PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 29652261-3 2018 In this study, the dynamics of the active site and the communication paths between the substrates, ATP and TMP, are reported for thymidylate kinase from Thermus thermophilus. Thymidine Monophosphate 107-110 deoxythymidylate kinase Homo sapiens 129-147 29922516-14 2018 Overall, the experimental results also suggest that in the VAAP clade the nucleotide salvage pathway is important and should be investigated, since the de novo dTMP synthesis appears to be compromised by a less efficient thymidylate synthase. Thymidine Monophosphate 160-164 thymidylate synthetase Homo sapiens 221-241 29671583-2 2018 Using a photocaged TMP-Haloligand compound, we demonstrate small molecule and light-induced dimerization of DHFR and Haloenzyme to localize proteins to a compartment boundary and reconstitute tripartite sfGFP assembly. Thymidine Monophosphate 19-22 dihydrofolate reductase Homo sapiens 108-112 29735940-1 2018 Thymidylate synthase (TYMS) is an essential enzyme for the de novo synthesis of deoxythymidine monophosphate (dTMP) and has been a primary target for cancer chemotherapy. Thymidine Monophosphate 80-108 thymidylate synthetase Homo sapiens 0-20 29735940-1 2018 Thymidylate synthase (TYMS) is an essential enzyme for the de novo synthesis of deoxythymidine monophosphate (dTMP) and has been a primary target for cancer chemotherapy. Thymidine Monophosphate 80-108 thymidylate synthetase Homo sapiens 22-26 29735940-1 2018 Thymidylate synthase (TYMS) is an essential enzyme for the de novo synthesis of deoxythymidine monophosphate (dTMP) and has been a primary target for cancer chemotherapy. Thymidine Monophosphate 110-114 thymidylate synthetase Homo sapiens 0-20 29735940-1 2018 Thymidylate synthase (TYMS) is an essential enzyme for the de novo synthesis of deoxythymidine monophosphate (dTMP) and has been a primary target for cancer chemotherapy. Thymidine Monophosphate 110-114 thymidylate synthetase Homo sapiens 22-26 29735940-2 2018 Although the physical structure of TYMS and the molecular mechanisms of TYMS catalyzing the conversion of deoxyuridine monophosphate (dUMP) to dTMP have been the subject of thorough studies, its oligomeric structure remains unclear. Thymidine Monophosphate 143-147 thymidylate synthetase Homo sapiens 35-39 29735940-2 2018 Although the physical structure of TYMS and the molecular mechanisms of TYMS catalyzing the conversion of deoxyuridine monophosphate (dUMP) to dTMP have been the subject of thorough studies, its oligomeric structure remains unclear. Thymidine Monophosphate 143-147 thymidylate synthetase Homo sapiens 72-76 29735940-5 2018 Using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), we have shown that purified TYMS has catalytic activity for producing dTMP. Thymidine Monophosphate 154-158 thymidylate synthetase Homo sapiens 112-116 29331423-0 2018 Thymidylate synthase prompts metastatic progression through the dTMP associated EMT process in pancreatic ductal adenocarcinoma. Thymidine Monophosphate 64-68 thymidylate synthetase Homo sapiens 0-20 29331423-0 2018 Thymidylate synthase prompts metastatic progression through the dTMP associated EMT process in pancreatic ductal adenocarcinoma. Thymidine Monophosphate 64-68 IL2 inducible T cell kinase Mus musculus 80-83 29978863-4 2018 In the second, the highly crowded iminoborane Ter-NB-TMP (TMP = 2,2,6,6-tetramethylpiperidyl, Ter = 2,6-(diphenylmethyl)-4-tert-butylphenyl) can be forced to react with Pip-CC-Pip (Pip = piperidyl) at 60 C. The reaction product is the apparent result of Pip-CC insertion into the iminoborane BN bond. Thymidine Monophosphate 53-56 prolactin induced protein Homo sapiens 169-172 29978863-4 2018 In the second, the highly crowded iminoborane Ter-NB-TMP (TMP = 2,2,6,6-tetramethylpiperidyl, Ter = 2,6-(diphenylmethyl)-4-tert-butylphenyl) can be forced to react with Pip-CC-Pip (Pip = piperidyl) at 60 C. The reaction product is the apparent result of Pip-CC insertion into the iminoborane BN bond. Thymidine Monophosphate 53-56 prolactin induced protein Homo sapiens 176-179 29978863-4 2018 In the second, the highly crowded iminoborane Ter-NB-TMP (TMP = 2,2,6,6-tetramethylpiperidyl, Ter = 2,6-(diphenylmethyl)-4-tert-butylphenyl) can be forced to react with Pip-CC-Pip (Pip = piperidyl) at 60 C. The reaction product is the apparent result of Pip-CC insertion into the iminoborane BN bond. Thymidine Monophosphate 53-56 prolactin induced protein Homo sapiens 176-179 29978863-4 2018 In the second, the highly crowded iminoborane Ter-NB-TMP (TMP = 2,2,6,6-tetramethylpiperidyl, Ter = 2,6-(diphenylmethyl)-4-tert-butylphenyl) can be forced to react with Pip-CC-Pip (Pip = piperidyl) at 60 C. The reaction product is the apparent result of Pip-CC insertion into the iminoborane BN bond. Thymidine Monophosphate 53-56 prolactin induced protein Homo sapiens 176-179 28350247-1 2017 Dihydrofolate reductase (DHFR) reduces folic acid and recycles dihydrofolate generated during dTMP biosynthesis to tetrahydrofolate. Thymidine Monophosphate 94-98 dihydrofolate reductase Danio rerio 0-23 28980375-1 2017 A triaminotriborane(3) was isolated as purple crystals through the reduction of (TMP)BCl2 (TMP=2,2,6,6-tetramethylpiperidino) by sodium naphthalenide. Thymidine Monophosphate 81-84 BCL2 apoptosis regulator Homo sapiens 85-89 28980375-1 2017 A triaminotriborane(3) was isolated as purple crystals through the reduction of (TMP)BCl2 (TMP=2,2,6,6-tetramethylpiperidino) by sodium naphthalenide. Thymidine Monophosphate 91-94 BCL2 apoptosis regulator Homo sapiens 85-89 28710931-7 2017 Further analysis revealed that TMP treatment upregulated expression of several proteins involved in cysteine biosynthesis including methionine adenosyltransferases (MATs) and cystathionine-beta-synthase (CBS). Thymidine Monophosphate 31-34 cystathionine beta synthase Rattus norvegicus 175-202 28634233-1 2017 Thymidylate synthase (TS) is the sole enzyme responsible for de novo biosynthesis of thymidylate (TMP) and is essential for cell proliferation and survival. Thymidine Monophosphate 98-101 thymidylate synthetase Homo sapiens 0-20 28634233-1 2017 Thymidylate synthase (TS) is the sole enzyme responsible for de novo biosynthesis of thymidylate (TMP) and is essential for cell proliferation and survival. Thymidine Monophosphate 98-101 APC down-regulated 1 Homo sapiens 22-24 28634233-7 2017 On the basis of these findings, we propose a regulatory mechanism of hTS activity that involves allosteric regulation of interactions of hTS with its own mRNA depending on cellular demands for TMP. Thymidine Monophosphate 193-196 APC down-regulated 1 Homo sapiens 69-72 28634233-7 2017 On the basis of these findings, we propose a regulatory mechanism of hTS activity that involves allosteric regulation of interactions of hTS with its own mRNA depending on cellular demands for TMP. Thymidine Monophosphate 193-196 APC down-regulated 1 Homo sapiens 137-140 28794642-1 2017 Mitochondrial serine hydroxyl-methyltransferase 2 (SHMT2), participating in the synthesis of mitochondrial thymidine monophosphate, has been reported to drive glioma cell survival in ischemia. Thymidine Monophosphate 107-130 serine hydroxymethyltransferase 2 Homo sapiens 14-49 28934497-3 2017 Mutations in nucleotide excision repair (NER) components (e.g. XPA-1 and XPF-1) imparted extreme sensitivity to TMP/UVA relative to wild-type animals, manifested as developmental arrest, defects in adult tissue morphology and functionality, and shortened lifespan. Thymidine Monophosphate 112-115 XPA_C domain-containing protein Caenorhabditis elegans 63-68 28934497-3 2017 Mutations in nucleotide excision repair (NER) components (e.g. XPA-1 and XPF-1) imparted extreme sensitivity to TMP/UVA relative to wild-type animals, manifested as developmental arrest, defects in adult tissue morphology and functionality, and shortened lifespan. Thymidine Monophosphate 112-115 ERCC4 domain-containing protein Caenorhabditis elegans 73-78 28551771-10 2017 Co-treatment of TMP HCl and PF could enhance the vessel sprouting in chemical-induced vascular insuffificiency zebrafifish at the optimal compatibility proportion of PF 10 mumol/L with TMP HCl 1 mumol/L. Thymidine Monophosphate 16-19 Brown hair color Homo sapiens 189-194 28763485-6 2017 The maternal exposure to SMZ/TMP significantly lowered the incidence of jaundice and bile duct obstruction and resulted in improved survival, especially in Cxcr2-/- mice. Thymidine Monophosphate 29-32 chemokine (C-X-C motif) receptor 2 Mus musculus 156-161 28763485-9 2017 When treated with SMZ/TMP, Cxcr2-/- mice infected with RRV to induce experimental biliary atresia showed further enrichment of Corynebacterium, Anaerococcus and Streptococcus. Thymidine Monophosphate 22-25 chemokine (C-X-C motif) receptor 2 Mus musculus 27-32 28794642-1 2017 Mitochondrial serine hydroxyl-methyltransferase 2 (SHMT2), participating in the synthesis of mitochondrial thymidine monophosphate, has been reported to drive glioma cell survival in ischemia. Thymidine Monophosphate 107-130 serine hydroxymethyltransferase 2 Homo sapiens 51-56 28580921-1 2017 Human thymidylate synthase (hTS) provides the sole de novo intracellular source of thymidine 5"-monophosphate (dTMP). Thymidine Monophosphate 83-109 thymidylate synthetase Homo sapiens 6-26 28580921-1 2017 Human thymidylate synthase (hTS) provides the sole de novo intracellular source of thymidine 5"-monophosphate (dTMP). Thymidine Monophosphate 83-109 APC down-regulated 1 Homo sapiens 28-31 28580921-1 2017 Human thymidylate synthase (hTS) provides the sole de novo intracellular source of thymidine 5"-monophosphate (dTMP). Thymidine Monophosphate 111-115 thymidylate synthetase Homo sapiens 6-26 28580921-1 2017 Human thymidylate synthase (hTS) provides the sole de novo intracellular source of thymidine 5"-monophosphate (dTMP). Thymidine Monophosphate 111-115 APC down-regulated 1 Homo sapiens 28-31 28350247-1 2017 Dihydrofolate reductase (DHFR) reduces folic acid and recycles dihydrofolate generated during dTMP biosynthesis to tetrahydrofolate. Thymidine Monophosphate 94-98 dihydrofolate reductase Danio rerio 25-29 28318037-3 2017 Molecular bypass therapy with the TK2 products, deoxycytidine monophosphate (dCMP) and deoxythymidine monophosphate (dTMP), prolongs the life span of Tk2-deficient (Tk2-/- ) mice by 2- to 3-fold. Thymidine Monophosphate 87-115 thymidine kinase 2, mitochondrial Mus musculus 150-153 28461497-8 2017 These studies also revealed that 5-formylTHF, a slow, tight-binding inhibitor of serine hydroxymethyltransferase (SHMT), was enriched in nuclei, accounting for 35% of folate cofactors, explaining previous observations that nuclear SHMT is not a robust source of one-carbons for de novo dTMP biosynthesis. Thymidine Monophosphate 286-290 serine hydroxymethyltransferase 1 Homo sapiens 114-118 28318037-3 2017 Molecular bypass therapy with the TK2 products, deoxycytidine monophosphate (dCMP) and deoxythymidine monophosphate (dTMP), prolongs the life span of Tk2-deficient (Tk2-/- ) mice by 2- to 3-fold. Thymidine Monophosphate 117-121 thymidine kinase 2, mitochondrial Mus musculus 34-37 28318037-3 2017 Molecular bypass therapy with the TK2 products, deoxycytidine monophosphate (dCMP) and deoxythymidine monophosphate (dTMP), prolongs the life span of Tk2-deficient (Tk2-/- ) mice by 2- to 3-fold. Thymidine Monophosphate 117-121 thymidine kinase 2, mitochondrial Mus musculus 150-153 28318037-7 2017 In contrast, dCMP+dTMP+THU therapy decreased life span of Tk2-/- animals compared to dCMP+dTMP. Thymidine Monophosphate 18-22 thymidine kinase 2, mitochondrial Mus musculus 58-61 27748121-1 2016 Targeting thymidylate kinase (TMPK) that catalyzes the phosphotransfer reaction for formation of dTDP from dTMP is a new strategy for anticancer treatment. Thymidine Monophosphate 107-111 deoxythymidylate kinase Homo sapiens 10-28 28400561-2 2017 Mouse models of folate-responsive neural tube defects (NTDs) indicate that impaired de novo thymidylate (dTMP) synthesis through changes in SHMT expression is causative in folate-responsive NTDs. Thymidine Monophosphate 105-109 serine hydroxymethyltransferase 1 (soluble) Mus musculus 140-144 28400561-5 2017 This computational model shows that de novo dTMP synthesis is highly sensitive to the common MTHFR C677T polymorphism and that the effect of the polymorphism on FOCM is greater in folate deficiency. Thymidine Monophosphate 44-48 methylenetetrahydrofolate reductase Homo sapiens 93-98 28300234-0 2017 Structural and transport properties of neutral radical crystals of CoIII(tmp)(CN)2 (tmp = 5,10,15,20-tetramethylporphyrinato) and the CN-bridged polymer [CoIII(tmp)(CN)]n. An axially ligated Co(tmp) (tmp = 5,10,15,20-tetramethylporphyrinato) anion, [CoIII(tmp)(CN)2]-, has been prepared and subjected to electrochemical oxidation to obtain the open shell tmp pi-ligand. Thymidine Monophosphate 73-76 mitochondrially encoded cytochrome c oxidase III Homo sapiens 67-72 28228507-5 2017 dTMP synthesis was quantified as the ratio of [14C]-deoxyuridine to [3H]-thymidine incorporation into genomic DNA, which indicates the capacity of de novo dTMP synthesis relative to salvage synthesis.Results: The [14C]-formate-to-[3H]-hypoxanthine ratio was greater in ADH5 knockout than in wild-type HepG2 cells, under conditions of both folate deficiency (+30%; P < 0.001) and folate sufficiency (+22%; P = 0.02). Thymidine Monophosphate 0-4 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 269-273 28265077-3 2017 Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and serine hydroxymethyltransferase (SHMT) generate 5,10-methylenetetrahydrofolate for de novo dTMP biosynthesis and translocate to the nucleus during S-phase, where they form a multienzyme complex with thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR), as well as the components of the DNA replication machinery. Thymidine Monophosphate 146-150 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Homo sapiens 0-41 28265077-3 2017 Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and serine hydroxymethyltransferase (SHMT) generate 5,10-methylenetetrahydrofolate for de novo dTMP biosynthesis and translocate to the nucleus during S-phase, where they form a multienzyme complex with thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR), as well as the components of the DNA replication machinery. Thymidine Monophosphate 146-150 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Homo sapiens 43-49 28265077-3 2017 Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and serine hydroxymethyltransferase (SHMT) generate 5,10-methylenetetrahydrofolate for de novo dTMP biosynthesis and translocate to the nucleus during S-phase, where they form a multienzyme complex with thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR), as well as the components of the DNA replication machinery. Thymidine Monophosphate 146-150 serine hydroxymethyltransferase 1 Homo sapiens 55-86 28265077-3 2017 Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and serine hydroxymethyltransferase (SHMT) generate 5,10-methylenetetrahydrofolate for de novo dTMP biosynthesis and translocate to the nucleus during S-phase, where they form a multienzyme complex with thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR), as well as the components of the DNA replication machinery. Thymidine Monophosphate 146-150 serine hydroxymethyltransferase 1 Homo sapiens 88-92 28265077-3 2017 Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and serine hydroxymethyltransferase (SHMT) generate 5,10-methylenetetrahydrofolate for de novo dTMP biosynthesis and translocate to the nucleus during S-phase, where they form a multienzyme complex with thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR), as well as the components of the DNA replication machinery. Thymidine Monophosphate 146-150 thymidylate synthetase Homo sapiens 254-274 28265077-3 2017 Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and serine hydroxymethyltransferase (SHMT) generate 5,10-methylenetetrahydrofolate for de novo dTMP biosynthesis and translocate to the nucleus during S-phase, where they form a multienzyme complex with thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR), as well as the components of the DNA replication machinery. Thymidine Monophosphate 146-150 thymidylate synthetase Homo sapiens 276-280 28265077-3 2017 Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and serine hydroxymethyltransferase (SHMT) generate 5,10-methylenetetrahydrofolate for de novo dTMP biosynthesis and translocate to the nucleus during S-phase, where they form a multienzyme complex with thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR), as well as the components of the DNA replication machinery. Thymidine Monophosphate 146-150 dihydrofolate reductase Homo sapiens 286-309 28265077-3 2017 Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and serine hydroxymethyltransferase (SHMT) generate 5,10-methylenetetrahydrofolate for de novo dTMP biosynthesis and translocate to the nucleus during S-phase, where they form a multienzyme complex with thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR), as well as the components of the DNA replication machinery. Thymidine Monophosphate 146-150 dihydrofolate reductase Homo sapiens 311-315 28265077-6 2017 These results demonstrate that MTHFD1 and SHMT1, which are key enzymes providing one-carbon units for dTMP biosynthesis in the form of 5,10-methylenetetrahydrofolate, are direct targets of As2O3-induced proteolytic degradation, providing a mechanism for arsenic in the etiology of cancer and developmental anomalies. Thymidine Monophosphate 102-106 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Homo sapiens 31-37 28265077-6 2017 These results demonstrate that MTHFD1 and SHMT1, which are key enzymes providing one-carbon units for dTMP biosynthesis in the form of 5,10-methylenetetrahydrofolate, are direct targets of As2O3-induced proteolytic degradation, providing a mechanism for arsenic in the etiology of cancer and developmental anomalies. Thymidine Monophosphate 102-106 serine hydroxymethyltransferase 1 Homo sapiens 42-47 28895423-1 2017 Thymidylate synthetase (TS) plays a critical role in the de novo synthesis of dTMP inside the cell. Thymidine Monophosphate 78-82 thymidylate synthetase Homo sapiens 0-22 27936107-3 2016 Thymidylate synthase catalyzes the conversion of 2"-deoxyuridine-5"-monophosphate (dUMP) to thymidine-5"-monophosphate (dTMP) using 5,10-methylenetetrahydrofolate (mTHF) as a co-substrate. Thymidine Monophosphate 92-118 thymidylate synthetase Homo sapiens 0-20 27936107-3 2016 Thymidylate synthase catalyzes the conversion of 2"-deoxyuridine-5"-monophosphate (dUMP) to thymidine-5"-monophosphate (dTMP) using 5,10-methylenetetrahydrofolate (mTHF) as a co-substrate. Thymidine Monophosphate 120-124 thymidylate synthetase Homo sapiens 0-20 27748121-1 2016 Targeting thymidylate kinase (TMPK) that catalyzes the phosphotransfer reaction for formation of dTDP from dTMP is a new strategy for anticancer treatment. Thymidine Monophosphate 107-111 deoxythymidylate kinase Homo sapiens 30-34 27748121-1 2016 Targeting thymidylate kinase (TMPK) that catalyzes the phosphotransfer reaction for formation of dTDP from dTMP is a new strategy for anticancer treatment. Thymidine Monophosphate 107-111 TAR DNA-binding protein-43 homolog Drosophila melanogaster 97-101 26073451-1 2016 In X-linked hypophosphatemia (XLH), serum fibroblast growth factor 23 (FGF23) is increased and results in reduced renal maximum threshold for phosphate reabsorption (TmP), reduced serum inorganic phosphorus (Pi), and inappropriately low normal serum 1,25 dihydroxyvitamin D (1,25[OH]2 D) concentration, with subsequent development of rickets or osteomalacia. Thymidine Monophosphate 166-169 fibroblast growth factor 23 Homo sapiens 42-69 27354219-9 2016 The TMP-injected Tlr9(-/-) mice, and not the wild-type mice, also develop a marked increase in glomerular IgG deposition and infiltrating granulocytes, much more severe glomerulonephritis, and a reduced lifespan. Thymidine Monophosphate 4-7 toll-like receptor 9 Mus musculus 17-21 27026843-2 2016 TYMS is a key enzyme for de novo synthesis