PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 19210406-4 1989 By comparison of the effect of the excitatory amino-acid agonists N-methyl-D-aspartate (NMDA), quisqualate and kainate on the release of alpha-MSH from superfused slices of rat hypothalamus, we have demonstrated a stimulatory glutamergic action on alpha-MSH release mediated through NMDA-type receptors. Excitatory Amino Acids 35-56 proopiomelanocortin Rattus norvegicus 137-146 2570182-0 1989 A grease-gap method for studying the excitatory amino acid pharmacology of CA1 hippocampal pyramidal cells. Excitatory Amino Acids 37-58 carbonic anhydrase 1 Rattus norvegicus 75-78 2802217-2 1989 Actions of the agents on excitatory amino acid-mediated neurotransmission were studied by observing evoked responses and long-term potentiation in the stratum pyramidale of CA1 with stimulation of the contralateral CA3 region. Excitatory Amino Acids 25-46 carbonic anhydrase 1 Rattus norvegicus 173-176 2696980-2 1989 Evidence has been presented that the SI/LPO contains glutamatergic nerve terminals and receptors for excitatory amino acids. Excitatory Amino Acids 101-123 lactoperoxidase Homo sapiens 37-43 2696980-3 1989 The purpose of this study was to determine the effects of the activation of excitatory amino acid receptors in the SI/LPO on locomotor activity following the direct injection of excitatory amino acids into this brain site. Excitatory Amino Acids 178-200 lactoperoxidase Homo sapiens 118-121 2900050-0 1988 The response of striatal neuropeptide Y and cholinergic neurons to excitatory amino acid agonists. Excitatory Amino Acids 67-88 neuropeptide Y Rattus norvegicus 25-39 2473826-6 1989 The possible identity of the transmitter operating in the LHb-NRD pathway was investigated by NRD injections of kynurenic acid, a potent blocker of excitatory amino acid transmission, and by NRD injections of the GABA antagonist bicuculline. Excitatory Amino Acids 148-169 luteinizing hormone subunit beta Rattus norvegicus 58-61 2473826-10 1989 These data are compatible with the idea that excitatory amino acids in the LHb-NRD pathway are involved in the regulation of striatal 5-HT release, and that this influence is modulated by GABAergic synaptic activity at the level of the NRD. Excitatory Amino Acids 45-67 luteinizing hormone subunit beta Rattus norvegicus 75-78 2570704-5 1989 This study suggests that excitatory amino acids may participate in the methamphetamine-induced decline in central TPH activity, and that the mechanism by which MDMA and methamphetamine decreases TPH activity may differ. Excitatory Amino Acids 25-47 tryptophan hydroxylase 1 Rattus norvegicus 114-117 3219473-2 1988 A quantitative pharmacological investigation of the actions of excitatory amino acids on hippocampal CA1 neurones has been made using a new slice preparation developed for grease gap recording; d.c. potential was measured across a grease barrier placed between alvear fibres and the bathing medium. Excitatory Amino Acids 63-85 carbonic anhydrase 1 Rattus norvegicus 101-104 2542463-2 1989 We have examined whether the binding of [3H]NAAG and stimulation of phosphoinositide hydrolysis by IBO are indexing the same or different populations of AP4-sensitive excitatory amino acid sites in brain. Excitatory Amino Acids 167-188 replication initiator 1 Rattus norvegicus 153-156 2542482-8 1989 The present results suggest that an important component of the neurotransmission of bulbospinal respiratory drive involves endogenous excitatory amino acids acting at AP4-sensitive sites and other non-NMDA (quisqualate/kainate) receptors. Excitatory Amino Acids 134-156 replication initiator 1 Rattus norvegicus 167-170 2566354-0 1989 6-Cyano-7-nitroquinoxaline-2,3-dione as an excitatory amino acid antagonist in area CA1 of rat hippocampus. Excitatory Amino Acids 43-64 carbonic anhydrase 1 Rattus norvegicus 84-87 2566354-2 1989 A quantitative pharmacological investigation of the excitatory amino acid antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) has been made in area CA1 of rat hippocampal slices bathed in 1 mM Mg2+ containing medium. Excitatory Amino Acids 52-73 carbonic anhydrase 1 Rattus norvegicus 151-154 2467978-2 1989 We have found that muscimol, a GABAA receptor agonist, but not baclofen, a GABAB receptor agonist, dose-dependently inhibited caudally directed biting and scratching behavior induced by all three EAA agonists. Excitatory Amino Acids 196-199 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 31-36 2900050-1 1988 The effect of excitatory amino acid antagonists on antagonist on neuropeptide Y (NPY) and cholinergic neurons in the striatum of the rat was studied by means of NPY immunocytochemistry, DFP histochemistry for acetylcholinesterase (AChE), and biochemical determinations of choline acetyltransferase (ChAT). Excitatory Amino Acids 14-35 neuropeptide Y Rattus norvegicus 65-79 2900050-1 1988 The effect of excitatory amino acid antagonists on antagonist on neuropeptide Y (NPY) and cholinergic neurons in the striatum of the rat was studied by means of NPY immunocytochemistry, DFP histochemistry for acetylcholinesterase (AChE), and biochemical determinations of choline acetyltransferase (ChAT). Excitatory Amino Acids 14-35 neuropeptide Y Rattus norvegicus 81-84 2900050-1 1988 The effect of excitatory amino acid antagonists on antagonist on neuropeptide Y (NPY) and cholinergic neurons in the striatum of the rat was studied by means of NPY immunocytochemistry, DFP histochemistry for acetylcholinesterase (AChE), and biochemical determinations of choline acetyltransferase (ChAT). Excitatory Amino Acids 14-35 acetylcholinesterase Rattus norvegicus 231-235 2900050-1 1988 The effect of excitatory amino acid antagonists on antagonist on neuropeptide Y (NPY) and cholinergic neurons in the striatum of the rat was studied by means of NPY immunocytochemistry, DFP histochemistry for acetylcholinesterase (AChE), and biochemical determinations of choline acetyltransferase (ChAT). Excitatory Amino Acids 14-35 choline O-acetyltransferase Rattus norvegicus 272-297 2452481-0 1988 Sustained dendritic gradients of Ca2+ induced by excitatory amino acids in CA1 hippocampal neurons. Excitatory Amino Acids 49-71 carbonic anhydrase 2 Homo sapiens 33-36 2452481-0 1988 Sustained dendritic gradients of Ca2+ induced by excitatory amino acids in CA1 hippocampal neurons. Excitatory Amino Acids 49-71 carbonic anhydrase 1 Homo sapiens 75-78 3282616-0 1988 Developmental changes in neuronal sensitivity to excitatory amino acids in area CA1 of the rat hippocampus. Excitatory Amino Acids 49-71 carbonic anhydrase 1 Rattus norvegicus 80-83 2895802-7 1988 These data suggest that Rohon-Beard neurons release an excitatory amino acid neurotransmitter, which acts simultaneously at both N-methyl-D-aspartate (NMDA) and non-NMDA receptor types. Excitatory Amino Acids 55-76 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 165-178 3309706-6 1987 Therefore, just as the adenohypophysis can be driven by exogenous LHRH to initiate puberty, the LHRH neuronal system can be precociously activated by the episodic administration of an excitatory amino acid analog that is known to interact with specific brain receptors. Excitatory Amino Acids 184-205 gonadotropin releasing hormone 1 Rattus norvegicus 96-100 2449626-3 1987 Among the other excitatory amino acid agonists N-methyl-D-Aspartate (NMDA) and quisqualate also increased c-fos mRNA content, the latter however to a significantly lesser extent, while kainate failed to modify the basal level of c-fos expression. Excitatory Amino Acids 16-37 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 106-111 3323951-1 1987 We examined the influence of helium pressure on the depression induced by various excitatory amino acids in CA1 hippocampal field potentials. Excitatory Amino Acids 82-104 carbonic anhydrase 1 Rattus norvegicus 108-111 2893317-1 1987 The relationship between the long-lasting enhancement of synaptic transmission produced by a phorbol ester and the release of endogenous excitatory amino acids has been investigated in the CA1 hippocampal region of the anaesthetized rat. Excitatory Amino Acids 137-159 carbonic anhydrase 1 Rattus norvegicus 189-192 3295120-1 1987 Pretreatment of rats with the excitatory amino acid antagonist 2-amino-7-phosphonoheptanoic acid (2-APH; 0.5 mmol/kg, i.p.) Excitatory Amino Acids 30-51 acylaminoacyl-peptide hydrolase Rattus norvegicus 100-103 2887261-1 1987 Sensitivity of cyclic GMP synthesis to stimulation by excitatory amino acids, depolarizing agents, and divalent cation ionophores develops during the differentiation of cerebellar neurons in culture; in each case calcium influx appears responsible for activating guanylate cyclase. Excitatory Amino Acids 54-76 5'-nucleotidase, cytosolic II Homo sapiens 22-25 2879893-2 1987 This increase is reversed by low concentrations of 2-amino-5-phosphono-valerate (APV), a result indicating that the absence of Mg2+ facilitates the activation of a specific receptor by the endogenous excitatory amino acids (presumably L-glutamate and L-aspartate) released from the granule cells. Excitatory Amino Acids 200-222 mucin 7, secreted Homo sapiens 127-130 2888931-3 1987 Focal injection of an excitatory amino acid antagonist acting competitively on the N-methyl-D-aspartate (NMDA) receptor, 2-amino-7-phosphonoheptanoic acid (2-APH) in one hippocampus protects against the early cytopathology, and, when repeated 4 and 10 hours after the ischaemia, partially protects against selective nerve cell loss. Excitatory Amino Acids 22-43 acylaminoacyl-peptide hydrolase Rattus norvegicus 158-161 2882447-0 1987 Excitatory amino acids increase glycogen phosphorylase activity in the rat spinal cord. Excitatory Amino Acids 0-22 glycogen phosphorylase L Rattus norvegicus 32-54 20493057-7 1986 It is proposed (i) that changes in the level and turnover of excitatory amino acid transmitters in AGS rats occur as a consequence of a primary biochemical defect that probably involves impaired neuronal membrane transport, and (ii) that altered function in excitatory synapses in the inferior colliculus, substantia nigra and reticular formation contributes importantly to the seizure susceptibility. Excitatory Amino Acids 61-82 milk fat globule EGF and factor V/VIII domain containing Rattus norvegicus 99-102 3022192-1 1986 Receptors preferentially activated by the excitatory amino acid N-methyl-D-aspartate (NMDA) do not mediate synaptic transmission in the hippocampus but are involved in initiating long-term potentiation (LTP) in hippocampal region CA1. Excitatory Amino Acids 42-63 carbonic anhydrase 1 Cavia porcellus 230-233 3727181-2 1986 2-Amino-7-phosphonoheptanoic acid (2-APH) is a novel antagonist of excitatory amino acids with preferential activity at the N-methyl-D-aspartate receptor. Excitatory Amino Acids 67-89 acylaminoacyl-peptide hydrolase Rattus norvegicus 37-40 2878570-0 1986 Blockade by D-aminophosphonovalerate or Mg2+ of excitatory amino acid-induced responses on spinal motoneurons in vitro. Excitatory Amino Acids 48-69 mucin 7, secreted Homo sapiens 40-43 2434059-3 1986 DDT also increases levels of excitatory amino acids glutamate (GLU) and aspartate (ASP), but the effect occurs only in the brain stem. Excitatory Amino Acids 29-51 D-dopachrome tautomerase Rattus norvegicus 0-3 2430673-5 1986 Decreases in [Ca2+]o induced either by repetitive stimulation or by application of the excitatory amino acids N-methyl-D-aspartate and quisqualate were reduced, and the latter results suggest that VPA interferes with postsynaptic Ca2+ entry. Excitatory Amino Acids 87-109 carbonic anhydrase 2 Rattus norvegicus 14-17 2422596-4 1986 Both glutaminase, an enzyme which converts glutamine to glutamate, and aspartate aminotransferase, an enzyme which is involved in the interconversion between glutamate and aspartate, have been proposed to be markers of neurons which use excitatory amino acids as neurotransmitters. Excitatory Amino Acids 237-259 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 71-97 4045547-11 1985 When combined with the findings of other studies, our results suggest that GLNase IR marks pyramidal neurons that use an excitatory amino acid transmitter. Excitatory Amino Acids 121-142 glutaminase Rattus norvegicus 75-81 4045547-13 1985 The AATase immunoreactivity of these cells could indicate that they use an excitatory amino acid transmitter. Excitatory Amino Acids 75-96 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 4-10 2864107-8 1985 It was concluded that under these experimental conditions the effect of AVP on excitatory amino acid neurotransmission is more pronounced than on responses to putative monoaminergic neurotransmitters in the lateral septum. Excitatory Amino Acids 79-100 arginine vasopressin Rattus norvegicus 72-75 3886076-2 1985 We have attempted to immunocytochemically identify excitatory amino acid neurons in the hippocampus of the rat and guinea pig using antiserum to glutaminase and antiserum to aspartate aminotransferase, which have been proposed as markers for aspartergic/glutamergic neurons. Excitatory Amino Acids 51-72 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 174-200 2990528-1 1985 The binding of the excitatory amino acid antagonist DL-2-amino-4-phosphonobutanoic acid (DL-APB) to rat brain synaptic plasma membranes was characterized. Excitatory Amino Acids 19-40 arginyl aminopeptidase Rattus norvegicus 92-95 6089047-1 1984 Reductions in extracellular free Ca2+-concentration [( Ca2+]o) result from neuronal activation and can be induced by repetitive electrical stimulation or by application of excitatory amino acids. Excitatory Amino Acids 172-194 carbonic anhydrase 2 Rattus norvegicus 33-36 6499918-7 1984 Pretreatment with the excitatory amino acid antagonist, 2-amino-7-phosphonoheptanoic acid (2-APH), 110 mg/kg i.v., prevents the generalised seizures induced by DMCM, 0.5 mg/kg, but not those induced by beta-CCM, 0.1-0.2 mg/kg. Excitatory Amino Acids 22-43 acylpeptide hydrolase Mus musculus 93-96 6149788-0 1984 Arginine-vasopressin enhances the responses of lateral septal neurons in the rat to excitatory amino acids and fimbria-fornix stimuli. Excitatory Amino Acids 84-106 arginine vasopressin Rattus norvegicus 0-20 6089047-1 1984 Reductions in extracellular free Ca2+-concentration [( Ca2+]o) result from neuronal activation and can be induced by repetitive electrical stimulation or by application of excitatory amino acids. Excitatory Amino Acids 172-194 carbonic anhydrase 2 Rattus norvegicus 55-58 6134568-2 1983 By means of this technique, we found that antagonists of excitatory amino acids, cis-2,3-piperidine dicarboxylic acid, gamma-D-glutamylglycine and glutamic acid diethylester, blocked excitation induced in CA3 neurons by glutamate and by mossy fiber stimulation in thin hippocampal sections of the guinea pig. Excitatory Amino Acids 57-79 carbonic anhydrase 3 Cavia porcellus 205-208 6664465-0 1983 Relative potency of analogues of excitatory amino acids on hippocampal CA1 neurons. Excitatory Amino Acids 33-55 carbonic anhydrase 1 Homo sapiens 71-74 6664465-1 1983 The relative potency of analogues of excitatory amino acids to produce depolarization when applied in the apical dendritic field of CA1 cells was studied in the hippocampal slice. Excitatory Amino Acids 37-59 carbonic anhydrase 1 Homo sapiens 132-135 6134823-2 1983 The effects of the ionophoretic application of a number of excitatory amino acids and antagonists to the dendrites of CA1 neurones of rat hippocampal slices maintained in vitro were examined. Excitatory Amino Acids 59-81 carbonic anhydrase 1 Rattus norvegicus 118-121 6133238-1 1980 D- and L-5-aminohex-2-enedioic acid (AHED) and the DL-2-bromo derivative, which are conformationally restricted analogues of the excitatory amino acid antagonist D-alpha-aminoadipic acid (D alpha AA), were tested microelectrophoretically on cat spinal neurones. Excitatory Amino Acids 129-150 ribosomal protein L5 Homo sapiens 7-10 6294543-10 1982 The (-) isomer of cis-2,3-PDA carried both excitatory amino acid agonist and antagonist activity and also the synaptic depressant properties observed with the racemic form of this substance. Excitatory Amino Acids 43-64 suppressor of cytokine signaling 2 Homo sapiens 18-23 6255763-0 1981 Excitatory amino acid-induced changes in cyclic GMP levels in slices and cell suspensions from the cerebellum. Excitatory Amino Acids 0-21 5'-nucleotidase, cytosolic II Homo sapiens 48-51 6266222-0 1981 Receptors for excitatory amino acids: binding studies and stimulation of cyclic GMP levels. Excitatory Amino Acids 14-36 5'-nucleotidase, cytosolic II Homo sapiens 80-83 32195595-8 2020 After adrenalectomy, mice receiving EAA had less NE, FNDC5, irisin and UCP-1 as well as greater expression of inflammatory cytokines and bodyweight. Excitatory Amino Acids 36-39 fibronectin type III domain containing 5 Mus musculus 53-58 33608833-9 2022 The head circumference, MDI, and PDI in EAA group at 20 months of correct age were significantly higher than that in SAA group (both P < 0.05). Excitatory Amino Acids 40-43 peptidyl arginine deiminase 1 Homo sapiens 33-36 32827867-5 2020 We have recently shown that two transporters are critical for the anaplerotic use of glutamate: the Na+-dependent Excitatory Amino Acids Carrier 1 (EAAC1) and the Na+-Ca2+ exchanger 1 (NCX1). Excitatory Amino Acids 114-136 solute carrier family 1 member 1 Homo sapiens 148-153 32827867-5 2020 We have recently shown that two transporters are critical for the anaplerotic use of glutamate: the Na+-dependent Excitatory Amino Acids Carrier 1 (EAAC1) and the Na+-Ca2+ exchanger 1 (NCX1). Excitatory Amino Acids 114-136 solute carrier family 8 member A1 Homo sapiens 163-183 32195595-8 2020 After adrenalectomy, mice receiving EAA had less NE, FNDC5, irisin and UCP-1 as well as greater expression of inflammatory cytokines and bodyweight. Excitatory Amino Acids 36-39 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 71-76 32724636-8 2020 We also found that LPS stimulated the mouse macrophage cell line, Raw264.7, and secreted a tremendous level of proinflammatory cytokines and the secretion of these cytokines was reduced with EAA treatment via downregulation of mitogen-activated protein kinase phosphorylation and p65 translocation. Excitatory Amino Acids 191-194 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 280-283 30969437-4 2019 Recent studies have implicated glutamatergic targets of FMRP in hereditary cerebellar ataxias including the main cerebellar excitatory amino acid (Eaa1) transporter and a subtype of metabotropic glutamate receptor (Grm5). Excitatory Amino Acids 124-145 fragile X messenger ribonucleoprotein 1 Rattus norvegicus 56-60 28386239-7 2017 Independent of exercise mode, miR-1-3p and miR-208a-5p expression were lower (P < 0.05) after ingesting EAA+CHO compared to CON. Excitatory Amino Acids 107-110 membrane associated ring-CH-type finger 8 Homo sapiens 30-33 28875233-6 2018 Once internalized, this excitatory amino acid is rapidly metabolized to glutamine via the astrocyte-enriched enzyme glutamine synthetase. Excitatory Amino Acids 24-45 glutamate-ammonia ligase Homo sapiens 116-136 28955770-2 2017 In particular, addicsin acts as a negative modulator of neural glutamate transporter excitatory amino acid carrier 1 (EAAC1) and participates in the regulation of intracellular glutathione (GSH) content by negatively modulating EAAC1-mediated cysteine and glutamate uptake. Excitatory Amino Acids 85-106 ADP-ribosylation factor-like 6 interacting protein 5 Mus musculus 15-23 28955770-2 2017 In particular, addicsin acts as a negative modulator of neural glutamate transporter excitatory amino acid carrier 1 (EAAC1) and participates in the regulation of intracellular glutathione (GSH) content by negatively modulating EAAC1-mediated cysteine and glutamate uptake. Excitatory Amino Acids 85-106 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Mus musculus 118-123 29955707-8 2017 Tumor suppressor p53 (p53), mitochondrial transcription factor A (TFAM), and cytochrome c oxidase subunit IV (COXIV) expression was greater for CON than for CHO+EAA treatments (drink main effect, P < 0.05). Excitatory Amino Acids 161-164 tumor protein p53 Homo sapiens 17-20 29955707-8 2017 Tumor suppressor p53 (p53), mitochondrial transcription factor A (TFAM), and cytochrome c oxidase subunit IV (COXIV) expression was greater for CON than for CHO+EAA treatments (drink main effect, P < 0.05). Excitatory Amino Acids 161-164 cytochrome c oxidase subunit 4I1 Homo sapiens 77-108 29955707-8 2017 Tumor suppressor p53 (p53), mitochondrial transcription factor A (TFAM), and cytochrome c oxidase subunit IV (COXIV) expression was greater for CON than for CHO+EAA treatments (drink main effect, P < 0.05). Excitatory Amino Acids 161-164 cytochrome c oxidase subunit 4I1 Homo sapiens 110-115 28386239-7 2017 Independent of exercise mode, miR-1-3p and miR-208a-5p expression were lower (P < 0.05) after ingesting EAA+CHO compared to CON. Excitatory Amino Acids 107-110 microRNA 208a Homo sapiens 43-51 27663541-3 2016 GLAST and GLT1 are expressed in glial cells, whereas excitatory amino acid transporter 3/excitatory amino acid carrier 1 (EAAT3/EAAC1) is neuronal. Excitatory Amino Acids 53-74 solute carrier family 1 member 1 Rattus norvegicus 122-127 27663541-3 2016 GLAST and GLT1 are expressed in glial cells, whereas excitatory amino acid transporter 3/excitatory amino acid carrier 1 (EAAT3/EAAC1) is neuronal. Excitatory Amino Acids 53-74 solute carrier family 1 member 1 Rattus norvegicus 128-133 27142584-4 2016 Compared with non-targeting liposomes, T7&SHp-P-LPs/ZL006 could transport across BCEC cells and significantly enhance cellular uptake and reduce cells apoptosis of excitatory amino acid stimulated PC-12 cells. Excitatory Amino Acids 168-189 nuclear receptor subfamily 0, group B, member 2 Rattus norvegicus 46-49 27211874-1 2016 Estrogen attenuates the loss of dopamine neurons from the substantia nigra in animal models of Parkinson"s disease (PD) and excitatory amino-acid induced neurotoxicity by interactions with brain-derived neurotrophic factor (BDNF), and calretinin (CR) containing dopaminergic (DA) neurons. Excitatory Amino Acids 124-145 brain derived neurotrophic factor Mus musculus 189-222 27211874-1 2016 Estrogen attenuates the loss of dopamine neurons from the substantia nigra in animal models of Parkinson"s disease (PD) and excitatory amino-acid induced neurotoxicity by interactions with brain-derived neurotrophic factor (BDNF), and calretinin (CR) containing dopaminergic (DA) neurons. Excitatory Amino Acids 124-145 brain derived neurotrophic factor Mus musculus 224-228 27211874-1 2016 Estrogen attenuates the loss of dopamine neurons from the substantia nigra in animal models of Parkinson"s disease (PD) and excitatory amino-acid induced neurotoxicity by interactions with brain-derived neurotrophic factor (BDNF), and calretinin (CR) containing dopaminergic (DA) neurons. Excitatory Amino Acids 124-145 calbindin 2 Mus musculus 235-245 27211874-1 2016 Estrogen attenuates the loss of dopamine neurons from the substantia nigra in animal models of Parkinson"s disease (PD) and excitatory amino-acid induced neurotoxicity by interactions with brain-derived neurotrophic factor (BDNF), and calretinin (CR) containing dopaminergic (DA) neurons. Excitatory Amino Acids 124-145 calbindin 2 Mus musculus 247-249 27457480-11 2016 Antisense oligodeoxynucleotides of NMDA receptor subunits NR1, NR2A, NR2B