PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16781459-5	2006	Moreover, NO production in LPS-stimulated macrophages that are expressing CSE mRNA was significantly reduced by the addition of L-Cys, a substrate for H(2)S, but enhanced by the selective CSE inhibitor beta-cyano-L-alanine but not by the CBS inhibitor aminooxyacetic acid.	Aminooxyacetic Acid	252-271	cystathionine gamma-lyase	Homo sapiens	74-77
18201837-11	2008	Infusion of the CBS inhibitors aminooxyacetic acid (10 mM) and hydroxylamine (20 mM) increased MAP but did not block the effects of infusion of 200 microM NaHS.	Aminooxyacetic Acid	31-50	cystathionine beta synthase	Rattus norvegicus	16-19
17468001-6	2007	Expression of CsHA1, CsFRO1 and CsIRT1 is diminished in Fe-deficient roots by treatment with ethylene inhibitors, like Co (cobalt) or AOA (aminooxyacetic acid).	Aminooxyacetic Acid	134-137	plasma membrane ATPase 4	Cucumis sativus	14-19
17468001-6	2007	Expression of CsHA1, CsFRO1 and CsIRT1 is diminished in Fe-deficient roots by treatment with ethylene inhibitors, like Co (cobalt) or AOA (aminooxyacetic acid).	Aminooxyacetic Acid	139-158	plasma membrane ATPase 4	Cucumis sativus	14-19
17101327-8	2006	The endogenous H(2)S donor L-cysteine also induced secretion that was diminished significantly by capsaicin desensitization, the CBS inhibitor amino-oxyacetic acid, and the CSE inhibitor propargylglycine.	Aminooxyacetic Acid	143-163	cystathionine beta-synthase	Homo sapiens	129-132
16028113-5	2005	The hypoxic induction of ACS9 is inhibited by aminooxy acetic acid, an inhibitor of ethylene biosynthesis.	Aminooxyacetic Acid	46-66	1-aminocyclopropane-1-carboxylate synthase 9	Arabidopsis thaliana	25-29
16516347-4	2006	The presence of aminooxyacetic acid (AOAA, 10 microM) which inhibits transaminases and other pyridoxal phosphate dependent enzymes including GABA-transaminase (GABA-T), in the culture medium caused an increase in the intracellular amount of GABA and a decrease in glutamate.	Aminooxyacetic Acid	16-35	4-aminobutyrate aminotransferase	Mus musculus	141-158
16516347-4	2006	The presence of aminooxyacetic acid (AOAA, 10 microM) which inhibits transaminases and other pyridoxal phosphate dependent enzymes including GABA-transaminase (GABA-T), in the culture medium caused an increase in the intracellular amount of GABA and a decrease in glutamate.	Aminooxyacetic Acid	16-35	4-aminobutyrate aminotransferase	Mus musculus	160-166
16516347-4	2006	The presence of aminooxyacetic acid (AOAA, 10 microM) which inhibits transaminases and other pyridoxal phosphate dependent enzymes including GABA-transaminase (GABA-T), in the culture medium caused an increase in the intracellular amount of GABA and a decrease in glutamate.	Aminooxyacetic Acid	37-41	4-aminobutyrate aminotransferase	Mus musculus	141-158
16516347-4	2006	The presence of aminooxyacetic acid (AOAA, 10 microM) which inhibits transaminases and other pyridoxal phosphate dependent enzymes including GABA-transaminase (GABA-T), in the culture medium caused an increase in the intracellular amount of GABA and a decrease in glutamate.	Aminooxyacetic Acid	37-41	4-aminobutyrate aminotransferase	Mus musculus	160-166
15880762-5	2005	Neuronal and astrocytic synthesis alike were vulnerable to inhibition exerted by the aminotransferase inhibitor aminooxyacetic acid (AOAA), glutamate (IC50: 31 and 85 microM, respectively), substrates of the L-amino transport system [leucine (Leu); IC50: 19 and 42 microM, respectively] and 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH; IC50: 19 and 28 microM, respectively).	Aminooxyacetic Acid	112-131	chimerin 2	Homo sapiens	339-342
15880762-5	2005	Neuronal and astrocytic synthesis alike were vulnerable to inhibition exerted by the aminotransferase inhibitor aminooxyacetic acid (AOAA), glutamate (IC50: 31 and 85 microM, respectively), substrates of the L-amino transport system [leucine (Leu); IC50: 19 and 42 microM, respectively] and 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH; IC50: 19 and 28 microM, respectively).	Aminooxyacetic Acid	133-137	chimerin 2	Homo sapiens	339-342
16462202-9	2006	This effect of cysteine was abolished by aminooxyacetic acid, an inhibitor of the enzyme cystathionine beta-synthase that converts cysteine to hydrogen sulfide (H2S), indicating that this novel neuromodulator may be acting as a mediator of ischemic brain damage.	Aminooxyacetic Acid	41-60	cystathionine beta-synthase	Homo sapiens	89-116
16289454-1	2005	To elucidate the effect of an inhibitor of pyridoxal phosphate-dependent enzymes, aminooxyacetic acid, on the activity of serine racemase in vivo, we have investigated the effect of aminooxyacetic acid on the extracellular concentration of D-serine in the rat striatum using an in vivo microdialysis technique.	Aminooxyacetic Acid	82-101	serine racemase	Rattus norvegicus	122-137
16289454-3	2005	These data, together with the fact that serine racemase is a pyridoxal phosphate-dependent enzyme, suggest that the aminooxyacetic acid-induced reduction of the extracellular D-serine may be at least in part due to the drug"s ability to inhibit serine racemase.	Aminooxyacetic Acid	116-135	serine racemase	Rattus norvegicus	40-55
16289454-3	2005	These data, together with the fact that serine racemase is a pyridoxal phosphate-dependent enzyme, suggest that the aminooxyacetic acid-induced reduction of the extracellular D-serine may be at least in part due to the drug"s ability to inhibit serine racemase.	Aminooxyacetic Acid	116-135	serine racemase	Rattus norvegicus	245-260
14998680-7	2004	Ethacrynic acid (EA), an inhibitor of glutathione S-transferase (GST) that catalyses GSH-substrate conjugation, also enhanced the cytolethality of MMAs(V), but aminooxyacetic acid (AOAA), an inhibitor of beta-lyase that catalyses the final breakdown of GSH-substrate conjugates, had no effect.	Aminooxyacetic Acid	181-185	glutathione S-transferase kappa 1	Homo sapiens	65-68
12899834-4	2003	In order to gain further insights into the mechanistic link between genotype and enzymatic phenotype in PH1, we have determined the crystal structure of normal human AGT complexed to the competitive inhibitor amino-oxyacetic acid to 2.5A.	Aminooxyacetic Acid	209-229	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	104-107
14578369-6	2004	Activation of caspase-3 and the cleavage of procaspase-6 and procaspase-7 were strongly inhibited by pyruvate but markedly enhanced by l-lactate and aminooxyacetate, implicating redox-related antiapoptotic mechanisms of pyruvate.	Aminooxyacetic Acid	149-164	caspase 3	Homo sapiens	14-23
12935767-8	2003	The induction and nuclear translocation of p53 by H2O2 was blocked by pyruvate and appeared to be somewhat enhanced by L-lactate or aminooxyacetate in association with oxidant generation.	Aminooxyacetic Acid	132-147	tumor protein p53	Homo sapiens	43-46
12899834-4	2003	In order to gain further insights into the mechanistic link between genotype and enzymatic phenotype in PH1, we have determined the crystal structure of normal human AGT complexed to the competitive inhibitor amino-oxyacetic acid to 2.5A.	Aminooxyacetic Acid	209-229	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	166-169
11752109-6	2002	Cysteine S-conjugate beta-lyase was inhibited by aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	49-68	kynurenine aminotransferase 1	Mus musculus	0-31
12049843-3	2002	Prior treatment of the cells with aminooxyacetic acid (AOAA), an inhibitor of the enzyme cysteine conjugate beta-lyase, afforded complete protection against the toxicity at concentrations of PCBC up to 100 microM and DCVC up to 500 microM.	Aminooxyacetic Acid	34-53	EPH receptor B2	Homo sapiens	191-195
12049843-3	2002	Prior treatment of the cells with aminooxyacetic acid (AOAA), an inhibitor of the enzyme cysteine conjugate beta-lyase, afforded complete protection against the toxicity at concentrations of PCBC up to 100 microM and DCVC up to 500 microM.	Aminooxyacetic Acid	55-59	EPH receptor B2	Homo sapiens	191-195
12049843-9	2002	The increase in [Ca(2+)](i) produced by PCBC (100 microM) was prevented by treatment with AOAA, and markedly reduced by a nominally calcium free medium or the addition of the calcium chelator EGTA.	Aminooxyacetic Acid	90-94	EPH receptor B2	Homo sapiens	40-44
11971679-6	2002	Augmenting intracellular alanine levels using the cytosolic alanine aminotransferase inhibitor, aminooxyacetic acid, increased alanine uptake activity.	Aminooxyacetic Acid	96-115	glutamic--pyruvic transaminase	Homo sapiens	60-84
11752109-6	2002	Cysteine S-conjugate beta-lyase was inhibited by aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	70-74	kynurenine aminotransferase 1	Mus musculus	0-31
11129580-6	2000	2-Aminooxyacetic acid, an inhibitor of phenylalanine ammonia-lyase (PAL), inhibited the accumulation of hydroxyanigorufone in wounded fruit, and the PAL activity increased after wounding and ethylene treatment, respectively.	Aminooxyacetic Acid	0-21	phenylalanine ammonia-lyase	Musa acuminata	68-71
11673620-2	2001	Exogenous ethylene markedly increased transcript level of VR-ACO1 and reduced that of VR-ACS1, whereas aminooxyacetic acid (AOA), an inhibitor of ethylene biosynthesis, decreased the level of VR-ACO1 mRNA and increased that of VR-ACS1, indicating that expression of VR-ACO1 and VR-ACS1 genes are under positive and negative feedback control by ethylene, respectively.	Aminooxyacetic Acid	103-122	aconitase 1	Homo sapiens	195-199
11673620-2	2001	Exogenous ethylene markedly increased transcript level of VR-ACO1 and reduced that of VR-ACS1, whereas aminooxyacetic acid (AOA), an inhibitor of ethylene biosynthesis, decreased the level of VR-ACO1 mRNA and increased that of VR-ACS1, indicating that expression of VR-ACO1 and VR-ACS1 genes are under positive and negative feedback control by ethylene, respectively.	Aminooxyacetic Acid	103-122	acyl-CoA synthetase long chain family member 1	Homo sapiens	230-234
11673620-2	2001	Exogenous ethylene markedly increased transcript level of VR-ACO1 and reduced that of VR-ACS1, whereas aminooxyacetic acid (AOA), an inhibitor of ethylene biosynthesis, decreased the level of VR-ACO1 mRNA and increased that of VR-ACS1, indicating that expression of VR-ACO1 and VR-ACS1 genes are under positive and negative feedback control by ethylene, respectively.	Aminooxyacetic Acid	103-122	aconitase 1	Homo sapiens	195-199
11673620-2	2001	Exogenous ethylene markedly increased transcript level of VR-ACO1 and reduced that of VR-ACS1, whereas aminooxyacetic acid (AOA), an inhibitor of ethylene biosynthesis, decreased the level of VR-ACO1 mRNA and increased that of VR-ACS1, indicating that expression of VR-ACO1 and VR-ACS1 genes are under positive and negative feedback control by ethylene, respectively.	Aminooxyacetic Acid	103-122	acyl-CoA synthetase long chain family member 1	Homo sapiens	230-234
11673620-2	2001	Exogenous ethylene markedly increased transcript level of VR-ACO1 and reduced that of VR-ACS1, whereas aminooxyacetic acid (AOA), an inhibitor of ethylene biosynthesis, decreased the level of VR-ACO1 mRNA and increased that of VR-ACS1, indicating that expression of VR-ACO1 and VR-ACS1 genes are under positive and negative feedback control by ethylene, respectively.	Aminooxyacetic Acid	124-127	aconitase 1	Homo sapiens	195-199
11673620-2	2001	Exogenous ethylene markedly increased transcript level of VR-ACO1 and reduced that of VR-ACS1, whereas aminooxyacetic acid (AOA), an inhibitor of ethylene biosynthesis, decreased the level of VR-ACO1 mRNA and increased that of VR-ACS1, indicating that expression of VR-ACO1 and VR-ACS1 genes are under positive and negative feedback control by ethylene, respectively.	Aminooxyacetic Acid	124-127	acyl-CoA synthetase long chain family member 1	Homo sapiens	230-234
11673620-2	2001	Exogenous ethylene markedly increased transcript level of VR-ACO1 and reduced that of VR-ACS1, whereas aminooxyacetic acid (AOA), an inhibitor of ethylene biosynthesis, decreased the level of VR-ACO1 mRNA and increased that of VR-ACS1, indicating that expression of VR-ACO1 and VR-ACS1 genes are under positive and negative feedback control by ethylene, respectively.	Aminooxyacetic Acid	124-127	aconitase 1	Homo sapiens	195-199
11673620-2	2001	Exogenous ethylene markedly increased transcript level of VR-ACO1 and reduced that of VR-ACS1, whereas aminooxyacetic acid (AOA), an inhibitor of ethylene biosynthesis, decreased the level of VR-ACO1 mRNA and increased that of VR-ACS1, indicating that expression of VR-ACO1 and VR-ACS1 genes are under positive and negative feedback control by ethylene, respectively.	Aminooxyacetic Acid	124-127	acyl-CoA synthetase long chain family member 1	Homo sapiens	230-234
11060297-6	2001	The metabolism of [5-(3)H]glucose and the glucose-stimulated insulin secretion from rat insulinoma cells, INS-1, were effectively inhibited by 500 microm or 1 mm propyl gallate and to a lesser extent by 5 mm aminooxyacetate, a potent malate-aspartate shuttle inhibitor.	Aminooxyacetic Acid	208-223	insulin 1	Rattus norvegicus	106-111
11129580-6	2000	2-Aminooxyacetic acid, an inhibitor of phenylalanine ammonia-lyase (PAL), inhibited the accumulation of hydroxyanigorufone in wounded fruit, and the PAL activity increased after wounding and ethylene treatment, respectively.	Aminooxyacetic Acid	0-21	phenylalanine ammonia-lyase	Musa acuminata	39-66
11129580-6	2000	2-Aminooxyacetic acid, an inhibitor of phenylalanine ammonia-lyase (PAL), inhibited the accumulation of hydroxyanigorufone in wounded fruit, and the PAL activity increased after wounding and ethylene treatment, respectively.	Aminooxyacetic Acid	0-21	phenylalanine ammonia-lyase	Musa acuminata	149-152
10510976-4	1999	Regional GABA levels were determined after vehicle injection as well as 30 and 90 min after administration of aminooxyacetic acid (AOAA) at a dose which completely inhibits GABA-T.	Aminooxyacetic Acid	110-129	4-aminobutyrate aminotransferase	Rattus norvegicus	173-179
10636849-11	2000	Inhibition of the malate-aspartate NADH shuttle with aminooxyacetate only had minor effects in control islets but abolished the electrical, [Ca(2+)](i) and secretory responses in mGPDH(-/-) islets.	Aminooxyacetic Acid	53-68	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	179-184
10900239-6	2000	Similarly, coadministration of heroin with aminooxy-acetic acid (1-4 mg/kg) or ethanolamine-O-sulfate (50-100 mg/kg), two reversible GABA transaminase inhibitors, dose dependently reduced heroin reinforcement.	Aminooxyacetic Acid	43-63	4-aminobutyrate aminotransferase	Rattus norvegicus	133-150
10510976-4	1999	Regional GABA levels were determined after vehicle injection as well as 30 and 90 min after administration of aminooxyacetic acid (AOAA) at a dose which completely inhibits GABA-T.	Aminooxyacetic Acid	131-135	4-aminobutyrate aminotransferase	Rattus norvegicus	173-179
10397370-7	1999	Aminooxyacetic acid (10-100 microM), an inhibitor of GABA-transaminase and, to a lesser extent, glutamate decarboxylase, caused an increase in measured uptake in both thalamic and cortical synaptosomes, in both strains.	Aminooxyacetic Acid	0-19	4-aminobutyrate aminotransferase	Rattus norvegicus	53-70
10397370-7	1999	Aminooxyacetic acid (10-100 microM), an inhibitor of GABA-transaminase and, to a lesser extent, glutamate decarboxylase, caused an increase in measured uptake in both thalamic and cortical synaptosomes, in both strains.	Aminooxyacetic Acid	0-19	glutamate-ammonia ligase	Rattus norvegicus	96-119
10080689-6	1999	Additional characterization of ACS6 gene expression indicated that the gene is also induced by wounding, and by treatment with LiCl, NaCl, CuCl2, auxin, cycloheximide (CHX), aminooxyacetic acid (AOA) and ethylene.	Aminooxyacetic Acid	174-193	1-aminocyclopropane-1-carboxylic acid (acc) synthase 6	Arabidopsis thaliana	31-35
10199125-2	1999	When both shuttles were halted in mGPDH-deficient islets treated with aminooxyacetate, an inhibitor of the malate-aspartate shuttle, glucose-induced insulin secretion was almost completely abrogated.	Aminooxyacetic Acid	70-85	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	34-39
10080689-6	1999	Additional characterization of ACS6 gene expression indicated that the gene is also induced by wounding, and by treatment with LiCl, NaCl, CuCl2, auxin, cycloheximide (CHX), aminooxyacetic acid (AOA) and ethylene.	Aminooxyacetic Acid	195-198	1-aminocyclopropane-1-carboxylic acid (acc) synthase 6	Arabidopsis thaliana	31-35