of deoxythymidine monophosphate and subsequent synthesis of DNA. Thymidine Monophosphate 46-74 thymidylate synthetase Homo sapiens 0-4 27630985-6 2016 In the present study, a novel peptidic TPO mimetic was designed through computational studies by studying the binding sites of TPO and TMP to TPOR and analogs of known mimetics. Thymidine Monophosphate 135-138 thrombopoietin Homo sapiens 39-42 27630985-6 2016 In the present study, a novel peptidic TPO mimetic was designed through computational studies by studying the binding sites of TPO and TMP to TPOR and analogs of known mimetics. Thymidine Monophosphate 135-138 MPL proto-oncogene, thrombopoietin receptor Homo sapiens 142-146 26073451-1 2016 In X-linked hypophosphatemia (XLH), serum fibroblast growth factor 23 (FGF23) is increased and results in reduced renal maximum threshold for phosphate reabsorption (TmP), reduced serum inorganic phosphorus (Pi), and inappropriately low normal serum 1,25 dihydroxyvitamin D (1,25[OH]2 D) concentration, with subsequent development of rickets or osteomalacia. Thymidine Monophosphate 166-169 fibroblast growth factor 23 Homo sapiens 71-76 26443810-1 2015 Thymidylate synthase (TYMS; EC 2.1.1.15) catalyzes the reductive methylation of 2"-deoxyuridine-5"-monophosphate (dUMP) by N(5),N(10)-methyhlenetetrahydrofolate, forming dTMP for the maintenance of DNA replication and repair. Thymidine Monophosphate 170-174 thymidylate synthetase Homo sapiens 0-20 26630264-2 2015 VZV encodes a functional thymidylate synthase (TS), which is the sole enzyme that produces dTMP from dUMP de novo. Thymidine Monophosphate 91-95 thymidylate synthase Human alphaherpesvirus 3 25-45 26443810-1 2015 Thymidylate synthase (TYMS; EC 2.1.1.15) catalyzes the reductive methylation of 2"-deoxyuridine-5"-monophosphate (dUMP) by N(5),N(10)-methyhlenetetrahydrofolate, forming dTMP for the maintenance of DNA replication and repair. Thymidine Monophosphate 170-174 thymidylate synthetase Homo sapiens 22-26 25997777-1 2015 Inspired by TSase catalysis for dUMP conversion to dTMP, a biomodel reagent is developed. Thymidine Monophosphate 51-55 thymidylate synthetase Homo sapiens 12-17 26315341-3 2015 Thymidyne monophosphate kinase (TMK) is the enzyme in the junction of both pathways, which phosphorylates dTMP to yield deoxythymidine diphosphate (dTDP) using adenosine triphosphate (ATP) as a phosphate donor. Thymidine Monophosphate 106-110 TAR DNA-binding protein-43 homolog Drosophila melanogaster 148-152 26315341-6 2015 We found that TMKwssv can phosphorylate dTMP to yield dTDP and also is able to use dTDP as a substrate to produce dTTP. Thymidine Monophosphate 40-44 TAR DNA-binding protein-43 homolog Drosophila melanogaster 54-58 26315341-6 2015 We found that TMKwssv can phosphorylate dTMP to yield dTDP and also is able to use dTDP as a substrate to produce dTTP. Thymidine Monophosphate 40-44 TAR DNA-binding protein-43 homolog Drosophila melanogaster 83-87 26087398-10 2015 This is the first demonstration of a direct role for TK2 in gemcitabine resistance, or any independent role in cancer drug resistance, and further distinguishes TK2 function from that of other dTMP-producing enzymes [cytosolic TK1 and thymidylate synthase (TS)]. Thymidine Monophosphate 193-197 thymidine kinase 2 Homo sapiens 161-164 27123375-4 2015 MTHFD1 has been shown to translocate to the nucleus during S-phase of the cell cycle; this localization is critical for synthesis of thymidyate (dTMP or the "T" base in DNA) and subsequent progression through the cell cycle and cell proliferation. Thymidine Monophosphate 145-149 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Homo sapiens 0-6 27123375-5 2015 Identification of MTHFD1 mutations that are associated with SCID highlights the potential importance of adequate dTMP synthesis in the etiology of SCID. Thymidine Monophosphate 113-117 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Homo sapiens 18-24 26088147-7 2015 TNF-alpha levels, CD31+ EMPs, and protein expression of ROCK II and TLR4 were significantly decreased in the TMP group compared with the LPS group (P<0.01). Thymidine Monophosphate 109-112 tumor necrosis factor Rattus norvegicus 0-9 26088147-7 2015 TNF-alpha levels, CD31+ EMPs, and protein expression of ROCK II and TLR4 were significantly decreased in the TMP group compared with the LPS group (P<0.01). Thymidine Monophosphate 109-112 platelet and endothelial cell adhesion molecule 1 Rattus norvegicus 18-22 26088147-7 2015 TNF-alpha levels, CD31+ EMPs, and protein expression of ROCK II and TLR4 were significantly decreased in the TMP group compared with the LPS group (P<0.01). Thymidine Monophosphate 109-112 Rho-associated coiled-coil containing protein kinase 2 Rattus norvegicus 56-63 26088147-7 2015 TNF-alpha levels, CD31+ EMPs, and protein expression of ROCK II and TLR4 were significantly decreased in the TMP group compared with the LPS group (P<0.01). Thymidine Monophosphate 109-112 toll-like receptor 4 Rattus norvegicus 68-72 26088147-8 2015 This study demonstrated that TMP can alleviate LPS-induced pulmonary damage by attenuating pulmonary vascular permeability and CD31+ EMP levels in the plasma, reducing the release of the inflammatory mediator TNF-alpha and inhibiting the protein expression of ROCK II and TLR4. Thymidine Monophosphate 29-32 platelet and endothelial cell adhesion molecule 1 Rattus norvegicus 127-131 26088147-8 2015 This study demonstrated that TMP can alleviate LPS-induced pulmonary damage by attenuating pulmonary vascular permeability and CD31+ EMP levels in the plasma, reducing the release of the inflammatory mediator TNF-alpha and inhibiting the protein expression of ROCK II and TLR4. Thymidine Monophosphate 29-32 tumor necrosis factor Rattus norvegicus 209-218 26088147-8 2015 This study demonstrated that TMP can alleviate LPS-induced pulmonary damage by attenuating pulmonary vascular permeability and CD31+ EMP levels in the plasma, reducing the release of the inflammatory mediator TNF-alpha and inhibiting the protein expression of ROCK II and TLR4. Thymidine Monophosphate 29-32 Rho-associated coiled-coil containing protein kinase 2 Rattus norvegicus 260-267 26088147-8 2015 This study demonstrated that TMP can alleviate LPS-induced pulmonary damage by attenuating pulmonary vascular permeability and CD31+ EMP levels in the plasma, reducing the release of the inflammatory mediator TNF-alpha and inhibiting the protein expression of ROCK II and TLR4. Thymidine Monophosphate 29-32 toll-like receptor 4 Rattus norvegicus 272-276 25152750-1 2014 Thymidine kinase 1 (TK1) is a salvage enzyme that phosphorylates thymidine, imported from surrounding fluids, to create dTMP, which is further phosphorylated to the DNA precursor dTTP. Thymidine Monophosphate 120-124 thymidine kinase 1 Homo sapiens 20-23 25557296-10 2015 Pharmacological inhibition of AKT following MI and prior to DT1 challenge significantly decreased the cardioprotection afforded by DT1 therapy at reperfusion. Thymidine Monophosphate 131-134 AKT serine/threonine kinase 1 Rattus norvegicus 30-33 25505243-10 2015 In summary, these data, taken together, suggest that the thymidine salvage pathway is compartmentalized so that TMP kinase prefers TMP synthesized by TK2 over medium TMP and that this is disrupted in broken mitochondria. Thymidine Monophosphate 112-115 thymidine kinase 2 Rattus norvegicus 150-153 25505243-10 2015 In summary, these data, taken together, suggest that the thymidine salvage pathway is compartmentalized so that TMP kinase prefers TMP synthesized by TK2 over medium TMP and that this is disrupted in broken mitochondria. Thymidine Monophosphate 131-134 thymidine kinase 2 Rattus norvegicus 150-153 26677577-6 2015 N4-hydroxy-dCMP analogues exhibited very interesting inhibitory properties versus the biosynthesis of dTMP catalyzed by thymidylate synthase. Thymidine Monophosphate 102-106 thymidylate synthetase Homo sapiens 120-140 25581782-3 2015 Thymidylate synthase (TSase) is unique in this context because it is the only enzyme in humans that is responsible for the de novo biosynthesis of the DNA building block 2"-deoxy-thymidylate (dTMP). Thymidine Monophosphate 192-196 thymidylate synthetase Homo sapiens 0-20 25581782-3 2015 Thymidylate synthase (TSase) is unique in this context because it is the only enzyme in humans that is responsible for the de novo biosynthesis of the DNA building block 2"-deoxy-thymidylate (dTMP). Thymidine Monophosphate 192-196 thymidylate synthetase Homo sapiens 22-27 25581782-4 2015 TSase catalyzes the reductive methylation of 2"-deoxy-uridylate (dUMP) to dTMP using (R)-N(5),N(10)-methylene-5,6,7,8-tetrahydrofolate (MTHF) as a cofactor. Thymidine Monophosphate 74-78 thymidylate synthetase Homo sapiens 0-5 25548164-5 2015 In this study, we examined the impact of MTHFD1 loss of function on folate-dependent purine, dTMP, and methionine biosynthesis in fibroblasts from the proband with MTHFD1 deficiency. Thymidine Monophosphate 93-97 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Homo sapiens 41-47 25245820-2 2015 Thymidylate (dTMP) is catalyzed by thymidylate synthase (TS) using the folate-derived one-carbon unit as the sole methyl donor. Thymidine Monophosphate 13-17 thymidylate synthetase Homo sapiens 35-55 24880094-7 2014 Serum phosphate and TmP/GFR were positively associated with cFGF23 (p<0.01 and p<0.001), iFGF23 (p<0.05 and p<0.001) and Klotho (p<0.05 and p<0.01). Thymidine Monophosphate 20-23 klotho Homo sapiens 133-139 24968719-3 2014 Assessment of 13-day-old Tk2(-/-) mice treated with dCMP+dTMP 200 mg/kg/day each (Tk2(-/-200dCMP/) (dTMP)) demonstrated that in mutant animals, the compounds raise dTTP concentrations, increase levels of mtDNA, ameliorate defects of mitochondrial respiratory chain enzymes, and significantly prolong their lifespan (34 days with treatment versus 13 days untreated). Thymidine Monophosphate 57-61 thymidine kinase 2, mitochondrial Mus musculus 82-85 24718825-8 2014 Moreover, MStMp showed stronger effects on inhibition of ldh leakage, apoptotic cells, intracellular roS level and the expression of caspase-3 and caspase-9 than tMp. Thymidine Monophosphate 12-15 caspase 3 Homo sapiens 133-142 24718825-8 2014 Moreover, MStMp showed stronger effects on inhibition of ldh leakage, apoptotic cells, intracellular roS level and the expression of caspase-3 and caspase-9 than tMp. Thymidine Monophosphate 12-15 caspase 9 Homo sapiens 147-156 24185703-6 2014 In biochemical analyses using human DNA polymerase eta, incorporation of TMP opposite the N-methylcytosine moiety of the CPD was clearly detected, in addition to dGMP incorporation, and the incorrect TMP incorporation blocked DNA synthesis. Thymidine Monophosphate 73-76 DNA polymerase eta Homo sapiens 36-54 24500934-2 2014 Serine hydroxymethyltransferase 1 (SHMT1) regulates thymidylate (dTMP) biosynthesis and uracil accumulation in DNA, and as such affects genome stability. Thymidine Monophosphate 65-69 serine hydroxymethyltransferase 1 (soluble) Mus musculus 0-33 24500934-2 2014 Serine hydroxymethyltransferase 1 (SHMT1) regulates thymidylate (dTMP) biosynthesis and uracil accumulation in DNA, and as such affects genome stability. Thymidine Monophosphate 65-69 serine hydroxymethyltransferase 1 (soluble) Mus musculus 35-40 23831216-7 2013 Compared to animals with solid tumours, the specific STK1 activity (nmol [(3)H]-deoxythymidine monophosphate (dTMP)/min/mg of TK1 protein of 26 kDa) was 30-fold higher in haematological malignancies and 2.5-fold higher in healthy dogs, respectively. Thymidine Monophosphate 110-114 fms related receptor tyrosine kinase 3 Homo sapiens 53-57 23831216-7 2013 Compared to animals with solid tumours, the specific STK1 activity (nmol [(3)H]-deoxythymidine monophosphate (dTMP)/min/mg of TK1 protein of 26 kDa) was 30-fold higher in haematological malignancies and 2.5-fold higher in healthy dogs, respectively. Thymidine Monophosphate 110-114 TK1 Canis lupus familiaris 54-57 23288848-9 2013 In conclusion, the Dm-dNK(+/-)TK2(-/-) mouse model illustrates how dTMP synthesized in the cell nucleus can compensate for loss of intramitochondrial dTMP synthesis in differentiated tissue. Thymidine Monophosphate 67-71 deoxyribonucleoside kinase Drosophila melanogaster 19-25 23351158-1 2013 Thymidine kinase 1 (TK1) provides a crucial precursor, deoxythymidine monophosphate, for nucleic acid synthesis, and the activity of TK1 increases by up to 200-fold during the S-phase of cell division in humans. Thymidine Monophosphate 55-83 thymidine kinase 1 Homo sapiens 0-18 23351158-1 2013 Thymidine kinase 1 (TK1) provides a crucial precursor, deoxythymidine monophosphate, for nucleic acid synthesis, and the activity of TK1 increases by up to 200-fold during the S-phase of cell division in humans. Thymidine Monophosphate 55-83 thymidine kinase 1 Homo sapiens 20-23 23726796-2 2013 In the folate pathway, TYMS catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate [5,10-CH2=THF, derived from tetrahydrofolate (THF)], as a cofactor. Thymidine Monophosphate 75-91 thymidylate synthetase Homo sapiens 23-27 24563811-2 2013 In contrast to the human thymidylate synthase enzyme that utilizes methylene-tetrahydrofolate (CH2H4 folate) for the conversion of dUMP to dTMP, the microbial enzymes utilize an additional non-covalently bound FAD molecule for the hydride transfer from NAD(P)H. Thymidine Monophosphate 139-143 thymidylate synthetase Homo sapiens 25-45 23288848-9 2013 In conclusion, the Dm-dNK(+/-)TK2(-/-) mouse model illustrates how dTMP synthesized in the cell nucleus can compensate for loss of intramitochondrial dTMP synthesis in differentiated tissue. Thymidine Monophosphate 67-71 thymidine kinase 2, mitochondrial Mus musculus 30-33 23288848-9 2013 In conclusion, the Dm-dNK(+/-)TK2(-/-) mouse model illustrates how dTMP synthesized in the cell nucleus can compensate for loss of intramitochondrial dTMP synthesis in differentiated tissue. Thymidine Monophosphate 150-154 deoxyribonucleoside kinase Drosophila melanogaster 19-25 23288848-9 2013 In conclusion, the Dm-dNK(+/-)TK2(-/-) mouse model illustrates how dTMP synthesized in the cell nucleus can compensate for loss of intramitochondrial dTMP synthesis in differentiated tissue. Thymidine Monophosphate 150-154 thymidine kinase 2, mitochondrial Mus musculus 30-33 23385749-2 2013 Thymidylate kinase is an enzyme that catalyses the conversion of dTMP to dTDP using ATP-Mg(2+) as a phosphoryl-donor group. Thymidine Monophosphate 65-69 deoxythymidylate kinase Homo sapiens 0-18 23181752-1 2013 TS (thymidylate synthase) is a key enzyme in the de novo biosynthesis of dTMP, and is indispensable for DNA replication. Thymidine Monophosphate 73-77 thymidylate synthetase Homo sapiens 4-24 24460328-1 2013 Thymidylate synthase (TS) catalyzes the transfer of a methyl group from methylenetetrahydrofolate to dUMP to form dTMP. Thymidine Monophosphate 114-118 thymidylate synthetase Homo sapiens 0-20 23181752-1 2013 TS (thymidylate synthase) is a key enzyme in the de novo biosynthesis of dTMP, and is indispensable for DNA replication. Thymidine Monophosphate 73-77 APC down-regulated 1 Homo sapiens 0-2 23194664-7 2013 Finally, we showed that FQE not only inhibits the phosphatase activity of CpsB, but also ability of PolC(PHP) to catalyse the hydrolysis of pNP-TMP. Thymidine Monophosphate 144-147 phosphohistidine phosphatase 1 Homo sapiens 100-109 24460328-1 2013 Thymidylate synthase (TS) catalyzes the transfer of a methyl group from methylenetetrahydrofolate to dUMP to form dTMP. Thymidine Monophosphate 114-118 APC down-regulated 1 Homo sapiens 22-24 24959535-6 2013 Saturation of beta 2-microglobulin was low (0.34 +- 0.1) and decreased discretely with time (r (2) = 0.15, P < 0.05) and significantly with TMP increases (r (2) = 0.31, P < 0.01). Thymidine Monophosphate 143-146 beta-2-microglobulin Homo sapiens 14-34 23394555-1 2013 Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5"-monophosphate (dTMP) in the presence of ATP and Mg(2+) to form thymidine 5"-diphosphate (dTDP), which is then converted to thymidine 5"-triphosphate (dTTP) by nucleoside-diphosphate kinase (NDK). Thymidine Monophosphate 105-131 deoxythymidylate kinase Homo sapiens 0-18 23394555-1 2013 Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5"-monophosphate (dTMP) in the presence of ATP and Mg(2+) to form thymidine 5"-diphosphate (dTDP), which is then converted to thymidine 5"-triphosphate (dTTP) by nucleoside-diphosphate kinase (NDK). Thymidine Monophosphate 105-131 deoxythymidylate kinase Homo sapiens 20-24 23394555-1 2013 Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5"-monophosphate (dTMP) in the presence of ATP and Mg(2+) to form thymidine 5"-diphosphate (dTDP), which is then converted to thymidine 5"-triphosphate (dTTP) by nucleoside-diphosphate kinase (NDK). Thymidine Monophosphate 105-131 TAR DNA-binding protein-43 homolog Drosophila melanogaster 207-211 23394555-1 2013 Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5"-monophosphate (dTMP) in the presence of ATP and Mg(2+) to form thymidine 5"-diphosphate (dTDP), which is then converted to thymidine 5"-triphosphate (dTTP) by nucleoside-diphosphate kinase (NDK). Thymidine Monophosphate 105-131 cytidine/uridine monophosphate kinase 2 Homo sapiens 277-306 23394555-1 2013 Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5"-monophosphate (dTMP) in the presence of ATP and Mg(2+) to form thymidine 5"-diphosphate (dTDP), which is then converted to thymidine 5"-triphosphate (dTTP) by nucleoside-diphosphate kinase (NDK). Thymidine Monophosphate 105-131 cytidine/uridine monophosphate kinase 2 Homo sapiens 308-311 23394555-1 2013 Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5"-monophosphate (dTMP) in the presence of ATP and Mg(2+) to form thymidine 5"-diphosphate (dTDP), which is then converted to thymidine 5"-triphosphate (dTTP) by nucleoside-diphosphate kinase (NDK). Thymidine Monophosphate 133-137 deoxythymidylate kinase Homo sapiens 0-18 23394555-1 2013 Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5"-monophosphate (dTMP) in the presence of ATP and Mg(2+) to form thymidine 5"-diphosphate (dTDP), which is then converted to thymidine 5"-triphosphate (dTTP) by nucleoside-diphosphate kinase (NDK). Thymidine Monophosphate 133-137 deoxythymidylate kinase Homo sapiens 20-24 23394555-1 2013 Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5"-monophosphate (dTMP) in the presence of ATP and Mg(2+) to form thymidine 5"-diphosphate (dTDP), which is then converted to thymidine 5"-triphosphate (dTTP) by nucleoside-diphosphate kinase (NDK). Thymidine Monophosphate 133-137 TAR DNA-binding protein-43 homolog Drosophila melanogaster 207-211 23394555-1 2013 Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5"-monophosphate (dTMP) in the presence of ATP and Mg(2+) to form thymidine 5"-diphosphate (dTDP), which is then converted to thymidine 5"-triphosphate (dTTP) by nucleoside-diphosphate kinase (NDK). Thymidine Monophosphate 133-137 cytidine/uridine monophosphate kinase 2 Homo sapiens 277-306 23394555-1 2013 Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5"-monophosphate (dTMP) in the presence of ATP and Mg(2+) to form thymidine 5"-diphosphate (dTDP), which is then converted to thymidine 5"-triphosphate (dTTP) by nucleoside-diphosphate kinase (NDK). Thymidine Monophosphate 133-137 cytidine/uridine monophosphate kinase 2 Homo sapiens 308-311 23206863-1 2013 Thymidylate kinase (TMK) is an essential enzyme for DNA synthesis in bacteria, phosphorylating deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), and thus is a potential new antibacterial drug target. Thymidine Monophosphate 95-123 deoxythymidylate kinase Homo sapiens 0-18 23206863-1 2013 Thymidylate kinase (TMK) is an essential enzyme for DNA synthesis in bacteria, phosphorylating deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), and thus is a potential new antibacterial drug target. Thymidine Monophosphate 95-123 deoxythymidylate kinase Homo sapiens 20-23 23206863-1 2013 Thymidylate kinase (TMK) is an essential enzyme for DNA synthesis in bacteria, phosphorylating deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), and thus is a potential new antibacterial drug