significantly enhanced the inhibition of paeoniflorin on excitatory amino acid-and high-dose morphine-induced nociception. Excitatory Amino Acids 131-152 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 58-61 27457480-11 2016 Antisense oligodeoxynucleotides of NMDA receptor subunits NR1, NR2A, NR2B significantly enhanced the inhibition of paeoniflorin on excitatory amino acid-and high-dose morphine-induced nociception. Excitatory Amino Acids 131-152 glutamate receptor, ionotropic, NMDA2A (epsilon 1) Mus musculus 63-67 27457480-11 2016 Antisense oligodeoxynucleotides of NMDA receptor subunits NR1, NR2A, NR2B significantly enhanced the inhibition of paeoniflorin on excitatory amino acid-and high-dose morphine-induced nociception. Excitatory Amino Acids 131-152 glutamate receptor, ionotropic, NMDA2B (epsilon 2) Mus musculus 69-73 27457480-13 2016 CONCLUSIONS: Results of this study indicate that paeoniflorin-induced inhibition of excitatory amino acid agonist- and high-dose morphine-induced nociceptive behaviors might be due to modulation of NMDA receptors, specifically the NR2B subunit. Excitatory Amino Acids 84-105 glutamate receptor, ionotropic, NMDA2B (epsilon 2) Mus musculus 231-235 26157044-9 2015 These results suggest that the activation of MrgC receptors can modulate the increase in the expression of CGRP and neuronal nitric oxide synthase as well as the release of CGRP and excitatory amino acids in DRG associated with inflammatory pain. Excitatory Amino Acids 182-204 MAS-related G-protein coupled receptor, member C Rattus norvegicus 45-49 27040821-1 2016 Excitatory amino acid carrier type 1 (EAAC1), a high-affinity glutamate transporter, can expend energy to move glutamate into neurons. Excitatory Amino Acids 0-21 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Mus musculus 38-43 25172945-0 2014 LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes. Excitatory Amino Acids 82-104 leucine rich repeat containing 8 VRAC subunit A Rattus norvegicus 0-6 25595600-0 2015 Immunization with DISC1 protein in an animal model of ADHD influences behavior and excitatory amino acids in prefrontal cortex and striatum. Excitatory Amino Acids 83-105 DISC1 scaffold protein Rattus norvegicus 18-23 26684854-5 2015 The present study explored the effect of Klotho protein on the excitatory glutamate transporters EAAT1 (SLC1A3) and EAAT2 (SLC1A2), Na+ coupled carriers clearing excitatory amino acids from the synaptic cleft and thus participating in the regulation of neuronal excitability. Excitatory Amino Acids 162-184 solute carrier family 1 member 3 L homeolog Xenopus laevis 97-102 26684854-5 2015 The present study explored the effect of Klotho protein on the excitatory glutamate transporters EAAT1 (SLC1A3) and EAAT2 (SLC1A2), Na+ coupled carriers clearing excitatory amino acids from the synaptic cleft and thus participating in the regulation of neuronal excitability. Excitatory Amino Acids 162-184 solute carrier family 1 member 3 L homeolog Xenopus laevis 104-110 26684854-5 2015 The present study explored the effect of Klotho protein on the excitatory glutamate transporters EAAT1 (SLC1A3) and EAAT2 (SLC1A2), Na+ coupled carriers clearing excitatory amino acids from the synaptic cleft and thus participating in the regulation of neuronal excitability. Excitatory Amino Acids 162-184 solute carrier family 1 member 2 L homeolog Xenopus laevis 116-121 26092725-3 2015 Here we report that NRG1 influences glutamate uptake by increasing the protein level of excitatory amino acid carrier (EAAC1). Excitatory Amino Acids 88-109 neuregulin 1 Mus musculus 20-24 26092725-3 2015 Here we report that NRG1 influences glutamate uptake by increasing the protein level of excitatory amino acid carrier (EAAC1). Excitatory Amino Acids 88-109 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Mus musculus 119-124 25943481-6 2015 Mice treated with 4 weeks of MPTP showed a 41% loss of vesicular monoamine transporter II (VMAT2), a 71% increase in the ratio of glycosylated/non-glycosylated dopamine transporter (DAT), and significant increases in glutamate transporters including VGLUT1, GLT-1, and excitatory amino acid carrier 1. Excitatory Amino Acids 269-290 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus 182-185 26726312-10 2015 Insulin sensitivity (ISI) and the total AUCins/glucose were significantly reduced by leucine/EAAs and phytosterol supplementation (P=0.008). Excitatory Amino Acids 93-97 insulin Homo sapiens 0-7 24511141-6 2014 Coadministration of DA with the broad spectrum excitatory amino acid antagonist kynurenic acid inhibited induction of c-fos, junb, and neutrophil gelatinase-associated lipocalin. Excitatory Amino Acids 47-68 FBJ osteosarcoma oncogene Mus musculus 118-123 25782288-7 2014 In both models expression of the excitatory amino acids carrier EAAT1 increased by about 40% as compared to control. Excitatory Amino Acids 33-55 solute carrier family 1 member 3 Rattus norvegicus 64-69 24511141-6 2014 Coadministration of DA with the broad spectrum excitatory amino acid antagonist kynurenic acid inhibited induction of c-fos, junb, and neutrophil gelatinase-associated lipocalin. Excitatory Amino Acids 47-68 jun B proto-oncogene Mus musculus 125-129 24511141-6 2014 Coadministration of DA with the broad spectrum excitatory amino acid antagonist kynurenic acid inhibited induction of c-fos, junb, and neutrophil gelatinase-associated lipocalin. Excitatory Amino Acids 47-68 lipocalin 2 Mus musculus 135-177 23907512-10 2013 The cleavage of CRMP2 may be a promising target for excitatory amino acid-related ischemic and hypoxic injury. Excitatory Amino Acids 52-73 dihydropyrimidinase like 2 Homo sapiens 16-21 24680664-2 2014 It is a murine homolog of human JWA and rat glutamate transporter-associated protein 3-18 (GTRAP3-18), a negative modulator of the neural glutamate transporter excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 160-181 ADP ribosylation factor like GTPase 6 interacting protein 5 Homo sapiens 32-35 24680664-2 2014 It is a murine homolog of human JWA and rat glutamate transporter-associated protein 3-18 (GTRAP3-18), a negative modulator of the neural glutamate transporter excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 160-181 ADP-ribosylation factor like GTPase 6 interacting protein 5 Rattus norvegicus 44-89 24680664-2 2014 It is a murine homolog of human JWA and rat glutamate transporter-associated protein 3-18 (GTRAP3-18), a negative modulator of the neural glutamate transporter excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 160-181 ADP-ribosylation factor like GTPase 6 interacting protein 5 Rattus norvegicus 91-100 24680664-2 2014 It is a murine homolog of human JWA and rat glutamate transporter-associated protein 3-18 (GTRAP3-18), a negative modulator of the neural glutamate transporter excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 160-181 solute carrier family 1 member 1 Rattus norvegicus 193-198 24476474-8 2014 Phosphorylation of mTOR and p70S6k was elevated to a larger extent following 1 h of recovery with leucine in the supplement (120% vs. 49% (p < 0.05) and 59- vs. 8-fold (p < 0.05) for EAA and EAA-Leu, respectively). Excitatory Amino Acids 189-192 mechanistic target of rapamycin kinase Homo sapiens 19-23 24476474-8 2014 Phosphorylation of mTOR and p70S6k was elevated to a larger extent following 1 h of recovery with leucine in the supplement (120% vs. 49% (p < 0.05) and 59- vs. 8-fold (p < 0.05) for EAA and EAA-Leu, respectively). Excitatory Amino Acids 189-192 ribosomal protein S6 kinase B1 Homo sapiens 28-34 24476474-8 2014 Phosphorylation of mTOR and p70S6k was elevated to a larger extent following 1 h of recovery with leucine in the supplement (120% vs. 49% (p < 0.05) and 59- vs. 8-fold (p < 0.05) for EAA and EAA-Leu, respectively). Excitatory Amino Acids 197-200 mechanistic target of rapamycin kinase Homo sapiens 19-23 24476474-8 2014 Phosphorylation of mTOR and p70S6k was elevated to a larger extent following 1 h of recovery with leucine in the supplement (120% vs. 49% (p < 0.05) and 59- vs. 8-fold (p < 0.05) for EAA and EAA-Leu, respectively). Excitatory Amino Acids 197-200 ribosomal protein S6 kinase B1 Homo sapiens 28-34 24290447-0 2013 TGF-beta1 attenuates spinal neuroinflammation and the excitatory amino acid system in rats with neuropathic pain. Excitatory Amino Acids 54-75 transforming growth factor, beta 1 Rattus norvegicus 0-9 24290447-9 2013 TGF-beta1 significantly attenuated the CCI-induced downregulation of glutamate transporter 1, the glutamate aspartate transporter, and the excitatory amino acid carrier 1 on the ipsilateral side. Excitatory Amino Acids 139-160 transforming growth factor, beta 1 Rattus norvegicus 0-9 24290447-11 2013 TGF-beta1 significantly decreased the concentrations of 2 excitatory amino acids, aspartate and glutamate, in the spinal dialysates in CCI rats. Excitatory Amino Acids 58-80 transforming growth factor, beta 1 Rattus norvegicus 0-9 24290447-13 2013 TGF-beta1 in neuropathy may include attenuation of spinal neuroinflammation, attenuation, or upregulation of glutamate transporter downregulation, and a decrease of spinal extracellular excitatory amino acids. Excitatory Amino Acids 186-208 transforming growth factor, beta 1 Rattus norvegicus 0-9 22859703-1 2012 Glutamate transporters (GLT-1, GLAST, EAAC1) limit the actions of excitatory amino acids. Excitatory Amino Acids 66-88 solute carrier family 1 member 2 Homo sapiens 24-29 22985769-1 2012 A highly sulfated chondroitin sulfate, CS-E, prevents excitatory amino acid-induced neuronal cell death by an as yet unknown mechanism. Excitatory Amino Acids 54-75 choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity) Homo sapiens 39-43 23026373-0 2012 Effect of bFGF on neuronal damage induced by sequential treatment of amyloid beta and excitatory amino acid in vitro and in vivo. Excitatory Amino Acids 86-107 fibroblast growth factor 2 Rattus norvegicus 10-14 22859703-1 2012 Glutamate transporters (GLT-1, GLAST, EAAC1) limit the actions of excitatory amino acids. Excitatory Amino Acids 66-88 solute carrier family 1 member 3 Homo sapiens 31-36 22859703-1 2012 Glutamate transporters (GLT-1, GLAST, EAAC1) limit the actions of excitatory amino acids. Excitatory Amino Acids 66-88 solute carrier family 1 member 1 Homo sapiens 38-43 22531293-2 2012 A genetic risk factor for these secondary OCS was recently described in the gene SLC1A1 encoding the neuronal glutamate transporter excitatory amino acid carrier 1. Excitatory Amino Acids 132-153 solute carrier family 1 member 1 Homo sapiens 81-87 22575539-1 2012 The excitatory amino acids glutamate and cysteine are actively transported into neurons from the extracellular space by the high affinity glutamate transporter EAAC1. Excitatory Amino Acids 4-26 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Mus musculus 160-165 22261079-0 2012 Expression of N-methyl-d-aspartate receptor 1 and its phosphorylated state in basal ganglia of a neonatal piglet hypoxic-ischemic brain injury model: a controlled study of (1)H MRS. Excitatory amino acids (EAAs) and excitotoxicity medicated by receptors of these amino acids play an important role in hypoxic-ischemic brain injury (HIBI), but most studies were ex vivo experiments, the mechanism in vivo is not well understood. Excitatory Amino Acids 182-204 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens 14-45 22707712-1 2012 Forward glutamate transport by the excitatory amino acid carrier EAAC1 is coupled to the inward movement of three Na(+) and one proton and the subsequent outward movement of one K(+) in a separate step. Excitatory Amino Acids 35-56 solute carrier family 1 member 1 Homo sapiens 65-70 22888325-2 2012 A screen for genes associated with mechanical load-induced bone formation identified the glutamate transporter GLAST, implicating the excitatory amino acid, glutamate, in the mechanoresponse. Excitatory Amino Acids 134-155 solute carrier family 1 member 3 Rattus norvegicus 111-116 22473757-3 2012 The current study was carried out to ascertain whether insulin-induced hypoglycemic suppression of the HPG axis involves modulation of responsiveness of the GnRH neuron to kisspeptin and excitatory amino acids (EAA) drives. Excitatory Amino Acids 187-209 gonadotropin releasing hormone 1 Macaca mulatta 157-161 22473757-3 2012 The current study was carried out to ascertain whether insulin-induced hypoglycemic suppression of the HPG axis involves modulation of responsiveness of the GnRH neuron to kisspeptin and excitatory amino acids (EAA) drives. Excitatory Amino Acids 211-214 gonadotropin releasing hormone 1 Macaca mulatta 157-161 22385043-0 2012 RANTES-mediated control of excitatory amino acid release in mouse spinal cord. Excitatory Amino Acids 27-48 chemokine (C-C motif) ligand 5 Mus musculus 0-6 25767487-3 2012 At 7 days post-ischemia, expression of excitatory amino acid carrier 1 decreased in the hippocampal CA1 region and cortex, and was accompanied by apoptosis. Excitatory Amino Acids 39-60 carbonic anhydrase 1 Rattus norvegicus 100-103 21293890-5 2012 Significant increases in [free IGF-I] and [leucine] were observed in the EAA/CHO group only. Excitatory Amino Acids 73-76 insulin like growth factor 1 Homo sapiens 31-36 22919417-5 2012 The in vivo pancreatic lipase activity was evaluated by measurement of plasma triacylglycerol levels after oral administration of EAA along with lipid emulsion to Swiss albino mice. Excitatory Amino Acids 130-133 lipase, endothelial Mus musculus 23-29 22640615-3 2012 Glutamate, as the major excitatory amino acid neurotransmitter in the hypothalamus, was shown to mediate orexin neurons in the regulation of wakefulness and feeding. Excitatory Amino Acids 24-45 hypocretin neuropeptide precursor Homo sapiens 105-111 21903926-5 2011 In neurons, TRF2-S-mediated antagonism of REST nuclear activity is greatly attenuated by either overexpression of TRF2 or administration of the excitatory amino acid kainic acid. Excitatory Amino Acids 144-165 telomeric repeat binding factor 2 Homo sapiens 12-16 21766339-0 2011 Increased excitatory amino acid transport into murine prion protein knockout astrocytes cultured in vitro. Excitatory Amino Acids 10-31 prion protein Mus musculus 54-67 21781115-0 2011 Functional characterization of vesicular excitatory amino acid transport by human sialin. Excitatory Amino Acids 41-62 solute carrier family 17 member 5 Homo sapiens 82-88 20654639-2 2010 We investigated the effects of corticosterone on the activity of a glutamate transporter, excitatory amino acid carrier 1 (EAAC1; also called excitatory amino acid transporter type 3 [EAAT3]), and the roles of protein kinase C (PKC) and phosphatidylinositol 3-kinase (PI3K) in regulating these effects. Excitatory Amino Acids 90-111 solute carrier family 1 member 1 Rattus norvegicus 123-128 20853444-11 2011 These results show that in the presence of a metabolic insult a higher release of excitatory amino acids occurs, which may underlay the neuronal injury observed in type 1 diabetic patients under insulin therapy. Excitatory Amino Acids 82-104 insulin Homo sapiens 195-202 21405954-2 2011 A previous proteomic study from our laboratory showed that expression of PDGFRalpha is elevated considerably in the retinas of an animal model of glaucoma-the excitatory amino acid carrier (EAAC) 1-deficient (EAAC1-/-) mouse. Excitatory Amino Acids 159-180 platelet derived growth factor receptor, alpha polypeptide Mus musculus 73-83 21405954-2 2011 A previous proteomic study from our laboratory showed that expression of PDGFRalpha is elevated considerably in the retinas of an animal model of glaucoma-the excitatory amino acid carrier (EAAC) 1-deficient (EAAC1-/-) mouse. Excitatory Amino Acids 159-180 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Mus musculus 209-214 20851111-3 2010 GnRH secretion is stimulated by transsynaptic inputs provided by excitatory amino acids (glutamate) and at least one peptide (kisspeptin), and by glial inputs provided by growth factors and small bioactive molecules. Excitatory Amino Acids 65-87 gonadotropin releasing hormone 1 Homo sapiens 0-4 20727120-1 2010 The glutamate transporter excitatory amino acid carrier (EAAC1/EAAT3) mediates the absorption of dicarboxylic amino acids in epithelial cells as well as the uptake of glutamate from the synaptic cleft. Excitatory Amino Acids 26-47 solute carrier family 1 member 1 Canis lupus familiaris 57-62 20599932-11 2010 Taken together, these results provide evidence that bromocriptine inhibits excitatory amino acid release via reversed operation of GLT-1 without altering forward transport. Excitatory Amino Acids 75-96 solute carrier family 1 member 2 Homo sapiens 131-136 20181846-16 2010 CNP protects rat RGCs against the apoptotic damage induced by insults such as excitatory amino acid, both in vitro and in vivo. Excitatory Amino Acids 78-99 natriuretic peptide C Rattus norvegicus 0-3 20554931-3 2010 In addition, in vitro studies indicate that excitatory amino acids may also be critical for central oxytocin secretion, although in vivo experiments have not provided direct support for this hypothesis. Excitatory Amino Acids 44-66 oxytocin/neurophysin I prepropeptide Homo sapiens 100-108 19294370-7 2009 The mechanism of the increase in responses to excitatory amino acids includes phosphorylation of NR1 subunits of NMDA receptors and GluR1 subunits of AMPA receptors. Excitatory Amino Acids 46-68 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens 97-100 19932886-0 2010 Suppressive effects of intrathecal granulocyte colony-stimulating factor on excessive release of excitatory amino acids in the spinal cerebrospinal fluid of rats with cord ischemia: role of glutamate transporters. Excitatory Amino Acids 97-119 colony stimulating factor 3 Rattus norvegicus 35-72 19574577-5 2009 We suggest that excitatory amino acids, nitric oxide, inflammation, trophic factor withdrawal, and an increased pro- versus antiapoptotic Bcl-2 protein ratio will trigger Bax-dependent mitochondrial outer membrane permeabilization. Excitatory Amino Acids 16-38 BCL2 associated X, apoptosis regulator Homo sapiens 171-174 20378543-1 2010 The glutamate transporter excitatory amino acid carrier 1 (EAAC1) catalyzes the co-transport of three Na(+) ions, one H(+) ion, and one glutamate molecule into the cell, in exchange for one K(+) ion. Excitatory Amino Acids 26-47 solute carrier family 1 member 1 Homo sapiens 59-64 20306720-4 2009 Between P3 and P15, a significant increment in the levels of excitatory amino acids, Asp and Glu, were observed in mice exposed to PQ, as compared with the control group. Excitatory Amino Acids 61-83 cyclin dependent kinase inhibitor 2B Mus musculus 15-18 19666192-4 2009 Twenty four hour pre-treatment with TRH and its analogues in low micromolar concentrations attenuated the neuronal cell death evoked by excitatory amino acids (EAAs: glutamate, NMDA, kainate, quisqualate) and hydrogen peroxide. Excitatory Amino Acids 136-158 thyrotropin releasing hormone Mus musculus 36-39 19294370-7 2009 The mechanism of the increase in responses to excitatory amino acids includes phosphorylation of NR1 subunits of NMDA receptors and GluR1 subunits of AMPA receptors. Excitatory Amino Acids 46-68 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 132-137 19409222-6 2009 Ultra-low dose naloxone plus morphine significantly inhibited the effect of PTX on P-p38 MAPK expression in the spinal cord, while the p38 MAPK inhibitor SB203580 attenuated the PTX-induced mechanical allodynia, thermal hyperalgesia, increase in spinal cerebrospinal fluid excitatory amino acids, and downregulation of GTs. Excitatory Amino Acids 273-295 mitogen activated protein kinase 14 Rattus norvegicus 135-138 18854198-0 2009 The NMDA antagonist MK-801 induces hyperalgesia and increases CSF excitatory amino acids in rats: reversal by guanosine. Excitatory Amino Acids 66-88 colony stimulating factor 2 Rattus norvegicus 62-65 18663473-3 2008 Fos-ir was assessed after intra-pallidal injections of the excitatory amino acid agonist, NMDA, or the GABA(A) antagonist, bicuculline in normal rats and in those rendered Parkinsonian-like by lesioning dopaminergic neurons with the neurotoxin, 6-OHDA. Excitatory Amino Acids 59-80 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-3 18986164-1 2008 The excitatory amino acid carrier EAAC1 belongs to a family of glutamate transporters that use the electrochemical transmembrane gradients of sodium and potassium to mediate uphill transport of glutamate into the cell. Excitatory Amino Acids 4-25 solute carrier family 1 member 1 Homo sapiens 34-39 18703755-4 2008 GLT1 regulates extracellular concentrations of glutamate, an excitatory amino acid involved in the pathogenesis of seizures and epilepsy. Excitatory Amino Acids 61-82 solute carrier family 1 (glial high affinity glutamate transporter), member 2 Mus musculus 0-4 18503079-4 2008 JWA, a newly identified microtubule-binding protein, was shown to regulate cell stress responses, transportation of intracellular excitatory amino acids, and the MAPK signal transduction pathway. Excitatory Amino Acids 130-152 Jwa Drosophila melanogaster 0-3 18684713-1 2008 Addicsin (Arl6ip5) is a murine homologue of rat glutamate transporter-associated protein 3-18 (GTRAP3-18), a putative negative modulator of Na+-dependent neural glutamate transporter-excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 183-204 ADP-ribosylation factor-like 6 interacting protein 5 Mus musculus 0-8 18684713-1 2008 Addicsin (Arl6ip5) is a murine homologue of rat glutamate transporter-associated protein 3-18 (GTRAP3-18), a putative negative modulator of Na+-dependent neural glutamate transporter-excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 183-204 ADP-ribosylation factor-like 6 interacting protein 5 Mus musculus 10-17 18684713-1 2008 Addicsin (Arl6ip5) is a murine homologue of rat glutamate transporter-associated protein 3-18 (GTRAP3-18), a putative negative modulator of Na+-dependent neural glutamate transporter-excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 183-204 ADP-ribosylation factor like GTPase 6 interacting protein 5 Rattus norvegicus 48-93 18684713-1 2008 Addicsin (Arl6ip5) is a murine homologue of rat glutamate transporter-associated protein 3-18 (GTRAP3-18), a putative negative modulator of Na+-dependent neural glutamate transporter-excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 183-204 ADP-ribosylation factor like GTPase 6 interacting protein 5 Rattus norvegicus 95-104 18556052-0 2008 Effect of a metabotropic glutamate receptor 5 antagonist, MPEP, on the nociceptive response induced by intrathecal injection of excitatory aminoacids, substance P, bradykinin or cytokines in mice. Excitatory Amino Acids 128-149 glutamate receptor, metabotropic 5 Mus musculus 12-45 18588864-1 2008 The toxicity of organophosphorous (OP) nerve agents is attributed to their irreversible inhibition of acetylcholinesterase (AChE), which leads to excessive accumulation of acetylcholine (ACh) and is followed by the release of excitatory amino acids (EAA). Excitatory Amino Acids 226-248 acetylcholinesterase Rattus norvegicus 102-122 18588864-1 2008 The toxicity of organophosphorous (OP) nerve agents is attributed to their irreversible inhibition of acetylcholinesterase (AChE), which leads to excessive accumulation of acetylcholine (ACh) and is followed by the release of excitatory amino acids (EAA). Excitatory Amino Acids 226-248 acetylcholinesterase Rattus norvegicus 