kinase 7	Homo sapiens	34-37
7565670-1	1995	Mammalian MEK1 and MEK2 contain a proline-rich (PR) sequence that is absent both from the yeast homologs Ste7 and Byr1 and from a recently cloned activator of the JNK/stress-activated protein kinases, SEK1/MKK4.	Proline	34-41	serine/threonine protein kinase MEK1	Saccharomyces cerevisiae S288C	10-14
7565670-1	1995	Mammalian MEK1 and MEK2 contain a proline-rich (PR) sequence that is absent both from the yeast homologs Ste7 and Byr1 and from a recently cloned activator of the JNK/stress-activated protein kinases, SEK1/MKK4.	Proline	34-41	mitogen-activated protein kinase kinase 2	Homo sapiens	19-23
8562067-7	1995	Amino acid analysis, Edman degradation, and FAB-MS identified T11 as the N-blocked decapeptide pyro-Gln-Pro-Val-Trp-Gln-Asp-Glu-Gly-Gln-Arg derived from the N-terminus of pZPC.	Proline	104-107	CD2 molecule	Homo sapiens	62-65
7673234-6	1995	An additional increase in agonist activity was observed when the beta-bulge was co-expressed with a second substitution (His-54 --&gt; Pro) in IL-1ra K145D.	Proline	135-138	interleukin 1 receptor antagonist	Homo sapiens	143-149
7556671-2	1995	Deduced from its nucleotide sequence, PDIR has the three CXXC-like motifs (Cys-Ser-Met-Cys, Cys-Gly-His-Cys and Cys-Pro-His-Cys), which are found in proteins within the PDI superfamily and are responsible for oxidoreductase activity.	Proline	116-119	protein disulfide isomerase family A member 5	Homo sapiens	38-42
7566970-7	1995	Inhibition studies with BIAcore using proline rich peptides derived from the C-terminus of Sos1 show that there is a single major binding site for Grb2 in Sos1.	Proline	38-45	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	91-95
7566970-7	1995	Inhibition studies with BIAcore using proline rich peptides derived from the C-terminus of Sos1 show that there is a single major binding site for Grb2 in Sos1.	Proline	38-45	growth factor receptor bound protein 2	Homo sapiens	147-151
7566970-7	1995	Inhibition studies with BIAcore using proline rich peptides derived from the C-terminus of Sos1 show that there is a single major binding site for Grb2 in Sos1.	Proline	38-45	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	155-159
7665623-1	1995	In a previous analysis, we identified a point mutation that substituted Pro (CCG) for Leu (CTG) at amino acid 87 in the alpha-subunit of the insulin receptor (IR) in a Japanese patient with leprechaunism.	Proline	72-75	insulin receptor	Homo sapiens	141-157
7665623-1	1995	In a previous analysis, we identified a point mutation that substituted Pro (CCG) for Leu (CTG) at amino acid 87 in the alpha-subunit of the insulin receptor (IR) in a Japanese patient with leprechaunism.	Proline	72-75	insulin receptor	Homo sapiens	159-161
7665623-6	1995	The autophosphorylation of Pro-87 IR was less sensitive to insulin than that of Leu-87 IR, suggesting the reduced insulin binding affinity.	Proline	27-30	insulin	Homo sapiens	59-66
7665623-6	1995	The autophosphorylation of Pro-87 IR was less sensitive to insulin than that of Leu-87 IR, suggesting the reduced insulin binding affinity.	Proline	27-30	insulin	Homo sapiens	114-121
7486672-0	1995	The proline-rich motif is necessary but not sufficient for prolactin receptor signal transduction.	Proline	4-11	prolactin receptor	Homo sapiens	59-77
7673134-2	1995	Two proline mimetics, the enantiomers of 2-aza-bicyclo[2,2,1]heptane-3-carboxylic acid, have been incorporated in place of Pro30 into synthetic peptides based on the B-loop beta-sheet sequence of human transforming growth factor-alpha (TGF-alpha) (residues Cys21-Cys32).	Proline	4-11	tumor necrosis factor	Homo sapiens	202-234
7673134-2	1995	Two proline mimetics, the enantiomers of 2-aza-bicyclo[2,2,1]heptane-3-carboxylic acid, have been incorporated in place of Pro30 into synthetic peptides based on the B-loop beta-sheet sequence of human transforming growth factor-alpha (TGF-alpha) (residues Cys21-Cys32).	Proline	4-11	transforming growth factor alpha	Homo sapiens	236-245
11854844-2	1995	NF-IL6 contains, at its N-terminus, an alanine- and proline-rich transactivation domain, followed at the C-terminus by a basic domain-leucine zipper (bZIP) DNA-binding motif.	Proline	52-59	CCAAT enhancer binding protein beta	Homo sapiens	0-6
7668281-6	1995	The predicted consequent incorrect splicing results in truncation of the PAX6 proline-serine-threonine activation domain.	Proline	78-85	paired box 6	Homo sapiens	73-77
7648278-7	1995	In contrast, gag constructs with double Pro-10-Pro-11 substitutions for Leu-10-Leu-11 or a premature termination codon at position Pro-49 of p6 were still able to incorporate Vpr, however, with lower efficiency than wild type.	Proline	40-43	Pr55(Gag)	Human immunodeficiency virus 1	13-16
8585605-3	1995	In order to examine molecular determinants of the proline motif:SH3 interaction, an enzyme-linked immunosorbent assay was developed to observe binding of 5-lipoxygenase to SH3 domains of growth factor receptor binding protein 2 (Grb2).	Proline	50-57	arachidonate 5-lipoxygenase	Homo sapiens	154-168
8585605-3	1995	In order to examine molecular determinants of the proline motif:SH3 interaction, an enzyme-linked immunosorbent assay was developed to observe binding of 5-lipoxygenase to SH3 domains of growth factor receptor binding protein 2 (Grb2).	Proline	50-57	growth factor receptor bound protein 2	Homo sapiens	187-227
8585605-3	1995	In order to examine molecular determinants of the proline motif:SH3 interaction, an enzyme-linked immunosorbent assay was developed to observe binding of 5-lipoxygenase to SH3 domains of growth factor receptor binding protein 2 (Grb2).	Proline	50-57	growth factor receptor bound protein 2	Homo sapiens	229-233
7588705-0	1995	Two regions with differential growth-modulating activity in the N-terminal domain of ras GTPase-activating protein (p120GAP) src homology and Gly-Ala-Pro-rich regions.	Proline	150-153	RAS p21 protein activator 1	Rattus norvegicus	116-123
7588705-0	1995	Two regions with differential growth-modulating activity in the N-terminal domain of ras GTPase-activating protein (p120GAP) src homology and Gly-Ala-Pro-rich regions.	Proline	150-153	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	125-128
7556201-1	1995	1H-NMR and circular dichroism studies have been carried out on osteocalcin, a 49-residue, calcium-binding protein, the sequence of which contains a disulphide bridge, a proline-rich segment and three gamma-carboxyglutamic acid (Gla) residues.	Proline	169-176	bone gamma-carboxyglutamate protein	Bos taurus	63-74
7592046-3	1995	Two diastereotopic methyls, C-11 and C-12 of lactacystin were found to originate from the pro-R and pro-S methyls of leucine, respectively, as shown by incorporating a new type of chiral 13C-labeled L-leucine.	Proline	90-93	RNA polymerase III subunit K	Homo sapiens	28-32
7648278-7	1995	In contrast, gag constructs with double Pro-10-Pro-11 substitutions for Leu-10-Leu-11 or a premature termination codon at position Pro-49 of p6 were still able to incorporate Vpr, however, with lower efficiency than wild type.	Proline	40-43	Vpr	Human immunodeficiency virus 1	175-178
7654718-1	1995	Glycosylation positions and oligosaccharide characteristics in the proline-rich, mucin-like, C-terminal region (C-tail) of human milk bile salt-activated lipase (BAL) were studied in order to assess the possible physiological functions of this region.	Proline	67-74	carboxyl ester lipase	Homo sapiens	134-160
7477934-2	1995	In vitro, mitogen-activated protein kinase is able to phosphorylate the microtubule-associated protein tau at Ser-Pro and Thr-Pro sites, thereby generating abnormally hyperphosphorylated tau species that are similar to paired helical filament-tau found in Alzheimer"s disease.	Proline	114-117	microtubule associated protein tau	Homo sapiens	72-106
7477934-2	1995	In vitro, mitogen-activated protein kinase is able to phosphorylate the microtubule-associated protein tau at Ser-Pro and Thr-Pro sites, thereby generating abnormally hyperphosphorylated tau species that are similar to paired helical filament-tau found in Alzheimer"s disease.	Proline	114-117	microtubule associated protein tau	Homo sapiens	103-106
7477934-2	1995	In vitro, mitogen-activated protein kinase is able to phosphorylate the microtubule-associated protein tau at Ser-Pro and Thr-Pro sites, thereby generating abnormally hyperphosphorylated tau species that are similar to paired helical filament-tau found in Alzheimer"s disease.	Proline	126-129	microtubule associated protein tau	Homo sapiens	72-106
7477934-2	1995	In vitro, mitogen-activated protein kinase is able to phosphorylate the microtubule-associated protein tau at Ser-Pro and Thr-Pro sites, thereby generating abnormally hyperphosphorylated tau species that are similar to paired helical filament-tau found in Alzheimer"s disease.	Proline	126-129	microtubule associated protein tau	Homo sapiens	103-106
7550372-7	1995	This domain consists of a central cluster rich in serine, threonine and proline (STP cluster) flanked by two negatively charged regions containing bulky hydrophobic residues similar to acidic activation domains of Vp1, the herpes simplex virus virion protein VP16 and transcription factors GCN4 and HAP4 from yeast.	Proline	72-79	regulatory protein viviparous-1	Zea mays	214-217
7642558-7	1995	10 microM CNP increased osteoclast bone resorptive activity, measured by the resorption area on whale dentine wafers, or by the NH4Cl-inhibitable release of [3H]proline from radiolabeled bone chips, to 214 and 557% of control, respectively, without affecting osteoclast formation.	Proline	161-168	natriuretic peptide type C	Mus musculus	10-13
7642542-4	1995	This interaction is mediated by the SH3 domains of Grb2 and the proline-rich sequence PPPKIP in the carboxy-terminal region of SAP kinase.	Proline	64-71	growth factor receptor bound protein 2	Homo sapiens	51-55
7495741-5	1995	Interestingly, upstream of the promoter in the antisense strand, an open reading frame has been found that codes for a small molecular weight protein (approximately 60 amino acids) that contains a proline-rich region and a tyrosine-isoleucine motif that has homology to Ig beta (the B29 gene product).	Proline	197-204	CD79B antigen	Mus musculus	270-277
7629138-5	1995	We show that hSos2 interacts with Grb2 via its proline-rich COOH-terminal domain and that this interaction is dependent on the SH3 domains of Grb2.	Proline	47-54	SOS Ras/Rho guanine nucleotide exchange factor 2	Homo sapiens	13-18
7629138-5	1995	We show that hSos2 interacts with Grb2 via its proline-rich COOH-terminal domain and that this interaction is dependent on the SH3 domains of Grb2.	Proline	47-54	growth factor receptor bound protein 2	Homo sapiens	34-38
7644498-0	1995	The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.	Proline	48-55	Yes1 associated transcriptional regulator	Homo sapiens	17-39
7544282-1	1995	The peptide AcAla-Ser-Gln-Lys-Arg-Pro-Ser-Gln-Arg-His-Gly-Ser-Lys-Tyr, which comprises the first 14 residues of the acetylated N-terminus of myelin basic protein, is an epitopic site for two monoclonal antibodies to the human protein.	Proline	34-37	myelin basic protein	Homo sapiens	141-161
7641887-7	1995	Binding assays and site-specific mutagenesis have shown that the proline-rich motif binds with relatively high affinity and specificity to the WW domain of YAP, with a preliminary consensus that is different from the SH3-binding PXXP motif.	Proline	65-72	Yes1 associated transcriptional regulator	Homo sapiens	156-159
7495741-5	1995	Interestingly, upstream of the promoter in the antisense strand, an open reading frame has been found that codes for a small molecular weight protein (approximately 60 amino acids) that contains a proline-rich region and a tyrosine-isoleucine motif that has homology to Ig beta (the B29 gene product).	Proline	197-204	CD79B antigen	Mus musculus	283-286
7559095-2	1995	The wild-type p53 gene has a polymorphism at codon 72 that presents the arginine (CGC) or proline (CCC) genotype, which recently has been reported to be associated with genetically determined susceptibility to smoking-related lung cancers.	Proline	90-97	tumor protein p53	Homo sapiens	14-17
7593830-2	1995	The nature of the interaction of the peptide His98-Pro-His-Pro-His-Leu-Ser-Phe105-Met-Ala-Ile-Pro-Pro- Lys111 with chymosin and porcine pepsin was investigated using molecular modelling and energy minimization techniques.	Proline	51-54	chymosin	Bos taurus	115-123
7473055-9	1995	The membrane proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos and c-myc, and activation of Bruton"s tyrosine and JAK2 kinases.	Proline	22-29	interleukin 5 receptor, alpha	Mus musculus	73-84
7651355-4	1995	The pharmacological specificity, kinetic properties, and ionic requirements of hPROT clearly distinguish this carrier from the other Na(+)-dependent plasma membrane carriers that transport L-proline.	Proline	189-198	solute carrier family 6 member 7	Homo sapiens	79-84
7542745-4	1995	p55PIK is composed of a unique 30-residue NH2 terminus followed by a proline-rich motif and two Src homology 2 (SH2) domains with significant sequence identify to those in p85.	Proline	69-76	phosphoinositide-3-kinase regulatory subunit 3	Mus musculus	0-6
7473055-9	1995	The membrane proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos and c-myc, and activation of Bruton"s tyrosine and JAK2 kinases.	Proline	22-29	interleukin 5	Mus musculus	73-77
7473055-9	1995	The membrane proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos and c-myc, and activation of Bruton"s tyrosine and JAK2 kinases.	Proline	22-29	jun proto-oncogene	Mus musculus	202-207
7473055-9	1995	The membrane proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos and c-myc, and activation of Bruton"s tyrosine and JAK2 kinases.	Proline	22-29	FBJ osteosarcoma oncogene	Mus musculus	209-214
7473055-9	1995	The membrane proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos and c-myc, and activation of Bruton"s tyrosine and JAK2 kinases.	Proline	22-29	Janus kinase 2	Mus musculus	266-270
7624781-5	1995	Alternatively, Pbs2p was activated by a mechanism that involves the binding of its amino terminal proline-rich motif to the Src homology 3 (SH3) domain of a putative transmembrane osmosensor Sho1p.	Proline	98-105	osmosensor SHO1	Saccharomyces cerevisiae S288C	191-196
7473055-10	1995	Furthermore, JAK2 activation correlates with proline residues in Pro-Pro-X-Pro motif in the cytoplasmic domain of IL-5R alpha.	Proline	45-52	Janus kinase 2	Mus musculus	13-17
7473055-10	1995	Furthermore, JAK2 activation correlates with proline residues in Pro-Pro-X-Pro motif in the cytoplasmic domain of IL-5R alpha.	Proline	45-52	interleukin 5 receptor, alpha	Mus musculus	114-125
7624781-5	1995	Alternatively, Pbs2p was activated by a mechanism that involves the binding of its amino terminal proline-rich motif to the Src homology 3 (SH3) domain of a putative transmembrane osmosensor Sho1p.	Proline	98-105	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	15-20
7619799-5	1995	Kinetic analysis of the wild-type and mutant enzymes revealed that the amino acid differences occurring at positions 10 (Val/Ser), 11 (Arg/Pro), and 104 (Val/Gly) are responsible for the reduced enzymatic activity of Gst p-2.	Proline	139-142	glutathione S-transferase, pi 2	Mus musculus	217-224
7624374-1	1995	PR-39 is a porcine 39-aa peptide antibiotic composed of 49% proline and 24% arginine, with an activity against Gram-negative bacteria comparable to that of tetracycline.	Proline	60-67	antibacterial protein PR-39	Sus scrofa	0-5
7628441-0	1995	LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56lck.	Proline	10-17	hematopoietic cell-specific Lyn substrate 1	Homo sapiens	0-6
7628441-0	1995	LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56lck.	Proline	10-17	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	141-147
7628441-3	1995	Analysis of full-length LckBP1 cDNA indicates at least four potentially important segments: a four tandem 37 amino acid repeat motif with a potential helix-turn-helix DNA binding motif; a proline-rich region; a proline-glutamate repeat; and an SH3 domain.	Proline	188-195	hematopoietic cell-specific Lyn substrate 1	Homo sapiens	24-30
7628441-3	1995	Analysis of full-length LckBP1 cDNA indicates at least four potentially important segments: a four tandem 37 amino acid repeat motif with a potential helix-turn-helix DNA binding motif; a proline-rich region; a proline-glutamate repeat; and an SH3 domain.	Proline	211-218	hematopoietic cell-specific Lyn substrate 1	Homo sapiens	24-30
7628441-5	1995	Deletion mutant analysis of LckBP1 revealed two proline-rich regions that permit association with Lck SH3.	Proline	48-55	hematopoietic cell-specific Lyn substrate 1	Homo sapiens	28-34
7628441-5	1995	Deletion mutant analysis of LckBP1 revealed two proline-rich regions that permit association with Lck SH3.	Proline	48-55	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
8530143-8	1995	Ceramide generated by nSMase directs the activation of proline-directed serin/threonine protein kinases and phospholipase A2 and ceramide produced by aSMase triggers the activation of NF-kappa B.	Proline	55-62	sphingomyelin phosphodiesterase 2	Homo sapiens	22-28
8566725-8	1995	The functional activities of two, MP-1 (Phe-Leu-Gly-Phe-Pro-Thr) and MP-2 (Leu-Val-Val-Tyr-Pro-Trp), are being investigated.	Proline	56-59	pitrilysin metallopeptidase 1	Homo sapiens	34-38
7547510-4	1995	Our present study demonstrates that members of the C/EBP and proline and acidic amino acid-rich subfamilies of basic region leucine zipper transcription factors bind the LF-H3 beta site, and cotransfection of HepG2 cells shows that these factors are able to activate an HNF-3 beta promoter reporter construct.	Proline	61-68	forkhead box A2	Homo sapiens	270-280
7789342-13	1995	These results suggest interactions between the extracellular and transmembrane domains of the TSH-R and indicate that this highly conserved proline is required for normal receptor structure and function.	Proline	140-147	thyroid stimulating hormone receptor	Mus musculus	94-99
7622497-0	1995	Inhibition of neurotransmitter release by synthetic proline-rich peptides shows that the N-terminal domain of vesicle-associated membrane protein/synaptobrevin is critical for neuro-exocytosis.	Proline	52-59	synaptobrevin	Aplysia californica	146-159
7622497-4	1995	Structure activity studies showed that this effect is confined to the N-terminal domain of VAMP/synaptobrevin isoform II and is related to the presence of a proline-rich motif (PGGPXGX3PP or PAAPXGX3PP).	Proline	157-164	synaptobrevin	Aplysia californica	96-109
7622497-5	1995	At higher concentrations, the inhibitory effect was lower and only transient, suggesting that the N-terminal proline-rich domain of VAMP/synaptobrevin plays opposing roles in neurotransmitter release very likely by interacting with different synaptic proteins.	Proline	109-116	synaptobrevin	Aplysia californica	137-150
7542592-8	1995	A membrane-proximal proline-rich element of the hIL-5R alpha cytoplasmic domain that is conserved among different members of the hemopoietic cytokine receptor family was essential for biological activity.	Proline	20-27	interleukin 5 receptor subunit alpha	Homo sapiens	48-60
7791764-2	1995	One of the most rapidly tyrosine-phosphorylated polypeptides is the 120-kDa product of the proto-oncogene c-cbl, a cytosolic and cytoskeletal protein containing multiple proline-rich motifs that are potential binding sites for proteins containing Src homology 3 (SH3) domains.	Proline	170-177	Cbl proto-oncogene	Homo sapiens	108-111
7797561-11	1995	Functional dissection of nkx-2.5 revealed a COOH-terminal inhibitory domain composed mainly of clusters of alanines and prolines, which appeared to mask a potent activation domain composed of hydrophobic and highly charged amino acids.	Proline	120-128	NK2 homeobox 5	Mus musculus	25-32
7794921-4	1995	Another mutation, [Ser42--&gt;Pro], was generated in the HS region of r-PC, providing r-[S42P]PC, a change that according to the empirical algorithm based on the Chou-Fasman secondary structure rules, would disrupt the alpha-helical conformation of the HS.	Proline	30-33	RNA 3'-terminal phosphate cyclase	Homo sapiens	70-74
8544900-5	1995	These tau species although having other Ser/Thr-Pro motifs susceptible of phosphorylation by proline-directed protein kinases are not further phosphorylated in vitro by MAP2 kinase whereas the fraction isolated at pH 7.0, which contains underphosphorylated tau species, is phosphorylated.	Proline	48-51	microtubule associated protein tau	Homo sapiens	6-9
7610056-3	1995	Here we report that the C-terminal part of MTF-1 downstream of the DNA binding zinc fingers harbours three different transactivation domains, namely an acidic domain, a proline-rich domain and a domain rich in serine and threonine.	Proline	169-176	metal regulatory transcription factor 1	Homo sapiens	43-48
7610056-7	1995	Another region containing the acidic and proline-rich activation domains also contributes to metal inducibility, but only in the context of intact MTF-1.	Proline	41-48	metal regulatory transcription factor 1	Homo sapiens	147-152
8581741-2	1995	The amino acid sequence deduced from the suf-1 cDNA shares extensive similarity with the su(f) and the human 77K subunit of the CstF, including the proline residues near the carboxy-terminus.	Proline	148-155	Suf domain-containing protein	Caenorhabditis elegans	41-46
7797522-0	1995	The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R.	Proline	56-63	CRK proto-oncogene, adaptor protein	Homo sapiens	18-21
7573176-4	1995	We found in one patient with a history of NMS a nucleotide substitution at codon 310 (CCG-->TCG) of exon 7 of the DRD2 gene which predicts the replacement of proline to serine in the third cytoplasmic loop of the receptor, a part of the receptor that interacts with G-proteins.	Proline	158-165	dopamine receptor D2	Homo sapiens	114-118
7797522-0	1995	The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R.	Proline	56-63	epidermal growth factor receptor pathway substrate 15	Homo sapiens	78-83
7797522-0	1995	The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R.	Proline	56-63	epidermal growth factor receptor pathway substrate 15 like 1	Homo sapiens	88-94
7797522-7	1995	The amino acid sequences of Eps15 and Eps15R featured several proline-rich regions as putative binding motifs for SH3 domains.	Proline	62-69	epidermal growth factor receptor pathway substrate 15	Homo sapiens	28-33
7797522-7	1995	The amino acid sequences of Eps15 and Eps15R featured several proline-rich regions as putative binding motifs for SH3 domains.	Proline	62-69	epidermal growth factor receptor pathway substrate 15 like 1	Homo sapiens	38-44
7797522-8	1995	In both Eps15 and Eps15R, we identified one proline-rich motif which accounts for their interaction with the Crk SH3 domain.	Proline	44-51	epidermal growth factor receptor pathway substrate 15	Homo sapiens	8-13
7797522-8	1995	In both Eps15 and Eps15R, we identified one proline-rich motif which accounts for their interaction with the Crk SH3 domain.	Proline	44-51	epidermal growth factor receptor pathway substrate 15 like 1	Homo sapiens	18-24
7797522-8	1995	In both Eps15 and Eps15R, we identified one proline-rich motif which accounts for their interaction with the Crk SH3 domain.	Proline	44-51	CRK proto-oncogene, adaptor protein	Homo sapiens	109-112
7766824-0	1995	Conformational properties of the proline region of porcine neuropeptide Y by CD and 1H-nmr spectroscopy.	Proline	33-40	neuropeptide Y	Homo sapiens	59-73
7782336-10	1995	GAP-SH3 interaction was also inhibited by the proline-rich peptide GFPPLPPPPPQLPTLG, which corresponds to N-terminal amino acids 129-144 of bovine GAP.	Proline	46-53	RAS p21 protein activator 1	Bos taurus	0-3
7782336-10	1995	GAP-SH3 interaction was also inhibited by the proline-rich peptide GFPPLPPPPPQLPTLG, which corresponds to N-terminal amino acids 129-144 of bovine GAP.	Proline	46-53	RAS p21 protein activator 1	Bos taurus	147-150
7782336-11	1995	An N-terminal deletion mutant of GAP lacking this proline-rich region did not bind to the Hck SH3 domain.	Proline	50-57	RAS p21 protein activator 1	Bos taurus	33-36
7782336-12	1995	These data implicate the Hck SH3 domain in GAP interaction, and suggest a general function for the SH3 domains of Src family kinases in recognition of GAP via its proline-rich N-terminal domain.	Proline	163-170	HCK proto-oncogene, Src family tyrosine kinase	Bos taurus	25-28
7782336-12	1995	These data implicate the Hck SH3 domain in GAP interaction, and suggest a general function for the SH3 domains of Src family kinases in recognition of GAP via its proline-rich N-terminal domain.	Proline	163-170	RAS p21 protein activator 1	Bos taurus	43-46
7782336-12	1995	These data implicate the Hck SH3 domain in GAP interaction, and suggest a general function for the SH3 domains of Src family kinases in recognition of GAP via its proline-rich N-terminal domain.	Proline	163-170	SRC proto-oncogene, non-receptor tyrosine kinase	Bos taurus	114-117
7782336-12	1995	These data implicate the Hck SH3 domain in GAP interaction, and suggest a general function for the SH3 domains of Src family kinases in recognition of GAP via its proline-rich N-terminal domain.	Proline	163-170	RAS p21 protein activator 1	Bos taurus	151-154
7538818-7	1995	Mutant receptors containing Pro-to-Ala substitutions that inactivated the receptor for mitogenic activity also inactivated the receptor for tyrosine-specific phosphorylation of p75.	Proline	28-31	interleukin 2 receptor subunit beta	Homo sapiens	177-180
7781910-7	1995	We show that these five polypeptides are most likely produced by differential usage of a nested set of AUG start codons in the SpGCF1 cDNA and thus contain variable amounts of a proline-rich N-terminal domain.	Proline	178-185	transcription factor GCF1	Strongylocentrotus purpuratus	127-133
7540133-7	1995	Proline 574 might play an important role in the process connecting ATP hydrolysis at the nucleotide binding domain and opening and closing events of the CFTR-Cl- channel.	Proline	0-7	CF transmembrane conductance regulator	Homo sapiens	153-157
7601338-4	1995	The conformational restrictions imposed by proline motifs in a peptide chain appear to imply important structural or biological functions as can be deduced from their often remarkably high degree of conservation as found in many proteins and peptides, especially cytokines, growth factors, G-protein-coupled receptors, V3 loops of the HIV envelope glycoprotein gp 120, and neuro- and vasoactive peptides.	Proline	43-50	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	361-367
7751638-2	1995	According to the peptide motif of HLA-B*3501, aliphatic hydrophobic (Leu, Ile, and Met) or aromatic residues (Tyr and Phe) specify the main anchor at the C terminus, and position 2 renders an auxiliary anchor for proline.	Proline	213-220	major histocompatibility complex, class I, B	Homo sapiens	34-39
7607235-7	1995	This region is consistent with an interdomain region between the cholinesterase-related part of the protein structure and the unique proline-rich C-terminal repeats.	Proline	133-140	butyrylcholinesterase	Homo sapiens	65-79
7542198-8	1995	Polymorphism at position 72 mainly affected peptide/HLA-B7 binding, the proline allele P72 giving a less-reactive peptide (63-73) than the arginine allele R72.	Proline	72-79	DEAD-box helicase 17	Homo sapiens	87-90
7545532-3	1995	The SH1 domain has PTK activity, whilst the SH2 and SH3 domains are involved in mediating protein-protein interactions by binding to phosphotyrosine-containing and proline-rich motifs, respectively.	Proline	164-171	sperm hammerhead 1	Mus musculus	4-7
7545532-3	1995	The SH1 domain has PTK activity, whilst the SH2 and SH3 domains are involved in mediating protein-protein interactions by binding to phosphotyrosine-containing and proline-rich motifs, respectively.	Proline	164-171	sperm hammerhead 2	Mus musculus	44-47
7545532-3	1995	The SH1 domain has PTK activity, whilst the SH2 and SH3 domains are involved in mediating protein-protein interactions by binding to phosphotyrosine-containing and proline-rich motifs, respectively.	Proline	164-171	sperm hammerhead 3	Mus musculus	52-55
7768845-0	1995	The proline-rich P65 protein of Mycoplasma pneumoniae is a component of the Triton X-100-insoluble fraction and exhibits size polymorphism in the strains M129 and FH.	Proline	4-11	cytadherence-associated protein P65	Mycoplasma pneumoniae M129	17-20
7781910-8	1995	Since proline-rich regions often serve as transcriptional activation domains, the five SpGCF1 proteins apparently possess different "activation potentials."	Proline	6-13	transcription factor GCF1	Strongylocentrotus purpuratus	87-93
7549888-5	1995	The analysis revealed an interesting similarity between the segment around the beta 2-strand of alpha-amylase and the one around the beta 4-strand of glycolate oxidase that are flanked in loops by glycines and prolines.	Proline	210-218	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	79-85
7549888-5	1995	The analysis revealed an interesting similarity between the segment around the beta 2-strand of alpha-amylase and the one around the beta 4-strand of glycolate oxidase that are flanked in loops by glycines and prolines.	Proline	210-218	hydroxyacid oxidase 2	Homo sapiens	150-167
7744812-4	1995	Protein binding assays with two Grb2 mutants, Grb2/P49L and Grb2/G203R, which correspond to the loss-of-function mutants in the Caenorhabditis elegans sem-5, demonstrated that the dystroglycan-Grb2 association is through beta-dystroglycan C-terminal proline-rich domains and Grb2 Src homology 3 domains.	Proline	250-257	Sex muscle abnormal protein 5	Caenorhabditis elegans	151-156
7539119-0	1995	Introduction of a loss-of-function point mutation from the SH3 region of the Caenorhabditis elegans sem-5 gene activates the transforming ability of c-abl in vivo and abolishes binding of proline-rich ligands in vitro.	Proline	188-195	Sex muscle abnormal protein 5	Caenorhabditis elegans	100-105
7744836-6	1995	For example, replacement of the P2 proline of Arg-alpha 1-antitrypsin by glycine decreased the association rate constant (kass) with thrombin by 37-fold while the kass value with APC was reduced by only 16-fold.	Proline	35-42	serpin family A member 1	Homo sapiens	50-69
7744812-4	1995	Protein binding assays with two Grb2 mutants, Grb2/P49L and Grb2/G203R, which correspond to the loss-of-function mutants in the Caenorhabditis elegans sem-5, demonstrated that the dystroglycan-Grb2 association is through beta-dystroglycan C-terminal proline-rich domains and Grb2 Src homology 3 domains.	Proline	250-257	Alpha-dystroglycan	Caenorhabditis elegans	180-192
7744836-6	1995	For example, replacement of the P2 proline of Arg-alpha 1-antitrypsin by glycine decreased the association rate constant (kass) with thrombin by 37-fold while the kass value with APC was reduced by only 16-fold.	Proline	35-42	coagulation factor II, thrombin	Homo sapiens	133-141
7744836-11	1995	Substitution of proline for the P2 glycine of this chimeric serpin increased the kass values with thrombin and APC by 7- and 90-fold, respectively.	Proline	16-23	coagulation factor II, thrombin	Homo sapiens	98-106
7774577-2	1995	We have previously identified a highly specific interaction between the first CrkSH3 domain [CrkSH3(1)] and proline-rich sequences in the guanine nucleotide exchange factor C3G.	Proline	108-115	Rap guanine nucleotide exchange factor 1	Homo sapiens	173-176
7752246-3	1995	Docking of the proline-rich peptide, 3BP1 on Grb2-N SH3, shows that the polyproline type II helix can bind the SH3 domain forming conserved hydrogen bonds between the main-chain carbonyl oxygens of Met4 and Pro7 of the proline-rich peptide and the reoriented side-chains of Trp36 and Asn51, respectively, and a hydrogen bond between the main-chain carbonyl of Leu8 of the proline rich peptide with the side-chain OH of Tyr52 of the Grb2-N SH3.	Proline	15-22	SH3 domain binding protein 1	Homo sapiens	37-41
7752246-3	1995	Docking of the proline-rich peptide, 3BP1 on Grb2-N SH3, shows that the polyproline type II helix can bind the SH3 domain forming conserved hydrogen bonds between the main-chain carbonyl oxygens of Met4 and Pro7 of the proline-rich peptide and the reoriented side-chains of Trp36 and Asn51, respectively, and a hydrogen bond between the main-chain carbonyl of Leu8 of the proline rich peptide with the side-chain OH of Tyr52 of the Grb2-N SH3.	Proline	15-22	growth factor receptor bound protein 2	Homo sapiens	432-436
7744754-6	1995	These interactions were not disturbed by deleting the only proline-rich region (amino acids 227-231) in p67phox.	Proline	59-66	neutrophil cytosolic factor 2	Homo sapiens	104-111
7744754-12	1995	We conclude that an interaction between the C-terminal proline-rich region of p47phox and the second SH3 domain of p67phox is not required for oxidase activity in the cell-free assay.	Proline	55-62	neutrophil cytosolic factor 1	Homo sapiens	78-85
7752246-3	1995	Docking of the proline-rich peptide, 3BP1 on Grb2-N SH3, shows that the polyproline type II helix can bind the SH3 domain forming conserved hydrogen bonds between the main-chain carbonyl oxygens of Met4 and Pro7 of the proline-rich peptide and the reoriented side-chains of Trp36 and Asn51, respectively, and a hydrogen bond between the main-chain carbonyl of Leu8 of the proline rich peptide with the side-chain OH of Tyr52 of the Grb2-N SH3.	Proline	15-22	growth factor receptor bound protein 2	Homo sapiens	45-49
7752246-5	1995	The proline-rich peptides could bind the Grb2-N SH3 in either orientation and maintain the key hydrogen bonds because of the pseudo-symmetry of the polyproline type II helix.	Proline	4-11	growth factor receptor bound protein 2	Homo sapiens	41-45
7752246-6	1995	However, for the mSos1 peptide a salt bridge can be formed between the arginine of the proline-rich peptide and the protein at Asp15, Glu16 and Glu31 only in one direction; this orientation seems to be strongly preferred.	Proline	87-94	SOS Ras/Rac guanine nucleotide exchange factor 1	Mus musculus	17-22
7750631-4	1995	The three new AP-2 isoforms all share the same DNA binding/dimerization domain as isoform 1 but either lack the proline-rich transcriptional activation domain encoded by exon 2 (isoform 2) or have different amino-termini encoded by two previously unknown alternative first coding exons for AP-2 (isoforms 3 and 4).	Proline	112-119	transcription factor AP-2, alpha	Mus musculus	14-18
7537736-0	1995	Proline-rich sequence-mediated Jak2 association to the prolactin receptor is required but not sufficient for signal transduction.	Proline	0-7	Janus kinase 2	Homo sapiens	31-35
7537736-0	1995	Proline-rich sequence-mediated Jak2 association to the prolactin receptor is required but not sufficient for signal transduction.	Proline	0-7	prolactin receptor	Homo sapiens	55-73
7537736-5	1995	Our results indicate that interaction between Jak2 and PRLR requires a proline-rich sequence in the membrane proximal region of the receptor, which is conserved among the different members of the cytokine receptor superfamily.	Proline	71-78	Janus kinase 2	Homo sapiens	46-50
7537736-5	1995	Our results indicate that interaction between Jak2 and PRLR requires a proline-rich sequence in the membrane proximal region of the receptor, which is conserved among the different members of the cytokine receptor superfamily.	Proline	71-78	prolactin receptor	Homo sapiens	55-59
7786798-3	1995	The alpha 1(129)(H12)Leu-->Pro substitution disturbs helix H resulting in alpha-thal trait most probably because the unstable alpha-globin chain variant cannot form alpha beta dimers.	Proline	27-30	hemoglobin subunit alpha 2	Homo sapiens	126-138
7583101-11	1995	The listerial ActA polypeptide contains at least two essential sites that are required for efficient microfilament assembly: an amino-terminal 23 amino-acid region for actin filament nucleation, and VASP-binding proline-rich repeats.	Proline	212-219	vasodilator stimulated phosphoprotein	Homo sapiens	199-203
7537275-8	1995	This association with F-actin appeared to be at least partly indirect, since we demonstrated a thrombin-dependent interaction of p85 alpha with a proline-rich sequence of the tyrosine-phosphorylated cytoskeletal focal adhesion kinase, p125FAK.	Proline	146-153	coagulation factor II, thrombin	Homo sapiens	95-103
7537275-8	1995	This association with F-actin appeared to be at least partly indirect, since we demonstrated a thrombin-dependent interaction of p85 alpha with a proline-rich sequence of the tyrosine-phosphorylated cytoskeletal focal adhesion kinase, p125FAK.	Proline	146-153	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	129-138
7537275-9	1995	In addition, we show that PtdIns 3-kinase is significantly activated by the p125FAK proline-rich sequence binding to the src homology 3 domain of p85 alpha subunit.	Proline	84-91	protein tyrosine kinase 2	Homo sapiens	76-83
7565807-0	1995	Identification of three proline-directed phosphorylation sites in the human androgen receptor.	Proline	24-31	androgen receptor	Homo sapiens	76-93
7537275-9	1995	In addition, we show that PtdIns 3-kinase is significantly activated by the p125FAK proline-rich sequence binding to the src homology 3 domain of p85 alpha subunit.	Proline	84-91	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	146-155
7566342-7	1995	Current evidence suggests that protein kinases or protein phosphatases with a specificity for serine/threonine-proline residues play an important role in the hyperphosphorylation of tau.	Proline	111-118	microtubule associated protein tau	Homo sapiens	182-185
7566345-2	1995	Tau can be phosphorylated at many sites and by several kinases, notably by proline-directed kinases (MAPK, GSK-3, cdk5) which generate Alzheimer-like antibody epitopes.	Proline	75-82	cyclin dependent kinase 5	Homo sapiens	114-118
7566346-7	1995	Overall, the hyperphosphorylation of PHF-tau can be considered to consist of fetal-type phosphorylation and additional proline-directed and nonproline-directed phosphorylation.	Proline	119-126	microtubule-associated protein tau	Rattus norvegicus	37-44
7566347-5	1995	Kinases associated with NFT, especially those belonging to the family of proline-directed Ser/Thr kinases, are considered to be important for PHF-tau hyperphosphorylation.	Proline	73-80	microtubule associated protein tau	Homo sapiens	142-149
7753624-6	1995	This domain turned out to be very well conserved amongst homologous alphaherpesvirus regulatory proteins and appeared to be rich in bulky hydrophobic and proline residues, similar to the proline-rich region of the CAAT box binding protein CTF-1.	Proline	154-161	cardiotrophin 1	Homo sapiens	239-244
7489498-4	1995	The N-terminal half of the deduced SF3a120 amino acid sequence contains a tandemly repeated motif (the SURP module) that has recently been identified in the essential splicing factor PRP21p of Saccharomyces cerevisiae, the Drosophila alternative splicing regulator suppressor-of-white-apricot, and four proteins from nematodes and mammals; the C-terminal half is organized into a proline-rich region and a ubiquitin-like domain.	Proline	380-387	splicing factor 3a subunit 1	Homo sapiens	35-42
7489498-4	1995	The N-terminal half of the deduced SF3a120 amino acid sequence contains a tandemly repeated motif (the SURP module) that has recently been identified in the essential splicing factor PRP21p of Saccharomyces cerevisiae, the Drosophila alternative splicing regulator suppressor-of-white-apricot, and four proteins from nematodes and mammals; the C-terminal half is organized into a proline-rich region and a ubiquitin-like domain.	Proline	380-387	Prp21p	Saccharomyces cerevisiae S288C	183-189
7773306-8	1995	These observations suggest that the AtP5CS gene plays a principal role in the biosynthesis of proline in A. thaliana under osmotic stress.	Proline	94-101	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	36-42
7731985-5	1995	Substitution of proline for any of the individual acidic residues (Asp-17 and Glu-21, -24, -25, and -29) eliminated the virion incorporation of Vpr and also altered the stability of Vpr in cells.	Proline	16-23	Vpr	Human immunodeficiency virus 1	144-147
7731985-5	1995	Substitution of proline for any of the individual acidic residues (Asp-17 and Glu-21, -24, -25, and -29) eliminated the virion incorporation of Vpr and also altered the stability of Vpr in cells.	Proline	16-23	Vpr	Human immunodeficiency virus 1	182-185
7537362-1	1995	The molecular interactions of the Src homology 2 (SH2) domain and the N-terminal proline-rich sequence motifs (pro-1 to pro-5) of the SH2 protein Shb with other components were presently characterised.	Proline	81-88	zinc metallopeptidase STE24	Homo sapiens	111-116
7537362-7	1995	However, the GST-SH3 domain fusion proteins tested bind in vitro to peptides corresponding to the pro-1 to pro-5 motifs of Shb with low affinity and selectivity, suggesting that sequences outside the core proline motif may also be important for Shb-SH3 domain interactions.	Proline	205-212	SH2 domain containing adaptor protein B	Homo sapiens	123-126
7753624-6	1995	This domain turned out to be very well conserved amongst homologous alphaherpesvirus regulatory proteins and appeared to be rich in bulky hydrophobic and proline residues, similar to the proline-rich region of the CAAT box binding protein CTF-1.	Proline	187-194	cardiotrophin 1	Homo sapiens	239-244
7537362-1	1995	The molecular interactions of the Src homology 2 (SH2) domain and the N-terminal proline-rich sequence motifs (pro-1 to pro-5) of the SH2 protein Shb with other components were presently characterised.	Proline	81-88	SH2 domain containing adaptor protein B	Homo sapiens	146-149
7537362-1	1995	The molecular interactions of the Src homology 2 (SH2) domain and the N-terminal proline-rich sequence motifs (pro-1 to pro-5) of the SH2 protein Shb with other components were presently characterised.	Proline	81-84	zinc metallopeptidase STE24	Homo sapiens	111-116
7536742-7	1995	Individual residues in MIP were replaced by residues conserved among the Aquaporins, and introduction of a proline in the 5th transmembrane domain of MIP raised the Pf by 50%.	Proline	107-114	major intrinsic protein of lens fiber	Bos taurus	150-153
7537362-1	1995	The molecular interactions of the Src homology 2 (SH2) domain and the N-terminal proline-rich sequence motifs (pro-1 to pro-5) of the SH2 protein Shb with other components were presently characterised.	Proline	81-84	SH2 domain containing adaptor protein B	Homo sapiens	146-149
7537362-7	1995	However, the GST-SH3 domain fusion proteins tested bind in vitro to peptides corresponding to the pro-1 to pro-5 motifs of Shb with low affinity and selectivity, suggesting that sequences outside the core proline motif may also be important for Shb-SH3 domain interactions.	Proline	35-38	zinc metallopeptidase STE24	Homo sapiens	98-103
7537362-7	1995	However, the GST-SH3 domain fusion proteins tested bind in vitro to peptides corresponding to the pro-1 to pro-5 motifs of Shb with low affinity and selectivity, suggesting that sequences outside the core proline motif may also be important for Shb-SH3 domain interactions.	Proline	35-38	SH2 domain containing adaptor protein B	Homo sapiens	123-126
7537362-7	1995	However, the GST-SH3 domain fusion proteins tested bind in vitro to peptides corresponding to the pro-1 to pro-5 motifs of Shb with low affinity and selectivity, suggesting that sequences outside the core proline motif may also be important for Shb-SH3 domain interactions.	Proline	35-38	SH2 domain containing adaptor protein B	Homo sapiens	245-248
7721882-4	1995	We show that in animal cells the "independent" activity of AF-1 is embodied in a rather hydrophobic proline-rich 99-amino acid activating domain (amino acids 51-149), whereas amino acids 51-93 and 102-149 can independently synergize with AF-2.	Proline	100-107	interferon gamma receptor 2	Homo sapiens	59-63
7737110-0	1995	The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.	Proline	4-11	vasodilator stimulated phosphoprotein	Homo sapiens	58-62
7737110-3	1995	The recent molecular cloning of the vasodilator-stimulated phosphoprotein (VASP), an established in vivo substrate of cAMP- and cGMP-dependent protein kinases, revealed the presence of a proline-rich domain which prompted us to investigate a possible interaction with profilins.	Proline	187-194	vasodilator stimulated phosphoprotein	Homo sapiens	36-73
7737110-3	1995	The recent molecular cloning of the vasodilator-stimulated phosphoprotein (VASP), an established in vivo substrate of cAMP- and cGMP-dependent protein kinases, revealed the presence of a proline-rich domain which prompted us to investigate a possible interaction with profilins.	Proline	187-194	vasodilator stimulated phosphoprotein	Homo sapiens	75-79
7737110-5	1995	Here, we demonstrate that VASP is a natural proline-rich profilin ligand.	Proline	44-51	vasodilator stimulated phosphoprotein	Homo sapiens	26-30
7737110-7	1995	Moreover, VASP and a novel protein were specifically extracted from total cell lysates by profilin affinity chromatography and subsequently eluted either with poly-L-proline or a peptide corresponding to a proline-rich VASP motif.	Proline	166-173	vasodilator stimulated phosphoprotein	Homo sapiens	10-14
7536925-5	1995	In contrast, a quite different proline-rich sequence from the Btk protein kinase binds to the Fyn, Lyn, and Hck SH3 domains, but not to the Src SH3.	Proline	31-38	hemopoietic cell kinase	Mus musculus	108-111
7536925-6	1995	Specific binding of the Abl SH3 requires a longer, more proline-rich sequence but no arginine.	Proline	56-63	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	24-27
7718894-8	1995	The GPSAT protein in its mature form should contain 104 amino acid residues and bear a novel sequence, Ser-Glu-Pro-Ala-Pro-Val, encoded by the junction of GPA exon IV and GPB exon V. This sequence interfaces the extracellular and transmembrane domains and could be the epitope site of the SAT antigen.	Proline	111-115	glycophorin A (MNS blood group)	Homo sapiens	4-9
7718894-8	1995	The GPSAT protein in its mature form should contain 104 amino acid residues and bear a novel sequence, Ser-Glu-Pro-Ala-Pro-Val, encoded by the junction of GPA exon IV and GPB exon V. This sequence interfaces the extracellular and transmembrane domains and could be the epitope site of the SAT antigen.	Proline	111-115	glycophorin A (MNS blood group)	Homo sapiens	155-158
7718894-8	1995	The GPSAT protein in its mature form should contain 104 amino acid residues and bear a novel sequence, Ser-Glu-Pro-Ala-Pro-Val, encoded by the junction of GPA exon IV and GPB exon V. This sequence interfaces the extracellular and transmembrane domains and could be the epitope site of the SAT antigen.	Proline	111-115	glycophorin B (MNS blood group)	Homo sapiens	171-174
7718894-8	1995	The GPSAT protein in its mature form should contain 104 amino acid residues and bear a novel sequence, Ser-Glu-Pro-Ala-Pro-Val, encoded by the junction of GPA exon IV and GPB exon V. This sequence interfaces the extracellular and transmembrane domains and could be the epitope site of the SAT antigen.	Proline	111-115	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	6-9
7718575-8	1995	The GCD cleaved the fluorogenic peptides Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 and Dnp-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-NH2 with catalytic efficiency close to full length human gelatinase A.	Proline	45-48	guanylate cyclase 2E, pseudogene	Homo sapiens	4-7
7536925-0	1995	Proline-rich sequences that bind to Src homology 3 domains with individual specificities.	Proline	0-7	Rous sarcoma oncogene	Mus musculus	36-39
7536925-5	1995	In contrast, a quite different proline-rich sequence from the Btk protein kinase binds to the Fyn, Lyn, and Hck SH3 domains, but not to the Src SH3.	Proline	31-38	Fyn proto-oncogene	Mus musculus	94-97
7536925-5	1995	In contrast, a quite different proline-rich sequence from the Btk protein kinase binds to the Fyn, Lyn, and Hck SH3 domains, but not to the Src SH3.	Proline	31-38	LYN proto-oncogene, Src family tyrosine kinase	Mus musculus	99-102
7731697-4	1995	Nucleotide sequence analysis indicated that the MST gene encodes a novel putative non-receptor type of serine/threonine kinase with Src homology 3 (SH3) domain, two leucine zipper domains and proline rich domain.	Proline	192-199	mitogen-activated protein kinase kinase kinase 10	Homo sapiens	48-51
7537361-9	1995	The N-terminal proline-rich region of Shc between A263 and N273 specifically blocked the interaction of p85 SH3 domain with Shc.	Proline	15-22	SHC adaptor protein 1	Homo sapiens	38-41
7537361-9	1995	The N-terminal proline-rich region of Shc between A263 and N273 specifically blocked the interaction of p85 SH3 domain with Shc.	Proline	15-22	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	104-107
7537361-9	1995	The N-terminal proline-rich region of Shc between A263 and N273 specifically blocked the interaction of p85 SH3 domain with Shc.	Proline	15-22	SHC adaptor protein 1	Homo sapiens	124-127
7537212-4	1995	Both bind to the proline-rich C-terminal domain (PRD) of dynamin and inhibit the ability of microtubules and grb2 to stimulate GTPase activity.	Proline	17-24	growth factor receptor bound protein 2	Homo sapiens	109-113
7731697-6	1995	MST is the first non-receptor type of serine/threonine kinase containing SH3 domain, leucine zipper domain and proline rich domain other than PTK1/Sprk.	Proline	111-118	mitogen-activated protein kinase kinase kinase 10	Homo sapiens	0-3
7625762-4	1995	When the entire 780-bp coding region and exon/intron junctions of the DNase I gene of two individuals with phenotypes 1-3 and 2-3 were sequenced, only one nucleotide substitution, a C-G transition (CCC--&gt;GCC), in the codon for amino acid 132 of the mature enzyme located in exon VI was found that resulted in the replacement of proline with alanine (P132A).	Proline	331-338	deoxyribonuclease 1	Homo sapiens	70-77
7633434-0	1995	Rhodopsin mutation proline347-to-alanine in a family with autosomal dominant retinitis pigmentosa indicates an important role for proline at position 347.	Proline	19-26	rhodopsin	Homo sapiens	0-9
7695922-6	1995	These observations were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by autoradiography in HFL-1 cultures labeled with [14C]proline.	Proline	159-166	complement factor H related 1	Homo sapiens	126-131
7706785-1	1995	A fusion gene named LT-B-M5 was constructed encoding the entire B subunit of Escherichia coli labile toxin (LT-B), a 7 amino acid proline-rich linker, and 15 amino-terminal amino acids of type 5 streptococcal M protein.	Proline	130-137	lymphotoxin B	Mus musculus	20-24
7533858-10	1995	However, multiple alanine substitutions or proline (helix-destabilizing) substitutions disrupted both oligomerization and transport of GP64 EFP.	Proline	43-50	gp64	Orgyia pseudotsugata multiple nucleopolyhedrovirus	135-139
7891113-8	1995	Because Ser502, Ser506, Ser603, and Ser666 are all flanked by a carboxyl-terminal proline residue, the results provide further evidence that FA/GSK-3 alpha may represent a proline-directed protein kinase involved in the structure-function regulation of the neuronal cytoskeletal system.	Proline	82-89	glycogen synthase kinase 3 alpha	Homo sapiens	144-155
7643356-3	1995	This new point mutation in exon 2 results in the amino acid substitution of serine for proline in the A-B loop of the transthyretin molecule.	Proline	87-94	transthyretin	Homo sapiens	118-131
7565083-2	1995	Amino acid changes Val-219-Asp and Ala-220-Pro, introducing a proline kink at the hinge region between the N-terminal A domain and the central portion of XylR, resulted in a semi-constitutive phenotype which mimicked the activating effect of aromatic inducers.	Proline	62-69	xylose operon regulatory protein	Pseudomonas putida	154-158
7613025-6	1995	This novel gene, named Gnb5, for guanine nucleotide-binding protein, beta 5, codes for a protein of 538 amino acids with a highly acidic amino terminus containing a proline-rich domain, followed by a neutral domain with five repeat units of the beta-transducin (WD-40) motif.	Proline	165-172	guanine nucleotide-binding protein subunit beta-5	Mesocricetus auratus	23-27
7613025-6	1995	This novel gene, named Gnb5, for guanine nucleotide-binding protein, beta 5, codes for a protein of 538 amino acids with a highly acidic amino terminus containing a proline-rich domain, followed by a neutral domain with five repeat units of the beta-transducin (WD-40) motif.	Proline	165-172	telomerase Cajal body protein 1	Mesocricetus auratus	33-75
7891726-5	1995	The participation of nitrogen repression and the regulators GLN3 and URE2 in the proline utilization pathway was evaluated in this study.	Proline	81-88	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	60-64
7891726-5	1995	The participation of nitrogen repression and the regulators GLN3 and URE2 in the proline utilization pathway was evaluated in this study.	Proline	81-88	glutathione peroxidase	Saccharomyces cerevisiae S288C	69-73
7891726-8	1995	Although PUT3, the proline utilization pathway transcriptional activator, is absolutely required for growth on proline as the sole nitrogen source, a put3 ure2 strain had somewhat elevated PUT gene expression, suggesting an effect of the ure2 mutation in the absence of the PUT3 product.	Proline	19-26	Put3p	Saccharomyces cerevisiae S288C	9-13
7891726-8	1995	Although PUT3, the proline utilization pathway transcriptional activator, is absolutely required for growth on proline as the sole nitrogen source, a put3 ure2 strain had somewhat elevated PUT gene expression, suggesting an effect of the ure2 mutation in the absence of the PUT3 product.	Proline	111-118	Put3p	Saccharomyces cerevisiae S288C	9-13
7753049-9	1995	Redesigning several versions with alterations in FR1 and FR2 revealed that the Pro-46 residue was the only critical residue for creating an antigen binding site.	Proline	79-82	aldo-keto reductase family 1, member B8	Mus musculus	49-52
7535773-9	1995	GH had no effect on SHC phosphorylation in cells expressing GHR1-294 or GHR delta P, the latter lacking amino acids 297-311 containing the proline-rich motif required for JAK2 activation by GH.	Proline	139-146	Janus kinase 2	Homo sapiens	171-175
7708714-5	1995	Mutation of the four proline residues in the conserved box 1 region of the GHR, which is responsible for binding and activation of JAK2 kinase, completely abolished GH-induced gene transcription but did not affect the GH-induced rise in [Ca2+]i.	Proline	21-28	growth hormone receptor	Homo sapiens	75-78
7706310-5	1995	In the presence of p45, MafK confers site-specific DNA binding activity to p45, and p45 in turn mediates transcriptional activation with its amino-terminal proline-rich domain.	Proline	156-163	nuclear factor, erythroid derived 2	Mus musculus	19-22
7706310-5	1995	In the presence of p45, MafK confers site-specific DNA binding activity to p45, and p45 in turn mediates transcriptional activation with its amino-terminal proline-rich domain.	Proline	156-163	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	Mus musculus	24-28
7706310-5	1995	In the presence of p45, MafK confers site-specific DNA binding activity to p45, and p45 in turn mediates transcriptional activation with its amino-terminal proline-rich domain.	Proline	156-163	nuclear factor, erythroid derived 2	Mus musculus	75-78
7706310-5	1995	In the presence of p45, MafK confers site-specific DNA binding activity to p45, and p45 in turn mediates transcriptional activation with its amino-terminal proline-rich domain.	Proline	156-163	nuclear factor, erythroid derived 2	Mus musculus	75-78
7708714-5	1995	Mutation of the four proline residues in the conserved box 1 region of the GHR, which is responsible for binding and activation of JAK2 kinase, completely abolished GH-induced gene transcription but did not affect the GH-induced rise in [Ca2+]i.	Proline	21-28	Janus kinase 2	Homo sapiens	131-135
7708714-5	1995	Mutation of the four proline residues in the conserved box 1 region of the GHR, which is responsible for binding and activation of JAK2 kinase, completely abolished GH-induced gene transcription but did not affect the GH-induced rise in [Ca2+]i.	Proline	21-28	growth hormone 1	Homo sapiens	75-77
7708714-5	1995	Mutation of the four proline residues in the conserved box 1 region of the GHR, which is responsible for binding and activation of JAK2 kinase, completely abolished GH-induced gene transcription but did not affect the GH-induced rise in [Ca2+]i.	Proline	21-28	growth hormone 1	Homo sapiens	165-167
7737192-7	1995	This proline-rich region arises due to an unusual reading-frame shift in the PAX8 transcript.	Proline	5-12	paired box 8	Homo sapiens	77-81
7729684-7	1995	Mouse p57KIP2 consists of four structurally distinct domains: an amino-terminal Cdk inhibitory domain, a proline-rich domain, an acidic-repeat region, and a carboxy-terminal domain conserved with p27KIP1.	Proline	105-112	cyclin-dependent kinase inhibitor 1C (P57)	Mus musculus	6-13
7729684-8	1995	Human p57KIP2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats.	Proline	144-151	cyclin dependent kinase inhibitor 1C	Homo sapiens	6-13
7534286-4	1995	A full-length length cDNA encoding human paxillin was cloned, revealing multiple protein domains, including four tandem LIM domains, a proline-rich domain containing a consensus SH3 binding site, and three potential Crk-SH2 binding sites.	Proline	135-142	paxillin	Homo sapiens	41-49
7887899-8	1995	The proline-rich peptides flanking the vWF A1 loop, Cys474-Val489 and Leu694-Asp709, inhibited vWF binding semispecifically by competitively interfering with the formation of the GPIb-vWF complex rather than by complexation of free ristocetin dimers.	Proline	4-11	von Willebrand factor	Homo sapiens	39-42
7887899-8	1995	The proline-rich peptides flanking the vWF A1 loop, Cys474-Val489 and Leu694-Asp709, inhibited vWF binding semispecifically by competitively interfering with the formation of the GPIb-vWF complex rather than by complexation of free ristocetin dimers.	Proline	4-11	von Willebrand factor	Homo sapiens	95-98
7887899-8	1995	The proline-rich peptides flanking the vWF A1 loop, Cys474-Val489 and Leu694-Asp709, inhibited vWF binding semispecifically by competitively interfering with the formation of the GPIb-vWF complex rather than by complexation of free ristocetin dimers.	Proline	4-11	von Willebrand factor	Homo sapiens	95-98
7887899-9	1995	In conclusion, ristocetin-promoted binding of vWF to its GPIb receptor results from charge neutralization and interactions involving proline residues in the vicinity of the natural interaction sites present on both GPIb and the A1 domain of vWF.	Proline	133-140	von Willebrand factor	Homo sapiens	46-49
7887902-0	1995	Variations in in vivo phosphorylation at the proline-rich domain of the microtubule-associated protein 2 (MAP2) during rat brain development.	Proline	45-52	microtubule-associated protein 2	Rattus norvegicus	72-104
7887902-0	1995	Variations in in vivo phosphorylation at the proline-rich domain of the microtubule-associated protein 2 (MAP2) during rat brain development.	Proline	45-52	microtubule-associated protein 2	Rattus norvegicus	106-110
7887902-4	1995	An antibody (972) raised against this non-phosphorylated peptide has been used to test for in vivo phosphorylation at the proline-rich domain of the MAP2 molecule.	Proline	122-129	microtubule-associated protein 2	Rattus norvegicus	149-153
7763334-7	1995	Current evidence suggests that protein kinases or protein phosphatases with a specificity for serine/threonine-proline residues are instrumental in the hyperphosphorylation of tau.	Proline	111-118	microtubule associated protein tau	Homo sapiens	176-179
7887902-7	1995	There is some variation in the phosphorylation of MAP2 at the proline-rich region throughout rat brain development.	Proline	62-69	microtubule-associated protein 2	Rattus norvegicus	50-54
7735837-0	1995	Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk.	Proline	67-74	cyclin dependent kinase 20	Homo sapiens	123-128
7535279-2	1995	We report that the ena protein contains proline-rich motifs and binds to Abl and Src SH3 domains, ena is also a substrate for the Abl kinase; tyrosine phosphorylation of ena is increased when it is coexpressed in cells with human or Drosophila Abl and endogenous ena tyrosine phosphorylation is reduced in Abl mutant animals.	Proline	40-47	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	73-76
7535279-2	1995	We report that the ena protein contains proline-rich motifs and binds to Abl and Src SH3 domains, ena is also a substrate for the Abl kinase; tyrosine phosphorylation of ena is increased when it is coexpressed in cells with human or Drosophila Abl and endogenous ena tyrosine phosphorylation is reduced in Abl mutant animals.	Proline	40-47	Abl tyrosine kinase	Drosophila melanogaster	130-133
7535279-2	1995	We report that the ena protein contains proline-rich motifs and binds to Abl and Src SH3 domains, ena is also a substrate for the Abl kinase; tyrosine phosphorylation of ena is increased when it is coexpressed in cells with human or Drosophila Abl and endogenous ena tyrosine phosphorylation is reduced in Abl mutant animals.	Proline	40-47	Abl tyrosine kinase	Drosophila melanogaster	130-133
7535279-2	1995	We report that the ena protein contains proline-rich motifs and binds to Abl and Src SH3 domains, ena is also a substrate for the Abl kinase; tyrosine phosphorylation of ena is increased when it is coexpressed in cells with human or Drosophila Abl and endogenous ena tyrosine phosphorylation is reduced in Abl mutant animals.	Proline	40-47	Abl tyrosine kinase	Drosophila melanogaster	130-133
7775860-12	1995	However, it retained the general organization common to all known apoA-Is, i.e., a series of amphipathic helical segments punctuated by proline residues.	Proline	136-143	apolipoprotein A1	Homo sapiens	66-70
7709430-2	1995	Until recently, ERK1 and ERK2 were the only cloned and well-characterized mammalian MAPKs; diverse ligand-stimulated, proline-directed protein phosphorylation events were attributed to these kinases.	Proline	118-125	mitogen-activated protein kinase 3	Homo sapiens	16-20
7709430-2	1995	Until recently, ERK1 and ERK2 were the only cloned and well-characterized mammalian MAPKs; diverse ligand-stimulated, proline-directed protein phosphorylation events were attributed to these kinases.	Proline	118-125	mitogen-activated protein kinase 1	Homo sapiens	25-29
7875321-5	1995	The amino-terminal domain of hamster galectin 3, which is a repetitive sequence rich in glutamine, tyrosine, glycine and proline, is also an excellent substrate.	Proline	121-128	galectin 3	Homo sapiens	37-47
7759311-5	1995	DQA1*0502 represents a single C-to-G transversion in codon 59 (exon 2) and results in an amino acid change from proline to arginine.	Proline	112-119	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	0-4
9222987-1	1995	We report 104 analogues of the potent antiovulatory antagonist of LHRH, N-Ac-D-Nal-D-Cpa-D-Pal-Ser-Lys(Nic)-D-Lys(Nic)-Leu-Ilys-Pro-D-Ala- NH2, Antide.	Proline	128-131	gonadotropin releasing hormone 1	Rattus norvegicus	66-70
7862126-3	1995	The interaction between Vav and hnRNP K involves the binding of the most carboxy-terminal SH3 domain of Vav to two proline-rich sequences present in the central region of hnRNP K.	Proline	115-122	vav 1 oncogene	Mus musculus	24-27
7862126-3	1995	The interaction between Vav and hnRNP K involves the binding of the most carboxy-terminal SH3 domain of Vav to two proline-rich sequences present in the central region of hnRNP K.	Proline	115-122	heterogeneous nuclear ribonucleoprotein K	Mus musculus	32-39
7862126-3	1995	The interaction between Vav and hnRNP K involves the binding of the most carboxy-terminal SH3 domain of Vav to two proline-rich sequences present in the central region of hnRNP K.	Proline	115-122	vav 1 oncogene	Mus musculus	104-107
7862126-3	1995	The interaction between Vav and hnRNP K involves the binding of the most carboxy-terminal SH3 domain of Vav to two proline-rich sequences present in the central region of hnRNP K.	Proline	115-122	heterogeneous nuclear ribonucleoprotein K	Mus musculus	171-178
7634492-3	1995	L-Proline which is known to dissociate Lp(a) from other apo B-containing lipoproteins improved the results considerably.	Proline	0-9	lipoprotein(a)	Homo sapiens	39-44
7876130-4	1995	We show that the residues 4 and 5 amino acids COOH-terminal to Tyr1021 (+4 Leu and +5 Pro) are required for efficient PLC-gamma 1 binding, and that their replacement with the corresponding residues from a phosphatidylinositol 3"-kinase binding site abrogates stable association with PLC-gamma 1.	Proline	86-89	phospholipase C gamma 1	Homo sapiens	118-129
7876130-4	1995	We show that the residues 4 and 5 amino acids COOH-terminal to Tyr1021 (+4 Leu and +5 Pro) are required for efficient PLC-gamma 1 binding, and that their replacement with the corresponding residues from a phosphatidylinositol 3"-kinase binding site abrogates stable association with PLC-gamma 1.	Proline	86-89	phospholipase C gamma 1	Homo sapiens	283-294
7761629-7	1995	The amino acid sequence of sturgeon GnRH is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2.	Proline	77-80	gonadotropin releasing hormone 1	Homo sapiens	36-40
7735837-1	1995	BACKGROUND: Proline-rich segments in the guanine nucleotide exchange factor C3G bind much more strongly to the N-terminal Src homology 3 domain (SH3-N) of the proto-oncogene product c-Crk than to other SH3 domains.	Proline	12-19	Rap guanine nucleotide exchange factor 1	Homo sapiens	76-79
7735837-1	1995	BACKGROUND: Proline-rich segments in the guanine nucleotide exchange factor C3G bind much more strongly to the N-terminal Src homology 3 domain (SH3-N) of the proto-oncogene product c-Crk than to other SH3 domains.	Proline	12-19	cyclin dependent kinase 20	Homo sapiens	182-187
7859737-0	1995	Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.	Proline	0-7	Nef	Human immunodeficiency virus 1	36-39
7621613-8	1995	However, this effect was only partially abolished in the presence of 10(-6) g/mL of the ACE-I, which was the maximal concentration that did not exert any effect on the [3H]-proline uptake.	Proline	173-180	angiotensin I converting enzyme	Rattus norvegicus	88-91
7851528-0	1995	Effect of the C-terminal proline repeats on ordered packing of squid rhodopsin and its mobility in membranes.	Proline	25-32	rhodopsin	Homo sapiens	69-78
7851528-2	1995	The C-terminus of squid rhodopsin contains a negatively charged region followed by 9-10 repeats of a proline-rich sequence, not found in rhodopsins other than those of cephalopod invertebrates, but similar proline repeats are found in other, unrelated membrane proteins.	Proline	101-108	rhodopsin	Homo sapiens	24-33
7833484-4	1995	It is a C--&gt;G transition at nucleotide position 676, which leads to an amino acid substitution from proline to alanine in the Rh e-carrying polypeptide.	Proline	103-110	factor interacting with PAPOLA and CPSF1	Homo sapiens	129-133
9383409-3	1995	The first mutations to be detected were found in two sporadic cases that had identical Arg to Pro changes within one EGF-like domain.	Proline	94-97	epidermal growth factor	Homo sapiens	117-120
7859737-0	1995	Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.	Proline	0-7	Nef	Human immunodeficiency virus 1	131-134
7829876-1	1995	In this report, the pancornulins are identified as members of the spr (small, proline-rich) multigene family by amino acid sequence and mass spectrometry analyses.	Proline	78-85	sepiapterin reductase	Homo sapiens	66-69
7767781-7	1995	For gastricsin the sequence differed from the pepsin isoenzymes and in position 24 we find pro rather than ala as was first described.	Proline	91-94	progastricsin	Homo sapiens	4-14
7596309-6	1995	Yet another finding is the occurrence of several sequences of the form serine-proline-X-X and/or threonine-proline-X-X in the hinge sections of IgA and IgG3.	Proline	78-85	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	152-156
7596309-6	1995	Yet another finding is the occurrence of several sequences of the form serine-proline-X-X and/or threonine-proline-X-X in the hinge sections of IgA and IgG3.	Proline	107-114	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	152-156
7823952-4	1995	Utilizing a series of truncated Msx-1 polypeptides, we show that multiple regions of Msx-1 contribute to repression, and these are rich in alanine, glycine, and proline residues.	Proline	161-168	msh homeobox 1	Mus musculus	32-37
7823952-4	1995	Utilizing a series of truncated Msx-1 polypeptides, we show that multiple regions of Msx-1 contribute to repression, and these are rich in alanine, glycine, and proline residues.	Proline	161-168	msh homeobox 1	Mus musculus	85-90
7823951-3	1995	First, in vivo and in vitro analyses have been used to demonstrate that the level of activation by EKLF is dependent on the orientation and number of CACCC elements, that EKLF contains separable activation and DNA-binding domains, and that the EKLF proline-rich region is a potent activator in CV-1 cells when fused to a nonrelated DNA-binding module.	Proline	249-256	Kruppel-like factor 1 (erythroid)	Mus musculus	99-103
7851422-0	1995	Functional consequences of proline mutations in the putative transmembrane segments 6 and 10 of the glucose transporter GLUT1.	Proline	27-34	solute carrier family 2 member 1	Homo sapiens	120-125
7851394-7	1995	The glutaredoxin sequence comprised the classical active site for glutaredoxins -Cys22-Pro-Tyr-Cys25- and three additional half-cystine residues; two of these in positions 78 and 82.	Proline	87-90	glutaredoxin	Homo sapiens	4-16