target. Thymidine Monophosphate 125-129 deoxythymidylate kinase Homo sapiens 0-18 23206863-1 2013 Thymidylate kinase (TMK) is an essential enzyme for DNA synthesis in bacteria, phosphorylating deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), and thus is a potential new antibacterial drug target. Thymidine Monophosphate 125-129 deoxythymidylate kinase Homo sapiens 20-23 23839994-3 2013 The trimethoprim-based chemical tag (TMP-tag) was initially developed based on the high affinity interaction between E. coli dihydrofolate reductase and the antibiotic trimethoprim and was subsequently rendered covalent and fluorogenic via proximity-induced protein labeling reactions. Thymidine Monophosphate 37-40 Dihydrofolate reductase Escherichia coli 125-148 22587784-5 2012 This recombinant protein had TMK activity, this is that dTMP was phosphorylated to dTDP and we found that the dimeric state of the protein was the functional and a theoretical structural model was built as such. Thymidine Monophosphate 56-60 TAR DNA-binding protein-43 homolog Drosophila melanogaster 83-87 22307944-1 2012 Thymidylate synthase (TS) is an important enzyme involved in folate metabolism and catalyzes methylation of deoxyuridine monophosphate to deoxythymidine monophosphate, which is essential for DNA replication. Thymidine Monophosphate 138-166 thymidylate synthetase Homo sapiens 0-20 22307944-1 2012 Thymidylate synthase (TS) is an important enzyme involved in folate metabolism and catalyzes methylation of deoxyuridine monophosphate to deoxythymidine monophosphate, which is essential for DNA replication. Thymidine Monophosphate 138-166 thymidylate synthetase Homo sapiens 22-24 22977231-6 2012 Single nucleotide incorporation experiments indicated that although hpol eta, kappa, and Dpo4 incorporated the correct nucleotide (dTMP) opposite the lesion, dGMP and dAMP were inserted with a comparable frequency. Thymidine Monophosphate 131-135 endothelin receptor type A Homo sapiens 73-76 22377634-4 2012 This prompted a re-examination of commonly used cdc13-ts and stn1-ts mutations, which indicates that these alleles are instead hypomorphic mutations that behave as apparent temperature-sensitive mutations due to the additive effects of the Tmp(-) phenotype. Thymidine Monophosphate 240-243 Stn1p Saccharomyces cerevisiae S288C 61-65 22512654-1 2012 ThyX, a flavin-dependent thymidylate synthase that is involved in the synthesis of dTMP from dUMP, is a promising target for the development of novel antibacterial drugs that aimed at blocking the biosynthesis of dTMP, one of the building blocks of DNA. Thymidine Monophosphate 83-87 FAD-dependent thymidylate synthase Helicobacter pylori 26695 0-4 22512654-1 2012 ThyX, a flavin-dependent thymidylate synthase that is involved in the synthesis of dTMP from dUMP, is a promising target for the development of novel antibacterial drugs that aimed at blocking the biosynthesis of dTMP, one of the building blocks of DNA. Thymidine Monophosphate 213-217 FAD-dependent thymidylate synthase Helicobacter pylori 26695 0-4 22512654-4 2012 Further more, ThyX and ThyA are the only source of dTMP in these organisms and other pathways cannot substitute for their function. Thymidine Monophosphate 51-55 FAD-dependent thymidylate synthase Helicobacter pylori 26695 14-18 22587784-3 2012 Thymidine monophosphate kinase (TMK) is the enzyme that phosphorylates deoxythymidine monophosphate (dTMP) using adenosine triphosphate (ATP) as a phosphate group donor in presence of Mg2+ yielding deoxythymidine diphosphate (dTDP) and adenosine diphosphate. Thymidine Monophosphate 71-99 TAR DNA-binding protein-43 homolog Drosophila melanogaster 226-230 22587784-3 2012 Thymidine monophosphate kinase (TMK) is the enzyme that phosphorylates deoxythymidine monophosphate (dTMP) using adenosine triphosphate (ATP) as a phosphate group donor in presence of Mg2+ yielding deoxythymidine diphosphate (dTDP) and adenosine diphosphate. Thymidine Monophosphate 101-105 TAR DNA-binding protein-43 homolog Drosophila melanogaster 226-230 22761426-2 2012 The enzyme phosphorylates dTMP and dGMP to dTDP and dGDP, respectively, in the presence of a phosphate donor. Thymidine Monophosphate 26-30 TAR DNA-binding protein-43 homolog Drosophila melanogaster 43-47 22377634-6 2012 A return-to-viability experiment following prolonged incubation at 32 , 34 , and 36 with one of these new cdc13-ts alleles argues that the accelerated inviability previously observed at 36 in cdc13-1 rad9-Delta mutant strains is a consequence of the Tmp(-) phenotype. Thymidine Monophosphate 252-255 telomere-binding protein CDC13 Saccharomyces cerevisiae S288C 107-112 22377634-6 2012 A return-to-viability experiment following prolonged incubation at 32 , 34 , and 36 with one of these new cdc13-ts alleles argues that the accelerated inviability previously observed at 36 in cdc13-1 rad9-Delta mutant strains is a consequence of the Tmp(-) phenotype. Thymidine Monophosphate 252-255 telomere-binding protein CDC13 Saccharomyces cerevisiae S288C 194-199 22384047-3 2012 Thymidylate synthase (TYMS) is the solo catalysis enzyme for the de novo synthesis of dTMP, which is the essential precursor of DNA biosynthesis and repair process. Thymidine Monophosphate 86-90 thymidylate synthetase Homo sapiens 0-20 22194612-1 2012 Serine hydroxymethyltransferase 1 (SHMT1) expression limits rates of de novo dTMP synthesis in the nucleus. Thymidine Monophosphate 77-81 serine hydroxymethyltransferase 1 Homo sapiens 0-33 22972349-2 2012 GMP was effective only among GMP, CMP, dTMP, and UMP. Thymidine Monophosphate 39-43 5'-nucleotidase, cytosolic II Homo sapiens 0-3 22004361-8 2012 TMP markedly decreased infarct size and attenuated myocardial apoptosis, as evidenced by a decrease in the apoptotic index and reduced caspase-3 activity. Thymidine Monophosphate 0-3 caspase 3 Rattus norvegicus 135-144 22004361-11 2012 TMP induced phosphorylation of Akt at Ser 473 (1.61 +- 0.18 vs 0.79 +- 0.10 in the IR control group) and phosphorylation of eNOS at Ser1177 (1.87 +- 0.33 vs 0.94 +- 0.22 in the IR control group). Thymidine Monophosphate 0-3 AKT serine/threonine kinase 1 Rattus norvegicus 31-34 22004361-12 2012 Wortmannin abrogated the phosphorylation of Akt and eNOS induced by TMP. Thymidine Monophosphate 68-71 AKT serine/threonine kinase 1 Rattus norvegicus 44-47 22093367-2 2012 This activity is compromised when vitamin B12 concentration is low because methionine synthase activity is reduced, lowering the concentration of S-adenosyl methionine (SAM) which in turn may diminish DNA methylation and cause folate to become unavailable for the conversion of dUMP to dTMP. Thymidine Monophosphate 286-290 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 75-94 22224900-1 2012 Both ThyA and ThyX proteins catalyze the transfer of the methyl group from methylenetetrahydrofolate (CH(2) H(4) -folate) to dUMP, forming dTMP. Thymidine Monophosphate 139-143 FAD-dependent thymidylate synthase Corynebacterium glutamicum ATCC 13032 14-18 22194612-1 2012 Serine hydroxymethyltransferase 1 (SHMT1) expression limits rates of de novo dTMP synthesis in the nucleus. Thymidine Monophosphate 77-81 serine hydroxymethyltransferase 1 Homo sapiens 35-40 22384047-3 2012 Thymidylate synthase (TYMS) is the solo catalysis enzyme for the de novo synthesis of dTMP, which is the essential precursor of DNA biosynthesis and repair process. Thymidine Monophosphate 86-90 thymidylate synthetase Homo sapiens 22-26 21832075-3 2011 Increased DNA replication in proliferating cancerous cells requires TSase activity, which catalyzes the reductive methylation of dUMP to dTMP using (R)-N(5),N(10)-methylene-5,6,7,8-tetrahydrofolate (MTHF) as a cofactor. Thymidine Monophosphate 137-141 thymidylate synthetase Homo sapiens 68-73 22308692-6 2011 Then RT-PCR and Western blot assay were employed to detect the expressions of c-myc, p27, CDK2 and cyclinE1 in HL-60 cells after exposure to TMP. Thymidine Monophosphate 141-144 MYC proto-oncogene, bHLH transcription factor Homo sapiens 78-83 22308692-6 2011 Then RT-PCR and Western blot assay were employed to detect the expressions of c-myc, p27, CDK2 and cyclinE1 in HL-60 cells after exposure to TMP. Thymidine Monophosphate 141-144 interferon alpha inducible protein 27 Homo sapiens 85-88 22308692-6 2011 Then RT-PCR and Western blot assay were employed to detect the expressions of c-myc, p27, CDK2 and cyclinE1 in HL-60 cells after exposure to TMP. Thymidine Monophosphate 141-144 cyclin dependent kinase 2 Homo sapiens 90-94 22308692-6 2011 Then RT-PCR and Western blot assay were employed to detect the expressions of c-myc, p27, CDK2 and cyclinE1 in HL-60 cells after exposure to TMP. Thymidine Monophosphate 141-144 cyclin E1 Homo sapiens 99-107 21878626-3 2011 One such substrate is the pyrimidine biosynthetic enzyme thymidylate synthase (EC 2.1.1.45), which catalyzes the synthesis of TMP and is the sole de novo source of TTP for DNA replication and repair. Thymidine Monophosphate 126-129 thymidylate synthetase Homo sapiens 57-77 21904055-1 2011 The enzyme thymidylate kinase phosphorylates the substrate thymidine 5"-phosphate (dTMP) to form thymidine 5"-diphosphate (dTDP), which is further phosphorylated to dTTP for incorporation into DNA. Thymidine Monophosphate 59-81 TAR DNA-binding protein-43 homolog Drosophila melanogaster 123-127 21904055-1 2011 The enzyme thymidylate kinase phosphorylates the substrate thymidine 5"-phosphate (dTMP) to form thymidine 5"-diphosphate (dTDP), which is further phosphorylated to dTTP for incorporation into DNA. Thymidine Monophosphate 83-87 TAR DNA-binding protein-43 homolog Drosophila melanogaster 123-127 21647531-10 2011 For dUMP methylation, the highest level was observed with 25%, suggesting a low rate of dUMP methylation into dTMP with 25% of MTHFR activity. Thymidine Monophosphate 110-114 methylenetetrahydrofolate reductase Homo sapiens 127-132 21876188-4 2011 Mitochondria purified from wild-type Chinese hamster ovary (CHO) cells and HepG2 cells converted dUMP to dTMP in the presence of NADPH and serine, through the activities of mitochondrial serine hydroxymethyltransferase (SHMT2), thymidylate synthase (TYMS), and a novel human mitochondrial dihydrofolate reductase (DHFR) previously thought to be a pseudogene known as dihydrofolate reductase-like protein 1 (DHFRL1). Thymidine Monophosphate 105-109 serine hydroxymethyltransferase 2 Homo sapiens 173-218 21673071-1 2011 Thymidylate synthase (TS) is the only de novo source of thymidylate (dTMP) for DNA synthesis and repair. Thymidine Monophosphate 69-73 thymidylate synthetase Homo sapiens 0-20 21673071-1 2011 Thymidylate synthase (TS) is the only de novo source of thymidylate (dTMP) for DNA synthesis and repair. Thymidine Monophosphate 69-73 thymidylate synthetase Homo sapiens 22-24 21673071-3 2011 Cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2) contribute to an alternative dTMP-producing pathway, by salvaging thymidine from the tumor milieu, and may modulate resistance to TS-targeting drugs. Thymidine Monophosphate 103-107 thymidine kinase 1 Homo sapiens 28-31 21673071-3 2011 Cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2) contribute to an alternative dTMP-producing pathway, by salvaging thymidine from the tumor milieu, and may modulate resistance to TS-targeting drugs. Thymidine Monophosphate 103-107 thymidine kinase 2 Homo sapiens 69-72 21673071-3 2011 Cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2) contribute to an alternative dTMP-producing pathway, by salvaging thymidine from the tumor milieu, and may modulate resistance to TS-targeting drugs. Thymidine Monophosphate 103-107 thymidylate synthetase Homo sapiens 204-206 21673071-6 2011 Because both TS and TKs contribute to increased cellular dTMP, we hypothesized that TKs mediate resistance to the capacity of TS small interfering RNA (siRNA) to sensitize tumor cells to TS-targeting anticancer drugs. Thymidine Monophosphate 57-61 thymidylate synthetase Homo sapiens 13-15 21188629-1 2011 Thymidylate synthase (TYMS), which catalyzes the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate, is a central enzyme in the folate metabolic pathway. Thymidine Monophosphate 93-121 thymidylate synthetase Homo sapiens 0-20 21188629-1 2011 Thymidylate synthase (TYMS), which catalyzes the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate, is a central enzyme in the folate metabolic pathway. Thymidine Monophosphate 93-121 thymidylate synthetase Homo sapiens 22-26 21491329-1 2011 The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. Thymidine Monophosphate 116-120 thymidine kinase 2 Homo sapiens 25-43 21742238-1 2011 Thymidylate synthase (TS) is an enzyme, which catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5.10-methylenetetrahydrofolate as a cofactor. Thymidine Monophosphate 93-109 thymidylate synthetase Homo sapiens 0-20 21742238-1 2011 Thymidylate synthase (TS) is an enzyme, which catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5.10-methylenetetrahydrofolate as a cofactor. Thymidine Monophosphate 93-109 thymidylate synthetase Homo sapiens 22-24 21371789-2 2011 Together with thymidylate synthase (TS) and dihydrofolate reductase (DHFR), SHMT participates to the thymidylate (dTMP) biosynthetic process. Thymidine Monophosphate 114-118 thymidylate synthetase Homo sapiens 14-34 21371789-2 2011 Together with thymidylate synthase (TS) and dihydrofolate reductase (DHFR), SHMT participates to the thymidylate (dTMP) biosynthetic process. Thymidine Monophosphate 114-118 dihydrofolate reductase Homo sapiens 44-67 21371789-2 2011 Together with thymidylate synthase (TS) and dihydrofolate reductase (DHFR), SHMT participates to the thymidylate (dTMP) biosynthetic process. Thymidine Monophosphate 114-118 dihydrofolate reductase Homo sapiens 69-73 21371789-2 2011 Together with thymidylate synthase (TS) and dihydrofolate reductase (DHFR), SHMT participates to the thymidylate (dTMP) biosynthetic process. Thymidine Monophosphate 114-118 serine hydroxymethyltransferase 1 Homo sapiens 76-80 21495703-1 2011 Epoxidation of olefin by [Ru(TMP)(CO)(O)](-) (TMP = tetramesitylporphine), which is a key step of the photocatalyzed epoxidation of olefin by [Ru(TMP)(CO)], is studied mainly with the density functional theory (DFT) method, where [Ru(Por)(CO)] is employed as a model complex (Por = unsubstituted porphyrin). Thymidine Monophosphate 29-32 cytochrome p450 oxidoreductase Homo sapiens 234-237 21495703-1 2011 Epoxidation of olefin by [Ru(TMP)(CO)(O)](-) (TMP = tetramesitylporphine), which is a key step of the photocatalyzed epoxidation of olefin by [Ru(TMP)(CO)], is studied mainly with the density functional theory (DFT) method, where [Ru(Por)(CO)] is employed as a model complex (Por = unsubstituted porphyrin). Thymidine Monophosphate 29-32 cytochrome p450 oxidoreductase Homo sapiens 276-279 21491329-1 2011 The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. Thymidine Monophosphate 116-120 thymidine kinase 2 Homo sapiens 45-48 21222484-1 2011 5-Fluorouracil (5-FU), 5-fluorodeoxyuridine (5-dUrd), and raltitrixed (RTX) are anticancer agents that target thymidylate synthase (TS), thereby blocking the conversion of dUMP into dTMP. Thymidine Monophosphate 182-186 thymidylate synthetase Homo sapiens 110-130 20726503-8 2010 dCMP and dTMP were most frequently inserted by hPol iota, and only dCMP was inserted by Rev1. Thymidine Monophosphate 9-13 DNA polymerase mu Homo sapiens 47-56 21170873-7 2010 Other studies suggest that the opposite influences on TmP/GFR of growth hormone (stimulation) and estrogen (inhibition) are the determinants of the age-associated changes in TmP/GFR and serum phosphorus. Thymidine Monophosphate 54-57 growth hormone 1 Homo sapiens 65-79 21090681-7 2010 All analogues blocked ~80% of the NPP2-dependent hydrolysis of pnp-TMP, a specific NPP substrate, and inhibited the catabolism of pnp-TMP (K(i) and IC50 both found to be between 10 and 60 muM), Ap5A, and ATP by NPP1. Thymidine Monophosphate 67-70 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 34-38 21090681-7 2010 All analogues blocked ~80% of the NPP2-dependent hydrolysis of pnp-TMP, a specific NPP substrate, and inhibited the catabolism of pnp-TMP (K(i) and IC50 both found to be between 10 and 60 muM), Ap5A, and ATP by NPP1. Thymidine Monophosphate 67-70 latexin Homo sapiens 188-191 21090681-7 2010 All analogues blocked ~80% of the NPP2-dependent hydrolysis of pnp-TMP, a specific NPP substrate, and inhibited the catabolism of pnp-TMP (K(i) and IC50 both found to be between 10 and 60 muM), Ap5A, and ATP by NPP1. Thymidine Monophosphate 67-70 ectonucleotide pyrophosphatase/phosphodiesterase 1 Homo sapiens 211-215 20155847-4 2010 In this scenario, 5,10-methylene-H(4)folate would be more efficiently used for dTMP and DNA synthesis by 677T-MTHFR embryos than wildtype embryos giving the 677T-MTHFR embryos increased viability, and hence increasing mutant T-allele frequency. Thymidine Monophosphate 79-83 methylenetetrahydrofolate reductase Homo sapiens 110-115 20544519-1 2010 Thymidine kinase 1 (TK1) is converting thymidine to thymidine monophosphate, and is related to DNA replication and cell proliferation. Thymidine Monophosphate 52-75 thymidine kinase 1 Homo sapiens 0-18 20651387-1 2010 BACKGROUND: Thymidylate synthase (TS) plays an important role in the conversion of dUMP to dTMP. Thymidine Monophosphate 91-95 thymidylate synthetase Homo sapiens 12-32 20651387-1 2010 BACKGROUND: Thymidylate synthase (TS) plays an important role in the conversion of dUMP to dTMP. Thymidine Monophosphate 91-95 thymidylate synthetase Homo sapiens 34-36 20497505-5 2010 We show that gp1.7 catalyses the phosphorylation of dGMP and dTMP to dGDP and dTDP, respectively, by using either GTP, dGTP or dTTP as the phosphate donor. Thymidine Monophosphate 61-65 TAR DNA-binding protein-43 homolog Drosophila melanogaster 78-82 20544519-1 2010 Thymidine kinase 1 (TK1) is converting thymidine to thymidine monophosphate, and is related to DNA replication and cell proliferation. Thymidine Monophosphate 52-75 thymidine kinase 1 Homo sapiens 20-23 20166743-8 2010 These results indicated that the TMPyP4 delivery and uptake were mediated by the specific interaction of the apt-TMP complex with nucleolin on the cellular surface and that the use of the AS1411 aptamer as a drug carrier may be a potential tactic in cancer therapy. Thymidine Monophosphate 33-36 nucleolin Homo sapiens 130-139 20065942-1 2010 Thymidylate kinase (TMPK) is a nucleoside monophosphate kinase that catalyzes phosphorylation of thymidine monophosphate to thymidine diphosphate. Thymidine Monophosphate 97-120 deoxythymidylate kinase Mus musculus 0-18 20065942-1 2010 Thymidylate kinase (TMPK) is a nucleoside monophosphate kinase that catalyzes phosphorylation of thymidine monophosphate to thymidine diphosphate. Thymidine Monophosphate 97-120 deoxythymidylate kinase Mus musculus 20-24 20725619-1 2010 Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and it is the target for the 5-Fluorouracil (5-FU) activity. Thymidine Monophosphate 59-63 thymidylate synthetase Homo sapiens 0-20 18837522-19 2009 In these respective pathogens, Plasmodium falciparum and Mycobacterium tuberculosis, the biosynthesis of dTMP relies exclusively on dUTPase activity. Thymidine Monophosphate 105-109 Deoxyuridine triphosphatase Drosophila melanogaster 132-139 20005724-9 2010 The most potent analog (5, H2L 7905958) displayed an IC(50) of 1.6microM (K(i)=1.9microM, competitive inhibition) with respect to ATX-mediated FS-3 hydrolysis and an IC(50) of 1.2microM (K(i)=K(i)(")=6.5microM, non-competitive inhibition) against ATX-mediated pNP-TMP hydrolysis. Thymidine Monophosphate 264-267 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 130-133 19228037-6 2009 We have shown that there is an initial rapid quenching of dAP fluorescence followed by a second phase of dAP quenching, which has nearly the same rate as that of dTMP incorporation, as estimated from rapid chemical quench experiments. Thymidine Monophosphate 162-166 dacapo Drosophila melanogaster 105-108 19956884-8 2010 It was also found that the mRNA level of multidrug resistant gene MDR1, MRP2, MRP3 and MRP5 and the level of the proteins they encode