124-128 18588864-1 2008 The toxicity of organophosphorous (OP) nerve agents is attributed to their irreversible inhibition of acetylcholinesterase (AChE), which leads to excessive accumulation of acetylcholine (ACh) and is followed by the release of excitatory amino acids (EAA). Excitatory Amino Acids 250-253 acetylcholinesterase Rattus norvegicus 102-122 18588864-1 2008 The toxicity of organophosphorous (OP) nerve agents is attributed to their irreversible inhibition of acetylcholinesterase (AChE), which leads to excessive accumulation of acetylcholine (ACh) and is followed by the release of excitatory amino acids (EAA). Excitatory Amino Acids 250-253 acetylcholinesterase Rattus norvegicus 124-128 18556069-1 2008 Intense seizure activity associated with status epilepticus and excitatory amino acid (EAA) imbalance initiates oxidative damage and neuronal injury in CA1 of the ventral hippocampus. Excitatory Amino Acids 64-85 carbonic anhydrase 1 Mus musculus 152-155 18556069-1 2008 Intense seizure activity associated with status epilepticus and excitatory amino acid (EAA) imbalance initiates oxidative damage and neuronal injury in CA1 of the ventral hippocampus. Excitatory Amino Acids 87-90 carbonic anhydrase 1 Mus musculus 152-155 18315563-9 2008 These data suggest that ATP regulates VRAC activity and volume-sensitive excitatory amino acid release via cooperative activation of PKCalpha and betaI. Excitatory Amino Acids 73-94 protein kinase C, alpha Rattus norvegicus 133-141 18673210-8 2008 Importantly, sPLA(2) may act as a convergence molecule that mediates multiple key mechanisms involved in the secondary injury since it can be induced by multiple toxic factors such as inflammatory cytokines, free radicals, and excitatory amino acids, and its activation and metabolites can exacerbate the secondary injury. Excitatory Amino Acids 227-249 phospholipase A2 group X Homo sapiens 13-20 17996021-0 2008 A highly sulfated chondroitin sulfate preparation, CS-E, prevents excitatory amino acid-induced neuronal cell death. Excitatory Amino Acids 66-87 choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity) Homo sapiens 51-55 18255055-4 2008 Emerging from these studies, is a picture of complex interactions between the stress-related neuropeptide, corticotropin-releasing factor (CRF), endogenous opioids and the excitatory amino acid neurotransmitter, glutamate. Excitatory Amino Acids 172-193 corticotropin releasing hormone Homo sapiens 107-137 18164823-8 2008 These results indicate that CB1 receptor activation modulates SNpc neuronal activity by an indirect mechanism involving excitatory amino acids, probably released from STN axon terminals in the SNpc. Excitatory Amino Acids 120-142 cannabinoid receptor 1 Rattus norvegicus 28-31 17963758-1 2008 Marked hippocampal changes in response to excitatory amino acid agonists occur during pregnancy (e.g. decreased frequency in spontaneous recurrent seizures in rats with KA lesions of the hippocampus) and lactation (e.g. reduced c-Fos expression in response to N-methyl-d,l-aspartic acid but not to kainic acid). Excitatory Amino Acids 42-63 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 228-233 18056791-1 2008 We recently showed that resistance exercise and ingestion of essential amino acids with carbohydrate (EAA+CHO) can independently stimulate mammalian target of rapamycin (mTOR) signaling and muscle protein synthesis in humans. Excitatory Amino Acids 102-105 mechanistic target of rapamycin kinase Homo sapiens 139-168 18056791-1 2008 We recently showed that resistance exercise and ingestion of essential amino acids with carbohydrate (EAA+CHO) can independently stimulate mammalian target of rapamycin (mTOR) signaling and muscle protein synthesis in humans. Excitatory Amino Acids 102-105 mechanistic target of rapamycin kinase Homo sapiens 170-174 18056791-12 2008 4E-BP1 phosphorylation returned to baseline during recovery in control but became elevated when EAA+CHO was ingested (P < 0.05). Excitatory Amino Acids 96-99 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 0-6 17897781-2 2007 This protein is considered to function as a modulator of the neural glutamate transporter excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 90-111 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Mus musculus 123-128 18655870-6 2008 Using this approach, we found that Avp but not Oxt gene expression increased after acute (2-5h) combined excitatory amino acid agonist and GABA antagonist treatment, similar to what we found after an acute hyperosmotic stimulus. Excitatory Amino Acids 105-126 arginine vasopressin Rattus norvegicus 35-38 17991780-1 2007 Glutamate transport by the excitatory amino acid carrier EAAC1 is known to be reversible. Excitatory Amino Acids 27-48 solute carrier family 1 member 1 Homo sapiens 57-62 17392736-3 2007 Depression is associated with hippocampal plasticity, for which increased excitatory amino acid (EAA) release in CA3 induced by chronic stress is responsible, and glucocorticoids have a permissive role and act synergistically with EAAs in producing neuronal damage. Excitatory Amino Acids 74-95 carbonic anhydrase 3 Rattus norvegicus 113-116 17392736-3 2007 Depression is associated with hippocampal plasticity, for which increased excitatory amino acid (EAA) release in CA3 induced by chronic stress is responsible, and glucocorticoids have a permissive role and act synergistically with EAAs in producing neuronal damage. Excitatory Amino Acids 97-100 carbonic anhydrase 3 Rattus norvegicus 113-116 17898305-2 2007 Previously, the authors induced death in the RGC-5 cell line using very high concentrations (1 mM) of the excitatory amino acids glutamate (Glu) and homocysteine (Hcy) and demonstrated that the sigmaR1 ligand (+)-pentazocine ((+)-PTZ) could protect against cell death. Excitatory Amino Acids 106-128 sigma non-opioid intracellular receptor 1 Mus musculus 194-201 17463163-3 2007 For example, glutamate, the major excitatory amino acid in the brain, directly regulates GnRH release from nerve terminals via NMDA receptors (NMDARs). Excitatory Amino Acids 34-55 gonadotropin releasing hormone 1 Homo sapiens 89-93 17459877-1 2007 The neuronal transporter excitatory amino acid carrier 1 (EAAC1) is enriched in perisynaptic regions, where it may regulate synaptic spillover of glutamate. Excitatory Amino Acids 25-46 solute carrier family 1 member 1 Homo sapiens 58-63 17109834-0 2006 Down-regulation of glutaredoxin by estrogen receptor antagonist renders female mice susceptible to excitatory amino acid mediated complex I inhibition in CNS. Excitatory Amino Acids 99-120 glutaredoxin Mus musculus 19-31 17456392-12 2007 CONCLUSION: The overactivation of NMDAR1 is the main route by which excitatory amino acids chose to join the development of acute intoxicated encephalopathy induced by 1,2-DCE. Excitatory Amino Acids 68-90 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 34-40 17455090-1 2007 Excitatory amino acids (EAAs) mediate their effects through the glutamate receptors (GluRs) in the brain. Excitatory Amino Acids 0-22 glutamyl-tRNA synthetase 2, mitochondrial Homo sapiens 64-83 17455090-1 2007 Excitatory amino acids (EAAs) mediate their effects through the glutamate receptors (GluRs) in the brain. Excitatory Amino Acids 0-22 glutamyl-tRNA synthetase 2, mitochondrial Homo sapiens 85-90 17095121-0 2007 Inhibition of cystathionine-gamma-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS. Excitatory Amino Acids 126-147 cystathionase (cystathionine gamma-lyase) Mus musculus 14-39 16911580-0 2006 Stimulation of excitatory amino acid release from adult mouse brain glia subcellular particles by high mobility group box 1 protein. Excitatory Amino Acids 15-36 high mobility group box 1 Mus musculus 98-123 16800850-1 2006 EAAC1/EAAT3 is a transporter of glutamate (Glu) present at the post-synaptic neuronal element, in opposition to the two other main transporters, GLAST/EAAT1 and GLT1/EAAT2, expressed at the excitatory amino acid (EAA) synapse by surrounding astrocytes. Excitatory Amino Acids 0-3 solute carrier family 1 member 3 Homo sapiens 151-156 16759803-4 2006 These findings suggest the hypothesis that excitatory amino acid release plays a role in regulation of postsynaptic 5-HT2A receptors, and that down-regulation of 5-HT2A receptors by 5-HT2A agonists may not be attributed only to simple occupancy of the receptor by direct agonists. Excitatory Amino Acids 43-64 5-hydroxytryptamine receptor 2A Rattus norvegicus 116-122 16800850-1 2006 EAAC1/EAAT3 is a transporter of glutamate (Glu) present at the post-synaptic neuronal element, in opposition to the two other main transporters, GLAST/EAAT1 and GLT1/EAAT2, expressed at the excitatory amino acid (EAA) synapse by surrounding astrocytes. Excitatory Amino Acids 0-3 solute carrier family 1 member 2 Homo sapiens 166-171 16800850-1 2006 EAAC1/EAAT3 is a transporter of glutamate (Glu) present at the post-synaptic neuronal element, in opposition to the two other main transporters, GLAST/EAAT1 and GLT1/EAAT2, expressed at the excitatory amino acid (EAA) synapse by surrounding astrocytes. Excitatory Amino Acids 190-211 solute carrier family 1 member 1 Homo sapiens 0-5 16800850-1 2006 EAAC1/EAAT3 is a transporter of glutamate (Glu) present at the post-synaptic neuronal element, in opposition to the two other main transporters, GLAST/EAAT1 and GLT1/EAAT2, expressed at the excitatory amino acid (EAA) synapse by surrounding astrocytes. Excitatory Amino Acids 190-211 solute carrier family 1 member 1 Homo sapiens 6-11 16539654-10 2006 These data indicate for the first time that tTG may play an active role in excitatory amino acid-induced neuronal cell death, which has been postulated to be an important component of acute CNS injury and chronic CNS neurodegenerative conditions. Excitatory Amino Acids 75-96 transglutaminase 2, C polypeptide Mus musculus 44-47 16800850-1 2006 EAAC1/EAAT3 is a transporter of glutamate (Glu) present at the post-synaptic neuronal element, in opposition to the two other main transporters, GLAST/EAAT1 and GLT1/EAAT2, expressed at the excitatory amino acid (EAA) synapse by surrounding astrocytes. Excitatory Amino Acids 190-211 solute carrier family 1 member 3 Homo sapiens 145-150 16800850-1 2006 EAAC1/EAAT3 is a transporter of glutamate (Glu) present at the post-synaptic neuronal element, in opposition to the two other main transporters, GLAST/EAAT1 and GLT1/EAAT2, expressed at the excitatory amino acid (EAA) synapse by surrounding astrocytes. Excitatory Amino Acids 190-211 solute carrier family 1 member 2 Homo sapiens 166-171 16800850-1 2006 EAAC1/EAAT3 is a transporter of glutamate (Glu) present at the post-synaptic neuronal element, in opposition to the two other main transporters, GLAST/EAAT1 and GLT1/EAAT2, expressed at the excitatory amino acid (EAA) synapse by surrounding astrocytes. Excitatory Amino Acids 0-3 solute carrier family 1 member 1 Homo sapiens 6-11 16388118-0 2005 Control of ACTH secretion by excitatory amino acids: functional significance and clinical implications. Excitatory Amino Acids 29-51 proopiomelanocortin Homo sapiens 11-15 16496131-8 2006 CONCLUSIONS: These data suggest that VPA salts significantly modulate the activity of excitatory amino acid at mPFC pyramidal neurons and this mechanism should explain the therapeutic effects of valproate in psychiatric diseases involving NMDA, AMPA, and kainate receptors at the mPFC level. Excitatory Amino Acids 86-107 complement factor properdin Mus musculus 111-115 16496131-8 2006 CONCLUSIONS: These data suggest that VPA salts significantly modulate the activity of excitatory amino acid at mPFC pyramidal neurons and this mechanism should explain the therapeutic effects of valproate in psychiatric diseases involving NMDA, AMPA, and kainate receptors at the mPFC level. Excitatory Amino Acids 86-107 complement factor properdin Mus musculus 280-284 16399672-4 2006 Because the metalloproteinase tumor necrosis factor alpha converting enzyme (TACE) releases TGFalpha from its transmembrane precursor before TGFalpha can bind to erbB1 receptors, we sought to determine whether TACE is required for excitatory amino acids to activate the TGFalpha-erbB1 signaling module in hypothalamic astrocytes, and thus facilitate the advent of puberty. Excitatory Amino Acids 231-253 ADAM metallopeptidase domain 17 Homo sapiens 77-81 16388118-1 2005 The involvement of excitatory amino acids in the control of ACTH release is well established. Excitatory Amino Acids 19-41 proopiomelanocortin Homo sapiens 60-64 16388119-0 2005 Role of excitatory amino acids in the control of growth hormone secretion. Excitatory Amino Acids 8-30 gonadotropin releasing hormone receptor Rattus norvegicus 49-63 16388120-0 2005 Control of prolactin secretion by excitatory amino acids. Excitatory Amino Acids 34-56 prolactin Rattus norvegicus 11-20 16388120-1 2005 This article provides an overview of the increasing number of observations indicating that excitatory amino acids are involved in the control of prolactin secretion. Excitatory Amino Acids 91-113 prolactin Rattus norvegicus 145-154 16005150-1 2005 Addicsin is a murine homologue of rat glutamate-transporter-associated protein 3-18 (GTRAP3-18), a putative modulator of neural glutamate-transporter excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 150-171 ADP-ribosylation factor-like 6 interacting protein 5 Mus musculus 0-8 16303975-2 2005 One factor involves excitatory amino acid stimulation of N-methyl-D-aspartate (NMDA)-type glutamate receptors, excessive Ca2+ influx, and formation of nitric oxide (NO) via neuronal NO synthase (nNOS). Excitatory Amino Acids 20-41 nitric oxide synthase 1, neuronal Mus musculus 195-199 16005150-1 2005 Addicsin is a murine homologue of rat glutamate-transporter-associated protein 3-18 (GTRAP3-18), a putative modulator of neural glutamate-transporter excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 150-171 ADP-ribosylation factor like GTPase 6 interacting protein 5 Rattus norvegicus 38-83 16005150-1 2005 Addicsin is a murine homologue of rat glutamate-transporter-associated protein 3-18 (GTRAP3-18), a putative modulator of neural glutamate-transporter excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 150-171 ADP-ribosylation factor like GTPase 6 interacting protein 5 Rattus norvegicus 85-94 16005150-1 2005 Addicsin is a murine homologue of rat glutamate-transporter-associated protein 3-18 (GTRAP3-18), a putative modulator of neural glutamate-transporter excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 150-171 solute carrier family 1 member 1 Rattus norvegicus 183-188 16045453-2 2005 Our recent studies suggest that one of the classical subtypes of PKC, PKCalpha, may selectively mediate redistribution of the neuronal glutamate transporter, excitatory amino acid carrier (EAAC)1, and show that PKCalpha can be co-immunoprecipitated with EAAC1. Excitatory Amino Acids 158-179 protein kinase C, alpha Rattus norvegicus 65-68 16045453-2 2005 Our recent studies suggest that one of the classical subtypes of PKC, PKCalpha, may selectively mediate redistribution of the neuronal glutamate transporter, excitatory amino acid carrier (EAAC)1, and show that PKCalpha can be co-immunoprecipitated with EAAC1. Excitatory Amino Acids 158-179 protein kinase C, alpha Rattus norvegicus 70-78 15789271-0 2005 Leptin stimulates the reproductive male axis in rats during sexual maturation by acting on hypothalamic excitatory amino acids. Excitatory Amino Acids 104-126 leptin Rattus norvegicus 0-6 15927765-6 2005 In general, excitatory amino acids stimulate release of luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone (GH), and prolactin (PRL). Excitatory Amino Acids 12-34 prolactin Sus scrofa 143-152 15992581-2 2005 The aim of this investigation was to directly characterise nAChR-evoked release of excitatory amino acids from rat frontal cortex, by monitoring the release of [3H]D-aspartate from superfused synaptosomes or minces. Excitatory Amino Acids 83-105 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 59-64 15736956-1 2005 Transmembrane glutamate transport by the excitatory amino acid carrier (EAAC1) is coupled to the cotransport of three Na(+) ions and one proton. Excitatory Amino Acids 41-62 solute carrier family 1 member 1 Homo sapiens 72-77 15637288-9 2005 Finally, mechanistic studies revealed that the ability of KiSS-1 to elicit FSH secretion was abolished by the blockade of endogenous GnRH actions, but it was persistently observed in different models of leptin insufficiency and after blockade of endogenous excitatory amino acid and nitric oxide pathways, i.e. relevant signals in the neuroendocrine control of gonadotropin secretion. Excitatory Amino Acids 257-278 KiSS-1 metastasis-suppressor Rattus norvegicus 58-64 15375028-11 2005 Finally, the LH-releasing activity of KiSS-1 was persistently observed after blockade of endogenous excitatory amino acid and nitric oxide pathways, i.e. relevant neurotransmitters in the neuroendocrine control of LH secretion. Excitatory Amino Acids 100-121 KiSS-1 metastasis suppressor Homo sapiens 38-44 15569671-0 2005 Hydrogen peroxide potentiates volume-sensitive excitatory amino acid release via a mechanism involving Ca2+/calmodulin-dependent protein kinase II. Excitatory Amino Acids 47-68 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 103-146 15569671-7 2005 The H2O2-induced component of EAA release was attenuated by the Ca2+ chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-acetoxymethyl ester (BAPTA-AM) and completely eliminated by the calmodulin antagonists trifluoperazine and W-7 and the Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93. Excitatory Amino Acids 30-33 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 254-297 15569671-7 2005 The H2O2-induced component of EAA release was attenuated by the Ca2+ chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-acetoxymethyl ester (BAPTA-AM) and completely eliminated by the calmodulin antagonists trifluoperazine and W-7 and the Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93. Excitatory Amino Acids 30-33 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 299-305 15536493-0 2005 Release of oxytocin in the rat central amygdala modulates stress-coping behavior and the release of excitatory amino acids. Excitatory Amino Acids 100-122 oxytocin/neurophysin I prepropeptide Rattus norvegicus 11-19 15536493-6 2005 Simultaneously, local administration of the OXT receptor antagonist caused a significant increase in the stress-induced release of the excitatory amino acids glutamate and aspartate, whereas the basal release of these amino acids remained unchanged. Excitatory Amino Acids 135-157 oxytocin/neurophysin I prepropeptide Rattus norvegicus 44-47 15536493-8 2005 Furthermore, our data indicate that OXT receptor-mediated mechanisms within the amygdala are involved in the generation of passive stress-coping strategies, which might be mediated at least in part via its inhibitory influence on the local release of excitatory amino acids during stress. Excitatory Amino Acids 251-273 oxytocin/neurophysin I prepropeptide Rattus norvegicus 36-39 16433257-8 2005 ), an antagonist of NMDA receptors of excitatory amino acid system (EAAs), antagonized the stimulatory effect of leptin on LH secretion and on the hypothalamic content of GLU. Excitatory Amino Acids 38-59 leptin Rattus norvegicus 113-119 15488547-3 2004 The activation of paraventricular oxytocinergic neurons by dopamine, oxytocin, excitatory amino acids and hexarelin analogue peptides is apparently mediated by the activation of nitric oxide (NO) synthase. Excitatory Amino Acids 79-101 oxytocin/neurophysin I prepropeptide Homo sapiens 34-42 15934319-0 2005 Effect of morphine and naloxone on release of the excitatory amino acids of spinal astrocytes induced by TNF-alpha. Excitatory Amino Acids 50-72 tumor necrosis factor Rattus norvegicus 105-114 15934319-1 2005 The effect of morphine and naloxone on release of the excitatory amino acids (EAAs) of spinal astrocytes induced by TNF-a was studied. Excitatory Amino Acids 54-76 tumor necrosis factor Rattus norvegicus 116-121 15934319-1 2005 The effect of morphine and naloxone on release of the excitatory amino acids (EAAs) of spinal astrocytes induced by TNF-a was studied. Excitatory Amino Acids 78-82 tumor necrosis factor Rattus norvegicus 116-121 15044176-7 2004 Molecular identity of the X(AG)(-) glutamate transporter, based on immunoblot and RT-PCR analysis, was primarily the defined excitatory amino acid carrier (EAAC)-1. Excitatory Amino Acids 125-146 solute carrier family 1 member 1 Sus scrofa 156-163 15363891-3 2004 Recent evidence has shown that exposure to excitatory amino acids regulates the expression of the antiapoptotic protein, Bcl-2, and the proapoptotic protein, Bax, in neurons. Excitatory Amino Acids 43-65 BCL2 apoptosis regulator Homo sapiens 121-126 15363891-3 2004 Recent evidence has shown that exposure to excitatory amino acids regulates the expression of the antiapoptotic protein, Bcl-2, and the proapoptotic protein, Bax, in neurons. Excitatory Amino Acids 43-65 BCL2 associated X, apoptosis regulator Homo sapiens 158-161 15275822-6 2004 Group III mGluRs such as mGluR8, because of their high affinity for glutamate, are particularly well suited to detect small changes in the concentration of this excitatory amino acid in the extracellular space. Excitatory Amino Acids 161-182 glutamate receptor, metabotropic 8 Mus musculus 25-31 15187084-11 2004 Our data suggest that the glutamate transporters, especially EAAT2, are associated with cholesterol-rich lipid raft microdomains of the plasma membrane and that the association with these cholesterol-rich microdomains is important for excitatory amino acid transporter localization and function. Excitatory Amino Acids 235-256 solute carrier family 1 (glial high affinity glutamate transporter), member 2 Mus musculus 61-66 15099921-7 2004 In particular, the major convulsant effects produced by NMDA, AMPA and KA suggest that the excitatory amino acid system is more active in the central nervous system (CNS) of IL-6(-/-) mice. Excitatory Amino Acids 91-112 interleukin 6 Mus musculus 174-178 15075380-7 2004 They also favored NR2A-versus NR2B- or NR2C-containing NMDA receptors, with EAA-090 showing the greatest selectivity. Excitatory Amino Acids 76-79 glutamate ionotropic receptor NMDA type subunit 2A Rattus norvegicus 18-22 15075380-7 2004 They also favored NR2A-versus NR2B- or NR2C-containing NMDA receptors, with EAA-090 showing the greatest selectivity. Excitatory Amino Acids 76-79 glutamate ionotropic receptor NMDA type subunit 2C Rattus norvegicus 39-43 15207918-4 2004 In this study, an in situ hybridisation technique has been used to elucidate changes in mRNA expression of the glutamate transporter, excitatory amino acid carrier 1 (EAAC1), after treatment with the tricyclic antidepressant (TCA) amitriptyline. Excitatory Amino Acids 134-155 solute carrier family 1 member 1 Rattus norvegicus 167-172 15183129-2 2004 Reverse transcription polymerase chain reaction revealed constitutive expression of mRNA for the neuronal GluT subtype excitatory amino acid carrier-1, in addition to glial subtypes such as glutamate aspartate transporter and glutamate transporter-1, in rat calvarial osteoblasts cultured for 7-21 days in vitro (DIV). Excitatory Amino Acids 119-140 glutaminase Rattus norvegicus 106-110 15473128-11 2004 These results indicate that leptin has an inhibitory