PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19296261-12	2009	Compared with DSS group, balsalazide improved gross findings, decreased MPO activity and MDA content, but increased the activity of SOD and GSH-PX(P<0.05).	balsalazide	25-36	myeloperoxidase	Mus musculus	72-75
34984721-4	2022	Balsalazide is acting as a peroxisome proliferator-activated receptors (PPARgamma).	balsalazide	0-11	peroxisome proliferator activated receptor gamma	Mus musculus	72-81
28108625-0	2017	Combined Parthenolide and Balsalazide Have Enhanced Antitumor Efficacy Through Blockade of NF-kappaB Activation.	balsalazide	26-37	nuclear factor kappa B subunit 1	Homo sapiens	91-100
28108625-4	2017	The results demonstrate that the combination of balsalazide and parthenolide markedly suppress proliferation, nuclear translocation of NF-kappaB, IkappaB-alpha phosphorylation, NF-kappaB DNA binding, and expression of NF-kappaB targets.	balsalazide	48-59	nuclear factor kappa B subunit 1	Homo sapiens	135-144
28108625-4	2017	The results demonstrate that the combination of balsalazide and parthenolide markedly suppress proliferation, nuclear translocation of NF-kappaB, IkappaB-alpha phosphorylation, NF-kappaB DNA binding, and expression of NF-kappaB targets.	balsalazide	48-59	NFKB inhibitor alpha	Homo sapiens	146-159
28108625-4	2017	The results demonstrate that the combination of balsalazide and parthenolide markedly suppress proliferation, nuclear translocation of NF-kappaB, IkappaB-alpha phosphorylation, NF-kappaB DNA binding, and expression of NF-kappaB targets.	balsalazide	48-59	nuclear factor kappa B subunit 1	Homo sapiens	177-186
28108625-4	2017	The results demonstrate that the combination of balsalazide and parthenolide markedly suppress proliferation, nuclear translocation of NF-kappaB, IkappaB-alpha phosphorylation, NF-kappaB DNA binding, and expression of NF-kappaB targets.	balsalazide	48-59	nuclear factor kappa B subunit 1	Homo sapiens	177-186
28108625-8	2017	These results demonstrate that parthenolide potentiates the efficacy of balsalazide through synergistic inhibition of NF-kappaB activation and the combination of dual agents prevents colon carcinogenesis from chronic inflammation.	balsalazide	72-83	nuclear factor kappa B subunit 1	Homo sapiens	118-127
24467436-16	2014	NAT inhibitors for co-administration with 5-aminosalicylate (5-AS) in inflammatory bowel disease has prompted ongoing investigations of azoreductases in gut bacteria which release 5-AS from prodrugs including balsalazide.	balsalazide	209-220	bromodomain containing 2	Homo sapiens	0-3
19575002-8	2009	RESULTS: Balsalazine was found to reduce the DAI score and the histological index (HI) score, decrease the MDA content and the activity of MPO, and increase the activity of SOD and GSH-Px in colitis mice.	balsalazide	9-20	myeloperoxidase	Mus musculus	139-142
19575002-9	2009	At the same time, balsalazine ameliorated microvillus and tight junction structure, resulting in a decrease in the amount of Evans blue permeating into the intestinal wall and the levels of TNF-alpha and IFN-gamma in colitis mice.	balsalazide	18-29	tumor necrosis factor	Mus musculus	190-199
19575002-9	2009	At the same time, balsalazine ameliorated microvillus and tight junction structure, resulting in a decrease in the amount of Evans blue permeating into the intestinal wall and the levels of TNF-alpha and IFN-gamma in colitis mice.	balsalazide	18-29	interferon gamma	Mus musculus	204-213
12650813-0	2003	Treatment of ulcerative colitis with balsalazide: response to Drs Johnson, Green, and Pruitt.	balsalazide	37-48	sushi repeat containing protein X-linked	Homo sapiens	62-65
12526969-0	2003	Treatment of ulcerative colitis with balsalazide: response to editorial by Drs.	balsalazide	37-48	sushi repeat containing protein X-linked	Homo sapiens	75-78
26711554-0	2016	Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3.	balsalazide	93-104	interleukin 6	Mus musculus	71-75
26711554-0	2016	Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3.	balsalazide	93-104	signal transducer and activator of transcription 3	Mus musculus	76-81
19155731-8	2009	Medications associated with PPD are reviewed and the patient"s use of mesalamine and balsalazide for ulcerative colitis are deemed potential triggers, given their relative similarity to aspirin, a known trigger of PPD.	balsalazide	85-96	cellular communication network factor 6	Homo sapiens	214-217