PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2566472-3	1989	Formation of the corresponding pyridine required the presence of an NADPH-generating system and was significantly inhibited by carbon monoxide and metyrapone, indicating the participation of cytochrome P-450.	pyridine	31-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	191-207
2809594-6	1989	The corresponding pyridinium species of MPTP and several of the MPTP analogs inhibited MAO-A competitively with Ki values at micromolar concentrations; in contrast the pyridinium species inhibited MAO-B competitively at considerably higher concentrations (i.e., 100 microM or greater Ki values).	pyridine	18-28	monoamine oxidase A	Homo sapiens	87-92
2809594-6	1989	The corresponding pyridinium species of MPTP and several of the MPTP analogs inhibited MAO-A competitively with Ki values at micromolar concentrations; in contrast the pyridinium species inhibited MAO-B competitively at considerably higher concentrations (i.e., 100 microM or greater Ki values).	pyridine	18-28	monoamine oxidase B	Homo sapiens	197-202
2809594-6	1989	The corresponding pyridinium species of MPTP and several of the MPTP analogs inhibited MAO-A competitively with Ki values at micromolar concentrations; in contrast the pyridinium species inhibited MAO-B competitively at considerably higher concentrations (i.e., 100 microM or greater Ki values).	pyridine	168-178	monoamine oxidase B	Homo sapiens	197-202
3360015-0	1988	Control of pyruvate carboxylase activity by the pyridine-nucleotide redox state in mitochondria from rat liver.	pyridine	48-56	pyruvate carboxylase	Rattus norvegicus	11-31
2908227-0	1988	Synthesis and activity of pyridine analogues of histamine H2-receptor antagonists.	pyridine	26-34	histamine H2 receptor	Cavia porcellus	48-69
3192493-6	1988	Attachment of a pyridinium group to a cephem at C-3 via a thiomethyl or an aminomethyl bridge causes reduction of antibacterial activity.	pyridine	16-26	complement C3	Homo sapiens	48-51
3418515-0	1988	Pyridine induction of cytochrome P-450 in the rat: role of P-450j (alcohol-inducible form) in pyridine N-oxidation.	pyridine	0-8	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	22-38
3418515-0	1988	Pyridine induction of cytochrome P-450 in the rat: role of P-450j (alcohol-inducible form) in pyridine N-oxidation.	pyridine	94-102	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	59-65
3418515-1	1988	Previous research has shown that pyridine (PY) pretreatment of rabbits elevates total hepatic microsomal cytochrome P-450 content in association with the appearance of intense bands in the region of P-450LM4 and LM3 in the electrophoretic pattern of the microsomes and increased rates of PY N-oxide production and N-nitrosodimethylamine, alcohol and aniline metabolism.	pyridine	33-41	cytochrome P-450	Oryctolagus cuniculus	105-121
3418515-1	1988	Previous research has shown that pyridine (PY) pretreatment of rabbits elevates total hepatic microsomal cytochrome P-450 content in association with the appearance of intense bands in the region of P-450LM4 and LM3 in the electrophoretic pattern of the microsomes and increased rates of PY N-oxide production and N-nitrosodimethylamine, alcohol and aniline metabolism.	pyridine	33-41	cytochrome P450 1A2	Oryctolagus cuniculus	199-207
3418515-1	1988	Previous research has shown that pyridine (PY) pretreatment of rabbits elevates total hepatic microsomal cytochrome P-450 content in association with the appearance of intense bands in the region of P-450LM4 and LM3 in the electrophoretic pattern of the microsomes and increased rates of PY N-oxide production and N-nitrosodimethylamine, alcohol and aniline metabolism.	pyridine	43-45	cytochrome P-450	Oryctolagus cuniculus	105-121
3418515-1	1988	Previous research has shown that pyridine (PY) pretreatment of rabbits elevates total hepatic microsomal cytochrome P-450 content in association with the appearance of intense bands in the region of P-450LM4 and LM3 in the electrophoretic pattern of the microsomes and increased rates of PY N-oxide production and N-nitrosodimethylamine, alcohol and aniline metabolism.	pyridine	43-45	cytochrome P450 1A2	Oryctolagus cuniculus	199-207
3137566-7	1988	The data support the conclusion that both 2"-MeMPTP and 2"-EtMPTP are bioactivated to pyridinium species to a significant extent by MAO-A.	pyridine	86-96	monoamine oxidase A	Homo sapiens	132-137
3351862-5	1988	The short duration of pharmacological effect of 3 was attributed to metabolic hydroxylation at the C-4 pyridine methyl group; however, structural modifications designed to inhibit this metabolic pathway were unsuccessful.	pyridine	103-111	complement C4A (Rodgers blood group)	Homo sapiens	99-102
3102600-12	1987	However, when fractionated in pyridine-acetic acid buffer, hNSF activity was distributed in a slightly wider range of 15,000 to 30,000 daltons.	pyridine	30-38	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	59-63
3346205-5	1988	When ADP and Pi were added to the thylakoid suspension after a train of flashes [similar to the traditional post-illumination phosphorylation protocol (termed PIP- here)], the post-illumination ATP yield was influenced by pyridine as expected, in a manner consistent with the ATP formation, in part, being driven by protons present in the bulk inner aqueous phase, i.e., through a delocalized protonmotive force.	pyridine	222-230	prolactin induced protein	Homo sapiens	159-162
3376493-6	1988	The formation of the pyridine analogue required the presence of NADPH-generating system and was significantly inhibited by cytochrome c, metyrapone, and 7,8-benzoflavone, indicating the participation of cytochrome P-450.	pyridine	21-29	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	203-219
3039139-3	1987	The apparent equal receptor binding of 1 and syn-anti isomer indicates that isomerization of the azine moiety may take place under the conditions of biological evaluation.	pyridine	97-102	synemin	Homo sapiens	45-48
3346880-1	1988	Results from previous studies indicate that rabbit liver microsomal cytochrome P-450 catalyzes the C-5" two-electron oxidation of (S)-nicotine stereoselectivity with preferential loss of the pro-(E)-hydrogen atom trans to the pyridine ring.	pyridine	226-234	cytochrome P-450	Oryctolagus cuniculus	68-84
3346880-1	1988	Results from previous studies indicate that rabbit liver microsomal cytochrome P-450 catalyzes the C-5" two-electron oxidation of (S)-nicotine stereoselectivity with preferential loss of the pro-(E)-hydrogen atom trans to the pyridine ring.	pyridine	226-234	complement C5	Oryctolagus cuniculus	99-102
3327676-14	1987	The first step in the metabolism involves oxidation to the corresponding pyridine derivative by the cytochrome P-450 system.	pyridine	73-81	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	100-116
3119503-5	1987	The lyso-PAF fraction obtained was acetylated to PAF chemically with pyridine and acetic anhydride.	pyridine	69-77	PCNA clamp associated factor	Rattus norvegicus	9-12
3119503-5	1987	The lyso-PAF fraction obtained was acetylated to PAF chemically with pyridine and acetic anhydride.	pyridine	69-77	PCNA clamp associated factor	Rattus norvegicus	49-52
3084895-3	1986	This observation adds further support to the concept that the oxidation of MPTP by MAO-B to its corresponding pyridinium analog, 1-methyl-4-phenylpyridinium (MPP+), is an important feature of the neurotoxic process.	pyridine	110-120	monoamine oxidase B	Mus musculus	83-88
3746811-4	1986	The 4-alkyl compounds, in contrast, formed a pyridine derivative in which a hydrogen atom was present at the 4-position and the alkyl group was lost; these compounds also inactivated cytochrome P-450 and caused the loss of nifedipine oxidase activity after enzymatic oxidation.	pyridine	45-53	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	194-199
3746811-4	1986	The 4-alkyl compounds, in contrast, formed a pyridine derivative in which a hydrogen atom was present at the 4-position and the alkyl group was lost; these compounds also inactivated cytochrome P-450 and caused the loss of nifedipine oxidase activity after enzymatic oxidation.	pyridine	45-53	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	223-241
3564801-3	1986	These substituted pyridines gave pyridyl-N-and/or pyridyl-O-substituted derivatives, depending both upon the position of the hydroxyl and methyl groups in the pyridine ring, at the C-4 and the C-6 of the uracil and guanine residues, respectively.	pyridine	18-26	complement C4A (Rodgers blood group)	Homo sapiens	181-184
3564801-3	1986	These substituted pyridines gave pyridyl-N-and/or pyridyl-O-substituted derivatives, depending both upon the position of the hydroxyl and methyl groups in the pyridine ring, at the C-4 and the C-6 of the uracil and guanine residues, respectively.	pyridine	18-26	complement C6	Homo sapiens	193-196
3487620-3	1986	This effect was abolished by pretreatment with pargyline, a MAOB inhibitor, suggesting that oxidation of MPTP to the pyridinium moiety, MPP+, is a necessary step for toxicity when mazindol binding is used as an end point.	pyridine	117-127	monoamine oxidase B	Mus musculus	60-64
3955059-8	1986	Ferrochelatase activity was measured by both the pyridine hemochromogen method and by measurement of zinc protoporphyrin with endogenous zinc as substrate.	pyridine	49-57	ferrochelatase	Rattus norvegicus	0-14
3955059-11	1986	When ferrochelatase activity was measured by pyridine hemochromogen, identical results were observed in iron-deficient and control animals but decreased by 45% in iron-overloaded animals.	pyridine	45-53	ferrochelatase	Rattus norvegicus	5-19
3484542-3	1986	MPTP is oxidized in the brain to a pyridinium species, 1-methyl-4-phenylpyridine (MPP+)6.	pyridine	35-45	protein associated with LIN7 2, MAGUK p55 family member	Homo sapiens	82-88
2417837-2	1986	The analysis of the different NMR parameters suggest that substance P adopts a rather extended structure in dimethylsulfoxide and pyridine.	pyridine	130-138	tachykinin precursor 1	Homo sapiens	58-69
3937555-1	1985	Purified bovine rhodopsin was reductively methylated with formaldehyde and pyridine/borane with the incorporation of approximately 20 methyl groups in the protein.	pyridine	75-83	rhodopsin	Bos taurus	16-25
3935467-3	1985	These data lend further support to the concept that the oxidation of MPTP by MAO-B to its corresponding pyridinium analog, 1-methyl-4-phenyl-pyridinium (MPP+) is an important feature of the neurotoxic process.	pyridine	104-114	monoamine oxidase B	Mus musculus	77-82
4056404-5	1985	From the standard curve obtained by pyridine extraction (Coomassie blue colour yield at A605 nm) the concentration of SAA in the HDL3 standard was determined.	pyridine	36-44	serum amyloid A1	Homo sapiens	118-121
6713388-5	1984	PAI and PAII were extracted using pyridine, which yielded four fractions, i.e., pyridine-extracted strains PAI and PAII (PA-PEI and PA-PEII, respectively) which are composed of the cell wall material extracted by pyridine, and the residues of PA-PEI and PA-PEII (PA-RI and PA-RII, respectively) which are composed of the residue material following the chemical extraction.	pyridine	34-42	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	0-3
3839671-0	1985	Pyridine and imidazole reversibly inhibit the respiratory burst in porcine and human neutrophils: evidence for the involvement of cytochrome b558 in the reaction.	pyridine	0-8	mitochondrially encoded cytochrome b	Homo sapiens	130-142
3839671-2	1985	Inhibition was accompanied by a spectral change in reduced cytochrome b558 as judged by low-temperature spectroscopy at 77 K. The position and shape of the alpha-band of the cytochrome were significantly altered upon exposure to pyridine or some other bases.	pyridine	229-237	mitochondrially encoded cytochrome b	Homo sapiens	59-71
3018063-2	1985	The pyridine cofactors NADPH and NADH, riboflavin, and the nucleosides 2-thiouracil and 4-thiouridine were found to sensitize the transmission of photon energy from solar radiation and monochromatic radiation (290, 334, 365, and 405 nm) to oxygen, resulting in O2- formation, as detected by superoxide dismutase-inhibitable cytochrome c reduction.	pyridine	4-12	cytochrome c, somatic	Homo sapiens	324-336
6146719-1	1984	The furan ring of the histamine H2 receptor antagonist 3-amino-4-[[2-[[[5-[(dimethylamino)methyl]-2-furanyl]-methyl] thio]ethyl]amino]-1,2,5-thiadiazole 1-oxide (1a) was replaced by thiophene, pyridine, benzene, and pyrrole.	pyridine	193-201	histamine receptor H2	Homo sapiens	22-43
3875815-0	1985	Conversion of the neurotoxic precursor 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine into its pyridinium metabolite by human platelet monoamine oxidase type B.	pyridine	93-103	monoamine oxidase B	Homo sapiens	133-157
6331459-5	1984	Since cyclic AMP phosphodiesterase inhibitors are known to enhance glucose-induced insulin secretion and to activate glucose production by the liver, the finding that the pyridine derivatives described here inhibited cyclic AMP phosphodiesterase opens new avenues of interpretation for their insulinotropic action as well as for the paradoxical lack of improvement of glucose disposal by elevation of insulin after oral drug administration.	pyridine	171-179	insulin	Canis lupus familiaris	83-90
6713388-5	1984	PAI and PAII were extracted using pyridine, which yielded four fractions, i.e., pyridine-extracted strains PAI and PAII (PA-PEI and PA-PEII, respectively) which are composed of the cell wall material extracted by pyridine, and the residues of PA-PEI and PA-PEII (PA-RI and PA-RII, respectively) which are composed of the residue material following the chemical extraction.	pyridine	80-88	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	0-3
6713388-5	1984	PAI and PAII were extracted using pyridine, which yielded four fractions, i.e., pyridine-extracted strains PAI and PAII (PA-PEI and PA-PEII, respectively) which are composed of the cell wall material extracted by pyridine, and the residues of PA-PEI and PA-PEII (PA-RI and PA-RII, respectively) which are composed of the residue material following the chemical extraction.	pyridine	80-88	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	8-11
6713388-5	1984	PAI and PAII were extracted using pyridine, which yielded four fractions, i.e., pyridine-extracted strains PAI and PAII (PA-PEI and PA-PEII, respectively) which are composed of the cell wall material extracted by pyridine, and the residues of PA-PEI and PA-PEII (PA-RI and PA-RII, respectively) which are composed of the residue material following the chemical extraction.	pyridine	80-88	PARP1 binding protein	Mus musculus	263-268
6713388-5	1984	PAI and PAII were extracted using pyridine, which yielded four fractions, i.e., pyridine-extracted strains PAI and PAII (PA-PEI and PA-PEII, respectively) which are composed of the cell wall material extracted by pyridine, and the residues of PA-PEI and PA-PEII (PA-RI and PA-RII, respectively) which are composed of the residue material following the chemical extraction.	pyridine	80-88	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	0-3
6713388-5	1984	PAI and PAII were extracted using pyridine, which yielded four fractions, i.e., pyridine-extracted strains PAI and PAII (PA-PEI and PA-PEII, respectively) which are composed of the cell wall material extracted by pyridine, and the residues of PA-PEI and PA-PEII (PA-RI and PA-RII, respectively) which are composed of the residue material following the chemical extraction.	pyridine	80-88	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	8-11
6713388-5	1984	PAI and PAII were extracted using pyridine, which yielded four fractions, i.e., pyridine-extracted strains PAI and PAII (PA-PEI and PA-PEII, respectively) which are composed of the cell wall material extracted by pyridine, and the residues of PA-PEI and PA-PEII (PA-RI and PA-RII, respectively) which are composed of the residue material following the chemical extraction.	pyridine	80-88	PARP1 binding protein	Mus musculus	263-268
6324612-3	1984	The group of beta-endorphin-related peptides is resolved by ion-exchange chromatography on the pyridinium form of sulfopropyl Sephadex C25 in the presence of 50% acetic acid.	pyridine	95-105	proopiomelanocortin	Homo sapiens	13-27
620069-1	1978	Dihydrodesmosine and dihydroisodemosine are dihydropyridines which are believed to be the immediate biosynthetic precursors of desmosine and isodesmosine, the stable pyridinium ion crosslinks of elastin.	pyridine	166-176	elastin	Homo sapiens	195-202
6688177-3	1983	The observation that non-pyridine ligands will maintain the cytochrome P-450 concentration supports this hypothesis.	pyridine	25-33	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	60-76
6262062-4	1981	A variety of inhibitors of ADP-ribosylation reactions besides nicotinamide, most of them pyridine analogues, similarly prevented insulin-induced receptor loss.	pyridine	89-97	insulin	Homo sapiens	129-136
7463039-2	1980	The copper(I) chloride, pyridine system has shown marked tryptophan 2,3-dioxygenase activity with tryptophan and indole derivatives.	pyridine	24-32	tryptophan 2,3-dioxygenase	Homo sapiens	57-83
7437460-7	1980	It is concluded that elastin contains several fluorophores, one of which is a cross-linking tricarboxylic amino acid with a pyridinium ring having very probably the structure of 3-(2-amino-2-carboxyethyl)-1-(5-amino-5-carboxy-2-hydroxy-pentyl)-4-(3-amino-3- carboxypropyl)-5-hydroxypyridinium.	pyridine	124-134	elastin	Homo sapiens	21-28
7406903-0	1980	The relationship between the ability of pyridine and substituted pyridines to maintain cytochrome P-450 and inhibit protein synthesis in rat hepatocyte cultures.	pyridine	40-48	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	87-103
435080-5	1979	The oximes with a hydroxyiminomethyl group in position 4 in the pyridinium ring were good reactivators of both phosphorylated and phosphonylated acetylcholinesterase.	pyridine	64-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	145-165
674296-0	1978	Protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase by fluostigmine.	pyridine	38-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-103
674296-1	1978	The protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase (AChE) by fluostigmine was studied in vitro on human erythrocytes.	pyridine	42-52	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-107
674296-1	1978	The protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase (AChE) by fluostigmine was studied in vitro on human erythrocytes.	pyridine	42-52	acetylcholinesterase (Cartwright blood group)	Homo sapiens	109-113
6658886-2	1983	1H NMR spectra of all four 17 xi-hydroxy/17 xi-methyl C-3 ketones and all eight C-3 alcohols were recorded in chloroform-d and pyridine-d5.	pyridine	127-135	complement C3	Homo sapiens	54-57
6658886-2	1983	1H NMR spectra of all four 17 xi-hydroxy/17 xi-methyl C-3 ketones and all eight C-3 alcohols were recorded in chloroform-d and pyridine-d5.	pyridine	127-135	complement C3	Homo sapiens	80-83
7333280-2	1981	The size of the groups present at C-3 of the pyridinium can be increased quite extensively without loss of coenzyme activity.	pyridine	45-55	complement C3 alpha chain	Oryctolagus cuniculus	34-37
6912069-2	1981	Elastin contains a number of cross-linking amino acid residues such as desmosine and isodesmosine which are primarily hydrophobic in character, but have a positively charged pyridinium ring.	pyridine	174-184	elastin	Homo sapiens	0-7
43840-2	1979	HCl(Asc, aminosuccinyl), which transformed partially to cyclo[Leu-Asp(Phe-NH2)] during its purification by column chromatography on silica gel with a mixture of ethyl acetate/pyridine/acetic acid/water = 60:20:6:11, i.e. in neutral medium.	pyridine	175-183	PYD and CARD domain containing	Homo sapiens	4-7
6467-1	1976	The oxidation-reduction potential, E2, for the couple oxidized lipoamide dehydrogenase/2-electron reduced lipoamide dehydrogenase has been determined by measurement of equilibria of these enzyme species with lipoamide and dihydrolipoamide or with oxidized and reduced azine dyes.	pyridine	268-273	dihydrolipoamide dehydrogenase	Sus scrofa	63-86
404151-7	1977	It is proposed that copper is coordinated to the postulated pyridoxal phosphate of diamine oxidase through the pyridine nitrogen.	pyridine	111-119	amine oxidase copper containing 1	Sus scrofa	83-98
867444-0	1977	Characterization of C-4-methylated sterols by pyridine-induced solvent shifts in proton magnetic resonance spectroscopy.	pyridine	46-54	complement C4A (Rodgers blood group)	Homo sapiens	20-23
320260-0	1977	Inhibition of C1s-induced vascular leakage in guinea pigs by substituted benzamidine and pyridinium compounds.	pyridine	89-99	complement C1s subcomponent	Cavia porcellus	14-17
320260-1	1977	A variety of benzamidine and pyridinium compounds were examined for their ability to inhibit irreversibly C1s-induced vascular leakage in guinea pig skin.	pyridine	29-39	complement C1s subcomponent	Cavia porcellus	106-109
184092-8	1976	The complexes of ferrous leghemoglobin with substituted pyridines exhibit optical absorption maxima near 685 nm, whose absorption maxima and extinctions are strongly dependent on the nature of the substitutents of the pyridine ring; electron withdrawing groups on the pyridine ring shift the absorption maxima to lower energy.	pyridine	56-64	leghemoglobin A	Glycine max	25-38
184092-8	1976	The complexes of ferrous leghemoglobin with substituted pyridines exhibit optical absorption maxima near 685 nm, whose absorption maxima and extinctions are strongly dependent on the nature of the substitutents of the pyridine ring; electron withdrawing groups on the pyridine ring shift the absorption maxima to lower energy.	pyridine	218-226	leghemoglobin A	Glycine max	25-38
6467-1	1976	The oxidation-reduction potential, E2, for the couple oxidized lipoamide dehydrogenase/2-electron reduced lipoamide dehydrogenase has been determined by measurement of equilibria of these enzyme species with lipoamide and dihydrolipoamide or with oxidized and reduced azine dyes.	pyridine	268-273	dihydrolipoamide dehydrogenase	Sus scrofa	106-129
182488-8	1976	This supports the model that one of the pyridine nitrogens of metyrapone is coordinated to the iron of cytochrome P-450.	pyridine	40-48	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-119
178873-3	1976	It has now been shown that the 2,2"-anhydro linkage in 1 and 3 can be selectively and efficiently cleaved by treatment with a mixture of pyridine and methanol giving the corresponding 3"-O-acyl derivatives of 1-beta-D-arabinofuranosylcytosine (2,4).	pyridine	137-145	inversion, Chr 17	Mus musculus	52-62
931984-8	1976	Purified pulmonary cytochrome P-450 formed typical types I and II substrate difference spectra with benzphetamine and pyridine, respectively.	pyridine	118-126	cytochrome P-450	Oryctolagus cuniculus	19-35
1036947-3	1976	In this case the formal insertion of an ethylenic double bond between the pyridinium ring and the aldoxime group decreases the ability to reactivate phosphorylated acetylcholinesterase (AChE).	pyridine	74-84	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-184
1036947-3	1976	In this case the formal insertion of an ethylenic double bond between the pyridinium ring and the aldoxime group decreases the ability to reactivate phosphorylated acetylcholinesterase (AChE).	pyridine	74-84	acetylcholinesterase (Cartwright blood group)	Homo sapiens	186-190
16591729-5	1969	Further evidence for the cyclic structure is given by the identification of 2,2,5-trimethyltetrahydrofuran (VIII) from the action of pyridine and lithium chloride on the 1,2,2,5-tetramethyltetrahydrofuranium salt IIb.	pyridine	133-141	cytochrome c oxidase subunit 8A	Homo sapiens	108-112
1237459-2	1975	A) Via complete reaction of A-chain from bovine insulin with 150 equivalents of phenylisothiocyanate in pyridine/water and trifluoroacetic acid cleavage of the resulting phenylthiocarbamoyl A-chain.	pyridine	104-112	insulin	Bos taurus	48-55
5438017-0	1970	A direct proton magnetic resonance study of Co2+ complexes with imidazole, 4-methylpyridine, pyridine, pyrimidine, and purine in water-acetone mixtures.	pyridine	83-91	complement C2	Homo sapiens	44-47
4980309-2	1969	beta-N-Acetyl-glucosaminidase and beta-galactosidase were removed from the preparation by treatment with pyridine.	pyridine	105-113	galactosidase, beta 1	Rattus norvegicus	34-52
14346090-2	1965	Pseudomonas cytochrome c-551 was modified by treatment at 20 degrees with glyoxylate in the presence of pyridine and cupric sulphate.	pyridine	104-112	cytochrome c, somatic	Homo sapiens	12-24
19873017-12	1937	Hydrazine or pyridine and hydrosulfite convert catalase into hemochromogens containing ferrous iron.	pyridine	13-21	catalase	Homo sapiens	47-55
13479489-0	1957	[Dissociation of insulin in pyridine-water and acetic acid-water solutions].	pyridine	28-36	insulin	Homo sapiens	17-24
34015802-4	2021	This reactivity provides a mechanistically alternative tactic for sp2 carbon-boron bond assembly where the elementary steps of transition-metal mediated C-H activation and reductive elimination from azine-organometallic intermediates are replaced with a direct, Minisci9-style, radical addition.	pyridine	199-204	Sp2 transcription factor	Homo sapiens	66-69
33930844-6	2021	Subsequent derivatization of a pyridine derivative led to the discovery of a pyrimidine derivative, 33g, which selectively inhibited the activity of Axl over Mer without retinal toxicity at a dose of 100 mg/kg in mice.	pyridine	31-39	AXL receptor tyrosine kinase	Mus musculus	149-152
33934190-3	2021	Herein, an aggregation-induced emission (AIE) probe CSP, by introducing a pyridinium cation as the mitochondria-targeted group to an AIE active core cyanostilbene skeleton, is highly sensitive to viscosity changes due to the restriction of intramolecular motion (RIM) and inhibition of twisted intramolecular charge transfer (TICT) in high-viscosity systems.	pyridine	74-84	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	52-55
34036731-0	2021	Novel pyridine-containing sultones: Structure-activity relationship and biological evaluation as selective AChE inhibitors for the treatment of Alzheimer"s disease.	pyridine	6-14	acetylcholinesterase	Mus musculus	107-111
34036731-3	2021	The structure-activity relationship (SAR) showed: (i) fused pyridine-containing sultones increased the AChE inhibition, series B > series A ; (ii) series B with halo-phenyl had better activity.	pyridine	60-68	acetylcholinesterase	Mus musculus	103-107
33903874-2	2021	[Co(NCS)2(4-(3-phenylpropyl)pyridine)2]n is ferromagnetic with Tc = 3.39 K. Single-ion ab initio calculations predict an almost Ising-type magnetic anisotropy and the direction of the magnetic easy-axis nearly along the Co-Npy bond of the apical pyridine-based co-ligand.	pyridine	28-36	cytosolic thiouridylase subunit 2	Homo sapiens	4-9
33948983-0	2021	Pyridine-derived VEGFR-2 inhibitors: Rational design, synthesis, anticancer evaluations, in silico ADMET profile, and molecular docking.	pyridine	0-8	kinase insert domain receptor	Homo sapiens	17-24
33844523-3	2021	Selective poisoning studies with pyridine show that ~90% of the Ni(PAr3)(codH)+ sites in this material are active in polymerization reactions.	pyridine	33-41	par-3 family cell polarity regulator	Homo sapiens	67-71
33991570-3	2021	Herein, we explored the potential inhibitory activities of various pyridine, quinoxaline, and triazine derivatives (3a-k, 6a-j and 11a-h) against AChE and BuChE enzymes by following the modified Ellman"s method.	pyridine	67-75	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-150
33620767-2	2021	Herein, we report that, instead of using traditional encapsulation-driven processes, steric hindrance in metal coordination on the outer surface of Rh(II)-Based Metal Organic Polyhedra (Rh-MOPs) can be used to separate pyridine-based regioisomers via liquid-liquid extraction.	pyridine	219-227	Rh blood group D antigen	Homo sapiens	148-154
33948983-1	2021	Novel pyridine-derived compounds (5-19) were designed and synthesized, and their anticancer activities were evaluated against HepG2 and MCF-7 cells, targeting the VEGFR-2 enzyme.	pyridine	6-14	kinase insert domain receptor	Homo sapiens	163-170
33607042-4	2021	ALOX12B-/- stratum corneum contained abundant pyridine-extractable (i.e., unbound) CLEs, compared to normal stratum corneum.	pyridine	46-54	arachidonate 12-lipoxygenase, 12R type	Mus musculus	0-7
33571827-4	2021	Herein we detail the discovery of a series of novel pyridine-derived CDK8 inhibitors.	pyridine	52-60	cyclin dependent kinase 8	Homo sapiens	69-73
33896285-6	2021	We found that the highly active LTA4H inhibitors mostly contained diphenylmethane or diphenyl ether as the scaffold and pyridine or piperidine as the side chain.	pyridine	120-128	leukotriene A4 hydrolase	Homo sapiens	32-37
33631656-1	2021	Herein we report simple pyridinium (1-3) and quinolinium (4) salts for the selective recognition of G-quadruplexes (G4s).	pyridine	24-34	arylsulfatase B	Homo sapiens	116-119
33910228-0	2021	Phosphorus-mediated sp2-sp3 couplings for C-H fluoroalkylation of azines.	pyridine	66-72	Sp2 transcription factor	Homo sapiens	20-23
33910228-0	2021	Phosphorus-mediated sp2-sp3 couplings for C-H fluoroalkylation of azines.	pyridine	66-72	Sp3 transcription factor	Homo sapiens	24-27
33908562-6	2021	Furthermore, two structural variants of NG1, namely, NG2 and NG3, were synthesized, which suggest the crucial role of pyridine in imparting panchromatic emission properties and of both pyridine and acyl-thiourea side chain in the binding of Cu2+ ions.	pyridine	118-126	interleukin 19	Homo sapiens	40-43
33908562-6	2021	Furthermore, two structural variants of NG1, namely, NG2 and NG3, were synthesized, which suggest the crucial role of pyridine in imparting panchromatic emission properties and of both pyridine and acyl-thiourea side chain in the binding of Cu2+ ions.	pyridine	118-126	chondroitin sulfate proteoglycan 4	Homo sapiens	53-56
33908562-6	2021	Furthermore, two structural variants of NG1, namely, NG2 and NG3, were synthesized, which suggest the crucial role of pyridine in imparting panchromatic emission properties and of both pyridine and acyl-thiourea side chain in the binding of Cu2+ ions.	pyridine	118-126	EGF like domain multiple 8	Homo sapiens	61-64
33908562-6	2021	Furthermore, two structural variants of NG1, namely, NG2 and NG3, were synthesized, which suggest the crucial role of pyridine in imparting panchromatic emission properties and of both pyridine and acyl-thiourea side chain in the binding of Cu2+ ions.	pyridine	185-193	interleukin 19	Homo sapiens	40-43
33855812-0	2021	Pyridine grafted on SnO2-loaded carbon nanotubes acting as cocatalyst for highly efficient electroreduction of CO2.	pyridine	0-8	strawberry notch homolog 1	Homo sapiens	20-23
33855812-3	2021	Herein, the grafted pyridine is innovatively coupled with SnO 2 to construct an organic-inorganic composite (SnO 2 /Py-CNTO) for highly efficient CO 2 ER.	pyridine	20-28	strawberry notch homolog 1	Homo sapiens	58-61
33855812-4	2021	The detailed studies show that pyridine and protonated pyridine coexist on the surface of SnO 2 /Py-CNTO, and both play distinctive roles in promoting the selectivity of CO 2 ER.	pyridine	31-39	strawberry notch homolog 1	Homo sapiens	90-93
33855812-4	2021	The detailed studies show that pyridine and protonated pyridine coexist on the surface of SnO 2 /Py-CNTO, and both play distinctive roles in promoting the selectivity of CO 2 ER.	pyridine	55-63	strawberry notch homolog 1	Homo sapiens	90-93
33387804-0	2021	Molecular binding interaction of pyridinium based gemini surfactants with bovine serum albumin: Insights from physicochemical, multispectroscopic, and computational analysis.	pyridine	33-43	albumin	Homo sapiens	81-94
33671544-3	2021	In this work, two kinds of basic pyridine-based organo-catalysts were used to efficiently catalyze phospha-Michael addition reactions, the 4-N,N-dimethylaminopyridinium saccharinate (DMAP Hsac) salt and a fluorous long-chained pyridine (4-Rf-CH2OCH2-py, where Rf = C11F23).	pyridine	33-41	adenylate cyclase 10	Homo sapiens	188-192
33400327-4	2021	However, its reaction with the pyridine-based linkers 4,4   -bipyridine ( L2 ), 1,2-di(4-pyridyl)ethylene ( L3 ) and 1,2-di(4-pyridyl)ethyne ( L4 ) allowed the formation of the 2D polymers [{( h 2 - 1 )Ag} 2 ( micro , Lx ) 3 ] n [TEF] 2n ( Lx = L2 ( 5 ), L3 ( 6 ), L4 ( 7 )), respectively.	pyridine	31-39	immunoglobulin kappa variable 3D-7	Homo sapiens	245-273
33624498-2	2021	Post modification of the pyridine unit in the covalent organic framework (COF) via the formation of pyridinium salts with the chiral bromoacetate led to the chiral ionic COF with OCIL "immobilized", which was utilized as a heterogeneous catalyst for asymmetric Henry reactions with high yield and excellent stereoselectivity.	pyridine	25-33	C-type lectin domain family 2 member D	Homo sapiens	179-183
33638151-1	2021	We detail here distinctive departures from lead classical cholinesterase reactivators, the pyridinium aldoximes, to achieve rapid CNS penetration and reactivation of AChE in the CNS (brain and spinal cord).	pyridine	91-101	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-72
33638151-1	2021	We detail here distinctive departures from lead classical cholinesterase reactivators, the pyridinium aldoximes, to achieve rapid CNS penetration and reactivation of AChE in the CNS (brain and spinal cord).	pyridine	91-101	acetylcholinesterase (Cartwright blood group)	Homo sapiens	166-170
33522547-5	2021	When compared with pure Bi2MoO6 and CdS, the 0.65-Bi2MoO6/CdS composite shows the highest photocatalytic activity for pyridine degradation.	pyridine	118-126	CDP-diacylglycerol synthase 1	Homo sapiens	36-39
33522547-5	2021	When compared with pure Bi2MoO6 and CdS, the 0.65-Bi2MoO6/CdS composite shows the highest photocatalytic activity for pyridine degradation.	pyridine	118-126	CDP-diacylglycerol synthase 1	Homo sapiens	58-61
33637718-3	2021	2,5-Dihydroxypyridine dioxygenase (NicX) from Pseudomonas putida KT2440 uses a mononuclear nonheme Fe(II) to catalyze the oxidative pyridine ring cleavage reaction by transforming DHP into N-formylmaleamic acid (NFM).	pyridine	13-21	2,5-dihydroxypyridine 5,6-dioxygenase	Pseudomonas putida KT2440	35-39
33671544-3	2021	In this work, two kinds of basic pyridine-based organo-catalysts were used to efficiently catalyze phospha-Michael addition reactions, the 4-N,N-dimethylaminopyridinium saccharinate (DMAP Hsac) salt and a fluorous long-chained pyridine (4-Rf-CH2OCH2-py, where Rf = C11F23).	pyridine	227-235	adenylate cyclase 10	Homo sapiens	188-192
33522547-8	2021	Combined with a series of characterisation results, the improvement in pyridine degradation activity was mainly attributed to (1) the S-scheme HJ structure between Bi2MoO6 and CdS, which greatly promoted the separation of photogenerated electrons and holes while retaining its strong redox ability, (2) the large specific surface area, which provided abundant active sites and efficient adsorption performance and catalytic performance, and (3) the special morphology, which induced multiple reflections of light, thereby improving absorption and utilisation of light.	pyridine	71-79	CDP-diacylglycerol synthase 1	Homo sapiens	176-179
33671544-9	2021	To our knowledge, these are good examples of the application of recoverable organo-catalysts to the DMAP Hsac adduct by using non-polar solvent and a fluorous long-chained pyridine under the thermomorphic mode in phospha-Michael addition reactions.	pyridine	172-180	adenylate cyclase 10	Homo sapiens	105-109
33475363-1	2021	In this work, we explore the interfacial properties of the C60-Py@MAPbI3 heterojunction of the PbI-terminated MAPbI3(001) surface and pyridine-functionalized C60-Py fullerene derivative through both collinear and noncollinear density functional theory calculations with and without spin-orbit coupling (SOC) effects.	pyridine	134-142	spindlin 1	Homo sapiens	282-286
33387904-3	2021	In this study, we designed and synthesized a class of halogenated vinyl sulfones by inserting halogens and pyridine to maximize Nrf2 activation efficacy.	pyridine	107-115	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-132
33644006-2	2020	These in silico docking results of quinoline and pyridine substrates, with TDO, also provided support for the postulated cis-dihydroxylation of electron-deficient pyridyl rings, to give transient cis-dihydrodiol intermediates and the derived hydroxyquinolines.	pyridine	49-57	tryptophan 2,3-dioxygenase	Homo sapiens	75-78
33533255-2	2021	Renewed Insights into Fluxionality of the Rhenium Polyhydride Complex ReH5(PPh3)2(Pyridine).	pyridine	82-90	caveolin 1	Homo sapiens	75-79
33533255-5	2021	Based on quantum chemical calculations carried out in this work with density functional theory and coupled-cluster theory, two new fluxional mechanisms have been identified for the rhenium polyhydride complex ReH5(PPh3)2(pyridine) to jointly account for two consecutive coalescence events in the variable-temperature NMR spectra upon heating: lateral and basal three-arm turnstile rotation.	pyridine	221-229	caveolin 1	Homo sapiens	214-218
33533255-6	2021	The frequently cited pseudorotation in ReH5(PPh3)2(pyridine) (Lee et al.	pyridine	51-59	caveolin 1	Homo sapiens	44-48
33476158-1	2021	Relativistic density functional theory has been employed to characterize [AnO2(L)]0/-1 complexes, where An = U, Np, Pu, and Am, and L is the recently reported hexa-aza porphyrin analogue, termed dipyriamethyrin, which contains six nitrogen donor atoms (four pyrrolic and two pyridine rings).	pyridine	275-283	anoctamin 2	Homo sapiens	74-78
33538660-3	2021	METHOD: We developed a new series of rhodacyanine-based Hsp70 inhibitors, represented by compounds 1 and 6, in which the cationic pyridin-1-ium or thiazol-3-ium ring of existing Hsp70 inhibitors (e.g., JG-40 and JG-98) was replaced by a corresponding benzo-fused N-heterocycle.	pyridine	130-143	heat shock protein family A (Hsp70) member 4	Homo sapiens	56-61
33538660-3	2021	METHOD: We developed a new series of rhodacyanine-based Hsp70 inhibitors, represented by compounds 1 and 6, in which the cationic pyridin-1-ium or thiazol-3-ium ring of existing Hsp70 inhibitors (e.g., JG-40 and JG-98) was replaced by a corresponding benzo-fused N-heterocycle.	pyridine	130-143	heat shock protein family A (Hsp70) member 4	Homo sapiens	178-183
33422910-2	2021	In this study, drug repurposing strategies were followed to repositioning of a series of B-RAF V600E imidazol-5-yl pyridine inhibitors to inhibit P38alpha kinase.	pyridine	115-123	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	89-94
33448063-1	2021	A rotating phenyl ring is introduced between the two pyridinium rings, namely, 1,1"-bis[3-(trimethylamonium)propyl]-4,4"-(1,4-phenylene)bispyridinium tetrachloride ((APBPy)Cl4 ), to form a switchable conjugation.	pyridine	53-63	endogenous retrovirus group W member 3	Homo sapiens	172-175
33444019-0	2021	Reactivity Trends in the Gas-Phase Addition of Acetylene to the N-Protonated Aryl Radical Cations of Pyridine, Aniline, and Benzonitrile.	pyridine	101-109	gastrin	Homo sapiens	25-28
33444019-4	2021	This paper investigates the gas-phase ion-molecule reactions of acetylene with nine aromatic distonic sigma-type radical cations derived from pyridinium (Pyr), anilinium (Anl), and benzonitrilium (Bzn) ions.	pyridine	142-152	gastrin	Homo sapiens	28-31
33422910-2	2021	In this study, drug repurposing strategies were followed to repositioning of a series of B-RAF V600E imidazol-5-yl pyridine inhibitors to inhibit P38alpha kinase.	pyridine	115-123	mitogen-activated protein kinase 14	Homo sapiens	146-154
32834115-5	2021	Our Structural and physico-chemical interpretation (SPCI) analysis suggested that heterocyclic nucleus like diazole, furan and pyridine have clear positive contribution while, thiophen, thiazole and pyrimidine may exhibit negative contribution to the SARS-CoV Mpro inhibition.	pyridine	127-135	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	260-264
33321420-4	2021	We have employed recombinant human NAD kinase expressed in E. coli as an enzymatic reagent to convert readily available synthetic NAD derivatives to NADP analogs, which were subsequently transformed into NAADP derivatives using enzyme catalyzed pyridine base exchange.	pyridine	245-253	NAD kinase	Homo sapiens	35-45
33181479-0	2020	Syntheses and anti-HIV and human cluster of differentiation 4 (CD4) down-modulating potencies of pyridine-fused cyclotriazadisulfonamide (CADA) compounds.	pyridine	97-105	CD4 molecule	Homo sapiens	63-66
33350995-2	2021	CP 1 and CP 2 display new two-dimensional double-layered honeycomb frameworks containing uncoordinated nitrogen atoms from pyridine and tetrazole rings, which can easily form hydrogen bonds with various analytes.	pyridine	123-131	ceruloplasmin	Homo sapiens	9-13
32838724-4	2021	<P> Methods: Molecular modeling was used to test the binding affinity of four new unsymmetrical azines to a model of an apoptosis inhibitor protein (XIAP).	pyridine	96-102	X-linked inhibitor of apoptosis	Homo sapiens	149-153
33263407-3	2020	Attempts to access the three-coordinate aluminyl by abstraction of pyridine with BF3 Et2O unexpectedly led to a B/Al metathesis with the preservation of the pincer structure in the product (PBP)Rh(CO)2.	pyridine	67-75	dedicator of cytokinesis 3	Homo sapiens	190-193
33438568-0	2021	Multi-Component Reactions of Cyclohexan-1,3-dione: Synthesis of Fused Pyran, Pyridine, Thiophene and Pyrazole Derivatives with c-Met, AntiProliferative Activities.	pyridine	77-85	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	127-132
33351628-0	2021	Redox-Neutral Cobalt(III)-Catalyzed C-H Activation/Annulation of alpha,beta-Unsaturated Oxime Ether with Alkyne: One-Step Access to Multisubstituted Pyridine.	pyridine	149-157	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	21-24
33180075-5	2020	This study describes a very rare case of a Co(ii) single ion magnet (SIM) that is purely tetrahedrally coordinated by pyridine like ligands.	pyridine	118-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
32700406-5	2020	Here, we incorporate catalysis in an artificial fuel-driven out-of-equilibrium CRN, where the forward (ester formation) and backward reaction (ester hydrolysis) are controlled by varying the ratio of two organocatalysts: pyridine and imidazole.	pyridine	221-229	crooked neck pre-mRNA splicing factor 1	Homo sapiens	79-82
33124828-2	2020	The synthetic scheme utilizes a highly efficient, one-pot protocol for simultaneous construction of the GH-ring system, promoted by HF/pyridine.	pyridine	135-143	gamma-glutamyl hydrolase	Homo sapiens	104-106
33164507-0	2020	Crystal Size Effect on the Spin-Crossover Behavior of {Fe(py)2[Pt(CN)4]} (py = Pyridine) Monitored by Raman Spectroscopy.	pyridine	79-87	spindlin 1	Homo sapiens	27-31
33164507-2	2020	Using variable-temperature Raman spectroscopy, we investigated changes in the temperature-driven spin-transition property of {Fe(py)2[Pt(CN)4]} (py = pyridine) induced by a size reduction from a bulk polycrystalline powder to an ultrathin film (crystallite size, 15 nm).	pyridine	150-158	spindlin 1	Homo sapiens	97-101
32415672-3	2020	A series of pyridine-based POP nanotraps, POP-Py, POP-pNH2-Py, and POP-oNH2-Py, have been rationally designed and systematically explored for the capture of palladium, one of the most utilized PGEs.	pyridine	12-20	phosphatidylinositol glycan anchor biosynthesis class T	Homo sapiens	54-58
32713342-0	2021	Design, Synthesis and invitro biological evaluation of Pyridine,thiadazole, Benzimidazole and Acetyl thiophneAnalogues as Anti tubercular Agents Targeting enzyme InhA.	pyridine	55-63	inhibin subunit alpha	Homo sapiens	162-166
32889383-0	2020	Selective VEGFR-2 inhibitors: Synthesis of pyridine derivatives, cytotoxicity and apoptosis induction profiling.	pyridine	43-51	kinase insert domain receptor	Homo sapiens	10-17
32787079-2	2020	As part of our medicinal chemistry program, we have recently identified the pyridine-based CB2 PET radioligand [18F]3 with a binding affinity (Ki) of 6 nM for CB2 and a selectivity factor of 696 over the cannabinoid receptor type 1 (CB1).	pyridine	76-84	cannabinoid receptor 2	Rattus norvegicus	91-94
32787079-2	2020	As part of our medicinal chemistry program, we have recently identified the pyridine-based CB2 PET radioligand [18F]3 with a binding affinity (Ki) of 6 nM for CB2 and a selectivity factor of 696 over the cannabinoid receptor type 1 (CB1).	pyridine	76-84	cannabinoid receptor 2	Rattus norvegicus	159-162
32787079-2	2020	As part of our medicinal chemistry program, we have recently identified the pyridine-based CB2 PET radioligand [18F]3 with a binding affinity (Ki) of 6 nM for CB2 and a selectivity factor of 696 over the cannabinoid receptor type 1 (CB1).	pyridine	76-84	cannabinoid receptor 1	Rattus norvegicus	233-236
32787118-2	2020	Solvent and pyridine regulation have been proved to be two effective ways to control and tune the supramolecular structure of MT-4 at interfaces.	pyridine	12-20	metallothionein 4	Homo sapiens	126-130
32945294-1	2020	A highly luminescent non-palindromic [(C^C^N)Pd] pincer complex forms upon reacting pyridine-substituted 2,2"-diiodo-biphenyl with [Pd(PPh3)4].	pyridine	84-92	caveolin 1	Homo sapiens	135-139
32745758-4	2020	In this study, structural modification moved beyond side chains on the C(6)-position and reached to pyridine ring itself.	pyridine	100-108	complement component 6	Mus musculus	71-75
32755678-9	2020	A molecular docking study was executed to shed light on the supposed binding mode of the lead compound, STCY1, into the selective pocket of SIRT2 by interaction of the nitrogen of pyridine ring of the compound and Ala135 of the protein.	pyridine	180-188	sirtuin 2	Homo sapiens	140-145
32787083-5	2020	Modest structural changes to the C-3, C-4, and C-5 position substituents of the core pyridine ring afforded compounds M4K2009, M4K2117, and M4K2163, each with a superior potency, selectivity, and/or blood-brain barrier (BBB) penetration profile.	pyridine	85-93	complement C3	Homo sapiens	33-36
32787083-5	2020	Modest structural changes to the C-3, C-4, and C-5 position substituents of the core pyridine ring afforded compounds M4K2009, M4K2117, and M4K2163, each with a superior potency, selectivity, and/or blood-brain barrier (BBB) penetration profile.	pyridine	85-93	complement C4A (Rodgers blood group)	Homo sapiens	38-41
32787083-5	2020	Modest structural changes to the C-3, C-4, and C-5 position substituents of the core pyridine ring afforded compounds M4K2009, M4K2117, and M4K2163, each with a superior potency, selectivity, and/or blood-brain barrier (BBB) penetration profile.	pyridine	85-93	complement C5	Homo sapiens	47-50
31612791-5	2020	The representative poses generated from dynamics simulations compared with NMR data revealed: (i) Pyridoclax bound to P1 and P2 pockets of Mcl-1 BH3 binding groove through its styryl and methyl groups establishing mainly hydrophobic contacts, (ii) one of the ending pyridines interacts through electrostatic interaction with K234 side chain, a negatively charged residue present only in this position in Mcl-1.	pyridine	266-275	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	139-144
32622215-6	2020	The present study showed that the nature of pyridine-based bridging ligand (L) in dinuclear [{Pd(en)Cl}2(mu-L)]2+ complex has an influence on the complex preference for the cytotoxic activity and CT-DNA/BSA (CT-DNA is calf thymus DNA and BSA is bovine serum albumin) binding affinity.	pyridine	44-52	albumin	Bos taurus	203-206
32622215-6	2020	The present study showed that the nature of pyridine-based bridging ligand (L) in dinuclear [{Pd(en)Cl}2(mu-L)]2+ complex has an influence on the complex preference for the cytotoxic activity and CT-DNA/BSA (CT-DNA is calf thymus DNA and BSA is bovine serum albumin) binding affinity.	pyridine	44-52	albumin	Bos taurus	238-241
32622215-6	2020	The present study showed that the nature of pyridine-based bridging ligand (L) in dinuclear [{Pd(en)Cl}2(mu-L)]2+ complex has an influence on the complex preference for the cytotoxic activity and CT-DNA/BSA (CT-DNA is calf thymus DNA and BSA is bovine serum albumin) binding affinity.	pyridine	44-52	albumin	Bos taurus	258-265
32854311-8	2020	Pyridine substitution reduced KOR affinity.	pyridine	0-8	opioid receptor kappa 1	Homo sapiens	30-33
32583226-1	2020	The potential chemotherapeutic properties coupled to photochemical transitions make the family of fac-[Re(CO)3(N,N)X]0/+ (N,N = a bidentate diimine such as 2,2"-bipyridine (bpy); X = halide, H2O, pyridine derivatives, PR3, etc.)	pyridine	163-171	proteinase 3	Homo sapiens	218-221
32713342-4	2021	METHODS: Thus, a series of Pyridine, Thiadiazole, Benzimidazole; and Acetyl thiophene based molecules were designed and docked against crucial mtb enzyme target InhA (Enoyl Acyl Carrier Protein Reductase) Enzyme.	pyridine	27-35	inhibin subunit alpha	Homo sapiens	161-165
32450042-1	2020	The photochemical products of dinucleotides 5"-TpG/5"-GpT with a photoactivatable anticancer Pt(IV) complex (trans,trans,trans-[Pt(N3)2(OH)2(py)2], py = pyridine; 1) were characterized by electrospray ionization mass spectrometry.	pyridine	153-161	glutamic--pyruvic transaminase	Homo sapiens	54-57
32603110-2	2020	The barriers and reaction energies of the SN2 reactions of the oxidized species with pyridine were also studied with a view to identifying species with both low oxidation potentials and low SN2 barriers, so as to broaden the functional group tolerance of in situ electrochemical methylation compared with TEMPO-Me (1-methoxy-2,2,6,6-tetramethylpiperidine).	pyridine	85-93	solute carrier family 38 member 5	Homo sapiens	42-45
32832018-3	2020	The highest hH2R affinities in radioligand competition binding assays were obtained in the case of pyridinium labeled antagonists 19-21 (pK i: 7.71-7.76) and cyanine labeled antagonists 23 and 25 (pK i: 7.67, 7.11).	pyridine	99-109	histamine receptor H2	Homo sapiens	12-16
32413625-3	2020	The current study reports a series of pyridine based synthetic analogues for their alpha-glucosidase inhibitory potential assessed by in vitro, kinetics and in silico studies.	pyridine	38-46	sucrase-isomaltase	Homo sapiens	83-100
32453572-9	2020	Complexation with HCN remains endothermic in water, although less so and the exothermicity of pnicogen bond formation with pyridine is enhanced by solvation.	pyridine	123-131	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	18-21
32380342-0	2020	Design, synthesis and biological evaluation of pyridine derivatives as selective SHP2 inhibitors.	pyridine	47-55	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	81-85
32380342-5	2020	In this study, based on the known inhibitor 1 (SHP099), novel SHP2 inhibitors were designed by means of scaffold hopping, and 35 pyridine derivatives as SHP2 inhibitors were found.	pyridine	129-137	protein phosphatase 1, regulatory inhibitor subunit 1A	Mus musculus	34-45
32380342-5	2020	In this study, based on the known inhibitor 1 (SHP099), novel SHP2 inhibitors were designed by means of scaffold hopping, and 35 pyridine derivatives as SHP2 inhibitors were found.	pyridine	129-137	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	62-66
32380342-5	2020	In this study, based on the known inhibitor 1 (SHP099), novel SHP2 inhibitors were designed by means of scaffold hopping, and 35 pyridine derivatives as SHP2 inhibitors were found.	pyridine	129-137	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	153-157
32380342-12	2020	In brief, this study reported for the first time that pyridine derivatives as novel SHP2 inhibitors had good inhibitory activity and selectivity, providing new clues for the development of small molecule SHP2 inhibitors.	pyridine	54-62	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	84-88
32380342-12	2020	In brief, this study reported for the first time that pyridine derivatives as novel SHP2 inhibitors had good inhibitory activity and selectivity, providing new clues for the development of small molecule SHP2 inhibitors.	pyridine	54-62	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	204-208
32170827-4	2020	As another example, oxidation of 10-10"-linked bis-pyridine-coordinated CoIII corrole dimer with DDQ produced a cobalt corrole radical dimer and a doubly-linked corrole dimer both as stable compounds bearing pyridine and cyanide axial ligands.	pyridine	51-59	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	72-77
32451633-2	2020	The comparative study of optoelectronic properties indicates that thiadiazole with pyridine units containing molecules (M6b) exhibit lower energy of highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy levels than those of oxadiazole and pyridine containing units (M6b).	pyridine	83-91	glycoprotein M6B	Homo sapiens	120-123
32383891-3	2020	The reaction features wide functional group tolerance under mild conditions, highlighted by the tolerance of various aromatic halide (-Cl, -Br, -I) and heteroaromatic rings (pyridine and pyrazine).	pyridine	174-182	integral membrane protein 2B	Homo sapiens	139-146
32420740-6	2020	The calculated results rationalize the experimentally observed enantio- and regioselectivities, and reveal that enantioselectivity of the reaction originates from the hydrogen bond interaction between TRIP and the N-H group of the carbon-centered radical, and the regioselectivity arises from the electron-withdrawing inductive effect from protonated N-atom and intramolecular hydrogen bond interaction between the acetylamino group and the protonated pyridine ring.	pyridine	452-460	TRAF interacting protein	Homo sapiens	201-205
32409804-2	2020	An unprecedented rearrangement of 1,2-dihydropyridines (1,2-DHPs), 3CR products, to 2-pyridones in good yields with a broad substrate scope by DDQ-mediated benzylic oxidation via a pyridinium intermediate is reported.	pyridine	181-191	deoxyhypusine synthase	Homo sapiens	60-64
32409804-3	2020	Treatment of the pyridinium intermediate with tert-butyl isocyanide afforded isomerized 1,2-DHPs, analogous to Ritter amides.	pyridine	17-27	deoxyhypusine synthase	Homo sapiens	92-96
32451633-2	2020	The comparative study of optoelectronic properties indicates that thiadiazole with pyridine units containing molecules (M6b) exhibit lower energy of highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy levels than those of oxadiazole and pyridine containing units (M6b).	pyridine	83-91	glycoprotein M6B	Homo sapiens	308-311
32451633-2	2020	The comparative study of optoelectronic properties indicates that thiadiazole with pyridine units containing molecules (M6b) exhibit lower energy of highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy levels than those of oxadiazole and pyridine containing units (M6b).	pyridine	281-289	glycoprotein M6B	Homo sapiens	120-123
32092218-5	2020	As a model, we designed an LBT with a vinyl-pyridine moiety which was used to attach our tag to the protein GB1 in fast and irreversible fashion.	pyridine	44-52	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	108-111
32329338-0	2020	Palladium-Catalyzed C-4 Selective Coupling of 2,4-Dichloropyridines and Synthesis of Pyridine-based Dyes for Live Cell Imaging.	pyridine	85-93	complement C4A (Rodgers blood group)	Homo sapiens	20-23
32329338-2	2020	After further arylation, 21 examples of C-2, C-4 diarylated pyridines with significant photophysical property were obtained, which were applied as pyridine-based dyes into live-cell imaging with good biocompatibility and low toxicity.	pyridine	60-68	complement C2	Homo sapiens	40-43
32329338-2	2020	After further arylation, 21 examples of C-2, C-4 diarylated pyridines with significant photophysical property were obtained, which were applied as pyridine-based dyes into live-cell imaging with good biocompatibility and low toxicity.	pyridine	60-68	complement C4A (Rodgers blood group)	Homo sapiens	45-48
32264675-0	2020	Synthesis of Bi-, Ter- and Quaterpyridinecarboxylates via Propargylisoxazole-Pyridine Rearrangement.	pyridine	77-85	trans-2,3-enoyl-CoA reductase	Homo sapiens	18-21
32550989-4	2020	Among them the pyridine- and tetrazole-containing compound 24 has significantly improved solubility and reduced CYP3A4 inhibition compared to itraconazole.	pyridine	15-23	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	112-118
31913025-1	2020	Treatment of [Ir(PPh3)3Cl] with 2-[5-(pyridin-2-yl)-1H-pyrrol-2-yl]pyridine (Hdpp) in refluxing toluene affords an unexpected pyrrole-metalated iridium(III) hydride complex, [Ir(K2C,N-dpp)(H)(Cl)(PPh3)2] (1), via Cpyrrole-H activation, while the presence of the base KOtBu as the deprotonation reagent produces a pyridine-metalated iridium(III) hydride complex, [Ir(K3C,N,N-dpp)(H)(PPh3)2] (2), via Cpyridine-H activation.	pyridine	313-352	protein phosphatase 4 catalytic subunit	Homo sapiens	17-21
30175689-2	2020	The results showed that over 98% of pyridine (influent concentration &lt;=200 mg L-1) was degraded under intermittent micro-aerobic condition, while about 21% of pyridine was removed under anaerobic condition.	pyridine	36-44	immunoglobulin kappa variable 1-16	Homo sapiens	81-84
32085409-0	2020	How Different Substitution Positions of F, Cl Atoms in Benzene Ring of 5-Methylpyrimidine Pyridine Derivatives Affect the Inhibition Ability of EGFRL858R/T790M/C797S Inhibitors: A Molecular Dynamics Simulation Study.	pyridine	90-98	epidermal growth factor receptor	Homo sapiens	144-148
32121059-0	2020	Alpha-Synuclein Amyloid Aggregation Is Inhibited by Sulfated Aromatic Polymers and Pyridinium Polycation.	pyridine	83-93	synuclein alpha	Homo sapiens	0-15