effect on the GnRH-LH axis in adult male rats and this effect appears to be connected with an inhibition of hypothalamic release of GLU (the excitatory amino acid) and a stimulatory effect on GABA release (the inhibitory amino acid). Excitatory Amino Acids 194-215 leptin Rattus norvegicus 28-34 15285800-14 2004 CONCLUSIONS: These data suggest that Abeta could contribute to neurodegeneration through stimulating microglia to release cooperative excitatory amino acids, including D-serine. Excitatory Amino Acids 134-156 amyloid beta precursor protein Homo sapiens 37-42 12951633-11 2003 These results and previous reports suggest that at this stage of sexual maturation, leptin exerts an stimulatory effect on GnRH by inducing release of excitatory amino acids (ASP) and reducing release of inhibitory amino acids (GABA) involved in GnRH control. Excitatory Amino Acids 151-173 gonadotropin releasing hormone 1 Rattus norvegicus 123-127 15001711-1 2004 Chronic restraint stress, psychosocial stress, as well as systemic or oral administration of the stress-hormone corticosterone induces a morphological reorganization in the rat hippocampus, in which adrenal steroids and excitatory amino acids mediate a reversible remodeling of apical dendrites on CA3 pyramidal cell neurons of the hippocampus. Excitatory Amino Acids 220-242 carbonic anhydrase 3 Rattus norvegicus 298-301 15143625-2 2004 Here we report that t-ACPD, a metabotropic glutamate receptor (mGluR) agonist, produced small increases in CaBP-IR which was potentiated by a mGluR antagonist The increase in CaBPIR was not due to de novo protein synthesis because the translational inhibitors (cycloheximide and emetine) or transciptional inhibitors (actinomycine-D and a-amanitine), did not prevent the EAA enhanced CaBP-IR. Excitatory Amino Acids 371-374 S100 calcium binding protein G Rattus norvegicus 107-111 15018834-1 2004 Metabotropic glutamate receptors are a family of class III G-protein-coupled receptors comprising eight members (mGluR1-8), which are an attractive target in the central nervous system because of the widespread use of glutamate as the principal excitatory amino acid transmitter. Excitatory Amino Acids 245-266 glutamate metabotropic receptor 1 Homo sapiens 113-119 14761684-4 2004 Activation of nNOS was inhibited by the NMDARs inhibitor, MK 801, and by the calcium channel blocker, nimodipine, thus demonstrating a link to excitatory amino acids. Excitatory Amino Acids 143-165 nitric oxide synthase 1 Rattus norvegicus 14-18 14501969-0 2003 Relationship between apoE4 allele and excitatory amino acid levels after traumatic brain injury. Excitatory Amino Acids 38-59 apolipoprotein E Homo sapiens 21-26 15003285-8 2004 These results suggest that peripheral cytokine can produce mechanical allodynia in the orofacial area and that excitatory amino acids can modulate IL-1beta-induced mechanical allodynia via non-NMDA receptors. Excitatory Amino Acids 111-133 interleukin 1 beta Rattus norvegicus 147-155 14672815-0 2004 Increasing of intrathecal CSF excitatory amino acids concentration following morphine challenge in morphine-tolerant rats. Excitatory Amino Acids 30-52 colony stimulating factor 2 Rattus norvegicus 26-29 14750964-12 2004 Colocalization of SP and/or ENK with glutamate in boutons in the pre-BotC implies the combined synaptic release of excitatory amino acid and neuropeptides, which may exert combined post-synaptic effects onto NK1R-ir neurons and contribute to respiratory activity. Excitatory Amino Acids 115-136 proenkephalin Rattus norvegicus 28-31 14750964-12 2004 Colocalization of SP and/or ENK with glutamate in boutons in the pre-BotC implies the combined synaptic release of excitatory amino acid and neuropeptides, which may exert combined post-synaptic effects onto NK1R-ir neurons and contribute to respiratory activity. Excitatory Amino Acids 115-136 tachykinin receptor 1 Rattus norvegicus 208-212 14573382-1 2003 Group-III metabotropic glutamate receptors (mGluR4, -6, -7, and -8) modulate neurotoxicity of excitatory amino acids and beta-amyloid-peptide (betaAP), as well as epileptic convulsions, most likely via presynaptic inhibition of glutamatergic neurotransmission. Excitatory Amino Acids 94-116 glutamate receptor, ionotropic, AMPA4 (alpha 4) Mus musculus 44-50 12391608-4 2002 Furthermore, [D-Ser(26)]A beta1-40 in vivo, produced a drastic and synergistic neuronal loss by enhancing the excitotoxicity when co-injected into rat hippocampus with ibotenic acid, an excitatory amino acid, suggesting an in vivo conversion of non-toxic [D-Ser(26)]A beta1-40 to toxic fragments including [D-Ser(26)]A beta 25-35/40. Excitatory Amino Acids 186-207 AA1 Homo sapiens 24-31 12545331-4 2003 OBJECTIVES: To determine whether electrical or excitatory amino-acid stimulation of the BLC is sufficient to induce reinstatement of cocaine seeking in rats. Excitatory Amino Acids 47-68 C-X-C motif chemokine ligand 13 Homo sapiens 88-91 12681536-1 2003 BACKGROUND: The protective effect of excitatory amino acid antagonists for CA3 hippocampal neuronal loss has been well documentated. Excitatory Amino Acids 37-58 carbonic anhydrase 3 Rattus norvegicus 75-78 12419818-1 2003 Glutamate transport by the neuronal excitatory amino acid carrier (EAAC1) is accompanied by the coupled movement of one proton across the membrane. Excitatory Amino Acids 36-57 solute carrier family 1 member 1 Homo sapiens 67-72 12716406-0 2003 Lipopolysaccharide inhibits luteinizing hormone release through interaction with opioid and excitatory amino acid inputs to gonadotropin-releasing hormone neurones in female rats: possible evidence for a common mechanism involved in infection and immobilization stress. Excitatory Amino Acids 92-113 gonadotropin releasing hormone 1 Rattus norvegicus 124-154 12598620-0 2003 P2X7 receptor-mediated release of excitatory amino acids from astrocytes. Excitatory Amino Acids 34-56 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 0-13 12598620-3 2003 Here we show that P2X7 receptors provide a route for excitatory amino acid release from astrocytes. Excitatory Amino Acids 53-74 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 18-22 12535160-0 2003 Vasopressin and oxytocin decrease excitatory amino acid release in adult rat supraoptic nucleus. Excitatory Amino Acids 34-55 arginine vasopressin Rattus norvegicus 0-11 12535160-9 2003 These findings suggest that locally released oxytocin and vasopressin may autoregulate SON magnocellular neuroendocrine cell activity in part by modulating the release of excitatory amino acids from afferent terminals targeting these cells and/or from other cellular sources. Excitatory Amino Acids 171-193 arginine vasopressin Rattus norvegicus 58-69 11896170-0 2002 Episodic bursting activity and response to excitatory amino acids in acutely dissociated gonadotropin-releasing hormone neurons genetically targeted with green fluorescent protein. Excitatory Amino Acids 43-65 gonadotropin releasing hormone 1 Mus musculus 89-119 12061506-5 2002 Recent data show that neuronal IL-6 expression is induced by excitatory amino acids or membrane depolarization. Excitatory Amino Acids 61-83 interleukin 6 Homo sapiens 31-35 12042097-7 2002 COX2 induction peaked at toxic concentrations of these excitatory amino acids. Excitatory Amino Acids 55-77 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-4 12382430-2 2002 However, the current evidence shows that the primary role of BNPI is to accumulate excitatory amino acid neurotransmitter glutamate into synaptic vesicles as a vesicular transporter. Excitatory Amino Acids 83-104 solute carrier family 17 member 7 Rattus norvegicus 61-65 12144044-2 2002 In this study, we used post-embedding immunogold labelling to determine whether calbindin terminals in the IML contained the excitatory amino acid neurotransmitter glutamate. Excitatory Amino Acids 125-146 calbindin 1 Rattus norvegicus 80-89 11922665-0 2002 Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatum. Excitatory Amino Acids 0-22 glial cell derived neurotrophic factor Rattus norvegicus 65-69 11922665-0 2002 Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatum. Excitatory Amino Acids 0-22 neurturin Rattus norvegicus 71-80 12373514-1 2002 Previous work from our laboratory has suggested the functional contribution of p53 to the cascade of events triggered by excitatory amino acids and leading to cell death in primary neurons. Excitatory Amino Acids 121-143 tumor protein p53 Homo sapiens 79-82 11790511-6 2002 Stress-induced increase in both TACE activity and TNF-alpha levels seems to be mediated by excitatory amino acids since they can be blocked by MK-801 (dizocilpine) (0.2 mg/kg i.p. Excitatory Amino Acids 91-113 ADAM metallopeptidase domain 17 Rattus norvegicus 32-36 11790511-6 2002 Stress-induced increase in both TACE activity and TNF-alpha levels seems to be mediated by excitatory amino acids since they can be blocked by MK-801 (dizocilpine) (0.2 mg/kg i.p. Excitatory Amino Acids 91-113 tumor necrosis factor Rattus norvegicus 50-59 11928725-5 2002 These results raise the possibility that neurotoxicity of A beta is exacerbated by the enhancement of susceptibility to excitatory amino acids. Excitatory Amino Acids 120-142 amyloid beta precursor protein Rattus norvegicus 58-64 11437084-6 2001 Under noninjury conditions, vasopressin (40 pg/mL) coadministered with NMDA (10(-8), 10(-6) M) attenuated pial dilation to this excitatory amino acid (9 +/- 1% and 16 +/- 1% vs. 3 +/- 1% and 5 +/- 2%). Excitatory Amino Acids 128-149 vasopressin Sus scrofa 28-39 11852976-3 2002 Of these three groups, group I (mGluR1 and mGluR5) activation can initiate a number of intracellular pathways that lead to increased extracellular EAA concentrations. Excitatory Amino Acids 147-150 glutamate metabotropic receptor 1 Rattus norvegicus 32-38 11852976-3 2002 Of these three groups, group I (mGluR1 and mGluR5) activation can initiate a number of intracellular pathways that lead to increased extracellular EAA concentrations. Excitatory Amino Acids 147-150 glutamate receptor, ionotropic, kainate 1 Mus musculus 43-49 12622404-6 2002 Wild-type PTEN promoted, while dominant-negative PTEN prevented, apoptotic death of neurons exposed to the excitatory amino acid neurotransmitter glutamate. Excitatory Amino Acids 107-128 phosphatase and tensin homolog Mus musculus 10-14 12622404-6 2002 Wild-type PTEN promoted, while dominant-negative PTEN prevented, apoptotic death of neurons exposed to the excitatory amino acid neurotransmitter glutamate. Excitatory Amino Acids 107-128 phosphatase and tensin homolog Mus musculus 49-53 12065920-8 2002 With the onset of puberty, the disinhibition and reactivation of the LHRH pulse generator is associated with a fall in GABAergic neurotransmission and a concomitant increase in the input of excitatory amino acid neurotransmitters (including glutamate) and possibly astroglial-derived growth factors. Excitatory Amino Acids 190-211 gonadotropin releasing hormone 1 Homo sapiens 69-73 11458540-3 2001 This article reviews the effects of psychostimulant administration on dopaminergic and excitatory amino acid neurotransmission in brain regions comprising the brain"s motive circuit and provides evidence that the activation of endogenous kappa-opioid receptor systems in these regions opposes the behavioral and neurochemical consequences of repeated drug use. Excitatory Amino Acids 87-108 opioid receptor kappa 1 Homo sapiens 238-259 11382805-0 2001 Early intermediates in the transport cycle of the neuronal excitatory amino acid carrier EAAC1. Excitatory Amino Acids 59-80 solute carrier family 1 member 1 Homo sapiens 89-94 11259509-0 2001 Effects of glutathione depletion by 2-cyclohexen-1-one on excitatory amino acids-induced enhancement of activator protein-1 DNA binding in murine hippocampus. Excitatory Amino Acids 58-80 jun proto-oncogene Mus musculus 104-123 11172927-1 2001 To study interactions between estrogen and excitatory amino acid, changes in the mRNA level of the N-methyl-D-aspartate R2B subunit (NR2B) in the hypothalamus and hippocampus were measured following estrogen treatment in prepubertal female rats. Excitatory Amino Acids 43-64 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 133-137 11259509-1 2001 We have investigated the role of glutathione in mechanisms associated with excitatory amino acid signaling to the nuclear transcription factor activator protein-1 (AP1) in the brain using mice depleted of endogenous glutathione by prior treatment with 2-cyclohexen-1-one (CHX). Excitatory Amino Acids 75-96 jun proto-oncogene Mus musculus 143-162 11259509-1 2001 We have investigated the role of glutathione in mechanisms associated with excitatory amino acid signaling to the nuclear transcription factor activator protein-1 (AP1) in the brain using mice depleted of endogenous glutathione by prior treatment with 2-cyclohexen-1-one (CHX). Excitatory Amino Acids 75-96 jun proto-oncogene Mus musculus 164-167 11421488-4 2001 Since excitotoxicity of excitatory amino acids (EAAs) in the CNS is intimately associated with the GluRs, the toxic effects may be more generalized than initially assumed. Excitatory Amino Acids 24-46 glutamyl-tRNA synthetase 2, mitochondrial Homo sapiens 99-104 11421488-4 2001 Since excitotoxicity of excitatory amino acids (EAAs) in the CNS is intimately associated with the GluRs, the toxic effects may be more generalized than initially assumed. Excitatory Amino Acids 48-52 glutamyl-tRNA synthetase 2, mitochondrial Homo sapiens 99-104 11150350-2 2001 In rats, stress-induced changes in CA3 apical dendritic structure are mediated by corticosterone (CORT) acting, in part, on excitatory amino acid neurotransmission. Excitatory Amino Acids 124-145 carbonic anhydrase 3 Rattus norvegicus 35-38 11275665-2 2001 A substantial part of PHI-related brain damage occurs upon reperfusion and reoxygenation by the excess production of excitatory amino acids, free (pro)radicals and the release of cytokines, triggering programmed cell death. Excitatory Amino Acids 117-139 glucose-6-phosphate isomerase Homo sapiens 22-25 11145617-9 2001 Additionally, the close association between glucose utilization and excitatory amino acid activity suggests that IGF-1 may act on specific neural pathways to increase glutamate activity in brain regions associated with learning and memory. Excitatory Amino Acids 68-89 insulin-like growth factor 1 Rattus norvegicus 113-118 11150327-7 2001 Both excitatory amino acids increased BDNF expression in neurons of cortical layers II/III, V, and VI that project to the striatum. Excitatory Amino Acids 5-27 brain derived neurotrophic factor Homo sapiens 38-42 11150350-2 2001 In rats, stress-induced changes in CA3 apical dendritic structure are mediated by corticosterone (CORT) acting, in part, on excitatory amino acid neurotransmission. Excitatory Amino Acids 124-145 cortistatin Rattus norvegicus 98-102 11019904-0 2000 Interrelationships of GABAergic, serotoninergic and excitatory amino acid systems in its regulatory effect on prolactin secretion in prepubertal rats. Excitatory Amino Acids 52-73 prolactin Rattus norvegicus 110-119 11208916-10 2001 Taken together, these findings indicate that excitatory amino acids and subsequent activation of NF-kappaB account for stress-induced iNOS expression in cerebral cortex, and support a possible neuroprotective role for specific inhibitors in this situation. Excitatory Amino Acids 45-67 nitric oxide synthase 2 Rattus norvegicus 134-138 11179596-6 2001 Under non injury conditions, ET-1 (10(-10) M) coadministered with NMDA attenuated pial dilation to this excitatory amino acid. Excitatory Amino Acids 104-125 endothelin-1 Sus scrofa 29-33 11012837-0 2000 The effects of ionotropic agonists of excitatory amino acids on the release of arginine vasopressin in rat hypothalamic slices. Excitatory Amino Acids 38-60 arginine vasopressin Rattus norvegicus 88-99 11012837-11 2000 These findings demonstrate that ionotropic excitatory amino acids agonists inhibit vasopressin secretion from hypothalamic slices. Excitatory Amino Acids 43-65 arginine vasopressin Rattus norvegicus 83-94 11144959-2 2000 The growth factors basic fibroblast growth factor (FGF-2), nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) improve survival and promote differentiation of striatal neurons, as well as exert a neuroprotective effect when such neurons are challenged with metabolic toxins or excitatory amino acids. Excitatory Amino Acids 297-319 fibroblast growth factor 2 Homo sapiens 51-56 11144959-2 2000 The growth factors basic fibroblast growth factor (FGF-2), nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) improve survival and promote differentiation of striatal neurons, as well as exert a neuroprotective effect when such neurons are challenged with metabolic toxins or excitatory amino acids. Excitatory Amino Acids 297-319 brain derived neurotrophic factor Homo sapiens 90-123 11144959-2 2000 The growth factors basic fibroblast growth factor (FGF-2), nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) improve survival and promote differentiation of striatal neurons, as well as exert a neuroprotective effect when such neurons are challenged with metabolic toxins or excitatory amino acids. Excitatory Amino Acids 297-319 brain derived neurotrophic factor Homo sapiens 125-129 11208916-7 2001 Since glutamate release and subsequent NMDA (N-methyl-D-aspartate) receptor activation has been recognized as an early change after exposure to stressful stimuli, and glutamate has been shown to induce iNOS in brain via a NF-kappaB-dependent mechanism, we studied the possible role of excitatory amino acids in the induction of iNOS in our model. Excitatory Amino Acids 285-307 nitric oxide synthase 2 Rattus norvegicus 202-206 11107163-1 2000 In the adult cerebellum, corticotropin releasing factor (CRF), that is localized in climbing fibers, mossy fibers, and a fine varicose plexus along the Purkinje cell layer, modulates the responsiveness of Purkinje cells to excitatory amino acids. Excitatory Amino Acids 223-245 corticotropin releasing hormone Mus musculus 25-55 11122374-7 2000 These results demonstrate that tonic activation of glutamate-gated cation channels downregulates neuronal expression of the TGFbeta2 gene and provide evidence for a novel mechanism whereby excitatory amino acids could influence the development of glial and neuronal lineages. Excitatory Amino Acids 189-211 transforming growth factor, beta 2 Rattus norvegicus 124-132 15758524-7 2000 EAA supplements were associated with stimulated bone formation and reduced bone resorption, with increment of plasma IGF-I and of limb muscle mass weight. Excitatory Amino Acids 0-3 insulin-like growth factor 1 Rattus norvegicus 117-122 11019904-1 2000 GABAergic, serotoninergic and excitatory amino acid systems (EAAs) regulate the prolactin (PROL) secretion in prepubertal female rats. Excitatory Amino Acids 30-51 prolactin Rattus norvegicus 80-89 11019904-1 2000 GABAergic, serotoninergic and excitatory amino acid systems (EAAs) regulate the prolactin (PROL) secretion in prepubertal female rats. Excitatory Amino Acids 30-51 prolactin Rattus norvegicus 91-95 10800947-11 2000 To our knowledge, this is the first report showing an implication of excitatory amino acids in the expression of iNOS caused by ischemia. Excitatory Amino Acids 69-91 nitric oxide synthase 2 Rattus norvegicus 113-117 10901443-2 2000 In the hypothalamus, EAA/NMDAR interaction triggers the activation of neuronal nitric oxide synthase (nNOS) to produce nitric oxide (NO). Excitatory Amino Acids 21-24 nitric oxide synthase 1 Homo sapiens 70-100 10901443-2 2000 In the hypothalamus, EAA/NMDAR interaction triggers the activation of neuronal nitric oxide synthase (nNOS) to produce nitric oxide (NO). Excitatory Amino Acids 21-24 nitric oxide synthase 1 Homo sapiens 102-106 10958523-3 2000 The glial transporters glutamate-aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1), and the neuronal transporter excitatory amino acids carrier-1 (EAAC-1) limit excitation initiated by synaptic release of glutamate. Excitatory Amino Acids 129-151 solute carrier family 1 member 1 Rattus norvegicus 163-169 10677552-8 2000 N-Methyl-d-aspartic acid (NMDA), which mimics the action of the excitatory amino acid neurotransmitter glutamic acid, releases LH-RH by releasing NO. Excitatory Amino Acids 64-85 gonadotropin releasing hormone 1 Homo sapiens 127-132 10773201-0 2000 Transporter-mediated GABA release induced by excitatory amino acid agonist is associated with GAD-67 but not GAD-65 immunoreactive cells of the primate retina. Excitatory Amino Acids 45-66 glutamate decarboxylase 1 Homo sapiens 94-100 10795920-8 2000 Thus, steroid inhibition of osmotically stimulated vasopressin secretion may reflect inhibition of mechanisms mediated by excitatory amino acids. Excitatory Amino Acids 122-144 arginine vasopressin Rattus norvegicus 51-62 10901626-0 2000 Excitatory amino acid stimulation of the survival of rat cerebellar granule cells in culture is associated with an increase in SMN, the spinal muscular atrophy disease gene product. Excitatory Amino Acids 0-21 survival of motor neuron 1, telomeric Rattus norvegicus 127-130 10901626-1 2000 Excitatory amino acids which promote the survival of cerebellar granule cells in culture, also promote the expression of the survival of motor neuron (SMN) protein. Excitatory Amino Acids 0-22 survival of motor neuron 1, telomeric Rattus norvegicus 125-149 11026497-5 2000 Our data suggest that nanomolar concentrations of TEF may reduce excitatory aminoacid release following neuronal depolarization via a presynaptic mechanism involving voltage sensitive sodium channels, and therefore may be considered as a prototype for therapeutic drugs in the treatment of diseases that involve excitatory aminoacid neurotransmission. Excitatory Amino Acids 65-85 TEF transcription factor, PAR bZIP family member Homo sapiens 50-53 10901626-1 2000 Excitatory amino acids which promote the survival of cerebellar granule cells in culture, also promote the expression of the survival of motor neuron (SMN) protein. Excitatory Amino Acids 0-22 survival of motor neuron 1, telomeric Rattus norvegicus 151-154 10526139-10 1999 Furthermore, in the experiment using the styryl dye FM1-43, which selectively labels synaptic vesicles, neither BDNF nor NGF evoked dye loss, suggesting that neurotrophin-induced excitatory amino acid release occurs through a non-exocytotic pathway. Excitatory Amino Acids 179-200 brain derived neurotrophic factor Homo sapiens 158-170 10523758-8 1999 These data (1) raise an important issue regarding the origin of the terminals forming asymmetrical synapses in the striatum, (2) suggest that adaptative changes in the neuropeptide Y neuronal network may be a main component of striatal remodelling resulting from the progressive loss of cortical inputs, and (3) reinforce the view that neuropeptide Y and excitatory amino acid functions may be tightly linked in the striatum. Excitatory Amino Acids 355-376 neuropeptide Y Rattus norvegicus 168-182 10561426-0 1999 Evidence for endogenous excitatory amino acids as mediators in DSI of GABA(A)ergic transmission in hippocampal CA1. Excitatory Amino Acids 24-46 carbonic anhydrase 1 Homo sapiens 111-114 10999545-7 2000 CONCLUSION: Excessive excitatory amino acid-mediated synaptic driving may lead to a hyperexcitable condition that is responsible for the epileptic manifestations occurring in Otx1-/- mice. Excitatory Amino Acids 22-43 