7531159-0	1995	Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-proline-dependent protein kinases and GSK-3.	Proline	78-85	microtubule associated protein tau	Homo sapiens	40-43
7531159-1	1995	Tau protein from Alzheimer disease (AD) brain is phosphorylated at eleven Ser/Thr-Pro and nine Ser/Thr-X sites.	Proline	82-85	microtubule associated protein tau	Homo sapiens	0-3
7851396-5	1995	This prolyl endopeptidase activity was shown to have a molecular mass (87 kDa) higher than the cytosolic prolyl endopeptidase but, from initial investigation, appears to demonstrate a similarly broad substrate specificity towards proline-containing neuropeptides.	Proline	230-237	prolyl endopeptidase	Bos taurus	5-25
7851422-5	1995	Proline residues of helix 6, that are conserved in all human glucose-transporter isoforms except for the human GLUT2, were mutated either to alanine or to the corresponding residues of GLUT2, i.e. to histidine (P187H), arginine (P196R) or phenylalanine (P205F).	Proline	0-7	solute carrier family 2 member 2	Homo sapiens	185-190
7851396-5	1995	This prolyl endopeptidase activity was shown to have a molecular mass (87 kDa) higher than the cytosolic prolyl endopeptidase but, from initial investigation, appears to demonstrate a similarly broad substrate specificity towards proline-containing neuropeptides.	Proline	230-237	prolyl endopeptidase	Bos taurus	105-125
7822317-0	1995	Proline-directed and non-proline-directed phosphorylation of PHF-tau.	Proline	0-7	microtubule associated protein tau	Homo sapiens	61-68
7819190-1	1995	The Pf1 gene 5 protein forms a large helical nucleoprotein complex (Mr = 3.1 x 10(7)) with single-stranded viral DNA, from which a 32 amino acid sequence rich in alanine, proline, and glutamine residues can be removed from the C-terminus by limited proteolysis.	Proline	171-178	PHD finger protein 12	Homo sapiens	4-7
7822317-0	1995	Proline-directed and non-proline-directed phosphorylation of PHF-tau.	Proline	25-32	microtubule associated protein tau	Homo sapiens	61-68
7822317-5	1995	Thus, the abnormal phosphorylation of PHF-tau can be considered to consist of fetal type phosphorylation and additional proline-directed and non-proline-directed phosphorylation.	Proline	120-127	microtubule associated protein tau	Homo sapiens	38-45
7822317-5	1995	Thus, the abnormal phosphorylation of PHF-tau can be considered to consist of fetal type phosphorylation and additional proline-directed and non-proline-directed phosphorylation.	Proline	145-152	microtubule associated protein tau	Homo sapiens	38-45
7840241-7	1995	Endogenous (membrane-bound) CaMK II and PKC, as well as exogenous, highly purified PKC inhibited NaCl-linked proline uptake by phosphorylated, lysed/resealed BBMV compared with control vesicles.	Proline	109-116	protein kinase C, gamma	Rattus norvegicus	40-43
7837225-2	1995	To further explore the structural requirements of the Met31 side chain in the receptor-bound conformation of CCK4, we have synthesized several Ac-CCK4 analogs containing substitution of Met31 by 3- and 4-(alkylthio)-substituted proline derivatives.	Proline	228-235	protein tyrosine kinase 7 (inactive)	Homo sapiens	109-113
7840241-7	1995	Endogenous (membrane-bound) CaMK II and PKC, as well as exogenous, highly purified PKC inhibited NaCl-linked proline uptake by phosphorylated, lysed/resealed BBMV compared with control vesicles.	Proline	109-116	protein kinase C, gamma	Rattus norvegicus	83-86
7840241-9	1995	The CaMK II- and PKC-induced inhibition of proline uptake was reversed by the specific kinase inhibitor peptides CaMK II-(281-302) and PKC-(19-31), respectively.	Proline	43-50	protein kinase C, gamma	Rattus norvegicus	17-20
7840241-9	1995	The CaMK II- and PKC-induced inhibition of proline uptake was reversed by the specific kinase inhibitor peptides CaMK II-(281-302) and PKC-(19-31), respectively.	Proline	43-50	protein kinase C, gamma	Rattus norvegicus	135-138
7748973-1	1995	Prolidase (EC: 3.4.13.9) catalyses the hydrolysis of the peptide bond involving the imino nitrogen of proline or hydroxyproline.	Proline	102-109	peptidase D	Homo sapiens	0-9
7677406-9	1995	A proline-rich juxtamembranous sequence, called Box 1, is important for GH effects on gene transcription, on MAP kinase activity, on cell proliferation, and on JAK2 activation.	Proline	2-9	Janus kinase 2	Homo sapiens	160-164
7605205-3	1995	Ts 451 also has a single base substitution (U273--&gt;C) leading to an amino acid replacement (Ser 83--&gt;Pro) in the NS1 protein.	Proline	107-110	influenza virus NS1A binding protein	Homo sapiens	119-122
7775381-7	1995	IHRP was readily cleaved into 85- and 35-kDa fragments when plasma was incubated at 37 degrees C. The cleaved site, Arg-Arg-Leu, was within a proline-rich region.	Proline	142-149	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	0-4
7626788-6	1995	As its mouse and human counterparts, the ovine p53 contains a high proportion of proline residues, an acidic N-terminal domain and a basic C-terminal domain.	Proline	81-88	tumor protein p53	Homo sapiens	47-50
7655111-2	1995	Their gene products encode proteins involved in the regulation of cell growth (proto-oncogenes c-myc and c-fos), a gene inducible by growth arrest and DNA damage (GADD153), the cytokine interleukin (IL) 1 alpha and beta and finally a differentiation-associated small proline-rich gene (SPR2).	Proline	267-274	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	95-100
7655111-2	1995	Their gene products encode proteins involved in the regulation of cell growth (proto-oncogenes c-myc and c-fos), a gene inducible by growth arrest and DNA damage (GADD153), the cytokine interleukin (IL) 1 alpha and beta and finally a differentiation-associated small proline-rich gene (SPR2).	Proline	267-274	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-110
7655111-2	1995	Their gene products encode proteins involved in the regulation of cell growth (proto-oncogenes c-myc and c-fos), a gene inducible by growth arrest and DNA damage (GADD153), the cytokine interleukin (IL) 1 alpha and beta and finally a differentiation-associated small proline-rich gene (SPR2).	Proline	267-274	DNA damage inducible transcript 3	Homo sapiens	163-170
7828849-6	1995	One of those genes (DAP-1) is expressed as a single 2.4-kb mRNA that codes for a basic, proline-rich, 15-kD protein.	Proline	88-95	death associated protein	Homo sapiens	20-25
7696559-8	1995	The structures observed in TFE suggest that the Thr-Pro sequence initiates short helical segments in TPAKK motifs, and these helical structures might interact with nucleic acids, presumably via interactions between lysines and threonines of nucleolin.	Proline	52-55	nucleolin	Homo sapiens	241-250
11322345-6	1995	Moreover, a mixture (1:1 v/v) of the DMEM mineralisation medium with Ham"s medium (in which the aminoacid proline abounds) was found to accelerate, in comparison to DMEM alone, the intracellular type I procollagen synthesis, the extracellular assembly of type I collagen fibrils, and the calcification of the extracellular matrix by the human osteoblasts.	Proline	106-113	collagen type I alpha 2 chain	Homo sapiens	195-213
7838130-3	1995	During the study of the structure-activity relationships for IL-2 and its receptors, one analog in which threonines at positions 41 and 51 were replaced by prolines (T41/51P) was found to possess apparent signaling abnormalities.	Proline	156-164	interleukin 2	Homo sapiens	61-65
7714915-4	1995	Evidence is presented showing that proline starvation produces a state of cellular stress which results in a burst of mutations from trpA46 to trpA+ when proline-starved cells are plated onto medium lacking tryptophan but containing proline.	Proline	35-42	tryptase gamma 1	Homo sapiens	133-137
7714915-4	1995	Evidence is presented showing that proline starvation produces a state of cellular stress which results in a burst of mutations from trpA46 to trpA+ when proline-starved cells are plated onto medium lacking tryptophan but containing proline.	Proline	154-161	tryptase gamma 1	Homo sapiens	133-137
7714915-4	1995	Evidence is presented showing that proline starvation produces a state of cellular stress which results in a burst of mutations from trpA46 to trpA+ when proline-starved cells are plated onto medium lacking tryptophan but containing proline.	Proline	154-161	tryptase gamma 1	Homo sapiens	133-137
8713173-0	1995	Regional hemodynamic changes and vasopressin release induced by intracisternal injection of L-proline in the conscious rat.	Proline	92-101	arginine vasopressin	Rattus norvegicus	33-44
8713173-6	1995	In addition, pretreatment with the vasopressin antagonist alone almost abolished the pressor and vasoconstrictor action induced by L-proline injection.	Proline	131-140	arginine vasopressin	Rattus norvegicus	35-46
8584672-3	1995	Both lysyl oxidase and SSAO catalyze the oxidation of tyramine with removal of the pro-S hydrogen from C-1 of this substrate.	Proline	83-88	amine oxidase copper containing 3	Homo sapiens	23-27
8584672-4	1995	The copper amine oxidase enzymes that react with abstraction of the pro-S hydrogen from C-1 of substrates do not exhibit a solvent exchange pathway.	Proline	68-73	amine oxidase copper containing 3	Homo sapiens	4-24
7986086-2	1994	Replacement of the proline residue by any of the other 19 amino acids or D-proline drastically reduces or abolishes phosphorylation by CDC2.	Proline	19-26	cyclin dependent kinase 1	Homo sapiens	135-139
7806500-0	1994	Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk.	Proline	5-12	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	70-73
7806500-5	1994	The center region of the 145-155-kDa protein contains four similar proline-rich sequences which are capable of binding individually to the SH3(N) domains of c-Crk and v-Crk.	Proline	67-74	v-crk avian sarcoma virus CT10 oncogene homolog	Mus musculus	157-162
7806500-6	1994	Comparison of these sequences in C3G to proline-rich sequences in other Crk-binding proteins suggests that positively charged amino acids following the prolines play an important role in the binding to the CrkSH3(N) domain.	Proline	40-47	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	33-36
7806500-6	1994	Comparison of these sequences in C3G to proline-rich sequences in other Crk-binding proteins suggests that positively charged amino acids following the prolines play an important role in the binding to the CrkSH3(N) domain.	Proline	152-160	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	33-36
7717919-2	1994	A proline to leucine change due to a C to T transition in codon 622 of hMSH2 has been identified in a large HNPCC family of over 240 individuals.	Proline	2-9	mutS homolog 2	Homo sapiens	71-76
7994916-5	1994	Frequency analysis of the relative occurrence of the 20 amino acids in the nanopeptides displayed by 50 random bacteriophages picked before selection and 63 after selection to bind to TNF-alpha autoantibodies indicated that proline (P &lt; 0.0003) and serine (P &lt; 0.04) are involved in the binding of the autoantibodies to the phages.	Proline	224-231	tumor necrosis factor	Homo sapiens	184-193
8001233-8	1994	However, sequence analysis did reveal that the three GPX1 alleles were characterized by three nucleotide substitutions in addition to the polyalanine polymorphism, including a substitution at codon 198 which results in either a proline or leucine at that position.	Proline	228-235	glutathione peroxidase 1	Homo sapiens	53-57
7840772-6	1994	The docking involves the interaction of SH3 domains on p47-phox or p67-phox with a proline-rich sequence on the small subunit of the cytochrome b.	Proline	83-90	neutrophil cytosolic factor 1	Homo sapiens	55-63
7840772-6	1994	The docking involves the interaction of SH3 domains on p47-phox or p67-phox with a proline-rich sequence on the small subunit of the cytochrome b.	Proline	83-90	CD33 molecule	Homo sapiens	67-70
7840772-6	1994	The docking involves the interaction of SH3 domains on p47-phox or p67-phox with a proline-rich sequence on the small subunit of the cytochrome b.	Proline	83-90	mitochondrially encoded cytochrome b	Homo sapiens	133-145
7872059-4	1994	The prostaglandin F receptor (FP) selective agonist, fluprostenol, was the most potent agonist tested, significantly inhibiting incorporation of [3H]proline into both collagen and noncollagen protein at 10(-11) M, with more than 90% inhibition of collagen synthesis at 10(-8) M. The PGE2 analog, sulprostone, and PGD2 showed activity similar to that of PGE2.	Proline	149-156	prostaglandin F receptor	Rattus norvegicus	4-28
7988556-9	1994	We find that although the phage-displayed Abl and Src SH3 ligands are proline rich, they are distinct.	Proline	70-77	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	42-45
7988556-9	1994	We find that although the phage-displayed Abl and Src SH3 ligands are proline rich, they are distinct.	Proline	70-77	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	50-53
7737696-7	1994	The N-terminal sequence also carries a proline/serine rich putative SH3 binding domain, consistent with a role for tyrosine kinases in regulating Nramp function.	Proline	39-46	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	146-151
7705764-2	1994	To overcome these problems, the short-acting human insulin analogue [LYS(B28),PRO(B29)] (LYSPRO) was developed.	Proline	78-81	insulin	Homo sapiens	51-58
7969158-8	1994	A proline-rich region of MEK-1 containing a phosphorylation site appears to be essential for signalling complex formation.	Proline	2-9	mitogen-activated protein kinase kinase 1	Homo sapiens	25-30
7798612-9	1994	Sequence comparison among the allele products associated with AA indicates that the DQB1*03 alleles carry a unique proline at position 55 that is not present in alleles that are neutral or negatively associated with the disease.	Proline	115-122	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	84-88
7707359-8	1994	The calpain binding site is identified as a PEST (proline, glutamic acid, serine, threonine-rich) region in the amino acid sequence GTPGGTPQPGVE, at positions 1356-1367 of the RyR and the cleavage site, the calmodulin binding site, at residues 1383-1400.	Proline	50-57	ryanodine receptor 1	Homo sapiens	176-179
7808408-3	1994	We have found that the Om(2D) gene encodes a novel protein containing histidine/proline repeats, and is ubiquitously expressed during embryogenesis.	Proline	80-87	protein Teyrha-meyrha	Drosophila ananassae	23-28
7964505-3	1994	This mutation leads to a substitution at residue 156 of a proline into a glutamine in a putative SH3 binding domain of p22-phox (Dinauer, M., E. A.	Proline	58-65	cytochrome b-245 alpha chain	Homo sapiens	119-127
7526158-3	1994	We demonstrate here that Tec, a cytoplasmic, src-related kinase, physically associates with c-kit through a region that contains a proline-rich motif, amino terminal of the SH3 domain.	Proline	131-138	tec protein tyrosine kinase	Homo sapiens	25-28
7526158-3	1994	We demonstrate here that Tec, a cytoplasmic, src-related kinase, physically associates with c-kit through a region that contains a proline-rich motif, amino terminal of the SH3 domain.	Proline	131-138	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	92-97
7969135-3	1994	The carboxyl-terminal domains of Cln2 and the other G1 cyclins contain sequences rich in Pro, Glu (and Asp), Ser, and Thr (so-called PEST motifs) that have been postulated to make up the signals that are responsible for the rapid degradation of these and other unstable proteins.	Proline	89-92	cyclin CLN2	Saccharomyces cerevisiae S288C	33-37
7999109-0	1994	Iminodipeptides containing proline with C-terminal and N-terminal residues prime the stimulation of human neutrophil superoxide generation by fMLP.	Proline	27-34	formyl peptide receptor 1	Homo sapiens	142-146
7773778-4	1994	The orientation of the bound peptide is opposite to that of proline-rich peptides bound to the SH3 domains of Abl, Fyn and p85.	Proline	60-67	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	110-113
7773778-4	1994	The orientation of the bound peptide is opposite to that of proline-rich peptides bound to the SH3 domains of Abl, Fyn and p85.	Proline	60-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	115-118
7773778-4	1994	The orientation of the bound peptide is opposite to that of proline-rich peptides bound to the SH3 domains of Abl, Fyn and p85.	Proline	60-67	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	123-126
7773779-0	1994	NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos.	Proline	74-81	growth factor receptor bound protein 2	Homo sapiens	46-50
7773779-0	1994	NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos.	Proline	74-81	xylosyltransferase 2	Homo sapiens	100-103
7773779-2	1994	GRB2 couples receptor tyrosine kinase activation to Ras signalling by interacting, through its SH3 domains, to the carboxy-terminal proline-rich regions of the guanine nucleotide exchange factor Sos.	Proline	132-139	growth factor receptor bound protein 2	Homo sapiens	0-4
7773779-2	1994	GRB2 couples receptor tyrosine kinase activation to Ras signalling by interacting, through its SH3 domains, to the carboxy-terminal proline-rich regions of the guanine nucleotide exchange factor Sos.	Proline	132-139	xylosyltransferase 2	Homo sapiens	195-198
7773779-4	1994	1H NMR analysis of the complex between the Ser-32-GRB2-N-SH3 domain and the proline-rich peptide VPPPVPPRRR, derived from h-Sos, shows that relative to the SH3 peptide complexes described for PI3K, Fyn and Abl, the proline-rich peptide in this complex binds in the opposite orientation.	Proline	76-83	growth factor receptor bound protein 2	Homo sapiens	50-54
7773779-4	1994	1H NMR analysis of the complex between the Ser-32-GRB2-N-SH3 domain and the proline-rich peptide VPPPVPPRRR, derived from h-Sos, shows that relative to the SH3 peptide complexes described for PI3K, Fyn and Abl, the proline-rich peptide in this complex binds in the opposite orientation.	Proline	215-222	growth factor receptor bound protein 2	Homo sapiens	50-54
7975251-7	1994	Our results showed that replacement of one or two prolines did not stop gag VLP formation, whereas replacement of all three prolines by leucine residues completely abolished VLP assembly.	Proline	124-132	VHL like	Homo sapiens	174-177
7959018-1	1994	The human cDNA encoding prolyl endopeptidase, a cytoplasmic endoprotease which hydrolyses the peptide bond at the C-terminal side of proline, was sequenced.	Proline	133-140	prolyl endopeptidase	Homo sapiens	24-44
7969494-4	1994	A proline-rich region conserved in all HIV-1 Gag polyproteins is required for cyclophilin A binding and incorporation.	Proline	2-9	Pr55(Gag)	Human immunodeficiency virus 1	45-48
7969494-5	1994	Disruption of a single proline blocks the Gag-cyclophilin interaction in vitro, prevents cyclophilin A incorporation into virions, and inhibits HIV-1 replication.	Proline	23-30	Pr55(Gag)	Human immunodeficiency virus 1	42-45
7972090-5	1994	In contrast, a proline-substituted mutant of AKAP peptide has no effect.	Proline	15-22	A-kinase anchoring protein 1	Homo sapiens	45-49
7800495-0	1994	CD and DNA binding studies of a proline repeat-containing segment of the replication arrest protein Tus.	Proline	32-39	DNA replication terminus site-binding protein	Escherichia coli	100-103
7802869-1	1994	The Src-homology-3 (SH3) domains of the Caenorhabditis elegans protein SEM-5 and its human and Drosophila homologues, Grb2 and Drk (refs 1-4), bind proline-rich sequences found in the nucleotide-exchange factor Sos as part of their proposed function linking receptor tyrosine kinase activation to Ras activation.	Proline	148-155	Sex muscle abnormal protein 5	Caenorhabditis elegans	71-76
7802869-1	1994	The Src-homology-3 (SH3) domains of the Caenorhabditis elegans protein SEM-5 and its human and Drosophila homologues, Grb2 and Drk (refs 1-4), bind proline-rich sequences found in the nucleotide-exchange factor Sos as part of their proposed function linking receptor tyrosine kinase activation to Ras activation.	Proline	148-155	downstream of receptor kinase	Drosophila melanogaster	118-122
7802869-1	1994	The Src-homology-3 (SH3) domains of the Caenorhabditis elegans protein SEM-5 and its human and Drosophila homologues, Grb2 and Drk (refs 1-4), bind proline-rich sequences found in the nucleotide-exchange factor Sos as part of their proposed function linking receptor tyrosine kinase activation to Ras activation.	Proline	148-155	downstream of receptor kinase	Drosophila melanogaster	127-130
7961823-8	1994	A portion of apo(a) was also bound to the cell surface via its kringle domains and could be released into the medium by 6-amino hexanoic acid or proline.	Proline	145-152	apolipoprotein(a)	Papio anubis	13-19
7961857-1	1994	The influence of proline on bending of the alpha-helix was investigated by replacement of the proline residue located in the middle of the long alpha-helix of the Fis protein with alanine, serine, or leucine.	Proline	94-101	long intergenic non-protein coding RNA 1554	Homo sapiens	163-166
7961857-5	1994	One of the alpha-helices, the B-helix, is kinked in the wild-type Fis protein by 20 degrees which was previously assumed to be caused solely by the presence of proline 61 in the center of the helix.	Proline	160-167	long intergenic non-protein coding RNA 1554	Homo sapiens	66-69
7957246-5	1994	Rat IGF-II purified from the rat BRL 3A cell line is a mixture of two molecules beginning with Ala-Tyr-Arg-Pro-Ser- and Tyr-Arg-Pro-Ser- [Marquardt, H., Todaro, G. J., Henderson, L. E. &amp; Oroszlan, S. (1981) J. Biol.	Proline	107-110	insulin-like growth factor 2	Rattus norvegicus	4-10
7698752-4	1994	Partial sequencing of NRAMP confirmed the presence of the N-terminal proline/serine-rich putative SH3 binding domain in exon 2 of the human gene.	Proline	69-76	solute carrier family 11 member 1	Homo sapiens	22-27
7957246-5	1994	Rat IGF-II purified from the rat BRL 3A cell line is a mixture of two molecules beginning with Ala-Tyr-Arg-Pro-Ser- and Tyr-Arg-Pro-Ser- [Marquardt, H., Todaro, G. J., Henderson, L. E. &amp; Oroszlan, S. (1981) J. Biol.	Proline	128-131	insulin-like growth factor 2	Rattus norvegicus	4-10
7957104-6	1994	In addition to the Myb-like region, the protein MybSt1 contains an acidic segment in its central region as well as a proline-rich region near the C-terminus.	Proline	117-124	MYBST1 protein	Solanum tuberosum	48-54
7957246-7	1994	256, 6859-6865] while human IGF-II begins with Ala-Tyr-Arg-Pro-Ser-.	Proline	59-62	insulin like growth factor 2	Homo sapiens	28-34
7957246-8	1994	Determination of the N-terminal amino acid sequence of human IGF-II before and after digestion with DAP-I showed that DAP-I cleaved Ala-Tyr, terminating at Arg-Pro-; the rat IGF-II species beginning with Tyr-Arg-Pro-Ser- was resistant to digestion.	Proline	160-163	insulin like growth factor 2	Homo sapiens	61-67
7957246-8	1994	Determination of the N-terminal amino acid sequence of human IGF-II before and after digestion with DAP-I showed that DAP-I cleaved Ala-Tyr, terminating at Arg-Pro-; the rat IGF-II species beginning with Tyr-Arg-Pro-Ser- was resistant to digestion.	Proline	212-215	insulin like growth factor 2	Homo sapiens	61-67
7523301-4	1994	The enzyme hydrolyzed (optimum pH 6.5) the Pro-pNA bond in carbobenzoxy-Gly-Pro-p-nitroanilide (Z-Gly-Pro-pNA) and bonds at the carboxyl side of proline in several human bioactive peptides, such as bradykinin, substance P, neurotensin, angiotensins, oxytocin, vasopressin, and human endothelin fragment 22-38.	Proline	145-152	tachykinin precursor 1	Homo sapiens	210-221
7713281-0	1994	Lack of in vitro complement activation by the human insulin analogue LYS(b28)PRO(B29)	Proline	77-80	insulin	Homo sapiens	52-59
7713281-0	1994	Lack of in vitro complement activation by the human insulin analogue LYS(b28)PRO(B29)	Proline	77-80	MIS18 kinetochore protein A	Homo sapiens	73-76
7713281-0	1994	Lack of in vitro complement activation by the human insulin analogue LYS(b28)PRO(B29)	Proline	77-80	CD79b molecule	Homo sapiens	81-84
7523301-4	1994	The enzyme hydrolyzed (optimum pH 6.5) the Pro-pNA bond in carbobenzoxy-Gly-Pro-p-nitroanilide (Z-Gly-Pro-pNA) and bonds at the carboxyl side of proline in several human bioactive peptides, such as bradykinin, substance P, neurotensin, angiotensins, oxytocin, vasopressin, and human endothelin fragment 22-38.	Proline	145-152	kininogen 1	Homo sapiens	198-208
7765605-4	1994	The enzyme hydrolyzed substrates such as Pro-Pro-Pro-Pro, Pro-Pro-Pro, and Pro-Pro to proline, and cleaved N-terminal amino acids from peptides containing penultimate prolines such as bradykinin and neuropeptide Y.	Proline	86-93	kininogen 1	Bos taurus	184-194
7765605-4	1994	The enzyme hydrolyzed substrates such as Pro-Pro-Pro-Pro, Pro-Pro-Pro, and Pro-Pro to proline, and cleaved N-terminal amino acids from peptides containing penultimate prolines such as bradykinin and neuropeptide Y.	Proline	86-93	neuropeptide Y	Bos taurus	199-213
7765605-4	1994	The enzyme hydrolyzed substrates such as Pro-Pro-Pro-Pro, Pro-Pro-Pro, and Pro-Pro to proline, and cleaved N-terminal amino acids from peptides containing penultimate prolines such as bradykinin and neuropeptide Y.	Proline	167-175	kininogen 1	Bos taurus	184-194
7765605-4	1994	The enzyme hydrolyzed substrates such as Pro-Pro-Pro-Pro, Pro-Pro-Pro, and Pro-Pro to proline, and cleaved N-terminal amino acids from peptides containing penultimate prolines such as bradykinin and neuropeptide Y.	Proline	167-175	neuropeptide Y	Bos taurus	199-213
7956946-8	1994	Mutational analysis of the hGHR cytoplasmic domain component of the fusions indicated that a membrane-proximal 20-residue region that includes the proline-rich box 1 was necessary for the interaction.	Proline	147-154	growth hormone receptor	Homo sapiens	27-31
7523301-4	1994	The enzyme hydrolyzed (optimum pH 6.5) the Pro-pNA bond in carbobenzoxy-Gly-Pro-p-nitroanilide (Z-Gly-Pro-pNA) and bonds at the carboxyl side of proline in several human bioactive peptides, such as bradykinin, substance P, neurotensin, angiotensins, oxytocin, vasopressin, and human endothelin fragment 22-38.	Proline	145-152	neurotensin	Homo sapiens	223-234
7523301-4	1994	The enzyme hydrolyzed (optimum pH 6.5) the Pro-pNA bond in carbobenzoxy-Gly-Pro-p-nitroanilide (Z-Gly-Pro-pNA) and bonds at the carboxyl side of proline in several human bioactive peptides, such as bradykinin, substance P, neurotensin, angiotensins, oxytocin, vasopressin, and human endothelin fragment 22-38.	Proline	145-152	arginine vasopressin	Homo sapiens	260-271
7959695-4	1994	a C->T transition at position 1187 predicting leucine at residue 396 in the enzyme; proline is invariably present in evolutionary distant G6PD molecules at this position.	Proline	84-91	glucose-6-phosphate dehydrogenase	Homo sapiens	138-142
7935419-5	1994	The mutant bsd2-1 allele was isolated and found to contain a single C-to-T transition changing a centrally located proline to a serine.	Proline	115-122	Bsd2p	Saccharomyces cerevisiae S288C	11-15
24226385-2	1994	The electrospray ionization mass spectra of histidine-containing human angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) in the presence of zinc show abundant multiply charged ions for the zinc-attached peptide [M + aZn(2+) +(c - 2a)H(+)](c+), where a = 1, 2 and c is charge.	Proline	111-114	angiotensinogen	Homo sapiens	71-85
24226385-2	1994	The electrospray ionization mass spectra of histidine-containing human angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) in the presence of zinc show abundant multiply charged ions for the zinc-attached peptide [M + aZn(2+) +(c - 2a)H(+)](c+), where a = 1, 2 and c is charge.	Proline	111-114	angiotensinogen	Homo sapiens	71-84
7965454-8	1994	In contrast, the C-terminal half, containing 16 proline-rich repeats of 11 amino acid residues, is unique to BSSL.	Proline	48-55	carboxyl ester lipase	Homo sapiens	109-113
7935454-7	1994	The membrane-proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha, which is conserved among the alpha chains of IL-5R, IL-3R, and GM-CSF receptor (GM-CSFR), was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos, and c-myc, and tyrosine phosphorylation of cellular proteins including JAK2 protein-tyrosine kinase.	Proline	22-29	interleukin 5 receptor, alpha	Mus musculus	73-84
7935454-7	1994	The membrane-proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha, which is conserved among the alpha chains of IL-5R, IL-3R, and GM-CSF receptor (GM-CSFR), was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos, and c-myc, and tyrosine phosphorylation of cellular proteins including JAK2 protein-tyrosine kinase.	Proline	22-29	interleukin 5 receptor, alpha	Mus musculus	73-78
7935454-7	1994	The membrane-proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha, which is conserved among the alpha chains of IL-5R, IL-3R, and GM-CSF receptor (GM-CSFR), was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos, and c-myc, and tyrosine phosphorylation of cellular proteins including JAK2 protein-tyrosine kinase.	Proline	22-29	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	Mus musculus	138-143
7935454-7	1994	The membrane-proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha, which is conserved among the alpha chains of IL-5R, IL-3R, and GM-CSF receptor (GM-CSFR), was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos, and c-myc, and tyrosine phosphorylation of cellular proteins including JAK2 protein-tyrosine kinase.	Proline	22-29	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	Mus musculus	149-164
7935454-7	1994	The membrane-proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha, which is conserved among the alpha chains of IL-5R, IL-3R, and GM-CSF receptor (GM-CSFR), was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos, and c-myc, and tyrosine phosphorylation of cellular proteins including JAK2 protein-tyrosine kinase.	Proline	22-29	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	Mus musculus	166-173
7935454-7	1994	The membrane-proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha, which is conserved among the alpha chains of IL-5R, IL-3R, and GM-CSF receptor (GM-CSFR), was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos, and c-myc, and tyrosine phosphorylation of cellular proteins including JAK2 protein-tyrosine kinase.	Proline	22-29	interleukin 5	Mus musculus	73-77
7935454-7	1994	The membrane-proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha, which is conserved among the alpha chains of IL-5R, IL-3R, and GM-CSF receptor (GM-CSFR), was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos, and c-myc, and tyrosine phosphorylation of cellular proteins including JAK2 protein-tyrosine kinase.	Proline	22-29	jun proto-oncogene	Mus musculus	293-298
7935454-7	1994	The membrane-proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha, which is conserved among the alpha chains of IL-5R, IL-3R, and GM-CSF receptor (GM-CSFR), was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos, and c-myc, and tyrosine phosphorylation of cellular proteins including JAK2 protein-tyrosine kinase.	Proline	22-29	FBJ osteosarcoma oncogene	Mus musculus	300-305
7935454-7	1994	The membrane-proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha, which is conserved among the alpha chains of IL-5R, IL-3R, and GM-CSF receptor (GM-CSFR), was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos, and c-myc, and tyrosine phosphorylation of cellular proteins including JAK2 protein-tyrosine kinase.	Proline	22-29	Janus kinase 2	Mus musculus	378-382
7823029-2	1994	For aspartate, the unbalanced position of its amino group between a pair of carboxylates allows its occasional biorecognition as a beta-rather than as an alpha-amino acid, whereas for proline and its homologs, their cyclic arrangement may allow the imino group, without its being replicated, to be sensed analogously as falling at either of two distances from the single carboxylate group.	Proline	184-191	amyloid beta precursor protein	Homo sapiens	129-135
7918467-10	1994	Because apoD contains two intramolecular disulfide linkages and has a high content of proline to disrupt alpha-helical structures, formation of the amphipathic helical regions that characterize the other soluble apolipoproteins is unlikely.	Proline	86-93	apolipoprotein D	Homo sapiens	8-12
7524097-2	1994	ard-1 encodes a highly basic 13.3-kDa proline-rich peptide that has features in common with Rne and also with eukaryotic proteins implicated in RNA binding and macromolecular transport.	Proline	38-45	protein phosphatase 1 regulatory subunit 8	Homo sapiens	0-5
7938008-3	1994	We show here that the SH3 domains of p47-phox bind to proline-rich sequences in p47-phox itself and the p22-phox subunit of cytochrome b558.	Proline	54-61	neutrophil cytosolic factor 1	Homo sapiens	37-45
7938008-3	1994	We show here that the SH3 domains of p47-phox bind to proline-rich sequences in p47-phox itself and the p22-phox subunit of cytochrome b558.	Proline	54-61	pleckstrin	Homo sapiens	37-40
7938008-3	1994	We show here that the SH3 domains of p47-phox bind to proline-rich sequences in p47-phox itself and the p22-phox subunit of cytochrome b558.	Proline	54-61	cytochrome b-245 alpha chain	Homo sapiens	104-112
7938008-4	1994	Binding of the p47-phox SH3 domains to p22-phox was abolished by a mutation in one proline-rich sequence (Pro156--&gt;Gln) noted in a distinct form of chronic granulomatous disease and was inhibited by a short proline-rich synthetic peptide corresponding to residues 149-162 of p22-phox.	Proline	83-90	pleckstrin	Homo sapiens	15-18
7938008-4	1994	Binding of the p47-phox SH3 domains to p22-phox was abolished by a mutation in one proline-rich sequence (Pro156--&gt;Gln) noted in a distinct form of chronic granulomatous disease and was inhibited by a short proline-rich synthetic peptide corresponding to residues 149-162 of p22-phox.	Proline	83-90	calcineurin like EF-hand protein 1	Homo sapiens	39-42
7938008-4	1994	Binding of the p47-phox SH3 domains to p22-phox was abolished by a mutation in one proline-rich sequence (Pro156--&gt;Gln) noted in a distinct form of chronic granulomatous disease and was inhibited by a short proline-rich synthetic peptide corresponding to residues 149-162 of p22-phox.	Proline	83-90	calcineurin like EF-hand protein 1	Homo sapiens	278-281
7938008-4	1994	Binding of the p47-phox SH3 domains to p22-phox was abolished by a mutation in one proline-rich sequence (Pro156--&gt;Gln) noted in a distinct form of chronic granulomatous disease and was inhibited by a short proline-rich synthetic peptide corresponding to residues 149-162 of p22-phox.	Proline	210-217	pleckstrin	Homo sapiens	15-18
7938008-4	1994	Binding of the p47-phox SH3 domains to p22-phox was abolished by a mutation in one proline-rich sequence (Pro156--&gt;Gln) noted in a distinct form of chronic granulomatous disease and was inhibited by a short proline-rich synthetic peptide corresponding to residues 149-162 of p22-phox.	Proline	210-217	calcineurin like EF-hand protein 1	Homo sapiens	39-42
7938008-4	1994	Binding of the p47-phox SH3 domains to p22-phox was abolished by a mutation in one proline-rich sequence (Pro156--&gt;Gln) noted in a distinct form of chronic granulomatous disease and was inhibited by a short proline-rich synthetic peptide corresponding to residues 149-162 of p22-phox.	Proline	210-217	calcineurin like EF-hand protein 1	Homo sapiens	278-281
7535613-5	1994	The unique "kallikrein loop" insert, between Ser 95b and Pro 95k of kallikrein, was constructed using molecular mechanics, dynamics, and electrostatics calculations.	Proline	57-60	kallikrein related peptidase 4	Homo sapiens	12-22
7535613-5	1994	The unique "kallikrein loop" insert, between Ser 95b and Pro 95k of kallikrein, was constructed using molecular mechanics, dynamics, and electrostatics calculations.	Proline	57-60	kallikrein related peptidase 4	Homo sapiens	68-78
7892648-3	1994	We determined the minimum size of CCG1:CCG1ME, essential for complementing the ts mutation, which possessed one proline cluster, an HMG1-like domain, and a nuclear localization signal, but which lacked the bromo domains and the acidic phosphorylation sites for casein kinase II common to transcriptional activators.	Proline	112-119	transcription initiation factor TFIID subunit 1	Mesocricetus auratus	34-38
7918650-0	1994	Polymorphism of human transcobalamin II: substitution of proline and/or glutamine residues by arginine.	Proline	57-64	transcobalamin 2	Homo sapiens	22-39
7918650-3	1994	Nucleotide sequence analysis of TC II cDNA amplified from these cells revealed that residues Arg and Arg, Gln and Arg, and Gln and Pro were present at positions 234 and 259, respectively, in TC II alleles encoding the X, S and M types.	Proline	131-134	transcobalamin 2	Homo sapiens	32-37
7918650-3	1994	Nucleotide sequence analysis of TC II cDNA amplified from these cells revealed that residues Arg and Arg, Gln and Arg, and Gln and Pro were present at positions 234 and 259, respectively, in TC II alleles encoding the X, S and M types.	Proline	131-134	transcobalamin 2	Homo sapiens	191-196
7938008-6	1994	We also show that the cytosolic oxidase components associate with one another through the C-terminal SH3 domain of p67-phox and a proline-rich C-terminal sequence in p47-phox.	Proline	130-137	pleckstrin	Homo sapiens	166-169
7925472-3	1994	Two distinct proline-directed kinase families phosphorylate Ser25 and Ser38 of Op18 with overlapping but distinct site preference.	Proline	13-20	stathmin 1	Homo sapiens	79-83
7925286-7	1994	This binding is mediated by the SH3 domain of alpha-spectrin which binds to a unique proline-rich sequence within the C-terminal region of alpha rENaC.	Proline	85-92	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	145-150
7925286-9	1994	When microinjected into the cytoplasm of polarized primary rat alveolar epithelial cells, a recombinant fusion protein containing the C-terminal proline-rich region of alpha rENaC localized exclusively to the apical area of the plasma membrane, as determined by confocal microscopy.	Proline	145-152	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	174-179
7854037-2	1994	It has been previously described that the microtubule-associated protein, tau, modified by phosphorylation in serines adjacent to prolines, is a major component of these structures.	Proline	130-138	microtubule associated protein tau	Homo sapiens	74-77
7955057-3	1994	Only one case of hydatidiform mole was found to have a missense point mutation (codon 295, CCT--&gt;CTT, i.e. proline to leucine) of the p53 gene.	Proline	110-117	CCT	Homo sapiens	91-94
7955057-3	1994	Only one case of hydatidiform mole was found to have a missense point mutation (codon 295, CCT--&gt;CTT, i.e. proline to leucine) of the p53 gene.	Proline	110-117	tumor protein p53	Homo sapiens	137-140
7961166-3	1994	The main frame from C-1 to C-41 of these antibiotics was the same as that of amythiamicin D. Amino acid autoanalyses of amythiamicins A, B and C showed that these have another one mole of serine and proline in comparison with amythiamicin D.	Proline	199-206	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	20-23
7875941-2	1994	The folded structure induced by the N-aminoproline residue (the hydrazino analogue of proline, denoted hPro) in the Boc-Gly1-hPro2-Gly3-NHiPr hydrazino tripeptide has been characterized in the solid state by X-ray diffraction, and compared to the usual beta II-turn structure in the Boc-Gly1-Pro2-Gly36-NHiPr cognate tripeptide.	Proline	43-50	threonine aldolase 1, pseudogene	Homo sapiens	120-124
7875941-2	1994	The folded structure induced by the N-aminoproline residue (the hydrazino analogue of proline, denoted hPro) in the Boc-Gly1-hPro2-Gly3-NHiPr hydrazino tripeptide has been characterized in the solid state by X-ray diffraction, and compared to the usual beta II-turn structure in the Boc-Gly1-Pro2-Gly36-NHiPr cognate tripeptide.	Proline	43-50	threonine aldolase 1, pseudogene	Homo sapiens	287-291
8084611-5	1994	PISSLRE contained all the structural elements featured by cyclin dependent kinases, including a proline in the PSTAIRE motif, which might be important for cyclin binding.	Proline	96-103	cyclin dependent kinase 10	Homo sapiens	0-7
8083996-3	1994	In the studies reported here, we establish the location of assembly domain 2 (AD2) within the proline-rich p2b sequence of this Gag protein.	Proline	94-101	Pr76 polyprotein precursor	Rous sarcoma virus	128-131
8084611-5	1994	PISSLRE contained all the structural elements featured by cyclin dependent kinases, including a proline in the PSTAIRE motif, which might be important for cyclin binding.	Proline	96-103	proliferating cell nuclear antigen	Homo sapiens	58-64
8084611-5	1994	PISSLRE contained all the structural elements featured by cyclin dependent kinases, including a proline in the PSTAIRE motif, which might be important for cyclin binding.	Proline	96-103	proliferating cell nuclear antigen	Homo sapiens	155-161
8084614-4	1994	In addition to a previously identified SH3 domain, the predicted amino acid sequence of human eps8 revealed a non-random distribution of prolines, clustered in a way to suggest SH3-binding sites and a putative PH domain.	Proline	137-145	epidermal growth factor receptor pathway substrate 8	Homo sapiens	94-98
7929027-2	1994	The peptides possess similar proline-rich regions, which yield a consensus Src SH3-binding motif of RPLPPLP.	Proline	29-36	SRC proto-oncogene, non-receptor tyrosine kinase L homeolog	Xenopus laevis	75-78
8091672-0	1994	The protein p30, encoded at the gag-pro junction of mouse mammary tumor virus, is a dUTPase fused with a nucleocapsid protein.	Proline	4-7	centromere protein V	Homo sapiens	12-15
8091672-0	1994	The protein p30, encoded at the gag-pro junction of mouse mammary tumor virus, is a dUTPase fused with a nucleocapsid protein.	Proline	4-7	Deoxyuridine triphosphatase	Drosophila melanogaster	84-91
7929073-1	1994	A short, proline-rich region spanning residues 566-577 in human 5-lipoxygenase is a binding site for the Src homology 3 (SH3) domain of growth factor receptor-bound protein 2 (Grb2), an "adaptor" protein for tyrosine kinase-mediated cell signaling.	Proline	9-16	arachidonate 5-lipoxygenase	Homo sapiens	64-78
7925973-0	1994	Molecular cloning of Bac7, a proline- and arginine-rich antimicrobial peptide from bovine neutrophils.	Proline	29-36	cathelicidin-3	Bos taurus	21-25
7929073-1	1994	A short, proline-rich region spanning residues 566-577 in human 5-lipoxygenase is a binding site for the Src homology 3 (SH3) domain of growth factor receptor-bound protein 2 (Grb2), an "adaptor" protein for tyrosine kinase-mediated cell signaling.	Proline	9-16	growth factor receptor bound protein 2	Homo sapiens	136-174
7929073-1	1994	A short, proline-rich region spanning residues 566-577 in human 5-lipoxygenase is a binding site for the Src homology 3 (SH3) domain of growth factor receptor-bound protein 2 (Grb2), an "adaptor" protein for tyrosine kinase-mediated cell signaling.	Proline	9-16	growth factor receptor bound protein 2	Homo sapiens	176-180
7929073-3	1994	A peptide corresponding to the proline-rich, SH3-binding motif inhibited formation of the 5-lipoxygenase.Grb2 complex in vitro.	Proline	31-38	arachidonate 5-lipoxygenase	Homo sapiens	90-104
7929073-3	1994	A peptide corresponding to the proline-rich, SH3-binding motif inhibited formation of the 5-lipoxygenase.Grb2 complex in vitro.	Proline	31-38	growth factor receptor bound protein 2	Homo sapiens	105-109
7923351-5	1994	Ceramide generated by N-SMase directs the activation of proline-directed serine/threonine protein kinase(s) and phospholipase A2.	Proline	56-63	sphingomyelin phosphodiesterase 2	Homo sapiens	22-29
7923351-5	1994	Ceramide generated by N-SMase directs the activation of proline-directed serine/threonine protein kinase(s) and phospholipase A2.	Proline	56-63	phospholipase A2 group IB	Homo sapiens	112-128
7918575-0	1994	Differential processing of human and rat E1 alpha precursors of the branched-chain alpha-keto acid dehydrogenase complex caused by an N-terminal proline in the rat sequence.	Proline	145-152	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	41-49
7918575-4	1994	Comparison of the N-terminal sequences of human and rat E1 alpha subunits shows that the serine residue at the +1 position in the human sequence is replaced by a proline residue in the rat sequence.	Proline	162-169	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	56-64
7937752-2	1994	A considerable number of environmentally induced, cancer-related p53 mutations in human tumors have been found in a highly conserved proline-rich sequence of the p53 protein encompassed by amino acid residues 147-158.	Proline	133-140	tumor protein p53	Homo sapiens	65-68
7937752-2	1994	A considerable number of environmentally induced, cancer-related p53 mutations in human tumors have been found in a highly conserved proline-rich sequence of the p53 protein encompassed by amino acid residues 147-158.	Proline	133-140	tumor protein p53	Homo sapiens	162-165
7925973-1	1994	Bac7 is a 7 kDa proline- and arginine-rich antimicrobial peptide which was purified from bovine neutrophils.	Proline	16-23	cathelicidin-3	Bos taurus	0-4
7925980-5	1994	We propose here that a CDC2-like proline-directed kinase regulates myogenin activity through its phosphorylation.	Proline	33-40	cyclin dependent kinase 1	Homo sapiens	23-27
7925980-5	1994	We propose here that a CDC2-like proline-directed kinase regulates myogenin activity through its phosphorylation.	Proline	33-40	myogenin	Homo sapiens	67-75
7937100-6	1994	NFI-X2, a spliced variant, misses 41 amino acids of the proline-rich activation domain.	Proline	56-63	Nuclear factor I	Drosophila melanogaster	0-3
7727375-6	1994	We have also found that glycosylation is less efficient when rEPO is improperly folded and that prolines at -1 and +1 relative to the O-glycosylation site enhance glycosylation.	Proline	96-104	erythropoietin	Rattus norvegicus	61-65
7945191-3	1994	A minor proportion of L-proline transport is carried out by the ASC system, which appears to be constitutively expressed by the cell, but most is by system A which shows adaptive responses to amino acid deprivation and sensitivity to N-methyl-alpha-aminoisobutyric acid.	Proline	22-31	PYD and CARD domain containing	Homo sapiens	64-67
7856409-1	1994	The beta subunit of prolyl 4-hydroxylase, the protein-disulfide isomerase (PDJ), catalyzes the hydroxylation of proline residues of collagens and proteins with collagen-like structure, a step essential for the folding of the procollagen chains to form triple-helices.	Proline	112-119	prolyl 4-hydroxylase subunit beta	Homo sapiens	46-73
8086496-4	1994	The DNA-PK catalyzed phosphorylation of synthetic peptides corresponding to Myc and RB proteins in a DNA-dependent manner, indicating that DNA-PK may recognize a second core-sequence motif Pro-Ser/Thr- in addition to the putative consensus sequences of -Ser/Thr-Gln.	Proline	189-192	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	4-10
8086496-4	1994	The DNA-PK catalyzed phosphorylation of synthetic peptides corresponding to Myc and RB proteins in a DNA-dependent manner, indicating that DNA-PK may recognize a second core-sequence motif Pro-Ser/Thr- in addition to the putative consensus sequences of -Ser/Thr-Gln.	Proline	189-192	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	76-79
8086496-4	1994	The DNA-PK catalyzed phosphorylation of synthetic peptides corresponding to Myc and RB proteins in a DNA-dependent manner, indicating that DNA-PK may recognize a second core-sequence motif Pro-Ser/Thr- in addition to the putative consensus sequences of -Ser/Thr-Gln.	Proline	189-192	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	139-145
8093038-0	1994	Characterization of the proline-rich region of mouse MAPKAP kinase 2: influence on catalytic properties and binding to the c-abl SH3 domain in vitro.	Proline	24-31	MAP kinase-activated protein kinase 2	Mus musculus	53-68
8093038-0	1994	Characterization of the proline-rich region of mouse MAPKAP kinase 2: influence on catalytic properties and binding to the c-abl SH3 domain in vitro.	Proline	24-31	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	123-128
8093038-1	1994	The primary structure of mouse MAP kinase-activated protein (MAPKAP) kinase 2 contains a proline-rich N-terminal region which might function as a src-homology 3 (SH3) domain-binding motif in vivo.	Proline	89-96	MAP kinase-activated protein kinase 2	Mus musculus	31-77
8093038-3	1994	It is demonstrated, that the proline-rich region specifically binds c-abl-SH3 domain in vitro.	Proline	29-36	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	68-73
8093038-5	1994	The data suggest that the proline-rich region of MAPKAP kinase 2 could interact with proteins containing SH3-domains also in vivo regulating its cellular localization and/or modulating its enzymatic properties.	Proline	26-33	MAP kinase-activated protein kinase 2	Mus musculus	49-64
8077204-10	1994	The results suggest that the C-terminal peptide of adrenodoxin, especially proline 108, affects the structural integrity of the iron-sulfur cluster and that electron donation from adrenodoxin to CYP11A1 and CYP11B1 is determined at least in part by different features of the cytochromes.	Proline	75-82	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	195-202
8077204-10	1994	The results suggest that the C-terminal peptide of adrenodoxin, especially proline 108, affects the structural integrity of the iron-sulfur cluster and that electron donation from adrenodoxin to CYP11A1 and CYP11B1 is determined at least in part by different features of the cytochromes.	Proline	75-82	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	207-214
7856409-1	1994	The beta subunit of prolyl 4-hydroxylase, the protein-disulfide isomerase (PDJ), catalyzes the hydroxylation of proline residues of collagens and proteins with collagen-like structure, a step essential for the folding of the procollagen chains to form triple-helices.	Proline	112-119	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	75-78
7811934-2	1994	Further analysis of this sequence here has revealed that NuMA will form a two-stranded coiled-coil structure with multiple (18) points at which the conformation is interrupted either by proline-containing segments or by discontinuities in the phasing of the heptad substructure.	Proline	186-193	nuclear mitotic apparatus protein 1	Homo sapiens	57-61
8093010-8	1994	In the absence of PI4,5P2, chicken gizzard alpha-actinin binds only to the whole p85 construct, but it binds to the proline-rich region of p85 fragments in the presence of PI4,5P2.	Proline	116-123	actinin, alpha 4	Gallus gallus	43-56
8093010-8	1994	In the absence of PI4,5P2, chicken gizzard alpha-actinin binds only to the whole p85 construct, but it binds to the proline-rich region of p85 fragments in the presence of PI4,5P2.	Proline	116-123	extracellular matrix protein 1	Mus musculus	139-142
8082777-3	1994	Introduction of the multi-copy SSB1 gene into the y7-1 mutant cells suppressed defects in the degradation of X-beta-galactosidase (X = Arg or Pro) observed in the mutant cells.	Proline	142-145	splA/ryanodine receptor domain and SOCS box containing 1	Homo sapiens	31-35
7754713-5	1994	Three other ORFs show lower but significant homology: a first one to UNP, a gene related to the tre-2 oncogene from mouse and to the gene coding for the yeast deubiquitinating enzyme DOA2; a second one to SLY41, a suppressor of the functional loss of YPT1 and a third one to the gene encoding the proline utilization activator PUT3.	Proline	297-304	ubiquitin specific peptidase 4 (proto-oncogene)	Mus musculus	69-72
7980782-3	1994	Mutation of proline to serine, to alanine, or to threonine in the well-conserved GPGR sequence in the V3 region of the envelope glycoprotein was found in all these variants.	Proline	12-19	endogenous retrovirus group K member 20	Homo sapiens	119-140
8065338-0	1994	The Oct-2 glutamine-rich and proline-rich activation domains can synergize with each other or duplicates of themselves to activate transcription.	Proline	29-36	POU class 2 homeobox 2	Homo sapiens	4-9
8065338-3	1994	Both Oct-2 mRNA promoter activation domains were delineated by truncation analysis: the N-terminal Q domain is a 66-amino-acid region rich in glutamines, and the C-terminal P domain is a 42-amino-acid region rich in prolines.	Proline	216-224	POU class 2 homeobox 2	Homo sapiens	5-10
8077916-3	1994	The optional exons encode extracellular serine-, threonine- and proline-rich regions of CD46 (designated STP-A, -B and -C) which are located proximal to the plasma membrane, and alternatively cytoplasmic tails (CYT1 or CYT2).	Proline	64-71	CD46 molecule	Homo sapiens	88-92
8065331-4	1994	Wild-type and chimeric HLF proteins also bound closely related sites identified previously for bZIP proteins of both the proline- and acidic amino acid-rich (PAR) and C/EBP subfamilies; however, E2A-HLF proteins were significantly less tolerant of certain deviations from the HLF consensus binding site.	Proline	121-128	HLF transcription factor, PAR bZIP family member	Homo sapiens	23-26
7754713-5	1994	Three other ORFs show lower but significant homology: a first one to UNP, a gene related to the tre-2 oncogene from mouse and to the gene coding for the yeast deubiquitinating enzyme DOA2; a second one to SLY41, a suppressor of the functional loss of YPT1 and a third one to the gene encoding the proline utilization activator PUT3.	Proline	297-304	E2 ubiquitin-conjugating protein UBC6	Saccharomyces cerevisiae S288C	183-187
7754713-5	1994	Three other ORFs show lower but significant homology: a first one to UNP, a gene related to the tre-2 oncogene from mouse and to the gene coding for the yeast deubiquitinating enzyme DOA2; a second one to SLY41, a suppressor of the functional loss of YPT1 and a third one to the gene encoding the proline utilization activator PUT3.	Proline	297-304	Sly41p	Saccharomyces cerevisiae S288C	205-210
8063713-5	1994	The first of these substrates, NFF-1 (Mca-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Lys-(Dnp)-Gly, where Mca is (7-methoxycoumarin-4-yl)acetyl and Dnp is 2,4-dinitrophenyl), was hydrolyzed equally well by MMP-3 and MMP-2 (kcat/Km approximately 11,000 s-1 M-1).	Proline	42-45	matrix metallopeptidase 3	Homo sapiens	199-204
8069912-6	1994	WASP encodes a 501 amino acid proline-rich protein that is likely to be a key regulator of lymphocyte and platelet function.	Proline	30-37	WASP actin nucleation promoting factor	Homo sapiens	0-4
8063815-9	1994	Taken together, these results provide strong evidence that the N-terminal quarter of the cytoplasmic domain of GHR and within this region, the proline-rich motif, is required for association of JAK2 with GHR and GH-dependent activation of JAK2, and that tyrosines in the N-terminal half of the cytoplasmic domain of the GHR are phosphorylated by JAK2.	Proline	143-150	growth hormone receptor	Cricetulus griseus	111-114
8063815-9	1994	Taken together, these results provide strong evidence that the N-terminal quarter of the cytoplasmic domain of GHR and within this region, the proline-rich motif, is required for association of JAK2 with GHR and GH-dependent activation of JAK2, and that tyrosines in the N-terminal half of the cytoplasmic domain of the GHR are phosphorylated by JAK2.	Proline	143-150	tyrosine-protein kinase JAK2	Cricetulus griseus	194-198
8063815-9	1994	Taken together, these results provide strong evidence that the N-terminal quarter of the cytoplasmic domain of GHR and within this region, the proline-rich motif, is required for association of JAK2 with GHR and GH-dependent activation of JAK2, and that tyrosines in the N-terminal half of the cytoplasmic domain of the GHR are phosphorylated by JAK2.	Proline	143-150	growth hormone receptor	Cricetulus griseus	204-207
8063815-9	1994	Taken together, these results provide strong evidence that the N-terminal quarter of the cytoplasmic domain of GHR and within this region, the proline-rich motif, is required for association of JAK2 with GHR and GH-dependent activation of JAK2, and that tyrosines in the N-terminal half of the cytoplasmic domain of the GHR are phosphorylated by JAK2.	Proline	143-150	tyrosine-protein kinase JAK2	Cricetulus griseus	239-243
8063815-9	1994	Taken together, these results provide strong evidence that the N-terminal quarter of the cytoplasmic domain of GHR and within this region, the proline-rich motif, is required for association of JAK2 with GHR and GH-dependent activation of JAK2, and that tyrosines in the N-terminal half of the cytoplasmic domain of the GHR are phosphorylated by JAK2.	Proline	143-150	growth hormone receptor	Cricetulus griseus	204-207
8063815-9	1994	Taken together, these results provide strong evidence that the N-terminal quarter of the cytoplasmic domain of GHR and within this region, the proline-rich motif, is required for association of JAK2 with GHR and GH-dependent activation of JAK2, and that tyrosines in the N-terminal half of the cytoplasmic domain of the GHR are phosphorylated by JAK2.	Proline	143-150	tyrosine-protein kinase JAK2	Cricetulus griseus	239-243
8063713-5	1994	The first of these substrates, NFF-1 (Mca-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Lys-(Dnp)-Gly, where Mca is (7-methoxycoumarin-4-yl)acetyl and Dnp is 2,4-dinitrophenyl), was hydrolyzed equally well by MMP-3 and MMP-2 (kcat/Km approximately 11,000 s-1 M-1).	Proline	42-45	matrix metallopeptidase 2	Homo sapiens	209-214
8063713-5	1994	The first of these substrates, NFF-1 (Mca-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Lys-(Dnp)-Gly, where Mca is (7-methoxycoumarin-4-yl)acetyl and Dnp is 2,4-dinitrophenyl), was hydrolyzed equally well by MMP-3 and MMP-2 (kcat/Km approximately 11,000 s-1 M-1).	Proline	50-53	matrix metallopeptidase 3	Homo sapiens	199-204
8063713-5	1994	The first of these substrates, NFF-1 (Mca-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Lys-(Dnp)-Gly, where Mca is (7-methoxycoumarin-4-yl)acetyl and Dnp is 2,4-dinitrophenyl), was hydrolyzed equally well by MMP-3 and MMP-2 (kcat/Km approximately 11,000 s-1 M-1).	Proline	50-53	matrix metallopeptidase 2	Homo sapiens	209-214
8051088-4	1994	The purified venom mucin comprised about 85% carbohydrate and 15% protein and was rich in Thr, Ser, Pro, Gly, Glu, Asp, and Ala.	Proline	100-103	LOC100508689	Homo sapiens	19-24
7519475-4	1994	When transformed and induced in Escherichia coli, the two constructs produce glutathione S-transferase (GST)/N-terminal GPIIIa fusion proteins, one containing leucine at position 33 (PlA1), the other proline (PlA2).	Proline	200-207	integrin subunit beta 3	Homo sapiens	120-126
7749367-3	1994	Both are of the general sequence D-Arg0-Arg1-Pro2-W3-Gly4-X5-Ser6-Y7-Z8+ ++-Arg9, where W is either Pro or Hyp, and X is an aromatic or aliphatic side chain-containing amino acid.	Proline	45-48	arginase 1	Homo sapiens	40-44
8074188-2	1994	When A10 cells were incubated for 4 h in medium made hypertonic by addition of sucrose, there was a marked increase in Na(+)-dependent transport of alanine and proline but no change in Na(+)-dependent Pi uptake or Na(+)-independent uptake of leucine and inositol.	Proline	160-167	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	5-8
8074188-1	1994	The A10 line of vascular smooth muscle cells has Na+ dependent transport systems for alanine, proline, and Pi, whereas uptake of leucine, myo-inositol and D-glucose is Na+ independent.	Proline	94-101	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	4-7
7920710-1	1994	Two genes, Prp1 and Prp2, encode proline-rich proteins that are found in different stages of developing seed coats, hypocotyls, and roots of soybeans (Glycine max (L.) Merr.).	Proline	33-40	repetitive proline-rich cell wall protein 1	Glycine max	11-15
8062822-7	1994	The MEP1 gene is most highly expressed when the cells are grown on low concentrations of ammonium or on "poor" nitrogen sources like urea or proline.	Proline	141-148	ammonium permease MEP1	Saccharomyces cerevisiae S288C	4-8
7812194-4	1994	ETO, also called MTG8 (myeloid translocation gene on 8) has no overall homology to known proteins, but it contains two DNA-binding zinc finger motifs and several regions that are proline- and serine-rich.	Proline	179-186	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	0-3
7812194-4	1994	ETO, also called MTG8 (myeloid translocation gene on 8) has no overall homology to known proteins, but it contains two DNA-binding zinc finger motifs and several regions that are proline- and serine-rich.	Proline	179-186	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	17-21
7812194-4	1994	ETO, also called MTG8 (myeloid translocation gene on 8) has no overall homology to known proteins, but it contains two DNA-binding zinc finger motifs and several regions that are proline- and serine-rich.	Proline	179-186	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	23-54
7664083-2	1994	We have determined high-resolution crystal structures of the complexes between the SH3 domains of Abl and Fyn tyrosine kinases, and two ten-residue proline-rich peptides derived from the SH3-binding proteins 3BP-1 and 3BP-2.	Proline	148-155	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	98-101
7664083-2	1994	We have determined high-resolution crystal structures of the complexes between the SH3 domains of Abl and Fyn tyrosine kinases, and two ten-residue proline-rich peptides derived from the SH3-binding proteins 3BP-1 and 3BP-2.	Proline	148-155	SH3 domain binding protein 1	Homo sapiens	208-223
8058286-5	1994	RESULTS: A mutation in codon 216 of the peripherin/rds gene, resulting in a substitution of the amino acid serine for proline, was found to segregate with retinitis pigmentosa in these two families.	Proline	118-125	peripherin	Homo sapiens	40-50
8058286-5	1994	RESULTS: A mutation in codon 216 of the peripherin/rds gene, resulting in a substitution of the amino acid serine for proline, was found to segregate with retinitis pigmentosa in these two families.	Proline	118-125	peripherin 2	Homo sapiens	51-54
7987221-4	1994	By guanidine hydrochloride denaturation, the protein is calculated to have a free energy of unfolding of 4.1 kcal/mol at 25 degrees C. We have also characterized binding of the domain to 2 different length proline-rich peptides from the guanine nucleotide exchange factor, Sos, one of Sem-5"s likely physiological ligands in cytoplasmic signal transduction.	Proline	206-213	Sex muscle abnormal protein 5	Caenorhabditis elegans	285-290
8045889-8	1994	In addition to the finding of specific regulation of gene expression by the end products of their respective pathways, it was found that the levels of anthranilate synthase and alpha-isopropylmalate synthase were reduced upon growth in the presence of amino acids of other families, such as L-alanine, L-proline, or L-arginine.	Proline	302-311	anthranilate synthase component I	Methanothermobacter marburgensis str. Marburg	151-172
7951320-4	1994	Sequencing of cDNA clones shows that the normal SYT gene encodes a protein rich in glutamine, proline and glycine, and indicates that in synovial sarcoma rearrangement of the SYT gene results in the formation of an SYT-SSX fusion protein.	Proline	94-101	synaptotagmin 1	Homo sapiens	48-51
8035999-7	1994	Competition assays with synthetic peptides showed the involvement of the predicted proline-rich sequence in binding between YAP65 and the Yes kinase.	Proline	83-90	Yes1 associated transcriptional regulator	Homo sapiens	124-129
7972490-2	1994	The cDNA library was made from poly(A)+ RNA from leaves challenged with mercuric chloride for 2 d. The two clones, pCh2 and pCh11, appear to encode class I chitinase isoforms with cysteine-rich domains (not found in pCh11 due to the incomplete sequence) and proline-/glycine-rich or proline-rich hinge domains, respectively.	Proline	258-265	pCh2	Zea mays	115-119
7972490-2	1994	The cDNA library was made from poly(A)+ RNA from leaves challenged with mercuric chloride for 2 d. The two clones, pCh2 and pCh11, appear to encode class I chitinase isoforms with cysteine-rich domains (not found in pCh11 due to the incomplete sequence) and proline-/glycine-rich or proline-rich hinge domains, respectively.	Proline	258-265	LOW QUALITY PROTEIN: basic endochitinase A	Zea mays	124-129
7972490-2	1994	The cDNA library was made from poly(A)+ RNA from leaves challenged with mercuric chloride for 2 d. The two clones, pCh2 and pCh11, appear to encode class I chitinase isoforms with cysteine-rich domains (not found in pCh11 due to the incomplete sequence) and proline-/glycine-rich or proline-rich hinge domains, respectively.	Proline	258-265	chitinase chem 5	Zea mays	156-165
7972490-2	1994	The cDNA library was made from poly(A)+ RNA from leaves challenged with mercuric chloride for 2 d. The two clones, pCh2 and pCh11, appear to encode class I chitinase isoforms with cysteine-rich domains (not found in pCh11 due to the incomplete sequence) and proline-/glycine-rich or proline-rich hinge domains, respectively.	Proline	283-290	pCh2	Zea mays	115-119
7972490-2	1994	The cDNA library was made from poly(A)+ RNA from leaves challenged with mercuric chloride for 2 d. The two clones, pCh2 and pCh11, appear to encode class I chitinase isoforms with cysteine-rich domains (not found in pCh11 due to the incomplete sequence) and proline-/glycine-rich or proline-rich hinge domains, respectively.	Proline	283-290	LOW QUALITY PROTEIN: basic endochitinase A	Zea mays	124-129
7972490-2	1994	The cDNA library was made from poly(A)+ RNA from leaves challenged with mercuric chloride for 2 d. The two clones, pCh2 and pCh11, appear to encode class I chitinase isoforms with cysteine-rich domains (not found in pCh11 due to the incomplete sequence) and proline-/glycine-rich or proline-rich hinge domains, respectively.	Proline	283-290	chitinase chem 5	Zea mays	156-165
7920710-1	1994	Two genes, Prp1 and Prp2, encode proline-rich proteins that are found in different stages of developing seed coats, hypocotyls, and roots of soybeans (Glycine max (L.) Merr.).	Proline	33-40	repetitive proline-rich cell wall protein 2	Glycine max	20-24
8054469-8	1994	The NOESY experiment shows two new important cross peaks for one conformation, namely Pro2 (alpha)-Pro3 (alpha) and the Pro2 (alpha)-Gly4(NH), indicating a cis Pro2-Pro3 bond and a type VI beta-turn between residues Arg1 and Gly4 involving cis proline at position 3, respectively.	Proline	244-251	pyrroline-5-carboxylate reductase 1	Homo sapiens	99-103
8054469-8	1994	The NOESY experiment shows two new important cross peaks for one conformation, namely Pro2 (alpha)-Pro3 (alpha) and the Pro2 (alpha)-Gly4(NH), indicating a cis Pro2-Pro3 bond and a type VI beta-turn between residues Arg1 and Gly4 involving cis proline at position 3, respectively.	Proline	244-251	pyrroline-5-carboxylate reductase 1	Homo sapiens	165-169
8054469-8	1994	The NOESY experiment shows two new important cross peaks for one conformation, namely Pro2 (alpha)-Pro3 (alpha) and the Pro2 (alpha)-Gly4(NH), indicating a cis Pro2-Pro3 bond and a type VI beta-turn between residues Arg1 and Gly4 involving cis proline at position 3, respectively.	Proline	244-251	arginase 1	Homo sapiens	216-220
8039498-9	1994	This complex formation was reconstituted in vitro using recombinant baculovirus-expressed IRS-1, GST-Grb2 fusion proteins and dynamin peptides containing proline-rich sequences.	Proline	154-161	dynamin-2	Cricetulus griseus	126-133
7798168-10	1994	111, 2341-2351 (1990)] have reported that Pro-11, Gly-170, and Ile-340 in normal human AGT1 were replaced by Leu, Arg, and Met, respectively, in a patient with primary hyperoxaluria type 1.	Proline	42-45	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	87-91
8021301-4	1994	After an incubation of the cells with radiolabeled proline or methionine, two major proteins were identified, p450-480 and p290 (so named because of their molecular masses).	Proline	51-58	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	110-114
7865491-1	1994	OBJECTIVES: Angiotensin converting enzyme (ACE) has been shown to be an important peptidasse that play a role in digestion and assimilation of protein rich in proline such as casein, gliadin and collagen.	Proline	159-166	angiotensin I converting enzyme	Rattus norvegicus	12-41
7865491-1	1994	OBJECTIVES: Angiotensin converting enzyme (ACE) has been shown to be an important peptidasse that play a role in digestion and assimilation of protein rich in proline such as casein, gliadin and collagen.	Proline	159-166	angiotensin I converting enzyme	Rattus norvegicus	43-46
7516469-7	1994	All of these proteins contain proline-rich peptide motifs that could serve as SH3 domain ligands, and the binding of these proteins to the Src SH3 domain was inhibited with a proline-rich Src SH3 peptide ligand.	Proline	30-37	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	139-142
7516469-7	1994	All of these proteins contain proline-rich peptide motifs that could serve as SH3 domain ligands, and the binding of these proteins to the Src SH3 domain was inhibited with a proline-rich Src SH3 peptide ligand.	Proline	30-37	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	188-191
7516469-7	1994	All of these proteins contain proline-rich peptide motifs that could serve as SH3 domain ligands, and the binding of these proteins to the Src SH3 domain was inhibited with a proline-rich Src SH3 peptide ligand.	Proline	175-182	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	139-142
7516469-7	1994	All of these proteins contain proline-rich peptide motifs that could serve as SH3 domain ligands, and the binding of these proteins to the Src SH3 domain was inhibited with a proline-rich Src SH3 peptide ligand.	Proline	175-182	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	188-191
7958544-0	1994	Pharmacokinetics, pharmacodynamics and glucose counterregulation following subcutaneous injection of the monomeric insulin analogue [Lys(B28),Pro(B29)] in IDDM.	Proline	142-145	insulin	Homo sapiens	115-122