9862904-15	1998	There was a deficit in the duration of potentiation of CA1 population spikes in response to repetitive CA3 stimulation in AOAA-treated rats.	Aminooxyacetic Acid	122-126	carbonic anhydrase 1	Rattus norvegicus	55-58
9862904-15	1998	There was a deficit in the duration of potentiation of CA1 population spikes in response to repetitive CA3 stimulation in AOAA-treated rats.	Aminooxyacetic Acid	122-126	carbonic anhydrase 3	Rattus norvegicus	103-106
9714318-5	1998	Mercaptopyruvate was a more likely metabolic intermediate, as thiocyanate formation from L-cysteine but not thiosulfate was inhibited markedly by aminooxyacetate, a cysteine aminotransferase inhibitor, and propargylglycine, a gamma-cystathionase inhibitor.	Aminooxyacetic Acid	146-161	cystathionine gamma-lyase	Rattus norvegicus	226-245
9178956-4	1997	However, the accumulation of L-aspartate was "enhanced" by inhibitors of L-aspartate metabolism, such as the aspartate aminotransferase inhibitor, aminooxyacetate and L-methionine sulfoximine, an inhibitor of glutamine synthetase, whereas D-aspartate (a non-metabolizable analog of L-aspartate) uptake was not affected.	Aminooxyacetic Acid	147-162	glutamate-ammonia ligase	Homo sapiens	209-229
9657282-4	1998	We have also examined the effect of blocking the renal organic anion transport system with probenecid and of inhibiting the activity of cysteine conjugate beta-lyase with aminooxyacetic acid on the extent of renal injury produced by TFEC.	Aminooxyacetic Acid	171-190	transcription factor EC	Rattus norvegicus	233-237
7968221-6	1994	The inhibition of the GABA aminotransferase by aminooxyacetate decreased lipogenesis from lactate, 3-hydroxybutyrate and glucose.	Aminooxyacetic Acid	47-62	4-aminobutyrate aminotransferase	Rattus norvegicus	22-43
8911659-8	1996	When GABA turnover was estimated after inhibition of GABA-T by aminooxyacetic acid (AOAA), treatment with levetiracetam (given 15 min prior to injection of AOAA) significantly reduced GABA turnover in the striatum.	Aminooxyacetic Acid	63-82	4-aminobutyrate aminotransferase	Rattus norvegicus	53-59
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Aminooxyacetic Acid	177-193	cystathionine beta-synthase	Homo sapiens	65-92
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Aminooxyacetic Acid	177-193	cystathionine beta-synthase	Homo sapiens	94-97
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Aminooxyacetic Acid	177-193	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Aminooxyacetic Acid	177-193	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Aminooxyacetic Acid	177-193	cystathionine beta-synthase	Homo sapiens	144-147
8747487-0	1995	Aminooxy acetic acid: a selective inhibitor of alanine:glyoxylate aminotransferase and its use in the diagnosis of primary hyperoxaluria type I.	Aminooxyacetic Acid	0-20	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	47-82
8747487-5	1995	We therefore developed a simple and direct method for measurement of "true" AGT activity which uses 100 mumol/l aminooxy acetic acid.	Aminooxyacetic Acid	112-132	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	76-79
9152382-4	1997	In particular, the inhibition of GHB dehydrogenase by valproate or ethosuximide and the blockade of GABA-T by aminooxyacetic acid induce the disappearance of the GABA-like effect of GHB at GABAB, but also at GABAA, receptors.	Aminooxyacetic Acid	110-129	4-aminobutyrate aminotransferase	Rattus norvegicus	100-106
8935163-4	1996	ASAT and ALAT were shown to exhibit CSL activity and it was also demonstrated that this activity was inhibited in the presence of the pyridoxal phosphate-dependent enzyme inhibitor amino(oxyacetic acid) confirming the pyridoxal phosphate-dependent mechanism by which C-S lysis is known to take place.	Aminooxyacetic Acid	181-202	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	36-39
7485512-5	1995	The alanine aminotransferase inhibitor aminooxyacetate (AO) inhibited the ODC stimulation by Gln in a dose-dependent manner (half-maximal inhibitory concentration = 0.5 mM).	Aminooxyacetic Acid	39-54	ornithine decarboxylase 1	Sus scrofa	74-77
7485512-5	1995	The alanine aminotransferase inhibitor aminooxyacetate (AO) inhibited the ODC stimulation by Gln in a dose-dependent manner (half-maximal inhibitory concentration = 0.5 mM).	Aminooxyacetic Acid	56-58	ornithine decarboxylase 1	Sus scrofa	74-77
8177378-3	1994	Regional GABA turnover was measured by means of GABA accumulation induced by the GABA-transaminase (GABA-T) inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	118-137	4-aminobutyrate aminotransferase	Rattus norvegicus	81-98
8177378-3	1994	Regional GABA turnover was measured by means of GABA accumulation induced by the GABA-transaminase (GABA-T) inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	118-137	4-aminobutyrate aminotransferase	Rattus norvegicus	100-106
8177378-3	1994	Regional GABA turnover was measured by means of GABA accumulation induced by the GABA-transaminase (GABA-T) inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	139-143	4-aminobutyrate aminotransferase	Rattus norvegicus	81-98
8177378-3	1994	Regional GABA turnover was measured by means of GABA accumulation induced by the GABA-transaminase (GABA-T) inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	139-143	4-aminobutyrate aminotransferase	Rattus norvegicus	100-106
7904899-2	1993	Glutamate-like immunoreactivity (GLI) in horizontal cells could be demonstrated after glutamate decarboxylase was inhibited by aminooxyacetic acid (AOAA) and its degradation to GABA was blocked.	Aminooxyacetic Acid	127-146	glutamate-ammonia ligase	Homo sapiens	86-109
7904899-2	1993	Glutamate-like immunoreactivity (GLI) in horizontal cells could be demonstrated after glutamate decarboxylase was inhibited by aminooxyacetic acid (AOAA) and its degradation to GABA was blocked.	Aminooxyacetic Acid	148-152	glutamate-ammonia ligase	Homo sapiens	86-109
8336820-2	1993	Two typical GABA-transaminase inhibitors, gamma-vinylGABA (GVG) and aminooxyacetic acid (AOAA), increased arterial pressure when injected into the NTS, a response similar to that elicited by direct stimulation of GABA receptors in the NTS.	Aminooxyacetic Acid	89-93	4-aminobutyrate aminotransferase	Rattus norvegicus	12-29
8101728-8	1993	The GABA-uptake inhibitor, nipecotic acid, and the GABA-transaminase inhibitor, aminooxyacetic acid, also increased NAT activity of light-exposed retinas.	Aminooxyacetic Acid	80-99	arylamine N-acetyltransferase, liver isozyme	Gallus gallus	116-119
8336820-2	1993	Two typical GABA-transaminase inhibitors, gamma-vinylGABA (GVG) and aminooxyacetic acid (AOAA), increased arterial pressure when injected into the NTS, a response similar to that elicited by direct stimulation of GABA receptors in the NTS.	Aminooxyacetic Acid	68-87	4-aminobutyrate aminotransferase	Rattus norvegicus	12-29
16653094-7	1992	Degradation of this enzyme protein was moderately inhibited by the administration of aminooxyacetic acid, a competitive inhibitor of ACC synthase with respect to its substrate S-adenosyl-l-methionine, alpha,alpha"-dipyridyl, and phenylmethanesulfonyl fluoride or leupeptin, serine protease inhibitors.	Aminooxyacetic Acid	85-104	serine protease	Solanum lycopersicum	274-289
1447182-8	1992	Inhibiting the covalent binding with a beta-lyase inhibitor, aminooxyacetic acid, blocked the increase in hsp70 mRNA.	Aminooxyacetic Acid	61-80	heat shock protein family A (Hsp70) member 4	Homo sapiens	106-111
1325666-6	1992	Similar effects were observed following the infusion of aminooxyacetic acid (a blocker of GABA-transaminase).	Aminooxyacetic Acid	56-75	4-aminobutyrate aminotransferase	Rattus norvegicus	90-107
1436701-1	1992	The proenkephalin (PE) gene expression within Met-enkephalin (ME) neurons of the guinea pig magnocellular dorsal nucleus (MDN) was measured following activation of GABAergic transmission by aminooxyacetic acid treatment (AOAA).	Aminooxyacetic Acid	190-209	proenkephalin-A	Cavia porcellus	4-17
11607250-7	1992	Evidence that ANR activity is regulated by the glutamine formed by NH4+ assimilation was provided by studies showing that inhibitors of glutamine metabolism (azaserine, albizziin, and aminooxyacetate) inhibited ANR activity in soil treated with NO3- but did not do so in the presence of MSX.	Aminooxyacetic Acid	184-199	NBL1, DAN family BMP antagonist	Homo sapiens	245-248
2246911-5	1990	The aminooxyacetic acid dose and duration were determined by incubating in vitro tissue homogenate and showing that an 8 mmol/L AOA dose for 5 minutes blocked 90% of alanine aminotransferase and aspartate aminotransferase activity.	Aminooxyacetic Acid	4-23	glutamic--pyruvic transaminase	Homo sapiens	166-190
1833221-5	1991	Coadministration of the selective NMDA receptor antagonist D-2-amino-7-phosphonoheptanoic acid (APH) at doses of 45 and 225 nmol caused an almost complete inhibition of seizures produced by 225 nmol AOAA.	Aminooxyacetic Acid	199-203	acylaminoacyl-peptide hydrolase	Rattus norvegicus	96-99
1833221-6	1991	At 225 and 450 nmol, AOAA also caused selective neuronal damage, which was restricted to the CA1 region at the lower dose and also affected the CA3/CA4 area in two of six rats injected with the higher dose.	Aminooxyacetic Acid	21-25	carbonic anhydrase 1	Rattus norvegicus	93-96
1833221-6	1991	At 225 and 450 nmol, AOAA also caused selective neuronal damage, which was restricted to the CA1 region at the lower dose and also affected the CA3/CA4 area in two of six rats injected with the higher dose.	Aminooxyacetic Acid	21-25	carbonic anhydrase 3	Rattus norvegicus	144-147
1833221-6	1991	At 225 and 450 nmol, AOAA also caused selective neuronal damage, which was restricted to the CA1 region at the lower dose and also affected the CA3/CA4 area in two of six rats injected with the higher dose.	Aminooxyacetic Acid	21-25	carbonic anhydrase 4	Rattus norvegicus	148-151
1882327-1	1991	Systemic (s.c.) administration of aminooxyacetic acid (AOAA) in mice triggered clonic convulsions with a CD50 (convulsive dose) of 68 mg/kg (range 54-86).	Aminooxyacetic Acid	34-53	intercellular adhesion molecule 5, telencephalin	Mus musculus	105-109
1882327-1	1991	Systemic (s.c.) administration of aminooxyacetic acid (AOAA) in mice triggered clonic convulsions with a CD50 (convulsive dose) of 68 mg/kg (range 54-86).	Aminooxyacetic Acid	55-59	intercellular adhesion molecule 5, telencephalin	Mus musculus	105-109
2059835-1	1991	The postembedding immunogold procedure was used to detect changes in the levels of gamma-aminobutyric acid (GABA)-like immunoreactivity at the ultrastructural level in the cerebellar cortex of control rats and rats treated with the GABA transaminase inhibitor, amino-oxyacetic acid (AOAA), in order to increase the levels of GABA.	Aminooxyacetic Acid	261-281	4-aminobutyrate aminotransferase	Rattus norvegicus	232-249
2059835-1	1991	The postembedding immunogold procedure was used to detect changes in the levels of gamma-aminobutyric acid (GABA)-like immunoreactivity at the ultrastructural level in the cerebellar cortex of control rats and rats treated with the GABA transaminase inhibitor, amino-oxyacetic acid (AOAA), in order to increase the levels of GABA.	Aminooxyacetic Acid	283-287	4-aminobutyrate aminotransferase	Rattus norvegicus	232-249
1665002-3	1991	These effects of KA were reduced by aminoxyacetic acid (AOAA 25 micrograms/rat, icv), an inhibitor of GABA aminotransferase.	Aminooxyacetic Acid	36-54	4-aminobutyrate aminotransferase	Rattus norvegicus	102-123
1665002-3	1991	These effects of KA were reduced by aminoxyacetic acid (AOAA 25 micrograms/rat, icv), an inhibitor of GABA aminotransferase.	Aminooxyacetic Acid	56-60	4-aminobutyrate aminotransferase	Rattus norvegicus	102-123
34439739-2	2021	To facilitate future clinical translation, we have synthesized a variety of novel CBS-targeting, esterase-cleavable prodrugs based on the structure of the prototypical CBS inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	182-201	cystathionine beta-synthase	Homo sapiens	82-85
2360207-9	1990	Aminooxyacetic acid blocked the effect of DCVC, TFEC, and PCBC on lipoyl dehydrogenase, indicating that metabolism by the mitochondrial fraction is required to produce enzyme inhibition.	Aminooxyacetic Acid	0-19	transcription factor EC	Rattus norvegicus	48-52
2147669-2	1990	Pretreatment with aminooxyacetic acid (AOAA), a GABA transaminase inhibitor, antagonised picrotoxin-induced myoclonus.	Aminooxyacetic Acid	18-37	4-aminobutyrate aminotransferase	Rattus norvegicus	48-65
2147669-2	1990	Pretreatment with aminooxyacetic acid (AOAA), a GABA transaminase inhibitor, antagonised picrotoxin-induced myoclonus.	Aminooxyacetic Acid	39-43	4-aminobutyrate aminotransferase	Rattus norvegicus	48-65
1972258-6	1990	Aminooxyacetic acid an inhibitor of GABA transaminase, induced a decrease in IR-SRIF concentration in the pyriform and entorhinal cortex, whereas ethanolamine-o-sulfate, another GABA-transaminase inhibitor and muscimol, a GABA receptor agonist had no effect on brain IR-SRIF after acute administration.	Aminooxyacetic Acid	0-19	4-aminobutyrate aminotransferase	Rattus norvegicus	36-53
34381810-4	2021	Immunofluorescence staining, Western blot assay and Real-time PCR assays were conducted to determine the activation of Iba-1, the protein levels of iNOS and COX2 and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in vivo, showing that both pre-treatment and post-treatment of aminooxyacetic acid (AOAA) - an MAS inhibitor - profoundly decreased the LPS-induced neuroinflammation in mice.	Aminooxyacetic Acid	278-297	induction of brown adipocytes 1	Mus musculus	119-124
34381810-4	2021	Immunofluorescence staining, Western blot assay and Real-time PCR assays were conducted to determine the activation of Iba-1, the protein levels of iNOS and COX2 and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in vivo, showing that both pre-treatment and post-treatment of aminooxyacetic acid (AOAA) - an MAS inhibitor - profoundly decreased the LPS-induced neuroinflammation in mice.	Aminooxyacetic Acid	278-297	nitric oxide synthase 2, inducible	Mus musculus	148-152
34381810-4	2021	Immunofluorescence staining, Western blot assay and Real-time PCR assays were conducted to determine the activation of Iba-1, the protein levels of iNOS and COX2 and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in vivo, showing that both pre-treatment and post-treatment of aminooxyacetic acid (AOAA) - an MAS inhibitor - profoundly decreased the LPS-induced neuroinflammation in mice.	Aminooxyacetic Acid	278-297	cytochrome c oxidase II, mitochondrial	Mus musculus	157-161
34381810-4	2021	Immunofluorescence staining, Western blot assay and Real-time PCR assays were conducted to determine the activation of Iba-1, the protein levels of iNOS and COX2 and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in vivo, showing that both pre-treatment and post-treatment of aminooxyacetic acid (AOAA) - an MAS inhibitor - profoundly decreased the LPS-induced neuroinflammation in mice.	Aminooxyacetic Acid	278-297	interleukin 1 alpha	Mus musculus	185-193
34381810-4	2021	Immunofluorescence staining, Western blot assay and Real-time PCR assays were conducted to determine the activation of Iba-1, the protein levels of iNOS and COX2 and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in vivo, showing that both pre-treatment and post-treatment of aminooxyacetic acid (AOAA) - an MAS inhibitor - profoundly decreased the LPS-induced neuroinflammation in mice.	Aminooxyacetic Acid	278-297	interleukin 6	Mus musculus	195-199
34381810-4	2021	Immunofluorescence staining, Western blot assay and Real-time PCR assays were conducted to determine the activation of Iba-1, the protein levels of iNOS and COX2 and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in vivo, showing that both pre-treatment and post-treatment of aminooxyacetic acid (AOAA) - an MAS inhibitor - profoundly decreased the LPS-induced neuroinflammation in mice.	Aminooxyacetic Acid	278-297	tumor necrosis factor	Mus musculus	205-214
34381810-4	2021	Immunofluorescence staining, Western blot assay and Real-time PCR assays were conducted to determine the activation of Iba-1, the protein levels of iNOS and COX2 and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in vivo, showing that both pre-treatment and post-treatment of aminooxyacetic acid (AOAA) - an MAS inhibitor - profoundly decreased the LPS-induced neuroinflammation in mice.	Aminooxyacetic Acid	299-303	induction of brown adipocytes 1	Mus musculus	119-124