orthodenticle homeobox 1 Mus musculus 175-179 10668104-1 1999 Our previous studies indicating that the function of excitatory amino acids, NMDA type receptor, is modulated by serotonin focused on the interaction between serotonin 5HT1B/1D and glutamate, NMDA receptor in brain cortex. Excitatory Amino Acids 53-75 5-hydroxytryptamine receptor 1B Rattus norvegicus 168-173 10581082-5 1999 These data indicate that NAALADase inhibition may have use in neurological disorders in which excessive excitatory amino acid transmission is pathogenic. Excitatory Amino Acids 104-125 folate hydrolase 1 Rattus norvegicus 25-34 10320673-3 1999 Brain ischemia triggers a cascade of events, possibly mediated by excitatory amino acids, yielding the activation of the Ca2+-dependent NOS isoforms, i.e. neuronal NOS (nNOS) and endothelial NOS (eNOS). Excitatory Amino Acids 66-88 nitric oxide synthase 1 Homo sapiens 155-167 10501550-5 1999 These results indicate that GLP-1 receptors exist in the hippocampus and are involved in modulating hippocampal activity through an increase in the release of excitatory amino acid transmitters. Excitatory Amino Acids 159-180 glucagon Rattus norvegicus 28-33 10487857-5 1999 This model system will allow the systematic examination of the role of COX-2 in mechanisms of neurodegeneration that involve excitatory amino acid pathways. Excitatory Amino Acids 125-146 cytochrome c oxidase II, mitochondrial Mus musculus 71-76 10622402-1 1999 The objectives of this study were to determine whether stress attenuates the pituitary LH response to excitatory amino acids by altering expression of glutamate receptor 1 (GluR1) and N-methyl-D-aspartic acid (NMDA) receptor mRNA levels in the hypothalamus or pituitary, and assess whether stress influences testicular levels of mRNA or protein for steroidogenic enzymes. Excitatory Amino Acids 102-124 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 151-171 10622402-1 1999 The objectives of this study were to determine whether stress attenuates the pituitary LH response to excitatory amino acids by altering expression of glutamate receptor 1 (GluR1) and N-methyl-D-aspartic acid (NMDA) receptor mRNA levels in the hypothalamus or pituitary, and assess whether stress influences testicular levels of mRNA or protein for steroidogenic enzymes. Excitatory Amino Acids 102-124 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 173-178 10428021-1 1999 In our laboratory, the positive influence of angiotensin II and its 3-7 fragment on learning and memory processes was found to be mediated by excitatory amino acids, because it was abolished by N-methyl-D-aspartate (NMDA) receptor antagonists. Excitatory Amino Acids 142-164 angiotensinogen Rattus norvegicus 45-59 10378991-1 1999 It has been found in our laboratory that the positive influence of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on learning and memory processes is mediated by the excitatory amino acids, since it was abolished by NMDA receptor antagonists. Excitatory Amino Acids 172-194 angiotensinogen Rattus norvegicus 67-81 10378991-1 1999 It has been found in our laboratory that the positive influence of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on learning and memory processes is mediated by the excitatory amino acids, since it was abolished by NMDA receptor antagonists. Excitatory Amino Acids 172-194 angiotensinogen Rattus norvegicus 83-86 10378991-1 1999 It has been found in our laboratory that the positive influence of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on learning and memory processes is mediated by the excitatory amino acids, since it was abolished by NMDA receptor antagonists. Excitatory Amino Acids 172-194 angiotensinogen Rattus norvegicus 110-113 10350539-3 1999 We found that bilateral injection of nociceptin (10 nmol) into the rostral ventrolateral medulla (RVLM), wherein injection of excitatory amino acid dl-homocysteic acid (3 nmol) induced typical pressor responses, significantly reduced arterial blood pressure and heart rate by -32% and -15%, respectively. Excitatory Amino Acids 126-147 prepronociceptin Rattus norvegicus 37-47 10320673-3 1999 Brain ischemia triggers a cascade of events, possibly mediated by excitatory amino acids, yielding the activation of the Ca2+-dependent NOS isoforms, i.e. neuronal NOS (nNOS) and endothelial NOS (eNOS). Excitatory Amino Acids 66-88 nitric oxide synthase 1 Homo sapiens 169-173 10320673-3 1999 Brain ischemia triggers a cascade of events, possibly mediated by excitatory amino acids, yielding the activation of the Ca2+-dependent NOS isoforms, i.e. neuronal NOS (nNOS) and endothelial NOS (eNOS). Excitatory Amino Acids 66-88 nitric oxide synthase 3 Homo sapiens 179-194 10319794-12 1999 CONCLUSIONS: Propofol prevents and reverses the inhibition of excitatory amino acid uptake in astrocytes exposed to tert-butyl hydroperoxide. Excitatory Amino Acids 62-83 telomerase reverse transcriptase Rattus norvegicus 116-120 10323261-0 1999 Neuroprotective effect of thyrotropin-releasing hormone against excitatory amino acid-induced cell death in hippocampal slices. Excitatory Amino Acids 64-85 thyrotropin releasing hormone Homo sapiens 26-55 10209245-3 1999 In the presence of TTX (10 microM) and excitatory amino acid antagonists, AP5 (50 microM) and CNQX (50 microM), we whole-cell recorded mIPSCs in CA3 cells of hippocampal slices of adult and young (4-8 days) rats. Excitatory Amino Acids 39-60 carbonic anhydrase 3 Rattus norvegicus 145-148 15539275-5 1999 Serum insulin increased from normal physiologic levels at baseline (9.2 +/- 0.8 microU/mL) and peaked (48 +/- 7.1 microU/mL) 30 minutes after EAA ingestion. Excitatory Amino Acids 142-145 insulin Homo sapiens 6-13 10837719-4 1999 The brain delivery system has been optimized and it was demonstrated that the brain delivery of three drugs, a drug for Parkinson"s disease, an excitatory amino acid antagonist and a free radical scavenger, were improved by the conjugation with cis-2-formylaminoethenylthio derivatives in vivo. Excitatory Amino Acids 144-165 suppressor of cytokine signaling 2 Homo sapiens 245-250 9952413-10 1999 Broad spectrum excitatory amino acid antagonists (kyurenic acid) or selective antagonists of the NMDA receptor (APV) both prevent induction of TH expression in OE-OB cocultures. Excitatory Amino Acids 15-36 tyrosine hydroxylase Rattus norvegicus 143-145 10095166-1 1999 To assess whether fetal luteinizing hormone releasing hormone (LH-RH) neurosecretory neurons have the capacity to respond to an exogenous stimulus, a synthetic excitatory amino acid analogue, N-methyl-D-L-aspartate (NMDA; 15 mg/kg), was given rapidly intravenously to 8 chronically catheterized fetuses (130-142 days of gestation; term 147 +/- 3 days). Excitatory Amino Acids 160-181 gonadotropin releasing hormone 1 Homo sapiens 24-61 10027541-7 1999 This study suggests that excitatory amino acids, e.g. glutamate but not the inhibitory aminos acid, glycine, plays a role in thermal nociception which in turn is mediated, in part, by c-fos activity. Excitatory Amino Acids 25-47 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 184-189 10095166-1 1999 To assess whether fetal luteinizing hormone releasing hormone (LH-RH) neurosecretory neurons have the capacity to respond to an exogenous stimulus, a synthetic excitatory amino acid analogue, N-methyl-D-L-aspartate (NMDA; 15 mg/kg), was given rapidly intravenously to 8 chronically catheterized fetuses (130-142 days of gestation; term 147 +/- 3 days). Excitatory Amino Acids 160-181 gonadotropin releasing hormone 1 Homo sapiens 63-68 10666669-6 1999 Deteriorated c-fos expression in the individual brain regions may be linked to increased apoptosis and neurodegeneration, overexcitation by excitatory amino acids of reactive oxygen species. Excitatory Amino Acids 140-162 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 13-18 10631596-0 1999 The role of NO and B-50 in neurotoxicity of excitatory amino acids. Excitatory Amino Acids 44-66 growth associated protein 43 Homo sapiens 19-23 9843643-0 1998 Excitatory amino acids act on the median eminence nerve terminals to induce gonadotropin-releasing hormone release in female rats. Excitatory Amino Acids 0-22 gonadotropin releasing hormone 1 Rattus norvegicus 76-106 10465454-0 1999 Orphanin FQ (nociceptin) modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli, and blocks the substance P-induced facilitation of N-methyl-D-aspartate-evoked responses. Excitatory Amino Acids 77-99 prepronociceptin Rattus norvegicus 0-11 10465454-0 1999 Orphanin FQ (nociceptin) modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli, and blocks the substance P-induced facilitation of N-methyl-D-aspartate-evoked responses. Excitatory Amino Acids 77-99 prepronociceptin Rattus norvegicus 13-23 10465454-1 1999 The present investigation details the modulation of medullary dorsal horn neuron responses to excitatory amino acids and peripheral cutaneous stimuli by orphanin FQ (nociceptin), an endogenous ligand for the opioid receptor-like, receptor. Excitatory Amino Acids 94-116 prepronociceptin Rattus norvegicus 153-164 10465454-1 1999 The present investigation details the modulation of medullary dorsal horn neuron responses to excitatory amino acids and peripheral cutaneous stimuli by orphanin FQ (nociceptin), an endogenous ligand for the opioid receptor-like, receptor. Excitatory Amino Acids 94-116 prepronociceptin Rattus norvegicus 166-176 10465454-10 1999 In order to compare electrophysiological data with previous behavioral observations, effects of orphanin FQ administered intracerebroventricularly were tested on the excitatory amino acid-evoked responses. Excitatory Amino Acids 166-187 prepronociceptin Rattus norvegicus 96-107 10336072-4 1999 These results suggest an interaction between glucocorticoids and excitatory amino acids in the development of stress-induced atrophy of CA3 pyramidal neurons. Excitatory Amino Acids 65-87 carbonic anhydrase 3 Rattus norvegicus 136-139 10051378-1 1999 It has been found in our laboratory that the positive influence of vasopressin (AVP) on memory processes is mediated by excitatory amino acids, since it was abolished by NMDA receptor antagonists. Excitatory Amino Acids 120-142 arginine vasopressin Rattus norvegicus 67-78 9843643-1 1998 The present study is designed to examine the terminal regulation of gonadotropin-releasing hormone (GnRH) release by excitatory amino acids in the median eminence of ovariectomized (OVX) rats. Excitatory Amino Acids 117-139 gonadotropin releasing hormone 1 Rattus norvegicus 68-98 9843643-1 1998 The present study is designed to examine the terminal regulation of gonadotropin-releasing hormone (GnRH) release by excitatory amino acids in the median eminence of ovariectomized (OVX) rats. Excitatory Amino Acids 117-139 gonadotropin releasing hormone 1 Rattus norvegicus 100-104 9843643-8 1998 The present results indicate that excitatory amino acids stimulate GnRH release by acting at the nerve terminals of the median eminence in a Ca2+-dependent manner in the absence of gonadal steroid. Excitatory Amino Acids 34-56 gonadotropin releasing hormone 1 Rattus norvegicus 67-71 9813252-8 1998 Treatment with the ATP-receptor antagonist, suramin, had a minimal effect on the response in the presence of EAA antagonists. Excitatory Amino Acids 109-112 purinergic receptor P2X 7 Rattus norvegicus 19-31 10069697-7 1998 These data indicate that excitatory amino acids are involved in the mechanism of increase in blood vasopressin and cardiodepressant factor concentration in response to osmotic stimulation. Excitatory Amino Acids 25-47 arginine vasopressin Rattus norvegicus 99-110 9851655-0 1998 Motor neurone acetylcholinesterase release precedes neurotoxicity caused by systemic administration of excitatory amino acids and strychnine. Excitatory Amino Acids 103-125 acetylcholinesterase Mus musculus 14-34 9802040-6 1998 This area, specially sensitive to hypoxia-ischemia, offers an excellent study option for focal, experimental, cerebral ischemia associated with toxicity mediated by excitatory amino acids, since it stores an important concentration of NMDA receptors (R1/R2 A) as well as endothelial nitric oxide synthase. Excitatory Amino Acids 165-187 ribonuclease A family member 3 Rattus norvegicus 251-258 10190140-0 1998 [Amyloidogenic peptides such as beta-amyloid, amylin and calcitonin strongly enhance the susceptibility of rat hippocampal neurons to excitatory amino acids in vivo]. Excitatory Amino Acids 134-156 islet amyloid polypeptide Rattus norvegicus 46-52 9739154-0 1998 Nicotinic acetylcholine receptor mediated modulation of evoked excitatory amino acid release in the nucleus tractus solitarius of the rat: evidence from in vivo microdialysis. Excitatory Amino Acids 63-84 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 0-32 9744485-1 1998 Previous experiments demonstrated that excitatory amino acids participate in the osmotic regulation of vasopressin secretion, but the specific involvement of N-methyl-D-aspartic acid (NMDA) receptors was not evaluated. Excitatory Amino Acids 39-61 arginine vasopressin Homo sapiens 103-114 9628758-1 1998 We have recently established a rat substantia nigra (SN) slice preparation in which a sensitive index of excitatory amino acid (EAA) toxicity was degeneration of the dendritic arbor of catecholamine neurons labelled by immunostaining for tyrosine hydroxylase (TH). Excitatory Amino Acids 105-126 tyrosine hydroxylase Rattus norvegicus 238-258 9666148-0 1998 Increased spinal release of excitatory amino acids following intradermal injection of capsaicin is reduced by a protein kinase G inhibitor. Excitatory Amino Acids 28-50 protein kinase cGMP-dependent 1 Homo sapiens 112-128 9628758-1 1998 We have recently established a rat substantia nigra (SN) slice preparation in which a sensitive index of excitatory amino acid (EAA) toxicity was degeneration of the dendritic arbor of catecholamine neurons labelled by immunostaining for tyrosine hydroxylase (TH). Excitatory Amino Acids 128-131 tyrosine hydroxylase Rattus norvegicus 238-258 9547227-8 1998 These data indicate that coupling of Ca2+ to activation of AC1 is crucial for mossy fiber LTP, most likely via activation of PKA and enhancement of excitatory amino acid secretion. Excitatory Amino Acids 148-169 adenylate cyclase 1 Mus musculus 59-62 9572271-7 1998 Cotreatment with kappaB decoy DNA abolished the effects of TNF alpha on Ca2+ current and excitatory amino acid-induced currents, demonstrating a requirement for NF-kappaB activation in the actions of TNF alpha. Excitatory Amino Acids 89-110 tumor necrosis factor Rattus norvegicus 59-68 9572271-7 1998 Cotreatment with kappaB decoy DNA abolished the effects of TNF alpha on Ca2+ current and excitatory amino acid-induced currents, demonstrating a requirement for NF-kappaB activation in the actions of TNF alpha. Excitatory Amino Acids 89-110 tumor necrosis factor Rattus norvegicus 200-209 9572271-8 1998 Neurons pretreated with TNF alpha exhibited increased intracellular Ca2+ concentrations following membrane depolarization but reduced intracellular Ca2+ concentration responses to excitatory amino acids, compared with neurons in untreated control cultures or cultures cotreated with kappaB decoy DNA. Excitatory Amino Acids 180-202 tumor necrosis factor Rattus norvegicus 24-33 9483558-7 1998 These results demonstrate that exogenously supplied brain-derived neurotrophic factor can prevent delayed, transneuronal loss, and implicate decreased excitatory amino acid transmission or diminished nigral neuron susceptibility to glutamate inputs in the protective effect of brain-derived neurotrophic factor. Excitatory Amino Acids 151-172 brain-derived neurotrophic factor Rattus norvegicus 52-85 9650803-0 1998 Role of vasopressin on excitatory amino acids mediated pressor responses in the periaqueductal gray area. Excitatory Amino Acids 23-45 arginine vasopressin Rattus norvegicus 8-19 9650803-9 1998 Our results document: i) the importance of the PAG area in the control of cardiovascular system; ii) the involvement of excitatory amino acids in the neural control of vasopressin release; iii) the close relationship between glutamate and vasopressin in the central blood pressure regulation. Excitatory Amino Acids 120-142 arginine vasopressin Rattus norvegicus 168-179 9542890-9 1998 Analysis of the type of axon terminals synapsing on EAAC1-ir profiles showed that 97% of them formed asymmetric contacts, thus indicating that EAAC1 is located at the very sites of excitatory amino acid release. Excitatory Amino Acids 181-202 solute carrier family 1 member 1 Rattus norvegicus 143-148 9596556-6 1998 These results suggest that the sigma1 receptor subtype plays an important role in the sigma receptor ligands-induced neuroprotective effects via the regulation of excitatory amino acids (EAAs) release from the presynaptic sites. Excitatory Amino Acids 163-185 sigma non-opioid intracellular receptor 1 Rattus norvegicus 31-46 9596556-6 1998 These results suggest that the sigma1 receptor subtype plays an important role in the sigma receptor ligands-induced neuroprotective effects via the regulation of excitatory amino acids (EAAs) release from the presynaptic sites. Excitatory Amino Acids 187-191 sigma non-opioid intracellular receptor 1 Rattus norvegicus 31-46 9492084-0 1998 Evidence for terminal regulation of GnRH release by excitatory amino acids in the median eminence in female rats: a dual immunoelectron microscopic study. Excitatory Amino Acids 52-74 gonadotropin releasing hormone 1 Rattus norvegicus 36-40 9465106-0 1998 Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Excitatory Amino Acids 91-112 sulfotransferase family 2A member 1 Homo sapiens 48-53 9492084-1 1998 The present study was designed to determine whether excitatory amino acids directly act on the gonadotropin-releasing hormone (GnRH) nerve terminals to release the peptide. Excitatory Amino Acids 52-74 gonadotropin releasing hormone 1 Rattus norvegicus 95-125 9492084-1 1998 The present study was designed to determine whether excitatory amino acids directly act on the gonadotropin-releasing hormone (GnRH) nerve terminals to release the peptide. Excitatory Amino Acids 52-74 gonadotropin releasing hormone 1 Rattus norvegicus 127-131 9492084-7 1998 These results suggest that GnRH release is regulated at the GnRH nerve terminals by excitatory amino acids in a non-synaptic manner in the median eminence. Excitatory Amino Acids 84-106 gonadotropin releasing hormone 1 Rattus norvegicus 27-31 9492084-7 1998 These results suggest that GnRH release is regulated at the GnRH nerve terminals by excitatory amino acids in a non-synaptic manner in the median eminence. Excitatory Amino Acids 84-106 gonadotropin releasing hormone 1 Rattus norvegicus 60-64 9577844-3 1998 We set out to test the hypothesis that involvement of IL-1 beta in neurodegeneration results in some interaction with excitatory amino acid-mediated synaptic transmission in the rat striatum, either by modifying glutamate release or actions. Excitatory Amino Acids 118-139 interleukin 1 beta Rattus norvegicus 54-63 9587916-5 1998 It is concluded that, during cyanide-induced ischemia, CORT might mainly the ability of astrocytes to clear excitatory amino acids from the synapse, thus exacerbating the damaging cascade of these amino acids. Excitatory Amino Acids 108-130 cortistatin Rattus norvegicus 55-59 9753133-0 1998 Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids. Excitatory Amino Acids 116-138 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 46-49 9753133-8 1998 Blockade of p53 induction by a specific p53 antisense oligonucleotide resulted in a partial reduction of excitotoxicity with a complete inhibition of the excitatory amino acids induced apoptosis. Excitatory Amino Acids 154-176 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 12-15 9753133-8 1998 Blockade of p53 induction by a specific p53 antisense oligonucleotide resulted in a partial reduction of excitotoxicity with a complete inhibition of the excitatory amino acids induced apoptosis. Excitatory Amino Acids 154-176 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 40-43 9372196-7 1997 These results indicate that the observed conductance increase associated with 5-HT application accounts for most if not all of the observed depressant effects of 5-HT1A agonists on excitatory amino acid-mediated neurotransmission. Excitatory Amino Acids 181-202 5-hydroxytryptamine receptor 1A Rattus norvegicus 162-168 10322749-3 1998 RESULTS: Indicated that exposure to CS2 could cause decrease in 3-methoxy-4-hydroxy mandelic acid (VMA), increase in 3,4-dioxybenzoic acid, a metabolite of dopamine, and high vanillic acid in rat straitum, decrease in excitatory amino acids and their metabolites (glutamine, aspartic acid and asparagine), with a certain relationship between contents of VMA, aspartic acid and asparagine and changes in neurobehavior. Excitatory Amino Acids 218-240 calsyntenin 2 Rattus norvegicus 36-39 9405958-9 1997 Because corticosterone- and stress-induced atrophy of CA3 dendrites is also blocked by phenytoin, an inhibitor of excitatory amino acid release and actions, these results suggest that serotonin released by stress or corticosterone may interact pre- or post-synaptically with glutamate released by stress or corticosterone, and that the final common path may involve interactive effects between serotonin and glutamate receptors on the dendrites of CA3 neurons innervated by mossy fibers from the dentate gyrus. Excitatory Amino Acids 114-135 carbonic anhydrase 3 Homo sapiens 54-57 9347948-0 1997 Cholecystokinin (CCK-8) modulates vesicular release of excitatory amino acids in rat hippocampal nerve endings. Excitatory Amino Acids 55-77 cholecystokinin Rattus norvegicus 0-15 9347948-0 1997 Cholecystokinin (CCK-8) modulates vesicular release of excitatory amino acids in rat hippocampal nerve endings. Excitatory Amino Acids 55-77 cholecystokinin Rattus norvegicus 17-20 9347948-6 1997 In conclusion, CCK stimulates exocytosis of excitatory amino acids in rat hippocampus by activating a low-affinity presynaptic CCK receptor, presumably of the B-subtype. Excitatory Amino Acids 44-66 cholecystokinin Rattus norvegicus 15-18 9347948-6 1997 In conclusion, CCK stimulates exocytosis of excitatory amino acids in rat hippocampus by activating a low-affinity presynaptic CCK receptor, presumably of the B-subtype. Excitatory Amino Acids 44-66 cholecystokinin Rattus norvegicus 127-130 9256122-0 1997 Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer. Excitatory Amino Acids 30-51 colony stimulating factor 2 Homo sapiens 77-80 9376532-1 1997 We investigated the dose-response and time-course of c-fos antisense oligodeoxynucleotide (ASO) treatment against excitatory amino acid (EAA)-induced neurotoxicity in rat hippocampal neurons. Excitatory Amino Acids 114-135 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 53-58 9376532-1 1997 We investigated the dose-response and time-course of c-fos antisense oligodeoxynucleotide (ASO) treatment against excitatory amino acid (EAA)-induced neurotoxicity in rat hippocampal neurons. Excitatory Amino Acids 137-140 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 53-58 9270899-0 1997 Upregulation of Calbindin-D-28k immunoreactivity by excitatory amino acids. Excitatory Amino Acids 52-74 calbindin 1 Homo sapiens 16-25 9270899-5 1997 It was found that at low temperature, PCs are very slightly immunoreactive and therefore the experiments