8021240-1	1994	A cDNA coding for bovine pancreatic RNase A was mutagenized to insert a proline, a leucine, and 2 cysteine residues, i.e. the residues present at corresponding positions in the subunit of seminal RNase, the only dimeric RNase of the pancreatic-type superfamily.	Proline	72-79	ribonuclease pancreatic	Bos taurus	36-43
8207810-6	1994	This arginine- and proline-rich sequence is probably important in anchoring the first transmembrane domain in the plasma membrane, since these mutated LMP1s had altered stability and cell membrane localization.	Proline	19-26	PDZ and LIM domain 7	Homo sapiens	151-155
7812043-2	1994	Ser-1002 is followed immediately by Pro-1003, a residue that may promote the adoption of a specific conformation at this site or severe as a recognition element for the interaction of the EGF receptor with other proteins.	Proline	36-39	epidermal growth factor receptor	Homo sapiens	188-200
7812043-8	1994	The findings are consistent with the hypothesis that Pro-1003 plays a role in a form of regulation that normally suppresses EGF receptor function.	Proline	53-56	epidermal growth factor receptor	Homo sapiens	124-136
8029001-4	1994	More importantly, we find that the proline-rich transcriptional activation domain of the CCAAT-box-binding factor CTF/NF1 contains a sequence with striking similarity to the heptapeptide repeats of the CTD.	Proline	35-42	nuclear factor I X	Homo sapiens	114-121
8007964-6	1994	A proline-rich amino-terminal region (residues 1 to 206) of MNF functions as a transcriptional activation domain.	Proline	2-9	forkhead box K1	Homo sapiens	60-63
7969903-8	1994	These results are compatible with a role for the mode I phosphorylation of MAP1B (which might be catalysed by proline-directed protein kinases) in supporting a rapid axonal-specific growth mechanism and a more general role for the mode II phosphorylation of MAP1B (which seems to be catalysed by casein kinase II) in controlling axonal and dendritic growth and remodeling.	Proline	110-117	microtubule-associated protein 1B	Rattus norvegicus	75-80
7919995-2	1994	The replacement of the wild-type cytosine-253 to adenine results in the replacement of the wild-type Pro at codon 52 (CCC) with Thr (ACC) located in exon 1 of the TSHR.	Proline	101-104	thyroid stimulating hormone receptor	Homo sapiens	163-167
8029001-5	1994	We show that this CTD-like motif is essential for the transcriptional activator function of the proline-rich domain of CTF/NF1.	Proline	96-103	nuclear factor I X	Homo sapiens	119-122
8029001-5	1994	We show that this CTD-like motif is essential for the transcriptional activator function of the proline-rich domain of CTF/NF1.	Proline	96-103	neurofibromin 1	Homo sapiens	123-126
8029001-7	1994	We further show that the proline-rich activation domain of CTF/NF1 interacts directly with the TATA-box-binding protein (TBP), and that a mutation in the CTD-like motif that abolishes transcriptional activation reduces the affinity of the proline-rich domain for TBP.	Proline	25-32	nuclear factor I X	Homo sapiens	59-62
8029001-7	1994	We further show that the proline-rich activation domain of CTF/NF1 interacts directly with the TATA-box-binding protein (TBP), and that a mutation in the CTD-like motif that abolishes transcriptional activation reduces the affinity of the proline-rich domain for TBP.	Proline	25-32	neurofibromin 1	Homo sapiens	63-66
8029001-7	1994	We further show that the proline-rich activation domain of CTF/NF1 interacts directly with the TATA-box-binding protein (TBP), and that a mutation in the CTD-like motif that abolishes transcriptional activation reduces the affinity of the proline-rich domain for TBP.	Proline	25-32	TATA-box binding protein	Homo sapiens	95-119
8029001-7	1994	We further show that the proline-rich activation domain of CTF/NF1 interacts directly with the TATA-box-binding protein (TBP), and that a mutation in the CTD-like motif that abolishes transcriptional activation reduces the affinity of the proline-rich domain for TBP.	Proline	25-32	TATA-box binding protein	Homo sapiens	121-124
8029001-7	1994	We further show that the proline-rich activation domain of CTF/NF1 interacts directly with the TATA-box-binding protein (TBP), and that a mutation in the CTD-like motif that abolishes transcriptional activation reduces the affinity of the proline-rich domain for TBP.	Proline	25-32	TATA-box binding protein	Homo sapiens	263-266
8029001-7	1994	We further show that the proline-rich activation domain of CTF/NF1 interacts directly with the TATA-box-binding protein (TBP), and that a mutation in the CTD-like motif that abolishes transcriptional activation reduces the affinity of the proline-rich domain for TBP.	Proline	239-246	nuclear factor I X	Homo sapiens	59-62
8029001-7	1994	We further show that the proline-rich activation domain of CTF/NF1 interacts directly with the TATA-box-binding protein (TBP), and that a mutation in the CTD-like motif that abolishes transcriptional activation reduces the affinity of the proline-rich domain for TBP.	Proline	239-246	neurofibromin 1	Homo sapiens	63-66
8029001-7	1994	We further show that the proline-rich activation domain of CTF/NF1 interacts directly with the TATA-box-binding protein (TBP), and that a mutation in the CTD-like motif that abolishes transcriptional activation reduces the affinity of the proline-rich domain for TBP.	Proline	239-246	TATA-box binding protein	Homo sapiens	95-119
8029001-7	1994	We further show that the proline-rich activation domain of CTF/NF1 interacts directly with the TATA-box-binding protein (TBP), and that a mutation in the CTD-like motif that abolishes transcriptional activation reduces the affinity of the proline-rich domain for TBP.	Proline	239-246	TATA-box binding protein	Homo sapiens	121-124
8202490-5	1994	The unmasking of p47-SH3 appears to play a crucial role in the assembly of the oxidase components, because p47-SH3 binds to both p22phox and p67phox but fails to interact with a mutant p22phox carrying a Pro-156--&gt;Gln substitution in a proline-rich region, which has been found in a patient with chronic granulomatous disease.	Proline	204-207	calcineurin like EF-hand protein 1	Homo sapiens	129-132
8202490-5	1994	The unmasking of p47-SH3 appears to play a crucial role in the assembly of the oxidase components, because p47-SH3 binds to both p22phox and p67phox but fails to interact with a mutant p22phox carrying a Pro-156--&gt;Gln substitution in a proline-rich region, which has been found in a patient with chronic granulomatous disease.	Proline	239-246	calcineurin like EF-hand protein 1	Homo sapiens	129-132
8029001-7	1994	We further show that the proline-rich activation domain of CTF/NF1 interacts directly with the TATA-box-binding protein (TBP), and that a mutation in the CTD-like motif that abolishes transcriptional activation reduces the affinity of the proline-rich domain for TBP.	Proline	239-246	TATA-box binding protein	Homo sapiens	263-266
8002930-5	1994	The overall composition of the deduced amino acid sequence matched that expected for a mucin protein core and is rich in serine, threonine, proline, glycine and alanine (approximately 51%).	Proline	140-147	LOC100508689	Homo sapiens	87-92
8016155-8	1994	Deletion of the proline-rich region or changing the four prolines to alanines also resulted in a GH receptor deficient in signaling.	Proline	16-23	growth hormone receptor	Homo sapiens	97-108
8016155-8	1994	Deletion of the proline-rich region or changing the four prolines to alanines also resulted in a GH receptor deficient in signaling.	Proline	57-65	growth hormone receptor	Homo sapiens	97-108
8016155-10	1994	These results indicate that the intracellular part of the GH receptor can be divided into at least three functional domains: (i) for transcriptional activity, two domains are involved, one located in the C-terminal 184 amino acids and the other in the proline-rich domain; (ii) for metabolic effects, a domain located in or near the proline-rich region is of importance; and (iii) for internalization, phenylalanine 346 is necessary.	Proline	252-259	growth hormone receptor	Homo sapiens	58-69
8016155-10	1994	These results indicate that the intracellular part of the GH receptor can be divided into at least three functional domains: (i) for transcriptional activity, two domains are involved, one located in the C-terminal 184 amino acids and the other in the proline-rich domain; (ii) for metabolic effects, a domain located in or near the proline-rich region is of importance; and (iii) for internalization, phenylalanine 346 is necessary.	Proline	333-340	growth hormone receptor	Homo sapiens	58-69
7911091-0	1994	A homology-based molecular model of the proline-rich homeodomain protein Prh, from haematopoietic cells.	Proline	40-47	hematopoietically expressed homeobox	Homo sapiens	73-76
8079656-4	1994	Elevated G6PD levels in response to loading and PGI2 persisted for 18 h, by which time, ALP activity in surface osteoblasts was elevated and [3H]proline incorporation into collagen increased.	Proline	145-152	glucose-6-phosphate dehydrogenase	Rattus norvegicus	9-13
7920216-6	1994	The reciprocal genes on chromosomes 4q21, 9p22 and 19p13 have been recently cloned and are predicted to encode proline and serine rich proteins.	Proline	111-118	H3 histone pseudogene 6	Homo sapiens	53-56
8079516-9	1994	A cluster of proline residues, which is conserved at residues 36-50 in all of the published sequences of NS3 of BT viruses, is conserved exactly in the alignment of the sequence of NS3 of EHDV-2 with that of the BT viruses.	Proline	13-20	KRAS proto-oncogene, GTPase	Homo sapiens	105-108
8079516-9	1994	A cluster of proline residues, which is conserved at residues 36-50 in all of the published sequences of NS3 of BT viruses, is conserved exactly in the alignment of the sequence of NS3 of EHDV-2 with that of the BT viruses.	Proline	13-20	KRAS proto-oncogene, GTPase	Homo sapiens	181-184
8002963-4	1994	The proline-rich peptide shows high sequence similarities with drosocin, an O-glycosylated antibacterial peptide from Drosophila, and also with the N-terminal domain of diptericin, an inducible 9 kDa antibacterial peptide from members of the order Diptera, whereas the glycine-rich peptide has similarities with the glycine-rich domain of diptericin.	Proline	4-11	Diptericin A	Drosophila melanogaster	169-179
8002963-4	1994	The proline-rich peptide shows high sequence similarities with drosocin, an O-glycosylated antibacterial peptide from Drosophila, and also with the N-terminal domain of diptericin, an inducible 9 kDa antibacterial peptide from members of the order Diptera, whereas the glycine-rich peptide has similarities with the glycine-rich domain of diptericin.	Proline	4-11	Diptericin A	Drosophila melanogaster	339-349
7910950-2	1994	Transthyretin (TTR) gene analysis showed one point mutation (T--&gt;C change) in the second base of codon 55, and the corresponding amino acid substitution of proline (Pro) for leucine (Leu) was confirmed at the protein level.	Proline	159-166	transthyretin	Homo sapiens	0-13
7910950-2	1994	Transthyretin (TTR) gene analysis showed one point mutation (T--&gt;C change) in the second base of codon 55, and the corresponding amino acid substitution of proline (Pro) for leucine (Leu) was confirmed at the protein level.	Proline	159-166	transthyretin	Homo sapiens	15-18
7910950-2	1994	Transthyretin (TTR) gene analysis showed one point mutation (T--&gt;C change) in the second base of codon 55, and the corresponding amino acid substitution of proline (Pro) for leucine (Leu) was confirmed at the protein level.	Proline	168-171	transthyretin	Homo sapiens	0-13
7910950-2	1994	Transthyretin (TTR) gene analysis showed one point mutation (T--&gt;C change) in the second base of codon 55, and the corresponding amino acid substitution of proline (Pro) for leucine (Leu) was confirmed at the protein level.	Proline	168-171	transthyretin	Homo sapiens	15-18
7910567-1	1994	Incubation of hepatocytes under conditions known to increase their volume, i.e. with amino acids (glutamine, proline) or in hypo-osmotic medium, decreased carnitine palmitoyl-transferase I (CPT-I) activity.	Proline	109-116	carnitine palmitoyltransferase 1B	Homo sapiens	155-188
8088350-3	1994	The endothelin ETA receptor antagonist, BQ123 (D-Val,Leu,D-Trp,D-Asp,Pro; 10 microM), antagonized endothelin-1-induced contractions with an estimated potency (pKB approximately 6.0) which was an order of magnitude lower than reported previously for non-human isolated vascular tissues from other species (pA2 values approximately 7.0).	Proline	69-72	endothelin 1	Homo sapiens	98-110
8186251-9	1994	Bovine Hageman factor has no suitable amino-acid sequence as the substrate for the trypsin-type proteinases at the proline-rich region in difference from the human and guinea pig molecules.	Proline	115-122	coagulation factor XII	Bos taurus	7-21
8177321-1	1994	The mitogen-activated protein (MAP) kinases Erk-1 and Erk-2 are proline-directed kinases that are themselves activated through concomitant phosphorylation of tyrosine and threonine residues.	Proline	64-71	mitogen activated protein kinase 3	Rattus norvegicus	44-49
8177321-1	1994	The mitogen-activated protein (MAP) kinases Erk-1 and Erk-2 are proline-directed kinases that are themselves activated through concomitant phosphorylation of tyrosine and threonine residues.	Proline	64-71	mitogen activated protein kinase 1	Rattus norvegicus	54-59
8188650-5	1994	This protein was identified as p47phox, and the putative SH3 domain binding site was located to a carboxyl-terminal proline-rich region.	Proline	116-123	neutrophil cytosolic factor 1	Homo sapiens	31-38
8177321-2	1994	The kinase p54 (M(r) 54,000), which was first isolated from cycloheximide-treated rats, is proline-directed like Erks-1/2, and requires both Tyr and Ser/Thr phosphorylation for activity.	Proline	91-98	ETS proto-oncogene 1, transcription factor	Rattus norvegicus	11-14
8188650-6	1994	Proline-rich synthetic peptides based on this carboxyl-terminal region specifically inhibited the binding of p47phox to the carboxyl-terminal SH3 domain of p67phox, and sequential truncation defined a unique minimal sequence, which, although similar, does not match the consensus sequence defined for other SH3-binding proteins.	Proline	0-7	neutrophil cytosolic factor 1	Homo sapiens	109-116
8188650-6	1994	Proline-rich synthetic peptides based on this carboxyl-terminal region specifically inhibited the binding of p47phox to the carboxyl-terminal SH3 domain of p67phox, and sequential truncation defined a unique minimal sequence, which, although similar, does not match the consensus sequence defined for other SH3-binding proteins.	Proline	0-7	neutrophil cytosolic factor 2	Homo sapiens	156-163
8177321-2	1994	The kinase p54 (M(r) 54,000), which was first isolated from cycloheximide-treated rats, is proline-directed like Erks-1/2, and requires both Tyr and Ser/Thr phosphorylation for activity.	Proline	91-98	mitogen activated protein kinase 3	Rattus norvegicus	113-121
8183887-0	1994	Proline-rich activator CTF1 targets the TFIIB assembly step during transcriptional activation.	Proline	0-7	general transcription factor IIB	Homo sapiens	40-45
7514295-5	1994	In contrast, an SH3-specific proline-rich peptide completely abolished p120 binding to SH3.	Proline	29-36	catenin delta 1	Homo sapiens	71-75
8175783-5	1994	In the second group (Group 2), replacement with Gly, Pro, Ser, or Asp resulted in nonfunctional EF-2, but it did not affect the growth of cells co-expressing wild-type EF-2.	Proline	53-56	elongation factor 2	Saccharomyces cerevisiae S288C	96-100
8183887-2	1994	We show here that the proline-rich activation domain of CTF1 (CCAAT-box-binding transcription factor 1) selectively interacts with TFIIB but not with the TATA-binding protein (TBP), whereas previous studies have shown that the acidic activation domain of viral VP16 interacts directly with both TBP and TFIIB.	Proline	22-29	general transcription factor IIB	Homo sapiens	131-136
8183887-2	1994	We show here that the proline-rich activation domain of CTF1 (CCAAT-box-binding transcription factor 1) selectively interacts with TFIIB but not with the TATA-binding protein (TBP), whereas previous studies have shown that the acidic activation domain of viral VP16 interacts directly with both TBP and TFIIB.	Proline	22-29	host cell factor C1	Homo sapiens	261-265
8183887-2	1994	We show here that the proline-rich activation domain of CTF1 (CCAAT-box-binding transcription factor 1) selectively interacts with TFIIB but not with the TATA-binding protein (TBP), whereas previous studies have shown that the acidic activation domain of viral VP16 interacts directly with both TBP and TFIIB.	Proline	22-29	TATA-box binding protein	Homo sapiens	295-298
8183887-2	1994	We show here that the proline-rich activation domain of CTF1 (CCAAT-box-binding transcription factor 1) selectively interacts with TFIIB but not with the TATA-binding protein (TBP), whereas previous studies have shown that the acidic activation domain of viral VP16 interacts directly with both TBP and TFIIB.	Proline	22-29	general transcription factor IIB	Homo sapiens	303-308
8183887-5	1994	The results indicate that the proline-rich activation domain enhances transcription, at least in part, through direct interactions with TFIIB and, with previous observations, suggest models involving either quantitative or qualitative changes in TFIIB-TFIID-promoter interactions that lead to increased utilization of downstream initiation factors.	Proline	30-37	general transcription factor IIB	Homo sapiens	136-141
8183887-5	1994	The results indicate that the proline-rich activation domain enhances transcription, at least in part, through direct interactions with TFIIB and, with previous observations, suggest models involving either quantitative or qualitative changes in TFIIB-TFIID-promoter interactions that lead to increased utilization of downstream initiation factors.	Proline	30-37	general transcription factor IIB	Homo sapiens	246-251
8167337-0	1994	Proline at the P2 position in protein C is important for calcium-mediated regulation of protein C activation and secretion.	Proline	0-7	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	30-39
7840942-3	1994	The leader sequence of rat BNP contains three potential phosphorylation sites for proline-directed kinases that are not present in the leader sequence of ANP.	Proline	82-89	natriuretic peptide B	Rattus norvegicus	27-30
8167337-0	1994	Proline at the P2 position in protein C is important for calcium-mediated regulation of protein C activation and secretion.	Proline	0-7	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	88-97
7513015-0	1994	NH2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine-rich putative Src homology 3-binding domain.	Proline	113-120	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	96-101
8045593-9	1994	The results are discussed in relation to the possible function of the recently cloned candidate gene Nramp, which has structural identity to eukaryote transporters and an N-terminal cytoplasmic proline/serine-rich putative SH3 binding domain.	Proline	194-201	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	101-106
8179591-4	1994	Sequence analysis reveals that MAPKAP kinase 2 is a 370 amino acid protein containing a proline-rich N-terminal region and a well conserved catalytic domain.	Proline	88-95	MAPK activated protein kinase 2	Homo sapiens	31-46
7913773-5	1994	Further analysis of the father and members of other arms of the kindred revealed a different mutation (C insertion: CAT-->CCAT), resulting in a frameshift beginning at amino acid #107 (His-->Pro) and truncation of the protein at codon #119 of the mature protein.	Proline	191-194	catalase	Homo sapiens	116-119
8171010-3	1994	CTF7, which lacks the entire proline-rich region previously thought to mediate transcriptional activation by CTF proteins, enhances transcription to a greater degree than full-length CTF1, which contains the putative activation domain.	Proline	29-36	Eco1p	Saccharomyces cerevisiae S288C	0-4
7512160-3	1994	Fusion mutations were found in the proline-rich region of gp70.	Proline	35-42	embigin	Mus musculus	58-62
8170978-5	1994	The predicted amino acid composition is interesting in that approximately 45% of the PHAS-I protein is accounted for by only four amino acids--serine, threonine, proline, and glycine.	Proline	162-169	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	85-91
8161501-2	1994	The mutant peptide, called PAPA, has both proline residues from the wild-type sequence replaced with alanines.	Proline	42-49	pappalysin 1	Homo sapiens	27-31
8161501-4	1994	The behavior of PAPA in solution implicates the prolines in the conformational heterogeneity reported earlier for the wild-type peptide [Xu, R. X., Horvath, S. J., &amp; Klevit, R. E. (1991) Biochemistry 30, 3365-3371].	Proline	48-56	pappalysin 1	Homo sapiens	16-20
7512734-6	1994	Mutational analysis of C3G assigns the SH3 binding region to a 50-amino acid region containing a proline-rich sequence.	Proline	97-104	Rap guanine nucleotide exchange factor 1	Homo sapiens	23-26
8157692-5	1994	In PKC zeta, the only PKC isoform lacking phorbol ester binding, this region differs in a single residue from the consensus (proline in position 11 of the motif).	Proline	125-132	protein kinase C zeta	Homo sapiens	3-11
8157692-5	1994	In PKC zeta, the only PKC isoform lacking phorbol ester binding, this region differs in a single residue from the consensus (proline in position 11 of the motif).	Proline	125-132	protein kinase C zeta	Homo sapiens	3-6
8157692-6	1994	Restoration of this proline by site-directed mutagenesis of PKC zeta does not restore binding of either [3H]phorbol 12,13-dibutyrate or of the ultrapotent ligand [3H]bryostatin 1, suggesting that even a low affinity ligand interaction is absent.	Proline	20-27	protein kinase C zeta	Homo sapiens	60-68
8137293-7	1994	The ETO sequence is different from the portion of PEBP 2 alpha B it replaces in the AML1/ETO fusion protein, except for their common high content of proline, serine, and threonine residues.	Proline	149-156	RUNX1 translocation partner 1	Mus musculus	4-7
8143877-0	1994	The actin binding site in the tail domain of Dictyostelium myosin IC (myoC) resides within the glycine- and proline-rich sequence (tail homology region 2).	Proline	108-115	myosin IC	Homo sapiens	59-68
8143877-0	1994	The actin binding site in the tail domain of Dictyostelium myosin IC (myoC) resides within the glycine- and proline-rich sequence (tail homology region 2).	Proline	108-115	myosin IC	Homo sapiens	70-74
8143877-3	1994	Here we show, using fusion proteins containing portions of the Dictyostelium myosin IC (myoC) tail domain and F-actin sedimentation assays, that the ability of the myoC tail to bind to actin resides entirely within the glycine- and proline-rich TH.2 domain.	Proline	232-239	myosin IC	Homo sapiens	77-86
8143877-3	1994	Here we show, using fusion proteins containing portions of the Dictyostelium myosin IC (myoC) tail domain and F-actin sedimentation assays, that the ability of the myoC tail to bind to actin resides entirely within the glycine- and proline-rich TH.2 domain.	Proline	232-239	myosin IC	Homo sapiens	164-168
8070538-4	1994	Collagen synthesis, assessed by the [3H]proline incorporation method, was significantly increased in the right ventricle of 3-month-old Tsk mice.	Proline	40-47	fibrillin 1	Mus musculus	136-139
8177211-8	1994	The predicted RSI-1 protein is rich in cysteine, lysine and proline, and includes an N-terminal region with characteristics of a signal peptide.	Proline	60-67	protein RSI-1	Solanum lycopersicum	14-19
8144002-9	1994	Threonine, serine, and proline were the major amino acids within the esophageal mucin, whereas galactose was the predominant carbohydrate.	Proline	23-30	LOC100508689	Homo sapiens	80-85
8144592-6	1994	The HBP-1a isoforms are characterized by their N-terminal proline-rich domain and a C-terminal bZIP domain, which binds to the CCACGT motif.	Proline	58-65	transcription factor HBP-1a	Triticum aestivum	4-10
7510785-0	1994	Protein kinase FA/glycogen synthase kinase-3 predominantly phosphorylates the in vivo site Thr97-Pro in brain myelin basic protein: evidence for Thr-Pro and Ser-Arg-X-X-Ser as consensus sequence motifs.	Proline	0-3	myelin basic protein	Bos taurus	110-130
7656049-0	1994	Critical residues in an SH3 domain from Sem-5 suggest a mechanism for proline-rich peptide recognition.	Proline	70-77	Sex muscle abnormal protein 5	Caenorhabditis elegans	40-45
8132637-6	1994	These results indicate that the synthesis of glutamyl-prolyl-tRNA synthetase is regulated at a post-transcriptional step and that the synthesis of this bifunctional protein may be linked to the utilization of proline and glutamic acid in protein synthesis.	Proline	209-216	glutamyl-prolyl-tRNA synthetase	Rattus norvegicus	45-76
7510700-3	1994	In vitro studies using different bacterially synthesized GST-Sos fusion proteins confirm the formation of complexes containing p36 and the proline-rich COOH-terminal domain of Sos.	Proline	139-146	xylosyltransferase 2	Homo sapiens	61-64
7510700-3	1994	In vitro studies using different bacterially synthesized GST-Sos fusion proteins confirm the formation of complexes containing p36 and the proline-rich COOH-terminal domain of Sos.	Proline	139-146	annexin A2	Homo sapiens	127-130
7510700-3	1994	In vitro studies using different bacterially synthesized GST-Sos fusion proteins confirm the formation of complexes containing p36 and the proline-rich COOH-terminal domain of Sos.	Proline	139-146	xylosyltransferase 2	Homo sapiens	176-179
8128248-2	1994	Here it was found that the Src homology 3 (SH3) domain of Lyn and Fyn bound to a proline-rich region (residues 84 to 99) within the 85-kilodalton subunit (p85) of PI-3 kinase.	Proline	81-88	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	58-61
8142362-5	1994	However, the half-life of each purified PAI-1 mutant was extended compared to the 1.1 h observed for wild-type PAI-1 (wtPAI-1) (1.2 h for Glu-350--&gt;Arg, 2.0 h for Glu-350--&gt;Pro, and 2.1 h for the Arg-30--&gt;Glu mutation).	Proline	179-182	serpin family E member 1	Homo sapiens	40-45
8016412-2	1994	Prolonged intravenous administration of motilin (50 pmol/kg/min) significantly inhibited (P &lt; 0.05) proline transport across the jejunum and reduced basal acid secretion to 40% of control value.	Proline	103-110	motilin	Rattus norvegicus	40-47
8016412-4	1994	Incubation of intestinal strips with different concentrations of motilin produced a dose-dependent inhibitory pattern of proline accumulation in the intestinal cells.	Proline	121-128	motilin	Rattus norvegicus	65-72
8136381-8	1994	The expression of rat cholesterol esterase with zero or one proline-rich units resulted in a truncated protein that was secreted by the transfected COS cells.	Proline	60-67	carboxyl ester lipase	Rattus norvegicus	22-42
8136381-10	1994	The cholesterol esterase with fewer proline-rich repeating units were more active than the native enzyme in substrate hydrolysis at low bile salt concentrations.	Proline	36-43	carboxyl ester lipase	Rattus norvegicus	4-24
8128248-2	1994	Here it was found that the Src homology 3 (SH3) domain of Lyn and Fyn bound to a proline-rich region (residues 84 to 99) within the 85-kilodalton subunit (p85) of PI-3 kinase.	Proline	81-88	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	66-69
8128248-2	1994	Here it was found that the Src homology 3 (SH3) domain of Lyn and Fyn bound to a proline-rich region (residues 84 to 99) within the 85-kilodalton subunit (p85) of PI-3 kinase.	Proline	81-88	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	155-158
8038719-5	1994	Cloning and sequencing of this p12 gag homologue has revealed a high (63% to 89%) amino acid derived sequence identity with other retroviruses and shown that the major differences among p12 of pathogenic viral strains compared to non-pathogenic ones consist of a four amino acids deletion and a high abundance of proline and basic amino acids in their p12 region.	Proline	313-320	polymerase (DNA-directed), delta 4	Mus musculus	31-34
7926762-3	1994	To explain these results, we propose the WT1 transcript undergoes RNA editing in which U839 is converted to C, resulting in the replacement of leucine 280 in WT1 by proline.	Proline	165-172	WT1 transcription factor	Rattus norvegicus	41-44
7926762-3	1994	To explain these results, we propose the WT1 transcript undergoes RNA editing in which U839 is converted to C, resulting in the replacement of leucine 280 in WT1 by proline.	Proline	165-172	WT1 transcription factor	Rattus norvegicus	158-161
7926762-5	1994	In functional assays, the WT1-leucine280 polypeptide repressed the EGR-1 promoter in in vitro assays approximately 30% more efficiently than WT1-proline.	Proline	145-152	WT1 transcription factor	Rattus norvegicus	141-144
8125332-3	1994	These Thr-Pro-rich repeats resemble the ones in the human MUC2 gene encoding mucin.	Proline	10-13	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	58-62
8125332-3	1994	These Thr-Pro-rich repeats resemble the ones in the human MUC2 gene encoding mucin.	Proline	10-13	LOC100508689	Homo sapiens	77-82
7510218-1	1994	A common RXL motif was found in proline-rich ligands that were selected from a biased combinatorial peptide library on the basis of their ability to bind specifically to the SH3 domains from phosphatidylinositol 3-kinase (PI3K) or c-Src.	Proline	32-39	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	231-236
8129042-4	1994	Moreover, MAPKs phosphorylate tau in vitro at Ser/Thr Proline sites, generating a multiply phosphorylated tau protein that is similar to the hyperphosphorylated tau found in Alzheimer neurofibrillary tangles (NFTs).	Proline	54-61	microtubule associated protein tau	Homo sapiens	30-33
8129042-4	1994	Moreover, MAPKs phosphorylate tau in vitro at Ser/Thr Proline sites, generating a multiply phosphorylated tau protein that is similar to the hyperphosphorylated tau found in Alzheimer neurofibrillary tangles (NFTs).	Proline	54-61	microtubule associated protein tau	Homo sapiens	106-109
8129042-4	1994	Moreover, MAPKs phosphorylate tau in vitro at Ser/Thr Proline sites, generating a multiply phosphorylated tau protein that is similar to the hyperphosphorylated tau found in Alzheimer neurofibrillary tangles (NFTs).	Proline	54-61	microtubule associated protein tau	Homo sapiens	106-109
8038719-5	1994	Cloning and sequencing of this p12 gag homologue has revealed a high (63% to 89%) amino acid derived sequence identity with other retroviruses and shown that the major differences among p12 of pathogenic viral strains compared to non-pathogenic ones consist of a four amino acids deletion and a high abundance of proline and basic amino acids in their p12 region.	Proline	313-320	melanoma antigen	Mus musculus	35-38
8125121-6	1994	A leucine-zipper motif (L-X6-L-X6-L-X6-L) which was found in the auto-modification domain of Drosophila PARP, is disrupted in the Sarcophaga enzyme: the second leucine is replaced by proline, and the third leucine by valine.	Proline	183-190	Poly-(ADP-ribose) polymerase	Drosophila melanogaster	104-108
8314011-0	1994	[Lys(B28), Pro(B29)]-human insulin.	Proline	11-14	insulin	Homo sapiens	27-34
8314011-2	1994	[Lys(B28, Pro(B29)]-human insulin (LYSPRO) is an insulin analogue in which the natural amino acid sequence of the B-chain at positions 28 and 29 is inverted.	Proline	10-13	insulin	Homo sapiens	26-33
8314011-2	1994	[Lys(B28, Pro(B29)]-human insulin (LYSPRO) is an insulin analogue in which the natural amino acid sequence of the B-chain at positions 28 and 29 is inverted.	Proline	10-13	insulin	Homo sapiens	49-56
8108137-4	1994	Nucleotide sequence analysis of a full-length PTK1 cDNA showed it to encode an 847-amino acid polypeptide with an amino-terminal SH3 domain, a kinase catalytic domain, a leucine zipper-like domain, and a carboxyl proline-rich domain.	Proline	213-220	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	46-50
7912130-3	1994	Sequence analysis of these cDNA clones revealed that the transcribed gene, designated ZFM1, encodes a novel 623-amino-acid protein containing domains with interesting structural properties including a nuclear transport domain, a metal binding motif, and glutamine- and proline-rich regions.	Proline	269-276	splicing factor 1	Homo sapiens	86-90
8012352-3	1994	Mouse merlin is a 596 amino acid protein, 98% identical to human merlin, but one amino acid longer due to the insertion of a proline residue near the C-terminus.	Proline	125-132	neurofibromin 2	Mus musculus	6-12
8006073-3	1994	Here we demonstrate that calreticulin can be co-localized by immunofluorescence as well as co-purified with integrins, that recombinant calreticulin can also interact with integrins, and that the interaction occurs predominantly via the N-domain of calreticulin, to a much lesser extent with the C-domain, but not at all with the proline-rich P-domain.	Proline	330-337	calreticulin	Homo sapiens	25-37
8006073-3	1994	Here we demonstrate that calreticulin can be co-localized by immunofluorescence as well as co-purified with integrins, that recombinant calreticulin can also interact with integrins, and that the interaction occurs predominantly via the N-domain of calreticulin, to a much lesser extent with the C-domain, but not at all with the proline-rich P-domain.	Proline	330-337	calreticulin	Homo sapiens	136-148
8006073-3	1994	Here we demonstrate that calreticulin can be co-localized by immunofluorescence as well as co-purified with integrins, that recombinant calreticulin can also interact with integrins, and that the interaction occurs predominantly via the N-domain of calreticulin, to a much lesser extent with the C-domain, but not at all with the proline-rich P-domain.	Proline	330-337	calreticulin	Homo sapiens	136-148
8114711-2	1994	MZF1 contains 13 C2H2 zinc fingers arranged in two domains which are separated by a short glycine- and proline-rich sequence.	Proline	103-110	myeloid zinc finger 1	Homo sapiens	0-4
8208364-5	1994	The cytoplasmic region of frog synaptophysin is also rich in glutamine and glycine residues, but the putative consensus repeating sequence Tyr-Gly-Pro/Gln-Gln-Gly in mammalian synaptophysins does not occur in the frog protein.	Proline	147-150	synaptophysin	Homo sapiens	31-44
8112467-0	1994	HCE, a constituent of the hatching enzymes of Oryzias latipes embryos, releases unique proline-rich polypeptides from its natural substrate, the hardened chorion.	Proline	87-94	high choriolytic enzyme 1	Oryzias latipes	0-3
7998343-5	1994	D-ornithine side chain prolongation by means of the attachment of some amino acid residues (methionine, leucine, proline, asparagine) led to the original branched enkephalin analogs.	Proline	113-120	proenkephalin	Rattus norvegicus	163-173
8119925-4	1994	Synthesis of the wild type SP-A in insect cells resulted in a form of the protein in which proline residues were not hydroxylated and that is denoted SP-Ahyp.	Proline	91-98	surfactant protein A1	Homo sapiens	27-31
8112467-1	1994	HCE, a constituent protease of the hatching enzymes of Oryzias latipes embryos [1,2], releases unique proline-rich polypeptides from its natural substrate, the hardened chorion.	Proline	102-109	high choriolytic enzyme 1	Oryzias latipes	0-3
8112467-4	1994	These findings suggest that HCE recognizes specific site(s) of the chorion, releases the proline-rich polypeptides from it, and makes the substrate accessible to LCE, another protease of the hatching enzymes.	Proline	89-96	high choriolytic enzyme 1	Oryzias latipes	28-31
8107115-1	1994	The structure of mouse submaxillary renin complexed with a decapeptide inhibitor, CH-66 (Piv-His-Pro-Phe-His-Leu-OH-Leu-Tyr-Tyr-Ser-NH2), where Piv denotes a pivaloyl blocking group, and -OH- denotes a hydroxyethylene (-(S)CHOH-CH2-) transition state isostere as a scissile bond surrogate, has been refined to an agreement factor of 0.18 at 2.0 A resolution.	Proline	97-100	renin	Homo sapiens	36-41
7907418-0	1994	A proline-rich transcriptional activation domain in murine HOXD-4 (HOX-4.2).	Proline	2-9	homeobox D4	Mus musculus	59-65
8107115-9	1994	The triple proline loop (residues 292 to 294), which is structurally opposite the active-site "flap" (residues 72 to 83), gives renin a superficial resemblance to the fold of the retroviral proteinases.	Proline	11-18	renin	Homo sapiens	128-133
7907418-0	1994	A proline-rich transcriptional activation domain in murine HOXD-4 (HOX-4.2).	Proline	2-9	homeobox D4	Mus musculus	67-74
8308015-9	1994	Comparison of the tryptic phosphopeptide patterns of wild-type ER and these mutant ERs allowed us to identify serine 104 and/or serine 106 and serine 118, all three being part of a serine-proline motif, the preferred substrate of proline-directed protein kinase, as major ER phosphorylation sites.	Proline	188-195	estrogen receptor 1	Homo sapiens	83-85
7907418-5	1994	Fusions to the GAL4 DNA-binding domain mapped a transcriptional activation function to the HOXD-4 proline-rich N-terminus.	Proline	98-105	lectin, galactose binding, soluble 4	Mus musculus	15-19
7907418-5	1994	Fusions to the GAL4 DNA-binding domain mapped a transcriptional activation function to the HOXD-4 proline-rich N-terminus.	Proline	98-105	homeobox D4	Mus musculus	91-97
7907418-7	1994	Together, these results suggest that HOXD-4 harbors a transcriptional activation domain of the proline-rich type.	Proline	95-102	homeobox D4	Mus musculus	37-43
8313909-4	1994	Proline-rich domains, as e.g. in AP-2 and CTF/NF1, with considerable promoter activity and low enhancer activity in mammalian cells stimulate transcription in yeast only from a position close to the TATA box.	Proline	0-7	nuclear factor I C	Homo sapiens	42-45
8313909-4	1994	Proline-rich domains, as e.g. in AP-2 and CTF/NF1, with considerable promoter activity and low enhancer activity in mammalian cells stimulate transcription in yeast only from a position close to the TATA box.	Proline	0-7	neurofibromin 1	Homo sapiens	46-49
8155602-2	1994	Both sequences were consistent with previously reported motifs of HLA-B*3501 binding peptides which carry proline at position 2 and tyrosine at position 9 as anchor residues.	Proline	106-113	major histocompatibility complex, class I, B	Homo sapiens	66-71
8155602-7	1994	These results indicate that two anchor residues, proline at position 2 and tyrosine at position 9 are critical in binding of peptides to HLA-B*3501 molecules.	Proline	49-56	major histocompatibility complex, class I, B	Homo sapiens	137-142
7906278-5	1994	Proline also enhanced EGF-induced DNA synthesis, although it was less effective than glutamic acid.	Proline	0-7	epidermal growth factor like 1	Rattus norvegicus	22-25
8206647-3	1994	Epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) added singly caused significant increases relative to control in both the uptake of [3H]thymidine into the cellular DNA of subconfluent monolayers and of [3H]proline into collagenase-sensitive protein.	Proline	230-237	epidermal growth factor like 1	Rattus norvegicus	0-23
8206647-3	1994	Epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) added singly caused significant increases relative to control in both the uptake of [3H]thymidine into the cellular DNA of subconfluent monolayers and of [3H]proline into collagenase-sensitive protein.	Proline	230-237	epidermal growth factor like 1	Rattus norvegicus	25-28
8206647-3	1994	Epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) added singly caused significant increases relative to control in both the uptake of [3H]thymidine into the cellular DNA of subconfluent monolayers and of [3H]proline into collagenase-sensitive protein.	Proline	230-237	myotrophin	Rattus norvegicus	10-23
8302873-8	1994	The GHR contains a proline-rich region, called "Box I," conserved in the cytokine/GH/prolactin receptor family.	Proline	19-26	growth hormone receptor	Homo sapiens	4-7
8113392-3	1994	Addition of neutralizing anti-TGF-beta antibody, but not normal rabbit IgG, significantly reduced the high glucose-stimulated incorporation of 3[H]proline.	Proline	147-154	transforming growth factor, beta 1	Mus musculus	30-38
8294516-6	1994	In addition to the F-actin binding domain, the COOH-terminus of Abl contains a proline-rich region that mediates binding and sequestration of G-actin, and the Abl F- and G-actin binding domains cooperate to bundle F-actin filaments in vitro.	Proline	79-86	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	64-67
8301125-10	1994	Proline at 436 in IgM and 331 in IgG may, however, be a common element.	Proline	0-7	immunoglobulin heavy constant mu	Mus musculus	18-21
8170469-4	1994	The coding region of the hyt/hyt TSHr, compared to that of the +/+ TSHr, has a single base change, CCG to CTG, at nucleotide position 1666, which leads to the replacement of a highly conserved proline at amino acid position 556 with a leucine in transmembrane domain IV.	Proline	193-200	thyroid stimulating hormone receptor	Mus musculus	25-28
8170469-4	1994	The coding region of the hyt/hyt TSHr, compared to that of the +/+ TSHr, has a single base change, CCG to CTG, at nucleotide position 1666, which leads to the replacement of a highly conserved proline at amino acid position 556 with a leucine in transmembrane domain IV.	Proline	193-200	thyroid stimulating hormone receptor	Mus musculus	29-32
8170469-4	1994	The coding region of the hyt/hyt TSHr, compared to that of the +/+ TSHr, has a single base change, CCG to CTG, at nucleotide position 1666, which leads to the replacement of a highly conserved proline at amino acid position 556 with a leucine in transmembrane domain IV.	Proline	193-200	thyroid stimulating hormone receptor	Mus musculus	33-37
8170469-4	1994	The coding region of the hyt/hyt TSHr, compared to that of the +/+ TSHr, has a single base change, CCG to CTG, at nucleotide position 1666, which leads to the replacement of a highly conserved proline at amino acid position 556 with a leucine in transmembrane domain IV.	Proline	193-200	thyroid stimulating hormone receptor	Mus musculus	67-71
8311446-3	1994	Addition of bFGF at 3 ng/ml stimulated cell mitotic activity (total DNA) and synthesis of proteoglycan ([35S]sulfate incorporation), protein ([3H]proline incorporation), and collagen (formation of [3H]hydroxyproline), and resulted in a slight increase in proteoglycan deposition compared to basal medium.	Proline	146-153	fibroblast growth factor 2	Bos taurus	12-16
8121811-0	1994	CTD-like sequences are important for transcriptional activation by the proline-rich activation domain of CTF1.	Proline	71-78	CTD	Homo sapiens	0-3
8121811-0	1994	CTD-like sequences are important for transcriptional activation by the proline-rich activation domain of CTF1.	Proline	71-78	cardiotrophin 1	Homo sapiens	105-109
8288572-11	1994	RhoGAP contains a proline-rich sequence, suggesting that it is an SH3-binding protein.	Proline	18-25	Rho GTPase activating protein 1	Homo sapiens	0-6
8288579-5	1994	This domain is proline and glutamine-rich and is highly homologous (66%) to a portion of vHNF1, an evolutionarily related gene first identified in dedifferentiated hepatoma cells.	Proline	15-22	HNF1 homeobox B	Homo sapiens	89-94
8276883-5	1994	One such site II mutant protein (with double substitution of Gln-160 with Glu and Thr-163 with Pro) was found to be an antagonist of human IL-6.	Proline	95-98	interleukin 6	Homo sapiens	139-143
7517023-2	1994	Dephosphorylation was monitored by immunoblotting with two monoclonal antibodies, TAU-1 and SMI31, which recognize in tau the dephospho- and phospho-states, respectively, of proline-directed protein kinase phosphorylation sites.	Proline	174-181	microtubule associated protein tau	Homo sapiens	118-121
8294442-1	1994	Src homology 3 (SH3) domains have been recently shown to bind to proline-rich sequences contained in 3BP1, 3BP2, and SOS.	Proline	65-72	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
8294442-1	1994	Src homology 3 (SH3) domains have been recently shown to bind to proline-rich sequences contained in 3BP1, 3BP2, and SOS.	Proline	65-72	xylosyltransferase 2	Homo sapiens	117-120
8294442-4	1994	An examination of p85 amino acid sequence revealed two proline-rich sequences in its N-terminal region similar to those present in 3BP1, 3BP2, and SOS.	Proline	55-62	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	18-21
8294442-5	1994	To test whether these sequences mediate the association of p85 with SH3 domains two peptides with amino acid composition corresponding to the p85 alpha proline-rich sequences were synthesized and used in competition assays.	Proline	152-159	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	142-151
8294442-7	1994	These results indicate that, as in 3BP1 and SOS, the proline-rich sequences in p85 mediate its interaction with SH3 domains.	Proline	53-60	xylosyltransferase 2	Homo sapiens	32-47
8294442-7	1994	These results indicate that, as in 3BP1 and SOS, the proline-rich sequences in p85 mediate its interaction with SH3 domains.	Proline	53-60	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	79-82
8294442-8	1994	These results also suggest that the SH3 domain of p85 may "self-associate" with the proline-rich motifs of the same subunit as part of the PI 3-kinase regulatory mechanism.	Proline	84-91	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	50-53
8276845-14	1994	The VCS-beta 1 cDNA codes for a proline-rich protein precursor named PR-V beta 1 (148 amino acids, 39.2% proline, 10.8% glycine) and characterized by a secretory signal-peptide and three repeats of a unit rich in proline residues surrounded by two clusters of potential endoprotease cleavage sites.	Proline	32-39	submaxillary gland androgen regulated protein 3A	Rattus norvegicus	4-14
8276845-14	1994	The VCS-beta 1 cDNA codes for a proline-rich protein precursor named PR-V beta 1 (148 amino acids, 39.2% proline, 10.8% glycine) and characterized by a secretory signal-peptide and three repeats of a unit rich in proline residues surrounded by two clusters of potential endoprotease cleavage sites.	Proline	32-39	submaxillary gland androgen regulated protein 3A	Rattus norvegicus	69-80
8276845-14	1994	The VCS-beta 1 cDNA codes for a proline-rich protein precursor named PR-V beta 1 (148 amino acids, 39.2% proline, 10.8% glycine) and characterized by a secretory signal-peptide and three repeats of a unit rich in proline residues surrounded by two clusters of potential endoprotease cleavage sites.	Proline	105-112	submaxillary gland androgen regulated protein 3A	Rattus norvegicus	4-14
8276845-14	1994	The VCS-beta 1 cDNA codes for a proline-rich protein precursor named PR-V beta 1 (148 amino acids, 39.2% proline, 10.8% glycine) and characterized by a secretory signal-peptide and three repeats of a unit rich in proline residues surrounded by two clusters of potential endoprotease cleavage sites.	Proline	105-112	proline rich protein 2-like 1	Rattus norvegicus	32-52
8276845-14	1994	The VCS-beta 1 cDNA codes for a proline-rich protein precursor named PR-V beta 1 (148 amino acids, 39.2% proline, 10.8% glycine) and characterized by a secretory signal-peptide and three repeats of a unit rich in proline residues surrounded by two clusters of potential endoprotease cleavage sites.	Proline	105-112	submaxillary gland androgen regulated protein 3A	Rattus norvegicus	69-80
8276845-16	1994	PR-V beta 1 is homologous to the proline-rich peptide B isolated from human saliva (Isemura, S., Saitoh, E., and Sanada, K. (1979) J. Biochem.	Proline	33-40	submaxillary gland androgen regulated protein 3A	Rattus norvegicus	0-11
7858169-8	1994	The loss of ARSA activity is due to a point mutation C &gt; T leading to a change of proline to leucine.	Proline	85-92	arylsulfatase A	Homo sapiens	12-16
7517709-3	1994	Competition ELISA experiments defined a proline and lysine rich octapeptide PKPEPKPK as the major epitope recognized by more than 70% of the HMG-17 positive JRA sera.	Proline	40-47	high mobility group nucleosomal binding domain 2	Homo sapiens	141-147
7764512-3	1994	The cystatin consists of 111 amino acid residues with two disulfide linkages formed between 66-75 and 89-109, and has 43% identical sequences with chicken egg-white cystatin with consensus sequences of reactive sites, Gly(4), Gln-X-Val-X-Gly (48-52), and Ile(Val)-Pro-Trp (96-98).	Proline	264-267	cystatin C	Gallus gallus	4-12
8262987-1	1993	Amino acid substitutions at Thr199 of human carbonic anhydrase II (CAII) (Thr199--&gt;Ser, Ala, Val, and Pro) were characterized to investigate the importance of a conserved hydrogen bonding network.	Proline	105-108	carbonic anhydrase 2	Homo sapiens	44-65
8302579-5	1994	Shb contains the proline-rich sequence PPPGPGR between the two proposed initiator methionines which resembles a sequence for binding to Src homology 3 (SH3) domains.	Proline	17-24	src homology 2 domain-containing transforming protein B	Mus musculus	0-3
8302579-14	1994	It is concluded that Shb is a novel SH2-containing protein with proline-rich domains and therefore probably involved in the signal-transduction of some ligand-activated tyrosine kinase receptors.	Proline	64-71	src homology 2 domain-containing transforming protein B	Mus musculus	21-24
7911611-1	1994	Dipeptidyl peptidase IV (DPP IV, EC 3.4.14.5) is a highly specific serine protease which cleaves off N-terminal dipeptides from peptides with a penultimate proline or alanine.	Proline	156-163	dipeptidyl peptidase 4	Homo sapiens	0-23
7911611-1	1994	Dipeptidyl peptidase IV (DPP IV, EC 3.4.14.5) is a highly specific serine protease which cleaves off N-terminal dipeptides from peptides with a penultimate proline or alanine.	Proline	156-163	dipeptidyl peptidase 4	Homo sapiens	25-31
7911611-7	1994	N-Peptidyl-O-acylhydroxylamines and boronic acid analogues of proline and alanine are two known DPP IV inhibitors.	Proline	62-69	dipeptidyl peptidase 4	Homo sapiens	96-102
8262937-0	1993	Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin.	Proline	43-50	RAS p21 protein activator 1	Homo sapiens	94-102
8262937-0	1993	Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin.	Proline	43-50	neurofibromin 1	Homo sapiens	107-120
8187209-3	1994	This was achieved by the addition of proline as a dissociating agent to all buffers during Lp(a) preparation.	Proline	37-44	lipoprotein(a)	Homo sapiens	91-96
8068820-1	1994	Prolyl endopeptidase is a serine protease that specifically cleaves peptides on the carboxyl side of proline residues.	Proline	101-108	prolyl endopeptidase	Mus musculus	0-20
8262987-1	1993	Amino acid substitutions at Thr199 of human carbonic anhydrase II (CAII) (Thr199--&gt;Ser, Ala, Val, and Pro) were characterized to investigate the importance of a conserved hydrogen bonding network.	Proline	105-108	carbonic anhydrase 2	Homo sapiens	67-71
8267567-6	1993	In the affected males of kindred B, a G to C substitution was found at nucleotide 428, altering codon 143 from arginine (CGT) to proline (CCT) in the second cytoplasmic domain.	Proline	129-136	CCT	Homo sapiens	138-141
8262198-0	1993	The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain.	Proline	53-60	MAP kinase-activated protein kinase 2	Mus musculus	4-41
8262198-1	1993	The protein sequence of MAP kinase-activated protein kinase 2 (MAPKAP kinase 2) deduced from mouse cDNA sequence reveals structural features of the enzyme, which could be of importance for its function: a proline-rich SH3-binding domain N-terminal to the catalytic region, a MAP kinase phosphorylation site and a bipartite nuclear targeting sequence located C-terminal to the catalytic region.	Proline	205-212	MAP kinase-activated protein kinase 2	Mus musculus	24-61
8262198-1	1993	The protein sequence of MAP kinase-activated protein kinase 2 (MAPKAP kinase 2) deduced from mouse cDNA sequence reveals structural features of the enzyme, which could be of importance for its function: a proline-rich SH3-binding domain N-terminal to the catalytic region, a MAP kinase phosphorylation site and a bipartite nuclear targeting sequence located C-terminal to the catalytic region.	Proline	205-212	MAP kinase-activated protein kinase 2	Mus musculus	63-78
8253805-0	1993	Primary structure of the soluble lactose binding lectin L-29 from rat and dog and interaction of its non-collagenous proline-, glycine-, tyrosine-rich sequence with bacterial and tissue collagenase.	Proline	117-124	galectin 3	Rattus norvegicus	49-60
7907802-1	1993	Neuropeptide Y, peptide YY and pancreatic polypeptide share an evolutionary conserved proline-rich N-terminal sequence, a structure generally known to be inert to the attack of common proteinases, but a potential target for specialized proline-specific aminopeptidases.	Proline	86-93	neuropeptide Y	Homo sapiens	0-14
7907802-1	1993	Neuropeptide Y, peptide YY and pancreatic polypeptide share an evolutionary conserved proline-rich N-terminal sequence, a structure generally known to be inert to the attack of common proteinases, but a potential target for specialized proline-specific aminopeptidases.	Proline	236-243	neuropeptide Y	Homo sapiens	0-14
7907802-3	1993	Other proline-specific aminopeptidases exhibited low (aminopeptidase P, liberation of N-terminal Tyr) or totally no activity (dipeptidyl peptidase II), as was also observed with less-specific aminopeptidases (aminopeptidase M, leucine aminopeptidase).	Proline	6-13	carboxypeptidase Q	Homo sapiens	23-37
7907802-3	1993	Other proline-specific aminopeptidases exhibited low (aminopeptidase P, liberation of N-terminal Tyr) or totally no activity (dipeptidyl peptidase II), as was also observed with less-specific aminopeptidases (aminopeptidase M, leucine aminopeptidase).	Proline	6-13	dipeptidyl peptidase 7	Homo sapiens	126-149
7907802-3	1993	Other proline-specific aminopeptidases exhibited low (aminopeptidase P, liberation of N-terminal Tyr) or totally no activity (dipeptidyl peptidase II), as was also observed with less-specific aminopeptidases (aminopeptidase M, leucine aminopeptidase).	Proline	6-13	alanyl aminopeptidase, membrane	Homo sapiens	209-225
7907802-3	1993	Other proline-specific aminopeptidases exhibited low (aminopeptidase P, liberation of N-terminal Tyr) or totally no activity (dipeptidyl peptidase II), as was also observed with less-specific aminopeptidases (aminopeptidase M, leucine aminopeptidase).	Proline	6-13	carboxypeptidase Q	Homo sapiens	54-68
8276894-17	1993	Two mutant H2b proteins, with either a glycine or proline substitution at the position of insertion of the pentapeptide in H2a, have metabolic fates similar to that of H2a.	Proline	50-57	H2B clustered histone 21	Homo sapiens	11-14
8276902-1	1993	Synapsin I is a synaptic vesicle-specific phosphoprotein composed of a globular and hydrophobic head and of a proline-rich, elongated and basic tail.	Proline	110-117	synapsin I	Homo sapiens	0-10
8274400-3	1993	Sequence analysis of the human ER reveals a putative PEST sequence, sequences rich in proline (P), glutamic acid (E), serine (S) and threonine (T), in the carboxy-terminal F domain of the protein.	Proline	86-93	estrogen receptor 1	Homo sapiens	31-33
8250863-3	1993	The carboxyl-moiety of the predicted protein is identical to the mature form of the proline- and arginine-rich antibacterial peptide named PR-39, isolated from pig intestine.	Proline	84-91	antibacterial protein PR-39	Sus scrofa	139-144
8246952-7	1993	In contrast to the results obtained with p120GAP, the Pro-34--&gt;Arg p21 species is effectively coupled to the raf-1 product, as judged from electrophoretic mobility shifts of the Raf-1 phosphoprotein.	Proline	54-57	H3 histone pseudogene 16	Homo sapiens	70-73
8246952-7	1993	In contrast to the results obtained with p120GAP, the Pro-34--&gt;Arg p21 species is effectively coupled to the raf-1 product, as judged from electrophoretic mobility shifts of the Raf-1 phosphoprotein.	Proline	54-57	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	112-117
8246952-7	1993	In contrast to the results obtained with p120GAP, the Pro-34--&gt;Arg p21 species is effectively coupled to the raf-1 product, as judged from electrophoretic mobility shifts of the Raf-1 phosphoprotein.	Proline	54-57	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	181-186
8221676-5	1993	Genet., 7: 125-155, 1990) recently proposed a model of the secondary structure of proline rich tandem repeat proteins that has challenged this idea, especially for the case of the human polymorphic epithelial mucin encoded by the muc-1 gene.	Proline	82-89	mucin 1, cell surface associated	Homo sapiens	186-214
8221676-5	1993	Genet., 7: 125-155, 1990) recently proposed a model of the secondary structure of proline rich tandem repeat proteins that has challenged this idea, especially for the case of the human polymorphic epithelial mucin encoded by the muc-1 gene.	Proline	82-89	mucin 1, cell surface associated	Homo sapiens	230-235
7513216-6	1993	The threonine and serine residues followed by proline that are conserved between Xenopus and human cdc25 have been mutated.	Proline	46-53	cell division cycle 25C	Homo sapiens	99-104
8265181-6	1993	Amino acid analysis showed the cleft palate mucin to have an amino acid composition similar to other mucins, with serine, threonine, and proline constituting 41% by weight of the protein core.	Proline	137-144	LOC100508689	Homo sapiens	44-49
8241277-2	1993	The nucleotide sequence of the cDNA predicts a protein (RNPS1, 41 x 10(3) M(r) with two nucleic acid-binding domains separated by a proline-rich spacer.	Proline	132-139	RNA binding protein with serine rich domain 1	Mus musculus	56-61
8106171-4	1993	Moreover, a histidine substitutes for a highly conserved proline at position 7 of the MSX2 homeodomain exclusively in affected members.	Proline	57-64	msh homeobox 2	Homo sapiens	86-90
8106277-6	1993	The results indicate that (a) intracellular MHC molecules show higher peptide-binding capacity, (b) peptides that are about 18-25 amino acids long need only a core region of 11 amino acids for binding, (c) specific positions of the peptides are important for DR1 binding, (d) most of the naturally processed peptides show a proline at position 2 or 3 that may represent a stop signal for trimming, and (e) Ii peptides are very abundant in DR1 peptide pools derived from intracellular compartments.	Proline	324-331	major histocompatibility complex, class I, C	Homo sapiens	44-47
8219225-4	1993	Introduction of as few as 13 murine residues (six of 13 variables) into the N-terminal region of hu-PAR abrogated binding to recombinant human pro-u-PA, whereas the opposite chimera, a mu-PAR carrying six of 13 human residues, was positive for binding.	Proline	143-147	jumping translocation breakpoint	Homo sapiens	100-103
8219225-4	1993	Introduction of as few as 13 murine residues (six of 13 variables) into the N-terminal region of hu-PAR abrogated binding to recombinant human pro-u-PA, whereas the opposite chimera, a mu-PAR carrying six of 13 human residues, was positive for binding.	Proline	143-147	plasminogen activator, urokinase	Mus musculus	98-102
8297798-3	1993	The MEK2 protein bears substantial sequence homology to MEK1, except at its amino terminus, and at a proline-rich region insert between the conserved kinase subdomains 9 and 10.	Proline	101-108	mitogen-activated protein kinase kinase 2	Mus musculus	4-8
8226879-0	1993	Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer"s paired helical filaments.	Proline	6-13	microtubule associated protein tau	Homo sapiens	53-56
8226879-0	1993	Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer"s paired helical filaments.	Proline	6-13	microtubule associated protein tau	Homo sapiens	104-107
8240286-2	1993	To perturb the tetrameric structure of yeast phosphoglycerate mutase we have prepared a mutant enzyme in which Lys-168 in the subunit-contact region has been replaced by proline.	Proline	170-177	phosphoglycerate mutase	Saccharomyces cerevisiae S288C	45-68
8136277-2	1993	Molecular analysis has shown that each is a compound heterozygote for a previously described mutation affecting the poly A addition signal (AATAAA-->AATAAG) and a previously undescribed mutation involving a T-->C transition in codon 29 of the alpha 2 gene causing a leucine-->proline substitution.	Proline	276-283	glycoprotein hormone subunit alpha 2	Homo sapiens	243-250
8409432-6	1993	In addition, aminopeptidase treatment of DR1: self-peptide complexes implied that proline together with sterical constraints of the MHC molecule do protect the peptides" NH2-termini from further processing, whereas their COOH-termini were accessible to cathepsin B processing.	Proline	82-89	down-regulator of transcription 1	Homo sapiens	41-44
8406860-2	1993	An eight-amino-acid, proline-containing linker was included between the LT-B and ST moieties.	Proline	21-28	lymphotoxin B	Mus musculus	72-76
8308464-5	1993	The unique and most important substitution in dogfish angiotensin I is a proline residue at position 3 which may cause significant changes in its tertiary structure.	Proline	73-80	angiotensinogen	Homo sapiens	54-67
8409432-5	1993	Proline revealed to function as a stop signal for NH2-terminal trimming as well as a secondary anchor: crude cytosolic and endosomal peptide fractions could be processed by aminopeptidases in vitro, whereupon DR1 binding peptides with increased affinity were generated.	Proline	0-7	down-regulator of transcription 1	Homo sapiens	209-212
8409432-6	1993	In addition, aminopeptidase treatment of DR1: self-peptide complexes implied that proline together with sterical constraints of the MHC molecule do protect the peptides" NH2-termini from further processing, whereas their COOH-termini were accessible to cathepsin B processing.	Proline	82-89	cathepsin B	Homo sapiens	253-264
7906965-4	1993	This change results in the substitution of glutamine-78 in the PVXDX coat protein for proline in PVXDX4.	Proline	86-93	coat protein	Potato virus X	69-81
8134310-0	1993	Chronic intracerebroventricular infusion of the antiopioid peptide, Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF), downregulates mu opioid binding sites in rat brain.	Proline	84-87	neuropeptide FF-amide peptide precursor	Rattus norvegicus	105-109
8413279-4	1993	Three of the activation domains are similar to those characterized previously: one contains a large number of acidic residues, another is enriched in proline and glutamine residues, and another has some sequence homology to a domain found in Krox-20.	Proline	150-157	early growth response 2	Homo sapiens	242-249
8414510-0	1993	MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13.	Proline	65-72	MLLT3 super elongation complex subunit	Homo sapiens	0-5
8414510-0	1993	MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13.	Proline	65-72	MLLT1 super elongation complex subunit	Homo sapiens	100-105
8414510-3	1993	We also isolated a normal MLLT3 cDNA and found an open reading frame encoding at least 318 amino acids with high serine/proline content (24.8%).	Proline	120-127	MLLT3 super elongation complex subunit	Homo sapiens	26-31
8240352-1	1993	The insulin receptor substrate 1 (IRS-1) contains at least 11 sequence motifs that are rich in proline (P), glutamic acid (E), serine (S), and threonine (T), i.e., PEST regions.	Proline	95-102	insulin receptor substrate 1	Rattus norvegicus	4-32
7507619-7	1993	Current evidence suggests that protein kinases or protein phosphatases with a specificity for serine/threonine-proline residues are involved in the abnormal phosphorylation of tau.	Proline	111-118	microtubule associated protein tau	Homo sapiens	176-179
8240352-1	1993	The insulin receptor substrate 1 (IRS-1) contains at least 11 sequence motifs that are rich in proline (P), glutamic acid (E), serine (S), and threonine (T), i.e., PEST regions.	Proline	95-102	insulin receptor substrate 1	Rattus norvegicus	34-39
8238372-4	1993	The uptake of [3H]proline into collagenase-sensitive protein increased in a dose-dependent manner for concentrations of tumor necrosis factor-alpha &gt; or = 1.0 ng/ml.	Proline	18-25	tumor necrosis factor	Rattus norvegicus	120-147
8218160-0	1993	Structure and energetics of a non-proline cis-peptidyl linkage in a proline-202--&gt;alanine carbonic anhydrase II variant.	Proline	34-41	carbonic anhydrase 2	Homo sapiens	93-114
8218160-0	1993	Structure and energetics of a non-proline cis-peptidyl linkage in a proline-202--&gt;alanine carbonic anhydrase II variant.	Proline	68-75	carbonic anhydrase 2	Homo sapiens	93-114
8218160-1	1993	The crystal structure of a human carbonic anhydrase II (CAII) variant, cis-proline-202--&gt;alanine (P202A), has been determined at 1.7-A resolution, indicating that the wild-type geometry, including the cis-peptidyl linkage, is retained upon substitution of proline by alanine.	Proline	75-82	carbonic anhydrase 2	Homo sapiens	33-54
8218160-1	1993	The crystal structure of a human carbonic anhydrase II (CAII) variant, cis-proline-202--&gt;alanine (P202A), has been determined at 1.7-A resolution, indicating that the wild-type geometry, including the cis-peptidyl linkage, is retained upon substitution of proline by alanine.	Proline	75-82	carbonic anhydrase 2	Homo sapiens	56-60
8402653-5	1993	The proline at position 140 in mammalian AGTs is replaced by alanine in the Ada and yeast AGTs and by serine in the Ogt AGT.	Proline	4-11	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	116-119
8402653-5	1993	The proline at position 140 in mammalian AGTs is replaced by alanine in the Ada and yeast AGTs and by serine in the Ogt AGT.	Proline	4-11	angiotensinogen	Homo sapiens	41-44
8402653-6	1993	These results suggest that this proline residue affects the configuration of the active site allowing the O6-benzylguanine to enter and react with the mammalian AGT.	Proline	32-39	angiotensinogen	Homo sapiens	161-164
8402898-3	1993	Selective binding to a subset of 15 different recombinant SH3 domains occurs through proline-rich sequence motifs similar to those that mediate the interaction of the SH3 domains of Grb2 and Abl proteins to the guanine nucleotide exchange protein, Sos, and to the 3BP1 protein, respectively.	Proline	85-92	growth factor receptor bound protein 2	Homo sapiens	182-186
8402898-3	1993	Selective binding to a subset of 15 different recombinant SH3 domains occurs through proline-rich sequence motifs similar to those that mediate the interaction of the SH3 domains of Grb2 and Abl proteins to the guanine nucleotide exchange protein, Sos, and to the 3BP1 protein, respectively.	Proline	85-92	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	191-194
8402898-3	1993	Selective binding to a subset of 15 different recombinant SH3 domains occurs through proline-rich sequence motifs similar to those that mediate the interaction of the SH3 domains of Grb2 and Abl proteins to the guanine nucleotide exchange protein, Sos, and to the 3BP1 protein, respectively.	Proline	85-92	SH3 domain binding protein 1	Homo sapiens	264-268
8413670-8	1993	Mutation of this proline (Pro 87) in connexin 26 causes a reversal in the voltage-gating response when the mutant hemichannel is paired with wild-type connexin 26 in the Xenopus oocyte system.	Proline	17-24	gap junction protein beta 2 L homeolog	Xenopus laevis	37-48
8413670-8	1993	Mutation of this proline (Pro 87) in connexin 26 causes a reversal in the voltage-gating response when the mutant hemichannel is paired with wild-type connexin 26 in the Xenopus oocyte system.	Proline	17-24	gap junction protein beta 2 L homeolog	Xenopus laevis	151-162
8413670-8	1993	Mutation of this proline (Pro 87) in connexin 26 causes a reversal in the voltage-gating response when the mutant hemichannel is paired with wild-type connexin 26 in the Xenopus oocyte system.	Proline	26-29	gap junction protein beta 2 L homeolog	Xenopus laevis	37-48
8413670-8	1993	Mutation of this proline (Pro 87) in connexin 26 causes a reversal in the voltage-gating response when the mutant hemichannel is paired with wild-type connexin 26 in the Xenopus oocyte system.	Proline	26-29	gap junction protein beta 2 L homeolog	Xenopus laevis	151-162
8400282-1	1993	Although the erythropoietin receptor (EpR) lacks a tyrosine kinase consensus sequence within its proline-rich intracellular domain, addition of its ligand to Ep-responsive cells stimulates the rapid and transient tyrosine phosphorylation of a number of cellular proteins.	Proline	97-104	erythropoietin receptor	Homo sapiens	13-36
8400282-1	1993	Although the erythropoietin receptor (EpR) lacks a tyrosine kinase consensus sequence within its proline-rich intracellular domain, addition of its ligand to Ep-responsive cells stimulates the rapid and transient tyrosine phosphorylation of a number of cellular proteins.	Proline	97-104	erythropoietin receptor	Homo sapiens	38-41
8407917-4	1993	The addition of purified pyroglutamyl aminopeptidase resulted in the transformation of TRH-Gly to His-Pro-Gly and cyclo (His-Pro) but not to TRH.	Proline	102-105	thyrotropin releasing hormone	Homo sapiens	87-90
8407918-0	1993	Transcriptional activation in yeast by the proline-rich activation domain of human CTF1.	Proline	43-50	cardiotrophin 1	Homo sapiens	83-87
8407918-2	1993	In vivo and in vitro assays have been employed to demonstrate transcriptional enhancement in yeast by the proline-rich activation domain of human CTF1.	Proline	106-113	cardiotrophin 1	Homo sapiens	146-150
8260540-0	1993	The proline-rich motif (PRM): a novel feature of the cytokine/hematopoietin receptor superfamily.	Proline	4-11	protamine 2	Homo sapiens	24-27
8405806-4	1993	Elastin is found throughout the vertebrate kingdom and possesses an unusual chemical composition rich in glycine, proline, and hydrophobic amino acids, consonant with its characteristic physical properties.	Proline	114-121	elastin	Homo sapiens	0-7
7904558-5	1993	delta EF1 had proline-rich and acidic domains common to various transcriptional activators.	Proline	14-21	zinc finger E-box binding homeobox 1	Gallus gallus	0-9
