PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
10997936-6	2000	Bupropion hydroxylation activity at 250 microM was highly correlated with S-mephenytoin N-demethylation activity (yielding nirvanol), another CYP2B6-mediated reaction, in a panel of 32 human livers (r = 0.94).	ethylphenylhydantoin	123-131	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	142-148
12844133-8	2003	The area under the concentration-time curve ratio of S-nirvanol/S-mephenytoin, an index of CYP2B6 activity, increased 1.9-fold (P <.05) in CYP2C19 poor metabolizers during artemisinin multiple-dose administration, whereas the urinary excretion ratio of hydroxytolbutamide plus carboxytolbutamide/tolbutamide remained constant during the study period.	ethylphenylhydantoin	53-63	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	91-97
12844133-8	2003	The area under the concentration-time curve ratio of S-nirvanol/S-mephenytoin, an index of CYP2B6 activity, increased 1.9-fold (P <.05) in CYP2C19 poor metabolizers during artemisinin multiple-dose administration, whereas the urinary excretion ratio of hydroxytolbutamide plus carboxytolbutamide/tolbutamide remained constant during the study period.	ethylphenylhydantoin	53-63	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	142-149
11950782-7	2002	Enzyme activity was reduced 78.1 +/- 0.2% by 50 microM thioTEPA when CYP2B6 activity was measured by following the metabolism of 200 microM S-mephenytoin to nirvanol.	ethylphenylhydantoin	157-165	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	69-75
11854139-2	2002	In the present study, N-3-benzyl derivatives of nirvanol and phenobarbital were synthesized, their respective (+)- and (-)-enantiomers resolved chromatographically, and inhibitor potencies determined for these compounds toward CYP2C19 and other human liver cytochromes P450 (P450s).	ethylphenylhydantoin	48-56	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	227-234
11854139-2	2002	In the present study, N-3-benzyl derivatives of nirvanol and phenobarbital were synthesized, their respective (+)- and (-)-enantiomers resolved chromatographically, and inhibitor potencies determined for these compounds toward CYP2C19 and other human liver cytochromes P450 (P450s).	ethylphenylhydantoin	48-56	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	269-273
1417986-4	1992	PB and two structural analogues (ethylphenylhydantoin and barbital) induced a variety of drug-metabolizing enzymes (CYP2B, CYP3A, CYP2A, epoxide hydrolase) in a series of inbred strains of rats.	ethylphenylhydantoin	33-53	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	123-128
9732386-5	1998	CYP2B6 levels were found to significantly (P < .0001) correlate with S-mephenytoin N-demethylation to nirvanol (r2 = 0.89), 7-hydroxy-4-trifluoromethylcoumarin formation (r2 = 0.81) and several markers of CYP3A levels and activity.	ethylphenylhydantoin	105-113	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-6
9732386-6	1998	The relationships between nirvanol formation and CYP3A levels or activity were found to depend on two HLM samples.	ethylphenylhydantoin	26-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-54
9732386-10	1998	In conclusion, the highly specific MAb 49-10-20 was used to provide further confirmation that S-mephenytoin N-demethylation to nirvanol is a CYP2B6 selective probe.	ethylphenylhydantoin	127-135	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	141-147
9698292-1	1998	We tested the ability of human liver microsomes (HLMs) and recombinant human cytochrome P450 (CYP or P450) isoforms to catalyze the N-demethylation of nirvanol-free (S)-mephenytoin [(S)-MP] in vitro.	ethylphenylhydantoin	151-159	peptidylprolyl isomerase G	Homo sapiens	94-97
9698292-5	1998	Of the recombinant P450 isoforms tested, only CYP2B6 and CYP2C9 formed nirvanol from (S)-MP.	ethylphenylhydantoin	71-79	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	46-52
9698292-5	1998	Of the recombinant P450 isoforms tested, only CYP2B6 and CYP2C9 formed nirvanol from (S)-MP.	ethylphenylhydantoin	71-79	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	57-63
9698292-9	1998	Therefore, the N-demethylation of (S)-MP to nirvanol may be a useful means of probing the activity of CYP2B6 in vitro when concentrations of >1000 microM are used, but it is unlikely to be a suitable phenotyping tool for this isoform in vivo, where concentrations of >1000 microM are rarely encountered.	ethylphenylhydantoin	44-52	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	102-108
1554380-2	1992	Thus, following administration of PB (300, 500 ppm), barbital (BB, 1500 ppm) or 5-ethyl-5-phenylhydantoin (EPH, 500 ppm), CYP2B1-mediated benzyloxyresorufin O-dealkylase activity and epoxide hydrolase activity were profoundly induced in female DA and F344/NCr rats.	ethylphenylhydantoin	80-105	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	122-128
18071681-4	2008	We also assessed whether urinary excretion of N-desmethylmephenytoin (nirvanol) might be a useful CYP2B6 metric in in vivo studies.	ethylphenylhydantoin	70-78	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	98-104
18071681-11	2008	While nirvanol excretion may reflect CYP2B6 activity in vivo, it is not useful for CYP2B6 phenotyping.	ethylphenylhydantoin	6-14	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	37-43