were done at 22 degrees C. The results show that Calbindin-IR increases in PCs exposed to the neurotoxic agonists, Kainic acid (KA) and AMPA as well as to glutamate (Glu), the endogenous EAA. Excitatory Amino Acids 292-295 calbindin 1 Homo sapiens 154-163 9367259-5 1997 24 h pretreatment with either EGF or bFGF (500 pM each) prevented the majority of excitatory amino acid-induced neuronal death, whereas similar treatment with 10(-5) M GM1 did not block neuronal degeneration. Excitatory Amino Acids 82-103 epidermal growth factor Rattus norvegicus 30-33 9367259-5 1997 24 h pretreatment with either EGF or bFGF (500 pM each) prevented the majority of excitatory amino acid-induced neuronal death, whereas similar treatment with 10(-5) M GM1 did not block neuronal degeneration. Excitatory Amino Acids 82-103 fibroblast growth factor 2 Rattus norvegicus 37-41 9041361-3 1997 We investigated the possibility of a direct action of EAA on the secretion of the major adrenocorticotropin hormone (ACTH) secretagogue: corticotropin-releasing factor (CRF) from incubated rat hypothalamic slices. Excitatory Amino Acids 54-57 corticotropin releasing hormone Rattus norvegicus 137-167 9307136-12 1997 Although the present experiments do not elucidate mechanism(s) definitively, the afferent specificity, similarity to the effects of kainic acid, and block by K252a are consistent with previous hypotheses that BDNF affects acute excitability by a presynaptic action on trkB receptors that modulate excitatory amino acid transmission. Excitatory Amino Acids 297-318 brain-derived neurotrophic factor Rattus norvegicus 209-213 9210523-1 1997 The effect of excitatory amino acids (EAAs) on c-fos mRNA expression was studied in primary cultures of mouse cerebellar granule cells and in neocortical neurons after 2 and 7 days in vitro (div). Excitatory Amino Acids 14-36 FBJ osteosarcoma oncogene Mus musculus 47-52 9191105-0 1997 Induction of heat-shock protein (HSP72) in the cingulate and retrosplenial cortex by drugs that antagonize the effects of excitatory amino acids. Excitatory Amino Acids 122-144 selenoprotein K Rattus norvegicus 13-31 9191105-0 1997 Induction of heat-shock protein (HSP72) in the cingulate and retrosplenial cortex by drugs that antagonize the effects of excitatory amino acids. Excitatory Amino Acids 122-144 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 33-38 9224837-3 1997 The calcium-binding protein calbindin D-28k (CB) was exploited as a marker of neuronal subsets, thus allowing us to study also the relationships between the CB-containing neurons and those immunoreactive to excitatory amino acids. Excitatory Amino Acids 207-229 calbindin 1 Rattus norvegicus 28-37 9071469-15 1997 In this study, we describe for the first time, the expression of GLAST (and GLT-1) in bone, raising the possibility that excitatory amino acids may have a role in paracrine intercellular communication in bone. Excitatory Amino Acids 121-143 solute carrier family 1 member 3 Rattus norvegicus 65-70 9071469-15 1997 In this study, we describe for the first time, the expression of GLAST (and GLT-1) in bone, raising the possibility that excitatory amino acids may have a role in paracrine intercellular communication in bone. Excitatory Amino Acids 121-143 solute carrier family 1 member 2 Rattus norvegicus 76-81 9357063-0 1997 Effect of excitatory amino acids on rat hypothalamic somatostatin secretion in vitro. Excitatory Amino Acids 10-32 somatostatin Rattus norvegicus 53-65 9363843-13 1997 The hepatic GST activity toward EAA was unaltered, significantly increased and decreased in 20-, 90- and 360-day-old rats, respectively. Excitatory Amino Acids 32-35 hematopoietic prostaglandin D synthase Rattus norvegicus 12-15 9030417-11 1997 Indeed, because the GnRH neurons of the rhesus macaque are located diffusely in various regions of the hypothalamus and medial-septal/preoptic area, their net response to excitatory amino acids is likely to be more complicated, involving a combination of both stimulatory and inhibitory inter-neurons, and possibly also a direct interaction. Excitatory Amino Acids 171-193 gonadotropin releasing hormone 1 Macaca mulatta 20-24 8982682-4 1996 These results suggest that excitatory amino acids may be involved in the cGMP formation caused by TRH in the cerebellar areas, and that cGMP formation is inhibited by enhancement of GABAA receptor function. Excitatory Amino Acids 27-49 thyrotropin releasing hormone Rattus norvegicus 98-101 8973819-1 1996 In order to evaluate if the changes of the hypothalamic-pituitary-ovary axis that induce a decrease in fertility and modifications in the sexual cycles during senescence involve modifications in the regulatory action of excitatory amino acid neurotransmission on GnRH neurons, we measured the in vitro effects of NMDA on GnRH release by the anterior preoptic and medial basal hypothalamic areas (APOA-MBH) of castrated aging (18 months old) and young (90 days of age) rats. Excitatory Amino Acids 220-241 gonadotropin releasing hormone 1 Rattus norvegicus 263-267 9247881-0 1996 Neuromodulation by Mg2+ and polyamines of excitatory amino acid currents in rodent neurones in culture. Excitatory Amino Acids 42-63 mucin 7, secreted Homo sapiens 19-22 8973819-1 1996 In order to evaluate if the changes of the hypothalamic-pituitary-ovary axis that induce a decrease in fertility and modifications in the sexual cycles during senescence involve modifications in the regulatory action of excitatory amino acid neurotransmission on GnRH neurons, we measured the in vitro effects of NMDA on GnRH release by the anterior preoptic and medial basal hypothalamic areas (APOA-MBH) of castrated aging (18 months old) and young (90 days of age) rats. Excitatory Amino Acids 220-241 gonadotropin releasing hormone 1 Rattus norvegicus 321-325 8981455-4 1996 These results provide evidence of abnormal susceptibility to seizures induced by anti-GABAergic agents and agonists for central excitatory amino acids in Fyn-deficient mice. Excitatory Amino Acids 128-150 Fyn proto-oncogene Mus musculus 154-157 8930296-0 1996 Nociceptin (orphanin FQ), an endogenous ligand for the QRL1 (opioid-receptor-like1) receptor; modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli. Excitatory Amino Acids 146-168 prepronociceptin Rattus norvegicus 0-10 8930296-0 1996 Nociceptin (orphanin FQ), an endogenous ligand for the QRL1 (opioid-receptor-like1) receptor; modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli. Excitatory Amino Acids 146-168 prepronociceptin Rattus norvegicus 12-23 9086492-2 1996 The ability of the oxidants FeCl2 and H2O2 and the excitatory amino acid, N-methyl-D-aspartate (NMDA) to induce changes in astrocytic GS and glial fibrillary acidic protein (GFAP), were assessed in whole rat brain reaggregate cultures. Excitatory Amino Acids 51-72 glial fibrillary acidic protein Rattus norvegicus 141-172 9414455-0 1996 Mechanisms mediating the response of GnRH neurones to excitatory amino acids. Excitatory Amino Acids 54-76 gonadotropin releasing hormone 1 Homo sapiens 37-41 8906578-0 1996 Platelet-activating factor in the modulation of excitatory amino acid neurotransmitter release and of gene expression. Excitatory Amino Acids 48-69 PCNA clamp associated factor Homo sapiens 0-26 8906578-5 1996 PAF enhances excitatory amino acid release in synaptic pairs from primary hippocampal cultures by a presynaptic mechanism. Excitatory Amino Acids 13-34 PCNA clamp associated factor Homo sapiens 0-3 8883899-8 1996 The protein kinase C (PKC) inhibitor, chelerythrine chloride, also reduced excitatory amino acid efflux, wheres the PKC activator phorbol 12-myristate 13-acetate (PMA) enhanced their release. Excitatory Amino Acids 75-96 protein kinase C, gamma Rattus norvegicus 4-20 8883899-8 1996 The protein kinase C (PKC) inhibitor, chelerythrine chloride, also reduced excitatory amino acid efflux, wheres the PKC activator phorbol 12-myristate 13-acetate (PMA) enhanced their release. Excitatory Amino Acids 75-96 protein kinase C, gamma Rattus norvegicus 22-25 8883899-8 1996 The protein kinase C (PKC) inhibitor, chelerythrine chloride, also reduced excitatory amino acid efflux, wheres the PKC activator phorbol 12-myristate 13-acetate (PMA) enhanced their release. Excitatory Amino Acids 75-96 protein kinase C, gamma Rattus norvegicus 116-119 8643086-9 1996 Although EAAC1-mediated transport and cortical synaptosomal transport have similar pharmacological profiles, five excitatory amino acid analogues were > or= 3-fold more potent as inhibitors of transport into cortical synaptosomes than of transport into EAAC1-injected oocytes. Excitatory Amino Acids 114-135 solute carrier family 1 member 1 Rattus norvegicus 256-261 8667006-6 1996 We conclude that the evoked release of excitatory amino acids and purines is under an inhibitory control by A1 receptors and class II mGluRs, i.e., mGluR2 or 3, which appear to operate through a common transduction pathway. Excitatory Amino Acids 39-61 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 148-154 8649576-1 1996 Researchers have proposed that increased release of excitatory amino acids (EAAs) is involved in the pathogenesis of dementia of the Alzheimer type (DAT), and CSF EAA concentrations have been measured to obtain evidence in support of this hypothesis. Excitatory Amino Acids 52-74 solute carrier family 6 member 3 Homo sapiens 149-152 8649576-1 1996 Researchers have proposed that increased release of excitatory amino acids (EAAs) is involved in the pathogenesis of dementia of the Alzheimer type (DAT), and CSF EAA concentrations have been measured to obtain evidence in support of this hypothesis. Excitatory Amino Acids 76-80 solute carrier family 6 member 3 Homo sapiens 149-152 8649576-1 1996 Researchers have proposed that increased release of excitatory amino acids (EAAs) is involved in the pathogenesis of dementia of the Alzheimer type (DAT), and CSF EAA concentrations have been measured to obtain evidence in support of this hypothesis. Excitatory Amino Acids 76-79 solute carrier family 6 member 3 Homo sapiens 149-152 8649576-2 1996 However, previous comparisons of CSF EAA concentrations in patients with DAT and in controls have yielded inconsistent results, perhaps because patient samples have been heterogeneous as to dementia severity. Excitatory Amino Acids 37-40 solute carrier family 6 member 3 Homo sapiens 73-76 8684625-12 1996 Thus, mGluR2 and mGluR3 are found in various combinations of presynaptic, postsynaptic and glial localizations that may reflect differential modulation of excitatory amino acid transmission. Excitatory Amino Acids 155-176 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 6-12 8684625-12 1996 Thus, mGluR2 and mGluR3 are found in various combinations of presynaptic, postsynaptic and glial localizations that may reflect differential modulation of excitatory amino acid transmission. Excitatory Amino Acids 155-176 glutamate receptor, ionotropic, AMPA3 (alpha 3) Mus musculus 17-23 8884386-0 1996 Stimulation of glutamine synthetase activity by excitatory amino acids in astrocyte cultures derived from aged mouse cerebral hemispheres may be associated with non-N-methyl-D-aspartate receptor activation. Excitatory Amino Acids 48-70 glutamate-ammonia ligase (glutamine synthetase) Mus musculus 15-35 8884386-2 1996 In the present study, we examined the effects of excitatory amino acids on the activity of glutamine synthetase, a marker for astrocytes. Excitatory Amino Acids 49-71 glutamate-ammonia ligase (glutamine synthetase) Mus musculus 91-111 8627386-8 1996 The stress-induced CA3 apical dendritic atrophy in subordinates was prevented by administering daily oral doses of the antiepileptic drug phenytoin (Dilantin, Sigma, St. Louis, MO) (200 mg/kg), which interferes with excitatory amino acid (EAA) action. Excitatory Amino Acids 216-237 carbonic anhydrase 3 Rattus norvegicus 19-22 8627386-8 1996 The stress-induced CA3 apical dendritic atrophy in subordinates was prevented by administering daily oral doses of the antiepileptic drug phenytoin (Dilantin, Sigma, St. Louis, MO) (200 mg/kg), which interferes with excitatory amino acid (EAA) action. Excitatory Amino Acids 239-242 carbonic anhydrase 3 Rattus norvegicus 19-22 8887960-8 1996 Activation of the human mGluR3, permanently expressed in Baby Hamster Kidney (BHK) cells, by excitatory amino acid inhibits the forskolin-stimulated accumulation of intracellular cAMP. Excitatory Amino Acids 93-114 glutamate receptor, ionotropic, AMPA3 (alpha 3) Mus musculus 24-30 8643086-0 1996 Comparison of Na+-dependent glutamate transport activity in synaptosomes, C6 glioma, and Xenopus oocytes expressing excitatory amino acid carrier 1 (EAAC1). Excitatory Amino Acids 116-137 solute carrier family 1 member 1 Rattus norvegicus 149-154 8848266-5 1996 PLA2, which is activated by cerebral ischemia, could thus contribute to the extracellular accumulation of neurotoxic excitatory amino acids. Excitatory Amino Acids 117-139 phospholipase A2 group IB Homo sapiens 0-4 8929974-0 1996 Corticotropin-releasing factor modulates basal and stress-induced excitatory amino acid release in the locus coeruleus of conscious rats. Excitatory Amino Acids 66-87 corticotropin releasing hormone Rattus norvegicus 0-30 8789384-5 1996 We have investigated in vivo a possible role of excitatory amino acids (EAAs) in the neural control of release of vasopressin (AVP) and oxytocin from the neurohypophysis. Excitatory Amino Acids 48-70 arginine vasopressin Rattus norvegicus 114-125 8845955-0 1995 The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid. Excitatory Amino Acids 61-83 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 17-22 8821751-1 1995 Stimulation of ascending catecholaminergic neurones of the A1 region in ventrolateral medulla by excitatory amino acids mediate neurohypophysial vasopressin secretion triggered by hypovolemic hypotension. Excitatory Amino Acids 97-119 arginine vasopressin Homo sapiens 145-156 8845955-3 1995 We have previously shown that the stimulation of N-methyl-D-aspartate receptors by excitatory amino acids is essential for the neuronal injury observed with gp120. Excitatory Amino Acids 83-105 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 157-162 8845955-4 1995 Here we show that gp120 impairs astrocyte uptake of excitatory amino acids and the excess glutamate thus engendered may contribute to the increased neuronal damage. Excitatory Amino Acids 52-74 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 18-23 8845955-5 1995 We also studied the mechanism whereby gp120 inhibits the uptake of excitatory amino acids by astrocytes. Excitatory Amino Acids 67-89 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 38-43 8845955-6 1995 We present data suggesting that at least one pathway involves a direct effect of gp120 on macrophages, which in turn release arachidonic acid, a known inhibitor of excitatory amino acid uptake by astrocytes. Excitatory Amino Acids 164-185 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 81-86 7601649-0 1995 Influence of excitatory amino acids and ischemia on rat retinal choline acetyltransferase-containing cells. Excitatory Amino Acids 13-35 choline O-acetyltransferase Rattus norvegicus 64-89 8561307-2 1995 The excitatory amino acids, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and kainic acid, were applied to area CA1, and the resulting depolarizations were measured using the grease-gap electrophysiological technique. Excitatory Amino Acids 4-26 carbonic anhydrase 1 Rattus norvegicus 127-130 8561307-6 1995 These results indicate that ethanol has potent antagonist actions against non-N-methyl-D-aspartate (NMDA) excitatory amino acid-induced neuronal depolarizations in hippocampal area CA1. Excitatory Amino Acids 106-127 carbonic anhydrase 1 Rattus norvegicus 181-184 7566744-6 1995 Endogenous excitatory amino acid is one of the possible neurotransmitters that regulate LHRH release at the nerve terminal in ME. Excitatory Amino Acids 11-32 gonadotropin releasing hormone 1 Homo sapiens 88-92 7478217-0 1995 Elevated striatal Fos immunoreactivity following 6-hydroxydopamine lesioning of the rat is mediated by excitatory amino acid transmission. Excitatory Amino Acids 103-124 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 18-21 7589325-15 1995 To study whether NGF is able to regulate EAA excitotoxicity on striatal cholinergic neurons, we studied ChAT activity 7 days after simultaneous injection of NGF plus QUIN, KA, or QUIS. Excitatory Amino Acids 41-44 nerve growth factor Rattus norvegicus 17-20 7589325-16 1995 Intrastriatal injection of exogenous NGF was able to block the decrease in ChAT activity observed following EAA injection alone. Excitatory Amino Acids 108-111 nerve growth factor Rattus norvegicus 37-40 8830285-1 1995 Alterations of excitatory amino acid neurotransmitters have previously been described in brain in congenital ornithine transcarbamylase (OTC) deficiency. Excitatory Amino Acids 15-36 ornithine transcarbamylase Mus musculus 109-135 8830285-1 1995 Alterations of excitatory amino acid neurotransmitters have previously been described in brain in congenital ornithine transcarbamylase (OTC) deficiency. Excitatory Amino Acids 15-36 ornithine transcarbamylase Mus musculus 137-140 7597071-8 1995 Sequence analysis of Pxa1p, ALDp, and related ABC transporters reveals a possible fatty acid binding domain and a 14-amino acid EAA-like motif, previously described only in prokaryotes. Excitatory Amino Acids 128-131 ATP-binding cassette long-chain fatty acid transporter PXA1 Saccharomyces cerevisiae S288C 21-26 7597071-8 1995 Sequence analysis of Pxa1p, ALDp, and related ABC transporters reveals a possible fatty acid binding domain and a 14-amino acid EAA-like motif, previously described only in prokaryotes. Excitatory Amino Acids 128-131 ATP binding cassette subfamily D member 1 Homo sapiens 28-32 7478684-0 1995 Infusion of substance P or neurokinin A by microdialysis alters responses of primate spinothalamic tract neurons to cutaneous stimuli and to iontophoretically released excitatory amino acids. Excitatory Amino Acids 168-190 tachykinin precursor 1 Homo sapiens 12-23 7478684-0 1995 Infusion of substance P or neurokinin A by microdialysis alters responses of primate spinothalamic tract neurons to cutaneous stimuli and to iontophoretically released excitatory amino acids. Excitatory Amino Acids 168-190 tachykinin precursor 1 Homo sapiens 27-39 7659296-5 1995 These data suggest that 5-HT3 receptor activation in the rat nucleus tractus solitarius can affect excitatory amino acid neurotransmission in this region of the medulla oblongata. Excitatory Amino Acids 99-120 5-hydroxytryptamine receptor 3A Rattus norvegicus 24-38 7659277-0 1995 Excitatory amino acid-induced cytotoxicity in primary cultures of mouse cerebellar granule cells correlates with elevated, sustained c-fos proto-oncogene expression. Excitatory Amino Acids 0-21 FBJ osteosarcoma oncogene Mus musculus 133-138 7544224-0 1995 Effects of excitatory amino acid lesions upon neurokinin B and acetylcholine neurons in the nucleus basalis of the rat. Excitatory Amino Acids 11-32 tachykinin precursor 3 Rattus norvegicus 46-58 7659277-1 1995 An elevated, sustained expression of c-fos mRNA was found in primary cultures of mouse cerebellar granule cells following exposure to toxic concentrations of the excitatory amino acids, L-glutamate, L-homocysteate, S-sulpho-L-cysteine and N-methyl-D-aspartate (NMDA), using leakage of lactate dehydrogenase (LDH) as an indicator of cytotoxicity. Excitatory Amino Acids 162-184 FBJ osteosarcoma oncogene Mus musculus 37-42 7608334-9 1995 The excitatory amino acids increased both Fos- and Jun-like immunoreactivity, while GABA generally showed no such stimulatory effect. Excitatory Amino Acids 4-26 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 42-45 7538561-0 1995 Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor. Excitatory Amino Acids 30-51 interleukin 1 beta Homo sapiens 0-18 7538561-2 1995 In the present study, we investigated the possible neuroprotective actions of the cytokine human recombinant interleukin-1 beta (hrIL-1 beta) against excitatory amino acid (EAA)-induced neurodegeneration in cultured primary cortical neurons. Excitatory Amino Acids 150-171 interleukin 1 beta Homo sapiens 109-127 7538561-2 1995 In the present study, we investigated the possible neuroprotective actions of the cytokine human recombinant interleukin-1 beta (hrIL-1 beta) against excitatory amino acid (EAA)-induced neurodegeneration in cultured primary cortical neurons. Excitatory Amino Acids 173-176 interleukin 1 beta Homo sapiens 109-127 7620884-0 1995 Temporal response and effects of excitatory amino acid antagonism on microtubule-associated protein 2 immunoreactivity following experimental brain injury in rats. Excitatory Amino Acids 33-54 microtubule-associated protein 2 Rattus norvegicus 69-101 7624047-2 1995 In the cerebellar cortex AChE has been shown to potentiate synaptic responses evoked by excitatory amino acids. Excitatory Amino Acids 88-110 acetylcholinesterase Cavia porcellus 25-29 7608334-11 1995 In cobalt-treated dark-adapted retinas, some excitatory amino acids increased cytoplasmic Fos-like immunoreactivity in the somata and processes of large cells in the ganglion cell layer. Excitatory Amino Acids 45-67 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 90-93 7720821-11 1995 These results provide support for the hypothesis that locally secreted HIV peptides, such as gp120, may potentiate the neurotoxicity of endogenous excitatory amino acid neurotransmitters in HIV-infected brain. Excitatory Amino Acids 147-168 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 93-98 7695237-5 1995 Tat-induced depolarizations and cytotoxicity were blocked by the excitatory amino acid antagonist kynurenate. Excitatory Amino Acids 65-86 tyrosine aminotransferase Homo sapiens 0-3 8808177-1 1995 Stimulation of the 5-HT2A receptors by serotonin has been reported to exert an excitatory effect on neocortical neurons in rats and mice, to facilitate ischaemia-induced release of excitatory amino acids and to mediate the vasomotor constrictor component of the response of blood vessels to 5-HT. Excitatory Amino Acids 181-203 5-hydroxytryptamine receptor 2A Rattus norvegicus 19-25 7648607-8 1995 There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator. Excitatory Amino Acids 76-98 gonadotropin releasing hormone 1 Rattus norvegicus 153-157 7648607-8 1995 There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator. Excitatory Amino Acids 76-98 gonadotropin releasing hormone 1 Rattus norvegicus 233-237 7746359-5 1995 The findings of this study reveal that the primary effect of CGRP is to suppress spontaneous and excitatory amino acid-induced activity. Excitatory Amino Acids 97-118 calcitonin related polypeptide alpha Homo sapiens 61-65 7746359-10 1995 In summary, the presence of CGRP in selected populations of mossy fibers, together with serotoninergic afferents, decreases the responsiveness of Purkinje cells to excitatory amino acids as well as synaptically-driven activity. Excitatory Amino Acids 164-186 calcitonin related polypeptide alpha Homo sapiens 28-32 8665266-2 1995 In an attempt to gain further insight into the role of this peptide in brain functioning we investigated the effects of GLP-1 (7-36)amide on the release of excitatory amino acid neurotransmitters by the ventromedial hypothalamus using an experimental microdialysis approach. Excitatory Amino