8404868-0	1993	Degradation of Mos by the N-terminal proline (Pro2)-dependent ubiquitin pathway on fertilization of Xenopus eggs: possible significance of natural selection for Pro2 in Mos.	Proline	37-44	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	15-18
8404868-3	1993	Mos degradation absolutely required its penultimate proline (Pro2) residue and dephosphorylation of the adjacent serine (Ser3) residue.	Proline	52-59	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	0-3
8260540-4	1993	The proline-rich motif (PRM) can be divided into two complementary families that have superimposable consensus sequences.	Proline	4-11	protamine 2	Homo sapiens	24-27
8260540-6	1993	The first motif (PRM1) has the sequence Al-Ar-Pro-X-Al-Pro-X-Pro, while the second (PRM2) is Ar-X-X-X-Al-Pro-X-Pro.	Proline	46-49	protamine 1	Homo sapiens	17-21
8211113-5	1993	Unlike PRP11, SAP 62 contains 22 proline-rich heptapeptide repeats at the carboxyl-terminus.	Proline	33-40	splicing factor 3a subunit 2	Homo sapiens	14-20
8219069-4	1993	The protein contains basic, acidic, and proline/glutamine-rich motifs and has significant amino acid sequence homology to the rice GT-2 factor, including three regions of 50-75 amino acids each of greater than 60% identity.	Proline	40-47	Duplicated homeodomain-like superfamily protein	Arabidopsis thaliana	131-135
8378076-6	1993	Northern analysis with LTG19 cDNA demonstrated the identical gene, encoding serine/proline rich 559 amino acid polypeptide, to be involved in all three cell lines.	Proline	83-90	MLLT1 super elongation complex subunit	Homo sapiens	23-28
8373419-3	1993	The result suggests that the N-substituted structure of proline immediately following the site is important for cdc2 kinase phosphorylation.	Proline	56-63	cyclin dependent kinase 1	Homo sapiens	112-116
7690758-6	1993	A distinct loop configuration of VL-CDR3 appears in models having either a Pro, Gly, or Ala insertion at position 95A.	Proline	75-78	CDR3	Homo sapiens	36-40
8378328-6	1993	These data suggest that the heterogeneous 11q23 abnormalities might cause attachment of Ser/Pro-rich segments to the NH2 terminus of MLL, lacking the zinc-finger region, and that translocations occur in early hematopoietic cells, before commitment to distinct lineages.	Proline	92-95	lysine methyltransferase 2A	Homo sapiens	133-136
8268045-4	1993	hPTHrP 1-84, 1-108, and 1-141 were qualitatively similar to hPTHrP 1-34 and PTH 1-34 in stimulating 45Ca release from both neonatal mouse calvariae and fetal rat long bones and in inhibiting the incorporation of [3H]-proline into collagenase digestible protein (CDP) and stimulating the incorporation of [3H]-thymidine (3H-TdR) in neonatal mouse calvariae.	Proline	217-224	parathyroid hormone like hormone	Homo sapiens	0-6
8244391-0	1993	A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease.	Proline	13-20	serpin family A member 3	Homo sapiens	53-77
8352280-1	1993	A rare germ-line polymorphism in codon 47 of the p53 gene replaces the wild-type proline (CCG) with a serine (TCG).	Proline	81-88	tumor protein p53	Homo sapiens	49-52
8103491-4	1993	The predicted Xlim-3 protein contains two copies of the LIM domain, a homeodomain, and a C-terminal region rich in proline, glycine, and serine.	Proline	115-122	LIM homeobox 3 L homeolog	Xenopus laevis	14-20
8375398-1	1993	Two antibacterial peptides, cecropin P1 and PR-39 (39-residue proline/arginine-rich peptide), from the upper part of pig small intestine have previously been isolated and characterized.	Proline	62-69	antibacterial protein PR-39	Sus scrofa	28-49
7689645-9	1993	These data are compatible with the view that different protein kinases, possibly including casein kinase II and proline-directed protein kinases, might regulate the state of phosphorylation of MAP1B in distinct localizations along the development of different neuronal populations in the brain.	Proline	112-119	microtubule-associated protein 1B	Rattus norvegicus	193-198
7689724-9	1993	Proline at the +3 position relative to Tyr-1021 is crucial in conferring specificity for binding to PLC-gamma 1.	Proline	0-7	phospholipase C, gamma 1	Rattus norvegicus	100-111
8355691-5	1993	HSF activation in response to treatment with sodium arsenite or the proline analog azetidine was also depressed in hsp70-expressing cells relative to that in the nontransfected control cells.	Proline	68-75	interleukin 6	Homo sapiens	0-3
8355691-5	1993	HSF activation in response to treatment with sodium arsenite or the proline analog azetidine was also depressed in hsp70-expressing cells relative to that in the nontransfected control cells.	Proline	68-75	heat shock protein family A (Hsp70) member 4	Homo sapiens	115-120
8371718-8	1993	Within region 195-215, we used site-directed mutagenesis to demonstrate the importance of Gln-198 of alpha 3 (proline in alpha 2) in determining both the antagonist sensitivity and the agonist sensitivity of neuronal nAChRs.	Proline	110-117	MGC75582, possible similarity to act2 S homeolog	Xenopus laevis	121-128
8235066-0	1993	Increased excretion of proline-containing peptides in dipeptidyl peptidase IV-deficient rats.	Proline	23-30	dipeptidylpeptidase 4	Rattus norvegicus	54-77
8248100-8	1993	The beta-casein cDNA was altered to change the main chymosin cleavage site in beta-casein at position 192-193 in two ways, namely from Leu-Tyr to Pro-Pro and to Leu-stop.	Proline	146-149	casein beta	Bos taurus	4-15
8248100-8	1993	The beta-casein cDNA was altered to change the main chymosin cleavage site in beta-casein at position 192-193 in two ways, namely from Leu-Tyr to Pro-Pro and to Leu-stop.	Proline	146-149	casein beta	Bos taurus	78-89
8248100-8	1993	The beta-casein cDNA was altered to change the main chymosin cleavage site in beta-casein at position 192-193 in two ways, namely from Leu-Tyr to Pro-Pro and to Leu-stop.	Proline	150-153	casein beta	Bos taurus	4-15
8248100-8	1993	The beta-casein cDNA was altered to change the main chymosin cleavage site in beta-casein at position 192-193 in two ways, namely from Leu-Tyr to Pro-Pro and to Leu-stop.	Proline	150-153	casein beta	Bos taurus	78-89
8103453-2	1993	Proline residues located near the processing sites of human prosomatostatin were previously shown to be important for cleavage of the precursor into somatostatin 28 and somatostatin 14 [Gomez, S., Boileau, G., Zollinger, L., Nault, C., Rholam, M. &amp; Cohen, P. (1989) EMBO J.	Proline	0-7	somatostatin	Homo sapiens	149-164
8371983-7	1993	In addition, both p54nrb and PSF are rich in Pro and Gln residues outside the main homology region.	Proline	45-48	non-POU domain containing octamer binding	Homo sapiens	18-24
8371983-7	1993	In addition, both p54nrb and PSF are rich in Pro and Gln residues outside the main homology region.	Proline	45-48	splicing factor proline and glutamine rich	Homo sapiens	29-32
8103453-2	1993	Proline residues located near the processing sites of human prosomatostatin were previously shown to be important for cleavage of the precursor into somatostatin 28 and somatostatin 14 [Gomez, S., Boileau, G., Zollinger, L., Nault, C., Rholam, M. &amp; Cohen, P. (1989) EMBO J.	Proline	0-7	somatostatin	Homo sapiens	169-184
8344943-2	1993	Prolylcarboxypeptidase, a lysosomal serine carboxypeptidase, cleaves COOH-terminal amino acids linked to proline, as in angiotensin II and III and [des-Arg9] bradykinin.	Proline	105-112	prolylcarboxypeptidase	Homo sapiens	0-22
7689231-7	1993	AF4 is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus.	Proline	21-28	AF4/FMR2 family member 1	Homo sapiens	0-3
8395056-6	1993	ZO-1 contains an additional 943-aa C-terminal domain that is proline-rich (14.1%) and contains an alternatively spliced domain, whose expression was previously shown to correlate with variable properties of tight junctions.	Proline	61-68	polychaetoid	Drosophila melanogaster	0-4
8105102-1	1993	Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2) is a recently isolated peptide that belongs to a larger family that includes Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) and MIF-1 (Pro-Leu-Gly-NH2).	Proline	17-20	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	6-11
8105102-1	1993	Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2) is a recently isolated peptide that belongs to a larger family that includes Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) and MIF-1 (Pro-Leu-Gly-NH2).	Proline	17-20	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	115-120
8105102-1	1993	Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2) is a recently isolated peptide that belongs to a larger family that includes Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) and MIF-1 (Pro-Leu-Gly-NH2).	Proline	17-20	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	115-120
8344928-8	1993	In particular, one of the cAMP-dependent protein kinase and the two "proline-directed" kinase-specific sites known to be phosphorylated in rat stathmin are also present in the Xenopus protein.	Proline	69-76	stathmin 1	Rattus norvegicus	143-151
8344943-2	1993	Prolylcarboxypeptidase, a lysosomal serine carboxypeptidase, cleaves COOH-terminal amino acids linked to proline, as in angiotensin II and III and [des-Arg9] bradykinin.	Proline	105-112	kininogen 1	Homo sapiens	158-168
8364154-1	1993	In its dimeric form neuropeptide Y (NPY) folds into a compact structure in which the antiparallel oriented proline and alpha-helices apparently associate to form a primitive hydrophobic core.	Proline	107-114	neuropeptide Y	Rattus norvegicus	20-34
8344891-2	1993	The four sites of phosphorylation associated with p70s6k/p85s6k activation all display Ser/Thr-Pro motifs and are closely clustered within a putative autoinhibitory domain of the enzyme.	Proline	95-98	ribosomal protein S6 kinase B1	Homo sapiens	50-56
8394053-5	1993	In the presence of fMLP-activated W256 cells, [3H]proline release was completely inhibited by the addition of 2000 units/ml catalase or by the metalloproteinase inhibitors 1,10-phenanthroline and EDTA at concentrations &gt; or = 10 micrograms/ml.	Proline	50-57	catalase	Rattus norvegicus	124-132
8364154-1	1993	In its dimeric form neuropeptide Y (NPY) folds into a compact structure in which the antiparallel oriented proline and alpha-helices apparently associate to form a primitive hydrophobic core.	Proline	107-114	neuropeptide Y	Rattus norvegicus	36-39
8364154-3	1993	NPY15-36 is significantly less helical than both NPY and N alpha-acetyl-NPY2-36, and this decreased helical potential is attributed to the absence of the intramolecular stabilizing interaction afforded by the proline helix in the latter analogues.	Proline	209-216	neuropeptide Y	Rattus norvegicus	0-3
8325509-4	1993	The deduced hMel-18 protein contains 344 amino acids (38 kDa) with a RING-finger motif, a helix-loop-helix (HLH)-like structure and a Pro/Ser-rich region.	Proline	134-137	polycomb group ring finger 2	Homo sapiens	12-19
7688677-0	1993	Antibodies to the protein core of the small cell lung cancer workshop antigen cluster-w4 and to the leucocyte workshop antigen CD24 recognize the same short protein sequence leucine-alanine-proline.	Proline	190-197	CD24 molecule	Homo sapiens	127-131
8354270-5	1993	Rat HES-2 protein has a basic HLH domain homologous to h and E(spl) as well as the carboxy-terminal Trp-Arg-Pro-Trp sequence conserved among this family.	Proline	108-111	hes family bHLH transcription factor 2	Rattus norvegicus	4-9
8213254-6	1993	The addition of 3 ng/ml of bFGF resulted in significant enhancement of [3H]thymidine and [3H]proline incorporation and protein accumulation by 12-, 2.5-, and 2.5-fold, respectively.	Proline	93-100	fibroblast growth factor 2	Rattus norvegicus	27-31
8336948-4	1993	Interestingly, eight potential sites of phosphorylation by proline-directed protein kinases conserved between the avian, murine and human Myb proteins are clustered in or near the negative regulatory domain of c-Myb.	Proline	59-66	MYB proto-oncogene, transcription factor	Homo sapiens	138-141
8336948-4	1993	Interestingly, eight potential sites of phosphorylation by proline-directed protein kinases conserved between the avian, murine and human Myb proteins are clustered in or near the negative regulatory domain of c-Myb.	Proline	59-66	MYB proto-oncogene, transcription factor	Homo sapiens	210-215
8336948-6	1993	In this paper we show that one proline-directed protein kinase, p42mapk, phosphorylates bacterially synthesized avian and murine c-Myb but not AMV v-Myb in vitro.	Proline	31-38	mitogen-activated protein kinase 1	Mus musculus	64-71
8336948-6	1993	In this paper we show that one proline-directed protein kinase, p42mapk, phosphorylates bacterially synthesized avian and murine c-Myb but not AMV v-Myb in vitro.	Proline	31-38	myeloblastosis oncogene	Mus musculus	129-134
8336948-6	1993	In this paper we show that one proline-directed protein kinase, p42mapk, phosphorylates bacterially synthesized avian and murine c-Myb but not AMV v-Myb in vitro.	Proline	31-38	MYB proto-oncogene, transcription factor	Homo sapiens	131-134
8210513-0	1993	Inhibitory effect of neurotensin on proline.	Proline	36-43	neurotensin	Rattus norvegicus	21-32
8210513-1	1993	The effect of neurotensin (NT) on proline absorption across rat jejunum was investigated using the single-pass perfusion technique.	Proline	34-41	neurotensin	Rattus norvegicus	14-25
8210513-1	1993	The effect of neurotensin (NT) on proline absorption across rat jejunum was investigated using the single-pass perfusion technique.	Proline	34-41	neurotensin	Rattus norvegicus	27-29
8343583-0	1993	CD of proline-rich polypeptides: application to the study of the repetitive domain of maize glutelin-2.	Proline	6-13	prolamin 27 kDa gamma zein	Zea mays	92-102
8210513-2	1993	This study showed that intravenous administration of NT produced a dose-dependent inhibition of proline absorption.	Proline	96-103	neurotensin	Rattus norvegicus	53-55
8210513-3	1993	Thus, NT at a 0.16 pmol/kg/min concentration gave 10% decrease in proline absorption while 0.32 and 1.6 pmol/kg/min concentration gave 31% and 45% decrease, respectively.	Proline	66-73	neurotensin	Rattus norvegicus	6-8
8210513-8	1993	NT inhibited proline absorption through an indirect mechanism that is Na-dependent and independent of changes in water absorption.	Proline	13-20	neurotensin	Rattus norvegicus	0-2
8325880-4	1993	In conjunction with in vitro phosphorylation experiments, using purified wild-type and mutant Op18 proteins in combination with a series of kinases, these results have identified two distinct proline-directed kinase families that phosphorylate Op18 with overlapping but distinct site preference.	Proline	192-199	stathmin 1	Homo sapiens	94-98
8325880-4	1993	In conjunction with in vitro phosphorylation experiments, using purified wild-type and mutant Op18 proteins in combination with a series of kinases, these results have identified two distinct proline-directed kinase families that phosphorylate Op18 with overlapping but distinct site preference.	Proline	192-199	stathmin 1	Homo sapiens	244-248
8101699-9	1993	It is concluded that the intestinal DPP IV plays a significant role in the hydrolysis of prolyl peptides and assimilation of proline-rich proteins.	Proline	125-132	dipeptidylpeptidase 4	Rattus norvegicus	36-42
8393820-3	1993	The WT1 protein contains a DNA binding domain consisting of four zinc fingers of the Cys2-His2 class and a proline-glutamine rich region capable of regulating transcription.	Proline	107-114	WT1 transcription factor	Homo sapiens	4-7
7689658-3	1993	In the test tube, several proline-directed kinases, particularly mitogen-activated protein (MAP) and cdc2 kinase, phosphorylate tau on sites that appear to mimic the abnormally phosphorylated sites in AD.	Proline	26-33	microtubule associated protein tau	Homo sapiens	128-131
8393323-2	1993	Of particular interest is the phosphorylation at Ser/Thr-Pro motifs because the resulting state of tau is similar to that found in Alzheimer"s disease, as judged by its immunoreactivity.	Proline	57-60	microtubule associated protein tau	Homo sapiens	99-102
8318538-1	1993	Prolylendopeptidase is a cytoplasmic serine proteinase which hydrolyses peptide bonds at the C-terminal side of prolines.	Proline	112-120	prolyl endopeptidase	Homo sapiens	0-19
8510918-5	1993	Fusion of a 298 amino acid glutamine-proline-rich N-terminal segment of WT1 to the GAL4 DNA binding domain created a potent transcriptional repressor.	Proline	37-44	WT1 transcription factor	Homo sapiens	72-75
8510918-5	1993	Fusion of a 298 amino acid glutamine-proline-rich N-terminal segment of WT1 to the GAL4 DNA binding domain created a potent transcriptional repressor.	Proline	37-44	galectin 4	Homo sapiens	83-87
8510918-8	1993	Site-directed mutagenesis of the WT1 repression domain revealed that deletion of homopolymeric proline and glycine regions, as well as single amino acid changes, partially inactivated the repression function.	Proline	95-102	WT1 transcription factor	Homo sapiens	33-36
8233617-1	1993	Thrombospondin related anonymous protein (TRAP) of Plasmodium falciparum is characterized by the presence of an amino acid motif based on the sequence Trp-Ser-Pro-Cys-Ser-Val-Thr-Cys-Gly (WSPCSVTCG) that is found in a growing family of proteins.	Proline	159-162	TRAP	Homo sapiens	42-46
8100523-2	1993	They either start with Tyr-Ala, His-Ala or His-Ser which might be in part potential targets for dipeptidyl-peptidase IV, a highly specialized aminopeptidase removing dipeptides only from peptides with N-terminal penultimate proline or alanine.	Proline	224-231	dipeptidyl peptidase 4	Homo sapiens	96-119
7685348-11	1993	Sequence analyses reveal that F1-20 has an essentially neutral 30-kDa NH2-terminal domain with an amino acid composition typical of a globular structure and an acidic COOH-terminal domain rich in proline, serine, threonine, and alanine.	Proline	196-203	synaptosomal-associated protein 91	Mus musculus	30-35
8512563-1	1993	The novel protein kinase PK40 (1) was characterized by its ability to phosphorylate Lys-Ser-Pro sites in neurofilament and TAU proteins.	Proline	92-95	microtubule associated protein tau	Homo sapiens	123-126
8504753-3	1993	The spontaneous human P450c17 mutation Ser106--&gt;Pro eliminates all enzymatic activity.	Proline	51-54	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	22-29
8512325-7	1993	As in other HMG-17 proteins, the sequence is characterized by a lysine- and proline-rich central region, which has been implicated in DNA binding.	Proline	76-83	high mobility group nucleosomal binding domain 2	Homo sapiens	12-18
8389669-2	1993	The wild-type of p53 protein exists as at least two forms of variants among human populations, ascribed to amino acid replacement at codon 72 of Arg by Pro.	Proline	152-155	tumor protein p53	Homo sapiens	17-20
8389669-3	1993	In this study, we show that this germ line Arg-Pro polymorphism at codon 72 of the p53 gene is associated with genetically determined susceptibility to smoking-induced lung cancer; a susceptible genotype Pro/Pro has a 1.7-fold higher risk of this cancer compared with other genotypes.	Proline	47-50	tumor protein p53	Homo sapiens	83-86
8388484-11	1993	The EBV and HVP EBNA-2 activation domains share a mixed proline-rich, negatively charged character with a striking conservation of positionally equivalent hydrophobic residues.	Proline	56-63	EBNA-2	Human gammaherpesvirus 4	16-22
8325635-1	1993	SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo.	Proline	70-77	sepiapterin reductase	Homo sapiens	0-3
8388502-8	1993	An alanine at position P4 and a proline at position P2, proximal to the scissile glutamine-glycine pair, appear to be important for 3CPro-mediated cleavage of TBP.	Proline	32-39	TATA-box binding protein	Homo sapiens	159-162
8334517-0	1993	Phosphorylation of tau by proline-directed protein kinase (p34cdc2/p58cyclin A) decreases tau-induced microtubule assembly and antibody SMI33 reactivity.	Proline	26-33	cyclin dependent kinase 1	Homo sapiens	59-66
7901784-8	1993	An antagonist for VIP receptor, [Lys, Pro, Arg, Tyr]-VIP inhibited the VIP-induced increase of plasma AVP, but had little effect on PACAP-induced increase of plasma AVP.	Proline	38-41	vasoactive intestinal peptide	Rattus norvegicus	18-21
7901784-8	1993	An antagonist for VIP receptor, [Lys, Pro, Arg, Tyr]-VIP inhibited the VIP-induced increase of plasma AVP, but had little effect on PACAP-induced increase of plasma AVP.	Proline	38-41	vasoactive intestinal peptide	Rattus norvegicus	53-56
7901784-8	1993	An antagonist for VIP receptor, [Lys, Pro, Arg, Tyr]-VIP inhibited the VIP-induced increase of plasma AVP, but had little effect on PACAP-induced increase of plasma AVP.	Proline	38-41	vasoactive intestinal peptide	Rattus norvegicus	53-56
8334517-1	1993	Tau protein was evaluated as a substrate for a proline-directed protein kinase (p34cdc2/p58cyclin A) which recognizes the phosphorylation site motif X-Ser/Thr-Pro-X.	Proline	159-162	cyclin dependent kinase 1	Homo sapiens	80-87
8502565-3	1993	We report here the characterization of the Rb97D gene, which encodes a protein that is closely related to the Hrb proteins in the RNP motif domain, but has a distinctive proline-rich C-terminal domain.	Proline	170-177	Ribonuclear protein at 97D	Drosophila melanogaster	43-48
7684842-6	1993	The LH beta subunit molecules of both birds had 15 Pro residues at the same positions.	Proline	51-54	luteinizing hormone subunit beta	Homo sapiens	4-11
8512070-2	1993	The substrate, DABCYL-gaba-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS, has been designed to incorporate the renin cleavage site that occurs in the N-terminal peptide of human angiotensinogen.	Proline	35-38	renin	Homo sapiens	111-116
8491783-6	1993	The synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro, that contains the Arg-Gly-Asp (RGD) integrin recognition site, reversibly inhibited entactin-mediated blastocyst outgrowth in a dose-dependent manner, but had no effect on laminin-mediated outgrowth.	Proline	43-46	nidogen 1	Mus musculus	132-140
8506309-5	1993	AF-4, AF-9, and ENL proteins contain nuclear targeting sequences as well as serine-rich and proline-rich regions.	Proline	92-99	AF4/FMR2 family member 1	Homo sapiens	0-4
8506309-5	1993	AF-4, AF-9, and ENL proteins contain nuclear targeting sequences as well as serine-rich and proline-rich regions.	Proline	92-99	MLLT3 super elongation complex subunit	Homo sapiens	6-10
8506309-5	1993	AF-4, AF-9, and ENL proteins contain nuclear targeting sequences as well as serine-rich and proline-rich regions.	Proline	92-99	MLLT1 super elongation complex subunit	Homo sapiens	16-19
8479540-5	1993	Here we show that in rodent fibroblasts, the SH3 domains of Grb2 are bound to the proline-rich carboxy-terminal tail of mSos1, a protein homologous to Drosophila Sos.	Proline	82-89	downstream of receptor kinase	Drosophila melanogaster	60-64
8479540-5	1993	Here we show that in rodent fibroblasts, the SH3 domains of Grb2 are bound to the proline-rich carboxy-terminal tail of mSos1, a protein homologous to Drosophila Sos.	Proline	82-89	SOS Ras/Rac guanine nucleotide exchange factor 1	Mus musculus	120-125
8479540-5	1993	Here we show that in rodent fibroblasts, the SH3 domains of Grb2 are bound to the proline-rich carboxy-terminal tail of mSos1, a protein homologous to Drosophila Sos.	Proline	82-89	SOS Ras/Rac guanine nucleotide exchange factor 1	Mus musculus	121-124
7684842-7	1993	Ten of them shared the same positions with Pro residues in the mammalian LH beta subunits, in which about 20 Pro residues exist.	Proline	43-46	luteinizing hormone subunit beta	Homo sapiens	73-80
8479902-9	1993	The other region of BTEB2 is notably rich in proline, serine, threonine, and alanine residues.	Proline	45-52	Kruppel-like factor 5	Mus musculus	20-25
8097274-5	1993	Since PYY has a proline in the penultimate position it is protected from the attack of most unspecific exopeptidases.	Proline	16-23	peptide YY	Homo sapiens	6-9
8477720-3	1993	With the former, the major cleavage in both proteins involves Lys-Lys-Pro segments, at positions 247-248 in alcohol dehydrogenase, surface-positioned after the most distal beta-strand in the coenzyme-binding domain, and at 61-62 in sorbitol dehydrogenase, at another surface in the catalytic domain.	Proline	70-73	sorbitol dehydrogenase	Homo sapiens	232-254
8464883-6	1993	A control mutant of dMax that contains a proline residue in the leucine-zipper region was unable to bind to N-Myc and did not revert the N-Myc-induced changes in cellular gene expression.	Proline	41-48	Max	Drosophila melanogaster	20-24
8461023-2	1993	The codon 105 point mutation (proline to leucine) was found on a codon 129 (Valine) PrP allele in 4 patients from 3 different Japanese families with Gerstmann-Straussler syndrome.	Proline	30-37	prion protein	Homo sapiens	84-87
8463249-4	1993	Further studies show that the same four major Ser/Thr-Pro sites associated with p70s6k activation following mitogenic stimulation in vivo are also the four major sites phosphorylated in both the p70s6k and p85s6k during the infection process.	Proline	54-57	ribosomal protein S6 kinase B1	Rattus norvegicus	80-86
8463249-4	1993	Further studies show that the same four major Ser/Thr-Pro sites associated with p70s6k activation following mitogenic stimulation in vivo are also the four major sites phosphorylated in both the p70s6k and p85s6k during the infection process.	Proline	54-57	ribosomal protein S6 kinase B1	Rattus norvegicus	195-201
8493987-0	1993	Unstable alpha-chain hemoglobin variants with factitious beta-thalassemia biosynthetic ratio: Hb Questembert (alpha 131[H14]Ser-->Pro) and Hb Caen (alpha 132[H15]Val-->Gly).	Proline	130-133	Fc gamma receptor and transporter	Homo sapiens	9-20
8467072-0	1993	NMR and computer-aided studies of the three interchanging stereoisomers of the cyclic hexapeptide cyclo[-Pro1-Gly2-Glu3(OBzl)-Pro4-Phe5-Leu6-]: unexpected observation of a cis isomer of a secondary amide peptide bond in the presence of two trans proline peptide bonds.	Proline	246-253	lamin A/C	Homo sapiens	105-109
8467794-9	1993	MTF-1 contains six zinc fingers and separate transcriptional activation domains with high contents of acidic and proline residues.	Proline	113-120	metal response element binding transcription factor 1	Mus musculus	0-5
8501199-3	1993	The amino acid composition revealed a high content of cysteines, prolines and amino acids (aa) with acidic side-chains indicating that fetal antigen 1 is a compactly folded, strongly hydrophilic molecule.	Proline	65-73	delta like non-canonical Notch ligand 1	Homo sapiens	135-150
8497191-2	1993	GAP1 activity is regulated by control of synthesis and control of activity in response to the nitrogen source supplied; ammonia and glutamine inactivate GAP1 function while proline and urea allow its maximum expression.	Proline	173-180	amino acid permease GAP1	Saccharomyces cerevisiae S288C	0-4
8384830-6	1993	Comparison with sequences of other cytochromes c indicated the closest similarity to cytochrome c from snapping turtle (Chelydra serpentina) with substitutions at five positions corresponding to residues 32 (His--&gt;Asn), 44 (Glu--&gt;Pro), 89 (Ala--&gt;Pro), 100 (Asp--&gt;Glu), and 104 (Lys--&gt;Asn), respectively.	Proline	236-239	cytochrome c	Alligator mississippiensis	85-97
8449921-3	1993	After 48 h, bFGF (0.1-10 nM) inhibited the incorporation of [3H]proline into collagenase-digestible protein (CDP).	Proline	64-71	fibroblast growth factor 2	Mus musculus	12-16
8449921-3	1993	After 48 h, bFGF (0.1-10 nM) inhibited the incorporation of [3H]proline into collagenase-digestible protein (CDP).	Proline	64-71	cut-like homeobox 1	Mus musculus	77-107
8449921-3	1993	After 48 h, bFGF (0.1-10 nM) inhibited the incorporation of [3H]proline into collagenase-digestible protein (CDP).	Proline	64-71	cut-like homeobox 1	Mus musculus	109-112
8384830-7	1993	The presence of Pro and Asn residues at positions 89 and 104, respectively, are unique to alligator cytochrome c.	Proline	16-19	cytochrome c	Alligator mississippiensis	100-112
8384830-6	1993	Comparison with sequences of other cytochromes c indicated the closest similarity to cytochrome c from snapping turtle (Chelydra serpentina) with substitutions at five positions corresponding to residues 32 (His--&gt;Asn), 44 (Glu--&gt;Pro), 89 (Ala--&gt;Pro), 100 (Asp--&gt;Glu), and 104 (Lys--&gt;Asn), respectively.	Proline	255-258	cytochrome c	Alligator mississippiensis	85-97
8381960-4	1993	The pro-R and pro-S protons of F6P become the anomeric protons of M6P and G6P through the actions of PMI and PGI, respectively.	Proline	4-7	mannose phosphate isomerase	Homo sapiens	101-104
8095483-6	1993	The minimal 57-residue Eve repression domain, as well as several others studied here, were all found to be proline rich and to contain a high percentage of hydrophobic residues.	Proline	107-114	even skipped	Drosophila melanogaster	23-26
8094081-0	1993	Functional consequences of proline mutations in the predicted transmembrane domain of P-glycoprotein.	Proline	27-34	ATP binding cassette subfamily B member 1	Homo sapiens	86-100
8381960-4	1993	The pro-R and pro-S protons of F6P become the anomeric protons of M6P and G6P through the actions of PMI and PGI, respectively.	Proline	4-7	glucose-6-phosphate isomerase	Homo sapiens	109-112
8381960-4	1993	The pro-R and pro-S protons of F6P become the anomeric protons of M6P and G6P through the actions of PMI and PGI, respectively.	Proline	14-17	mannose phosphate isomerase	Homo sapiens	101-104
8381960-4	1993	The pro-R and pro-S protons of F6P become the anomeric protons of M6P and G6P through the actions of PMI and PGI, respectively.	Proline	14-17	glucose-6-phosphate isomerase	Homo sapiens	109-112
8428938-13	1993	Together the observations suggest that the substitution of proline at residue 165 interferes with the formation of a structural domain in apoA-I that is crucial for cellular cholesterol efflux stimulation.	Proline	59-66	apolipoprotein A-I	Mus musculus	138-144
8434006-3	1993	Deletions of &gt; 11 amino acids in the C-terminal proline-rich region resulted in loss of DNA binding activity of wild-type p15.	Proline	51-58	cyclin dependent kinase inhibitor 2B	Homo sapiens	125-128
8434006-5	1993	These results suggest that cauliflower mosaic virus p15 belongs to the family of DNA binding proteins having a proline-rich motif involved in interaction with double-stranded DNA.	Proline	111-118	cyclin dependent kinase inhibitor 2B	Homo sapiens	52-55
8435078-5	1993	Results suggest that a Pro-to-Leu substitution in C4B is likely to account for the differences in inhibitory potency of C4B compared with C4A observed with the aromatic inhibitors.	Proline	23-26	complement C4B (Chido blood group)	Homo sapiens	50-53
8435078-5	1993	Results suggest that a Pro-to-Leu substitution in C4B is likely to account for the differences in inhibitory potency of C4B compared with C4A observed with the aromatic inhibitors.	Proline	23-26	complement C4B (Chido blood group)	Homo sapiens	120-123
8427639-4	1993	The previously undetermined amino acid sequence of rabbit alpha B-crystallin was determined to be the same as the bovine alpha B-crystallin sequence except at three residues: Thr 40, Thr 132, and Pro 153.	Proline	196-199	alpha-crystallin B chain	Oryctolagus cuniculus	58-76
7951486-8	1993	The sequencing of the entire coding exons and exon/intron junctions of TBG allele of the propositus revealed a single nucleotide substitution: CCT (proline) to CTT (leucine) at amino acid 363 of the TBG-C.	Proline	148-155	serpin family A member 7	Homo sapiens	71-74
7951486-10	1993	The proline to leucine substitution may cause a change in the TBG tertiary structure and result in decreased heat stability, resulting in decreased TBG levels in the affected subjects.	Proline	4-11	serpin family A member 7	Homo sapiens	62-65
7951486-10	1993	The proline to leucine substitution may cause a change in the TBG tertiary structure and result in decreased heat stability, resulting in decreased TBG levels in the affected subjects.	Proline	4-11	serpin family A member 7	Homo sapiens	148-151
8094081-1	1993	Site-directed mutagenesis was used to investigate whether prolines in the predicted transmembrane domains play essential roles in the function of human P-glycoprotein.	Proline	58-66	ATP binding cassette subfamily B member 1	Homo sapiens	152-166
8428801-1	1993	Human leukemia cell lines, unlike those from adherent tumors, have been shown to continuously activate the pro-urokinase (pro-u-PA) they produce.	Proline	107-110	plasminogen activator, urokinase	Homo sapiens	126-130
8442433-7	1993	TNF-alpha and TNF-beta (100 ng/ml) stimulated bone matrix breakdown, as assessed by analysis of the release of 3H from bone prelabeled with [3H]proline.	Proline	144-151	tumor necrosis factor	Mus musculus	0-9
8442433-7	1993	TNF-alpha and TNF-beta (100 ng/ml) stimulated bone matrix breakdown, as assessed by analysis of the release of 3H from bone prelabeled with [3H]proline.	Proline	144-151	lymphotoxin A	Mus musculus	14-22
8443603-4	1993	The synthetic peptide Lys-Pro-Ile-Glu-Phe*Nph-Arg-Leu has proven to be an excellent chromogenic substrate for cathepsin D yielding a value of kcat/Km = 0.92 x 10(-6) s-1 M-1 for enzyme isolated from human placenta.	Proline	26-29	cathepsin D	Homo sapiens	110-121
8430097-7	1993	Consistent with the rapid turnover of the tll protein, it contains a PEST sequence (rich in proline, glutamate and aspartate, serine, and threonine) that is also conserved.	Proline	92-99	tailless	Drosophila melanogaster	42-45
8012450-2	1993	Following treatment with endotoxin, endothelial cell monolayers altered their production of [3H] proline-labeled procollagen (types III and V), fibronectin, and a 43 kDa protein, Secreted Protein Acidic and Rich in Cysteines (SPARC).	Proline	97-104	secreted protein acidic and cysteine rich	Bos taurus	226-231
8424781-2	1993	H-189 [Pro-His-Pro-Phe-His-Sta-(statyl)-Val-Ile-His-Lys] is an analogue of human angiotensinogen.	Proline	7-10	GCY	Homo sapiens	27-30
8416958-1	1993	Bac5 is a 5-kDa proline- and arginine-rich antibiotic, stored as inactive precursor (proBac5) in the large granules of bovine neutrophils.	Proline	16-23	cathelicidin-2	Bos taurus	0-4
8061231-1	1993	By using oligonucleotide-mediated site-directed mutagenesis, we obtained three human interleukin-2 analogs with substitution of Pro in the C-terminal amphiphilic alpha-helix, 125Pro-IL-2, 127Pro-IL-2 and 125Pro-127Pro-IL-2.	Proline	128-131	interleukin 2	Homo sapiens	85-98
8418811-6	1993	This cDNA corresponds to a peculiar MCP form previously described, which is characterized by the presence of the serine/threonine/proline-rich exon C (STPC) and the cytoplasmic tail known as CYT2, and we conclude that the absence of mature oligosaccharide of the sperm MCP cannot be totally attributed to a defect of N- and O-glycosylation sequences but rather reflects an alteration of the mechanisms of glycosylation in spermatozoa.	Proline	130-137	CD46 molecule	Homo sapiens	36-39
7680587-7	1993	Motions with high amplitudes have been localized in the Gly-Pro-Gly sequence which forms a beta-turn in both structures.	Proline	60-63	amyloid beta precursor protein	Homo sapiens	89-95
8449008-2	1993	In calvariae treated for 24h with heparin (25 micrograms/ml), a significant inhibition of methyl [3H]thymidine (Tdr) incorporation into DNA and [3H]proline labeling of collagenase-digestible protein (CDP) occurred compared to control.	Proline	148-155	cut-like homeobox 1	Rattus norvegicus	168-198
8422499-3	1993	Each PRB gene is approximately 4.0 kb in length and contains four exons, the third of which is entirely composed of 63-bp tandem repeats and encodes the proline-rich portion of the protein products.	Proline	153-160	RB transcriptional corepressor 1	Homo sapiens	5-8
8446104-3	1993	PGE2 at 1 microM inhibited the incorporation of [3H]proline into collagenase-digestible protein (CDP) and increased incorporation into noncollagen protein, whereas 0.1 microM PGE2 increased both CDP and noncollagen protein labeling.	Proline	52-59	cut-like homeobox 1	Rattus norvegicus	65-95
8446104-3	1993	PGE2 at 1 microM inhibited the incorporation of [3H]proline into collagenase-digestible protein (CDP) and increased incorporation into noncollagen protein, whereas 0.1 microM PGE2 increased both CDP and noncollagen protein labeling.	Proline	52-59	cut-like homeobox 1	Rattus norvegicus	97-100
1472498-4	1992	(ii) Preferences at positions P3, P2, P1, P1", and P2" are for the hydrophobic amino acids Pro, Leu, Ala, Nva, and Trp, respectively.	Proline	91-94	crystallin gamma F, pseudogene	Homo sapiens	34-45
8476653-1	1993	p53 gene which is known as a tumor suppressor gene locates in chromosome 17p and has a polymorphism at codon 72 (Arginine CGC--&gt;Proline CCC).	Proline	131-138	tumor protein p53	Homo sapiens	0-3
8401599-1	1993	Genomic and cDNA clones of the anther-specific APG gene from Arabidopsis thaliana and Brassica napus, which encodes a novel proline-rich protein, were isolated and characterized.	Proline	124-131	anther-specific proline-rich protein APG	Brassica napus	47-50
8401606-5	1993	MFS18 mRNA is particularly associated with the vascular bundle in the glumes and encodes a polypeptide of 12 kDa, rich in glycine, proline and serine that has similarities with other plant structural proteins.	Proline	131-138	MFS18 protein	Zea mays	0-5
8425044-1	1993	The I locus controls inhibition of anthocyanin accumulation in the epidermal cells of the soybean seed coat and affects abundance of PRP1, a proline-rich cell wall protein in the seed coat.	Proline	141-148	repetitive proline-rich cell wall protein 1	Glycine max	133-137
1479581-3	1992	This redidue has previously been shown in the case of HLE to be a good bioisosteric replacement for L-proline.	Proline	100-109	elastase, neutrophil expressed	Homo sapiens	54-57
1334849-1	1992	The Alzheimer-like state of tau protein includes phosphorylation by a proline-directed Ser/Thr kinase present in normal or pathological human brain.	Proline	70-77	microtubule associated protein tau	Homo sapiens	28-31
1294376-5	1992	A single nucleotide substitution in the codon for the amino acid 363 of native TBG molecule (CCT to CTT) was found, resulting in the replacement of proline by leucine.	Proline	148-155	serpin family A member 7	Homo sapiens	79-82
1475183-7	1992	The predicted amino acid sequence of the POP2 protein contains three glutamine-rich region, a proline-rich region and a serine/threonine-rich region, characteristic of many transcription factors.	Proline	94-101	CCR4-NOT core DEDD family RNase subunit POP2	Saccharomyces cerevisiae S288C	41-45
1465135-1	1992	The mammalian shc gene encodes two overlapping, widely expressed proteins of 46 and 52K, with a carboxy-terminal SH2 domain that binds activated growth factor receptors, and a more amino-terminal glycine/proline-rich region.	Proline	204-211	SHC adaptor protein 1	Homo sapiens	14-17
1469049-12	1992	We have now isolated and sequenced zyxin cDNA and we report here that zyxin exhibits an unusual proline-rich NH2-terminus followed by three tandemly arrayed LIM domains.	Proline	96-103	zyxin	Gallus gallus	70-75
1283743-3	1992	As a result of this study a series of low-energy conformations were identified showing a common folding pattern with residues Val-3, Pro-4, His-5 and Lys-6 forming a beta turn.	Proline	133-136	amyloid beta precursor protein	Homo sapiens	164-170
1464321-8	1992	The proline-rich activation domains of AP-2 and CTF/NF1 may represent a third class with considerable promoter activity and low but significant enhancer activity.	Proline	4-11	transcription factor AP-2 alpha	Homo sapiens	39-43
1464321-8	1992	The proline-rich activation domains of AP-2 and CTF/NF1 may represent a third class with considerable promoter activity and low but significant enhancer activity.	Proline	4-11	nuclear factor I B	Homo sapiens	48-51
1464321-8	1992	The proline-rich activation domains of AP-2 and CTF/NF1 may represent a third class with considerable promoter activity and low but significant enhancer activity.	Proline	4-11	neurofibromin 1	Homo sapiens	52-55
1284029-3	1992	The conceptual protein encoded by the xlan4 cDNA is 17.5% proline rich and possesses several PEST sequences found in proteins with short half-lives.	Proline	58-65	abl-interactor 2 S homeolog	Xenopus laevis	38-43
21554653-8	1992	The in vitro GH-releasing bioactivities of synthetic TRH and a milk extract purified in C(18) reversed-phase chromatography were abolished by proline-specific endopeptidase.	Proline	142-149	gonadotropin releasing hormone receptor	Rattus norvegicus	13-15
21554653-8	1992	The in vitro GH-releasing bioactivities of synthetic TRH and a milk extract purified in C(18) reversed-phase chromatography were abolished by proline-specific endopeptidase.	Proline	142-149	thyrotropin releasing hormone	Rattus norvegicus	53-56
1429549-1	1992	The Wilms" tumor locus on chromosome 11p13 contains a tumor suppressor gene, wt1, which encodes a DNA binding protein (WT1) with four zinc fingers and a glutamine-proline-rich N terminus and which functions as a repressor of transcription.	Proline	163-170	WT1 transcription factor	Homo sapiens	77-80
1332764-4	1992	The hydrophobic side chains of residues Leu(P4) and Pro(P2) reside on the same side of the peptide backbone as indicated by transferred NOEs and were found by modeling to fit into a hydrophobic cage around the thrombin active site.	Proline	52-55	coagulation factor II, thrombin	Bos taurus	210-218
1360645-3	1992	Outside the homeodomain, Prh, possesses an N-terminal region extremely rich in proline residues and a C-terminal acidic portion, either of which may function as transcription regulatory domains.	Proline	79-86	hematopoietically expressed homeobox	Mus musculus	25-28
1283051-4	1992	In EAU, ten peptide residues p1182-1191 of the IRBP amino acid sequence, were revealed to be sufficiently capable of lymphocyte activation for EAU, and it was also shown that amino acid positions 1182W (tryptophane), 1185G (glycine), 1186V (valine) and 1188P (proline) of IRBP play important roles as the epitopes or agretopes in developing EAU.	Proline	260-267	retinol binding protein 3, interstitial	Mus musculus	47-51
1283051-5	1992	On the other hand, two amino acids of IRBP, amino acid positions 1182W (tryptophane) and 1194P (proline) were shown to be the agretopes inducing autoimmune uveoretinitis in the TG nude mouse.	Proline	96-103	retinol binding protein 3, interstitial	Mus musculus	38-42
1453463-9	1992	In addition, CyP A is a closed beta-barrel so that neither the immunosuppressive drug cyclosporin A (CsA) nor the proline-containing substrate can bind to the hydrophobic core of the CyP A barrel, while the hydrophobic core of most other barrels is open for ligation.	Proline	114-121	peptidylprolyl isomerase A	Homo sapiens	13-18
1429606-1	1992	The primary sequence of the microtubule-associated protein tau contains multiple repeats of the sequence -X-Ser/Thr-Pro-X-, the consensus sequence for the proline-directed protein kinase (p34cdc2/p58cyclin A).	Proline	116-119	cyclin dependent kinase 1	Homo sapiens	188-195
1429549-1	1992	The Wilms" tumor locus on chromosome 11p13 contains a tumor suppressor gene, wt1, which encodes a DNA binding protein (WT1) with four zinc fingers and a glutamine-proline-rich N terminus and which functions as a repressor of transcription.	Proline	163-170	WT1 transcription factor	Homo sapiens	119-122
1444916-1	1992	Two members of a family with autosomal dominant retinitis pigmentosa were found to have a cytosine-to-thymine mutation in the second nucleotide of codon 267 in the rhodopsin gene that resulted in a proline-to-leucine change.	Proline	198-205	rhodopsin	Homo sapiens	164-173
1290451-3	1992	Haplotyping of 41 outbred CFW-Cr animals with a cDNA probe showed perfect cosegregation of Soa and Prp, a gene for salivary proline-rich proteins.	Proline	124-131	sucrose octaacetate aversion	Mus musculus	91-94
1290451-3	1992	Haplotyping of 41 outbred CFW-Cr animals with a cDNA probe showed perfect cosegregation of Soa and Prp, a gene for salivary proline-rich proteins.	Proline	124-131	proline rich protein HaeIII subfamily 1	Mus musculus	99-102
1443599-1	1992	The angiotensin I-based peptide Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Glu-Glu-Ser yields angiotensin I (Ang I) and Leu-Glu-Glu-Ser upon hydrolysis by the human immunodeficiency virus type 1 (HIV-1) protease, but not by human renin.	Proline	56-59	renin	Homo sapiens	231-236
1445249-6	1992	Human liver membranes also bound u-PA; binding was inhibited by pro-u-PA, the N-terminal fragment of u-PA, but not by the 33 kDa form of u-PA or by t-PA.	Proline	64-68	plasminogen activator, urokinase	Homo sapiens	33-37
1486864-9	1992	The p53 gene is a tumor-suppressor gene that can encode either a proline or an arginine in the 72nd residue.	Proline	65-72	tumor protein p53	Homo sapiens	4-7
1429840-15	1992	To examine the role of MPF kinase in the M-phase reorganization of vimentin we deleted the conserved proline of vimentin"s single MPF-kinase site; this mutation had no apparent effect on the prophase or M-phase behavior of vimentin.	Proline	101-108	vimentin L homeolog	Xenopus laevis	112-120
1429840-15	1992	To examine the role of MPF kinase in the M-phase reorganization of vimentin we deleted the conserved proline of vimentin"s single MPF-kinase site; this mutation had no apparent effect on the prophase or M-phase behavior of vimentin.	Proline	101-108	vimentin L homeolog	Xenopus laevis	112-120
1409579-1	1992	The mammalian shc gene encodes two overlapping proteins of 46 and 52 kDa, each with a C-terminal Src homology 2 (SH2) domain and an N-terminal glycine/proline-rich sequence, that induce malignant transformation when overexpressed in mouse fibroblasts.	Proline	151-158	SHC adaptor protein 1	Homo sapiens	14-17
1400449-2	1992	Previous work has shown that this mucin contains an extended tandem repeat-containing domain rich in Thr and Pro.	Proline	109-112	LOC100508689	Homo sapiens	34-39
1391960-6	1992	We report a second, common mutation that resulted from a T to C transition at nucleotide 905 and predicted a leucine to proline substitution at ASM codon 302 (designated L302P).	Proline	120-127	sphingomyelin phosphodiesterase 1	Homo sapiens	144-147
1419149-0	1992	Effect of insulin on the proline transport activity in cultured fibroblasts from patients with Werner syndrome.	Proline	25-32	insulin	Homo sapiens	10-17
1419149-1	1992	The effect of insulin on the transport of proline has been studied in cultured fibroblasts from normal individuals, non-insulin-dependent diabetic patients, and patients with Werner syndrome.	Proline	42-49	insulin	Homo sapiens	14-21
1437403-2	1992	The enzyme prolidase hydrolyzes dipeptides containing C-terminal proline or hydroxyproline.	Proline	65-72	peptidase D	Homo sapiens	11-20
1437403-5	1992	Our results indicate that prolidase plays a major role in the recycling of dipeptide-bound proline.	Proline	91-98	peptidase D	Homo sapiens	26-35
1477296-5	1992	The subsequent exons determine the functional domains of the hIL-5R alpha protein: the signal peptide, three fibronectin type III-like (FN-like) modules, each built up by two exons, the membrane anchor and two exons forming the cytoplasmic tail, the first of which contains the proline cluster region.	Proline	278-285	interleukin 5 receptor subunit alpha	Homo sapiens	61-73
1501886-2	1992	The N-terminal region of Tat is rich in proline and acidic residues analogous to the activation domains of other transcription factors such as GAL-4 and CTF/NF-1.	Proline	40-47	tyrosine aminotransferase	Homo sapiens	25-28
1508197-7	1992	They encode proline-rich polypeptides of 49.8 kDa (RSP4) and 48.8 kDa (RSP6), which are 48% identical to each other but do not resemble any previously sequenced proteins.	Proline	12-19	uncharacterized protein	Chlamydomonas reinhardtii	51-55
1508197-7	1992	They encode proline-rich polypeptides of 49.8 kDa (RSP4) and 48.8 kDa (RSP6), which are 48% identical to each other but do not resemble any previously sequenced proteins.	Proline	12-19	uncharacterized protein	Chlamydomonas reinhardtii	71-75
1336469-7	1992	beta globin gene analysis revealed a single nucleotide substitution, T-->C, at codon 91, which gives rise to a leucine-->proline substitution.	Proline	121-128	hemoglobin subunit beta	Homo sapiens	0-11
1335995-0	1992	Bradykinin and angiotensin II analogs containing a conformationally constrained proline analog.	Proline	80-87	kininogen 1	Homo sapiens	0-10
1335995-0	1992	Bradykinin and angiotensin II analogs containing a conformationally constrained proline analog.	Proline	80-87	angiotensinogen	Homo sapiens	15-29
1335995-1	1992	Three analogs of bradykinin and one of angiotensin II have been prepared in which the naturally occurring proline residues have been replaced by the bicyclic amino acid, 2,4-methanoproline (2,4-MePro).	Proline	106-113	kininogen 1	Homo sapiens	17-27
1335995-1	1992	Three analogs of bradykinin and one of angiotensin II have been prepared in which the naturally occurring proline residues have been replaced by the bicyclic amino acid, 2,4-methanoproline (2,4-MePro).	Proline	106-113	angiotensinogen	Homo sapiens	39-53
1450522-2	1992	The sequence -Thr-Pro-Ala-Pro-Lys-, as found in p53 protein, was also phosphorylated by this enzyme, but less efficiently than in the sequence described above.	Proline	18-21	tumor protein p53	Homo sapiens	48-51
1450522-2	1992	The sequence -Thr-Pro-Ala-Pro-Lys-, as found in p53 protein, was also phosphorylated by this enzyme, but less efficiently than in the sequence described above.	Proline	26-29	tumor protein p53	Homo sapiens	48-51
1510947-6	1992	Edman degradation of the two labeled peptides showed a single sequence His-Pro-Ile-([3H]X)-Arg corresponding to the pentapeptide His-Pro-Ile-Met-Arg 136-140 of SHBG sequence.	Proline	75-78	sex hormone binding globulin	Homo sapiens	160-164
1356808-0	1992	NMDA receptor-mediated depolarizing action of proline on CA1 pyramidal cells.	Proline	46-53	carbonic anhydrase 1	Homo sapiens	57-60
1512262-5	1992	In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1.	Proline	230-233	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	23-29
1512262-5	1992	In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1.	Proline	230-233	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	131-137
1509263-2	1992	In two unrelated Dutch families, a mutation in Pit-1 that altered an alanine in the first putative alpha helix of the POU-specific domain to proline was observed.	Proline	141-148	POU class 1 homeobox 1	Homo sapiens	47-52
1512232-7	1992	Fast atom bombardment mass spectrometry (FAB-MS) of proteolytic digests of SRF provides evidence for the presence of a single substoichiometric O-GlcNAc residue on each of four peptides isolated after sequential cyanogen bromide, tryptic, and proline specific enzyme digestion: these peptides are 306VSASVSP312, 274GTTSTIQTAP283, 313SAVSSADGTVLK324, and 374DSSTDLTQTSSSGTVTLP391.	Proline	243-250	serum response factor	Homo sapiens	75-78
1512232-7	1992	Fast atom bombardment mass spectrometry (FAB-MS) of proteolytic digests of SRF provides evidence for the presence of a single substoichiometric O-GlcNAc residue on each of four peptides isolated after sequential cyanogen bromide, tryptic, and proline specific enzyme digestion: these peptides are 306VSASVSP312, 274GTTSTIQTAP283, 313SAVSSADGTVLK324, and 374DSSTDLTQTSSSGTVTLP391.	Proline	243-250	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	144-152
1380835-0	1992	A serine, threonine and proline-rich region near the carboxyl-terminus of a rat intestinal mucin peptide.	Proline	24-31	solute carrier family 13 member 2	Rattus norvegicus	91-96
1380835-1	1992	Further sequencing of a cDNA encoding the C-terminal region of a rat intestinal mucin peptide reveals a region corresponding to 258 amino acids enriched in serine, threonine and proline, but no typical mucin-like tandem repeat structures.	Proline	178-185	solute carrier family 13 member 2	Rattus norvegicus	80-85
1324834-3	1992	Human coagulation factor XII is composed of the protease catalytic region at the C-terminus, a hinge proline-rich region and regulatory domains at the N-terminus.	Proline	101-108	coagulation factor XII	Homo sapiens	6-28
1502157-3	1992	In addition to six potential zinc fingers of the Cys2His2 type, MAZ contains an amino-terminal proline-rich domain and several polyalanine tracts.	Proline	95-102	MYC associated zinc finger protein	Homo sapiens	64-67
1356808-1	1992	This study investigated the actions of proline on CA1 hippocampal pyramidal cells with use of slice preparations.	Proline	39-46	carbonic anhydrase 1	Homo sapiens	50-53
1356808-4	1992	Grease-gap studies confirmed that L-proline depolarizes CA1 pyramidal cells.	Proline	34-43	carbonic anhydrase 1	Homo sapiens	56-59
1356808-8	1992	These results suggest that proline depolarized CA1 pyramidal cells mainly by activating postsynaptic NMDA receptors.	Proline	27-34	carbonic anhydrase 1	Homo sapiens	47-50
1352771-0	1992	Proline biosynthesis in Saccharomyces cerevisiae: analysis of the PRO3 gene, which encodes delta 1-pyrroline-5-carboxylate reductase.	Proline	0-7	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	66-70
1643041-0	1992	Role of proline residues in human lysozyme stability: a scanning calorimetric study combined with X-ray structure analysis of proline mutants.	Proline	8-15	lysozyme	Homo sapiens	34-42
1643041-0	1992	Role of proline residues in human lysozyme stability: a scanning calorimetric study combined with X-ray structure analysis of proline mutants.	Proline	126-133	lysozyme	Homo sapiens	34-42
1643041-9	1992	To clarify the role of specific proline residues in the thermostability of human lysozyme (h-lysozyme), a series of proline mutants were investigated by means of scanning calorimetry and high-resolution X-ray crystallography.	Proline	32-39	lysozyme	Homo sapiens	81-89
1643041-11	1992	h-Lysozyme contains two proline residues at positions 71 and 103.	Proline	24-31	lysozyme	Homo sapiens	2-10
1508147-0	1992	ore2, a mutation affecting proline biosynthesis in the yeast Saccharomyces cerevisiae, leads to a cdc phenotype.	Proline	27-34	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	0-4
1406699-0	1992	Pro-453 to Ser mutation in CYP21 is associated with nonclassic steroid 21-hydroxylase deficiency.	Proline	0-3	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	27-32
1508147-7	1992	The ore2 mutants, correspondingly, were found to be capable of growing at the non-permissive temperature on a synthetic medium supplemented with proline.	Proline	145-152	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	4-8
1496022-0	1992	Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs.	Proline	99-102	ribosomal protein S6 kinase B1	Rattus norvegicus	14-20
1379729-5	1992	The Lys-Ser-Pro domain is similar to that of mammalian medium NF (NF-M) and high NF (NF-H) proteins, where the serines are highly phosphorylated.	Proline	12-15	neurofilament medium chain	Homo sapiens	62-64
1379729-5	1992	The Lys-Ser-Pro domain is similar to that of mammalian medium NF (NF-M) and high NF (NF-H) proteins, where the serines are highly phosphorylated.	Proline	12-15	neurofilament medium chain	Homo sapiens	66-70
1379729-5	1992	The Lys-Ser-Pro domain is similar to that of mammalian medium NF (NF-M) and high NF (NF-H) proteins, where the serines are highly phosphorylated.	Proline	12-15	neurofilament medium chain	Homo sapiens	66-68
1379729-5	1992	The Lys-Ser-Pro domain is similar to that of mammalian medium NF (NF-M) and high NF (NF-H) proteins, where the serines are highly phosphorylated.	Proline	12-15	neurofilament medium chain	Homo sapiens	85-89
16669085-9	1992	The different locations of P5CR in root and leaf suggested that proline may be synthesized in different subcellular compartments in root and leaf.	Proline	64-71	pyrroline-5-carboxylate reductase	Glycine max	27-31
1352775-4	1992	In contrast to what occurs in dermal fibroblasts, IL-1 beta (5-20 units/ml) preferentially inhibited procollagen production as measured by [3H]proline incorporation.	Proline	143-150	interleukin 1 beta	Homo sapiens	50-59
1644173-0	1992	The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs.	Proline	95-98	microtubule associated protein tau	Homo sapiens	38-41
1644173-0	1992	The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs.	Proline	107-110	microtubule associated protein tau	Homo sapiens	38-41
1644173-4	1992	Here we show that the phosphorylation at Ser-Pro motifs strongly decreases tau"s affinity for microtubules.	Proline	45-48	microtubule associated protein tau	Homo sapiens	75-78
1632660-5	1992	The adherence of synovial cells to hyaluronidase treated cartilage slices in vitro was specifically inhibited by the synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro, which is the adhesive portion of the fibronectin molecule.	Proline	156-159	fibronectin 1	Homo sapiens	198-209
1633800-11	1992	The turtle antral peptide contains a Tyr followed by Pro as in chicken gastrin.	Proline	53-56	gastrin	Homo sapiens	71-78
1623525-2	1992	The SHC cDNA is predicted to encode overlapping proteins of 46.8 and 51.7 kd that contain a single C-terminal SH2 domain, and an adjacent glycine/proline-rich motif with regions of homology with the alpha 1 chain of collagen, but no identifiable catalytic domain.	Proline	146-153	SHC adaptor protein 1	Homo sapiens	4-7
1378434-3	1992	Of two naturally occurring variants in man that harbor single proline substitutions (TBG-CD5 and TBG-Montreal), only TBG-CD5 manifests as complete TBG deficiency.	Proline	62-69	serpin family A member 7	Homo sapiens	85-88
1378434-3	1992	Of two naturally occurring variants in man that harbor single proline substitutions (TBG-CD5 and TBG-Montreal), only TBG-CD5 manifests as complete TBG deficiency.	Proline	62-69	CD5 molecule	Homo sapiens	89-92
1378434-3	1992	Of two naturally occurring variants in man that harbor single proline substitutions (TBG-CD5 and TBG-Montreal), only TBG-CD5 manifests as complete TBG deficiency.	Proline	62-69	serpin family A member 7	Homo sapiens	97-100
1378434-3	1992	Of two naturally occurring variants in man that harbor single proline substitutions (TBG-CD5 and TBG-Montreal), only TBG-CD5 manifests as complete TBG deficiency.	Proline	62-69	serpin family A member 7	Homo sapiens	97-100
1631133-6	1992	The second peptide is identical to a form of GnRH originally isolated from chicken brains (chicken GnRH-II; pGlu-His-Trp-Ser-His-Gly-Trp-Tyr- Pro-Gly-NH2) and is widespread throughout the vertebrates.	Proline	142-145	mitochondrial ribosomal protein S26	Gallus gallus	99-106
1457964-6	1992	The IL-2-activated tyrosine kinase appears to be associated with a serine and proline rich intracellular domain which is highly conserved between IL-2R beta and the erythropoietin receptor.	Proline	78-85	interleukin 2	Homo sapiens	4-8
1355343-1	1992	Prolyl endopeptidase and dipeptidyl peptidase IV are serine proteases which cleave the peptide bonds at the carboxy group of proline residues.	Proline	125-132	prolyl endopeptidase	Homo sapiens	0-20
1355343-1	1992	Prolyl endopeptidase and dipeptidyl peptidase IV are serine proteases which cleave the peptide bonds at the carboxy group of proline residues.	Proline	125-132	dipeptidyl peptidase 4	Homo sapiens	25-48
1457964-6	1992	The IL-2-activated tyrosine kinase appears to be associated with a serine and proline rich intracellular domain which is highly conserved between IL-2R beta and the erythropoietin receptor.	Proline	78-85	interleukin 2 receptor subunit beta	Homo sapiens	146-156
1619012-6	1992	Previously, others have reported a kindred with GRTH, in that the same codon was subjected to proline to histidine replacement due to a mutation consisting of a cytosine to adenine replacement at nucleotide position 1643.	Proline	94-101	thyroid hormone receptor beta	Homo sapiens	48-52
1637938-8	1992	On the basis of putative cleavage sites on the SP-10 sequence, endoproteases that act at five different peptide bonds are predicted to cleave SP-10: these hydrolyze following arginine (a trypsin-like protease, possibly acrosin), and following serine, proline, glycine, and glutamic acid (previously undescribed intra-acrosomal protease specificities).	Proline	251-258	acrosomal vesicle protein 1	Homo sapiens	142-147
1358850-5	1992	The results demonstrate that N-Tyr-MIF-1 is in slow exchange between two conformers, most likely determined by the cis and trans states of the proline residue.	Proline	143-150	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	35-40
1377696-4	1992	Between the FNIII-like repeats and the plasma membrane spanning region neurofascin contains a domain 75-amino acid residues-long rich in proline, alanine and threonine which might be the target of extensive O-linked glycosylation.	Proline	137-144	neurofascin	Gallus gallus	71-82
1339352-9	1992	Moreover, since additional codons at the recombination site of V kappa and J kappa seem exceptional in expressed human kappa chains and because the resulting amino acid residue is a proline in most cases, we think that RF kappa chain CDR3 is under a very strong selective pressure during RA.	Proline	182-189	myelin regulatory factor	Mus musculus	219-221
1339352-9	1992	Moreover, since additional codons at the recombination site of V kappa and J kappa seem exceptional in expressed human kappa chains and because the resulting amino acid residue is a proline in most cases, we think that RF kappa chain CDR3 is under a very strong selective pressure during RA.	Proline	182-189	CDR3	Homo sapiens	234-238
1320004-0	1992	A Pro/Ser substitution in nucleoside diphosphate kinase of Drosophila melanogaster (mutation killer of prune) affects stability but not catalytic efficiency of the enzyme.	Proline	2-5	abnormal wing discs	Drosophila melanogaster	26-55
1434052-7	1992	Murine apolipoprotein AII is a serum precursor of murine senile amyloid protein, and the apolipoprotein AII variant with proline--&gt;glutamine substitution at position 5 in the serum of accelerated senescence-prone mice is identical to the murine senile amyloid fibril protein from amyloid-deposited tissues of these mice.	Proline	121-128	apolipoprotein A-II	Mus musculus	7-25
1434052-7	1992	Murine apolipoprotein AII is a serum precursor of murine senile amyloid protein, and the apolipoprotein AII variant with proline--&gt;glutamine substitution at position 5 in the serum of accelerated senescence-prone mice is identical to the murine senile amyloid fibril protein from amyloid-deposited tissues of these mice.	Proline	121-128	apolipoprotein A-II	Mus musculus	89-107
1610817-0	1992	Intramolecular catalysis of a proline isomerization reaction in the folding of dihydrofolate reductase.	Proline	30-37	Dihydrofolate reductase	Escherichia coli	79-102
1610817-3	1992	The guanidinium NH2 nitrogen of Arg 44 forms one hydrogen bond to the imide nitrogen and a second to the carbonyl oxygen of Pro 66 in wild-type DHFR.	Proline	124-127	Dihydrofolate reductase	Escherichia coli	144-148
1620551-1	1992	Mouse 10T1/2 cells were transfected with combinations of T24 H-ras, human c-myc and the proline 193 mutant form of p53.	Proline	88-95	tumor protein p53	Homo sapiens	115-118
1639922-5	1992	The synthetic peptides represented 1-3 multiple repeat units of the 5-residue sequence (Gly-His-His-Pro-His) found in the C-terminal of HRG.	Proline	100-103	histidine rich glycoprotein	Homo sapiens	136-139
1376918-12	1992	The phosphorylatable serines detected by the SMI antibodies are part of Ser-Pro motifs and can be phosphorylated by a protein kinase activity that can be used to induce a paired helical filament-like state in human brain tau in vitro.	Proline	76-79	microtubule associated protein tau	Homo sapiens	221-224
1350780-0	1992	Proline biosynthesis in Saccharomyces cerevisiae: molecular analysis of the PRO1 gene, which encodes gamma-glutamyl kinase.	Proline	0-7	glutamate 5-kinase	Saccharomyces cerevisiae S288C	76-80
1606144-7	1992	The pro-S oxygen atom of the two phosphonate inhibitors and of the phosphinate group of the StaP inhibitor make very short contact distances (approximately 2.4 A) to the carboxyl oxygen atom, O delta 1, of Asp33 on penicillopepsin.	Proline	4-9	cytoglobin	Homo sapiens	92-96
1376245-6	1992	It is capable of phosphorylating Ser-Pro and Thr-Pro motifs in tau protein (approximately 14-16 P1 per tau molecule).	Proline	37-40	microtubule associated protein tau	Homo sapiens	63-66
1376245-6	1992	It is capable of phosphorylating Ser-Pro and Thr-Pro motifs in tau protein (approximately 14-16 P1 per tau molecule).	Proline	37-40	microtubule associated protein tau	Homo sapiens	103-106
1376245-6	1992	It is capable of phosphorylating Ser-Pro and Thr-Pro motifs in tau protein (approximately 14-16 P1 per tau molecule).	Proline	49-52	microtubule associated protein tau	Homo sapiens	63-66
1376245-6	1992	It is capable of phosphorylating Ser-Pro and Thr-Pro motifs in tau protein (approximately 14-16 P1 per tau molecule).	Proline	49-52	microtubule associated protein tau	Homo sapiens	103-106
1376245-7	1992	By contrast, other proline directed Ser/Thr kinases such as p34(cdc2) combined with cyclin A or B have only minor effects on tau phosphorylation.	Proline	19-26	leucine rich repeat containing 59	Homo sapiens	60-63
1376245-7	1992	By contrast, other proline directed Ser/Thr kinases such as p34(cdc2) combined with cyclin A or B have only minor effects on tau phosphorylation.	Proline	19-26	cyclin dependent kinase 1	Homo sapiens	64-68
1376245-7	1992	By contrast, other proline directed Ser/Thr kinases such as p34(cdc2) combined with cyclin A or B have only minor effects on tau phosphorylation.	Proline	19-26	microtubule associated protein tau	Homo sapiens	125-128
1601037-3	1992	CD46 cDNA encodes four extracellular short consensus repeat domains, a Ser/Thr/Pro (STP)-rich region, a transmembrane region and a cytoplasmic tail.	Proline	79-82	CD46 molecule	Homo sapiens	0-4
1592829-0	1992	Proline biosynthesis in Saccharomyces cerevisiae: analysis of the PRO3 gene, which encodes delta 1-pyrroline-5-carboxylate reductase.	Proline	0-7	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	66-70
1592829-1	1992	The PRO3 gene of Saccharomyces cerevisiae encodes the 286-amino-acid protein delta 1-pyrroline-5-carboxylate reductase [L-proline:NAD(P+) 5-oxidoreductase; EC 1.5.1.2], which catalyzes the final step in proline biosynthesis.	Proline	122-129	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	4-8
1525706-1	1992	Previous studies of human statherin showed the active region for inhibition of secondary calcium phosphate precipitation (crystal growth) to reside in the highly charged amino-terminal one-third of this molecule, and the neutral tyrosine-, glutamine- and proline-rich carboxy-terminal two-thirds of the molecule is required for maximal inhibition of primary (spontaneous) precipitation.	Proline	255-262	statherin	Homo sapiens	26-35
1376267-5	1992	We attribute the failure of Sendai octamer binding to the presence of proline in position two: replacement of proline renders the resulting octamers as efficient as FAPGNYPAL for binding and stabilization of H-2 Kb.	Proline	110-117	relaxin 2	Homo sapiens	208-211
1350780-1	1992	The PRO1 gene of Saccharomyces cerevisiae encodes the 428-amino-acid protein gamma-glutamyl kinase (ATP:L-glutamate 5-phosphotransferase, EC 2.7.2.11), which catalyzes the first step in proline biosynthesis.	Proline	186-193	glutamate 5-kinase	Saccharomyces cerevisiae S288C	4-8
1350780-5	1992	PRO1 expression was not repressed by exogenous proline and was not induced by the presence of glutamate in the growth medium.	Proline	47-54	glutamate 5-kinase	Saccharomyces cerevisiae S288C	0-4
1350780-7	1992	In addition, a pro1 bradytrophic strain became completely auxotrophic for proline in a gcn4 strain background.	Proline	74-81	glutamate 5-kinase	Saccharomyces cerevisiae S288C	15-19
1350780-7	1992	In addition, a pro1 bradytrophic strain became completely auxotrophic for proline in a gcn4 strain background.	Proline	74-81	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	87-91
1577789-7	1992	However, the Arg-Gly-Asp-containing synthetic peptide Gly-Arg-Gly-Asp-Ser-Pro significantly inhibited cell attachment to MGP, whereas the control peptide Gly-Arg-Gly-Glu-Ser-Pro had minimal effect.	Proline	74-77	matrix Gla protein	Bos taurus	121-124
1392014-5	1992	Our previous hypothesis that the Val-Tyr-Ile-His-Pro fragment of angiotensin II is responsible for the psychotropic activity evoked by angiotensins in rats is thus confirmed.	Proline	49-52	angiotensinogen	Rattus norvegicus	65-79
1524216-3	1992	The hydrolysis of Abz-His-Pro-Phe-His-Leu-Val-Ile-His-EDDnp by human renin was inhibited by a highly specific transition-state analog of angiotensinogen (IC50 = 7.8 x 10(-9) M), described by K. Iizuka et al.	Proline	26-29	renin	Homo sapiens	69-74
1524216-3	1992	The hydrolysis of Abz-His-Pro-Phe-His-Leu-Val-Ile-His-EDDnp by human renin was inhibited by a highly specific transition-state analog of angiotensinogen (IC50 = 7.8 x 10(-9) M), described by K. Iizuka et al.	Proline	26-29	angiotensinogen	Homo sapiens	137-152
16668921-5	1992	The larger extensin reported earlier lacked the Ser-Hyp(4) motif, was rich in proline and hydroxyproline, and contained peptide motifs similar to the dicot repetitive proline-rich proteins.	Proline	78-85	extensin-3-like	Solanum lycopersicum	11-19
16668921-5	1992	The larger extensin reported earlier lacked the Ser-Hyp(4) motif, was rich in proline and hydroxyproline, and contained peptide motifs similar to the dicot repetitive proline-rich proteins.	Proline	97-104	extensin-3-like	Solanum lycopersicum	11-19
1590775-2	1992	Peptidyldiazomethanes with proline in the P1 position were found to be competitive slow-binding inhibitors of prolyl endopeptidase.	Proline	27-34	prolyl endopeptidase	Homo sapiens	110-130
1374899-4	1992	Furthermore, we have found a second point mutation in the Pmp-22 gene of trembler-J (TrJ) mice, which results in the substitution of a leucine residue by a proline residue in the putative first transmembrane region of the PMP-22 polypeptide.	Proline	156-163	peripheral myelin protein 22	Mus musculus	58-64