32121059-5	2020	Conversely, pyridinium polycation, poly(N-ethylvinylpyridinium), switched the mechanism of alpha-synuclein aggregation from amyloidogenic to amorphous, which resulted in the formation of large amorphous aggregates that do not bind with thioflavin T.	pyridine	12-22	synuclein alpha	Homo sapiens	91-106
31910972-1	2020	A biomimetic assembly of per-O-methylated-cyclodextrin dimer with cobalt proto-porphyrin (CoIII-PPIX@Py2CD) was achieved via covalent linkage between CoIII of CoIII-PPIX and pyridine N of Py2CD (primarily synthesized by the acyl chlorination reaction of two beta-CDs monomers with 3,5-bis (bromomethyl) pyridine).	pyridine	174-182	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	90-95
31910972-1	2020	A biomimetic assembly of per-O-methylated-cyclodextrin dimer with cobalt proto-porphyrin (CoIII-PPIX@Py2CD) was achieved via covalent linkage between CoIII of CoIII-PPIX and pyridine N of Py2CD (primarily synthesized by the acyl chlorination reaction of two beta-CDs monomers with 3,5-bis (bromomethyl) pyridine).	pyridine	174-182	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	150-155
31910972-1	2020	A biomimetic assembly of per-O-methylated-cyclodextrin dimer with cobalt proto-porphyrin (CoIII-PPIX@Py2CD) was achieved via covalent linkage between CoIII of CoIII-PPIX and pyridine N of Py2CD (primarily synthesized by the acyl chlorination reaction of two beta-CDs monomers with 3,5-bis (bromomethyl) pyridine).	pyridine	174-182	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	150-155
31930239-7	2020	Variation of substituents at the pyridine ring results in the formation of [beta-{AgL}2Mo8O26]2- in the case of 2-NH2-py (8), 2-CH3-Py (9), 2,4,6-collidine (10) and 2,6-NH2-py (11).	pyridine	33-41	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	82-85
31913025-5	2020	The dpp-/dpp2- ligand shows rich coordination capability, of which pyridine- and pyrrole-cyclometalated coordination modes are first reported.	pyridine	67-75	dipeptidyl peptidase 7	Homo sapiens	9-13
31724854-1	2019	Nicotinamide N-methyltransferase (NNMT) catalyzes the methyl transfer from the cofactor S-adenosylmethionine to nicotinamide and other pyridine-containing compounds.	pyridine	135-143	nicotinamide N-methyltransferase	Homo sapiens	0-32
31801014-5	2019	The crucial role of pyridine in dictating the structural properties of such a cocrystal (Py-POR-COF) is discussed.	pyridine	20-28	cytochrome p450 oxidoreductase	Homo sapiens	92-95
31753515-5	2020	In this study, we illustrated the synthesis of new families of lipophilic pyridine and tetrahydropyridine derivatives designed as potential modulators of SK3 channel.	pyridine	74-82	potassium calcium-activated channel subfamily N member 3	Homo sapiens	154-157
31724854-1	2019	Nicotinamide N-methyltransferase (NNMT) catalyzes the methyl transfer from the cofactor S-adenosylmethionine to nicotinamide and other pyridine-containing compounds.	pyridine	135-143	nicotinamide N-methyltransferase	Homo sapiens	34-38
31513206-3	2019	Complex 2a immediately reacted with the liberated dihydrogen to yield mu-eta2-dihydrobipyridine (dhbpy) complex 4a via C-C bond formation between the two pyridyl groups, in which one of the pyridine rings underwent partial hydrogenation.	pyridine	87-95	DNA polymerase iota	Homo sapiens	73-77
31674149-1	2019	Coordination complexes of an olefinic molecule (PIP) containing pyridine and imidazopyridine moieties with Zn(II)/Ni(II) metal salts were shown to exhibit appreciable proton conductivity.	pyridine	64-72	prolactin induced protein	Homo sapiens	48-51
31675222-1	2019	We describe the template-free synthesis of the bis(pyridine-dienamine) proligand [4,5-(m-xylylenediamine)NH-C (CH)(9-butyl-octahydroacridine)]2 (2"), a variant of Burrows"s macrocyclic bis(pyridine-diimine) (bis-PDI) ligand [2,6-(m-xylylenediamine)N C(py)]2 (A), using octahydroacridine as the ligand backbone.	pyridine	51-69	peptidyl arginine deiminase 1	Homo sapiens	212-215
31585263-3	2019	Some new inhibitors of AChE combining pyridine, acylhydrazone and N-benzylpiperidine fragments were developed in this work.	pyridine	38-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	23-27
31675222-3	2019	The template-free synthesis of 2" enables facile access to a wide array of bis-PDI and bis(pyridine-dienamido) (bis-PDE) metal complexes.	pyridine	87-110	aldehyde dehydrogenase 7 family member A1	Homo sapiens	116-119
31589421-2	2019	A diverse array of unsubstituted N-heteroarenes including pyridine, pyrrole and pyrazine, traditionally challenging substrates for hydrogenation, were successfully hydrogenated using the organometallic precatalysts, (eta5-C5Me5)Rh(N-C)H (N-C = 2-phenylpyridinyl (ppy) or benzo[h]quinolinyl (bq)).	pyridine	58-66	Sp2 transcription factor	Homo sapiens	240-242
31621324-0	2019	Energy Decomposition Analysis for Interactions of Radicals: Theory and Implementation at the MP2 Level with Application to Hydration of Halogenated Benzene Cations and Complexes between CO2-  and Pyridine and Imidazole.	pyridine	196-204	tryptase pseudogene 1	Homo sapiens	93-96
31621324-5	2019	As a second application, relevant to the activation of CO2 in photoelectrocatalysis, complexes of CO2-  interacting with both pyridine and imidazole are analyzed with ALMO-MP2-EDA.	pyridine	126-134	tryptase pseudogene 1	Homo sapiens	172-175
31621324-5	2019	As a second application, relevant to the activation of CO2 in photoelectrocatalysis, complexes of CO2-  interacting with both pyridine and imidazole are analyzed with ALMO-MP2-EDA.	pyridine	126-134	ectodysplasin A	Homo sapiens	176-179
31473473-0	2019	Dual VEGFR-2/PIM-1 kinase inhibition towards surmounting the resistance to antiangiogenic agents via hybrid pyridine and thienopyridine-based scaffolds: Design, synthesis and biological evaluation.	pyridine	108-116	kinase insert domain receptor	Homo sapiens	5-12
31473473-0	2019	Dual VEGFR-2/PIM-1 kinase inhibition towards surmounting the resistance to antiangiogenic agents via hybrid pyridine and thienopyridine-based scaffolds: Design, synthesis and biological evaluation.	pyridine	108-116	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	13-18
31557043-1	2019	Aerobic Pd(AcO)2/pyridine-catalyzed oxidation of unprotected carbohydrate-based terminal alkenes was studied.	pyridine	17-25	aconitase 2	Homo sapiens	11-16
31588947-1	2019	An efficient and convenient synthesis of diversely substituted naphtho[1",2":4,5]imidazo[1,2-a]-pyridine derivatives from the cascade reactions of 2-arylimidazo[1,2-a]pyridines with a-diazo carbonyl compounds via Rh(iii)-catalyzed regioselective C(sp2)-H alkylation followed by intramolecular annulation is presented.	pyridine	147-176	Sp2 transcription factor	Homo sapiens	246-251
31350807-1	2019	Photodynamic behavior controlled by the synergy of electron transfer and charge transfer has been characterized in two regioisomeric pyridinium-bearing coordination polymers (Cd-Bip and Cd-Bpy) with the help of a smart charge-distribution-related isoreticular strategy.	pyridine	133-143	heat shock protein family A (Hsp70) member 5	Homo sapiens	178-181
31434476-10	2019	Codelivery of functional gene (pCEP4-p53) and drug (doxorubicin) was accomplished in vitro and in vivo with the chitosan-pyridine imine vector, (py)CS(CH2COOH), and the newly synthesized doxorubicin oxime ether, CS(Dox).	pyridine	144-148	tumor protein p53	Homo sapiens	37-40
31539015-4	2019	For a given FLP, the introduction of an electron donating -NMe2 group at the para position of the pyridine ring somewhat lowers the barrier and enhances the B-X (X = O, N, S) interaction.	pyridine	98-106	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	59-63
31618886-0	2019	Pyridine-Containing Macrocycles Display MMP-2/9 Inhibitory Activity and Distinct Effects on Migration and Invasion of 2D and 3D Breast Cancer Models.	pyridine	0-8	matrix metallopeptidase 2	Homo sapiens	40-47
31618886-2	2019	Herein, two pyridine-containing macrocyclic compounds, [15]pyN5 and [16]pyN5, were synthesized, chemically characterized and evaluated as potential MMP inhibitors for breast cancer therapy using 3D and 2D cellular models.	pyridine	12-20	matrix metallopeptidase 2	Homo sapiens	148-151
31618886-5	2019	Moreover, although no significant differences were observed in the invasion studies in the presence of all MMPs inhibitors, cell migration was significantly inhibited by both pyridine-containing macrocycles at concentrations above 5 muM in 2D cells (p < 0.05).	pyridine	175-183	matrix metallopeptidase 2	Homo sapiens	107-111
31462037-4	2019	Upon adding 2 equiv of NaEt3BH, hydride transfer to one chelate imine functionality was observed, resulting in the formation of (kappa4-N,N,N,N-PyEtIPCHMeNEtPy)Co. Single-crystal X-ray diffraction and density functional theory calculations revealed that this compound possesses a low-spin Co(II) ground state featuring antiferromagnetic coupling to a singly reduced imino(pyridine) moiety.	pyridine	372-380	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	289-295
30477412-4	2019	This work describes the computational search for new inhibitors using a hit optimization process of the previously reported AKT pan inhibitor, a 2,4,6-trisubstituted pyridine.	pyridine	166-174	AKT serine/threonine kinase 1	Homo sapiens	124-127
31095793-0	2019	Pyridine derivatives as anticancer lead compounds with Fatty Acid Synthase as the target: An in silico-guided in vitro study.	pyridine	0-8	fatty acid synthase	Homo sapiens	55-74
31496256-2	2019	Highly selective C-C bond cleavage of gamma-substituted tert-propargyl alcohols occurred, together with pyridine-directed ortho C(sp2)-H bond activation, affording a series of 2-arylindoles with yields up to 90%.	pyridine	104-112	Sp2 transcription factor	Homo sapiens	128-133
31616834-2	2019	Herein, we report the first examples of mononuclear cyclometallated iridium(III) complexes incorporating phosphonate ligands, namely, [Ir(ppy)2(HL1)] 0.5H2O (1), [Ir(ppy)2(HL2)] 0.5H2O (2), [Ir(dfppy)2(HL1)] (3), and [Ir(dfppy)2(HL2)] 3.5H2O (4) (ppy = 2-phenylpyridine, dfppy = 2-(2,4-difluorophenyl)pyridine, H2L1 = 2-pyridylphosphonic acid, H2L2 = 2-quinolinephosphonic acid).	pyridine	279-309	asialoglycoprotein receptor 1	Homo sapiens	144-147
31408327-1	2019	The treatment of pyridine- and pyrazole-ligated NiII sigma-aryl complexes with Selectfluor results in C(sp2)-F bond formation under mild conditions.	pyridine	17-25	Sp2 transcription factor	Homo sapiens	102-107
31220668-3	2019	We reported a series of potential BET inhibitors through incorporation of imidazole into pyridine scaffold.	pyridine	89-97	delta/notch like EGF repeat containing	Homo sapiens	34-37
30175693-0	2019	Probing the binding mechanism of substituted pyridine derivatives as effective and selective lysine-specific demethylase 1 inhibitors using 3D-QSAR, molecular docking and molecular dynamics simulations.	pyridine	45-53	lysine demethylase 1A	Homo sapiens	93-122
31128398-1	2019	The synthesis and characterization of two novel symmetric triazine-ring opening ligands CA-MP (pyridine derivative)/CA-BOPhen (1,10-phenanthroline derivative) functionalized SiO2-P (P = Polymer) adsorbents for separation of Pd(II) from HNO3 solutions are presented.	pyridine	95-103	cathelicidin antimicrobial peptide	Homo sapiens	88-93
31943952-4	2019	The TOF of the hydrosilylation of 4-chloroacetophenone with diphenylsilane was quite low (30 min-1 ), however the addition of a catalytic amount of Lewis base, especially pyridine, dramatically accelerated this hydrosilylation (980 min-1 ).	pyridine	171-179	CD59 molecule (CD59 blood group)	Homo sapiens	93-98
31943952-4	2019	The TOF of the hydrosilylation of 4-chloroacetophenone with diphenylsilane was quite low (30 min-1 ), however the addition of a catalytic amount of Lewis base, especially pyridine, dramatically accelerated this hydrosilylation (980 min-1 ).	pyridine	171-179	CD59 molecule (CD59 blood group)	Homo sapiens	232-237
31531195-0	2019	Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.	pyridine	15-23	VRK serine/threonine kinase 1	Homo sapiens	55-87
30175693-2	2019	In this work, we carried out a molecular modeling study on the substituted pyridine derivatives as LSD1 inhibitors using three-dimensional quantitative structure-activity relationship (3D-QSAR), molecular docking and molecular dynamics (MD) simulations.	pyridine	75-83	lysine demethylase 1A	Homo sapiens	99-103
31145622-2	2019	Building on from this discovery, and following structure-activity relationship investigations guided by computational modeling, a novel series of pyridine scaffold compounds were developed as irreversible CatC inhibitors, further culminated in identifying a highly potent and selective inhibitor 22, which displays good metabolic stability and oral bioavailability.	pyridine	146-154	cathepsin C	Homo sapiens	205-209
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	pyridine	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	pyridine	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-22
31020956-6	2019	Under optimum conditions (5% Cu doped ZnO, dose of 1.2 g L-1 for pyridine and 1.6 g L-1 for quinoline, pH = 11 and time = 5 h), the maximum pyridine and quinoline mineralization efficiencies were found to be 92.4% and 74.3%, respectively.	pyridine	65-73	immunoglobulin kappa variable 1-16	Homo sapiens	57-60
31020956-6	2019	Under optimum conditions (5% Cu doped ZnO, dose of 1.2 g L-1 for pyridine and 1.6 g L-1 for quinoline, pH = 11 and time = 5 h), the maximum pyridine and quinoline mineralization efficiencies were found to be 92.4% and 74.3%, respectively.	pyridine	140-148	immunoglobulin kappa variable 1-16	Homo sapiens	57-60
31020956-6	2019	Under optimum conditions (5% Cu doped ZnO, dose of 1.2 g L-1 for pyridine and 1.6 g L-1 for quinoline, pH = 11 and time = 5 h), the maximum pyridine and quinoline mineralization efficiencies were found to be 92.4% and 74.3%, respectively.	pyridine	140-148	immunoglobulin kappa variable 1-16	Homo sapiens	84-87
31120459-1	2019	Disclosed herein is a rhodium(iii)-catalyzed novel one-step back-to-back double rollover annulation on pyridine and pyrazine backbones leading to a structurally and optoelectronically diverse class of nicely decorated multi-ring-fused, extensively pi-conjugated, N-enriched PAH molecules by virtue of orchestrated quadruple C-H activation events.	pyridine	103-111	phenylalanine hydroxylase	Homo sapiens	274-277
31656687-1	2019	Alkylated pyridines are common in pharmaceuticals, and metal catalysis is frequently used to prepare this motif via Csp2-Csp3 coupling processes.	pyridine	10-19	regulator of calcineurin 2	Homo sapiens	116-120
31016975-6	2019	Kinetic studies revealed that pyridine binding slows down the formation of the tetrazido complex by blocking azide coordination to the CoIII imido.	pyridine	30-38	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	135-140
31231641-0	2019	Theoretical Approaches for Modeling the Effect of the Electrode Potential in the SERS Vibrational Wavenumbers of Pyridine Adsorbed on a Charged Silver Surface.	pyridine	113-121	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	81-85
31013090-1	2019	Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory domain, known as UCR2, that opens and closes over the catalytic site for cAMP hydrolysis.	pyridine	6-14	phosphodiesterase 4D	Homo sapiens	85-90
30978400-0	2019	Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.	pyridine	50-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	121-141
31139552-6	2019	These results allowed us to establish that pyridine substituent remarkably influences activation energy and reaction yield, as well as in acetylcholinesterase (AChE) activity.	pyridine	43-51	acetylcholinesterase (Cartwright blood group)	Homo sapiens	138-158
31139552-6	2019	These results allowed us to establish that pyridine substituent remarkably influences activation energy and reaction yield, as well as in acetylcholinesterase (AChE) activity.	pyridine	43-51	acetylcholinesterase (Cartwright blood group)	Homo sapiens	160-164
31002260-9	2019	The simultaneous application of two related pyridine derivatives is the efficient synthetic route for the multistep FeII SCO in the cyanido-bridged framework which is a promising step toward rational design of advanced spin transition molecular switches.	pyridine	44-52	spindlin 1	Homo sapiens	219-223
30919851-3	2019	The SERS activity of the nanotags was investigated with 2-mercaptopyridine (2-Mpy) as a Raman reporter, which could form pyridine/Ag+ coordination complexes to mediate the formation of silver shells.	pyridine	66-74	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	4-8
31459902-1	2019	The second-order Moller-Plesset perturbation theory (MP2) and density functional theory with dispersion function calculations have been applied to investigate the hydrogen-bonding interaction between azines and water.	pyridine	200-206	tryptase pseudogene 1	Homo sapiens	53-56
30843696-2	2019	Based on the scaffold of a known P2Y12 antagonist AZD1283, a series of novel bicyclic pyridine derivatives were designed and synthesized.	pyridine	86-94	purinergic receptor P2Y12	Rattus norvegicus	33-38
30933557-5	2019	These compounds, which include 4-chloropyridine and 4-chloronicotinamide, exploit the broad substrate scope of NNMT; methylation of the pyridine nitrogen enhances the electrophilicity of the C4 position, thereby promoting an aromatic nucleophilic substitution by C159, a noncatalytic cysteine.	pyridine	39-47	nicotinamide N-methyltransferase	Homo sapiens	111-115
30761702-2	2019	Upon addition of pyridine, both NiII centers became hexacoordinated by accepting two axial pyridines, which triggered a spin-state change of the NiII centers from diamagnetic (S=0) to paramagnetic (S=1).	pyridine	17-25	spindlin 1	Homo sapiens	120-124
31133770-5	2019	Overall, these studies demonstrate that proximal ligand substitution provides a promising strategy to tune the reactivity of myoglobin-based carbene and nitrene transfer catalysts and provide a first, proof-of-principle demonstration of the viability of pyridine-, thiophene-, and aniline-based unnatural amino acids for metalloprotein engineering.	pyridine	254-262	myoglobin	Homo sapiens	125-134
30862161-3	2019	Several of these pyridine-fused rigid polyheterocycles are shown to bind to Abeta and alpha-synuclein fibrils, which are associated with neurodegenerative diseases.	pyridine	17-25	amyloid beta precursor protein	Homo sapiens	76-81
30862161-3	2019	Several of these pyridine-fused rigid polyheterocycles are shown to bind to Abeta and alpha-synuclein fibrils, which are associated with neurodegenerative diseases.	pyridine	17-25	synuclein alpha	Homo sapiens	86-101
30789743-8	2019	The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential.	pyridine	257-265	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	41-45
30789743-8	2019	The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential.	pyridine	257-265	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	50-54
30789743-8	2019	The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential.	pyridine	257-265	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	50-54
30789743-8	2019	The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential.	pyridine	257-265	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	50-54
30789743-8	2019	The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential.	pyridine	257-265	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	50-54
29380674-0	2019	Identification of the hot spot residues for pyridine derivative inhibitor CCT251455 and ATP substrate binding on monopolar spindle 1 (MPS1) kinase by molecular dynamic simulation.	pyridine	44-52	TTK protein kinase	Homo sapiens	113-132
31015910-0	2019	Identification and biological evaluation of novel benzothiazole derivatives bearing a pyridine-semicarbazone moiety as apoptosis inducers via activation of procaspase-3 to caspase-3.	pyridine	86-94	caspase 3	Homo sapiens	156-168
31015910-0	2019	Identification and biological evaluation of novel benzothiazole derivatives bearing a pyridine-semicarbazone moiety as apoptosis inducers via activation of procaspase-3 to caspase-3.	pyridine	86-94	caspase 3	Homo sapiens	159-168
33833470-3	2019	Due to the efficient charge separation in the coordination process of Pt(PEt3)2(OTf)2 with pyridine and carboxylic acid and the directionality of metal-coordination bonds, these cages were prepared in high isolated yields (more than 90%).	pyridine	91-99	POU class 2 homeobox 2	Homo sapiens	70-85
29380674-0	2019	Identification of the hot spot residues for pyridine derivative inhibitor CCT251455 and ATP substrate binding on monopolar spindle 1 (MPS1) kinase by molecular dynamic simulation.	pyridine	44-52	TTK protein kinase	Homo sapiens	134-138
30800469-1	2019	The title mol-ecular salts, C16H16NO+ PF6 -, (I), and C21H21N2 + PF6 -, (II), are pyridine derivatives.	pyridine	82-90	sperm associated antigen 17	Homo sapiens	38-41
30800469-1	2019	The title mol-ecular salts, C16H16NO+ PF6 -, (I), and C21H21N2 + PF6 -, (II), are pyridine derivatives.	pyridine	82-90	sperm associated antigen 17	Homo sapiens	65-68
30679627-4	2019	Here, the human enzymes CBS, CSE and MST were expressed and purified from Escherichia coli, and thirty-one pyridine derivatives were synthesized and screened for their ability to bind and inhibit these enzymes.	pyridine	107-115	cystathionine beta-synthase	Homo sapiens	24-27
30679627-4	2019	Here, the human enzymes CBS, CSE and MST were expressed and purified from Escherichia coli, and thirty-one pyridine derivatives were synthesized and screened for their ability to bind and inhibit these enzymes.	pyridine	107-115	cystathionine gamma-lyase	Homo sapiens	29-32
30669688-0	2019	Dual Geometry Schemes in Tetrel Bonds: Complexes between TF4 (T = Si, Ge, Sn) and Pyridine Derivatives.	pyridine	82-90	MAX dimerization protein MLX	Homo sapiens	57-60
30503935-6	2019	Therefore, 1,2,3-triazole could serve as a promising DFG binding group for multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 bearing pyridine as hinge binding group.	pyridine	135-143	kinase insert domain receptor	Homo sapiens	102-109
30503935-6	2019	Therefore, 1,2,3-triazole could serve as a promising DFG binding group for multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 bearing pyridine as hinge binding group.	pyridine	135-143	TEK receptor tyrosine kinase	Homo sapiens	111-116
30503935-6	2019	Therefore, 1,2,3-triazole could serve as a promising DFG binding group for multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 bearing pyridine as hinge binding group.	pyridine	135-143	EPH receptor B4	Homo sapiens	121-126
30566349-6	2019	As proof of concept, the SN1/SN2 preferences for the reaction of tBu-triflate with pyridine (SN2 to SN1) and with piperidine (SN1 to SN2) were switched by both charged functional groups and point charges (i.e., electric fields) along the reaction axis, with a positive charge on the nucleophile side favoring SN1 and a negative charge favoring SN2 for these reactions.	pyridine	83-91	solute carrier family 38 member 3	Homo sapiens	25-28
30618250-7	2019	Pyridine interacts with (tmtaa)CoII to form a five-coordinate monopyridine complex in which the unpaired electron is in the d z2 orbital.	pyridine	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
30566349-6	2019	As proof of concept, the SN1/SN2 preferences for the reaction of tBu-triflate with pyridine (SN2 to SN1) and with piperidine (SN1 to SN2) were switched by both charged functional groups and point charges (i.e., electric fields) along the reaction axis, with a positive charge on the nucleophile side favoring SN1 and a negative charge favoring SN2 for these reactions.	pyridine	83-91	solute carrier family 38 member 5	Homo sapiens	29-32
30566349-6	2019	As proof of concept, the SN1/SN2 preferences for the reaction of tBu-triflate with pyridine (SN2 to SN1) and with piperidine (SN1 to SN2) were switched by both charged functional groups and point charges (i.e., electric fields) along the reaction axis, with a positive charge on the nucleophile side favoring SN1 and a negative charge favoring SN2 for these reactions.	pyridine	83-91	solute carrier family 38 member 5	Homo sapiens	93-96
30566349-6	2019	As proof of concept, the SN1/SN2 preferences for the reaction of tBu-triflate with pyridine (SN2 to SN1) and with piperidine (SN1 to SN2) were switched by both charged functional groups and point charges (i.e., electric fields) along the reaction axis, with a positive charge on the nucleophile side favoring SN1 and a negative charge favoring SN2 for these reactions.	pyridine	83-91	solute carrier family 38 member 3	Homo sapiens	100-103
30566349-6	2019	As proof of concept, the SN1/SN2 preferences for the reaction of tBu-triflate with pyridine (SN2 to SN1) and with piperidine (SN1 to SN2) were switched by both charged functional groups and point charges (i.e., electric fields) along the reaction axis, with a positive charge on the nucleophile side favoring SN1 and a negative charge favoring SN2 for these reactions.	pyridine	83-91	solute carrier family 38 member 3	Homo sapiens	100-103
30566349-6	2019	As proof of concept, the SN1/SN2 preferences for the reaction of tBu-triflate with pyridine (SN2 to SN1) and with piperidine (SN1 to SN2) were switched by both charged functional groups and point charges (i.e., electric fields) along the reaction axis, with a positive charge on the nucleophile side favoring SN1 and a negative charge favoring SN2 for these reactions.	pyridine	83-91	solute carrier family 38 member 5	Homo sapiens	93-96
30566349-6	2019	As proof of concept, the SN1/SN2 preferences for the reaction of tBu-triflate with pyridine (SN2 to SN1) and with piperidine (SN1 to SN2) were switched by both charged functional groups and point charges (i.e., electric fields) along the reaction axis, with a positive charge on the nucleophile side favoring SN1 and a negative charge favoring SN2 for these reactions.	pyridine	83-91	solute carrier family 38 member 3	Homo sapiens	100-103
30566349-6	2019	As proof of concept, the SN1/SN2 preferences for the reaction of tBu-triflate with pyridine (SN2 to SN1) and with piperidine (SN1 to SN2) were switched by both charged functional groups and point charges (i.e., electric fields) along the reaction axis, with a positive charge on the nucleophile side favoring SN1 and a negative charge favoring SN2 for these reactions.	pyridine	83-91	solute carrier family 38 member 5	Homo sapiens	93-96
30576125-8	2019	Our studies revealed that the pyridosteroid 3-hydroxy-5-en-2",3"-dicarbethoxy-androst[17,16- b]pyridine, bearing pyridine-2,3-dicarbethoxy pharmacophore, facilitated initiation of caspase-8 and activates downstream effectors caspase-6 and caspase-7 and thereby triggering apoptosis of PC-3 cancer cells.	pyridine	95-103	caspase 8	Mus musculus	180-189
30576125-8	2019	Our studies revealed that the pyridosteroid 3-hydroxy-5-en-2",3"-dicarbethoxy-androst[17,16- b]pyridine, bearing pyridine-2,3-dicarbethoxy pharmacophore, facilitated initiation of caspase-8 and activates downstream effectors caspase-6 and caspase-7 and thereby triggering apoptosis of PC-3 cancer cells.	pyridine	95-103	caspase 6	Mus musculus	225-234
30576125-8	2019	Our studies revealed that the pyridosteroid 3-hydroxy-5-en-2",3"-dicarbethoxy-androst[17,16- b]pyridine, bearing pyridine-2,3-dicarbethoxy pharmacophore, facilitated initiation of caspase-8 and activates downstream effectors caspase-6 and caspase-7 and thereby triggering apoptosis of PC-3 cancer cells.	pyridine	95-103	caspase 7	Mus musculus	239-248
30655950-8	2019	We found a dq analogue (22) that contains a methyl group at the C-5 position and a substituted pyridine at the C-6 position that exhibits &gt;10-fold selectivity for PARP10 over a large subset of other PARP family members.	pyridine	95-103	poly(ADP-ribose) polymerase family member 10	Homo sapiens	166-172
30426629-4	2019	Another symmetric compound, which bears a pyridine at each end, binds to ICF2 CF2 I through N   I halogen bonds to form two-component supramolecular P and M helices, with one turn consisting of four (2+2) molecules.	pyridine	42-50	zinc finger and BTB domain containing 24	Homo sapiens	73-77
31779878-6	2019	Certain RASER experiments involving the protons of 15N pyridine or 3-picoline molecules pumped with p-H2 via SABRE (Signal Amplification By Reversible Exchange) show either a single RASER oscillation in the time domain, giant RASER pulses or a complex RASER beat pattern.	pyridine	55-63	polyhomeotic homolog 2	Homo sapiens	100-104
29758567-7	2018	The effect of the heteroaromatic substituent on MAO-B inhibition activity, in decreasing order was found to be: cyclohexyl, phenyl&gt;thiophene&gt;pyridine, furane, pyrrole, cyclopentyl.	pyridine	147-155	monoamine oxidase B	Homo sapiens	48-53
29199489-3	2018	In this paper, we report the structural characterization of the adduct that a triphenylpyridinium derivative forms with hCA II, showing that the substitution of the pyridinium ring plays a key role in determining the conformation of the inhibitor in the active site and consequently the binding affinity to the enzyme.	pyridine	87-97	carbonic anhydrase 2	Homo sapiens	120-126
30165066-3	2018	Both drugs form 1:1 hydrated (H2O: 13%-14% w/w) host-guest complexes, with sCX[8] binding around the pyridine ring of isoniazid, and around the piperazine and cyclopropane rings of CIP.	pyridine	101-109	scleraxis bHLH transcription factor	Homo sapiens	75-78
30562018-1	2019	A base-mediated protocol that allows for the site-selective sp2 C-H silylation of azines is described.	pyridine	82-88	Sp2 transcription factor	Homo sapiens	60-63
30621119-2	2019	o-Carborane was introduced to the C4 position of the pyridine rings of 2-phenylpyridine and 2-(benzo[b]thiophen-2-yl)pyridine (CB1 and CB2, respectively), and the compounds were subsequently borylated to obtain the corresponding CN-chelated compounds CB1B and CB2B.	pyridine	53-61	cannabinoid receptor 2	Homo sapiens	135-138
30836926-9	2019	Both the pyrimidine- and pyridine-based probes exhibited muM inhibitory activity against HDAC8.	pyridine	25-33	latexin	Homo sapiens	57-60
30836926-9	2019	Both the pyrimidine- and pyridine-based probes exhibited muM inhibitory activity against HDAC8.	pyridine	25-33	histone deacetylase 8	Homo sapiens	89-94
30124151-0	2019	Design, Synthesis of New Pyridine and Pyrimidine Sugar Compounds as Antagonists Targeting the ERalpha via Structure-Based Virtual Screening.	pyridine	25-33	estrogen receptor 1	Homo sapiens	94-101
30403230-5	2018	The pyridinium lead tribromide and pyridinium lead triiodide absorption peaks derived from the experimental DRS are located at ~3.1 eV and ~2.4 eV, respectively.	pyridine	4-14	sushi repeat containing protein X-linked	Homo sapiens	108-111
30403230-5	2018	The pyridinium lead tribromide and pyridinium lead triiodide absorption peaks derived from the experimental DRS are located at ~3.1 eV and ~2.4 eV, respectively.	pyridine	35-45	sushi repeat containing protein X-linked	Homo sapiens	108-111
30655950-8	2019	We found a dq analogue (22) that contains a methyl group at the C-5 position and a substituted pyridine at the C-6 position that exhibits &gt;10-fold selectivity for PARP10 over a large subset of other PARP family members.	pyridine	95-103	poly(ADP-ribose) polymerase 1	Homo sapiens	166-170
30318539-4	2018	Furthermore, magnesium hydride-inherent reactivity was proven for [(thf)4Mg{(mu2-H)(AlMe3)}2] by the selective reduction of pyridine to 1,4-dihydropyridide (1,4-DHP) at ambient temperature and the hydromagnesiation of 1-hexene in the absence of any transition metal catalyst (low conversion).	pyridine	124-132	dihydropyrimidinase	Homo sapiens	161-164
30290988-0	2018	Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk.	pyridine	31-39	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	115-118
30056373-2	2018	Due to the key role of dynamic membrane in biomass retention, NH4+ released from pyridine biodegradation could be effectively nitrified to NO3- in oxic zone, which was then recirculated into the anoxic zone to serve as electron acceptor for pyridine biodegradation.	pyridine	81-89	NBL1, DAN family BMP antagonist	Homo sapiens	139-142
30056373-2	2018	Due to the key role of dynamic membrane in biomass retention, NH4+ released from pyridine biodegradation could be effectively nitrified to NO3- in oxic zone, which was then recirculated into the anoxic zone to serve as electron acceptor for pyridine biodegradation.	pyridine	241-249	NBL1, DAN family BMP antagonist	Homo sapiens	139-142
30056373-3	2018	Acetate dosage adversely affected pyridine biodegradation, due to the competitive effect of acetate towards NO3-.	pyridine	34-42	NBL1, DAN family BMP antagonist	Homo sapiens	108-111
30056373-4	2018	Increase of recirculation ratio positively affected pyridine biodegradation, due to high availability of NO3- at high recirculation ratio.	pyridine	52-60	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
30064079-1	2018	A series of pyridine and thieno[2,3-b]pyridine derivatives have been designed and synthesized as anticancer PIM-1 kinase inhibitors.	pyridine	12-20	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	108-113
30076638-2	2018	The intramolecular S   N interaction ensures that the thiophene and pyridine rings of ligands 1 and 2 are in coplanar and syn-locked structures.	pyridine	68-76	synemin	Homo sapiens	122-125
30349486-1	2018	Background: Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes N-methylation of pyridine-containing compounds.	pyridine	97-105	nicotinamide N-methyltransferase	Homo sapiens	12-44
30349486-1	2018	Background: Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes N-methylation of pyridine-containing compounds.	pyridine	97-105	nicotinamide N-methyltransferase	Homo sapiens	46-50
30064079-0	2018	Design, synthesis and docking study of pyridine and thieno[2,3-b] pyridine derivatives as anticancer PIM-1 kinase inhibitors.	pyridine	39-47	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	101-106
30106306-4	2018	The reaction was found to begin with the C(sp2)-H oxidative addition of the pyridine ligand to give the Ir(III) hydride intermediate, from which the isomerization further takes place via the insertion/elimination pathway.	pyridine	76-84	Sp2 transcription factor	Homo sapiens	41-46
29877036-4	2018	The results demonstrate that the introductions of thiazole and pyridine rings into 2TZ as well as the change in the orientation of inhibitors lead to the increase in the polar interactions of 2U0, 2U1, 2U5, 2U6, and 2U7 with MDM2 relative to 2TZ.	pyridine	63-71	MDM2 proto-oncogene	Homo sapiens	225-229
30325216-2	2018	In the present study the antiproliferative activity of 4-benzyl-5-phenyl-3,4-dihydropyrimidine-2(1H)-thione (1) and its pyridine bioisoster (2) were evaluated and compared with monastrol (MON), the first known cell-permeable small molecule which disrupts bipolar spindle formation by inhibiting Eg5-kinesin activity.	pyridine	120-128	kinesin family member 11	Homo sapiens	295-298
30148963-1	2018	Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues.	pyridine	130-138	nicotinamide N-methyltransferase	Homo sapiens	0-32
30148963-1	2018	Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues.	pyridine	130-138	nicotinamide N-methyltransferase	Homo sapiens	34-38
30009517-3	2018	Time-resolved Co K-edge X-ray absorption spectroscopy in the microsecond time range indicates that, for the [CoII (aPPy)] catalyst (aPPy=di([2,2"-bipyridin]-6-yl)(pyridin-2-yl)methanol), the pendant pyridine dissociates from the cobalt in the intermediate CoI state.	pyridine	199-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
30009517-3	2018	Time-resolved Co K-edge X-ray absorption spectroscopy in the microsecond time range indicates that, for the [CoII (aPPy)] catalyst (aPPy=di([2,2"-bipyridin]-6-yl)(pyridin-2-yl)methanol), the pendant pyridine dissociates from the cobalt in the intermediate CoI state.	pyridine	199-207	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	109-112
29995408-4	2018	Isosteric pyridine replacement and appendage of all available positions around the pyridine ring with a methyl group was performed to identify a modification that would increase CYP2A6 inhibition potency, which led to 4g (IC50 = 0.055 mM) as a primary analogue.	pyridine	10-18	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	178-184
30103189-0	2018	Pyridine bioisosteres of potent GluN2B subunit containing NMDA receptor antagonists with benzo[7]annulene scaffold.	pyridine	0-8	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	32-38
30103189-7	2018	The &gt;100-fold reduced GluN2B affinity of pyridines 11b and 11c compared to the GluN2B affinity of the corresponding chloro- and nitrobenzene derivatives 3d and 3e indicates that the pyridine ring is not tolerated as bioisosteric replacement of the chloro- or nitrobenzene ring in this type of compounds.	pyridine	44-52	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	25-31
30026114-1	2018	Two tetradentated pyridine-based manganese complexes (Cpd2 and Cpd3) were previously reported to inhibit efficiently the growth of Trypanosoma cruzi in vitro and in vivo.	pyridine	18-26	spinocerebellar ataxia, autosomal recessive 2	Homo sapiens	63-67
29862388-1	2018	A new luminescent mesoporous metal-organic framework (PCN-604) was successfully synthesized from trimetric clusters, Al3(O)(CH3COO)6, and pyridine-based tritopic linkers, 4,4",4""-(pyridine-2,4,6-triyl)tribenzoate (PTB), via a solvothermal reaction.	pyridine	138-146	pericentrin	Homo sapiens	54-57
29995408-4	2018	Isosteric pyridine replacement and appendage of all available positions around the pyridine ring with a methyl group was performed to identify a modification that would increase CYP2A6 inhibition potency, which led to 4g (IC50 = 0.055 mM) as a primary analogue.	pyridine	83-91	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	178-184
30960837-5	2018	PIL-IL composites membranes have also been prepared using the same PIL and different percentages of pyridinium based IL where it was shown that the membrane with the highest IL weight percentage (45 wt %) showed the highest CO2 permeability (11.8 Barrer) and a high CO2/CH4 ideal selectivity of 35 at room temperature.	pyridine	100-110	serpin family A member 2 (gene/pseudogene)	Homo sapiens	0-3
29784337-5	2018	In contrast to BQA-1, BQA-2 whose acrylic ester moiety is further modified with pyridine group, displays a turn-on fluorescence response to Cys with detection limit of 0.98 muM.	pyridine	80-88	latexin	Homo sapiens	173-176
29504638-2	2018	The best computational scheme for heterocyclic azines at the DFT level was found to be KT3/pcS-3//pc-2 (IEF-PCM).	pyridine	47-53	chromobox 4	Homo sapiens	98-102
30031655-3	2018	After acetylation of alcohol with Ac2O in pyridine, epoxidation reaction of formed monoacetates with m-CPBA, then chromatographed and followed by hydrolysis of the acetate groups with NH3 in CH3OH resulted in the formation of epoxy alcohol isomers respectively.	pyridine	42-50	adenylate cyclase 2	Homo sapiens	34-37
29878770-2	2018	Previous studies have reported a number of CYP11B2 inhibitors, most of which have an imidazole or pyridine ring to coordinate the heme-iron motif of CYP11B2; however, highly selective inhibitors of human CYP11B2 are still needed.	pyridine	98-106	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	43-50
29953212-2	2018	The paramagnetic 15-electron Co(II) complexes of the type [Co{kappa2 N,N"-5-R-NC4H2-2-C(H) N(2,6-iPr2-C6H3)}(Py)Cl] (3a-e; Py = pyridine) were prepared by salt metathesis of CoCl2(Py)4 with the respective potassium salts 2a-e in moderate to good yields.	pyridine	109-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
29953212-2	2018	The paramagnetic 15-electron Co(II) complexes of the type [Co{kappa2 N,N"-5-R-NC4H2-2-C(H) N(2,6-iPr2-C6H3)}(Py)Cl] (3a-e; Py = pyridine) were prepared by salt metathesis of CoCl2(Py)4 with the respective potassium salts 2a-e in moderate to good yields.	pyridine	128-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
29878770-2	2018	Previous studies have reported a number of CYP11B2 inhibitors, most of which have an imidazole or pyridine ring to coordinate the heme-iron motif of CYP11B2; however, highly selective inhibitors of human CYP11B2 are still needed.	pyridine	98-106	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	149-156
29878770-2	2018	Previous studies have reported a number of CYP11B2 inhibitors, most of which have an imidazole or pyridine ring to coordinate the heme-iron motif of CYP11B2; however, highly selective inhibitors of human CYP11B2 are still needed.	pyridine	98-106	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	149-156
29792688-3	2018	The X-type PAlP-Rh complexes catalyze C2-selective monoalkylation of pyridine with alkenes.	pyridine	69-77	alkaline phosphatase, placental	Homo sapiens	11-15
28592192-8	2018	Pyridine degradation in B1, B2 and B3 follows the Stover-Kincannon model with a maximum substrate removal rate of 111.1, 333.3 and 23.81 g/L day, respectively.	pyridine	0-8	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	24-37
29663544-2	2018	The introduction of an electron-donating substituent in one of the benzene rings of the GSA increased the decomposition temperature by 12 K, which is due to the stronger cation-pi interactions between the benzene ring and positively charged pyridinium rings and tighter molecular meshing between the GSAs in the nanocube.	pyridine	241-251	aldehyde dehydrogenase 18 family member A1	Homo sapiens	300-304
31458846-6	2018	The atomic charge on the pyridine nitrogen atom [rho(Npy)] was extracted from the natural orbital population analysis.	pyridine	25-33	neuropeptide Y	Homo sapiens	53-56
29615437-5	2018	Human AO substrates identified contained unsubstituted diazanaphthalene moieties (A77-01, INCB 28060, ML-347, LDN-193189, and SB-525334), 4-aminoquinazoline cores (lapatinib, lapatinib M1, and CL-387785), and terminal pyridine and pyrimidine groups (imatinib, bafetinib, and AMG 900).	pyridine	218-226	aldehyde oxidase 1	Homo sapiens	6-8
29120536-1	2018	This paper presents synthesis and structure-activity relationship of pyridine derivatives as inhibitors of mutant isocitrate dehydrogenase 2 (IDH2).	pyridine	69-77	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	142-146
29652496-7	2018	These adducts were synthesized by treating in situ-generated metallacyclobutane Ru-2 with pyridine or o-dianiline, and were isolated by precipitating at low temperature (-116 or -78  C, respectively).	pyridine	90-98	doublecortin domain containing 2	Homo sapiens	80-84
29735900-2	2018	For the recovery of inhibited AChE, antidotes from the group of pyridinium or bispyridinium aldoxime reactivators (pralidoxime, obidoxime, HI-6) are used in combination with anticholinergics and anticonvulsives.	pyridine	64-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-34
29573580-0	2018	Boosting ORR Catalytic Activity by Integrating Pyridine-N Dopants, a High Degree of Graphitization, and Hierarchical Pores into a MOF-Derived N-Doped Carbon in a Tandem Synthesis.	pyridine	47-55	lysine acetyltransferase 8	Homo sapiens	130-133
30108986-3	2018	Pyridine fusion to position 3,4 of the A-ring may dramatically enhance affinity of 17alpha-picolyl compounds for CYP17 while conferring selective antiproliferative activity against PC-3 cells.	pyridine	0-8	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	113-118
29143360-0	2018	Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation.	pyridine	20-28	H3 histone pseudogene 16	Homo sapiens	93-96
29537264-1	2018	The ground and excited state photophysical properties of a series of fac-[Re(L)(CO)3(alpha-diimine)] n+ complexes, where L = Br-, Cl-, 4-dimethylaminopyridine (dmap) and pyridine (py) have been extensively studied utilizing numerous electronic and vibrational spectroscopic techniques in conjunction with a suite of quantum chemical methods.	pyridine	150-158	FA complementation group C	Homo sapiens	69-72
32625865-0	2018	Scientific opinion on flavouring group evaluation 77, revision 3 (FGE.77Rev3): consideration of pyridine, pyrrole and quinoline derivatives evaluated by JECFA (63rd meeting) structurally related to pyridine, pyrrole, indole and quinoline derivatives evaluated by EFSA in FGE.24Rev2.	pyridine	198-206	REV3 like, DNA directed polymerase zeta catalytic subunit	Homo sapiens	72-76
29579393-3	2018	We compare experimental redshifts and equilibrium constants, obtained by combining experiments and theory, for these complexes to the corresponding complexes with pyridine (sp2-hybridized N) and trimethylamine (sp3-hybridized N).	pyridine	163-171	Sp2 transcription factor	Homo sapiens	173-176
29569919-3	2018	Here we show that pyridine also reacts under compression to form a well-ordered sp3 product: C5NH5 carbon nitride nanothreads.	pyridine	18-26	Sp3 transcription factor	Homo sapiens	80-83
29537264-1	2018	The ground and excited state photophysical properties of a series of fac-[Re(L)(CO)3(alpha-diimine)] n+ complexes, where L = Br-, Cl-, 4-dimethylaminopyridine (dmap) and pyridine (py) have been extensively studied utilizing numerous electronic and vibrational spectroscopic techniques in conjunction with a suite of quantum chemical methods.	pyridine	150-152	FA complementation group C	Homo sapiens	69-72
29420365-1	2018	Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes the N-methylation of nicotinamide and pyridine compounds, participating in xenobiotic and drug metabolism.	pyridine	106-114	nicotinamide N-methyltransferase	Homo sapiens	0-32
29620022-2	2018	The 1:1 adduct of pyridine and urea, C5H5N CH4N2O, crystallizes in the P21/c space group with Z = 4.	pyridine	18-26	H3 histone pseudogene 16	Homo sapiens	71-76
29620022-4	2018	The 1:1 adduct of pyridine and thiourea, C5H5N CH4N2S, crystallizes in the P21/n space group, with Z = 32 (Z" = 8).	pyridine	18-26	H3 histone pseudogene 16	Homo sapiens	75-78
29420365-1	2018	Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes the N-methylation of nicotinamide and pyridine compounds, participating in xenobiotic and drug metabolism.	pyridine	106-114	nicotinamide N-methyltransferase	Homo sapiens	34-38
29175739-1	2018	Herein, reduced graphene oxide supported porous PtAg alloy nanoflowers (PtAg NFs/rGO) were synthesized by a simple one-pot aqueous method using pyridinium-based dicationic ionic liquid (1,4-bis(pyridinium)butane dibromide, Bpb-2Br) as the new structure-director and stabilizing agent.	pyridine	144-154	rhomboid domain containing 3	Homo sapiens	48-52
29485857-8	2018	Furthermore, the presence of a water molecule interacting with the PMPC phosphonate and pyridine N-C2 pi-bond, as well as the nucleophilic hydroxide, suggests that the PMPC binds to the MBL active site as its hydrate.	pyridine	88-96	mannose-binding lectin family member 3, pseudogene	Homo sapiens	186-189
29175739-1	2018	Herein, reduced graphene oxide supported porous PtAg alloy nanoflowers (PtAg NFs/rGO) were synthesized by a simple one-pot aqueous method using pyridinium-based dicationic ionic liquid (1,4-bis(pyridinium)butane dibromide, Bpb-2Br) as the new structure-director and stabilizing agent.	pyridine	144-154	rhomboid domain containing 3	Homo sapiens	72-76
29320176-1	2018	Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of pyridine-containing compounds using the cofactor S-5"-adenosyl-l-methionine (SAM) as the methyl group donor.	pyridine	71-79	nicotinamide N-methyltransferase	Homo sapiens	0-32
29431796-2	2018	After BDP reacted with superoxide, the initial diphenyl-phosphinyl groups of BDP were cleaved, resulting in the production of the pyridinium modified fluorophore (BD) with near-infrared emission.	pyridine	130-140	AT-rich interaction domain 3B	Homo sapiens	6-9
29431796-2	2018	After BDP reacted with superoxide, the initial diphenyl-phosphinyl groups of BDP were cleaved, resulting in the production of the pyridinium modified fluorophore (BD) with near-infrared emission.	pyridine	130-140	AT-rich interaction domain 3B	Homo sapiens	77-80
29487300-4	2018	Through a rational design approach, novel FLT3 inhibitors were synthesized employing a pyridine/pyrimidine warhead.	pyridine	87-95	fms related receptor tyrosine kinase 3	Homo sapiens	42-46
29320176-1	2018	Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of pyridine-containing compounds using the cofactor S-5"-adenosyl-l-methionine (SAM) as the methyl group donor.	pyridine	71-79	nicotinamide N-methyltransferase	Homo sapiens	34-38
29353721-5	2018	Compound 23 bearing pyrimidine core functionalized with catechol, pyridine and trifluoromethyl groups can effectively inhibit the PDE4B with IC50 value in nanomolar range (IC50 = 15 +- 0.4 nM).	pyridine	66-74	phosphodiesterase 4B, cAMP specific	Mus musculus	130-135
28745236-0	2018	Synthesis of Pyridine and Spiropyridine Derivatives Derived from 2-aminoprop- 1-ene-1,1,3-tricarbonitrile Together with their c-Met Kinase and Antiproliferative Evaluations.	pyridine	13-21	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	126-131
29289880-0	2018	Design, synthesis and biological evaluation of novel pyridine-thiazolidinone derivatives as anticancer agents: Targeting human carbonic anhydrase IX.	pyridine	53-61	carbonic anhydrase 9	Homo sapiens	127-148
29253950-1	2018	The preparation, characterisation and application of two pyridine-modified chitosan derivatives (C1 and C2) containing Cu(OAc)2 adsorbed as catalysts for the conversion of benzaldehyde into 2-nitro-1-phenylethanol are described.	pyridine	57-65	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	97-127
28150530-8	2018	The binding affinities of these seven compounds on AKT1 and AKT3 isoforms were mainly determined by hydrophobic contributions between the aromatic portion at position 4 of the pyridine ring with residues Phe236/234, Phe237/235, Phe438/435, and Phe442/439 in the ATP binding pocket.	pyridine	176-184	AKT serine/threonine kinase 1	Homo sapiens	51-55
28150530-8	2018	The binding affinities of these seven compounds on AKT1 and AKT3 isoforms were mainly determined by hydrophobic contributions between the aromatic portion at position 4 of the pyridine ring with residues Phe236/234, Phe237/235, Phe438/435, and Phe442/439 in the ATP binding pocket.	pyridine	176-184	AKT serine/threonine kinase 3	Homo sapiens	60-64
29303259-3	2018	Hydride reduction of the activated pyridine in [(Py)2 Bpin]OTf 4 by NHP-H 5 affords the 1,4-hydroboration product selectively.	pyridine	35-43	POU class 5 homeobox 1	Homo sapiens	59-64
29233614-5	2018	The strongest and most selective P-gp inhibition was found for the epimeric azines 5 and 6, bearing a para-methylbenzylidene moiety.	pyridine	76-82	phosphoglycolate phosphatase	Homo sapiens	33-37
29316677-5	2018	Compounds 2k, 2l and 2n, with N-methylpyrrole, furan and pyridine moieties instead of the phenyl ring, were the most powerful and specific inhibitors of MAO-A, with IC50 values of 6.12 muM, 10.64 muM and 9.52 muM, respectively.	pyridine	57-65	monoamine oxidase A	Mus musculus	153-158
29128496-12	2018	Thus, we have concluded that the binding constant of pyridine to Ni(II) porphyrinoid increases by the following order: Por&lt;Chl&lt;Iso&lt;Pyr.	pyridine	53-61	cytochrome p450 oxidoreductase	Homo sapiens	119-122
29131470-0	2018	Synthesis of some novel pyridine compounds containing bis-1,2,4-triazole/thiosemicarbazide moiety and investigation of their antioxidant properties, carbonic anhydrase, and acetylcholinesterase enzymes inhibition profiles.	pyridine	24-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	149-193
29257679-1	2018	Photoinduced ligand dissociation of pyridine occurs much more readily in [Ru(tpy)(Me2bpy)(py)]2+ than in [Ru(tpy)(bpy)(py)]2+ (tpy = 2,2":6",2""-terpyridine; bpy = 2,2"-bipyridine, Me2bpy = 6,6"-dimethyl-2,2"-bipyridine; py = pyridine).	pyridine	36-44	malic enzyme 2	Homo sapiens	82-85
29257679-1	2018	Photoinduced ligand dissociation of pyridine occurs much more readily in [Ru(tpy)(Me2bpy)(py)]2+ than in [Ru(tpy)(bpy)(py)]2+ (tpy = 2,2":6",2""-terpyridine; bpy = 2,2"-bipyridine, Me2bpy = 6,6"-dimethyl-2,2"-bipyridine; py = pyridine).	pyridine	36-38	malic enzyme 2	Homo sapiens	82-85
29257679-1	2018	Photoinduced ligand dissociation of pyridine occurs much more readily in [Ru(tpy)(Me2bpy)(py)]2+ than in [Ru(tpy)(bpy)(py)]2+ (tpy = 2,2":6",2""-terpyridine; bpy = 2,2"-bipyridine, Me2bpy = 6,6"-dimethyl-2,2"-bipyridine; py = pyridine).	pyridine	148-156	malic enzyme 2	Homo sapiens	82-85
29172085-5	2018	Compared with the lead compound 1, docking and MD refinement of the Hsp90alpha-41 complex revealed a favorable H-bonding interaction between the side-chain of Tyr139 and the pyridine moiety of 41, which is the first time to be used for resorcinol-based Hsp90 inhibitors.	pyridine	174-182	heat shock protein 90 alpha family class A member 1	Homo sapiens	68-78
29172085-5	2018	Compared with the lead compound 1, docking and MD refinement of the Hsp90alpha-41 complex revealed a favorable H-bonding interaction between the side-chain of Tyr139 and the pyridine moiety of 41, which is the first time to be used for resorcinol-based Hsp90 inhibitors.	pyridine	174-182	heat shock protein 90 alpha family class A member 1	Homo sapiens	68-73
29210572-4	2017	X-ray absorption spectroscopic studies showed that the Co K rising edge of Co[TPC](PPh3) (TPC = triphenylcorrole) is red-shifted by ~1.8 eV relative to the bona fide Co(III) complexes Co[TPC](py)2 and Co[TPP](py)Cl (TPP = tetraphenylporphyrin, py = pyridine), consistent with a partial CoII-corrole 2- description for Co[TPC](PPh3).	pyridine	192-194	protein phosphatase 4 catalytic subunit	Homo sapiens	83-87
29281977-2	2017	To identify the most effective anti-neuroinflammatory agent, we designed and synthesized a family of 13 new azine derivatives and investigated their anti-neuroinflammatory activities in LPS-activated BV-2 microglial cells.	pyridine	108-113	toll-like receptor 4	Mus musculus	186-189
29210572-4	2017	X-ray absorption spectroscopic studies showed that the Co K rising edge of Co[TPC](PPh3) (TPC = triphenylcorrole) is red-shifted by ~1.8 eV relative to the bona fide Co(III) complexes Co[TPC](py)2 and Co[TPP](py)Cl (TPP = tetraphenylporphyrin, py = pyridine), consistent with a partial CoII-corrole 2- description for Co[TPC](PPh3).	pyridine	249-257	protein phosphatase 4 catalytic subunit	Homo sapiens	83-87
27781494-0	2017	Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency.	pyridine	68-73	free fatty acid receptor 1	Homo sapiens	12-17
28972144-0	2017	Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing.	pyridine	14-22	Gag-Pol	Human immunodeficiency virus 1	94-101
29079014-2	2017	In particular, the introduction of a NH group between the pyridine ring and the phenyl nucleus generated the amino-phenyl-urea derivative SN15b that behaved as a positive allosteric modulator (PAM), increasing the CB1R binding affinity of the orthosteric ligand CP55,940.	pyridine	58-66	cannabinoid receptor 1	Homo sapiens	214-218
29184932-2	2017	Compounds L6-8 were prepared, for comparison, to further explore the mechanism of the binding of L1-5 with RNA, which revealed that the synergistic effect of the amino group and the pyridinium cation played a significant role in distinct cell imaging.	pyridine	182-192	immunoglobulin kappa variable 1D-16	Homo sapiens	97-101
29031067-0	2017	New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation.	pyridine	4-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-62
29031067-1	2017	A new series of pyridine derivatives with carbamic or amidic function has been designed and synthesized to act as cholinesterase inhibitors.	pyridine	16-24	butyrylcholinesterase	Homo sapiens	114-128
28940713-3	2017	Switching the solvent to pyridine induces a remarkable change in the dehydrocoupling product ratio, with (NMe2 )2 BH favoured over [NMe2 BH2 ]2 (e.g., 94 %:2 % for 1tLi).	pyridine	25-33	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	106-110
29136075-0	2017	Coordinatively- and electronically-unsaturated square planar cobalt(iii) complexes of a pyridine dianionic pincer ligand.	pyridine	88-96	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	68-71
28940713-3	2017	Switching the solvent to pyridine induces a remarkable change in the dehydrocoupling product ratio, with (NMe2 )2 BH favoured over [NMe2 BH2 ]2 (e.g., 94 %:2 % for 1tLi).	pyridine	25-33	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	132-136
29052412-0	2017	Co(II)-Doped Cd-MOF as an Efficient Water Oxidation Catalyst: Doubly Interpenetrated Boron Nitride Network with the Encapsulation of Free Ligand Containing Pyridine Moieties.	pyridine	156-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
28772058-3	2017	The significantly enhanced activity of 1-PPh3 /G, compared with that of its analogues 1-py/G (the Co-bound axial ligand is pyridine instead of triphenylphosphine) and 2-py/G (Co complex of 5,10,15-tris(pentafluorophenyl)corrole), highlights the effects of the pyrenyl substituent and the triphenylphosphine axial ligand on the HER activity.	pyridine	123-131	caveolin 1	Homo sapiens	41-45
29250408-2	2017	Each CoII ion is coordinated by two pyridine N atoms from two bridging L ligands, two O atoms from methanol mol-ecules and two chloride anions, all inversion-related.	pyridine	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-9
28960509-1	2017	An AgI dimer capped with labile organometallic diphosphorus ligands [Cp2 Mo2 (CO)4 (eta2 -P2 )] (Cp=C5 H5 ) acts as a highly pre-organized molecular precursor to direct the construction of 1D or 2D, and 3D organometallic-organic hybrid coordination polymers upon reaction with ditopic pyridine-based linkers.	pyridine	285-293	DNA polymerase iota	Homo sapiens	84-88
29068016-1	2017	Two porphyrin chromophores, P1 and P2, were prepared and used as antenna units to coordinate with a metal-free organic dye, JH1, containing pyridine groups.	pyridine	140-148	crystallin gamma F, pseudogene	Homo sapiens	28-37