34381810-4	2021	Immunofluorescence staining, Western blot assay and Real-time PCR assays were conducted to determine the activation of Iba-1, the protein levels of iNOS and COX2 and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in vivo, showing that both pre-treatment and post-treatment of aminooxyacetic acid (AOAA) - an MAS inhibitor - profoundly decreased the LPS-induced neuroinflammation in mice.	Aminooxyacetic Acid	299-303	nitric oxide synthase 2, inducible	Mus musculus	148-152
34381810-4	2021	Immunofluorescence staining, Western blot assay and Real-time PCR assays were conducted to determine the activation of Iba-1, the protein levels of iNOS and COX2 and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in vivo, showing that both pre-treatment and post-treatment of aminooxyacetic acid (AOAA) - an MAS inhibitor - profoundly decreased the LPS-induced neuroinflammation in mice.	Aminooxyacetic Acid	299-303	cytochrome c oxidase II, mitochondrial	Mus musculus	157-161
34381810-4	2021	Immunofluorescence staining, Western blot assay and Real-time PCR assays were conducted to determine the activation of Iba-1, the protein levels of iNOS and COX2 and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in vivo, showing that both pre-treatment and post-treatment of aminooxyacetic acid (AOAA) - an MAS inhibitor - profoundly decreased the LPS-induced neuroinflammation in mice.	Aminooxyacetic Acid	299-303	interleukin 1 alpha	Mus musculus	185-193
34381810-4	2021	Immunofluorescence staining, Western blot assay and Real-time PCR assays were conducted to determine the activation of Iba-1, the protein levels of iNOS and COX2 and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in vivo, showing that both pre-treatment and post-treatment of aminooxyacetic acid (AOAA) - an MAS inhibitor - profoundly decreased the LPS-induced neuroinflammation in mice.	Aminooxyacetic Acid	299-303	interleukin 6	Mus musculus	195-199
34381810-4	2021	Immunofluorescence staining, Western blot assay and Real-time PCR assays were conducted to determine the activation of Iba-1, the protein levels of iNOS and COX2 and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in vivo, showing that both pre-treatment and post-treatment of aminooxyacetic acid (AOAA) - an MAS inhibitor - profoundly decreased the LPS-induced neuroinflammation in mice.	Aminooxyacetic Acid	299-303	tumor necrosis factor	Mus musculus	205-214
34381810-8	2021	Our study has further suggested that AOAA produced inhibition of LPS-induced microglial activation at least partially by decreasing STAT3 phosphorylation.	Aminooxyacetic Acid	37-41	signal transducer and activator of transcription 3	Mus musculus	132-137
1688566-5	1990	Amino acid-stimulated gastrin secretion was unaffected by decarboxylase inhibitors (alpha methyldopa, aminooxyacetic acid, and 4-deoxypyridoxine) but enhanced by bombesin, isobutylmethylxanthine, and dibutyryl cAMP.	Aminooxyacetic Acid	102-121	gastrin	Canis lupus familiaris	22-29
33770141-5	2021	Experiments were repeated in mice after a) treatment with cyclophosphamide; b) bone marrow transplantation (BMT) from a Cse+/+ donor; c) treatment with H2S synthesis inhibitor aminooxyacetic acid (AlphaOmicronAlphaAlpha) or propargylglycine (PAG) and d) H2S donor sodium thiosulfate (STS) or GYY3147.	Aminooxyacetic Acid	176-195	cystathionase (cystathionine gamma-lyase)	Mus musculus	120-123
34902580-5	2022	In addition, cystathionine-gamma-lyase (CSE) inhibitor D,L-propargylglycine (PAG, 10-2 M), cystathionine-beta-synthase inhibitor (CBS) aminooxyacetic acid (AOAA, 10-2 M), and the combination of these inhibitors significantly reduced the relaxant responses induced by l-cysteine and BRL 37344.	Aminooxyacetic Acid	135-154	cystathionine beta-synthase	Mus musculus	91-118
34902580-5	2022	In addition, cystathionine-gamma-lyase (CSE) inhibitor D,L-propargylglycine (PAG, 10-2 M), cystathionine-beta-synthase inhibitor (CBS) aminooxyacetic acid (AOAA, 10-2 M), and the combination of these inhibitors significantly reduced the relaxant responses induced by l-cysteine and BRL 37344.	Aminooxyacetic Acid	156-160	cystathionine beta-synthase	Mus musculus	91-118
34439739-2	2021	To facilitate future clinical translation, we have synthesized a variety of novel CBS-targeting, esterase-cleavable prodrugs based on the structure of the prototypical CBS inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	182-201	cystathionine beta-synthase	Homo sapiens	168-171
34439739-2	2021	To facilitate future clinical translation, we have synthesized a variety of novel CBS-targeting, esterase-cleavable prodrugs based on the structure of the prototypical CBS inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	203-207	cystathionine beta-synthase	Homo sapiens	82-85
34439739-2	2021	To facilitate future clinical translation, we have synthesized a variety of novel CBS-targeting, esterase-cleavable prodrugs based on the structure of the prototypical CBS inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	203-207	cystathionine beta-synthase	Homo sapiens	168-171
35042677-4	2022	Aminooxyacetate, a prototypical pharmacological inhibitor of CBS, increased the ability of the DS brain tissue to generate ATP in vitro and reversed the electrophysiological and neurobehavioral alterations in vivo.	Aminooxyacetic Acid	0-15	cystathionine beta synthase	Rattus norvegicus	61-64
35590269-5	2022	The early senescence phenotype observed in AHL9 overexpressing lines is inhibited by the ethylene biosynthesis inhibitor aminooxyacetic acid suggesting the involvement of ethylene in the AHL9-associated senescence.	Aminooxyacetic Acid	121-140	AT hook motif DNA-binding family protein	Arabidopsis thaliana	43-47
34579557-10	2021	In brain slices of the SON, aminooxyacetate (a CBS blocker) significantly increased the expression of GFAP proteins that were molecularly associated with CBS.	Aminooxyacetic Acid	28-43	glial fibrillary acidic protein	Rattus norvegicus	102-106
2597169-6	1989	Inhibition of renal cysteine-S-conjugate beta-lyase by aminooxyacetic acid alleviated the cytotoxicity of both the cysteine-S-conjugates and the mercapturic acids of the four haloethylenes.	Aminooxyacetic Acid	55-74	kynurenine aminotransferase 1	Rattus norvegicus	20-51
2620967-2	1989	We have studied the antimyoclonic effect of clonazepam and compared it with that of aminooxyacetic acid (AOAA), a GABA transaminase inhibitor, against myoclonus induced by picrotoxin, a GABA receptor antagonist and allylglycine, a drug which inhibits synthesis and release of GABA.	Aminooxyacetic Acid	84-103	4-aminobutyrate aminotransferase	Rattus norvegicus	114-131
2631156-4	1989	Hair follicle GABA-T activity was completely inhibited by preincubation of the samples with either 5 x 10(-8) mol/l aminooxyacetic acid or 5 x 10(-4) mol/l gamma-vinyl GABA.	Aminooxyacetic Acid	116-135	4-aminobutyrate aminotransferase	Homo sapiens	14-20
2564422-0	1989	Aspartate aminotransferase for synthesis of transmitter glutamate in the medulla oblongata: effect of aminooxyacetic acid and 2-oxoglutarate.	Aminooxyacetic Acid	102-121	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	0-26
2472890-14	1989	The addition of 10(-4) M GABA or of the GABA transaminase inhibitor gamma-acetylenic GABA or aminooxyacetic acid inhibited the melatonin content and/or release to the medium in rat pineal organotypic cultures.	Aminooxyacetic Acid	93-112	4-aminobutyrate aminotransferase	Rattus norvegicus	40-57
2924857-4	1989	In control rats injection of the GABA-transaminase inhibitor, amino oxyacetic acid (AOAA), led to a 46% increase in the number of cell somata immunoreactive for GABA.	Aminooxyacetic Acid	62-82	4-aminobutyrate aminotransferase	Rattus norvegicus	33-50
2924857-4	1989	In control rats injection of the GABA-transaminase inhibitor, amino oxyacetic acid (AOAA), led to a 46% increase in the number of cell somata immunoreactive for GABA.	Aminooxyacetic Acid	84-88	4-aminobutyrate aminotransferase	Rattus norvegicus	33-50
2591638-2	1989	The Km for ammonia of carbamyl phosphate synthetase was determined by preincubating isolated liver cells for 30 min in the absence of ammonia and bicarbonate and in the presence of ornithine, chloroquine, which blocks lysosomal proteolysis, and aminoxy acetic acid, which inhibits transaminases.	Aminooxyacetic Acid	245-264	carbamoyl-phosphate synthase 1	Rattus norvegicus	22-51
2906433-6	1988	Aminooxyacetic acid, which increases the endogenous GABA content by inhibiting the GABA-transaminase, increased the tonic component significantly; this increase was antagonized by both bicuculline and picrotoxin.	Aminooxyacetic Acid	0-19	4-aminobutyrate aminotransferase	Mus musculus	83-100
3216949-2	1988	The slices were incubated and superfused in the absence and presence of the GABA aminotransferase (GABA-T) inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	117-136	4-aminobutyrate aminotransferase	Mus musculus	76-97
3216949-2	1988	The slices were incubated and superfused in the absence and presence of the GABA aminotransferase (GABA-T) inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	117-136	4-aminobutyrate aminotransferase	Mus musculus	99-105
3216949-2	1988	The slices were incubated and superfused in the absence and presence of the GABA aminotransferase (GABA-T) inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	138-142	4-aminobutyrate aminotransferase	Mus musculus	99-105
3146234-2	1988	True ODC activity was determined by two methods: (a) addition of the inhibitors alpha-difluoromethylornithine (DFMO), a specific irreversible inhibitor of ODC, or aminooxyacetate (AOA), an inhibitor that blocks the decarboxylation of ornithine by mitochondrial enzymes; and (b) chromatographic analysis of the reaction products.	Aminooxyacetic Acid	163-178	ornithine decarboxylase 1	Rattus norvegicus	5-8
3607459-2	1987	Activation of the GABA system was achieved by raising the brain concentration of GABA with aminooxyacetic acid (AOAA), a GABA-transaminase (GABA-T) inhibitor.	Aminooxyacetic Acid	91-110	4-aminobutyrate aminotransferase	Rattus norvegicus	121-138
3135801-4	1988	Inhibition of GABA transaminase by amino-oxyacetic acid does not change the GABA concentration in the adrenal gland, as compared with the brain, where the GABA concentration rises.	Aminooxyacetic Acid	35-55	4-aminobutyrate aminotransferase	Rattus norvegicus	14-31
20837438-5	1988	The nephrotoxicity of PCBG was blocked by the specific GGT inhibitor, AT-125 (L-alphaS,5S)-alphaamino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid) and by aminooxyacetic aid (AOAA), an inhibitor of beta-lyase.	Aminooxyacetic Acid	174-178	gamma-glutamyltransferase 1	Rattus norvegicus	55-58
3391367-7	1988	Aminooxyacetic acid, a GABA transaminase inhibitor, completely and irreversibly inhibited hepatic GABA catabolism and thereby also inhibited hepatic GABA uptake.	Aminooxyacetic Acid	0-19	4-aminobutyrate aminotransferase	Rattus norvegicus	23-40
3307787-5	1987	Metabolic conversion of 14C-N-Ac-PCBC by kidney and liver cytosol resulted in covalent binding of radioactivity to protein, binding was strongly inhibited by the beta-lyase inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	183-202	EPH receptor B2	Homo sapiens	33-37
3307787-5	1987	Metabolic conversion of 14C-N-Ac-PCBC by kidney and liver cytosol resulted in covalent binding of radioactivity to protein, binding was strongly inhibited by the beta-lyase inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	204-208	EPH receptor B2	Homo sapiens	33-37
3607459-2	1987	Activation of the GABA system was achieved by raising the brain concentration of GABA with aminooxyacetic acid (AOAA), a GABA-transaminase (GABA-T) inhibitor.	Aminooxyacetic Acid	91-110	4-aminobutyrate aminotransferase	Rattus norvegicus	140-146
3607459-2	1987	Activation of the GABA system was achieved by raising the brain concentration of GABA with aminooxyacetic acid (AOAA), a GABA-transaminase (GABA-T) inhibitor.	Aminooxyacetic Acid	112-116	4-aminobutyrate aminotransferase	Rattus norvegicus	121-138
3607459-2	1987	Activation of the GABA system was achieved by raising the brain concentration of GABA with aminooxyacetic acid (AOAA), a GABA-transaminase (GABA-T) inhibitor.	Aminooxyacetic Acid	112-116	4-aminobutyrate aminotransferase	Rattus norvegicus	140-146
3761755-4	1986	Muscimol and AOAA also inhibited decrease in the histamine (HA) level induced by alpha-fluoromethylhistidine (50 mg/kg), a specific inhibitor of histidine decarboxylase.	Aminooxyacetic Acid	13-17	histidine decarboxylase	Mus musculus	145-168
2834253-4	1987	Aminooxy-acetic acid (AOA), an inhibitor of ethylene synthesis, was found to switch development of Dm7 and MF1 cells from macrocyst to sorocarp formation by decreasing ethylene production.	Aminooxyacetic Acid	0-20	flap structure-specific endonuclease 1	Homo sapiens	107-110
2834253-4	1987	Aminooxy-acetic acid (AOA), an inhibitor of ethylene synthesis, was found to switch development of Dm7 and MF1 cells from macrocyst to sorocarp formation by decreasing ethylene production.	Aminooxyacetic Acid	22-25	flap structure-specific endonuclease 1	Homo sapiens	107-110
3304202-3	1987	First, the toxicity of the model conjugate S-(1,2-dichlorovinyl)-L-cysteine (DCVC) is blocked both in vivo and in isolated, renal proximal tubular cells by aminooxyacetic acid, an inhibitor of PLP-dependent enzymes.	Aminooxyacetic Acid	156-175	pyridoxal phosphatase	Homo sapiens	193-196
3725199-2	1986	Blue-diformazan staining of cerebrovascular and parenchymal sites of GABA catabolism in normal brain was almost completely prevented in unfixed frozen brain sections from rats subjected to "in vivo" GABA-T inhibition using aminooxyacetic acid or gabaculine.	Aminooxyacetic Acid	223-242	4-aminobutyrate aminotransferase	Rattus norvegicus	199-205
3933514-9	1985	AOAA and GAG were found to be strong inhibitors of GABA-T whereas the other two compounds were less efficient in the used doses.	Aminooxyacetic Acid	0-4	4-aminobutyrate aminotransferase	Rattus norvegicus	51-57
3711882-2	1986	The intracerebroventricular injection of CADO reduced the GABA turnover rate in the hippocampus, as estimated from the rate of GABA accumulation after inhibition of GABA transaminase (GABA-T) by aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	195-214	4-aminobutyrate aminotransferase	Rattus norvegicus	165-182
3711882-2	1986	The intracerebroventricular injection of CADO reduced the GABA turnover rate in the hippocampus, as estimated from the rate of GABA accumulation after inhibition of GABA transaminase (GABA-T) by aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	195-214	4-aminobutyrate aminotransferase	Rattus norvegicus	184-190
3711882-2	1986	The intracerebroventricular injection of CADO reduced the GABA turnover rate in the hippocampus, as estimated from the rate of GABA accumulation after inhibition of GABA transaminase (GABA-T) by aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	216-220	4-aminobutyrate aminotransferase	Rattus norvegicus	184-190
3562742-6	1986	The other GABA-T inhibitors, amino-oxyacetic acid and gamma-vinyl GABA, produced similar effects to GAG in the PMSG-treated rats.	Aminooxyacetic Acid	29-49	4-aminobutyrate aminotransferase	Rattus norvegicus	10-16
6472485-1	1984	The anticonvulsant effect of inhibitors of GABA-T (R/S-gamma-vinyl-GABA, ethanolamine-O-sulfate, gabaculine, aminooxyacetic acid) was enhanced by 10 mmol/kg glycine in animal seizure models which are based on a functional GABA deficit.	Aminooxyacetic Acid	109-128	4-aminobutyrate aminotransferase	Homo sapiens	43-49
2864920-3	1985	Perfusion of kidneys with aspartate in the presence of amino-oxyacetate resulted in a near-complete inhibition of aspartate metabolism, illustrating the essential role of aspartate aminotransferase in the metabolism of this substrate.	Aminooxyacetic Acid	55-71	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	171-197
3991046-4	1985	An increase of endogenous GABA levels in vivo effected by injection of GABA transaminase blockers (aminooxyacetic acid, 20 mg/kg, twice daily; vinyl GABA, 800 mg/kg) into rats resulted in a similar decrease in rat PRL mRNA levels in the adenohypophysis 3-4 days following commencement of the drug treatment.	Aminooxyacetic Acid	99-118	4-aminobutyrate aminotransferase	Rattus norvegicus	71-88
6747627-5	1984	Pyridoxal phosphate (PLP) activates the enzyme and aminooxyacetic acid inhibits it, the same as these agents activate or inhibit GAD from several nervous tissue sources.	Aminooxyacetic Acid	51-70	glutamate-ammonia ligase	Gallus gallus	129-132