1374899-4	1992	Furthermore, we have found a second point mutation in the Pmp-22 gene of trembler-J (TrJ) mice, which results in the substitution of a leucine residue by a proline residue in the putative first transmembrane region of the PMP-22 polypeptide.	Proline	156-163	peripheral myelin protein 22	Mus musculus	222-228
1290488-1	1992	Hirulog-1 [D-Phe-Pro-Arg-Pro-[Gly]4-desulphohirudin-(53-64) (HV1)] was designed to bind by its first four and last 12 residues to the alpha-thrombin catalytic site and anion-binding exosite for fibrin(ogen) recognition respectively, with a [Gly]4 bridge and an Arg-Pro bond at the scissional position.	Proline	17-20	coagulation factor II, thrombin	Homo sapiens	140-148
1314591-1	1992	Analogs of thyrotropin-releasing hormone (Glp-His-Pro-NH2, TRH) have been prepared which contain thioamide moieties in the pyroglutamic acid ring, the carboxyamide proline terminus, and in both positions (dithio).	Proline	164-171	thyrotropin releasing hormone	Rattus norvegicus	11-40
1373816-7	1992	The other PTPase, PEP (proline-, glutamic acid-, serine-, and threonine-rich [PEST]-domain phosphatase), is distinguished by virtue of a large carboxy-terminal domain of approximately 500 amino acids that is rich in PEST residues.	Proline	23-30	prolyl endopeptidase	Mus musculus	18-21
1314591-1	1992	Analogs of thyrotropin-releasing hormone (Glp-His-Pro-NH2, TRH) have been prepared which contain thioamide moieties in the pyroglutamic acid ring, the carboxyamide proline terminus, and in both positions (dithio).	Proline	50-53	thyrotropin releasing hormone	Rattus norvegicus	11-40
1601289-2	1992	The IgA1 hinge is 18 amino acids long and contains only proline, threonine and serine.	Proline	56-63	immunoglobulin heavy constant alpha 1	Homo sapiens	4-8
1374027-3	1992	Two mutants (Ser29 substituted by Arg-Leu-Pro-Gly, and Ser33 substituted by Cys-Gly-Asp) represent two naturally occurring variants of IGF II.	Proline	42-45	insulin like growth factor 2	Homo sapiens	135-141
1631793-1	1992	rt-PA P47G, K49N, a substitution variant of recombinant human tissue-type plasminogen activator (rt-PA), in which proline at position 47 and lysine at position 49 were replaced by glycine and asparagine respectively, was previously described by Ahern et al.	Proline	114-121	plasminogen activator, tissue type	Homo sapiens	62-95
1451779-5	1992	The individual substitutions of Pro-5 and Lys-7 in the latter peptide with Gly and Ala (or Glu), respectively, prevent its phosphorylation by cdc2, whereas the substitution of Lys-3 with Ala is well tolerated and the substitution of the target Ser with Thr actually improves phosphorylation.	Proline	32-35	cyclin dependent kinase 1	Homo sapiens	142-146
1565618-6	1992	A striking feature of syndecan 3 is an extensive (182 amino acid) threonine, serine, and proline (T+S+P)-rich domain that closely resembles T+S+P-rich regions in several mucin-like proteins in which O-linked oligosaccharides are bound to the threonine and serine residues.	Proline	89-96	syndecan 3	Gallus gallus	22-32
1591884-3	1992	PPIase, which catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, has recently been found to be identical to cyclophilin, a specific binding protein of a potent immunosuppressant, cyclosporin A.	Proline	55-62	peptidylprolyl isomerase like 1	Homo sapiens	0-6
1550123-8	1992	Proband 2 was heteroallelic, having a T-to-C transition in nt 707, which predicted a leucine-to-proline replacement at ASB residue 236 (L236P), and having a G-to-A transition in nt 1214, which predicted a cysteine-to-tyrosine substitution at ASB residue 405 (C405Y).	Proline	96-103	arylsulfatase B	Homo sapiens	119-122
1591884-3	1992	PPIase, which catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, has recently been found to be identical to cyclophilin, a specific binding protein of a potent immunosuppressant, cyclosporin A.	Proline	55-62	peptidylprolyl isomerase like 1	Homo sapiens	145-156
1587342-6	1992	At this time, an increased lung collagen synthesis, assessed by determining prolyl hydroxylase activity and incorporation of radiolabeled proline, was found in Tsk mice with respect to control mice.	Proline	138-145	fibrillin 1	Mus musculus	160-163
1563344-10	1992	The N-terminal domain of GBF1 is defined by a high proline content.	Proline	51-58	G-box binding factor 1	Arabidopsis thaliana	25-29
1563344-12	1992	We demonstrate that this N-terminal proline-rich domain of GBF1, when fused to a heterologous DNA binding domain, stimulates transcription in both plant protoplasts and mammalian cells.	Proline	36-43	golgi brefeldin A resistant guanine nucleotide exchange factor 1	Homo sapiens	59-63
1563356-0	1992	The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.	Proline	96-103	microtubule associated protein tau	Homo sapiens	14-17
1569926-2	1992	The Y1 receptor-specific agonist (Leu-31,Pro-34)-NPY is 4-fold more potent and the carboxyl-terminal fragment NPY13-36 is 150-fold less potent than NPY.	Proline	41-44	neuropeptide Y	Homo sapiens	49-52
1378874-0	1992	Characterization of monoclonal antibody 436 recognizing the Arg-Pro-Ala-Pro sequence of the polymorphic epithelial mucin (PEM) protein core in breast carcinoma cells.	Proline	64-67	mucin 1, cell surface associated	Homo sapiens	92-120
1378874-0	1992	Characterization of monoclonal antibody 436 recognizing the Arg-Pro-Ala-Pro sequence of the polymorphic epithelial mucin (PEM) protein core in breast carcinoma cells.	Proline	64-67	mucin 1, cell surface associated	Homo sapiens	122-125
1498600-1	1992	A gene from maize that encodes a hybrid proline-rich protein (HyPRP) formed by two well-defined domains, proline-rich and hydrophobic, respectively, has been characterized at the level of its structure and expression.	Proline	40-47	uncharacterized protein LOC100283347	Zea mays	62-67
1304349-4	1992	The crystallographic refinement of the PPACK-thrombin model has now been completed at an R value of 0.156 (8 to 1.92 A); in particular, the amino- and the carboxy-termini of the thrombin A-chain are now defined and all side-chain atoms localized; only proline 37 was found to be in a cis-peptidyl conformation.	Proline	252-259	coagulation factor II, thrombin	Homo sapiens	178-186
1565471-7	1992	This results in the translation of a 72 kDa protein, compared with the 120 kDa protein encoded by full-length c-cbl, which lacks a portion of the proline-rich domain and the entire leucine zipper.	Proline	146-153	Cbl proto-oncogene	Homo sapiens	110-115
1371999-13	1992	Further sequencing of MLP 2677 in a direction 5" to the codon specifying the NH2-terminal proline of the link has revealed a coding region for 148 amino acids, including a unique 75-amino acid domain rich in cysteine and proline, and a region containing 4.5-variable tandem repeats (each 11-12 amino acids) rich in serine, threonine, and proline.	Proline	221-228	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	22-25
1320881-5	1992	The beta-casomorphins, beta-casein derived opioid peptides, with a proline residue at their C-terminus also showed inhibitory action on ACE activity, without being cleaved by the enzyme.	Proline	67-74	angiotensin I converting enzyme	Homo sapiens	136-139
1547237-6	1992	The global folding of these conformations is similar to that in the thrombin-bound state, as indicated by NOE"s involving the side-chain protons of residues Phe(56), Ile(59), Pro(60), Tyr(63), and Leu(64).	Proline	175-178	coagulation factor II, thrombin	Homo sapiens	68-76
1371999-13	1992	Further sequencing of MLP 2677 in a direction 5" to the codon specifying the NH2-terminal proline of the link has revealed a coding region for 148 amino acids, including a unique 75-amino acid domain rich in cysteine and proline, and a region containing 4.5-variable tandem repeats (each 11-12 amino acids) rich in serine, threonine, and proline.	Proline	90-97	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	22-25
1371999-13	1992	Further sequencing of MLP 2677 in a direction 5" to the codon specifying the NH2-terminal proline of the link has revealed a coding region for 148 amino acids, including a unique 75-amino acid domain rich in cysteine and proline, and a region containing 4.5-variable tandem repeats (each 11-12 amino acids) rich in serine, threonine, and proline.	Proline	221-228	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	22-25
1547276-8	1992	The decreased binding of the peptides with Pro-219 substitutes suggests that the confirmation of GPIIIa 217-230 is important for its ability to bind to adhesive ligands.	Proline	43-46	integrin subunit beta 3	Homo sapiens	97-103
1547276-9	1992	In conclusion, the amino acid residues between 217 and 231 of GPIIIa appear to be involved in ligand binding and Pro-219 probably plays a significant role in this interaction.	Proline	113-116	integrin subunit beta 3	Homo sapiens	62-68
1339347-7	1992	The composite MP5 cDNA was 897 nucleotides long and contained an open reading frame capable of encoding a 260-residue-long salivary PRP precursor (30% Pro, 19% Gln and 18% Gly), containing nine variant repeat units of consensus PGNQQGPPPQGGPQQ(GPP)R(PPQ).	Proline	151-154	proline-rich protein MP5	Mus musculus	14-17
1421205-0	1992	Effects of dexamethasone on TRH and TRH precursor peptide (Lys-Arg-Gln-His-Pro-Gly-Arg-Arg) levels in various rat organs.	Proline	75-78	thyrotropin releasing hormone	Rattus norvegicus	36-39
1421205-1	1992	The effect of an acute dexamethasone administration on thyrotropin-releasing hormone (TRH) and TRH precursor peptide (Lys-Arg-Gln-His-Pro-Gly-Arg-Arg) (p-8) levels in various rat organs has been studied.	Proline	134-137	thyrotropin releasing hormone	Rattus norvegicus	95-98
1339347-7	1992	The composite MP5 cDNA was 897 nucleotides long and contained an open reading frame capable of encoding a 260-residue-long salivary PRP precursor (30% Pro, 19% Gln and 18% Gly), containing nine variant repeat units of consensus PGNQQGPPPQGGPQQ(GPP)R(PPQ).	Proline	151-154	proline rich protein HaeIII subfamily 1	Mus musculus	132-135
1310675-0	1992	Glyconeogenesis from L-proline involves metabolite inhibition of the glucose-6-phosphatase system.	Proline	21-30	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	69-90
1737788-7	1992	Although the tryptic 32P-peptides bearing the cdc2 and erk/MAP kinase phosphorylation sites co-migrate with a subset of the sites phosphorylated in situ in insulin-stimulated cells, phosphorylation of the p70 S6 kinase by these proline-directed protein kinases in vitro does not reproducibly activate p70 S6 kinase activity.	Proline	228-235	cyclin-dependent kinase 1	Rattus norvegicus	46-50
1737788-7	1992	Although the tryptic 32P-peptides bearing the cdc2 and erk/MAP kinase phosphorylation sites co-migrate with a subset of the sites phosphorylated in situ in insulin-stimulated cells, phosphorylation of the p70 S6 kinase by these proline-directed protein kinases in vitro does not reproducibly activate p70 S6 kinase activity.	Proline	228-235	Eph receptor B1	Rattus norvegicus	55-58
1561009-1	1992	Histidine-rich glycoprotein (HRG) is a 74-kD glycoprotein, originally discovered in plasma, which contains an unusually large amount of histidine (13 mol%) and proline (13 mol%).	Proline	160-167	histidine rich glycoprotein	Homo sapiens	0-27
1561009-1	1992	Histidine-rich glycoprotein (HRG) is a 74-kD glycoprotein, originally discovered in plasma, which contains an unusually large amount of histidine (13 mol%) and proline (13 mol%).	Proline	160-167	histidine rich glycoprotein	Homo sapiens	29-32
1540646-8	1992	Hydrolysis of the substrate was strongly inhibited by bradykinin and those of its lower homologs that contain two adjacent proline residues.	Proline	123-130	kininogen 1	Homo sapiens	54-64
1737788-3	1992	Although distinguishable in their substrate specificity, these protein kinases together with the p54 MAP-2 kinase share a major common specificity determinant reflected in the SKAIPS peptide: the requirement for a proline residue immediately carboxyl-terminal to the site of Ser/Thr phosphorylation.	Proline	214-221	nucleobindin 2	Rattus norvegicus	97-100
1737788-3	1992	Although distinguishable in their substrate specificity, these protein kinases together with the p54 MAP-2 kinase share a major common specificity determinant reflected in the SKAIPS peptide: the requirement for a proline residue immediately carboxyl-terminal to the site of Ser/Thr phosphorylation.	Proline	214-221	microtubule-associated protein 2	Rattus norvegicus	101-106
1378653-3	1992	It was predicted to be immunogenic because a Hopp-Woods hydrophilicity analysis of the amino acid sequence of FVIII showed it to be very hydrophilic, and it contained a proline.	Proline	169-176	coagulation factor VIII	Homo sapiens	110-115
1737852-7	1992	The other two nonhereditary p53 mutations included a T to G transversion at codon 270 (phenylalanine to cysteine) and a G to C transversion at codon 248 (arginine to proline).	Proline	166-173	tumor protein p53	Homo sapiens	28-31
1540182-2	1992	The [3H] proline incorporation into the collagenase digestible protein(CDP) and the percent collagen synthesis were significantly decreased in the c-fos transfectants which constitutively express c-fos mRNA as compared with control transfectants.	Proline	9-16	cut-like homeobox 1	Mus musculus	71-74
1540182-2	1992	The [3H] proline incorporation into the collagenase digestible protein(CDP) and the percent collagen synthesis were significantly decreased in the c-fos transfectants which constitutively express c-fos mRNA as compared with control transfectants.	Proline	9-16	FBJ osteosarcoma oncogene	Mus musculus	147-152
1540182-2	1992	The [3H] proline incorporation into the collagenase digestible protein(CDP) and the percent collagen synthesis were significantly decreased in the c-fos transfectants which constitutively express c-fos mRNA as compared with control transfectants.	Proline	9-16	FBJ osteosarcoma oncogene	Mus musculus	196-201
1542107-0	1992	Proline cis-trans isomers in calbindin D9k observed by X-ray crystallography.	Proline	0-7	S100 calcium binding protein G	Bos taurus	29-42
1542107-1	1992	In a structure of recombinant bovine calbindin D9k, determined crystallographically to 1.6 A resolution, a proline in mixed, approximately equally populated, cis and trans conformation is observed.	Proline	107-114	S100 calcium binding protein G	Bos taurus	37-50
1318546-7	1992	Apo[a] kringles are linked by serine/threonine- and proline-rich stretches similar to regions in immunoglobulins, adhesion molecules, glycoprotein Ib-alpha subunit, and kininogen.	Proline	52-59	lipoprotein(a)	Homo sapiens	0-5
1292892-6	1992	The IMP-L1 gene encodes a novel protein product containing a signal peptide, a possible transmembrane domain, two highly charged domains and a proline rich C-terminal domain.	Proline	143-150	Ecdysone-inducible gene L1	Drosophila melanogaster	4-10
1730675-1	1992	Pyrroline-5-carboxylate reductase (EC 1.5.1.2) catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline.	Proline	120-127	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	0-33
1730675-2	1992	We cloned a human pyrroline-5-carboxylate reductase cDNA by complementation of proline auxotrophy in a Saccharomyces cerevisiae mutant strain, DT1100.	Proline	79-86	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	18-51
1359725-3	1992	For comparison, we also examined 7 patients with Gerstmann-Straussler syndrome (GSS) with a proline-to-leucine change at PrP codon 102 (GSS102 patients) and 13 patients without any known mutations at codons 102, 117, 129, 178, or 200 (CJDwild patients).	Proline	92-99	prion protein	Homo sapiens	121-124
1361094-0	1992	Proline-specific aminopeptidases: potential role in bradykinin degradation.	Proline	0-7	kininogen 1	Homo sapiens	52-62
1361094-1	1992	The N-terminus of bradykinin is shown to be sequentially degraded by the human proline-specific aminopeptidases aminopeptidase P (EC 3.4.11.9) and dipeptidyl peptidase IV (EC 3.4.14.5).	Proline	79-86	kininogen 1	Homo sapiens	18-28
1361094-1	1992	The N-terminus of bradykinin is shown to be sequentially degraded by the human proline-specific aminopeptidases aminopeptidase P (EC 3.4.11.9) and dipeptidyl peptidase IV (EC 3.4.14.5).	Proline	79-86	dipeptidyl peptidase 4	Homo sapiens	147-170
1310882-7	1992	Furthermore, PTH depressed collagen synthesis as measured by [3H]-proline incorporation.	Proline	66-73	parathyroid hormone	Gallus gallus	13-16
1466239-2	1992	Autoradiographic studies of 3H-proline labeling over bone matrix indicated that 24 h after treatment on day 11, FGF stimulated osteogenic cell proliferation, while inhibiting the production of bone matrix collagen.	Proline	31-38	fibroblast growth factor 10	Gallus gallus	112-115
1477634-0	1992	Diffuse loss of rod function in autosomal dominant retinitis pigmentosa with pro-347-leu mutation of rhodopsin.	Proline	77-80	rhodopsin	Homo sapiens	101-110
1627827-5	1992	The sequence shows a 61% identity with mouse calreticulin, increasing to 82% in the proline-rich region of the molecule.	Proline	84-91	calreticulin	Mus musculus	45-57
1739433-7	1992	Finally, predictions of the structure of mouse I-FABP using the refined 2.0 A model of rat I-FABP, suggest that a proline found at position 69 of the mouse, but not rat, protein may affect its ligand binding properties.	Proline	114-121	fatty acid binding protein 2, intestinal	Mus musculus	47-53
1739433-7	1992	Finally, predictions of the structure of mouse I-FABP using the refined 2.0 A model of rat I-FABP, suggest that a proline found at position 69 of the mouse, but not rat, protein may affect its ligand binding properties.	Proline	114-121	fatty acid binding protein 2	Rattus norvegicus	91-97
1576975-1	1992	Daily subcutaneous injections of rat derived growth hormone to immature, hypophysectomized rats stimulated significant increases in body weight gain, serum osteocalcin, skeletal alkaline phosphatase and incorporation of radioactive thymidine and proline into the compact bone of femurs and tibiae.	Proline	246-253	gonadotropin releasing hormone receptor	Rattus norvegicus	45-59
1477634-5	1992	All displayed the same rhodopsin gene mutation at codon 347, which exchanges the amino acid proline for leucine (pro-347-leu).	Proline	92-99	rhodopsin	Homo sapiens	23-32
1477634-5	1992	All displayed the same rhodopsin gene mutation at codon 347, which exchanges the amino acid proline for leucine (pro-347-leu).	Proline	92-95	rhodopsin	Homo sapiens	23-32
1729602-10	1992	Changing the penultimate proline codon 3" to UUG at his4 to a Phe codon (UUC) blocks aminopeptidase cleavage of the amino-terminal amino acid of the His4-beta-galactosidase protein, as noted by the appearance of Met in the first cycle of the Edman degradation reaction.	Proline	25-32	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	52-56
1301199-5	1992	The T-C change at position 114 of the beta-globin gene results in a leucine to proline substitution (Leu-Pro) in the G-helix.	Proline	79-86	hemoglobin subunit beta	Homo sapiens	38-49
1371492-4	1992	We used the peptide Trp-Thr-Val-Pro-Thr-Ala, WTVPTA (deduced from the complementary nucleotide sequence to that which codes for the Arg-Gly-Asp, RGD, domain in fibronectin), to test the immunologic activity of ITP sera.	Proline	32-36	fibronectin 1	Homo sapiens	160-171
1527992-0	1992	Diminished concentration of the NF-H subunit of neurofilaments in cerebral cortex of rats chronically treated with proline, methylmalonate and phenylalanine plus alpha-methylphenylalanine.	Proline	115-122	neurofilament heavy chain	Rattus norvegicus	32-36
1735701-6	1992	All of the ACE inhibitors are analogues of proline.	Proline	43-50	angiotensin I converting enzyme	Rattus norvegicus	11-14
1729602-10	1992	Changing the penultimate proline codon 3" to UUG at his4 to a Phe codon (UUC) blocks aminopeptidase cleavage of the amino-terminal amino acid of the His4-beta-galactosidase protein, as noted by the appearance of Met in the first cycle of the Edman degradation reaction.	Proline	25-32	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	149-153
1765098-8	1991	The peptide was named PR-39 (proline-arginine-rich with a size of 39 residues).	Proline	29-36	antibacterial protein PR-39	Sus scrofa	22-27
1765104-3	1991	This gene (MP4) contained three introns and encoded a 1020-nt (nt, nucleotide) mRNA for a PRP precursor 300 amino acids long arranged with 11 imperfect 18-residue proline-rich repeats.	Proline	163-170	predicted gene 4736	Mus musculus	11-14
1813101-2	1991	Purified germ-free rat intestinal mucin was found by chemical analysis to contain 25% protein, enriched in serine, threonine, and proline, 75% carbohydrate, and no nucleic acid.	Proline	130-137	solute carrier family 13 member 2	Rattus norvegicus	34-39
1748630-2	1991	Growth factor stimulation of cells causes the phosphorylation of the c-Myc transcriptional activation domain at Ser62 within a proline-rich region that is highly conserved among members of the Myc family (Alvarez, E., Northwood, I.C., Gonzalez, F. A., Latour, D. A., Seth, A., Abate, C., Curran, T., and Davis, R. J.	Proline	127-134	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	69-74
1684935-2	1991	In Escherichia coli, an aldehyde dehydrogenase that catalyzes the oxidation of L-lactaldehyde to L-lactate is induced not only by L-fucose, L-rhamnose or D-arabinose, but also by growth in the presence of glutamate or amino acids yielding glutamate, with the exception of proline.	Proline	272-279	Aldehyde dehydrogenase	Escherichia coli	24-46
1748630-2	1991	Growth factor stimulation of cells causes the phosphorylation of the c-Myc transcriptional activation domain at Ser62 within a proline-rich region that is highly conserved among members of the Myc family (Alvarez, E., Northwood, I.C., Gonzalez, F. A., Latour, D. A., Seth, A., Abate, C., Curran, T., and Davis, R. J.	Proline	127-134	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	71-74
1748683-9	1991	The conserved proline residue of RAD6 and CDC34 is part of a turn motif common to all ubiquitin-conjugating enzymes.	Proline	14-21	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	33-37
1801928-5	1991	Nucleotide sequencing of the corresponding cDNAs revealed that these two forms of lyn mRNA differ in the presence and absence of a 63 nucleotides sequence near the 5"-terminus of the coding region; 21 amino acid residues (Pro-23 to Arg-43 or Val-24 to Pro-44) of p56lyn were tentatively concluded to be missing in p53lyn.	Proline	222-225	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
1748683-9	1991	The conserved proline residue of RAD6 and CDC34 is part of a turn motif common to all ubiquitin-conjugating enzymes.	Proline	14-21	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	42-47
1822238-5	1991	These methods were used in a study of O-GlcNAc glycopeptides produced by purified O-GlcNAc transferase addition of GlcNAc to the synthetic peptides YSDSPSTST and YSGSPSTST in which Y is tyrosine, S is serine, D is aspartic acid, P is proline, T is threonine and G is glycine.	Proline	234-241	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	38-46
1748279-2	1991	Here, we report the isolation of coactivators responsible for mediating transcriptional activation by Gal4-Pro, a hybrid regulator containing the proline-rich activation domain of human CTF/NFI.	Proline	146-153	galectin 4	Homo sapiens	102-106
1748279-2	1991	Here, we report the isolation of coactivators responsible for mediating transcriptional activation by Gal4-Pro, a hybrid regulator containing the proline-rich activation domain of human CTF/NFI.	Proline	146-153	nuclear factor I C	Homo sapiens	186-193
1718739-3	1991	The putative protein encoded by pax[zf-a] contains a paired box and a paired-type homeobox separated by a glycine-rich, acidic linker and a carboxy-terminal end which is remarkably rich in serine, threonine and proline residues.	Proline	211-218	paired box 6a	Danio rerio	32-40
1822238-5	1991	These methods were used in a study of O-GlcNAc glycopeptides produced by purified O-GlcNAc transferase addition of GlcNAc to the synthetic peptides YSDSPSTST and YSGSPSTST in which Y is tyrosine, S is serine, D is aspartic acid, P is proline, T is threonine and G is glycine.	Proline	234-241	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	82-90
1687809-10	1991	A 168 bp insertion which codes for 56 amino acids corresponding to 7 extra uninterrupted repeats of proline-glycine rich octapeptide (PHGGGWGQ) was detected in the N terminal region of PrP gene.	Proline	100-107	prion protein	Homo sapiens	185-188
1819586-3	1991	In the dipeptide esters, Boc-Aib-Ac7c-OMe and Boc-Pro-Ac7c-OMe, the Ac7c and Aib residues adopt helical conformations, while the Pro residue remains semi-extended in both the molecules of Boc-Pro-Ac7c-OMe found in the asymmetric unit.	Proline	50-53	ANIB1	Homo sapiens	77-80
1836471-4	1991	By contrast, plasmin generation by pro-UK or by Ala-158-pro-UK was not promoted either by fibrinogen, Desafib, or FCB-2, but was significantly promoted by fragment E-2.	Proline	35-38	plasminogen	Homo sapiens	13-20
1719231-9	1991	Amino acid residues of ICAM-1 showing the greatest effect on virus and antibody binding included Pro-28, Lys-29, Leu-30, Leu-37, Lys-40, Ser-67, and Pro-70.	Proline	97-100	intercellular adhesion molecule 1	Homo sapiens	23-29
1719231-9	1991	Amino acid residues of ICAM-1 showing the greatest effect on virus and antibody binding included Pro-28, Lys-29, Leu-30, Leu-37, Lys-40, Ser-67, and Pro-70.	Proline	149-152	intercellular adhesion molecule 1	Homo sapiens	23-29
1944290-8	1991	The inferred RPD1 protein contains four regions predicted to take on helix-loop-helix-like secondary structures and three regions (acidic, glutamine rich, and proline rich) reminiscent of the activating domains of transcriptional activators.	Proline	159-166	transcriptional regulator SIN3	Saccharomyces cerevisiae S288C	13-17
1720261-2	1991	In one family studied, inheritance of EBS is linked to the gene encoding keratin 14, and a thymine to cytosine mutation in exon 6 of keratin 14 has introduced a proline in the middle of an alpha-helical region.	Proline	161-168	keratin 14	Homo sapiens	133-143
1939237-12	1991	We propose that the primary sequence of substrates for ERK1 and ERK2 protein kinases can be generalized as -Pro-Xaan-Ser/Thr-Pro- (where Xaa is a neutral or basic amino acid and n = 1 or 2).	Proline	108-111	mitogen-activated protein kinase 3	Homo sapiens	55-59
1939237-12	1991	We propose that the primary sequence of substrates for ERK1 and ERK2 protein kinases can be generalized as -Pro-Xaan-Ser/Thr-Pro- (where Xaa is a neutral or basic amino acid and n = 1 or 2).	Proline	108-111	mitogen-activated protein kinase 1	Homo sapiens	64-68
1939259-8	1991	1) In hemolymph one or more LAP-like enzymes rapidly and sequentially cleave alpha-BCP(3-9) or other small peptides lacking Pro at positions 1 or 2 or Tyr at position 1.	Proline	124-127	LAP	Homo sapiens	28-31
1794572-2	1991	New results are presented on the structure of squid rhodopsin, which possesses an extensive proline-rich repeat at its C-terminus, using negative-stain electron microscopy.	Proline	92-99	rhodopsin	Homo sapiens	52-61
1951674-2	1991	Amino acid analysis of the purified proteoglycan and the chondroitinase digestion products reveals that the polypeptide backbone is a proline-rich protein.	Proline	134-141	galactosamine (N-acetyl)-6-sulfatase	Rattus norvegicus	57-71
1815499-0	1991	Proline hydroxylation by soybean lipoxygenase.	Proline	0-7	linoleate 9S-lipoxygenase-4	Glycine max	33-45
1834657-7	1991	The high affinity LDL binding to LDL receptor-negative fibroblasts could be dissociated by approximately 80 and 54% with 5 mg/ml proline and 30 mg/ml NaCl, respectively, but not with dextran sulfate.	Proline	129-136	low density lipoprotein receptor	Homo sapiens	33-45
1667689-6	1991	The major form of Anolis alpha-MSH is nonacetylated and has the following novel primary sequence: Ser-Tyr-Ala-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro(Val-amide).	Proline	142-145	alpha-msh	Anolis carolinensis	25-34
1935798-5	1991	Both cortisol and IL-1 alpha decreased the incorporation of [3H]proline into collagenase-digestible protein (CDP) and reduced alpha 1(I)procollagen mRNA levels at 72 h. Noncollagen protein (NCP) labeling was increased by IL-1 and decreased by cortisol.	Proline	64-71	interleukin 1 alpha	Mus musculus	18-28
1935798-5	1991	Both cortisol and IL-1 alpha decreased the incorporation of [3H]proline into collagenase-digestible protein (CDP) and reduced alpha 1(I)procollagen mRNA levels at 72 h. Noncollagen protein (NCP) labeling was increased by IL-1 and decreased by cortisol.	Proline	64-71	cut-like homeobox 1	Mus musculus	77-107
1935798-5	1991	Both cortisol and IL-1 alpha decreased the incorporation of [3H]proline into collagenase-digestible protein (CDP) and reduced alpha 1(I)procollagen mRNA levels at 72 h. Noncollagen protein (NCP) labeling was increased by IL-1 and decreased by cortisol.	Proline	64-71	cut-like homeobox 1	Mus musculus	109-112
1935798-5	1991	Both cortisol and IL-1 alpha decreased the incorporation of [3H]proline into collagenase-digestible protein (CDP) and reduced alpha 1(I)procollagen mRNA levels at 72 h. Noncollagen protein (NCP) labeling was increased by IL-1 and decreased by cortisol.	Proline	64-71	interleukin 1 complex	Mus musculus	18-22
1802860-1	1991	The solution-state conformations of eight proline-containing peptide fragments found in human salivary proline-rich glycoprotein (PRG) were investigated in 2 x distilled water (treated with metal ion chelating resin) using 13C-nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopy.	Proline	42-49	proline rich protein BstNI subfamily 3	Homo sapiens	130-133
1802860-6	1991	Since proline is the major amino acid present in native PRG, these localized conformations may contribute to PRG"s global conformation and act as a primary force in determining its biological activities.	Proline	6-13	proline rich protein BstNI subfamily 3	Homo sapiens	56-59
1802860-6	1991	Since proline is the major amino acid present in native PRG, these localized conformations may contribute to PRG"s global conformation and act as a primary force in determining its biological activities.	Proline	6-13	proline rich protein BstNI subfamily 3	Homo sapiens	109-112
1656070-3	1991	By using a transient-transfection system, the major domain of the HNF1 polypeptide involved in transcriptional activation of the large surface antigen promoter in the human hepatoma cell line HepG2.1 has been mapped to a region that is rich in glutamine and proline residues (9 of 18) and is different from the previously identified regions of this factor responsible for in vitro transcriptional activation of a promoter containing human albumin promoter HNF1 binding sites.	Proline	258-265	HNF1 homeobox A	Homo sapiens	66-70
1815499-1	1991	The lipoxygenase-catalyzed hydroxylation of proline was studied in vitro in the presence of linoleic acid.	Proline	44-51	linoleate 9S-lipoxygenase-4	Glycine max	4-16
1815499-6	1991	It is suggested that free-radical products of linoleic acid peroxidation may co-oxygenate proline in the presence of lipoxygenase.	Proline	90-97	linoleate 9S-lipoxygenase-4	Glycine max	117-129
1919003-2	1991	Comparison of amino acid sequences of the alpha-chain fragment of C4, C4d, has shown C4A- and C4B-specific sequences at residues 1101-1106 are the only consistent structural difference between isotype, i.e., Pro, Cys, Pro, Val, Leu, Asp in C4A and Leu, Ser, Pro, Val Ile, His in C4B.	Proline	208-211	complement C4B (Chido blood group)	Homo sapiens	94-97
1919003-2	1991	Comparison of amino acid sequences of the alpha-chain fragment of C4, C4d, has shown C4A- and C4B-specific sequences at residues 1101-1106 are the only consistent structural difference between isotype, i.e., Pro, Cys, Pro, Val, Leu, Asp in C4A and Leu, Ser, Pro, Val Ile, His in C4B.	Proline	218-221	complement C4B (Chido blood group)	Homo sapiens	94-97
1919003-2	1991	Comparison of amino acid sequences of the alpha-chain fragment of C4, C4d, has shown C4A- and C4B-specific sequences at residues 1101-1106 are the only consistent structural difference between isotype, i.e., Pro, Cys, Pro, Val, Leu, Asp in C4A and Leu, Ser, Pro, Val Ile, His in C4B.	Proline	218-221	complement C4B (Chido blood group)	Homo sapiens	94-97
1923755-1	1991	I have cloned a yeast gene, RGM1, which encodes a proline-rich zinc, finger protein.	Proline	50-57	Rgm1p	Saccharomyces cerevisiae S288C	28-32
1918036-10	1991	Thus, we propose that ideal substrates for human heart chymase should contain the structure nXaa-Pro-[Phe, Tyr, or Trp]-Yaa-Yaa, where n greater than or equal to 6; Xaa = any amino acid; Yaa = any amino acid except proline.	Proline	215-222	chymase 1	Homo sapiens	55-62
1923818-5	1991	The two predicted GAL11 proteins show high overall amino acid conservation and an unusual amino acid composition including 18% glutamine, 10% asparagine (S. cerevisiae) or 7% (K. lactis), and 8% proline (K. lactis) or 5% (S. cerevisiae) residues.	Proline	195-202	Gal11p	Saccharomyces cerevisiae S288C	18-23
1840561-0	1991	Pro-347-Arg mutation of the rhodopsin gene in autosomal dominant retinitis pigmentosa.	Proline	0-3	rhodopsin	Homo sapiens	28-37
1911779-0	1991	Effects of proline mutations on the unfolding and refolding of human lysozyme: the slow refolding kinetic phase does not result from proline cis-trans isomerization.	Proline	11-18	lysozyme	Homo sapiens	69-77
1911779-1	1991	The unfolding and refolding kinetics of six proline mutants of the human lysozyme (h-lysozyme) were carried out and compared to that of the wild-type protein.	Proline	44-51	lysozyme	Homo sapiens	73-81
1911779-2	1991	Our results show that the slow refolding phase observed in the h-lysozyme refolding kinetics cannot be ascribed to proline isomerization reactions.	Proline	115-122	lysozyme	Homo sapiens	65-73
1911779-3	1991	The h-lysozyme contains two proline residues at positions 71 and 103, both in the trans conformation in the native state.	Proline	28-35	lysozyme	Homo sapiens	6-14
1911779-12	1991	We also discuss the effect of proline mutations on the energetics of the folding pathway of the h-lysozyme in water.	Proline	30-37	lysozyme	Homo sapiens	98-106
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Proline	82-85	angiotensinogen	Homo sapiens	41-56
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Proline	82-85	renin	Homo sapiens	302-307
1922035-4	1991	Sequence analysis of cDNA clones encoding p80/85 revealed an amino-terminal domain composed of six copies of a direct tandem repeat, each repeat containing 37 amino acids, a carboxyl-terminal SH3 domain, and an interdomain region composed of a highly charged acidic region and a region rich in proline, serine, and threonine.	Proline	294-301	coilin	Homo sapiens	42-45
1716370-6	1991	The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation.	Proline	35-38	fibrinogen beta chain	Homo sapiens	73-83
1716370-6	1991	The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation.	Proline	35-38	fibrinogen beta chain	Homo sapiens	113-123
1716370-6	1991	The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation.	Proline	35-38	fibrinogen beta chain	Homo sapiens	113-123
1654597-4	1991	The repression function was mapped to the glutamine- and proline-rich NH2-terminus of WT1; fusion of this domain to the zinc finger region of EGR-1 converted EGR-1 into a transcriptional repressor.	Proline	57-64	WT1 transcription factor	Homo sapiens	86-89
1654597-4	1991	The repression function was mapped to the glutamine- and proline-rich NH2-terminus of WT1; fusion of this domain to the zinc finger region of EGR-1 converted EGR-1 into a transcriptional repressor.	Proline	57-64	early growth response 1	Homo sapiens	142-147
1654597-4	1991	The repression function was mapped to the glutamine- and proline-rich NH2-terminus of WT1; fusion of this domain to the zinc finger region of EGR-1 converted EGR-1 into a transcriptional repressor.	Proline	57-64	early growth response 1	Homo sapiens	158-163
1923755-3	1991	The proline-rich region of RGM1 attached to a heterologous DNA binding domain is able to repress the expression of the target gene.	Proline	4-11	Rgm1p	Saccharomyces cerevisiae S288C	27-31
1923788-0	1991	A CCA/CCG neutral dimorphism in the codon for Pro 626 of the human protein S gene PS alpha (PROS1).	Proline	46-49	protein S	Homo sapiens	92-97
1892319-5	1991	These cDNA, designated SMUC or MUC2, contain 69 nucleotide tandem repeats that encode a repetitive peptide that is extremely rich in threonine and proline.	Proline	147-154	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	23-27
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Proline	40-43	integrin alpha 5 (fibronectin receptor alpha)	Mus musculus	165-170
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Proline	40-43	fibronectin 1	Mus musculus	153-155
1892319-5	1991	These cDNA, designated SMUC or MUC2, contain 69 nucleotide tandem repeats that encode a repetitive peptide that is extremely rich in threonine and proline.	Proline	147-154	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	31-35
1958054-3	1991	The active form is generated upon proteolytic cleavage of the N-terminal prophospholipase A2 activation peptide (PLAP), with the sequence Asp-Ser-Gly-Ile-Ser-Pro-Arg (DSGISPR).	Proline	158-161	phospholipase A2 activating protein	Homo sapiens	73-111
1958054-3	1991	The active form is generated upon proteolytic cleavage of the N-terminal prophospholipase A2 activation peptide (PLAP), with the sequence Asp-Ser-Gly-Ile-Ser-Pro-Arg (DSGISPR).	Proline	158-161	phospholipase A2 activating protein	Homo sapiens	113-117
1898067-4	1991	A series of analogs of the precursor-specific region of preproparathyroid hormone have been prepared which contain substitutions of either proline or a charged amino acid within the hydrophobic core.	Proline	139-146	parathyroid hormone	Homo sapiens	56-81
1715292-2	1991	One of these antibodies completely abolishes the potentiation of plasmin generation observed upon incubation of the zymogens pro-u-PA and plasminogen with U937 cells.	Proline	125-128	plasminogen activator, urokinase	Homo sapiens	129-133
1911708-3	1991	Interleukin-1 (IL-1, 1-10 ng/ml) modestly increased the synthesis of collagens I and III (measured by tritiated proline incorporation into specific electrophoretic bands), whereas transforming growth factor-beta (TGF-beta) or platelet-derived growth factor (PDGF) markedly stimulated production of these interstitial collagens.	Proline	112-119	interleukin 1 alpha	Homo sapiens	0-25
1923529-5	1991	Chicken JunD contains stretches of oligoglycines, alanines and prolines, possibly acting as hinges that connect functionally distinct domains of the protein.	Proline	63-71	JunD proto-oncogene, AP-1 transcription factor subunit	Gallus gallus	8-12
1907971-9	1991	Thus, the optimum consensus sequence for phosphorylation by p44mpk was defined as Pro-X-(Ser/Thr)-Pro, where X is a variable amino acid residue, but ideally not a Pro.	Proline	82-85	interferon induced protein 44	Homo sapiens	60-63
1868097-4	1991	At least five such states are observed, for example, for the well-resolved A14 beta H3 group, and K3, which is six residues sequentially removed from the nearest proline, i.e., P9, shows two sets.	Proline	162-169	adenylate kinase 3	Homo sapiens	75-100
1714722-2	1991	Results obtained from both peptide mapping and fast atom bombardment mass spectrometry indicate that tyrosine 67 in the sequence -Thr-Thr-His-Tyr67-Gly-Ser-Leu-Pro-Gln-Lys- in bovine MBP is the specific phosphorylation site.	Proline	160-163	myelin basic protein	Bos taurus	183-186
1683181-0	1991	Nondestructive amino acid analysis at the picomole level of proline-containing peptides using aminopeptidase M and prolidase: application to peptides containing tyrosine sulfate.	Proline	60-67	alanyl aminopeptidase, membrane	Gallus gallus	94-110
1714452-3	1991	The mouse gene, Muc-1, encodes an integral membrane protein with 40% of its coding capacity made up of serine, threonine, and proline, a composition typical of a highly O-glycosylated protein.	Proline	126-133	mucin 1, transmembrane	Mus musculus	16-21
1793440-6	1991	This mutation in the LDL-R gene (LDL-R664 mutation) results in the substitution of leucine (Leu) for proline (Pro) at amino acid 664 and is known to slow processing of the LDL-R precursor to the mature form and to reduce the affinity of the receptor on the cell surface for LDL.	Proline	101-108	low density lipoprotein receptor	Homo sapiens	21-26
1793440-6	1991	This mutation in the LDL-R gene (LDL-R664 mutation) results in the substitution of leucine (Leu) for proline (Pro) at amino acid 664 and is known to slow processing of the LDL-R precursor to the mature form and to reduce the affinity of the receptor on the cell surface for LDL.	Proline	101-108	low density lipoprotein receptor	Homo sapiens	33-38
1793440-6	1991	This mutation in the LDL-R gene (LDL-R664 mutation) results in the substitution of leucine (Leu) for proline (Pro) at amino acid 664 and is known to slow processing of the LDL-R precursor to the mature form and to reduce the affinity of the receptor on the cell surface for LDL.	Proline	110-113	low density lipoprotein receptor	Homo sapiens	21-26
1793440-6	1991	This mutation in the LDL-R gene (LDL-R664 mutation) results in the substitution of leucine (Leu) for proline (Pro) at amino acid 664 and is known to slow processing of the LDL-R precursor to the mature form and to reduce the affinity of the receptor on the cell surface for LDL.	Proline	110-113	low density lipoprotein receptor	Homo sapiens	33-38
1910027-1	1991	Expression of aryl hydrocarbon hydroxylase (AHH) and the corresponding gene, Cyp1A1, or P(1)450 in mice, in C57BL/6 mouse hepatocytes in primary culture was investigated after exposure to benz[a]-anthracene with respect to proline-related metabolic regulation.	Proline	223-230	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	14-42
1910027-1	1991	Expression of aryl hydrocarbon hydroxylase (AHH) and the corresponding gene, Cyp1A1, or P(1)450 in mice, in C57BL/6 mouse hepatocytes in primary culture was investigated after exposure to benz[a]-anthracene with respect to proline-related metabolic regulation.	Proline	223-230	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	44-47
1910027-1	1991	Expression of aryl hydrocarbon hydroxylase (AHH) and the corresponding gene, Cyp1A1, or P(1)450 in mice, in C57BL/6 mouse hepatocytes in primary culture was investigated after exposure to benz[a]-anthracene with respect to proline-related metabolic regulation.	Proline	223-230	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	77-83
1910027-5	1991	However, treatment with delta 1-pyrroline-5-carboxylic acid (P5C), a biosynthetic precursor for proline, dose-dependently increased basal AHH activities in the cells cultivated in Way-(-pro).	Proline	96-103	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	138-141
1910027-6	1991	Benz[a]anthracene induction of AHH in cells cultivated in Way(-pro) was additively increased in the presence of P5C as much as with proline.	Proline	132-139	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	31-34
1910027-11	1991	Our observations suggest that induction of AHH after treatment with polycyclic aromatic hydrocarbon is dependent on proline-related metabolism which influences the transcriptional process of P(1)450 gene expression.	Proline	116-123	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	43-46
1938100-3	1991	Substitution of the Arg residue occupying position 2 of [Sar1,Ile8]ANG II (pA2 8.1) by Gly, Ala, Nle, Phe, Pro or Sar reduced the antagonist potency to pA2 = 7.0, 6.8, 6.7, 6.8, 5.8 and 5.3, respectively.	Proline	107-110	angiotensinogen	Rattus norvegicus	67-73
1767588-1	1991	The use of proline as a nitrogen source causes hypersensitivity to 5-fluoro-orotic acid (5FOA) and allows up to 40-fold less of this drug to be used to select for the loss of URA3 function in Saccharomyces cerevisiae.	Proline	11-18	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	175-179
2068081-5	1991	The ERG9-encoded protein contains a PEST consensus motif (rich in proline, glutamic acid, serine, and threonine) present in many proteins with short cellular half-lives.	Proline	66-73	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	4-8
1647310-3	1991	Des-IGF I and IGF I increased [3H] thymidine incorporation into DNA, [3H]proline incorporation into collagen and noncollagen protein, and the mitotic index in intact calvariae.	Proline	73-80	insulin-like growth factor 1	Rattus norvegicus	4-9
1647310-3	1991	Des-IGF I and IGF I increased [3H] thymidine incorporation into DNA, [3H]proline incorporation into collagen and noncollagen protein, and the mitotic index in intact calvariae.	Proline	73-80	insulin-like growth factor 1	Rattus norvegicus	14-19
1681421-5	1991	Further investigations on these two cytosolic enzymes show that pyroglutamyl- and proline-containing peptides are inhibitors of each TRH-degrading enzyme.	Proline	82-89	thyrotropin releasing hormone	Rattus norvegicus	133-136
1712019-6	1991	GP-II corresponded to a part of GP-I, its sequence being Leu-Ser*-Glu-Ser*-Thr*-Thr*-Gln-Leu-Pro-Gly, where asterisks denote amino acids to which an alpha-GalNAc residue is attached.	Proline	93-96	glucose-6-phosphate isomerase	Homo sapiens	0-4
2070049-7	1991	Amino acid sequence analysis of the abnormal peptide indicated that A alpha proline-18, the second residue from the NH2-terminus of the fibrin alpha-chain, was replaced by leucine.	Proline	76-83	Fc gamma receptor and transporter	Homo sapiens	143-154
2070049-9	1991	The discovery of this abnormal fibrinogen supports the findings that A alpha proline-18 is important as part of the polymerization site in the NH2-terminus of the fibrin alpha-chain.	Proline	77-84	Fc gamma receptor and transporter	Homo sapiens	170-181
1711570-0	1991	Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype.	Proline	93-100	CD46 molecule	Homo sapiens	0-25
1828370-5	1991	Substitution of proline, a helix-destabilizing amino acid, for leucine (residue 8) of a predicted amphipathic alpha-helix (residues 3-12), IFN gamma (1-39) [Pro]8, resulted in a substantial reduction in the helical content of the peptide, supporting the presence of helical structure in this region.	Proline	16-23	interferon gamma	Mus musculus	139-148
1651438-5	1991	The amount of ALP activity in SaOS-2 subpopulations was proportional to collagen production ([3H]proline incorporation into collagenase-digestible protein; r = .84, P less than .005), and to parathyroid hormone (PTH)-linked synthesis of cyclic adenosine monophosphate (cAMP) (r = .88, P less than .01).	Proline	97-104	alkaline phosphatase, placental	Homo sapiens	14-17
1913589-8	1991	The results focused on the importance of efficient proline re-utilization for normal collagen and elastin synthesis and deposition.	Proline	51-58	elastin	Homo sapiens	98-105
1711024-11	1991	This protein is highly homologous with the AroP (general aromatic transport) system of E. coli (59.6% identity) and to a lesser extent with the yeast permeases CAN1 (arginine), PUT4 (proline), and HIP1 (histidine) of Saccharomyces cerevisiae.	Proline	183-190	arginine permease CAN1	Saccharomyces cerevisiae S288C	160-164
1906047-3	1991	A single nucleotide substitution in the codon for amino acid 113 of the mature protein (GCC to CCC) was found, resulting in the replacement of alanine by proline.	Proline	154-161	guanylate cyclase 2C	Homo sapiens	88-91
1711024-11	1991	This protein is highly homologous with the AroP (general aromatic transport) system of E. coli (59.6% identity) and to a lesser extent with the yeast permeases CAN1 (arginine), PUT4 (proline), and HIP1 (histidine) of Saccharomyces cerevisiae.	Proline	183-190	proline permease PUT4	Saccharomyces cerevisiae S288C	177-181
1711024-11	1991	This protein is highly homologous with the AroP (general aromatic transport) system of E. coli (59.6% identity) and to a lesser extent with the yeast permeases CAN1 (arginine), PUT4 (proline), and HIP1 (histidine) of Saccharomyces cerevisiae.	Proline	183-190	histidine permease	Saccharomyces cerevisiae S288C	197-201
1903934-0	1991	Interleukin-1 beta-induced changes in the kinetic constants of L-proline uptake in human skin fibroblasts.	Proline	63-72	interleukin 1 beta	Homo sapiens	0-18
2038313-3	1991	By using cotransfection experiments with HeLa cells, we show that the proline-rich transcriptional activation domain of CTF-1, when fused to the GAL4 DNA-binding domain, synergizes with each of the two estrogen receptor-activating regions.	Proline	70-77	cardiotrophin 1	Homo sapiens	120-125
2038313-3	1991	By using cotransfection experiments with HeLa cells, we show that the proline-rich transcriptional activation domain of CTF-1, when fused to the GAL4 DNA-binding domain, synergizes with each of the two estrogen receptor-activating regions.	Proline	70-77	estrogen receptor 1	Homo sapiens	202-219
2038313-4	1991	Cooperative DNA binding between the GAL4-CTF-1 fusion and the estrogen receptor does not occur in vitro, and in vivo competition experiments demonstrate that both activators can be specifically inhibited by the overexpression of a proline-rich competitor, indicating that a common limiting factor is mediating their transcriptional activation functions.	Proline	231-238	galectin 4	Homo sapiens	36-40
2038313-4	1991	Cooperative DNA binding between the GAL4-CTF-1 fusion and the estrogen receptor does not occur in vitro, and in vivo competition experiments demonstrate that both activators can be specifically inhibited by the overexpression of a proline-rich competitor, indicating that a common limiting factor is mediating their transcriptional activation functions.	Proline	231-238	cardiotrophin 1	Homo sapiens	41-46
2038313-4	1991	Cooperative DNA binding between the GAL4-CTF-1 fusion and the estrogen receptor does not occur in vitro, and in vivo competition experiments demonstrate that both activators can be specifically inhibited by the overexpression of a proline-rich competitor, indicating that a common limiting factor is mediating their transcriptional activation functions.	Proline	231-238	estrogen receptor 1	Homo sapiens	62-79
2038334-8	1991	CCG1 contains a sequence similar to the putative DNA-binding domain of HMG1 in addition to the previously detected amino acid sequences common in nuclear proteins, such as a proline cluster and a nuclear translocation signal.	Proline	174-181	TATA-box binding protein associated factor 1	Homo sapiens	0-4
2026586-5	1991	The N-terminal amino acid sequence, Arg-Ala-Pro-Lys-Glu-Val-Pro-Leu-, is different from the N-terminal sequence of any other cytochrome P-450s so far reported.	Proline	44-47	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	125-141
1841717-5	1991	Three criteria (N-terminal amino acid sequence, amino acid composition, and sequence of a cDNA) proved that the seed coat 35-kilodalton protein was PRP1, a member of a proline-rich gene family expressed in hypocotyls and other soybean tissues.	Proline	168-175	repetitive proline-rich cell wall protein 1	Glycine max	148-152
2033048-0	1991	Mimicking the active site of protein disulfide-isomerase by substitution of proline 34 in Escherichia coli thioredoxin.	Proline	76-83	protein-disulfide isomerase	Escherichia coli	29-56
1903934-1	1991	The effects of interleukin-1 beta (IL-1) on L-proline uptake in human skin fibroblasts were investigated.	Proline	44-53	interleukin 1 beta	Homo sapiens	15-33
1903934-1	1991	The effects of interleukin-1 beta (IL-1) on L-proline uptake in human skin fibroblasts were investigated.	Proline	44-53	interleukin 1 beta	Homo sapiens	35-39
1903934-6	1991	To determine whether IL-1-induced prostaglandin release influences proline uptake, indomethacin (14 microM) was added as a cyclo-oxygenase inhibitor.	Proline	67-74	interleukin 1 beta	Homo sapiens	21-25
1903934-8	1991	When IL-1 was tested in the presence of indomethacin, the inhibition of L-proline uptake was still observed, with values between those obtained with each substance in isolation.	Proline	72-81	interleukin 1 beta	Homo sapiens	5-9
1903934-9	1991	This suggests that the inhibitory effect of IL-1 on proline uptake by skin fibroblast does not only involve the prostaglandins that accumulate in the medium, but no firm conclusion can be drawn, due to the fact that the inhibition by the two agents was not statistically independent.	Proline	52-59	interleukin 1 beta	Homo sapiens	44-48
1903934-11	1991	Therefore the two systems of proline uptake in skin fibroblasts are probably inhibited by IL-1 via different mechanisms.	Proline	29-36	interleukin 1 beta	Homo sapiens	90-94
1902476-11	1991	The RP-4 had a unique amino-terminal amino sequence and was rich in Gly, Pro, Glx, and Ala residues.	Proline	73-76	RGD1559532	Rattus norvegicus	4-8
1747407-8	1991	It is assumed that these proline residues and the cyclic structure are necessary for the manifestation of the inhibiting effect of the mammalian prolactin N-terminal dodecapeptide on proline-specific proteinases.	Proline	25-32	prolactin	Homo sapiens	145-154
2018041-4	1991	This nucleotide alteration results in the substitution of proline for the highly conserved leucine residue at position 285 of the ND1 protein.	Proline	58-65	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	130-133
1678608-1	1991	The substrate specificity of dipeptidyl peptidase IV (dipeptidyl peptide hydrolase, EC 3.4.14.5) from pig kidney was investigated, using a series of substrates, in which the amino-acid residue in position P1, a structural derivative of proline, was altered with respect to ring size and substituents.	Proline	236-243	dipeptidyl peptidase 4	Sus scrofa	29-52
1678608-2	1991	It was demonstrated that dipeptidyl peptidase IV hydrolyses substrates of the type Ala-X-pNA, where X is proline (Pro), (R)-thiazolidine-4-carboxylic acid (Thz), (S)-pipecolic acid (Pip), (S)-oxazolidine-4-carboxylic acid (Oxa), or (S)-azetidine-2-carboxylic acid (Aze).	Proline	105-112	dipeptidyl peptidase 4	Sus scrofa	25-48
1678608-2	1991	It was demonstrated that dipeptidyl peptidase IV hydrolyses substrates of the type Ala-X-pNA, where X is proline (Pro), (R)-thiazolidine-4-carboxylic acid (Thz), (S)-pipecolic acid (Pip), (S)-oxazolidine-4-carboxylic acid (Oxa), or (S)-azetidine-2-carboxylic acid (Aze).	Proline	114-117	dipeptidyl peptidase 4	Sus scrofa	25-48
1917292-0	1991	Biological and conformational studies of [Val4]morphiceptin and [D-Val4]morphiceptin analogs incorporating cis-2-aminocyclopentane carboxylic acid as a peptidomimetic for proline.	Proline	171-178	suppressor of cytokine signaling 2	Homo sapiens	107-112
2030914-0	1991	The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.	Proline	121-128	Casitas B-lineage lymphoma	Mus musculus	37-42
2017167-1	1991	The Saccharomyces cerevisiae PUT3 gene encodes a transcriptional activator that binds to DNA sequences in the promoters of the proline utilization genes and is required for the basal and induced expression of the enzymes of this pathway.	Proline	127-134	Put3p	Saccharomyces cerevisiae S288C	29-33
1894441-4	1991	Specifically, the pentapeptide sequence of [Trp3]-beta-CM-5, H-Tyr-Pro-Trp-Pro-Gly-OH (I) was modified at Pro-2 and Pro-4 by D-Pro substitutions to provide two diastereometric analogs, [Trp3-D-Pro-4]-beta-CM-5 (II) and [D-Pro2,4,Trp3]-beta-CM-5 (III).	Proline	67-70	tRNA-Pro (anticodon TGG) 3-1	Homo sapiens	44-54
1894441-4	1991	Specifically, the pentapeptide sequence of [Trp3]-beta-CM-5, H-Tyr-Pro-Trp-Pro-Gly-OH (I) was modified at Pro-2 and Pro-4 by D-Pro substitutions to provide two diastereometric analogs, [Trp3-D-Pro-4]-beta-CM-5 (II) and [D-Pro2,4,Trp3]-beta-CM-5 (III).	Proline	75-78	tRNA-Pro (anticodon TGG) 3-1	Homo sapiens	44-54
1850191-0	1991	Proline at position 36: a new transthyretin mutation associated with familial amyloidotic polyneuropathy.	Proline	0-7	transthyretin	Homo sapiens	30-43
2019589-8	1991	DNA sequence analysis of cM32 indicated that MAGP contains two structurally dissimilar regions, an amino-terminal domain containing high levels of glutamine, proline, and acidic amino acids and a carboxyl-terminal domain containing all 13 of the cysteine residues and most of the basic amino acids.	Proline	158-165	microfibril associated protein 2	Bos taurus	45-49
2010091-7	1991	Expression of AP-2 in mammalian cells demonstrates that transcriptional activation requires an additional amino-terminal domain that contains an unusually high concentration of proline residues.	Proline	177-184	transcription factor AP-2 alpha	Homo sapiens	14-18
2010091-8	1991	This proline-rich activation domain also functions when attached to the heterologous DNA-binding region of the GAL4 protein.	Proline	5-12	galectin 4	Homo sapiens	111-115
2002539-7	1991	The base exchange at this position was expected to change amino acid 311 of the envelope glycoprotein, gp120, from proline to serine, which is located in a variable region containing type-specific immunodominant epitopes.	Proline	115-122	endogenous retrovirus group K member 20	Homo sapiens	80-101
2002539-7	1991	The base exchange at this position was expected to change amino acid 311 of the envelope glycoprotein, gp120, from proline to serine, which is located in a variable region containing type-specific immunodominant epitopes.	Proline	115-122	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	103-108
2002066-0	1991	Single proline substitutions in predicted alpha-helices of murine granulocyte-macrophage colony-stimulating factor result in a loss in bioactivity and altered glycosylation.	Proline	7-14	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	66-114
1848551-11	1991	Inhibition by L-proline could be reversed in the binding studies by increasing the amount of apo(a); and L-proline-Sepharose bound plasma Lp(a), suggesting that L-proline acted as a ligand for the kringle-4-like domain(s) of apo(a) involved in the binding of apoB-Lp.	Proline	105-114	lipoprotein(a)	Homo sapiens	138-143
1848551-11	1991	Inhibition by L-proline could be reversed in the binding studies by increasing the amount of apo(a); and L-proline-Sepharose bound plasma Lp(a), suggesting that L-proline acted as a ligand for the kringle-4-like domain(s) of apo(a) involved in the binding of apoB-Lp.	Proline	105-114	lipoprotein(a)	Homo sapiens	138-143
1848551-12	1991	The binding of apo(a) to proline and hydroxyproline could be responsible for the binding of apo(a) to the subendothelial extracellular matrix, i.e. domains of proteins rich in proline or hydroxyproline (e.g. collagen and elastin).	Proline	25-32	elastin	Homo sapiens	221-228
1848551-12	1991	The binding of apo(a) to proline and hydroxyproline could be responsible for the binding of apo(a) to the subendothelial extracellular matrix, i.e. domains of proteins rich in proline or hydroxyproline (e.g. collagen and elastin).	Proline	44-51	elastin	Homo sapiens	221-228
1881870-0	1991	Confirmation of the predicted source of a slow folding reaction: proline 8 of bovine pancreatic trypsin inhibitor.	Proline	65-72	trophoblast Kunitz domain protein 1	Bos taurus	96-113
1881870-4	1991	All two-disulfide mutants of BPTI investigated thus far have two very slow folding reactions which have characteristics of proline isomerization.	Proline	123-130	spleen trypsin inhibitor I	Bos taurus	29-33
2013328-4	1991	The carboxyl group of proline and the ethyl ester group or the n-propylamide group in the oxirane ring were necessary, the ethyl ester group or the n-propylamide group being particularly effective for distinguishing cathepsin B from other cysteine proteinases such as cathepsins L and H, and calpains.	Proline	22-29	cathepsin B	Homo sapiens	216-227
1825316-2	1991	125I-labeled fibronectin was inhibited from binding to the fungus by unlabeled human plasma fibronectin and by Arg-Gly-Asp (RGD), Gly-Arg-Gly-Glu-Ser-Pro (GRGESP), and Gly-Arg-Gly-Asp-Thr-Pro (GRGDTP), but binding was not inhibited by Gly-Arg-Gly-Asp-Ser-Pro.	Proline	150-153	fibronectin 1	Homo sapiens	13-24
1857535-2	1991	In the present study, a neurite promoting activity of thrombin inhibitors such as hirudin, D-Phe,Pro,Arg-CH2Cl, and paraamidinophenylalanine derivatives, was found in rat embryo (E17) septal neurons in primary culture.	Proline	97-100	coagulation factor II	Rattus norvegicus	54-62
1368631-2	1991	In the hope of finding PEP inhibitors in milk proteins, we synthesized a total of 37 human beta-casein peptide fragments containing proline residues.	Proline	132-139	casein beta	Homo sapiens	91-102
1999271-2	1991	A peptide corresponding to the COOH-terminal domain of the GLUT1 glucose transporter (Thr-Pro-Glu-Glu-Leu-Phe-His-Pro-Leu-Gly-Ala-Asp-Ser-Gln-Val) was synthesized and conjugated to keyhole limpet hemocyanin through the NH2-terminal of the peptide.	Proline	90-93	solute carrier family 2 member 1	Homo sapiens	59-64
1999271-2	1991	A peptide corresponding to the COOH-terminal domain of the GLUT1 glucose transporter (Thr-Pro-Glu-Glu-Leu-Phe-His-Pro-Leu-Gly-Ala-Asp-Ser-Gln-Val) was synthesized and conjugated to keyhole limpet hemocyanin through the NH2-terminal of the peptide.	Proline	114-117	solute carrier family 2 member 1	Homo sapiens	59-64
2009288-3	1991	Protection against proteinase digestion was analyzed by incubating proline-specific endopeptidase, carboxypeptidase Y or aminopeptidase T with beta-casein (f193-202) in the presence of mAb 1C3 or nonspecific mAb 31A4.	Proline	67-74	casein beta	Bos taurus	143-154
1847464-10	1991	In this way we identified a functional nuclear localization signal, Leu-Lys-Arg-Pro-Arg-Ser-Pro-Ser-Ser, encompassing amino acids 379 to 386 of the EBNA-1 protein.	Proline	80-83	EBNA-1	Human gammaherpesvirus 4	148-154
1847464-10	1991	In this way we identified a functional nuclear localization signal, Leu-Lys-Arg-Pro-Arg-Ser-Pro-Ser-Ser, encompassing amino acids 379 to 386 of the EBNA-1 protein.	Proline	92-95	EBNA-1	Human gammaherpesvirus 4	148-154
2045450-3	1991	Microsequence analysis showed that both proteins have the same N-terminal sequence Pro-Ala-Leu-Pro-Glu-Asp-Gly-Gly-Ser-Gly-Ala-Phe..., which is identical with that of (1-146) bFGF extracted from human brain.	Proline	83-86	fibroblast growth factor 2	Homo sapiens	175-179
1995612-12	1991	The data from all of the approaches support a two-site model for the hsp90-binding site in which the critical contact site occurs in region 632-659, which contains a short proline-containing hydrophobic segment and adjacent dipole-plus-cysteine motif that are conserved among all of the hsp90-binding receptors in the superfamily.	Proline	172-179	heat shock protein, 3	Mus musculus	69-74
1899239-7	1991	Thus, the -Ser(Thr)-Pro- motif common to p34cdc2/CDC28-containing protein kinases is the recognition site for mouse CTD kinase.	Proline	20-23	cyclin-dependent kinase 1	Mus musculus	41-48
1671716-4	1991	Here we report that Ala-boroPro and Pro-boroPro, where boroPro is the alpha-amino boronic acid analog of proline, are potent and specific inhibitors of DP-IV, having Ki values in the nanomolar range.	Proline	105-112	dipeptidyl peptidase 4	Homo sapiens	152-157
2028835-7	1991	A 24 h exposure of the osteoblastlike cells to 1000 U/ml of IL-6 reduced [3H]proline incorporation into collagenase-digestible (CDP) protein to 73% of control values (p less than 0.01).	Proline	77-84	interleukin 6	Rattus norvegicus	60-64
1899840-4	1991	PEP possesses multiple potential nucleic acid- and protein- binding regions: a glycine- and asparagine-rich amino terminus, four zinc finger motifs, two very acidic segments, two short basic stretches, and an alanine- and proline-rich carboxyl terminus.	Proline	222-229	Protein on ecdysone puffs	Drosophila melanogaster	0-3
1678611-1	1991	Chemical modification of PLG, comprising replacement of proline or/and leucine by unnatural amino acids led to analogs with high oral efficacy.	Proline	56-63	plasminogen	Homo sapiens	25-28
1999338-1	1991	We describe a simple method for characterizing a frequent polymorphism (that substitutes an arginine for a proline) in the coding sequence of the Tp53 gene in patients with colonic cancer and in a control population.	Proline	107-114	tumor protein p53	Homo sapiens	146-150
2028835-7	1991	A 24 h exposure of the osteoblastlike cells to 1000 U/ml of IL-6 reduced [3H]proline incorporation into collagenase-digestible (CDP) protein to 73% of control values (p less than 0.01).	Proline	77-84	cut-like homeobox 1	Rattus norvegicus	128-131
1846881-4	1991	Sequence analysis presented in this report reveals that this partial BP180 cDNA encodes two protein domains which have primary structures that are characteristic of the triple helical domains of collagens, i.e., glycine appears at every third position and over one-third of the remaining residues are proline.	Proline	301-308	collagen type XVII alpha 1 chain	Homo sapiens	69-74
1898726-1	1991	Serine 127 of human NADH-cytochrome b5 reductase was replaced by proline and alanine by site-directed mutagenesis.	Proline	65-72	cytochrome b5 type A	Homo sapiens	25-38
2066663-0	1991	cDNA cloning of carboxyl ester lipase from human pancreas reveals a unique proline-rich repeat unit.	Proline	75-82	carboxyl ester lipase	Homo sapiens	16-37
2066663-7	1991	This is due to the occurrence of a series of proline-rich tandem repeat units near the carboxyl terminus, and accounts for the previously observed species variation in CEL size and amino acid composition.	Proline	45-52	carboxyl ester lipase	Homo sapiens	168-171
1988962-6	1991	The NH2-terminal region of CPTase contains a leucine-proline motif that is shared by carnitine acetyl- and octanoyltransferases and by choline acetyltransferase.	Proline	53-60	carnitine palmitoyltransferase 2	Homo sapiens	27-33
1905410-0	1991	The effects of the TRH metabolite cyclo(His-Pro) and its analogs on feeding.	Proline	44-47	thyrotropin releasing hormone	Rattus norvegicus	19-22
1905410-1	1991	Cyclo(His-Pro), or cHP, is a putative metabolite of thyrotropin-releasing hormone (TRH), and, like TRH, can inhibit food intake but requires higher doses.	Proline	10-13	calcineurin-like EF-hand protein 1	Rattus norvegicus	19-22
1905410-1	1991	Cyclo(His-Pro), or cHP, is a putative metabolite of thyrotropin-releasing hormone (TRH), and, like TRH, can inhibit food intake but requires higher doses.	Proline	10-13	thyrotropin releasing hormone	Rattus norvegicus	52-81
1905410-1	1991	Cyclo(His-Pro), or cHP, is a putative metabolite of thyrotropin-releasing hormone (TRH), and, like TRH, can inhibit food intake but requires higher doses.	Proline	10-13	thyrotropin releasing hormone	Rattus norvegicus	83-86
1905410-1	1991	Cyclo(His-Pro), or cHP, is a putative metabolite of thyrotropin-releasing hormone (TRH), and, like TRH, can inhibit food intake but requires higher doses.	Proline	10-13	thyrotropin releasing hormone	Rattus norvegicus	99-102
1671823-1	1991	Dipeptidyl peptidase IV preferably hydrolyzes peptides and proteins with a penultimate proline residue.	Proline	87-94	dipeptidyl peptidase 4	Homo sapiens	0-23
1671823-5	1991	We could show that both compounds as well as other tripeptides with a penultimate proline residue are substrates for dipeptidyl peptidase IV.	Proline	82-89	dipeptidyl peptidase 4	Homo sapiens	117-140
1898734-5	1991	These results indicate that the NH2-terminal region of the catalytic domain of galactosyltransferase, and possibly part of the proline-rich "stem" region, is affected by the association with alpha-lactalbumin and is therefore implicated in the binding of acceptor substrates.	Proline	127-134	lactalbumin alpha	Bos taurus	191-208
1987956-1	1991	Ocular findings are presented from 17 unrelated patients with a form of autosomal dominant retinitis pigmentosa and the same cytosine-to-adenine transversion in codon 23 of the rhodopsin gene corresponding to a substitution of histidine for proline in the 23rd amino acid of rhodopsin (designated rhodopsin, Pro-23-His).	Proline	241-248	rhodopsin	Homo sapiens	177-186
1742164-6	1991	(3) Cyclic hexapeptide somatostatin analogs containing 2-Ac5c [trans-(1S,2S)-2-Ac5c, trans-(1R,2R)-2-Ac5c,cis-(1R,2S)-2-Ac5c, and cis-(1S,2R)-2-Ac5c] in place of proline c[(2-Ac5c)6-Phe7-D-Trp8-Lys9-Thr10-Phe11].	Proline	162-169	somatostatin	Homo sapiens	23-35
1820218-8	1991	The N-termini of COUP-TF1 and COUP-TF2 are least similar, but both contain glutamine-rich and proline-rich motifs, putative activation domains.	Proline	94-101	nuclear receptor subfamily 2 group F member 2	Gallus gallus	30-38
1782764-6	1991	Further analysis shows that unique multiple proline consensus regions found in apolipoprotein B-100 are significantly similar to proline dominant regions in vitellogenin.	Proline	44-51	apolipoprotein B	Homo sapiens	79-99
1782764-6	1991	Further analysis shows that unique multiple proline consensus regions found in apolipoprotein B-100 are significantly similar to proline dominant regions in vitellogenin.	Proline	44-51	putative uncharacterized protein LOC400499	Homo sapiens	157-169
1782764-6	1991	Further analysis shows that unique multiple proline consensus regions found in apolipoprotein B-100 are significantly similar to proline dominant regions in vitellogenin.	Proline	129-136	putative uncharacterized protein LOC400499	Homo sapiens	157-169
1799963-9	1991	However, the protein has 2% more proline than other mammalian thyroglobulins.	Proline	33-40	hyaluronan synthase 2	Homo sapiens	21-26
1672294-2	1991	Both mutations occurred in exon 7 of the PAH gene, resulting in the substitution of Trp for Arg at amino acid 252 (R252W) and of Leu for Pro (P281L) at amino acid 281 of the protein.	Proline	137-140	phenylalanine hydroxylase	Homo sapiens	41-44
1742165-1	1991	Poly(X-Gly-Gly), simple structural models for the hydrophobic, proline-devoid, regions of elastin, have been synthesized and studied by circular dichroism and NMR spectroscopies.	Proline	63-70	elastin	Homo sapiens	90-97