29068016-1	2017	Two porphyrin chromophores, P1 and P2, were prepared and used as antenna units to coordinate with a metal-free organic dye, JH1, containing pyridine groups.	pyridine	140-148	immunoglobulin heavy joining 1	Homo sapiens	124-127
29052412-0	2017	Co(II)-Doped Cd-MOF as an Efficient Water Oxidation Catalyst: Doubly Interpenetrated Boron Nitride Network with the Encapsulation of Free Ligand Containing Pyridine Moieties.	pyridine	156-164	lysine acetyltransferase 8	Homo sapiens	16-19
29052412-2	2017	Herein, a novel strategy has been demonstrated for developing the OER electrocatalyst by doping Co(II) in to a three-dimensional Cd-based MOF that contains a naked pyridine moieties in the form of uncoordinated ligand.	pyridine	164-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
29052412-2	2017	Herein, a novel strategy has been demonstrated for developing the OER electrocatalyst by doping Co(II) in to a three-dimensional Cd-based MOF that contains a naked pyridine moieties in the form of uncoordinated ligand.	pyridine	164-172	lysine acetyltransferase 8	Homo sapiens	138-141
28990631-1	2017	The pyridine substituted thiourea derivative PTB-1 was synthesized and characterized by spectroscopic techniques as well as by single crystal X-ray crystallography.	pyridine	4-12	polypyrimidine tract binding protein 1	Homo sapiens	45-50
28852749-2	2017	The coordination polyhedron of the Co(ii) cations is a distorted octahedron built from two N and two S atoms of four equatorial NCS anions and two apical N atoms of the pyridine ligands.	pyridine	169-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
28672278-0	2017	Hydrazinyl arylthiazole based pyridine scaffolds: Synthesis, structural characterization, in vitro alpha-glucosidase inhibitory activity, and in silico studies.	pyridine	30-38	sucrase-isomaltase	Homo sapiens	99-116
28853885-5	2017	Key structural features interacting with KHK were discovered through fragment-based screening and subsequent optimization using structure-based drug design, and parallel medicinal chemistry led to the identification of pyridine 12.	pyridine	219-227	ketohexokinase	Homo sapiens	41-44
28813053-3	2017	The molecular structure of 2 adopted a square pyramidal geometry (tau = 0.2545), with the Cu-Npy bond (1.958 A) of its middle pyridine unit being shorter than the other two Cu-Nbenzim bonds (Cu-N, 1.995, 2.000 A).	pyridine	126-134	neuropeptide Y	Homo sapiens	93-96
28805382-3	2017	DFT calculations indicate that the close steric fitting between the rigid cavity of 1 and the pyridinium guest is the crucial factor for the stabilization of their supramolecular complex through C-H   pi and N+   pi1,4DMB interactions.	pyridine	94-104	karyopherin subunit alpha 1	Homo sapiens	195-221
28830649-1	2017	Herein we report identification of an imidazopyridine class of potent and selective TYK2 inhibitors, exemplified by prototype 6, through constraint of the rotatable amide bond connecting the pyridine and aryl rings of compound 1.	pyridine	45-53	tyrosine kinase 2	Homo sapiens	84-88
28916765-3	2017	This step requires protonation by a conserved aspartate of the pyridine nitrogen of PLP to enhance its ability to stabilize the carbanionic intermediate.	pyridine	63-71	pyridoxal phosphatase	Homo sapiens	84-87
28989683-2	2017	This is a rare example of catalytic, asymmetric addition of a nucleophile to the activated pyridinium that prefers C-4 functionalization leading to the 1,4-dihydropyridine with high selectivity.	pyridine	91-101	complement C4A (Rodgers blood group)	Homo sapiens	115-118
28625985-13	2017	Bacteria usually decompose nicotine using the classical strategy of hydroxylating the pyridine ring with the help of activated oxygen by nicotine dehydrogenase, which binds one molybdopterin, two [2Fe2S] clusters, and usually one flavin adenine dinucleotide (FAD) as well.	pyridine	86-94	hydroxyacid dehydrogenase	Agrobacterium tumefaciens	146-159
28776992-6	2017	Although aniline and pyridine derivatives interact with His342, benzonitriles conferred the best rat and human nNOS inhibition.	pyridine	21-29	nitric oxide synthase 1	Homo sapiens	111-115
28666737-2	2017	Several N-methoxyamides with thienopyrimidine and pyridine scaffolds showed potent GPR119 agonistic activities.	pyridine	50-58	G-protein coupled receptor 119	Mus musculus	83-89
28470883-3	2017	Diverse, fragment-sized 4-halopyridines inactivated human dimethylarginine dimethylaminohydrolase-1 (DDAH1) through covalent modification of the active site cysteine, acting as quiescent affinity labels that required off-pathway catalysis through stabilization of the protonated pyridinium by a neighboring aspartate residue.	pyridine	279-289	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	58-99
28470883-3	2017	Diverse, fragment-sized 4-halopyridines inactivated human dimethylarginine dimethylaminohydrolase-1 (DDAH1) through covalent modification of the active site cysteine, acting as quiescent affinity labels that required off-pathway catalysis through stabilization of the protonated pyridinium by a neighboring aspartate residue.	pyridine	279-289	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	101-106
28819390-2	2017	We recently found that fluorofenidone (FD), a newly developed pyridine compound, reduced the activation of Stat3 (Signal transducer and activator of transcription 3) in fibroblasts.	pyridine	62-70	signal transducer and activator of transcription 3	Homo sapiens	107-112
28533114-2	2017	Substitution of a pyridine ring of a serendipitously-identified Cdc7 inhibitor 2b with a 3-methylpyrazole resulted in a 4-fold increase in potency and acceptable kinase selectivity, leading to the identification of thieno[3,2-d]pyrimidin-4(3H)-one as an alternative scaffold.	pyridine	18-26	cell division cycle 7	Homo sapiens	64-68
28605176-1	2017	The organoiridium(III) complex (Ir(III)) [(eta5-Cpxbiph)Ir(phpy) (py)]PF6 containing pi-bonded biphenyltetramethylcyclopentadienyl(Cpxbiph), C N-chelated phenylpyridine(phpy), and pyridine (py) ligands has more potent antitumor activity as a new generation of drug than cisplatin toward various cancer cells.	pyridine	61-63	sperm associated antigen 17	Homo sapiens	70-73
28819390-2	2017	We recently found that fluorofenidone (FD), a newly developed pyridine compound, reduced the activation of Stat3 (Signal transducer and activator of transcription 3) in fibroblasts.	pyridine	62-70	signal transducer and activator of transcription 3	Homo sapiens	114-164
28434782-6	2017	Two important controls, mono-triazole 5 and pyridine 6, also were examined, indicating that the triazole - incorporated as part of the click assembly as a spacer - contributes to MDR-1 binding.	pyridine	44-52	ATP binding cassette subfamily B member 1	Homo sapiens	179-184
28395195-2	2017	To confirm our hypothesis, we synthesized a copper(II) compound derived from 2-amino-5-chlorophenol 2-hydroxybenzaldehyde Schiff-base, containing a leaving group [pyridine, PRD], namely Cu(L)(PRD).	pyridine	163-171	PRD	Homo sapiens	192-195
28395195-3	2017	The HSA complex structure revealed that Cu(L)(PRD) binds to the hydrophobic cavity in HSA IIA sub-domain, His242 of HSA replaces the pyridine ligand in Cu compound, coordinating with Cu2+.	pyridine	133-141	PRD	Homo sapiens	46-49
28412159-0	2017	Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors.	pyridine	40-48	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	87-92
28412159-1	2017	In this study, a series of novel pyridine and pyrimidine-containing derivatives were designed, synthesized and biologically evaluated for their c-Met inhibitory activities.	pyridine	33-41	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	144-149
28513168-3	2017	Capitalizing on the heteroleptic pyridyl and phenanthroline metal complexes concept, the rotator"s pyridine terminals are connected to the copper(I)-loaded phenanthroline stations (Npy   [Cu(phen)]+) in the STOP state and disconnected in the transition state of rotation.	pyridine	99-107	neuropeptide Y	Homo sapiens	181-184
28496125-6	2017	These hurdles were overcome by successfully identifying a pyridinium-based cationic lipid formulation, which significantly improved the activity of the stapled peptide in a p53 reporter cell line, principally through increased vesicular escape.	pyridine	58-68	tumor protein p53	Homo sapiens	173-176
28232482-5	2017	We demonstrate that this hydrogen bond network directly influences the protonation state of the pyridine nitrogen of PLP, which affects the rates of catalysis.	pyridine	96-104	pyridoxal phosphatase	Homo sapiens	117-120
28368589-2	2017	The nucleophilic CH2 group generated by the deprotonation attacks the 6 (bipy) or 2 (phen) positions of the diimines, dearomatizing the involved pyridine ring and generating new asymmetric, fac-capping tridentate ligands.	pyridine	145-153	FA complementation group C	Homo sapiens	190-193
28232482-7	2017	Protonation of the pyridinyl nitrogen to form a pyridinium cation induces electronic delocalization in the PLP, which correlates with the enhancement in catalytic rate in AAT.	pyridine	48-58	pyridoxal phosphatase	Homo sapiens	107-110
28270133-12	2017	CONCLUSIONS: Results presented herein confirm previously published data on the anticancer activity of pyridine compounds and demonstrate that 1,4-DMP may be beneficially implemented into chemotherapy utilizing various cytotoxic agents, directed against multiple metastatic tumor types.	pyridine	102-110	dentin matrix protein 1	Mus musculus	146-149
29086809-8	2017	CONCLUSION: Novel compounds were obtained with good anticancer and antibacterial activity especially fluorinated pyridine derivative 4a and molecular docking study suggest good activity as mitogen activated protein kinase-2 inhibitor.	pyridine	113-121	mitogen-activated protein kinase 1	Homo sapiens	189-223
28262884-1	2017	[CuCl(PPh3)2(4-Mepy)] (PPh3 = triphenylphosphine, 4-Mepy = 4-methylpyridine), a highly blue-luminescent mononuclear copper(i) complex, shows reversible emission colour change ranging from blue-green to red by vapour exposure to N-heteroaromatics, such as pyridine, pyrimidine, and 2-methylpyrazine.	pyridine	67-75	caveolin 1	Homo sapiens	6-10
28089883-1	2017	Vitamin B6 comprises six interconvertible pyridine compounds, among which pyridoxal 5"-phosphate (PLP) is a coenzyme for over 140 enzymes.	pyridine	42-50	pyridoxal phosphatase	Homo sapiens	98-101
27858300-3	2017	The absorption and fluorescence of HMP-PDIs have been tuned by make use of pyridine isomers.	pyridine	75-83	inner membrane mitochondrial protein	Homo sapiens	35-38
28059509-3	2017	To increase structural diversity of this class of CB1 ligands, we designed and synthesized two classes of novel analogues, in which the pyridine ring of 2 was replaced by a pyrimidine ring.	pyridine	136-144	cannabinoid receptor 1	Homo sapiens	50-53
28177027-1	2017	This communication presents a structure-property study of a few novel pyridine-based difluoroborate compounds with a N-BF2-O core, which exhibit outstanding fluorescence properties.	pyridine	70-78	forkhead box G1	Homo sapiens	119-122
27859755-2	2017	In this research, the achiral amphiphile 1-[11-(2-anthracenylmethoxy)-11-oxoundecyl]pyridinium bromide (2-APB), in which the hydrophobic anthracene and the hydrophilic pyridinium units are linked by alkyl chains, was found to form chiral supramolecular assemblies in a cooperative manner in the presence of iodide anion.	pyridine	84-94	arginyl aminopeptidase	Homo sapiens	106-109
28011426-0	2017	Improving potency and metabolic stability by introducing an alkenyl linker to pyridine-based histone deacetylase inhibitors for orally available RUNX3 modulators.	pyridine	78-86	RUNX family transcription factor 3	Homo sapiens	145-150
28011426-5	2017	In the present study, we introduced an alkenyl linker group to pyridine-based HDAC inhibitors to improve their potencies and chemical properties.	pyridine	63-71	histone deacetylase 9	Homo sapiens	78-82
28134790-3	2017	Density functional theory (DFT) studies were carried out for the pyridine derivatives 2a-2i and 4a-4i by using B3LYP/6-31G(d,p) basis with the help of GAUSSIAN 09 suite programme.	pyridine	65-73	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	113-116
27966348-3	2017	The first step is coordination of the pyridine-AlMe3 adduct with the active species Ni(0)(NHC)(C2H2) 1 in an eta2-fashion to form an intermediate Int1.	pyridine	38-46	Wnt family member 1	Homo sapiens	146-150
27966348-4	2017	After the isomerization of Int1, the oxidative addition of the C-H bond of pyridine across the nickel-acetylene moiety occurs via a transition state TS2 to form a Ni(II)(NHC) pyridyl vinyl intermediate Int3.	pyridine	75-83	Wnt family member 1	Homo sapiens	27-31
27966348-4	2017	After the isomerization of Int1, the oxidative addition of the C-H bond of pyridine across the nickel-acetylene moiety occurs via a transition state TS2 to form a Ni(II)(NHC) pyridyl vinyl intermediate Int3.	pyridine	75-83	notch receptor 4	Homo sapiens	202-206
27456766-4	2017	METHODS: We have expressed CYP2U1 in E. coli and performed UV-vis and EPR spectroscopy experiments with purified CYP2U1 alone and in the presence of substrates and imidazole and pyridine derivatives.	pyridine	178-186	cytochrome P450 family 2 subfamily U member 1	Homo sapiens	27-33
28473879-3	2017	Thus, tested DHPs belong to three groups: (1) antioxidant diludine; (2) derivatives with pyridinium moieties at position 4 of the 1,4-DHP ring; (3) DHPs containing cationic methylene onium (pyridinium, trialkylammonium) moieties at positions 2 and 6 of the 1,4-DHP ring.	pyridine	89-99	dihydropyrimidinase	Homo sapiens	13-16
28473879-3	2017	Thus, tested DHPs belong to three groups: (1) antioxidant diludine; (2) derivatives with pyridinium moieties at position 4 of the 1,4-DHP ring; (3) DHPs containing cationic methylene onium (pyridinium, trialkylammonium) moieties at positions 2 and 6 of the 1,4-DHP ring.	pyridine	190-200	dihydropyrimidinase	Homo sapiens	13-16
27299481-4	2016	The NO-induced aromatization of dihydropyridine in DHPS to pyridine derivative (PYS) proved to be the switching mechanism for the fluorescent sensing process, which was confirmed through spectra characterization and computation study.	pyridine	39-47	deoxyhypusine synthase	Mus musculus	51-55
27798827-2	2016	The combination of the replacement of a pyridine ring of 9 with a pyrimidine ring and the introduction of an additional fluorine substituent at the 2-position of the phenyl ring resulted in the discovery of a potent, selective, and orally bioavailable inhibitor, 18a (SKI2852), which demonstrated no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity.	pyridine	40-48	peptidyl-prolyl isomerase G (cyclophilin G)	Mus musculus	300-303
27775741-1	2016	We describe the structural and electronic impacts of modifying the bridging atom in a family of Co(ii) pincer complexes with the formula Co(t-Bu)2PEPyEP(t-Bu)2Br2 (Py = pyridine, E = CH2, NH, and O for compounds 1-3, respectively).	pyridine	148-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
27775741-1	2016	We describe the structural and electronic impacts of modifying the bridging atom in a family of Co(ii) pincer complexes with the formula Co(t-Bu)2PEPyEP(t-Bu)2Br2 (Py = pyridine, E = CH2, NH, and O for compounds 1-3, respectively).	pyridine	169-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
27798827-2	2016	The combination of the replacement of a pyridine ring of 9 with a pyrimidine ring and the introduction of an additional fluorine substituent at the 2-position of the phenyl ring resulted in the discovery of a potent, selective, and orally bioavailable inhibitor, 18a (SKI2852), which demonstrated no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity.	pyridine	40-48	nuclear receptor subfamily 1, group I, member 2	Mus musculus	308-311
28167882-1	2016	A pyridine-functionalized thin film has been fabricated to selectively preconcentrate Cr(VI) anions for electrochemical detection in the 5-300 mug L-1 range.	pyridine	2-10	immunoglobulin kappa variable 1-16	Homo sapiens	147-150
27802043-1	2016	A scalable and efficient synthesis of the GPR40 agonist MK-8666 was developed from a simple pyridine building block.	pyridine	92-100	free fatty acid receptor 1	Homo sapiens	42-47
27768301-2	2016	(S)-Nicotine and (S)-6-chloronicotine derivatives were cross-coupled with the corresponding amides 6-10 at the C-4 position of the pyridine ring via copper(I)-mediated reactions.	pyridine	131-139	complement C4A (Rodgers blood group)	Homo sapiens	111-114
27727356-1	2016	The pincer complex (PNN)RuH(CO), with a de-aromatized pyridine in the ligand backbone, is shown to react with nitriles in a metal-ligand cooperative manner.	pyridine	54-62	pinin, desmosome associated protein	Homo sapiens	20-23
27774543-1	2016	Taking a natural triterpenoid as the building block, we have regulated a pyridinium-functionalized methyl glycyrrhetate (C4-MGP) into P-type helices in water primarily driven by hydrophobic forces.	pyridine	73-83	matrix Gla protein	Homo sapiens	124-127
27576294-2	2016	Several pyridine-based compounds modeled after known small molecule CXCR4 antagonists, AMD3100 and WZ811, were synthesized.	pyridine	8-16	C-X-C motif chemokine receptor 4	Homo sapiens	68-73
27576294-7	2016	These preliminary results are the promising foundation of a new class of pyridine-based CXCR4 antagonists.	pyridine	73-81	C-X-C motif chemokine receptor 4	Homo sapiens	88-93
27722364-2	2016	Treatment of the square-planar [Pd(CNP)Cl](AgCl2) complex 2a with KHMDS produces the selective deprotonation at the CH2P arm of the pincer to yield the pyridine-dearomatised complex 3a.	pyridine	152-160	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	35-38
27660855-2	2016	Described in this manuscript are the discovery, optimization, and in vivo evaluation of a novel series of pyridine-containing PI3Kdelta inhibitors.	pyridine	106-114	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	126-135
27539781-3	2016	Glass surfaces have been functionalized with pyridine-terminated SAMs and subsequently with multilayers of macrocycles through layer-by-layer self assembly.	pyridine	45-53	methionine adenosyltransferase 1A	Homo sapiens	65-69
27386853-2	2016	The ssDNA binding of the homolog YdbC from Lactococcus lactis was previously characterized when bound to a 20-mer of pyridine-rich ssDNA, sharing an overall similar structural fold with the human transcription coactivator PC4.	pyridine	117-125	keratin 6B	Homo sapiens	222-225
27389312-3	2016	It has been proposed that NNMT may possess beta-carboline (BC) N-methyltransferase activity, endogenously and exogenously produced pyridine-containing compounds which, when N-methylated, are potent inhibitors of Complex I and have been proposed to have a role in the pathogenesis of Parkinson"s disease.	pyridine	131-139	nicotinamide N-methyltransferase	Homo sapiens	26-30
27265400-8	2016	The results indicated that one alpha-H on pyridine ring of cyprodinil was hydroxylated to form TPs 1.	pyridine	42-50	tryptase alpha/beta 1	Homo sapiens	95-100
27450300-4	2016	The pyridine containing water soluble complexes (CuL(1) and CuL(3)) are much more cytotoxic than the corresponding pyrrole counterparts (CuL(2) and CuL(4)).	pyridine	4-12	cullin 1	Homo sapiens	49-55
27570878-2	2016	Employing the cofactor S-adenosyl-l-methionine, NNMT transfers a methyl group to the pyridine nitrogen of nicotinamide to generate N-methylnicotinamide.	pyridine	85-93	nicotinamide N-methyltransferase	Homo sapiens	48-52
27570878-3	2016	Interestingly, NNMT is also able to N-methylate a variety of other pyridine-containing small molecules, suggesting a secondary role for the enzyme in the detoxification of xenobiotics.	pyridine	67-75	nicotinamide N-methyltransferase	Homo sapiens	15-19
27570878-7	2016	We successfully demonstrated the general applicability of the method by performing kinetic analyses of NNMT-mediated methylation for a range of pyridine-based substrates.	pyridine	144-152	nicotinamide N-methyltransferase	Homo sapiens	103-107
27500422-3	2016	In both structures, the Co(II) centers adopt octahedral {CoN2O4} geometries filled by pairs of mutually trans terminal 3,5-dnb, py, and water ligands.	pyridine	128-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
27541271-5	2016	A spirocyclic central motif was thus discovered that was combined with left-hand pyridines (or pyridine-like systems) to provide cellularly potent NAMPT inhibitors with minimal CYP2C9 inhibition.	pyridine	81-89	nicotinamide phosphoribosyltransferase	Mus musculus	147-152
27491352-4	2016	The synergistic roles of pyridine and the (ClPh)N4 ligand in promoting B-F abstraction were clarified by the isolation and crystallization of the simple tetrakis-pyridine monomeric complex [Co(py)4(MeCN)2](BF4)2 (4) [no B-F abstraction]; subsequent addition of the (ClPh)N4 ligand to 4 resulted in formation of the dimeric, di-bridged complex 2.	pyridine	25-33	calcium binding protein, spermatid associated 1	Homo sapiens	266-270
27450300-4	2016	The pyridine containing water soluble complexes (CuL(1) and CuL(3)) are much more cytotoxic than the corresponding pyrrole counterparts (CuL(2) and CuL(4)).	pyridine	4-12	cullin 3	Homo sapiens	60-66
27335216-4	2016	Thus, cationic species with additional DMSO or pyridine coordinated could be collected for the DMSO and PPh3 derivatives.	pyridine	47-55	caveolin 1	Homo sapiens	104-108
27265247-3	2016	The systematic change of electron density of the pyridine nitrogens upon alteration of the para-substituent (NO2, CF3, H, F, Me, OMe, NMe2) was confirmed by (15)N NMR and by computation of the natural atomic population and the pi electron population of the nitrogen atoms.	pyridine	49-57	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	134-138
28111599-0	2016	Nickel-Catalyzed C-3 Direct Arylation of Pyridinium Ions for the Synthesis of 1-Azafluorenes.	pyridine	41-51	complement C3	Homo sapiens	17-20
28111599-2	2016	The first nickel-catalyzed C-3 direct arylation of pyridine derivatives to provide a new approach to valuable 1-azafluorene pharmacophore frameworks was developed.	pyridine	51-59	complement C3	Homo sapiens	27-30
27335216-5	2016	The PPr3 derivative traps out the reactive five-coordinate species with an agostic interaction that subsequently induces a transcyclometallation reaction to give a complex with a singly cyclometallated pyridine and a cyclometallated phosphine, which was characterised crystallographically, (6c	pyridine	202-210	PPR3	Homo sapiens	4-8
27315353-1	2016	The synthesis of enantiomerically pure pyridine-bridged phosphaalkene-oxazolines ArP C(Ph)(2,6-C5H3NOx) (1, Ar = Mes/Mes*, Ox = CNOCH(i-Pr)CH2/CNOCH(CH2Ph)CH2) is reported.	pyridine	39-47	ADP ribosylation factor related protein 1	Homo sapiens	81-84
26994364-1	2016	A series of C1-, C2-and C3-symmetric pyridinium conjugates with different styrene-like side groups were synthesized and were utilized as G-quadruplex selective fluorescent probes.	pyridine	37-47	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	12-26
27313760-0	2016	Pyridine analogues of curcumin exhibit high activity for inhibiting CWR-22Rv1 human prostate cancer cell growth and androgen receptor activation.	pyridine	0-8	androgen receptor	Homo sapiens	116-133
26800298-9	2016	Our results indicate that, unlike in aqueous solution, the PLP pyridine moiety is protonated in GABA-AT.	pyridine	63-71	pyridoxal phosphatase	Homo sapiens	59-62
26800298-9	2016	Our results indicate that, unlike in aqueous solution, the PLP pyridine moiety is protonated in GABA-AT.	pyridine	63-71	4-aminobutyrate aminotransferase	Homo sapiens	96-103
26800298-11	2016	In addition, our MD simulations exhibit additional strong hydrogen bond networks between the protein and PLP: the phosphate group is held in place by the donation of at least three hydrogen bonds while the carbonyl oxygen of the pyridine ring interacts with Gln301; Phe181 forms a pi-pi stacking interaction with the pyridine ring and works as a gate keeper with the assistance of Val300.	pyridine	229-237	pyridoxal phosphatase	Homo sapiens	105-108
26800298-11	2016	In addition, our MD simulations exhibit additional strong hydrogen bond networks between the protein and PLP: the phosphate group is held in place by the donation of at least three hydrogen bonds while the carbonyl oxygen of the pyridine ring interacts with Gln301; Phe181 forms a pi-pi stacking interaction with the pyridine ring and works as a gate keeper with the assistance of Val300.	pyridine	317-325	pyridoxal phosphatase	Homo sapiens	105-108
27061986-4	2016	Here we describe a new class of potent S1PR1 agonists wherein the exocyclic nitrogen was moved away from the pyridine ring (e.g. 11c).	pyridine	109-117	sphingosine-1-phosphate receptor 1	Rattus norvegicus	39-44
27231731-7	2016	We also describe the first 2D NMR assignment of striatin C. Pyristriatins A and B are the first cyathane natural products featuring a pyridine ring.	pyridine	134-142	striatin	Homo sapiens	48-56
27244471-6	2016	The coordination of pyridine to the cobalt(ii) centre diminished the peak current at the Epc value of the Co(I/0) redox couple, which was indicative of the relative position of the reaction equilibrium.	pyridine	20-28	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	106-112
27073051-1	2016	Pyridine-based Factor XIa (FXIa) inhibitor (S)-2 was optimized by modifying the P2 prime, P1, and scaffold regions.	pyridine	0-8	proteasome 26S subunit ubiquitin receptor, non-ATPase 2	Homo sapiens	15-48
27050842-0	2016	Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.	pyridine	130-138	nitric oxide synthase 1	Homo sapiens	27-57
27050842-3	2016	Here we report potent and selective human nNOS inhibitors based on the 2-aminopyridine scaffold with a central pyridine linker.	pyridine	78-86	nitric oxide synthase 1	Homo sapiens	42-46
27143338-0	2016	CF3 Derivatives of the Anticancer Ru(III) Complexes KP1019, NKP-1339, and Their Imidazole and Pyridine Analogues Show Enhanced Lipophilicity, Albumin Interactions, and Cytotoxicity.	pyridine	94-102	albumin	Homo sapiens	142-149
29997819-6	2016	The reduction of these CoIII complexes yields LSCoII and LSCoI species in which the pyridine acts as the dominant axial ligand.	pyridine	84-92	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	23-28
27187326-0	2016	Discovery of Potent c-MET Inhibitors with New Scaffold Having Different Quinazoline, Pyridine and Tetrahydro-Pyridothienopyrimidine Headgroups.	pyridine	85-93	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	20-25
27046462-1	2016	Reaction of carbene-stabilized diphosphorus, L:P-P:L (5) (L: = :C{N(2,6-Pr(i)2C6H3)CH}2) with pyridine hydrochloride yields [L:(H)P-P:L]Cl (6), a salt containing the HP2(+) cation--the elusive phosphorus analogue of the well known diazonium cation, HN2(+).	pyridine	94-116	MT-RNR2 like 2 (pseudogene)	Homo sapiens	249-252
26860459-7	2016	Moreover, cortisol, acting through 11beta-HSD1, begets a more reduced pyridine redox ratio.	pyridine	70-78	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	35-46
26624276-10	2016	The aromaticity in pyridine, isoxazole and furan bound Au3(+) complexes is quite comparable with that in the recently synthesized Zn3(C5(CH3)5)3(+).	pyridine	19-27	complement C5	Homo sapiens	130-136
26874345-0	2016	Synthesis and antiproliferative activity of benzophenone tagged pyridine analogues towards activation of caspase activated DNase mediated nuclear fragmentation in Dalton"s lymphoma.	pyridine	64-72	DNA fragmentation factor, beta subunit	Mus musculus	105-128
27088605-10	2016	In addition to alkynes, nitriles (RC N), although non-participants in aza-HDDA reactions, readily function as the 2pi component in PDDA cyclizations to produce, via trapping of the alpha,3-(5-aza)dehydrotoluene intermediates, pyridine-containing products.	pyridine	226-234	reticulocalbin 1	Homo sapiens	34-38
27027319-5	2016	On the basis of halogen substitution, the substitution of terminal benzene ring of triisopropyl-silylethynyl-pentacene (TIPS-PEN) by a thiophene or pyridine will greatly lower the LUMO level and improve the stacking mode, leading to more suitable ambipolar materials.	pyridine	148-156	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	125-128
26419539-1	2016	An original mixed ligand (labelled L) of formula PPh2-CH2-Pyr-CH2-N[double bond, length as m-dash]PPh3, combining a pyridine core with phosphine and iminophosphorane, was synthesised.	pyridine	116-124	protein phosphatase 4 catalytic subunit	Homo sapiens	98-102
26827140-3	2016	Pyridine-containing compounds were more selective toward BChE; compounds with the para-OMe substituent in one of the two dibenzyl fragments were more selective toward CaE.	pyridine	0-8	butyrylcholinesterase	Homo sapiens	57-61
26859865-4	2016	Pyridine and pyrazine derivatives appear to have a similar ~1.2 Hz (4)J coupling to p-H2 derived hydrides for their ortho protons, and a much lower (5)J coupling for their meta protons.	pyridine	0-8	polyhomeotic homolog 2	Homo sapiens	84-88
26871934-0	2016	Scaffold Hopping Approach to a New Series of Pyridine Derivatives as Potent Inhibitors of CDK2.	pyridine	45-53	cyclin dependent kinase 2	Homo sapiens	90-94
26871934-1	2016	A scaffold hopping approach was exploited to guide the discovery of a series of pyridine derivatives as novel cyclin-dependent kinase (CDK2) inhibitors.	pyridine	80-88	cyclin dependent kinase 2	Homo sapiens	135-139
26637323-1	2016	In a preceding work with dopant assisted-atmospheric pressure photoionization (DA-APPI), an abundant ion at [M + 77](+) was observed in the spectra of pyridine and quinoline with chlorobenzene dopant.	pyridine	151-159	amyloid beta precursor protein	Homo sapiens	82-86
26862859-0	2016	Absorption intensity changes and frequency shifts of fundamental and first overtone bands for OH stretching vibration of methanol upon methanol-pyridine complex formation in CCl4: analysis by NIR/IR spectroscopy and DFT calculations.	pyridine	144-152	C-C motif chemokine ligand 4	Homo sapiens	174-178
26846498-0	2016	Two-dimensional Zn(II) and one-dimensional Co(II) coordination polymers based on benzene-1,4-dicarboxylate and pyridine ligands.	pyridine	111-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
26270719-2	2016	As cangrelor is administered intravenously, it is necessary to switch to an oral P2Y12 antagonist following PCI, such as the thienopyridines clopidogrel, and prasugrel or the non-pyridine ticagrelor.	pyridine	131-139	purinergic receptor P2Y12	Homo sapiens	81-86
26633597-2	2016	We utilized tip-enhanced Raman spectroscopy (TERS) to address the challenge in probing the subtle change of the intermolecular interaction during the assembly of a pyridine-terminated aromatic thiol on the single crystal Au(111) surface that cannot produce enhanced Raman signal, together with electrochemical methods to study the charge transfer properties of SAM.	pyridine	164-172	TOR signaling pathway regulator	Homo sapiens	12-15
26764191-4	2016	In the pyridine series, compound 7a was found to be a highly potent and selective EP4 antagonist, with suitable rat and dog pharmacokinetic profiles.	pyridine	7-15	prostaglandin E receptor 4	Rattus norvegicus	82-85
27581632-1	2016	A series of pyridinium salts bearing alkylphenyl groups at 1 position and hydrazone structure at 4 position of the pyridinium ring were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes.	pyridine	12-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	189-209
27581632-1	2016	A series of pyridinium salts bearing alkylphenyl groups at 1 position and hydrazone structure at 4 position of the pyridinium ring were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes.	pyridine	12-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	211-215
27581632-1	2016	A series of pyridinium salts bearing alkylphenyl groups at 1 position and hydrazone structure at 4 position of the pyridinium ring were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes.	pyridine	12-22	butyrylcholinesterase	Homo sapiens	221-242
27581632-1	2016	A series of pyridinium salts bearing alkylphenyl groups at 1 position and hydrazone structure at 4 position of the pyridinium ring were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes.	pyridine	12-22	butyrylcholinesterase	Homo sapiens	244-249
26569517-3	2015	Since this reaction is barrier-less, pyridine can also be synthesized via this bimolecular reaction in cold molecular clouds such as in TMC-1.	pyridine	37-45	transmembrane channel like 1	Homo sapiens	136-141
26636830-16	2015	Both correlated CASSCF/NEVPT2 and spin-unrestricted B3LYP-based DFT calculations show a significant delocalization of the spin density from the Co(I) dxz,yz orbitals toward the empty pi* orbitals located on the two central pyridine fragments in the trans position.	pyridine	223-231	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	144-149
26494532-5	2015	The SMD simulations showed that the active pyridinium ring of K048 is directed towards the phosphorus atom conjugated to the active serine (SUN203) of tabun-mAChE(wild-type).	pyridine	43-53	acetylcholinesterase	Mus musculus	157-162
26494532-7	2015	However, in the case of tabun-mutant mAChE(Y337A).K048 conjugate, the replacement of aromatic Tyr337 with the aliphatic alanine unit in the choline binding site, however, loses one of the pi-pi interaction between the active pyridinium ring of K048 and the Tyr337.	pyridine	225-235	acetylcholinesterase	Mus musculus	37-42
26494532-10	2015	Furthermore, the unbinding of the K048 with SMD studies showed that the active pyridinium ring of the drug undergoes a complete turn along the gorge axis and is directed away from the phosphorus atom conjugated to the active serine of the tabun-mutant mAChE(Y337A).	pyridine	79-89	acetylcholinesterase	Mus musculus	252-257
26338723-0	2015	Metal complexes of pyridine-fused macrocyclic polyamines targeting the chemokine receptor CXCR4.	pyridine	19-27	C-X-C motif chemokine receptor 4	Homo sapiens	90-95
26476186-2	2015	The Pd/C catalyst mediated dehydrogenation of diosgenin generated the 1,4,6-trien-3-one (3), which was reacted with Ac2O in pyridine in the presence of a catalytic amount of POCl3 followed by hydrolysis to give the 22-hydroxyfurostan (4) in 65% yield.	pyridine	124-132	adenylate cyclase 2	Homo sapiens	116-119
26442797-1	2015	A series of luminescent fac-[Re(CO)3(L)(NN)](+) complexes, where L is a pyridine or an imidazole and NN is the 1,10-phenanthroline subunit of mixed donor pentadentate thioether crowns have been synthesised and their luminescence properties have been analysed.	pyridine	72-80	FA complementation group C	Homo sapiens	24-27
26567670-4	2015	Our calculations imply a structure for [Co(Pyridine)(CO2)](-) in which a central cobalt atom is bound to pyridine and CO2 moieties on either sides.	pyridine	105-113	complement C2	Homo sapiens	53-56
26426827-1	2015	syn-Diastereoselective conjugate addition of 1-pyrroline esters to nitroalkenes in good yields with an excellent enantioselectivity by using CuOAc/Me-FcPHOX catalyst in the presence of pyridine.	pyridine	185-193	synemin	Homo sapiens	0-3
26411800-3	2015	The absorption and emission spectra of compounds 1-4 and 6 were measured and observed that the absorption and emission depends on the substituent at C-6 and C-7 position of pyridine ring in naphthyridines skeleton 6.	pyridine	173-181	complement C6	Homo sapiens	149-152
26411800-3	2015	The absorption and emission spectra of compounds 1-4 and 6 were measured and observed that the absorption and emission depends on the substituent at C-6 and C-7 position of pyridine ring in naphthyridines skeleton 6.	pyridine	173-181	complement C7	Homo sapiens	157-160
26333094-6	2015	Emphasizing the criticalness of stoichiometry, reaction of nBuLi/Me6 TREN with two equivalents of pyridine results in non-alkylated 1-lithio-1,4-dihydropyridine Me6 TREN and 2-n-butylpyridine, implying mechanistically the kinetic 1,2-n-butyl intermediate hydrolithiates the second pyridine.	pyridine	98-106	protocadherin gamma subfamily B, 7	Homo sapiens	65-68
26393962-2	2015	Interestingly enough, the pyridine based trans-(1-3)b complexes and a PPh3 derived cis-3c complex exhibited higher yields than the related PPh3 derived trans-(1-2)c complexes.	pyridine	26-34	protein phosphatase 4 catalytic subunit	Homo sapiens	139-143
26360048-1	2015	Within the constantly growing number of histamine H4 (H4R) receptor ligands there is a large group of azine derivatives.	pyridine	102-107	histamine receptor H4	Homo sapiens	54-57
26333094-6	2015	Emphasizing the criticalness of stoichiometry, reaction of nBuLi/Me6 TREN with two equivalents of pyridine results in non-alkylated 1-lithio-1,4-dihydropyridine Me6 TREN and 2-n-butylpyridine, implying mechanistically the kinetic 1,2-n-butyl intermediate hydrolithiates the second pyridine.	pyridine	98-106	protocadherin gamma subfamily B, 7	Homo sapiens	161-164
26333094-6	2015	Emphasizing the criticalness of stoichiometry, reaction of nBuLi/Me6 TREN with two equivalents of pyridine results in non-alkylated 1-lithio-1,4-dihydropyridine Me6 TREN and 2-n-butylpyridine, implying mechanistically the kinetic 1,2-n-butyl intermediate hydrolithiates the second pyridine.	pyridine	152-160	protocadherin gamma subfamily B, 7	Homo sapiens	65-68
26333094-6	2015	Emphasizing the criticalness of stoichiometry, reaction of nBuLi/Me6 TREN with two equivalents of pyridine results in non-alkylated 1-lithio-1,4-dihydropyridine Me6 TREN and 2-n-butylpyridine, implying mechanistically the kinetic 1,2-n-butyl intermediate hydrolithiates the second pyridine.	pyridine	152-160	protocadherin gamma subfamily B, 7	Homo sapiens	161-164
26308773-4	2015	We report here crystal structures, cyclic voltammetry, UV-vis, IR, Raman, and (1)H NMR spectra for the complexes Rh2(esp)2L2 where L = pyridine, 3-picoline, 2,6-lutidine, acetonitrile, and methanol.	pyridine	135-143	Rh associated glycoprotein	Homo sapiens	113-116
28757942-2	2015	Subsequently, a unique C(sp2)-C(sp2) coupling of 2-phenylpyridine proceeded through a bimetallic yttrium intermediate, derived from an intramolecular shift of the yttrium center to an ortho-position of the pyridine ring in 3a, to yield a bimetallic yttrium complex (4a) bridged by two-electron reduced 6,6"-diphenyl-2,2"-bipyridyl.	pyridine	57-65	Sp2 transcription factor	Homo sapiens	23-28
28757942-3	2015	Aryl substituents at the ortho-position of the pyridine ring were key in order to destabilize the mu,kappa2-(C,N)-pyridyldiyttrium intermediate prior to the C(sp2)-C(sp2) bond formation.	pyridine	47-55	Sp2 transcription factor	Homo sapiens	157-162
28757942-3	2015	Aryl substituents at the ortho-position of the pyridine ring were key in order to destabilize the mu,kappa2-(C,N)-pyridyldiyttrium intermediate prior to the C(sp2)-C(sp2) bond formation.	pyridine	47-55	Sp2 transcription factor	Homo sapiens	164-169
26224106-7	2015	The BDEs of all five-membered-ring heterocyclics studied fall within the 116-120 kcal/mol range, contrasting the lower BDE = 110.4(2.0) kcal/mol of the more aromatic six-membered-ring pyridine.	pyridine	184-192	homeobox D13	Homo sapiens	4-7
26185800-0	2015	Sensitive and selective detection of uracil-DNA glycosylase activity with a new pyridinium luminescent switch-on molecular probe.	pyridine	80-90	uracil DNA glycosylase	Homo sapiens	37-59
25787859-3	2015	Further, molecular docking revealed that compound 5d could retain key binding features of DPP-4 with the pyridine moiety of imidazo[1,2-a]pyridine ring providing an additional pi-pi interaction with Phe357 of DPP-4.	pyridine	105-113	dipeptidyl peptidase 4	Homo sapiens	90-95
26308773-6	2015	Taking these data into account we find that the strength of axial ligand binding to Rh2(esp)2 increases in the series CH3OH ~ 2,6-lutidine &lt; CH3CN &lt; 3-methylpyridine ~ pyridine.	pyridine	163-171	Rh associated glycoprotein	Homo sapiens	84-87
25970648-10	2015	These potentials are shifted to significantly higher potentials (by ~0.45 V) than the literature values for the corresponding Fe(II) and Co(II) complexes of the equivalent all-pyridine ligand, consistent with replacement of the two pyridine rings by two pyrazine rings significantly stabilizing the lower oxidation states.	pyridine	176-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
26079043-1	2015	Following our discovery of human dihydroorotate dehydrogenase (DHODH) inhibition by 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as well as 2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)-5-methylpyridine, we describe here the syntheses and evaluation of an array of azine-bearing analogues.	pyridine	272-277	dihydroorotate dehydrogenase (quinone)	Homo sapiens	33-61
26079043-1	2015	Following our discovery of human dihydroorotate dehydrogenase (DHODH) inhibition by 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as well as 2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)-5-methylpyridine, we describe here the syntheses and evaluation of an array of azine-bearing analogues.	pyridine	272-277	dihydroorotate dehydrogenase (quinone)	Homo sapiens	63-68
25982075-8	2015	SAR study suggested that incorporation of 3-trifluoromethyl and methylamine carbonyl on terminal pyridine could improve VEGFR-2 inhibitory activity.	pyridine	97-105	kinase insert domain receptor	Homo sapiens	120-127
26120733-2	2015	Introduction of an N-methylethane-1,2-diamine side chain and conformational constraints such as benzonitrile and pyridine as the middle aromatic linker were sufficient to increase human and rat nNOS binding affinity and inducible and endothelial NOS selectivity.	pyridine	113-121	nitric oxide synthase 1	Rattus norvegicus	194-198
26079939-3	2015	A symmetric pyridine-containing tetraaminodiborane(4) compound (1) was readily prepared as the ligand precursor that could be used, in combination with [Ir(OMe)(COD)]2, to in situ generate a highly active catalyst for a broad range of (hetero)arene substrates including highly electron-rich and/or sterically hindered ones.	pyridine	12-20	COD2	Homo sapiens	161-167
26039570-0	2015	Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.	pyridine	59-67	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	86-90
25981685-3	2015	Judicious selection of the substituents on the pyridine ring and benzamide groups led to 6b; which was highly potent, OX2R selective, and exhibited excellent development properties.	pyridine	47-55	hypocretin receptor 2	Homo sapiens	118-122
25925332-4	2015	More interestingly, along with the morphological change, the fluorescence of the assemblies was enhanced concomitantly, which can be attributed to the binding effect of acetate ions on pyridinium head groups of PRB.	pyridine	185-195	RB transcriptional corepressor 1	Homo sapiens	211-214
25970648-10	2015	These potentials are shifted to significantly higher potentials (by ~0.45 V) than the literature values for the corresponding Fe(II) and Co(II) complexes of the equivalent all-pyridine ligand, consistent with replacement of the two pyridine rings by two pyrazine rings significantly stabilizing the lower oxidation states.	pyridine	232-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
24947336-6	2015	Transport studies using tobacco BY-2 cell lines overexpressing NtNUP1 or PUP1 showed that NtNUP1, similar to PUP1, transported various compounds containing a pyridine ring, but that the two transporters had distinct substrate preferences.	pyridine	158-166	purine permease 1	Arabidopsis thaliana	73-77
24947336-6	2015	Transport studies using tobacco BY-2 cell lines overexpressing NtNUP1 or PUP1 showed that NtNUP1, similar to PUP1, transported various compounds containing a pyridine ring, but that the two transporters had distinct substrate preferences.	pyridine	158-166	purine permease 1	Arabidopsis thaliana	109-113
25752662-0	2015	Lewis acid behavior of SF4 : synthesis, characterization, and computational study of adducts of SF4 with pyridine and pyridine derivatives.	pyridine	105-113	SURP and G-patch domain containing 1	Homo sapiens	23-26
25797273-6	2015	Similar chemical modification on bidentate and arene ligands or other sites of the pyridine ligand may lead to more efficient agents with PDT and/or PACT activities.	pyridine	83-91	RB binding protein 6, ubiquitin ligase	Homo sapiens	149-153
25752662-0	2015	Lewis acid behavior of SF4 : synthesis, characterization, and computational study of adducts of SF4 with pyridine and pyridine derivatives.	pyridine	105-113	SURP and G-patch domain containing 1	Homo sapiens	96-99
25752662-0	2015	Lewis acid behavior of SF4 : synthesis, characterization, and computational study of adducts of SF4 with pyridine and pyridine derivatives.	pyridine	118-126	SURP and G-patch domain containing 1	Homo sapiens	23-26
25752662-0	2015	Lewis acid behavior of SF4 : synthesis, characterization, and computational study of adducts of SF4 with pyridine and pyridine derivatives.	pyridine	118-126	SURP and G-patch domain containing 1	Homo sapiens	96-99
25677452-2	2015	The complexes between SnX2 (where X = H, F, Cl, Br, and I) and benzene or pyridine are considered.	pyridine	74-82	sorting nexin 2	Homo sapiens	22-26
25659771-0	2015	Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.	pyridine	0-8	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	92-97
25659771-1	2015	A series of pyridine derivatives in the C-region of N-((6-trifluoromethyl-pyridin-3-yl)methyl) 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides were investigated as hTRPV1 antagonists.	pyridine	12-20	transient receptor potential cation channel subfamily V member 1	Homo sapiens	169-175
25291712-3	2015	Pyridinium aldoximes have antidotal effects against poisoning with cholinesterase inhibitors, a frequent problem affecting people working with organophosphate-based insecticides and pesticides.	pyridine	0-10	butyrylcholinesterase	Homo sapiens	67-81
25645872-9	2015	The pool sizes of both pyridine and adenylate nucleotides in sta6 increased substantially to compensate for the slower rate of turnover.	pyridine	23-31	uncharacterized protein	Chlamydomonas reinhardtii	61-65
25590985-4	2015	In an effort to understand and improve this behavior, monosubstituted pyridine ligands were used to assess the impact of donor nitrogen basicity on binding strength and stability of fac-[M(I)(CO)3](+) in a 2 + 1 labeling strategy.	pyridine	70-78	FA complementation group C	Homo sapiens	182-185
25267798-7	2014	Glucose-6-phosphate dehydrogenase is a major source of pyridine molecule (nicotinamide adenine dinucleotide phosphate), which is a substrate for nicotinamide adenine dinucleotide phosphate oxidases in the heart.	pyridine	55-63	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-33
25493639-5	2015	Starting from [(2)C3(1)C2Py][NTf2], the lower volatility is governed by the combination of slightly lower entropies and higher enthalpies of vaporization, an indication of a higher structural disorder of the pyridinium based ionic liquids than the imidazolium based ionic liquids.	pyridine	208-218	nuclear transport factor 2	Homo sapiens	29-33
25358895-2	2015	Substitution of the DHP core with electron-withdrawing pyridinium groups was found to have major effects on the photoisomerization efficiency, the most remarkable examples being to enhance the quantum yield of the opening reaction and to allow fast and quantitative conversions at much lower radiant energies.	pyridine	55-65	dihydropyrimidinase	Homo sapiens	20-23
25906044-7	2015	Twenty-five pyridine and pyrimidine derivatives as novel potential BTK inhibitors were finally selected for further study.	pyridine	12-20	Bruton tyrosine kinase	Homo sapiens	67-70
25277835-0	2014	Synthesis and biological evaluation of novel pyridine derivatives as potential anticancer agents and phosphodiesterase-3 inhibitors.	pyridine	45-53	phosphodiesterase 3A	Homo sapiens	101-120
26400662-6	2015	In this paper, we address the evolution of tetracobalt(III) cubanes, stabilised by a pyridine/acetate ligand pool, to active species that perform water oxidation to oxygen.	pyridine	85-93	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	55-58
25453812-1	2014	Herein, we described a new class of uncharged non-pyridinium reactivators for nerve agent-inhibited acetylcholinesterase (AChE).	pyridine	50-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	122-126
25278359-3	2014	The prepared bimetals-dispersed web of ACF/CNF was treated with pyridine and the surface functionalized material was applied for the removal of NO by reduction.	pyridine	64-72	ACF	Homo sapiens	39-42
25278359-3	2014	The prepared bimetals-dispersed web of ACF/CNF was treated with pyridine and the surface functionalized material was applied for the removal of NO by reduction.	pyridine	64-72	NPHS1 adhesion molecule, nephrin	Homo sapiens	43-46
25315319-1	2014	In this study, for distal-selective beta-hydride elimination to produce exomethylene compounds with a newly formed Csp(3)-Csp(3) bond between tertiary alkyl halides and alpha-alkylated styrenes, a combination of a Cu(I) salt and a pyridine-based amine ligand (TPMA) is found to be a very efficient catalyst system.	pyridine	231-239	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	115-118
25414195-2	2014	One component of RPE lipofuscin has been characterized as pdA2E, a pyridinium adduct derived from all-trans-retinal and excess ethanolamine.	pyridine	67-77	ribulose-phosphate 3-epimerase	Bos taurus	17-20
25411889-4	2014	Regarding the mechanism, derivation of the rate law from NMR spectroscopic and kinetic measurements suggests first order in catalyst concentration, fractional order in pyridine concentration and inverse first order in pinacolborane concentration, with C=N insertion into the La-H bond as turnover-determining.	pyridine	168-176	desmoglein 4	Homo sapiens	275-279
25315319-1	2014	In this study, for distal-selective beta-hydride elimination to produce exomethylene compounds with a newly formed Csp(3)-Csp(3) bond between tertiary alkyl halides and alpha-alkylated styrenes, a combination of a Cu(I) salt and a pyridine-based amine ligand (TPMA) is found to be a very efficient catalyst system.	pyridine	231-239	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	122-125
25218671-4	2014	The pyridine ring containing alkylated sulfonium species, dimethyl(pyridin-2-yl)sulfonium (2), reduced the free energy of activation by 4.4kcal/mol compared to the previously reported alkylating agent N-methyl-2-methoxypyridinium species (A) for the alkylation of aged AChE-OP adduct.	pyridine	4-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	269-273
25140352-1	2014	Two fluorescent probes, m-PSP and p-PSP , for sulfite and/or sulfide were constructed by connecting a pyridinium ion to a coumarin fluorophore through an alpha,beta-unsaturated ketone.	pyridine	102-112	microseminoprotein beta	Homo sapiens	26-29
25317482-1	2014	A novel noncentrosymmetric calcium borate, Ca2[B5O9] (OH) H2O (1), was synthesized under solvothermal condition using mixed solvents of pyridine and H2O.	pyridine	136-144	carbonic anhydrase 2	Homo sapiens	43-46
25140352-1	2014	Two fluorescent probes, m-PSP and p-PSP , for sulfite and/or sulfide were constructed by connecting a pyridinium ion to a coumarin fluorophore through an alpha,beta-unsaturated ketone.	pyridine	102-112	microseminoprotein beta	Homo sapiens	36-39
25157565-3	2014	Here, to fill this deficiency, we conducted detailed analyses of the SERS of pyridine adsorbed through N-Ag bonding on the homonuclear diatomic metal cluster Ag2 and heteronuclear diatomic metal clusters of AuAg and CuAg, as well as the involved charge transfer under an intracluster excitation, based on calculations using time-dependent density functional theory with a short-time approximation for the Raman cross-section.	pyridine	77-85	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	158-161
25326649-5	2014	We show that the specificity of Myc-Max PPI reduction by the pyridine inhibitors directly correlates with their efficient and highly specific potential to interfere with the proliferation of human and avian tumor cells displaying deregulated Myc expression.	pyridine	61-69	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	32-35
25326649-5	2014	We show that the specificity of Myc-Max PPI reduction by the pyridine inhibitors directly correlates with their efficient and highly specific potential to interfere with the proliferation of human and avian tumor cells displaying deregulated Myc expression.	pyridine	61-69	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	242-245
25326649-6	2014	In a direct comparison with known Myc inhibitors using human and avian cell systems, the pyridine compounds reveal a unique inhibitory potential even at sub-micromolar concentrations combined with remarkable specificity for the inhibition of Myc-driven tumor cell proliferation.	pyridine	89-97	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	34-37
25326649-6	2014	In a direct comparison with known Myc inhibitors using human and avian cell systems, the pyridine compounds reveal a unique inhibitory potential even at sub-micromolar concentrations combined with remarkable specificity for the inhibition of Myc-driven tumor cell proliferation.	pyridine	89-97	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	242-245
25326649-7	2014	Furthermore, we show in direct comparisons using defined avian cell systems that different Max PPI profiles for the variant members of the Myc protein family (c-Myc, v-Myc, N-Myc, L-Myc) correlate with their diverse oncogenic potential and their variable sensitivity to the novel pyridine inhibitors.	pyridine	280-288	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	139-142
25326649-7	2014	Furthermore, we show in direct comparisons using defined avian cell systems that different Max PPI profiles for the variant members of the Myc protein family (c-Myc, v-Myc, N-Myc, L-Myc) correlate with their diverse oncogenic potential and their variable sensitivity to the novel pyridine inhibitors.	pyridine	280-288	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	159-164
25326649-7	2014	Furthermore, we show in direct comparisons using defined avian cell systems that different Max PPI profiles for the variant members of the Myc protein family (c-Myc, v-Myc, N-Myc, L-Myc) correlate with their diverse oncogenic potential and their variable sensitivity to the novel pyridine inhibitors.	pyridine	280-288	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	161-164
25326649-7	2014	Furthermore, we show in direct comparisons using defined avian cell systems that different Max PPI profiles for the variant members of the Myc protein family (c-Myc, v-Myc, N-Myc, L-Myc) correlate with their diverse oncogenic potential and their variable sensitivity to the novel pyridine inhibitors.	pyridine	280-288	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	173-178
25326649-7	2014	Furthermore, we show in direct comparisons using defined avian cell systems that different Max PPI profiles for the variant members of the Myc protein family (c-Myc, v-Myc, N-Myc, L-Myc) correlate with their diverse oncogenic potential and their variable sensitivity to the novel pyridine inhibitors.	pyridine	280-288	MYCL proto-oncogene, bHLH transcription factor	Homo sapiens	180-185
25116330-6	2014	Following functionalization, reduction of the directing C-2 substituent provides the product arising from formal ortho borylation of an unhindered pyridine ring.	pyridine	147-155	complement C2	Homo sapiens	56-59
25328266-4	2014	In general the introduction of an electron-donating group (e.g., Me, NMe2) at specific positions on the pyridine ring resulted in increased antiproliferative activity, whereas electron-withdrawing groups (e.g., COMe, COOMe, CONEt2) decreased anticancer activity.	pyridine	104-112	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	69-73
25048616-3	2014	The captodative effect of PLP is balanced by an enzyme active site that controls the deprotonation of both the pyridine nitrogen atom (N1) and the Schiff-base nitrogen atom (N2).	pyridine	111-119	pyridoxal phosphatase	Homo sapiens	26-29
25247390-3	2014	Reaction of per-O-silylated Neu5Ac ester with AcOH and Ac2O in pyridine promotes regioselective silyl ether/acetate exchange in the following order: C4 (2 ) &gt; C9 (1 ) &gt; C8 (2 ) &gt; C2 (anomeric).	pyridine	63-71	adenylate cyclase 2	Homo sapiens	55-58
25408831-2	2014	Structure-activity relationship studies revealed that incorporation of a cyclopropane-containing side chain at the 5-position of the pyridine ring provides ligands with improved subtype selectivity for nAChR beta2 subunit-containing nAChR subtypes (beta2*-nAChRs) over beta4*-nAChRs compared to the parent compound 4.	pyridine	133-141	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	202-207
25408831-2	2014	Structure-activity relationship studies revealed that incorporation of a cyclopropane-containing side chain at the 5-position of the pyridine ring provides ligands with improved subtype selectivity for nAChR beta2 subunit-containing nAChR subtypes (beta2*-nAChRs) over beta4*-nAChRs compared to the parent compound 4.	pyridine	133-141	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	233-238
25139613-2	2014	Refluxing Mo(CO)6 with the pyridine-substituted PDI ligand, (PyEt)PDI, resulted in carbonyl ligand substitution and formation of the respective bis(ligand) compound ((PyEt)PDI)2Mo (1).	pyridine	27-35	peptidyl arginine deiminase 1	Homo sapiens	48-51
25139613-2	2014	Refluxing Mo(CO)6 with the pyridine-substituted PDI ligand, (PyEt)PDI, resulted in carbonyl ligand substitution and formation of the respective bis(ligand) compound ((PyEt)PDI)2Mo (1).	pyridine	27-35	peptidyl arginine deiminase 1	Homo sapiens	66-69
25139613-2	2014	Refluxing Mo(CO)6 with the pyridine-substituted PDI ligand, (PyEt)PDI, resulted in carbonyl ligand substitution and formation of the respective bis(ligand) compound ((PyEt)PDI)2Mo (1).	pyridine	27-35	peptidyl arginine deiminase 1	Homo sapiens	66-69