were decreased after treatment with TMP, indicating that TMP can effectively reverse the MDR in BEL-7402/ADM cells, and its activity mechanism may be correlated with the down-regulation of expression in these transporters. Thymidine Monophosphate 170-173 ATP binding cassette subfamily B member 1 Homo sapiens 66-70 19956884-8 2010 It was also found that the mRNA level of multidrug resistant gene MDR1, MRP2, MRP3 and MRP5 and the level of the proteins they encode were decreased after treatment with TMP, indicating that TMP can effectively reverse the MDR in BEL-7402/ADM cells, and its activity mechanism may be correlated with the down-regulation of expression in these transporters. Thymidine Monophosphate 170-173 ATP binding cassette subfamily C member 2 Homo sapiens 72-76 19956884-8 2010 It was also found that the mRNA level of multidrug resistant gene MDR1, MRP2, MRP3 and MRP5 and the level of the proteins they encode were decreased after treatment with TMP, indicating that TMP can effectively reverse the MDR in BEL-7402/ADM cells, and its activity mechanism may be correlated with the down-regulation of expression in these transporters. Thymidine Monophosphate 170-173 ATP binding cassette subfamily C member 3 Homo sapiens 78-82 19956884-8 2010 It was also found that the mRNA level of multidrug resistant gene MDR1, MRP2, MRP3 and MRP5 and the level of the proteins they encode were decreased after treatment with TMP, indicating that TMP can effectively reverse the MDR in BEL-7402/ADM cells, and its activity mechanism may be correlated with the down-regulation of expression in these transporters. Thymidine Monophosphate 170-173 ATP binding cassette subfamily C member 5 Homo sapiens 87-91 19956884-8 2010 It was also found that the mRNA level of multidrug resistant gene MDR1, MRP2, MRP3 and MRP5 and the level of the proteins they encode were decreased after treatment with TMP, indicating that TMP can effectively reverse the MDR in BEL-7402/ADM cells, and its activity mechanism may be correlated with the down-regulation of expression in these transporters. Thymidine Monophosphate 191-194 ATP binding cassette subfamily B member 1 Homo sapiens 66-70 19956884-8 2010 It was also found that the mRNA level of multidrug resistant gene MDR1, MRP2, MRP3 and MRP5 and the level of the proteins they encode were decreased after treatment with TMP, indicating that TMP can effectively reverse the MDR in BEL-7402/ADM cells, and its activity mechanism may be correlated with the down-regulation of expression in these transporters. Thymidine Monophosphate 191-194 ATP binding cassette subfamily C member 2 Homo sapiens 72-76 19956884-8 2010 It was also found that the mRNA level of multidrug resistant gene MDR1, MRP2, MRP3 and MRP5 and the level of the proteins they encode were decreased after treatment with TMP, indicating that TMP can effectively reverse the MDR in BEL-7402/ADM cells, and its activity mechanism may be correlated with the down-regulation of expression in these transporters. Thymidine Monophosphate 191-194 ATP binding cassette subfamily C member 3 Homo sapiens 78-82 19956884-8 2010 It was also found that the mRNA level of multidrug resistant gene MDR1, MRP2, MRP3 and MRP5 and the level of the proteins they encode were decreased after treatment with TMP, indicating that TMP can effectively reverse the MDR in BEL-7402/ADM cells, and its activity mechanism may be correlated with the down-regulation of expression in these transporters. Thymidine Monophosphate 191-194 ATP binding cassette subfamily C member 5 Homo sapiens 87-91 19797058-2 2009 One substrate of this pathway is the pyrimidine biosynthetic enzyme thymidylate synthase (TS; EC 2.1.1.45), which catalyzes the reductive methylation of dUMP to form dTMP and is essential for DNA replication during cell growth and proliferation. Thymidine Monophosphate 166-170 thymidylate synthetase Homo sapiens 68-88 19797058-2 2009 One substrate of this pathway is the pyrimidine biosynthetic enzyme thymidylate synthase (TS; EC 2.1.1.45), which catalyzes the reductive methylation of dUMP to form dTMP and is essential for DNA replication during cell growth and proliferation. Thymidine Monophosphate 166-170 thymidylate synthetase Homo sapiens 90-92 19540237-0 2009 The yeast Cdc8 exhibits both deoxythymidine monophosphate and diphosphate kinase activities. Thymidine Monophosphate 29-57 bifunctional thymidylate/uridylate kinase Saccharomyces cerevisiae S288C 10-14 19249312-3 2009 However, TMP-resistant strains have arisen with point mutations in dihydrofolate reductase (DHFR), the target for TMP. Thymidine Monophosphate 9-12 Dihydrofolate reductase Staphylococcus aureus 67-90 19249312-3 2009 However, TMP-resistant strains have arisen with point mutations in dihydrofolate reductase (DHFR), the target for TMP. Thymidine Monophosphate 9-12 Dihydrofolate reductase Staphylococcus aureus 92-96 19249312-3 2009 However, TMP-resistant strains have arisen with point mutations in dihydrofolate reductase (DHFR), the target for TMP. Thymidine Monophosphate 114-117 Dihydrofolate reductase Staphylococcus aureus 67-90 19249312-3 2009 However, TMP-resistant strains have arisen with point mutations in dihydrofolate reductase (DHFR), the target for TMP. Thymidine Monophosphate 114-117 Dihydrofolate reductase Staphylococcus aureus 92-96 19302821-4 2009 Influences of QHYH and one of the active components (tetramethylpyrazine, TMP) on UCP2 expression were subsequently evaluated by quantitative real-time reverse transcription-polymerase chain reaction. Thymidine Monophosphate 74-77 uncoupling protein 2 (mitochondrial, proton carrier) Mus musculus 82-86 18603020-2 2008 Although the precise mechanism for thymineless death has remained elusive, inhibition of the enzyme thymidylate synthase (TS), which catalyzes the de novo synthesis of TMP, has served for many years as a basis for chemotherapeutic strategies. Thymidine Monophosphate 168-171 thymidylate synthetase Homo sapiens 100-120 19087190-1 2009 Thymidine kinase (TK1) is a key enzyme in the salvage pathway of deoxyribonucleotide metabolism, catalyzing the first step in the synthesis of dTTP by transfer of a gamma-phosphate group from a nucleoside triphosphate to the 5"-hydroxyl group of thymidine, forming dTMP. Thymidine Monophosphate 265-269 thymidine kinase 1 Homo sapiens 18-21 19200097-5 2009 Both TBE and TMP could reduce the blood glucose levels of diabetic rats; TBE had stronger abilities to reduce the levels of total cholesterol and total triglyceride in serum, those of malondialdehyde, and enhance the activities of superoxide dismutase and glutathione reductase in different tissues of diabetic rats (P < 0.01). Thymidine Monophosphate 13-16 glutathione-disulfide reductase Rattus norvegicus 256-277 18790647-3 2008 In the present work, we synthesized TBN, a derivative of the clinically useful stroke drug TMP armed with a powerful free radical-scavenging nitrone moiety. Thymidine Monophosphate 91-94 TATA-box binding protein associated factor 8 Rattus norvegicus 36-39 18790647-4 2008 TBN retains the thrombolytic activity of the parent TMP and possesses strong antioxidative properties. Thymidine Monophosphate 52-55 TATA-box binding protein associated factor 8 Rattus norvegicus 0-3 18498354-2 2008 In resting and differentiating cells that withdraw from the cell cycle, mitochondrial thymidine kinase 2 (TK2) mediates thymidine monophosphate (dTMP) formation for the dTTP biosynthesis in mitochondria. Thymidine Monophosphate 120-143 thymidine kinase 2 Homo sapiens 86-104 18616294-13 2008 The incorporation of the correct nucleotide, dAMP, by hpol eta opposite cross-linked T was 3-5-fold more efficient than that of a wrong nucleotide, whereas incorporation of dCMP opposite the cross-linked G was 10-fold more efficient than that with dTMP. Thymidine Monophosphate 248-252 endothelin receptor type A Homo sapiens 59-62 18648921-1 2008 Thymidylate synthase (TS) is essential for de novo synthesis of dTMP and is a key enzyme involved in DNA synthesis and transcriptional regulation of organisms. Thymidine Monophosphate 64-68 thymidylate synthetase Homo sapiens 0-20 21479480-1 2008 Thymidylate synthase, as a rate-limiting step in DNA synthesis, catalyses the conversion of dUMP into dTMP using 5,10-methylenotetrahydrofolate as the methyl donor. Thymidine Monophosphate 102-106 thymidylate synthetase Homo sapiens 0-20 18558517-10 2008 Cleaved caspase-3 protein was decreased significantly in TMP-treated group, while bax, bcl-2 protein expression did not differ statistically among the three groups. Thymidine Monophosphate 57-60 caspase 3 Rattus norvegicus 8-17 18498354-2 2008 In resting and differentiating cells that withdraw from the cell cycle, mitochondrial thymidine kinase 2 (TK2) mediates thymidine monophosphate (dTMP) formation for the dTTP biosynthesis in mitochondria. Thymidine Monophosphate 120-143 thymidine kinase 2 Homo sapiens 106-109 18498354-2 2008 In resting and differentiating cells that withdraw from the cell cycle, mitochondrial thymidine kinase 2 (TK2) mediates thymidine monophosphate (dTMP) formation for the dTTP biosynthesis in mitochondria. Thymidine Monophosphate 145-149 thymidine kinase 2 Homo sapiens 86-104 18498354-2 2008 In resting and differentiating cells that withdraw from the cell cycle, mitochondrial thymidine kinase 2 (TK2) mediates thymidine monophosphate (dTMP) formation for the dTTP biosynthesis in mitochondria. Thymidine Monophosphate 145-149 thymidine kinase 2 Homo sapiens 106-109 18498354-3 2008 However, a thymidine monophosphate kinase (TMPK) that phosphorylates dTMP to form thymidine diphosphate (dTDP) in mitochondria remains undefined. Thymidine Monophosphate 69-73 deoxythymidylate kinase Homo sapiens 11-41 18498354-3 2008 However, a thymidine monophosphate kinase (TMPK) that phosphorylates dTMP to form thymidine diphosphate (dTDP) in mitochondria remains undefined. Thymidine Monophosphate 69-73 deoxythymidylate kinase Homo sapiens 43-47 18498354-3 2008 However, a thymidine monophosphate kinase (TMPK) that phosphorylates dTMP to form thymidine diphosphate (dTDP) in mitochondria remains undefined. Thymidine Monophosphate 69-73 TAR DNA-binding protein-43 homolog Drosophila melanogaster 105-109 18498354-6 2008 Over-expression of TMPK2 increased the steady-state level of cellular dTTP and promoted the conversion of radioactive labeled-thymidine and -dTMP to dTDP and dTTP in mitochondria. Thymidine Monophosphate 141-145 cytidine/uridine monophosphate kinase 2 Homo sapiens 19-24 18720837-2 2008 Thymidylate kinase (TMK) catalyses the phosphorylation of dTMP to dTDP in the de novo and salvage pathways of dTTP synthesis in both prokaryotes and eukaryotes. Thymidine Monophosphate 58-62 TAR DNA-binding protein-43 homolog Drosophila melanogaster 66-70 18321387-10 2008 The absence of dUTPase should reduce cellular dUMP pools and may result in a reduced conversion to dTMP by thymidylate synthetase or an increased reliance on the salvage of thymidine by the viral thymidine kinase. Thymidine Monophosphate 99-103 Deoxyuridine triphosphatase Drosophila melanogaster 15-22 18522277-6 2008 The kinetic parameters of APE1 exonuclease excision of mismatched dCMP and dTMP from the 3" terminus of single-strand DNA and from photoreactive dCMP analogues applied for photoaffinity modification of proteins and DNA in recombinant systems and cell/nuclear extracts were determined. Thymidine Monophosphate 75-79 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 26-30 18056255-1 2008 Dihydrofolate reductase (DHFR) catalyzes folic acid reduction and recycles dihydrofolate generated during dTMP biosynthesis to tetrahydrofolate. Thymidine Monophosphate 106-110 dihydrofolate reductase Danio rerio 0-23 18056255-1 2008 Dihydrofolate reductase (DHFR) catalyzes folic acid reduction and recycles dihydrofolate generated during dTMP biosynthesis to tetrahydrofolate. Thymidine Monophosphate 106-110 dihydrofolate reductase Danio rerio 25-29 17346178-4 2007 DHFR catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate (THF), an essential cofactor in the biosynthesis of thymidylate monophosphate (dTMP). Thymidine Monophosphate 151-155 dihydrofolate reductase Homo sapiens 0-4 18205361-1 2008 Competitive major carbon-carbon bond activation (CCA) and minor carbon-hydrogen bond activation (CHA) channels are identified in the reaction between rhodium(II) meso-tetramesitylporphyrin [Rh(II)(tmp)] (1) and 2,2,6,6-tetramethyl-piperidine-1-oxyl (TEMPO) (2). Thymidine Monophosphate 197-201 Rh blood group D antigen Homo sapiens 190-196 18804702-3 2008 Methylenetetrahydrofolate reductase (MTHFR) is an important folate metabolizing enzyme that catalyzes the irreversible conversion of 5,10-methylenetretrahydrofolate, which is the methyl donor for the conversion of dUMP to dTMP, into 5-methyltetrahydrofolate, which is the methyl donor for remethylation of homocysteine to methionine. Thymidine Monophosphate 222-226 methylenetetrahydrofolate reductase Homo sapiens 0-35 18804702-3 2008 Methylenetetrahydrofolate reductase (MTHFR) is an important folate metabolizing enzyme that catalyzes the irreversible conversion of 5,10-methylenetretrahydrofolate, which is the methyl donor for the conversion of dUMP to dTMP, into 5-methyltetrahydrofolate, which is the methyl donor for remethylation of homocysteine to methionine. Thymidine Monophosphate 222-226 methylenetetrahydrofolate reductase Homo sapiens 37-42 17896913-6 2007 Nonclassical antifolates for antitumor and parasitic chemotherapy, such as nolatrexed (8), trimethoprim {TMP, (11)} and piritrexim {PTX, (12)}, can passively diffuse into cells and hence do not have to depend on FPGS or the reduced folate carrier (RFC). Thymidine Monophosphate 105-108 folylpolyglutamate synthase Homo sapiens 212-216 17696614-8 2007 Finally, our evidence suggests that PLP deficiency threatens genome integrity, most likely via its role in dTMP biosynthesis, as Pdxk-deficient cells accumulate uracil in their nuclear DNA and are sensitive to inhibition of ribonucleotide reductase. Thymidine Monophosphate 107-111 pyridoxal kinase Homo sapiens 129-133 17396263-1 2008 PURPOSE: Thymidylate synthase (TS) is an indispensable enzyme in the de novo biosynthesis of TMP during DNA replication and cell growth, and has, therefore, been an important target for several classes of antimetabolites used in cancer chemotherapy. Thymidine Monophosphate 93-96 thymidylate synthetase Homo sapiens 9-29 17396263-1 2008 PURPOSE: Thymidylate synthase (TS) is an indispensable enzyme in the de novo biosynthesis of TMP during DNA replication and cell growth, and has, therefore, been an important target for several classes of antimetabolites used in cancer chemotherapy. Thymidine Monophosphate 93-96 thymidylate synthetase Homo sapiens 31-33 18589584-1 2008 Thymidylate synthase (TYMS) converts dUMP to dTMP, the rate-limiting nucleotide in DNA synthesis. Thymidine Monophosphate 45-49 thymidylate synthetase Homo sapiens 0-20 18589584-1 2008 Thymidylate synthase (TYMS) converts dUMP to dTMP, the rate-limiting nucleotide in DNA synthesis. Thymidine Monophosphate 45-49 thymidylate synthetase Homo sapiens 22-26 17346178-5 2007 Inhibition of DHFR leads to a deficiency of dTMP since DHF cannot be recycled, and thus causes inhibition of cell growth. Thymidine Monophosphate 44-48 dihydrofolate reductase Homo sapiens 14-18 16259621-1 2006 Thymidylate synthase (TS) catalyses the reductive methylation of dUMP to form dTMP, a reaction that is essential for maintenance of nucleotide pools during cell growth. Thymidine Monophosphate 78-82 thymidylate synthetase Homo sapiens 0-20 16723031-3 2006 Thymidylate synthase (TYMS) is a key enzyme that participates in folate metabolism and catalyzes the conversion of dUMP to dTMP in the process of DNA synthesis. Thymidine Monophosphate 123-127 thymidylate synthetase Homo sapiens 0-20 16723031-3 2006 Thymidylate synthase (TYMS) is a key enzyme that participates in folate metabolism and catalyzes the conversion of dUMP to dTMP in the process of DNA synthesis. Thymidine Monophosphate 123-127 thymidylate synthetase Homo sapiens 22-26 16489621-1 2006 BACKGROUND: Thymidylate synthase (TS) catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) and is a key enzyme for DNA synthesis. Thymidine Monophosphate 104-132 thymidylate synthetase Homo sapiens 12-32 16489621-1 2006 BACKGROUND: Thymidylate synthase (TS) catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) and is a key enzyme for DNA synthesis. Thymidine Monophosphate 104-132 thymidylate synthetase Homo sapiens 34-36 16489621-1 2006 BACKGROUND: Thymidylate synthase (TS) catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) and is a key enzyme for DNA synthesis. Thymidine Monophosphate 134-138 thymidylate synthetase Homo sapiens 12-32 16489621-1 2006 BACKGROUND: Thymidylate synthase (TS) catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) and is a key enzyme for DNA synthesis. Thymidine Monophosphate 134-138 thymidylate synthetase Homo sapiens 34-36 17380903-6 2007 The apyrimidinic sites were formed when DNA fragment containing dTMP and dUMP residues in various ratios was treated with uracil-DNA-glycosylase (UDG). Thymidine Monophosphate 64-68 uracil DNA glycosylase Homo sapiens 122-144 17380903-6 2007 The apyrimidinic sites were formed when DNA fragment containing dTMP and dUMP residues in various ratios was treated with uracil-DNA-glycosylase (UDG). Thymidine Monophosphate 64-68 uracil DNA glycosylase Homo sapiens 146-149 17201138-1 2006 BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation; thymidylate synthase (TS) is a rate-limiting enzyme in the synthesis of dTMP and DNA repair. Thymidine Monophosphate 243-247 methylenetetrahydrofolate reductase Homo sapiens 12-52 17201138-1 2006 BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation; thymidylate synthase (TS) is a rate-limiting enzyme in the synthesis of dTMP and DNA repair. Thymidine Monophosphate 243-247 methylenetetrahydrofolate reductase Homo sapiens 54-59 17201138-1 2006 BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation; thymidylate synthase (TS) is a rate-limiting enzyme in the synthesis of dTMP and DNA repair. Thymidine Monophosphate 243-247 thymidylate synthetase Homo sapiens 171-191 16473525-1 2006 Human cytosolic thymidine kinase (hTK1) is the key enzyme of the pyrimidine salvage pathway and phosphorylates thymidine to thymidine monophosphate, a precursor building block of the DNA. Thymidine Monophosphate 124-147 thymidine kinase 1 Homo sapiens 34-38 16681391-9 2006 Steady-state kinetic studies with pol eta and pol kappa indicated that dTMP, the correct base, was preferentially incorporated opposite the 4-OHEN-dA lesion. Thymidine Monophosphate 71-75 DNA polymerase lambda Homo sapiens 46-55 16685161-1 2006 UNLABELLED: During DNA synthesis in tumors, fluoropyrimidine anticancer agents target thymidylate synthase (TS) that catalyze the synthesis of dTMP from dUMP and are metabolized by dihydropyrimidine dehydrogenase (DPD). Thymidine Monophosphate 143-147 thymidylate synthetase Homo sapiens 86-106 16685161-1 2006 UNLABELLED: During DNA synthesis in tumors, fluoropyrimidine anticancer agents target thymidylate synthase (TS) that catalyze the synthesis of dTMP from dUMP and are metabolized by dihydropyrimidine dehydrogenase (DPD). Thymidine Monophosphate 143-147 dihydropyrimidine dehydrogenase Homo sapiens 181-212 16685161-1 2006 UNLABELLED: During DNA synthesis in tumors, fluoropyrimidine anticancer agents target thymidylate synthase (TS) that catalyze the synthesis of dTMP from dUMP and are metabolized by dihydropyrimidine dehydrogenase (DPD). Thymidine Monophosphate 143-147 dihydropyrimidine dehydrogenase Homo sapiens 214-217 16522804-8 2006 In addition, we observe significant conformational differences in the TMP-binding site in SaTMK as compared to available TMK structures from other bacterial species, Escherichia coli and Mycobacterium tuberculosis as well as human TMK. Thymidine Monophosphate 70-73 AT695_RS00015 Staphylococcus aureus 92-95 16522804-8 2006 In addition, we observe significant conformational differences in the TMP-binding site in SaTMK as compared to available TMK structures from other bacterial