4043235-2	1985	Aminooxyacetic acid (AOAA) and gamma-acetylenic GABA (GAG) added to the incubation medium decreased prolactin release from both male and female rat pituitaries.	Aminooxyacetic Acid	0-19	prolactin	Rattus norvegicus	100-109
4043235-2	1985	Aminooxyacetic acid (AOAA) and gamma-acetylenic GABA (GAG) added to the incubation medium decreased prolactin release from both male and female rat pituitaries.	Aminooxyacetic Acid	21-25	prolactin	Rattus norvegicus	100-109
4043235-3	1985	Additive effects on prolactin release were only observed when male rat pituitaries were incubated with AOAA plus GABA.	Aminooxyacetic Acid	103-107	prolactin	Rattus norvegicus	20-29
6504230-1	1984	Crayfish glutamic acid decarboxylase (GAD), like the homologous enzymes from other species, is inhibited by carbonyl-trapping agents (e.g. aminooxyacetic acid; AOAA) and sulfhydryl reagents (e.g. 5,5"-dithiobis-(2-nitrobenzoic acid); DTNB).	Aminooxyacetic Acid	139-158	glutamate decarboxylase 1	Homo sapiens	9-36
6504230-1	1984	Crayfish glutamic acid decarboxylase (GAD), like the homologous enzymes from other species, is inhibited by carbonyl-trapping agents (e.g. aminooxyacetic acid; AOAA) and sulfhydryl reagents (e.g. 5,5"-dithiobis-(2-nitrobenzoic acid); DTNB).	Aminooxyacetic Acid	139-158	glutamate decarboxylase 1	Homo sapiens	38-41
6504230-1	1984	Crayfish glutamic acid decarboxylase (GAD), like the homologous enzymes from other species, is inhibited by carbonyl-trapping agents (e.g. aminooxyacetic acid; AOAA) and sulfhydryl reagents (e.g. 5,5"-dithiobis-(2-nitrobenzoic acid); DTNB).	Aminooxyacetic Acid	139-158	dystrobrevin beta	Homo sapiens	234-238
6504230-1	1984	Crayfish glutamic acid decarboxylase (GAD), like the homologous enzymes from other species, is inhibited by carbonyl-trapping agents (e.g. aminooxyacetic acid; AOAA) and sulfhydryl reagents (e.g. 5,5"-dithiobis-(2-nitrobenzoic acid); DTNB).	Aminooxyacetic Acid	160-164	glutamate decarboxylase 1	Homo sapiens	9-36
6504230-1	1984	Crayfish glutamic acid decarboxylase (GAD), like the homologous enzymes from other species, is inhibited by carbonyl-trapping agents (e.g. aminooxyacetic acid; AOAA) and sulfhydryl reagents (e.g. 5,5"-dithiobis-(2-nitrobenzoic acid); DTNB).	Aminooxyacetic Acid	160-164	glutamate decarboxylase 1	Homo sapiens	38-41
6504230-1	1984	Crayfish glutamic acid decarboxylase (GAD), like the homologous enzymes from other species, is inhibited by carbonyl-trapping agents (e.g. aminooxyacetic acid; AOAA) and sulfhydryl reagents (e.g. 5,5"-dithiobis-(2-nitrobenzoic acid); DTNB).	Aminooxyacetic Acid	160-164	dystrobrevin beta	Homo sapiens	234-238
6504230-3	1984	The inhibition by AOAA, but not that by DTNB, was prevented by increasing the concentration of the pyridoxal phosphate (PLP) coenzyme.	Aminooxyacetic Acid	18-22	pyridoxal phosphatase	Homo sapiens	120-123
6368574-1	1984	Two transaminase inhibitors, aminooxyacetate and cycloserine, inhibited the initiation of insulin-stimulated DNA synthesis in chick embryo fibroblasts.	Aminooxyacetic Acid	29-44	insulin	Gallus gallus	90-97
6368574-3	1984	Aminooxyacetate also inhibited lactate production in insulin-treated cultures in the absence of added alpha-keto acid.	Aminooxyacetic Acid	0-15	insulin	Gallus gallus	53-60
6700374-3	1984	The specific binding was directly proportional to the activity of the enzyme measured in vitro and was completely inhibited by the GABA-transaminase inhibitors aminooxyacetic acid (100 microM) and 3-mercaptopropionic acid (1.0mM).	Aminooxyacetic Acid	160-179	4-aminobutyrate aminotransferase	Rattus norvegicus	131-148
6140307-1	1983	The effects of inhibiting gamma-aminobutyric acid-transaminase (GABA-T) with aminooxyacetic acid or with gabaculine and inhibiting GABA uptake with nipecotic acid on dopamine (DA) synthesis in the retina of light-exposed rats were studied.	Aminooxyacetic Acid	77-96	4-aminobutyrate aminotransferase	Rattus norvegicus	26-62
6538868-0	1984	Prolactin and milk ejection during the first 20 minutes of suckling in the rat: blockade by Nembutal and by amino oxyacetic acid.	Aminooxyacetic Acid	108-128	prolactin	Rattus norvegicus	0-9
6140307-1	1983	The effects of inhibiting gamma-aminobutyric acid-transaminase (GABA-T) with aminooxyacetic acid or with gabaculine and inhibiting GABA uptake with nipecotic acid on dopamine (DA) synthesis in the retina of light-exposed rats were studied.	Aminooxyacetic Acid	77-96	4-aminobutyrate aminotransferase	Rattus norvegicus	64-70
6619872-2	1983	beta-Methylene-D,L-aspartate (2 mM), aminooxyacetate (0.1 mM), and D,L-vinylglycine (20 mM) all significantly reduced the activity of aspartate aminotransferase and the rate of oxygen consumption of rat cerebral cortex slices respiring on glucose.	Aminooxyacetic Acid	37-52	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	134-160
6668764-6	1983	Aminooxyacetic acid, an inhibitor of GABA transaminase, potentiated the effect of GABA.	Aminooxyacetic Acid	0-19	4-aminobutyrate aminotransferase	Rattus norvegicus	37-54
6652347-8	1983	In contrast, however, treatment with the GABA transaminase inhibitors, amino-oxyacetic acid (25 mg kg-1) or ethanolamine-O-sulphate (250 mg kg-1, 7 days) which elevated cerebral GABA concentrations, enhanced the reduction in cortical 5-HT turnover following diazepam.	Aminooxyacetic Acid	71-91	4-aminobutyrate aminotransferase	Rattus norvegicus	41-58
6889412-2	1983	The aminooxyacetic acid (AOAA) or L-cycloserine-induced accumulation of GABA was decreased, and the activity of glutamate decarboxylase (GAD), the enzyme responsible for GABA synthesis, was increased following ether stress.	Aminooxyacetic Acid	4-23	glutamate-ammonia ligase	Rattus norvegicus	137-140
6420629-3	1983	Inhibition of GABA-transaminase (GABA-T) by aminooxyacetic acid (AOAA) in other compartments of the brain would result in an inhibition of the stimulated GABA-release via feedback on autoreceptors and therefore suppress the DPA-evoked behaviour.	Aminooxyacetic Acid	44-63	4-aminobutyrate aminotransferase	Rattus norvegicus	14-31
6420629-3	1983	Inhibition of GABA-transaminase (GABA-T) by aminooxyacetic acid (AOAA) in other compartments of the brain would result in an inhibition of the stimulated GABA-release via feedback on autoreceptors and therefore suppress the DPA-evoked behaviour.	Aminooxyacetic Acid	44-63	4-aminobutyrate aminotransferase	Rattus norvegicus	33-39
6420629-3	1983	Inhibition of GABA-transaminase (GABA-T) by aminooxyacetic acid (AOAA) in other compartments of the brain would result in an inhibition of the stimulated GABA-release via feedback on autoreceptors and therefore suppress the DPA-evoked behaviour.	Aminooxyacetic Acid	65-69	4-aminobutyrate aminotransferase	Rattus norvegicus	14-31
6420629-3	1983	Inhibition of GABA-transaminase (GABA-T) by aminooxyacetic acid (AOAA) in other compartments of the brain would result in an inhibition of the stimulated GABA-release via feedback on autoreceptors and therefore suppress the DPA-evoked behaviour.	Aminooxyacetic Acid	65-69	4-aminobutyrate aminotransferase	Rattus norvegicus	33-39
6816278-8	1982	Aminooxyacetate, an inhibitor of alanine aminotransferase, completely inhibited this efflux and glandular pyruvate production.	Aminooxyacetic Acid	0-15	glutamic--pyruvic transaminase	Homo sapiens	33-57
7295890-4	1981	3-Mercaptopicolinate and amino-oxyacetate, specific inhibitors of PEP CK and aminotransferase-type enzymes, respectively, decreased 14C-incorporation from L-[U-14C]glutamate into glycogen.	Aminooxyacetic Acid	25-41	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	66-72
7097288-4	1982	The vascular activity was like brain glutamate decarboxylase in that it required pyridoxal phosphate, was completely inhibited by aminooxyacetic acid, and had a similar affinity for glutamate.	Aminooxyacetic Acid	130-149	glutamate-ammonia ligase	Bos taurus	37-60
6805473-1	1982	Mice were treated with different doses of the GABA aminotransferase (GABA-T) inhibitors aminooxyacetic acid, gamma-acetylenic acid, gamma-vinyl GABA and ethanolamine-O-sulphate via the drinking water for periods of 1-12.	Aminooxyacetic Acid	88-107	4-aminobutyrate aminotransferase	Mus musculus	69-75
7325996-0	1981	Re-activation by glutamate or aspartate of amino-oxyacetate-inhibited aspartate aminotransferase in vitro and in isolated hepatocytes.	Aminooxyacetic Acid	43-59	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	70-96
7264654-1	1981	Most studies on gamma-aminobutyric acid (GABA) release from nervous tissue have been conducted using radiolabelled GABA in the presence of aminooxyacetic acid (AOAA) to inhibit GABA: 2-oxoglutarate aminotransferase (GABA-T) to prevent conversion of labelled GABA to labelled catabolites.	Aminooxyacetic Acid	139-158	4-aminobutyrate aminotransferase	Rattus norvegicus	177-214
7264654-1	1981	Most studies on gamma-aminobutyric acid (GABA) release from nervous tissue have been conducted using radiolabelled GABA in the presence of aminooxyacetic acid (AOAA) to inhibit GABA: 2-oxoglutarate aminotransferase (GABA-T) to prevent conversion of labelled GABA to labelled catabolites.	Aminooxyacetic Acid	160-164	4-aminobutyrate aminotransferase	Rattus norvegicus	177-214
7264654-1	1981	Most studies on gamma-aminobutyric acid (GABA) release from nervous tissue have been conducted using radiolabelled GABA in the presence of aminooxyacetic acid (AOAA) to inhibit GABA: 2-oxoglutarate aminotransferase (GABA-T) to prevent conversion of labelled GABA to labelled catabolites.	Aminooxyacetic Acid	160-164	4-aminobutyrate aminotransferase	Rattus norvegicus	216-222
7451494-4	1981	Furthermore, pretreatment of the crude homogenate with aminooxyacetic acid and alpha-methyl-trans-3-dehydroglutamate, two inactivators of glutamate decarboxylase which function by entirely different mechanisms, decreased count incorporation ([alpha-3H]acetylenic gamma-aminobutyric acid) to the same extent as the activity was decreased.	Aminooxyacetic Acid	55-74	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	138-161
7348023-3	1981	Aminooxyacetic acid (12.5 mg/kg) as a GABA-transaminase inhibitor, decreased the rotation elicited by d-amphetamine or apomorphine.	Aminooxyacetic Acid	0-19	4-aminobutyrate aminotransferase	Rattus norvegicus	38-55
6446691-1	1980	Seven patients with Huntington disease were treated with aminooxyacetic acid (AOAA), an inhibitor of gamma-aminobutyric acid aminotransferase (GABA-T), in an effort to alleviate symptoms by increasing brain GABA content.	Aminooxyacetic Acid	57-76	4-aminobutyrate aminotransferase	Homo sapiens	101-141
7309784-2	1981	The most active inhibitor of GABA-transaminase, amino oxyacetic acid (AOAA), increases the GABA content in the brain and appears to increase the tumor rate in 3-MC rats.	Aminooxyacetic Acid	48-68	4-aminobutyrate aminotransferase	Rattus norvegicus	29-46
7309784-2	1981	The most active inhibitor of GABA-transaminase, amino oxyacetic acid (AOAA), increases the GABA content in the brain and appears to increase the tumor rate in 3-MC rats.	Aminooxyacetic Acid	70-74	4-aminobutyrate aminotransferase	Rattus norvegicus	29-46
6446691-1	1980	Seven patients with Huntington disease were treated with aminooxyacetic acid (AOAA), an inhibitor of gamma-aminobutyric acid aminotransferase (GABA-T), in an effort to alleviate symptoms by increasing brain GABA content.	Aminooxyacetic Acid	57-76	4-aminobutyrate aminotransferase	Homo sapiens	143-149
6446691-1	1980	Seven patients with Huntington disease were treated with aminooxyacetic acid (AOAA), an inhibitor of gamma-aminobutyric acid aminotransferase (GABA-T), in an effort to alleviate symptoms by increasing brain GABA content.	Aminooxyacetic Acid	78-82	4-aminobutyrate aminotransferase	Homo sapiens	101-141
6446691-1	1980	Seven patients with Huntington disease were treated with aminooxyacetic acid (AOAA), an inhibitor of gamma-aminobutyric acid aminotransferase (GABA-T), in an effort to alleviate symptoms by increasing brain GABA content.	Aminooxyacetic Acid	78-82	4-aminobutyrate aminotransferase	Homo sapiens	143-149
574337-6	1978	Experiments with GABA-T inhibition by aminooxyacetic acid give direct evidence about the role of the GABA system in cerebral blood circulation.	Aminooxyacetic Acid	38-57	4-aminobutyrate aminotransferase	Homo sapiens	17-23
6108906-6	1980	Hyperemotionality and muricide were both inhibited by the following drugs given i.p., chlorpromazine; haloperidol; diazepam; estazolam; aminooxyacetic acid (GABA transaminase inhibitor); phenoxybenzamine.	Aminooxyacetic Acid	136-155	4-aminobutyrate aminotransferase	Rattus norvegicus	157-174
7387260-2	1980	Only the nonspecific enzyme inhibitor aminooxyacetic acid (IC50 2.7 microM) proved to be as potent as the catalytic inhibitors gabaculine (1.8 microM), gamma-acetylenic GABA (150 microM) and gamma-vinyl GABA (350 microM) with respect to inhibition of GABA-T.	Aminooxyacetic Acid	38-57	4-aminobutyrate aminotransferase	Homo sapiens	251-257
417370-1	1978	In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats.	Aminooxyacetic Acid	129-149	4-aminobutyrate aminotransferase	Rattus norvegicus	112-118
7411249-3	1980	Aminooxyacetic acid (AOAA) and hydrazine administration increased the GABA content and inhibited the GABA degrading enzyme, GABA transaminase in retina.	Aminooxyacetic Acid	0-19	4-aminobutyrate aminotransferase	Rattus norvegicus	124-141
7411249-3	1980	Aminooxyacetic acid (AOAA) and hydrazine administration increased the GABA content and inhibited the GABA degrading enzyme, GABA transaminase in retina.	Aminooxyacetic Acid	21-25	4-aminobutyrate aminotransferase	Rattus norvegicus	124-141
115227-5	1979	Some compounds known to activate the GABA system, including some benzodiazepines and the GABA-transaminase inhibitor amino-oxyacetic acid, also reduced the symptoms, as did the serotonin precursor L-5HTP.	Aminooxyacetic Acid	117-137	4-aminobutyrate aminotransferase	Homo sapiens	89-106
119887-5	1979	Systemic injection of aminooxyacetic acid in a dose producing behavioral depression reduced markedly the TRH-induced hyperactivity.	Aminooxyacetic Acid	22-41	thyrotropin releasing hormone	Rattus norvegicus	105-108
759200-3	1979	This action of GABA was mimicked by the GABA-T antagonists aminooxyacetic acid and ethanolamine-O-sulphate, but not by the GABA analogues muscimol, 3-aminopropanesulphonic acid, gamma-hydroxybutyrate or beta-(p-chlorophenyl)-GABA.	Aminooxyacetic Acid	59-78	4-aminobutyrate aminotransferase	Homo sapiens	40-46
666736-7	1978	Dopa decarboxylase inhibition by amino-oxyacetate was more rapid and more readily reversible, but measurements of rate and equilibrium constants were not obtained for this enzyme.	Aminooxyacetic Acid	33-49	dopa decarboxylase	Homo sapiens	0-18
1088129-1	1976	The drug aminooxyacetic acid, which inhibits GABA-transaminase, destroys the afferent nerve ending in the inner ear of the frog.	Aminooxyacetic Acid	9-28	4-aminobutyrate aminotransferase	Homo sapiens	45-62
904693-4	1977	Aminooxyacetic acid (AOAA), an inhibitor of GABA-transaminase, when given alone in a dose of 25 mg/kg i.p.	Aminooxyacetic Acid	0-19	4-aminobutyrate aminotransferase	Rattus norvegicus	44-61
904693-4	1977	Aminooxyacetic acid (AOAA), an inhibitor of GABA-transaminase, when given alone in a dose of 25 mg/kg i.p.	Aminooxyacetic Acid	21-25	4-aminobutyrate aminotransferase	Rattus norvegicus	44-61
849292-1	1977	Data are provided which indicate that pyruvate and/or acetaldehyde can reverse the inhibition of alanine aminotransferase and aspartate aminotransferase by amino-oxyacetate.	Aminooxyacetic Acid	156-172	glutamic--pyruvic transaminase	Homo sapiens	97-121
870153-4	1977	Secondly, synaptosomal GABA-T is comparatively more susceptible to inhibition by the substrate analogues 2,4-diaminobutyric acid (DABA) and aminooxyacetic acid (AOAA) than is the enzyme from the cytoplasmic mitochondrial fraction.	Aminooxyacetic Acid	140-159	4-aminobutyrate aminotransferase	Rattus norvegicus	23-29
870153-4	1977	Secondly, synaptosomal GABA-T is comparatively more susceptible to inhibition by the substrate analogues 2,4-diaminobutyric acid (DABA) and aminooxyacetic acid (AOAA) than is the enzyme from the cytoplasmic mitochondrial fraction.	Aminooxyacetic Acid	161-165	4-aminobutyrate aminotransferase	Rattus norvegicus	23-29
187962-7	1976	Enhancement of GABAergic transmission by diazepam or aminooxyacetic acid antagonized the rise in cerebellar cyclic GMP content induced by the dopaminergic stimulants, but was without effect on the cyclic GMP content in the medial forebrain.	Aminooxyacetic Acid	53-72	5'-nucleotidase, cytosolic II	Mus musculus	115-118