24881047-2	2014	Dsd1p uses the Tyr residue (Y203) to interact with the pyridine nitrogen of PLP, which is a unique feature of PLP enzymes.	pyridine	55-63	D-serine ammonia-lyase DSD1	Saccharomyces cerevisiae S288C	0-5
24878359-9	2014	These findings strongly support our assumption that the fragment of benzamide can replace the pyridine ring in some PI3K and mTOR dual inhibitor to design novel anticancer agents.	pyridine	94-102	mechanistic target of rapamycin kinase	Homo sapiens	125-129
25114221-1	2014	In a fluorescence polarization screen for the MYC-MAX interaction, we have identified a novel small-molecule inhibitor of MYC, KJ-Pyr-9, from a Krohnke pyridine library.	pyridine	152-160	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	46-49
25114221-1	2014	In a fluorescence polarization screen for the MYC-MAX interaction, we have identified a novel small-molecule inhibitor of MYC, KJ-Pyr-9, from a Krohnke pyridine library.	pyridine	152-160	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	122-125
24927393-2	2014	The outstanding structural features of the methoxy derivative 2b in the crystalline state are that (1) two pyridine rings (P1 and P2) of the cyclic trimer of 2b are almost coplanar, and the third pyridine ring (P3) is largely bent away from P1 and P2, and (2) P3 of the cyclic trimer stacks in a face-to-face fashion with one of the pyridine rings (P3") of an adjacent cyclic trimer.	pyridine	107-115	crystallin gamma F, pseudogene	Homo sapiens	123-132
25080249-1	2014	3-(4-Pyridyl)-acetylacetone (HacacPy) acts as a pyridine-type ligand towards CdX2 (X = Cl, Br, I).	pyridine	48-56	caudal type homeobox 2	Homo sapiens	77-81
24939011-1	2014	Heating a benzene solution of [eta(5)-(Me2NCH2CH2)C2B9H10] Ta(NMe2)3 (1) in the presence of pyridine gave an unprecedented complex [eta(1):eta(6)-(Me2NCH2CH2)C2B9H10]Ta (NMe2)(NC5H5) (2).	pyridine	92-100	endothelin receptor type A	Homo sapiens	31-34
24939011-1	2014	Heating a benzene solution of [eta(5)-(Me2NCH2CH2)C2B9H10] Ta(NMe2)3 (1) in the presence of pyridine gave an unprecedented complex [eta(1):eta(6)-(Me2NCH2CH2)C2B9H10]Ta (NMe2)(NC5H5) (2).	pyridine	92-100	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	62-66
24939011-1	2014	Heating a benzene solution of [eta(5)-(Me2NCH2CH2)C2B9H10] Ta(NMe2)3 (1) in the presence of pyridine gave an unprecedented complex [eta(1):eta(6)-(Me2NCH2CH2)C2B9H10]Ta (NMe2)(NC5H5) (2).	pyridine	92-100	endothelin receptor type A	Homo sapiens	132-135
24939011-1	2014	Heating a benzene solution of [eta(5)-(Me2NCH2CH2)C2B9H10] Ta(NMe2)3 (1) in the presence of pyridine gave an unprecedented complex [eta(1):eta(6)-(Me2NCH2CH2)C2B9H10]Ta (NMe2)(NC5H5) (2).	pyridine	92-100	endothelin receptor type A	Homo sapiens	132-135
24939011-1	2014	Heating a benzene solution of [eta(5)-(Me2NCH2CH2)C2B9H10] Ta(NMe2)3 (1) in the presence of pyridine gave an unprecedented complex [eta(1):eta(6)-(Me2NCH2CH2)C2B9H10]Ta (NMe2)(NC5H5) (2).	pyridine	92-100	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	170-174
24746028-0	2014	Two [1,2,4-(Me3C)3C5H2]2CeH molecules are involved in hydrogenation of pyridine to piperidine as shown by experiments and computations.	pyridine	71-79	epoxide hydrolase 2	Homo sapiens	24-27
24507930-4	2014	Each compound can undergo two metal-centered one-electron reductions leading to formation of Co(II) and Co(I) derivatives in CH2Cl2 or pyridine containing 0.1 M tetra-n-butylammonium perchlorate (TBAP).	pyridine	135-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
24507930-4	2014	Each compound can undergo two metal-centered one-electron reductions leading to formation of Co(II) and Co(I) derivatives in CH2Cl2 or pyridine containing 0.1 M tetra-n-butylammonium perchlorate (TBAP).	pyridine	135-143	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	104-109
24777170-1	2014	Rh(III)-catalyzed C-3 selective alkenylation of pyridine derivatives via hydroarylation of alkynes has been developed.	pyridine	48-56	complement C3	Homo sapiens	18-21
24794103-2	2014	To decrease brain exposure and minimize emesis, we modified the lipophilic moiety of a series of emetic PDE4 inhibitors and found that introduction of a hydroxy group into the pyridine moiety of the side chain led to non-emetic compounds with preserved PDE4 inhibitory activity.	pyridine	176-184	phosphodiesterase 4A	Homo sapiens	104-108
24794103-2	2014	To decrease brain exposure and minimize emesis, we modified the lipophilic moiety of a series of emetic PDE4 inhibitors and found that introduction of a hydroxy group into the pyridine moiety of the side chain led to non-emetic compounds with preserved PDE4 inhibitory activity.	pyridine	176-184	phosphodiesterase 4A	Homo sapiens	253-257
24813619-8	2014	The presence of uncoordinated pyridine donor groups in 4 allowed the use of this complex for the preparation of the neutral tetranuclear complex [{Pd(dmba)}2(mu-L){PdCl(dmba)}2] (6) in which 4 acts as a NPy,NPy-bidentate metalloligand toward two PdCl(dmba) moieties.	pyridine	30-38	neuropeptide Y	Homo sapiens	203-206
24813619-8	2014	The presence of uncoordinated pyridine donor groups in 4 allowed the use of this complex for the preparation of the neutral tetranuclear complex [{Pd(dmba)}2(mu-L){PdCl(dmba)}2] (6) in which 4 acts as a NPy,NPy-bidentate metalloligand toward two PdCl(dmba) moieties.	pyridine	30-38	neuropeptide Y	Homo sapiens	207-210
24671330-2	2014	A new class of isoindolin-1-one based BF2 complexes containing pyridine or benzothiazole groups has been prepared from a facile "one-pot" reaction and characterized structurally, spectroscopically and electrochemically.	pyridine	63-71	forkhead box G1	Homo sapiens	38-41
24775307-6	2014	Using proprietary methodology, the high-affinity pyridine or imidazole metal-binding group found in current clinical CYP17 inhibitors was replaced with novel, less avid, metal-binding groups in concert with potency-enhancing molecular scaffold modifications.	pyridine	49-57	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	117-122
24560625-5	2014	The BSA weakly bind to pyridine tethered naphthoquinones, whereas HSA does not binds with them.	pyridine	23-31	albumin	Homo sapiens	4-7
24441022-1	2014	The synthesis and characterization of a pair of novel pyridine cation derivatives possessing two-photon excitation fluorescence (TPEF) properties and selectively staining mitochondria in living SiHa cells within 30 min, CAI and CAEI, were reported.	pyridine	54-62	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	129-133
24462920-7	2014	From computational modeling two potential binding modes for axitinib were identified in the active site of CYP1A2: one in which the oxidizable axitinib thioether sulfur atom is within ~4.45 A of the CYP1A2 heme, and is likely to favor biotransformation of the drug, and a second in which the pyridine moiety is in proximity to the heme, which may contribute to inhibition.	pyridine	292-300	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	107-113
24481140-3	2014	Reaction of in situ-generated [Ru(eta(5)-C5H5)(py)3](+) (py = pyridine) with PPh3 results in the formation of [Ru(eta(5)-C5H5)(PPh3)(py)2](+), the active catalyst for direct alkenylation, some [Ru(eta(5)-C5H5)(PPh3)2(py)](+) is also formed in this reaction.	pyridine	62-70	protein phosphatase 4 catalytic subunit	Homo sapiens	77-81
24481140-3	2014	Reaction of in situ-generated [Ru(eta(5)-C5H5)(py)3](+) (py = pyridine) with PPh3 results in the formation of [Ru(eta(5)-C5H5)(PPh3)(py)2](+), the active catalyst for direct alkenylation, some [Ru(eta(5)-C5H5)(PPh3)2(py)](+) is also formed in this reaction.	pyridine	62-70	protein phosphatase 4 catalytic subunit	Homo sapiens	127-131
24481140-3	2014	Reaction of in situ-generated [Ru(eta(5)-C5H5)(py)3](+) (py = pyridine) with PPh3 results in the formation of [Ru(eta(5)-C5H5)(PPh3)(py)2](+), the active catalyst for direct alkenylation, some [Ru(eta(5)-C5H5)(PPh3)2(py)](+) is also formed in this reaction.	pyridine	62-70	protein phosphatase 4 catalytic subunit	Homo sapiens	127-131
24692049-4	2014	In the particular combination of two different types of pyridine ligand in the cationic fac-Re(CO)3 complexes only the cross-coupling products with asymmetric 2,2"-bipyridine ligands were obtained; the homocoupling products were not observed.	pyridine	56-64	FA complementation group C	Homo sapiens	88-91
24940191-2	2014	The Ni-N bond lengths to the pyridine rings are 2.1189 (17) and 2.1241 (17) A, whereas those to the thiocyanate anions are 2.0299 (18) and 2.0359 A.	pyridine	29-37	ninein	Homo sapiens	4-8
24669888-1	2014	A series of novel pyridine-bridged analogues of combretastatin-A4 (CA-4) were designed and synthesized.	pyridine	18-26	carbonic anhydrase 4	Mus musculus	67-71
24599312-2	2014	These compounds show an ability to reactivate VX-inhibited BChE largely superior to those of known pyridinium aldoximes.	pyridine	99-109	butyrylcholinesterase	Homo sapiens	59-63
24631364-2	2014	The combined MD simulations and QM/MM-PBSA calculations reveal that the most important structural parameters affecting the CYP2A6-inhibitor binding affinity are two crucial internuclear distances, that is, the distance between the heme iron atom of CYP2A6 and the coordinating atom of the inhibitor, and the hydrogen-bonding distance between the N297 side chain of CYP2A6 and the pyridine nitrogen of the inhibitor.	pyridine	380-388	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	123-129
24631364-2	2014	The combined MD simulations and QM/MM-PBSA calculations reveal that the most important structural parameters affecting the CYP2A6-inhibitor binding affinity are two crucial internuclear distances, that is, the distance between the heme iron atom of CYP2A6 and the coordinating atom of the inhibitor, and the hydrogen-bonding distance between the N297 side chain of CYP2A6 and the pyridine nitrogen of the inhibitor.	pyridine	380-388	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	249-255
24631364-2	2014	The combined MD simulations and QM/MM-PBSA calculations reveal that the most important structural parameters affecting the CYP2A6-inhibitor binding affinity are two crucial internuclear distances, that is, the distance between the heme iron atom of CYP2A6 and the coordinating atom of the inhibitor, and the hydrogen-bonding distance between the N297 side chain of CYP2A6 and the pyridine nitrogen of the inhibitor.	pyridine	380-388	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	249-255
24594722-4	2014	Each 2,5-PDC(2-) anion chelates to one Co(II) cation via the pyridine N atom and an O atom of the adjacent carboxylate group, and links to two other Co(II) cations in a bridging mode via the O atoms of the other carboxylate group.	pyridine	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
24333504-12	2014	Further, the possible mechanism of pyridine-induced pharyngitis is thought to be primarily mediated through phospholipase A2 and cyclooxygenase (COX) pathway.	pyridine	35-43	phospholipase A2 group IB	Rattus norvegicus	108-124
24448391-7	2014	Both pyridine derivatives induced thermogenesis, although trigonelline presumably promoted proton leaks, while NMP increased the concentration of the uncoupling protein-2.	pyridine	5-13	uncoupling protein 2	Homo sapiens	150-170
24300990-11	2014	However, additions of 1-methylimidazole, pyridine and pyrazine as axial ligands result in the formation of a six-coordinate complex in which Co(II) is spontaneously oxidized to Co(III) in air.	pyridine	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
24402735-5	2014	Solution studies revealed an unanticipated solvent-dependent equilibrium between the anti-anti and syn-syn conformations of the pyrrole ring with respect to its two adjacent pyridine units.	pyridine	174-182	synemin	Homo sapiens	99-102
24402735-5	2014	Solution studies revealed an unanticipated solvent-dependent equilibrium between the anti-anti and syn-syn conformations of the pyrrole ring with respect to its two adjacent pyridine units.	pyridine	174-182	synemin	Homo sapiens	103-106
24531493-3	2014	In the structures, the dihedral angle between the pyridine ring and the Schiff-base linkage of PLP varied from 18  to 52 .	pyridine	50-58	pyridoxal phosphatase	Homo sapiens	95-98
24346623-0	2014	Weak C-H   N and C-H   F hydrogen bonds and internal rotation in pyridine-CH3F.	pyridine	65-73	nuclear receptor subfamily 4 group A member 3	Homo sapiens	5-20
24170306-1	2014	Studies examining the photochemical reactivity of CpRu(PPh3)2Cl and CpRu(PPh3)2Me towards the two electron donor ligands PEt3, C2H4, DMSO, the CH bond activatable reagents tetrahydrofuran, toluene, and pyridine, and the SiH bond activatable reagents HSiEt3 and HSi(Me)2CH=CH2) are presented.	pyridine	202-210	protein phosphatase 4 catalytic subunit	Homo sapiens	55-59
24355692-2	2014	In the catalytic process of PLP-dependent enzymes, the substrate amino acid forms a Schiff base with PLP and the electrophilicity of the PLP pyridine ring plays important roles in the subsequent catalytic steps.	pyridine	141-149	pyridoxal phosphatase	Homo sapiens	28-31
24355692-2	2014	In the catalytic process of PLP-dependent enzymes, the substrate amino acid forms a Schiff base with PLP and the electrophilicity of the PLP pyridine ring plays important roles in the subsequent catalytic steps.	pyridine	141-149	pyridoxal phosphatase	Homo sapiens	101-104
24355692-2	2014	In the catalytic process of PLP-dependent enzymes, the substrate amino acid forms a Schiff base with PLP and the electrophilicity of the PLP pyridine ring plays important roles in the subsequent catalytic steps.	pyridine	141-149	pyridoxal phosphatase	Homo sapiens	101-104
24170306-1	2014	Studies examining the photochemical reactivity of CpRu(PPh3)2Cl and CpRu(PPh3)2Me towards the two electron donor ligands PEt3, C2H4, DMSO, the CH bond activatable reagents tetrahydrofuran, toluene, and pyridine, and the SiH bond activatable reagents HSiEt3 and HSi(Me)2CH=CH2) are presented.	pyridine	202-210	protein phosphatase 4 catalytic subunit	Homo sapiens	73-77
24552059-5	2013	The degradation kinetics of pyridine follows first-order kinetics and k = 5.53 x 10(-3) min-1.	pyridine	28-36	CD59 molecule (CD59 blood group)	Homo sapiens	88-93
23835215-1	2013	Fluorescent imaging of acidic compartments in living cells was carried out successfully by a novel molecule (CAE) that contained a pyridine unit and a carbazole core.	pyridine	131-139	gap junction protein alpha 8	Homo sapiens	109-112
24195762-0	2013	Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors.	pyridine	77-85	MER proto-oncogene, tyrosine kinase	Homo sapiens	117-120
24215616-3	2013	They react with acetonitrile and pyridine to produce [Ir(H)2(NCMe)(py)(IMes)(PPh3)]BF4 and [Ir(H)2(NCMe)(py)(IMes)(PCy3)]BF4, complexes that undergo ligand exchange on a time scale commensurate with observation of the SABRE effect, which is illustrated here by the observation of both pyridine and acetonitrile HP.	pyridine	33-41	protein phosphatase 4 catalytic subunit	Homo sapiens	77-81
24215616-3	2013	They react with acetonitrile and pyridine to produce [Ir(H)2(NCMe)(py)(IMes)(PPh3)]BF4 and [Ir(H)2(NCMe)(py)(IMes)(PCy3)]BF4, complexes that undergo ligand exchange on a time scale commensurate with observation of the SABRE effect, which is illustrated here by the observation of both pyridine and acetonitrile HP.	pyridine	285-293	protein phosphatase 4 catalytic subunit	Homo sapiens	77-81
24108309-1	2013	Electrochemical SERS (E-SERS) was used for the first time to study the interfacial behavior of a class of pyridinium-based biodegradable ionic liquids at a silver nanoparticle (AgNP) electrode surface.	pyridine	106-116	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	16-20
24108309-1	2013	Electrochemical SERS (E-SERS) was used for the first time to study the interfacial behavior of a class of pyridinium-based biodegradable ionic liquids at a silver nanoparticle (AgNP) electrode surface.	pyridine	106-116	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	24-28
24205994-1	2013	In this work is investigated why the entrance of a nitrogen atom in the ring of cis-2-hydroxypyridine and 2-pyridinone, resulting in cis-4-hydroxypyrimidine and 4(3H)-pyrimidinone, respectively, shifts the tautomeric equilibrium from the hydroxyl form, in the pyridine derivative, to the ketonic form, in the pyrimidine derivative.	pyridine	93-101	suppressor of cytokine signaling 2	Homo sapiens	80-85
24205994-1	2013	In this work is investigated why the entrance of a nitrogen atom in the ring of cis-2-hydroxypyridine and 2-pyridinone, resulting in cis-4-hydroxypyrimidine and 4(3H)-pyrimidinone, respectively, shifts the tautomeric equilibrium from the hydroxyl form, in the pyridine derivative, to the ketonic form, in the pyrimidine derivative.	pyridine	93-101	suppressor of cytokine signaling 6	Homo sapiens	133-138
24241081-1	2013	5-Hydroxy-2-pyridone (2,5-DHP) is a central metabolic intermediate in catabolism of many pyridine derivatives, and has been suggested as a potential carcinogen.	pyridine	89-97	dihydropyrimidinase	Homo sapiens	26-29
24047900-0	2013	Complexes of Trypanosoma cruzi sterol 14alpha-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.	pyridine	75-83	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	59-64
24047900-6	2013	Comparative analysis of the pyridine- and azole-bound CYP51 structures uncovered the features that make UDO and UDD T. cruzi CYP51-specific.	pyridine	28-36	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	54-59
24047900-6	2013	Comparative analysis of the pyridine- and azole-bound CYP51 structures uncovered the features that make UDO and UDD T. cruzi CYP51-specific.	pyridine	28-36	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	125-130
24047900-7	2013	The structures suggest that although a precise fit between the shape of the inhibitor molecules and T. cruzi CYP51 active site topology underlies their high inhibitory potency, a longer coordination bond between the catalytic heme iron and the pyridine nitrogen implies a weaker influence of pyridines on the iron reduction potential, which may be the basis for the observed selectivity of these compounds toward the target enzyme versus other cytochrome P450s, including human drug-metabolizing P450s.	pyridine	244-252	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	109-114
24367923-5	2014	As a typical example for these pyridine based S1P1 agonists, compound 53 showed EC50 values of 0.6 and 352 nM for the S1P1 and S1P3 receptor, respectively, displayed favorable PK properties, and penetrated well into brain tissue.	pyridine	31-39	sphingosine-1-phosphate receptor 1	Rattus norvegicus	46-50
25671173-5	2014	Linear-dendritic copolymer was prepared in the presence of DCC in pyridine.	pyridine	66-74	DCC netrin 1 receptor	Homo sapiens	59-62
24328274-3	2013	Such extraordinary stability hampers the individual binding of either carboxylic acid ligands through the amidine group or pyridine-type ligands through the Zn(II) metal atom to (Pc1)2.	pyridine	123-131	polycystin 1, transient receptor potential channel interacting	Homo sapiens	179-182
24220173-0	2013	Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.	pyridine	60-70	butyrylcholinesterase	Homo sapiens	128-142
24093603-1	2013	The reaction of Morita-Baylis-Hillman (MBH) alcohols with Me2PhSiBpin under the catalysis of Cu(OTf)2/pyridine in methanol has been developed.	pyridine	102-110	POU class 2 homeobox 2	Homo sapiens	93-101
23987415-3	2013	Pyridine-soluble beta-1,3-glucan formate was first synthesized as an intermediate and then reacted with various anhydrates to yield beta-1,3-glucan acetate and hexaonate.	pyridine	0-8	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	17-25
23987415-3	2013	Pyridine-soluble beta-1,3-glucan formate was first synthesized as an intermediate and then reacted with various anhydrates to yield beta-1,3-glucan acetate and hexaonate.	pyridine	0-8	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	132-140
23939290-1	2013	A new building block for low band-gap polymers, diketopyrrolopyrrole (DPP) flanked by pyridine (PyDPP), has been synthesized via a simple synthetic route.	pyridine	86-94	dentin sialophosphoprotein	Homo sapiens	70-73
23785176-7	2013	MATE1 displayed a higher affinity for the pyridinium-based NBuPy (IC50 values, 2-4 microM) than for either the pyrrolidinium- (BmPy; 20-70 microM) or imidazolium-based ILs (Bmim; 15-60 microM).	pyridine	42-52	solute carrier family 47 member 1	Homo sapiens	0-5
24526931-1	2013	In the title compound, [Co(C12H12O4)(C5H5N)2] n , the Co(II) cation is coordinated by four O atoms from three 5-tert-butyl-benzene-1,3-di-carboxyl-ate anions and two N atoms from pyridine mol-ecules in a distorted octa-hedral geometry.	pyridine	179-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
23881771-0	2013	Pyridine-directed palladium-catalyzed phosphonation of C(sp2)-H bonds.	pyridine	0-8	Sp2 transcription factor	Homo sapiens	55-60
23860746-1	2013	We describe the synthesis, characterization and photophysical properties of the dyads Zn2DEP TNF (1) and Zn2DEP 2Py-BDP (2) and triad Zn2DEP 2Py-BDP TNF (3), which enable us to investigate the changes in the spectroscopic properties upon the axial coordination of pyridine substituted bodipy (Py-BDP) to Zn2DEP in the dyads and the further encapsulation of TNF in the triad.	pyridine	264-272	tumor necrosis factor	Homo sapiens	93-96
23860746-1	2013	We describe the synthesis, characterization and photophysical properties of the dyads Zn2DEP TNF (1) and Zn2DEP 2Py-BDP (2) and triad Zn2DEP 2Py-BDP TNF (3), which enable us to investigate the changes in the spectroscopic properties upon the axial coordination of pyridine substituted bodipy (Py-BDP) to Zn2DEP in the dyads and the further encapsulation of TNF in the triad.	pyridine	264-272	tumor necrosis factor	Homo sapiens	149-152
23860746-1	2013	We describe the synthesis, characterization and photophysical properties of the dyads Zn2DEP TNF (1) and Zn2DEP 2Py-BDP (2) and triad Zn2DEP 2Py-BDP TNF (3), which enable us to investigate the changes in the spectroscopic properties upon the axial coordination of pyridine substituted bodipy (Py-BDP) to Zn2DEP in the dyads and the further encapsulation of TNF in the triad.	pyridine	264-272	tumor necrosis factor	Homo sapiens	149-152
23589421-4	2013	Although the overall conformation of the variant is similar to that of normal AGT, we noticed: (i) a displacement of the PLP-binding Lys209 and Val185, located on the re and si side of PLP, respectively, and (ii) slight conformational changes of other active site residues, in particular Trp108, the base stacking residue with the pyridine cofactor moiety.	pyridine	331-339	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	78-81
24427011-1	2013	In the title compound, [Pb(C20H26O2PS2)2(C5H5N)2], the Pb(II) ion is coordinated by two S,S"-bidentate anions and two pyridine mol-ecules.	pyridine	118-126	submaxillary gland androgen regulated protein 3B	Homo sapiens	55-61
23862181-2	2013	We have measured the signal enhancement of pyridine and its exchange rate in various [Ir(NHC)(Py)3(H)2](+) complexes to gain insight into their dependence on the N-Heterocyclic Carbene (NHC) ligand"s steric and electronic properties.	pyridine	43-51	high mobility group nucleosomal binding domain 4	Homo sapiens	89-92
23862181-2	2013	We have measured the signal enhancement of pyridine and its exchange rate in various [Ir(NHC)(Py)3(H)2](+) complexes to gain insight into their dependence on the N-Heterocyclic Carbene (NHC) ligand"s steric and electronic properties.	pyridine	43-51	high mobility group nucleosomal binding domain 4	Homo sapiens	186-189
23589421-4	2013	Although the overall conformation of the variant is similar to that of normal AGT, we noticed: (i) a displacement of the PLP-binding Lys209 and Val185, located on the re and si side of PLP, respectively, and (ii) slight conformational changes of other active site residues, in particular Trp108, the base stacking residue with the pyridine cofactor moiety.	pyridine	331-339	pyridoxal phosphatase	Homo sapiens	121-124
23504218-1	2013	An oxadiazole derivative(OXD) containing symmetrical pyridine-2-formamidophenyl-binded moiety was synthesised as fluorescence turn-on sensor OA1.	pyridine	53-61	OA1	Homo sapiens	141-144
23819458-0	2013	Electrochemistry, surface plasmon resonance, and quartz crystal microbalance: an associative study on cytochrome c adsorption on pyridine tail-group monolayers on gold.	pyridine	129-137	cytochrome c, somatic	Homo sapiens	102-114
23758139-1	2013	Myoglobin reconstituted with oxidized Co(III) deuteroheme was found to exhibit relatively large affinities to CN(-), N3(-), SCN(-), pyridine, and imidazole contrary to the early proposal.	pyridine	132-140	myoglobin	Homo sapiens	0-9
23758139-1	2013	Myoglobin reconstituted with oxidized Co(III) deuteroheme was found to exhibit relatively large affinities to CN(-), N3(-), SCN(-), pyridine, and imidazole contrary to the early proposal.	pyridine	132-140	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	38-45
23685943-5	2013	Docking analysis of 53S using our hTRPV1 homology model indicated that the A- and B-region 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamide made important hydrophobic and hydrogen bonding interactions with Tyr511 and that the C-region 6-trifluoromethyl and 2-benzyloxy groups of pyridine occupied the two hydrophobic binding pockets, respectively.	pyridine	282-290	transient receptor potential cation channel subfamily V member 1	Homo sapiens	34-40
23485401-0	2013	Orally bioavailable and brain-penetrant pyridazine and pyridine-derived gamma-secretase modulators reduced amyloidogenic Abeta peptides in vivo.	pyridine	55-63	amyloid beta precursor protein	Rattus norvegicus	121-126
23485401-7	2013	Here, we report in vivo Abeta-lowering profiles of a pyridazine and a pyridine-derived GSM: GSM-C (Wan et al., 2011a) and GSM-D (Wan et al., 2011b).	pyridine	70-78	amyloid beta precursor protein	Rattus norvegicus	24-29
23697626-1	2013	We recently described the medicinal chemistry of a new series of heteroaryl-4-oxopyridine/7-oxopyrimidines as CB2 receptor partial agonists, showing that the functionality of these ligands is controlled by the nature of the heteroaryl function condensed with the pyridine ring.	pyridine	81-89	cannabinoid receptor 2	Homo sapiens	110-113
23632736-4	2013	The structure of eta(6):kappa(1)-phenylalanine complex 17 and an N-kappa(1)-phenylalanine complex 13 resulting from the reaction of 3 with an excess of pyridine were confirmed by X-ray crystallography.	pyridine	152-160	endothelin receptor type A	Homo sapiens	17-20
23390982-2	2013	It represented a highly efficient and selective C-H bond functionalization of pyridine derivatives in the presence of reactive C-Cl or C-Br bonds.	pyridine	78-86	cannabinoid receptor 1	Homo sapiens	135-139
23230571-1	2013	Reduction of Cp*2UI(THF) with KC8 in the presence of a pyridine(diimine) ligand ((Mes)PDI(Me)) results in the formation of Cp*U(PDI)(THF), which features a triply reduced PDI ligand.	pyridine	55-63	prolyl 4-hydroxylase subunit beta	Homo sapiens	86-89
23586711-0	2013	Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir.	pyridine	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-86
23586711-3	2013	We investigated the mechanism of CYP3A4 interaction with three desoxyritonavir analogues, containing the heme-ligating imidazole, oxazole, or pyridine group instead of the thiazole moiety (compounds 1, 2, and 3, respectively).	pyridine	142-150	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	33-39
23487183-2	2013	In contrast to this, the syn and the anti isomers of a calix[4]pyrrole molecule containing pyridine moieties at the meso positions were isolated and their structures were determined by single crystal X-ray diffraction studies.	pyridine	91-99	synemin	Homo sapiens	25-28
23723870-6	2013	The pyridine ring has a pseudo-axial orientation with respect to the 1,4-DHP ring.	pyridine	4-12	dihydropyrimidinase	Homo sapiens	73-76
23564771-0	2013	Effects of pyridine analogs of curcumin on growth, apoptosis and NF-kappaB activity in prostate cancer PC-3 cells.	pyridine	11-19	nuclear factor kappa B subunit 1	Homo sapiens	65-74
23564771-4	2013	Only pyridine analogs of curcumin with a tetrahydrothiopyrane-4-one linker (FN compounds) exhibited a strong inhibitory effect on growth and a strong stimulatory effect on apoptosis at low concentrations (&lt;= 1 muM).	pyridine	5-13	latexin	Homo sapiens	213-216
23230571-1	2013	Reduction of Cp*2UI(THF) with KC8 in the presence of a pyridine(diimine) ligand ((Mes)PDI(Me)) results in the formation of Cp*U(PDI)(THF), which features a triply reduced PDI ligand.	pyridine	55-63	prolyl 4-hydroxylase subunit beta	Homo sapiens	128-131
23230571-1	2013	Reduction of Cp*2UI(THF) with KC8 in the presence of a pyridine(diimine) ligand ((Mes)PDI(Me)) results in the formation of Cp*U(PDI)(THF), which features a triply reduced PDI ligand.	pyridine	55-63	prolyl 4-hydroxylase subunit beta	Homo sapiens	128-131
23658734-3	2013	Recently, a novel class of compounds, 1,8-naphthyridine, pyridine and quinoline derivatives have been demonstrated to show high CB2 receptor selectivity and affinity versus the CB1 receptor.	pyridine	57-65	cannabinoid receptor 2	Homo sapiens	128-131
23658734-3	2013	Recently, a novel class of compounds, 1,8-naphthyridine, pyridine and quinoline derivatives have been demonstrated to show high CB2 receptor selectivity and affinity versus the CB1 receptor.	pyridine	57-65	cannabinoid receptor 1	Homo sapiens	177-180
23473309-5	2013	Structural modifications of the pyridine moiety, side chain, and peripheral aromatic moieties were evaluated, thereby revealing approaches for reducing hERG binding affinity.	pyridine	32-40	ETS transcription factor ERG	Homo sapiens	152-156
23473309-6	2013	In particular, we found that the extra rigidity imposed close to the positively charged pyridine moiety can be very efficient in decreasing hERG affinity.	pyridine	88-96	ETS transcription factor ERG	Homo sapiens	140-144
23547990-2	2013	A huge amount of data, accumulated over the years, have provided solid evidence that two pyridinium-ring-containing amino acid isoforms, desmosine and isodesmosine (usually referred to as desmosines), unique to mature elastin in humans, are representative of the elastin breakdown occurring in chronic destructive disorders, such as COPD.	pyridine	89-99	elastin	Homo sapiens	218-225
23634005-1	2013	In the title compound, [Co(C7H4ClO2)2(C5H5N)2(H2O)], the Co(II) atom is six-coordinated by three O atoms from a bidentate and a monodentate 4-chloro-benzoate ligand, two N atoms from two pyridine ligands and a water O atom, giving a distorted octa-hedral geometry.	pyridine	187-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
23634088-1	2013	In the title salt, C17H19N4 (+) PF6 (-), the two pyridine rings of the cation are inclined to one another by 15.89 (8) , and inclined to the imidazole ring by 65.05 (10) and 64.07 (10) .	pyridine	49-57	sperm associated antigen 17	Homo sapiens	32-35
23390982-4	2013	Various pyridine compounds can be prepared as illustrated in the total syntheses of Onychine, dielsine, and PARP-1 inhibitor GPI 16539.	pyridine	8-16	poly(ADP-ribose) polymerase 1	Homo sapiens	108-114
23281044-5	2013	Tetracyclic BePI derivatives are characterized by a particular curved shape, and the presence of an oxo group on the pyridine ring was found to be required for aurora kinase B inhibition.	pyridine	117-125	aurora kinase B	Homo sapiens	160-175
23274253-1	2013	The chelating behavior of ligands based on carbohydrazone core modified with pyridine end towards Co(II), Ni(II) and Cu(II) ions have been examined.	pyridine	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
23445881-13	2013	CONCLUSIONS: In this study, we presented a new series of benzofuranone-based derivatives having pyridinium moiety as potent dual acting Acetylcholinesterase/Butyrylcholinesterase inhibitors.	pyridine	96-106	acetylcholinesterase (Cartwright blood group)	Homo sapiens	136-156
23202443-0	2013	Asymmetric cyclopropanation of olefins catalysed by Cu(I) complexes of chiral pyridine-containing macrocyclic ligands (Pc-L*).	pyridine	78-86	PHD finger protein 1	Homo sapiens	119-124
23202443-1	2013	The synthesis and characterisation of copper(I) complexes of chiral pyridine-containing macrocyclic ligands (Pc-L*) and their use as catalysts in asymmetric cyclopropanation reactions are reported.	pyridine	68-76	PHD finger protein 1	Homo sapiens	109-114
23231091-5	2013	(2)H- and (31)P-electron nuclear double resonance studies, supported by computations, show that the position for hydrogen atom abstraction from 2,5-DAPn and 2,4-DAB by the 5"-deoxyadenosyl radical occurs at the carbon adjacent to the imine, resulting in overstabilized radicals by spin delocalization through the imine into the pyridine ring of PLP.	pyridine	328-336	pyridoxal phosphatase	Homo sapiens	345-348
22940872-1	2013	Density functional theory (DFT) calculations at B3LYP/6-31 G (d,p) and B3LYP/6-311+G(d,p) levels for the substituted pyridine-catalyzed isomerization of monomethyl maleate revealed that isomerization proceeds via four steps, with the rate-limiting step being proton transfer from the substituted pyridinium ion to the C=C double bond in INT1.	pyridine	117-125	Wnt family member 1	Homo sapiens	337-341
23253443-0	2013	Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression.	pyridine	60-68	tachykinin receptor 1	Homo sapiens	91-94
23253443-0	2013	Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression.	pyridine	60-68	solute carrier family 6 member 4	Homo sapiens	110-114
24058724-2	2013	We report here novel and metabolically stable analogs that we derived from TRH by replacing its amino-terminal pyroglutamyl (pGlu) residue with pyridinium-containing moieties.	pyridine	144-154	thyrotropin releasing hormone	Mus musculus	75-78
23148598-1	2012	Pyridinium and bis-pyridinium aldoximes are used as antidotes to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents.	pyridine	0-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-96
23148598-1	2012	Pyridinium and bis-pyridinium aldoximes are used as antidotes to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents.	pyridine	0-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	98-102
22935998-1	2012	A multi-functional MOF  was constructed from Cu paddlewheel motifs and a judiciously designed novel ligand bearing carboxylate, pyridine, and amide groups.	pyridine	128-136	lysine acetyltransferase 8	Homo sapiens	19-22
23093113-4	2012	Based on high level coupled-cluster (estimated CCSD(T)/CBS) computations it was concluded that benzene is more aromatic/stable than pyridine by 2.2 kcal mol(-1).	pyridine	132-140	cystathionine beta-synthase	Homo sapiens	55-58
23153015-2	2012	The complexes were prepared in high yield (86%) by direct addition at room temperature of the corresponding pyridine to the tetrahydrofuran (THF) adduct fac-[Re(bpy)(CO)(3)(THF)][PF(6)] precursor.	pyridine	108-116	sperm associated antigen 17	Homo sapiens	179-184
23065958-0	2012	Quaternary chiral beta(2,2)-amino acids with pyridinium and imidazolium substituents.	pyridine	45-55	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	18-26
23136724-0	2012	The history of cholinesterase reactivation: hydroxylamine and pyridinium aldoximes.	pyridine	62-72	butyrylcholinesterase	Homo sapiens	15-29
24052847-0	2012	An Efficient Protocol for the Green and Solvent-Free Synthesis of Azine Derivatives at Room Temperature Using BiCl3-Loaded Montmorillonite K10 as a New Recyclable Heterogeneous Catalyst.	pyridine	66-71	keratin 10	Homo sapiens	139-142
24052847-2	2012	BiCl3 loaded K10 (BiCl3-K10) has been used as solid acid catalyst for the synthesis of azine derivatives from benzophenone hydrazone and ketones/aldehydes by simple physical grinding.	pyridine	87-92	keratin 10	Homo sapiens	13-16
24052847-2	2012	BiCl3 loaded K10 (BiCl3-K10) has been used as solid acid catalyst for the synthesis of azine derivatives from benzophenone hydrazone and ketones/aldehydes by simple physical grinding.	pyridine	87-92	keratin 10	Homo sapiens	24-27
22612279-2	2012	In this work, four pyridine-containing aza-macrocyclic copper(II) complexes were prepared (CuL1-CuL4) varying in ring size and/or substituents and their superoxide scavenging activity evaluated.	pyridine	19-27	cullin 1	Homo sapiens	91-95
22917263-4	2012	The robust association manifests in packing equivalence in all of the inclusion compounds of TP2 with the exception of the compound formed with pyridine and o-dichlorobenzene guests; in the latter, pyridine terminates the otherwise 3-dimensional hydrogen-bonded organization.	pyridine	198-206	transition protein 2	Homo sapiens	93-96
22954468-5	2012	Spectro-electrochemical measurements showed that pyridine coordination resulted in a ~200 mV negative shift in the Co(II/I) reduction potential, E (Co(II/I)/TiO(2)) = -0.72 V and E (Co(II/I)(py)/TiO(2)) = -0.85 V vs NHE.	pyridine	49-57	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	115-122
22954468-5	2012	Spectro-electrochemical measurements showed that pyridine coordination resulted in a ~200 mV negative shift in the Co(II/I) reduction potential, E (Co(II/I)/TiO(2)) = -0.72 V and E (Co(II/I)(py)/TiO(2)) = -0.85 V vs NHE.	pyridine	49-57	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	148-155
22954468-5	2012	Spectro-electrochemical measurements showed that pyridine coordination resulted in a ~200 mV negative shift in the Co(II/I) reduction potential, E (Co(II/I)/TiO(2)) = -0.72 V and E (Co(II/I)(py)/TiO(2)) = -0.85 V vs NHE.	pyridine	49-57	solute carrier family 9 member C1	Homo sapiens	216-219
22632602-0	2012	A resonance Raman enhancement mechanism for axial vibrational modes in the pyridine adduct of myoglobin proximal cavity mutant (H93G).	pyridine	75-83	myoglobin	Homo sapiens	94-103
22901310-3	2012	Anibamine, a novel pyridine quaternary alkaloid isolated from Aniba sp., was found to effectively compete with (125)I-gp120 in binding to the chemokine receptor CCR5, with an IC(50) = 1 muM.	pyridine	19-27	C-C motif chemokine receptor 5	Homo sapiens	161-165
23073222-7	2012	MIFs calculated with the N1 (pyridinium nitrogen) and the DRY GRID probes in the AChE active site enabled us to establish the relationship between amino acid residues within AChE active site and the variables having high impact on models.	pyridine	29-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	81-85
23073222-7	2012	MIFs calculated with the N1 (pyridinium nitrogen) and the DRY GRID probes in the AChE active site enabled us to establish the relationship between amino acid residues within AChE active site and the variables having high impact on models.	pyridine	29-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	174-178
22038178-4	2012	Studies on W101F, W101H and W101A mutants show that only the indole ring of the conserved Trp101 forms most favorable stacking interaction with the pyridine ring of the cofactor PLP.	pyridine	148-156	proteolipid protein 1	Homo sapiens	178-181
22735623-2	2012	Subsequent reaction of 1 and 3 with one equivalent of pyridine at room temperature give RuCl(2)(PPh(3))(py)(C(6)H(4)(PR(2))C(Ph)NH) (R = Ph 4, Me 5).	pyridine	54-62	FAT atypical cadherin 1	Homo sapiens	143-147
22757756-3	2012	Structural and spectroscopic investigations on [RuCl(NO)py(4)](PF(6))(2) 1/2H(2)O (py = pyridine) reveal a nearly 100% conversion from GS to MS1.	pyridine	56-58	MS	Homo sapiens	141-144
22429470-0	2012	Calcitonin gene-related peptide (CGRP) receptor antagonists: pyridine as a replacement for a core amide group.	pyridine	61-69	calcitonin related polypeptide alpha	Homo sapiens	0-31
22803330-5	2012	It has been found that in the crystal structure Asp271 interacts with the pyridine nitrogen atom of PLP through H-bonding in both native and substrate-bound DDC.	pyridine	74-82	pyridoxal phosphatase	Homo sapiens	100-103
22803330-7	2012	In the ligand-free enzyme, the distance between the oxygen atom of 3-OH group of PLP pyridine ring and oxygen atom of Thr246 hydroxyl group is not favorable for hydrogen bonding.	pyridine	85-93	pyridoxal phosphatase	Homo sapiens	81-84
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	pyridine	300-308	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22414965-7	2012	Treatment of the pyridine complex with TlCp results in the formation of a four coordinate anionic cyclopentadienyl complex.	pyridine	17-25	lipocalin 1	Homo sapiens	39-43
22590223-1	2012	In the title salt, C(12)H(10)NO(2) (+) NO(3) (-), the dihedral angle between the pyridine ring and the benzene ring of the 4-(3-carb-oxy-phen-yl)pyridinium cation is 30.14 (2) .	pyridine	81-89	syntaxin 8	Homo sapiens	128-132
22400713-3	2012	We found that the hydrazide linker and the 3,5-disubstituted chlorides in the pyridine skeleton were critical for P2X(7) antagonistic activity and that the presence of hydrophobic polycycloalkyl groups at the R(2) position optimized antagonistic activity.	pyridine	78-86	purinergic receptor P2X 7	Homo sapiens	114-120
22429470-0	2012	Calcitonin gene-related peptide (CGRP) receptor antagonists: pyridine as a replacement for a core amide group.	pyridine	61-69	calcitonin related polypeptide alpha	Homo sapiens	33-37
22429470-1	2012	In our continuing efforts to identify CGRP receptor antagonists that can be dosed orally for the treatment of migraine headache, we have investigated a pyridine bioisosteric replacement of a polar amide portion of a previous lead compound, BMS-694153.	pyridine	152-160	calcitonin related polypeptide alpha	Homo sapiens	38-42
22311067-1	2012	Photoinduced electron-transfer dynamics of self-assembled donor-acceptor dyads formed by axial coordination of zinc naphthalocyanine, ZnNc, and perylenediimide (PDI) bearing either pyridine (py) or imidazole (im) coordinating ligands were investigated.	pyridine	181-189	peptidyl arginine deiminase 1	Homo sapiens	161-164
22311067-1	2012	Photoinduced electron-transfer dynamics of self-assembled donor-acceptor dyads formed by axial coordination of zinc naphthalocyanine, ZnNc, and perylenediimide (PDI) bearing either pyridine (py) or imidazole (im) coordinating ligands were investigated.	pyridine	181-183	peptidyl arginine deiminase 1	Homo sapiens	161-164
22329812-2	2012	Chlorophyll a was converted into zinc methyl 3-ethylpyrochlorophyllide a (Chl) and then further modified at its 20-position to covalently attach a pyromellitimide (PI) acceptor bearing a pyridine ligand and one or two naphthalene-1,8:4,5-bis(dicarboximide) (NDI) secondary electron acceptors to give Chl-PI-NDI and Chl-PI-NDI(2).	pyridine	187-195	chordin like 1	Homo sapiens	0-3
22329812-2	2012	Chlorophyll a was converted into zinc methyl 3-ethylpyrochlorophyllide a (Chl) and then further modified at its 20-position to covalently attach a pyromellitimide (PI) acceptor bearing a pyridine ligand and one or two naphthalene-1,8:4,5-bis(dicarboximide) (NDI) secondary electron acceptors to give Chl-PI-NDI and Chl-PI-NDI(2).	pyridine	187-195	chordin like 1	Homo sapiens	74-77
22329812-6	2012	Charge recombination in the Chl-PI-NDI(2) cyclic tetramer (tau(CR) = 30 +- 1 ns in toluene) is slower by a factor of 3 relative to the monomeric building blocks (tau(CR) = 10 +- 1 ns in toluene-1% pyridine).	pyridine	197-205	chordin like 1	Homo sapiens	28-31
22329812-2	2012	Chlorophyll a was converted into zinc methyl 3-ethylpyrochlorophyllide a (Chl) and then further modified at its 20-position to covalently attach a pyromellitimide (PI) acceptor bearing a pyridine ligand and one or two naphthalene-1,8:4,5-bis(dicarboximide) (NDI) secondary electron acceptors to give Chl-PI-NDI and Chl-PI-NDI(2).	pyridine	187-195	chordin like 1	Homo sapiens	74-77
22329812-3	2012	The pyridine ligand within each ambident triad enables intermolecular Chl metal-ligand coordination in dry toluene, which results in the formation of cyclic tetramers in solution, as determined using small- and wide-angle X-ray scattering at a synchrotron source.	pyridine	4-12	chordin like 1	Homo sapiens	70-73
22329812-4	2012	Femtosecond and nanosecond transient absorption spectroscopy of the monomers in toluene-1% pyridine and the cyclic tetramers in toluene shows that the selective photoexcitation of Chl results in intramolecular electron transfer from (1*)Chl to PI to form Chl(+ )-PI(- )-NDI and Chl(+ )-PI(- )-NDI(2).	pyridine	91-99	chordin like 1	Homo sapiens	180-183
22132877-2	2012	The temperature for the decomposition of the precursors and the formation of CIS was lowered significantly to 130  C by using the strongly coordinating solvent pyridine instead of the commonly used water.	pyridine	160-168	cytokine inducible SH2 containing protein	Homo sapiens	77-80
22217868-2	2012	The four-component reaction of beta-keto ester, arylaldehyde, malononitrile and an alcohol provided a variety of pyridine derivatives and montmorillonite K-10 was found to be a reusable catalyst.	pyridine	113-121	keratin 10	Homo sapiens	154-158
22213187-0	2012	Pyridine-based lanthanide complexes combining MRI and NIR luminescence activities.	pyridine	0-8	NOC2 like nucleolar associated transcriptional repressor	Mus musculus	54-57
22324974-4	2012	When the precursor trans-[Ru(II)(dpp)Cl(2)] reacts with a bidentate (2,2"-bipyridine), tridentate (2,2";6,2""-terpyridine), or tetradentate (itself) ligand, a peripheral pyridine on dpp is displaced such that dpp binds as a tridentate.	pyridine	76-84	dentin sialophosphoprotein	Homo sapiens	33-36
22272694-0	2012	Host-guest supramolecular interactions in the coordination compounds of 4,4"-azobis(pyridine) with MnX2 (X = NCS-, NCNCN-, and PF6(-)): structural analyses and theoretical study.	pyridine	84-92	sperm associated antigen 17	Homo sapiens	127-130
22224431-5	2012	The stability of noncovalent binding is shown to correlate with the anticipated ability of the various pyridine ligands to interact with the hydrophobic binding domains of hsA.	pyridine	103-111	albumin	Homo sapiens	172-175
22041888-2	2012	The X-ray structural analysis exhibits that the three complexes show similar mononuclear structures, in which NIT-2Py radical chelates the Ln(III) ion through the oxygen atom of the NO group and the nitrogen atom from the pyridine ring.	pyridine	222-230	nitrilase family member 2	Homo sapiens	110-115
22202103-0	2012	Azines as histamine H4 receptor antagonists.	pyridine	0-6	histamine receptor H4	Homo sapiens	10-31
20638753-5	2012	To investigate a functional link between the disorders diabetes and AD, the effect of 2 AGEs, pentosidine and glyceraldehydes-derived pyridinium (GLAP), was studied on BACE1 expression both in vivo, in streptozotocin treated rats, and in vitro in differentiated neuroblastoma cells.	pyridine	134-144	beta-secretase 1	Rattus norvegicus	168-173
21989655-4	2011	Using pyridine (py) instead of thf leads to [(CO)(3)Fe{mu(2)-Zn(py)(2)}(3)Fe(CO)(3)] (3) via replacement of all GaCp* ligands by three{Zn(py)(2)} groups.	pyridine	6-14	glutaminase	Homo sapiens	112-116
21982158-6	2011	The thermal behavior of the complexes was investigated by using TGA method and dissociations indicated that substituted pyridine and ligand were leaved from coordination.	pyridine	120-128	T-box transcription factor 1	Homo sapiens	64-67
21986896-2	2011	Compound 1 is a polymer in which ligand L coordinates to tetrahedral Co(II) ions in a bidentate bridging fashion using the pyridine nitrogen and carbonyl oxygen atoms.	pyridine	123-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
21989655-4	2011	Using pyridine (py) instead of thf leads to [(CO)(3)Fe{mu(2)-Zn(py)(2)}(3)Fe(CO)(3)] (3) via replacement of all GaCp* ligands by three{Zn(py)(2)} groups.	pyridine	6-8	glutaminase	Homo sapiens	112-116
21204800-2	2011	The Ras proteins regulate cell proliferation and differentiation and neurofibromatosis type 1 (NF1) individuals have osteoclast hyperactivity and increased bone resorption as measured by urine pyridinium crosslinks [pyridinoline (Pyd) and deoxypyridinoline (Dpd)].	pyridine	193-203	neurofibromin 1	Homo sapiens	69-93
22199572-1	2011	In the title compound, [CoNa(2)(C(7)H(3)NO(4))(2)(H(2)O)(2)](n), the Co(II) atom is coordinated by two pyridine N atoms and four carboxyl-ate O atoms from two doubly deprotonated pyridine-2,6-dicarboxyl-ate ligands in a distorted octa-hedral geometry.	pyridine	103-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
21204800-2	2011	The Ras proteins regulate cell proliferation and differentiation and neurofibromatosis type 1 (NF1) individuals have osteoclast hyperactivity and increased bone resorption as measured by urine pyridinium crosslinks [pyridinoline (Pyd) and deoxypyridinoline (Dpd)].	pyridine	193-203	neurofibromin 1	Homo sapiens	95-98
22219826-1	2011	In the title compound, [Co(C(6)H(4)NO(2))(3)], the Co(III) ion lies on a threefold rotation axis and is in a distorted octa-hedral environment defined by three N and three O donor atoms from three fac-disposed pyridine-2-carboxyl-ate ligands.	pyridine	210-218	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	51-58
21703367-3	2011	It is shown that protonation of the pyridine ring of PLP in aspartate aminotransferase (AspAT) is achieved by (i) an intermolecular OHN hydrogen bond with an aspartate residue, assisted by the imidazole group of a histidine side chain and (ii) a local polarity as found for related model systems in a polar organic solvent exhibiting a dielectric constant of about 30.	pyridine	36-44	pyridoxal phosphatase	Homo sapiens	53-56
21868220-0	2011	Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors.	pyridine	15-23	diacylglycerol O-acyltransferase 1	Mus musculus	73-78
21816955-4	2011	The five beta-carbolines that we tested, which possess a pyridinium-like structure and are structurally related to the neurotoxin 1-methyl-4-phenylpyridinium, inhibited PMAT with high affinity (IC(50) values of 39.1-65.5 muM).	pyridine	57-67	solute carrier family 29 member 4	Homo sapiens	169-173
21905640-3	2011	When D-arabinose and D-ribose were silylated with tert-butyldiphenylsilyl chloride in pyridine at the hydroxyl groups at C-5 and acetylated at the other ones in a one-pot reaction, mixtures of anomeric 1-O-acetyl derivatives were obtained.	pyridine	86-94	complement C5	Homo sapiens	121-124
21703367-4	2011	Model studies indicate that protonation of the pyridine ring of PLP leads to a dominance of the ketoenamine form, where the intramolecular OHN hydrogen bond of PLP exhibits a zwitterionic state.	pyridine	47-55	pyridoxal phosphatase	Homo sapiens	64-67
21703367-4	2011	Model studies indicate that protonation of the pyridine ring of PLP leads to a dominance of the ketoenamine form, where the intramolecular OHN hydrogen bond of PLP exhibits a zwitterionic state.	pyridine	47-55	pyridoxal phosphatase	Homo sapiens	160-163
21852207-6	2011	The results indicate that the lipase maximum purification and recovery were obtained for cations with a C(8) side alkyl chain, the [N(CN)(2)] anion and ILs belonging to the pyridinium family.	pyridine	173-183	PAN0_003d1715	Moesziomyces antarcticus	30-36
21827189-0	2011	Role of the pyridine nitrogen in pyridoxal 5"-phosphate catalysis: activity of three classes of PLP enzymes reconstituted with deazapyridoxal 5"-phosphate.	pyridine	12-20	pyridoxal phosphatase	Homo sapiens	96-99
21827189-8	2011	Not all PLP enzymes require the electrophilicity of a protonated pyridine ring to enable formation of carbanionic intermediates.	pyridine	65-73	pyridoxal phosphatase	Homo sapiens	8-11
21680215-6	2011	The hydrogen-bond acceptor was the pyridine nitrogen of NNK in the CYP2A13 complex, but it changed to the carbonyl oxygen in the CYP2A6 complex.	pyridine	35-43	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	67-74
21646436-8	2011	The IC(50) values were 0.1, 3.8, 14, and 671 muM (hexyl-, butyl-, and ethyl-pyridinium and pyridinium chloride) for rOCT2-mediated metformin transport.	pyridine	91-110	solute carrier family 22 member 2	Rattus norvegicus	116-121
21680215-6	2011	The hydrogen-bond acceptor was the pyridine nitrogen of NNK in the CYP2A13 complex, but it changed to the carbonyl oxygen in the CYP2A6 complex.	pyridine	35-43	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	129-135
21778980-4	2011	The reactions are efficiently catalysed by dearomatized PNN Ru(II) pincer complexes derived from pyridine- and bipyridine-based tridentate ligands.	pyridine	97-105	pinin, desmosome associated protein	Homo sapiens	56-59
21605206-2	2011	Here, we analyzed how duplicated genes encoding quinolinate phosphoribosyltransferase (QPT), an enzyme involved in the synthesis of nicotinamide adenine dinucleotide (NAD) and the pyridine moiety of nicotine, are regulated by the jasmonate-responsive transcriptional factor ERF189 that functions critically for nicotine biosynthesis in tobacco (Nicotiana tabacum).	pyridine	180-188	nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic-like	Nicotiana tabacum	48-85
21605206-2	2011	Here, we analyzed how duplicated genes encoding quinolinate phosphoribosyltransferase (QPT), an enzyme involved in the synthesis of nicotinamide adenine dinucleotide (NAD) and the pyridine moiety of nicotine, are regulated by the jasmonate-responsive transcriptional factor ERF189 that functions critically for nicotine biosynthesis in tobacco (Nicotiana tabacum).	pyridine	180-188	nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic-like	Nicotiana tabacum	87-90
21605206-2	2011	Here, we analyzed how duplicated genes encoding quinolinate phosphoribosyltransferase (QPT), an enzyme involved in the synthesis of nicotinamide adenine dinucleotide (NAD) and the pyridine moiety of nicotine, are regulated by the jasmonate-responsive transcriptional factor ERF189 that functions critically for nicotine biosynthesis in tobacco (Nicotiana tabacum).	pyridine	180-188	ethylene-responsive transcription factor 13-like	Nicotiana tabacum	274-280
21605206-7	2011	These results indicate that one copy of the duplicated QPT genes was recruited to a tobacco alkaloid regulon by evolving multiple target cis-regulatory elements of ERF189 in its promoter, to cope with an increased metabolic demand for pyridine precursors during active alkaloid biosynthesis.	pyridine	235-243	nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic-like	Nicotiana tabacum	55-58
21605206-7	2011	These results indicate that one copy of the duplicated QPT genes was recruited to a tobacco alkaloid regulon by evolving multiple target cis-regulatory elements of ERF189 in its promoter, to cope with an increased metabolic demand for pyridine precursors during active alkaloid biosynthesis.	pyridine	235-243	ethylene-responsive transcription factor 13-like	Nicotiana tabacum	164-170
21315710-0	2011	Synthesized pyridine compound derivatives decreased TNF alpha and adhesion molecules and ameliorated HSV-induced inflammation in a mouse model.	pyridine	12-20	tumor necrosis factor	Mus musculus	52-61
21754669-1	2011	In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))(2)](n), the Co(II) ion is located on an inversion center and is six-coordinated in an octa-hedral environment defined by four N atoms of the pyridine rings and two O atoms of the nitrate anions.	pyridine	198-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
20655719-4	2011	In addition to the known Nrf2 activator 5-O-caffeoylquinic acid (CGA), pyridinium derivatives like the N-methylpyridinium ion (NMP) were identified as potent activators of Nrf2 nuclear translocation and ARE-dependent gene expression of selected antioxidative Phase II enzymes in HT29.	pyridine	71-81	NFE2 like bZIP transcription factor 2	Homo sapiens	172-176
20655719-5	2011	Thereby, the substitution pattern at the pyridinium core structure determined the impact on Nrf2-signalling.	pyridine	41-51	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
21522843-1	2011	In the title coordination polymer, [Pb(C(7)H(3)NO(4))](n), the Pb(II) ion is eight-coordinated in a distorted square-anti-prismatic geometry formed by one pyridine N atom and seven carboxyl-ate O atoms from four pyridine-2,3-dicarboxyl-ate (pda) anions.	pyridine	155-163	submaxillary gland androgen regulated protein 3B	Homo sapiens	63-69
21384875-1	2011	Pyridine substituted 3,4-dihydro-1H-quinolin-2-ones (e.g., 1-3) constitute a class of highly potent and selective inhibitors of aldosterone synthase (CYP11B2), a promising target for the treatment of hyperaldosteronism, congestive heart failure, and myocardial fibrosis.	pyridine	0-8	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	128-148
21384875-1	2011	Pyridine substituted 3,4-dihydro-1H-quinolin-2-ones (e.g., 1-3) constitute a class of highly potent and selective inhibitors of aldosterone synthase (CYP11B2), a promising target for the treatment of hyperaldosteronism, congestive heart failure, and myocardial fibrosis.	pyridine	0-8	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	150-157
21421318-1	2011	The quinoline nucleus of the previously described 4-phenylquinoline-3-carboxamides NK(1) receptor ligands 7 has been transformed into either substituted or azole-(i.e., triazole or tetrazole) fused pyridine moieties of compounds 9 and 10, respectively, in order to obtain NK(1) receptor ligands showing lower molecular weight or higher hydrophilicity.	pyridine	198-206	tachykinin receptor 1	Homo sapiens	83-97
21314092-3	2011	NBO analysis of calculated cations with varying electron demand (B3LYP/6-311++G**) show that C-Se hyperconjugation (sigma(C-Se)-pi*) is the predominant mode of stabilization in the weakly electron-demanding pyridinium ions (10d, 11d, 14, and 15); however, the through-space (n(Se)-pi*) interaction becomes more important as the electron demand of the beta-Se-substituted carbocation increases.	pyridine	207-217	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	93-97