2266144-9	1990	Eight labeled peptides, isolated from 6 and 10 S photolabeled myosin, contained the sequence G319-H-V-P-I-X-A-Q326, where X corresponds to labeled proline 324.	Proline	147-154	myosin, heavy chain 10, non-muscle	Gallus gallus	62-68
1846021-4	1991	After 23 h of treatment, 60 to 6,000 pM activin-A increased the rate of [3H]thymidine incorporation into DNA 1.5- to 4.0-fold, and at 600 to 6,000 pM, it enhanced the rate of [3H]proline incorporation into collagen and noncollagen protein by up to 1.7-fold.	Proline	179-186	inhibin subunit beta A	Rattus norvegicus	40-49
1840454-2	1991	These findings implicate the kringle-4-like domains of Apo(a) in the binding of Lp(a) to other ApoB-Lp and point to proline as important in this interaction.	Proline	116-123	aminopeptidase O (putative)	Homo sapiens	55-58
1840454-2	1991	These findings implicate the kringle-4-like domains of Apo(a) in the binding of Lp(a) to other ApoB-Lp and point to proline as important in this interaction.	Proline	116-123	lipoprotein(a)	Homo sapiens	80-85
2266553-2	1990	The aspartic proteinase, endothiapepsin (EC 3.4.23.6), was complexed with a highly potent renin inhibitor, H-261 (t-Boc-His-Pro-Phe-His-LeuOHVal-Ile-His), where OH denotes a hydroxyethylene (-(S) CHOH-CH2-) transition-state isostere in the scissile bond surrogate.	Proline	124-127	renin	Homo sapiens	90-95
2239971-1	1990	In exon 1 at codon 23 of the rhodopsin gene, a mutation resulting in a proline-to-histidine substitution has previously been observed in approximately 12% of American autosomal dominant retinitis pigmentosa (ADRP) patients.	Proline	71-78	rhodopsin	Homo sapiens	29-38
2269352-7	1990	This positioning facilitates the compensatory hydrogen bonding between solvent and residues P-3 and P-4 (relative to proline, P), through the formation of the kink.	Proline	117-124	solute carrier family 10 member 3	Homo sapiens	92-95
2269352-7	1990	This positioning facilitates the compensatory hydrogen bonding between solvent and residues P-3 and P-4 (relative to proline, P), through the formation of the kink.	Proline	117-124	solute carrier family 10 member 4	Homo sapiens	100-103
2250008-7	1990	The results also demonstrated that the presence of a Pro residue next to the Lys-Arg pair prevents the processing of Ren 1 prorenin.	Proline	53-56	renin 1 structural	Mus musculus	117-120
2261483-3	1990	Direct examination of the formation and breakdown of the ES complex shows its formation occurs within milliseconds at 25 degrees C. The best heptapeptide substrate, Dns-Pro-Lys-Arg-Ala-Pro-Trp-Val, is cleaved only between the Arg-Ala (P1-P1") bond with kinetic parameters kcat = 380 s-1 and Km = 3.7 x 10(-4) M. The presence of Lys or Arg in the P1 and P2 positions yields high-turnover substrates.	Proline	185-188	crystallin gamma F, pseudogene	Homo sapiens	346-355
1708261-0	1990	A repeated proline-rich sequence in Sm B/B" and N is a dominant epitope recognized by human and murine autoantibodies.	Proline	11-18	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	36-42
1700979-4	1990	Using mass spectrometry, we determined that the phosphorylation site is threonine 97, present in the conserved triproline loop of MBP, with (partial) sequence -Thr-Pro-Arg-Thr97-Pro-Pro-Pro-.	Proline	164-167	myelin basic protein	Bos taurus	130-133
1700979-4	1990	Using mass spectrometry, we determined that the phosphorylation site is threonine 97, present in the conserved triproline loop of MBP, with (partial) sequence -Thr-Pro-Arg-Thr97-Pro-Pro-Pro-.	Proline	178-181	myelin basic protein	Bos taurus	130-133
1700979-4	1990	Using mass spectrometry, we determined that the phosphorylation site is threonine 97, present in the conserved triproline loop of MBP, with (partial) sequence -Thr-Pro-Arg-Thr97-Pro-Pro-Pro-.	Proline	178-181	myelin basic protein	Bos taurus	130-133
1700979-4	1990	Using mass spectrometry, we determined that the phosphorylation site is threonine 97, present in the conserved triproline loop of MBP, with (partial) sequence -Thr-Pro-Arg-Thr97-Pro-Pro-Pro-.	Proline	178-181	myelin basic protein	Bos taurus	130-133
2246265-7	1990	Among 11 Xaa-Ala-Ser analogues (Xaa = Ala, Asp, Gln, Glu, Ile, Leu, Lys, Met, Phe, Pro, and Ser), MAP cleaved only Met-Ala-Ser.	Proline	83-86	methionine aminopeptidase	Saccharomyces cerevisiae S288C	98-101
2246265-8	1990	MAP also cleaved methionine from other tripeptides whose penultimate amino acid residue is relatively small and/or uncharged (e.g. Pro, Gly, Val, Thr, or Ser) but not when bulky and/or charged (Arg.	Proline	131-134	methionine aminopeptidase	Saccharomyces cerevisiae S288C	0-3
2126014-7	1990	Like both alpha- and beta-adaptins, gamma-adaptin has a proline and glycine-rich hinge region, dividing it into NH2- and COOH-terminal domains.	Proline	56-63	adaptor protein complex AP-1, gamma 1 subunit	Mus musculus	10-49
19912773-6	1990	A unique proline-rich sequence near the N-terminus of the bovine GLUT-1 was not found in other species and this correlated with marked immunoreactivity of the bovine, but not the human or rat, BBB GLUT-1 protein with an antiserum directed against the 15 amino acids at the N-terminus.	Proline	9-16	solute carrier family 2 member 1	Bos taurus	65-71
19912773-6	1990	A unique proline-rich sequence near the N-terminus of the bovine GLUT-1 was not found in other species and this correlated with marked immunoreactivity of the bovine, but not the human or rat, BBB GLUT-1 protein with an antiserum directed against the 15 amino acids at the N-terminus.	Proline	9-16	solute carrier family 2 member 1	Rattus norvegicus	197-203
2246246-1	1990	The pH dependence of Ki for inhibition of prolidase by acetylproline, proline, and trans-1,2-cyclopentanedicarboxylate follows a different pattern in each case, although deprotonation of an enzymic functional group with a pKa value of 6.6 perturbs ligand binding in every instance.	Proline	61-68	peptidase D	Homo sapiens	42-51
1699942-3	1990	The cDNA encodes a proline-, serine-, and glycine-rich nuclear protein designated Nup475 of 319 amino acids that contains two tandemly repeated cysteine- and histidine-containing sequences (CX8CX5CX3H) suggestive of a novel heavy metal-binding domain.	Proline	19-26	zinc finger protein 36	Mus musculus	82-88
2121465-1	1990	TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly.	Proline	14-17	thyrotropin releasing hormone	Rattus norvegicus	0-3
2229048-3	1990	Two bactenecins, with an approximate molecular weight of 7000 and 5000, called Bac7 and Bac5, are characterized by a high content of proline (greater than 45%) and arginine (greater than 23%) residues.	Proline	133-140	cathelicidin-3	Bos taurus	79-83
2229048-3	1990	Two bactenecins, with an approximate molecular weight of 7000 and 5000, called Bac7 and Bac5, are characterized by a high content of proline (greater than 45%) and arginine (greater than 23%) residues.	Proline	133-140	cathelicidin-2	Bos taurus	88-92
2229048-5	1990	Bac7 comprises 59 residues and includes three tandem repeats of a tetradecamer characterized by several Pro-Arg-Pro triplets spaced by single hydrophobic amino acids.	Proline	104-107	cathelicidin-3	Bos taurus	0-4
2145179-2	1990	One mutein, clone 18, which substitutes a threonine and methionine for the alanine and proline at positions 1 and 2 of the N-terminus of fully processed and active IL-1 beta, demonstrated similar activity to that of native IL-1 beta in inducing granulocyte-macrophage colony-stimulating activity (GM-CSA) from cultured fibroblasts.	Proline	87-94	interleukin 1 beta	Homo sapiens	164-173
2121465-1	1990	TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly.	Proline	14-17	thyrotropin releasing hormone	Rattus norvegicus	133-136
2121465-1	1990	TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly.	Proline	166-169	thyrotropin releasing hormone	Rattus norvegicus	0-3
2121465-1	1990	TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly.	Proline	166-169	thyrotropin releasing hormone	Rattus norvegicus	133-136
2233708-0	1990	The SNF5 protein of Saccharomyces cerevisiae is a glutamine- and proline-rich transcriptional activator that affects expression of a broad spectrum of genes.	Proline	65-72	Snf5p	Saccharomyces cerevisiae S288C	4-8
2210258-6	1990	Deglycosylated mucin was separated into three major fractions by reverse-phase chromatography, one of which was enriched with respect to threonine and proline.	Proline	151-158	LOC100508689	Homo sapiens	15-20
2208288-3	1990	DNA sequence analysis revealed two point mutations in highly conserved regions of the gene: an isoleucine to valine change in the PSTAIR region, and a proline to serine change at the C-terminal region of the protein p34.	Proline	151-158	alpha- and gamma-adaptin binding protein	Mus musculus	216-219
2121483-6	1990	In both cell types interferon-gamma selectively inhibited the incorporation of radiolabelled proline into type I collagen.	Proline	93-100	interferon gamma	Homo sapiens	19-35
2211729-2	1990	The oxidation of proline to glutamate in mitochondria requires two enzymes, proline oxidase and pyrroline 5-carboxylate (P5C) dehydrogenase.	Proline	17-24	aldehyde dehydrogenase 4 family, member A1	Rattus norvegicus	121-139
16667813-3	1990	The abi1 and abi2 mutants showed reduced sensitivity to ABA for inhibition of seedling growth, induction of proline accumulation, and alterations in protein synthesis patterns during vegetative growth, but had wild type levels of storage reserves.	Proline	108-115	Protein phosphatase 2C family protein	Arabidopsis thaliana	4-8
16667813-3	1990	The abi1 and abi2 mutants showed reduced sensitivity to ABA for inhibition of seedling growth, induction of proline accumulation, and alterations in protein synthesis patterns during vegetative growth, but had wild type levels of storage reserves.	Proline	108-115	Protein phosphatase 2C family protein	Arabidopsis thaliana	13-17
16667813-4	1990	In contrast, the abi3 mutant had wild type sensitivity for induction of proline accumulation and was only slightly less responsive to ABA with respect to effects on seedling growth and changes in patterns of protein synthesis.	Proline	72-79	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	17-21
16667826-1	1990	Based on localization and high activities of pyrroline-5-carboxylate reductase and proline dehydrogenase activities in soybean nodules, we previously suggested two major roles for pyrroline-5-carboxylate reductase in addition to the production of the considerable quantity of proline needed for biosynthesis; namely, transfer of energy to the location of biological N(2) fixation, and production of NADP(+) to drive the pentose phosphate pathway.	Proline	83-90	pyrroline-5-carboxylate reductase	Glycine max	180-213
2386811-9	1990	We propose that in the repeating sequences of elastin an equilibrium exists between a gamma-turn structure and a beta-turn structure in the Pro-Gly segment resulting in a structure that combines flexibility with strong conformational preferences.	Proline	140-143	elastin	Homo sapiens	46-53
2241932-1	1990	Prolyl endopeptidase is a serine proteinase that specifically cleaves peptides on the carboxy side of proline residues.	Proline	102-109	prolyl endopeptidase	Mus musculus	0-20
2209608-6	1990	This was apparently due to cleavage of the -Gln-Asp- linkage in the sequence H2N-Ala-His-Val-Pro-Gln-Gln-Asp-Glu-, analogous to cleavages described for human apo AI and apo CII.	Proline	93-96	apolipoprotein A1	Homo sapiens	158-164
2217207-3	1990	One amino acid substitution of proline in GRO alpha by leucine in GRO beta and GRO gamma leads to a large predicted change in protein conformation.	Proline	31-38	growth-regulated alpha protein	Cricetulus griseus	42-45
2217207-3	1990	One amino acid substitution of proline in GRO alpha by leucine in GRO beta and GRO gamma leads to a large predicted change in protein conformation.	Proline	31-38	C-X-C motif chemokine ligand 2	Homo sapiens	66-74
2217207-3	1990	One amino acid substitution of proline in GRO alpha by leucine in GRO beta and GRO gamma leads to a large predicted change in protein conformation.	Proline	31-38	C-X-C motif chemokine ligand 3	Homo sapiens	79-88
1975516-4	1990	These differences correlate with high sequence divergence in the proline- and glycine-rich region (residues 47-71) that forms the hsc70 binding site.	Proline	65-72	heat shock protein family A (Hsp70) member 8	Homo sapiens	130-135
1723945-3	1990	The canine shaking pup carries such a mutation, a single base change that substitutes a proline for a histidine near the first transmembrane region of PLP and DM-20.	Proline	88-95	proteolipid protein 1	Canis lupus familiaris	151-154
2168840-8	1990	Incorporation of [14C]proline into 17k protein is diminished by increasing concentrations of colony-stimulating factor 1 (CSF-1).	Proline	22-29	colony stimulating factor 1 (macrophage)	Mus musculus	93-120
2168840-8	1990	Incorporation of [14C]proline into 17k protein is diminished by increasing concentrations of colony-stimulating factor 1 (CSF-1).	Proline	22-29	colony stimulating factor 1 (macrophage)	Mus musculus	122-127
2252883-1	1990	The peptide bonds preceding both Pro-93 and Pro-114, which are in the cis conformation in native RNase A, are predominantly in the trans conformation in the heat-unfolded protein.	Proline	33-36	ribonuclease A family member 1, pancreatic	Homo sapiens	97-104
2252883-1	1990	The peptide bonds preceding both Pro-93 and Pro-114, which are in the cis conformation in native RNase A, are predominantly in the trans conformation in the heat-unfolded protein.	Proline	44-47	ribonuclease A family member 1, pancreatic	Homo sapiens	97-104
2252883-4	1990	The concentration of the trans proline species was determined from the integrated intensities of resonance peaks of the C alpha H protons of Tyr-92 and Asn-113, which are well resolved in the 1D proton NMR spectrum of heat-unfolded RNase A.	Proline	31-38	ribonuclease A family member 1, pancreatic	Homo sapiens	232-239
2252883-8	1990	It is generally believed that the rate of refolding of RNase A is considerably reduced by nonnative proline isomers, such as trans Pro-93.	Proline	100-107	ribonuclease A family member 1, pancreatic	Homo sapiens	55-62
2209608-6	1990	This was apparently due to cleavage of the -Gln-Asp- linkage in the sequence H2N-Ala-His-Val-Pro-Gln-Gln-Asp-Glu-, analogous to cleavages described for human apo AI and apo CII.	Proline	93-96	apolipoprotein C2	Homo sapiens	169-176
2282478-2	1990	Astrocytes are significantly enriched in post-proline cleaving dipeptidyl peptidase II, prolidase and aminopeptidase P activities; neurones and astrocytes contain prolyl endopeptidase.	Proline	46-53	dipeptidylpeptidase 7	Rattus norvegicus	63-86
2126205-3	1990	The protein is a parvalbumin consisting of 108 residues with a blocked amino terminus, a single cysteine, tyrosine, proline and arginine and no histidine, methionine or tryptophan.	Proline	116-123	parvalbumin	Gallus gallus	17-28
2395880-4	1990	The differences in covalent binding properties correlate only with amino acid changes between residues 1101 and 1106 (pro-C4 numbering)--namely, Pro-1101, Cys-1102, Leu-1105, and Asp-1106 in C4A and Leu-1101, Ser-1102, Ile-1105, and His-1106 in C4B, which are located in the C4d region of the alpha chain.	Proline	36-39	complement C4A (Rodgers blood group)	Homo sapiens	191-194
1974901-6	1990	An unexpected finding was the sensitivity of both D-amino acid oxidase activity (proline specific) and D-aspartate oxidase activity to inhibition by agents used in biochemical studies to discriminate between the two enzyme activities.	Proline	81-88	D-amino acid oxidase	Bos taurus	50-70
2395880-4	1990	The differences in covalent binding properties correlate only with amino acid changes between residues 1101 and 1106 (pro-C4 numbering)--namely, Pro-1101, Cys-1102, Leu-1105, and Asp-1106 in C4A and Leu-1101, Ser-1102, Ile-1105, and His-1106 in C4B, which are located in the C4d region of the alpha chain.	Proline	36-39	complement C4B (Chido blood group)	Homo sapiens	245-248
2081598-4	1990	Recent studies have indicated the presence of a point mutation at codon 23 in exon 1 of rhodopsin which results in the substitution of histidine for the highly conserved amino acid proline, suggesting that this mutation is a cause of rhodopsin-linked ADRP.	Proline	181-188	rhodopsin	Homo sapiens	88-97
2081598-4	1990	Recent studies have indicated the presence of a point mutation at codon 23 in exon 1 of rhodopsin which results in the substitution of histidine for the highly conserved amino acid proline, suggesting that this mutation is a cause of rhodopsin-linked ADRP.	Proline	181-188	rhodopsin	Homo sapiens	234-243
2081598-4	1990	Recent studies have indicated the presence of a point mutation at codon 23 in exon 1 of rhodopsin which results in the substitution of histidine for the highly conserved amino acid proline, suggesting that this mutation is a cause of rhodopsin-linked ADRP.	Proline	181-188	perilipin 2	Homo sapiens	251-255
1699121-3	1990	In contrast, the N-terminal SP1-4 fragment (Arg-Pro-Lys-Pro) suppressed the response at a dose of 0.1 microgram/ml, but stimulated it slightly at higher doses (1-5 micrograms/ml).	Proline	48-51	Sp1 transcription factor	Homo sapiens	28-33
2293019-4	1990	The deduced amino acid sequence of pALP is 68% similar in primary structure to that of human ALP, is cysteine and proline rich, and exhibits a two-domain structure which, in the human protein, is involved in binding trypsin/cathepsin-G and elastase, respectively.	Proline	114-121	alkaline phosphatase, placental	Homo sapiens	35-39
2176822-6	1990	These results suggest that at least some of the sites phosphorylated by MFPK (BT of ATP-citrate lyase, Thr 72 of inhibitor 2, and sites 3b and 4 of glycogen synthase) contain a Ser/Thr flanked by a carboxyl-terminal proline.	Proline	216-223	ATP citrate lyase	Homo sapiens	84-101
2365193-6	1990	After 24 hours exposure to the transforming growth factor beta 1, cellular collagen synthesis was determined by the uptake of [3H]proline into collagenase-sensitive protein.	Proline	130-137	transforming growth factor beta 1	Homo sapiens	31-64
2115117-7	1990	The first reading frame of the 3.0-kb mRNA, called sur (for src upstream region), encoded a 24-kilodalton (kDa) protein product rich in cysteine and proline residues.	Proline	149-156	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	60-63
1698454-3	1990	Comparison of the amino acid sequences of RNase and angiogenin reveals several striking differences in the region flanking the active-site lysine, including a deletion and a transposition of aspartic acid and proline residues.	Proline	209-216	ribonuclease A family member k6	Gallus gallus	52-62
1698454-4	1990	In order to examine how these sequence changes alter the functional properties of angiogenin, an angiogenin/RNase hybrid protein (ARH-II), in which residues 38-41 of angiogenin (Pro-Cys-Lys-Asp) have been replaced by the corresponding segment of bovine pancreatic RNase (Asp-Arg-Cys-Lys-Pro), was prepared by regional mutagenesis.	Proline	178-181	ribonuclease A family member k6	Gallus gallus	82-92
2379952-13	1990	The amino acid profile of the two peptides was dominated by high levels of threonine, serine, and proline, which combined accounted for nearly 39% of the total residues, and in most respects, the profile resembled that of native mucin.	Proline	98-105	LOC100508689	Homo sapiens	229-234
2196384-7	1990	At the Tyr/Pro site in gag, processing was severely inhibited by substitutions within the P4, P2, P1, and P2" positions.	Proline	11-14	solute carrier family 10 member 4	Homo sapiens	90-108
2125702-5	1990	Infusion of a potent LHRH antagonist analogue [Ac-dehydro, Pro, pCl, D-Phe, DTrp]-LHRH, into the VMH significantly reduced the lordosis-to-mount ratio in animals subsequently treated with the LHRH decapeptide, but had no significant effect on lordotic behavior when the animals were subsequently infused with the Ac-LHRH fragment.	Proline	59-62	gonadotropin releasing hormone 1	Rattus norvegicus	21-25
2125702-5	1990	Infusion of a potent LHRH antagonist analogue [Ac-dehydro, Pro, pCl, D-Phe, DTrp]-LHRH, into the VMH significantly reduced the lordosis-to-mount ratio in animals subsequently treated with the LHRH decapeptide, but had no significant effect on lordotic behavior when the animals were subsequently infused with the Ac-LHRH fragment.	Proline	59-62	gonadotropin releasing hormone 1	Rattus norvegicus	82-86
2293019-4	1990	The deduced amino acid sequence of pALP is 68% similar in primary structure to that of human ALP, is cysteine and proline rich, and exhibits a two-domain structure which, in the human protein, is involved in binding trypsin/cathepsin-G and elastase, respectively.	Proline	114-121	secretory leukocyte peptidase inhibitor	Homo sapiens	36-39
2125702-5	1990	Infusion of a potent LHRH antagonist analogue [Ac-dehydro, Pro, pCl, D-Phe, DTrp]-LHRH, into the VMH significantly reduced the lordosis-to-mount ratio in animals subsequently treated with the LHRH decapeptide, but had no significant effect on lordotic behavior when the animals were subsequently infused with the Ac-LHRH fragment.	Proline	59-62	gonadotropin releasing hormone 1	Rattus norvegicus	82-86
2125702-5	1990	Infusion of a potent LHRH antagonist analogue [Ac-dehydro, Pro, pCl, D-Phe, DTrp]-LHRH, into the VMH significantly reduced the lordosis-to-mount ratio in animals subsequently treated with the LHRH decapeptide, but had no significant effect on lordotic behavior when the animals were subsequently infused with the Ac-LHRH fragment.	Proline	59-62	gonadotropin releasing hormone 1	Rattus norvegicus	82-86
2379503-6	1990	The serum proteins alpha-2 HS glycoprotein, gamma-globulin and fetuin, and the proline-rich salivary protein termed P-B were also identified in the enamelin extract.	Proline	79-86	enamelin	Bos taurus	148-156
2116976-4	1990	This is analogous to the Gln-Gln-Pro repeat in the C-terminal region of TraD product encoded on the R100 plasmid in Escherichia coli.	Proline	33-36	type IV conjugative transfer system couplingprotein TraD	Escherichia coli	72-76
1972707-1	1990	Prolidase (peptidase D) catalyzes hydrolysis of the di- and tripeptide with carboxyl-terminal proline and plays an important role in recycling proline in various cells and tissues.	Proline	94-101	peptidase D	Homo sapiens	0-9
1972707-1	1990	Prolidase (peptidase D) catalyzes hydrolysis of the di- and tripeptide with carboxyl-terminal proline and plays an important role in recycling proline in various cells and tissues.	Proline	94-101	peptidase D	Homo sapiens	11-22
2114324-4	1990	This is analogous to the Gln-Gln-Pro repeat in the C-terminal region of TraD product encoded on the R100 plasmid in Escherichia coli.	Proline	33-36	type IV conjugative transfer system couplingprotein TraD	Escherichia coli	72-76
1972707-1	1990	Prolidase (peptidase D) catalyzes hydrolysis of the di- and tripeptide with carboxyl-terminal proline and plays an important role in recycling proline in various cells and tissues.	Proline	143-150	peptidase D	Homo sapiens	0-9
1972707-1	1990	Prolidase (peptidase D) catalyzes hydrolysis of the di- and tripeptide with carboxyl-terminal proline and plays an important role in recycling proline in various cells and tissues.	Proline	143-150	peptidase D	Homo sapiens	11-22
2373079-2	1990	Based on the liberation of proline from ProLeuGlyNH2 (MIF-1, melanostatin) manganese-activated prolyl aminopeptidase activities were purified from rat brain and kidney cytosolic fractions.	Proline	27-34	leucine aminopeptidase 3	Rattus norvegicus	95-116
2164929-1	1990	We have recently described an insulin-resistant patient with leprechaunism (leprechaun G.) having a homozygous leucine----proline mutation at amino acid position 233 in the alpha-chain of the insulin receptor.	Proline	122-129	insulin	Homo sapiens	30-37
2164929-1	1990	We have recently described an insulin-resistant patient with leprechaunism (leprechaun G.) having a homozygous leucine----proline mutation at amino acid position 233 in the alpha-chain of the insulin receptor.	Proline	122-129	insulin receptor	Homo sapiens	192-208
2201466-6	1990	In that gene, a C----A transversion in codon 23, resulting in a proline----histidine substitution has now been identified in 17 of 148 unrelated ADRP patients in the United States (Dryja et al.	Proline	64-71	perilipin 2	Homo sapiens	145-149
2372310-2	1990	The use of NMR methods to study conformational and dynamic aspects of the proline residues in the nonapeptide bradykinin is reviewed.	Proline	74-81	kininogen 1	Homo sapiens	110-120
2115643-4	1990	The exchange of either leucine 1, 3, or 5 of the leucine repeat of FOS B to a proline dramatically inhibits its association with JUN proteins.	Proline	78-85	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	67-72
2117583-2	1990	TRH derives from a 242-amino acid precursor protein, prepro-TRH, with six repetitive sequences of -Lys-Arg-Gln-His-Pro-Gly-Lys/Arg)-Arg- connected by hydrophobic linking sequences.	Proline	115-118	thyrotropin releasing hormone	Homo sapiens	0-3
2118634-1	1990	The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics.	Proline	155-158	thyrotropin releasing hormone	Homo sapiens	60-63
2118634-1	1990	The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics.	Proline	155-158	thyrotropin releasing hormone	Homo sapiens	60-63
2118634-1	1990	The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics.	Proline	155-158	thyrotropin releasing hormone	Homo sapiens	60-63
2118634-6	1990	Both His-Pro-NH2 and His-Pro degraded by first-order kinetics and faster than TRH, with half-lives of 5.3 and 2.2 min, respectively, in 80% plasma.	Proline	9-12	thyrotropin releasing hormone	Homo sapiens	78-81
2141335-2	1990	The spectrin-binding domain of ankyrin is comprised of two subdomains: an acidic, proline-rich region (pI = 4) involving the amino-terminal 80 residues from 828 to 908 and a basic region (pI = 8.8) that extends from 898 to 1386.	Proline	82-89	Ankyrin	Drosophila melanogaster	31-38
2351676-7	1990	The deduced CRS1C and CRS4C polypeptides are apparent precursors of secreted, cationic, proline- and cysteine-rich peptides that contain Cys-Pro-X repeats.	Proline	88-95	defensin, alpha, 29	Mus musculus	12-17
2351676-7	1990	The deduced CRS1C and CRS4C polypeptides are apparent precursors of secreted, cationic, proline- and cysteine-rich peptides that contain Cys-Pro-X repeats.	Proline	88-95	defensin, alpha, related sequence 2	Mus musculus	22-27
2118634-1	1990	The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics.	Proline	74-77	thyrotropin releasing hormone	Homo sapiens	60-63
2117583-3	1990	Antibodies to TRH-Gly (pGlu-His-Pro-Gly), a final precursor for TRH formation, were used to detect this tetrapeptide as well as other prepro-TRH fragments which cross-react with these antibodies.	Proline	32-35	thyrotropin releasing hormone	Homo sapiens	14-17
2117583-3	1990	Antibodies to TRH-Gly (pGlu-His-Pro-Gly), a final precursor for TRH formation, were used to detect this tetrapeptide as well as other prepro-TRH fragments which cross-react with these antibodies.	Proline	32-35	thyrotropin releasing hormone	Homo sapiens	64-67
2117583-3	1990	Antibodies to TRH-Gly (pGlu-His-Pro-Gly), a final precursor for TRH formation, were used to detect this tetrapeptide as well as other prepro-TRH fragments which cross-react with these antibodies.	Proline	32-35	thyrotropin releasing hormone	Homo sapiens	64-67
2117583-7	1990	A minor, TRH-Gly immunoreactive peak increased 50-fold (P less than 0.001) during 20 h at 60 degrees C. This material co-eluted with Arg-Gln-His-Pro-Gly which is formed by enzymic cleavage of the paired basic residues flanking this sequence in prepro-TRH.	Proline	145-148	thyrotropin releasing hormone	Homo sapiens	9-12
2117583-8	1990	When synthetic Arg-Gln-His-Pro-Gly was incubated with fresh semen at 60 degrees C a rapid conversion of most of this peptide to Glu-His-Pro-Gly, Gln-His-Pro-Gly and TRH-Gly occurred within 30 min.	Proline	27-30	thyrotropin releasing hormone	Homo sapiens	165-168
2190554-0	1990	Substitution of proline with pipecolic acid at the scissile bond converts a peptide substrate of HIV proteinase into a selective inhibitor.	Proline	16-23	endogenous retrovirus group K member 25	Homo sapiens	101-111
2114285-8	1990	The coding of the serine active-site residue together with the proacrosin-specific proline-rich domain in one exon, namely exon E5, let us assume that the nucleotide sequence for the proline-rich domain was generated during evolution by intron-exon transfer from a foreign gene with subsequent intron excision.	Proline	83-90	acrosin	Homo sapiens	63-73
2114285-8	1990	The coding of the serine active-site residue together with the proacrosin-specific proline-rich domain in one exon, namely exon E5, let us assume that the nucleotide sequence for the proline-rich domain was generated during evolution by intron-exon transfer from a foreign gene with subsequent intron excision.	Proline	183-190	acrosin	Homo sapiens	63-73
2162041-1	1990	Rat thyrotropin-releasing hormone (TRH) prohormone contains five copies of the TRH progenitor sequence Gln-His-Pro-Gly linked together by connecting sequences whose biological activity is unknown.	Proline	111-114	thyrotropin releasing hormone	Rattus norvegicus	4-33
2162041-1	1990	Rat thyrotropin-releasing hormone (TRH) prohormone contains five copies of the TRH progenitor sequence Gln-His-Pro-Gly linked together by connecting sequences whose biological activity is unknown.	Proline	111-114	thyrotropin releasing hormone	Rattus norvegicus	35-38
2162041-1	1990	Rat thyrotropin-releasing hormone (TRH) prohormone contains five copies of the TRH progenitor sequence Gln-His-Pro-Gly linked together by connecting sequences whose biological activity is unknown.	Proline	111-114	thyrotropin releasing hormone	Rattus norvegicus	79-82
2324739-1	1990	Five phosphate-dependent monoclonal antibodies to the neurofilament heavy polypeptide bound strongly to a phosphorylated synthetic peptide, which contains a single Lys-Ser-Pro sequence that occurs in human neurofilaments.	Proline	172-175	neurofilament heavy chain	Homo sapiens	54-85
2109688-2	1990	Two antisera (Anti-P7 and Anti-P10) were raised against (-Gln-His-Pro-Gly-) elongated peptides: P7 Gln-His-Pro-Gly-Lys-Arg-Phe) and P10 (Ser-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-Phe).	Proline	66-69	S100 calcium binding protein A10 (calpactin)	Mus musculus	31-34
2113484-2	1990	TRH-extended peptides have been detected in the rat olfactory lobe: these peptides accounted for approximately 11% of the total TRH immunoreactivity present in the tissue and contained the sequence pGlu-His-Pro-Gly-Arg exclusively at their N-termini.	Proline	207-210	thyrotropin releasing hormone	Rattus norvegicus	0-3
2350544-0	1990	The rate and structural consequences of proline cis-trans isomerization in calbindin D9k: NMR studies of the minor (cis-Pro43) isoform and the Pro43Gly mutant.	Proline	40-47	S100 calcium binding protein G	Homo sapiens	75-88
2350549-8	1990	Distance geometry calculations suggest that in the structure of the thrombin-bound hirudin peptides all the charged residues lie on the opposite side of a hydrophobic cluster formed by the nonpolar side chains of residues Phe(56), Ile(59), Pro(60), Tyr(63), and Leu(64).	Proline	240-243	coagulation factor II, thrombin	Bos taurus	68-76
2108963-11	1990	The tryptic phosphopeptide corresponds exactly to a sequence in the collagenase-sensitive, proline-rich "tail" region of bovine synapsin I.	Proline	91-98	synapsin-1	Bos taurus	128-138
2185035-1	1990	The calcium-binding protein calbindin D9k has previously been shown to exist in two folded forms only differing in the proline cis-trans isomerism of the Gly-42-Pro-43 amide bond.	Proline	119-126	S100 calcium binding protein G	Homo sapiens	28-41
2185035-1	1990	The calcium-binding protein calbindin D9k has previously been shown to exist in two folded forms only differing in the proline cis-trans isomerism of the Gly-42-Pro-43 amide bond.	Proline	161-164	S100 calcium binding protein G	Homo sapiens	28-41
2138707-5	1990	The inferred amino acid sequence of mXBP shows near identity to human CRE-BP1, except it does not contain an internal proline-rich domain.	Proline	118-125	activating transcription factor 2	Mus musculus	36-40
2107882-3	1990	Only one difference was observed; a thymidine at the first position of codon 127 (TCT) was altered to a cytidine in the b5R gene of the patient, resulting in replacement of serine with proline.	Proline	185-192	cytochrome b5 reductase 3	Homo sapiens	120-123
2318143-2	1990	Continuous treatment with PTHrp for 24-72 h stimulated DNA synthesis, but inhibited [3H] proline incorporation into collagen by about 50%.	Proline	89-96	parathyroid hormone-like hormone	Rattus norvegicus	26-31
2318143-3	1990	In contrast, transient exposure to PTHrp at 0.1-1.0 nM for 24 h followed by removal of the factor for 48 h caused an increase in [3H]proline incorporation into collagen and noncollagen protein by 2- and 1.6-fold, respectively.	Proline	133-140	parathyroid hormone-like hormone	Rattus norvegicus	35-40
1689609-2	1990	We have made a mutein of human G-CSF, KW-2228, in which Thr-1, Leu-3, Gly-4, Pro-5, and Cys-17 were respectively substituted with Ala, Thr, Tyr, Arg, and Ser; showed more potent G-CSF activity; and retained full biological activity and receptor binding capacity at least 2 weeks of radioiodination.	Proline	77-80	colony stimulating factor 3	Homo sapiens	31-36
2186807-4	1990	Renin pH dependence was evaluated between pH 4.0 and 8.0 by using a synthetic substrate identical with the amino terminus of porcine angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu*Leu-Val-Tyr-Ser, where the asterisk indicates the scissile peptide bond and the proximal histidine is in italics) and an analogous tetradecapeptide where the proximal histidine was substituted with glutamine.	Proline	174-177	renin	Homo sapiens	0-5
2156268-5	1990	Both BAT2 and BAT3 are very rich in proline and include short tracts of polyproline, polyglycine, and charged amino acids.	Proline	36-43	proline rich coiled-coil 2A	Homo sapiens	5-9
2318210-10	1990	Anhydrotrypsin affinity chromatography of trypsin-digested rCD4 confirmed that the carboxy-terminus of the protein was Pro-368.	Proline	119-122	Cd4 molecule	Rattus norvegicus	59-63
2106377-3	1990	At 96 hours, heparin 5, 25, and 125 micrograms/ml decreased [3H]proline incorporation into CDP by 41, 48, and 32%, respectively, with no significant change in NCP.	Proline	64-71	cut-like homeobox 1	Rattus norvegicus	91-94
2106377-6	1990	At 96 hours, indomethacin (10(-6) M) inhibited [3H]-proline incorporation into CDP by 38% but had no effect on the labeling of NCP.	Proline	52-59	cut-like homeobox 1	Rattus norvegicus	79-82
2155107-1	1990	Previous studies have shown that prostaglandin E2 (PGE2) has both inhibitory and stimulatory effects on the incorporation of proline into collagenase-digestible protein (CDP) in cultured fetal rat calvaria.	Proline	125-132	cut-like homeobox 1	Rattus norvegicus	170-173
2156268-5	1990	Both BAT2 and BAT3 are very rich in proline and include short tracts of polyproline, polyglycine, and charged amino acids.	Proline	36-43	BAG cochaperone 6	Homo sapiens	14-18
2156268-7	1990	BAT2 and BAT3 are similar to other proteins with large proline-rich domains, such as some nuclear proteins, collagens, elastin, and synapsin.	Proline	55-62	proline rich coiled-coil 2A	Homo sapiens	0-4
2156268-7	1990	BAT2 and BAT3 are similar to other proteins with large proline-rich domains, such as some nuclear proteins, collagens, elastin, and synapsin.	Proline	55-62	BAG cochaperone 6	Homo sapiens	9-13
2302733-3	1990	To activate transcription, Oct-2 relies on two interdependent nonacidic domains, an N-terminal glutamine-rich region and a C-terminal serine-, threonine-, and proline-rich region.	Proline	159-166	POU class 2 homeobox 2	Homo sapiens	27-32
1967980-8	1990	The N-terminal proline-rich region of Oct-3, when fused to the DNA binding domain of c-Jun, functions as a transcriptional activating domain.	Proline	15-22	POU domain, class 5, transcription factor 1	Mus musculus	38-43
1967980-8	1990	The N-terminal proline-rich region of Oct-3, when fused to the DNA binding domain of c-Jun, functions as a transcriptional activating domain.	Proline	15-22	jun proto-oncogene	Mus musculus	85-90
2406252-4	1990	N-Terminal sequencing has revealed that all three forms start with proline, which is the second amino acid expected from the RAS2 gene sequence.	Proline	67-74	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	125-129
1968318-7	1990	CGRP primarily evoked release of peptides measured collectively as Pro-S, S-14, and S-13 into venous blood draining the fundus and corpus, and concentrations were significantly elevated above basal at 0.8 and 1.6 micrograms.kg-1.h-1 CGRP (P less than 0.05).	Proline	67-70	calcitonin related polypeptide alpha	Homo sapiens	0-4
2303168-2	1990	The longest open reading frame encodes a polypeptide 143 amino acids long which contains 21% cysteine and 27% proline and closely resembles the size and amino acid composition of bull mitochondrial capsule seleno-protein (V. Pallini, B. Baccetti, and A. G. Burrini, 1979, in "The Spermatozoon," D. W. Fawcett and J. M. Bedford, Eds., pp.	Proline	110-117	sperm mitochondria-associated cysteine-rich protein	Mus musculus	184-220
2305876-3	1990	Histomorphometric analysis of caudal vertebrae showed that EGF (20 and 200 ng.g-1.day-1) reduced the endosteal matrix and mineral appositional rates after 5 days of treatment as measured by double [3H]proline labeling and double tetracycline labeling, respectively.	Proline	201-208	epidermal growth factor	Mus musculus	59-62
2153246-3	1990	This fragment is rich in proline and acidic amino acids and sheds into the cytoplasm, where it appears to accumulate, being present in a six- to sevenfold molar excess over p63/LMP in immunoprecipitation analyses.	Proline	25-32	PDZ and LIM domain 7	Homo sapiens	177-180
2323886-6	1990	Whereas the conformation of the Gla-21 Pro-22 amide bond remains decidedly trans in the absence of the model head group, in its presence, the cis Ca(II) ion induced (but not Mg(II] form is significantly lowered in relative energy.	Proline	39-42	carbonic anhydrase 2	Bos taurus	146-152
1691155-3	1990	The corresponding proline-containing glycopeptide incorporating a beta-D-glucopyranosyl residue linked to the side-chain of Glu6 was 100 times more selective than Substance P for the same receptor.	Proline	18-25	tachykinin precursor 1	Homo sapiens	163-174
2104621-5	1990	This interdomain region contains the sequence ...Asn-Tyr-Pro-Thr... which is similar to that surrounding the scissile Tyr-Pro bond in the gag precursor polyprotein, a natural substrate of the HIV-1 protease.	Proline	57-60	Pr55(Gag)	Human immunodeficiency virus 1	138-141
1967253-0	1990	Hydrolysis and transport of proline-containing peptides in renal brush-border membrane vesicles from dipeptidyl peptidase IV-positive and dipeptidyl peptidase IV-negative rat strains.	Proline	28-35	dipeptidylpeptidase 4	Rattus norvegicus	101-124
1967253-6	1990	Urine analysis revealed that the DPP IV-negative rats excreted proline- and hydroxyproline-containing peptides in significantly increased amounts in their urine compared with control rats.	Proline	63-70	dipeptidylpeptidase 4	Rattus norvegicus	33-39
1967253-8	1990	These data provide conclusive evidence for the obligatory role of DPP IV in the renal handling of proline (and hydroxyproline)-containing peptides.	Proline	98-105	dipeptidylpeptidase 4	Rattus norvegicus	66-72
2329998-3	1990	Collagen synthesis was assessed as [3H]proline incorporation into collagenase-digestible protein (CDP).	Proline	39-46	cut-like homeobox 1	Mus musculus	66-96
2323714-5	1990	Sequence comparison of both b5R genes indicated that a thymidine at first position of codon 127 was altered to a cytidine, resulting in replacement of serine with proline.	Proline	163-170	cytochrome b5 reductase 3	Homo sapiens	28-31
2331431-1	1990	We tested the effect of ethanol and its metabolite, acetaldehyde, on bone formation as measured by [3H]proline incorporation into collagenase digestible protein (CDP) and noncollagen protein (NCP), and on DNA synthesis as measured by [3H]thymidine (TdR) incorporation in fetal rat calvaria.	Proline	103-110	cut-like homeobox 1	Rattus norvegicus	130-160
2331431-1	1990	We tested the effect of ethanol and its metabolite, acetaldehyde, on bone formation as measured by [3H]proline incorporation into collagenase digestible protein (CDP) and noncollagen protein (NCP), and on DNA synthesis as measured by [3H]thymidine (TdR) incorporation in fetal rat calvaria.	Proline	103-110	cut-like homeobox 1	Rattus norvegicus	162-165
2331431-10	1990	At 0.01% and 0.03% acetaldehyde inhibited proline incorporation into CDP by 48% and 94% and NCP by 40% and 74% respectively.	Proline	42-49	cut-like homeobox 1	Rattus norvegicus	69-72
33941685-6	2021	NMR structural analysis of the AKAP binding domain reveals a compact shape with several proline-driven turns.	Proline	88-95	A-kinase anchoring protein 1	Homo sapiens	31-35
2139224-3	1990	The consensus peptide for each is rhodopsin Tyr Pro Pro Gln Gly synaptophysin Tyr Gly Pro Gln Gly synexin Tyr Pro Pro Pro Pro Gly gliadin Tyr Pro Pro Pro Gln Pro RNA polymerase II Tyr Ser Pro Thr Ser Pro Ser hordein Phe Pro Gln Gln Pro Gln Gln Pro gluten Tyr Pro Thr Ser Pro Gln Gln Gly Tyr Although there is obvious variation of sequence and of length, the penta- to nonapeptides share an initial Tyr (or Phe) and have high Pro contents and abundant Gly, Gln, and Ser.	Proline	48-51	rhodopsin	Homo sapiens	34-43
2139224-3	1990	The consensus peptide for each is rhodopsin Tyr Pro Pro Gln Gly synaptophysin Tyr Gly Pro Gln Gly synexin Tyr Pro Pro Pro Pro Gly gliadin Tyr Pro Pro Pro Gln Pro RNA polymerase II Tyr Ser Pro Thr Ser Pro Ser hordein Phe Pro Gln Gln Pro Gln Gln Pro gluten Tyr Pro Thr Ser Pro Gln Gln Gly Tyr Although there is obvious variation of sequence and of length, the penta- to nonapeptides share an initial Tyr (or Phe) and have high Pro contents and abundant Gly, Gln, and Ser.	Proline	48-51	synaptophysin	Homo sapiens	64-77
2139224-3	1990	The consensus peptide for each is rhodopsin Tyr Pro Pro Gln Gly synaptophysin Tyr Gly Pro Gln Gly synexin Tyr Pro Pro Pro Pro Gly gliadin Tyr Pro Pro Pro Gln Pro RNA polymerase II Tyr Ser Pro Thr Ser Pro Ser hordein Phe Pro Gln Gln Pro Gln Gln Pro gluten Tyr Pro Thr Ser Pro Gln Gln Gly Tyr Although there is obvious variation of sequence and of length, the penta- to nonapeptides share an initial Tyr (or Phe) and have high Pro contents and abundant Gly, Gln, and Ser.	Proline	48-51	annexin A7	Homo sapiens	98-105
283390-0	1978	Acid catalysis of the formation of the slow-folding species of RNase A: evidence that the reaction is proline isomerization.	Proline	102-109	ribonuclease A family member 1, pancreatic	Homo sapiens	63-70
283390-10	1978	Earlier data, showing that the kinetic properties of the U(1) right arrow over left arrow U(2) reaction in refolding conditions differ from those of proline isomerization, can be explained if there is kinetic coupling between early steps in the folding of U(1) and its conversion to U(2).The existence of two acid-catalyzed reactions that are distinguished by the HClO(4) concentration at which catalysis begins suggests that at least two essential proline residues produce slow-folding species of RNase A by isomerization after unfolding.	Proline	149-156	ribonuclease A family member 1, pancreatic	Homo sapiens	498-505
283390-10	1978	Earlier data, showing that the kinetic properties of the U(1) right arrow over left arrow U(2) reaction in refolding conditions differ from those of proline isomerization, can be explained if there is kinetic coupling between early steps in the folding of U(1) and its conversion to U(2).The existence of two acid-catalyzed reactions that are distinguished by the HClO(4) concentration at which catalysis begins suggests that at least two essential proline residues produce slow-folding species of RNase A by isomerization after unfolding.	Proline	449-456	ribonuclease A family member 1, pancreatic	Homo sapiens	498-505
2298447-5	1990	At the C-terminal end, a proline-rich sequence is present in both species; this may represent the species-specificity of acrosin.	Proline	25-32	acrosin	Homo sapiens	121-128
2181240-5	1990	The same principle was found to apply to TraT of R6-5: the introduction, by site-directed mutagenesis, of either positively or negatively charged amino acids or the helix-disrupting proline in the corresponding hydrophobic region led to increased hydrophobic permeability of the outer membrane.	Proline	182-189	TraT	Salmonella enterica subsp. enterica serovar Typhimurium	41-45
2100004-1	1990	Conformation of the renin inhibitor peptide, Pro-His-Pro-Phe-His-Phe-Phe-Val-Tyr-Lys (RIP) has been studied in aqueous solution and in lipid bilayers using 500 MHz 1H NMR spectroscopy.	Proline	45-48	renin	Homo sapiens	20-25
2133944-5	1990	Amino acid analysis of dentine showed apparent differences among these groups in the degrees of hydroxylation of proline (Hyp/Pro + Hyp) and of lysine (Hyl/Lys + Hyl).	Proline	113-120	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	122-125
2133944-5	1990	Amino acid analysis of dentine showed apparent differences among these groups in the degrees of hydroxylation of proline (Hyp/Pro + Hyp) and of lysine (Hyl/Lys + Hyl).	Proline	113-120	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	132-135
33807199-1	2021	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function.	Proline	132-139	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-54
33799176-3	2021	Three aaRS inhibitors are already in clinical practice; antibacterial mupirocin inhibits the synthetic site of isoleucyl-tRNA synthetase, antifungal tavaborole inhibits the editing site of leucyl-tRNA synthetase, and antiprotozoal halofuginone inhibits proline-tRNA synthetase.	Proline	253-260	alanyl-tRNA synthetase 1	Homo sapiens	6-10
33799176-3	2021	Three aaRS inhibitors are already in clinical practice; antibacterial mupirocin inhibits the synthetic site of isoleucyl-tRNA synthetase, antifungal tavaborole inhibits the editing site of leucyl-tRNA synthetase, and antiprotozoal halofuginone inhibits proline-tRNA synthetase.	Proline	253-260	isoleucyl-tRNA synthetase 1	Homo sapiens	111-136
33771508-1	2021	Pyrroline-5-carboxylate reductase (PYCR in humans) catalyzes the final step of l-proline biosynthesis by catalyzing the reduction of L-Delta1-pyrroline-5-carboxylate (L-P5C) to l-proline using NAD(P)H as the hydride donor.	Proline	79-88	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-39
33771508-1	2021	Pyrroline-5-carboxylate reductase (PYCR in humans) catalyzes the final step of l-proline biosynthesis by catalyzing the reduction of L-Delta1-pyrroline-5-carboxylate (L-P5C) to l-proline using NAD(P)H as the hydride donor.	Proline	177-186	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-39
33818628-2	2021	The process is catalysed by proline dehydrogenase/proline oxidase (PRODH/POX), a mitochondrial flavin-dependent enzyme converting proline into  1-pyrroline-5-carboxylate (P5C).	Proline	28-35	proline dehydrogenase 1	Homo sapiens	67-72
33818628-2	2021	The process is catalysed by proline dehydrogenase/proline oxidase (PRODH/POX), a mitochondrial flavin-dependent enzyme converting proline into  1-pyrroline-5-carboxylate (P5C).	Proline	28-35	proline dehydrogenase 1	Homo sapiens	73-76
33818628-6	2021	Proline availability is regulated by prolidase (proline supporting enzyme), collagen biosynthesis (proline utilizing process) and proline synthesis from glutamine, glutamate, alpha-ketoglutarate (alpha-KG) and ornithine.	Proline	0-7	peptidase D	Homo sapiens	37-46
33818628-11	2021	These aspects of proline metabolism are discussed in the review as an approach to understand complex regulatory mechanisms driving PRODH/POX-dependent apoptosis/survival.	Proline	17-24	proline dehydrogenase 1	Homo sapiens	131-136
33818628-11	2021	These aspects of proline metabolism are discussed in the review as an approach to understand complex regulatory mechanisms driving PRODH/POX-dependent apoptosis/survival.	Proline	17-24	proline dehydrogenase 1	Homo sapiens	137-140
33794133-0	2021	Interaction between the guanylate kinase domain of PSD-95 and the proline-rich region and microtubule binding repeats 2 and 3 of tau.	Proline	66-73	guanylate kinase 1	Homo sapiens	24-40
33794133-0	2021	Interaction between the guanylate kinase domain of PSD-95 and the proline-rich region and microtubule binding repeats 2 and 3 of tau.	Proline	66-73	discs large MAGUK scaffold protein 4	Homo sapiens	51-57
33794133-7	2021	Mapping the interaction of the MAGUK core on tau revealed the microtubule binding repeats 2 and 3 and the proline-rich region contribute to this interaction, while the N- and C-terminal regions of tau inhibit interaction.	Proline	106-113	microtubule associated protein tau	Homo sapiens	45-48
33807199-1	2021	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function.	Proline	132-139	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	56-60
33771996-4	2021	We localize the key determinants of phospho-Bora function to a 100 amino acid region encompassing two short Tpx2-like motifs and a phosphoSerine-Proline motif at Serine 112, through which Bora binds AURKA.	Proline	145-152	BORA aurora kinase A activator	Homo sapiens	44-48
33771996-4	2021	We localize the key determinants of phospho-Bora function to a 100 amino acid region encompassing two short Tpx2-like motifs and a phosphoSerine-Proline motif at Serine 112, through which Bora binds AURKA.	Proline	145-152	BORA aurora kinase A activator	Homo sapiens	188-192
33771996-4	2021	We localize the key determinants of phospho-Bora function to a 100 amino acid region encompassing two short Tpx2-like motifs and a phosphoSerine-Proline motif at Serine 112, through which Bora binds AURKA.	Proline	145-152	aurora kinase A	Homo sapiens	199-204
33802361-5	2021	Another mutation, T755C, is a T-to-C base change at position 755 of exon 2, resulting in leucine replacement by proline at this position of the BMP15 protein (p.L252P).	Proline	112-119	bone morphogenetic protein 15	Ovis aries	144-149
33761308-2	2021	We show here that the levels of kindlin-2 and its binding partner PYCR1, a key enzyme for proline synthesis, are significantly increased in the lung tissues of human patients with pulmonary fibrosis.	Proline	90-97	FERM domain containing kindlin 2	Homo sapiens	32-41
33761308-2	2021	We show here that the levels of kindlin-2 and its binding partner PYCR1, a key enzyme for proline synthesis, are significantly increased in the lung tissues of human patients with pulmonary fibrosis.	Proline	90-97	pyrroline-5-carboxylate reductase 1	Homo sapiens	66-71
33761308-3	2021	Treatment of human lung fibroblasts with TGF-beta1 markedly increased the expression of kindlin-2 and PYCR1, resulting in increased kindlin-2 mitochondrial translocation, formation of the kindlin-2-PYCR1 complex and proline synthesis.	Proline	216-223	transforming growth factor beta 1	Homo sapiens	41-50
33761308-3	2021	Treatment of human lung fibroblasts with TGF-beta1 markedly increased the expression of kindlin-2 and PYCR1, resulting in increased kindlin-2 mitochondrial translocation, formation of the kindlin-2-PYCR1 complex and proline synthesis.	Proline	216-223	FERM domain containing kindlin 2	Homo sapiens	88-97
33761308-3	2021	Treatment of human lung fibroblasts with TGF-beta1 markedly increased the expression of kindlin-2 and PYCR1, resulting in increased kindlin-2 mitochondrial translocation, formation of the kindlin-2-PYCR1 complex and proline synthesis.	Proline	216-223	pyrroline-5-carboxylate reductase 1	Homo sapiens	102-107
33761308-5	2021	Furthermore, depletion of kindlin-2 alone was sufficient to suppress TGF-beta1-induced increases of PYCR1 expression, proline synthesis and fibroblast activation.	Proline	118-125	FERM domain containing kindlin 2	Homo sapiens	26-35
33761308-5	2021	Furthermore, depletion of kindlin-2 alone was sufficient to suppress TGF-beta1-induced increases of PYCR1 expression, proline synthesis and fibroblast activation.	Proline	118-125	transforming growth factor beta 1	Homo sapiens	69-78
33761308-6	2021	Finally, using a bleomycin mouse model of pulmonary fibrosis, we show that ablation of kindlin-2 effectively reduced the levels of PYCR1, proline and collagen matrix and alleviate the progression of pulmonary fibrosis in vivo.	Proline	138-145	fermitin family member 2	Mus musculus	87-96
33805821-10	2021	Taken together, we suggest that AtBBD1 functions as a novel positive regulator of drought responses by enhancing the expression of ABA- and drought stress-responsive genes as well as by increasing proline content.	Proline	197-204	bifunctional nuclease in basal defense response 1	Arabidopsis thaliana	32-38
33801906-5	2021	Furthermore, Env was stabilized on the VLP surface by introducing an interchain disulfide and proline substitution (SOSIP) mutations typically employed to stabilize soluble Env trimers.	Proline	94-101	melanoma antigen	Mus musculus	13-16
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Proline	213-220	aldehyde dehydrogenase 18 family member A1	Homo sapiens	16-24
33820739-4	2021	We report the occurrence of a novel mutation at 323aa (314aa of orf1b) of nsp12 (RNA-dependent RNA polymerase) changed to phenylalanine (F) from proline (P), in the first reported isolate of SARS-CoV-2, Wuhan-Hu-1.	Proline	145-152	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	64-69
33591178-0	2021	p53 Is Potentially Regulated by Cyclophilin D in the Triple-Proline Loop of the DNA Binding Domain.	Proline	60-67	tumor protein p53	Homo sapiens	0-3
33591178-0	2021	p53 Is Potentially Regulated by Cyclophilin D in the Triple-Proline Loop of the DNA Binding Domain.	Proline	60-67	peptidylprolyl isomerase D	Homo sapiens	32-45
33591178-6	2021	We have identified the specific cyclophilin D binding site on p53 that is located at proline 151 in the DNA binding domain.	Proline	85-92	peptidylprolyl isomerase D	Homo sapiens	32-45
33591178-6	2021	We have identified the specific cyclophilin D binding site on p53 that is located at proline 151 in the DNA binding domain.	Proline	85-92	tumor protein p53	Homo sapiens	62-65
33591178-7	2021	As a peptidyl-prolyl isomerase, cyclophilin D binds p53 and catalyzes the cis-trans isomerization of the peptide bond preceding proline 151.	Proline	128-135	peptidylprolyl isomerase D	Homo sapiens	32-45
33591178-7	2021	As a peptidyl-prolyl isomerase, cyclophilin D binds p53 and catalyzes the cis-trans isomerization of the peptide bond preceding proline 151.	Proline	128-135	tumor protein p53	Homo sapiens	52-55
33591178-8	2021	We have also characterized the effect of such an isomerization and found that the p53 domain in the cis state is overall more rigid than the trans state except for the local region around proline 151.	Proline	188-195	tumor protein p53	Homo sapiens	82-85
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Proline	213-220	aldehyde dehydrogenase 18 family member A1	Homo sapiens	64-106
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Proline	213-220	aldehyde dehydrogenase 18 family member A1	Homo sapiens	108-112
33236008-4	2020	Here we show that this RBD conjugated to each of two carrier proteins elicited more potent neutralizing responses in immunized rodents than did a similarly conjugated proline-stabilized S-protein ectodomain.	Proline	167-174	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	186-187
33233403-4	2020	We generated a recombinant HSV expressing a completely retargeted glycoprotein D (gD), the viral attachment/entry protein, that incorporates pre-pro-GDNF in place of the signal peptide and HVEM binding domain of gD and contains a deletion of amino acid 38 to eliminate nectin-1 binding.	Proline	71-74	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	82-84
33233403-4	2020	We generated a recombinant HSV expressing a completely retargeted glycoprotein D (gD), the viral attachment/entry protein, that incorporates pre-pro-GDNF in place of the signal peptide and HVEM binding domain of gD and contains a deletion of amino acid 38 to eliminate nectin-1 binding.	Proline	71-74	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	212-214
33233403-4	2020	We generated a recombinant HSV expressing a completely retargeted glycoprotein D (gD), the viral attachment/entry protein, that incorporates pre-pro-GDNF in place of the signal peptide and HVEM binding domain of gD and contains a deletion of amino acid 38 to eliminate nectin-1 binding.	Proline	71-74	nectin cell adhesion molecule 1	Homo sapiens	269-277
26997627-4	2016	The oxygen-sensing PHDs regulate the stability of hypoxia-inducible factor 1alpha (HIF1alpha) as well as other proline-containing proteins by catalyzing the hydroxylation of proline residues.	Proline	111-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-81
26997627-4	2016	The oxygen-sensing PHDs regulate the stability of hypoxia-inducible factor 1alpha (HIF1alpha) as well as other proline-containing proteins by catalyzing the hydroxylation of proline residues.	Proline	111-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-92
26997627-4	2016	The oxygen-sensing PHDs regulate the stability of hypoxia-inducible factor 1alpha (HIF1alpha) as well as other proline-containing proteins by catalyzing the hydroxylation of proline residues.	Proline	174-181	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-81
26997627-4	2016	The oxygen-sensing PHDs regulate the stability of hypoxia-inducible factor 1alpha (HIF1alpha) as well as other proline-containing proteins by catalyzing the hydroxylation of proline residues.	Proline	174-181	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-92
23562579-1	2013	Prolyl oligopeptidase (EC 3.4.21.26, PREP) is a serine protease that hydrolyzes proline-containing peptides shorter than 30-mer but it has also nonhydrolytic functions.	Proline	80-87	prolyl endopeptidase	Homo sapiens	0-21
26306868-0	2015	Human cathepsin L, a papain-like collagenase without proline specificity.	Proline	53-60	cathepsin L	Homo sapiens	6-17
26628999-4	2015	We also found that vitamin C could increase the proline hydroxylation of HIF-1alpha and reduce the activity of HIF-1alpha.	Proline	48-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-83
26628999-6	2015	Overexpression of wild-type HIF-1alpha or proline-mutant HIF-1alpha was found to increase the proliferation and migration of human lens epithelial cells.	Proline	42-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-67
23266121-3	2013	In order to solve this problem and to obtain further potent compounds, we executed medicinal research and thus furnished the optimal compounds by incorporating the methyl group onto the C-6 position to avoid the oxidation, and by modifying the C-2 moiety of the additional proline motif, which furnished high potency.	Proline	273-280	complement C2	Homo sapiens	244-247
23562579-1	2013	Prolyl oligopeptidase (EC 3.4.21.26, PREP) is a serine protease that hydrolyzes proline-containing peptides shorter than 30-mer but it has also nonhydrolytic functions.	Proline	80-87	prolyl endopeptidase	Homo sapiens	37-41
19360098-4	2009	The rat IAPP variants with three proline residues maintain unstructured micelle-like oligomers, which is consistent with non-amyloidogenic behavior observed in experimental studies.	Proline	33-40	islet amyloid polypeptide	Rattus norvegicus	8-12
22275353-6	2012	We further show that AIP4 and STAM-1 physically interact and that the proline-rich region in AIP4 and the SH3 domain in STAM-1 are essential for the interaction.	Proline	70-77	signal transducing adaptor molecule	Homo sapiens	30-36
22275353-6	2012	We further show that AIP4 and STAM-1 physically interact and that the proline-rich region in AIP4 and the SH3 domain in STAM-1 are essential for the interaction.	Proline	70-77	itchy E3 ubiquitin protein ligase	Homo sapiens	93-97
22275353-6	2012	We further show that AIP4 and STAM-1 physically interact and that the proline-rich region in AIP4 and the SH3 domain in STAM-1 are essential for the interaction.	Proline	70-77	signal transducing adaptor molecule	Homo sapiens	120-126
22670809-8	2012	We determined the structures of Pin1 bound with two substrate isosteres that mimic peptides containing pSer/Thr-Pro motifs in cis or trans conformations.	Proline	112-115	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	32-36
22670809-10	2012	Building on this result, we identified a specific case in which Pin1 differentially affects the rate of dephosphorylation catalyzed by two phosphatases (Scp1 and Ssu72) that target the same serine residue in the CTD heptad repeat but have different preferences for the isomerization state of the adjacent proline residue.	Proline	305-312	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	64-68
22670809-10	2012	Building on this result, we identified a specific case in which Pin1 differentially affects the rate of dephosphorylation catalyzed by two phosphatases (Scp1 and Ssu72) that target the same serine residue in the CTD heptad repeat but have different preferences for the isomerization state of the adjacent proline residue.	Proline	305-312	CTD small phosphatase 1	Homo sapiens	153-157
22670809-10	2012	Building on this result, we identified a specific case in which Pin1 differentially affects the rate of dephosphorylation catalyzed by two phosphatases (Scp1 and Ssu72) that target the same serine residue in the CTD heptad repeat but have different preferences for the isomerization state of the adjacent proline residue.	Proline	305-312	SSU72 homolog, RNA polymerase II CTD phosphatase	Homo sapiens	162-167
16319069-5	2006	We demonstrated by both gain and loss of function studies for the serotonin 2C, beta2-adrenergic, alpha2a)adrenergic, and neuropeptide Y type 2 receptors that the highly conserved amino acids, proline and alanine, naturally occurring in rhodopsin family receptors six residues distal to the highly conserved second loop DRY motif regulate beta-arrestin binding and beta-arrestin-mediated internalization.	Proline	193-200	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	80-85
34583165-4	2022	SNP suppressed Cr-triggered proline accumulation by inhibiting Delta1-pyrroline-5-carboxylate synthetase activity and stimulating proline dehydrogenase activity, leading to glutamate over-accumulation (~30% for both organs).	Proline	28-35	Delta-1-pyrroline-5-carboxylate synthase 2	Zea mays	69-104
18762249-3	2008	TAK1 (TGF-beta activated kinase 1), a MAP3K, interacts with Ror2 and phosphorylates its intracellular carboxyterminal serine/thronine/proline-rich (STP) domain.	Proline	134-141	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	0-4
18762249-3	2008	TAK1 (TGF-beta activated kinase 1), a MAP3K, interacts with Ror2 and phosphorylates its intracellular carboxyterminal serine/thronine/proline-rich (STP) domain.	Proline	134-141	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	6-33
18762249-3	2008	TAK1 (TGF-beta activated kinase 1), a MAP3K, interacts with Ror2 and phosphorylates its intracellular carboxyterminal serine/thronine/proline-rich (STP) domain.	Proline	134-141	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	38-43
18762249-3	2008	TAK1 (TGF-beta activated kinase 1), a MAP3K, interacts with Ror2 and phosphorylates its intracellular carboxyterminal serine/thronine/proline-rich (STP) domain.	Proline	134-141	receptor tyrosine kinase like orphan receptor 2	Homo sapiens	60-64
16219779-0	2006	Effect of mutation of the tetratricopeptide repeat and asparatate-proline 2 domains of Sti1 on Hsp90 signaling and interaction in Saccharomyces cerevisiae.	Proline	66-73	Hsp90 cochaperone STI1	Saccharomyces cerevisiae S288C	87-91
16219779-0	2006	Effect of mutation of the tetratricopeptide repeat and asparatate-proline 2 domains of Sti1 on Hsp90 signaling and interaction in Saccharomyces cerevisiae.	Proline	66-73	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	95-100
12163590-0	2002	The metastatic suppressor Nm23-H1 interacts with EBNA3C at sequences located between the glutamine- and proline-rich domains and can cooperate in activation of transcription.	Proline	104-111	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	26-33
12163590-0	2002	The metastatic suppressor Nm23-H1 interacts with EBNA3C at sequences located between the glutamine- and proline-rich domains and can cooperate in activation of transcription.	Proline	104-111	EBNA-3C	Human gammaherpesvirus 4	49-55
12163590-5	2002	This domain lies within the region comprising amino acids 637 to 675 of EBNA3C flanked by the proline- and glutamine-rich domains.	Proline	94-101	EBNA-3C	Human gammaherpesvirus 4	72-78
34585830-2	2022	To obtain residue level information on these mobile systems we introduce two 1 H alpha -detected, proline selective, real-time homodecoupled NMR experiments and analyze the proline abundant transactivation domain of p53.	Proline	173-180	tumor protein p53	Homo sapiens	216-219
34974185-0	2022	Proline-serine-threonine-repeat region of MDC1 mediates Chk1 phosphorylation and the DNA double-strand break repair.	Proline	0-7	mediator of DNA damage checkpoint 1	Homo sapiens	42-46
34974185-0	2022	Proline-serine-threonine-repeat region of MDC1 mediates Chk1 phosphorylation and the DNA double-strand break repair.	Proline	0-7	checkpoint kinase 1	Homo sapiens	56-60
34974185-5	2022	The role of the proline-serine-threonine (PST)-repeat domain of MDC1 in the DNA damage response is unclear.	Proline	16-23	mediator of DNA damage checkpoint 1	Homo sapiens	64-68
34717971-3	2022	The latest expression-enhanced version of the spike incorporates six proline substitutions to stabilize the prefusion conformation (termed SARS-CoV-2 S HexaPro).	Proline	69-76	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	46-51
34636434-8	2022	All compounds that could inhibit the NS2B-NS3 pro complex showed potent in vitro anti-ZIKV activity with a 50% effective concentration ranging 0.024-50 microM.	Proline	46-49	KRAS proto-oncogene, GTPase	Homo sapiens	42-45
34860252-4	2022	We show that pVHL directly interacts with conserved lysine and proline residues in the MH2 domain of SMAD3, triggering degradation.	Proline	63-70	von Hippel-Lindau tumor suppressor	Homo sapiens	13-17
34774800-2	2022	Proline, Glutamic acid, and Leucine- rich Protein (PELP1) is a novel nuclear receptor co-regulator that signals across diverse signaling networks and its expression is altered in several cancers.	Proline	0-7	proline, glutamate and leucine rich protein 1	Homo sapiens	51-56
34860252-4	2022	We show that pVHL directly interacts with conserved lysine and proline residues in the MH2 domain of SMAD3, triggering degradation.	Proline	63-70	SMAD family member 3	Homo sapiens	101-106
34964176-1	2022	Human Yes-associated protein (YAP) is involved in the Hippo signaling pathway and serves as a coactivator to modulate gene expression, which contains a transactivation domain (TD) responsible for binding to the downstream TEA domain family (TEAD) of transcription factors and two WW1/2 domains that recognize the proline-rich motifs (PRMs) present in a variety of upstream protein partners through peptide-mediated interactions (PMIs).	Proline	313-320	Yes1 associated transcriptional regulator	Homo sapiens	6-28
34782742-2	2022	In addition to a methyltransferase domain, NSD2 harbors two proline-tryptophan-tryptophan-proline (PWWP) domains and five plant homeodomains (PHDs) believed to serve as chromatin reading modules.	Proline	60-67	nuclear receptor binding SET domain protein 2	Homo sapiens	43-47
34782742-2	2022	In addition to a methyltransferase domain, NSD2 harbors two proline-tryptophan-tryptophan-proline (PWWP) domains and five plant homeodomains (PHDs) believed to serve as chromatin reading modules.	Proline	60-67	HDGF like 1	Homo sapiens	99-103
34782742-2	2022	In addition to a methyltransferase domain, NSD2 harbors two proline-tryptophan-tryptophan-proline (PWWP) domains and five plant homeodomains (PHDs) believed to serve as chromatin reading modules.	Proline	90-97	nuclear receptor binding SET domain protein 2	Homo sapiens	43-47
34782742-2	2022	In addition to a methyltransferase domain, NSD2 harbors two proline-tryptophan-tryptophan-proline (PWWP) domains and five plant homeodomains (PHDs) believed to serve as chromatin reading modules.	Proline	90-97	HDGF like 1	Homo sapiens	99-103
34605046-3	2022	Freezing sensitivity of a starchless plastidic phosphoglucomutase mutant (pgm) indicated that localization of proline in the cytosol might stabilize the plasma membrane during freeze-thaw events.	Proline	110-117	phosphoglucomutase	Arabidopsis thaliana	47-65
34670007-8	2022	Transgenic plants overexpressing ALDH3I1 had higher chlorophyll content, photosynthesis rate and proline, and less accumulation of ROS and malondialdehyde compared to the WT, which contributed to stress tolerance in transgenic plants.	Proline	97-104	aldehyde dehydrogenase 3I1	Arabidopsis thaliana	33-40
34964176-1	2022	Human Yes-associated protein (YAP) is involved in the Hippo signaling pathway and serves as a coactivator to modulate gene expression, which contains a transactivation domain (TD) responsible for binding to the downstream TEA domain family (TEAD) of transcription factors and two WW1/2 domains that recognize the proline-rich motifs (PRMs) present in a variety of upstream protein partners through peptide-mediated interactions (PMIs).	Proline	313-320	Yes1 associated transcriptional regulator	Homo sapiens	30-33
34919733-0	2022	Alternative oxidase (AOX) 1a and 1d limit proline-induced oxidative stress and aid salinity recovery in Arabidopsis.	Proline	42-49	alternative oxidase 1A	Arabidopsis thaliana	0-35
34958778-11	2022	The crystal structure of the 10A1 Fab in complex with a CD99 fragment revealed that the antibody primarily recognizes a proline-rich motif (PRM) of CD99 in a manner reminiscent of SH3-PRM interactions.	Proline	120-127	FA complementation group B	Homo sapiens	34-37