species, Escherichia coli and Mycobacterium tuberculosis as well as human TMK. Thymidine Monophosphate 70-73 AT695_RS00015 Staphylococcus aureus 121-124 16259621-1 2006 Thymidylate synthase (TS) catalyses the reductive methylation of dUMP to form dTMP, a reaction that is essential for maintenance of nucleotide pools during cell growth. Thymidine Monophosphate 78-82 thymidylate synthetase Homo sapiens 22-24 16489926-5 2006 We have studied 3 -5 exonuclease activity of APE1 towards dCMP and dTMP residues and modified dCMP analogs with photoreactive groups at the 3 end of the nicked DNA. Thymidine Monophosphate 67-71 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 45-49 16428394-4 2006 The B. hermsii thyX gene complemented the thyA mutation in E. coli, and purified B. hermsii ThyX protein catalyzed the conversion of dTMP from dUMP. Thymidine Monophosphate 133-137 thyX Borrelia hermsii 15-19 16428394-4 2006 The B. hermsii thyX gene complemented the thyA mutation in E. coli, and purified B. hermsii ThyX protein catalyzed the conversion of dTMP from dUMP. Thymidine Monophosphate 133-137 thyX Borrelia hermsii 92-96 16139296-2 2005 This enzyme, ThyX, is a potential antibacterial drug target, since humans and most eukaryotes lack the thyX gene and depend upon the conventional thymidylate synthase (TS) for their dTMP requirements. Thymidine Monophosphate 182-186 thymidylate synthetase Homo sapiens 146-166 16052228-1 2006 Thymidylate synthase (TS) is an essential enzyme that synthesizes thymidylic acid in the de novo biosynthetic pathway. Thymidine Monophosphate 66-81 thymidylate synthetase Homo sapiens 0-20 16052228-1 2006 Thymidylate synthase (TS) is an essential enzyme that synthesizes thymidylic acid in the de novo biosynthetic pathway. Thymidine Monophosphate 66-81 thymidylate synthetase Homo sapiens 22-24 17065087-1 2006 Thymidine kinase (TK1) is a key enzyme in the salvage pathway of nucleotide metabolism and catalyzes the first rate-limiting step in the synthesis of dTTP, transfer of a gamma-phosphate group from a nucleoside triphosphate to the 5"-hydroxyl group of thymidine, thus forming dTMP. Thymidine Monophosphate 275-279 thymidine kinase 1 Homo sapiens 18-21 16276532-1 2006 dTDP-L-rhamnose, an important precursor of O-antigen, was prepared on a large scale from dTMP by executing an one-pot reaction in which six enzymes are involved. Thymidine Monophosphate 89-93 TAR DNA-binding protein-43 homolog Drosophila melanogaster 0-4 16276532-3 2006 The two enzymes were combined with an enzymatic process for dTDP-4-keto-6-deoxy-D-glucose involving TMP kinase, acetate kinase, dTDP-glucose synthase, and dTDP-glucose 4,6-dehydratase, which allowed us to achieve a preparative scale synthesis of dTDP-L-rhamnose using dTMP and glucose-1-phosphate as starting materials. Thymidine Monophosphate 268-272 TAR DNA-binding protein-43 homolog Drosophila melanogaster 60-64 16276532-3 2006 The two enzymes were combined with an enzymatic process for dTDP-4-keto-6-deoxy-D-glucose involving TMP kinase, acetate kinase, dTDP-glucose synthase, and dTDP-glucose 4,6-dehydratase, which allowed us to achieve a preparative scale synthesis of dTDP-L-rhamnose using dTMP and glucose-1-phosphate as starting materials. Thymidine Monophosphate 268-272 TAR DNA-binding protein-43 homolog Drosophila melanogaster 128-132 16276532-3 2006 The two enzymes were combined with an enzymatic process for dTDP-4-keto-6-deoxy-D-glucose involving TMP kinase, acetate kinase, dTDP-glucose synthase, and dTDP-glucose 4,6-dehydratase, which allowed us to achieve a preparative scale synthesis of dTDP-L-rhamnose using dTMP and glucose-1-phosphate as starting materials. Thymidine Monophosphate 268-272 TAR DNA-binding protein-43 homolog Drosophila melanogaster 128-132 16276532-3 2006 The two enzymes were combined with an enzymatic process for dTDP-4-keto-6-deoxy-D-glucose involving TMP kinase, acetate kinase, dTDP-glucose synthase, and dTDP-glucose 4,6-dehydratase, which allowed us to achieve a preparative scale synthesis of dTDP-L-rhamnose using dTMP and glucose-1-phosphate as starting materials. Thymidine Monophosphate 268-272 TAR DNA-binding protein-43 homolog Drosophila melanogaster 128-132 16276532-4 2006 About 82% yield of dTDP-L-rhamnose was obtained based on initial dTMP concentration at 20 mM dTMP, 1 mM ATP, 10 mM NADH, 60 mM acetyl phosphate, and 80 mM glucose-1-phosphate. Thymidine Monophosphate 65-69 TAR DNA-binding protein-43 homolog Drosophila melanogaster 19-23 16276532-4 2006 About 82% yield of dTDP-L-rhamnose was obtained based on initial dTMP concentration at 20 mM dTMP, 1 mM ATP, 10 mM NADH, 60 mM acetyl phosphate, and 80 mM glucose-1-phosphate. Thymidine Monophosphate 93-97 TAR DNA-binding protein-43 homolog Drosophila melanogaster 19-23 16617381-3 2006 Inhibition of TS will result in depletion of both dTMP and, subsequently, dTTP. Thymidine Monophosphate 50-54 thymidylate synthetase Homo sapiens 14-16 16833878-3 2005 According to quantum mechanical calculations, TBP (modeled by trimethyl phosphate TMP) displays stronger hydrogen-bonding interactions with HNO3 than with H2O, and this has been modeled in force-field calculations. Thymidine Monophosphate 82-85 TATA-box binding protein Homo sapiens 46-49 15977277-0 2005 An enzyme module system for the synthesis of dTDP-activated deoxysugars from dTMP and sucrose. Thymidine Monophosphate 77-81 TAR DNA-binding protein-43 homolog Drosophila melanogaster 45-49 15977277-1 2005 A flexible enzyme module system is presented that allows preparative access to important dTDP-activated deoxyhexoses from dTMP and sucrose. Thymidine Monophosphate 122-126 TAR DNA-binding protein-43 homolog Drosophila melanogaster 89-93 15781665-5 2005 MTX inhibits the synthesis of dTMP needed for DNA replication by blocking the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate by MTHFR. Thymidine Monophosphate 30-34 methylenetetrahydrofolate reductase Homo sapiens 154-159 15781665-6 2005 We hypothesized that a deactivating MTHFR allele would increase ALL relapse risk by potentially increasing 5,10-methylenetetrahydrofolate and dTMP, enhancing DNA synthesis and thus opposing MTX. Thymidine Monophosphate 142-146 methylenetetrahydrofolate reductase Homo sapiens 36-41 15533436-6 2004 With pol alpha, eta and kappa, incorrect dTMP was preferentially incorporated opposite the lesion, along with lesser amounts of dCMP, the correct base. Thymidine Monophosphate 41-45 DNA polymerase alpha 1, catalytic subunit Homo sapiens 5-14 15598787-1 2004 Thymidylate synthase (TS), a key one-carbon metabolizing gene, encodes an enzyme that converts dUMP to dTMP, the rate-limiting nucleotide in DNA synthesis. Thymidine Monophosphate 103-107 thymidylate synthetase Homo sapiens 0-20 15598787-1 2004 Thymidylate synthase (TS), a key one-carbon metabolizing gene, encodes an enzyme that converts dUMP to dTMP, the rate-limiting nucleotide in DNA synthesis. Thymidine Monophosphate 103-107 thymidylate synthetase Homo sapiens 22-24 15554708-9 2004 With pol kappa, significant dTMP misincorporation was observed opposite the lesion. Thymidine Monophosphate 28-32 DNA polymerase lambda Homo sapiens 5-14 15339503-6 2004 The expression of VEGF in renal cortex of group TMP and group AG decreased significantly as compared with that of group C, but was still above normal level. Thymidine Monophosphate 48-51 vascular endothelial growth factor A Rattus norvegicus 18-22 15033905-1 2004 Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation and in the production of dTMP for DNA synthesis. Thymidine Monophosphate 178-182 methylenetetrahydrofolate reductase Homo sapiens 0-35 15033905-1 2004 Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation and in the production of dTMP for DNA synthesis. Thymidine Monophosphate 178-182 methylenetetrahydrofolate reductase Homo sapiens 37-42 15218189-1 2004 Thymidylate synthase (TS) (EC 2.1.1.45) is essential for the de novo synthesis of dTMP in prokaryotic and eukaryotic organisms. Thymidine Monophosphate 82-86 thymidylate synthetase Homo sapiens 0-20 15218189-1 2004 Thymidylate synthase (TS) (EC 2.1.1.45) is essential for the de novo synthesis of dTMP in prokaryotic and eukaryotic organisms. Thymidine Monophosphate 82-86 thymidylate synthetase Homo sapiens 22-24 15747312-11 2004 The occurrence of lower intradialytic reductions of Beta2-m with increasing FF% can be interpreted as a consequence of phenomena related to high intradialytic hemoconcentrations, to the excessive increase in the TMP and/or the increase in the protein cake with a consequent reduction in permeability and mass transfer. Thymidine Monophosphate 212-215 beta-2-microglobulin Homo sapiens 52-59 15026078-5 2004 By comparison, the IC(50) of TMP was 12000 nM against Pc, 300 nM against Ma, and 180000 against rat DHFR. Thymidine Monophosphate 29-32 dihydrofolate reductase Rattus norvegicus 100-104 14967037-1 2004 Thymidylate synthase (EC 2.1.1.45) (TS) catalyzes the conversion of dUMP to dTMP and is therefore indispensable for DNA replication in actively dividing cells. Thymidine Monophosphate 76-80 thymidylate synthetase Homo sapiens 0-20 12515520-11 2003 In competitive binding experiments for [(eta(6)-Bip)Ru(en)Cl](+) with 5"-GMP versus 5"-AMP or 5"-CMP or 5"-TMP, the only final adduct was [(eta(6)-Bip)Ru(en)(N7-GMP)]. Thymidine Monophosphate 104-110 heat shock protein family A (Hsp70) member 5 Homo sapiens 48-51 12904564-1 2003 Thymidylate kinase (TMK) catalyses the phosphorylation of dTMP to form dTDP in both the de novo and salvage pathways of dTTP synthesis in both prokaryotes and eukaryotes. Thymidine Monophosphate 58-62 TAR DNA-binding protein-43 homolog Drosophila melanogaster 71-75 12614151-3 2003 To gain further understanding of the determinants for efficient conversion by the enzyme thymidylate kinase (TMPK) of clinically important thymidine monophosphate analogues to the corresponding diphosphates, we solved the crystal structures of the enzyme, with either ADP or the ATP analogue AppNHp at the phosphoryl donor site, in complex with TMP, AZTMP (previous work), NH2TMP, d4TMP, ddTMP, and FLTMP (this work) at the phosphoryl acceptor site. Thymidine Monophosphate 139-162 deoxythymidylate kinase Homo sapiens 109-113 14578129-1 2003 Thymidylate synthase (TS) converts dUMP to dTMP, the rate-limiting nucleotide in DNA synthesis. Thymidine Monophosphate 43-47 thymidylate synthetase Homo sapiens 0-20 14578129-1 2003 Thymidylate synthase (TS) converts dUMP to dTMP, the rate-limiting nucleotide in DNA synthesis. Thymidine Monophosphate 43-47 thymidylate synthetase Homo sapiens 22-24 12684419-3 2003 TS is the key enzyme in the catalysis of the methylation from dUMP to dTMP in the DNA synthetic process. Thymidine Monophosphate 70-74 thymidylate synthetase Homo sapiens 0-2 12161434-7 2002 Stable isotope tracer studies indicate that cSHMT plays an important role in mediating the flux of one-carbon units between dTMP and SAM syntheses. Thymidine Monophosphate 124-128 serine hydroxymethyltransferase 1 Homo sapiens 44-49 12393913-5 2002 Sequential digestions of the covalent complex, substance P analog photoreactive at position 5/NK-1 receptor, with trypsin, endo-GluC and carboxypeptidase Y, led to the identification of the tripeptide (173)TMP(175) in the second extracellular loop of the hNK-1 receptor as the site of photoinsertion. Thymidine Monophosphate 206-209 tachykinin precursor 1 Homo sapiens 47-58 12393913-5 2002 Sequential digestions of the covalent complex, substance P analog photoreactive at position 5/NK-1 receptor, with trypsin, endo-GluC and carboxypeptidase Y, led to the identification of the tripeptide (173)TMP(175) in the second extracellular loop of the hNK-1 receptor as the site of photoinsertion. Thymidine Monophosphate 206-209 tachykinin receptor 1 Homo sapiens 94-107 12393913-5 2002 Sequential digestions of the covalent complex, substance P analog photoreactive at position 5/NK-1 receptor, with trypsin, endo-GluC and carboxypeptidase Y, led to the identification of the tripeptide (173)TMP(175) in the second extracellular loop of the hNK-1 receptor as the site of photoinsertion. Thymidine Monophosphate 206-209 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 128-132 12393913-5 2002 Sequential digestions of the covalent complex, substance P analog photoreactive at position 5/NK-1 receptor, with trypsin, endo-GluC and carboxypeptidase Y, led to the identification of the tripeptide (173)TMP(175) in the second extracellular loop of the hNK-1 receptor as the site of photoinsertion. Thymidine Monophosphate 206-209 tachykinin receptor 1 Homo sapiens 255-269 12466554-6 2002 Interestingly, another human Y-family polymerase, polkappa, was able to extend dTMP inserted opposite a BaP DE dA adduct. Thymidine Monophosphate 79-83 DNA polymerase lambda Homo sapiens 50-58 12161434-9 2002 These results indicate that cSHMT is a metabolic switch that, when activated, gives dTMP synthesis higher metabolic priority than SAM synthesis. Thymidine Monophosphate 84-88 serine hydroxymethyltransferase 1 Homo sapiens 28-33 12239428-3 2002 The aim of this research was to find out the effect of a combined treatment with trioxsalen (TMP)/UVA on NFkappaB binding activity in HaCaT keratinocytes. Thymidine Monophosphate 93-96 nuclear factor kappa B subunit 1 Homo sapiens 105-113 12147691-1 2002 Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and is the target of cancer chemotherapeutic agents (e.g. 5-fluorouracil). Thymidine Monophosphate 59-63 thymidylate synthetase Homo sapiens 0-20 12147691-1 2002 Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and is the target of cancer chemotherapeutic agents (e.g. 5-fluorouracil). Thymidine Monophosphate 59-63 thymidylate synthetase Homo sapiens 22-24 12124385-3 2002 We earlier obtained evidence for a mitochondrial 5"-nucleotidase (dNT2) with a pronounced specificity for dUMP and dTMP and suggested that the enzyme protects mitochondrial DNA replication from excess dTTP. Thymidine Monophosphate 115-119 5',3'-nucleotidase, mitochondrial Homo sapiens 35-64 12124385-3 2002 We earlier obtained evidence for a mitochondrial 5"-nucleotidase (dNT2) with a pronounced specificity for dUMP and dTMP and suggested that the enzyme protects mitochondrial DNA replication from excess dTTP. Thymidine Monophosphate 115-119 spatzle 5 Drosophila melanogaster 66-70 12239428-8 2002 An inhibitory effect on NFkappaB binding activity was found between 30 and 60 min after TMP supplementation of the culture media. Thymidine Monophosphate 88-91 nuclear factor kappa B subunit 1 Homo sapiens 24-32 12239428-9 2002 UVA irradiation induced a 2-fold increase in NFkappaB binding activity in TMP supplemented HaCaT keratinocytes compared with the non-irradiated control. Thymidine Monophosphate 74-77 nuclear factor kappa B subunit 1 Homo sapiens 45-53 12239428-10 2002 In addition, NFkappaB binding activity was higher after UVA irradiation with TMP than in UVA irradiated cells in the absence of TMP. Thymidine Monophosphate 77-80 nuclear factor kappa B subunit 1 Homo sapiens 13-21 12239428-10 2002 In addition, NFkappaB binding activity was higher after UVA irradiation with TMP than in UVA irradiated cells in the absence of TMP. Thymidine Monophosphate 128-131 nuclear factor kappa B subunit 1 Homo sapiens 13-21 12239428-14 2002 Our results indicate that a combined TMP/UVA treatment of HaCaT keratinocytes induces NFkappaB binding activity, and that this is a synergistic effect. Thymidine Monophosphate 37-40 nuclear factor kappa B subunit 1 Homo sapiens 86-94 11950831-6 2002 Further digestion of this fragment with carboxypeptidase Y led to the identification of (173)TMP(175) in the second extracellular loop (E2) of the NK-1 receptor as the site of covalent attachment. Thymidine Monophosphate 93-96 tachykinin receptor 1 Homo sapiens 147-160 12044876-2 2002 We show that purified REV1 protein inserts dCMP opposite template G, A, T and C, and dGMP and dTMP opposite template G in the presence of magnesium, while in the presence of manganese the specificity for dCMP was found to be relaxed and the REV1 protein acquired the ability to insert dCMP, dGMP, dAMP and dTMP opposite templates G, A, T, and C. Kinetic analysis provided evidence for high affinity for dCTP with template G, suggesting that the REV1 protein is specialized for dCTP and template G. Thymidine Monophosphate 94-98 REV1 DNA directed polymerase Homo sapiens 22-26 12044876-2 2002 We show that purified REV1 protein inserts dCMP opposite template G, A, T and C, and dGMP and dTMP opposite template G in the presence of magnesium, while in the presence of manganese the specificity for dCMP was found to be relaxed and the REV1 protein acquired the ability to insert dCMP, dGMP, dAMP and dTMP opposite templates G, A, T, and C. Kinetic analysis provided evidence for high affinity for dCTP with template G, suggesting that the REV1 protein is specialized for dCTP and template G. Thymidine Monophosphate 306-310 REV1 DNA directed polymerase Homo sapiens 22-26 11487279-1 2001 Thymidylate synthase (TS) is an important enzyme catalysing the reductive methylation of dUMP to dTMP that is further metabolized to dTTP for DNA synthesis. Thymidine Monophosphate 97-101 thymidylate synthetase Homo sapiens 0-20 11711549-5 2002 Furthermore, it could be established that the mouse Rev1 protein inserts dGMP and dTMP residues opposite template guanine at a V(max) similar to that for dCMP. Thymidine Monophosphate 82-86 REV1, DNA directed polymerase Mus musculus 52-56 11964185-1 2002 Thymidylate kinase (TMK) catalyses the phosphorylation of dTMP to form dTDP in both the de novo and salvage pathways of dTTP synthesis. Thymidine Monophosphate 58-62 TAR DNA-binding protein-43 homolog Drosophila melanogaster 71-75 11923581-4 2002 TK and TMPK activities were determined by measuring the conversion of [3H] substrates (thymidine or AZT for TK and thymidine monophosphate for TMPK) to their respective monophosphate or diphosphate forms. Thymidine Monophosphate 115-138 deoxythymidylate kinase Homo sapiens 7-11 12374095-2 2001 Therapeutic strategies applied to this pathway target the thymidylate synthase (TS) reaction that catalyzes the reductive methylation of deoxyuridylate (dUMP) to form thymidylate (TMP). Thymidine Monophosphate 180-183 thymidylate synthetase Homo sapiens 58-78 11487279-1 2001 Thymidylate synthase (TS) is an important enzyme catalysing the reductive methylation of dUMP to dTMP that is further metabolized to dTTP for DNA synthesis. Thymidine Monophosphate 97-101 thymidylate synthetase Homo sapiens 22-24 11505394-3 2001 TS is the key enzyme in the catalysis of the methylation from deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate. Thymidine Monophosphate 99-127 thymidylate synthetase Homo sapiens 0-2 11295154-2 2001 This activity is compromised when Vitamin B12 (B12) concentration is low because methionine synthase activity is reduced, lowering the concentration of S-adenosyl methionine (SAM) which in turn may diminish DNA methylation and cause folate to become unavailable for the conversion of dUMP to dTMP. Thymidine Monophosphate 292-296 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 81-100 11384244-4 2001 In general, the nonclassical compounds 7-17 were similar in potency to TMP against Toxoplasma gondii DHFR, with selectivity ratios greater than 38 and 21 for 11 and 16, respectively. Thymidine Monophosphate 71-74 dihydrofolate reductase Homo sapiens 101-105 10585390-3 1999 In particular, insertion of the lid domain of the bacterial TmpK into the human enzyme results in a pronounced change of the acceptance of AZT-MP such that it is now phosphorylated even faster than TMP. Thymidine Monophosphate 198-201 deoxythymidylate kinase Homo sapiens 60-64 11163644-2 2001 Thymidylate synthase (TS) is an essential cellular enzyme that catalyzes de novo synthesis of thymidylic acid (dTMP). Thymidine Monophosphate 94-109 thymidylate synthase Mus musculus 0-20 11163644-2 2001 Thymidylate synthase (TS) is an essential cellular enzyme that catalyzes de novo synthesis of thymidylic acid (dTMP). Thymidine Monophosphate 94-109 thymidylate synthase Mus musculus 22-24 11163644-2 2001 Thymidylate synthase (TS) is an essential cellular