21314092-3	2011	NBO analysis of calculated cations with varying electron demand (B3LYP/6-311++G**) show that C-Se hyperconjugation (sigma(C-Se)-pi*) is the predominant mode of stabilization in the weakly electron-demanding pyridinium ions (10d, 11d, 14, and 15); however, the through-space (n(Se)-pi*) interaction becomes more important as the electron demand of the beta-Se-substituted carbocation increases.	pyridine	207-217	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	122-126
21232776-0	2011	RNAi-mediated down-regulation of ornithine decarboxylase (ODC) leads to reduced nicotine and increased anatabine levels in transgenic Nicotiana tabacum L. In leaf and root tissues of Nicotiana tabacum L. (common tobacco), nicotine is by far the predominant pyridine alkaloid, with anatabine representing only a minor component of the total alkaloid fraction.	pyridine	257-265	ornithine decarboxylase	Nicotiana tabacum	33-56
21232776-0	2011	RNAi-mediated down-regulation of ornithine decarboxylase (ODC) leads to reduced nicotine and increased anatabine levels in transgenic Nicotiana tabacum L. In leaf and root tissues of Nicotiana tabacum L. (common tobacco), nicotine is by far the predominant pyridine alkaloid, with anatabine representing only a minor component of the total alkaloid fraction.	pyridine	257-265	ornithine decarboxylase	Nicotiana tabacum	58-61
21104302-1	2011	PURPOSE: The goal of this study was to test the hypothesis that by controlling intracellular uptake, organic cation transporter 1, Oct1 is a key determinant of the disposition and toxicity of cis-diammine(pyridine)chloroplatinum(II)(CDPCP) and oxaliplatin.	pyridine	205-213	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	101-129
21104302-1	2011	PURPOSE: The goal of this study was to test the hypothesis that by controlling intracellular uptake, organic cation transporter 1, Oct1 is a key determinant of the disposition and toxicity of cis-diammine(pyridine)chloroplatinum(II)(CDPCP) and oxaliplatin.	pyridine	205-213	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	131-135
21338922-2	2011	We performed a small molecule screen for left-right asymmetry phenotypes in Xenopus embryos and discovered a pyridine analog, heterotaxin, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-beta-dependent left-right asymmetric gene expression.	pyridine	109-117	transforming growth factor beta 1 L homeolog	Xenopus laevis	218-226
21174471-3	2011	Moreover, with the assistance of pyridine, a CuBr-3a system promotes the diastereoselective Henry reaction with various aldehyde substrates and gives the corresponding syn-selective adduct with up to a 99% yield and 32.3:1 syn/anti selectivity.	pyridine	33-41	synemin	Homo sapiens	168-171
21174471-3	2011	Moreover, with the assistance of pyridine, a CuBr-3a system promotes the diastereoselective Henry reaction with various aldehyde substrates and gives the corresponding syn-selective adduct with up to a 99% yield and 32.3:1 syn/anti selectivity.	pyridine	33-41	synemin	Homo sapiens	223-226
21818972-3	2011	RESULTS: There are two main fragment pathway for m/z 355 [M + H]+ by ESI-MS2 and the fragment broken in pyridine ring.	pyridine	104-112	MS2	Homo sapiens	73-76
21163664-3	2011	From these X-ray co-crystallography results, to achieve more potent inhibitory activity, we targeted Arg125 as a potential amino acid residue because it was located near the pyridine core, and some known DPP-4 inhibitors were reported to interact with this residue.	pyridine	174-182	dipeptidyl peptidase 4	Homo sapiens	204-209
21866770-1	2011	Cellulose acetate/ polyacrylonitrile (CA/PAN) membranes were prepared and used to separate pyridine / water mixtures by pervaporation.	pyridine	91-99	adenosine deaminase 2	Homo sapiens	0-44
20951039-4	2010	We found that electron density in the pyridine region greatly influences activity of our inhibitors at ATX.	pyridine	38-46	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	103-106
21125574-8	2010	The R=P(OPh)(3) complex was most reactive due to its pi-acid character, which favors the rupture of the trans nitrogen-palladium bond in the A-2 mechanism and also that of the pyridine nitrogen-palladium bond in the A-1 mechanism.	pyridine	176-184	BCL2 related protein A1	Homo sapiens	216-219
21050768-4	2010	The other was the replacement of the phenyl ring with a pyridine ring to improve in vivo potency and reduce hERG affinity.	pyridine	56-64	ETS transcription factor ERG	Homo sapiens	108-112
20960446-2	2010	For the synthesis of amythiamicin C, this step was followed by a Negishi cross-coupling at C-6 of the pyridine core.	pyridine	102-110	complement C6	Homo sapiens	91-94
20923496-3	2010	Type 1 diabetes) on 11beta-HSD1 or endoplasmic reticulum enzymes that generate the reduced pyridine cofactor NADPH.	pyridine	91-99	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	20-31
20830377-1	2010	A novel robust pyridine-bridged bis-benzimidazolylidene nickel pincer complex 3 accessible from inexpensive, commercially available precursors efficiently catalyzes the first practical Suzuki-Miyaura cross-coupling reactions with various less-reactive electrophiles ArX (X = Br, Cl, OTs and OMs) and even tolerates electron-rich, sterically demanding and heterocyclic arenes in the presence of catalytic amounts of PPh(3).	pyridine	15-23	aristaless related homeobox	Homo sapiens	266-269
20933415-0	2010	Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.	pyridine	40-48	cathepsin L	Homo sapiens	110-121
20877832-3	2010	This report describes new findings of an investigation of the SERS characteristics for the competitive adsorption of dipicolinic acid (DPA), which is an important biomarker from bacterial spores, and pyridine (Py), which is a possible decarboxylation product of DPA.	pyridine	200-208	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	62-66
20877832-3	2010	This report describes new findings of an investigation of the SERS characteristics for the competitive adsorption of dipicolinic acid (DPA), which is an important biomarker from bacterial spores, and pyridine (Py), which is a possible decarboxylation product of DPA.	pyridine	210-212	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	62-66
20566409-3	2010	Herein, we describe the identification of a novel series of structurally related pyridine derivatives as potent Na(v)1.8 channel blockers.	pyridine	81-89	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	112-120
20963734-3	2010	Theoretical studies using density functional theory predict a bond dissociation energy (BDE) of BDE[(py)(2) Cu(+) -Cl] = 125 kJ mol(-1) , whereas the pyridine ligand is bound significantly stronger, i.e. BDE[(py)CuCl(+) -py] = 194 kJ mol(-1) and BDE[(py)Cu(+) -py] = 242 kJ mol(-1) .	pyridine	101-103	homeobox D13	Homo sapiens	88-91
20963734-3	2010	Theoretical studies using density functional theory predict a bond dissociation energy (BDE) of BDE[(py)(2) Cu(+) -Cl] = 125 kJ mol(-1) , whereas the pyridine ligand is bound significantly stronger, i.e. BDE[(py)CuCl(+) -py] = 194 kJ mol(-1) and BDE[(py)Cu(+) -py] = 242 kJ mol(-1) .	pyridine	101-103	homeobox D13	Homo sapiens	96-99
20963734-3	2010	Theoretical studies using density functional theory predict a bond dissociation energy (BDE) of BDE[(py)(2) Cu(+) -Cl] = 125 kJ mol(-1) , whereas the pyridine ligand is bound significantly stronger, i.e. BDE[(py)CuCl(+) -py] = 194 kJ mol(-1) and BDE[(py)Cu(+) -py] = 242 kJ mol(-1) .	pyridine	101-103	homeobox D13	Homo sapiens	96-99
20963734-3	2010	Theoretical studies using density functional theory predict a bond dissociation energy (BDE) of BDE[(py)(2) Cu(+) -Cl] = 125 kJ mol(-1) , whereas the pyridine ligand is bound significantly stronger, i.e. BDE[(py)CuCl(+) -py] = 194 kJ mol(-1) and BDE[(py)Cu(+) -py] = 242 kJ mol(-1) .	pyridine	101-103	homeobox D13	Homo sapiens	96-99
20963734-3	2010	Theoretical studies using density functional theory predict a bond dissociation energy (BDE) of BDE[(py)(2) Cu(+) -Cl] = 125 kJ mol(-1) , whereas the pyridine ligand is bound significantly stronger, i.e. BDE[(py)CuCl(+) -py] = 194 kJ mol(-1) and BDE[(py)Cu(+) -py] = 242 kJ mol(-1) .	pyridine	216-223	homeobox D13	Homo sapiens	88-91
20963734-3	2010	Theoretical studies using density functional theory predict a bond dissociation energy (BDE) of BDE[(py)(2) Cu(+) -Cl] = 125 kJ mol(-1) , whereas the pyridine ligand is bound significantly stronger, i.e. BDE[(py)CuCl(+) -py] = 194 kJ mol(-1) and BDE[(py)Cu(+) -py] = 242 kJ mol(-1) .	pyridine	216-223	homeobox D13	Homo sapiens	96-99
20963734-3	2010	Theoretical studies using density functional theory predict a bond dissociation energy (BDE) of BDE[(py)(2) Cu(+) -Cl] = 125 kJ mol(-1) , whereas the pyridine ligand is bound significantly stronger, i.e. BDE[(py)CuCl(+) -py] = 194 kJ mol(-1) and BDE[(py)Cu(+) -py] = 242 kJ mol(-1) .	pyridine	216-223	homeobox D13	Homo sapiens	96-99
20963734-3	2010	Theoretical studies using density functional theory predict a bond dissociation energy (BDE) of BDE[(py)(2) Cu(+) -Cl] = 125 kJ mol(-1) , whereas the pyridine ligand is bound significantly stronger, i.e. BDE[(py)CuCl(+) -py] = 194 kJ mol(-1) and BDE[(py)Cu(+) -py] = 242 kJ mol(-1) .	pyridine	216-223	homeobox D13	Homo sapiens	96-99
20822184-5	2010	Structure-activity relationship (SAR) analyses suggest that the introduction of additional substituents to the amino group present on the pyridine ring of the N-demethylated analogue of compound 17 can provide potent alpha4beta2-nAChR-selective ligands for possible use in treatment of neurological and psychiatric disorders including depression.	pyridine	138-146	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	229-234
20683516-7	2010	The non-acidic OH groups on HY zeolite [3], which were BAS on HY zeolite [1], hydrogen-bonded to pyridine to show IR spectra similar to those adsorbed on LAS.	pyridine	97-105	lipoic acid synthetase	Homo sapiens	154-157
20683516-8	2010	Thus, LAS on HY zeolite [3] seemed irreversible by pyridine adsorption after water re-adsorption.	pyridine	51-59	lipoic acid synthetase	Homo sapiens	6-9
20721385-1	2010	NAD 2D NMR spectroscopy using chiral mesophases made of poly-gamma-benzyl-l-glutamate and pyridine allowed us to evaluate, for the first time, the natural site-specific enantio-isotopomeric excesses at each methylene group of linoleic acid, a central, essential PUFA precursor of all conjugated triene fatty acids.	pyridine	90-98	pumilio RNA binding family member 3	Homo sapiens	262-266
20567819-3	2010	A comparative study showed that the lipase had much higher catalytic activity in the binary mixture of hexane and pyridine than in other tested co-solvent systems.	pyridine	114-122	PAN0_003d1715	Moesziomyces antarcticus	36-42
20580787-1	2010	A novel pyridine derivative, 8-{4-[(6-methoxy-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-3-ylmethyl)-amino]-butyl}-8-aza-spiro[4.5]decane-7,9-dione hydrochloride, termed JB-788, was designed to selectively target 5-HT(1A) receptors.	pyridine	8-16	5-hydroxytryptamine receptor 1A	Homo sapiens	210-217
20963734-3	2010	Theoretical studies using density functional theory predict a bond dissociation energy (BDE) of BDE[(py)(2) Cu(+) -Cl] = 125 kJ mol(-1) , whereas the pyridine ligand is bound significantly stronger, i.e. BDE[(py)CuCl(+) -py] = 194 kJ mol(-1) and BDE[(py)Cu(+) -py] = 242 kJ mol(-1) .	pyridine	150-158	homeobox D13	Homo sapiens	88-91
20963734-3	2010	Theoretical studies using density functional theory predict a bond dissociation energy (BDE) of BDE[(py)(2) Cu(+) -Cl] = 125 kJ mol(-1) , whereas the pyridine ligand is bound significantly stronger, i.e. BDE[(py)CuCl(+) -py] = 194 kJ mol(-1) and BDE[(py)Cu(+) -py] = 242 kJ mol(-1) .	pyridine	150-158	homeobox D13	Homo sapiens	96-99
20963734-3	2010	Theoretical studies using density functional theory predict a bond dissociation energy (BDE) of BDE[(py)(2) Cu(+) -Cl] = 125 kJ mol(-1) , whereas the pyridine ligand is bound significantly stronger, i.e. BDE[(py)CuCl(+) -py] = 194 kJ mol(-1) and BDE[(py)Cu(+) -py] = 242 kJ mol(-1) .	pyridine	150-158	homeobox D13	Homo sapiens	96-99
20963734-3	2010	Theoretical studies using density functional theory predict a bond dissociation energy (BDE) of BDE[(py)(2) Cu(+) -Cl] = 125 kJ mol(-1) , whereas the pyridine ligand is bound significantly stronger, i.e. BDE[(py)CuCl(+) -py] = 194 kJ mol(-1) and BDE[(py)Cu(+) -py] = 242 kJ mol(-1) .	pyridine	150-158	homeobox D13	Homo sapiens	96-99
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	pyridine	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	pyridine	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
20822182-0	2010	Selective C-4 alkylation of pyridine by nickel/Lewis acid catalysis.	pyridine	28-36	complement C4A (Rodgers blood group)	Homo sapiens	10-13
20822182-1	2010	Direct C-4-selective addition of pyridine across alkenes and alkynes is achieved for the first time by nickel/Lewis acid cooperative catalysis with an N-heterocyclic carbene ligand.	pyridine	33-41	complement C4A (Rodgers blood group)	Homo sapiens	7-10
20690626-0	2010	Bimetallic nickel aluminum mediated para-selective alkenylation of pyridine: direct observation of eta2,eta1-pyridine Ni(0)-Al(III) intermediates prior to C-H bond activation.	pyridine	67-75	DNA polymerase iota	Homo sapiens	99-103
20690626-0	2010	Bimetallic nickel aluminum mediated para-selective alkenylation of pyridine: direct observation of eta2,eta1-pyridine Ni(0)-Al(III) intermediates prior to C-H bond activation.	pyridine	67-75	secreted phosphoprotein 1	Homo sapiens	104-108
20690626-1	2010	We have presented new amino-NHC Ni-Al complex mediated para C-H bond activation for pyridine and quinolin, and isolated for the first time the intermediate structure of a bimetallic eta(2),eta(1)-pyridine nickel aluminum complex prior to its C-H activation, which serves as key evidence for bimetallic catalysis.	pyridine	84-92	DNA polymerase iota	Homo sapiens	182-187
20378363-0	2010	Elaborate ligand-based pharmacophore exploration and QSAR analysis guide the synthesis of novel pyridinium-based potent beta-secretase inhibitory leads.	pyridine	96-106	beta-secretase 1	Homo sapiens	120-134
20234191-5	2010	Here, we analyze PND-1186, a substituted pyridine reversible inhibitor of FAK activity with a 50% inhibitory concentration (IC50) of 1.5 nM in vitro.	pyridine	41-49	PTK2 protein tyrosine kinase 2	Mus musculus	74-77
20546883-5	2010	The location of groups on the pyridine ring also influences passive transport into the brain; the optimum position of the oxime group was found to be position four (para) and substitution of the oxime group on the pyridine ring by carbamoyl or amidoxime group markedly decreased penetration of AChE reactivators into the CNS.	pyridine	30-38	acetylcholinesterase (Cartwright blood group)	Homo sapiens	294-298
20615716-3	2010	The most active and selective derivative (20), bearing a pyridine moiety on the CN, displayed IC(50)=3.81+/-0.12 nM and selectivity ratio=119 toward hMAO-B.	pyridine	57-65	monoamine oxidase B	Homo sapiens	149-155
21787634-1	2010	Two newly developed AChE reactivators possessing two oxime groups in 4-position of the pyridinium rings with linkers CH(2)O(CH(2))(2)OCH(2) and CH(2)O(CH(2))(4)OCH(2) were tested for their potency to reactivate VX-inhibited AChE.	pyridine	87-97	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-24
20394349-2	2010	The pyridine nitrogen in PLP in the wild-type enzyme is unprotonated due to interaction with Arg219, a rare feature among PLP-dependent enzymes.	pyridine	4-12	pyridoxal phosphatase	Homo sapiens	25-28
20394349-2	2010	The pyridine nitrogen in PLP in the wild-type enzyme is unprotonated due to interaction with Arg219, a rare feature among PLP-dependent enzymes.	pyridine	4-12	pyridoxal phosphatase	Homo sapiens	122-125
20359891-2	2010	Extensive SAR studies led to the discovery of pyridine-containing cyclic prodrug 20, which strongly inhibited glucose production in monkey hepatocytes and also showed weak CYP3A4 inhibitory potency.	pyridine	46-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	172-178
20378363-5	2010	QSAR equation and pharmacophoric models were validated through ROC curves and were employed to guide synthesis of novel pyridinium-based BACE inhibitors.	pyridine	120-130	beta-secretase 1	Homo sapiens	137-141
20153225-0	2010	Why pyridine containing pyrido[2,3-d]pyrimidin-7-ones selectively inhibit CDK4 than CDK2: insights from molecular dynamics simulation.	pyridine	4-12	cyclin dependent kinase 4	Homo sapiens	74-78
20153225-6	2010	The pyridine nitrogen (N(AR)) of lig17 was capable of interacting with His95 (CDK4) through hydrogen bonding.	pyridine	4-12	cyclin dependent kinase 4	Homo sapiens	78-82
20346653-3	2010	Based on the structural similarities between the initial hit and a well-known imidazole pyrimidine series of p38alpha inhibitors, potencies within the newly discovered series were quickly improved by installation of an (S)-alpha-methylbenzyl moiety at the 2-position of the pyridine ring.	pyridine	274-282	mitogen-activated protein kinase 14	Homo sapiens	109-117
20201487-2	2010	Crystal structures of the triflate salts of m-1, p-1, and 4 show that amide NH and pyridinium o-CH groups are directed inside the receptor cleft with their four protons forming a circle of radius ca.	pyridine	83-93	crystallin gamma F, pseudogene	Homo sapiens	49-52
20153225-0	2010	Why pyridine containing pyrido[2,3-d]pyrimidin-7-ones selectively inhibit CDK4 than CDK2: insights from molecular dynamics simulation.	pyridine	4-12	cyclin dependent kinase 2	Homo sapiens	84-88
20179854-4	2010	The compound (2) reacts in donor solvent such as pyridine to form six-coordinate diamagnetic species of the type Co(N-NCO(o-O)C(6)H(4)-tpp)(py) (4), whose (1)H NMR spectra can be interpreted as for Co(III) in an octahedral environment.	pyridine	49-57	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	198-205
20205396-4	2010	Studies of the binding of various substrates (pyridine, dmso, ethylene and methyl acrylate) to 3-meso and 3-rac show that hindered displacement of the chelating carbonyl moiety by pi-coordination of incoming monomer significantly retards, but does not prohibit, polymerization.	pyridine	46-54	AKT serine/threonine kinase 1	Homo sapiens	108-111
20127783-9	2010	These hydron transfers occur along strong (D(+))H(+) bonds of pyridinium ions with pyridine (BB1) and DPPC C=O groups (BB2).	pyridine	62-72	neuromedin B receptor	Homo sapiens	93-96
19715547-0	2010	Association constants of pyridine and piperidine alkaloids to amyloid beta peptide determined by electrochemical impedance spectroscopy.	pyridine	25-33	amyloid beta precursor protein	Homo sapiens	62-74
20127783-9	2010	These hydron transfers occur along strong (D(+))H(+) bonds of pyridinium ions with pyridine (BB1) and DPPC C=O groups (BB2).	pyridine	62-72	gastrin releasing peptide receptor	Homo sapiens	119-122
20127783-9	2010	These hydron transfers occur along strong (D(+))H(+) bonds of pyridinium ions with pyridine (BB1) and DPPC C=O groups (BB2).	pyridine	83-91	neuromedin B receptor	Homo sapiens	93-96
19938875-3	2010	Moreover, protonation of the PLP pyridine nitrogen further drives the equilibrium toward the oxoenamine direction.	pyridine	33-41	proteolipid protein 1	Homo sapiens	29-32
20030386-3	2010	Suzuki reactions at C-4 and C-3 of the pyridine ring proceeded with moderate to high yields.	pyridine	39-47	complement C4A (Rodgers blood group)	Homo sapiens	20-23
20030386-3	2010	Suzuki reactions at C-4 and C-3 of the pyridine ring proceeded with moderate to high yields.	pyridine	39-47	complement C3	Homo sapiens	28-31
20030386-5	2010	Starting from an arylated propargylic ether the three-component reaction led to a pentasubstituted 4-hydroxypyridine derivative that could also be employed in palladium-catalyzed processes at C-4 and at C-3 of the pyridine core.	pyridine	108-116	complement C4A (Rodgers blood group)	Homo sapiens	192-195
20030386-5	2010	Starting from an arylated propargylic ether the three-component reaction led to a pentasubstituted 4-hydroxypyridine derivative that could also be employed in palladium-catalyzed processes at C-4 and at C-3 of the pyridine core.	pyridine	108-116	complement C3	Homo sapiens	203-206
20006497-0	2010	2,3,5-Trisubstituted pyridines as selective AKT inhibitors-Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity.	pyridine	21-29	AKT serine/threonine kinase 1	Homo sapiens	44-47
20006497-0	2010	2,3,5-Trisubstituted pyridines as selective AKT inhibitors-Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity.	pyridine	21-29	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	119-124
20006497-2	2010	Substitution at the 2-position of the core pyridine is the key element to provide selectivity against ROCK1.	pyridine	43-51	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	102-107
19938875-6	2010	Both Asp271 and Lys303 stabilize the hydroxyimine configuration through hydrogen-bonding interactions with the pyridine nitrogen of the PLP and the imino nitrogen of the Schiff base, respectively.	pyridine	111-119	proteolipid protein 1	Homo sapiens	136-139
19899817-7	2009	The energies for the adsorption of ethene, benzene, ethylbenzene, and pyridine on H-ZSM-5 from an embedded ONIOM(MP2:M06-2X) calculation are predicted to be -14.0, -19.8, -24.7, and -48.4 kcal/mol, respectively, which are very close to available experimental observations.	pyridine	70-78	tryptase pseudogene 1	Homo sapiens	113-116
19839596-2	2009	A colorimetric assay to measure hippuric acid (HA) was transformed into a rapid ACE assay wherein the released HA from the substrate hippuryl-histidyl-leucine (HHL) is mixed with pyridine and benzene sulfonyl chloride.	pyridine	179-187	angiotensin I converting enzyme	Homo sapiens	80-83
19780566-2	2009	The crystal structure determinations of 1 and 2 reveal in both cases discrete iron(II) monomeric structures in which the two functionalized tetraazamacrocycles (L1 and L2) act as hexadentate ligands; the iron(II) ions are coordinated with six nitrogen atoms: four from the macrocycle and two from two pyridine groups occupying two cis positions around the metal ion.	pyridine	301-309	L1 cell adhesion molecule	Homo sapiens	161-170
19791801-0	2009	Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors.	pyridine	0-8	prostaglandin-endoperoxide synthase 1	Homo sapiens	118-140
19773164-2	2009	Introduction of diversity at the 6-position of the pyridine ring was designed to enhance in vitro potency and decrease hERG activity.	pyridine	51-59	ETS transcription factor ERG	Homo sapiens	119-123
19757823-4	2009	These strategies enabled us to integrate pyridine and pyrimidine groups on 3 extending deep into the S3 region of the BACE1 binding pocket and enhancing the ligand"s potency.	pyridine	41-49	beta-secretase 1	Homo sapiens	118-123
19736007-0	2009	Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists.	pyridine	6-14	cannabinoid receptor 2	Rattus norvegicus	51-54
19736007-1	2009	Replacement of the phenyl ring in our previous (morpholinomethyl)aniline carboxamide cannabinoid receptor ligands with a pyridine ring led to the discovery of a novel chemical series of CB2 ligands.	pyridine	121-129	cannabinoid receptor 2	Rattus norvegicus	186-189
19791801-3	2009	In the present study, we report the synthesis and the pharmacological evaluation of pyridine analogues of nimesulide, a COX-2 preferential inhibitor.	pyridine	84-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
19653646-11	2009	Treatment of trans-Mo(NCMe)(CO)(3)(CNAr(Dipp2))(2) with the Lewis base pyridine (py) affords the complex fac,cis-Mo(py)(CO)(3)(CNAr(Dipp2))(2) as determined by X-ray diffraction.	pyridine	71-79	nudix hydrolase 4	Homo sapiens	40-45
19665800-3	2009	Electrochemical data in methanol revealed that the Co(III)--&gt;Co(II) reduction of 1 (-0.84V vs. normal hydrogen electrode - NHE) is more positive than 2 (-1.13V vs. NHE), while it was expected to be more negative due to better sigma-donor ability of imidazole ring in HL1, compared to pyridine in HL2.	pyridine	287-295	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	54-57
19665800-3	2009	Electrochemical data in methanol revealed that the Co(III)--&gt;Co(II) reduction of 1 (-0.84V vs. normal hydrogen electrode - NHE) is more positive than 2 (-1.13V vs. NHE), while it was expected to be more negative due to better sigma-donor ability of imidazole ring in HL1, compared to pyridine in HL2.	pyridine	287-295	solute carrier family 9 member C1	Homo sapiens	126-129
19665800-3	2009	Electrochemical data in methanol revealed that the Co(III)--&gt;Co(II) reduction of 1 (-0.84V vs. normal hydrogen electrode - NHE) is more positive than 2 (-1.13V vs. NHE), while it was expected to be more negative due to better sigma-donor ability of imidazole ring in HL1, compared to pyridine in HL2.	pyridine	287-295	solute carrier family 9 member C1	Homo sapiens	167-170
19682896-2	2009	Keeping the group at C-4 of the pyridine core constant, we varied the water solubilizing group on the phenyl ring at C-5 and then replaced the C-5 phenyl ring with several monocyclic heteroaryl rings, including furan, thiophene and pyridine.	pyridine	32-40	complement C4A (Rodgers blood group)	Homo sapiens	21-24
19505093-5	2009	The UV-vis analysis results indicate that the LBL TRDC-BPR self-assembled multilayer films with axial ligands between ruthenium atoms and pyridine groups were successfully fabricated and the progressive assembly runs regularly with almost equal amounts of deposition in each cycle.	pyridine	138-146	T cell receptor delta constant	Homo sapiens	50-54
19669997-1	2009	Monoamine oxidase (MAO) B is a mitochondrial enzyme selectively involved in the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to toxic pyridinium cations producing Parkinsonism in animal models.	pyridine	176-186	monoamine oxidase B	Homo sapiens	0-25
19653646-11	2009	Treatment of trans-Mo(NCMe)(CO)(3)(CNAr(Dipp2))(2) with the Lewis base pyridine (py) affords the complex fac,cis-Mo(py)(CO)(3)(CNAr(Dipp2))(2) as determined by X-ray diffraction.	pyridine	71-79	nudix hydrolase 4	Homo sapiens	132-137
19453176-0	2009	Cp(2)Ni-KOt-Bu-BEt(3) (or PPh(3)) catalyst system for direct C-H arylation of benzene, naphthalene, and pyridine.	pyridine	104-112	trafficking protein particle complex subunit 3	Homo sapiens	15-21
19618936-1	2009	The displacement of eta(2)-coordinated ligands from the photolytically generated CpMn(CO)(2)L and BzCr(CO)(2)L [Cp = eta(5)-C(5)H(5), Bz = eta(6)-C(6)H(6), L = 2,3-dihydrofuran (DHF), furan] complexes by pyridine has been studied.	pyridine	204-212	endothelin receptor type A	Homo sapiens	20-23
19453176-0	2009	Cp(2)Ni-KOt-Bu-BEt(3) (or PPh(3)) catalyst system for direct C-H arylation of benzene, naphthalene, and pyridine.	pyridine	104-112	caveolin 1	Homo sapiens	26-32
19453176-3	2009	This Ni catalyst system was also applied to direct C-H arylation of pyridine, an electron-deficient heteroarene; PPh(3) was used instead of BEt(3) in this case.	pyridine	68-76	caveolin 1	Homo sapiens	113-119
19453176-3	2009	This Ni catalyst system was also applied to direct C-H arylation of pyridine, an electron-deficient heteroarene; PPh(3) was used instead of BEt(3) in this case.	pyridine	68-76	trafficking protein particle complex subunit 3	Homo sapiens	140-146
19342207-7	2009	CYP1A1, iNOS and MT expression levels were elevated in liver, kidney and heart in response to acute pyridine toxicity.	pyridine	100-108	cytochrome P450 1A1	Mesocricetus auratus	0-6
19328688-2	2009	N-Oxide pyridine analog (7b) was identified as a promising FXR agonist with potent binding affinity and good efficacy, supporting our hypothesis that through an additional hydrogen bond interaction between the pyridine substituent of isoxazole analogs and Tyr373 and Ser336 of FXR, binding affinity and functional activity could be improved.	pyridine	8-16	nuclear receptor subfamily 1 group H member 4	Homo sapiens	59-62
19328688-2	2009	N-Oxide pyridine analog (7b) was identified as a promising FXR agonist with potent binding affinity and good efficacy, supporting our hypothesis that through an additional hydrogen bond interaction between the pyridine substituent of isoxazole analogs and Tyr373 and Ser336 of FXR, binding affinity and functional activity could be improved.	pyridine	8-16	nuclear receptor subfamily 1 group H member 4	Homo sapiens	277-280
19342207-0	2009	Pyridine induction of cytochrome P450 1A1, iNOS and metallothionein in Syrian hamsters and protective effects of silymarin.	pyridine	0-8	cytochrome P450 1A1	Mesocricetus auratus	22-41
19342207-7	2009	CYP1A1, iNOS and MT expression levels were elevated in liver, kidney and heart in response to acute pyridine toxicity.	pyridine	100-108	nitric oxide synthase, inducible	Mesocricetus auratus	8-12
19342207-0	2009	Pyridine induction of cytochrome P450 1A1, iNOS and metallothionein in Syrian hamsters and protective effects of silymarin.	pyridine	0-8	nitric oxide synthase, inducible	Mesocricetus auratus	43-47
19342207-8	2009	Silymarin application abolished or significantly suppressed the induction of CYP1A1, iNOS and MT expressions in liver, kidney and heart of the pyridine-treated Syrian hamsters.	pyridine	143-151	cytochrome P450 1A1	Mesocricetus auratus	77-83
19342207-8	2009	Silymarin application abolished or significantly suppressed the induction of CYP1A1, iNOS and MT expressions in liver, kidney and heart of the pyridine-treated Syrian hamsters.	pyridine	143-151	nitric oxide synthase, inducible	Mesocricetus auratus	85-89
19342207-11	2009	These results suggest that through oxidant generation, pyridine may cause alteration of the metabolic ways, including nitric oxide-mediated CYP1A1 activity.	pyridine	55-63	cytochrome P450 1A1	Mesocricetus auratus	140-146
19172312-4	2009	As such, in the gas phase, the relative reactivity exhibits the trend isomer B &gt; isomer A, while at the highest level, B2//B1 with zero point energy and solvation corrections, the relative reactivity follows the order isomer B &gt; isomer A &gt; isomer C. Thus, the calculated reaction pathway shows that pyridine rings perpendicular to the Fe-O axis result in more reactive species, and a pyridine ring coordinated trans to the oxygen atom leads to the least reactive isomer.	pyridine	308-316	immunoglobulin kappa variable 5-2	Homo sapiens	122-128
19172312-4	2009	As such, in the gas phase, the relative reactivity exhibits the trend isomer B &gt; isomer A, while at the highest level, B2//B1 with zero point energy and solvation corrections, the relative reactivity follows the order isomer B &gt; isomer A &gt; isomer C. Thus, the calculated reaction pathway shows that pyridine rings perpendicular to the Fe-O axis result in more reactive species, and a pyridine ring coordinated trans to the oxygen atom leads to the least reactive isomer.	pyridine	393-401	immunoglobulin kappa variable 5-2	Homo sapiens	122-128
19231828-9	2009	Irradiation of 26 ([Cr{eta(6)-C(6)H(5)CH(2)(2-Py)}(CO)(3)]) also induces CO loss to immediately yield three species: the Cr-heptane solvent coordinated intermediate, a kappaN(1)-Py nitrogen chelate, and an agostic eta(2)-chelate in which the pyridine is coordinated to the metal center via a C-H agostic bond as opposed to the nitrogen lone pair.	pyridine	242-250	endothelin receptor type A	Homo sapiens	23-26
19185294-4	2009	Here, we describe the efficient synthesis of PIA oligosaccharides using an acid reversion reaction of N-acetylglucosamine in HF.pyridine.	pyridine	128-136	RPTOR independent companion of MTOR complex 2	Homo sapiens	45-48
19673129-1	2009	We have studied the mechanical properties of films of a novel ionic discogen, pyridinium tethered with hexaalkoxytriphenylene (PyTp) and its complex with DNA (PyTp-DNA) using atomic force microscope (AFM).	pyridine	78-88	TTK protein kinase	Homo sapiens	127-131
19673129-1	2009	We have studied the mechanical properties of films of a novel ionic discogen, pyridinium tethered with hexaalkoxytriphenylene (PyTp) and its complex with DNA (PyTp-DNA) using atomic force microscope (AFM).	pyridine	78-88	TTK protein kinase	Homo sapiens	159-163
18586390-5	2009	The IR spectra of adsorbed pyridine showed that there were Lewis acid sites on the surface of this SnO(2) catalyst.	pyridine	27-35	strawberry notch homolog 1	Homo sapiens	99-102
19456290-2	2009	Pyridinium aldoximes are medically used to reactivate the cholinesterase enzymes inhibited by organophosphates.	pyridine	0-10	butyrylcholinesterase	Homo sapiens	58-72
19236035-1	2009	Azo-coupled macrocyclic chromoionophores incorporating benzene (L(1)) and pyridine (L(2)) subunits were synthesized, respectively.	pyridine	74-82	immunoglobulin kappa variable 3-15	Homo sapiens	84-88
19236035-3	2009	However, L(1) gave a larger cation-induced hypsochromic shift than L(2), suggesting that the presence of the pyridine unit in L(2) may inhibit the Hg...N-azo interaction.	pyridine	109-117	L1 cell adhesion molecule	Homo sapiens	9-13
19236035-3	2009	However, L(1) gave a larger cation-induced hypsochromic shift than L(2), suggesting that the presence of the pyridine unit in L(2) may inhibit the Hg...N-azo interaction.	pyridine	109-117	immunoglobulin kappa variable 3-15	Homo sapiens	67-71
19236035-3	2009	However, L(1) gave a larger cation-induced hypsochromic shift than L(2), suggesting that the presence of the pyridine unit in L(2) may inhibit the Hg...N-azo interaction.	pyridine	109-117	immunoglobulin kappa variable 3-15	Homo sapiens	126-130
19292551-3	2009	Values are calculated for the adsorption energies of butadiene, thiophene, benzothiophene, pyridine, quinoline, benzene, and naphthalene on the basal plane of MoS(2), showing good agreement with available experimental data, and the equilibrium geometry is found as flat at a separation of about 3.5 A for all studied molecules.	pyridine	91-99	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	159-162
19231828-9	2009	Irradiation of 26 ([Cr{eta(6)-C(6)H(5)CH(2)(2-Py)}(CO)(3)]) also induces CO loss to immediately yield three species: the Cr-heptane solvent coordinated intermediate, a kappaN(1)-Py nitrogen chelate, and an agostic eta(2)-chelate in which the pyridine is coordinated to the metal center via a C-H agostic bond as opposed to the nitrogen lone pair.	pyridine	242-250	endothelin receptor type A	Homo sapiens	214-217
19190378-3	2009	In (I), two independent Co(II) ions are six-coordinated through N(3)O(3) donor sets in slightly distorted octahedral geometries provided by two carboxylate and three pyridine ligands, and one water molecule.	pyridine	166-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
19133788-1	2009	We use quantum mechanics to elucidate the mechanism for the reaction of molecular oxygen with palladium-hydride complexes, (pyridine)(2)-Pd(II)(H)OAc, in toluene, focusing specifically on the direct insertion pathway of dioxygen into the Pd-H bond and pathways proceeding through a Pd(0) intermediate for both cis and trans starting configurations as well as with the assistance of an extra HOAc molecule We report the potential energy surfaces and structures for each of these pathways.	pyridine	123-133	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	238-242
19032108-2	2009	At low exposure the C 1s and N 1s core levels show a single adsorption state of pyridine with N 1s binding energy at 400.85 eV and C 1s binding energies at 286.7 and 285.9 eV, respectively.	pyridine	80-88	complement C1s	Homo sapiens	20-24
19032108-2	2009	At low exposure the C 1s and N 1s core levels show a single adsorption state of pyridine with N 1s binding energy at 400.85 eV and C 1s binding energies at 286.7 and 285.9 eV, respectively.	pyridine	80-88	complement C1s	Homo sapiens	131-135
19032108-3	2009	Those are attributable to Ge-N dative bonding of pyridine through the lone pair electrons of its N atom, which is consistent with previous STM and theoretical studies.	pyridine	49-57	sulfotransferase family 1A member 3	Homo sapiens	139-142
19068321-4	2008	Both the three-way PARAFAC and tri-PLS1 models successfully predicted the concentration of pyridine in synthetic (spiked) river water and field wastewater samples.	pyridine	91-99	plastin 1	Homo sapiens	35-39
19049427-0	2008	In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.	pyridine	114-122	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	15-35
18855374-0	2008	Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1).	pyridine	130-142	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	194-249
18975868-1	2008	Substitution of one pyridine by pyrazine in each DPA appendage of ZP1 leads to a new zinc sensor, ZPP1, with a modified background fluorescence and zinc affinity.	pyridine	20-28	zona pellucida glycoprotein 1	Mus musculus	66-69
21581180-0	2008	Carbon-yl(eta-cyclo-penta-dien-yl)(pyridine)(triethyl-stann-yl)iron(II).	pyridine	35-43	endothelin receptor type A	Homo sapiens	10-13
18707892-0	2008	Design and synthesis of carborane-containing androgen receptor (AR) antagonist bearing a pyridine ring.	pyridine	89-97	androgen receptor	Homo sapiens	45-62
18827937-5	2008	Ligand substitution in trans-[PtCl2(PhCN)(N=C(Ph)-O-N(Me)-CR1R2)] allows for selective replacement of the coordinated nitrile by nitrogen heterocycles such as pyridine, DMAP or 1-benzyl-2-methylimidazole to produce mixed ligand Pt(II) complexes of the type trans- [PtX2(heterocycle)(N=C(Ph)-O-N(Me)-CR1R2)].	pyridine	159-167	paired like homeodomain 2	Homo sapiens	265-269
18617161-3	2008	For the recovery of inhibited AChE, derivatives from the group of pyridinium or bispyridinium aldoximes (called oximes) are used.	pyridine	66-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-34
18707892-0	2008	Design and synthesis of carborane-containing androgen receptor (AR) antagonist bearing a pyridine ring.	pyridine	89-97	androgen receptor	Homo sapiens	64-66
18707892-2	2008	As an extension of that work, we designed and synthesized carborane-containing AR antagonist candidates with a pyridine ring.	pyridine	111-119	androgen receptor	Homo sapiens	79-81
18707892-3	2008	Compound 6b, which has a pyridine ring directly bound to the p-carborane cage at the 3-position, exhibited potent AR-antagonistic activity in transcriptional activation assay using NIH3T3 cells transfected with a hAR-expression plasmid.	pyridine	25-33	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	114-116
18605691-2	2008	The reaction of p-phenylenediamine with excess PCl 3 in the presence of pyridine affords p-C 6H 4[N(PCl 2) 2] 2 ( 1) in good yield.	pyridine	72-80	PHD finger protein 19	Homo sapiens	47-52
18680255-2	2008	Addition of pyridine to 1 gives in high yield the 11-vertex nido-hydridorhodathiaborane [8,8,8-(PPh 3) 2H-9-(NC 5H 5)- nido-8,7-RhSB 9H 9] ( 2).	pyridine	12-20	protein phosphatase 4 catalytic subunit	Homo sapiens	96-101
18605691-2	2008	The reaction of p-phenylenediamine with excess PCl 3 in the presence of pyridine affords p-C 6H 4[N(PCl 2) 2] 2 ( 1) in good yield.	pyridine	72-80	metal response element binding transcription factor 2	Homo sapiens	100-105
18850845-1	2008	We have studied the electrical conductivity in monolayer films of an ionic disk-shaped liquid-crystal molecule, pyridinium tethered with hexaalkoxytriphenylene (PyTp), and its complex with DNA by current-sensing atomic force microscopy (CS-AFM).	pyridine	112-122	TTK protein kinase	Homo sapiens	161-165
18510286-4	2008	Substitution of the PF 6 (-) anion for Br (-) leads to the clean formation of [Re(CO) 3L 3][PF 6] ([ 3][PF 6]-[ 5][PF 6]) for py, N-MeIm, and tht, respectively, as the only products observed.	pyridine	126-128	sperm associated antigen 17	Homo sapiens	20-24
18600270-6	2008	The X-ray crystal structure of the CA II-indapamide adduct was also resolved at high resolution, and the binding of this sulfonamide to the enzyme was compared to that of dichlorophenamide, sulpiride and a pyridinium containing sulfonamide.	pyridine	206-216	carbonic anhydrase 2	Homo sapiens	35-40
18510286-4	2008	Substitution of the PF 6 (-) anion for Br (-) leads to the clean formation of [Re(CO) 3L 3][PF 6] ([ 3][PF 6]-[ 5][PF 6]) for py, N-MeIm, and tht, respectively, as the only products observed.	pyridine	126-128	sperm associated antigen 17	Homo sapiens	92-96
18510286-4	2008	Substitution of the PF 6 (-) anion for Br (-) leads to the clean formation of [Re(CO) 3L 3][PF 6] ([ 3][PF 6]-[ 5][PF 6]) for py, N-MeIm, and tht, respectively, as the only products observed.	pyridine	126-128	sperm associated antigen 17	Homo sapiens	92-96
18510286-4	2008	Substitution of the PF 6 (-) anion for Br (-) leads to the clean formation of [Re(CO) 3L 3][PF 6] ([ 3][PF 6]-[ 5][PF 6]) for py, N-MeIm, and tht, respectively, as the only products observed.	pyridine	126-128	sperm associated antigen 17	Homo sapiens	92-96
18386923-3	2008	X-ray diffraction studies on the crystalline complex salt of formula [CoII(1)...H2O]Cl(PF6)(4).2MeCN have shown that a water molecule is included in the cavity and the water oxygen atom receives six H-bonds from the C-H fragments of the three imidazolium subunits and of the three proximate pyridine rings, according to a slightly distorted trigonal prismatic geometry.	pyridine	291-299	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
18478140-0	2008	Maleate-fumarate conversion and other novel aspects of the reaction of a Co(II) maleate with pyridine and bipyridine.	pyridine	93-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
18800711-3	2008	By using Pyridine as the probe molecules, SERS studies were performed.	pyridine	9-17	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	42-46
18411844-4	2008	The N,S-heterodisubstituted o-carborane containing a mercapto group, 1-(2"-pyridyl)-2-SH-1,2-closo-C2B10H10, 1, is one of the two examples of a rigid bidentate chelating (pyridine)N-C-C-C-S(H) motif having been structurally fully characterized.	pyridine	171-179	secretoglobin family 2B member 3, pseudogene	Homo sapiens	99-110
21202475-1	2008	In the title complex, [CoCl(2)(C(21)H(19)N(3))], the Co(II) atom is coordinated by one pyridine and two imine N atoms and by two chloride anions in a distorted trigonal bipyramidal geometry.	pyridine	87-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
18054895-3	2008	In the present study, we investigated whether SK-126, a pyridine derivative based on gentianine originated from a natural product, can affect the LPS-induced inflammatory cytokine production in DC.	pyridine	56-64	toll-like receptor 4	Mus musculus	146-149
18262416-3	2008	Investigation of replacements for the methylene linker uncovered disparate SAR in the thiazole and pyridine series.	pyridine	99-107	sarcosine dehydrogenase	Homo sapiens	75-78
18251509-1	2008	Pyridine is a prototypical inducer of cytochrome P450 (CYP) 2E1, an enzyme associated with cellular oxidative stress and membrane damage.	pyridine	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	38-63
18317233-0	2008	Evidence of increased bone resorption in neurofibromatosis type 1 using urinary pyridinium crosslink analysis.	pyridine	80-90	neurofibromin 1	Homo sapiens	41-65
18317233-7	2008	NF1 children have an increase in the urinary excretion of pyridinium crosslinks, reflecting increased bone resorption.	pyridine	58-68	neurofibromin 1	Homo sapiens	0-3
18241201-1	2008	BVR-B (biliverdin-IXbeta reductase) also known as FR (flavin reductase) is a promiscuous enzyme catalysing the pyridine-nucleotide-dependent reduction of a variety of flavins, biliverdins, PQQ (pyrroloquinoline quinone) and ferric ion.	pyridine	111-119	biliverdin reductase B	Homo sapiens	0-5
18241201-1	2008	BVR-B (biliverdin-IXbeta reductase) also known as FR (flavin reductase) is a promiscuous enzyme catalysing the pyridine-nucleotide-dependent reduction of a variety of flavins, biliverdins, PQQ (pyrroloquinoline quinone) and ferric ion.	pyridine	111-119	biliverdin reductase B	Homo sapiens	7-34
18298058-2	2008	1 was further reacted with a monodentate ligand (pyridine) to yield a fac-Re(acac)(pyridine)(CO)3 complex (2).	pyridine	49-57	FA complementation group C	Homo sapiens	70-73
18712740-3	2008	They exhibit drastic structural changes on heating and photoirradiation at their MLCT bands, which involve partial dissociation of the tetradentate TPA ligand to exhibit a facially tridentate mode accompanied by structural change and solvent coordination to give [Ru(TPA)(diimine)(solvent)]2+ (solvent=acetonitrile, pyridine).	pyridine	316-324	plasminogen activator, tissue type	Homo sapiens	148-151
18270986-5	2008	Decisive step of the whole sequence was the macrocyclization to a 29-membered macrolactam, which was conducted as an intramolecular Stille cross-coupling occurring at C-2 of the pyridine core and providing the desired product in 75 % yield.	pyridine	178-186	complement C2	Homo sapiens	167-170
17964172-3	2008	Structure-activity relationship study of the binding with the overexpressed human CYP51 indicates that the pyridine binds within the heme binding pocket in an analogy with the azoles.	pyridine	107-115	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	82-87
18418837-4	2008	The reaction of six-membered-ring fused 2,3-disubstituted 1,4-dilithio-1,3-diene (Type III) with 2-cyanopyridine afforded the corresponding pyridine, and no tricyclic Delta1-bipyrroline was observed.	pyridine	104-112	delta like non-canonical Notch ligand 1	Homo sapiens	167-173
18712740-3	2008	They exhibit drastic structural changes on heating and photoirradiation at their MLCT bands, which involve partial dissociation of the tetradentate TPA ligand to exhibit a facially tridentate mode accompanied by structural change and solvent coordination to give [Ru(TPA)(diimine)(solvent)]2+ (solvent=acetonitrile, pyridine).	pyridine	316-324	plasminogen activator, tissue type	Homo sapiens	267-270
18004874-10	2007	Subsequent treatment with sodium hydroxide releases a modified coenzyme consisting of a vinylglyoxylic acid moiety linked through C-4" to the 4-position of the pyridine ring.	pyridine	160-168	complement C4A (Rodgers blood group)	Homo sapiens	130-133
17929796-2	2007	Structure-activity relationship studies of these novel nAChR ligands focused on substitution effects on the pyridine ring, as well as stereo- and regiochemical influences of the 3,6-diazabicyclo[3.2.0]heptane core.	pyridine	108-116	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	55-60
17973283-5	2007	Ru/CNF-P was also effective for the hydrogenation of functionalized benzene derivatives and pyridine.	pyridine	92-100	NPHS1 adhesion molecule, nephrin	Homo sapiens	3-6
17299451-0	2007	Evaluation of four pyridine analogs to characterize 6-OHDA-induced modulation of mGluR5 function in rat brain using microPET studies.	pyridine	19-27	glutamate receptor, ionotropic, kainate 1	Mus musculus	81-87
17685602-4	2007	Elaborations involving substitutions of the 2 and 4 positions of the pyrimidine or pyridine ring and the 6 and 7 positions of the central pyrazine ring resulted in in vivo activity profiles which identified potent inhibitors of vascular endothelial growth factor (VEGF) induced vascular leakage.	pyridine	83-91	vascular endothelial growth factor A	Homo sapiens	228-262
17630681-1	2007	The 1H NMR spectra of a series of mono- and dinuclear pyridine complexes [FeL1(R1/R2)(py)2] and [Fe2L2(R1/R2)(py)4] have been investigated in a mixed toluene-d8/pyridine-d5 solution.	pyridine	54-62	CD1b molecule	Homo sapiens	79-84
17960099-2	2007	This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used AChE reactivators.	pyridine	112-122	acetylcholinesterase (Cartwright blood group)	Homo sapiens	31-51
17960099-2	2007	This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used AChE reactivators.	pyridine	112-122	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-57
18019535-0	2007	Design, synthesis and biological evaluation of thrombin inhibitors based on a pyridine scaffold.	pyridine	78-86	coagulation factor II, thrombin	Homo sapiens	47-55
18019535-2	2007	A Grignard exchange reaction was used to introduce various benzoyl substituents in position 4 of the pyridine ring, where they serve as P3 residues in binding to thrombin.	pyridine	101-109	coagulation factor II, thrombin	Homo sapiens	162-170
17574850-0	2007	Himbacine derived thrombin receptor (PAR-1) antagonists: SAR of the pyridine ring.	pyridine	68-76	coagulation factor II thrombin receptor	Homo sapiens	37-42
17960095-1	2007	A series of novel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles.	pyridine	65-71	indoleamine 2,3-dioxygenase 2	Homo sapiens	21-28
17960095-1	2007	A series of novel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles.	pyridine	65-71	PROP paired-like homeobox 1	Homo sapiens	32-38
17441770-5	2007	The pyridine-substituted TTF compounds 6-8 show remarkable sensing and coordinating properties toward Pb2+.	pyridine	4-12	ras homolog family member H	Homo sapiens	25-28
17585748-3	2007	Structure-activity studies have revealed that substitutions, particularly hydrophilic groups in the pyridine 5-position, differentially modulate the agonist activity at ganglionic vs central nAChR subtypes, so that improved subtype selectivity can be demonstrated in vitro.	pyridine	100-108	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	191-196
17482821-4	2007	The most distinct and selective antiviral activity toward coxsackieviruses and echoviruses was observed with compounds having pyridine ring at C-2.	pyridine	126-134	complement C2	Homo sapiens	143-146
17433522-7	2007	Induction of CYP2E1 with pyridine also markedly increased sensitivity of hepatocytes to Tri but had little effect on Perc-induced cytotoxicity.	pyridine	25-33	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	13-19
17763786-8	2007	The addition of DNA causes the SERS signals of the complex to weaken and the band at 1 282 cm(-1) to disappear, which suggests that the planar pyridine molecule of the ligand may partly be inserted into the double-stranded helix plane in DNA, making pi electronic density of aromatic rings in complex change.	pyridine	143-151	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	31-35
17461574-1	2007	Two new polynuclear azido-bridged Co(II) compounds with formulas catena-[Co(mu1,3-N3)(N3)(py)2(H2O)]n (1) and [Co(mu1,3-N3)2(4-acpy)2]n (2) (py=pyridine, 4-acpy=4-acetylpyridine) have been structurally and magnetically characterized.	pyridine	144-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
17388551-18	2007	The pyridine ring of the PLP aldimines is not protonated in aqueous solution near neutral pH.	pyridine	4-12	pyridoxal phosphatase	Homo sapiens	25-28
17395218-7	2007	Furthermore, cells cultured in the presence of the mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) show reduced N-methyl-D-aspartate (NMDA) receptor-mediated Ca2+ mobilisation but increased alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor Ca2+ permeability.	pyridine	94-103	glutamate receptor, ionotropic, kainate 1	Mus musculus	51-57
17350268-3	2007	Among them, a compound (13) possessing a nitrogen at the delta-position of the pyridine ring (delta-N type) showed the most potent affinity for adenosine receptor A(3) subtype, while N-methylation (14) of a pyrrole ring in 13 significantly lowered the potency as adenosine receptor ligands.	pyridine	79-87	adenosine A3 receptor	Homo sapiens	144-167
17391033-3	2007	In laser flash photolysis (LFP) experiments, CCl2 forms chromophoric ylides or oxides with pyridine, 2-picoline, thioanisole, and oxygen.	pyridine	91-99	C-C motif chemokine ligand 2	Homo sapiens	45-49
17253762-4	2007	The hydrogen bonding between the pyridine nitrogen and the hydroxyl groups of HEMA results in strong intrachain associations, prevents interactions between NREP and CA, and inhibits degradation of CA.	pyridine	33-41	neuronal regeneration related protein	Homo sapiens	156-160
17326626-2	2007	The reaction in pyridine or DMF of this ligand with various M(AcO)2 salts (M = NiII, CoII, MnII) leads to very different products depending on the metal.	pyridine	16-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
17275313-1	2007	Schiff bases prepared by the reactions of substituted amines with indole-/, pyrimidine-/, pyridine-/, and quinoline-aldehydes are made to undergo indium mediated allylation whereby a (substituted amine, allyl)methyl group has been introduced at C-3 of indole, C-5 of pyrimidine, and C-2 of pyridine and quinoline.	pyridine	90-98	complement C3	Homo sapiens	245-248
17275313-1	2007	Schiff bases prepared by the reactions of substituted amines with indole-/, pyrimidine-/, pyridine-/, and quinoline-aldehydes are made to undergo indium mediated allylation whereby a (substituted amine, allyl)methyl group has been introduced at C-3 of indole, C-5 of pyrimidine, and C-2 of pyridine and quinoline.	pyridine	90-98	complement C5	Homo sapiens	260-263
17275313-1	2007	Schiff bases prepared by the reactions of substituted amines with indole-/, pyrimidine-/, pyridine-/, and quinoline-aldehydes are made to undergo indium mediated allylation whereby a (substituted amine, allyl)methyl group has been introduced at C-3 of indole, C-5 of pyrimidine, and C-2 of pyridine and quinoline.	pyridine	90-98	complement C2	Homo sapiens	283-286
17275313-1	2007	Schiff bases prepared by the reactions of substituted amines with indole-/, pyrimidine-/, pyridine-/, and quinoline-aldehydes are made to undergo indium mediated allylation whereby a (substituted amine, allyl)methyl group has been introduced at C-3 of indole, C-5 of pyrimidine, and C-2 of pyridine and quinoline.	pyridine	290-298	complement C3	Homo sapiens	245-248
17275313-1	2007	Schiff bases prepared by the reactions of substituted amines with indole-/, pyrimidine-/, pyridine-/, and quinoline-aldehydes are made to undergo indium mediated allylation whereby a (substituted amine, allyl)methyl group has been introduced at C-3 of indole, C-5 of pyrimidine, and C-2 of pyridine and quinoline.	pyridine	290-298	complement C5	Homo sapiens	260-263
17275313-1	2007	Schiff bases prepared by the reactions of substituted amines with indole-/, pyrimidine-/, pyridine-/, and quinoline-aldehydes are made to undergo indium mediated allylation whereby a (substituted amine, allyl)methyl group has been introduced at C-3 of indole, C-5 of pyrimidine, and C-2 of pyridine and quinoline.	pyridine	290-298	complement C2	Homo sapiens	283-286
17048265-0	2007	1H, 13C and 15N NMR coordination shifts in gold(III), cobalt(III), rhodium(III) chloride complexes with pyridine, 2,2"-bipyridine and 1,10-phenanthroline.	pyridine	104-112	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	48-51
17212421-0	2007	Isomerization dynamics and control of the eta2/N equilibrium for pyridine complexes.	pyridine	65-73	DNA polymerase iota	Homo sapiens	42-46
17212421-2	2007	Depending on substitution pattern, the pyridine can be either N- or eta2-coordinated, and the role of the pyridine substituents and metal oxidation state in determining this equilibrium is explored.	pyridine	39-47	DNA polymerase iota	Homo sapiens	68-72
17226941-4	2007	The azine- and biphenyl-based beloamphiphiles (Y-Ph-MeC=N-N=CMe-Ph-X and Y-Ph-Ph-X) are ascendants of a new generation of highly anisotropic functional materials with perfect polar order.	pyridine	4-9	C-C motif chemokine ligand 28	Homo sapiens	52-55
17219454-2	2007	EPR spectroscopy, X-ray diffraction, and DFT calculations reveal that each of these [M(II)(cod)(N-ligand)](2+) species adopts a square-pyramidal geometry with the two cod double bonds and the two pyridine fragments in the basal plane and the N(amine) donor at the apical position.	pyridine	196-204	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	91-94
17160181-5	2007	The reaction of [PtCl(BCl2)(PMe3)2] with NEt3 or pyridine (py) affords the adducts [PtCl{BCl2(NEt3)}(PMe3)2] and [PtCl{BCl2(py)}(PMe3)2], respectively, both characterised spectroscopically.	pyridine	49-57	BCL2 apoptosis regulator	Homo sapiens	22-26
17160181-5	2007	The reaction of [PtCl(BCl2)(PMe3)2] with NEt3 or pyridine (py) affords the adducts [PtCl{BCl2(NEt3)}(PMe3)2] and [PtCl{BCl2(py)}(PMe3)2], respectively, both characterised spectroscopically.	pyridine	49-57	BCL2 apoptosis regulator	Homo sapiens	89-93
17160181-5	2007	The reaction of [PtCl(BCl2)(PMe3)2] with NEt3 or pyridine (py) affords the adducts [PtCl{BCl2(NEt3)}(PMe3)2] and [PtCl{BCl2(py)}(PMe3)2], respectively, both characterised spectroscopically.	pyridine	49-57	tetraspanin 2	Homo sapiens	94-98
17160181-5	2007	The reaction of [PtCl(BCl2)(PMe3)2] with NEt3 or pyridine (py) affords the adducts [PtCl{BCl2(NEt3)}(PMe3)2] and [PtCl{BCl2(py)}(PMe3)2], respectively, both characterised spectroscopically.	pyridine	49-57	BCL2 apoptosis regulator	Homo sapiens	89-93
17328439-8	2007	The VRE and ASE values suggest that pyridine is more strongly stabilized by aromatic conjugation than benzene.	pyridine	36-44	arylsulfatase L	Homo sapiens	12-15
17048265-0	2007	1H, 13C and 15N NMR coordination shifts in gold(III), cobalt(III), rhodium(III) chloride complexes with pyridine, 2,2"-bipyridine and 1,10-phenanthroline.	pyridine	104-112	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	61-64
17048265-0	2007	1H, 13C and 15N NMR coordination shifts in gold(III), cobalt(III), rhodium(III) chloride complexes with pyridine, 2,2"-bipyridine and 1,10-phenanthroline.	pyridine	104-112	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	61-64
17181212-8	2006	As a preliminary example for extended application, the pyridine adsorption configuration at an as-deposited Ag electrode was re-examined by ATR-SEIRAS.	pyridine	55-63	ATR serine/threonine kinase	Homo sapiens	140-143
17181212-9	2006	The results revealed that pyridine molecules are bound via N end to the Ag electrode with its ring plane perpendicular or slightly tilted to the local surface without rotating its C2 axis about the surface normal, consistent with the conclusion drawn by SERS in the literature.	pyridine	26-34	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	254-258
17165790-2	2006	The present study shows that the enhancement of carbon acidity of alpha-amino acids by the cofactor pyridoxal 5"-phosphate (PLP) with an unusual, unprotonated pyridine is mainly due to solvation effects, in contrast to the intrinsic electron-withdrawing stabilization by the pyridinium ion to form a quinonoid intermediate.	pyridine	159-167	pyridoxal phosphatase	Homo sapiens	124-127