34958778-11	2022	The crystal structure of the 10A1 Fab in complex with a CD99 fragment revealed that the antibody primarily recognizes a proline-rich motif (PRM) of CD99 in a manner reminiscent of SH3-PRM interactions.	Proline	120-127	CD99 molecule (Xg blood group)	Homo sapiens	56-60
34958778-11	2022	The crystal structure of the 10A1 Fab in complex with a CD99 fragment revealed that the antibody primarily recognizes a proline-rich motif (PRM) of CD99 in a manner reminiscent of SH3-PRM interactions.	Proline	120-127	CD99 molecule (Xg blood group)	Homo sapiens	148-152
34874715-3	2021	First, a virtual proline scan was performed based on folding free energy changes to obtain TGm1 variants with enhanced thermostability.	Proline	17-24	transglutaminase 1	Homo sapiens	91-95
34935148-2	2021	In this study, we reveal that a substitution of Pro for Leu at the amino acid position 409 in WRKY32 largely suppresses the short hypocotyls and expanded cotyledon phenotypes of cop1-6.	Proline	48-51	WRKY DNA-binding protein 32	Arabidopsis thaliana	94-100
34935148-2	2021	In this study, we reveal that a substitution of Pro for Leu at the amino acid position 409 in WRKY32 largely suppresses the short hypocotyls and expanded cotyledon phenotypes of cop1-6.	Proline	48-51	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	178-184
34987509-7	2021	We developed an intranasal COVID-19 subunit vaccine, based on a recombinant, six-proline-stabilized, D614G spike protein (mC-Spike) of SARS-CoV-2 linked via the LPS-binding peptide sequence mCramp (mC) to outer membrane vesicles (OMVs) from Neisseria meningitidis.	Proline	81-88	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	107-112
34919733-8	2022	During recovery from salt stress, when relatively high rates of Pro catabolism occur naturally, photosynthetic rates in aox1a.aox1d recovered slower than in WT or the single aox lines, showing that both AOX1a and AOX1d are beneficial for cellular metabolism during Pro drawdown following osmotic stress.	Proline	64-67	alternative oxidase 1A	Arabidopsis thaliana	203-208
34919733-8	2022	During recovery from salt stress, when relatively high rates of Pro catabolism occur naturally, photosynthetic rates in aox1a.aox1d recovered slower than in WT or the single aox lines, showing that both AOX1a and AOX1d are beneficial for cellular metabolism during Pro drawdown following osmotic stress.	Proline	64-67	alternative oxidase 1D	Arabidopsis thaliana	213-218
34919733-8	2022	During recovery from salt stress, when relatively high rates of Pro catabolism occur naturally, photosynthetic rates in aox1a.aox1d recovered slower than in WT or the single aox lines, showing that both AOX1a and AOX1d are beneficial for cellular metabolism during Pro drawdown following osmotic stress.	Proline	265-268	alternative oxidase 1D	Arabidopsis thaliana	213-218
34919733-9	2022	This work provides physiological evidence of a beneficial role for AOX1a but also the less studied AOX1d isoform in allowing safe catabolism of alternative respiratory substrates like Pro.	Proline	184-187	alternative oxidase 1A	Arabidopsis thaliana	67-72
34919733-9	2022	This work provides physiological evidence of a beneficial role for AOX1a but also the less studied AOX1d isoform in allowing safe catabolism of alternative respiratory substrates like Pro.	Proline	184-187	alternative oxidase 1D	Arabidopsis thaliana	99-104
34919733-3	2022	Following Pro treatment, AOX1a and AOX1d accumulate at transcript and protein levels, with AOX1d approaching the level of the typically dominant AOX1a isoform.	Proline	10-13	alternative oxidase 1A	Arabidopsis thaliana	25-30
34919733-3	2022	Following Pro treatment, AOX1a and AOX1d accumulate at transcript and protein levels, with AOX1d approaching the level of the typically dominant AOX1a isoform.	Proline	10-13	alternative oxidase 1D	Arabidopsis thaliana	35-40
34919733-3	2022	Following Pro treatment, AOX1a and AOX1d accumulate at transcript and protein levels, with AOX1d approaching the level of the typically dominant AOX1a isoform.	Proline	10-13	alternative oxidase 1D	Arabidopsis thaliana	91-96
34919733-3	2022	Following Pro treatment, AOX1a and AOX1d accumulate at transcript and protein levels, with AOX1d approaching the level of the typically dominant AOX1a isoform.	Proline	10-13	alternative oxidase 1A	Arabidopsis thaliana	145-150
34919733-6	2022	Generation of aox1a.aox1d lines showed complete loss of AOX proteins and activity upon Pro treatment, yet full respiratory induction in response to Pro remained possible via the cytochrome pathway.	Proline	87-90	alternative oxidase 1A	Arabidopsis thaliana	14-19
34919733-6	2022	Generation of aox1a.aox1d lines showed complete loss of AOX proteins and activity upon Pro treatment, yet full respiratory induction in response to Pro remained possible via the cytochrome pathway.	Proline	87-90	alternative oxidase 1D	Arabidopsis thaliana	20-25
34919733-6	2022	Generation of aox1a.aox1d lines showed complete loss of AOX proteins and activity upon Pro treatment, yet full respiratory induction in response to Pro remained possible via the cytochrome pathway.	Proline	148-151	alternative oxidase 1A	Arabidopsis thaliana	14-19
34919733-7	2022	However, aox1a.aox1d leaves displayed symptoms of elevated oxidative stress and suffered increased oxidative damage during Pro metabolism compared to the WT or the single mutants.	Proline	123-126	alternative oxidase 1A	Arabidopsis thaliana	9-14
34919733-7	2022	However, aox1a.aox1d leaves displayed symptoms of elevated oxidative stress and suffered increased oxidative damage during Pro metabolism compared to the WT or the single mutants.	Proline	123-126	alternative oxidase 1D	Arabidopsis thaliana	15-20
34943229-14	2021	The review also discusses the role of interconversion of proline/glutamate/ornithine in supporting proline to PRODH/POX-dependent functions.	Proline	99-106	proline dehydrogenase 1	Homo sapiens	110-115
34695755-3	2021	The Gid4 component of the GID ligase complex is responsible for recognizing the N-terminal proline residue of the target substrates under normal conditions.	Proline	91-98	glucose-induced degradation complex subunit VID24	Saccharomyces cerevisiae S288C	4-8
34943229-5	2021	PRODH/POX is a mitochondrial enzyme that converts proline into pyrroline-5-carboxylate (P5C).	Proline	50-57	proline dehydrogenase 1	Homo sapiens	0-5
34943229-5	2021	PRODH/POX is a mitochondrial enzyme that converts proline into pyrroline-5-carboxylate (P5C).	Proline	50-57	proline dehydrogenase 1	Homo sapiens	6-9
34943229-7	2021	However, the critical factor in driving PRODH/POX-dependent functions is proline availability.	Proline	73-80	proline dehydrogenase 1	Homo sapiens	40-45
34757726-4	2021	Previously, we showed that proline substitutions in the arginine-rich bridge helix (BH) of Streptococcus pyogenes Cas9 (SpyCas9-L64P-K65P, SpyCas92Pro) improve target DNA cleavage selectivity.	Proline	27-34	type II CRISPR RNA-guided endonuclease Cas9	Streptococcus pyogenes	114-118
34695755-7	2021	Although Gid10 shares many structural features with the Gid4 protein from yeast and humans, the current structure explains the unique structural difference for the preference of bulky hydrophobic residue at the second position of Pro/N-degron.	Proline	230-233	glucose-induced degradation complex subunit VID24	Saccharomyces cerevisiae S288C	56-60
34735113-7	2021	aegypti, in agreement with the high conservation of the proline at this position of NS5 in DENV2, 3, and 4.	Proline	56-63	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	84-87
34699869-3	2021	The peptide-based therapeutics was created via co-assembling a pentapeptide containing a 4-amino proline residue with its derivatives containing IDO-1 inhibitor NLG919.	Proline	97-104	indoleamine 2,3-dioxygenase 1	Mus musculus	145-150
34943229-14	2021	The review also discusses the role of interconversion of proline/glutamate/ornithine in supporting proline to PRODH/POX-dependent functions.	Proline	99-106	proline dehydrogenase 1	Homo sapiens	116-119
34880421-3	2021	We recently found that p53 binds via its proline-rich domain to peptidase D (PEPD) and is activated when the binding is disrupted.	Proline	41-48	tumor protein p53	Homo sapiens	23-26
34943229-7	2021	However, the critical factor in driving PRODH/POX-dependent functions is proline availability.	Proline	73-80	proline dehydrogenase 1	Homo sapiens	46-49
34943229-8	2021	The amount of this amino acid is regulated at the level of prolidase (proline releasing enzyme), collagen biosynthesis (proline utilizing process), and glutamine, glutamate, alpha-ketoglutarate, and ornithine metabolism.	Proline	70-77	peptidase D	Homo sapiens	59-68
34943229-10	2021	It seems that in estrogen receptor-positive breast cancer cells, prolidase supports proline for collagen biosynthesis, limiting its availability for PRODH/POX-dependent apoptosis.	Proline	84-91	peptidase D	Homo sapiens	65-74
34880421-3	2021	We recently found that p53 binds via its proline-rich domain to peptidase D (PEPD) and is activated when the binding is disrupted.	Proline	41-48	peptidase D	Homo sapiens	64-75
34880421-3	2021	We recently found that p53 binds via its proline-rich domain to peptidase D (PEPD) and is activated when the binding is disrupted.	Proline	41-48	peptidase D	Homo sapiens	77-81
34806099-1	2021	A series of amine bisphenol (ABP) pro-ligands featuring amino acid ester pendant arms were prepared.	Proline	34-37	amine oxidase copper containing 1	Homo sapiens	29-32
34854557-2	2022	Here we describe two families with an ultrarare ACVR1 gain-of-function pathogenic variant (codon 375, Arginine > Proline; ACVR1R375P ) responsible for a mild nonclassic fibrodysplasia ossificans progressiva (FOP) phenotype.	Proline	113-120	activin A receptor type 1	Homo sapiens	48-53
34943229-11	2021	Moreover, lack of free proline (known to upregulate the transcriptional activity of hypoxia-inducible factor 1, HIF-1) contributes to downregulation of HIF-1-dependent pro-survival activity.	Proline	23-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-117
34943229-11	2021	Moreover, lack of free proline (known to upregulate the transcriptional activity of hypoxia-inducible factor 1, HIF-1) contributes to downregulation of HIF-1-dependent pro-survival activity.	Proline	23-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-157
34943229-14	2021	The review also discusses the role of interconversion of proline/glutamate/ornithine in supporting proline to PRODH/POX-dependent functions.	Proline	57-64	proline dehydrogenase 1	Homo sapiens	110-115
34943229-14	2021	The review also discusses the role of interconversion of proline/glutamate/ornithine in supporting proline to PRODH/POX-dependent functions.	Proline	57-64	proline dehydrogenase 1	Homo sapiens	116-119
34800360-4	2021	A conserved disease-linked proline residue is responsible for RHBDL2"s recognizing the active conformation of Orai1, which is required to sharpen switch-like signaling triggered by store-operated calcium entry.	Proline	27-34	rhomboid like 2	Homo sapiens	62-68
34800360-4	2021	A conserved disease-linked proline residue is responsible for RHBDL2"s recognizing the active conformation of Orai1, which is required to sharpen switch-like signaling triggered by store-operated calcium entry.	Proline	27-34	ORAI calcium release-activated calcium modulator 1	Homo sapiens	110-115
34273023-0	2021	PYCR, a key enzyme in proline metabolism, functions in tumorigenesis.	Proline	22-29	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-4
34273023-1	2021	Pyrroline-5-carboxylate reductase (PYCR), the last enzyme in proline synthesis that converts P5C into proline, was found promoting cancer growth and inhibiting apoptosis through multiple approaches, including regulating cell cycle and redox homeostasis, and promoting growth signaling pathways.	Proline	61-68	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-33
34273023-1	2021	Pyrroline-5-carboxylate reductase (PYCR), the last enzyme in proline synthesis that converts P5C into proline, was found promoting cancer growth and inhibiting apoptosis through multiple approaches, including regulating cell cycle and redox homeostasis, and promoting growth signaling pathways.	Proline	61-68	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-39
34085157-1	2021	Proline oxidase (POX) is mitochondrial proline-degrading enzyme of dual apoptosis/survival function.	Proline	39-46	proline dehydrogenase 1	Homo sapiens	0-15
34085157-2	2021	POX expression and proline availability are considered an underlying mechanism for differential POX functions.	Proline	19-26	proline dehydrogenase 1	Homo sapiens	96-99
34273023-1	2021	Pyrroline-5-carboxylate reductase (PYCR), the last enzyme in proline synthesis that converts P5C into proline, was found promoting cancer growth and inhibiting apoptosis through multiple approaches, including regulating cell cycle and redox homeostasis, and promoting growth signaling pathways.	Proline	102-109	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-33
34085157-1	2021	Proline oxidase (POX) is mitochondrial proline-degrading enzyme of dual apoptosis/survival function.	Proline	39-46	proline dehydrogenase 1	Homo sapiens	17-20
34273023-1	2021	Pyrroline-5-carboxylate reductase (PYCR), the last enzyme in proline synthesis that converts P5C into proline, was found promoting cancer growth and inhibiting apoptosis through multiple approaches, including regulating cell cycle and redox homeostasis, and promoting growth signaling pathways.	Proline	102-109	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-39
34085157-5	2021	Inhibition of collagen biosynthesis (proline utilizing process) by 2-methoxyestradiol (2ME) contributed to induction of apoptosis in MCF-7WT cells, as detected by increase in the expression of active caspase-3, -9 and p53.	Proline	37-44	caspase 3	Homo sapiens	200-213
34085157-5	2021	Inhibition of collagen biosynthesis (proline utilizing process) by 2-methoxyestradiol (2ME) contributed to induction of apoptosis in MCF-7WT cells, as detected by increase in the expression of active caspase-3, -9 and p53.	Proline	37-44	tumor protein p53	Homo sapiens	218-221
34291342-1	2021	Delta1-Pyrroline-5-carboxylate (P5C) reductase (PYCR or P5CR) catalyzes the conversion of P5C to L-proline (Pro) with concomitant oxidation of a cofactor, NADPH or NADH.	Proline	108-111	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-30
34291342-1	2021	Delta1-Pyrroline-5-carboxylate (P5C) reductase (PYCR or P5CR) catalyzes the conversion of P5C to L-proline (Pro) with concomitant oxidation of a cofactor, NADPH or NADH.	Proline	108-111	pyrroline-5-carboxylate reductase 1	Homo sapiens	32-35
34291342-1	2021	Delta1-Pyrroline-5-carboxylate (P5C) reductase (PYCR or P5CR) catalyzes the conversion of P5C to L-proline (Pro) with concomitant oxidation of a cofactor, NADPH or NADH.	Proline	108-111	pyrroline-5-carboxylate reductase 1	Homo sapiens	48-52
34283310-2	2021	Proline dehydrogenase (PRODH) enzyme, which catalyzes the first step of proline catabolism, has diverse functional roles in regulating many pathophysiological processes, including apoptosis, autophagy, cell senescence, and cancer metastasis.	Proline	72-79	proline dehydrogenase 1	Homo sapiens	0-21
34291342-1	2021	Delta1-Pyrroline-5-carboxylate (P5C) reductase (PYCR or P5CR) catalyzes the conversion of P5C to L-proline (Pro) with concomitant oxidation of a cofactor, NADPH or NADH.	Proline	108-111	pyrroline-5-carboxylate reductase 1	Homo sapiens	56-60
34291342-1	2021	Delta1-Pyrroline-5-carboxylate (P5C) reductase (PYCR or P5CR) catalyzes the conversion of P5C to L-proline (Pro) with concomitant oxidation of a cofactor, NADPH or NADH.	Proline	108-111	pyrroline-5-carboxylate reductase 1	Homo sapiens	90-93
34283310-2	2021	Proline dehydrogenase (PRODH) enzyme, which catalyzes the first step of proline catabolism, has diverse functional roles in regulating many pathophysiological processes, including apoptosis, autophagy, cell senescence, and cancer metastasis.	Proline	72-79	proline dehydrogenase 1	Homo sapiens	23-28
34283311-0	2021	PINCH-1 promotes Delta1-pyrroline-5-carboxylate synthase expression and contributes to proline metabolic reprogramming in lung adenocarcinoma.	Proline	87-94	LIM and senescent cell antigen-like domains 1	Mus musculus	0-7
34390414-5	2021	Proline can be synthesized by aldehyde dehydrogenase family 18 member A1 (ALDH18A1) and delta1-pyrroline-5-carboxylate reductase (PYCR), up-regulating ALDH18A1 and PYCR can promote the proliferation and invasion of cancer cells.	Proline	0-7	aldehyde dehydrogenase 18 family member A1	Homo sapiens	30-72
34283311-2	2021	We recently identified a critical role of PINCH-1, a cell-extracellular matrix (ECM) adhesion protein whose expression is elevated in lung adenocarcinoma, in the promotion of proline biosynthesis, fibrosis and lung adenocarcinoma growth.	Proline	175-182	LIM and senescent cell antigen-like domains 1	Mus musculus	42-49
34390414-5	2021	Proline can be synthesized by aldehyde dehydrogenase family 18 member A1 (ALDH18A1) and delta1-pyrroline-5-carboxylate reductase (PYCR), up-regulating ALDH18A1 and PYCR can promote the proliferation and invasion of cancer cells.	Proline	0-7	aldehyde dehydrogenase 18 family member A1	Homo sapiens	74-82
34390414-5	2021	Proline can be synthesized by aldehyde dehydrogenase family 18 member A1 (ALDH18A1) and delta1-pyrroline-5-carboxylate reductase (PYCR), up-regulating ALDH18A1 and PYCR can promote the proliferation and invasion of cancer cells.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	88-128
34283311-3	2021	How PINCH-1 promotes proline biosynthesis, however, was incompletely understood.	Proline	21-28	LIM and senescent cell antigen-like domains 1	Mus musculus	4-11
34390414-5	2021	Proline can be synthesized by aldehyde dehydrogenase family 18 member A1 (ALDH18A1) and delta1-pyrroline-5-carboxylate reductase (PYCR), up-regulating ALDH18A1 and PYCR can promote the proliferation and invasion of cancer cells.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	130-134
34390414-5	2021	Proline can be synthesized by aldehyde dehydrogenase family 18 member A1 (ALDH18A1) and delta1-pyrroline-5-carboxylate reductase (PYCR), up-regulating ALDH18A1 and PYCR can promote the proliferation and invasion of cancer cells.	Proline	0-7	aldehyde dehydrogenase 18 family member A1	Homo sapiens	151-159
34283311-4	2021	In this study, we show that PINCH-1 promotes the expression of Delta1-pyrroline-5-carboxylate synthase (P5CS), a key enzyme that links glutamate metabolism to proline biosynthesis.	Proline	159-166	LIM and senescent cell antigen-like domains 1	Mus musculus	28-35
34390414-5	2021	Proline can be synthesized by aldehyde dehydrogenase family 18 member A1 (ALDH18A1) and delta1-pyrroline-5-carboxylate reductase (PYCR), up-regulating ALDH18A1 and PYCR can promote the proliferation and invasion of cancer cells.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	164-168
34390414-8	2021	The degradation of proline occurs in the mitochondria and involves an oxidation step catalyzed by proline dehydrogenase/proline oxidase (PRODH/POX).	Proline	19-26	proline dehydrogenase 1	Homo sapiens	137-142
34283311-4	2021	In this study, we show that PINCH-1 promotes the expression of Delta1-pyrroline-5-carboxylate synthase (P5CS), a key enzyme that links glutamate metabolism to proline biosynthesis.	Proline	159-166	aldehyde dehydrogenase 18 family, member A1	Mus musculus	69-102
34283311-4	2021	In this study, we show that PINCH-1 promotes the expression of Delta1-pyrroline-5-carboxylate synthase (P5CS), a key enzyme that links glutamate metabolism to proline biosynthesis.	Proline	159-166	aldehyde dehydrogenase 18 family, member A1	Mus musculus	104-108
34283311-8	2021	Re-expression of wild type PINCH-1, but not that of the PINCH-1 LIM2 deletion mutant, in PINCH-1 deficient lung adenocarcinoma cells restored P5CS expression, proline biosynthesis and cell proliferation.	Proline	159-166	LIM and senescent cell antigen-like domains 1	Mus musculus	27-34
34283311-11	2021	Our results reveal an important role of PINCH-1 in the promotion of P5CS expression, which likely contributes to proline metabolic reprogramming and consequently lung adenocarcinoma progression.	Proline	113-120	LIM and senescent cell antigen-like domains 1	Mus musculus	40-47
34283311-11	2021	Our results reveal an important role of PINCH-1 in the promotion of P5CS expression, which likely contributes to proline metabolic reprogramming and consequently lung adenocarcinoma progression.	Proline	113-120	aldehyde dehydrogenase 18 family, member A1	Mus musculus	68-72
34291342-1	2021	Delta1-Pyrroline-5-carboxylate (P5C) reductase (PYCR or P5CR) catalyzes the conversion of P5C to L-proline (Pro) with concomitant oxidation of a cofactor, NADPH or NADH.	Proline	97-106	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-30
34291342-1	2021	Delta1-Pyrroline-5-carboxylate (P5C) reductase (PYCR or P5CR) catalyzes the conversion of P5C to L-proline (Pro) with concomitant oxidation of a cofactor, NADPH or NADH.	Proline	97-106	pyrroline-5-carboxylate reductase 1	Homo sapiens	32-35
34291342-1	2021	Delta1-Pyrroline-5-carboxylate (P5C) reductase (PYCR or P5CR) catalyzes the conversion of P5C to L-proline (Pro) with concomitant oxidation of a cofactor, NADPH or NADH.	Proline	97-106	pyrroline-5-carboxylate reductase 1	Homo sapiens	48-52
34291342-1	2021	Delta1-Pyrroline-5-carboxylate (P5C) reductase (PYCR or P5CR) catalyzes the conversion of P5C to L-proline (Pro) with concomitant oxidation of a cofactor, NADPH or NADH.	Proline	97-106	pyrroline-5-carboxylate reductase 1	Homo sapiens	56-60
34291342-1	2021	Delta1-Pyrroline-5-carboxylate (P5C) reductase (PYCR or P5CR) catalyzes the conversion of P5C to L-proline (Pro) with concomitant oxidation of a cofactor, NADPH or NADH.	Proline	97-106	pyrroline-5-carboxylate reductase 1	Homo sapiens	90-93
34925382-9	2021	This allele loads peptides with a Proline residue anchor at position 2, and features a binding groove that can accommodate well the recently proposed consensus sequence for O-GlcNAcylation, P(V/A/T/S)g(S/T), essentially explaining why HLA-B*07:02 is a favoured binding allele.	Proline	34-41	major histocompatibility complex, class I, B	Homo sapiens	235-240
34582006-8	2021	RESULTS: We found that the Src homology 3 (SH3) domain of betaPix interacts with the proline-rich domain of Dynamin 2 (Dyn2), a large GTPase.	Proline	85-92	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	27-30
34582006-8	2021	RESULTS: We found that the Src homology 3 (SH3) domain of betaPix interacts with the proline-rich domain of Dynamin 2 (Dyn2), a large GTPase.	Proline	85-92	Rho guanine nucleotide exchange factor 7	Homo sapiens	58-65
34582006-8	2021	RESULTS: We found that the Src homology 3 (SH3) domain of betaPix interacts with the proline-rich domain of Dynamin 2 (Dyn2), a large GTPase.	Proline	85-92	dynamin 2	Homo sapiens	108-117
34582006-8	2021	RESULTS: We found that the Src homology 3 (SH3) domain of betaPix interacts with the proline-rich domain of Dynamin 2 (Dyn2), a large GTPase.	Proline	85-92	dynamin 2	Homo sapiens	119-123
34534579-4	2021	The yeast Fpr1 (FK506-sensitive proline rotamase) is a homologue of the mammalian prolyl isomerase FKBP12 (FK506-binding protein of 12 kDa).	Proline	32-39	peptidylprolyl isomerase FPR1	Saccharomyces cerevisiae S288C	10-14
34417665-6	2021	To further illustrate the connection of STAT3 protein structure with ropivacaine, the autodock-vina was used to examine the interaction between STAT3 and ropivacaine, and the results showed that ropivacaine could bind to STAT3"s proline site and other sites.	Proline	229-236	signal transducer and activator of transcription 3	Rattus norvegicus	40-45
34417665-6	2021	To further illustrate the connection of STAT3 protein structure with ropivacaine, the autodock-vina was used to examine the interaction between STAT3 and ropivacaine, and the results showed that ropivacaine could bind to STAT3"s proline site and other sites.	Proline	229-236	signal transducer and activator of transcription 3	Rattus norvegicus	144-149
34417665-6	2021	To further illustrate the connection of STAT3 protein structure with ropivacaine, the autodock-vina was used to examine the interaction between STAT3 and ropivacaine, and the results showed that ropivacaine could bind to STAT3"s proline site and other sites.	Proline	229-236	signal transducer and activator of transcription 3	Rattus norvegicus	221-226
34107832-1	2021	In certain cancers, such as breast, prostate and some lung and skin cancers, the gene for the enzyme catalysing the second and last step in proline synthesis, delta1-pyrroline-5-carboxylate (P5C) reductase, has been found upregulated.	Proline	140-147	pyrroline-5-carboxylate reductase 1	Homo sapiens	159-189
34107832-2	2021	This leads to a higher proline content that exacerbates the effects of the so-called proline-P5C cycle, with tumour cells effectively using this method to increase cell survival.	Proline	23-30	pyrroline-5-carboxylate reductase 1	Homo sapiens	93-96
34107832-2	2021	This leads to a higher proline content that exacerbates the effects of the so-called proline-P5C cycle, with tumour cells effectively using this method to increase cell survival.	Proline	85-92	pyrroline-5-carboxylate reductase 1	Homo sapiens	93-96
34107832-6	2021	The actual occurrence in vivo of enzyme inhibition was assessed on myelogenous erythroleukemic K562 and epithelial breast cancer MDA-MB-231 cell lines, whose growth was progressively impaired by concentrations of the dibromo derivative ranging from 10-6 to 10-4 M. Interestingly, growth inhibition was not relieved by the exogenous supply of proline, suggesting that the effect relies on the interference with the proline-P5C cycle, and not on proline starvation.	Proline	414-421	pyrroline-5-carboxylate reductase 1	Homo sapiens	422-425
34752700-3	2021	Given that proline dehydrogenase has been proposed to be a key enzyme in the oxidative metabolism of thioprolines, we characterized T4C and T2C as substrates of proline catabolic enzymes using proline utilization A (PutA), which is a bifunctional enzyme with proline dehydrogenase (PRODH) and l-glutamate-gamma-semialdehyde dehydrogenase (GSALDH) activities.	Proline	161-168	proline dehydrogenase 1	Homo sapiens	11-32
34752700-3	2021	Given that proline dehydrogenase has been proposed to be a key enzyme in the oxidative metabolism of thioprolines, we characterized T4C and T2C as substrates of proline catabolic enzymes using proline utilization A (PutA), which is a bifunctional enzyme with proline dehydrogenase (PRODH) and l-glutamate-gamma-semialdehyde dehydrogenase (GSALDH) activities.	Proline	161-168	proline dehydrogenase 1	Homo sapiens	259-280
34752700-3	2021	Given that proline dehydrogenase has been proposed to be a key enzyme in the oxidative metabolism of thioprolines, we characterized T4C and T2C as substrates of proline catabolic enzymes using proline utilization A (PutA), which is a bifunctional enzyme with proline dehydrogenase (PRODH) and l-glutamate-gamma-semialdehyde dehydrogenase (GSALDH) activities.	Proline	161-168	proline dehydrogenase 1	Homo sapiens	282-287
34752700-3	2021	Given that proline dehydrogenase has been proposed to be a key enzyme in the oxidative metabolism of thioprolines, we characterized T4C and T2C as substrates of proline catabolic enzymes using proline utilization A (PutA), which is a bifunctional enzyme with proline dehydrogenase (PRODH) and l-glutamate-gamma-semialdehyde dehydrogenase (GSALDH) activities.	Proline	161-168	aldehyde dehydrogenase 4 family member A1	Homo sapiens	293-337
34752700-3	2021	Given that proline dehydrogenase has been proposed to be a key enzyme in the oxidative metabolism of thioprolines, we characterized T4C and T2C as substrates of proline catabolic enzymes using proline utilization A (PutA), which is a bifunctional enzyme with proline dehydrogenase (PRODH) and l-glutamate-gamma-semialdehyde dehydrogenase (GSALDH) activities.	Proline	193-200	proline dehydrogenase 1	Homo sapiens	11-32
34752700-3	2021	Given that proline dehydrogenase has been proposed to be a key enzyme in the oxidative metabolism of thioprolines, we characterized T4C and T2C as substrates of proline catabolic enzymes using proline utilization A (PutA), which is a bifunctional enzyme with proline dehydrogenase (PRODH) and l-glutamate-gamma-semialdehyde dehydrogenase (GSALDH) activities.	Proline	193-200	proline dehydrogenase 1	Homo sapiens	259-280
34752700-3	2021	Given that proline dehydrogenase has been proposed to be a key enzyme in the oxidative metabolism of thioprolines, we characterized T4C and T2C as substrates of proline catabolic enzymes using proline utilization A (PutA), which is a bifunctional enzyme with proline dehydrogenase (PRODH) and l-glutamate-gamma-semialdehyde dehydrogenase (GSALDH) activities.	Proline	193-200	proline dehydrogenase 1	Homo sapiens	282-287
34752700-3	2021	Given that proline dehydrogenase has been proposed to be a key enzyme in the oxidative metabolism of thioprolines, we characterized T4C and T2C as substrates of proline catabolic enzymes using proline utilization A (PutA), which is a bifunctional enzyme with proline dehydrogenase (PRODH) and l-glutamate-gamma-semialdehyde dehydrogenase (GSALDH) activities.	Proline	193-200	aldehyde dehydrogenase 4 family member A1	Homo sapiens	293-337
34752700-4	2021	PutA is shown here to catalyze the FAD-dependent PRODH oxidation of both T4C and T2C with catalytic efficiencies significantly higher than with proline.	Proline	144-151	proline dehydrogenase 1	Homo sapiens	49-54
34288034-1	2021	AIM: Splicing factor proline and glutamine rich (SFPQ) is an RNA-DNA binding protein that is dysregulated in Alzheimer"s disease and frontotemporal dementia.	Proline	21-28	splicing factor proline and glutamine rich	Homo sapiens	49-53
34534579-4	2021	The yeast Fpr1 (FK506-sensitive proline rotamase) is a homologue of the mammalian prolyl isomerase FKBP12 (FK506-binding protein of 12 kDa).	Proline	32-39	FKBP prolyl isomerase 1A	Homo sapiens	99-105
34534579-4	2021	The yeast Fpr1 (FK506-sensitive proline rotamase) is a homologue of the mammalian prolyl isomerase FKBP12 (FK506-binding protein of 12 kDa).	Proline	32-39	FKBP prolyl isomerase 1A	Homo sapiens	107-138
34899793-9	2021	While the starch content was higher in pldalpha1-1 plants, proline content was significantly lower in pldalpha1-1 compared with wild type plants.	Proline	59-66	phospholipase D alpha 1	Arabidopsis thaliana	102-113
34814918-1	2021	Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function.	Proline	10-17	cyclin dependent kinase 5	Homo sapiens	0-4
34869367-7	2021	The AMPK-dependent upregulation of proline oxidase, an enzyme of proline degradation, is a key link for elevated ATP levels.	Proline	65-72	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	4-8
34560246-2	2021	This emerging evidence points to the importance of pro-oxidation as an important stimulus for endurance-training adaptations, including mitochondrial biogenesis, endogenous antioxidant production, insulin signalling, angiogenesis and growth factor signaling.	Proline	51-54	insulin	Homo sapiens	197-204
34783283-4	2021	Angiotensin-converting enzyme (ACE) (hypertension-responsible glycoprotein) and dipeptidyl peptidase IV (DPP-IV) (proline-specific dimeric aminopeptidase) have been widely used as molecular target sites of action of bioactive compounds possessing antihypertensive and antidiabetic effects.	Proline	114-121	dipeptidyl peptidase 4	Homo sapiens	80-103
34783283-4	2021	Angiotensin-converting enzyme (ACE) (hypertension-responsible glycoprotein) and dipeptidyl peptidase IV (DPP-IV) (proline-specific dimeric aminopeptidase) have been widely used as molecular target sites of action of bioactive compounds possessing antihypertensive and antidiabetic effects.	Proline	114-121	dipeptidyl peptidase 4	Homo sapiens	105-111
34783283-4	2021	Angiotensin-converting enzyme (ACE) (hypertension-responsible glycoprotein) and dipeptidyl peptidase IV (DPP-IV) (proline-specific dimeric aminopeptidase) have been widely used as molecular target sites of action of bioactive compounds possessing antihypertensive and antidiabetic effects.	Proline	114-121	carboxypeptidase Q	Homo sapiens	139-153
34781297-2	2021	In addition, the oxygen-dependent conversion of HIF-1alpha in nucleus pulposus cells is controlled by the protein Proline 4-hydroxylase domain (PHD) family.	Proline	114-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
34796404-0	2021	Destabilization of the Alzheimer"s amyloid-beta peptide by a proline-rich beta-sheet breaker peptide: a molecular dynamics simulation study.	Proline	61-68	amyloid beta precursor protein	Homo sapiens	35-47
34787457-7	2022	Deletion of the complement control protein domains CCP1 or CCP2 or the serine-threonine-proline (STP) region of CD46 reduced infection.	Proline	88-95	CD46 molecule	Homo sapiens	112-116
34869367-8	2021	This functional link is further established by proline supplementation concomitant with AMPK activation in matrix-deprived cells lacking ST antigen, yielding ATP and enhancing survival.	Proline	47-54	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	88-92
34869367-9	2021	Thus, our data establishes a key role for AMPK-dependent regulation of proline metabolism in mediating energy homeostasis and promoting survival of matrix-deprived cells.	Proline	71-78	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	42-46
34831286-2	2021	Recently, DEE73 was linked to genetic alterations of the RNF13 gene, which convert positions 311 or 312 in the RNF13 protein from leucine to serine or proline, respectively (L311S and L312P).	Proline	151-158	ring finger protein 13	Homo sapiens	57-62
34831286-2	2021	Recently, DEE73 was linked to genetic alterations of the RNF13 gene, which convert positions 311 or 312 in the RNF13 protein from leucine to serine or proline, respectively (L311S and L312P).	Proline	151-158	ring finger protein 13	Homo sapiens	111-116
34392079-5	2021	This value was improved to 101.7 and 51.8 mumol min-1 mg-1 in the presence of sorbitol and proline, respectively.	Proline	91-98	CD59 molecule (CD59 blood group)	Homo sapiens	48-58
34537235-2	2021	The principal step in this critical cellular process is the hydroxylation of either or both of the two conserved proline residues P402 and P564 within the oxygen-dependent degradation domain (ODD) of HIF-1alpha subunit via prolyl hydroxylases, which is necessary for binding VHL.	Proline	113-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	200-210
34537235-2	2021	The principal step in this critical cellular process is the hydroxylation of either or both of the two conserved proline residues P402 and P564 within the oxygen-dependent degradation domain (ODD) of HIF-1alpha subunit via prolyl hydroxylases, which is necessary for binding VHL.	Proline	113-120	von Hippel-Lindau tumor suppressor	Homo sapiens	275-278
34688656-3	2021	As evidenced by transmission electron microscopy and fluorescence and CD spectroscopy, the proline-rich domain (PRD) of ALIX, which encodes binding epitopes of multiple cellular partners, formed rope-like beta-sheet-rich reversible amyloid fibrils that dissolved upon Src-mediated phosphorylation and were restored on PTP1B-mediated dephosphorylation of its conserved tyrosine residues.	Proline	91-98	programmed cell death 6 interacting protein	Homo sapiens	120-124
34740102-7	2021	Augmented PHD2 activity was confirmed by increased hydroxylated-proline and enhanced binding of PHD2 to pAkt in alphaKG-treated platelets.	Proline	64-71	egl-9 family hypoxia-inducible factor 1	Mus musculus	10-14
34634302-6	2021	We also delineated four more regions of TAF8 each individually required for interacting with TAF2 in lobe C. Moreover, CRISPR/Cas9-mediated gene editing indicated that the 5TAF core-interacting TAF8 domain and the proline-rich domain of TAF8 that interacts with TAF2 are both required for mouse embryonic stem cell survival.	Proline	214-221	TATA-box binding protein associated factor 8	Mus musculus	40-44
34077620-7	2021	ZG16 crystal structures also draw attention to a non-proline cis peptide bond that can isomerize within the protein and to the mobility of glycine-rich loops in the glycan-binding site.	Proline	53-60	zymogen granule protein 16	Homo sapiens	0-4
34634302-6	2021	We also delineated four more regions of TAF8 each individually required for interacting with TAF2 in lobe C. Moreover, CRISPR/Cas9-mediated gene editing indicated that the 5TAF core-interacting TAF8 domain and the proline-rich domain of TAF8 that interacts with TAF2 are both required for mouse embryonic stem cell survival.	Proline	214-221	TATA-box binding protein associated factor 2	Mus musculus	93-97
34688656-3	2021	As evidenced by transmission electron microscopy and fluorescence and CD spectroscopy, the proline-rich domain (PRD) of ALIX, which encodes binding epitopes of multiple cellular partners, formed rope-like beta-sheet-rich reversible amyloid fibrils that dissolved upon Src-mediated phosphorylation and were restored on PTP1B-mediated dephosphorylation of its conserved tyrosine residues.	Proline	91-98	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	268-271
34634302-6	2021	We also delineated four more regions of TAF8 each individually required for interacting with TAF2 in lobe C. Moreover, CRISPR/Cas9-mediated gene editing indicated that the 5TAF core-interacting TAF8 domain and the proline-rich domain of TAF8 that interacts with TAF2 are both required for mouse embryonic stem cell survival.	Proline	214-221	TATA-box binding protein associated factor 8	Mus musculus	237-241
34634302-6	2021	We also delineated four more regions of TAF8 each individually required for interacting with TAF2 in lobe C. Moreover, CRISPR/Cas9-mediated gene editing indicated that the 5TAF core-interacting TAF8 domain and the proline-rich domain of TAF8 that interacts with TAF2 are both required for mouse embryonic stem cell survival.	Proline	214-221	TATA-box binding protein associated factor 2	Mus musculus	262-266
34688656-3	2021	As evidenced by transmission electron microscopy and fluorescence and CD spectroscopy, the proline-rich domain (PRD) of ALIX, which encodes binding epitopes of multiple cellular partners, formed rope-like beta-sheet-rich reversible amyloid fibrils that dissolved upon Src-mediated phosphorylation and were restored on PTP1B-mediated dephosphorylation of its conserved tyrosine residues.	Proline	91-98	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	318-323
34531295-4	2021	Here, we found tacrine could disrupt the proper trafficking of proline-rich membrane anchor-linked tetrameric AChE in the endoplasmic reticulum (ER).	Proline	63-70	acetylcholinesterase (Cartwright blood group)	Homo sapiens	110-114
34563985-12	2021	The TGF-beta-induced increase in proline incorporation, mRNA levels of Postn and alpha-SMA, and protein expression of alpha-SMA were decreased by Zer in cultured cardiac fibroblasts.	Proline	33-40	transforming growth factor alpha	Mus musculus	4-12
34611365-3	2021	We recently developed a prefusion-stabilized spike variant, termed HexaPro for six stabilizing proline substitutions, that can be expressed with a yield of >30 mg/L in ExpiCHO cells.	Proline	95-102	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	45-50
34746036-0	2021	Proline Isomerization as a Key Determinant for Hsp90-Toxin Interactions.	Proline	0-7	heat shock protein 90 alpha family class A member 1	Homo sapiens	47-52
34924709-7	2021	The expression of genes involved in the Pro biosynthesis pathway, P5CS and P5CR genes, in mutant lines were less than their parents, and conversely, P5CDH in mutant lines was more than their parents.	Proline	40-43	pyrroline-5-carboxylate reductase	Triticum aestivum	75-79
34769188-0	2021	P5C as an Interface of Proline Interconvertible Amino Acids and Its Role in Regulation of Cell Survival and Apoptosis.	Proline	23-30	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-3
34769188-3	2021	One of the important mediators in energy production and interconversion of carbons in the cell is Delta1-pyrroline-5-carboxylate (P5C)-the physiological intracellular intermediate of the interconversion of proline, ornithine, and glutamate.	Proline	206-213	pyrroline-5-carboxylate reductase 1	Homo sapiens	104-128
34769188-3	2021	One of the important mediators in energy production and interconversion of carbons in the cell is Delta1-pyrroline-5-carboxylate (P5C)-the physiological intracellular intermediate of the interconversion of proline, ornithine, and glutamate.	Proline	206-213	pyrroline-5-carboxylate reductase 1	Homo sapiens	130-133
34769188-8	2021	P5C is both a direct precursor of proline and a product of its degradation.	Proline	34-41	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-3
34769188-9	2021	The conversion of P5C to proline is catalyzed by P5C reductase (PYCR), while proline to P5C by proline dehydrogenase/oxidase (PRODH/POX).	Proline	25-32	pyrroline-5-carboxylate reductase 1	Homo sapiens	18-21
34769188-9	2021	The conversion of P5C to proline is catalyzed by P5C reductase (PYCR), while proline to P5C by proline dehydrogenase/oxidase (PRODH/POX).	Proline	25-32	pyrroline-5-carboxylate reductase 1	Homo sapiens	49-52
34769188-9	2021	The conversion of P5C to proline is catalyzed by P5C reductase (PYCR), while proline to P5C by proline dehydrogenase/oxidase (PRODH/POX).	Proline	25-32	pyrroline-5-carboxylate reductase 1	Homo sapiens	64-68
34769188-9	2021	The conversion of P5C to proline is catalyzed by P5C reductase (PYCR), while proline to P5C by proline dehydrogenase/oxidase (PRODH/POX).	Proline	25-32	pyrroline-5-carboxylate reductase 1	Homo sapiens	88-91
34769188-9	2021	The conversion of P5C to proline is catalyzed by P5C reductase (PYCR), while proline to P5C by proline dehydrogenase/oxidase (PRODH/POX).	Proline	25-32	proline dehydrogenase 1	Homo sapiens	126-131
34769188-9	2021	The conversion of P5C to proline is catalyzed by P5C reductase (PYCR), while proline to P5C by proline dehydrogenase/oxidase (PRODH/POX).	Proline	77-84	pyrroline-5-carboxylate reductase 1	Homo sapiens	18-21
34769188-9	2021	The conversion of P5C to proline is catalyzed by P5C reductase (PYCR), while proline to P5C by proline dehydrogenase/oxidase (PRODH/POX).	Proline	77-84	pyrroline-5-carboxylate reductase 1	Homo sapiens	88-91
34769188-9	2021	The conversion of P5C to proline is catalyzed by P5C reductase (PYCR), while proline to P5C by proline dehydrogenase/oxidase (PRODH/POX).	Proline	77-84	proline dehydrogenase 1	Homo sapiens	126-131
34769188-10	2021	P5C-proline-P5C interconversion forms a functional redox couple.	Proline	4-11	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-3
34769188-10	2021	P5C-proline-P5C interconversion forms a functional redox couple.	Proline	4-11	pyrroline-5-carboxylate reductase 1	Homo sapiens	12-15
34769188-12	2021	This review focuses on the metabolism of P5C in the cell as an interconversion mediator of proline, glutamate, and ornithine and its role in the regulation of survival and death with particular emphasis on the metabolic context.	Proline	91-98	pyrroline-5-carboxylate reductase 1	Homo sapiens	41-44
34663735-2	2021	Our previous work identified Gid4 as a recognition component (N-recognin) of the Saccharomyces cerevisiae proteolytic system termed the proline (Pro)/N-degron pathway.	Proline	136-143	glucose-induced degradation complex subunit VID24	Saccharomyces cerevisiae S288C	29-33
34663735-2	2021	Our previous work identified Gid4 as a recognition component (N-recognin) of the Saccharomyces cerevisiae proteolytic system termed the proline (Pro)/N-degron pathway.	Proline	145-148	glucose-induced degradation complex subunit VID24	Saccharomyces cerevisiae S288C	29-33
34663735-5	2021	Gid4 is also required for degradation of Nt-Xaa-Pro (Xaa is any amino acid residue) proteins such as Nt-(Ala-Pro)-Aro10 and Nt-(Ser-Pro)-Pck1, with Pro at position 2.	Proline	148-151	glucose-induced degradation complex subunit VID24	Saccharomyces cerevisiae S288C	0-4
34543572-2	2021	Starting with the screening hit 1, a combination of structure-activity relationship and protein structure-guided drug design led to the discovery of a differently oriented carbazole 9 with favorable binding to the tryptophan, proline, and phenylalanine (WPF) shelf conserved in the BET family.	Proline	226-233	delta/notch like EGF repeat containing	Homo sapiens	282-285
34768798-8	2021	alpha-TC accumulating plants produced more methylated proline- and glycine- betaines, and showed greater activity of superoxide dismutase than gamma-TC deficient plants.	Proline	54-61	centroradiali	Arabidopsis thaliana	0-8
34668514-3	2021	2-oxoglutarate- and iron-dependent oxygenase domain-containing protein 1 (Ogfod1), which hydroxylates a proline in ribosomal protein s23 is a newly-described member of this family.	Proline	104-111	2-oxoglutarate and iron-dependent oxygenase domain containing 1	Mus musculus	74-80
34682765-4	2021	PRODH/POX degrades proline yielding reactive oxygen species (ROS).	Proline	19-26	proline dehydrogenase 1	Homo sapiens	0-5
34682765-4	2021	PRODH/POX degrades proline yielding reactive oxygen species (ROS).	Proline	19-26	proline dehydrogenase 1	Homo sapiens	6-9
34682765-9	2021	The data suggest that TGZ-induced apoptosis in MDA-MB-231 cells cultured in medium without estradiol or deprived of ERbeta is mediated by PRODH/POX and the process is facilitated by proline availability for PRODH/POX by TGZ-dependent inhibition of collagen biosynthesis.	Proline	182-189	proline dehydrogenase 1	Homo sapiens	207-212
34461095-2	2021	Here, we demonstrate that the prefusion-stabilized two-proline "S2P" spike -widely employed for laboratory work and clinical studies- unfolds when stored at 4  C, physiological pH, as observed by electron microscopy (EM) and differential scanning calorimetry, but that its trimeric, native-like conformation can be reacquired by low pH treatment.	Proline	55-62	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	69-74
34682765-9	2021	The data suggest that TGZ-induced apoptosis in MDA-MB-231 cells cultured in medium without estradiol or deprived of ERbeta is mediated by PRODH/POX and the process is facilitated by proline availability for PRODH/POX by TGZ-dependent inhibition of collagen biosynthesis.	Proline	182-189	proline dehydrogenase 1	Homo sapiens	213-216
34559968-5	2021	In proline, tau is nearly proportional to eta.	Proline	3-10	microtubule associated protein tau	Homo sapiens	12-15
34615379-7	2021	PRO reduced the cytokine levels of TNF-alpha, IL-12 and IL-8 and inhibited tyrosinase.	Proline	0-3	tumor necrosis factor	Homo sapiens	35-44
34615379-7	2021	PRO reduced the cytokine levels of TNF-alpha, IL-12 and IL-8 and inhibited tyrosinase.	Proline	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
34615379-7	2021	PRO reduced the cytokine levels of TNF-alpha, IL-12 and IL-8 and inhibited tyrosinase.	Proline	0-3	tyrosinase	Homo sapiens	75-85
34508780-7	2021	While ADO appears to use extensive flexibility to handle substrates of different sizes, it also employs proline and proline pairs to maintain the core protein structure and to retain the residues critical for catalysis in place.	Proline	104-111	2-aminoethanethiol dioxygenase	Homo sapiens	6-9
34508780-7	2021	While ADO appears to use extensive flexibility to handle substrates of different sizes, it also employs proline and proline pairs to maintain the core protein structure and to retain the residues critical for catalysis in place.	Proline	116-123	2-aminoethanethiol dioxygenase	Homo sapiens	6-9
34690696-1	2021	Glycogen synthase kinase 3 (GSK3) is a proline-directed serine-threonine kinase that is associated with several neurological disorders, including Alzheimer"s disease and fragile X syndrome (FXS).	Proline	39-46	glycogen synthase kinase 3 beta	Mus musculus	0-26
34690696-1	2021	Glycogen synthase kinase 3 (GSK3) is a proline-directed serine-threonine kinase that is associated with several neurological disorders, including Alzheimer"s disease and fragile X syndrome (FXS).	Proline	39-46	glycogen synthase kinase 3 beta	Mus musculus	28-32
34175703-2	2021	Excessive exposure to cobalt or inactivation of the unique proline isomerase Pin1 contributes to age-dependent neurodegeneration.	Proline	59-66	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	77-81
34310938-0	2021	Disease-associated mutations affect TIA1 phase separation and aggregation in a proline-dependent manner.	Proline	79-86	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	36-40
34310938-4	2021	It has recently been shown that the proline-rich domain affects the LLPS process of some proteins (such as UBQLN2 and Tau).	Proline	36-43	ubiquilin 2	Homo sapiens	107-113
34310938-4	2021	It has recently been shown that the proline-rich domain affects the LLPS process of some proteins (such as UBQLN2 and Tau).	Proline	36-43	microtubule associated protein tau	Homo sapiens	118-121
34310938-6	2021	The LCD of TIA1 contains 11 proline residues, and several proline-related mutations have been shown to cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).	Proline	28-35	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	11-15
34310938-6	2021	The LCD of TIA1 contains 11 proline residues, and several proline-related mutations have been shown to cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).	Proline	58-65	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	11-15
34310938-8	2021	Additionally, disease-associated proline-to-leucine (P-L) mutations, which altered droplet morphology, facilitated the liquid-to-solid phase transition of TIA1 into solid-like amyloid fibrils.	Proline	33-40	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	155-159
34310938-10	2021	Prolines are the key residues for regulating the LLPS of TIA1.	Proline	0-8	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	57-61
34473990-9	2021	We found that released hTau was phosphorylated in its proline-rich and C-terminal domains using phosphorylation site-specific tau antibodies (e.g., AT8).	Proline	54-61	microtubule associated protein tau	Homo sapiens	23-27
34576795-5	2021	Here, we isolated a yeast mutant with high levels of intracellular proline and found a missense mutation (Gln79His) on the PRO1 gene encoding the gamma-glutamyl kinase Pro1, a limiting enzyme in proline biosynthesis.	Proline	67-74	glutamate 5-kinase	Saccharomyces cerevisiae S288C	168-172
34405853-5	2021	Changing leucine to alanine, proline, or glutamate increased the maximum rate of ATP turnover (kcat) of p47-regulated ATPase activities for these mutants, but not for WT.	Proline	29-36	pleckstrin	Homo sapiens	104-107
34405853-6	2021	p37 and p47 increased the kcat of the proline substituted linker, suggesting that they induced linker conformations facilitating ATP hydrolysis.	Proline	38-45	nucleoporin 37	Homo sapiens	0-3
34405853-6	2021	p37 and p47 increased the kcat of the proline substituted linker, suggesting that they induced linker conformations facilitating ATP hydrolysis.	Proline	38-45	pleckstrin	Homo sapiens	8-11
34528073-4	2022	The with-no-lysine kinase (WNK)-STE20/SPS1-related proline/alanine-rich (SPAK) kinase signaling pathway inhibits neuronal KCC2 via KCC2-T1007 phosphorylation.	Proline	51-58	serine/threonine kinase 24	Homo sapiens	32-37
34528073-4	2022	The with-no-lysine kinase (WNK)-STE20/SPS1-related proline/alanine-rich (SPAK) kinase signaling pathway inhibits neuronal KCC2 via KCC2-T1007 phosphorylation.	Proline	51-58	selenophosphate synthetase 1	Homo sapiens	38-42
34528073-4	2022	The with-no-lysine kinase (WNK)-STE20/SPS1-related proline/alanine-rich (SPAK) kinase signaling pathway inhibits neuronal KCC2 via KCC2-T1007 phosphorylation.	Proline	51-58	serine/threonine kinase 39	Homo sapiens	73-77
34528073-4	2022	The with-no-lysine kinase (WNK)-STE20/SPS1-related proline/alanine-rich (SPAK) kinase signaling pathway inhibits neuronal KCC2 via KCC2-T1007 phosphorylation.	Proline	51-58	solute carrier family 12 member 5	Homo sapiens	122-126
34575782-0	2021	Proline-Specific Fungal Peptidases: Genomic Analysis and Identification of Secreted DPP4 in Alkaliphilic and Alkalitolerant Fungi.	Proline	0-7	dipeptidyl peptidase 4	Homo sapiens	84-88
34471235-7	2021	Mass spectrometry analysis identified P4H prolyl hydroxylase in the YAP1 complex and YAP1 was hydroxylated at multiple proline residues.	Proline	119-126	Yes1 associated transcriptional regulator	Homo sapiens	85-89
34471235-8	2021	Proline-to-alanine mutations of YAP1 isoform 3 identified proline 174 as a critical residue, and its hydroxylation suppressed cell migration, invasion, and metastasis.	Proline	0-7	Yes1 associated transcriptional regulator	Homo sapiens	32-36
34471235-8	2021	Proline-to-alanine mutations of YAP1 isoform 3 identified proline 174 as a critical residue, and its hydroxylation suppressed cell migration, invasion, and metastasis.	Proline	58-65	Yes1 associated transcriptional regulator	Homo sapiens	32-36
34565308-0	2021	Administration of cyclic glycine-proline during infancy improves adult spatial memory, astrocyte plasticity, vascularization and GluR-1 expression in rats.	Proline	33-40	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	129-135
34260076-1	2021	The Ebola virus VP30 protein interacts with the viral nucleoprotein and with host protein RBBP6 via PPxPxY motifs that adopt non-canonical orientations, as compared to other proline-rich motifs.	Proline	174-181	RB binding protein 6, ubiquitin ligase	Homo sapiens	90-95
34447991-1	2021	Translation of mRNAs that encode peptide sequences with consecutive prolines (polyproline) requires the conserved and essential elongation factor eIF5A to facilitate the formation of peptide bonds.	Proline	68-76	eukaryotic translation initiation factor 5A	Homo sapiens	146-151
34447991-2	2021	It has been shown that upon eIF5A depletion, yeast ribosomes stall in polyproline motifs, but also in tripeptide sequences that combine proline with glycine and charged amino acids.	Proline	136-143	eukaryotic translation initiation factor 5A	Homo sapiens	28-33
34499020-5	2021	Pin1 is an attractive target for cancer therapy due to its over-expression and/or activation in various types of cancer and the disorder of Proline directed phosphorylation.	Proline	140-147	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
34576795-5	2021	Here, we isolated a yeast mutant with high levels of intracellular proline and found a missense mutation (Gln79His) on the PRO1 gene encoding the gamma-glutamyl kinase Pro1, a limiting enzyme in proline biosynthesis.	Proline	195-202	glutamate 5-kinase	Saccharomyces cerevisiae S288C	123-127
34576795-5	2021	Here, we isolated a yeast mutant with high levels of intracellular proline and found a missense mutation (Gln79His) on the PRO1 gene encoding the gamma-glutamyl kinase Pro1, a limiting enzyme in proline biosynthesis.	Proline	195-202	glutamate 5-kinase	Saccharomyces cerevisiae S288C	168-172
34576795-6	2021	The amino acid change of Gln79 to His in Pro1 resulted in desensitization to the proline-mediated feedback inhibition of GK activity, leading to the accumulation of proline in cells.	Proline	81-88	glutamate 5-kinase	Saccharomyces cerevisiae S288C	41-45
34576795-6	2021	The amino acid change of Gln79 to His in Pro1 resulted in desensitization to the proline-mediated feedback inhibition of GK activity, leading to the accumulation of proline in cells.	Proline	165-172	glutamate 5-kinase	Saccharomyces cerevisiae S288C	41-45
34576795-7	2021	Biochemical and in silico analyses showed that the amino acid residue at position 79 is involved in the stabilization of the proline binding pocket in Pro1 via a hydrogen-bonding network, which plays an important role in feedback inhibition.	Proline	125-132	glutamate 5-kinase	Saccharomyces cerevisiae S288C	151-155
34489423-5	2021	Isothermal titration calorimetry and size-exclusion chromatography revealed that proline:arginine (PR) poly-dipeptides tightly bind karyopherin-beta2 (Kapbeta2) at 1:1 ratio.	Proline	81-88	transportin 1	Homo sapiens	132-149
34578359-4	2021	The viral ssDNA-binding protein (DBP) is a major component of RCs that contains intrinsically disordered and low complexity proline-rich regions, features shared with proteins that drive phase transitions.	Proline	124-131	D-box binding PAR bZIP transcription factor	Homo sapiens	33-36
34424695-0	2021	Proline Isomerization Regulates the Phase Behavior of Elastin-Like Polypeptides in Water.	Proline	0-7	elastin	Homo sapiens	54-61
34218442-0	2021	How signaling pathways link extracellular mechano-environment to proline biosynthesis: A hypothesis: PINCH-1 and kindlin-2 sense mechanical signals from extracellular matrix and link them to proline biosynthesis.	Proline	65-72	LIM zinc finger domain containing 1	Homo sapiens	101-108
34218442-0	2021	How signaling pathways link extracellular mechano-environment to proline biosynthesis: A hypothesis: PINCH-1 and kindlin-2 sense mechanical signals from extracellular matrix and link them to proline biosynthesis.	Proline	65-72	FERM domain containing kindlin 2	Homo sapiens	113-122
34218442-0	2021	How signaling pathways link extracellular mechano-environment to proline biosynthesis: A hypothesis: PINCH-1 and kindlin-2 sense mechanical signals from extracellular matrix and link them to proline biosynthesis.	Proline	191-198	LIM zinc finger domain containing 1	Homo sapiens	101-108
34218442-0	2021	How signaling pathways link extracellular mechano-environment to proline biosynthesis: A hypothesis: PINCH-1 and kindlin-2 sense mechanical signals from extracellular matrix and link them to proline biosynthesis.	Proline	191-198	FERM domain containing kindlin 2	Homo sapiens	113-122
34218442-1	2021	We propose a signaling pathway in which cell-extracellular matrix (ECM) adhesion components PINCH-1 and kindlin-2 sense mechanical signals from ECM and link them to proline biosynthesis, a vital metabolic pathway for macromolecule synthesis, redox balance, and ECM remodeling.	Proline	165-172	LIM zinc finger domain containing 1	Homo sapiens	92-99
34218442-1	2021	We propose a signaling pathway in which cell-extracellular matrix (ECM) adhesion components PINCH-1 and kindlin-2 sense mechanical signals from ECM and link them to proline biosynthesis, a vital metabolic pathway for macromolecule synthesis, redox balance, and ECM remodeling.	Proline	165-172	FERM domain containing kindlin 2	Homo sapiens	104-113
34218442-4	2021	Additionally, PINCH-1 promotes P5C synthase (P5CS) expression and P5C synthesis, which, together with increased PYCR1 level, support augmented proline biosynthesis.	Proline	143-150	LIM zinc finger domain containing 1	Homo sapiens	14-21
34466116-8	2021	The second novel variant (c.1049delT) (p. Ser334Pro) was also observed in exon 2 of the BMP15 gene, which substituted serine into proline at 334th amino acid of the BMP15 protein.	Proline	130-137	bone morphogenetic protein 15	Homo sapiens	88-93
34386081-7	2021	A higher frequency of CYP1A1*2C heterozygotes and TP53 rare homozygotes, which include the proline (Pro)/Pro genotype, was observed among children with ALL and control subjects, whereas no significant differences were observed for the CXCL12 SNP.	Proline	91-98	tumor protein p53	Homo sapiens	50-54
34386081-7	2021	A higher frequency of CYP1A1*2C heterozygotes and TP53 rare homozygotes, which include the proline (Pro)/Pro genotype, was observed among children with ALL and control subjects, whereas no significant differences were observed for the CXCL12 SNP.	Proline	100-103	tumor protein p53	Homo sapiens	50-54
34388391-2	2021	Unique proline isomerase Pin1 regulates multiple cancer pathways, but its role in the TME and cancer immunotherapy is unknown.	Proline	7-14	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	25-29
34076875-7	2021	Bioinformatics analysis suggested the variant disease-causing; the Pro residue at 668 in the MYBPC3 protein was highly conserved.	Proline	67-70	myosin binding protein C3	Homo sapiens	93-99
34466116-8	2021	The second novel variant (c.1049delT) (p. Ser334Pro) was also observed in exon 2 of the BMP15 gene, which substituted serine into proline at 334th amino acid of the BMP15 protein.	Proline	130-137	bone morphogenetic protein 15	Homo sapiens	165-170
34532344-1	2021	Prolidase (peptidase D), encoded by the PEPD gene, is a ubiquitously expressed cytosolic metalloproteinase, the only enzyme capable of cleaving imidodipeptides containing C-terminal proline or hydroxyproline.	Proline	182-189	peptidase D	Homo sapiens	0-9
34532344-1	2021	Prolidase (peptidase D), encoded by the PEPD gene, is a ubiquitously expressed cytosolic metalloproteinase, the only enzyme capable of cleaving imidodipeptides containing C-terminal proline or hydroxyproline.	Proline	182-189	peptidase D	Homo sapiens	40-44
34462553-5	2022	Activated p38 MAPK could directly phosphorylate Bmf at multiple sites including a non-proline-directed site threonine 72 (T72).	Proline	86-93	mitogen-activated protein kinase 14	Mus musculus	10-18
34433667-5	2021	We found that two of them, FAM84B (also known as LRAT domain containing 2 or LRATD2) and PRRC1, contain proline-rich domains and regulate anterograde trafficking.	Proline	104-111	LRAT domain containing 2	Homo sapiens	27-33
34433667-5	2021	We found that two of them, FAM84B (also known as LRAT domain containing 2 or LRATD2) and PRRC1, contain proline-rich domains and regulate anterograde trafficking.	Proline	104-111	lecithin retinol acyltransferase	Homo sapiens	49-53
34433667-5	2021	We found that two of them, FAM84B (also known as LRAT domain containing 2 or LRATD2) and PRRC1, contain proline-rich domains and regulate anterograde trafficking.	Proline	104-111	proline rich coiled-coil 1	Homo sapiens	89-94
34462553-5	2022	Activated p38 MAPK could directly phosphorylate Bmf at multiple sites including a non-proline-directed site threonine 72 (T72).	Proline	86-93	BCL2 modifying factor	Mus musculus	48-51
34577574-11	2021	In MCF-7 breast cancer cells, Cx affected proline metabolism through upregulation of proline biosynthesis, PRODH/POX and PYCRs expressions, PEPD activity, and downregulation of collagen biosynthesis.	Proline	42-49	proline dehydrogenase 1	Homo sapiens	107-112
34174476-6	2021	In addition, the presence of a penultimate Pro in CG42782 and Met75C will help prevent degradation by carboxypeptidases.	Proline	43-46	uncharacterized protein	Drosophila melanogaster	50-57
34577574-11	2021	In MCF-7 breast cancer cells, Cx affected proline metabolism through upregulation of proline biosynthesis, PRODH/POX and PYCRs expressions, PEPD activity, and downregulation of collagen biosynthesis.	Proline	42-49	proline dehydrogenase 1	Homo sapiens	113-116
34577574-11	2021	In MCF-7 breast cancer cells, Cx affected proline metabolism through upregulation of proline biosynthesis, PRODH/POX and PYCRs expressions, PEPD activity, and downregulation of collagen biosynthesis.	Proline	42-49	peptidase D	Homo sapiens	140-144
34130180-9	2021	Among the many ABA-responsive genes affected by the defects of Thau1/2/3/4, reduced expression of P5CS1 with decreased accumulation phenotype of prolines indicates that compromised proline synthesis may be associated with the stress phenotypes of thau1/2/3/4.	Proline	181-188	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	98-103
34445734-4	2021	The huntingtin models consist of a wild-type structure, one mutant with 45 glutamine residues and the second mutant with nine additional key-point mutations from glutamine residues into proline residues (9P(EM) model).	Proline	186-193	huntingtin	Homo sapiens	4-14
34446744-11	2021	These studies demonstrate that the NOTCH3 protein in CADASIL is cleaved in multiple locations at labile Asp-Pro peptide bonds.	Proline	108-111	notch receptor 3	Homo sapiens	35-41
34292288-1	2021	Enantiopure alpha-Tfm-proline and alpha-Tfm-pipecolic acid were synthesized starting from commercially available diesters and ethyl trifluoroacetate.	Proline	22-29	androgen receptor	Homo sapiens	18-21
34139310-8	2021	Thus, CP-induced H2O2 and ABA cascade signal up-regulated the regulatory genes (ICE1 and CBF1) of cold acclimation, which increased the osmotic adjustment substances (proline and soluble sugar) accumulation and antioxidant enzymes (SOD, APX and CAT) activities.	Proline	167-174	C-repeat-binding factor-1	Solanum lycopersicum	89-93
34175438-1	2021	Proline rich Akt substrate (PRAS40) is a component of mammalian target of rapamycin complex 1 (mTORC1) and activated mTORC1 plays important roles for cellular survival in response to oxidative stress.	Proline	0-7	AKT1 substrate 1	Homo sapiens	28-34
34175438-1	2021	Proline rich Akt substrate (PRAS40) is a component of mammalian target of rapamycin complex 1 (mTORC1) and activated mTORC1 plays important roles for cellular survival in response to oxidative stress.	Proline	0-7	CREB regulated transcription coactivator 1	Mus musculus	95-101
34175438-1	2021	Proline rich Akt substrate (PRAS40) is a component of mammalian target of rapamycin complex 1 (mTORC1) and activated mTORC1 plays important roles for cellular survival in response to oxidative stress.	Proline	0-7	CREB regulated transcription coactivator 1	Mus musculus	117-123
34133901-6	2021	A direct interaction between NNV coat protein and PABP was demonstrated, and this binding requires the NNV coat protein N-terminal shell domain and PABP proline-rich linker region.	Proline	153-160	golgi phosphoprotein 3	Homo sapiens	33-45
34457359-5	2021	The novel c.1066C>T variant in the MFSD8 gene probably resulted in substitution of serine for proline at the 356th residue and was predicted to be "uncertain significance" through in silico analyses.	Proline	94-101	major facilitator superfamily domain containing 8	Homo sapiens	35-40
34404863-2	2021	Splicing factor proline/glutamine-rich (SFPQ) is a multifunctional nuclear RNA-binding protein (RBP) implicated in the regulation of gene expression pathways and intracellular trafficking.	Proline	16-23	splicing factor proline and glutamine rich	Homo sapiens	40-44
34404863-2	2021	Splicing factor proline/glutamine-rich (SFPQ) is a multifunctional nuclear RNA-binding protein (RBP) implicated in the regulation of gene expression pathways and intracellular trafficking.	Proline	16-23	SURP and G-patch domain containing 1	Homo sapiens	96-99
34452239-1	2021	The peptide hormone Angiotensin (1-7), Ang (1-7) or (Asp-Arg-Val-Tyr-Ile-His-Pro), is an essential component of the renin-angiotensin system (RAS) peripherally and is an agonist of the Mas receptor centrally.	Proline	77-80	angiopoietin 1	Homo sapiens	39-47
34279937-3	2021	In the current project, we investigate using single-molecule force spectroscopy (SMFS) the impact of a bacterial PPIase, SlyD, on the cis-trans isomerization of the proline 2225 (P2225) in an isolated 20th domain of a cytoskeletal mechanosensing protein filamin-A (FlnA20).	Proline	165-172	filamin A	Homo sapiens	254-263
34106747-11	2021	Importance The p12 protein of MLV and the p6 protein of HIV-1 are both supplementary Gag cleavage products that carry proline-rich motifs which facilitate virus budding.	Proline	118-125	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	15-18
34106747-11	2021	Importance The p12 protein of MLV and the p6 protein of HIV-1 are both supplementary Gag cleavage products that carry proline-rich motifs which facilitate virus budding.	Proline	118-125	Pr55(Gag)	Human immunodeficiency virus 1	85-88
34133901-6	2021	A direct interaction between NNV coat protein and PABP was demonstrated, and this binding requires the NNV coat protein N-terminal shell domain and PABP proline-rich linker region.	Proline	153-160	poly(A) binding protein cytoplasmic 1	Homo sapiens	50-54
34133901-6	2021	A direct interaction between NNV coat protein and PABP was demonstrated, and this binding requires the NNV coat protein N-terminal shell domain and PABP proline-rich linker region.	Proline	153-160	poly(A) binding protein cytoplasmic 1	Homo sapiens	148-152
34393505-5	2021	Results: The distribution of TP53 Pro72Arg differed in T2DM patients from the controls, with a moderately increased proportion of TP53 Arg72 variant carriers (Pro/Arg and Arg/Arg genotypes) (88.3% vs 81.2%, p=0.022; OR=1.089, 95% CI=1.018-1.164).	Proline	159-162	tumor protein p53	Homo sapiens	29-33
34393505-5	2021	Results: The distribution of TP53 Pro72Arg differed in T2DM patients from the controls, with a moderately increased proportion of TP53 Arg72 variant carriers (Pro/Arg and Arg/Arg genotypes) (88.3% vs 81.2%, p=0.022; OR=1.089, 95% CI=1.018-1.164).	Proline	159-162	tumor protein p53	Homo sapiens	130-134
34354228-0	2021	The structure of an archaeal oligosaccharyltransferase provides insight into the strict exclusion of proline from the N-glycosylation sequon.	Proline	101-108	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	29-54
34396115-5	2021	We first demonstrate reduced nuclear-to-cytoplasmic ratios of transactive response DNA-binding protein 43 (TDP-43), fused in sarcoma/translocated in liposarcoma (FUS) and splicing factor proline and glutamine rich (SFPQ) in VCP mutant motor neurons.	Proline	187-194	valosin containing protein	Homo sapiens	224-227
34354228-1	2021	Oligosaccharyltransferase (OST) catalyzes oligosaccharide transfer to the Asn residue in the N-glycosylation sequon, Asn-X-Ser/Thr, where Pro is strictly excluded at position X.	Proline	138-141	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	0-25
34354228-1	2021	Oligosaccharyltransferase (OST) catalyzes oligosaccharide transfer to the Asn residue in the N-glycosylation sequon, Asn-X-Ser/Thr, where Pro is strictly excluded at position X.	Proline	138-141	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	27-30
34273561-6	2021	Mechanistically, SLM2 mediates intron retention, prevents exon exclusion, and thereby mediates alternative splicing of the mRNA regions encoding the variable proline-, glutamate-, valine-, and lysine-rich (PEVK) domain and another part of the I-band region of titin.	Proline	158-165	KH RNA binding domain containing, signal transduction associated 3	Homo sapiens	17-21