12477-2	1976	A similar effect was obtained with the inhibitor of GABA transaminase, aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	92-96	4-aminobutyrate aminotransferase	Rattus norvegicus	52-69
8458-3	1976	Aminooxyacetate attacks the Schiff base linkage of the enzyme several times faster (k1 = 3700 M-1 min-1 and k2 = 1000 M-1 min-1) than it attacks the aldehydic carbon of free P-pyridoxal (k = 290 M-1 min-1).	Aminooxyacetic Acid	0-15	CD59 molecule (CD59 blood group)	Homo sapiens	98-103
8458-3	1976	Aminooxyacetate attacks the Schiff base linkage of the enzyme several times faster (k1 = 3700 M-1 min-1 and k2 = 1000 M-1 min-1) than it attacks the aldehydic carbon of free P-pyridoxal (k = 290 M-1 min-1).	Aminooxyacetic Acid	0-15	CD59 molecule (CD59 blood group)	Homo sapiens	122-127
8458-3	1976	Aminooxyacetate attacks the Schiff base linkage of the enzyme several times faster (k1 = 3700 M-1 min-1 and k2 = 1000 M-1 min-1) than it attacks the aldehydic carbon of free P-pyridoxal (k = 290 M-1 min-1).	Aminooxyacetic Acid	0-15	CD59 molecule (CD59 blood group)	Homo sapiens	122-127
962864-5	1976	Subcellular fractionation of rat liver by differential centrifugation, followed by the assay of ornithine decarboxylase in the presence of amino oxyacetate and of marker enzymes for each fraction, demonstrated that ornithine decarboxylase was located in the cytosol.	Aminooxyacetic Acid	139-155	ornithine decarboxylase 1	Rattus norvegicus	215-238
15575-2	1976	Effect of cycloserine and aminooxyacetate on changes in the rate of oxidation of intramitochondrial NAD(P)H induced by the addition of mAAT].	Aminooxyacetic Acid	26-41	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	135-140
1220680-2	1975	Diamine oxidase inhibitors and carboxymethoxylamine (amino-oxyacetate) markedly inhibit the metabolism of [(14)C]putrescine to (14)CO(2), but affect different enzymes.	Aminooxyacetic Acid	53-69	amine oxidase copper containing 1	Homo sapiens	0-15
64142-4	1976	2.--A significant decrease of glutamine synthetase activity is observed only after administration of both aminooxyacetate and ammonium chloride.	Aminooxyacetic Acid	106-121	glutamate-ammonia ligase	Rattus norvegicus	30-50
4730831-12	1973	Efflux of radioactivity from the retina was strikingly reduced in the presence of AOAA at concentrations sufficient to inhibit GABA-T by 100%.9.	Aminooxyacetic Acid	82-86	4-aminobutyrate aminotransferase	Rattus norvegicus	127-133
4305306-0	1968	Mechanism of inhibition of histidine decarboxylase (Clostridium welchii) by 4-bromo-3-hydroxybenzyloxamine and amino-oxyacetic acid.	Aminooxyacetic Acid	111-131	histidine decarboxylase	Homo sapiens	27-50
32860803-3	2020	Our main objective was to investigate whether the aminooxyacetic acid (AOAA) and DL-Propargylglycine (PAG), two specific inhibitors of CBS and CSE, could assist DIM to play a stronger anti-cancer effects in gastric cancer BGC-823 and SGC-7901 cells.	Aminooxyacetic Acid	71-75	cystathionine beta-synthase	Homo sapiens	135-138
33271147-8	2021	During exposure to an effective CBS and CSE inhibitor (aminooxyacetic acid [AOAA]), the amplitude of oscillation and baseline expression of Per2 significantly increased.	Aminooxyacetic Acid	55-74	cystathionine beta-synthase	Mus musculus	32-35
33271147-8	2021	During exposure to an effective CBS and CSE inhibitor (aminooxyacetic acid [AOAA]), the amplitude of oscillation and baseline expression of Per2 significantly increased.	Aminooxyacetic Acid	55-74	cystathionase (cystathionine gamma-lyase)	Mus musculus	40-43
33271147-8	2021	During exposure to an effective CBS and CSE inhibitor (aminooxyacetic acid [AOAA]), the amplitude of oscillation and baseline expression of Per2 significantly increased.	Aminooxyacetic Acid	55-74	period circadian clock 2	Mus musculus	140-144
33271147-8	2021	During exposure to an effective CBS and CSE inhibitor (aminooxyacetic acid [AOAA]), the amplitude of oscillation and baseline expression of Per2 significantly increased.	Aminooxyacetic Acid	76-80	cystathionine beta-synthase	Mus musculus	32-35
33271147-8	2021	During exposure to an effective CBS and CSE inhibitor (aminooxyacetic acid [AOAA]), the amplitude of oscillation and baseline expression of Per2 significantly increased.	Aminooxyacetic Acid	76-80	cystathionase (cystathionine gamma-lyase)	Mus musculus	40-43
33271147-8	2021	During exposure to an effective CBS and CSE inhibitor (aminooxyacetic acid [AOAA]), the amplitude of oscillation and baseline expression of Per2 significantly increased.	Aminooxyacetic Acid	76-80	period circadian clock 2	Mus musculus	140-144
32860803-3	2020	Our main objective was to investigate whether the aminooxyacetic acid (AOAA) and DL-Propargylglycine (PAG), two specific inhibitors of CBS and CSE, could assist DIM to play a stronger anti-cancer effects in gastric cancer BGC-823 and SGC-7901 cells.	Aminooxyacetic Acid	50-69	cystathionine beta-synthase	Homo sapiens	135-138
32860803-3	2020	Our main objective was to investigate whether the aminooxyacetic acid (AOAA) and DL-Propargylglycine (PAG), two specific inhibitors of CBS and CSE, could assist DIM to play a stronger anti-cancer effects in gastric cancer BGC-823 and SGC-7901 cells.	Aminooxyacetic Acid	50-69	cystathionine gamma-lyase	Homo sapiens	143-146
32860803-3	2020	Our main objective was to investigate whether the aminooxyacetic acid (AOAA) and DL-Propargylglycine (PAG), two specific inhibitors of CBS and CSE, could assist DIM to play a stronger anti-cancer effects in gastric cancer BGC-823 and SGC-7901 cells.	Aminooxyacetic Acid	71-75	cystathionine gamma-lyase	Homo sapiens	143-146
32860803-9	2020	Taken together, AOAA or PAG inhibited the expression of endogenous H2S biosynthesis enzymes and effectively enhanced susceptibility of gastric cancer to DIM through activating p38-p53 axis.	Aminooxyacetic Acid	16-20	mitogen-activated protein kinase 14	Homo sapiens	176-179
32860803-9	2020	Taken together, AOAA or PAG inhibited the expression of endogenous H2S biosynthesis enzymes and effectively enhanced susceptibility of gastric cancer to DIM through activating p38-p53 axis.	Aminooxyacetic Acid	16-20	tumor protein p53	Homo sapiens	180-183
32246641-17	2020	The cystathionine-beta-synthase inhibitor, aminooxyacetic acid, significantly reversed the above neuroprotective effects of L-cysteine.	Aminooxyacetic Acid	43-62	cystathionine beta synthase	Rattus norvegicus	4-31
31594422-5	2020	CSE/CBS inhibitors propargylglycine, beta-cyano-L-alanine, and aminooxyacetic acid blocked brain H2S generation and cerebral vasodilation caused by SFN.	Aminooxyacetic Acid	63-82	cystathionine gamma-lyase	Homo sapiens	0-3
32468069-7	2020	The current density of Nav1.7 was significantly increased in the SNI model and administration of AOAA and U0126 both significantly decreased the density.	Aminooxyacetic Acid	97-101	sodium voltage-gated channel alpha subunit 9	Rattus norvegicus	23-29
32468069-5	2020	AOAA inhibited the increase in the expression of CBS, phosphorylated (p)-MEK1/2, p-ERK1/2 and Nav1.7 induced by SNI, and U0126 (a MEK blocker) was able to inhibit the increase in p-MEK1/2, p-ERK1/2 and Nav1.7 expression.	Aminooxyacetic Acid	0-4	cystathionine beta synthase	Rattus norvegicus	49-52
32072910-14	2020	Further studies showed that AOA not only downregulated the production of the pro-inflammatory cytokines including IFN-gammaand IL-17 but also upregulated the expression of anti-inflammatory cytokine such as IL-10, which might be caused by inhibiting the expressions of p-Stat1 and NF-kappaB.	Aminooxyacetic Acid	28-31	interleukin 10	Mus musculus	207-212
32468069-5	2020	AOAA inhibited the increase in the expression of CBS, phosphorylated (p)-MEK1/2, p-ERK1/2 and Nav1.7 induced by SNI, and U0126 (a MEK blocker) was able to inhibit the increase in p-MEK1/2, p-ERK1/2 and Nav1.7 expression.	Aminooxyacetic Acid	0-4	mitogen activated protein kinase kinase 1	Rattus norvegicus	73-79
32468069-5	2020	AOAA inhibited the increase in the expression of CBS, phosphorylated (p)-MEK1/2, p-ERK1/2 and Nav1.7 induced by SNI, and U0126 (a MEK blocker) was able to inhibit the increase in p-MEK1/2, p-ERK1/2 and Nav1.7 expression.	Aminooxyacetic Acid	0-4	mitogen activated protein kinase 3	Rattus norvegicus	83-89
32468069-5	2020	AOAA inhibited the increase in the expression of CBS, phosphorylated (p)-MEK1/2, p-ERK1/2 and Nav1.7 induced by SNI, and U0126 (a MEK blocker) was able to inhibit the increase in p-MEK1/2, p-ERK1/2 and Nav1.7 expression.	Aminooxyacetic Acid	0-4	sodium voltage-gated channel alpha subunit 9	Rattus norvegicus	94-100
32468069-5	2020	AOAA inhibited the increase in the expression of CBS, phosphorylated (p)-MEK1/2, p-ERK1/2 and Nav1.7 induced by SNI, and U0126 (a MEK blocker) was able to inhibit the increase in p-MEK1/2, p-ERK1/2 and Nav1.7 expression.	Aminooxyacetic Acid	0-4	mitogen activated protein kinase kinase 1	Rattus norvegicus	181-187
32468069-5	2020	AOAA inhibited the increase in the expression of CBS, phosphorylated (p)-MEK1/2, p-ERK1/2 and Nav1.7 induced by SNI, and U0126 (a MEK blocker) was able to inhibit the increase in p-MEK1/2, p-ERK1/2 and Nav1.7 expression.	Aminooxyacetic Acid	0-4	mitogen activated protein kinase 3	Rattus norvegicus	191-197
32468069-5	2020	AOAA inhibited the increase in the expression of CBS, phosphorylated (p)-MEK1/2, p-ERK1/2 and Nav1.7 induced by SNI, and U0126 (a MEK blocker) was able to inhibit the increase in p-MEK1/2, p-ERK1/2 and Nav1.7 expression.	Aminooxyacetic Acid	0-4	sodium voltage-gated channel alpha subunit 9	Rattus norvegicus	202-208
32581821-5	2020	This relaxation was strongly inhibited by the Rho-kinase inhibitor Y-27632 (10 muM), by the reducing agent DTT or by the inhibitor of soluble guanylate cyclase (sGC) ODQ (10 muM) alone or in combination with the inhibitors of the endogenous synthesis of H2S beta-cyano-L-alanine (5 mM) and amino-oxyacetate (5 mM).	Aminooxyacetic Acid	290-306	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	134-159
32581821-5	2020	This relaxation was strongly inhibited by the Rho-kinase inhibitor Y-27632 (10 muM), by the reducing agent DTT or by the inhibitor of soluble guanylate cyclase (sGC) ODQ (10 muM) alone or in combination with the inhibitors of the endogenous synthesis of H2S beta-cyano-L-alanine (5 mM) and amino-oxyacetate (5 mM).	Aminooxyacetic Acid	290-306	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	161-164
32365821-5	2020	Among the small-molecule CBS inhibitors, the review highlights the specificity and selectivity problems related to many of the commonly used "CBS inhibitors" (e.g., aminooxyacetic acid) and provides a comprehensive review of their pharmacological actions under physiological conditions and in various disease models.	Aminooxyacetic Acid	165-184	cystathionine beta-synthase	Homo sapiens	25-28
32365821-5	2020	Among the small-molecule CBS inhibitors, the review highlights the specificity and selectivity problems related to many of the commonly used "CBS inhibitors" (e.g., aminooxyacetic acid) and provides a comprehensive review of their pharmacological actions under physiological conditions and in various disease models.	Aminooxyacetic Acid	165-184	cystathionine beta-synthase	Homo sapiens	142-145
31907178-2	2020	Hydroxylamine (HYD) and carboxymethoxylamine (CAR) have been reported as inhibitors of aspartate aminotransferases (AATs), and interferes with the proliferation in Plasmodium falciparum Therefore, AATs are suggested as drug targets against Plasmodium T. gondii genome encodes only one predicted AAT in both T. gondii type I RH and type II PLK strains.	Aminooxyacetic Acid	24-44	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	116-119
31907178-2	2020	Hydroxylamine (HYD) and carboxymethoxylamine (CAR) have been reported as inhibitors of aspartate aminotransferases (AATs), and interferes with the proliferation in Plasmodium falciparum Therefore, AATs are suggested as drug targets against Plasmodium T. gondii genome encodes only one predicted AAT in both T. gondii type I RH and type II PLK strains.	Aminooxyacetic Acid	24-44	polo like kinase 1	Mus musculus	339-342
31930778-10	2020	Additionally, AOAA attenuated NLRP3-Caspase1/IL-1beta activation and decreased the release of IL-6 and TNF-alpha pro-inflammatory cytokines and reciprocally increased IL-10 anti-inflammatory cytokine level in both ischaemic myocardium and M1 macrophages.	Aminooxyacetic Acid	14-18	NLR family, pyrin domain containing 3	Mus musculus	30-35
31930778-10	2020	Additionally, AOAA attenuated NLRP3-Caspase1/IL-1beta activation and decreased the release of IL-6 and TNF-alpha pro-inflammatory cytokines and reciprocally increased IL-10 anti-inflammatory cytokine level in both ischaemic myocardium and M1 macrophages.	Aminooxyacetic Acid	14-18	caspase 1	Mus musculus	36-44
31930778-10	2020	Additionally, AOAA attenuated NLRP3-Caspase1/IL-1beta activation and decreased the release of IL-6 and TNF-alpha pro-inflammatory cytokines and reciprocally increased IL-10 anti-inflammatory cytokine level in both ischaemic myocardium and M1 macrophages.	Aminooxyacetic Acid	14-18	interleukin 1 beta	Mus musculus	45-53
31930778-10	2020	Additionally, AOAA attenuated NLRP3-Caspase1/IL-1beta activation and decreased the release of IL-6 and TNF-alpha pro-inflammatory cytokines and reciprocally increased IL-10 anti-inflammatory cytokine level in both ischaemic myocardium and M1 macrophages.	Aminooxyacetic Acid	14-18	interleukin 6	Mus musculus	94-98
31930778-10	2020	Additionally, AOAA attenuated NLRP3-Caspase1/IL-1beta activation and decreased the release of IL-6 and TNF-alpha pro-inflammatory cytokines and reciprocally increased IL-10 anti-inflammatory cytokine level in both ischaemic myocardium and M1 macrophages.	Aminooxyacetic Acid	14-18	tumor necrosis factor	Mus musculus	103-112
31930778-10	2020	Additionally, AOAA attenuated NLRP3-Caspase1/IL-1beta activation and decreased the release of IL-6 and TNF-alpha pro-inflammatory cytokines and reciprocally increased IL-10 anti-inflammatory cytokine level in both ischaemic myocardium and M1 macrophages.	Aminooxyacetic Acid	14-18	interleukin 10	Mus musculus	167-172
31930778-11	2020	In conclusion, short-term AOAA treatment significantly improves cardiac function in mice with MI by balancing macrophage polarization through modulating macrophage metabolism and inhibiting NLRP3-Caspase1/IL-1beta pathway.	Aminooxyacetic Acid	26-30	NLR family, pyrin domain containing 3	Mus musculus	190-195
31930778-11	2020	In conclusion, short-term AOAA treatment significantly improves cardiac function in mice with MI by balancing macrophage polarization through modulating macrophage metabolism and inhibiting NLRP3-Caspase1/IL-1beta pathway.	Aminooxyacetic Acid	26-30	caspase 1	Mus musculus	196-204
31930778-11	2020	In conclusion, short-term AOAA treatment significantly improves cardiac function in mice with MI by balancing macrophage polarization through modulating macrophage metabolism and inhibiting NLRP3-Caspase1/IL-1beta pathway.	Aminooxyacetic Acid	26-30	interleukin 1 beta	Mus musculus	205-213
32194794-4	2020	However, the effect of aminooxyacetic acid (AOAA), which has been widely used as an inhibitor of CBS dependent synthesis of H2S, on the chemotherapeutic effect of oxaliplatin (OXA) and the underlying mechanisms remain to be illustrated.	Aminooxyacetic Acid	23-42	cystathionine beta-synthase	Homo sapiens	97-100
32194794-4	2020	However, the effect of aminooxyacetic acid (AOAA), which has been widely used as an inhibitor of CBS dependent synthesis of H2S, on the chemotherapeutic effect of oxaliplatin (OXA) and the underlying mechanisms remain to be illustrated.	Aminooxyacetic Acid	44-48	cystathionine beta-synthase	Homo sapiens	97-100
32072910-14	2020	Further studies showed that AOA not only downregulated the production of the pro-inflammatory cytokines including IFN-gammaand IL-17 but also upregulated the expression of anti-inflammatory cytokine such as IL-10, which might be caused by inhibiting the expressions of p-Stat1 and NF-kappaB.	Aminooxyacetic Acid	28-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	281-290
31817360-7	2019	Inhibition of the malate-aspartate shuttle with aminooxyacetic acid significantly impacted upon cell viability with an IC50 of 11.5 muM in resistant GLUL KO A549 cells compared to 28 muM in control A549 cells, linking resistance to the malate-aspartate shuttle.	Aminooxyacetic Acid	48-67	glutamate-ammonia ligase	Homo sapiens	149-153
31647966-9	2020	A Got1 inhibitor, (aminooxy)acetic acid, ameliorated asthma by shifting differentiation of Th17 cells to Treg cells.	Aminooxyacetic Acid	18-39	glutamic-oxaloacetic transaminase 1	Homo sapiens	2-6