17173447-4	2006	The pKa* values of the pyridine nitrogens of the ligands are low (azpy 2.47, azpy-OH 3.06 and azpy-NMe2 4.60), suggesting that they are weak sigma-donors.	pyridine	23-31	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	99-103
17165790-2	2006	The present study shows that the enhancement of carbon acidity of alpha-amino acids by the cofactor pyridoxal 5"-phosphate (PLP) with an unusual, unprotonated pyridine is mainly due to solvation effects, in contrast to the intrinsic electron-withdrawing stabilization by the pyridinium ion to form a quinonoid intermediate.	pyridine	275-285	pyridoxal phosphatase	Homo sapiens	124-127
17083911-6	2006	Hence this novel electrophoretic method allows the easy detection of NADK, a critical enzyme involved in pyridine homeostasis.	pyridine	105-113	NAD kinase	Homo sapiens	69-73
17100424-2	2006	Nevertheless, recent studies have shown that approximate exchange-correlation energy density functionals can incorrectly predict the stability order of spin states in, for instance, iron-containing pyridine and imidazole systems.	pyridine	198-206	spindlin 1	Homo sapiens	152-156
16919961-5	2006	We demonstrate how the increase in the number of the atoms connecting the pyrrolidine and pyridine rings in A-84543, 1, and 2, and an introduction of the alkynyl substituent in the pyridine ring affect the binding and shift the selectivity of these ligands toward the beta2-containing receptors.	pyridine	90-98	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	268-273
16919961-5	2006	We demonstrate how the increase in the number of the atoms connecting the pyrrolidine and pyridine rings in A-84543, 1, and 2, and an introduction of the alkynyl substituent in the pyridine ring affect the binding and shift the selectivity of these ligands toward the beta2-containing receptors.	pyridine	181-189	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	268-273
16985099-2	2006	For instance, the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to the neurotoxic pyridinium ion metabolite 1-methyl-4-phenylpyridinium by monoamine oxidase (MAO) B in the brain has been of interest to a number of investigators.	pyridine	94-104	monoamine oxidase B	Homo sapiens	151-176
16908149-0	2006	Design and synthesis of substituted pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors.	pyridine	36-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
16908149-2	2006	Pyridine carboxyamide derivatives bearing a substituted aryl group at the 5-position of the pyridine ring show appreciable activity, while constraining the side chain by placing a pyrazole carboxylic acid generated a potent lead series with consistent activity against EGLN-1.	pyridine	92-100	egl-9 family hypoxia inducible factor 1	Homo sapiens	269-275
16919454-0	2006	An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors.	pyridine	21-29	prolyl endopeptidase	Homo sapiens	58-79
16933918-0	2006	Chemistry of HIV-1 virucidal Pt complexes having neglected bidentate sp2 N-donor carrier ligands with linked triazine and pyridine rings.	pyridine	122-130	Sp2 transcription factor	Homo sapiens	69-72
17220062-6	2006	With regard to bone resorption and remodeling markers, the urinary excretion of pyridinium crosslinks was higher in patients with thalassemia for HP fraction (p &lt; 0.0005) and LP fraction (p = 0.002), as well as TGFbeta (p = 0.001).	pyridine	80-90	transforming growth factor beta 1	Homo sapiens	214-221
16824760-2	2006	The effect of the lactone carbonyl group on binding to PAR-1 is dependent on the substitution pattern of the pyridine ring.	pyridine	109-117	coagulation factor II thrombin receptor	Homo sapiens	55-60
16828550-1	2006	New bis-pyridinium oxime reactivators connected with CH2O(CH2)n OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent.	pyridine	8-18	acetylcholinesterase (Cartwright blood group)	Homo sapiens	186-190
16958540-5	2006	The [2 + 3] hemicapsules H2A3 built with sulfate linkers incorporate guests between the closely positioned pyridinium planes.	pyridine	107-117	H2A clustered histone 7	Homo sapiens	25-29
17117687-5	2006	The chemoselective addition of a 4-N-tertbutyl-chloropiperidine Grignard reagent to a pyridine oxide intermediate followed by re-aromatization using isobutylchloroformate and pyridine as solvent completed the synthesis of this potentially important p38 kinase inhibitor.	pyridine	86-94	mitogen-activated protein kinase 14	Homo sapiens	249-252
17076898-0	2006	ADDP and PS-PPh3: an efficient Mitsunobu protocol for the preparation of pyridine ether PPAR agonists.	pyridine	73-81	caveolin 1	Homo sapiens	12-16
17076898-0	2006	ADDP and PS-PPh3: an efficient Mitsunobu protocol for the preparation of pyridine ether PPAR agonists.	pyridine	73-81	peroxisome proliferator activated receptor alpha	Homo sapiens	88-92
17076898-1	2006	A series of pyridine ether PPAR agonists were synthesized through an ADDP and PS-PPh3 modified Mitsunobu protocol, which eliminated significant by-product formation.	pyridine	12-20	peroxisome proliferator activated receptor alpha	Homo sapiens	27-31
17076898-1	2006	A series of pyridine ether PPAR agonists were synthesized through an ADDP and PS-PPh3 modified Mitsunobu protocol, which eliminated significant by-product formation.	pyridine	12-20	caveolin 1	Homo sapiens	81-85
17020376-2	2006	Cytochrome c was coordinatively bound to self-assembled monolayers of pyridine-terminated alkanethiols on Au and Ag electrodes.	pyridine	70-78	cytochrome c, somatic	Homo sapiens	0-12
16928044-4	2006	Finally, the FG-ring was constructed by HF.pyridine to accomplish the synthesis of the suitably protected C21-C40 fragment.	pyridine	43-51	TBL1X/Y related 1	Homo sapiens	106-109
16797985-3	2006	Finally, synthesis and biological evaluation of pyridine analogues have shown the benefical effect of the pyridine ring on the PPARbeta/delta subtype selectivity.	pyridine	48-56	peroxisome proliferator activated receptor delta	Homo sapiens	127-135
16797985-3	2006	Finally, synthesis and biological evaluation of pyridine analogues have shown the benefical effect of the pyridine ring on the PPARbeta/delta subtype selectivity.	pyridine	106-114	peroxisome proliferator activated receptor delta	Homo sapiens	127-135
16928044-4	2006	Finally, the FG-ring was constructed by HF.pyridine to accomplish the synthesis of the suitably protected C21-C40 fragment.	pyridine	43-51	CCR4-NOT transcription complex subunit 11	Homo sapiens	110-113
16878961-8	2006	The tertiary amine groups in ZAP1-3 are less basic than those in ZP1, which implies that the additional pyridine rings are responsible for the emissive response to Zn2+ at pH 7.0.	pyridine	104-112	zinc finger protein 569	Homo sapiens	29-33
16834369-6	2006	The cyclooctene allyl-alkyl compound (5C) can be converted to an eta2-diene complex by heating with pyridine.	pyridine	100-108	DNA polymerase iota	Homo sapiens	65-69
16631211-3	2006	The GluR1-4 affinities of 3 were similar to 1, however, its 31-fold selectivity for GluR1/2 over GluR3/4 is the highest yet observed among azine-based glutamate analogues.	pyridine	139-144	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	84-91
16678413-2	2006	Modifications at the 3 position of the pyridine ring led to a number of potent compounds with improved physical properties, resulting in the identification of 11g as a promising, orally active Akt inhibitor.	pyridine	39-47	AKT serine/threonine kinase 1	Homo sapiens	193-196
16628761-7	2006	Reaction of (S,S)-10 b and pyridine affords (S)-[(eta5-C5H4)Re(NO)(PPh3)(mu-CH2PPh2)Pd(NC5H5)(Br)] ((S)-17 b, 72 %); other Lewis bases yield similar adducts.	pyridine	27-35	protein phosphatase 4 catalytic subunit	Homo sapiens	67-71
16631211-3	2006	The GluR1-4 affinities of 3 were similar to 1, however, its 31-fold selectivity for GluR1/2 over GluR3/4 is the highest yet observed among azine-based glutamate analogues.	pyridine	139-144	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	4-9
16631211-3	2006	The GluR1-4 affinities of 3 were similar to 1, however, its 31-fold selectivity for GluR1/2 over GluR3/4 is the highest yet observed among azine-based glutamate analogues.	pyridine	139-144	glutamate ionotropic receptor AMPA type subunit 3	Rattus norvegicus	97-102
16787057-2	2006	The present studies show that enhancement of carbon acidity of alpha-amino acids by cofactor pyridoxal 5"-phosphate, PLP, with an unusual, unprotonated pyridine is due to solvation effects, in contrast to the intrinsic electron-withdrawing stabilization by the pyridinium ion to form a quinonoid intermediate.	pyridine	261-271	proteolipid protein 1	Homo sapiens	117-120
16466923-0	2006	Design, synthesis, and evaluation of new type of L-amino acids containing pyridine moiety as nitric oxide synthase inhibitor.	pyridine	74-82	nitric oxide synthase 2	Homo sapiens	93-114
16800507-0	2006	Role of conformation in the electronic properties of chemisorbed pyridine on Cu(110): an STM/STS study.	pyridine	65-73	sulfotransferase family 1A member 3	Homo sapiens	89-92
16800507-1	2006	Pyridine was chemisorbed on Cu(110) at 10 K and observed using STM at 5 K as dosed and after annealing to temperatures between 20 and 300 K. At very low coverage, two molecular species with different apparent heights are observed to coexist.	pyridine	0-8	sulfotransferase family 1A member 3	Homo sapiens	63-66
16683817-1	2006	Reaction of the dimeric species [(eta3-Ind)Pd(mu-Cl)]2 (1) (Ind = indenyl) with NEt3 gives the complex (eta(3-5)-Ind)Pd(NEt3)Cl (3), whereas the analogous reactions with BnNH2 (Bn = PhCH2) or pyridine (py) afford the complexes trans-L2Pd(eta1-Ind)Cl (L = BnNH2 (4), py (5)).	pyridine	192-200	tetraspanin 2	Homo sapiens	80-84
16683817-1	2006	Reaction of the dimeric species [(eta3-Ind)Pd(mu-Cl)]2 (1) (Ind = indenyl) with NEt3 gives the complex (eta(3-5)-Ind)Pd(NEt3)Cl (3), whereas the analogous reactions with BnNH2 (Bn = PhCH2) or pyridine (py) afford the complexes trans-L2Pd(eta1-Ind)Cl (L = BnNH2 (4), py (5)).	pyridine	192-200	tetraspanin 2	Homo sapiens	120-124
16683817-1	2006	Reaction of the dimeric species [(eta3-Ind)Pd(mu-Cl)]2 (1) (Ind = indenyl) with NEt3 gives the complex (eta(3-5)-Ind)Pd(NEt3)Cl (3), whereas the analogous reactions with BnNH2 (Bn = PhCH2) or pyridine (py) afford the complexes trans-L2Pd(eta1-Ind)Cl (L = BnNH2 (4), py (5)).	pyridine	192-194	tetraspanin 2	Homo sapiens	80-84
16683817-1	2006	Reaction of the dimeric species [(eta3-Ind)Pd(mu-Cl)]2 (1) (Ind = indenyl) with NEt3 gives the complex (eta(3-5)-Ind)Pd(NEt3)Cl (3), whereas the analogous reactions with BnNH2 (Bn = PhCH2) or pyridine (py) afford the complexes trans-L2Pd(eta1-Ind)Cl (L = BnNH2 (4), py (5)).	pyridine	192-194	tetraspanin 2	Homo sapiens	120-124
16683817-1	2006	Reaction of the dimeric species [(eta3-Ind)Pd(mu-Cl)]2 (1) (Ind = indenyl) with NEt3 gives the complex (eta(3-5)-Ind)Pd(NEt3)Cl (3), whereas the analogous reactions with BnNH2 (Bn = PhCH2) or pyridine (py) afford the complexes trans-L2Pd(eta1-Ind)Cl (L = BnNH2 (4), py (5)).	pyridine	202-204	tetraspanin 2	Homo sapiens	80-84
16683817-1	2006	Reaction of the dimeric species [(eta3-Ind)Pd(mu-Cl)]2 (1) (Ind = indenyl) with NEt3 gives the complex (eta(3-5)-Ind)Pd(NEt3)Cl (3), whereas the analogous reactions with BnNH2 (Bn = PhCH2) or pyridine (py) afford the complexes trans-L2Pd(eta1-Ind)Cl (L = BnNH2 (4), py (5)).	pyridine	202-204	tetraspanin 2	Homo sapiens	120-124
16441152-3	2006	The mechanistic investigation suggested that isomerization of cis-1 into trans-1 promoted by the combined use of C6H6 as a solvent and pyridine as a base was the key to the successful preparation of 1.	pyridine	135-143	suppressor of cytokine signaling 1	Homo sapiens	62-67
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	pyridine	64-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	pyridine	64-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
16307862-5	2006	The major metabolite was formed by hydroxylation of the pyridine ring (CL(int)=27 microl/mgmin), and was catalysed by both CYP2D6*1 and CYP1A1, with K(m) values corresponding to 1.4 and 2.7 microM, respectively.	pyridine	56-64	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	123-129
16307862-5	2006	The major metabolite was formed by hydroxylation of the pyridine ring (CL(int)=27 microl/mgmin), and was catalysed by both CYP2D6*1 and CYP1A1, with K(m) values corresponding to 1.4 and 2.7 microM, respectively.	pyridine	56-64	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	136-142
16529929-2	2006	Removal of the 3-amino group and incorporation of basic 5-piperazinyl carboxamides at the pyridine 5-position provided compounds with high affinity for the human B(1) receptor.	pyridine	90-98	bradykinin receptor B1	Homo sapiens	162-175
16481169-6	2006	Among all the compounds, tested the compound with the hexylene bridge (6b) and a 3-carbamoyl group on the second pyridine ring was found to be the most active acetylcholinesterase reactivator (72%) which is greater than that of 2-PAM (56%).	pyridine	113-121	peptidylglycine alpha-amidating monooxygenase	Mus musculus	230-233
16518048-1	2006	The title compound, C6H9BrN2O6P2, a micromolar inhibitor of the farnesyl pyrophosphate synthase, is a Z-isomer zwitterion with one negative phosphonate group and a protonated pyridine N atom.	pyridine	175-183	farnesyl diphosphate synthase	Homo sapiens	64-95
16332435-1	2006	The discovery of a novel, achiral pyridine class of potent and orally active neurokinin-1 (NK(1)) receptor antagonists is described.	pyridine	34-42	tachykinin receptor 1	Homo sapiens	77-106
16456276-4	2006	The coordination octahedron around each CoII ion is completed by three pyridine molecules for the two outer CoII ions and by two for the inner ion.	pyridine	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
16456276-4	2006	The coordination octahedron around each CoII ion is completed by three pyridine molecules for the two outer CoII ions and by two for the inner ion.	pyridine	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-112
16816928-11	2006	XX and PP ERalpha genotypes were associated (P &lt; 0.05) with reduced levels of urinary pyridinium cross-links, whereas serum osteocalcin was similar among genotypes.	pyridine	89-99	estrogen receptor 1	Homo sapiens	10-17
16955749-1	2006	Quantitative structure-activity relationship (QSAR) has been established on a series of thirty-eight compounds of four different sets of condensed pyridine and pyrimidine analogs, for their hydroxymethyl glutaryl coenzyme (HMG-CoA) reductase inhibitor activity, in order to understand the essential structural requirement for binding with receptor, in terms of common biophoric and secondary sites employing APEX-3D software.	pyridine	147-155	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	184-241
16198581-0	2006	Search for dual function inhibitors for Alzheimer"s disease: synthesis and biological activity of acetylcholinesterase inhibitors of pyridinium-type and their Abeta fibril formation inhibition capacity.	pyridine	133-143	acetylcholinesterase (Cartwright blood group)	Homo sapiens	98-118
16198581-4	2006	[Scarpini, E.; Scheltens, P.; Feldman, H. Lancet Neurol.2003, 2, 539] In view of the development of new AChE inhibitors as drugs capable of reducing the symptoms of AD, the capacity of newly synthesized AChE inhibitors of pyridinium-type to inhibit the AChE was examined and compared to those of other inhibitors of this type presented earlier.	pyridine	222-232	acetylcholinesterase (Cartwright blood group)	Homo sapiens	104-108
16198581-10	2006	Pharmacol.2003, 55, 1397] Furthermore, the anti-Abeta fibril formation property of AChE inhibitors of pyridinium- and bispyridinium-type was evaluated to expand their activity profile and to reveal potential additive pharmacological effects which may reinforce their therapeutic application besides their capacity of increasing acetylcholine levels.	pyridine	102-112	amyloid beta precursor protein	Homo sapiens	48-53
16198581-10	2006	Pharmacol.2003, 55, 1397] Furthermore, the anti-Abeta fibril formation property of AChE inhibitors of pyridinium- and bispyridinium-type was evaluated to expand their activity profile and to reveal potential additive pharmacological effects which may reinforce their therapeutic application besides their capacity of increasing acetylcholine levels.	pyridine	102-112	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87
17260673-1	2006	Mono-Mannich bases derived from acetophenones, 1-aryl-3-amino- 1 -propanone hydrochlorides (Igl-Ig4), and their corresponding azine derivatives, N, N"-bis(3-amino-l-aryl-propylidene) hydrazine dihydrochlorides (DI-D4), were designed and synthesized as cellular thiol alkylating agents.	pyridine	126-131	immunoglobulin lambda locus	Homo sapiens	92-95
17109392-2	2006	The versatility of PLP in carrying out a large variety of reactions exploiting the electron sink effect of the pyridine ring, the conformational changes accompanying the chemical steps and stabilizing distinct catalytic intermediates, and the spectral properties of the different coenzyme-substrate derivatives signaling the reaction progress, are some of the features that have attracted our interest to investigate the structure-dynamics-function relationships of PLP-dependent enzymes.	pyridine	111-119	pyridoxal phosphatase	Homo sapiens	19-22
16482258-1	2006	The adsorption of pyridine onto silver colloids has been investigated by Raman spectroscopy experiments and by ab initio DFT and MP2 calculations.	pyridine	18-26	tryptase pseudogene 1	Homo sapiens	129-132
16721877-4	2006	In the study on whole cell sugars, TLC both on cellulose and on silica gel revealed to be successful in the separation of the components in modified pyridine-free solvent systems.	pyridine	149-157	lipocalin 1	Homo sapiens	35-38
16211115-2	2005	The mono-, tri- and pentacationic 4-aminopyridine derivatives can be deprotonated to neutral compounds in solution, or protonated to di-, hexa- and decacationic pyridine derivatives, respectively.	pyridine	41-49	hexosaminidase subunit alpha	Homo sapiens	138-142
16375332-5	2005	Binding of the pyridine molecule in the eta1 adsorption configuration on the considered sites has corroborated the trend of Lewis acidity suggested by the electrostatic potential methodology.	pyridine	15-23	secreted phosphoprotein 1	Homo sapiens	40-44
16296858-3	2005	These studies were carried out in pyridine, conditions under which the cobalt(IV) corrole in (PCY)MClCoCl is immediately reduced to its Co(III) form, thus enabling direct comparisons with the free-base porphyrin dyad, (PCY)H2Co(III) under the same solution conditions.	pyridine	34-42	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	136-143
16296858-3	2005	These studies were carried out in pyridine, conditions under which the cobalt(IV) corrole in (PCY)MClCoCl is immediately reduced to its Co(III) form, thus enabling direct comparisons with the free-base porphyrin dyad, (PCY)H2Co(III) under the same solution conditions.	pyridine	34-42	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	139-142
16296858-6	2005	Before this study was started, it was expected that the porphyrin-corrole dyads with the largest spacers, namely, O and A, would readily accommodate the formation of cobalt(III) bis-pyridine adducts because of the larger size of the cavity while dyads with the smallest B spacer would seem to have insufficient room to add even a single pyridine within the cavity, as was structurally seen in the case of (PCB)H2Co(py).	pyridine	182-190	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	173-176
16296858-6	2005	Before this study was started, it was expected that the porphyrin-corrole dyads with the largest spacers, namely, O and A, would readily accommodate the formation of cobalt(III) bis-pyridine adducts because of the larger size of the cavity while dyads with the smallest B spacer would seem to have insufficient room to add even a single pyridine within the cavity, as was structurally seen in the case of (PCB)H2Co(py).	pyridine	182-190	pyruvate carboxylase	Homo sapiens	406-409
16296858-8	2005	A reversible Co(III)/Co(II) reaction is seen for (PCB)MnClCoCl at -0.62 V, which when combined with spectroscopic data, leads to the assignment of (PCB)Mn(III)(py)2Co(III)(py) as the species in pyridine.	pyridine	194-202	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	13-20
16296858-8	2005	A reversible Co(III)/Co(II) reaction is seen for (PCB)MnClCoCl at -0.62 V, which when combined with spectroscopic data, leads to the assignment of (PCB)Mn(III)(py)2Co(III)(py) as the species in pyridine.	pyridine	194-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
16296858-8	2005	A reversible Co(III)/Co(II) reaction is seen for (PCB)MnClCoCl at -0.62 V, which when combined with spectroscopic data, leads to the assignment of (PCB)Mn(III)(py)2Co(III)(py) as the species in pyridine.	pyridine	194-202	pyruvate carboxylase	Homo sapiens	50-53
16296858-8	2005	A reversible Co(III)/Co(II) reaction is seen for (PCB)MnClCoCl at -0.62 V, which when combined with spectroscopic data, leads to the assignment of (PCB)Mn(III)(py)2Co(III)(py) as the species in pyridine.	pyridine	194-202	pyruvate carboxylase	Homo sapiens	148-151
16296858-8	2005	A reversible Co(III)/Co(II) reaction is seen for (PCB)MnClCoCl at -0.62 V, which when combined with spectroscopic data, leads to the assignment of (PCB)Mn(III)(py)2Co(III)(py) as the species in pyridine.	pyridine	194-202	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	16-19
16296858-8	2005	A reversible Co(III)/Co(II) reaction is seen for (PCB)MnClCoCl at -0.62 V, which when combined with spectroscopic data, leads to the assignment of (PCB)Mn(III)(py)2Co(III)(py) as the species in pyridine.	pyridine	194-202	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	155-158
16296858-11	2005	Here the initial Fe(III) complex can be assigned as (PCB)Fe(III)ClCo(III)(py), which has no pyridine molecule within the cavity and the singly reduced form is characterized as (PCB)Fe(II)(py)2Co(III)(py)2, which contains two pyridine ligands inside the cavity.	pyridine	225-233	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	20-23
16296858-11	2005	Here the initial Fe(III) complex can be assigned as (PCB)Fe(III)ClCo(III)(py), which has no pyridine molecule within the cavity and the singly reduced form is characterized as (PCB)Fe(II)(py)2Co(III)(py)2, which contains two pyridine ligands inside the cavity.	pyridine	225-233	pyruvate carboxylase	Homo sapiens	53-56
16288530-1	2005	[reaction: see text] Regioselective deprotonations of (S)-nicotine and derivatives at the C-2 and C-6 positions of the pyridine ring were performed in good to excellent yields.	pyridine	119-127	complement C2	Homo sapiens	90-93
16288530-1	2005	[reaction: see text] Regioselective deprotonations of (S)-nicotine and derivatives at the C-2 and C-6 positions of the pyridine ring were performed in good to excellent yields.	pyridine	119-127	complement C6	Homo sapiens	98-101
16099440-5	2005	In contrast to this the S(N) reactions done in pure pyridine showed that a temperature- and steric-dependent, regioselective substitution took place at C-6 at temperatures from 25 to 145 degrees C. The highest regioselectivity and completeness at C-6 can be obtained at 100 degrees C for 90 h, whereas at 145 degrees C substitution also occurs at C-2.	pyridine	52-60	complement C6	Homo sapiens	152-155
16099440-5	2005	In contrast to this the S(N) reactions done in pure pyridine showed that a temperature- and steric-dependent, regioselective substitution took place at C-6 at temperatures from 25 to 145 degrees C. The highest regioselectivity and completeness at C-6 can be obtained at 100 degrees C for 90 h, whereas at 145 degrees C substitution also occurs at C-2.	pyridine	52-60	complement C6	Homo sapiens	247-250
16099440-5	2005	In contrast to this the S(N) reactions done in pure pyridine showed that a temperature- and steric-dependent, regioselective substitution took place at C-6 at temperatures from 25 to 145 degrees C. The highest regioselectivity and completeness at C-6 can be obtained at 100 degrees C for 90 h, whereas at 145 degrees C substitution also occurs at C-2.	pyridine	52-60	complement C2	Homo sapiens	347-350
16136554-10	2005	Our results indicate that some dihydropyridine and pyridine compounds in our series could inhibit MRP1-mediated transport and that GSH modulation plays a minor, if any, role in this effect.	pyridine	38-46	ATP binding cassette subfamily C member 1	Homo sapiens	98-102
16172645-4	2005	Thermal measurements (TGA/DSC) indicate the de-coordination of pyridine and its loss from the solid between 360 and 380 K. (207)Pb CP/MAS NMR spectroscopy also demonstrates the existence of the Pb-N bond through observation of (1)J((207)Pb,(14)N)= 63 Hz and a (207)Pb-(14)N dipolar coupling constant, of 149 Hz.	pyridine	63-71	T-box transcription factor 1	Homo sapiens	22-25
16172645-4	2005	Thermal measurements (TGA/DSC) indicate the de-coordination of pyridine and its loss from the solid between 360 and 380 K. (207)Pb CP/MAS NMR spectroscopy also demonstrates the existence of the Pb-N bond through observation of (1)J((207)Pb,(14)N)= 63 Hz and a (207)Pb-(14)N dipolar coupling constant, of 149 Hz.	pyridine	63-71	desmocollin 3	Homo sapiens	26-29
16025282-5	2005	The technique demonstrates the formation of red colored complexes between nicotine and pyridine and ferro-hemochromes such as hemoglobin, myoglobin and other cytochromes in tissues, giving specimens a natural color.	pyridine	87-95	myoglobin	Homo sapiens	138-147
16853223-9	2005	The ability of added polyanion to compete with the betaine carboxylic groups in binding with the pyridinium groups was supported by potentiometric titration of PCB-n mixtures with sodium poly(styrenesulfonate): for n &gt; or = 2, the binding of the polyanion-competitor also shifted protonation of carboxylic groups to higher values with DeltapH of more than 2 units.	pyridine	97-107	pyruvate carboxylase	Homo sapiens	160-163
18007345-2	2005	The Co(III)ion is six-coordinated with octahedral geometry, the pyridine rings are planar and the piperazine rings assume chair conformations.	pyridine	64-72	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	4-11
15747319-3	2005	However, in the case of Z-Gly-2Pyg-Gly-OMe, the intramolecular hydrogen bonding between 2Pyg-NH and the pyridine nitrogen was not observed, whereas Z-Aib-2Pyg-Aib-OMe adopts a unique conformation with an intramolecular hydrogen bond between 2Pyg-NH and a pyridine nitrogen.	pyridine	104-112	ANIB1	Homo sapiens	150-153
15747319-3	2005	However, in the case of Z-Gly-2Pyg-Gly-OMe, the intramolecular hydrogen bonding between 2Pyg-NH and the pyridine nitrogen was not observed, whereas Z-Aib-2Pyg-Aib-OMe adopts a unique conformation with an intramolecular hydrogen bond between 2Pyg-NH and a pyridine nitrogen.	pyridine	104-112	ANIB1	Homo sapiens	159-162
15747319-3	2005	However, in the case of Z-Gly-2Pyg-Gly-OMe, the intramolecular hydrogen bonding between 2Pyg-NH and the pyridine nitrogen was not observed, whereas Z-Aib-2Pyg-Aib-OMe adopts a unique conformation with an intramolecular hydrogen bond between 2Pyg-NH and a pyridine nitrogen.	pyridine	255-263	ANIB1	Homo sapiens	150-153
15747319-3	2005	However, in the case of Z-Gly-2Pyg-Gly-OMe, the intramolecular hydrogen bonding between 2Pyg-NH and the pyridine nitrogen was not observed, whereas Z-Aib-2Pyg-Aib-OMe adopts a unique conformation with an intramolecular hydrogen bond between 2Pyg-NH and a pyridine nitrogen.	pyridine	255-263	ANIB1	Homo sapiens	159-162
16124830-3	2005	This isoindoline binds to Cd2+ as a charge-neutral, zwitterionic, bidentate ligand using imine and pyridine nitrogen atoms to form the eight-coordinate fluxional complex, Cd(6"-MeLH)2(NO3)2.	pyridine	99-107	CD2 molecule	Homo sapiens	26-29
15957054-4	2005	Compound 1 reacts with pyridine and 3,5-dimethylpyridine to form Lewis base adducts of the type [(eta2-pz)ReO3(L)](3: L = py; 4: L = 3,5-Me2py).	pyridine	23-31	DNA polymerase iota	Homo sapiens	98-102
16852423-1	2005	The surface acidity of an activated eta-alumina catalyst has been investigated by examining the interaction of pyridine with the catalyst by a combination of gravimetric and volumetric adsorption isotherms, infrared spectroscopy (diffuse reflectance and transmission), inelastic neutron scattering spectroscopy, temperature-programmed desorption spectroscopy, and gravimetric desorption experiments.	pyridine	111-119	endothelin receptor type A	Homo sapiens	36-39
16787309-0	2005	A pyridinium-substituted analog of the TRH-like tripeptide pGlu-Glu-Pro-NH2 and its prodrugs as central nervous system agents.	pyridine	2-12	thyrotropin releasing hormone	Mus musculus	39-42
15934732-1	2005	The reaction of fac-[NEt(4)](2)[Re(CO)(3)Br(3)] with (S)-(2-(2"-pyridyl)ethyl)cysteamine, L(1), in methanol leads to the formation of the cationic fac-[Re(CO)(3)(NSN)][Br] complex, 1, with coordination of the nitrogen of the pyridine, the sulfur of the thioether, and the nitrogen of the primary amine.	pyridine	225-233	FA complementation group C	Homo sapiens	16-19
15625718-4	2005	Molecular calculations of the phenazopyridines 2-4 show that the pyridine and phenyl groups are oriented in an antiperiplanar conformation with intramolecular hydrogen bonding between the N-b atom and the C-2 amino group preserving the E-azo stereochemistry.	pyridine	37-45	complement C2	Homo sapiens	205-208
16851457-9	2005	When the applied potential is cast as a deviation from the PZF, the effect of pyridine is to reduce adhesion between gold and mica.	pyridine	78-86	MHC class I polypeptide-related sequence A	Homo sapiens	126-130
16851457-11	2005	In addition, we show that pyridine adsorption affects the capacitance of the gold-mica interface.	pyridine	26-34	MHC class I polypeptide-related sequence A	Homo sapiens	82-86
16787309-4	2005	The novel analog maintained its antidepressant potency but showed reduced analeptic action compared to [Glu2]TRH; thus, an increase in the selectivity of CNS-action was obtained by the incorporation of the pyridinium moiety.	pyridine	206-216	thyrotropin releasing hormone	Mus musculus	109-112
16839083-1	2005	pi-pi Interaction in pyridine dimer and trimer has been investigated in different geometries and orientations at the ab initio (HF, MP2) and DFT (B3LYP) levels of theory using various basis sets (6-31G, 6-31G, 6-311++G) and corrected for basis set superposition error (BSSE).	pyridine	21-29	tryptase pseudogene 1	Homo sapiens	132-135
15689156-2	2005	The alkenyl motif of CA-4 was replaced either by a five-membered heterocyclic (isoxazoline or isoxazole) or by a six-membered ring (pyridine or benzene).	pyridine	132-140	carbonic anhydrase 4	Homo sapiens	21-25
15634016-0	2005	5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6.	pyridine	65-73	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	123-143
15664829-1	2005	Part 2: SAR studies on the pyridine ring 3-substituent.	pyridine	27-35	sarcosine dehydrogenase	Homo sapiens	8-11
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	pyridine	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-256
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	pyridine	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	pyridine	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	267-273
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	pyridine	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	pyridine	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
16839083-3	2005	The calculated MP2/6-311++G binding energy (100% BSSE corrected) of the parallel-sandwich, antiparallel-sandwich, parallel-displaced, antiparallel-displaced, T-up and T-down geometries for pyridine dimer are 1.53, 3.05, 2.39, 3.97, 1.91, 1.47 kcal/mol, respectively.	pyridine	189-197	tryptase pseudogene 1	Homo sapiens	15-18
16421897-10	2005	CYP2C11 expression was highly variable and suppressed by pyridine, whereas the expression of CYP2E1 was suppressed by dexamethasone.	pyridine	57-65	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	0-7
15566287-5	2004	Homology modeling and docking studies support experimental data and highlight the crucial role for the hydrogen bond between the pyridine nitrogen in position 3 of 5 and the NH-indole ring of Trp6.48, which is favorably oriented in the alpha(2C)-subtype, only.	pyridine	129-137	transient receptor potential cation channel subfamily C member 6	Homo sapiens	192-196
15610027-6	2004	The pyridine hemochromagen redox difference spectrum for heme x covalently bound to the cytochrome b polypeptide isolated from SDS-PAGE displays a low-amplitude broad spectrum with a peak at 553 nm, similar to that of other hemes with a single thioether linkage.	pyridine	4-12	cytochrome b	Chlamydomonas reinhardtii	88-100
15537357-1	2004	Metabolically stable and centrally acting thyrotropin-releasing hormone (TRH) analogues were designed by replacing the central histidine with substituted pyridinium moieties.	pyridine	154-164	thyrotropin releasing hormone	Rattus norvegicus	73-76
15497993-5	2004	Reaction of 6 with pyridine and pyrazine, on the other hand, gave anti-pyridinium and pyrazinium salts, respectively, apparently via equilibration of initially formed syn products.	pyridine	19-27	synemin	Homo sapiens	167-170
15465335-6	2004	From observations of the SAR and modeling studies, we suggested the possibilities that the formation of hydrogen bond with the oxide anion in the "cation hole" and the affinity of cationic pyridine ring to S4 subsite were responsible for increase in anti-fXa activity.	pyridine	189-197	coagulation factor X	Homo sapiens	255-258
15537357-0	2004	Centrally acting and metabolically stable thyrotropin-releasing hormone analogues by replacement of histidine with substituted pyridinium.	pyridine	127-137	thyrotropin releasing hormone	Rattus norvegicus	42-71
15537357-1	2004	Metabolically stable and centrally acting thyrotropin-releasing hormone (TRH) analogues were designed by replacing the central histidine with substituted pyridinium moieties.	pyridine	154-164	thyrotropin releasing hormone	Rattus norvegicus	42-71
15537357-7	2004	We have also demonstrated the benefits of the prodrug approach on the pharmacokinetics and brain uptake/retention of pyridinium-containing TRH analogues (measured by in vivo microdialysis sampling) upon systemic administration.	pyridine	117-127	thyrotropin releasing hormone	Rattus norvegicus	139-142
15707017-4	2004	Betaleukin decreased the pyridine-induced CYP2E1-dependent monooxygenation in liver and CYP1A1/2-dependent monooxygenation in kidney.	pyridine	25-33	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	42-48
15496067-3	2004	With this new method, natural marine metabolite 3-amino-1-(2-aminoimidazol-4-yl)-prop-1-ene (1) and derivatives may now be prepared from pyridine.	pyridine	137-145	PROP paired-like homeobox 1	Homo sapiens	81-87
15497993-5	2004	Reaction of 6 with pyridine and pyrazine, on the other hand, gave anti-pyridinium and pyrazinium salts, respectively, apparently via equilibration of initially formed syn products.	pyridine	71-81	synemin	Homo sapiens	167-170
15483694-0	2004	The reaction of RhCp*(CH3)2(L)(L = pyridine, dmso) with GaCp* and AlCp*: a new type of carbon-carbon bond activation reaction.	pyridine	35-43	glutaminase	Homo sapiens	56-60
15483694-1	2004	Reaction of RhCp*(L)(CH(3))(2)(L = pyridine, dmso) with equimolar amounts of GaCp* at 60 degrees C quantitatively leads to the zwitterionic species [Cp*Rh(CpMe(4)GaMe(3))].	pyridine	35-43	glutaminase	Homo sapiens	77-81
15553218-6	2004	Likewise, the oxidized derivative (i.e., the pyridine) was identified as the final product of the reaction by GC-MS. By using the technique of deuterium kinetic isotope effect, the participation of the hydrogen of the 1-position on the 1,4-DHP ring was shown not to be the rate-limiting step of the reaction.	pyridine	45-53	dihydropyrimidinase	Homo sapiens	240-243
15225717-3	2004	Substitution of an aminoalkyl group for the aromatic group at the 4-position on the core pyridine ring resulted in a marked increase in both kinase enzyme and cellular potencies, and provided potent IKK-beta inhibitors with IC(50) values of below 100 nM.	pyridine	89-97	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	199-207
15305215-2	2004	NMR analysis clearly indicated that the 2Dpy-containing tripeptides except the peptide in which AA1, AA3 = Aib, adopt a unique conformation with two intramolecular hydrogen bonds between 2Dpy-NH and a pyridine nitrogen and between AA3-NH and another pyridine nitrogen.	pyridine	201-209	AA1	Homo sapiens	96-99
15305215-2	2004	NMR analysis clearly indicated that the 2Dpy-containing tripeptides except the peptide in which AA1, AA3 = Aib, adopt a unique conformation with two intramolecular hydrogen bonds between 2Dpy-NH and a pyridine nitrogen and between AA3-NH and another pyridine nitrogen.	pyridine	201-209	ANIB1	Homo sapiens	107-110
15305215-2	2004	NMR analysis clearly indicated that the 2Dpy-containing tripeptides except the peptide in which AA1, AA3 = Aib, adopt a unique conformation with two intramolecular hydrogen bonds between 2Dpy-NH and a pyridine nitrogen and between AA3-NH and another pyridine nitrogen.	pyridine	250-258	AA1	Homo sapiens	96-99
15514770-5	2004	The bi- or terdentate nitrogen molecules 2,2"-bipy, phen or terpy reacted with 1 in acetonitrile or pyridine to give [UO2(OTf)2(bipy)2](7), [UO2(phen)3][OTf]2(8), [UO2(OTf)2(terpy)](9) and [UO2(terpy)2][OTf]2(10), respectively.	pyridine	100-108	POU class 2 homeobox 2	Homo sapiens	122-127
15225718-3	2004	Modification of a novel IKK-beta inhibitor 1 (IKK-beta IC(50)=1500 nM, Cell IC(50)=8000 nM) at the 4-phenyl ring and 6-phenol group on the pyridine core ring resulted in a marked increased in biological activities.	pyridine	139-147	inhibitor of kappaB kinase beta	Mus musculus	24-32
15225718-3	2004	Modification of a novel IKK-beta inhibitor 1 (IKK-beta IC(50)=1500 nM, Cell IC(50)=8000 nM) at the 4-phenyl ring and 6-phenol group on the pyridine core ring resulted in a marked increased in biological activities.	pyridine	139-147	inhibitor of kappaB kinase beta	Mus musculus	46-54
15969157-0	2004	Binding of Cd2+ to self-assembled bilayers bearing pyridine terminal groups: attenuated total reflection Fourier transform infrared spectroscopic studies.	pyridine	51-59	CD2 molecule	Homo sapiens	11-14
15212527-5	2004	This protonation results in reaction of the C-2 with the unprotonated fraction of the pyridine ring to form the reactive derivatives.	pyridine	86-94	complement C2	Homo sapiens	44-47
15381984-7	2004	The single-crystal structure of the desolvated form [Co(INA)(2)] shows that there is no change in the overall connectivity on desolvation, but the rotational positions of the pyridine rings are altered.	pyridine	175-183	internexin neuronal intermediate filament protein alpha	Homo sapiens	56-59
15381984-9	2004	When the synthesis was conducted in 1-propanol solvent [Co(INA)(2)]x0.5Pr(n)OHxH(2)O, was obtained, and a single-crystal X-ray structure revealed the same overall connectivity as in but with pyridine rings disordered over closed and open positions.	pyridine	191-199	internexin neuronal intermediate filament protein alpha	Homo sapiens	59-62
15267241-0	2004	Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones.	pyridine	53-61	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	14-23
15969157-2	2004	In direct analogy with the behavior found for a variety of genuine pyridine (py) and bipyridine (bipy) metal ion complexes, Cd2+ binding to both SAMs led to shifts in the skeletal vibrational modes of the corresponding uncoordinated ligands in the region 1650-1400 cm(-1), toward higher energies.	pyridine	67-75	CD2 molecule	Homo sapiens	124-127
15969157-2	2004	In direct analogy with the behavior found for a variety of genuine pyridine (py) and bipyridine (bipy) metal ion complexes, Cd2+ binding to both SAMs led to shifts in the skeletal vibrational modes of the corresponding uncoordinated ligands in the region 1650-1400 cm(-1), toward higher energies.	pyridine	67-69	CD2 molecule	Homo sapiens	124-127
15081432-3	2004	Based on their common pyridine functionality, we hypothesized that these two molecules could inhibit human P450 enzymes.	pyridine	22-30	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	107-111
14585685-1	2004	Silk fibroin (Bombyx mori) was sulfated using chlorosulfonic acid in pyridine.	pyridine	69-77	fibroin light chain	Bombyx mori	5-12
15045105-3	2004	This compound dissolved in pyridine and thf to give the red adducts [UO2I2L3][L = py (2) or thf (3)], which were also obtained from the metathetical reaction of UO2(OTf)2 and KI.	pyridine	27-35	POU class 2 homeobox 2	Homo sapiens	161-170
15006392-0	2004	Peroxidase catalyzed formation of azine pigments--a convenient and sensitive method for the identification of human cells with positive myeloperoxidase reactivity.	pyridine	34-39	myeloperoxidase	Homo sapiens	136-151
15012082-3	2004	The C(2)-symmetric bis(benzimidazole) core adopts a highly ruffled conformation with the ortho-substituted benzene rings located anti relative to the pyridine-bearing strap.	pyridine	150-158	serine/threonine kinase receptor associated protein	Homo sapiens	167-172
15012984-1	2004	The inhibition of the tumor-associated transmembrane carbonic anhydrase IX (CA IX) isozyme possessing an extracellular active site has been investigated with a series of positively-charged, pyridinium derivatives of sulfanilamide, homosulfanilamide and 4-aminoethylbenzenesulfonamide.	pyridine	190-200	carbonic anhydrase 9	Homo sapiens	53-74
15012984-1	2004	The inhibition of the tumor-associated transmembrane carbonic anhydrase IX (CA IX) isozyme possessing an extracellular active site has been investigated with a series of positively-charged, pyridinium derivatives of sulfanilamide, homosulfanilamide and 4-aminoethylbenzenesulfonamide.	pyridine	190-200	carbonic anhydrase 9	Homo sapiens	76-81
15012994-2	2004	The p38 alpha SAR is consistent with a mode of binding wherein the benzimidazolone carbonyl serves as the H-bond acceptor to Met109 of p38 alpha in a manner analogous to the pyridine nitrogen of prototypical pyridylimidazole p38 inhibitors.	pyridine	174-182	mitogen-activated protein kinase 14	Homo sapiens	4-13
15012994-2	2004	The p38 alpha SAR is consistent with a mode of binding wherein the benzimidazolone carbonyl serves as the H-bond acceptor to Met109 of p38 alpha in a manner analogous to the pyridine nitrogen of prototypical pyridylimidazole p38 inhibitors.	pyridine	174-182	sarcosine dehydrogenase	Homo sapiens	14-17
15012994-2	2004	The p38 alpha SAR is consistent with a mode of binding wherein the benzimidazolone carbonyl serves as the H-bond acceptor to Met109 of p38 alpha in a manner analogous to the pyridine nitrogen of prototypical pyridylimidazole p38 inhibitors.	pyridine	174-182	mitogen-activated protein kinase 14	Homo sapiens	135-144
15012994-2	2004	The p38 alpha SAR is consistent with a mode of binding wherein the benzimidazolone carbonyl serves as the H-bond acceptor to Met109 of p38 alpha in a manner analogous to the pyridine nitrogen of prototypical pyridylimidazole p38 inhibitors.	pyridine	174-182	mitogen-activated protein kinase 14	Homo sapiens	4-7
15356712-4	2004	Reactions of the (por)Ru(ArNO)(2) complexes with excess pyridine and 1-methylimidazole produce the mono-nitrosoarene complexes (por)Ru(ArNO)(py) and (por)Ru(ArNO)(1-MeIm), respectively.	pyridine	56-64	cytohesin 2	Homo sapiens	25-29
15123284-6	2004	a pyridine side chain with C15 in S configuration, and (4).	pyridine	2-10	placenta associated 8	Homo sapiens	27-30
15356712-4	2004	Reactions of the (por)Ru(ArNO)(2) complexes with excess pyridine and 1-methylimidazole produce the mono-nitrosoarene complexes (por)Ru(ArNO)(py) and (por)Ru(ArNO)(1-MeIm), respectively.	pyridine	56-64	cytohesin 2	Homo sapiens	135-139
15356712-5	2004	The IR spectra of these mono-nitrosoarene complexes reveal a lowering of nu(NO) by 14-44 cm(-1), a feature consistent with the replacement of one of the pi-acid ArNO ligands with the more basic pyridine and 1-MeIm ligands.	pyridine	194-202	cytohesin 2	Homo sapiens	161-165
15356712-4	2004	Reactions of the (por)Ru(ArNO)(2) complexes with excess pyridine and 1-methylimidazole produce the mono-nitrosoarene complexes (por)Ru(ArNO)(py) and (por)Ru(ArNO)(1-MeIm), respectively.	pyridine	56-64	cytohesin 2	Homo sapiens	135-139
14649840-1	2003	Heating a toluene solution of Cp*(CO)(C5H5N)FeSiMe2NPh2 led to insertion of pyridine into the iron-silicon bond to form Cp*(CO)Fe[eta3(C,C,C)-C5H5NSiMe2NPh2].	pyridine	76-84	neurexophilin 2	Homo sapiens	51-55
15356719-4	2004	The structure of L(5) shows 3 methanol solvent molecules all of which form 2 or 3 hydrogen bonds with triazine nitrogen atoms, amide nitrogen or oxygen atoms, or pyridine nitrogen atoms.	pyridine	162-170	ribosomal protein L5	Homo sapiens	17-21
14658904-2	2003	Upon exposure of these layers to pyridine vapors, the fast reaction with formation of 6-coordinate nitro-pyridine porphyrins (Py)Co(III)(TPP)(NO2) occurs.	pyridine	33-41	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	129-136
14658868-2	2003	These TBCs were synthesized via a ring-contraction reaction mediated by PBr3 in pyridine in which a meso-nitrogen atom is extruded from an appropriate phthalocyanine precursor.	pyridine	80-88	E2F transcription factor 1	Homo sapiens	72-76
12898686-6	2003	It is shown that Co(I) is stabilized more by ZnBr(2) than by pyridine.	pyridine	61-69	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	17-22
14561087-6	2003	Pharmacophores with good hydrogen bonding potential, such as morpholine, pyridine, and imidazole, shift the melting temperature of p38alpha by 16-17 degrees C translating into K(d) values of 50-100 pM.	pyridine	73-81	mitogen-activated protein kinase 14	Homo sapiens	131-139
14505381-1	2003	One-pot condensation of PhPH2, phthaloyl chloride, and the azine of 2-carboxybenzaldehyde (1) results in the new phosphine, rac-N,N"-phthaloyl-2,3-(2-carboxyphenyl)-phenyl-3,4-diazaphospholane (rac-2), in 88% yield.	pyridine	59-64	Rac family small GTPase 2	Homo sapiens	194-199
12878181-6	2003	LH1 and LH2a expression and production led to an increase in total pyridinium cross-link production.	pyridine	67-77	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	Rattus norvegicus	0-3
12878181-6	2003	LH1 and LH2a expression and production led to an increase in total pyridinium cross-link production.	pyridine	67-77	LIM homeobox 2	Rattus norvegicus	8-12
13129580-5	2003	We identified a major metabolite, M-1, generated by human liver microsomes as 20a, a hydroxylated compound at the pyridine ring of 3.	pyridine	114-122	myoregulin	Homo sapiens	34-37
12919724-7	2003	As expected, acetone and pyridine treatments resulted in a 2- to 3-fold increase of p-NPH activity and CYP2E1 apo-protein content in liver, but not the mRNA levels.	pyridine	25-33	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	103-109
12798321-5	2003	Substitution at the 5-position of the pyridine ring and conversion of the aldehyde to ketones led to a series of potent inhibitors of caspase-3.	pyridine	38-46	caspase 3	Homo sapiens	134-143
12636387-2	2003	The availability of both H-6 and H-3 protons on the pyridine nucleus was found to be critical to ensure complete C-3 lithiation.	pyridine	52-60	H6 family homeobox 1	Homo sapiens	25-36
12841242-2	2003	Dinuclear mu-oxo osmium porphyrins containing terminal Os=CPh2 bonds with a linear C=Os-O-Os=C moiety were prepared, which are reactive toward pyridine to form [Os(Por)(CPh2)(py)] and are active catalysts for inter- and intra-molecular cyclopropanation of alkenes and for carbene insertion into saturated C-H bonds.	pyridine	143-151	cytochrome p450 oxidoreductase	Homo sapiens	164-167
12832126-8	2003	The replacement of the pyrazine ring of amiloride by a pyridine ring or by a phenyl increased the potency and the NHE selectivity.	pyridine	55-63	solute carrier family 9 member C1	Homo sapiens	114-117
12695348-5	2003	The reasonable correlation between lipophilicity and CYP2D6 inhibition by pyridiniums and 1,2,3,6-tetrahydropyridines was only limited to straight chain N-alkyl analogs, since certain N-alkylaryl analogs of lower lipophilicity were better CYP2D6 inhibitors.	pyridine	74-85	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	53-59
12695348-5	2003	The reasonable correlation between lipophilicity and CYP2D6 inhibition by pyridiniums and 1,2,3,6-tetrahydropyridines was only limited to straight chain N-alkyl analogs, since certain N-alkylaryl analogs of lower lipophilicity were better CYP2D6 inhibitors.	pyridine	74-85	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	239-245
12693054-4	2002	The rearrangement observed for 1 is suppressed on steric grounds by Me-substitution of the pyridine ring at the 6-position, the dimeric phosphazane [ClP(mu-N-6-Me-py)]2 (4) (6-Me-py = 6-methyl-2-pyridyl) being formed almost exclusively in the 1:1 reaction of PCl3 with 6-Me-pyNHLi.	pyridine	91-99	PHD finger protein 19	Homo sapiens	259-263
12598727-4	2003	Our findings may explain the diarrhoea and colicky abdominal pain produced by inflammatory bowel disease, and by IK1-blocking pyridine drugs prescribed for neuromuscular disorders.	pyridine	126-134	potassium calcium-activated channel subfamily N member 4	Homo sapiens	113-116
12580498-7	2003	The levels of pyridine depend on the type of cigarette: for a full flavor cigarette pyridine is as high as 18.0 microg/cigarette (cig.).	pyridine	14-22	fibronectin 1	Homo sapiens	45-48
12580498-7	2003	The levels of pyridine depend on the type of cigarette: for a full flavor cigarette pyridine is as high as 18.0 microg/cigarette (cig.).	pyridine	84-92	fibronectin 1	Homo sapiens	45-48
12604705-9	2003	We hypothesize the N-n-octyl group on the pyridinium nitrogen of NONI facilitates brain entry via the BBB choline transporter.	pyridine	42-52	solute carrier family 6 member 8	Rattus norvegicus	106-125
14529407-16	2003	NRH and reduced pyridinium derivatives that, like NRH, act as co-substrates for NQO2, produce a dramatic increase in the cytotoxicity of CB 1954 against human cell lines in vitro and its anti-tumor activity against certain human xenografts in vivo.	pyridine	16-26	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	80-84
12392744-0	2002	Modification of the pyridine moiety of non-peptidyl indole GnRH receptor antagonists.	pyridine	20-28	gonadotropin releasing hormone receptor	Rattus norvegicus	59-72
12444763-0	2002	Providing a chemical basis toward understanding the histidine base-on motif of methylcobalamin-dependent methionine synthase: an improved purification of methylcobinamide, plus thermodynamic studies of methylcobinamide binding exogenous imidazole and pyridine bases.	pyridine	251-259	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	105-124
12396038-1	2002	[60]fullerene has been shown to form 1:1 molecular complexes with pyridine and some methylated pyridines such as 2-picoline, 3-picoline, 4-picoline, 2,6-lutidine and 2,4,6-collidine in CCl4 medium by absorption spectrometric method.	pyridine	66-74	C-C motif chemokine ligand 4	Homo sapiens	185-189
12217367-1	2002	Electrostatic potential surface mapping of various aromatic ring systems contained in 5-HT(3)R agonists indicate that some agonists contain an aromatic moiety capable of a favorable cation-pi interaction next to the e-face of pyridine (or its bioisostere).	pyridine	226-234	5-hydroxytryptamine receptor 3A	Homo sapiens	86-94
12431079-5	2002	Thus, Mo(PMe3)6 reacts with pyridine to give an eta2-pyridyl derivative [eta2-(C5H4N)]Mo(PMe3)4H as a result of alpha-C-H bond cleavage, whereas quinoline and acridine give products of the type (eta6-ArH)Mo(PMe3)3 in which both ligands coordinate in an eta6-manner.	pyridine	28-36	DNA polymerase iota	Homo sapiens	48-52
12431079-5	2002	Thus, Mo(PMe3)6 reacts with pyridine to give an eta2-pyridyl derivative [eta2-(C5H4N)]Mo(PMe3)4H as a result of alpha-C-H bond cleavage, whereas quinoline and acridine give products of the type (eta6-ArH)Mo(PMe3)3 in which both ligands coordinate in an eta6-manner.	pyridine	28-36	DNA polymerase iota	Homo sapiens	73-77
12460116-11	2002	The following residues should be noted: lysine forming a Schiff base with the PLP aldehyde group, an adjacent histidine, and aspartic acid that establishes a link with nitrogen of the PLP pyridine ring.	pyridine	188-196	proteolipid protein 1	Homo sapiens	184-187
12200543-3	2002	First, the scaffold of intestinal fatty acid binding protein (IFABP) was tailored by molecular modeling and site-directed mutagenesis to position a carboxylate group close to the pyridine nitrogen of the cofactor.	pyridine	179-187	fatty acid binding protein 2	Homo sapiens	23-60
12147272-0	2002	CYP1A1 induction by pyridine and its metabolites in HepG2 cells.	pyridine	20-28	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
12147272-1	2002	Pyridine and its metabolites have been shown in previous studies to induce cytochrome P4501A1 (CYP1A1) expression in vivo in the rat and in vitro in cultured human lung explants.	pyridine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	75-93
12147272-1	2002	Pyridine and its metabolites have been shown in previous studies to induce cytochrome P4501A1 (CYP1A1) expression in vivo in the rat and in vitro in cultured human lung explants.	pyridine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	95-101
12147272-3	2002	This was accomplished by comparing pyridine, 2-hydroxypyridine, 3-hydroxypyridine, pyridine N-oxide, and N-methylpyridinium in terms of the induction of CYP1A1 mRNA, CYP1A1 catalytic activity, and a xenobiotic response element-directed chloramphenicol acetyltransferase reporter gene, using HepG2 cells as the experimental system.	pyridine	35-43	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	153-159
12147272-4	2002	We also assessed the effect of expression of the pyridine-metabolizing enzyme cytochrome P4502E1 on CYP1A1 induction by the parent pyridine.	pyridine	49-57	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	100-106
12147272-4	2002	We also assessed the effect of expression of the pyridine-metabolizing enzyme cytochrome P4502E1 on CYP1A1 induction by the parent pyridine.	pyridine	131-139	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	100-106
12147272-7	2002	Pyridine elevated CYP1A1 mRNA abundance 4.6-fold in HepG2 cells transfected with a human CYP2E1 expression vector relative to the abundance of the transcript in empty vector-transfected (control) HepG2 cells; the elevation was inhibited by the CYP2E1 inhibitor dimethyl sulfoxide.	pyridine	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	18-24
12147272-7	2002	Pyridine elevated CYP1A1 mRNA abundance 4.6-fold in HepG2 cells transfected with a human CYP2E1 expression vector relative to the abundance of the transcript in empty vector-transfected (control) HepG2 cells; the elevation was inhibited by the CYP2E1 inhibitor dimethyl sulfoxide.	pyridine	0-8	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	89-95
12147272-7	2002	Pyridine elevated CYP1A1 mRNA abundance 4.6-fold in HepG2 cells transfected with a human CYP2E1 expression vector relative to the abundance of the transcript in empty vector-transfected (control) HepG2 cells; the elevation was inhibited by the CYP2E1 inhibitor dimethyl sulfoxide.	pyridine	0-8	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	244-250
12147272-8	2002	The results indicate that CYP1A1 induction by pyridine is mediated largely by metabolites, the formation of which may be catalyzed by CYP2E1.	pyridine	46-54	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-32
12147272-8	2002	The results indicate that CYP1A1 induction by pyridine is mediated largely by metabolites, the formation of which may be catalyzed by CYP2E1.	pyridine	46-54	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	134-140
12160395-3	2002	Addition of PPh(3) to 2 in pyridine results in the formation of [(TBP)(8)CzCo(III)(PPh(3))] (3), which was characterized by X-ray crystallography.	pyridine	27-35	TATA-box binding protein	Homo sapiens	66-69
12160395-4	2002	Likewise, addition of an excess of pyridine to 2 in CH(2)Cl(2) followed by slow diffusion of MeOH gives [(TBP)(8)CzCo(III)(py)(2)] (4) as a crystalline solid, which was also characterized by X-ray crystallography.	pyridine	35-43	TATA-box binding protein	Homo sapiens	106-109
12203329-4	2002	Specifically, the effects that these differences have on the axial ligation properties of the Zn(II), Mg(II), Ni(II), and Co(II) complexes of P, Pc, Cn, and Hpc in toluene using pyridine as the axial ligand are detailed.	pyridine	178-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
12420748-8	2002	Concerning NADPH-dependent modification of CYP2E1 protein, all of the tested CYP2E1 binders, except glycerol, prevented this process with a different potency (isoniazid &gt; 4-methylpyrazole = imidazole = pyridine 3 &gt;&gt; acetone &gt; ethanol).	pyridine	205-213	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	77-83
12205730-3	2002	Our purpose, in this study was to assess pyridinium crosslinks (PYD and DPYD) excretion in relation to the activity of RA (changes related to sulphasalazine treatment).	pyridine	41-51	dihydropyrimidine dehydrogenase	Homo sapiens	72-76
12132926-11	2002	These values also depend on the specific spacer in the complex and, like the pyridine binding constants, decrease in the order BCO &gt; BCA &gt; BCB for the biscorroles and PCO &gt; PCA &gt; PCB for the porphyrin-corrole complexes.	pyridine	77-85	pyruvate carboxylase	Homo sapiens	191-194
