PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29123986-4	2017	To clarify the regulation of progalanin via plasminogen activation by urokinase and tissue-plasminogen activator (t-PA), we investigated the regulation mechanism for urokinase and t-PA expression and their effect on galanin activation.	progalanin	29-39	plasminogen activator, tissue	Mus musculus	114-118
21707521-0	2011	Plasmin: its role in the extracellular processing of progalanin in tumor tissue.	progalanin	53-63	plasminogen	Homo sapiens	0-7
23261456-0	2013	Involvement of plasmin-mediated extracellular activation of progalanin in angiogenesis.	progalanin	60-70	plasminogen	Homo sapiens	15-22
23261456-1	2013	Progalanin is released from the small cell lung carcinoma line SBC-3A and converted to its active form by plasmin.	progalanin	0-10	plasminogen	Homo sapiens	106-113
23261456-4	2013	MMP activity and angiogenesis were reduced in tumors induced by transplantation of progalanin siRNA-treated SBC-3A cells.	progalanin	83-93	matrix metallopeptidase 2	Homo sapiens	0-3
23261456-5	2013	In contrast, MMP-9 and MMP-2 activity and angiogenesis increased in tumors originating from progalanin siRNA-treated SBC-3A cells in the presence of galanin and progalanin.	progalanin	92-102	matrix metallopeptidase 9	Homo sapiens	13-18
23261456-5	2013	In contrast, MMP-9 and MMP-2 activity and angiogenesis increased in tumors originating from progalanin siRNA-treated SBC-3A cells in the presence of galanin and progalanin.	progalanin	92-102	matrix metallopeptidase 2	Homo sapiens	23-28
23261456-9	2013	These results suggest that the activation of progalanin by plasmin in the extracellular compartment was involved in MMP-9 and MMP-2 activation and in angiogenesis in tumor tissue.	progalanin	45-55	plasminogen	Homo sapiens	59-66
23261456-9	2013	These results suggest that the activation of progalanin by plasmin in the extracellular compartment was involved in MMP-9 and MMP-2 activation and in angiogenesis in tumor tissue.	progalanin	45-55	matrix metallopeptidase 9	Homo sapiens	116-121
23261456-9	2013	These results suggest that the activation of progalanin by plasmin in the extracellular compartment was involved in MMP-9 and MMP-2 activation and in angiogenesis in tumor tissue.	progalanin	45-55	matrix metallopeptidase 2	Homo sapiens	126-131
21707521-4	2011	The present study was performed to identify the trypsin-like protease which had previously been found to activate progalanin in this tumor tissue.	progalanin	114-124	kallikrein related peptidase 11	Homo sapiens	48-69
21707521-10	2011	In addition, tranexamic acid, a plasmin inhibitor, inhibited progalanin conversion to galanin(1-20).	progalanin	61-71	plasminogen	Homo sapiens	32-39
21707521-11	2011	The present study revealed that plasmin was present in tumor tissue, and that it was responsible for processing progalanin to galanin(1-20) in the extracellular environment.	progalanin	112-122	plasminogen	Homo sapiens	32-39
21605060-7	2011	We then looked at MMP-2 and MMP-9 release from SBC-3A cells and tumor tissue treated with galanin and progalanin, as revealed by gelatin zymography.	progalanin	102-112	matrix metallopeptidase 9	Homo sapiens	28-33
21605060-8	2011	Galanin elicited pro-MMP-2 and pro-MMP-9 release from SBC-3A cells and tumor tissue; however, recombinant progalanin induced pro-MMP-2 and pro-MMP-9 release from tumor tissue only.	progalanin	106-116	matrix metallopeptidase 2	Homo sapiens	129-134
21605060-8	2011	Galanin elicited pro-MMP-2 and pro-MMP-9 release from SBC-3A cells and tumor tissue; however, recombinant progalanin induced pro-MMP-2 and pro-MMP-9 release from tumor tissue only.	progalanin	106-116	matrix metallopeptidase 9	Homo sapiens	143-148