Acids 156-177 glucagon Rattus norvegicus 120-125 7589290-4 1995 However, when the excitatory amino acid NMDA was injected into Ipc it produced a significant reduction in the visually driven firing of 75% of tectal neurons when their ERFs were within the isthmic ERF, while similar application of NMDA into Imc had no effect on the visually driven response of 94% of tectal neurons. Excitatory Amino Acids 18-39 ETS2 repressor factor Homo sapiens 169-172 7898610-6 1994 These observations establish that ODC/PA cascade play an important role in transduction of excitatory amino acid mediated signals at NMDA receptors. Excitatory Amino Acids 91-112 ornithine decarboxylase 1 Rattus norvegicus 34-37 7853017-5 1994 We have analysed the effects of riluzole, a compound reducing the excitatory amino acid release on gp120-induced neurotoxicity in primary neuronal cultures. Excitatory Amino Acids 66-87 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 99-104 7999115-5 1994 Since these antagonists do not interact with endothelin receptors, we conclude that release of an endogenous EAA may contribute to the hypotensive action of central ET-1. Excitatory Amino Acids 109-112 endothelin 1 Rattus norvegicus 165-169 7968367-2 1994 Treatment with the selective excitatory amino acid agonist kainate was used to activate AP-1 formation. Excitatory Amino Acids 29-50 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 88-92 7827626-0 1994 The hypothalamic peptides, beta-endorphin, neuropeptide K and interleukin-1 beta, and the opiate morphine, enhance the excitatory amino acid-induced LH release under the influence of gonadal steroids. Excitatory Amino Acids 119-140 interleukin 1 beta Rattus norvegicus 62-80 7854614-0 1994 Altered modulation by excitatory amino acids of cortical phosphatidylinositol system stimulated by carbachol in rats poisoned by an anti-cholinesterase compound, diisopropyl fluorophosphate. Excitatory Amino Acids 22-44 butyrylcholinesterase Rattus norvegicus 137-151 7816198-4 1994 Excitatory postsynaptic potentials mediated primarily by excitatory amino acids were also depressed by angiotensin II. Excitatory Amino Acids 57-79 angiotensinogen Homo sapiens 103-117 7969775-1 1994 Recent findings indicate that excitatory amino acids (EAAs) can modulate growth hormone (GH) secretion in several mammalian species in vivo and in vitro. Excitatory Amino Acids 30-52 growth hormone 1 Homo sapiens 73-87 7969775-1 1994 Recent findings indicate that excitatory amino acids (EAAs) can modulate growth hormone (GH) secretion in several mammalian species in vivo and in vitro. Excitatory Amino Acids 30-52 growth hormone 1 Homo sapiens 89-91 7953701-0 1994 Neurotrophin-4/5 protects hippocampal and cortical neurons against energy deprivation- and excitatory amino acid-induced injury. Excitatory Amino Acids 91-112 neurotrophin 4 Rattus norvegicus 0-16 7969911-4 1994 We investigated if calretinin-containing neurons have a survival advantage in rat neocortical cultures treated with a calcium ionophore or excitatory amino acids. Excitatory Amino Acids 139-161 calbindin 2 Rattus norvegicus 19-29 7969911-11 1994 We found again that calretinin-containing neurons were relatively spared after exposure to the excitatory amino acids; at doses of N-methyl-D-aspartate and kainate that produced a 32-40% loss of calretinin immunonegative neurons, only 2-10% of calretinin immunopositive neurons died. Excitatory Amino Acids 95-117 calbindin 2 Rattus norvegicus 20-30 7515817-6 1994 Taken together, the results demonstrate that endogenous excitatory amino acid neurotransmitters, acting at AMPA receptors, tonically inhibit both TIDA and PHDA neurons, and thereby increase the secretion of prolactin and alpha-MSH in male and female rats. Excitatory Amino Acids 56-77 proopiomelanocortin Rattus norvegicus 221-230 8156903-11 1994 As nuclear primary transcript levels presumably reflect GnRH gene transcription, and these levels are unaltered, the present study indicates that the regulation of GnRH gene expression by excitatory amino acids occurs at a posttranscriptional level. Excitatory Amino Acids 188-210 gonadotropin releasing hormone 1 Rattus norvegicus 164-168 8154872-3 1994 Since lack of substrate delivery, excitatory amino acid toxicity, and calcium entry into cells appear to be important processes in neuronal death after ischemia, we tested the hypothesis that pretreatment with basic fibroblast growth factor limits infarct size in a model of focal cerebral ischemia in vivo. Excitatory Amino Acids 34-55 myotrophin Rattus norvegicus 227-240 7953634-1 1994 Brief exposure of rat hippocampal slices to quisqualic acid (QUIS) sensitizes neurons to depolarization by the alpha-amino-omega-phosphonate excitatory amino acid (EAA) analogues AP4, AP5 and AP6. Excitatory Amino Acids 164-167 replication initiator 1 Rattus norvegicus 179-182 7969503-11 1994 It appears that the chemoreceptor stimulation produces an increase in vasopressin release and the enhancement of vasopressin release is also mediated by an increase in excitatory amino acid inputs in the RVLM. Excitatory Amino Acids 168-189 arginine vasopressin Rattus norvegicus 113-124 8119138-1 1994 Previous studies demonstrated that an excitatory amino acid analog, N-methyl-D-aspartate (NMDA), stimulates GnRH secretion in the rat, prepubertal primate, and ovine fetus at the hypothalamic level. Excitatory Amino Acids 38-59 gonadotropin releasing hormone 1 Rattus norvegicus 108-112 7909924-1 1994 Intracellular recording from CA1 neurones of the rat hippocampal slice preparation was carried out to assess the ability of the endogenously-occurring neuropeptide thyrotropin-releasing hormone (TRH) to modulate responses elicited by the excitatory amino acid agonist N-methyl-D-aspartate (NMDA). Excitatory Amino Acids 238-259 thyrotropin releasing hormone Rattus norvegicus 195-198 7902625-0 1993 Basic fibroblast growth factor protects cerebrocortical neurons against excitatory amino acid toxicity in vitro. Excitatory Amino Acids 72-93 fibroblast growth factor 2 Rattus norvegicus 0-30 7903356-1 1994 In the present study, extracellular levels of the neuropeptide cholecystokinin (CCK), of the monoamine dopamine and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), and of the excitatory amino acids glutamate and aspartate were simultaneously monitored by microdialysis in the neostriatum of halothane-anesthetized rats under basal and K(+)-depolarizing conditions. Excitatory Amino Acids 211-233 cholecystokinin Rattus norvegicus 80-83 7507336-3 1994 We now report that TNF beta and TNF alpha (1-100 ng/ml) can protect cultured embryonic rat hippocampal, septal, and cortical neurons against glucose deprivation-induced injury and excitatory amino acid toxicity. Excitatory Amino Acids 180-201 lymphotoxin alpha Rattus norvegicus 19-27 7507336-3 1994 We now report that TNF beta and TNF alpha (1-100 ng/ml) can protect cultured embryonic rat hippocampal, septal, and cortical neurons against glucose deprivation-induced injury and excitatory amino acid toxicity. Excitatory Amino Acids 180-201 tumor necrosis factor Rattus norvegicus 32-41 7907936-0 1994 Effects of excitatory amino acid transmitters on hypothalamic corticotropin-releasing hormone (CRH) and arginine-vasopressin (AVP) release in vitro: implications in pituitary-adrenal regulation. Excitatory Amino Acids 11-32 corticotropin releasing hormone Homo sapiens 95-98 7907936-1 1994 The effect of excitatory amino acid (EAA) on the release of CRH and AVP--two major neurohumoral activators of the hypothalamic-pituitary-adrenal axis--was studied by in vitro perifusion of hypothalamic organ explants with various concentrations of EAA receptor agonists and antagonists. Excitatory Amino Acids 14-35 corticotropin releasing hormone Homo sapiens 60-63 7907936-1 1994 The effect of excitatory amino acid (EAA) on the release of CRH and AVP--two major neurohumoral activators of the hypothalamic-pituitary-adrenal axis--was studied by in vitro perifusion of hypothalamic organ explants with various concentrations of EAA receptor agonists and antagonists. Excitatory Amino Acids 37-40 corticotropin releasing hormone Homo sapiens 60-63 7509434-1 1994 Recent immunocytochemical studies of cerebellar nitric oxide synthase (NOS) and cGMP have aided dramatically in defining possible cellular sources of cGMP generation in the signal transduction cascade evoked by excitatory amino acids in the cerebellum. Excitatory Amino Acids 211-233 nitric oxide synthase 1, neuronal Mus musculus 48-69 8202441-8 1994 Moreover, the involvement of the arginine vasopressin neuropeptide in the hypertension induced by administration of excitatory amino acids into the PAG area has been demonstrated. Excitatory Amino Acids 116-138 arginine vasopressin Homo sapiens 42-53 7902298-1 1993 We have investigated the ability of bFGF to protect cerebellar neurons from neurotoxicity by excitatory amino acids. Excitatory Amino Acids 93-115 fibroblast growth factor 2 Homo sapiens 36-40 7902625-1 1993 BACKGROUND AND PURPOSE: Previous studies have shown that basic fibroblast growth factor protects against excitatory amino acid toxicity in cultured hippocampal, striatal, and cerebellar neurons. Excitatory Amino Acids 105-126 myotrophin Rattus norvegicus 74-87 8376986-2 1993 At low concentrations (10(-13)-10(-12) M), IL-2 potentiated [3H]DA release evoked by the excitatory amino acids N-methyl-D-aspartate (NMDA) and kainate, whereas higher IL-2 concentrations (10(-9)-10(-8) M) had no effect. Excitatory Amino Acids 89-111 interleukin 2 Rattus norvegicus 43-47 8271308-0 1993 Induction of c-fos by excitatory amino acids in developing chick retina is affected by changes in cellular interactions. Excitatory Amino Acids 22-44 Fos proto-oncogene, AP-1 transcription factor subunit Gallus gallus 15-18 7507397-3 1993 Cellular damage induced by the excitatory amino acids in the pyramidal (CA1-CA4) and dentate granule neurones (DG) was assessed histologically 24 h after the injection. Excitatory Amino Acids 31-53 carbonic anhydrase 1 Rattus norvegicus 72-79 8284030-0 1993 Altered luteinizing hormone and prolactin responses to excitatory amino acids during lactation. Excitatory Amino Acids 55-77 prolactin Rattus norvegicus 32-41 8392536-11 1993 These data indicate a high degree of selectivity in the distribution of kainate receptors composed of GluR5/6/7 subunits, and suggest that functional specificity and diversity in the ubiquitous excitatory amino acid-utilizing axonal systems in neocortex are achieved in part by the differential association of particular glutamate receptor subunits with specific cortical circuits. Excitatory Amino Acids 194-215 glutamate ionotropic receptor kainate type subunit 1 Homo sapiens 102-107 8284035-10 1993 Administration of an excitatory amino acid antagonist (MK-801) blocked the increase of neuropeptide Y by light, while an agonist (N-methyl-D-aspartate) induced similar facilitatory effects to that of light on the neuropeptide Y level in the rat suprachiasmatic nucleus. Excitatory Amino Acids 21-42 pyroglutamylated RFamide peptide Rattus norvegicus 87-99 8104340-6 1993 We postulate that the constitutive phenotype of cerebellar granule cells is glutamate-resistant and becomes responsive to excitatory amino acids under the action of epigenetic cues among which IGF-I may be one of those operative in vivo. Excitatory Amino Acids 122-144 insulin like growth factor 1 Homo sapiens 193-198 8221072-5 1993 Exposure of neurons to beta AP resulted in increased sensitivity to the [Ca2+]i-elevating and neurodegenerative effects of excitatory amino acids. Excitatory Amino Acids 123-145 amyloid beta precursor protein Homo sapiens 23-30 7903433-2 1993 Recent studies indicate that excitatory amino acids may play an important role in the regulation of GnRH secretion and gene expression by steroids. Excitatory Amino Acids 29-51 gonadotropin releasing hormone 1 Rattus norvegicus 100-104 7903433-3 1993 Therefore the present study attempts to examine whether excitatory amino acids are involved in the P-induced GnRH gene expression and release in vitro. Excitatory Amino Acids 56-78 gonadotropin releasing hormone 1 Rattus norvegicus 109-113 7903433-7 1993 These results clearly indicate that excitatory amino acids by way of NMDA receptor are involved in the transsynaptic regulation of GnRH gene expression. Excitatory Amino Acids 36-58 gonadotropin releasing hormone 1 Rattus norvegicus 131-135 8319564-0 1993 Evidence that luteinizing hormone suppression in response to inhibitory neuropeptides, beta-endorphin, interleukin-1 beta, and neuropeptide-K, may involve excitatory amino acids. Excitatory Amino Acids 155-177 interleukin 1 beta Rattus norvegicus 103-121 8390443-3 1993 This study tested the hypothesis that SLN-evoked inspiratory termination requires excitatory amino acid (EAA) neurotransmission in medial aspects of the NTS. Excitatory Amino Acids 82-103 neurotensin Felis catus 153-156 8103684-0 1993 Cytoplasmic calcium buffer, calbindin-D28k, is regulated by excitatory amino acids. Excitatory Amino Acids 60-82 calbindin 1 Rattus norvegicus 28-37 8390443-3 1993 This study tested the hypothesis that SLN-evoked inspiratory termination requires excitatory amino acid (EAA) neurotransmission in medial aspects of the NTS. Excitatory Amino Acids 105-108 neurotensin Felis catus 153-156 8436614-1 1993 Basic fibroblast growth factor (bFGF) is a polypeptide that promotes neuronal survival and blocks excitatory amino acid (EAA) neurotoxicity in vitro at very low concentrations. Excitatory Amino Acids 98-119 fibroblast growth factor 2 Rattus norvegicus 0-30 8436614-1 1993 Basic fibroblast growth factor (bFGF) is a polypeptide that promotes neuronal survival and blocks excitatory amino acid (EAA) neurotoxicity in vitro at very low concentrations. Excitatory Amino Acids 98-119 fibroblast growth factor 2 Rattus norvegicus 32-36 8436614-1 1993 Basic fibroblast growth factor (bFGF) is a polypeptide that promotes neuronal survival and blocks excitatory amino acid (EAA) neurotoxicity in vitro at very low concentrations. Excitatory Amino Acids 121-124 fibroblast growth factor 2 Rattus norvegicus 0-30 8436614-1 1993 Basic fibroblast growth factor (bFGF) is a polypeptide that promotes neuronal survival and blocks excitatory amino acid (EAA) neurotoxicity in vitro at very low concentrations. Excitatory Amino Acids 121-124 fibroblast growth factor 2 Rattus norvegicus 32-36 8274762-2 1993 The results from studies of extracellular single-unit recordings and of photic induction of Fos-like immunoreactivity (Fos-lir) indicate that excitatory amino acid (EAA) transmission, and particularly activation of the N-methyl-D-aspartate (NMDA) receptor subtype, is important for conveying photic information to suprachiasmatic nucleus (SCN) cells. Excitatory Amino Acids 142-163 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 92-95 8097287-0 1993 Differential involvement of protein kinase C in transmitter release and response to excitatory amino acids in cultured cerebellar neurons. Excitatory Amino Acids 84-106 proline rich transmembrane protein 2 Homo sapiens 28-44 7686108-0 1993 Differential activation and survival of basal forebrain neurons following infusions of excitatory amino acids: studies with the immediate early gene c-fos. Excitatory Amino Acids 87-109 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 149-154 8458712-2 1993 In bacterial meningitis, intrathecal synthesis of TNF-alpha and IL-1 is likely to contribute to CNS injury by recruitment and activation of inflammatory cells with subsequent release of toxic factors, such as reactive oxygen intermediates and excitatory amino acids (glutamate), leading to neuronal cell death with neurologic sequelae. Excitatory Amino Acids 243-265 tumor necrosis factor Rattus norvegicus 50-59 8274762-2 1993 The results from studies of extracellular single-unit recordings and of photic induction of Fos-like immunoreactivity (Fos-lir) indicate that excitatory amino acid (EAA) transmission, and particularly activation of the N-methyl-D-aspartate (NMDA) receptor subtype, is important for conveying photic information to suprachiasmatic nucleus (SCN) cells. Excitatory Amino Acids 142-163 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 119-122 8274762-2 1993 The results from studies of extracellular single-unit recordings and of photic induction of Fos-like immunoreactivity (Fos-lir) indicate that excitatory amino acid (EAA) transmission, and particularly activation of the N-methyl-D-aspartate (NMDA) receptor subtype, is important for conveying photic information to suprachiasmatic nucleus (SCN) cells. Excitatory Amino Acids 165-168 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 92-95 8274762-2 1993 The results from studies of extracellular single-unit recordings and of photic induction of Fos-like immunoreactivity (Fos-lir) indicate that excitatory amino acid (EAA) transmission, and particularly activation of the N-methyl-D-aspartate (NMDA) receptor subtype, is important for conveying photic information to suprachiasmatic nucleus (SCN) cells. Excitatory Amino Acids 165-168 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 119-122 8274763-4 1993 Microinjection of excitatory amino acid (EAA) antagonists into the region of the SCN attenuates light-induced phase advances of the free-running activity rhythm and light-induced Fos expression in the hamster SCN. Excitatory Amino Acids 18-39 proto-oncogene c-Fos Mesocricetus auratus 179-182 8274763-4 1993 Microinjection of excitatory amino acid (EAA) antagonists into the region of the SCN attenuates light-induced phase advances of the free-running activity rhythm and light-induced Fos expression in the hamster SCN. Excitatory Amino Acids 41-44 proto-oncogene c-Fos Mesocricetus auratus 179-182 1281498-7 1992 The present study suggests that SP has an important modulatory role on excitatory amino acid activity in the spinal cord that is mediated by an action of the NH2 terminal of SP at a non-neurokinin receptor. Excitatory Amino Acids 71-92 tachykinin 1 Mus musculus 32-34 1337935-1 1992 We have studied the effect of excitatory amino acids on the expression of mRNA for the immediate early genes c-fos, c-jun, jun-B, and NGF-1A in isolated cortical astrocytes. Excitatory Amino Acids 30-52 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 109-114 1337935-1 1992 We have studied the effect of excitatory amino acids on the expression of mRNA for the immediate early genes c-fos, c-jun, jun-B, and NGF-1A in isolated cortical astrocytes. Excitatory Amino Acids 30-52 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 116-121 1359961-1 1992 We have investigated the direct effects of different neuroexcitatory amino acids (EAA) on the secretion of CRH-41 and arginine vasopressin (AVP) from the rat hypothalamus maintained in vitro. Excitatory Amino Acids 82-85 corticotropin releasing hormone Rattus norvegicus 107-110 1359961-1 1992 We have investigated the direct effects of different neuroexcitatory amino acids (EAA) on the secretion of CRH-41 and arginine vasopressin (AVP) from the rat hypothalamus maintained in vitro. Excitatory Amino Acids 82-85 arginine vasopressin Rattus norvegicus 127-138 1281498-7 1992 The present study suggests that SP has an important modulatory role on excitatory amino acid activity in the spinal cord that is mediated by an action of the NH2 terminal of SP at a non-neurokinin receptor. Excitatory Amino Acids 71-92 tachykinin 1 Mus musculus 174-176 1480552-10 1992 However, hepatic GST activity toward EAA was significantly inhibited in mice whereas significantly increased in rats and guinea-pigs. Excitatory Amino Acids 37-40 hematopoietic prostaglandin D synthase Mus musculus 17-20 1337286-2 1992 NMDAR-1, GluR2 and GluR3 mRNAs were expressed in the large neurones (type I) of the ganglion which innervate inner hair cells (IHCs), a sensory cell type likely to use an excitatory amino acid as a neurotransmitter. Excitatory Amino Acids 171-192 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 0-7 1337286-2 1992 NMDAR-1, GluR2 and GluR3 mRNAs were expressed in the large neurones (type I) of the ganglion which innervate inner hair cells (IHCs), a sensory cell type likely to use an excitatory amino acid as a neurotransmitter. Excitatory Amino Acids 171-192 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 9-14 1337286-2 1992 NMDAR-1, GluR2 and GluR3 mRNAs were expressed in the large neurones (type I) of the ganglion which innervate inner hair cells (IHCs), a sensory cell type likely to use an excitatory amino acid as a neurotransmitter. Excitatory Amino Acids 171-192 glutamate ionotropic receptor AMPA type subunit 3 Rattus norvegicus 19-24 1282748-2 1992 Neuronal AChE can be secreted from several brain regions, while purified AChE possesses several properties (in addition to its cholinesterase activity) that can affect neuronal function, including the abilities to influence certain membrane conductances, enhance excitatory amino acid transmission and hydrolyse peptides. Excitatory Amino Acids 263-284 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 1430201-3 1992 In particular, the frequency of pulsatile GnRH secretion increases at the onset of puberty, as can be shown by using hypothalamic explants of male rats of 15 and 25 d. Previous observations from us and others suggested that the initiation of puberty could involve a facilitatory effect of excitatory amino acids mediated through N-methyl-D-aspartate (NMDA) receptors. Excitatory Amino Acids 289-311 gonadotropin releasing hormone 1 Rattus norvegicus 42-46 1360862-1 1992 N-Acetylated-alpha-linked acidic dipeptidase (NAALADase) is a membrane-bound peptidase which hydrolyzes the endogenous neuropeptide N-acetylaspartylglutamate (NAAG) to N-acetylaspartate (NAA) and the excitatory amino acid, glutamate (Glu). Excitatory Amino Acids 200-221 folate hydrolase 1 Rattus norvegicus 0-44 1279137-4 1992 In order to identify a candidate excitatory neurotransmitter, the actions of excitatory amino acids (EAAs) on the membrane properties of mPRF neurons recorded in rat brainstem slices in vitro were studied. Excitatory Amino Acids 77-99 Spi-C transcription factor (Spi-1/PU.1 related) Mus musculus 137-141 1279137-4 1992 In order to identify a candidate excitatory neurotransmitter, the actions of excitatory amino acids (EAAs) on the membrane properties of mPRF neurons recorded in rat brainstem slices in vitro were studied. Excitatory Amino Acids 101-105 Spi-C transcription factor (Spi-1/PU.1 related) Mus musculus 137-141 1467929-4 1992 Unilateral electrolytic or excitatory amino acid induced lesions of the basal forebrain, including the nucleus of the diagonal band, result in reductions of AChE staining throughout ipsilateral granular retrosplenial cortex; particularly noteworthy are the reductions in layer I and the deeper cortical layers. Excitatory Amino Acids 27-48 acetylcholinesterase Rattus norvegicus 157-161 1328537-7 1992 We propose that kainate receptor-mediated dephosphorylation in NF-H is involved in the signal transduction of excitatory amino acids with consequences for neuronal functions dependent on intermediary filament phosphorylation. Excitatory Amino Acids 110-132 neurofilament heavy chain Rattus norvegicus 63-67 1360862-1 1992 N-Acetylated-alpha-linked acidic dipeptidase (NAALADase) is a membrane-bound peptidase which hydrolyzes the endogenous neuropeptide N-acetylaspartylglutamate (NAAG) to N-acetylaspartate (NAA) and the excitatory amino acid, glutamate (Glu). Excitatory Amino Acids 200-221 folate hydrolase 1 Rattus norvegicus 46-55 1320445-0 1992 Activation of 5-HT1C/2 receptors depresses polysynaptic reflexes and excitatory amino acid-induced motoneuron responses in frog spinal cord. Excitatory Amino Acids 69-90 5-hydroxytryptamine receptor 2C Homo sapiens 14-20 1519065-3 1992 These results indicate that the timing of NO release relative to high-frequency activation of CA1 synapses may be an important determinant of LTP generation and suggest that NO may play a positive or negative modulatory role in LTP depending on prior events at the tetanized synapse and the ambient concentration of excitatory amino acids. Excitatory Amino Acids 316-338 carbonic anhydrase 1 Homo sapiens 94-97 1308199-5 1992 Because phenytoin is also known to prevent ischemic damage, these results are consistent with a model in which stress- and corticosterone-induced CA3 dendritic atrophy is produced by excitatory amino acids released from the mossy fibers. Excitatory Amino Acids 183-205 carbonic anhydrase 3 Rattus norvegicus 146-149 1358646-0 1992 Ethanol inhibits release of excitatory amino acids from slices of hippocampal area CA1. Excitatory Amino Acids 28-50 carbonic anhydrase 1 Homo sapiens 83-86 1347243-9 1992 The increased capacity for glutamine synthetase may be important in normalizing extracellular glutamate following ischemia and protecting brain from the neurotoxic effects of this excitatory amino acid. Excitatory Amino Acids 180-201 glutamate-ammonia ligase Rattus norvegicus 27-47 1354998-1 1992 The effect of thyrotropin-releasing hormone (TRH) on the responses to excitatory amino acids was investigated in hypoglossal motoneurones in an in vitro preparation of the brainstem from guinea pigs using current clamp and discontinuous single electrode voltage clamp (dSEVC). Excitatory Amino Acids 70-92 thyrotropin releasing hormone Cavia porcellus 14-43 1354998-1 1992 The effect of thyrotropin-releasing hormone (TRH) on the responses to excitatory amino acids was investigated in hypoglossal motoneurones in an in vitro preparation of the brainstem from guinea pigs using current clamp and discontinuous single electrode voltage clamp (dSEVC). Excitatory Amino Acids 70-92 thyrotropin releasing hormone Cavia porcellus 45-48 1348527-1 1992 In this study we have investigated the effect of excitatory amino acids on the activity of glutamine synthetase, a glial-specific enzyme that plays a key role in the regulation of glutamate concentration in the CNS. Excitatory Amino Acids 49-71 glutamate-ammonia ligase Rattus norvegicus 91-111 1543352-3 1992 Synchronous bursting of CA1 hippocampal neurons occurs via nonsynaptic mechanisms in solutions containing very low [Ca2+] and excitatory amino acid antagonists. Excitatory Amino Acids 126-147 carbonic anhydrase 1 Rattus norvegicus 24-27 1347633-0 1992 The effects of excitatory amino acids on proenkephalin and prodynorphin mRNA levels in the hippocampal dentate gyrus of the rat; an in situ hybridization study. Excitatory Amino Acids 15-37 proenkephalin Rattus norvegicus 41-54 1347633-0 1992 The effects of excitatory amino acids on proenkephalin and prodynorphin mRNA levels in the hippocampal dentate gyrus of the rat; an in situ hybridization study. Excitatory Amino Acids 15-37 prodynorphin Rattus norvegicus 59-71 1347633-2 1992 As shown by an in situ immunohistochemical analysis, 3 h after the excitatory amino acids injections the rats displayed a bilateral profound elevation of the proenkephalin and prodynorphin mRNA levels in dentate gyrus granule cells (2-3 or 1.5-2 fold higher than control levels, respectively). Excitatory Amino Acids 67-89 proenkephalin Rattus norvegicus 158-171 1347633-2 1992 As shown by an in situ immunohistochemical analysis, 3 h after the excitatory amino acids injections the rats displayed a bilateral profound elevation of the proenkephalin and prodynorphin mRNA levels in dentate gyrus granule cells (2-3 or 1.5-2 fold higher than control levels, respectively). Excitatory Amino Acids 67-89 prodynorphin Rattus norvegicus 176-188 12106335-13 1992 Our data are consistent with the hypothesis that the excitatory action of l-AP4 results from a Ca2+-independent release of endogenous excitatory amino acids from some presynaptic neuronal or glial site. Excitatory Amino Acids 134-156 replication initiator 1 Rattus norvegicus 76-79 1334665-1 1992 A brief application of high K+ or excitatory amino acids (i.e. kainic acid) generated repetitive synchronized burst that persisted for the duration of the application, in the CA3 field. Excitatory Amino Acids 34-56 carbonic anhydrase 3 Homo sapiens 175-178 1425026-2 1992 The interaction is amongst noradrenaline and other neurotransmitters such as GABA (gamma-aminobutyric acid), opiates, serotonin and excitatory amino acids (N-methyl-D-aspartate, NMDA) on LHRH neuronal activity are complex. Excitatory Amino Acids 132-154 gonadotropin releasing hormone 1 Rattus norvegicus 187-191 1351266-3 1992 Local stimulation with excitatory amino acids, applied from a microelectrode with 1-2-s iontophoretic pulses at the dendrite, induced a rapid increase in intracellular Ca2+ predominantly supported by a Ca2+ influx at the site of stimulation (primary response). Excitatory Amino Acids 23-45 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 168-171 1351266-3 1992 Local stimulation with excitatory amino acids, applied from a microelectrode with 1-2-s iontophoretic pulses at the dendrite, induced a rapid increase in intracellular Ca2+ predominantly supported by a Ca2+ influx at the site of stimulation (primary response). Excitatory Amino Acids 23-45 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 202-205 1351266-0 1992 Persisting modification of dendritic calcium influx by excitatory amino acid stimulation in isolated Ca1 neurons. Excitatory Amino Acids 55-76 carbonic anhydrase 1 Cavia porcellus 101-104 1351266-5 1992 In the remaining neurons the initial exposure to excitatory amino acids induced a non-recovering gradient of Ca2+, highest at the site of stimulation, that lasted for periods of minutes (secondary response). Excitatory Amino Acids 49-71 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 109-112 1351266-12 1992 K depolarization applied after excitatory amino acid stimulation produced larger Ca2+ changes than the same K stimulus applied before the cell was stimulated with the excitatory amino acid. Excitatory Amino Acids 31-52 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 81-84 1353619-11 1992 Acetylcholinesterase also enhanced the response of Purkinje cells to the excitatory amino acids glutamate and aspartate thought to be transmitters in the cerebellar cortex. Excitatory Amino Acids 73-95 acetylcholinesterase Cavia porcellus 0-20 1797867-11 1991 These results show that out of the two calcium-binding proteins, CaBP is a characteristic protein of a small subpopulation of neurons using excitatory amino acids and PV is a characteristic protein of a subpopulation of neurons utilizing GABA as a transmitter. Excitatory Amino Acids 140-162 S100 calcium binding protein G Rattus norvegicus 65-69 2066767-4 1991 Intrathecally administered 2-methyl 5-HT produced dose-dependent antinociception in the tail-flick test and inhibited behaviors elicited by intrathecally administered agonists for excitatory amino acid and neurokinin receptors, namely NMDA and substance P (SP). Excitatory Amino Acids 180-201 tachykinin precursor 1 Homo sapiens 244-255 1681831-1 1991 The ability of excitatory amino acids to induce increases in the intracellular Ca2+ concentration ([Ca2+]i) of cerebellar Purkinje cells was examined by digital fluorescence ratio imaging of voltage-clamped Purkinje cells dialyzed with the Ca2+ indicator fura-2. Excitatory Amino Acids 15-37 carbonic anhydrase 2 Homo sapiens 79-82 1681831-1 1991 The ability of excitatory amino acids to induce increases in the intracellular Ca2+ concentration ([Ca2+]i) of cerebellar Purkinje cells was examined by digital fluorescence ratio imaging of voltage-clamped Purkinje cells dialyzed with the Ca2+ indicator fura-2. Excitatory Amino Acids 15-37 carbonic anhydrase 2 Homo sapiens 100-103 1681831-1 1991 The ability of excitatory amino acids to induce increases in the intracellular Ca2+ concentration ([Ca2+]i) of cerebellar Purkinje cells was examined by digital fluorescence ratio imaging of voltage-clamped Purkinje cells dialyzed with the Ca2+ indicator fura-2. Excitatory Amino Acids 15-37 carbonic anhydrase 2 Homo sapiens 100-103 1681831-2 1991 Purkinje cells responded with large inward currents accompanied by increases in dendritic [Ca2+]i when challenged with the excitatory amino acid agonists glutamate and quisqualate. Excitatory Amino Acids 123-144 carbonic anhydrase 2 Homo sapiens 91-94 2051165-9 1991 In conclusion, the postischemic increase of excitatory amino acids and the recovery of the neuronal activity may stress the CA1 pyramidal cells, which could be detrimental in combination with, e.g., postsynaptic impairments. Excitatory Amino Acids 44-66 carbonic anhydrase 1 Rattus norvegicus 124-127 2051166-1 1991 An excessive activation of the excitatory amino acid system has been proposed as one possible mediator of the ischemia-induced delayed death of CA1 pyramidal cells in the hippocampus. Excitatory Amino Acids 31-52 carbonic anhydrase 1 Rattus norvegicus 144-147 12106487-2 1991 We have demonstrated that stimulation of spinal cord or cortical neurons in vitro with excitatory amino acids results in a dramatic modification of the neuronal cytoskeleton as monitored with antibodies against MAP2 and tubulin. Excitatory Amino Acids 87-109 microtubule-associated protein 2 Rattus norvegicus 211-215 1673070-2 1991 A grease-gap technique has been used to measure d.c. potentials, in response to the application of excitatory amino acids and electrical stimulation of the Schaffer collateral-commissural pathway, in the CA1 region of rat hippocampal slices. Excitatory Amino Acids 99-121 carbonic anhydrase 1 Rattus norvegicus 204-207 1886169-3 1991 The present study was undertaken in order to find out if a nonproteic neurotrophic factor like n-hexacosanol may be able to reduce the neuronal damages induced by the excitatory amino acid, kainic acid. Excitatory Amino Acids 167-188 neurotrophin 3 Rattus norvegicus 70-89 1650276-1 1991 Many excitatory amino acid (EAA)-mediated synaptic potentials are dual-component as a result of the simultaneous activation of N-methyl-D-aspartate (NMDA) and non-NMDA receptor subtypes, the two major classes of EAA receptor in vertebrates. Excitatory Amino Acids 5-26 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 163-176 1650276-1 1991 Many excitatory amino acid (EAA)-mediated synaptic potentials are dual-component as a result of the simultaneous activation of N-methyl-D-aspartate (NMDA) and non-NMDA receptor subtypes, the two major classes of EAA receptor in vertebrates. Excitatory Amino Acids 28-31 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 163-176 1676831-3 1991 The K(+)-evoked release of cholecystokinin was found to be significantly increased by the three excitatory amino acid agonists effective against glutamate receptor subtypes. Excitatory Amino Acids 96-117 cholecystokinin Rattus norvegicus 27-42 1851996-11 1991 The finding of differential developmental regulation of the GluR-1, -2, and -3 genes indicates that the receptors they encode may have different influences on synaptic plasticity, neuronal survival, and susceptibility to excitatory amino acid toxicity. Excitatory Amino Acids 221-242 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 60-78 2070260-1 1991 The inhibitory potency of ethanol upon excitatory amino acid induced depolarizations of rat hippocampal CA1 pyramidal cells was assessed in the presence and absence of magnesium (Mg2+) using the grease-gap technique. Excitatory Amino Acids 39-60 carbonic anhydrase 1 Rattus norvegicus 104-107 1978267-1 1990 Methionine sulfoxime (MS) is an inhibitor of glutamine synthetase, an astroglial enzyme believed to be involved in the maintenance of glutamine, a major precursor for neurotransmitter pools of the excitatory amino acids aspartate and glutamate in striatal afferent axon terminals. Excitatory Amino Acids 197-219 glutamate-ammonia ligase Rattus norvegicus 45-65 1709478-0 1991 Adenosine deaminase increases release of excitatory amino acids through a mechanism independent of adenosine depletion. Excitatory Amino Acids 41-63 adenosine deaminase Homo sapiens 0-19 2020389-4 1991 Applications of NA before (up to 60 s) or overlapping the ejection of NMDA decreased the amplitude of the negative CFP induced by the excitatory amino acid. Excitatory Amino Acids 134-155 complement factor properdin Rattus norvegicus 115-118 1837849-0 1991 Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids. Excitatory Amino Acids 119-141 nerve growth factor Rattus norvegicus 30-49 1681466-3 1991 A highly sensitive radioimmunoassay was used to examine the actions of depolarizing agents and excitatory amino acids on the release of endogenous somatostatin-like immunoreactivity from striatal interneurons. Excitatory Amino Acids 95-117 somatostatin Mus musculus 147-159 2207501-0 1990 Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia. Excitatory Amino Acids 65-87 carbonic anhydrase 1 Rattus norvegicus 91-94 1976803-9 1990 Morphine, [Met5]enkephalin (ME) and [D-Ala2,N-Me-Phe4, Gly5-ol]enkephalin (DAMGO) depressed the amplitude of the GABA-mediated synaptic potential by a maximum of 50-65% and had little effect on the excitatory amino acid-mediated synaptic potential. Excitatory Amino Acids 198-219 proenkephalin Rattus norvegicus 63-73 1676174-1 1991 Previous studies have shown that excitatory amino acid agonists or GABAergic antagonists injected into the substantia innominata/lateral preoptic area (SI/LPO) can produce the stimulation of coordinated locomotor activity. Excitatory Amino Acids 33-54 lactoperoxidase Homo sapiens 155-158 1652915-7 1991 The synchronized discharging of the CA3 population is blocked by excitatory amino acid antagonists. Excitatory Amino Acids 65-86 carbonic anhydrase 3 Rattus norvegicus 36-39 12106450-8 1991 To support this hypothesis, we showed that in young rats (i) the CaBP-LI was enhanced in pyramidal neurons when the slice was preincubated in a calcium-free medium, and (ii) CaBP-LI was strongly decreased when the slice was preincubated in a high-calcium medium (5 mM) and when the entry of calcium into the cell was increased by a short application of an excitatory amino acid in the medium. Excitatory Amino Acids 356-377 S100 calcium binding protein G Rattus norvegicus 65-69 12106450-8 1991 To support this hypothesis, we showed that in young rats (i) the CaBP-LI was enhanced in pyramidal neurons when the slice was preincubated in a calcium-free medium, and (ii) CaBP-LI was strongly decreased when the slice was preincubated in a high-calcium medium (5 mM) and when the entry of calcium into the cell was increased by a short application of an excitatory amino acid in the medium. Excitatory Amino Acids 356-377 S100 calcium binding protein G Rattus norvegicus 174-178 2027467-7 1991 Previous studies have demonstrated that in the lateral septal area vasopressin modulates the action of the excitatory amino acid-containing hypocamposeptal fibers, and also plays a role in the maintenance of long term potentiation evoked by fimbria-fornix stimulation. Excitatory Amino Acids 107-128 arginine vasopressin Rattus norvegicus 67-78 2162707-7 1990 The excitatory amino acid antagonists blocked clonic seizures induced by BMI in the dose of 0.224 nmol (approximately CD97) when coinjected into the lateral ventricle. Excitatory Amino Acids 4-25 adhesion G protein-coupled receptor E5 Mus musculus 118-122 2163431-9 1990 Pretreatment of animals with ketamine and MK-801, antagonists of excitatory amino acid transmitters, markedly slowed and decreased the rises in [Ca2+]i. Excitatory Amino Acids 65-86 carbonic anhydrase 2 Rattus norvegicus 145-148 1698246-0 1990 Striatal preprotachykinin and preproenkephalin mRNA levels and the levels of nigral substance P and pallidal Met5-enkephalin depend on corticostriatal axons that use the excitatory amino acid neurotransmitters aspartate and glutamate: quantitative radioimmunocytochemical and in situ hybridization evidence. Excitatory Amino Acids 170-191 tachykinin, precursor 1 Rattus norvegicus 9-25 1698246-0 1990 Striatal preprotachykinin and preproenkephalin mRNA levels and the levels of nigral substance P and pallidal Met5-enkephalin depend on corticostriatal axons that use the excitatory amino acid neurotransmitters aspartate and glutamate: quantitative radioimmunocytochemical and in situ hybridization evidence. Excitatory Amino Acids 170-191 proenkephalin Rattus norvegicus 36-46 1979156-5 1990 Two excitatory amino acid antagonists, D(-)-2-amino-5-phosphonovaleric acid (2APV) and glutamic acid diethyl ester (GDEE), suppressed the responses to Glu and also those to VP. Excitatory Amino Acids 4-25 arginine vasopressin Rattus norvegicus 173-175 2163042-1 1990 The 4 configurational isomers of D-3,4-cyclopropylglutamate (D-CGA) have been synthesized and analyzed for their interactions as excitatory amino acid recognition sites. Excitatory Amino Acids 129-150 chromogranin A Homo sapiens 63-66 2110639-1 1990 The effect of excitatory amino acid stimulation on the cytoskeleton of cultured spinal cord and cortical neurons was monitored with antibodies against microtubule-associated proteins tau and MAP2. Excitatory Amino Acids 14-35 microtubule associated protein 2 Homo sapiens 191-195 2110639-6 1990 In contrast, following stimulation with excitatory amino acids, MAP2-immunoreactivity was associated with filaments which formed a complex network within the cell body. Excitatory Amino Acids 40-62 microtubule associated protein 2 Homo sapiens 64-68 2152870-0 1990 Glutamate receptors of the non-N-methyl-D-aspartic acid type mediate the increase in luteinizing hormone-releasing hormone release by excitatory amino acids in vitro. Excitatory Amino Acids 134-156 gonadotropin releasing hormone 1 Rattus norvegicus 85-122 2322817-4 1990 Unilateral electrolytic or excitatory amino acid induced lesions of the basal forebrain result in reductions of AChE staining in ipsilateral visual cortex, particularly in layers IV and V. Electrolytic or scalpel lesions, placed in white matter underlying dorsal and lateral neocortex to interrupt basal forebrain projections to visual cortex, also reduce AChE staining in visual cortex. Excitatory Amino Acids 27-48 acetylcholinesterase Rattus norvegicus 112-116 2322817-4 1990 Unilateral electrolytic or excitatory amino acid induced lesions of the basal forebrain result in reductions of AChE staining in ipsilateral visual cortex, particularly in layers IV and V. Electrolytic or scalpel lesions, placed in white matter underlying dorsal and lateral neocortex to interrupt basal forebrain projections to visual cortex, also reduce AChE staining in visual cortex. Excitatory Amino Acids 27-48 acetylcholinesterase Rattus norvegicus 356-360 12106022-0 1990 Modulation of VIP-Stimulated cAMP Formation by Excitatory Amino Acids in Mouse Cerebral Cortex. Excitatory Amino Acids 47-69 vasoactive intestinal polypeptide Mus musculus 14-17 12106022-1 1990 We have investigated the modulatory action of excitatory amino acids (EAA) on vasoactive intestinal polypeptide (VIP)-stimulated cAMP formation in mouse cerebral cortical slices. Excitatory Amino Acids 46-68 vasoactive intestinal polypeptide Mus musculus 78-111 12106022-1 1990 We have investigated the modulatory action of excitatory amino acids (EAA) on vasoactive intestinal polypeptide (VIP)-stimulated cAMP formation in mouse cerebral cortical slices. Excitatory Amino Acids 46-68 vasoactive intestinal polypeptide Mus musculus 113-116 12106022-1 1990 We have investigated the modulatory action of excitatory amino acids (EAA) on vasoactive intestinal polypeptide (VIP)-stimulated cAMP formation in mouse cerebral cortical slices. Excitatory Amino Acids 70-73 vasoactive intestinal polypeptide Mus musculus 78-111 12106022-1 1990 We have investigated the modulatory action of excitatory amino acids (EAA) on vasoactive intestinal polypeptide (VIP)-stimulated cAMP formation in mouse cerebral cortical slices. Excitatory Amino Acids 70-73 vasoactive intestinal polypeptide Mus musculus 113-116 12106022-8 1990 Thus, based on this metabotropic action, EAA can be categorized into the following classes: (i) those that potentiate the effect of VIP, such as glutamate, aspartate, kainate and ibotenate; (ii) those that inhibit the effect of VIP, such as l-homocysteate and quisqualate; and (iii) those that are ineffective, such as NMDA and d-homocysteate. Excitatory Amino Acids 41-44 vasoactive intestinal polypeptide Mus musculus 132-135 12106022-8 1990 Thus, based on this metabotropic action, EAA can be categorized into the following classes: (i) those that potentiate the effect of VIP, such as glutamate, aspartate, kainate and ibotenate; (ii) those that inhibit the effect of VIP, such as l-homocysteate and quisqualate; and (iii) those that are ineffective, such as NMDA and d-homocysteate. Excitatory Amino Acids 41-44 vasoactive intestinal polypeptide Mus musculus 228-231 1970137-1 1990 Intrastriatal injection of the excitatory amino acid analogue DL-alpha-aminoadipate (100 micrograms in 2 microliters saline, pH 7.4) into anesthetized rats caused a significant reduction in striatal glutamine synthetase activity in the ipsilateral compared to the contralateral striatum 6 h after the injection. Excitatory Amino Acids 31-52 glutamate-ammonia ligase Rattus norvegicus 199-219 1979999-1 1990 The ability of glutamate and other excitatory amino acids to stimulate prolactin secretion when administered to adult animals is hypothesized to depend on a central site of action in the brain, but there are no data to support this position. Excitatory Amino Acids 35-57 prolactin Rattus norvegicus 71-80 35501783-9 2022 We additionally demonstrate that the calcium concentration in the brain of mice increases upon IRISIN stimulation, followed by an increase in the content of excitatory amino acids and norepinephrine, while Trpc3-/- mice exhibit the reverse effect. Excitatory Amino Acids 157-179 fibronectin type III domain containing 5 Homo sapiens 95-101 34454911-4 2021 Here, Dick and Jeff reflect upon those early halcyon days of EAA research, which, as these six1 Special Issues of Neuropharmacology demonstrate, is very much alive and kicking. Excitatory Amino Acids 61-64 SIX homeobox 1 Homo sapiens 91-95 35276302-4 2022 After cerebral ischemia, the swollen astrocytes, neurons and microglia can activate LRRC8A-dependent VRACs, which may respectively promote the release of excitatory amino acids (EAA), interaction with ionotropic glutamate receptors, and regulating inflammation, suggesting the pleiotropic roles of LRRC8A in swollen brain cells. Excitatory Amino Acids 154-176 leucine rich repeat containing 8 VRAC subunit A Homo sapiens 84-90 35276302-4 2022 After cerebral ischemia, the swollen astrocytes, neurons and microglia can activate LRRC8A-dependent VRACs, which may respectively promote the release of excitatory amino acids (EAA), interaction with ionotropic glutamate receptors, and regulating inflammation, suggesting the pleiotropic roles of LRRC8A in swollen brain cells. Excitatory Amino Acids 178-181 leucine rich repeat containing 8 VRAC subunit A Homo sapiens 84-90