31912705-7	2019	Compared with the control group, the learning and memory abilities of rats with chronic alcoholism were significantly impaired, mitochondria contained vacuoles, hydrogen sulfide increased, but catalase activity and F-actin content were significantly decreased, After treatment with aminooxyacetic acid, mitochondrial morphology improved, hydrogen sulfide content was decreased, while catalase activity and F-actin expression of in hippocampus were increased.	Aminooxyacetic Acid	282-301	catalase	Rattus norvegicus	193-201
31912705-7	2019	Compared with the control group, the learning and memory abilities of rats with chronic alcoholism were significantly impaired, mitochondria contained vacuoles, hydrogen sulfide increased, but catalase activity and F-actin content were significantly decreased, After treatment with aminooxyacetic acid, mitochondrial morphology improved, hydrogen sulfide content was decreased, while catalase activity and F-actin expression of in hippocampus were increased.	Aminooxyacetic Acid	282-301	catalase	Rattus norvegicus	384-392
31912705-8	2019	This indicates that aminooxyacetic acid may improve learning and memory in rats with chronic alcoholism, and the mechanism is related to decreased hydrogen sulfide content and an increase of both catalase activity and F-actin level in the hippocampus, thereby reducing the damage of alcohol to mitochondria and neurons.	Aminooxyacetic Acid	20-39	catalase	Rattus norvegicus	196-204
32865918-5	2020	CCK-8 experiment was used to investigate the influence of the CBS inhibitor amino oxyacetic acid and the CSE inhibitor propargylglycine on the proliferation of U266 cells.	Aminooxyacetic Acid	76-96	cystathionine beta-synthase	Homo sapiens	62-65
32865918-11	2020	AOAA treatment also led to a significant decrease in Bcl-2 expression and dramatic increase in Caspase-3 expression, though NaHS reversed these effects.	Aminooxyacetic Acid	0-4	BCL2 apoptosis regulator	Homo sapiens	53-58
32865918-11	2020	AOAA treatment also led to a significant decrease in Bcl-2 expression and dramatic increase in Caspase-3 expression, though NaHS reversed these effects.	Aminooxyacetic Acid	0-4	caspase 3	Homo sapiens	95-104
31349040-9	2019	Inhibition of H2S-synthesizing enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), by pretreating cells with propargylglycine (PAG) and oxyaminoacetic acid (AOAA) revealed that H2S production was partially dependent on a CSE/CBS-catalyzed beta-elimination reaction with CySSPe that likely produced 1-propenyl persulfide (RSSH).	Aminooxyacetic Acid	185-189	cystathionase (cystathionine gamma-lyase)	Mus musculus	40-65
31349040-9	2019	Inhibition of H2S-synthesizing enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), by pretreating cells with propargylglycine (PAG) and oxyaminoacetic acid (AOAA) revealed that H2S production was partially dependent on a CSE/CBS-catalyzed beta-elimination reaction with CySSPe that likely produced 1-propenyl persulfide (RSSH).	Aminooxyacetic Acid	185-189	cystathionase (cystathionine gamma-lyase)	Mus musculus	67-70
31349040-9	2019	Inhibition of H2S-synthesizing enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), by pretreating cells with propargylglycine (PAG) and oxyaminoacetic acid (AOAA) revealed that H2S production was partially dependent on a CSE/CBS-catalyzed beta-elimination reaction with CySSPe that likely produced 1-propenyl persulfide (RSSH).	Aminooxyacetic Acid	185-189	cystathionine beta-synthase	Mus musculus	76-103
31481613-6	2019	In DS cells, pharmacological inhibition of CBS activity with aminooxyacetate or siRNA-mediated silencing of CBS normalized cellular H2S levels, restored Complex IV activity, improved mitochondrial electron transport and ATP synthesis, and restored cell proliferation.	Aminooxyacetic Acid	61-76	cystathionine beta-synthase	Homo sapiens	43-46
31440142-8	2019	However, H2S could not restore brain CBS expression and H2S content, reduce brain edema, and improve motor performance and memory function after ICH through modulating autophagy and apoptosis when pretreated with the CBS inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	231-250	cystathionine beta-synthase	Mus musculus	217-220
29661856-5	2018	Notably, we find that the transaminase inhibitor aminooxyacetate (AOA) represses cell growth in a TAZ/YAP-dependent manner, identifying transamination as a potential vulnerable metabolic requirement for TAZ/YAP-driven breast cancer.	Aminooxyacetic Acid	49-64	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	98-101
30831241-3	2019	Here we investigated the central effects of aminooxyacetate (AOA; inhibitor of the H2S-synthesizing enzyme cystathionine beta-synthase, CBS) on cardiovascular, respiratory and thermoregulatory responses to hypercapnia in spontaneously hypertensive rats (SHR).	Aminooxyacetic Acid	44-59	cystathionine beta synthase	Rattus norvegicus	107-134
30831241-3	2019	Here we investigated the central effects of aminooxyacetate (AOA; inhibitor of the H2S-synthesizing enzyme cystathionine beta-synthase, CBS) on cardiovascular, respiratory and thermoregulatory responses to hypercapnia in spontaneously hypertensive rats (SHR).	Aminooxyacetic Acid	44-59	cystathionine beta synthase	Rattus norvegicus	136-139
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	Aminooxyacetic Acid	169-185	cystathionase (cystathionine gamma-lyase)	Mus musculus	19-44
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	Aminooxyacetic Acid	169-185	cystathionine beta-synthase	Mus musculus	55-82
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	Aminooxyacetic Acid	169-185	cystathionine beta-synthase	Mus musculus	84-87
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	Aminooxyacetic Acid	187-191	cystathionase (cystathionine gamma-lyase)	Mus musculus	19-44
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	Aminooxyacetic Acid	187-191	cystathionine beta-synthase	Mus musculus	55-82
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	Aminooxyacetic Acid	187-191	cystathionine beta-synthase	Mus musculus	84-87
30036087-5	2019	Mice treated with both PPG and AOAA developed a urine concentration defect in response to dehydration that was accompanied by reduced AQP-2 protein expression.	Aminooxyacetic Acid	31-35	aquaporin 2	Mus musculus	134-139
30127117-17	2018	These findings indicate that aminooxyacetic acid can improve learning and memory in a chronic alcoholism rat model, which may be associated with reduction of hippocampal H2S level and mitochondrial ATPase activity, and up-regulation of myelin basic protein levels in the hippocampus.	Aminooxyacetic Acid	29-48	myelin basic protein	Rattus norvegicus	236-256
29357418-10	2018	Pretreatment with AOAA or NaHS inhibited or promoted PAR4-induced mechanical hyperalgesia, respectively; however, PAG only partially inhibited PAR4-induced bladder pain.	Aminooxyacetic Acid	18-22	F2R like thrombin or trypsin receptor 3	Homo sapiens	53-57
31137614-5	2019	Amino-oxyacetic acid (AOA)-a systemic dual inhibitor of cystathionine-beta-synthase and cystathionine-gamma lyase (two key enzymes in the production of H2S)-was administered to fALS mice.	Aminooxyacetic Acid	0-20	cystathionine beta-synthase	Mus musculus	56-83
31137614-5	2019	Amino-oxyacetic acid (AOA)-a systemic dual inhibitor of cystathionine-beta-synthase and cystathionine-gamma lyase (two key enzymes in the production of H2S)-was administered to fALS mice.	Aminooxyacetic Acid	0-20	cystathionase (cystathionine gamma-lyase)	Mus musculus	88-113
31137614-5	2019	Amino-oxyacetic acid (AOA)-a systemic dual inhibitor of cystathionine-beta-synthase and cystathionine-gamma lyase (two key enzymes in the production of H2S)-was administered to fALS mice.	Aminooxyacetic Acid	22-25	cystathionine beta-synthase	Mus musculus	56-83
31137614-5	2019	Amino-oxyacetic acid (AOA)-a systemic dual inhibitor of cystathionine-beta-synthase and cystathionine-gamma lyase (two key enzymes in the production of H2S)-was administered to fALS mice.	Aminooxyacetic Acid	22-25	cystathionase (cystathionine gamma-lyase)	Mus musculus	88-113
29790697-5	2018	OBJECTIVES: The aim of this study was to compare the influence of HIF-1alpha and c-MYC inhibitors (KG-548 and 10058-F4, respectively) and potential SIRT6 inducers - resveratrol and its synthetic derivative DMU-212 with the effect of glycolysis and glutaminolysis inhibitors (2-deoxyglucose and aminooxyacetic acid, respectively) on the metabolism and expression of metabolic enzymes in FaDu hypopharyngeal carcinoma cells.	Aminooxyacetic Acid	294-313	sirtuin 6	Homo sapiens	148-153
29661856-5	2018	Notably, we find that the transaminase inhibitor aminooxyacetate (AOA) represses cell growth in a TAZ/YAP-dependent manner, identifying transamination as a potential vulnerable metabolic requirement for TAZ/YAP-driven breast cancer.	Aminooxyacetic Acid	49-64	Yes1 associated transcriptional regulator	Homo sapiens	102-105
29661856-5	2018	Notably, we find that the transaminase inhibitor aminooxyacetate (AOA) represses cell growth in a TAZ/YAP-dependent manner, identifying transamination as a potential vulnerable metabolic requirement for TAZ/YAP-driven breast cancer.	Aminooxyacetic Acid	49-64	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	203-206
29661856-5	2018	Notably, we find that the transaminase inhibitor aminooxyacetate (AOA) represses cell growth in a TAZ/YAP-dependent manner, identifying transamination as a potential vulnerable metabolic requirement for TAZ/YAP-driven breast cancer.	Aminooxyacetic Acid	49-64	Yes1 associated transcriptional regulator	Homo sapiens	207-210
29661856-5	2018	Notably, we find that the transaminase inhibitor aminooxyacetate (AOA) represses cell growth in a TAZ/YAP-dependent manner, identifying transamination as a potential vulnerable metabolic requirement for TAZ/YAP-driven breast cancer.	Aminooxyacetic Acid	66-69	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	98-101
29661856-5	2018	Notably, we find that the transaminase inhibitor aminooxyacetate (AOA) represses cell growth in a TAZ/YAP-dependent manner, identifying transamination as a potential vulnerable metabolic requirement for TAZ/YAP-driven breast cancer.	Aminooxyacetic Acid	66-69	Yes1 associated transcriptional regulator	Homo sapiens	102-105
29661856-5	2018	Notably, we find that the transaminase inhibitor aminooxyacetate (AOA) represses cell growth in a TAZ/YAP-dependent manner, identifying transamination as a potential vulnerable metabolic requirement for TAZ/YAP-driven breast cancer.	Aminooxyacetic Acid	66-69	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	203-206
29661856-5	2018	Notably, we find that the transaminase inhibitor aminooxyacetate (AOA) represses cell growth in a TAZ/YAP-dependent manner, identifying transamination as a potential vulnerable metabolic requirement for TAZ/YAP-driven breast cancer.	Aminooxyacetic Acid	66-69	Yes1 associated transcriptional regulator	Homo sapiens	207-210
29298893-8	2018	By contrast, incubation of cells with aminooxyacetic acid, an inhibitor of CBS and cystathionine gamma-lyase, eliminated the increase of H2S production after the cells were exposed to DTT.	Aminooxyacetic Acid	38-57	cystathionine beta-synthase	Homo sapiens	75-78
29061341-9	2018	5-FU-resistant cells exhibited decreased sensitivity to the CBS inhibitor aminooxyacetate (AOAA) in terms of suppression of cell viability, inhibition of cell proliferation and inhibition of oxidative phosphorylation.	Aminooxyacetic Acid	74-89	cystathionine beta-synthase	Homo sapiens	60-63
29061341-9	2018	5-FU-resistant cells exhibited decreased sensitivity to the CBS inhibitor aminooxyacetate (AOAA) in terms of suppression of cell viability, inhibition of cell proliferation and inhibition of oxidative phosphorylation.	Aminooxyacetic Acid	91-95	cystathionine beta-synthase	Homo sapiens	60-63
29353375-4	2018	A dual inhibitor of the biosynthetic enzymes for H2S, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), amino-oxyacetic acid (AOA; 3 mM) reversed the inhibitory responses caused by GYY 4137, L-cysteine and N-acetylcysteine on K+-evoked [3H]D-aspartate release.	Aminooxyacetic Acid	125-145	cystathionine gamma-lyase	Bos taurus	92-117
29353375-4	2018	A dual inhibitor of the biosynthetic enzymes for H2S, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), amino-oxyacetic acid (AOA; 3 mM) reversed the inhibitory responses caused by GYY 4137, L-cysteine and N-acetylcysteine on K+-evoked [3H]D-aspartate release.	Aminooxyacetic Acid	147-150	cystathionine gamma-lyase	Bos taurus	92-117
29298893-8	2018	By contrast, incubation of cells with aminooxyacetic acid, an inhibitor of CBS and cystathionine gamma-lyase, eliminated the increase of H2S production after the cells were exposed to DTT.	Aminooxyacetic Acid	38-57	cystathionine gamma-lyase	Homo sapiens	83-108
28552745-6	2017	The CBS inhibitor amino-oxyacetate (AOAA) reduced both phases of the hypoxic response.	Aminooxyacetic Acid	18-34	cystathionine beta-synthase	Homo sapiens	4-7
29712513-8	2018	Intraperitoneal injection of aminooxyacetic acid, an inhibitor of cystathionine-beta-synthase, attenuated prenatal maternal stress-induced visceral hypersensitivity in a dose-dependent manner.	Aminooxyacetic Acid	29-48	cystathionine beta synthase	Rattus norvegicus	66-93
29712513-9	2018	A consecutive seven-day administration of aminooxyacetic acid reversed the hyperexcitability of colon-specific dorsal root ganglion neurons and markedly reduced Nav1.7 expression.	Aminooxyacetic Acid	42-61	sodium voltage-gated channel alpha subunit 9	Rattus norvegicus	161-167
29207994-5	2017	Significant rightward shift of dose-response curve of L-cysteine was observed with significant decrease in maxima in the presence of amino-oxyacetic acid (AOAA; 100 muM) and d, l-propargylglycine (PAG; 100 muM), the specific blockers of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), respectively.	Aminooxyacetic Acid	155-159	cystathionine beta-synthase-like protein	Bubalus bubalis	237-264
29207994-5	2017	Significant rightward shift of dose-response curve of L-cysteine was observed with significant decrease in maxima in the presence of amino-oxyacetic acid (AOAA; 100 muM) and d, l-propargylglycine (PAG; 100 muM), the specific blockers of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), respectively.	Aminooxyacetic Acid	155-159	cystathionine gamma-lyase	Bubalus bubalis	275-300
29207994-5	2017	Significant rightward shift of dose-response curve of L-cysteine was observed with significant decrease in maxima in the presence of amino-oxyacetic acid (AOAA; 100 muM) and d, l-propargylglycine (PAG; 100 muM), the specific blockers of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), respectively.	Aminooxyacetic Acid	155-159	cystathionine gamma-lyase	Bubalus bubalis	302-305
28978633-11	2017	Moreover, some of these compounds (e.g., cell-permeable prodrugs of the CBS inhibitor aminooxyacetate, or benserazide, a potentially repurposable CBS inhibitor) may serve as starting points for future clinical translation.	Aminooxyacetic Acid	86-101	cystathionine beta-synthase	Homo sapiens	72-75
28783731-3	2017	Here, through the discovery and mechanistic characterization of a small molecule, (aminooxy)acetic acid, that reprograms the differentiation of T helper 17 (TH17) cells towards induced regulatory T (iTreg) cells, we show that increased transamination, mainly catalysed by GOT1, leads to increased levels of 2-hydroxyglutarate in differentiating TH17 cells.	Aminooxyacetic Acid	82-103	glutamic-oxaloacetic transaminase 1, soluble	Mus musculus	272-276
28783731-7	2017	Selective inhibition of GOT1 with (aminooxy)acetic acid ameliorated experimental autoimmune encephalomyelitis in a therapeutic mouse model by regulating the balance between TH17 and iTreg cells.	Aminooxyacetic Acid	34-55	glutamic-oxaloacetic transaminase 1, soluble	Mus musculus	24-28
28847570-5	2017	Furthermore, acetylcholine-induced relaxations were attenuated by cystathionine-gamma-lyase (CSE) inhibitor d,l-propargylglycine (PAG, 10-2 M) and cystathionine-beta-synthase inhibitor (CBS) aminooxyacetic acid (AOAA, 10-3 M).	Aminooxyacetic Acid	191-210	cystathionase (cystathionine gamma-lyase)	Mus musculus	93-96
28847570-5	2017	Furthermore, acetylcholine-induced relaxations were attenuated by cystathionine-gamma-lyase (CSE) inhibitor d,l-propargylglycine (PAG, 10-2 M) and cystathionine-beta-synthase inhibitor (CBS) aminooxyacetic acid (AOAA, 10-3 M).	Aminooxyacetic Acid	212-216	cystathionase (cystathionine gamma-lyase)	Mus musculus	93-96