34442729-3	2021	Here, we discovered that proline oxidation, catalyzed by the proline oxidase Put1, a mitochondrial flavin-dependent enzyme converting proline into  1-pyrroline-5-carboxylate, controls the chronological lifespan of the yeast Saccharomyces cerevisiae.	Proline	25-32	proline dehydrogenase	Saccharomyces cerevisiae S288C	77-81
34442729-3	2021	Here, we discovered that proline oxidation, catalyzed by the proline oxidase Put1, a mitochondrial flavin-dependent enzyme converting proline into  1-pyrroline-5-carboxylate, controls the chronological lifespan of the yeast Saccharomyces cerevisiae.	Proline	134-141	proline dehydrogenase	Saccharomyces cerevisiae S288C	77-81
34442729-6	2021	We next found that induction of the transcriptional factor Put3-dependent PUT1 and degradation of proline occur during the aging of yeast cells.	Proline	98-105	Put3p	Saccharomyces cerevisiae S288C	59-63
34442729-8	2021	More importantly, the oxidation of proline by Put1 helped maintain the mitochondrial membrane potential and ATP production through the aging period.	Proline	35-42	proline dehydrogenase	Saccharomyces cerevisiae S288C	46-50
34326443-0	2021	Publisher Correction: Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer.	Proline	45-52	WASP family member 3	Homo sapiens	68-73
34360869-4	2021	The evolutionarily-related protein p47phox and Tks4 share many similarities in their N-terminal region: a phosphoinositide-binding PX domain is followed by two SH3 domains (so called "tandem SH3") and a proline-rich region (PRR).	Proline	203-210	neutrophil cytosolic factor 1	Homo sapiens	35-42
34360869-4	2021	The evolutionarily-related protein p47phox and Tks4 share many similarities in their N-terminal region: a phosphoinositide-binding PX domain is followed by two SH3 domains (so called "tandem SH3") and a proline-rich region (PRR).	Proline	203-210	SH3 and PX domains 2B	Homo sapiens	47-51
34360869-4	2021	The evolutionarily-related protein p47phox and Tks4 share many similarities in their N-terminal region: a phosphoinositide-binding PX domain is followed by two SH3 domains (so called "tandem SH3") and a proline-rich region (PRR).	Proline	203-210	nuclear receptor subfamily 1 group I member 2	Homo sapiens	224-227
34386349-6	2021	The cells with re-engineered proline and lipid metabolism showed consistent growth and P5CS, SCD1 and SREBF1 expression across 100 cell generations.	Proline	29-36	sterol regulatory element-binding protein 1	Cricetulus griseus	102-108
34360680-6	2021	Moreover, proline level and expression of the proline biosynthesis gene P5CS1 was significantly reduced in osm34 osml.	Proline	10-17	osmotin 34	Arabidopsis thaliana	107-112
34360680-6	2021	Moreover, proline level and expression of the proline biosynthesis gene P5CS1 was significantly reduced in osm34 osml.	Proline	46-53	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	72-77
34360680-6	2021	Moreover, proline level and expression of the proline biosynthesis gene P5CS1 was significantly reduced in osm34 osml.	Proline	46-53	osmotin 34	Arabidopsis thaliana	107-112
34232285-2	2021	It interacts via its flanking nSH3 and cSH3 domains with the proline-rich domain (PRD) of the RAS activator SOS1 and via its central SH2 domain with phosphorylated tyrosine residues of receptor tyrosine kinases (RTKs; e.g., HER2).	Proline	61-68	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	108-112
34381436-7	2021	Hoxa1 mutation decreased the expression of bacterial genes involved in ABC transporters, purine metabolism, and aminoacyl-tRNA biosynthesis and increased the expression of bacterial genes involved in two-component system, starch and sucrose metabolism, and arginine and proline metabolism.	Proline	270-277	homeobox A1	Sus scrofa	0-5
34281196-11	2021	A reduction of 5-oxoproline and ornithine metabolites that are involved in proline synthesis in mitochondria and affect abiotic stresses was also observed in the mfdx1-1 mutant.	Proline	75-82	mitochondrial ferredoxin 1	Arabidopsis thaliana	162-167
34299050-6	2021	Principal component analysis of the cancer cells revealed that all these changes were in the first principal component (PC1) axis, where the responsible metabolites were involved in the metabolism of the arginine-proline, pyrimidine, and pentose phosphate pathways.	Proline	213-220	proprotein convertase subtilisin/kexin type 1	Homo sapiens	120-123
34245030-11	2022	Inoculated plants increased their root colonization ability and biomass; however, PS2 showed higher survival (95%), relative water content (59%), chlorophyll (30%), glycine betaine (38%), proline (23%), and reduced MDA (43%) in shoots than irrigated control under induced water deprivation.	Proline	188-195	inorganic pyrophosphatase 1	Arabidopsis thaliana	82-85
34121399-5	2021	Enantiomeric excesses in the range of 49-71 and 59-68% are predicted for Me2bdc-Pro and Me2bpdc-Pro catalysts with the electron-withdrawing SO3H and NMe3+ installed respectively, values much higher than those of the corresponding unmodified catalysts.	Proline	96-99	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	149-153
34276717-10	2021	It appears that the enhanced NR activities and transcript levels of NIA1 and NIA2 in pap1-D/fls1ko and fls1ko plants led to an increase in the synthesis of proteins and proline, which increases osmolytes against salt stress.	Proline	169-176	nitrate reductase 1	Arabidopsis thaliana	68-72
34276717-10	2021	It appears that the enhanced NR activities and transcript levels of NIA1 and NIA2 in pap1-D/fls1ko and fls1ko plants led to an increase in the synthesis of proteins and proline, which increases osmolytes against salt stress.	Proline	169-176	nitrate reductase 2	Arabidopsis thaliana	77-81
34276717-10	2021	It appears that the enhanced NR activities and transcript levels of NIA1 and NIA2 in pap1-D/fls1ko and fls1ko plants led to an increase in the synthesis of proteins and proline, which increases osmolytes against salt stress.	Proline	169-176	phosphatidic acid phosphatase 1	Arabidopsis thaliana	85-89
34247373-6	2021	NGS revealed that both children have carried pathogenic variants of the ANKRD11 gene (c.1903_1907del and c.4911delT), which resulted in shifting of amino acid sequences starting from the Lysine and Proline at positions 635 and 1638, respectively.	Proline	198-205	ankyrin repeat domain containing 11	Homo sapiens	72-79
34277596-4	2021	This higher chondrogenic potential of MRL MSCs was associated with a higher expression level of pyrroline-5-carboxylate reductase 1 (PYCR1), an enzyme that catalyzes the biosynthesis of proline, in MRL MSCs compared with BL6 MSCs.	Proline	186-193	pyrroline-5-carboxylate reductase 1	Mus musculus	96-131
34277596-4	2021	This higher chondrogenic potential of MRL MSCs was associated with a higher expression level of pyrroline-5-carboxylate reductase 1 (PYCR1), an enzyme that catalyzes the biosynthesis of proline, in MRL MSCs compared with BL6 MSCs.	Proline	186-193	pyrroline-5-carboxylate reductase 1	Mus musculus	133-138
34088267-3	2021	Here, we generated a transgenic rat strain, named the P347L rat, in which proline at position 347 in the rhodopsin protein was replaced with leucine.	Proline	74-81	rhodopsin	Rattus norvegicus	105-114
34157285-5	2021	We identified a highly specific recognition surface in the hydrophobic core of the CD86 TM domain that is required for recognition by MARCH1 and prominently features a proline at position 254.	Proline	168-175	CD86 molecule	Homo sapiens	83-87
34137596-4	2021	Here we show that binding of Fyn SH3, a small intracellular proline-binding domain, to the first polyproline tract of httex1Q35 inhibits fibril formation by both NMR and a thioflavin T fluorescence assay.	Proline	60-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
34205682-0	2021	The Unusual Role of Pro in Cu(II) Binding by His2-Cyclopentapeptide.	Proline	20-23	histatin 3	Homo sapiens	45-49
34205682-1	2021	In this paper, we present findings from studying the interaction of copper(II) ions with the His2-cyclopentapeptide and the role of proline used for the purpose of potentiometric titration and UV-Vis, CD and EPR spectroscopic measurements.	Proline	132-139	histatin 3	Homo sapiens	93-97
34204776-2	2021	The amino acid substitution of Arg for Pro residue in the 90th position (R90P) in gamma-tropomyosin (Tpm3.12) is associated with congenital fiber type disproportion and muscle weakness.	Proline	39-42	tropomyosin 3	Homo sapiens	101-105
34101060-1	2021	Paroxysmal kinesigenic dyskinesia is an episodic movement disorder caused by dominant mutations in the proline-rich transmembrane protein PRRT2, with onset in childhood and typically with improvement or resolution by middle age.	Proline	103-110	proline-rich transmembrane protein 2	Mus musculus	138-143
34176512-16	2021	Inverse association of dairy intakes with the odds of AMH fast decline rate was indirectly mediated by lower phosphate, proline, and BCAAs.	Proline	120-127	anti-Mullerian hormone	Homo sapiens	54-57
34112911-7	2021	Genes encoding proline rich 9 (PRR9) and late cornified envelope like proline rich 1 (LELP1) have degenerated in subgroups of cetaceans.	Proline	70-77	late cornified envelope like proline rich 1	Homo sapiens	86-91
34099711-4	2021	We demonstrate that proline/arginine repeat polymers inhibit the folding catalyst activity of PPIA, an abundant molecular chaperone and prolyl isomerase in the brain that is altered in amyotrophic lateral sclerosis.	Proline	20-27	peptidylprolyl isomerase A	Homo sapiens	94-98
34099711-5	2021	NMR spectroscopy reveals that proline/arginine repeat polymers bind to the active site of PPIA.	Proline	30-37	peptidylprolyl isomerase A	Homo sapiens	90-94
34099711-7	2021	The combined data establish a toxic mechanism that is specific for proline/arginine dipeptide repeat polymers and leads to derailed protein homeostasis in C9orf72-associated neurodegenerative diseases.	Proline	67-74	C9orf72-SMCR8 complex subunit	Homo sapiens	155-162
34059939-7	2021	The supplementation of culture medium with 6 % (v/v) DMSO and 1 M proline onto a gradient glycerol/constant methanol feeding promoted increased biosynthesis levels of STEAP1 and minimized aggregation events.	Proline	66-73	STEAP family member 1	Homo sapiens	167-173
34258421-7	2021	Oral administration of Put and Pro decreased (P < 0.05) serum ALP levels and increased (P < 0.05) intestinal SLC36A1 and SLC1A1 mRNA abundances and mTOR pathway phosphorylation levels in post-weaning pigs.	Proline	31-34	ALPA	Sus scrofa	62-65
34258421-7	2021	Oral administration of Put and Pro decreased (P < 0.05) serum ALP levels and increased (P < 0.05) intestinal SLC36A1 and SLC1A1 mRNA abundances and mTOR pathway phosphorylation levels in post-weaning pigs.	Proline	31-34	solute carrier family 36 member 1	Sus scrofa	109-116
34258421-7	2021	Oral administration of Put and Pro decreased (P < 0.05) serum ALP levels and increased (P < 0.05) intestinal SLC36A1 and SLC1A1 mRNA abundances and mTOR pathway phosphorylation levels in post-weaning pigs.	Proline	31-34	solute carrier family 1 member 1	Sus scrofa	121-127
34217162-7	2021	Glycine, serine and threonine metabolism, arginine and proline metabolism, TGF-beta signaling pathway, and pathways in cancer were significantly enriched in DEGs2 and DEGs4.	Proline	55-62	delta 4-desaturase, sphingolipid 2	Homo sapiens	157-162
34258421-7	2021	Oral administration of Put and Pro decreased (P < 0.05) serum ALP levels and increased (P < 0.05) intestinal SLC36A1 and SLC1A1 mRNA abundances and mTOR pathway phosphorylation levels in post-weaning pigs.	Proline	31-34	mechanistic target of rapamycin kinase	Sus scrofa	148-152
34258421-9	2021	These findings indicated that early-weaning dramatically altered the biochemical blood metabolites, AA profile and intestinal mTOR pathway activity, and Pro and Put supplementations improved the AA metabolism and transportation as well as activated the intestinal mTOR pathway in weanling-pigs.	Proline	153-156	mechanistic target of rapamycin kinase	Sus scrofa	264-268
34123975-9	2021	Both variations are missense mutations and locate in catalytic domain of PERK; c.2818C>T resulted in a residue substitution of proline for serine at amino acid site 940 (p.Pro940Ser), and variation c.2980G>C caused an amino acid change at position 994 from glutamic acid to glutamine (p.Glu994Gln).	Proline	127-134	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	73-77
34124074-4	2021	The Nck SH3 domains interact with signaling effectors containing proline-rich regions that mediate their activation by upstream kinases.	Proline	65-72	NCK adaptor protein 1	Homo sapiens	4-7
34095107-10	2021	Interestingly, PREP disruption inhibited p-ERK and p-p65 and reduced the levels of proinflammatory cytokines in response to endotoxin and proline-glycine-proline, which guided macrophage/neutrophil infiltration in mice fed a HFD for 24 weeks.	Proline	138-145	prolyl endopeptidase	Mus musculus	15-19
34095107-10	2021	Interestingly, PREP disruption inhibited p-ERK and p-p65 and reduced the levels of proinflammatory cytokines in response to endotoxin and proline-glycine-proline, which guided macrophage/neutrophil infiltration in mice fed a HFD for 24 weeks.	Proline	154-161	prolyl endopeptidase	Mus musculus	15-19
34095107-10	2021	Interestingly, PREP disruption inhibited p-ERK and p-p65 and reduced the levels of proinflammatory cytokines in response to endotoxin and proline-glycine-proline, which guided macrophage/neutrophil infiltration in mice fed a HFD for 24 weeks.	Proline	154-161	mitogen-activated protein kinase 1	Mus musculus	43-46
34095107-10	2021	Interestingly, PREP disruption inhibited p-ERK and p-p65 and reduced the levels of proinflammatory cytokines in response to endotoxin and proline-glycine-proline, which guided macrophage/neutrophil infiltration in mice fed a HFD for 24 weeks.	Proline	154-161	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	53-56
34065672-8	2021	The top KLK6-interaction partners were found to be the members of kallikrein family (KLK7, KLK8, KLK10), extracellular matrix associated proteins (keratins, integrins, small proline rich repeat, S100A families) and TGF-beta, FOS, and Ser/Thr protein kinase signaling pathways.	Proline	174-181	kallikrein related peptidase 6	Homo sapiens	8-12
34065603-5	2021	The analyses revealed that critical amino acids, namely Gly, Pro, Ala and Trp, were placed at distinct locations in the higher order structure of PPR domains.	Proline	61-64	PPR1	Homo sapiens	146-149
34067570-6	2021	These effects of proline (0.5 mmol/L) were accompanied by the enhanced protein abundance of p-mTORC1, p-p70S6K, p-S6, and p-4E-BP1.	Proline	17-24	CREB regulated transcription coactivator 1	Mus musculus	94-100
34067570-6	2021	These effects of proline (0.5 mmol/L) were accompanied by the enhanced protein abundance of p-mTORC1, p-p70S6K, p-S6, and p-4E-BP1.	Proline	17-24	ribosomal protein S6 kinase B1	Homo sapiens	104-110
34067570-6	2021	These effects of proline (0.5 mmol/L) were accompanied by the enhanced protein abundance of p-mTORC1, p-p70S6K, p-S6, and p-4E-BP1.	Proline	17-24	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	124-130
34067570-7	2021	Additionally, proline dose-dependently enhanced the mRNA expression of proline transporters (solute carrier family (SLC) 6A20, SLC36A1, SLC36A2, SLC38A1, and SLC38A2), elevated proline concentration, and protein abundance of proline dehydrogenase (PRODH).	Proline	14-21	solute carrier family 36 member 1	Homo sapiens	127-134
34067570-7	2021	Additionally, proline dose-dependently enhanced the mRNA expression of proline transporters (solute carrier family (SLC) 6A20, SLC36A1, SLC36A2, SLC38A1, and SLC38A2), elevated proline concentration, and protein abundance of proline dehydrogenase (PRODH).	Proline	14-21	solute carrier family 36 member 2	Homo sapiens	136-143
34067570-7	2021	Additionally, proline dose-dependently enhanced the mRNA expression of proline transporters (solute carrier family (SLC) 6A20, SLC36A1, SLC36A2, SLC38A1, and SLC38A2), elevated proline concentration, and protein abundance of proline dehydrogenase (PRODH).	Proline	14-21	solute carrier family 38 member 1	Homo sapiens	145-152
34067570-7	2021	Additionally, proline dose-dependently enhanced the mRNA expression of proline transporters (solute carrier family (SLC) 6A20, SLC36A1, SLC36A2, SLC38A1, and SLC38A2), elevated proline concentration, and protein abundance of proline dehydrogenase (PRODH).	Proline	14-21	solute carrier family 38 member 2	Homo sapiens	158-165
34067570-7	2021	Additionally, proline dose-dependently enhanced the mRNA expression of proline transporters (solute carrier family (SLC) 6A20, SLC36A1, SLC36A2, SLC38A1, and SLC38A2), elevated proline concentration, and protein abundance of proline dehydrogenase (PRODH).	Proline	14-21	proline dehydrogenase 1	Homo sapiens	225-246
34067570-7	2021	Additionally, proline dose-dependently enhanced the mRNA expression of proline transporters (solute carrier family (SLC) 6A20, SLC36A1, SLC36A2, SLC38A1, and SLC38A2), elevated proline concentration, and protein abundance of proline dehydrogenase (PRODH).	Proline	14-21	proline dehydrogenase 1	Homo sapiens	248-253
34067570-9	2021	Of note, proline resulted in lower reactive oxygen species (ROS) level, upregulated mRNA expression of the catalytic subunit of glutamate-cysteine ligase (GCLC) and glutathione synthetase (GSS), as well as enhanced total (T)-GSH and GSH concentration when compared with a control.	Proline	9-16	glutamate-cysteine ligase catalytic subunit	Homo sapiens	155-159
34067570-9	2021	Of note, proline resulted in lower reactive oxygen species (ROS) level, upregulated mRNA expression of the catalytic subunit of glutamate-cysteine ligase (GCLC) and glutathione synthetase (GSS), as well as enhanced total (T)-GSH and GSH concentration when compared with a control.	Proline	9-16	glutathione synthetase	Homo sapiens	165-187
34067570-9	2021	Of note, proline resulted in lower reactive oxygen species (ROS) level, upregulated mRNA expression of the catalytic subunit of glutamate-cysteine ligase (GCLC) and glutathione synthetase (GSS), as well as enhanced total (T)-GSH and GSH concentration when compared with a control.	Proline	9-16	glutathione synthetase	Homo sapiens	189-192
34132943-4	2021	The selective signature analysis demonstrated that GLIS1, LOC101117953, PDGFD and T were in the significant divergent regions between DS and STH-MG. A nonsynonymous point mutation (g.27807636G>T) was found within GLIS1 in STH-MG and resulted in a Pro to Thr substitution.	Proline	247-250	zinc finger protein GLIS1	Ovis aries	51-56
34132943-4	2021	The selective signature analysis demonstrated that GLIS1, LOC101117953, PDGFD and T were in the significant divergent regions between DS and STH-MG. A nonsynonymous point mutation (g.27807636G>T) was found within GLIS1 in STH-MG and resulted in a Pro to Thr substitution.	Proline	247-250	zinc finger protein GLIS1	Ovis aries	213-218
34251644-6	2021	Although Arg is formed de novo from glutamine/glutamate and proline in humans, these synthetic pathways do not provide sufficient Arg in infants or adults.	Proline	60-67	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	9-12
34602555-11	2021	In cultured cardiac fibroblasts, alpha-man significantly suppressed TGF-beta-induced increases in L-proline incorporation, mRNA levels (POSTN and alpha-smooth muscle actin (alpha-SMA)), and myofibroblast differentiation.	Proline	98-107	transforming growth factor alpha	Rattus norvegicus	68-76
34193686-2	2021	STAP-2 contains a pleckstrin homology domain at the N-terminus, an src homology domain in the central portion and a proline-rich region at the C-terminus.	Proline	116-123	signal transducing adaptor family member 2	Homo sapiens	0-6
34853228-9	2021	Furthermore, PTV significantly suppressed the angiotensin-II-induced proline incorporation in primary cultured cardiac fibroblasts.	Proline	69-76	angiotensinogen	Homo sapiens	46-60
34459410-1	2021	BACKGROUND: The Huntingtin (HTT) N-terminal domains encoded by Huntingtin"s (HTT) exon 1 consist of an N17 domain, the polyglutamine (polyQ) stretch and a proline-rich region (PRR).	Proline	155-162	huntingtin	Mus musculus	16-26
34459410-1	2021	BACKGROUND: The Huntingtin (HTT) N-terminal domains encoded by Huntingtin"s (HTT) exon 1 consist of an N17 domain, the polyglutamine (polyQ) stretch and a proline-rich region (PRR).	Proline	155-162	huntingtin	Mus musculus	28-31
34459410-1	2021	BACKGROUND: The Huntingtin (HTT) N-terminal domains encoded by Huntingtin"s (HTT) exon 1 consist of an N17 domain, the polyglutamine (polyQ) stretch and a proline-rich region (PRR).	Proline	155-162	huntingtin	Mus musculus	63-73
34459410-1	2021	BACKGROUND: The Huntingtin (HTT) N-terminal domains encoded by Huntingtin"s (HTT) exon 1 consist of an N17 domain, the polyglutamine (polyQ) stretch and a proline-rich region (PRR).	Proline	155-162	huntingtin	Mus musculus	77-80
35526712-3	2022	The limiting processes were hydrolysis and acidogenesis for the higher Car/Pro ratio of 3 and lower Car/Pro ratio of 0.25, respectively.	Proline	75-78	CXADR pseudogene 1	Homo sapiens	71-74
35526712-3	2022	The limiting processes were hydrolysis and acidogenesis for the higher Car/Pro ratio of 3 and lower Car/Pro ratio of 0.25, respectively.	Proline	104-107	CXADR pseudogene 1	Homo sapiens	100-103
35357776-1	2022	Pin1 catalyzes the cis-trans isomerization of pThr-Pro or pSer-Pro amide bonds of different proteins involved in several physio/pathological processes.	Proline	51-54	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
35604400-4	2022	Previous studies showed that these isomers might originate from a proline cis/trans isomerization in one Fab subunit of the tsAb.	Proline	66-73	FA complementation group B	Homo sapiens	105-108
35452957-5	2022	The region of p62 where NEDD4 binds is located at the proline- and arginine (PR)-rich region (amino acids: 102-119), C-terminal extension of the Phox and Bem1 (PB1) domain.	Proline	54-61	sequestosome 1	Homo sapiens	14-17
35452957-5	2022	The region of p62 where NEDD4 binds is located at the proline- and arginine (PR)-rich region (amino acids: 102-119), C-terminal extension of the Phox and Bem1 (PB1) domain.	Proline	54-61	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	24-29
35446349-3	2022	Here, we demonstrated that transportin-1 (TNPO1, also known as Karyopherin beta2 or Kapbeta2) targets an atypical C-terminal proline-tyrosine nuclear localization signal (PY-NLS) motif of BAP1 and serves as the primary nuclear transporter of BAP1 to achieve its nuclear import.	Proline	125-132	transportin 1	Homo sapiens	27-40
35446349-3	2022	Here, we demonstrated that transportin-1 (TNPO1, also known as Karyopherin beta2 or Kapbeta2) targets an atypical C-terminal proline-tyrosine nuclear localization signal (PY-NLS) motif of BAP1 and serves as the primary nuclear transporter of BAP1 to achieve its nuclear import.	Proline	125-132	transportin 1	Homo sapiens	42-47
35446349-3	2022	Here, we demonstrated that transportin-1 (TNPO1, also known as Karyopherin beta2 or Kapbeta2) targets an atypical C-terminal proline-tyrosine nuclear localization signal (PY-NLS) motif of BAP1 and serves as the primary nuclear transporter of BAP1 to achieve its nuclear import.	Proline	125-132	transportin 1	Homo sapiens	63-80
35446349-3	2022	Here, we demonstrated that transportin-1 (TNPO1, also known as Karyopherin beta2 or Kapbeta2) targets an atypical C-terminal proline-tyrosine nuclear localization signal (PY-NLS) motif of BAP1 and serves as the primary nuclear transporter of BAP1 to achieve its nuclear import.	Proline	125-132	BRCA1 associated protein 1	Homo sapiens	188-192
35446349-3	2022	Here, we demonstrated that transportin-1 (TNPO1, also known as Karyopherin beta2 or Kapbeta2) targets an atypical C-terminal proline-tyrosine nuclear localization signal (PY-NLS) motif of BAP1 and serves as the primary nuclear transporter of BAP1 to achieve its nuclear import.	Proline	125-132	BRCA1 associated protein 1	Homo sapiens	242-246
35142150-0	2022	Proline-rich tyrosine kinase Pyk2 regulates deep vein thrombosis.	Proline	0-7	PTK2 protein tyrosine kinase 2 beta	Mus musculus	29-33
35466425-4	2022	Proline supplementation rescues the observed HF-induced changes indicating that they result from inhibition of EPRS.	Proline	0-7	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	111-115
35142150-2	2022	The proline-rich tyrosine kinase Pyk2 regulates platelet activation and supports arterial thrombosis.	Proline	4-11	PTK2 protein tyrosine kinase 2 beta	Mus musculus	33-37
35575118-0	2022	A novel substitution of proline (P32L) destabilises beta2-microglobulin inducing hereditary systemic amyloidosis.	Proline	24-31	beta-2-microglobulin	Homo sapiens	52-71
35381286-7	2022	Mechanistic studies reveal that 14-3-3zeta regulates tau LLPS by electrostatic interactions and hydrophobic interactions with the proline-rich domain and the microtubule-binding domain of tau.	Proline	130-137	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	32-42
35381286-7	2022	Mechanistic studies reveal that 14-3-3zeta regulates tau LLPS by electrostatic interactions and hydrophobic interactions with the proline-rich domain and the microtubule-binding domain of tau.	Proline	130-137	microtubule associated protein tau	Homo sapiens	53-56
35381286-7	2022	Mechanistic studies reveal that 14-3-3zeta regulates tau LLPS by electrostatic interactions and hydrophobic interactions with the proline-rich domain and the microtubule-binding domain of tau.	Proline	130-137	microtubule associated protein tau	Homo sapiens	188-191
35511597-2	2022	In this study, a prolyl endopeptidase (APE) from Aspergillus niger, which could degrade approximately 50% of the B3 subunit and increase proline content by 24% in soy sauce, was isolated and identified.	Proline	137-144	prolyl endopeptidase	Glycine max	17-37
35213728-9	2022	Intriguingly, when all data were pooled, variations in CTX and PINP levels were positively correlated with fluctuations in proline and glycine concentrations (r>0.5 or 0.3<r<0.5, p<0.05).	Proline	123-130	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	55-58
35575289-7	2022	Mutations at the spike residue P681 in several strains, such P681R in the Delta strain, resulted in the disruption of a proline-directed kinase phosphorylation motif at the S1/S2 site, which may lessen the impact of phosphorylation for these variants.	Proline	120-127	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	17-22
35231586-0	2022	Addition of arginine hydrochloride and proline to the culture medium enhances recombinant protein expression in Brevibacillus choshinensis: The case of RBD of SARS-CoV-2 spike protein and its antibody.	Proline	39-46	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	170-175
35604110-8	2022	Importantly, CLEC16A stability is dependent on proline bias within the C-terminal IDPR, but not amino acid sequence order or charge.	Proline	47-54	C-type lectin domain containing 16A	Homo sapiens	13-20
35521963-1	2022	The naturally occurring imino acid azetidine-2-carboxylic acid (Aze) is consumed by humans and can be misincorporated in place of proline in myelin basic protein (MBP) in vitro.	Proline	130-137	myelin basic protein	Homo sapiens	141-161
35521963-1	2022	The naturally occurring imino acid azetidine-2-carboxylic acid (Aze) is consumed by humans and can be misincorporated in place of proline in myelin basic protein (MBP) in vitro.	Proline	130-137	myelin basic protein	Homo sapiens	163-166
35595097-6	2022	We found that the substitution of proline with leucine by apem7 mutation alters ubiquitination of PEX4.	Proline	34-41	peroxin4	Arabidopsis thaliana	98-102
35546540-4	2022	Proline is degraded by proline dehydrogenase (PutA) into pyrroline-5-carboxylate (P5C).	Proline	0-7	AT695_RS08650	Staphylococcus aureus	23-44
35568694-4	2022	Through investigation of RBM38 phosphorylation, we found that the eIF4E2-GSK3beta pathway specifically regulated proline-directed serine/threonine phosphorylation (S/T-P).	Proline	113-120	RNA binding motif protein 38	Homo sapiens	25-30
35568694-4	2022	Through investigation of RBM38 phosphorylation, we found that the eIF4E2-GSK3beta pathway specifically regulated proline-directed serine/threonine phosphorylation (S/T-P).	Proline	113-120	eukaryotic translation initiation factor 4E family member 2	Homo sapiens	66-72
35568694-4	2022	Through investigation of RBM38 phosphorylation, we found that the eIF4E2-GSK3beta pathway specifically regulated proline-directed serine/threonine phosphorylation (S/T-P).	Proline	113-120	glycogen synthase kinase 3 alpha	Homo sapiens	73-81
35617919-0	2022	The CD8alpha hinge is intrinsically disordered with a dynamic exchange that includes proline cis-trans isomerization.	Proline	85-92	CD8a molecule	Homo sapiens	4-12
35532281-3	2022	On the loop, which connects the two hairpin alpha-helix of c subunit, is present the unique proline residue (Pro40 ) that could be a biological target of CyPD.	Proline	92-99	peptidylprolyl isomerase D	Homo sapiens	154-158
35508574-5	2022	Our results reveal that the proline-rich (P-rich) loop of MEK1 plays a decisive role in MEK1 activation loop (A-loop) phosphorylation.	Proline	28-35	mitogen-activated protein kinase kinase 1	Homo sapiens	58-62
35561654-10	2022	Therefore, aromatic heterocycles incorporated with trizole could serve as a promising HBM for Bcr-Abl inhibitors with proline as fexibile linker, and compounds 9f, 28c, especially 44c could be served as a starting point for further optimization.	Proline	118-125	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	94-101
35290795-7	2022	We conclude that interactions with NT* help to unblock translation of the proline-rich disordered region of p53.	Proline	74-81	tumor protein p53	Homo sapiens	108-111
35510485-11	2022	CONCLUSIONS: The alanine, valine and isoleucine (AVI) as well as proline, alanine and valine (PAV) haplotypes of the TAS2R38 gene are associated with the DMFT/dmft index and obesity.	Proline	65-72	taste 2 receptor member 38	Homo sapiens	117-124
35508574-5	2022	Our results reveal that the proline-rich (P-rich) loop of MEK1 plays a decisive role in MEK1 activation loop (A-loop) phosphorylation.	Proline	28-35	mitogen-activated protein kinase kinase 1	Homo sapiens	88-92
35499266-1	2022	Purpose: The purpose of this paper is to investigate how the imbalance of neurogenic factor (NGF) and its precursor (pro-NGF) mediates structural and functional impairment of retinal neurovascular unit (RNVU) that plays a role in retinal degenerative diseases.Methods: A literature search of electronic databases was performed.Results: The pro-apoptotic effect of pro-NGF and the pro-growth effect of NGF are essential for the pathological and physiological activities of RNVU.	Proline	364-367	nerve growth factor	Homo sapiens	93-96
35563503-1	2022	The oxidation of proline to pyrroline-5-carboxylate (P5C) leads to the transfer of electrons to ubiquinone in mitochondria that express proline dehydrogenase (ProDH).	Proline	17-24	proline dehydrogenase	Mus musculus	136-157
35563503-1	2022	The oxidation of proline to pyrroline-5-carboxylate (P5C) leads to the transfer of electrons to ubiquinone in mitochondria that express proline dehydrogenase (ProDH).	Proline	17-24	proline dehydrogenase	Mus musculus	159-164
35563503-12	2022	The ProDH inhibitors tetrahydro-2-furoic acid and, to a lesser extent, S-5-oxo-2-tetrahydrofurancarboxylic acid abolished all proline effects.	Proline	126-133	proline dehydrogenase	Mus musculus	4-9
35563503-13	2022	The data show that ProDH-directed proline catabolism could generate sufficient CIII and CIV proton pumping, thus supporting ATP production by the F1FO-ATPase even under CI inhibition.	Proline	34-41	proline dehydrogenase	Mus musculus	19-24
35505422-4	2022	These mutations are predicted to cause Serine (c.193T > C) to Proline and Tryptophan (c.194C > G) substitution at residue 65 of VHL protein (p.Ser65Pro and Ser65Trp).	Proline	62-69	von Hippel-Lindau tumor suppressor	Homo sapiens	128-131
35508109-4	2022	Microbial functions and metabolites converging onto glutamate/GABA metabolism, particularly proline, were linked to depression.	Proline	92-99	Resistant to dieldrin	Drosophila melanogaster	62-66
35383292-0	2022	The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein.	Proline	58-65	tumor protein p53	Homo sapiens	80-83
35499085-6	2022	P3H2 hydroxylates the 3" of prolines in collagen IV subchains in the endoplasmic reticulum.	Proline	28-36	prolyl 3-hydroxylase 2	Homo sapiens	0-4
35468885-2	2022	An important group of enzymes has been deprived of this analytical privilege: members of the protein tyrosine phosphatase (PTP) superfamily with catalytic WPD-loops lacking the indispensable general-acid/base within a tryptophan-proline-aspartate/glutamate context.	Proline	229-236	protein-tyrosine phosphatase	Arabidopsis thaliana	93-121
35567218-9	2022	Increased proline content and enzymatic antioxidants, including superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxide (APX), were found to alleviate oxidative damage under chilling stress.	Proline	10-17	superoxide dismutase 1	Homo sapiens	64-84
35567218-9	2022	Increased proline content and enzymatic antioxidants, including superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxide (APX), were found to alleviate oxidative damage under chilling stress.	Proline	10-17	superoxide dismutase 1	Homo sapiens	86-89
35567218-9	2022	Increased proline content and enzymatic antioxidants, including superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxide (APX), were found to alleviate oxidative damage under chilling stress.	Proline	10-17	catalase	Homo sapiens	92-100
35567218-9	2022	Increased proline content and enzymatic antioxidants, including superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxide (APX), were found to alleviate oxidative damage under chilling stress.	Proline	10-17	catalase	Homo sapiens	102-105
35165443-5	2022	CQ31 inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the accumulation of proline-containing peptides that inhibit DPP8/9 and thereby activate CARD8.	Proline	127-134	peptidase D	Homo sapiens	39-48
35165443-5	2022	CQ31 inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the accumulation of proline-containing peptides that inhibit DPP8/9 and thereby activate CARD8.	Proline	127-134	peptidase D	Homo sapiens	50-54
35165443-5	2022	CQ31 inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the accumulation of proline-containing peptides that inhibit DPP8/9 and thereby activate CARD8.	Proline	127-134	X-prolyl aminopeptidase 1	Homo sapiens	60-84
35165443-5	2022	CQ31 inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the accumulation of proline-containing peptides that inhibit DPP8/9 and thereby activate CARD8.	Proline	127-134	X-prolyl aminopeptidase 1	Homo sapiens	86-93
35165443-5	2022	CQ31 inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the accumulation of proline-containing peptides that inhibit DPP8/9 and thereby activate CARD8.	Proline	127-134	dipeptidyl peptidase 8	Homo sapiens	168-174
35165443-5	2022	CQ31 inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the accumulation of proline-containing peptides that inhibit DPP8/9 and thereby activate CARD8.	Proline	127-134	caspase recruitment domain family member 8	Homo sapiens	196-201
35165443-6	2022	NLRP1 is distinct from CARD8 in that it directly contacts DPP8/9"s active site; these proline-containing peptides, unlike VbP, do not disrupt this repressive interaction and thus do not activate NLRP1.	Proline	86-93	NLR family pyrin domain containing 1	Homo sapiens	0-5
35468885-2	2022	An important group of enzymes has been deprived of this analytical privilege: members of the protein tyrosine phosphatase (PTP) superfamily with catalytic WPD-loops lacking the indispensable general-acid/base within a tryptophan-proline-aspartate/glutamate context.	Proline	229-236	protein-tyrosine phosphatase	Arabidopsis thaliana	123-126
35385313-4	2022	In the absence of FGF21, a large part of the metabolic adaptation to mitochondrial dysfunction (one-carbon metabolism, transsulfuration, and serine and proline biosynthesis) is strongly blunted, independent of the primary mitoISR activator ATF4.	Proline	152-159	fibroblast growth factor 21	Homo sapiens	18-23
35460691-2	2022	Over the past decade, human ornithine aminotransferase (hOAT), which is an enzyme that catalyzes the metabolic conversion of ornithine into an intermediate for proline or glutamate synthesis, has been found to be overexpressed in HCC cells.	Proline	160-167	ornithine aminotransferase	Homo sapiens	28-54
35572751-0	2022	Conserved Apical Proline Regulating the Structure and DNA Binding Properties of Helicobacter pylori Histone-like DNA Binding Protein (Hup).	Proline	17-24	zinc finger protein 763	Homo sapiens	113-132
35572751-8	2022	This comprehensive study dissected the exclusive role of evolutionarily conserved apical proline residue in regulating the structure and DNA binding of Hup protein as P64 is presumed to be involved in the external leverage mechanism responsible for DNA bending and packaging, as proline rings wedge into the DNA backbone through intercalation besides their significant role in DNA binding.	Proline	89-96	interleukin 2 receptor subunit gamma	Homo sapiens	167-170
35572751-8	2022	This comprehensive study dissected the exclusive role of evolutionarily conserved apical proline residue in regulating the structure and DNA binding of Hup protein as P64 is presumed to be involved in the external leverage mechanism responsible for DNA bending and packaging, as proline rings wedge into the DNA backbone through intercalation besides their significant role in DNA binding.	Proline	279-286	interleukin 2 receptor subunit gamma	Homo sapiens	167-170
35454935-5	2022	RESULTS: The role of the proline cycle in maintaining redox balance in IDH-mutated gliomas has been convincingly demonstrated.	Proline	25-32	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	71-74
35465102-4	2022	The TRITC modification was located on the N-terminal proline of the protein macrophage migration inhibitory factor (MIF).	Proline	53-60	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	76-114
35465102-4	2022	The TRITC modification was located on the N-terminal proline of the protein macrophage migration inhibitory factor (MIF).	Proline	53-60	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	116-119
35448505-9	2022	Moreover, plasma proline fold-change was found to be positively correlated with cTnT and cytokine fold-changes, and trans-4-hydroxyproline (t4-OH-Pro) fold-change was positively correlated with cTnT fold-change.	Proline	17-24	troponin T2, cardiac type	Homo sapiens	80-84
35386021-7	2022	Regression analysis and correspondence analysis (CA) confirmed that the expression profiles of the OMT1 gene and variations in melatonin content, antioxidant enzyme activities, proline accumulation, H2O2 and malondialdehyde (MDA) contents are significantly associated with combined stress tolerance.	Proline	177-184	flavone O-methyltransferase 1	Triticum aestivum	99-103
35276062-0	2022	A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy.	Proline	72-79	CD8a molecule	Homo sapiens	49-52
35276062-0	2022	A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy.	Proline	72-79	nuclear receptor subfamily 1 group I member 3	Homo sapiens	113-116
35008129-1	2022	Six proline-derived acetylene monomers bearing either two stereocenters (S-mR, S-mS, R-mS, Rac-mS and S-mRac) or one stereocenter (S-mBn) were obtained from commercially available N-(tert-butoxycarbonyl)-prolinal.	Proline	4-11	AKT serine/threonine kinase 1	Homo sapiens	91-94
35176225-7	2022	Furthermore, our findings indicated that ecologically relevant high concentrations of arginine, lysine, proline, valine, tryptophan, isoleucine, and leucine elicit aversive responses via bitter-sensing GRNs, which are mediated by three IRs (IR25a, IR51b, and IR76b).	Proline	104-111	Ionotropic receptor 76b	Drosophila melanogaster	259-264
35478031-2	2022	Prolidase, also known as peptidase D (PEPD), plays a vital role in collagen turnover by degrading proline-containing dipeptides but its specific functional relevance in AT is unknown.	Proline	98-105	peptidase D	Mus musculus	0-9
35478031-2	2022	Prolidase, also known as peptidase D (PEPD), plays a vital role in collagen turnover by degrading proline-containing dipeptides but its specific functional relevance in AT is unknown.	Proline	98-105	peptidase D	Mus musculus	25-36
35478031-2	2022	Prolidase, also known as peptidase D (PEPD), plays a vital role in collagen turnover by degrading proline-containing dipeptides but its specific functional relevance in AT is unknown.	Proline	98-105	peptidase D	Mus musculus	38-42
35453378-5	2022	Under drought stress, wheat seedlings responded in proline accumulation that was correlated with the P5CS gene expression.	Proline	51-58	aldehyde dehydrogenase 18 family member A1	Homo sapiens	101-105
35176225-7	2022	Furthermore, our findings indicated that ecologically relevant high concentrations of arginine, lysine, proline, valine, tryptophan, isoleucine, and leucine elicit aversive responses via bitter-sensing GRNs, which are mediated by three IRs (IR25a, IR51b, and IR76b).	Proline	104-111	Ionotropic receptor 25a	Drosophila melanogaster	241-246
35401684-3	2022	Although it also binds to Max, Mxi1-0, unlike other Mxi1 isoforms, cannot antagonize the oncoprotein c-Myc because of its unique proline rich domain (PRD).	Proline	129-136	MAX interactor 1, dimerization protein	Homo sapiens	52-56
35176225-7	2022	Furthermore, our findings indicated that ecologically relevant high concentrations of arginine, lysine, proline, valine, tryptophan, isoleucine, and leucine elicit aversive responses via bitter-sensing GRNs, which are mediated by three IRs (IR25a, IR51b, and IR76b).	Proline	104-111	Ionotropic receptor 51b	Drosophila melanogaster	248-253
35453325-4	2022	Our objective was to describe the kinetics of four biomarkers related to pro-oxidative processes (nitrite/nitrate, malondialdehyde, 8-oxo-2"-deoxyguanosine, soluble endoglin) compared to four biomarkers of antioxidant processes (the ferric reducing ability of plasma, superoxide dismutase, asymmetric dimethylarginine, mid-regional pro-adrenomedullin) and four inflammatory biomarkers (CRP, IL-6, IL-10 and neopterin).	Proline	73-76	endoglin	Homo sapiens	165-173
35453325-4	2022	Our objective was to describe the kinetics of four biomarkers related to pro-oxidative processes (nitrite/nitrate, malondialdehyde, 8-oxo-2"-deoxyguanosine, soluble endoglin) compared to four biomarkers of antioxidant processes (the ferric reducing ability of plasma, superoxide dismutase, asymmetric dimethylarginine, mid-regional pro-adrenomedullin) and four inflammatory biomarkers (CRP, IL-6, IL-10 and neopterin).	Proline	73-76	C-reactive protein	Homo sapiens	386-389
35453325-4	2022	Our objective was to describe the kinetics of four biomarkers related to pro-oxidative processes (nitrite/nitrate, malondialdehyde, 8-oxo-2"-deoxyguanosine, soluble endoglin) compared to four biomarkers of antioxidant processes (the ferric reducing ability of plasma, superoxide dismutase, asymmetric dimethylarginine, mid-regional pro-adrenomedullin) and four inflammatory biomarkers (CRP, IL-6, IL-10 and neopterin).	Proline	73-76	interleukin 6	Homo sapiens	391-395
35453325-4	2022	Our objective was to describe the kinetics of four biomarkers related to pro-oxidative processes (nitrite/nitrate, malondialdehyde, 8-oxo-2"-deoxyguanosine, soluble endoglin) compared to four biomarkers of antioxidant processes (the ferric reducing ability of plasma, superoxide dismutase, asymmetric dimethylarginine, mid-regional pro-adrenomedullin) and four inflammatory biomarkers (CRP, IL-6, IL-10 and neopterin).	Proline	73-76	interleukin 10	Homo sapiens	397-402
35399536-0	2022	C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response.	Proline	16-23	C9orf72-SMCR8 complex subunit	Homo sapiens	0-7
35399536-1	2022	Proline:arginine (PR) poly-dipeptides from the GGGGCC repeat expansion in C9orf72 have cytotoxicity and bind intermediate filaments (IFs).	Proline	0-7	C9orf72-SMCR8 complex subunit	Homo sapiens	74-81
35401684-3	2022	Although it also binds to Max, Mxi1-0, unlike other Mxi1 isoforms, cannot antagonize the oncoprotein c-Myc because of its unique proline rich domain (PRD).	Proline	129-136	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	101-106
35274674-12	2022	Next, we assessed splicing factor proline/glutamine rich (SFPQ) expression in spinal cord motor neurons; SFPQ is a recently-identified regulator of ALS/FTLD pathogenesis, and it is also reported that interaction between SFPQ and fused-in-sarcoma (FUS) regulates splicing of microtubule-associated protein tau exon 10.	Proline	34-41	splicing factor proline and glutamine rich	Homo sapiens	58-62
35188576-6	2022	We also revealed that such a drop-off-reinitiation event can be alleviated by EF-P that promotes peptidyl transfer of Pro.	Proline	118-121	tripartite motif containing 25	Homo sapiens	78-82
35325178-5	2022	When coupled with the amyotrophic lateral sclerosis (ALS)-associated C9ORF72 proline/arginine-rich dipeptide repeats, pNUTs allow us to photomanipulate poly-proline-arginine nucleolar localization, perturb nucleolar protein nucleophosmin 1 and suppress nascent protein synthesis.	Proline	77-84	C9orf72-SMCR8 complex subunit	Homo sapiens	69-76
35325178-5	2022	When coupled with the amyotrophic lateral sclerosis (ALS)-associated C9ORF72 proline/arginine-rich dipeptide repeats, pNUTs allow us to photomanipulate poly-proline-arginine nucleolar localization, perturb nucleolar protein nucleophosmin 1 and suppress nascent protein synthesis.	Proline	77-84	protein phosphatase 1 regulatory subunit 10	Homo sapiens	118-123
35312915-5	2022	When U concentration was 25 muM, superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD) activities in radish were increased to cope with the oxidative stress caused by U stress, and the accumulation of proline and soluble sugar was increased to maintain cell turgor.	Proline	211-218	peroxidase E5-like	Raphanus sativus	92-95
35179207-8	2022	At the centre, the second proline was substituted by WNK3 Thr541, providing a unique phosphorylatable residue among the WNK-family degrons.	Proline	26-33	WNK lysine deficient protein kinase 3	Homo sapiens	53-57
35286254-1	2022	The bifunctional enzyme Delta1-pyrroline-5-carboxylate synthase (P5CS) is vital to the synthesis of proline and ornithine, playing an essential role in human health and agriculture.	Proline	100-107	aldehyde dehydrogenase 18 family member A1	Homo sapiens	24-63
35286254-1	2022	The bifunctional enzyme Delta1-pyrroline-5-carboxylate synthase (P5CS) is vital to the synthesis of proline and ornithine, playing an essential role in human health and agriculture.	Proline	100-107	aldehyde dehydrogenase 18 family member A1	Homo sapiens	65-69
35274674-12	2022	Next, we assessed splicing factor proline/glutamine rich (SFPQ) expression in spinal cord motor neurons; SFPQ is a recently-identified regulator of ALS/FTLD pathogenesis, and it is also reported that interaction between SFPQ and fused-in-sarcoma (FUS) regulates splicing of microtubule-associated protein tau exon 10.	Proline	34-41	splicing factor proline and glutamine rich	Homo sapiens	105-109
35019717-2	2022	CD46 has several isoforms of which the most commonly expressed can be distinguished by expression of a BC domain or a C domain in a serine-threonine-proline rich (STP) extracellular region.	Proline	149-156	CD46 molecule	Homo sapiens	0-4
35261338-0	2022	SLC38A2 provides proline to fulfil unique synthetic demands arising during osteoblast differentiation and bone formation.	Proline	17-24	solute carrier family 38, member 2	Mus musculus	0-7
35261338-4	2022	When compared to other differentiated cells, osteoblast-associated proteins including RUNX2, OSX, OCN and COL1A1 are significantly enriched in proline.	Proline	143-150	runt related transcription factor 2	Mus musculus	86-91
35261338-4	2022	When compared to other differentiated cells, osteoblast-associated proteins including RUNX2, OSX, OCN and COL1A1 are significantly enriched in proline.	Proline	143-150	Sp7 transcription factor 7	Mus musculus	93-96
35261338-4	2022	When compared to other differentiated cells, osteoblast-associated proteins including RUNX2, OSX, OCN and COL1A1 are significantly enriched in proline.	Proline	143-150	collagen, type I, alpha 1	Mus musculus	106-112
35261338-5	2022	Using a genetic and metabolomic approach, we demonstrate that the neutral amino acid transporter SLC38A2 acts cell autonomously to provide proline to facilitate the efficient synthesis of proline-rich osteoblast proteins.	Proline	139-146	solute carrier family 38, member 2	Mus musculus	97-104
35261338-5	2022	Using a genetic and metabolomic approach, we demonstrate that the neutral amino acid transporter SLC38A2 acts cell autonomously to provide proline to facilitate the efficient synthesis of proline-rich osteoblast proteins.	Proline	188-195	solute carrier family 38, member 2	Mus musculus	97-104
35216470-7	2022	Of interest is an MET-dependent increase in the concentration of proline, which is a substrate for PRODH/POX.	Proline	65-72	SAFB like transcription modulator	Homo sapiens	18-21
35267786-5	2022	Results showed a high quality of the extracted-elastin with the presence of a high amount of proline (6.55 +- 0.40%) and glycine (9.65 +- 0.44%), low amount of hydroxyproline (0.80 +- 0.32%), methionine (2.04 +- 0.05%), and histidine (1.81 +- 0.05%) together with calculated 0.56 isoleucine/leucine ratio.	Proline	93-100	elastin	Bos taurus	47-54
35197125-1	2022	BACKGROUND: Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins, such as collagen.	Proline	197-204	peptidase D	Homo sapiens	120-124
35415275-6	2022	Heterodimeric HIF transcription factor activity is regulated post-translationally by selective PHD proline hydroxylation of its HIF1alpha subunit, accelerating HIF1alpha ubiquitination and proteasomal degradation, preventing HIF heterodimer assembly, nuclear accumulation, and activation of its target oxygen homeostasis genes.	Proline	99-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-137
35415275-6	2022	Heterodimeric HIF transcription factor activity is regulated post-translationally by selective PHD proline hydroxylation of its HIF1alpha subunit, accelerating HIF1alpha ubiquitination and proteasomal degradation, preventing HIF heterodimer assembly, nuclear accumulation, and activation of its target oxygen homeostasis genes.	Proline	99-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	160-169
35228649-4	2022	High salt intake under reduced NO production overactivated the angiotensin II-SPAK (STE20/SPS1-related proline-alanine-rich protein kinase)-NCC (sodium chloride co-transporter) pathway in the kidney, resulting in the insufficient excretion of sodium during the day and its excessive excretion at night.	Proline	103-110	serine/threonine kinase 39	Mus musculus	78-82
35228649-4	2022	High salt intake under reduced NO production overactivated the angiotensin II-SPAK (STE20/SPS1-related proline-alanine-rich protein kinase)-NCC (sodium chloride co-transporter) pathway in the kidney, resulting in the insufficient excretion of sodium during the day and its excessive excretion at night.	Proline	103-110	solute carrier family 12, member 3	Mus musculus	140-143
35216470-2	2022	PRODH/POX is a mitochondrial enzyme-degrading proline that is implicated in the regulation of cancer cell survival/apoptosis.	Proline	46-53	proline dehydrogenase 1	Homo sapiens	0-5
35216470-7	2022	Of interest is an MET-dependent increase in the concentration of proline, which is a substrate for PRODH/POX.	Proline	65-72	proline dehydrogenase 1	Homo sapiens	99-104
35216470-2	2022	PRODH/POX is a mitochondrial enzyme-degrading proline that is implicated in the regulation of cancer cell survival/apoptosis.	Proline	46-53	proline dehydrogenase 1	Homo sapiens	6-9
35216470-7	2022	Of interest is an MET-dependent increase in the concentration of proline, which is a substrate for PRODH/POX.	Proline	65-72	proline dehydrogenase 1	Homo sapiens	105-108
35216470-8	2022	This phenomenon is due to the MET-dependent inhibition of collagen biosynthesis, which is the main proline-utilizing process.	Proline	99-106	SAFB like transcription modulator	Homo sapiens	30-33
35216470-9	2022	It has been found that the underlying mechanism of anticancer activity of MET involves the activation of AMPK, PRODH/POX, increase in the cytoplasmic concentration of proline, inhibition of collagen biosynthesis, and stimulation of PRODH/POX-dependent ROS generation, which initiate the apoptosis of melanoma cells.	Proline	167-174	SAFB like transcription modulator	Homo sapiens	74-77
35130302-2	2022	The last step in the proline biosynthesis pathway is catalyzed by pyrroline-5-carboxylate reductase (PYCR) enzymes.	Proline	21-28	pyrroline-5-carboxylate reductase 1	Homo sapiens	66-99
34637888-4	2022	We observed that proline residues are preferentially removed from the proteome of prevalent mutants, leading to a predicted global loss of SARS-CoV-2 T cell epitopes in individuals expressing HLA-B alleles of the B7 supertype family; this is largely driven by a dominant C-to-U mutation type at the RNA level.	Proline	17-24	major histocompatibility complex, class I, B	Homo sapiens	192-197
35149717-6	2022	However, overexpression of a form of ASCL1 that cannot be phosphorylated on Serine-Proline sites drives GBM cells down a neuronal lineage and out of cell cycle more efficiently than its wild-type counterpart, an effect further enhanced by deletion of the inhibitor of differentiation ID2, indicating mechanisms to reverse the block to GBM cell differentiation.	Proline	83-90	achaete-scute family bHLH transcription factor 1	Homo sapiens	37-42
35124875-0	2022	The Effects of Proline Isomerization on the Solvation Behavior of Elastin-Like Polypeptides in Water-Ethanol Mixtures.	Proline	15-22	elastin	Homo sapiens	66-73
35169792-5	2022	A joint X-ray/neutron structure of the M pro /BBH-1 complex demonstrated that a Cys145 thiolate reaction with the inhibitora$ s keto-warhead creates a negatively charged oxyanion, similar to that proposed for the M pro -catalyzed peptide bond hydrolysis.	Proline	41-44	gamma-butyrobetaine hydroxylase 1	Homo sapiens	46-49
35243242-5	2022	Isotope tracing results showed that KRAS-G12D promotes catabolism of methionine and arginine to support anabolism of polyamines and proline, respectively.	Proline	132-139	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	36-40
35130302-2	2022	The last step in the proline biosynthesis pathway is catalyzed by pyrroline-5-carboxylate reductase (PYCR) enzymes.	Proline	21-28	pyrroline-5-carboxylate reductase 1	Homo sapiens	101-105
35205350-8	2022	The Drosophila RpL22 has additional Ala-, Lys- and Pro-rich sequences at the amino terminus, which resembles the carboxy-terminal portion of histone H1 and histone H5.	Proline	51-54	Ribosomal protein L22	Drosophila melanogaster	15-20
35148834-0	2022	Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4.	Proline	90-93	guanosine monophosphate reductase	Homo sapiens	19-52
35148834-0	2022	Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4.	Proline	90-93	EPH receptor A4	Homo sapiens	125-130
35186732-2	2022	PCNP is a short-living, small nuclear protein of only 178 amino acids with two remarkable PEST sequences that are rich in proline (P), glutamic acid (E), serine (S), and threonine (T).	Proline	122-129	PEST proteolytic signal containing nuclear protein	Homo sapiens	0-4
35072459-5	2022	The substrate (l-proline) is attached to the Bmp1(CP), and the catalytic site is located inside the flavin-dependent oxidase (Bmp3).	Proline	15-24	bone morphogenetic protein 1	Homo sapiens	45-49
34705620-9	2022	Knockdown of Plk1 reduced Casp9 phosphorylation at Ser-196, reduced pro-Casp9/3 expression and increased apoptosis.	Proline	68-71	polo like kinase 1	Homo sapiens	13-17
34705620-9	2022	Knockdown of Plk1 reduced Casp9 phosphorylation at Ser-196, reduced pro-Casp9/3 expression and increased apoptosis.	Proline	68-71	caspase 9	Homo sapiens	72-79
35108535-0	2022	Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	26-31
35072459-5	2022	The substrate (l-proline) is attached to the Bmp1(CP), and the catalytic site is located inside the flavin-dependent oxidase (Bmp3).	Proline	15-24	ceruloplasmin	Homo sapiens	50-52
35108535-4	2022	We show that in hypoxic conditions, mitochondrial pyrroline 5-carboxylate reductase 1 (PYCR1) activity is increased, oxidizing NADH with the synthesis of proline as a by-product.	Proline	154-161	pyrroline-5-carboxylate reductase 1	Homo sapiens	50-85
35108535-4	2022	We show that in hypoxic conditions, mitochondrial pyrroline 5-carboxylate reductase 1 (PYCR1) activity is increased, oxidizing NADH with the synthesis of proline as a by-product.	Proline	154-161	pyrroline-5-carboxylate reductase 1	Homo sapiens	87-92
35105345-4	2022	Pyrroline-5-carboxylate reductase 1 and 2 (PYCR1 and PYCR2) are two mitochondrial enzymes that facilitate the last step in the glutamine-to-proline conversion.	Proline	140-147	pyrroline-5-carboxylate reductase 1	Homo sapiens	43-48
35105345-4	2022	Pyrroline-5-carboxylate reductase 1 and 2 (PYCR1 and PYCR2) are two mitochondrial enzymes that facilitate the last step in the glutamine-to-proline conversion.	Proline	140-147	pyrroline-5-carboxylate reductase 2	Homo sapiens	53-58
35105345-17	2022	In line with the strong expression of PYCR1, we performed a tracer study in RPMI-8226 cells, which revealed an increased conversion of 13C-glutamine to proline in hypoxia.	Proline	152-159	pyrroline-5-carboxylate reductase 1	Homo sapiens	38-43
35163602-9	2022	In addition to lower malondialdehyde accumulation, the phyA mutant enhanced proline levels.	Proline	76-83	Phytochrome A	Solanum lycopersicum	55-59
35173752-5	2021	The results showed that with a decrease in soil moisture content, the content of malondialdehyde (MDA) in soybean leaves increased significantly; the activities of peroxidase (POD), catalase (CAT), and ascorbic acid peroxidase (APX) increased first and then decreased; the content of proline, soluble sugar, and soluble protein increased; and the total antioxidant capacity (T-AOC) increased significantly.	Proline	284-291	peroxidase	Glycine max	176-179
35159006-3	2022	PRCP is a lysosomal serine protease that cleaves peptide substrates when the penultimate amino acid is proline.	Proline	103-110	prolylcarboxypeptidase	Homo sapiens	0-4
35163433-4	2022	PRODH/POX is a mitochondrial enzyme that catalyzes proline degradation, during which ATP or reactive oxygen species (ROS) are generated.	Proline	51-58	proline dehydrogenase 1	Homo sapiens	0-5
35163433-4	2022	PRODH/POX is a mitochondrial enzyme that catalyzes proline degradation, during which ATP or reactive oxygen species (ROS) are generated.	Proline	51-58	proline dehydrogenase 1	Homo sapiens	6-9
35163433-6	2022	Simultaneously, the NSAIDs inhibited collagen biosynthesis, supporting proline for PRODH/POX-induced ROS-dependent apoptosis (as demonstrated by an increase in the expression of apoptosis markers).	Proline	71-78	proline dehydrogenase 1	Homo sapiens	83-88
35163433-6	2022	Simultaneously, the NSAIDs inhibited collagen biosynthesis, supporting proline for PRODH/POX-induced ROS-dependent apoptosis (as demonstrated by an increase in the expression of apoptosis markers).	Proline	71-78	proline dehydrogenase 1	Homo sapiens	89-92
35018940-0	2022	Structure-affinity relationships of reversible proline analog inhibitors targeting proline dehydrogenase.	Proline	47-54	proline dehydrogenase 1	Homo sapiens	83-104
35160087-11	2022	Circulating irisin positively correlated with both PRO-C3 and PRO-C6 levels (r = 0.47, p = 0.008 and r = 0.46, p = 0.002).	Proline	51-54	fibronectin type III domain containing 5	Homo sapiens	12-18
35018940-1	2022	Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent oxidation of L-proline to Delta1-pyrroline-5-carboxylate.	Proline	58-65	proline dehydrogenase 1	Homo sapiens	0-21
35018940-1	2022	Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent oxidation of L-proline to Delta1-pyrroline-5-carboxylate.	Proline	58-65	proline dehydrogenase 1	Homo sapiens	23-28
35018940-1	2022	Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent oxidation of L-proline to Delta1-pyrroline-5-carboxylate.	Proline	109-118	proline dehydrogenase 1	Homo sapiens	0-21
35018940-1	2022	Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent oxidation of L-proline to Delta1-pyrroline-5-carboxylate.	Proline	109-118	proline dehydrogenase 1	Homo sapiens	23-28
35018940-3	2022	Here, we studied the inhibition of PRODH by 18 proline-like compounds to understand the structural and chemical features responsible for the affinity of the best-known inhibitor, S-(-)-tetrahydro-2-furoic acid (1).	Proline	47-54	proline dehydrogenase 1	Homo sapiens	35-40
34881782-2	2022	As an intracellular target of immunosuppressive drug cyclosporin A (CsA) or a peptidyl-prolyl cis/trans isomerase (PPIase), it catalyzes the cis-trans isomerization of proline amidic peptide bonds, through which, it regulates a variety of biological processes, such as intracellular signaling, transcription, and apoptosis.	Proline	168-175	peptidylprolyl isomerase like 1	Homo sapiens	78-113
35076015-0	2022	Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH.	Proline	7-14	vasodilator stimulated phosphoprotein	Homo sapiens	83-87
35076015-0	2022	Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH.	Proline	7-14	ENAH actin regulator	Homo sapiens	96-100
35076015-4	2022	A pocket on the ENAH EVH1 domain that has diverged from other Ena/VASP paralogs recognizes extended SLiMs and favors motif-flanking proline residues.	Proline	132-139	ENAH actin regulator	Homo sapiens	16-20
35076015-4	2022	A pocket on the ENAH EVH1 domain that has diverged from other Ena/VASP paralogs recognizes extended SLiMs and favors motif-flanking proline residues.	Proline	132-139	vasodilator stimulated phosphoprotein	Homo sapiens	66-70
35076015-5	2022	Many high-affinity ENAH binders that contain two proline-rich SLiMs use a noncanonical site on the EVH1 domain for binding and display a thermodynamic signature consistent with the two-motif chain engaging a single domain.	Proline	49-56	ENAH actin regulator	Homo sapiens	19-23
35163207-1	2022	The eukaryotic translation initiation factor 5A (eIF5A) is an evolutionarily conserved protein that binds ribosomes to facilitate the translation of peptide motifs with consecutive prolines or combinations of prolines with glycine and charged amino acids.	Proline	209-217	eukaryotic translation initiation factor 5A	Homo sapiens	4-47
35163207-1	2022	The eukaryotic translation initiation factor 5A (eIF5A) is an evolutionarily conserved protein that binds ribosomes to facilitate the translation of peptide motifs with consecutive prolines or combinations of prolines with glycine and charged amino acids.	Proline	209-217	eukaryotic translation initiation factor 5A	Homo sapiens	49-54
35064112-11	2022	Following its binding to m6A, NKAP recruited the splicing factor proline and glutamine-rich (SFPQ) to recognize the splice site and then conducted transcription termination site (TTS) splicing event on SLC7A11 transcript and the retention of the last exon, screened by RNA-sequence and Mass Spectrometry (MS).	Proline	65-72	NFKB activating protein	Homo sapiens	30-34
35064112-11	2022	Following its binding to m6A, NKAP recruited the splicing factor proline and glutamine-rich (SFPQ) to recognize the splice site and then conducted transcription termination site (TTS) splicing event on SLC7A11 transcript and the retention of the last exon, screened by RNA-sequence and Mass Spectrometry (MS).	Proline	65-72	solute carrier family 7 member 11	Homo sapiens	202-209
35081133-3	2022	We show that aminopeptidase P (APP1), a metalloprotease involved in the catabolism of peptides containing proline residues near their N-terminus, prevents replication-associated genome instability.	Proline	106-113	X-prolyl aminopeptidase 1	Homo sapiens	31-35
35140727-6	2021	On a medium with high salinity, the nlp7 experienced less stress, accumulating less proline, producing less nitric oxide (NO) and reactive oxygen species (ROS), and expressing lower transcript levels of marker genes, such as RD29A and COR47, than Col-0.	Proline	84-91	NIN like protein 7	Arabidopsis thaliana	36-40
35053615-7	2022	CD26/dipeptidyl peptidase 4 (DPP4) functions as a serine protease, selectively cleaving polypeptides with a proline or alanine at the penultimate N-terminal position, such as chemokines.	Proline	108-115	dipeptidyl peptidase 4	Homo sapiens	0-27
35053615-7	2022	CD26/dipeptidyl peptidase 4 (DPP4) functions as a serine protease, selectively cleaving polypeptides with a proline or alanine at the penultimate N-terminal position, such as chemokines.	Proline	108-115	dipeptidyl peptidase 4	Homo sapiens	29-33
35053615-7	2022	CD26/dipeptidyl peptidase 4 (DPP4) functions as a serine protease, selectively cleaving polypeptides with a proline or alanine at the penultimate N-terminal position, such as chemokines.	Proline	108-115	coagulation factor II, thrombin	Homo sapiens	50-65
35082828-9	2021	These trends are discussed in the context of proline-rich motifs of SF3b4, functional and drug binding sites of SF3b1.	Proline	45-52	splicing factor 3b subunit 4	Homo sapiens	68-73
35007692-2	2022	An early conformation of full-length Tau, involving the bending of the amino terminus over the third repeated domain, is recognized by the Alz-50 antibody, followed by a second conformation recognized by Tau-66 antibody that depends on the folding of the proline-rich region over the third repeated domain in a molecule partially truncated at the amino- and carboxyl-termini.	Proline	255-262	microtubule associated protein tau	Homo sapiens	37-40
34740719-7	2022	A mutation in RdRp of SARS-CoV-2, particularly the change of Pro-to Leu-at 323 resulted in the stabilization of the structure in BRA/CD1739-P4/2020.	Proline	61-65	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	14-18
35154461-13	2022	SS-PEI/proline-modified short hairpin-(psh)RNA-ACLY plus sorafenib inhibited the growth of drug-resistant cells significantly.	Proline	7-14	ATP citrate lyase	Homo sapiens	47-51
34460901-0	2022	The dual-targeted prolyl aminopeptidase PAP1 is involved in proline accumulation in response to stress and during pollen development.	Proline	60-67	lipin 1	Homo sapiens	40-44
34460901-7	2022	Investigations into the physiological role of PAP1 using loss-of-function mutants revealed that PAP1 activity may be involved in proline homeostasis and accumulation, required for pollen development and tolerance to osmotic stress.	Proline	129-136	lipin 1	Homo sapiens	46-50
34460901-7	2022	Investigations into the physiological role of PAP1 using loss-of-function mutants revealed that PAP1 activity may be involved in proline homeostasis and accumulation, required for pollen development and tolerance to osmotic stress.	Proline	129-136	lipin 1	Homo sapiens	96-100
34460901-8	2022	Enzymatic activity, sub-cellular location, and expression patterns of PAP1 suggest a role in the chloroplastic peptide processing pathway and proline homeostasis.	Proline	142-149	lipin 1	Homo sapiens	70-74
34983843-7	2022	Adding a proline residue to the C terminus of the ctVSD and R95M substitution of VSR1 disrupted receptor-cargo interactions in vitro and led to increased secretion of spRFP in Arabidopsis protoplasts.	Proline	9-16	vacuolar sorting receptor homolog 1	Arabidopsis thaliana	81-85
35466299-9	2022	Results: A statistically significant (P < 0.001) moderate negative correlation (r = -0.500) was found between salivary statherin and proline-rich protein levels.	Proline	133-140	statherin	Homo sapiens	119-128
35181621-3	2022	Proline-rich 11 (PRR11) is an emerging oncogene in cancers, while its effect in CRC remains unclear.	Proline	0-7	proline rich 11	Homo sapiens	17-22
34974814-0	2022	Prostate-specific membrane antigen modulates the progression of prostate cancer by regulating the synthesis of arginine and proline and the expression of androgen receptors and Fos proto-oncogenes.	Proline	124-131	folate hydrolase 1	Homo sapiens	0-34
34974814-8	2022	The depletion of PSMA also promoted the biosynthesis of arginine and proline, inhibited the expression of AR and PSA, and induced the expression of c-Fos and FosB.	Proline	69-76	folate hydrolase 1	Homo sapiens	17-21
35005120-7	2022	Notably, PRR11 mutant deletion of the proline-rich region 2 (amino acid residues 185-200) abrogated the effect of filopodia formation.	Proline	38-45	proline rich 11	Homo sapiens	9-14
35072516-6	2022	The role of a gene variant in Tp53 that modifies proline to arginine was examined using nasal brushings from study participants in the Lovelace Smokers Cohort, primary human AECs, and mice with a modified Tp53 gene.	Proline	49-56	tumor protein p53	Homo sapiens	30-34
35072516-8	2022	Study participants who were homozygous for p53 arginine compared with the proline variant showed higher mucin 5AC (MUC5AC) mRNA levels in nasal brushings if they reported WS exposure.	Proline	74-81	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	104-113
35072516-8	2022	Study participants who were homozygous for p53 arginine compared with the proline variant showed higher mucin 5AC (MUC5AC) mRNA levels in nasal brushings if they reported WS exposure.	Proline	74-81	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	115-121
35167412-8	2022	We demonstrated in cells and with purified mCherry protein that the fluorescence of mCherry Ser151Pro is rescued by two different tRNASer gene variants that were mutated to contain the Pro (UGG) anticodon.	Proline	185-188	tRNA-Ser (anticodon AGA) 2-3	Homo sapiens	130-137