enzyme that catalyzes de novo synthesis of thymidylic acid (dTMP). Thymidine Monophosphate 111-115 thymidylate synthase Mus musculus 0-20 11163644-2 2001 Thymidylate synthase (TS) is an essential cellular enzyme that catalyzes de novo synthesis of thymidylic acid (dTMP). Thymidine Monophosphate 111-115 thymidylate synthase Mus musculus 22-24 10873853-1 2000 BACKGROUND: Thymidylate kinase (TMPK) is a nucleoside monophosphate kinase that catalyzes the reversible phosphoryltransfer between ATP and TMP to yield ADP and TDP. Thymidine Monophosphate 32-35 deoxythymidylate kinase Homo sapiens 12-30 10873853-3 2000 RESULTS: Crystal structures of human TMPK in complex with TMP and ADP, TMP and the ATP analog AppNHp, TMP with ADP and the phosphoryl analog AlF(3), TDP and ADP, and the bisubstrate analog TP(5)A were determined. Thymidine Monophosphate 58-61 deoxythymidylate kinase Homo sapiens 37-41 10873853-3 2000 RESULTS: Crystal structures of human TMPK in complex with TMP and ADP, TMP and the ATP analog AppNHp, TMP with ADP and the phosphoryl analog AlF(3), TDP and ADP, and the bisubstrate analog TP(5)A were determined. Thymidine Monophosphate 58-61 deoxythymidylate kinase Homo sapiens 37-41 10799571-3 2000 In the present report, we show that murine CMV (MCMV) infection of quiescent fibroblasts induces both mRNA and protein corresponding to the cellular thymidylate synthase (TS) gene, which encodes the enzyme that catalyzes the de novo synthesis of thymidylic acid. Thymidine Monophosphate 246-261 thymidylate synthetase Homo sapiens 149-169 10714438-4 2000 The TMP was linked to bovine serum albumin (BSA) by carbodiimide reaction, and then modified with the OH. Thymidine Monophosphate 4-7 albumin Oryctolagus cuniculus 29-42 11238980-2 2001 Mutants lacking thymidylate synthase activity (thyA) were isolated and shown to be strictly dependent on thymidine monophosphate precursors in the growth medium. Thymidine Monophosphate 105-128 thymidylate synthase Mus musculus 16-36 11212266-1 2001 Thymidylate synthase catalyzes the reductive methylation of dUMP to dTMP and is essential for the synthesis of DNA. Thymidine Monophosphate 68-72 thymidylate synthetase Homo sapiens 0-20 10775416-4 2000 The met7 mutant becomes petite under normal growth conditions but can be maintained with a grande phenotype if the strain is tup and all media are supplemented with dTMP. Thymidine Monophosphate 165-169 tetrahydrofolate synthase Saccharomyces cerevisiae S288C 4-8 10212232-2 1999 Thymidylate synthase (TS) is indispensable in the de novo synthesis of dTMP. Thymidine Monophosphate 71-75 thymidylate synthetase Homo sapiens 0-20 10536004-1 1999 Reduction of 5,10-methylenetetrahydrofolate (methyleneTHF), a donor for methylating dUMP to dTMP in DNA synthesis, to 5-methyltetrahydrofolate (methylTHF), the primary methyl donor for methionine synthesis, is catalyzed by 5,10-methylenetetrahydrofolate reductase (MTHFR). Thymidine Monophosphate 92-96 methylenetetrahydrofolate reductase Homo sapiens 223-263 10536004-1 1999 Reduction of 5,10-methylenetetrahydrofolate (methyleneTHF), a donor for methylating dUMP to dTMP in DNA synthesis, to 5-methyltetrahydrofolate (methylTHF), the primary methyl donor for methionine synthesis, is catalyzed by 5,10-methylenetetrahydrofolate reductase (MTHFR). Thymidine Monophosphate 92-96 methylenetetrahydrofolate reductase Homo sapiens 265-270 10436407-3 1999 This study determined whether isoproterenol could raise the renal tubular maximum transport of phosphate (TmP) in Hyp mice. Thymidine Monophosphate 106-109 phosphate regulating endopeptidase homolog, X-linked Mus musculus 114-117 10436407-6 1999 As expected, Hyp controls (0.0 dose) had a TmP which was significantly below that of normal controls: 1.15+/-(SEM) 0.6 (n = 9) versus 2.13+/-0.10 (n = 11) micromol P/ml glomerular filtrate (p<0.001). Thymidine Monophosphate 43-46 phosphate regulating endopeptidase homolog, X-linked Mus musculus 13-16 10436407-7 1999 Isoproterenol at doses of 0.5 and 1.0 microg/kg/min elevated the TmP of Hyp mice to the level of normal controls: 1.94+/-0.19 (n = 7) and 1.98+/-0.10 (n = 9) micromol P/ml glomerular filtrate, respectively. Thymidine Monophosphate 65-68 phosphate regulating endopeptidase homolog, X-linked Mus musculus 72-75 10509749-10 1999 The data are consistent with the interpretation that TSs that are highly defective are capable of sufficient dTMP production for cell survival and optimal growth, yet may confer resistance to TS-directed inhibitors. Thymidine Monophosphate 109-113 thymidylate synthetase Homo sapiens 53-55 10212232-2 1999 Thymidylate synthase (TS) is indispensable in the de novo synthesis of dTMP. Thymidine Monophosphate 71-75 thymidylate synthetase Homo sapiens 22-24 9668195-1 1998 Thymidylate synthase (TS), an enzyme that catalyses the conversion of dUMP to dTMP, has been the focus of interest as a target in cancer chemotherapy for more than two decades. Thymidine Monophosphate 78-82 thymidylate synthetase Homo sapiens 0-20 9891493-2 1998 PAP has been isolated independently by several groups in humans, mouse and rabbit, and has received different designations (TMP, EMP-1, CL-20 and B4B). Thymidine Monophosphate 124-127 PDGFA associated protein 1 Homo sapiens 0-3 10051538-2 1999 The host-cell system used was phytohemagglutinin-stimulated peripheral blood mononuclear cells; dTMP and dTTP depletion were induced by single exposures to a low level of the thymidylate synthase inhibitor 5-fluorouracil (5-FU) or its deoxynucleoside, 2"-deoxy-5-fluorouridine. Thymidine Monophosphate 96-100 thymidylate synthetase Homo sapiens 175-195 9748254-1 1998 Thymidylate synthase (TS) catalyzes the methylation of dUMP to dTMP and is the target for the widely used chemotherapeutic agent 5-fluorouracil. Thymidine Monophosphate 63-67 thymidylate synthetase Homo sapiens 0-20 9668195-1 1998 Thymidylate synthase (TS), an enzyme that catalyses the conversion of dUMP to dTMP, has been the focus of interest as a target in cancer chemotherapy for more than two decades. Thymidine Monophosphate 78-82 thymidylate synthetase Homo sapiens 22-24 8621662-7 1996 Thymidine uptake by MTP deltaC-expressing oocytes was inhibited by thymine and dTMP. Thymidine Monophosphate 79-83 microsomal triglyceride transfer protein, gene 1 S homeolog Xenopus laevis 20-23 9701499-2 1998 To estimate the role of 5"-phosphate group ionization in binding of pyrimidine nucleotides by thymidylate synthase, dTMP(S)-F was studied as an inhibitor of mouse tumour (L1210) enzyme, and its inhibitory properties were compared with those of dTMPS2, a close dTMP analogue. Thymidine Monophosphate 116-120 thymidylate synthase Mus musculus 94-114 9255948-0 1997 Sequence-specific 1H, 13C and 15N assignment of the TMP-resistant dihydrofolate reductase mutant DHFR(F98Y) in the ternary complex with TMP and NADPH. Thymidine Monophosphate 52-55 dihydrofolate reductase Homo sapiens 97-101 9255948-0 1997 Sequence-specific 1H, 13C and 15N assignment of the TMP-resistant dihydrofolate reductase mutant DHFR(F98Y) in the ternary complex with TMP and NADPH. Thymidine Monophosphate 136-139 dihydrofolate reductase Homo sapiens 97-101 9179690-8 1997 CONCLUSIONS: The reduction of thymidine kinase caused by treating the mice with IFN-alpha/beta changes the utilization of exogenous thymidine for DNA synthesis, and may represent the mechanism of the additive antitumor effect of the 2 agents, through the suppression of the salvage pathway for deoxythymidine monophosphate induction. Thymidine Monophosphate 294-322 interferon alpha Mus musculus 80-89 8787551-1 1996 ZD1694 (Tomudex; TDX) is a quinazoline antifolate that, when polyglutamated, is a potent inhibitor of thymidylate synthase (TS), the enzyme that converts dUMP to dTMP. Thymidine Monophosphate 162-166 thymidylate synthetase Homo sapiens 102-122 8787551-1 1996 ZD1694 (Tomudex; TDX) is a quinazoline antifolate that, when polyglutamated, is a potent inhibitor of thymidylate synthase (TS), the enzyme that converts dUMP to dTMP. Thymidine Monophosphate 162-166 thymidylate synthetase Homo sapiens 124-126 9636049-2 1998 As measured by Vmax/Km, c-N-I preferred pyrimidine 2"-deoxyribonucleotides as substrates with thymidine monophosphate (TMP) being the most efficient. Thymidine Monophosphate 94-117 5'-nucleotidase, cytosolic IA Homo sapiens 24-29 9636049-2 1998 As measured by Vmax/Km, c-N-I preferred pyrimidine 2"-deoxyribonucleotides as substrates with thymidine monophosphate (TMP) being the most efficient. Thymidine Monophosphate 119-122 5'-nucleotidase, cytosolic IA Homo sapiens 24-29 9926400-1 1998 The thymidylate synthase (TS, EC 2.1.1.45) is essential for the de novo synthesis of dTMP in pro- and eucaryotic organisms. Thymidine Monophosphate 85-89 thymidylate synthetase Homo sapiens 4-24 9374483-2 1997 We have suggested previously that oxidation of LDL"s cholesteryl esters (CE) and phospholipids by soybean (SLO) or human recombinant 15-lipoxygenase (rhLO) can be ascribed largely to alpha-tocopherol (alpha-TOH)-mediated peroxidation (TMP). Thymidine Monophosphate 235-238 arachidonate 15-lipoxygenase Homo sapiens 133-148 9252646-1 1997 BACKGROUND: Thymidylate synthase (dTMP synthase, EC 2.1.1.45) is responsible for the de novo biosynthesis of thymidylate (dTMP) whereas thymidine kinase (TdR kinase, EC 2.7.1.21) is the salvage enzyme which leads to the production of dTMP even in presence of d TMP synthase inhibition. Thymidine Monophosphate 109-120 thymidylate synthetase Homo sapiens 12-32 9252646-1 1997 BACKGROUND: Thymidylate synthase (dTMP synthase, EC 2.1.1.45) is responsible for the de novo biosynthesis of thymidylate (dTMP) whereas thymidine kinase (TdR kinase, EC 2.7.1.21) is the salvage enzyme which leads to the production of dTMP even in presence of d TMP synthase inhibition. Thymidine Monophosphate 34-38 thymidylate synthetase Homo sapiens 12-32 9252646-1 1997 BACKGROUND: Thymidylate synthase (dTMP synthase, EC 2.1.1.45) is responsible for the de novo biosynthesis of thymidylate (dTMP) whereas thymidine kinase (TdR kinase, EC 2.7.1.21) is the salvage enzyme which leads to the production of dTMP even in presence of d TMP synthase inhibition. Thymidine Monophosphate 122-126 thymidylate synthetase Homo sapiens 12-32 8942665-3 1996 Pol alpha catalyzed incorporation of dTMP and dAMP opposite epsilon dC, accompanied by lesser amounts of dCMP and dGMP and some two-base deletions. Thymidine Monophosphate 37-41 DNA polymerase alpha 1, catalytic subunit Homo sapiens 0-9 8910463-6 1996 pol beta preferentially inserts dTMP rather than dCMP opposite m6dG. Thymidine Monophosphate 32-36 DNA polymerase beta Homo sapiens 0-8 8631667-1 1996 Thymidylate kinase (dTMP kinase; EC 2.7.4.9) catalyzes the phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. Thymidine Monophosphate 20-24 TAR DNA-binding protein-43 homolog Drosophila melanogaster 91-95 8628252-2 1996 We have previously shown that depletion of the dTMP pool by aminopterin, an inhibitor of the enzyme dihydrofolate reductase, or by fluorodeoxyuridine, an inhibitor of thymidylate synthetase, induces nicks in the wings of wild-type flies and a strong vg phenotype in vgBG/+ flies and also in individuals heterozygous for a deficiency of the vg locus (vgB/+). Thymidine Monophosphate 47-51 Pyrroline 5-carboyxlate reductase Drosophila melanogaster 114-123 8852837-7 1996 Inactivation of SHM1, SHM2 and ADE3 is required to render yeast auxotrophic for TMP and methionine, suggesting that TMP synthesized in mitochondria may be available to the cytoplasmic compartment. Thymidine Monophosphate 80-83 glycine hydroxymethyltransferase SHM1 Saccharomyces cerevisiae S288C 16-20 8852837-7 1996 Inactivation of SHM1, SHM2 and ADE3 is required to render yeast auxotrophic for TMP and methionine, suggesting that TMP synthesized in mitochondria may be available to the cytoplasmic compartment. Thymidine Monophosphate 80-83 glycine hydroxymethyltransferase SHM2 Saccharomyces cerevisiae S288C 22-26 8852837-7 1996 Inactivation of SHM1, SHM2 and ADE3 is required to render yeast auxotrophic for TMP and methionine, suggesting that TMP synthesized in mitochondria may be available to the cytoplasmic compartment. Thymidine Monophosphate 80-83 trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 Saccharomyces cerevisiae S288C 31-35 8852837-7 1996 Inactivation of SHM1, SHM2 and ADE3 is required to render yeast auxotrophic for TMP and methionine, suggesting that TMP synthesized in mitochondria may be available to the cytoplasmic compartment. Thymidine Monophosphate 116-119 glycine hydroxymethyltransferase SHM1 Saccharomyces cerevisiae S288C 16-20 8852837-7 1996 Inactivation of SHM1, SHM2 and ADE3 is required to render yeast auxotrophic for TMP and methionine, suggesting that TMP synthesized in mitochondria may be available to the cytoplasmic compartment. Thymidine Monophosphate 116-119 glycine hydroxymethyltransferase SHM2 Saccharomyces cerevisiae S288C 22-26 8852837-7 1996 Inactivation of SHM1, SHM2 and ADE3 is required to render yeast auxotrophic for TMP and methionine, suggesting that TMP synthesized in mitochondria may be available to the cytoplasmic compartment. Thymidine Monophosphate 116-119 trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 Saccharomyces cerevisiae S288C 31-35 7647337-1 1995 Thymidylate synthetase (TS) is a key enzyme as a methyl donor in the methylation reaction from dUMP to dTMP. Thymidine Monophosphate 103-107 thymidylate synthetase Homo sapiens 0-22 8845311-1 1995 Thymidylate kinase (TMK) catalyzes an essential reaction of converting dTMP to dTDP, leading to formation of the DNA precursor dTTP. Thymidine Monophosphate 71-75 deoxythymidylate kinase Mus musculus 0-18 8845311-1 1995 Thymidylate kinase (TMK) catalyzes an essential reaction of converting dTMP to dTDP, leading to formation of the DNA precursor dTTP. Thymidine Monophosphate 71-75 deoxythymidylate kinase Mus musculus 20-23 8845311-1 1995 Thymidylate kinase (TMK) catalyzes an essential reaction of converting dTMP to dTDP, leading to formation of the DNA precursor dTTP. Thymidine Monophosphate 71-75 TAR DNA-binding protein-43 homolog Drosophila melanogaster 79-83 7647524-3 1995 After adding the TMP (1 mmol) to the cultures, the IL-6 bioactivity were 2118 +/- 215 that were markedly lower than those in controls (4128 +/- 351, P < 0.01). Thymidine Monophosphate 17-20 interleukin 6 Homo sapiens 51-55 7623777-1 1995 Thymidylate synthase (TS) is a homodimeric enzyme that catalyzes the reductive methylation of dUMP by N5,N10-methylene-5,6,7,8-tetrahydrofolic acid, to form dTMP. Thymidine Monophosphate 157-161 thymidylate synthetase Homo sapiens 0-20 7708490-2 1995 When a primed template with 2-OH-Ade was treated with an exonuclease-deficient Klenow fragment of Escherichia coli DNA polymerase I (KFexo-), recombinant rat DNA polymerase beta (pol beta) or calf thymus DNA polymerase alpha (pol alpha), incorporation of dTMP and dAMP was observed. Thymidine Monophosphate 255-259 DNA polymerase beta Rattus norvegicus 158-177 7708490-4 1995 A steady-state kinetic study indicated that the insertion of dAMP and dTMP opposite the DNA lesion occurred with similar frequency with KFexo- and pol beta. Thymidine Monophosphate 70-74 DNA polymerase beta Rattus norvegicus 147-155 7647524-4 1995 It revealed that the TMP inhibited the growth of MC and the mechanism of its inhibition might be due to that TMP could reduce the IL-6. Thymidine Monophosphate 21-24 interleukin 6 Homo sapiens 130-134 7647524-4 1995 It revealed that the TMP inhibited the growth of MC and the mechanism of its inhibition might be due to that TMP could reduce the IL-6. Thymidine Monophosphate 109-112 interleukin 6 Homo sapiens 130-134 8400344-1 1993 Thymidylate synthase (TS) is responsible for the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate. Thymidine Monophosphate 93-121 thymidylate synthetase Homo sapiens 0-20 8162578-2 1994 In the absence of Mg2+, the presence of Ni2+ ions at concentrations below 0.25 mM gave rise to a dose-dependent activation of pol alpha as monitored by [3H]dTMP incorporation into an activated DNA template. Thymidine Monophosphate 156-160 DNA polymerase alpha 1, catalytic subunit Homo sapiens 126-135 8195830-5 1993 Thus, the TMP binding affinity of E. coli DHFR is increased by NADPH in the ternary complex, and this increased affinity (cooperativity) varies with methoxy group substitution. Thymidine Monophosphate 10-13 Dihydrofolate reductase Escherichia coli 42-46 8195830-7 1993 The difference in the magnitude of NADPH/TMP cooperativity between bacterial and mammalian DHFR is an important factor in selectivity. Thymidine Monophosphate 41-44 dihydrofolate reductase Homo sapiens 91-95 8195830-9 1993 Although the X-ray crystal structures of bacterial and vertebrate DHFR have been studied extensively, no single hypothesis convincingly explains the molecular basis of TMP selectivity. Thymidine Monophosphate 168-171 Dihydrofolate reductase Escherichia coli 66-70 8223452-4 1993 Using gene disruption and tetrad analysis, we find that DUT1 is necessary for the viability of S. cerevisiae; however, under certain conditions dut1 null mutants survive if supplied with exogenous thymidylate (dTMP). Thymidine Monophosphate 210-214 bifunctional dITP/dUTP diphosphatase Saccharomyces cerevisiae S288C 144-148 8223452-6 1993 However, in dut1 ung1 double mutants, starvation for dTMP causes dividing cells to arrest and die in all phases of the cell cycle. Thymidine Monophosphate 53-57 bifunctional dITP/dUTP diphosphatase Saccharomyces cerevisiae S288C 12-16 8223452-6 1993 However, in dut1 ung1 double mutants, starvation for dTMP causes dividing cells to arrest and die in all phases of the cell cycle. Thymidine Monophosphate 53-57 uracil-DNA glycosylase Saccharomyces cerevisiae S288C 17-21 8246876-1 1993 Thymidine kinase (TK) and thymidylate synthetase (TS) are known to catalyse the phosphorylation of thymidine for the salvage synthesis of dTMP and the methylation of dUMP for the de novo synthesis of dTMP, respectively. Thymidine Monophosphate 138-142 thymidylate synthetase Homo sapiens 26-48 8246876-1 1993 Thymidine kinase (TK) and thymidylate synthetase (TS) are known to catalyse the phosphorylation of thymidine for the salvage synthesis of dTMP and the methylation of dUMP for the de novo synthesis of dTMP, respectively. Thymidine Monophosphate 200-204 thymidylate synthetase Homo sapiens 26-48 7574499-1 1995 Thymidylate synthase (TS, EC 2.1.1.45) catalyzes the reductive methylation of dUMP by CH2H4folate to produce dTMP and H2folate. Thymidine Monophosphate 109-113 thymidylate synthetase Homo sapiens 0-20 7574499-1 1995 Thymidylate synthase (TS, EC 2.1.1.45) catalyzes the reductive methylation of dUMP by CH2H4folate to produce dTMP and H2folate. Thymidine Monophosphate 109-113 thymidylate synthetase Homo sapiens 22-24 8841637-4 1995 The Klenow fragment, DNA polymerases alpha and beta incorporated dTMP and other nucleotides opposite 2-OH-Ade in DNA templates in vitro in a sequence-dependent manner. Thymidine Monophosphate 65-69 DNA polymerase alpha 1, catalytic subunit Homo sapiens 21-42 8068016-1 1994 It is known that the Herpes simplex virus type 1 (HSV-1)-encoded thymidine kinase (TK) co-purifies with an associated thymidylate kinase (TMPK) activity and that thymidylate (TMP) inhibits the phosphorylation of thymidine by the HSV-1 TK. Thymidine Monophosphate 138-141 involved in nucleotide metabolism Human alphaherpesvirus 1 65-81 8068016-1 1994 It is known that the Herpes simplex virus type 1 (HSV-1)-encoded thymidine kinase (TK) co-purifies with an associated thymidylate kinase (TMPK) activity and that thymidylate (TMP) inhibits the phosphorylation of thymidine by the HSV-1 TK. Thymidine Monophosphate 138-141 involved in nucleotide metabolism Human alphaherpesvirus 1 83-85 8014187-1 1994 Thymidylate synthase (TS) is an essential enzyme that catalyzes the formation of thymidylic acid in the de novo biosynthetic pathway and is the target enzyme for a variety of chemotherapeutic agents. Thymidine Monophosphate 81-96 thymidylate synthetase Homo sapiens 0-20 8014187-1 1994 Thymidylate synthase (TS) is an essential enzyme that catalyzes the formation of thymidylic acid