28300620-5	2017	GABA eliminated SLP, and this was rescued by the GABA-T inhibitors vigabatrin and aminooxyacetic acid.	Aminooxyacetic Acid	82-101	4-aminobutyrate aminotransferase	Mus musculus	49-55
28552745-6	2017	The CBS inhibitor amino-oxyacetate (AOAA) reduced both phases of the hypoxic response.	Aminooxyacetic Acid	36-40	cystathionine beta-synthase	Homo sapiens	4-7
28383821-12	2017	Aminooxyacetic acid (AOAA), a cystathionine beta-synthase inhibitor, exerted inhibitory effects on fundus smooth muscle tension; these effects were also suppressed by l-NAME.	Aminooxyacetic Acid	0-19	cystathionine beta-synthase	Homo sapiens	30-57
28383821-12	2017	Aminooxyacetic acid (AOAA), a cystathionine beta-synthase inhibitor, exerted inhibitory effects on fundus smooth muscle tension; these effects were also suppressed by l-NAME.	Aminooxyacetic Acid	21-25	cystathionine beta-synthase	Homo sapiens	30-57
28512446-9	2017	Importantly, all the beneficial effects of l-cysteine in SAH were abrogated by amino-oxyacetic acid, a CBS inhibitor.	Aminooxyacetic Acid	79-99	cystathionine beta synthase	Rattus norvegicus	103-106
28713283-6	2017	Inhibition of endogenous H2S production by bath application of the CBS inhibitor, aminooxyacetic acid (AOAA, 0.1-1.0 mM) to rhythmic brainstem spinal cord (BSSC) and medullary slice preparations from newborn rats, or local application of AOAA into the preBotC (slices only) caused a dose-dependent decrease in burst frequency.	Aminooxyacetic Acid	82-101	cystathionine beta synthase	Rattus norvegicus	67-70
28713283-6	2017	Inhibition of endogenous H2S production by bath application of the CBS inhibitor, aminooxyacetic acid (AOAA, 0.1-1.0 mM) to rhythmic brainstem spinal cord (BSSC) and medullary slice preparations from newborn rats, or local application of AOAA into the preBotC (slices only) caused a dose-dependent decrease in burst frequency.	Aminooxyacetic Acid	103-107	cystathionine beta synthase	Rattus norvegicus	67-70
28464016-8	2017	Furthermore, MUC1 expression altered the sensitivity of cells to transaminase inhibitor aminooxyacetate (AOA), potentially by altering glutamine metabolism.	Aminooxyacetic Acid	88-103	mucin 1, cell surface associated	Homo sapiens	13-17
27905525-5	2016	Here we showed that inhibition of CBS activity by O-(Carboxymethyl) hydroxylamine hemihydrochloride (AOAA) significantly attenuated pain hypersensitivity in LDH rats.	Aminooxyacetic Acid	101-105	cystathionine beta synthase	Rattus norvegicus	34-37
28464016-8	2017	Furthermore, MUC1 expression altered the sensitivity of cells to transaminase inhibitor aminooxyacetate (AOA), potentially by altering glutamine metabolism.	Aminooxyacetic Acid	105-108	mucin 1, cell surface associated	Homo sapiens	13-17
28097769-0	2017	High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate.	Aminooxyacetic Acid	117-132	kynurenine aminotransferase 1	Homo sapiens	44-73
28245547-8	2017	This necessitates the use of GDH under these conditions, shown by insensitivity of the oxidation to the transamination inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	150-154	glutamate dehydrogenase 1	Homo sapiens	29-32
27521834-6	2016	Hexachlorophene (IC50: ~60muM), tannic acid (IC50: ~40muM) and benserazide (IC50: ~30muM) were less potent CBS inhibitors than the two reference compounds AOAA (IC50: ~3muM) and NSC67078 (IC50: ~1muM), while aurintricarboxylic acid (IC50: ~3muM) was equipotent with AOAA.	Aminooxyacetic Acid	155-159	cystathionine beta-synthase	Homo sapiens	107-110
27521839-9	2016	l-cysteine, the substrate for the endogenous H2S production, caused a concentration-dependent relaxation that was reduced by CBS/CSE inhibitor aminooxyacetic acid (AOAA) in MCC strips.	Aminooxyacetic Acid	143-162	cystathionase (cystathionine gamma-lyase)	Mus musculus	129-132
27639598-0	2016	Both the H2S biosynthesis inhibitor aminooxyacetic acid and the mitochondrially targeted H2S donor AP39 exert protective effects in a mouse model of burn injury.	Aminooxyacetic Acid	36-55	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	9-12
27521839-9	2016	l-cysteine, the substrate for the endogenous H2S production, caused a concentration-dependent relaxation that was reduced by CBS/CSE inhibitor aminooxyacetic acid (AOAA) in MCC strips.	Aminooxyacetic Acid	164-168	cystathionase (cystathionine gamma-lyase)	Mus musculus	129-132
27440715-9	2016	Pretreatment with the cystathionine-gamma-lyase inhibitor d/l-propargylglycine (PAG) decreased hypoxic inhibition of sodium transport by H441 monolayers, whereas inhibition of cystathionine-beta-synthase (with aminooxy-acetic acid; AOAA) or 3-mercaptopyruvate sulfurtransferase (with aspartate) had no effect.	Aminooxyacetic Acid	210-230	cystathionine gamma-lyase	Homo sapiens	22-47
27568336-10	2016	Structural analysis showed that the novel mutation, p.Pro28Ser mutation, affects near the dimerization interface of AGT and positioned on binding site instead of the inhibitor, amino-oxyacetic acid (AOA).	Aminooxyacetic Acid	177-197	angiotensinogen	Homo sapiens	116-119
27568336-10	2016	Structural analysis showed that the novel mutation, p.Pro28Ser mutation, affects near the dimerization interface of AGT and positioned on binding site instead of the inhibitor, amino-oxyacetic acid (AOA).	Aminooxyacetic Acid	199-202	angiotensinogen	Homo sapiens	116-119
27440715-9	2016	Pretreatment with the cystathionine-gamma-lyase inhibitor d/l-propargylglycine (PAG) decreased hypoxic inhibition of sodium transport by H441 monolayers, whereas inhibition of cystathionine-beta-synthase (with aminooxy-acetic acid; AOAA) or 3-mercaptopyruvate sulfurtransferase (with aspartate) had no effect.	Aminooxyacetic Acid	232-236	cystathionine gamma-lyase	Homo sapiens	22-47
27062388-10	2016	The reaction catalysed by GABA-T is inhibited by vigabatrin, whereas both GABA-T and AGXT2 activity is inhibited by aminooxyacetic acid (AOA).	Aminooxyacetic Acid	116-135	4-aminobutyrate aminotransferase	Homo sapiens	74-80
27488030-7	2016	Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS.	Aminooxyacetic Acid	194-213	interleukin 6	Homo sapiens	70-83
27488030-7	2016	Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS.	Aminooxyacetic Acid	194-213	interleukin 6	Homo sapiens	85-89
27488030-7	2016	Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS.	Aminooxyacetic Acid	194-213	interleukin 6	Homo sapiens	319-323
27062388-10	2016	The reaction catalysed by GABA-T is inhibited by vigabatrin, whereas both GABA-T and AGXT2 activity is inhibited by aminooxyacetic acid (AOA).	Aminooxyacetic Acid	116-135	alanine--glyoxylate aminotransferase 2	Homo sapiens	85-90
27062388-10	2016	The reaction catalysed by GABA-T is inhibited by vigabatrin, whereas both GABA-T and AGXT2 activity is inhibited by aminooxyacetic acid (AOA).	Aminooxyacetic Acid	137-140	4-aminobutyrate aminotransferase	Homo sapiens	26-32
27062388-10	2016	The reaction catalysed by GABA-T is inhibited by vigabatrin, whereas both GABA-T and AGXT2 activity is inhibited by aminooxyacetic acid (AOA).	Aminooxyacetic Acid	137-140	4-aminobutyrate aminotransferase	Homo sapiens	74-80
27062388-10	2016	The reaction catalysed by GABA-T is inhibited by vigabatrin, whereas both GABA-T and AGXT2 activity is inhibited by aminooxyacetic acid (AOA).	Aminooxyacetic Acid	137-140	alanine--glyoxylate aminotransferase 2	Homo sapiens	85-90
27238370-2	2016	We recorded minute ventilation (VE), mean arterial pressure (MAP) and heart rate (HR) before and after blocking of enzyme Cystathionine beta-synthase (CBS) producing H2S in neural tissue by microinjection of aminooxyacetate (inhibitor of CBS) into the fourth ventricle of Wistar normotensive rats (WNR) and SHR followed by 30min of normoxia (21% inspired O2) or hypoxia (10% inspired O2) exposure.	Aminooxyacetic Acid	208-223	cystathionine beta synthase	Rattus norvegicus	122-149
27257787-0	2016	Cystathionine-beta-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach.	Aminooxyacetic Acid	88-107	cystathionine beta-synthase	Homo sapiens	0-27
27238370-2	2016	We recorded minute ventilation (VE), mean arterial pressure (MAP) and heart rate (HR) before and after blocking of enzyme Cystathionine beta-synthase (CBS) producing H2S in neural tissue by microinjection of aminooxyacetate (inhibitor of CBS) into the fourth ventricle of Wistar normotensive rats (WNR) and SHR followed by 30min of normoxia (21% inspired O2) or hypoxia (10% inspired O2) exposure.	Aminooxyacetic Acid	208-223	cystathionine beta synthase	Rattus norvegicus	151-154
26700431-6	2016	Both aminooxyacetic acid, an inhibitor of cystathionine-beta-synthase and glibenclamide, a KATP channel blocker reversed the inhibition of evoked NE release induced by the H2S donors.	Aminooxyacetic Acid	5-24	cystathionine beta-synthase	Bos taurus	42-69
27321283-5	2016	Moreover, aminooxyacetate, which inhibits the enzymatic activity of aminotransferases including GPT2, suppresses xenograft tumour growth of CRCs with PIK3CA mutations, but not with WT PIK3CA.	Aminooxyacetic Acid	10-25	glutamic--pyruvic transaminase 2	Homo sapiens	96-100
27321283-5	2016	Moreover, aminooxyacetate, which inhibits the enzymatic activity of aminotransferases including GPT2, suppresses xenograft tumour growth of CRCs with PIK3CA mutations, but not with WT PIK3CA.	Aminooxyacetic Acid	10-25	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	150-156
27022023-7	2016	Moreover, aminooxyacetic acid, a transaminase inhibitor, was able to potently suppress PGC-1alpha acetylation stimulated by methionine, which was accompanied by predicted alterations in PGC-1alpha-mediated gluconeogenic gene expression and glucose production in primary murine hepatocytes.	Aminooxyacetic Acid	10-29	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	87-97
27022023-7	2016	Moreover, aminooxyacetic acid, a transaminase inhibitor, was able to potently suppress PGC-1alpha acetylation stimulated by methionine, which was accompanied by predicted alterations in PGC-1alpha-mediated gluconeogenic gene expression and glucose production in primary murine hepatocytes.	Aminooxyacetic Acid	10-29	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	186-196
26192364-6	2015	Inhibition of the H2S producing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), with carboxymethoxylamine (AOA) and L-propargylglycine (PPG) enhanced ET-1 contractions.	Aminooxyacetic Acid	117-137	cystathionine beta-synthase	Homo sapiens	41-68
27042162-4	2016	THP1 differentiated macrophages were pretreated with the H2S donor NaHS (1 mM) or the H2S biosynthesis inhibitor aminooxyacetic acid (AOAA, 1 mM).	Aminooxyacetic Acid	113-132	GLI family zinc finger 2	Homo sapiens	0-4
27042162-4	2016	THP1 differentiated macrophages were pretreated with the H2S donor NaHS (1 mM) or the H2S biosynthesis inhibitor aminooxyacetic acid (AOAA, 1 mM).	Aminooxyacetic Acid	134-138	GLI family zinc finger 2	Homo sapiens	0-4
26192364-6	2015	Inhibition of the H2S producing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), with carboxymethoxylamine (AOA) and L-propargylglycine (PPG) enhanced ET-1 contractions.	Aminooxyacetic Acid	117-137	cystathionine gamma-lyase	Homo sapiens	79-104
26192364-6	2015	Inhibition of the H2S producing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), with carboxymethoxylamine (AOA) and L-propargylglycine (PPG) enhanced ET-1 contractions.	Aminooxyacetic Acid	117-137	cystathionine gamma-lyase	Homo sapiens	106-109
26201052-4	2015	The results obtained using ileum preparations and a model cell line (PC12 cells) with various amino acids and BCH showed that not only L-cysteine, but also aminooxyacetic acid and D,L-propargylglycine, which act as H2S synthesis inhibitors, appeared to be taken up by these preparations/cells in L and B (,+) system-dependent manners.	Aminooxyacetic Acid	156-175	chimerin 2	Mus musculus	110-113
26161999-0	2015	The Chaperoning Activity of Amino-oxyacetic Acid on Folding-Defective Variants of Human Alanine:Glyoxylate Aminotransferase Causing Primary Hyperoxaluria Type I.	Aminooxyacetic Acid	28-48	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	88-123
26161999-3	2015	In this report, we describe the interaction of amino-oxyacetic acid (AOA) with the recombinant purified form of two polymorphic species of AGT, AGT-Ma and AGT-Mi, and with three pathogenic variants bearing previously identified folding defects: G41R-Ma, G170R-Mi, and I244T-Mi.	Aminooxyacetic Acid	47-67	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	139-142
26161999-3	2015	In this report, we describe the interaction of amino-oxyacetic acid (AOA) with the recombinant purified form of two polymorphic species of AGT, AGT-Ma and AGT-Mi, and with three pathogenic variants bearing previously identified folding defects: G41R-Ma, G170R-Mi, and I244T-Mi.	Aminooxyacetic Acid	47-67	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	144-147
26161999-3	2015	In this report, we describe the interaction of amino-oxyacetic acid (AOA) with the recombinant purified form of two polymorphic species of AGT, AGT-Ma and AGT-Mi, and with three pathogenic variants bearing previously identified folding defects: G41R-Ma, G170R-Mi, and I244T-Mi.	Aminooxyacetic Acid	47-67	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	144-147
26161999-3	2015	In this report, we describe the interaction of amino-oxyacetic acid (AOA) with the recombinant purified form of two polymorphic species of AGT, AGT-Ma and AGT-Mi, and with three pathogenic variants bearing previously identified folding defects: G41R-Ma, G170R-Mi, and I244T-Mi.	Aminooxyacetic Acid	69-72	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	139-142
26161999-3	2015	In this report, we describe the interaction of amino-oxyacetic acid (AOA) with the recombinant purified form of two polymorphic species of AGT, AGT-Ma and AGT-Mi, and with three pathogenic variants bearing previously identified folding defects: G41R-Ma, G170R-Mi, and I244T-Mi.	Aminooxyacetic Acid	69-72	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	144-147
26161999-3	2015	In this report, we describe the interaction of amino-oxyacetic acid (AOA) with the recombinant purified form of two polymorphic species of AGT, AGT-Ma and AGT-Mi, and with three pathogenic variants bearing previously identified folding defects: G41R-Ma, G170R-Mi, and I244T-Mi.	Aminooxyacetic Acid	69-72	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	144-147
26087745-7	2015	The contraction of esophageal muscle strips was also measured after the inhibition of CBS and CSE by aminooxyacetic acid (AOA) and propargylglycine (PAG).	Aminooxyacetic Acid	101-120	cystathionine gamma-lyase	Oryctolagus cuniculus	94-97
26087745-7	2015	The contraction of esophageal muscle strips was also measured after the inhibition of CBS and CSE by aminooxyacetic acid (AOA) and propargylglycine (PAG).	Aminooxyacetic Acid	122-125	cystathionine gamma-lyase	Oryctolagus cuniculus	94-97
25599573-6	2015	Microinjection of the CBS inhibitors hydroxylamine (HA) or amino-oxyacetate into the RVLM produced an increase in the renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP), and HR.	Aminooxyacetic Acid	59-75	cystathionine beta synthase	Rattus norvegicus	22-25
25998884-8	2015	Moreover, our study has excluded the possibility that the major nonspecific effect of AOAA-inhibition of GABA transaminase-is involved in theses effects of AOAA.	Aminooxyacetic Acid	86-90	4-aminobutyrate aminotransferase	Mus musculus	105-122
25885215-9	2015	Systematic administration of O-(Carboxymethyl) hydroxylamine hemihydrochloride (AOAA), an inhibitor of CBS, suppressed the upregulation of P2X3R expression and the potentiation of ATP-induced intracellular calcium signals in DRG neurons (P < 0.05).	Aminooxyacetic Acid	80-84	cystathionine beta synthase	Rattus norvegicus	103-106
25008073-4	2014	ES-induced contractions were neurotoxin-sensitive and increased by aminooxyacetic acid, an inhibitor of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase, but not by D,L-propargylglycine, a selective inhibitor of cystathionine gamma-lyase, in an ES trial-dependent manner.	Aminooxyacetic Acid	67-86	cystathionine beta-synthase	Mus musculus	104-131
25662313-10	2015	In addition, administration of l-cysteine (1muM-3mM), the precursor of H2S, induced a modest relaxation response in PGF2alpha precontracted retinal arteries, which was significantly decreased in the presence of cystathionine-beta-synthase (CBS) inhibitor, aminooxyacetic acid, but was unmodified in the presence of the cystathionine-gamma-lyase (CSE) inhibitor, dl-propargylglycine or the deendothelization of retinal arteries.	Aminooxyacetic Acid	256-275	cystathionine beta-synthase	Bos taurus	211-238