12200543-3	2002	First, the scaffold of intestinal fatty acid binding protein (IFABP) was tailored by molecular modeling and site-directed mutagenesis to position a carboxylate group close to the pyridine nitrogen of the cofactor.	pyridine	179-187	fatty acid binding protein 2	Homo sapiens	62-67
12005500-0	2002	Unusual reactivity of methylene group adjacent to pyridine-2-carboxamido moiety in iron(III) and cobalt(III) complexes.	pyridine	50-58	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	88-91
11937337-1	2002	Pyridine and benzene bioisosteres of amiloride were synthesized and evaluated for their inhibitory potency against the sodium-hydrogen exchanger (NHE) involved in intracellular pH regulation.	pyridine	0-8	solute carrier family 9 member C1	Homo sapiens	146-149
11937337-6	2002	Our investigations demonstrated that the replacement of the pyrazine ring of amiloride by a pyridine or a phenyl ring improved the NHE inhibitory potency (phenyl &gt;pyridine &gt;pyrazine).	pyridine	92-100	solute carrier family 9 member C1	Homo sapiens	131-134
11937337-6	2002	Our investigations demonstrated that the replacement of the pyrazine ring of amiloride by a pyridine or a phenyl ring improved the NHE inhibitory potency (phenyl &gt;pyridine &gt;pyrazine).	pyridine	166-174	solute carrier family 9 member C1	Homo sapiens	131-134
12014955-1	2002	Previously we reported the identification of RPR200765A, a potent orally bioavailable pyridine-imidazole inhibitor of p38 mitogen-activated protein (MAP) kinase which suppressed paw swelling and joint pathology in streptococcal cell wall-induced arthritis.	pyridine	86-94	mitogen-activated protein kinase 14	Homo sapiens	118-121
12005500-0	2002	Unusual reactivity of methylene group adjacent to pyridine-2-carboxamido moiety in iron(III) and cobalt(III) complexes.	pyridine	50-58	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	104-107
12109104-1	2002	Four Zn(II) ions arranged within a pyridine-modified large phenolate-containing macrocyle Lpy2- encapsulate two chloranilate ions in a double bis-didentate bridging fashion; the ligands are strongly pi-pi stacked with each other with a short distance of 3.27 A and are electrochemically reduced at the same potential of -1.00 V to produce a reasonably stable biradical species with T1/2 = 60 min at 25 degrees C.	pyridine	35-43	interleukin 1 receptor like 1	Homo sapiens	382-391
11849738-2	2002	CYP1A1 transcripts were present in all of the lung specimens and were induced by the prototypic inducers 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), and by the atypical inducers pyridine, nicotine, and omeprazole.	pyridine	205-213	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
12083659-1	2002	o-Chloranil has been shown to form 1:1 molecular complexes with pyridine and 2-, 3- and 4-picolines in CCl4 medium.	pyridine	64-72	C-C motif chemokine ligand 4	Homo sapiens	103-107
12123058-1	2002	Pyridine and bis(TMS)ketene acetals (TMS = trimethylsilyl) react successively with methylchloroformate and iodine (or peracids) to give, via functionalized dihydropyridines, bicyclic nitrogen-containing lactones which have been characterized by X-ray crystallography.	pyridine	0-8	PYD and CARD domain containing	Homo sapiens	37-40
11849738-3	2002	2-Hydroxypyridine was a better inducer than pyridine, implicating metabolites in CYP1A1 induction by the parent compound.	pyridine	9-17	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	81-87
11909625-1	2002	Putrescine:SAM N-methyltransferase (PMT) catalyses the N-methylation of the diamine putrescine to form N-methylputrescine, the first specific precursor of both tropane and pyridine-type alkaloids, which are present together in the roots of Duboisia plants.	pyridine	172-180	putrescine N-methyltransferase 3	Nicotiana tabacum	36-39
11871902-2	2002	The same process, consisting of reaction with a O-silyl-protected hydroxylamine followed by mesylation in pyridine, furnished ent-3 in 55% yield when applied to L-arabinose.	pyridine	106-114	solute carrier family 29 member 3	Homo sapiens	126-131
11896707-5	2002	Reaction of 1a,b with pyridine (py) afforded the related tris(pyridine) complexes [(C5Me5)M(eta1-(N)-py)3][BF4]2 (M = Rh, Ir) (2a,b).	pyridine	22-30	secreted phosphoprotein 1	Homo sapiens	92-96
11896707-5	2002	Reaction of 1a,b with pyridine (py) afforded the related tris(pyridine) complexes [(C5Me5)M(eta1-(N)-py)3][BF4]2 (M = Rh, Ir) (2a,b).	pyridine	22-24	secreted phosphoprotein 1	Homo sapiens	92-96
11831902-5	2002	Three compounds, 9 (a tertiary pyridine), 10 (a quaternary pyridine), and 12 (a tertiary tetrahydropyridine), were found to be effective inhibitors of both BChE and AChE.	pyridine	31-39	butyrylcholinesterase	Homo sapiens	156-160
11814838-0	2002	Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.	pyridine	38-48	thymidine phosphorylase	Homo sapiens	103-126
11853421-3	2002	The reaction of (i-PrSi(OH)O)4 with (i-PrPhClSiO)2 in pyridine gave the tetraphenyl tricyclic laddersiloxane.	pyridine	54-62	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	19-23
11857709-4	2002	Similar adsorption experiments with one of the corresponding [2x2] Co(II) grid-type complexes on graphite, led also to a well-organised structure with interdigitation of the extra-pyridine moieties.	pyridine	180-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
11831902-5	2002	Three compounds, 9 (a tertiary pyridine), 10 (a quaternary pyridine), and 12 (a tertiary tetrahydropyridine), were found to be effective inhibitors of both BChE and AChE.	pyridine	31-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	165-169
11738613-1	2002	A compound named HPH-Pep, a peptide constructed from pyridine and histidine units, showed sensitizing effect on the hyperthermic treatment of L-1210, Molt-4, and HL60 cells.	pyridine	53-61	progestagen associated endometrial protein	Homo sapiens	21-24
11782167-6	2002	Reductive elimination in pyridine leads to quantitative isolation of mixed Ir(I) DMSO-pyridine complexes IrCl(py)(DMSO)2 (4) and [Ir(py)2(DMSO)2]PF6 (8), respectively.	pyridine	25-33	sperm associated antigen 17	Homo sapiens	145-148
11738601-1	2002	Bioisosteric replacement of the pyridine pharmacophoric element in (+/-)-pyrido[3.4-b]homotropane (PHT) and pyrido[3.4-b]tropane with the pyridazine and pyrimidine nucleus resulted in hitherto unknown nAChR ligands such as 5-8.	pyridine	32-40	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	201-206
12387936-5	2002	The FC activity of this fraction was determined by means of the pyridine hemochromogen method.	pyridine	64-72	ferrochelatase	Gallus gallus	4-6
11826867-0	2002	Urinary excretion of pyridinium crosslinks in short children treated with growth hormone.	pyridine	21-31	growth hormone 1	Homo sapiens	74-88
11765789-2	2001	Absorption, fluorescence excitation and fluorescence spectra have revealed that the monocation (MC) of DMAPPI, protonated at the imidazole nitrogen (MC2) (Scheme 2) is present in the S0 state at w0 = 0, along with the MC, protonated at pyridine nitrogen (MC3) and only normal emission is observed from both MC2 and MC3.	pyridine	236-244	melanocortin 5 receptor	Homo sapiens	149-152
11681918-3	2001	Reaction of K(2)[Ru(bpy)(NO(2))(4)] with pyridine under mild or forcing conditions produces fac-K[Ru(bpy)(NO(2))(3)(py)] and cis-[Ru(NO(2))(2)(bpy)(py)(2)] (py = pyridine), respectively.	pyridine	41-49	FA complementation group C	Homo sapiens	92-95
11681918-3	2001	Reaction of K(2)[Ru(bpy)(NO(2))(4)] with pyridine under mild or forcing conditions produces fac-K[Ru(bpy)(NO(2))(3)(py)] and cis-[Ru(NO(2))(2)(bpy)(py)(2)] (py = pyridine), respectively.	pyridine	162-170	FA complementation group C	Homo sapiens	92-95
12369967-3	2001	Monocyclic dihydropyridine and pyridine also proved to be potent selective A(3) AR antagonists.	pyridine	18-26	adenosine A3 receptor	Homo sapiens	75-82
11846329-6	2001	Serum levels of 1,25(OH)2D3 (p&lt;0.01) and PTH (p&lt;0.01) were negatively correlated with disease activity, the excretion of urinary pyridinium crosslinks showed a positive correlation with disease activity (p&lt;0.01), and 1,25(OH)2D3 and PTH were positively correlated with bAP (p&lt;0.01).	pyridine	135-145	parathyroid hormone	Homo sapiens	44-47
11846329-6	2001	Serum levels of 1,25(OH)2D3 (p&lt;0.01) and PTH (p&lt;0.01) were negatively correlated with disease activity, the excretion of urinary pyridinium crosslinks showed a positive correlation with disease activity (p&lt;0.01), and 1,25(OH)2D3 and PTH were positively correlated with bAP (p&lt;0.01).	pyridine	135-145	parathyroid hormone	Homo sapiens	242-245
11719700-11	2001	Although the contribution of nicotine to ACTE-mediated 2E1 inhibition is probably modest, pyridine alkaloid-mediated CYP 2E1 inhibition is a possible mechanism for the observed inhibition of NNK and NDMA mutagenicity by nicotine and cotinine in vitro.	pyridine	90-98	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	117-124
11765789-2	2001	Absorption, fluorescence excitation and fluorescence spectra have revealed that the monocation (MC) of DMAPPI, protonated at the imidazole nitrogen (MC2) (Scheme 2) is present in the S0 state at w0 = 0, along with the MC, protonated at pyridine nitrogen (MC3) and only normal emission is observed from both MC2 and MC3.	pyridine	236-244	melanocortin 3 receptor	Homo sapiens	255-258
11765789-2	2001	Absorption, fluorescence excitation and fluorescence spectra have revealed that the monocation (MC) of DMAPPI, protonated at the imidazole nitrogen (MC2) (Scheme 2) is present in the S0 state at w0 = 0, along with the MC, protonated at pyridine nitrogen (MC3) and only normal emission is observed from both MC2 and MC3.	pyridine	236-244	melanocortin 5 receptor	Homo sapiens	307-310
11765789-2	2001	Absorption, fluorescence excitation and fluorescence spectra have revealed that the monocation (MC) of DMAPPI, protonated at the imidazole nitrogen (MC2) (Scheme 2) is present in the S0 state at w0 = 0, along with the MC, protonated at pyridine nitrogen (MC3) and only normal emission is observed from both MC2 and MC3.	pyridine	236-244	melanocortin 3 receptor	Homo sapiens	315-318
11531430-8	2001	These Co(III) corroles strongly coordinate two pyridine molecules or one carbon monoxide molecule in CH(2)Cl(2) media, and ligand binding constants were evaluated using spectroscopic and electrochemical methods.	pyridine	47-55	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	6-13
16256695-3	2001	Despite the variety of reactions catalyzed by B6-dependent enzymes, the mechanism of almost all such enzymes is based on their ability to stabilize high-energy anionic intermediates in their reaction pathways by the pyridinium moiety of PLP/PMP.	pyridine	216-226	pyridoxal phosphatase	Homo sapiens	237-240
11511200-2	2001	The reaction of TpWS2Cl with (i) PPh3 in pyridine and (ii) dimethyl sulfoxide affords TpWOSCl in good overall yield.	pyridine	41-49	protein phosphatase 4 catalytic subunit	Homo sapiens	33-37
11497334-10	2001	Induction of CYP2E1 by pyridine resulted in an increase in 4-VP metabolism by mouse hepatic microsomes but not by pulmonary microsomes.	pyridine	23-31	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	13-19
11454726-7	2001	Pyridine pretreatment resulted in significantly increased total CYP450 content accompanied by a 2.2-fold increase in CYP2E1 protein and 2-fold increase in enzyme activity concordant with increased liver injury of TA, suggesting mechanism-based bioactivation of TA by CYP2E1.	pyridine	0-8	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	64-70
11454726-7	2001	Pyridine pretreatment resulted in significantly increased total CYP450 content accompanied by a 2.2-fold increase in CYP2E1 protein and 2-fold increase in enzyme activity concordant with increased liver injury of TA, suggesting mechanism-based bioactivation of TA by CYP2E1.	pyridine	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	117-123
11454726-7	2001	Pyridine pretreatment resulted in significantly increased total CYP450 content accompanied by a 2.2-fold increase in CYP2E1 protein and 2-fold increase in enzyme activity concordant with increased liver injury of TA, suggesting mechanism-based bioactivation of TA by CYP2E1.	pyridine	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	267-273
11457072-5	2001	However, the theory is apparently undermined by the similar splitting reported for the 2-picoline (2-pic) and pyridine (py) adducts of Co(II) cobinamide (Co(II)Cbi(+)), adducts thought to have long and normal Co-N axial bond lengths, respectively.	pyridine	110-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
11425547-0	2001	Potent nonpeptide GnRH receptor antagonists derived from substituted indole-5-carboxamides and -acetamides bearing a pyridine side-chain terminus.	pyridine	117-125	gonadotropin releasing hormone receptor	Homo sapiens	18-31
11278561-0	2001	Two new elastin cross-links having pyridine skeleton.	pyridine	35-43	elastin	Bos taurus	8-15
11278561-2	2001	Isolation and structure analysis of two amino acids from bovine ligamentum nuchae elastin hydrolysates revealed the presence of pyridine cross-links in elastin.	pyridine	128-136	elastin	Bos taurus	82-89
11278561-2	2001	Isolation and structure analysis of two amino acids from bovine ligamentum nuchae elastin hydrolysates revealed the presence of pyridine cross-links in elastin.	pyridine	128-136	elastin	Bos taurus	152-159
11278561-12	2001	Although DESP and IDP are present at only trace concentrations in the tissue elastin, these pyridine cross-links may be useful biomarkers for the aortic elastin damaged by ammonia.	pyridine	92-100	elastin	Rattus norvegicus	153-160
11899248-6	2001	Inhibitor binding to fXa was increased by the introduction of a hydroxyl group on the proximal phenylamidine ring and by the introduction of fluorine atoms at C-3 and C-5 of the pyridine ring.	pyridine	178-186	coagulation factor X	Homo sapiens	21-24
11457072-5	2001	However, the theory is apparently undermined by the similar splitting reported for the 2-picoline (2-pic) and pyridine (py) adducts of Co(II) cobinamide (Co(II)Cbi(+)), adducts thought to have long and normal Co-N axial bond lengths, respectively.	pyridine	110-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
11222868-4	2001	Pyridine increased CYP2E1 expression in both liver and kidney microsomes, whereas clofibrate had no effect on hepatic but increased renal CYP2E1 and CYP2C11 protein levels.	pyridine	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	19-25
11266153-1	2001	The syntheses and in vitro evaluation of a new series of pyrido[2,3-d]pyrimidine-2,4-diones bearing substituents at C-3 and/or C-4 positions on the pyridine ring are described.	pyridine	148-156	complement C4A (Rodgers blood group)	Homo sapiens	127-130
11181506-1	2001	Pyridine (PY) effects on rat hepatic cytochromes P450 (CYP) 3A1 and 3A2 expression were examined at the levels of metabolic activity, protein, and mRNA and were compared with those of CYP2B1/2 and CYP2E1.	pyridine	0-8	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	37-71
11181506-1	2001	Pyridine (PY) effects on rat hepatic cytochromes P450 (CYP) 3A1 and 3A2 expression were examined at the levels of metabolic activity, protein, and mRNA and were compared with those of CYP2B1/2 and CYP2E1.	pyridine	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	197-203
11181506-1	2001	Pyridine (PY) effects on rat hepatic cytochromes P450 (CYP) 3A1 and 3A2 expression were examined at the levels of metabolic activity, protein, and mRNA and were compared with those of CYP2B1/2 and CYP2E1.	pyridine	10-12	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	37-71
11300564-2	2001	The method is illustrated by describing the vibrational modes of BCl3-NH3 and BCl3-pyridine electron donor-acceptor complexes in terms of motions of BCl3 and either NH3 or pyridine.	pyridine	83-91	BCL3 transcription coactivator	Homo sapiens	65-69
11300564-2	2001	The method is illustrated by describing the vibrational modes of BCl3-NH3 and BCl3-pyridine electron donor-acceptor complexes in terms of motions of BCl3 and either NH3 or pyridine.	pyridine	83-91	BCL3 transcription coactivator	Homo sapiens	78-82
11300564-2	2001	The method is illustrated by describing the vibrational modes of BCl3-NH3 and BCl3-pyridine electron donor-acceptor complexes in terms of motions of BCl3 and either NH3 or pyridine.	pyridine	83-91	BCL3 transcription coactivator	Homo sapiens	78-82
11300564-6	2001	For the BCl3-pyridine complex, a band observed at 1107 cm(-1) is re-assigned as a combination of C-H in-plane bending and a ring-breathing mode of the pyridine fragment.	pyridine	13-21	BCL3 transcription coactivator	Homo sapiens	8-12
11154840-2	2001	Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other pyridines to form pyridinium ions.	pyridine	108-118	nicotinamide N-methyltransferase	Homo sapiens	0-32
11154840-2	2001	Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other pyridines to form pyridinium ions.	pyridine	108-118	nicotinamide N-methyltransferase	Homo sapiens	34-38
11154584-1	2000	Reactions of coordinatively unsaturated Ru[N(Ph2PQ)2]2(PPh3) (Q = S (1), Se (2)) with pyridine (py), SO2, and NH3 afford the corresponding 18e adducts Ru[N(Ph2PQ)2]2(PPh3)(L) (Q = S, L = NH3 (5); Q = Se, L = py (3), SO2 (4), NH3 (6)).	pyridine	86-94	protein phosphatase 4 catalytic subunit	Homo sapiens	55-59
11147993-4	2000	In addition, a significant positive correlation between TNF-alpha, CRP, BASDAI, and urinary pyridinium cross-link excretion was proved, besides a significant negative correlation of IGF-I to urinary pyridinium cross-links and TNF-alpha levels.	pyridine	92-102	tumor necrosis factor	Homo sapiens	56-65
11147993-4	2000	In addition, a significant positive correlation between TNF-alpha, CRP, BASDAI, and urinary pyridinium cross-link excretion was proved, besides a significant negative correlation of IGF-I to urinary pyridinium cross-links and TNF-alpha levels.	pyridine	92-102	insulin like growth factor 1	Homo sapiens	182-187
11147993-4	2000	In addition, a significant positive correlation between TNF-alpha, CRP, BASDAI, and urinary pyridinium cross-link excretion was proved, besides a significant negative correlation of IGF-I to urinary pyridinium cross-links and TNF-alpha levels.	pyridine	92-102	tumor necrosis factor	Homo sapiens	226-235
11147993-4	2000	In addition, a significant positive correlation between TNF-alpha, CRP, BASDAI, and urinary pyridinium cross-link excretion was proved, besides a significant negative correlation of IGF-I to urinary pyridinium cross-links and TNF-alpha levels.	pyridine	199-209	insulin like growth factor 1	Homo sapiens	182-187
11150166-2	2000	The piperidinopyrimidine OSC inhibitors have a significantly lower pK(a) than the corresponding pyridine or the previously reported quinuclidine OSC inhibitor series.	pyridine	96-104	lanosterol synthase	Rattus norvegicus	25-28
11361020-0	2001	Oxodesmosine and isooxodesmosine, candidates of oxidative metabolic intermediates of pyridinium cross-links in elastin.	pyridine	85-95	elastin	Bos taurus	111-118
11774366-6	2001	NNN, a pyridine derivative of NPYR, was activated by CYP1A1 at an efficiency similar to that of CYP2A6.	pyridine	7-15	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-59
11774366-7	2001	NABS, a pyridine derivative of NPIP, was mainly activated by CYP3A4, followed by CYP1A1 and CYP2A6.	pyridine	8-16	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	61-67
11774366-8	2001	Thus, the addition of a pyridine ring to NPYR or NPIP altered the forms of CYP primarily responsible for mutagenic activation.	pyridine	24-32	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	75-78
11149843-2	2000	The pyridine ring of pyrazoloquinolines 14 and 18 was formed via cyclization of a formyl group at C-4 or C-5 and an amino group of a 2-aminophenyl substituent at C-5 or C-4 in 1-benzyloxypyrazole.	pyridine	4-12	complement C4A (Rodgers blood group)	Homo sapiens	98-108
11149843-2	2000	The pyridine ring of pyrazoloquinolines 14 and 18 was formed via cyclization of a formyl group at C-4 or C-5 and an amino group of a 2-aminophenyl substituent at C-5 or C-4 in 1-benzyloxypyrazole.	pyridine	4-12	complement C5	Homo sapiens	162-172
11149843-3	2000	The pyridine ring of pyrazoloisoquinolines 5 and 9 was created via cyclization of a formyl group in a 2-formylphenyl substituent at C-4 or C-5 with an iminophosphorane group installed at C-5 or C-4 of 1-benzyloxypyrazole by lithiation followed by reaction with tosyl azide and then with tributylphoshine utilizing the Staudinger/aza-Wittig protocol.	pyridine	4-12	complement C4A (Rodgers blood group)	Homo sapiens	132-135
11149843-3	2000	The pyridine ring of pyrazoloisoquinolines 5 and 9 was created via cyclization of a formyl group in a 2-formylphenyl substituent at C-4 or C-5 with an iminophosphorane group installed at C-5 or C-4 of 1-benzyloxypyrazole by lithiation followed by reaction with tosyl azide and then with tributylphoshine utilizing the Staudinger/aza-Wittig protocol.	pyridine	4-12	complement C5	Homo sapiens	139-142
11149843-3	2000	The pyridine ring of pyrazoloisoquinolines 5 and 9 was created via cyclization of a formyl group in a 2-formylphenyl substituent at C-4 or C-5 with an iminophosphorane group installed at C-5 or C-4 of 1-benzyloxypyrazole by lithiation followed by reaction with tosyl azide and then with tributylphoshine utilizing the Staudinger/aza-Wittig protocol.	pyridine	4-12	complement C5	Homo sapiens	187-190
11154584-1	2000	Reactions of coordinatively unsaturated Ru[N(Ph2PQ)2]2(PPh3) (Q = S (1), Se (2)) with pyridine (py), SO2, and NH3 afford the corresponding 18e adducts Ru[N(Ph2PQ)2]2(PPh3)(L) (Q = S, L = NH3 (5); Q = Se, L = py (3), SO2 (4), NH3 (6)).	pyridine	86-88	protein phosphatase 4 catalytic subunit	Homo sapiens	55-59
10901708-13	2000	CYP2C19 favors 5-hydroxylation of the pyridine group of R-omeprazole, whereas the same enzyme mainly 5-O-demethylates S-omeprazole in the benzimidazole group.	pyridine	38-46	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
10993266-5	2000	The lability of 8 and 9 is illustrated by the reactions with pyridine and NaX (X=Cl, Br, I, N3) which afford the mono(diphenyldiazomethane)rhodium(I) compounds trans-[Rh(PiPr3)2(py)(eta1-N2CPh2)]PF6 (10) and trans-[RhX(eta1-N2CPh2)(PiPr3)2] (11-14), respectively.	pyridine	61-69	sperm associated antigen 17	Homo sapiens	195-198
10945627-9	2000	Other reduced pyridinium compounds can also act as co-substrates for NQO2.	pyridine	14-24	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	69-73
10945627-13	2000	A negatively charged substituent at the 3-position of the reduced pyridine ring also negated the ability of these compounds to act as cosubstrates for NQO2.	pyridine	66-74	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	151-155
10970306-3	2000	The partitioning ratio of the reactive intermediate (PBr(+)) between reversal and product formation (k(-)(d)/k(2)) is not particularly sensitive to the nature of the pyridine, the limiting values being 3-7 except in the case of bis(2(-)-menthylpyridine)bromonium triflate where the k(-)(d)/k(2) ratio is approximately 80.	pyridine	166-174	translocator protein	Homo sapiens	53-56
11196867-1	2000	Eight adducts of Rh2(O2CCH3)4 with axial pyridine derivatives that contain hydrogen-bonding amino and/or steric methyl substituents in the 2- and 6-positions have been prepared and examined by electronic absorption and 1H NMR spectroscopy in solution and by elemental, IR, thermogravimetric, and X-ray diffraction analyses in the solid state.	pyridine	41-49	Rh associated glycoprotein	Homo sapiens	17-20
11196867-2	2000	The results indicated that strong hydrogen bonding interactions between Rh2(O2CCH3)4 and axially coordinated pyridine derivatives with a 2- or 6-amino group occur in both solution and the solid state and contribute to the higher thermal stability of the molecular assembly of dirhodium complexes.	pyridine	109-117	Rh associated glycoprotein	Homo sapiens	72-75
11232812-7	2000	Electrochemical reduction of the biscarbonyl complexes with Y = Cl- and pyridine in MeCN resulted in efficient ligand substitution to give the solvento complexes cis,trans-[Re(X2bpy)(CO)2(PR3)(MeCN)]+.	pyridine	72-80	proteinase 3	Homo sapiens	188-191
10860547-0	2000	Comparative induction of CYP1A1 expression by pyridine and its metabolites.	pyridine	46-54	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	25-31
10860547-1	2000	We compared pyridine and five of its metabolites in terms of (i) in vivo induction of CYP1A1 expression in the lung, kidney, and liver in the rat and (ii) in vitro binding to, and activation of, the aryl hydrocarbon receptor (AhR) in cytosol from rat liver or Hepa1c1c7 cells.	pyridine	12-20	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	86-92
10860547-1	2000	We compared pyridine and five of its metabolites in terms of (i) in vivo induction of CYP1A1 expression in the lung, kidney, and liver in the rat and (ii) in vitro binding to, and activation of, the aryl hydrocarbon receptor (AhR) in cytosol from rat liver or Hepa1c1c7 cells.	pyridine	12-20	aryl hydrocarbon receptor	Rattus norvegicus	199-224
10860547-1	2000	We compared pyridine and five of its metabolites in terms of (i) in vivo induction of CYP1A1 expression in the lung, kidney, and liver in the rat and (ii) in vitro binding to, and activation of, the aryl hydrocarbon receptor (AhR) in cytosol from rat liver or Hepa1c1c7 cells.	pyridine	12-20	aryl hydrocarbon receptor	Rattus norvegicus	226-229
10860547-5	2000	Pyridine and its metabolites elicited weak activation of the aryl hydrocarbon receptor in a gel retardation assay in cytosol from rat liver but not Hepa 1c1c7 cells.	pyridine	0-8	aryl hydrocarbon receptor	Rattus norvegicus	61-86
10860547-8	2000	The findings are consistent with a role of pyridine metabolites in CYP1A1 induction by pyridine but do not clearly identify the role of aryl hydrocarbon receptor in the induction mechanism.	pyridine	87-95	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	67-73
10773587-12	2000	We conclude that osteoclast activation is an early event in PTHrP-mediated osteolysis, which is closely reflected by the renal excretion of pyridinium cross-links of type I collagen.	pyridine	140-150	parathyroid hormone-like hormone	Rattus norvegicus	60-65
10805768-2	2000	Initial screening showed that only L-lactate dehydrogenase and citrate synthase were inhibited but only by two specific CD dimers in which two beta-CDs were linked on the secondary face by a pyridine-2,6-dicarboxylic group.	pyridine	191-199	citrate synthase	Homo sapiens	63-79
12835094-3	2000	MPTP is bioactivated by brain monoamine oxidase B (MAO-B) to its neurotoxic pyridinium metabolite 1-methyl-4-phenylpyridinium (MPP(+)) which destroys dopaminergic nerve terminals leading to the depletion of neostriatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC).	pyridine	76-86	monoamine oxidase B	Mus musculus	30-49
10753671-9	2000	However, PAK-104P, a pyridine analog that reverses MDR associated with P-gp and MRP1, inhibited the transporting activity of MRP1 stronger than that of YCF1.	pyridine	21-29	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	152-156
12835094-3	2000	MPTP is bioactivated by brain monoamine oxidase B (MAO-B) to its neurotoxic pyridinium metabolite 1-methyl-4-phenylpyridinium (MPP(+)) which destroys dopaminergic nerve terminals leading to the depletion of neostriatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC).	pyridine	76-86	monoamine oxidase B	Mus musculus	51-56
10640507-2	2000	CYP2E1 levels are post-transcriptionally elevated in response to certain xenobiotic inducers (e.g., pyridine), and proposed mechanisms include increased translational efficiency and protection of the enzyme from ubiquitin-dependent proteolysis.	pyridine	100-108	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	0-6
11229557-9	2000	The air- and moisture-stable polymeric clusters easily decompose into small molecular clusters when treated with ligands such as PPh3 and pyridine (Py).	pyridine	148-150	protein phosphatase 4 catalytic subunit	Homo sapiens	129-133
10889318-1	1999	Synthesis of non-basic thrombin inhibitors incorporating pyridinium-sulfanilylguanidine moieties at the P1 site.	pyridine	57-67	coagulation factor II, thrombin	Homo sapiens	23-31
10995066-1	2000	Synthesis of weakly basic thrombin inhibitors incorporating pyridinium-sulfanilylaminoguanidine moieties.	pyridine	60-70	coagulation factor II, thrombin	Homo sapiens	26-34
10600517-7	1999	Also, the specificity for cathepsin L could be explained by the existence of Phe in the P2 site and hydrophobic interaction of N-terminal pyridine ring.	pyridine	138-146	cathepsin L	Homo sapiens	26-37
10805063-2	2000	It is now commonly agreed that the oxidation of 1,4-dihydropyridine into pyridine, which is one of the main metabolic pathways, is catalysed by the cytochrome P450 (CYP) 3A4 isoform.	pyridine	59-67	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	148-163
10805063-2	2000	It is now commonly agreed that the oxidation of 1,4-dihydropyridine into pyridine, which is one of the main metabolic pathways, is catalysed by the cytochrome P450 (CYP) 3A4 isoform.	pyridine	59-67	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	165-168
10625598-7	2000	The SUR2 segment containing the 12th through 17th predicted transmembrane domains, TMD12-17, confers sensitivity to the benzopyran, cromakalim, and the pyridine, pinacidil, whereas an SUR1 segment which includes TMD6-11 and the first nucleotide-binding fold, NBF1, controls responsiveness to the benzothiadiazine, diazoxide.	pyridine	152-160	ATP binding cassette subfamily C member 9	Homo sapiens	4-8
10585182-4	1999	A mixed monolayer consisting of pyridine and nitrospiropyran (1a) photoisomerizable units assembled on a Au-electrode acts as a command interface for the light-controlled association and dissociation of Cyt c to and from the monolayer.	pyridine	32-40	cytochrome c, somatic	Homo sapiens	203-208
10585182-5	1999	Cyt c binds to the pyridine/1a-monolayer electrode, resulting in electrical contact between the redox protein and the electrode.	pyridine	19-27	cytochrome c, somatic	Homo sapiens	0-5
10585182-6	1999	Photoisomerization of the mixed monolayer to the pyridine/protonated merocyanine state (1b) results in the electrostatic repulsion of Cyt c and its dissociation from the electrode support.	pyridine	49-57	cytochrome c, somatic	Homo sapiens	134-139
10491133-9	1999	Only SIN-1, which produces peroxynitrite by generating both NO and superoxide anion, decreased the Soret region absorption and the pyridine hemochromogen spectrum of HO-2; superoxide dismutase (SOD) blocked the decrease.	pyridine	131-139	MAPK associated protein 1	Homo sapiens	5-10
10491133-9	1999	Only SIN-1, which produces peroxynitrite by generating both NO and superoxide anion, decreased the Soret region absorption and the pyridine hemochromogen spectrum of HO-2; superoxide dismutase (SOD) blocked the decrease.	pyridine	131-139	heme oxygenase 2	Homo sapiens	166-170
10413312-0	1999	Coordinate up-regulation of CYP1A1 and heme oxygenase-1 (HO-1) expression and modulation of delta-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats.	pyridine	166-174	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	28-34
10413312-0	1999	Coordinate up-regulation of CYP1A1 and heme oxygenase-1 (HO-1) expression and modulation of delta-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats.	pyridine	166-174	heme oxygenase 1	Rattus norvegicus	39-55
10413312-0	1999	Coordinate up-regulation of CYP1A1 and heme oxygenase-1 (HO-1) expression and modulation of delta-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats.	pyridine	166-174	heme oxygenase 1	Rattus norvegicus	57-61
10413312-0	1999	Coordinate up-regulation of CYP1A1 and heme oxygenase-1 (HO-1) expression and modulation of delta-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats.	pyridine	166-174	tryptophan 2,3-dioxygenase	Rattus norvegicus	131-151
10413312-6	1999	Similar to the induction of HO-1 expression, lipid peroxidation was stimulated by pyridine treatment in the kidney, lung, and liver, but with the stimulation being more persistent in the liver and lung than in the kidney.	pyridine	82-90	heme oxygenase 1	Rattus norvegicus	28-32
10413312-8	1999	Pyridine treatment negatively modulated heme saturation of hepatic TPO.	pyridine	0-8	tryptophan 2,3-dioxygenase	Rattus norvegicus	67-70
10413312-9	1999	The findings indicate that pyridine stimulates the synthesis, utilization, and degradation of heme in a coordinate manner, and suggest that these alterations in heme metabolism may contribute to CYP1A1 induction by pyridine.	pyridine	27-35	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	195-201
10413312-9	1999	The findings indicate that pyridine stimulates the synthesis, utilization, and degradation of heme in a coordinate manner, and suggest that these alterations in heme metabolism may contribute to CYP1A1 induction by pyridine.	pyridine	215-223	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	195-201
10463385-0	1999	Constitutive and induced expression by pyridine and beta-naphthoflavone of rat CYP1A is sexually dimorphic.	pyridine	39-47	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	79-84
10397507-2	1999	Structure-activity relationship studies have demonstrated that central pyridine ring substituents play an important role in the COX-2 potency, selectivity vs the COX-1 enzyme, and oral activity.	pyridine	71-79	prostaglandin-endoperoxide synthase 2	Homo sapiens	128-133
10397507-2	1999	Structure-activity relationship studies have demonstrated that central pyridine ring substituents play an important role in the COX-2 potency, selectivity vs the COX-1 enzyme, and oral activity.	pyridine	71-79	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	162-167
10463385-6	1999	Pyridine treatment upregulated CYP1A1 mRNA and its protein in the lung, kidney and liver in female rats, and upregulated the mRNA but not the protein in the lung and liver in male rats.	pyridine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	31-37
10463385-7	1999	Conversely, pyridine induced both CYP1A2 mRNA and protein in the liver in female rats, whereas it induced the protein but not its mRNA in the liver in male rats.	pyridine	12-20	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	34-40
10463385-10	1999	The results show that the constitutive as well as inducible expression of CYP1A is sexually dimorphic in the Sprague-Dawley rat, with females being more responsive than males to induction by pyridine but with males being more responsive than females to induction by betaNF.	pyridine	191-199	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	74-79
10463385-11	1999	The findings support the involvement of different mechanisms in CYP1A induction by pyridine and betaNF.	pyridine	83-91	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	64-69
10599348-2	1999	In patients with rheumatoid arthritis, significant positive correlations were found between urinary pyridinium crosslinks and C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and articular index.	pyridine	100-110	C-reactive protein	Homo sapiens	126-144
10218814-1	1999	The parkinsonian inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is bioactivated in a reaction catalyzed by the flavoenzyme monoamine oxidase B (MAO-B) to form the corresponding dihydropyridinium and subsequently pyridinium metabolites.	pyridine	203-213	monoamine oxidase B	Homo sapiens	142-161
10218814-1	1999	The parkinsonian inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is bioactivated in a reaction catalyzed by the flavoenzyme monoamine oxidase B (MAO-B) to form the corresponding dihydropyridinium and subsequently pyridinium metabolites.	pyridine	203-213	monoamine oxidase B	Homo sapiens	163-168
10215695-3	1999	In the present study, we examined the effects of insulin on pyridine-, phenobarbital-, and ciprofibrate-mediated expression of CYP2E1, CYP2B, CYP3A, and CYP4A in primary cultured rat hepatocytes.	pyridine	60-68	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	127-133
10215695-3	1999	In the present study, we examined the effects of insulin on pyridine-, phenobarbital-, and ciprofibrate-mediated expression of CYP2E1, CYP2B, CYP3A, and CYP4A in primary cultured rat hepatocytes.	pyridine	60-68	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	142-147
10215695-4	1999	Pyridine addition to primary rat hepatocytes cultured in the presence of 1 nM insulin or in the absence of insulin resulted in a 3.5-fold and 3-fold enhancement in CYP2E1 protein expression, respectively, in the absence of any pyridine-mediated increase in mRNA expression.	pyridine	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	164-170
10215695-6	1999	Thus, the fold-induction of CYP2E1 protein in response to pyridine was 1.5- to 1.8-fold greater in either the absence of insulin or in the presence of 1 nM insulin, respectively, than that monitored in the presence of 1 microM insulin.	pyridine	58-66	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	28-34
10599348-2	1999	In patients with rheumatoid arthritis, significant positive correlations were found between urinary pyridinium crosslinks and C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and articular index.	pyridine	100-110	C-reactive protein	Homo sapiens	146-149
9836623-8	1998	SAR studies revealed that the pyridine nitrogen atom and the nature and the position of the substituents on the pyridine ring were critically involved in the ability of the compounds to recognize and activate 5-HT1A receptors.	pyridine	30-38	5-hydroxytryptamine receptor 1A	Homo sapiens	209-215
10488245-0	1999	Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphonylation of the enzyme.	pyridine	48-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
9836623-8	1998	SAR studies revealed that the pyridine nitrogen atom and the nature and the position of the substituents on the pyridine ring were critically involved in the ability of the compounds to recognize and activate 5-HT1A receptors.	pyridine	112-120	5-hydroxytryptamine receptor 1A	Homo sapiens	209-215
9719457-0	1998	Rhodamine 123 efflux modulation in the presence of low or high serum from CD56+ hematopoietic cells or CD34+ leukemic blasts by B9309-068, a newly designed pyridine derivative.	pyridine	156-164	neural cell adhesion molecule 1	Homo sapiens	74-78
29711132-2	1998	In the synthesis of [{Be(SPh)2 (py)(NH3 )}2 {[18]crown-6}] (1, py=pyridine) from [Be{N(SiMe3 )2 }2 ] and HSPh, the coordinated ammonia molecules (see the structure of 1 in the picture) are formed in a competing reaction between liberated hexamethyldisilazane and the thiol.	pyridine	32-34	ankyrin 1	Homo sapiens	25-30
29711132-2	1998	In the synthesis of [{Be(SPh)2 (py)(NH3 )}2 {[18]crown-6}] (1, py=pyridine) from [Be{N(SiMe3 )2 }2 ] and HSPh, the coordinated ammonia molecules (see the structure of 1 in the picture) are formed in a competing reaction between liberated hexamethyldisilazane and the thiol.	pyridine	66-74	ankyrin 1	Homo sapiens	25-30
9873621-2	1998	Optimum COX-2 activity is observed by introduction of a substituent at C5 of the central pyridine.	pyridine	89-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
9733494-2	1998	Here we report the synthesis and in vitro nAChR binding of a series of 10 pyridine-modified analogues of A-85380.	pyridine	74-82	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	42-47
9693382-9	1998	Inactivation of RhoA with C3 transferase and inhibition of the Rho-kinase p160ROCK with the pyridine derivative Y-27632 completely abolished activation of NHE1 by integrins but not by platelet-derived growth factor.	pyridine	92-100	sodium/hydrogen exchanger 1	Cricetulus griseus	155-159
9618253-9	1998	These results indicate that cytochrome P450 2E1 is present in the rat testis, and that it is elevated by the treatment of the animals with pyridine.	pyridine	139-147	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	28-47
9618463-5	1998	The biphenylamidine of FX-2212a occupies the S1-pocket, and the pyridine ring makes hydrophobic interactions with the factor Xa aryl-binding site.	pyridine	64-72	coagulation factor X	Homo sapiens	118-127
9494110-5	1998	We find that CD38-catalysed cleavage of the nicotinamide-ribose bond results in the formation of an E.ADP-ribosyl intermediary complex, which is common to all reaction pathways; this intermediate reacts (1) with acceptors such as water (hydrolysis), methanol (methanolysis) or pyridine (transglycosidation), and (2) intramolecularly, yielding cyclic ADP-ribose with a low efficiency.	pyridine	277-285	CD38 molecule	Homo sapiens	13-17
9495846-1	1998	The present report describes in vitro studies demonstrating that the heterocyclic substituted pyridine compound (+/-)-2-(3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429) is extremely potent in activating human muscle nicotine ACh receptor (nAChR) (EC50 = 59 +/- 17 nM; Emax = 110 +/- 09% vs. nicotine).	pyridine	94-102	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	218-239
9495846-1	1998	The present report describes in vitro studies demonstrating that the heterocyclic substituted pyridine compound (+/-)-2-(3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429) is extremely potent in activating human muscle nicotine ACh receptor (nAChR) (EC50 = 59 +/- 17 nM; Emax = 110 +/- 09% vs. nicotine).	pyridine	94-102	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	241-246
9701495-1	1998	A new series of pyridine-containing analogues III-XXII of distamycin A and netrop sin was investigated by the molecular mechanics technique and molecular modelling.	pyridine	16-24	embryonal Fyn-associated substrate	Homo sapiens	82-85
9305573-2	1997	The most dramatic illustration of this type of bioactivation process is the conversion of the parkinsonian-inducing neurotoxin MPTP (23) by brain MAO-B to the iminium (dihydropyridinium) metabolite 24 which is oxidized further to the pyridinium species MPP+ (25).	pyridine	175-185	monoamine oxidase B	Homo sapiens	146-151
9395280-1	1997	The pyridine derivative cerivastatin is a new entirely synthetic and enantiomerically pure inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase.	pyridine	4-12	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	104-154
9365408-0	1997	Urine pyridinium cross-links determinations by Beckman Cross Links Kit.	pyridine	6-16	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	67-70
9278260-0	1997	Effect of pyridine on the expression of cytochrome P450 isozymes in primary rat hepatocyte culture.	pyridine	10-18	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	40-55
9233381-6	1997	Pyridine, an inducer of CYP2E1, increased S-SO but not R-SO formation in liver.	pyridine	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	24-30
9278260-13	1997	These results indicate that pyridine has different effects on CYP1A and CYP2E1 in this hepatocyte culture model.	pyridine	28-36	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	72-78
9278260-1	1997	In vivo administration of pyridine has been shown to increase the activity and content of several forms of cytochrome P450 by transcriptional and posttranscriptional mechanisms.	pyridine	26-34	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	107-122
9278260-14	1997	Pyridine appears to modulate CYP2E1 levels by posttranscriptional mechanisms as CYP2E1 activity and content were maintained in the presence of pyridine under conditions in which CYP2E1 mRNA levels declined.	pyridine	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	29-35
9278260-14	1997	Pyridine appears to modulate CYP2E1 levels by posttranscriptional mechanisms as CYP2E1 activity and content were maintained in the presence of pyridine under conditions in which CYP2E1 mRNA levels declined.	pyridine	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	80-86
9278260-12	1997	CYP1A2, but not CYP1A1, mRNA levels increased in the cultures incubated in the absence of pyridine.	pyridine	90-98	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	0-6
9278260-2	1997	The effect of pyridine on CYP1A and CYP2E1 isozymes was studied in a rat hepatocyte culture model.	pyridine	14-22	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	36-42
9278260-14	1997	Pyridine appears to modulate CYP2E1 levels by posttranscriptional mechanisms as CYP2E1 activity and content were maintained in the presence of pyridine under conditions in which CYP2E1 mRNA levels declined.	pyridine	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	80-86
9278260-6	1997	Pyridine prevented this decline of CYP2E1 protein and activity such that 60-80% original activity remained after 3 days of culture in the presence of 25 mM pyridine.	pyridine	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	35-41
9278260-14	1997	Pyridine appears to modulate CYP2E1 levels by posttranscriptional mechanisms as CYP2E1 activity and content were maintained in the presence of pyridine under conditions in which CYP2E1 mRNA levels declined.	pyridine	143-151	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	29-35
9278260-14	1997	Pyridine appears to modulate CYP2E1 levels by posttranscriptional mechanisms as CYP2E1 activity and content were maintained in the presence of pyridine under conditions in which CYP2E1 mRNA levels declined.	pyridine	143-151	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	80-86
9278260-6	1997	Pyridine prevented this decline of CYP2E1 protein and activity such that 60-80% original activity remained after 3 days of culture in the presence of 25 mM pyridine.	pyridine	156-164	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	35-41
9278260-14	1997	Pyridine appears to modulate CYP2E1 levels by posttranscriptional mechanisms as CYP2E1 activity and content were maintained in the presence of pyridine under conditions in which CYP2E1 mRNA levels declined.	pyridine	143-151	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	80-86
9278260-7	1997	However, pyridine did not prevent the fall in CYP2E1 mRNA levels, nor did pyridine increase the content or activity of CYP2E1 above initial values of microsomes from freshly isolated hepatocytes.	pyridine	74-82	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	119-125
9278260-16	1997	Pyridine increased CYP1A1 and CYP1A2 content, activity and mRNA levels, either inducing CYP1A transcription or stabilizing CYP1A mRNA.	pyridine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	19-25
9278260-16	1997	Pyridine increased CYP1A1 and CYP1A2 content, activity and mRNA levels, either inducing CYP1A transcription or stabilizing CYP1A mRNA.	pyridine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	30-36
9278260-8	1997	Pyridine increased the content of CYP1A2 and the oxidation of ethoxyresorufin 2-4 fold compared to cultures incubated without pyridine over the 3 day culture period.	pyridine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	34-40
9278260-9	1997	CYP1A1 levels, which rapidly declined, were induced and maintained in the presence of pyridine.	pyridine	86-94	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	0-6
9176557-4	1997	Styrene was hepatotoxic in CD-1 mice treated with pyridine to induce CYP2E1.	pyridine	50-58	CD1 antigen complex	Mus musculus	27-31
11669996-4	1997	Electron transfers and solvent exchange reactions involving three neutral Co(II) and three cationic Co(III) complexes with different axially bound solvent molecules (two DMF, one DMF and one pyridine, or two pyridine molecules) form a three-rung ladder scheme.	pyridine	191-199	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	100-107
11669996-4	1997	Electron transfers and solvent exchange reactions involving three neutral Co(II) and three cationic Co(III) complexes with different axially bound solvent molecules (two DMF, one DMF and one pyridine, or two pyridine molecules) form a three-rung ladder scheme.	pyridine	208-216	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	100-107
9266276-12	1997	These studies also demonstrate that the administration of ABT-299 to man results in potent, long lasting inhibition of PAF-mediated platelet activation, due in part to the pyridine-N-oxide metabolite, and support the potential therapeutic utility of this prodrug in treating PAF-mediated diseases.	pyridine	172-180	PCNA clamp associated factor	Homo sapiens	119-122
9176557-4	1997	Styrene was hepatotoxic in CD-1 mice treated with pyridine to induce CYP2E1.	pyridine	50-58	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	69-75
9176557-5	1997	CYP2E1 apoprotein levels and p-nitrophenol hydroxylase activities in control and pyridine-induced mice were similar in the two strains.	pyridine	81-89	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	0-6
8878114-0	1996	Effect of a pyridinium metabolite derived from haloperidol on the activities of striatal tyrosine hydroxylase in freely moving rats.	pyridine	12-22	tyrosine hydroxylase	Rattus norvegicus	89-109
9212343-11	1997	x mg-1 protein x min-1) which was completely inhibited by 50 mM pyridine.	pyridine	64-72	CD59 molecule (CD59 blood group)	Homo sapiens	17-22
11669820-2	1997	In this study, the interactions of R(2)AlX (where R = Me, (i)Bu, (t)Bu; X = Cl, Br, I) with the monodentate bases thf, pyridine, NEt(3), HN(i)Pr(2), H(2)N(i)Bu, H(2)N(t)Bu, and O=PPh(3) are examined to determine the role of the base in cation formation.	pyridine	119-127	hematopoietic SH2 domain containing	Homo sapiens	39-42
11669832-1	1997	The acidity and the process for deprotonation of (eta(6)-toluene)Fe(H)(2)(SiCl(3))(2) in acetonitrile were studied with pyridine derivatives.	pyridine	120-128	endothelin receptor type A	Homo sapiens	50-53
9163514-4	1997	The ferrous myoglobin is capable of strong binding with pyridine, imidazole, cyanide, and azide, and reacts moderately with ammonia.	pyridine	56-64	myoglobin	Homo sapiens	12-21
9144458-0	1997	Cytochrome P450 inactivation during reductive metabolism of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) by phenobarbital- and pyridine-induced rat liver microsomes.	pyridine	128-136	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
9058594-0	1997	Reversal of multidrug resistance-associated protein-mediated drug resistance by the pyridine analog PAK-104P.	pyridine	84-92	ATP binding cassette subfamily C member 3	Homo sapiens	12-51
9200411-4	1997	These parameters followed a synergic albeit asynchronous outcome: (a) lysyl oxidase mRNA levels in total kidney, glomeruli and medulla from Adriamycin-treated rats increased up to 3 times compared to controls between week 8 and 12, then returning within the normal range; (b) the pyridinium residue content did not show any significant difference between Adriamycin-treated and control rats, until diffuse interstitial fibrosis developed (16 weeks), showing at this time a 2- to 3-fold increment.	pyridine	280-290	lysyl oxidase	Rattus norvegicus	70-83
8931940-2	1996	A novel artificial peptide named HPH-Pep, comprising a pyridine and two histidine units, was synthesized.	pyridine	55-63	progestagen associated endometrial protein	Homo sapiens	37-40
9139709-3	1997	The visible and pyridine hemochromogen spectra suggest that the Escherichia coli expressed purified HO-2 is a hemoprotein.	pyridine	16-24	heme oxygenase 2	Rattus norvegicus	100-104
9008868-4	1997	The calculated MP2/6-311G(2d,p) energies gave the proton affinities of N, C-2, C-3 and C-4 in pyridine as 924, 658, 686 and 637 kJ mol-1, respectively, which were in good agreement with previous experimental and theoretical results.	pyridine	94-102	tryptase pseudogene 1	Homo sapiens	15-18
9008868-4	1997	The calculated MP2/6-311G(2d,p) energies gave the proton affinities of N, C-2, C-3 and C-4 in pyridine as 924, 658, 686 and 637 kJ mol-1, respectively, which were in good agreement with previous experimental and theoretical results.	pyridine	94-102	complement C2	Homo sapiens	74-82
9008868-4	1997	The calculated MP2/6-311G(2d,p) energies gave the proton affinities of N, C-2, C-3 and C-4 in pyridine as 924, 658, 686 and 637 kJ mol-1, respectively, which were in good agreement with previous experimental and theoretical results.	pyridine	94-102	complement C4A (Rodgers blood group)	Homo sapiens	87-90
8656450-4	1996	Pyridine, phenobarbital, and beta-naphthoflavone, inducers of CYP2E1, CYP2B, and CYP1A, respectively, increased the toxicity of styrene.	pyridine	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	62-68
8694547-3	1996	The aim of this study was to evaluate the urinary pyridinium crosslink levels in breast cancer with or without osseous involvement, and to correlate it with serial doses of CA 15-3.	pyridine	50-60	mucin 1, cell surface associated	Homo sapiens	173-180
8656450-4	1996	Pyridine, phenobarbital, and beta-naphthoflavone, inducers of CYP2E1, CYP2B, and CYP1A, respectively, increased the toxicity of styrene.	pyridine	0-8	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	70-75
8780893-0	1996	Expression of memory, differentiation, and repression of c-myc and p53 genes in human RD/TE-671 cells induced by a ureido-derivative of pyridine (UDP-4).	pyridine	136-144	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	57-62
8780893-0	1996	Expression of memory, differentiation, and repression of c-myc and p53 genes in human RD/TE-671 cells induced by a ureido-derivative of pyridine (UDP-4).	pyridine	136-144	tumor protein p53	Homo sapiens	67-70
8627283-0	1996	Azide, cyanide, fluoride, imidazole and pyridine binding to ferric and ferrous native horse heart cytochrome c and to its carboxymethylated derivative: a comparative study.	pyridine	40-48	cytochrome c, somatic	Equus caballus	98-110
8831826-1	1996	The neuroleptic agent haloperidol (HP) and its tetrahydropyridine dehydration product HPTP are biotransformed to the potentially neurotoxic HP pyridinium species HPP+ and the reduced HP pyridinium species RHPP+ in humans and rodents.	pyridine	143-153	protein tyrosine phosphatase receptor type D	Homo sapiens	86-90
8831826-1	1996	The neuroleptic agent haloperidol (HP) and its tetrahydropyridine dehydration product HPTP are biotransformed to the potentially neurotoxic HP pyridinium species HPP+ and the reduced HP pyridinium species RHPP+ in humans and rodents.	pyridine	186-196	protein tyrosine phosphatase receptor type D	Homo sapiens	86-90
8831826-8	1996	We conclude that the conversions of HP and HPTP to potentially neurotoxic pyridinium metabolite HPP+ are catalyzed selectively by P450 3A4 in human liver microsomes.	pyridine	74-84	protein tyrosine phosphatase receptor type D	Homo sapiens	43-47
8627283-1	1996	Azide, cyanide, fluoride, imidazole, and pyridine binding to ferric and ferrous native horse heart cytochrome c and to its carboxymethylated derivative has been investigated, from the thermodynamic viewpoint, at pH 7.5 and 25.0 degrees C. Ligand affinity for ferric and ferrous carboxymethylated cytochrome c is higher by about 30- and 400-fold, respectively, than that observed for the native protein.	pyridine	41-49	cytochrome c, somatic	Equus caballus	99-111
8626764-3	1996	Recent studies have shown that S-nitrosylation of GAPDH (Cys149) initiates subsequent modification by the pyridinium cofactor.	pyridine	106-116	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	50-55
8605195-9	1996	Other aromatic and fused polycyclic and heterocyclic aldehydes, as well as derivatives of coumarin, quinoline, indole, and pyridine, are tight-binding, slow-turnover substrates for ALDH-2 and relatively weak inhibitors of ALDH-1.	pyridine	123-131	aldehyde dehydrogenase 2 family member	Homo sapiens	181-187
8605195-9	1996	Other aromatic and fused polycyclic and heterocyclic aldehydes, as well as derivatives of coumarin, quinoline, indole, and pyridine, are tight-binding, slow-turnover substrates for ALDH-2 and relatively weak inhibitors of ALDH-1.	pyridine	123-131	aldehyde dehydrogenase 1 family member A1	Homo sapiens	222-228
8625499-15	1996	In microsomes from PYR-pretreated rats inhibition by mAbs also showed a role for cytochrome P450 2E1 in depropylation of NDPA.	pyridine	19-22	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	81-100
8627517-7	1996	Pyridine or phenobarbital potentiation of CCl4-induced increases in ALT activity implys that cytochrome P450 2E1 (P450 2E1) and P450 2B expression may be associated with the increased toxicity.	pyridine	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	93-112
8704044-8	1996	Multiple regression analysis (taking into account different variables of the immunosuppressive regimen applied) revealed the plasma concentration of interleukin-6 as an independent predictor of the urinary excretion of pyridinium cross-links (p &lt; 0.05).	pyridine	219-229	interleukin 6	Homo sapiens	149-162
9816180-3	1996	In the present study, the modulatory activity of the novel pyridine analogue PAK-104P on MRP-mediated resistance to doxorubicin and paclitaxel was investigated in two doxorubicin-selected human tumor cell lines [HT1080/DR4 (sarcoma) and HL60/ADR (leukemia)] and compared with the nonimmunosuppressive cyclosporine analogue PSC-833.	pyridine	59-67	ATP binding cassette subfamily C member 1	Homo sapiens	89-92
9816180-10	1996	In addition to reversing P-glycoprotein-mediated MDR, the pyridine analogue PAK-104P provides an example of an effective in vivo modulator of MRP-mediated MDR.	pyridine	58-66	ATP binding cassette subfamily C member 1	Homo sapiens	142-145
8560502-3	1995	Treatment of rats with pyridine, an inducer of CYP2E1, enhanced hepatic microsomal metabolism of benzene, although benzene, which is also considered to be an inducer of CYP2E1, did not.	pyridine	23-31	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	47-53
8560502-5	1995	When hepatic and pulmonary microsomes from control and pyridine-treated rats were incubated with benzene (17.5 microM) and the CYP2E1 inhibitor, diethyldithiocarbamate, benzene metabolism was significantly inhibited, indicating that CYP2E1 is the predominant cytochrome P-450 isozyme involved in hepatic and pulmonary metabolism in microsomes from control and pyridine-treated rats.	pyridine	55-63	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	127-133