in the de novo biosynthetic pathway and is the target enzyme for a variety of chemotherapeutic agents. Thymidine Monophosphate 81-96 thymidylate synthetase Homo sapiens 22-24 8400344-1 1993 Thymidylate synthase (TS) is responsible for the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate. Thymidine Monophosphate 93-121 thymidylate synthetase Homo sapiens 22-24 8394402-13 1993 A positive correlation was pointed out in all patients between TMp and t-PA (p = 0.047), TMp and PG12 (p = 0.008). Thymidine Monophosphate 63-66 plasminogen activator, tissue type Homo sapiens 71-75 8349008-8 1993 The presence of dUMP, dTMP, or FdUMP interfered with the binding of PLP to thymidylate synthase, and the presence of equimolar amounts of PLP interfered with the binding of dUMP. Thymidine Monophosphate 22-26 thymidylate synthetase Homo sapiens 75-95 8097706-1 1993 The properties of UDP-glucuronosyltransferase (UDPGT) toward digitoxigenin-monodigitoxoside (DT1) have been studied in human liver microsomes. Thymidine Monophosphate 93-96 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 18-45 8097706-1 1993 The properties of UDP-glucuronosyltransferase (UDPGT) toward digitoxigenin-monodigitoxoside (DT1) have been studied in human liver microsomes. Thymidine Monophosphate 93-96 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 47-52 8394402-14 1993 A positive correlation between TMp and t-PA (p = 0.034) was found only in the subgroup with POAD. Thymidine Monophosphate 31-34 plasminogen activator, tissue type Homo sapiens 39-43 33807173-7 2021 TMP significantly down-regulated KHK, GLO1, ATP5H, SOD, and DDAH1 and up-regulated DLD, Mup1, CPS1, Ces3b, PDI, and HYOU1 compared to the HFD-SP group. Thymidine Monophosphate 0-3 ketohexokinase Mus musculus 33-36 1430788-1 1992 Thymidylate synthetase catalyses the formation of thymidine monophosphate from deoxyuridine monophosphate. Thymidine Monophosphate 50-73 thymidylate synthetase Homo sapiens 0-22 1541269-8 1992 Both dTDP-6-deoxy-D-xylo-4-hexulose and dTDP-L-rhamnose have light absorption maxima at 267 nm, with molar absorption coefficients close to that of dTMP. Thymidine Monophosphate 148-152 TAR DNA-binding protein-43 homolog Drosophila melanogaster 5-9 1541269-8 1992 Both dTDP-6-deoxy-D-xylo-4-hexulose and dTDP-L-rhamnose have light absorption maxima at 267 nm, with molar absorption coefficients close to that of dTMP. Thymidine Monophosphate 148-152 TAR DNA-binding protein-43 homolog Drosophila melanogaster 40-44 1720706-1 1991 Thymidylate synthase (TS; EC 2.1.1.45) is an important cellular enzyme that converts dUMP to dTMP, which is essential for DNA biosynthesis. Thymidine Monophosphate 93-97 thymidylate synthetase Homo sapiens 0-20 1720706-1 1991 Thymidylate synthase (TS; EC 2.1.1.45) is an important cellular enzyme that converts dUMP to dTMP, which is essential for DNA biosynthesis. Thymidine Monophosphate 93-97 thymidylate synthetase Homo sapiens 22-24 2017365-1 1991 (Deoxy)thymidylate (dTMP) kinase is an enzyme which phosphorylates dTMP to dTDP in the presence of ATP and magnesium. Thymidine Monophosphate 20-24 TAR DNA-binding protein-43 homolog Drosophila melanogaster 75-79 33807173-4 2021 TMP alleviated hepatic steatosis (lipid contents and lipid droplets) in high-fat-fed mice and down-regulated the PPARgamma, CD36, and DGAT2 gene levels. Thymidine Monophosphate 0-3 peroxisome proliferator activated receptor gamma Mus musculus 113-122 18407115-5 1992 The observed hypophosphatemia, hypocalcemia, and PTH hypersecretion would represent alterations secondary to a low TmP(i)/GFR and to reduced 1,25(OH)(2)D(3) production. Thymidine Monophosphate 115-118 parathyroid hormone Homo sapiens 49-52 1867645-7 1991 5"-Nucleotidase activities with TMP as substrate were 428.9 +/- 37.8 and 255.9 +/- 28.7 pmol/mg protein/min in H9 and H9-AZT cells, respectively. Thymidine Monophosphate 32-35 5'-nucleotidase ecto Homo sapiens 0-15 33807173-7 2021 TMP significantly down-regulated KHK, GLO1, ATP5H, SOD, and DDAH1 and up-regulated DLD, Mup1, CPS1, Ces3b, PDI, and HYOU1 compared to the HFD-SP group. Thymidine Monophosphate 0-3 glyoxalase 1 Mus musculus 38-42 33807173-7 2021 TMP significantly down-regulated KHK, GLO1, ATP5H, SOD, and DDAH1 and up-regulated DLD, Mup1, CPS1, Ces3b, PDI, and HYOU1 compared to the HFD-SP group. Thymidine Monophosphate 0-3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D Mus musculus 44-49 33807173-7 2021 TMP significantly down-regulated KHK, GLO1, ATP5H, SOD, and DDAH1 and up-regulated DLD, Mup1, CPS1, Ces3b, PDI, and HYOU1 compared to the HFD-SP group. Thymidine Monophosphate 0-3 dimethylarginine dimethylaminohydrolase 1 Mus musculus 60-65 33807173-7 2021 TMP significantly down-regulated KHK, GLO1, ATP5H, SOD, and DDAH1 and up-regulated DLD, Mup1, CPS1, Ces3b, PDI, and HYOU1 compared to the HFD-SP group. Thymidine Monophosphate 0-3 major urinary protein 1 Mus musculus 88-92 33807173-7 2021 TMP significantly down-regulated KHK, GLO1, ATP5H, SOD, and DDAH1 and up-regulated DLD, Mup1, CPS1, Ces3b, PDI, and HYOU1 compared to the HFD-SP group. Thymidine Monophosphate 0-3 carbamoyl-phosphate synthetase 1 Mus musculus 94-98 33807173-7 2021 TMP significantly down-regulated KHK, GLO1, ATP5H, SOD, and DDAH1 and up-regulated DLD, Mup1, CPS1, Ces3b, PDI, and HYOU1 compared to the HFD-SP group. Thymidine Monophosphate 0-3 carboxylesterase 3B Mus musculus 100-105 33807173-7 2021 TMP significantly down-regulated KHK, GLO1, ATP5H, SOD, and DDAH1 and up-regulated DLD, Mup1, CPS1, Ces3b, PDI, and HYOU1 compared to the HFD-SP group. Thymidine Monophosphate 0-3 prolyl 4-hydroxylase, beta polypeptide Mus musculus 107-110 33807173-7 2021 TMP significantly down-regulated KHK, GLO1, ATP5H, SOD, and DDAH1 and up-regulated DLD, Mup1, CPS1, Ces3b, PDI, and HYOU1 compared to the HFD-SP group. Thymidine Monophosphate 0-3 hypoxia up-regulated 1 Mus musculus 116-121 34885361-10 2021 When using additive-free TMP, a low friction coefficient was observed for the cam/tappet interface. Thymidine Monophosphate 25-28 calmodulin 3 Homo sapiens 78-81 9920857-4 1999 Alternatively, a thymidylate synthase inhibition assay (TSIA), based on inhibition of the TS-catalyzed conversion of 3H-dUMP to dTMP and 3H2O, correlated with the MTT assay for antifolate sensitivity in four human leukemia cell lines with different modes of MTX resistance. Thymidine Monophosphate 128-132 thymidylate synthetase Homo sapiens 17-37 34694685-2 2022 Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two being targets of widely used chemotherapeutics such as antifolates and 5-fluorouracil. Thymidine Monophosphate 0-28 serine hydroxymethyltransferase 1 Homo sapiens 92-123 34795209-4 2021 However, nothing else is known, except that DTYMK could catalyze the phosphorylation of deoxythymidine monophosphate (dTMP) to form deoxythymidine diphosphate (dTDP). Thymidine Monophosphate 88-116 deoxythymidylate kinase Homo sapiens 44-49 34795209-4 2021 However, nothing else is known, except that DTYMK could catalyze the phosphorylation of deoxythymidine monophosphate (dTMP) to form deoxythymidine diphosphate (dTDP). Thymidine Monophosphate 88-116 TAR DNA-binding protein-43 homolog Drosophila melanogaster 160-164 34795209-4 2021 However, nothing else is known, except that DTYMK could catalyze the phosphorylation of deoxythymidine monophosphate (dTMP) to form deoxythymidine diphosphate (dTDP). Thymidine Monophosphate 118-122 deoxythymidylate kinase Homo sapiens 44-49 34795209-4 2021 However, nothing else is known, except that DTYMK could catalyze the phosphorylation of deoxythymidine monophosphate (dTMP) to form deoxythymidine diphosphate (dTDP). Thymidine Monophosphate 118-122 TAR DNA-binding protein-43 homolog Drosophila melanogaster 160-164 34778377-2 2021 5-Fu/LV prevents cell proliferation by inhibiting thymidylate synthase, which catalyzes the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate. Thymidine Monophosphate 136-164 thymidylate synthase Mus musculus 50-70 34694685-2 2022 Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two being targets of widely used chemotherapeutics such as antifolates and 5-fluorouracil. Thymidine Monophosphate 0-28 serine hydroxymethyltransferase 1 Homo sapiens 125-129 34694685-2 2022 Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two being targets of widely used chemotherapeutics such as antifolates and 5-fluorouracil. Thymidine Monophosphate 0-28 dihydrofolate reductase Homo sapiens 132-155 34694685-2 2022 Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two being targets of widely used chemotherapeutics such as antifolates and 5-fluorouracil. Thymidine Monophosphate 0-28 dihydrofolate reductase Homo sapiens 157-161 34694685-2 2022 Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two being targets of widely used chemotherapeutics such as antifolates and 5-fluorouracil. Thymidine Monophosphate 0-28 thymidylate synthetase Homo sapiens 167-187 34694685-2 2022 Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two being targets of widely used chemotherapeutics such as antifolates and 5-fluorouracil. Thymidine Monophosphate 0-28 thymidylate synthetase Homo sapiens 189-193 34694685-2 2022 Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two being targets of widely used chemotherapeutics such as antifolates and 5-fluorouracil. Thymidine Monophosphate 30-34 serine hydroxymethyltransferase 1 Homo sapiens 92-123 34694685-2 2022 Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two being targets of widely used chemotherapeutics such as antifolates and 5-fluorouracil. Thymidine Monophosphate 30-34 serine hydroxymethyltransferase 1 Homo sapiens 125-129 34694685-2 2022 Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two being targets of widely used chemotherapeutics such as antifolates and 5-fluorouracil. Thymidine Monophosphate 30-34 dihydrofolate reductase Homo sapiens 132-155 34694685-2 2022 Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two being targets of widely used chemotherapeutics such as antifolates and 5-fluorouracil. Thymidine Monophosphate 30-34 dihydrofolate reductase Homo sapiens 157-161 34694685-2 2022 Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two being targets of widely used chemotherapeutics such as antifolates and 5-fluorouracil. Thymidine Monophosphate 30-34 thymidylate synthetase Homo sapiens 167-187 34694685-2 2022 Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two being targets of widely used chemotherapeutics such as antifolates and 5-fluorouracil. Thymidine Monophosphate 30-34 thymidylate synthetase Homo sapiens 189-193 34694685-6 2022 We have successfully assembled the dTMP synthesis complex in vitro, employing tetrameric SHMT1 and a bifunctional chimeric enzyme comprising human TYMS and DHFR. Thymidine Monophosphate 35-39 serine hydroxymethyltransferase 1 Homo sapiens 89-94 34694685-6 2022 We have successfully assembled the dTMP synthesis complex in vitro, employing tetrameric SHMT1 and a bifunctional chimeric enzyme comprising human TYMS and DHFR. Thymidine Monophosphate 35-39 thymidylate synthetase Homo sapiens 147-151 34694685-6 2022 We have successfully assembled the dTMP synthesis complex in vitro, employing tetrameric SHMT1 and a bifunctional chimeric enzyme comprising human TYMS and DHFR. Thymidine Monophosphate 35-39 dihydrofolate reductase Homo sapiens 156-160 34391120-1 2021 Flavin-Dependent Thymidylate Synthase (FDTS) encoded by ThyX gene was discovered as a new class of thymidylate synthase involved in the de novo synthesis of dTMP named only in 30 % of human pathogenic bacteria. Thymidine Monophosphate 157-161 thymidylate synthetase Homo sapiens 99-119 34646134-11 2021 Our findings indicate that the intracellular levels of dTMP are potential biomarkers for the effective treatment of patients with MPM and suggest the importance of regulatory mechanisms of TYMS expression in the disease. Thymidine Monophosphate 55-59 thymidylate synthetase Homo sapiens 189-193 34157604-2 2021 Thymidylate kinase (TMK/TMPK) is an important enzyme in DNA biosynthesis and catalyses the conversion of dTMP to dTDP. Thymidine Monophosphate 105-109 TAR DNA-binding protein-43 homolog Drosophila melanogaster 113-117 34994281-1 2022 Thymidylate kinase (TMPK) phosphorylates deoxythymidine monophosphate (dTMP) and plays an important role in genome stability. Thymidine Monophosphate 41-69 deoxythymidylate kinase Homo sapiens 0-18 34180142-4 2021 This phenotype is triggered by a disproportionate drop in intracellular dTTP, which could not be explained by drop in dTMP based on the Michaelis-Menten-like in vitro activity curve of thymidylate kinase (Tmk), a downstream enzyme that phosphorylates dTMP to dTDP. Thymidine Monophosphate 251-255 TAR DNA-binding protein-43 homolog Drosophila melanogaster 259-263 35563376-7 2022 SCO2102 localises up-stream of SCO2103, a methylenetetrahydrofolate reductase involved in methionine and dTMP synthesis. Thymidine Monophosphate 105-109 methylenetetrahydrofolate reductase Homo sapiens 42-77 35427566-5 2022 Thymidylate synthase (TYMS), the major target of chemotherapeutic drugs 5-FU or other fluoropyrimidines, which catalyzes the conversion of dUMP to dTMP and provides the sole de novo source of thymidylate for DNA synthesis. Thymidine Monophosphate 147-151 thymidylate synthetase Homo sapiens 0-20 35427566-5 2022 Thymidylate synthase (TYMS), the major target of chemotherapeutic drugs 5-FU or other fluoropyrimidines, which catalyzes the conversion of dUMP to dTMP and provides the sole de novo source of thymidylate for DNA synthesis. Thymidine Monophosphate 147-151 thymidylate synthetase Homo sapiens 22-26 35562546-1 2022 Two plasmid-encoded dihydrofolate reductase (DHFR) isoforms, DfrA1 and DfrA5, that give rise to high levels of resistance in Gram-negative bacteria were structurally and biochemically characterized to reveal the mechanism of TMP resistance and to support phylogenic groupings for drug development against antibiotic resistant pathogens. Thymidine Monophosphate 225-228 Dihydrofolate reductase Escherichia coli 20-43 35562546-1 2022 Two plasmid-encoded dihydrofolate reductase (DHFR) isoforms, DfrA1 and DfrA5, that give rise to high levels of resistance in Gram-negative bacteria were structurally and biochemically characterized to reveal the mechanism of TMP resistance and to support phylogenic groupings for drug development against antibiotic resistant pathogens. Thymidine Monophosphate 225-228 Dihydrofolate reductase Escherichia coli 45-49 35562546-1 2022 Two plasmid-encoded dihydrofolate reductase (DHFR) isoforms, DfrA1 and DfrA5, that give rise to high levels of resistance in Gram-negative bacteria were structurally and biochemically characterized to reveal the mechanism of TMP resistance and to support phylogenic groupings for drug development against antibiotic resistant pathogens. Thymidine Monophosphate 225-228 dihydrofolate reductase Escherichia coli 61-66 34994281-1 2022 Thymidylate kinase (TMPK) phosphorylates deoxythymidine monophosphate (dTMP) and plays an important role in genome stability. Thymidine Monophosphate 41-69 deoxythymidylate kinase Homo sapiens 20-24 34994281-1 2022 Thymidylate kinase (TMPK) phosphorylates deoxythymidine monophosphate (dTMP) and plays an important role in genome stability. Thymidine Monophosphate 71-75 deoxythymidylate kinase Homo sapiens 0-18 34994281-1 2022 Thymidylate kinase (TMPK) phosphorylates deoxythymidine monophosphate (dTMP) and plays an important role in genome stability. Thymidine Monophosphate 71-75 deoxythymidylate kinase Homo sapiens 20-24 2483745-3 1989 2",3"-O-Isopropylidenecytidine 5"-triphosphate inhibits the DNA synthesis catalyzed by reverse transcriptase and DNA polymerase beta and its moiety was incorporated in the place of dTMP residue. Thymidine Monophosphate 181-185 DNA polymerase beta Rattus norvegicus 113-132 2559771-4 1989 Fractionation of serum anti-DNA antibodies into subsets on the basis of their binding to GMP- and TMP-agarose indicated that the resulting GMP- or TMP-reactive antibodies bound to their homologous nucleotides and ssDNA. Thymidine Monophosphate 98-101 5'-nucleotidase, cytosolic II Mus musculus 139-142 2654157-5 1989 This method is sensitive enough to measure dTMP at concentrations as low as 25 pmol, and it was used to show that crude extracts of the human malaria parasite Plasmodium falciparum contain thymidylate synthase but not thymidine kinase activity. Thymidine Monophosphate 43-47 thymidylate synthetase Homo sapiens 189-209 2538159-5 1989 Thymidylate kinase could utilize either ATP or dATP as an efficient phosphate donor, and showed substrate specificity for dTMP. Thymidine Monophosphate 122-126 deoxythymidylate kinase Homo sapiens 0-18 2470808-4 1989 The anatomical relationship between alpha 2uG and TMP-induced protein droplets observed after staining with Lee"s methylene blue-basic fuchsin was studied using serial sections. Thymidine Monophosphate 50-53 alpha2u globulin Rattus norvegicus 36-45 2822457-5 1987 dNase activity occurred with both purine and pyrimidine substrates and was maximal with deoxy analogs (dIMP much greater than dUMP greater than dGMP greater than dTMP = dAMP much greater than dCMP) at a pH optimum of 6.2, but slight cross-reactivity occurred with some nondeoxy substrates (IMP greater than GMP greater than UMP = XMP greater than CMP). Thymidine Monophosphate 162-166 Deoxyribonuclease II Drosophila melanogaster 0-5 3260621-7 1988 Inhibition of thymidylate synthase (dTMP-S) by the two-hour and CI infusion schedules were 66% v 39%, respectively. Thymidine Monophosphate 36-42 thymidylate synthetase Homo sapiens 14-34 2851323-1 1988 Escherichia coli DNA topoisomerase I catalyzes the cleavage of short, single-stranded oligodeoxynucleotides with dT8 as the shortest cleavable oligo(thymidylic acid). Thymidine Monophosphate 149-164 asense Drosophila melanogaster 113-116 3422737-6 1988 Comparative mapping of cleavage sites on a linear pBR322 fragment for tris(phenanthroline)ruthenium(II), which binds to B-DNA and cleaves also by sensitization of singlet oxygen, and for Ru(TMP)2+3 shows the selective binding of lambda-Ru(TMP)2+3 to conformationally distinct sites along the fragment. Thymidine Monophosphate 189-193 translocator protein Homo sapiens 50-53 2894952-2 1988 Glucuronidation of digitoxigenin-monodigitoxoside (DT1), a metabolite of the cardiac glycoside digitoxin, is mediated by the microsomal isozymes, UDP-glucuronosyltransferase(s) (UDP-GT). Thymidine Monophosphate 51-54 beta-1,3-glucuronyltransferase 2 Rattus norvegicus 146-176 2894952-2 1988 Glucuronidation of digitoxigenin-monodigitoxoside (DT1), a metabolite of the cardiac glycoside digitoxin, is mediated by the microsomal isozymes, UDP-glucuronosyltransferase(s) (UDP-GT). Thymidine Monophosphate 51-54 beta-1,3-glucuronyltransferase 2 Rattus norvegicus 178-184 2894952-8 1988 These findings support the hypothesis that PCN and DEX induce a unique form of UDP-GT in the rat that selectively glucuronidates DT1. Thymidine Monophosphate 129-132 beta-1,3-glucuronyltransferase 2 Rattus norvegicus 79-85 3566294-7 1987 Expression of mouse H-2Dd mRNA was not influenced by 5-FU at 10(-5) M up to 6 h. Methotrexate (MTX) has a chemical structure similar to folic acid, and is known to bind to DHFR (dihydrofolate reductase), and inhibit the synthesis of TMP. Thymidine Monophosphate 233-236 dihydrofolate reductase Mus musculus 172-176 3745210-1 1986 The formation of covalent binary complexes of thymidylate synthase and its nucleotide substrate dUMP, product dTMP, and inhibitor, 5-fluorodeoxyuridylate (FdUMP) was investigated using the trichloroacetic acid precipitation method. Thymidine Monophosphate 110-114 thymidylate synthetase Homo sapiens 46-66 3551963-4 1987 Both dTMP and dTTP were shown to be the minimal primers of DNA polymerase alpha, the affinity and V increasing 1.8- and 1.4-fold respectively upon lengthening the primer by each unit from dTMP to d(Tp)9T. Thymidine Monophosphate 5-9 DNA polymerase alpha 1, catalytic subunit Homo sapiens 59-79 3107544-3 1987 The inhibition of de novo pyrimidine synthesis prevents the production of deoxyuridine-5-phosphate, the substrate for the synthesis of thymidine-5-phosphate via thymidylate