25630260-4	2015	Conversely, other CSE antagonists tested, aminooxyacetic acid (AOAA, 100 mum), beta-cyanoalanine (BCA, 500 mum) and hydroxylamine (HA, 100 mum), altered the NPV to PGF2alpha (BCA increased, HA inhibited) and/or LY83583 (BCA increased, AOAA and HA inhibited).	Aminooxyacetic Acid	63-67	cystathionine gamma-lyase	Rattus norvegicus	18-21
25630260-4	2015	Conversely, other CSE antagonists tested, aminooxyacetic acid (AOAA, 100 mum), beta-cyanoalanine (BCA, 500 mum) and hydroxylamine (HA, 100 mum), altered the NPV to PGF2alpha (BCA increased, HA inhibited) and/or LY83583 (BCA increased, AOAA and HA inhibited).	Aminooxyacetic Acid	235-239	cystathionine gamma-lyase	Rattus norvegicus	18-21
24730679-5	2015	Next, the current state of the art of pharmacological CBS inhibitors is reviewed, with special reference to the complex pharmacological actions of aminooxyacetic acid.	Aminooxyacetic Acid	147-166	cystathionine beta-synthase	Homo sapiens	54-57
25042027-3	2014	METHODS: Cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) inhibitors (aminooxyacetate: AOA and propargylglycine: PAG respectively) and a H2S donor (sodium sulphide: Na2S) were microinjected into the fourth ventricle (4V).	Aminooxyacetic Acid	91-106	cystathionine gamma-lyase	Homo sapiens	74-77
24756639-4	2014	In adult zebrafish, inhibition of both CBS and CSE with aminooxyacetate (AOA) and propargyl glycine (PPG) blunted or abolished the hypoxic hyperventilation, and the addition of Na2S to the water partially rescued the effects of inhibiting endogenous H2S production.	Aminooxyacetic Acid	56-71	cystathionase (cystathionine gamma-lyase)	Danio rerio	47-50
24667534-12	2014	The short-term stimulatory effects of SAM were attenuated by the CBS inhibitor aminooxyacetic acid (AOAA) or by stable silencing of CBS.	Aminooxyacetic Acid	79-98	cystathionine beta-synthase	Homo sapiens	65-68
24667534-12	2014	The short-term stimulatory effects of SAM were attenuated by the CBS inhibitor aminooxyacetic acid (AOAA) or by stable silencing of CBS.	Aminooxyacetic Acid	100-104	cystathionine beta-synthase	Homo sapiens	65-68
24756639-4	2014	In adult zebrafish, inhibition of both CBS and CSE with aminooxyacetate (AOA) and propargyl glycine (PPG) blunted or abolished the hypoxic hyperventilation, and the addition of Na2S to the water partially rescued the effects of inhibiting endogenous H2S production.	Aminooxyacetic Acid	73-76	cystathionase (cystathionine gamma-lyase)	Danio rerio	47-50
24344772-7	2014	To verify this, we have produced two variants of the HER2-targeting ZHER2:342 Affibody molecule by peptide synthesis: OA-PEP4313, where aminooxyacetic acid was conjugated directly to the N-terminal alanine, and OA-E3-PEP4313, where a triglutamyl spacer was introduced between the aminooxy moiety and the N-terminus.	Aminooxyacetic Acid	136-155	erb-b2 receptor tyrosine kinase 2	Mus musculus	53-57
23801081-7	2013	The sensitivity of IDH1-R132H-expressing cells and IDH1 KD cells to ROS induction and cell death was further enhanced with the transaminase inhibitor aminooxyacetic acid and under glutamine free conditions, indicating that these cells were more addicted to glutaminolysis.	Aminooxyacetic Acid	150-169	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	19-23
23801081-7	2013	The sensitivity of IDH1-R132H-expressing cells and IDH1 KD cells to ROS induction and cell death was further enhanced with the transaminase inhibitor aminooxyacetic acid and under glutamine free conditions, indicating that these cells were more addicted to glutaminolysis.	Aminooxyacetic Acid	150-169	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	51-55
23449670-11	2013	Administration of O-(carboxymethyl)hydroxylamine hemihydrochloride (AOAA), an inhibitor for CBS, remarkably suppressed Na(+) current density and reduced expression of Na(V)1.7 and Na(V)1.8.	Aminooxyacetic Acid	68-72	cystathionine beta-synthase	Homo sapiens	92-95
24145109-9	2013	Both the inhibitors of cystathionine beta-synthase (aminooxyacetic acid, AOAA, 30 muM) and cystathionine gamma-lyase (propargylglycine, PAG, 1 mM) caused significant (p < 0.05) rightward shifts in the concentration-response curve to GYY4137.	Aminooxyacetic Acid	52-71	cystathionine beta-synthase	Bos taurus	23-50
24145109-9	2013	Both the inhibitors of cystathionine beta-synthase (aminooxyacetic acid, AOAA, 30 muM) and cystathionine gamma-lyase (propargylglycine, PAG, 1 mM) caused significant (p < 0.05) rightward shifts in the concentration-response curve to GYY4137.	Aminooxyacetic Acid	73-77	cystathionine beta-synthase	Bos taurus	23-50
23834820-9	2013	Pretreatment of O-(Carboxymethyl) hydroxylamine hemihydrochloride (AOAA), an inhibitor of CBS, significantly reduced expression of Na(V)1.8 in NMD rats.	Aminooxyacetic Acid	67-71	cystathionine beta synthase	Rattus norvegicus	90-93
23834820-9	2013	Pretreatment of O-(Carboxymethyl) hydroxylamine hemihydrochloride (AOAA), an inhibitor of CBS, significantly reduced expression of Na(V)1.8 in NMD rats.	Aminooxyacetic Acid	67-71	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	131-139
23836652-5	2013	ShRNA-mediated silencing of CBS or its pharmacological inhibition with aminooxyacetic acid reduced HCT116 cell proliferation, migration, and invasion; reduced endothelial cell migration in tumor/endothelial cell cocultures; and suppressed mitochondrial function (oxygen consumption, ATP turnover, and respiratory reserve capacity), as well as glycolysis.	Aminooxyacetic Acid	71-90	cystathionine beta-synthase	Homo sapiens	28-31
23488457-8	2013	On the other hand, aminooxyacetic acid (AOAA), a frequently used CBS inhibitor, was more potent in inhibiting CSE compared with BCA and PAG (IC50 1.1 +- 0.1 muM); the IC50 for AOAA for inhibiting CBS was 8.5 +- 0.7 muM.	Aminooxyacetic Acid	19-38	cystathionine beta-synthase	Homo sapiens	65-68
23488457-8	2013	On the other hand, aminooxyacetic acid (AOAA), a frequently used CBS inhibitor, was more potent in inhibiting CSE compared with BCA and PAG (IC50 1.1 +- 0.1 muM); the IC50 for AOAA for inhibiting CBS was 8.5 +- 0.7 muM.	Aminooxyacetic Acid	19-38	cystathionine beta-synthase	Homo sapiens	196-199
23488457-8	2013	On the other hand, aminooxyacetic acid (AOAA), a frequently used CBS inhibitor, was more potent in inhibiting CSE compared with BCA and PAG (IC50 1.1 +- 0.1 muM); the IC50 for AOAA for inhibiting CBS was 8.5 +- 0.7 muM.	Aminooxyacetic Acid	40-44	cystathionine beta-synthase	Homo sapiens	65-68
23488457-8	2013	On the other hand, aminooxyacetic acid (AOAA), a frequently used CBS inhibitor, was more potent in inhibiting CSE compared with BCA and PAG (IC50 1.1 +- 0.1 muM); the IC50 for AOAA for inhibiting CBS was 8.5 +- 0.7 muM.	Aminooxyacetic Acid	40-44	cystathionine beta-synthase	Homo sapiens	196-199
23449670-11	2013	Administration of O-(carboxymethyl)hydroxylamine hemihydrochloride (AOAA), an inhibitor for CBS, remarkably suppressed Na(+) current density and reduced expression of Na(V)1.7 and Na(V)1.8.	Aminooxyacetic Acid	68-72	sodium voltage-gated channel alpha subunit 9	Rattus norvegicus	167-188
23376738-3	2013	Moreover, pre-treatment with aminooxyacetic acid, the inhibitor of CBS or knockdown of CBS in using siRNA, significantly attenuated the effects of L-cysteine on elevated H2S levels and the cell proliferation; it also effectively suppressed L-cysteine-induced neurogenesis and astrocytogenesis.	Aminooxyacetic Acid	29-48	cystathionine beta-synthase	Homo sapiens	67-70
23376738-3	2013	Moreover, pre-treatment with aminooxyacetic acid, the inhibitor of CBS or knockdown of CBS in using siRNA, significantly attenuated the effects of L-cysteine on elevated H2S levels and the cell proliferation; it also effectively suppressed L-cysteine-induced neurogenesis and astrocytogenesis.	Aminooxyacetic Acid	29-48	cystathionine beta-synthase	Homo sapiens	87-90
23226735-9	2012	Pretreatment with the CBS inhibitor aminooxyacetic acid (AOAA) or CBS small interfering RNA (siRNA) decreased LPS-enhanced H(2)S production.	Aminooxyacetic Acid	36-55	cystathionine beta-synthase	Homo sapiens	22-25
23153577-4	2013	Intracerebroventricular (icv) microinjection of aminooxyacetate (AOA, a CBS inhibitor; 100 pmol) did not affect basal PGE(2) production and Tb, but enhanced LPS-induced PGE(2) production and fever, indicating that endogenous H(2)S plays an antipyretic role.	Aminooxyacetic Acid	48-63	cystathionine beta-synthase	Homo sapiens	72-75
23273102-4	2013	The CBS inhibitors hydroxylamine and aminooxyacetic acid attenuated mechanical hyperalgesia in a dose-dependent manner and reversed hyperexcitability of DRG neurons in inflamed rats.	Aminooxyacetic Acid	37-56	cystathionine beta synthase	Rattus norvegicus	4-7
23043860-7	2012	Incubation of the atria with propargylglycine (PAG, a cystathionine-gamma-lyase inhibitor) and amino-oxyacetic acid (AOAA, a cystathionine-beta-synthase inhibitor) was associated with a significant desensitization of chronotropic response to adrenergic stimulation in controls rats.	Aminooxyacetic Acid	95-115	cystathionine beta synthase	Rattus norvegicus	125-152
23043860-7	2012	Incubation of the atria with propargylglycine (PAG, a cystathionine-gamma-lyase inhibitor) and amino-oxyacetic acid (AOAA, a cystathionine-beta-synthase inhibitor) was associated with a significant desensitization of chronotropic response to adrenergic stimulation in controls rats.	Aminooxyacetic Acid	117-121	cystathionine beta synthase	Rattus norvegicus	125-152
23226735-9	2012	Pretreatment with the CBS inhibitor aminooxyacetic acid (AOAA) or CBS small interfering RNA (siRNA) decreased LPS-enhanced H(2)S production.	Aminooxyacetic Acid	57-61	cystathionine beta-synthase	Homo sapiens	22-25
23285261-9	2012	Administration of O-(Carboxymethyl)hydroxylamine hemihydrochloride (AOAA), an inhibitor of CBS, attenuated the AWR scores in HIS-treated rats, in a dose dependent fashion.	Aminooxyacetic Acid	68-72	cystathionine beta synthase	Rattus norvegicus	91-94
23133623-13	2012	Intraperitoneal injection (i.p) of DL-propargylglycine, an irreversible inhibitor of CSE, and aminooxyacetic acid, an inhibitor of CBS, elevated the expression of TNF-alpha mRNA in the tunica muscularis of the ileum.	Aminooxyacetic Acid	94-113	cystathionine beta-synthase	Mus musculus	131-134
23133623-13	2012	Intraperitoneal injection (i.p) of DL-propargylglycine, an irreversible inhibitor of CSE, and aminooxyacetic acid, an inhibitor of CBS, elevated the expression of TNF-alpha mRNA in the tunica muscularis of the ileum.	Aminooxyacetic Acid	94-113	tumor necrosis factor	Mus musculus	163-172
21766795-3	2011	We discovered that, while hydroxylamine can enter the retinal binding pocket of light-activated rhodopsin, the modified hydroxylamine compounds o-methylhydroxylamine (mHA), o-ethylhydroxylamine (eHA), o-tert-butylhydroxylamine (t-bHA), and o-(carboxymethyl)hydroxylamine (cmHA) are excluded.	Aminooxyacetic Acid	240-270	rhodopsin	Homo sapiens	96-105
21748658-6	2011	Inhibition of CBS activity by amino-oxyacetate and CBS silencing with a short hairpin RNA vector targeting rat CBS gene reversed the protective action of ADMA against MPP+-caused cytotoxicity, ROS overproduction, and MMP loss in PC12 cells.	Aminooxyacetic Acid	30-46	cystathionine beta synthase	Rattus norvegicus	14-17
21640784-2	2011	Aminooxyacetic acid hemihydrochloride (AOAA), an inhibitor of C-S lyase, reduced renal injuries due to cisplatin in rats, suggesting involvement of C-S lyase.	Aminooxyacetic Acid	39-43	kynurenine aminotransferase 1	Rattus norvegicus	62-71
21640784-2	2011	Aminooxyacetic acid hemihydrochloride (AOAA), an inhibitor of C-S lyase, reduced renal injuries due to cisplatin in rats, suggesting involvement of C-S lyase.	Aminooxyacetic Acid	39-43	kynurenine aminotransferase 1	Rattus norvegicus	148-157
22058949-1	2011	The title compound, C(7)H(13)NO(5), was prepared by the condensation of O-(carb-oxy-meth-yl)hydroxyl-amine and (Boc)(2)O (Boc = but-oxy-carbon-yl).In the crystal, mol-ecules are linked by weak inter-molecular N-H O hydrogen bonds.	Aminooxyacetic Acid	72-106	BOC cell adhesion associated, oncogene regulated	Homo sapiens	122-125
21766795-3	2011	We discovered that, while hydroxylamine can enter the retinal binding pocket of light-activated rhodopsin, the modified hydroxylamine compounds o-methylhydroxylamine (mHA), o-ethylhydroxylamine (eHA), o-tert-butylhydroxylamine (t-bHA), and o-(carboxymethyl)hydroxylamine (cmHA) are excluded.	Aminooxyacetic Acid	272-276	rhodopsin	Homo sapiens	96-105
20025971-5	2010	Amino-oxyacetate that inhibits the malate-aspartate shuttle caused a similar increase in VEGF mRNA and impaired response to H(2)O(2) in WT-hSOD1 expressing cells.	Aminooxyacetic Acid	0-16	vascular endothelial growth factor A	Mus musculus	89-93
21952317-4	2011	Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced.	Aminooxyacetic Acid	93-112	cystathionine gamma-lyase	Homo sapiens	163-188
21952317-4	2011	Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced.	Aminooxyacetic Acid	114-118	cystathionine gamma-lyase	Homo sapiens	163-188
21952317-4	2011	Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced.	Aminooxyacetic Acid	114-118	cystathionine gamma-lyase	Homo sapiens	190-193
21952317-4	2011	Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced.	Aminooxyacetic Acid	114-118	cystathionine beta-synthase	Homo sapiens	199-226
21952317-4	2011	Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced.	Aminooxyacetic Acid	114-118	cystathionine beta-synthase	Homo sapiens	228-231
21952317-4	2011	Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced.	Aminooxyacetic Acid	114-118	caspase 3	Homo sapiens	323-332
20923481-7	2010	The pan transaminase inhibitor amino-oxyacetate reversed HADHSC knockdown-mediated increases in GSIS.	Aminooxyacetic Acid	31-47	hydroxyacyl-CoA dehydrogenase	Rattus norvegicus	57-63
20025971-5	2010	Amino-oxyacetate that inhibits the malate-aspartate shuttle caused a similar increase in VEGF mRNA and impaired response to H(2)O(2) in WT-hSOD1 expressing cells.	Aminooxyacetic Acid	0-16	superoxide dismutase 1	Homo sapiens	139-144
19246614-4	2009	This H(2)S production was completely abolished by inhibition of both cystathionine beta-synthetase (CBS) and cystathionine gamma-lyase (CGL), two major enzymes for the production of H(2)S, using amino-oxyacetic acid (AOAA), an inhibitor of CBS, and propargylglycine (PPG), an inhibitor of CGL.	Aminooxyacetic Acid	195-215	cystathionine gamma-lyase	Homo sapiens	109-134
19246614-4	2009	This H(2)S production was completely abolished by inhibition of both cystathionine beta-synthetase (CBS) and cystathionine gamma-lyase (CGL), two major enzymes for the production of H(2)S, using amino-oxyacetic acid (AOAA), an inhibitor of CBS, and propargylglycine (PPG), an inhibitor of CGL.	Aminooxyacetic Acid	217-221	cystathionine gamma-lyase	Homo sapiens	109-134
18987290-4	2009	In both tissues, the production of H(2)S was eliminated by adding the cystathionine beta-synthase inhibitor, aminooxyacetate.	Aminooxyacetic Acid	109-124	cystathionine-beta-synthase	Oncorhynchus mykiss	70-97
18629636-5	2009	The inhibitory action of H2S donors on NE release was attenuated by aminooxyacetic acid (AOA) and propargyglycine (PAG), inhibitors of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), respectively.	Aminooxyacetic Acid	68-87	cystathionine beta-synthase	Homo sapiens	135-162
18629636-5	2009	The inhibitory action of H2S donors on NE release was attenuated by aminooxyacetic acid (AOA) and propargyglycine (PAG), inhibitors of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), respectively.	Aminooxyacetic Acid	68-87	cystathionine gamma-lyase	Homo sapiens	200-203
18629636-5	2009	The inhibitory action of H2S donors on NE release was attenuated by aminooxyacetic acid (AOA) and propargyglycine (PAG), inhibitors of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), respectively.	Aminooxyacetic Acid	89-92	cystathionine beta-synthase	Homo sapiens	164-167
18629636-5	2009	The inhibitory action of H2S donors on NE release was attenuated by aminooxyacetic acid (AOA) and propargyglycine (PAG), inhibitors of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), respectively.	Aminooxyacetic Acid	89-92	cystathionine gamma-lyase	Homo sapiens	173-198
18629636-5	2009	The inhibitory action of H2S donors on NE release was attenuated by aminooxyacetic acid (AOA) and propargyglycine (PAG), inhibitors of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), respectively.	Aminooxyacetic Acid	89-92	cystathionine gamma-lyase	Homo sapiens	200-203