8825185-14	1996	Pretreatment of animals with the CYP2E1 inducer pyridine for 24 hr had only a marginal effect on c-fos mRNA levels, but increased CCI4-stimulated c-fos and c-jun mRNA levels by an additional approximately 2- to approximately 4-fold over those monitored in the uninduced hepatic tissue of CCI4-treated animals.	pyridine	48-56	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	33-39
8825185-14	1996	Pretreatment of animals with the CYP2E1 inducer pyridine for 24 hr had only a marginal effect on c-fos mRNA levels, but increased CCI4-stimulated c-fos and c-jun mRNA levels by an additional approximately 2- to approximately 4-fold over those monitored in the uninduced hepatic tissue of CCI4-treated animals.	pyridine	48-56	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	97-102
8825185-14	1996	Pretreatment of animals with the CYP2E1 inducer pyridine for 24 hr had only a marginal effect on c-fos mRNA levels, but increased CCI4-stimulated c-fos and c-jun mRNA levels by an additional approximately 2- to approximately 4-fold over those monitored in the uninduced hepatic tissue of CCI4-treated animals.	pyridine	48-56	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	146-151
8825185-16	1996	Enhanced CYP2E1 or CYP2B1/2B2 levels after treatment with pyridine or phenobarbital elevated c-fos mRNA over untreated controls.	pyridine	58-66	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	9-15
8825185-16	1996	Enhanced CYP2E1 or CYP2B1/2B2 levels after treatment with pyridine or phenobarbital elevated c-fos mRNA over untreated controls.	pyridine	58-66	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	19-25
8825185-16	1996	Enhanced CYP2E1 or CYP2B1/2B2 levels after treatment with pyridine or phenobarbital elevated c-fos mRNA over untreated controls.	pyridine	58-66	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	93-98
8560502-5	1995	When hepatic and pulmonary microsomes from control and pyridine-treated rats were incubated with benzene (17.5 microM) and the CYP2E1 inhibitor, diethyldithiocarbamate, benzene metabolism was significantly inhibited, indicating that CYP2E1 is the predominant cytochrome P-450 isozyme involved in hepatic and pulmonary metabolism in microsomes from control and pyridine-treated rats.	pyridine	55-63	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	233-239
8560502-5	1995	When hepatic and pulmonary microsomes from control and pyridine-treated rats were incubated with benzene (17.5 microM) and the CYP2E1 inhibitor, diethyldithiocarbamate, benzene metabolism was significantly inhibited, indicating that CYP2E1 is the predominant cytochrome P-450 isozyme involved in hepatic and pulmonary metabolism in microsomes from control and pyridine-treated rats.	pyridine	360-368	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	127-133
8560502-8	1995	Induction of CYP2E1 and CYP2B1/2 with pyridine and phenobarbital, respectively, did not alter this lack of effect.	pyridine	38-46	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	13-19
8560502-8	1995	Induction of CYP2E1 and CYP2B1/2 with pyridine and phenobarbital, respectively, did not alter this lack of effect.	pyridine	38-46	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	24-30
8560502-3	1995	Treatment of rats with pyridine, an inducer of CYP2E1, enhanced hepatic microsomal metabolism of benzene, although benzene, which is also considered to be an inducer of CYP2E1, did not.	pyridine	23-31	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	169-175
7556172-5	1995	With potassium permanganate and osmium tetroxide/pyridine, probes for the accessibility of the 5,6 double bond of pyrimidine residues, BgPI has a more potent effect than BePI and, generally, the reaction with KMnO4 is more pronounced than that with OsO4.	pyridine	49-57	CEA cell adhesion molecule 1	Homo sapiens	135-139
8575032-5	1995	Heteroaromatic rings such as pyrrole, thiophene, furan, pyridine, pyridazine, 1,2-benzisoxazole, indole, quinoline, and isoquinoline rings showed weak 5-HT3 receptor antagonistic activity.	pyridine	56-64	5-hydroxytryptamine receptor 3A	Rattus norvegicus	151-165
7473547-11	1995	The CAR activities of pyrroles 6 and 12, thiophene 40, furans 44-47, isoxazolines 49 and 50, and pyridine 54 coupled with their weak or nonexistent D2 binding and strong 5-HT1A binding suggest that they may be acting via a nondopaminergic mechanism or that dopaminergic active metabolites are responsible.	pyridine	97-105	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	4-7
7473547-11	1995	The CAR activities of pyrroles 6 and 12, thiophene 40, furans 44-47, isoxazolines 49 and 50, and pyridine 54 coupled with their weak or nonexistent D2 binding and strong 5-HT1A binding suggest that they may be acting via a nondopaminergic mechanism or that dopaminergic active metabolites are responsible.	pyridine	97-105	5-hydroxytryptamine receptor 1A	Homo sapiens	170-176
7493548-0	1995	3-Methylcholanthrene and pyridine effects on CYP1A1 and CYP1A2 expression in rat renal tissue.	pyridine	25-33	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	45-51
7493548-0	1995	3-Methylcholanthrene and pyridine effects on CYP1A1 and CYP1A2 expression in rat renal tissue.	pyridine	25-33	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	56-62
7493548-4	1995	This approach served as the foundation for examining the effects of pyridine on CYP1A1 and 1A2 expression in renal tissue.	pyridine	68-76	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	80-94
7493548-1	1995	The effects of 3-methylcholanthrene (3-MC) and pyridine on rat renal cytochrome P450 (CYP) 1A1 and 1A2 mRNA expression have been examined by Northern-blot analysis and reverse transcriptase-polymerase chain reaction (RT-PCR), followed by Southern-blot analysis of the PCR products.	pyridine	47-55	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	69-102
7493548-5	1995	RT-PCR analysis of renal CYP1A1 and 1A2 poly(A)+ RNA levels after treatment with pyridine (200 mg/kg/day for 3 consecutive days) revealed that CYP1A1 mRNA levels were maximally elevated approximately 10-fold after pyridine treatment for 2 consecutive days, whereas CYP1A2 mRNA levels were maximally elevated approximately 3-fold at 24 hr after treatment.	pyridine	81-89	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	25-39
7546038-10	1995	Because of the redox potential (-315 mV) and the distance between the pyridinium and phosphate groups, this analogue is a hydrogen acceptor and its reduced form a hydrogen donor in tests with alcohol dehydrogenase from Thermoanaerobium brockii.	pyridine	70-80	aldo-keto reductase family 1 member A1	Homo sapiens	192-213
7493548-5	1995	RT-PCR analysis of renal CYP1A1 and 1A2 poly(A)+ RNA levels after treatment with pyridine (200 mg/kg/day for 3 consecutive days) revealed that CYP1A1 mRNA levels were maximally elevated approximately 10-fold after pyridine treatment for 2 consecutive days, whereas CYP1A2 mRNA levels were maximally elevated approximately 3-fold at 24 hr after treatment.	pyridine	81-89	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	25-31
7493548-5	1995	RT-PCR analysis of renal CYP1A1 and 1A2 poly(A)+ RNA levels after treatment with pyridine (200 mg/kg/day for 3 consecutive days) revealed that CYP1A1 mRNA levels were maximally elevated approximately 10-fold after pyridine treatment for 2 consecutive days, whereas CYP1A2 mRNA levels were maximally elevated approximately 3-fold at 24 hr after treatment.	pyridine	81-89	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	265-271
7493548-7	1995	These results show that expression of CYP1A1 and 1A2 mRNAs is enhanced in renal tissue after exposure to 3-MC or pyridine, and that constitutive expression of CYP1A1 seems to be greater than that of CYP1A2 in renal tissue.	pyridine	113-121	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	38-52
7493548-7	1995	These results show that expression of CYP1A1 and 1A2 mRNAs is enhanced in renal tissue after exposure to 3-MC or pyridine, and that constitutive expression of CYP1A1 seems to be greater than that of CYP1A2 in renal tissue.	pyridine	113-121	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	38-44
7587954-2	1995	We examined the effects of ciprofibrate (CIPRO) and pyridine (PYR) treatment on the expression of CYP2E1, P450 4A (CYP4A), and P450 2B (CYP2B) in primary rat hepatocytes cultured on Vitrogen or Matrigel substratum and in the presence of Chee"s medium.	pyridine	52-60	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	98-104
7587954-2	1995	We examined the effects of ciprofibrate (CIPRO) and pyridine (PYR) treatment on the expression of CYP2E1, P450 4A (CYP4A), and P450 2B (CYP2B) in primary rat hepatocytes cultured on Vitrogen or Matrigel substratum and in the presence of Chee"s medium.	pyridine	62-65	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	98-104
7587954-8	1995	Western blot analyses revealed that 24-hr PYR (25 mM) treatment of CIPRO-treated cells, in the absence of any further increase in CYP2E1 mRNA levels, increased CYP2E1 protein levels approximately 6- to 8-fold.	pyridine	42-45	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	160-166
7611840-0	1995	Azines and diazines as potential histamine H3-receptor antagonists.	pyridine	0-6	histamine H3 receptor	Cavia porcellus	33-54
7768907-6	1995	In addition, azaheme myoglobin forms stable complexes with imidazole, pyridine, or cyanide in ferrous state.	pyridine	70-78	myoglobin	Homo sapiens	21-30
7786305-3	1995	The nitroreductase can, like DT diaphorase, also use simple reduced pyridinium compounds as virtual cofactors.	pyridine	68-78	NAD(P)H quinone dehydrogenase 1	Homo sapiens	29-42
7932578-3	1994	Many of the compounds including those substituted with thiazole, benzothiazole, benzoxazole, imidazole, and pyridine groups exhibit IC50 potencies of PEP inhibition at nanomolar levels.	pyridine	108-116	prolyl endopeptidase	Homo sapiens	150-153
7880831-3	1995	These low-barrier hydrogen bonds are associated respectively with a side chain proton, the PLP pyridinium ring nitrogen proton, and the PLP Schiff base proton at the active site of the ligase.	pyridine	95-105	pyridoxal phosphatase	Homo sapiens	91-94
7852403-0	1995	Modulation of the heme environment of neutrophil cytochrome b558 to a "cytochrome P450-like" structure by pyridine.	pyridine	106-114	cytochrome b	Sus scrofa	49-61
7852403-1	1995	The effect of pyridine on the heme environment of cytochrome b558 was studied using ESR and optical absorption spectroscopy in relation to the O2(-)-generating activity in the NADPH oxidase system of stimulated pig neutrophils.	pyridine	14-22	cytochrome b	Sus scrofa	50-62
7852403-2	1995	As the concentration of pyridine increased, the absorption maxima of the alpha- and gamma-bands of cytochrome b558 shifted which correlated with a concomitant decrease in O2(-)-generating activity.	pyridine	24-32	cytochrome b	Sus scrofa	99-111
7852403-4	1995	The results suggest that pyridine induces a structural modification in the heme environment of cytochrome b558 by shifting the 5th heme ligand (histidine) to a nearby thiolate group without direct binding of pyridine to the heme.	pyridine	25-33	cytochrome b	Sus scrofa	95-107
7852403-4	1995	The results suggest that pyridine induces a structural modification in the heme environment of cytochrome b558 by shifting the 5th heme ligand (histidine) to a nearby thiolate group without direct binding of pyridine to the heme.	pyridine	208-216	cytochrome b	Sus scrofa	95-107
8301591-4	1994	Polyinosinic acid-polycytidylic acid down regulated the constitutive and pyridine-induced expression of CYP2E1 and the pyridine- and beta-naphthoflavone-induced expression of CYP1A1 as demonstrated by metabolic activity and immunoblot analyses.	pyridine	73-81	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	104-110
7525095-9	1994	These data indicate that pyridine administration to rats and mice induces CYP2E1 metabolism of EC in vitro, but inhibits EC metabolism in vivo, perhaps by acting as an alternate substrate for CYP2E1.	pyridine	25-33	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	74-80
7525095-9	1994	These data indicate that pyridine administration to rats and mice induces CYP2E1 metabolism of EC in vitro, but inhibits EC metabolism in vivo, perhaps by acting as an alternate substrate for CYP2E1.	pyridine	25-33	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	192-198
7914928-6	1994	Both anti-PAF and H1 antihistamine activities have shown a high dependence on the exact nature and position of the substituent in the pyridine ring.	pyridine	134-142	PCNA clamp associated factor	Rattus norvegicus	10-13
8308865-5	1994	The specificity and affinity of CNAD for ADH are likely due to coordination of the zinc cation at the ADH catalytic site by the CNAD pyridine nitrogen.	pyridine	133-141	aldo-keto reductase family 1 member A1	Homo sapiens	41-44
8308865-5	1994	The specificity and affinity of CNAD for ADH are likely due to coordination of the zinc cation at the ADH catalytic site by the CNAD pyridine nitrogen.	pyridine	133-141	aldo-keto reductase family 1 member A1	Homo sapiens	102-105
8308865-8	1994	In this analogue, displacement of the pyridine nitrogen to the opposite side of the ring removes the specificity for ADH.	pyridine	38-46	aldo-keto reductase family 1 member A1	Homo sapiens	117-120
8093035-1	1994	The present study examined changes in hepatic CYP2E1 content and (omega-1)-hydroxylation of lauric acid in rats treated with pyridine, pyrazole, acetone, ethanol and 3-methylcholanthrene.	pyridine	125-133	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	46-52
8158148-4	1994	Incubation of MBzTP with purified MAO B yields first the dihydropyridinium form, then a mixture of the pyridinium form and another unidentified product, in proportions that depend on the concentrations of MAO B and oxygen.	pyridine	64-74	monoamine oxidase B	Homo sapiens	34-39
7511897-0	1994	Evidence for multiple inducible cytochrome P450 isozymes in SENCAR mouse skin by pyridine.	pyridine	81-89	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	32-47
7511897-4	1994	Pyridine treatment also resulted in an increase in reactivity with monoclonal antibodies directed against CYP 1A1, 2B1 and 3A.	pyridine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	106-125
7511897-5	1994	In Northern blot analysis, treatment of pyridine also showed a significant increase in mRNA for Cyp1a-1 in the skin.	pyridine	40-48	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	96-103
7511897-6	1994	These data indicate that murine skin contains multiple inducible CYP isozymes, and that pyridine results in the induction of at least three families of CYP in murine skin.	pyridine	88-96	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	152-155
8289189-4	1994	The corresponding pyridinium forms of trans-MTHS and its analogs were more potent inhibitors of MAO A (Ki values between 0.3 and 5 microM) than of MAO B, for which the Ki values varied greatly.	pyridine	18-28	monoamine oxidase A	Homo sapiens	96-101
8289189-4	1994	The corresponding pyridinium forms of trans-MTHS and its analogs were more potent inhibitors of MAO A (Ki values between 0.3 and 5 microM) than of MAO B, for which the Ki values varied greatly.	pyridine	18-28	monoamine oxidase B	Homo sapiens	147-152
8301591-4	1994	Polyinosinic acid-polycytidylic acid down regulated the constitutive and pyridine-induced expression of CYP2E1 and the pyridine- and beta-naphthoflavone-induced expression of CYP1A1 as demonstrated by metabolic activity and immunoblot analyses.	pyridine	73-81	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	175-181
8301591-4	1994	Polyinosinic acid-polycytidylic acid down regulated the constitutive and pyridine-induced expression of CYP2E1 and the pyridine- and beta-naphthoflavone-induced expression of CYP1A1 as demonstrated by metabolic activity and immunoblot analyses.	pyridine	119-127	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	175-181
8246169-0	1993	Enhanced expression of rat hepatic CYP2B1/2B2 and 2E1 by pyridine: differential induction kinetics and molecular basis of expression.	pyridine	57-65	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	35-41
8113223-1	1993	We investigated the structural requirements for the induction of hepatic microsomal cytochrome P450 2B1/2 (P450 2B1/2) and cytochrome P450 1A1/2 (P450 1A1/2) by imidazole- and pyridine-containing compounds in rats.	pyridine	176-184	cytochrome P450, family 2, subfamily b, polypeptide 12	Rattus norvegicus	84-105
8113223-1	1993	We investigated the structural requirements for the induction of hepatic microsomal cytochrome P450 2B1/2 (P450 2B1/2) and cytochrome P450 1A1/2 (P450 1A1/2) by imidazole- and pyridine-containing compounds in rats.	pyridine	176-184	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	123-144
8353848-9	1993	These results show that within living cells NNK was metabolized by CYP2B1 via both the pyridine N-oxidation and alpha-carbon hydroxylation pathways.	pyridine	87-95	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	67-73
8287374-0	1993	Synergistic induction of rat microsomal CYP1A1 and CYP1A2 by acetone in combination with pyridine.	pyridine	89-97	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	40-46
8287374-1	1993	The effect of exposure to acetone, pyridine or acetone in combination with pyridine on microsomal CYP1A1, CYP1A2 and CYP2E1 levels and their catalytic activities was determined in the rat.	pyridine	75-83	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	98-104
8287374-2	1993	CYP1A1 and CYP1A2 in the liver and CYP1A1 in the lung were induced along with their catalytic activities by either pyridine, acetone or acetone and pyridine.	pyridine	115-123	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	0-6
8287374-2	1993	CYP1A1 and CYP1A2 in the liver and CYP1A1 in the lung were induced along with their catalytic activities by either pyridine, acetone or acetone and pyridine.	pyridine	115-123	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	11-17
8287374-2	1993	CYP1A1 and CYP1A2 in the liver and CYP1A1 in the lung were induced along with their catalytic activities by either pyridine, acetone or acetone and pyridine.	pyridine	115-123	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	35-41
8287374-2	1993	CYP1A1 and CYP1A2 in the liver and CYP1A1 in the lung were induced along with their catalytic activities by either pyridine, acetone or acetone and pyridine.	pyridine	148-156	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	0-6
8287374-2	1993	CYP1A1 and CYP1A2 in the liver and CYP1A1 in the lung were induced along with their catalytic activities by either pyridine, acetone or acetone and pyridine.	pyridine	148-156	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	11-17
8287374-2	1993	CYP1A1 and CYP1A2 in the liver and CYP1A1 in the lung were induced along with their catalytic activities by either pyridine, acetone or acetone and pyridine.	pyridine	148-156	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	35-41
8287374-4	1993	Acetone, pyridine or both compounds induced CYP2E1 protein to the same extent in the liver and lung.	pyridine	9-17	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	44-50
8410980-4	1993	The corresponding pyridine, pyridazine, pyrazine, and 1,2,4-triazine carboxylic acids also showed potent in vitro angiotensin II antagonism.	pyridine	18-26	angiotensinogen	Rattus norvegicus	114-128
8353848-10	1993	However, CYP2B1 preferentially catalyzed pyridine N-oxidation, which is considered to be a deactivation reaction.	pyridine	41-49	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	9-15
8343989-1	1993	Two pyridinium and two imidazolium dioximes were tested as reversible inhibitors of human erythrocyte acetylcholinesterase (AChE), as protectors of the enzyme against phosphorylation and as reactivators of the phosphorylated AChE.	pyridine	4-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	102-122
8104122-7	1993	In vitro biotransformation studies with microsomes from rats treated with pyridine, an inducer of cytochrome P-450 2E1, confirmed that cytochrome P-450 2E1 is involved in the metabolism of HCFC-141b.	pyridine	74-82	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	98-118
8104122-7	1993	In vitro biotransformation studies with microsomes from rats treated with pyridine, an inducer of cytochrome P-450 2E1, confirmed that cytochrome P-450 2E1 is involved in the metabolism of HCFC-141b.	pyridine	74-82	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	135-155
8334118-10	1993	Comparisons show that, while NADP+ and NADPH bind to DHFR with the pyridine ring and 3"-carboxamide coplanar, the thioamide group is twisted by 23 degrees from the pyridine plane in both the binary and ternary complexes.	pyridine	67-75	dihydrofolate reductase	Gallus gallus	53-57
8343989-1	1993	Two pyridinium and two imidazolium dioximes were tested as reversible inhibitors of human erythrocyte acetylcholinesterase (AChE), as protectors of the enzyme against phosphorylation and as reactivators of the phosphorylated AChE.	pyridine	4-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	124-128
8339333-1	1993	Four regioisomeric ditritylated derivatives of cyclomalto-octaose (1, cG8), namely, 6(I),6(n)-di-O-trityl-cG8S have been prepared by the reaction of 1 with chlorotriphenylmethane in pyridine and isolated by high-performance liquid chromatography.	pyridine	182-190	actin binding transcription modulator	Homo sapiens	70-73
11607345-1	1993	Electron microscopic observation provides insight into the nature of the polymeric supramolecular liquid crystalline species (TP2, TU2)n formed by polyassociation of the complementary components TP2 and TU2 derived from D-, L-, or meso-tartaric acid (where T is any form of tartaric acid, D is the D species, and L is the L species) and from pyridine (P) and uracil (U) derivatives.	pyridine	342-350	transition protein 2	Homo sapiens	126-129
8496938-2	1993	Antagonists of PAF containing an aromatic ring linked to a pyridinium ring.	pyridine	59-69	patchy fur	Mus musculus	15-18
8098376-7	1993	Pyridine alone had no effect on BALF or SDH but enhanced GGT and LDH release into the BALF and SDH release into the serum when compared with CCl4 exposure alone.	pyridine	0-8	gamma-glutamyltransferase 1	Rattus norvegicus	57-60
8098376-8	1993	Evaluation of the liver at the light microscopic level revealed characteristic CCl4-induced centrilobular necrosis which was potentiated by pyridine.	pyridine	140-148	C-C motif chemokine ligand 4	Rattus norvegicus	79-83
8098376-12	1993	Induction of cytochrome P450IIE1 by pyridine increases the bioactivation of CCl4 in both the liver and lung, leading to enhanced toxicity.	pyridine	36-44	C-C motif chemokine ligand 4	Rattus norvegicus	76-80
1457601-2	1992	Pyridine (200 mg/kg) increased total cytochrome P-450 content and activated metabolism of some specific substrates 24 hours after injection.	pyridine	0-8	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	37-53
1457601-8	1992	Hence, pyridine and its derivative pyridine-N-oxide can be regarded as effective inducers of cytochrome P-450.	pyridine	7-15	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	93-109
1385952-0	1992	Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2).	pyridine	32-42	NAD(P)H quinone dehydrogenase 1	Homo sapiens	94-107
1641061-6	1992	The conversion of MPTP to its corresponding pyridinium-ion derivative through the action of MAO-B is known to be essential for its neurotoxicity.	pyridine	44-54	monoamine oxidase B	Homo sapiens	92-97
1641061-8	1992	Studies of the changes in absorbance spectra during the MAO-B catalysed oxidation were consistent with the formation of the corresponding pyridinium-ion derivative (MPP+), which is known to be the effective neurotoxin, as the end-product when MPTP was oxidized.	pyridine	138-148	monoamine oxidase B	Homo sapiens	56-61
1641061-9	1992	In contrast the oxidation of PTP appeared to stop at the dihydropyridine stage with no significant further oxidation to the corresponding pyridine-derivative.	pyridine	64-72	protein tyrosine phosphatase receptor type U	Homo sapiens	29-32
1358578-7	1992	Induction of rat hepatic microsomal epoxide hydrolase activity by some pyridine-containing compounds appears coordinately regulated with glucuronidation rather than oxidation enzymes.	pyridine	71-79	epoxide hydrolase 1	Rattus norvegicus	25-53
1379807-0	1992	Evidence for elevation of cytochrome P4502E1 (alcohol-inducible form) mRNA levels in rat kidney following pyridine administration.	pyridine	106-114	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	26-44
1379807-1	1992	The effects of pyridine on renal cytochrome P4502E1 (CYP2E1) expression in rat have been examined by immunoblot and Northern blot analyses.	pyridine	15-23	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	33-51
1379807-1	1992	The effects of pyridine on renal cytochrome P4502E1 (CYP2E1) expression in rat have been examined by immunoblot and Northern blot analyses.	pyridine	15-23	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	53-59
1379807-5	1992	These results show that pyridine induced CYP2E1 in kidney and that elevation of renal 2E1 protein levels accompanying pyridine administration occurred at least partly as a consequence of increased 2E1 poly(A)+ RNA levels.	pyridine	24-32	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	41-47
1385952-2	1992	We have shown that the intact NAD(P)H molecule is not required and that other reduced pyridinium compounds can also act as co-factors for DT diaphorase.	pyridine	86-96	NAD(P)H quinone dehydrogenase 1	Homo sapiens	138-151
1599503-2	1992	We examined the abilities of 4-, 3- and 2-benzylpyridine and 4-tert-butylpyridine to induce hepatic microsomal cytochrome P450 and drug-metabolizing enzymes in male and female rats in order to define the effects of pyridine-containing compounds on drug metabolism.	pyridine	48-56	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	111-126
1610360-3	1992	The catalytic activity and immunoreactive protein of CYP2B recognized by polyclonal antibodies were significantly induced by a relatively high dose of pyridine (250 mg/kg, i.p.)	pyridine	151-159	cytochrome P450 family 2 subfamily B member 7, pseudogene	Homo sapiens	53-58
1610360-5	1992	Unlike CYP2E1 induction without changing its mRNA level, the induction of CYP2B by pyridine was accompanied by an elevation of its mRNA, indicating a pre-translational activation of this enzyme.	pyridine	83-91	cytochrome P450 family 2 subfamily B member 7, pseudogene	Homo sapiens	74-79
1599503-12	1992	These results and our previous report (Matsuura et al., Biochem Pharmacol 41: 1949-1956, 1991) clearly show that the pyridine compounds having lipophilic groups at the 4- or 3-position of the ring could be inducers of cytochrome P450.	pyridine	117-125	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	218-233
1553756-1	1992	Glutathione S-transferase (GST) expression was examined in hepatic cytosol from rats and rabbits treated with 4-picoline, pyrrole, pyridine, pyrazine, imidazole, or piperidine using enzymatic activity, SDS-PAGE, and immunoblot analyses and the results were compared to those obtained with phenobarbital and 3-methylcholanthrene.	pyridine	131-139	hematopoietic prostaglandin D synthase	Rattus norvegicus	0-25
1553756-1	1992	Glutathione S-transferase (GST) expression was examined in hepatic cytosol from rats and rabbits treated with 4-picoline, pyrrole, pyridine, pyrazine, imidazole, or piperidine using enzymatic activity, SDS-PAGE, and immunoblot analyses and the results were compared to those obtained with phenobarbital and 3-methylcholanthrene.	pyridine	131-139	hematopoietic prostaglandin D synthase	Rattus norvegicus	27-30
1553756-7	1992	In addition, SDS-PAGE and immunoblot analyses showed that treatment of rabbits with pyrrole, pyrazine, imidazole, or piperidine resulted in the disappearance of this class alpha 29-kDa GST band with no detectable expression of the class alpha 28-kDa GST band; the level of the class alpha 29-kDa band was unaffected by pyridine treatment.	pyridine	319-327	hematopoietic prostaglandin D synthase	Rattus norvegicus	185-188
2061924-1	1991	A series of 21 different 4-substituted 2,6-dimethyl-3-(alkoxycarbonyl)-1,4-dihydropyridines was considered with regard to oxidation to pyridine derivatives by human liver microsomal cytochrome P-450 (P-450).	pyridine	82-90	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	182-198
1553756-8	1992	In contrast, immunoblot analyses of hepatic cytosol revealed that a 25.5-kDa class mu GST band disappeared following treatment with pyridine, but was unaffected by treatment with other nitrogen heterocycles.	pyridine	132-140	hematopoietic prostaglandin D synthase	Rattus norvegicus	86-89
1769127-1	1991	OBJECTIVE: The aim was to study the effect of growth hormone (GH) on new markers of bone resorption (fasting urinary excretion of pyridinium cross-links (pyridinoline and deoxypyridinoline)) in GH-deficient adults.	pyridine	130-140	growth hormone 1	Homo sapiens	46-60
1769127-1	1991	OBJECTIVE: The aim was to study the effect of growth hormone (GH) on new markers of bone resorption (fasting urinary excretion of pyridinium cross-links (pyridinoline and deoxypyridinoline)) in GH-deficient adults.	pyridine	130-140	growth hormone 1	Homo sapiens	62-64
2125822-0	1990	Bovine lens aldose reductase: tight binding of the pyridine coenzyme.	pyridine	51-59	aldose reductase	Bos taurus	12-28
2002459-2	1991	Opening the pyrimidine or pyridine ring of EHNA or 3-deaza-EHNA respectively led to compounds which are still ADA inhibitors.	pyridine	26-34	adenosine deaminase	Homo sapiens	110-113
1912294-1	1991	Evidence that partially oxidized piperidine derivatives such as the Parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are biotransformed in a reaction catalyzed by monoamine oxidase B (MAO-B) to neurotoxic pyridinium metabolites led to studies resulting in the identification of the haloperidol-derived pyridinium metabolite in the urine of drug-treated rats.	pyridine	236-246	monoamine oxidase B	Rattus norvegicus	194-213
1912294-1	1991	Evidence that partially oxidized piperidine derivatives such as the Parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are biotransformed in a reaction catalyzed by monoamine oxidase B (MAO-B) to neurotoxic pyridinium metabolites led to studies resulting in the identification of the haloperidol-derived pyridinium metabolite in the urine of drug-treated rats.	pyridine	236-246	monoamine oxidase B	Rattus norvegicus	215-220
1912294-1	1991	Evidence that partially oxidized piperidine derivatives such as the Parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are biotransformed in a reaction catalyzed by monoamine oxidase B (MAO-B) to neurotoxic pyridinium metabolites led to studies resulting in the identification of the haloperidol-derived pyridinium metabolite in the urine of drug-treated rats.	pyridine	333-343	monoamine oxidase B	Rattus norvegicus	194-213
1912294-1	1991	Evidence that partially oxidized piperidine derivatives such as the Parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are biotransformed in a reaction catalyzed by monoamine oxidase B (MAO-B) to neurotoxic pyridinium metabolites led to studies resulting in the identification of the haloperidol-derived pyridinium metabolite in the urine of drug-treated rats.	pyridine	333-343	monoamine oxidase B	Rattus norvegicus	215-220
2016263-8	1991	These results suggest that in the complex of the enzyme with NADP+ the pyridine moiety is located in the vicinity of C(4 alpha)-C(4) region and that the pi-electron density of the 4 alpha-position of flavin is decreased in the enzyme-NADP+ complex.	pyridine	71-79	complement C4	Bos taurus	117-126
2126479-4	1990	Both 3-AP and another pyridine neurotoxin, 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP), potently inhibited in vitro MAOB activity and in contrast weakly inhibited MAOA activity.	pyridine	22-30	monoamine oxidase B	Rattus norvegicus	125-129
2126479-4	1990	Both 3-AP and another pyridine neurotoxin, 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP), potently inhibited in vitro MAOB activity and in contrast weakly inhibited MAOA activity.	pyridine	22-30	monoamine oxidase A	Rattus norvegicus	172-176
2384758-2	1990	MPTP and its analogues are known to be metabolized by monoamine oxidase (MAO) to dihydropyridinium intermediates which are further transformed, either enzymatically or spontaneously, into pyridinium species.	pyridine	88-98	monoamine oxidase A	Rattus norvegicus	54-71
2384758-2	1990	MPTP and its analogues are known to be metabolized by monoamine oxidase (MAO) to dihydropyridinium intermediates which are further transformed, either enzymatically or spontaneously, into pyridinium species.	pyridine	88-98	monoamine oxidase A	Rattus norvegicus	73-76
2384758-10	1990	There was also a parallel between the capacity of clorgyline and pargyline, irreversible MAO inhibitors, to decrease the formation of the pyridinium species and their capacity to protect against the toxic actions of the tetrahydropyridines.	pyridine	138-148	monoamine oxidase A	Rattus norvegicus	89-92
2384758-11	1990	These data are consistent with the concept that the MAO-A-dependent formation of the pyridinium species from the tetrahydropyridine is a prerequisite for toxicity in PC12 cells.	pyridine	85-95	monoamine oxidase A	Rattus norvegicus	52-57
2341826-3	1990	The oral plasma clearance of nifedipine was 1189 +/- 876 ml min-1, and the mean plasma half-life (t1/2) was 5.99 +/- 3.05 h. The pyridine metabolite was not retained.	pyridine	129-137	CD59 molecule (CD59 blood group)	Homo sapiens	60-65
2126460-2	1990	Residue Asn313 is involved together with the carboxyamide moiety of the nicotinamide ring in a complex network of hydrogen bonding interactions which fix the position of the pyridinium ring of NAD to which hydride transfer occurs at the C-4 position in the catalytic reaction.	pyridine	174-184	complement C4A (Rodgers blood group)	Homo sapiens	237-240
2335192-5	1990	Among the tested compounds two pyridinium analogs, 1-methyl-4-(4"-acetamidophenyl)pyridinium (MACPP+) and 1-methyl-4-cyclohexylpyridinium (MCP+) were found to be selectively toxic toward dopaminergic neurons.	pyridine	31-41	CD46 molecule	Homo sapiens	139-142
1968335-0	1990	Induction of rat hepatic P450IIE1 (CYP 2E1) by pyridine: evidence for a role of protein synthesis in the absence of transcriptional activation.	pyridine	47-55	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	35-42
33765486-5	2021	The crystal structure of compound 11 bound to BACE1 confirmed van der Waals interactions between the fluorine on the pyridine and Tyr71 in the flap.	pyridine	117-125	beta-secretase 1	Canis lupus familiaris	46-51
2311261-1	1990	Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide, pyridine, and structurally related compounds.	pyridine	85-93	nicotinamide N-methyltransferase	Homo sapiens	0-32
2311261-1	1990	Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide, pyridine, and structurally related compounds.	pyridine	85-93	nicotinamide N-methyltransferase	Homo sapiens	34-38
2311261-11	1990	It will now be possible to test the hypothesis that individual differences in hepatic NNMT activity might be related to variation in the N-methylation of pyridine compounds and to individual differences in either toxicity or the therapeutic efficacy of such compounds.	pyridine	154-162	nicotinamide N-methyltransferase	Homo sapiens	86-90
1966804-3	1990	Structural analogues of platelet-activating factor (PAF, 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine) in which the acetyl group and the polar head have been replaced by ethyl and a pyridine ring, respectively, were tested for biological activities on blood platelets in vitro.	pyridine	186-194	PCNA clamp associated factor	Homo sapiens	24-50
1966804-3	1990	Structural analogues of platelet-activating factor (PAF, 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine) in which the acetyl group and the polar head have been replaced by ethyl and a pyridine ring, respectively, were tested for biological activities on blood platelets in vitro.	pyridine	186-194	PCNA clamp associated factor	Homo sapiens	52-55
33780054-3	2021	The studied catalyst systems generate low-spin ( S  = 1/2) oxoiron(V) intermediates or high-spin ( S  = 3/2) oxoiron(V) intermediates, depending on the electron-donating ability of remote substituents at the pyridine rings.	pyridine	208-216	spindlin 1	Homo sapiens	92-96
33798847-0	2021	Discovery of pyridine- sulfonamide hybrids as a new scaffold for the development of potential VEGFR-2 inhibitors and apoptosis inducers.	pyridine	13-21	kinase insert domain receptor	Homo sapiens	94-101
33944777-2	2021	We designed and synthesized fluorescent conjugates of styryl derivative with pyridine to serve as substrates of SARM1, which exhibited large red-shifts after conversion.	pyridine	77-85	sterile alpha and HEAT/Armadillo motif containing 1	Mus musculus	112-117
32891000-0	2020	Pyridinium derivatives of 3-aminobenzenesulfonamide are nanomolar-potent inhibitors of tumor-expressed carbonic anhydrase isozymes CA IX and CA XII.	pyridine	0-10	carbonic anhydrase 9	Homo sapiens	131-136
32891000-0	2020	Pyridinium derivatives of 3-aminobenzenesulfonamide are nanomolar-potent inhibitors of tumor-expressed carbonic anhydrase isozymes CA IX and CA XII.	pyridine	0-10	carbonic anhydrase 12	Homo sapiens	141-147
34958513-2	2022	Phosphomannose isomerase (PMI) with His-tag was successfully immobilized on Ni 2+ charged pyridine-derived particles.	pyridine	90-98	mannose phosphate isomerase	Homo sapiens	0-24
7835215-7	1994	Pretreatment of rats with pyridine and ethanol, inducers of cytochrome P450 2E1, increased the rate of fluoride formation.	pyridine	26-34	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	60-79
34979302-5	2022	The molecules with N-ethyl chains showed the greatest in vitro light-dependent cytotoxic effects, particularly the zwitterionic squaraine dye and the one bearing a single pyridine unit, which also exhibited a more significant interaction with human albumin.	pyridine	171-179	albumin	Homo sapiens	249-256
34854518-2	2022	In the present study, we found that SC66, a pyridine-based allosteric Akt inhibitor, suppressed basal and H2 O2 -induced autophagy concurrent with decreased phosphorylation and activity of AMPK.	pyridine	44-52	AKT serine/threonine kinase 1	Homo sapiens	70-73
34854518-2	2022	In the present study, we found that SC66, a pyridine-based allosteric Akt inhibitor, suppressed basal and H2 O2 -induced autophagy concurrent with decreased phosphorylation and activity of AMPK.	pyridine	44-52	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	189-193
34958513-2	2022	Phosphomannose isomerase (PMI) with His-tag was successfully immobilized on Ni 2+ charged pyridine-derived particles.	pyridine	90-98	mannose phosphate isomerase	Homo sapiens	26-29
34946648-5	2021	Under simulated sunlight irradiation (280 nm < lambda < 980 nm), SnO2@MCr demonstrated superior photoactivity toward the denitrification of pyridine, a typical NCC.	pyridine	140-148	strawberry notch homolog 1	Homo sapiens	65-68
34992411-3	2021	Emerging evidence suggests that activation of the NOD-like receptor (NLR) family and the pyridine-containing domain 3 (NLRP3) inflammasome is instrumental in inflammation and may result in AS.	pyridine	89-97	NLR family pyrin domain containing 3	Homo sapiens	119-124
34824205-1	2021	The visible light induced, photocatalysts or photoabsorbing EDA complexes mediated cleavage of pyridinium C-N bond were reported in the past years.	pyridine	95-105	ectodysplasin A	Homo sapiens	60-63
34085303-9	2021	The resulting 15 N polarization (maximal value about 4% achieved for metronidazole and pyridine at 45 o C degree) strongly depends on the sample temperature, pH2 bubbling pressure and pH2 flow.	pyridine	87-95	polyhomeotic homolog 2	Homo sapiens	158-161
34085303-9	2021	The resulting 15 N polarization (maximal value about 4% achieved for metronidazole and pyridine at 45 o C degree) strongly depends on the sample temperature, pH2 bubbling pressure and pH2 flow.	pyridine	87-95	polyhomeotic homolog 2	Homo sapiens	184-187
34806099-6	2021	Using pyridine as base eliminated this dealkylation and resulted in the exclusive formation of LPd(py) complexes in high yields.	pyridine	6-14	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	95-98
34147745-0	2021	Identification of 3, 4-disubstituted pyridine derivatives as novel CDK8 inhibitors.	pyridine	37-45	cyclin-dependent kinase 8	Mus musculus	67-71
34917239-0	2021	Amide-Substituted Condensed Pyridine Derivatives as ACSS2 Inhibitors for Treating Cancer.	pyridine	28-36	acyl-CoA synthetase short chain family member 2	Homo sapiens	52-57
34420225-2	2021	These sigma-complexes originate from the unique combination of 12 stannylenes (SnX2 ) with five azabenzene ligands (pyridine, pyrazine, pyrimidine, pyridazine, and s-triazine), where the nitrogen center of the ligand acts as sigma-donor and the tin(II) center as sigma-acceptor in a 1:1 fashion.	pyridine	96-106	sorting nexin 2	Homo sapiens	79-83
34420225-2	2021	These sigma-complexes originate from the unique combination of 12 stannylenes (SnX2 ) with five azabenzene ligands (pyridine, pyrazine, pyrimidine, pyridazine, and s-triazine), where the nitrogen center of the ligand acts as sigma-donor and the tin(II) center as sigma-acceptor in a 1:1 fashion.	pyridine	116-124	sorting nexin 2	Homo sapiens	79-83
34668910-1	2021	We have proven that pyridine-boryl complexes can be used as superelectron donors to promote the coupling of thiols and aromatic halides through a SRN1 mechanism.	pyridine	20-28	NPHS2 stomatin family member, podocin	Homo sapiens	146-150
34832958-0	2021	Inhibitory Effect of Chlorogenic Acid Analogues Comprising Pyridine and Pyrimidine on alpha-MSH-Stimulated Melanogenesis and Stability of Acyl Analogues in Methanol.	pyridine	59-67	STAM binding protein	Mus musculus	86-95
34832958-3	2021	The results illustrated that a pyridine analogue 6f and a diacyl derivative 13a of CGA showed superior inhibition profiles (IC50: 2.5 +- 0.7 muM and 1.1 +- 0.1 muM, respectively) of alpha-MSH activities than positive controls, kojic acid and arbutin (IC50: 54 +- 1.5 muM and 380 +- 9.5 muM, respectively).	pyridine	31-39	STAM binding protein	Mus musculus	182-191
34487418-4	2021	Utility is demonstrated via the three-step stereoselective preparation of pyridine-containing analogues of potent selective estrogen receptor downregulator and US FDA approved drug Tadalafil."	pyridine	74-82	estrogen receptor 1	Homo sapiens	124-141
34669416-4	2021	Binding in this congested pocket accommodates four hydrogen bond contacts among ligands and substrates, ultimately favoring a pre-syn arrangement highlighted by pyridinium-azomethine activation and quinolinium-nitronate activation.	pyridine	161-171	synemin	Homo sapiens	130-133
34147745-2	2021	A series of novel CDK8 inhibitors with the pyridine core was identified via scaffold hopping from the known CDK8 inhibitor A-7.	pyridine	43-51	cyclin-dependent kinase 8	Mus musculus	18-22
34147745-2	2021	A series of novel CDK8 inhibitors with the pyridine core was identified via scaffold hopping from the known CDK8 inhibitor A-7.	pyridine	43-51	cyclin-dependent kinase 8	Mus musculus	108-112
34536931-5	2021	The molecular dynamics simulation studies revealed that the presence of pyridine moiety of FT1 was essential and played a significant role in its binding with RT (reverse transcriptase).	pyridine	72-80	AKT interacting protein	Homo sapiens	91-94
34553947-0	2021	Discovery of Extremely Selective Fused Pyridine-Derived beta-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions.	pyridine	39-47	amyloid beta precursor protein	Homo sapiens	66-91
34745424-6	2021	In order to discover novel VEGFR-2 TK inhibitors, we have designed and synthesized three new series of pyridine-containing compounds.	pyridine	103-111	kinase insert domain receptor	Homo sapiens	27-34
34707193-2	2021	The sp2 carbon atoms adjacent to nitrogen in the pyridine ring provide pi-acceptor which forms a complex with filled d-orbital of native oxides on Cu and Ru metal film.	pyridine	49-57	Sp2 transcription factor	Homo sapiens	4-7
34427954-4	2021	The multiple rotors (pyridine and benzene ring) causes twisted conformations of the molecule that prevents pi-pi stacking and enhances solid emission(Phi TM-2 <Phi TM-3 , Phi TM-1 <Phi TM-4 ).	pyridine	21-29	tropomyosin 3	Homo sapiens	164-168
34553947-0	2021	Discovery of Extremely Selective Fused Pyridine-Derived beta-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions.	pyridine	39-47	beta-secretase 1	Homo sapiens	109-114
34553947-5	2021	By leveraging the difference, we designed fused pyridine analogues that could reach the 10s loop, leading to 6 with high selectivity and significant Abeta reduction.	pyridine	48-56	amyloid beta precursor protein	Homo sapiens	149-154
34587988-0	2021	Design, synthesis, and biological evaluation of symmetrical azine derivatives as novel tyrosinase inhibitors.	pyridine	60-65	tyrosinase	Mus musculus	87-97
34760201-0	2021	Cooperative C-H activation of pyridine by PBP complexes of Rh and Ir can lead to bridging 2-pyridyls with different connectivity to the B-M unit.	pyridine	30-38	polycystin 1, transient receptor potential channel interacting	Homo sapiens	42-45
34760201-1	2021	Pyridine and quinoline undergo selective C-H activation in the 2-position with Rh and Ir complexes of a boryl/bis(phosphine) PBP pincer ligand, resulting in a 2-pyridyl bridging the transition metal and the boron center.	pyridine	0-8	polycystin 1, transient receptor potential channel interacting	Homo sapiens	125-128
34551513-4	2021	Herein, we systematically investigate the influence of the lone pair of electrons on the interface dipole through three pyridine derivatives B2-B4PyMPM.	pyridine	120-128	immunoglobulin kappa variable 5-2	Homo sapiens	141-151
34587988-1	2021	A series of symmetrical azine derivatives containing different substituted benzyl moieties were designed, synthesized, and evaluated for their inhibitory activity against tyrosinase.	pyridine	24-29	tyrosinase	Mus musculus	171-181
34217975-0	2021	Rational design of phenyl thiophene (pyridine) derivatives that overcome P-glycoprotein mediated MDR in MCF-7/ADR cell.	pyridine	37-45	ATP binding cassette subfamily B member 1	Homo sapiens	73-87
34482880-3	2021	In this work, a pyridinium-functionalized triphenylamine derivative, (E)-4-(2-(4"-(diphenylamino)-(1,1"-biphenyl)-4-yl)vinyl)-1-methylpyridin-1-ium iodide (Mito-I), was exploited as photosensitizer for mitochondria-targeted photodynamic therapy and as fluorescent probe for imaging the mitochondrial viscosity dynamic during mitophagy simultaneously.	pyridine	16-26	ubiquitination factor E4A	Homo sapiens	69-74
34378958-15	2021	In this study, we identified an aldehyde dehydrogenase responsible for the oxidation of 6-hydroxy-3-succinoyl-semialdehyde-pyridine to 6-hydroxy-3-succinoylpyridine; this was the only uncharacterized enzyme in the hybrid of the pyridine and pyrrolidine pathways in Agrobacterium tumefaciens S33.	pyridine	228-236	AWN88_RS16050	Agrobacterium tumefaciens	32-54
34229201-4	2021	Analysis of IC50 data revealed a structure-activity relationship, which is that the pyridine and hydroxylbenzene substituents at 2-position improved inhibition of the compounds on NDM-1.	pyridine	84-92	NDM-1	Klebsiella pneumoniae	180-185
34484564-1	2021	The original Laminaria polysaccharide (LP0) was sulfated using the sulfur trioxide-pyridine method, and four sulfated Laminaria polysaccharides (SLPs) were obtained, namely, SLP1, SLP2, SLP3, and SLP4.	pyridine	83-91	ribosomal protein lateral stalk subunit P0	Homo sapiens	39-42
34324612-1	2021	In order to prepare a multifunctional magnetic material combining spin crossover together with single-molecular magnetism, co-crystallization of Fe(ii) and Co(ii) complexes of the pyridine derivative of cyclam (Py2-C = 1,8-bis(pyridin-2-ylmethyl)-1,4,8,11-tetraazacyclotetradecane) was performed.	pyridine	180-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
34577562-4	2021	A significant increase of P-gp inhibitory activity was observed for most derivatives, mainly those containing azine moieties with aromatic substituents.	pyridine	110-115	phosphoglycolate phosphatase	Homo sapiens	26-30
34235338-2	2021	Complexation of Fe(BF4)2 6H2O with each ligand (H2 L1 and H4 L2) in a methanolic-pyridine solution resulted in hexa-iron compounds (C1 and C2, respectively), which each contain two near-parallel metal triangles of (Fe3-mu3-O), linked by six fluoride bridges and stabilized by a hydrogen-bonded proton between the mu3-O groups.	pyridine	81-89	hexosaminidase subunit alpha	Homo sapiens	111-115
34298950-4	2021	In this study, we identified pyridine derivatives by evaluating in vitro TNKS enzyme activity and investigated N-((1,2,4)triazolo(4,3-a)pyridin-3-yl)-1-(2-cyanophenyl)piperidine-4-carboxamide (TI-12403) as a novel TNKS inhibitor.	pyridine	29-37	tankyrase	Homo sapiens	73-77
34298950-4	2021	In this study, we identified pyridine derivatives by evaluating in vitro TNKS enzyme activity and investigated N-((1,2,4)triazolo(4,3-a)pyridin-3-yl)-1-(2-cyanophenyl)piperidine-4-carboxamide (TI-12403) as a novel TNKS inhibitor.	pyridine	29-37	tankyrase	Homo sapiens	214-218
34139681-6	2021	The high activity is ascribed to the large specific surface area (SSA), porous structure and the synergistic effect between S, F, pyridine N, graphite N and Fe-Nx.	pyridine	130-138	general transcription factor IIE subunit 1	Homo sapiens	157-159
34206976-0	2021	Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity.	pyridine	53-61	cyclin dependent kinase 2	Homo sapiens	77-81
34267885-0	2021	Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors.	pyridine	62-70	indoleamine 2,3-dioxygenase 1	Mus musculus	71-75
34467293-1	2021	A series of D-pi-A + pyridinium compounds, in which D = -NPh2 and A+ = -PyMe+ are linked by various amounts of linear phenyl spacers, were strategically designed and synthesized.	pyridine	21-31	neurexophilin 2	Homo sapiens	57-61
35439688-2	2022	From a previously disclosed 5-azaquinazoline series, we found that switching the pyridine ring for an N-substituted pyridone gave a novel hinge binding scaffold which retained potency against IRAK4.	pyridine	81-89	interleukin 1 receptor associated kinase 4	Homo sapiens	192-197
35346844-0	2022	Design, synthesis and biological evaluation of novel pyridine derivatives as gut-selective NaPi2b inhibitors.	pyridine	53-61	solute carrier family 34 member 2	Rattus norvegicus	91-97
35346844-4	2022	In this report, we identified novel pyridine derivatives as gut-selective NaPi2b inhibitors with good activity in vitro and relatively low hydrophobicity.	pyridine	36-44	solute carrier family 34 member 2	Rattus norvegicus	74-80
35576656-2	2022	However, a risk of on-target side effects based on the inhibition of NaPi2b in the lung and testis has been reported.In this article, we report on our identification of novel indole derivatives as gut-selective NaPi2b inhibitors with good activity, low systemic exposure and moderate hydrophobicity.In particular, gut-selective compound 27, with even lower bioavailability and lower systemic exposure as compared to previously reported pyridine derivatives, demonstrated excellent phosphate absorption-inhibitory effect in SD rats.	pyridine	436-444	solute carrier family 34 member 2	Rattus norvegicus	211-217
35623140-0	2022	Novel Azine Linked Hybrids of 2-Indolinone and Thiazolodinone Scaffolds as CDK2 Inhibitors with Potential Anticancer Activity: In Silico Design, Synthesis, Biological, Molecular Dynamics and Binding Free Energy Studies.	pyridine	6-11	cyclin dependent kinase 2	Homo sapiens	75-79
35465672-3	2022	Herein, a two-dimensional Fe-Ni MOF of Fe(py)2Ni(CN)4 (py = pyridine) is synthesized controllably to generate various nanostructures, including nanoboxes, nanocubes, nanoplates, and nanosheets.	pyridine	60-68	lysine acetyltransferase 8	Homo sapiens	32-35
35500109-3	2022	Here, we proposed a simple strategy for the preparation of a heterogeneous photocatalyst suitable for photo induced atom transfer radical polymerization (photoATRP) under full spectrum (from UV/vis light to NIR), by combining pyridine nitrogen doped carbon dots (N-CDs) and upconversion nanoparticles (UCNPs).	pyridine	226-234	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	207-210
35586808-0	2022	Design, Synthesis and Activity Study of Pyridine Derivatives as Highly Effective and Selective TYK2 Inhibitors.	pyridine	40-48	tyrosine kinase 2	Homo sapiens	95-99
35014678-0	2022	A pyridinium-type fullerene derivative suppresses primary effusion lymphoma cell viability via the downregulation of the Wnt signaling pathway through the destabilization of beta-catenin.	pyridine	2-12	catenin beta 1	Homo sapiens	174-186
35417165-3	2022	Further evaluations showed that this enhanced Ln-contraction also occurs for pyridine (py) in the (Ln(SST)3(py)2) family as well as the average Ln-N(py) (La vs Lu) structure distances recovered from the CSD.	pyridine	77-85	sushi, nidogen and EGF like domains 1	Homo sapiens	102-107
35417165-3	2022	Further evaluations showed that this enhanced Ln-contraction also occurs for pyridine (py) in the (Ln(SST)3(py)2) family as well as the average Ln-N(py) (La vs Lu) structure distances recovered from the CSD.	pyridine	87-89	sushi, nidogen and EGF like domains 1	Homo sapiens	102-107
35138016-4	2022	Furthermore, the addition of another Lewis base - Triethylamine to Lewis acid-base pair brought the electrical properties back to that of single DBP junction, which establishs a basic understanding in the design and construction of reversible and controllable molecular device based on pyridine derived molecule.	pyridine	286-294	D-box binding PAR bZIP transcription factor	Homo sapiens	145-148
35437010-5	2022	The addition reaction of t-ethynyl-SF4-pyridines to the carbonyl group in the presence of MeLi smoothly afforded pyridine-SF4-propargylic tertiary and secondary alcohols in high yields.	pyridine	113-121	SURP and G-patch domain containing 1	Homo sapiens	35-38
35437010-5	2022	The addition reaction of t-ethynyl-SF4-pyridines to the carbonyl group in the presence of MeLi smoothly afforded pyridine-SF4-propargylic tertiary and secondary alcohols in high yields.	pyridine	113-121	SURP and G-patch domain containing 1	Homo sapiens	122-125
35229099-3	2022	Three amines, i-Pr2NEt, Me2NBn, or N-ethylmorpholine, were used with pyridine in accordance with the steric bulkiness of a side chain in the alpha-amino acid N-carboxyanhydride.	pyridine	69-77	nibrin	Homo sapiens	27-30
35286077-6	2022	The products isolated from reactions undertaken in pyridine (py) were identified as (Ln(SST)3(py)2) (Ln-py = Ce-py, Eu-py, and Tm-py).	pyridine	51-59	sushi, nidogen and EGF like domains 1	Homo sapiens	88-93
35286077-6	2022	The products isolated from reactions undertaken in pyridine (py) were identified as (Ln(SST)3(py)2) (Ln-py = Ce-py, Eu-py, and Tm-py).	pyridine	61-63	sushi, nidogen and EGF like domains 1	Homo sapiens	88-93
35076038-2	2022	NMR spectral evidence indicated that the meso-methyl group and BF2 core of BODIPYs formed C-H N and C-H F-B pseudo-hydrogen bonds with pyridine, respectively.	pyridine	135-143	forkhead box G1	Homo sapiens	63-66
35155923-1	2022	3-Acyl imidazo(1,5-a)pyridines, featured pharmaceutical moieties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp3 (C-H) double amination of acetophenones with pyridine ethylamines using ammonium iodide as a redox mediator.	pyridine	233-241	Sp3 transcription factor	Homo sapiens	184-187
35250440-6	2022	Results: All MCS patients showed behavioral responses to the 1-Octen-3-ol stimulus; nine MCS and one UWS showed olfactory emotional responses to the pyridine, and two MCS showed olfactory emotional responses to the water stimulus.	pyridine	149-157	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	89-92
35135455-2	2022	Without affecting the cytosolic isoforms hCA I and II, inhibition of two membrane-associated isoforms hCA IX and XII especially over-expressed in hypoxic tumour cells, makes the pyridinium derivatives potent promising therapeutic agents.	pyridine	178-188	carbonic anhydrase 9	Homo sapiens	102-116
35060702-1	2022	2,5-Dihydroxypyridine dioxygenase (NicX) from Pseudomonas putida KT2440 is a mononuclear non-heme iron oxygenase that can catalyze the oxidative pyridine ring cleavage.	pyridine	145-153	2,5-dihydroxypyridine 5,6-dioxygenase	Pseudomonas putida KT2440	35-39
35060702-5	2022	The NicX-catalyzed pyridine ring degradation contains three parts, including the attack of Fe(II)-superoxo on the activated pyridine ring, the dissociation of the Op-Od bond, and the ring-opening of the seven-membered-ring lactone.	pyridine	19-27	2,5-dihydroxypyridine 5,6-dioxygenase	Pseudomonas putida KT2440	4-8
35060702-5	2022	The NicX-catalyzed pyridine ring degradation contains three parts, including the attack of Fe(II)-superoxo on the activated pyridine ring, the dissociation of the Op-Od bond, and the ring-opening of the seven-membered-ring lactone.	pyridine	124-132	2,5-dihydroxypyridine 5,6-dioxygenase	Pseudomonas putida KT2440	4-8
35056841-3	2022	By the installing of a cyano-group on pyridine scaffold, the proton donating ability of -NH2 was greatly enhanced, enabling 2-APC to undergo ESIPT-e process.	pyridine	38-46	APC regulator of WNT signaling pathway	Homo sapiens	126-129
35221376-2	2022	In vitro studies revealed that the phenyl moiety of donepezil can be successfully replaced with a pyridine ring leading to equally potent inhibitors of electric eel AChE.	pyridine	98-106	acetylcholinesterase (Cartwright blood group)	Homo sapiens	165-169