synthase, whereas the inhibition of the choline shunt prevents the production of HCHO groups and glycine, both of which are involved in the synthesis of 5,10-methylenetetrahydrofolate, which is a cofactor of thymidylate synthase. Thymidine Monophosphate 135-156 Thymidylate synthase Drosophila melanogaster 161-181 3107544-3 1987 The inhibition of de novo pyrimidine synthesis prevents the production of deoxyuridine-5-phosphate, the substrate for the synthesis of thymidine-5-phosphate via thymidylate synthase, whereas the inhibition of the choline shunt prevents the production of HCHO groups and glycine, both of which are involved in the synthesis of 5,10-methylenetetrahydrofolate, which is a cofactor of thymidylate synthase. Thymidine Monophosphate 135-156 Thymidylate synthase Drosophila melanogaster 381-401 3314400-2 1987 The x-ray crystallographic structure of the E. coli DHFR binary TMP complex compared with the ternary enzyme-NADPH-TMP complex suggests without too imaginative extrapolation, that the conformational changes resulting from the binding of one ligand aid in favorably positioning potential binding sites for the second ligand. Thymidine Monophosphate 64-67 dihydrofolate reductase Escherichia coli 52-56 3551963-4 1987 Both dTMP and dTTP were shown to be the minimal primers of DNA polymerase alpha, the affinity and V increasing 1.8- and 1.4-fold respectively upon lengthening the primer by each unit from dTMP to d(Tp)9T. Thymidine Monophosphate 188-192 DNA polymerase alpha 1, catalytic subunit Homo sapiens 59-79 3715918-6 1986 Isoelectrophoresis of serum samples showed that OOS-TMP increased the activities of isozymes LDH 1 and LDH 2. Thymidine Monophosphate 52-55 lactate dehydrogenase A Rattus norvegicus 93-98 3715918-6 1986 Isoelectrophoresis of serum samples showed that OOS-TMP increased the activities of isozymes LDH 1 and LDH 2. Thymidine Monophosphate 52-55 lactate dehydrogenase B Rattus norvegicus 103-108 2937302-3 1986 FUdR inhibits the activity of thymidylate synthase (TS), thereby depleting cells of TMP. Thymidine Monophosphate 84-87 thymidylate synthetase Homo sapiens 30-50 3709927-6 1986 Activation energy for the reaction, catalyzed by thymidylate synthase from mouse tumour but not from mouse thymus, lowers at temperatures above 34 degrees C, reflecting a change of rate-limiting step in dTMP formation. Thymidine Monophosphate 203-207 thymidylate synthase Mus musculus 49-69 3888182-3 1985 Mutant yield in the forward mutation system CAN1----can1 after dTMP excess is comparable to that found after irradiation with UV254nm. Thymidine Monophosphate 63-67 arginine permease CAN1 Saccharomyces cerevisiae S288C 44-48 2985709-6 1985 Radiolabeled dihydrofolate reductase (DHFR) probes identified the type II DHFR as the determinant of TMP resistance. Thymidine Monophosphate 101-104 Dihydrofolate reductase Escherichia coli 13-36 2985709-6 1985 Radiolabeled dihydrofolate reductase (DHFR) probes identified the type II DHFR as the determinant of TMP resistance. Thymidine Monophosphate 101-104 Dihydrofolate reductase Escherichia coli 38-42 2985709-6 1985 Radiolabeled dihydrofolate reductase (DHFR) probes identified the type II DHFR as the determinant of TMP resistance. Thymidine Monophosphate 101-104 Dihydrofolate reductase Escherichia coli 74-78 2985709-7 1985 In contrast with reports from Europe, TMP resistance in multiple species of Enterobacteriaceae was found to be spread in one hospital by a single, stable conjugative plasmid that has a wide host range and encodes the type II DHFR gene. Thymidine Monophosphate 38-41 Dihydrofolate reductase Escherichia coli 225-229 3003658-2 1985 DNA synthesis also occurs if dTTP is replaced by dT or dTMP, indicating activity of enzymes such as thymidine kinase, thymidylate kinase, deoxyribonucleoside-diphosphate kinase and ADN polymerase. Thymidine Monophosphate 55-59 deoxythymidylate kinase Homo sapiens 118-136 3888182-3 1985 Mutant yield in the forward mutation system CAN1----can1 after dTMP excess is comparable to that found after irradiation with UV254nm. Thymidine Monophosphate 63-67 arginine permease CAN1 Saccharomyces cerevisiae S288C 52-56 6396509-5 1984 This mRNA peak coincided with the time during the cell cycle when thymidylate synthase levels were increasing maximally and immediately preceded the peak of DNA synthesis, for which the enzyme provides precursor dTMP. Thymidine Monophosphate 212-216 thymidylate synthase Saccharomyces cerevisiae S288C 66-86 2995273-3 1985 The dTK of the mutant MMdUr-20 (dTK+) appeared to phosphorylate dTMP less well than that of the WT virus, while its affinity for deoxythymidine was not altered. Thymidine Monophosphate 64-68 Tachykinin Drosophila melanogaster 4-7 2995273-3 1985 The dTK of the mutant MMdUr-20 (dTK+) appeared to phosphorylate dTMP less well than that of the WT virus, while its affinity for deoxythymidine was not altered. Thymidine Monophosphate 64-68 Tachykinin Drosophila melanogaster 32-35 3158797-3 1985 We have shown that two inhibitors of thymidylate (dTMP) synthesis - aminopterin inhibiting dihydrofolate reductase (DHFR) and fluorodeoxyuridine (FUdR) inhibiting thymidylate synthetase - result in a significant increase in meiotic recombination in the yellow/white region on the X chromosome of Drosophila melanogaster. Thymidine Monophosphate 50-54 Dihydrofolate reductase Drosophila melanogaster 91-114 3158797-3 1985 We have shown that two inhibitors of thymidylate (dTMP) synthesis - aminopterin inhibiting dihydrofolate reductase (DHFR) and fluorodeoxyuridine (FUdR) inhibiting thymidylate synthetase - result in a significant increase in meiotic recombination in the yellow/white region on the X chromosome of Drosophila melanogaster. Thymidine Monophosphate 50-54 Dihydrofolate reductase Drosophila melanogaster 116-120 6314724-6 1983 TMP/GFR was reduced in both primary hyperparathyroidism (0.53 +/- 0.12 mmol/l GF, mean +/- SEM) and FHH (0.86 +/- 0.14 mmol/l GF). Thymidine Monophosphate 0-3 calcium sensing receptor Homo sapiens 100-103 6373725-8 1984 The auxotrophic requirement of dcd1 dmp1 tup7 strains also can be satisfied by exogenous dTMP but not deoxyuridine. Thymidine Monophosphate 89-93 deoxycytidine monophosphate deaminase Saccharomyces cerevisiae S288C 31-40 6710063-5 1984 The TmP fell by 36% on exogenous PTH stimulation (N = 30.25 +/- 6.7), and by 7.9% 120 min. Thymidine Monophosphate 4-7 parathyroid hormone Homo sapiens 33-36 6287238-2 1982 Retransformation of the dTMP auxotroph GY712 and a temperature-sensitive mutant (cdc21) with purified plasmid (pTL1) yielded Tmp+ transformants at high frequency. Thymidine Monophosphate 24-28 protein-transporting protein SEC63 Saccharomyces cerevisiae S288C 111-115 6350110-5 1983 However, the mutagenic efficiency in ADE1, ADE2 genes per 32P decay is approximately 3 times greater for 32PdGMP than for 32P-TMP. Thymidine Monophosphate 126-129 phosphoribosylaminoimidazolesuccinocarboxamide synthase Saccharomyces cerevisiae S288C 37-41 6350110-5 1983 However, the mutagenic efficiency in ADE1, ADE2 genes per 32P decay is approximately 3 times greater for 32PdGMP than for 32P-TMP. Thymidine Monophosphate 126-129 phosphoribosylaminoimidazole carboxylase ADE2 Saccharomyces cerevisiae S288C 43-47 6356128-5 1983 Because synthesis in vitro represents propagation of replication forks active in vivo at the time of permeabilization, our finding that cdc2 and cdc16 mutants can incorporate dTMP into DNA in such permeabilized cells at 23 degrees C but not at 37 degrees C supports the conclusion that these two mutations directly affect DNA synthesis at replication forks. Thymidine Monophosphate 175-179 anaphase promoting complex subunit CDC16 Saccharomyces cerevisiae S288C 145-150 6304349-11 1983 These findings suggest that a mutation in the dTK polypeptide has affected recognition not only of nucleoside substrates but of the nucleotide substrate dTMP as well, which agrees with the suggestion of Chen et al. Thymidine Monophosphate 153-157 Tachykinin Drosophila melanogaster 46-49 6293915-1 1982 Yeast mutants permeable to dTMP (tup) were selected and two new complementation groups (tup5 and tup7) were identified. Thymidine Monophosphate 27-31 Pho80p Saccharomyces cerevisiae S288C 97-101 6749802-2 1982 The tup7 mutation allowed dramatically greater accumulation of dTMP than any of the other mutations tested. Thymidine Monophosphate 63-67 Pho80p Saccharomyces cerevisiae S288C 4-8 6749802-4 1982 The extracellular dTMP was not appreciably degraded, and that accumulated intracellularly was readily phosphorylated to dTDP and dTTP. Thymidine Monophosphate 18-22 TAR DNA-binding protein-43 homolog Drosophila melanogaster 120-124 6749802-7 1982 The tup7 mutation increased permeability to dTMP (and some other 5"-mononucleotides), but did not affect uptake of nucleosides and purine and pyrimidine bases. Thymidine Monophosphate 44-48 Pho80p Saccharomyces cerevisiae S288C 4-8 6749802-9 1982 These findings and other observations suggest that entry of dTMP in strains carrying the tup7 mutation is mediated by a permease whose function in normal cells is the transport of Pi. Thymidine Monophosphate 60-64 Pho80p Saccharomyces cerevisiae S288C 89-93 6287238-2 1982 Retransformation of the dTMP auxotroph GY712 and a temperature-sensitive mutant (cdc21) with purified plasmid (pTL1) yielded Tmp+ transformants at high frequency. Thymidine Monophosphate 125-128 thymidylate synthase Saccharomyces cerevisiae S288C 81-86 7050673-1 1982 The Saccharomyces cerevisiae tmp3 mutant is deficient in the mitochondrial enzyme complex that participates in the formation of one-carbon-group-tetrahydrofolate coenzymes, serine transhydroxymethylase, dihydrofolate reductase, and thymidylate synthetase, thus leading to multiple nutritional requirements of dTMP, adenine, histidine, and methionine. Thymidine Monophosphate 309-313 glycine hydroxymethyltransferase SHM1 Saccharomyces cerevisiae S288C 29-33 6287238-2 1982 Retransformation of the dTMP auxotroph GY712 and a temperature-sensitive mutant (cdc21) with purified plasmid (pTL1) yielded Tmp+ transformants at high frequency. Thymidine Monophosphate 125-128 protein-transporting protein SEC63 Saccharomyces cerevisiae S288C 111-115 6287238-7 1982 In protein extracts from the thymidylate auxotroph (tmp1-6) enzymatic conversion of dUMP to dTMP was barely detectable. Thymidine Monophosphate 92-96 thymidylate synthase Saccharomyces cerevisiae S288C 52-56 6805512-4 1982 This suggests an inhibitory effect of hydroxyurea on the thymidylate synthase which was proved in experiments in which the conversion of deoxyuridine monophosphate into deoxythymidine monophosphate catalysed by a crude enzyme preparation from P815 cells was inhibited in the presence of hydroxyurea. Thymidine Monophosphate 169-197 thymidylate synthase Mus musculus 57-77 6254831-4 1980 The cyc9 mutant was shown to be allelic with the tup1 mutant and to share its properties, which include the ability to utilize exogenous dTMP, a characteristic flocculent morphology, the lack of sporulation of homozygous diploids and low frequency of mating and abnormally shaped cells of alpha strains. Thymidine Monophosphate 137-141 chromatin-silencing transcriptional regulator TUP1 Saccharomyces cerevisiae S288C 4-8 6449701-1 1980 The biosynthesis of thymine nucleotides in Saccharomyces cerevisiae can be inhibited either by genetic lesions in the structural gene for thymidylate synthetase (TMP1) or by drugs that prevent the methylation of dUMP to dTMP. Thymidine Monophosphate 220-224 thymidylate synthase Saccharomyces cerevisiae S288C 162-166 6153975-0 1980 A distinctive activity of 5"-nucleotidase for dTMP in rat liver mitochondria. Thymidine Monophosphate 46-50 5' nucleotidase, ecto Rattus norvegicus 26-41 72066-0 1977 Changes in enzyme activities of thymidine kinase and 5"-nucleotidase for dTMP during hormonal regeneration of seminal vesicles of mice. Thymidine Monophosphate 73-77 5' nucleotidase, ecto Mus musculus 53-68 334734-2 1977 Spontaneous non-conditional mutants auxotrophic for thymidine 5"-monophosphate (tmp1) lacked detectable thymidylate synthetase activity in cell-free extracts. Thymidine Monophosphate 52-78 thymidylate synthase Saccharomyces cerevisiae S288C 80-84 334734-7 1977 Cells of a temperature-sensitive thymidine 5"-monophosphate auxotroph arrested with a morphology identical to the cdc21 strain at the nonpermissive temperature and contained demonstrably thermolabile thymidylate synthetase activity. Thymidine Monophosphate 33-59 thymidylate synthase Saccharomyces cerevisiae S288C 114-119 72066-1 1977 An increase of thymidine kinase [EC 2.7.1.21] activity and decrease of 5"-nucleotidase [EC 3.1.3.5] activity for dTMP were found during hormonal regeneration of the seminal vesicles by daily or single administration of testosterone propionate into mice castrated 2 weeks previously. Thymidine Monophosphate 113-117 5' nucleotidase, ecto Mus musculus 71-86 899923-1 1977 The relation between the renal handling of phosphate and the serum concentration of immunoreactive parathyroid hormone (i-PTH) was investigated in 15 patients with a very wide range of i-PTH, glomerular filtration rate (GFR), maximal tubular reabsorption of phosphate (TmP) and TmP/GFR-ratio. Thymidine Monophosphate 269-272 parathyroid hormone Homo sapiens 99-118 899923-1 1977 The relation between the renal handling of phosphate and the serum concentration of immunoreactive parathyroid hormone (i-PTH) was investigated in 15 patients with a very wide range of i-PTH, glomerular filtration rate (GFR), maximal tubular reabsorption of phosphate (TmP) and TmP/GFR-ratio. Thymidine Monophosphate 278-281 parathyroid hormone Homo sapiens 99-118 899923-5 1977 An inverse significant correlation was demonstrated between TmP/GFR and i-PTH (p less than 0.001), while none of the other investigated factors correlated thyroid hormone has a key role in the regulation of the tubular handling of phosphate in patients with impaired renal function. Thymidine Monophosphate 60-63 parathyroid hormone Homo sapiens 74-77 990190-6 1976 This finding is unexpected in view of the generally accepted indirect role of vitamine B12 in the methylation of deoxyuridine monophosphate to deoxythymidine monophosphate. Thymidine Monophosphate 143-171 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 87-90 975096-9 1976 On the other hand, intercalation of adriamycin to homodeoxypolynucleotide duplex poly(dA)-poly(dT) and poly(dG)-poly(dC) enhanced the DNase I hydrolysis. Thymidine Monophosphate 95-97 deoxyribonuclease 1 Bos taurus 134-141 1104597-4 1975 It is suggested that the conversion of thymine to thymidine is rate-limiting, while the conversions of thymidine to dTMP, and of dTMP to dTDP are more rapid than other steps in the salvage pathway of thymidine nucleotide. Thymidine Monophosphate 129-133 TAR DNA-binding protein-43 homolog Drosophila melanogaster 137-141 794696-1 1976 Genetic tests with the yeast cell-cycle mutant cdc21 isolated by Hartwell indicate that the CDC21 gene in yeast is the same as the TMP1 gene, whose mutant alleles confer an auxotrophic requirement for thymidine-5"-monophosphate (dTMP). Thymidine Monophosphate 201-227 thymidylate synthase Saccharomyces cerevisiae S288C 47-52 794696-1 1976 Genetic tests with the yeast cell-cycle mutant cdc21 isolated by Hartwell indicate that the CDC21 gene in yeast is the same as the TMP1 gene, whose mutant alleles confer an auxotrophic requirement for thymidine-5"-monophosphate (dTMP). Thymidine Monophosphate 201-227 thymidylate synthase Saccharomyces cerevisiae S288C 92-97 794696-1 1976 Genetic tests with the yeast cell-cycle mutant cdc21 isolated by Hartwell indicate that the CDC21 gene in yeast is the same as the TMP1 gene, whose mutant alleles confer an auxotrophic requirement for thymidine-5"-monophosphate (dTMP). Thymidine Monophosphate 201-227 thymidylate synthase Saccharomyces cerevisiae S288C 131-135 794696-1 1976 Genetic tests with the yeast cell-cycle mutant cdc21 isolated by Hartwell indicate that the CDC21 gene in yeast is the same as the TMP1 gene, whose mutant alleles confer an auxotrophic requirement for thymidine-5"-monophosphate (dTMP). Thymidine Monophosphate 229-233 thymidylate synthase Saccharomyces cerevisiae S288C 92-97 794696-1 1976 Genetic tests with the yeast cell-cycle mutant cdc21 isolated by Hartwell indicate that the CDC21 gene in yeast is the same as the TMP1 gene, whose mutant alleles confer an auxotrophic requirement for thymidine-5"-monophosphate (dTMP). Thymidine Monophosphate 229-233 thymidylate synthase Saccharomyces cerevisiae S288C 131-135 794696-2 1976 Yeast strains carrying cdc21 can grow at 37 degrees in the presence of dTMP provided that they are premeable to this compound. Thymidine Monophosphate 71-75 thymidylate synthase Saccharomyces cerevisiae S288C 23-28 5745507-3 1968 One catalyzes the dAT (copolymer of deoxyadenylate and deoxythymidylate)-primed conversion of adenosine triphosphate and uridine triphosphate into an acid-insoluble product. Thymidine Monophosphate 55-71 Dopamine transporter Drosophila melanogaster 18-21 5002284-1 1971 DNA isolated from Drosophila melanogaster embryos contains measurable amounts of dAT, the copolymer of deoxyadenylate and deoxythymidylate. Thymidine Monophosphate 122-138 Dopamine transporter Drosophila melanogaster 81-84 33716060-11 2021 Furthermore, TMP intervention participated in the inhibition of NLRP3 inflammasome accompanied with pyroptosis, as well as upregulating Trx expression and downregulating p-NF-kappaB, while the protective effect of TMP was limited to the involvement of Txnip overexpression. Thymidine Monophosphate 13-16 NLR family, pyrin domain containing 3 Mus musculus 64-69 33716060-11 2021 Furthermore, TMP intervention participated in the inhibition of NLRP3 inflammasome accompanied with pyroptosis, as well as upregulating Trx expression and downregulating p-NF-kappaB, while the protective effect of TMP was limited to the involvement of Txnip overexpression. Thymidine Monophosphate 13-16 thioredoxin 1 Mus musculus 136-139 33716060-11 2021 Furthermore, TMP intervention participated in the inhibition of NLRP3 inflammasome accompanied with pyroptosis, as well as upregulating Trx expression and downregulating p-NF-kappaB, while the protective effect of TMP was limited to the involvement of Txnip overexpression. Thymidine Monophosphate 13-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 172-181 33716060-11 2021 Furthermore, TMP intervention participated in the inhibition of NLRP3 inflammasome accompanied with pyroptosis, as well as upregulating Trx expression and downregulating p-NF-kappaB, while the protective effect of TMP was limited to the involvement of Txnip overexpression. Thymidine Monophosphate 13-16 thioredoxin interacting protein Mus musculus 252-257 33716060-12 2021 SIGNIFICANCE: TMP treatment could significantly alleviate the hepatotoxicity process as evidenced by improving the structure and function of the liver, inhibiting oxidative stress and inflammation accompanied with pyroptosis, which was positively correlated with the inhibition of Txnip/Trx/NF-kappaB pathway. Thymidine Monophosphate 14-17 thioredoxin interacting protein Mus musculus 281-286 33716060-12 2021 SIGNIFICANCE: TMP treatment could significantly alleviate the hepatotoxicity process as evidenced by improving the structure and function of the liver, inhibiting oxidative stress and inflammation accompanied with pyroptosis, which was positively correlated with the inhibition of Txnip/Trx/NF-kappaB pathway. Thymidine Monophosphate 14-17 thioredoxin 1 Mus musculus 287-290 33716060-12 2021 SIGNIFICANCE: TMP treatment could significantly alleviate the hepatotoxicity process as evidenced by improving the structure and function of the liver, inhibiting oxidative stress and inflammation accompanied with pyroptosis, which was positively correlated with the inhibition of Txnip/Trx/NF-kappaB pathway. Thymidine Monophosphate 14-17 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 291-300 33112793-8 2020 After TMP treatment, autophagosome formation was reduced in trophoblast cells of placental tissue of PE rats, along with downregulation of autophagy-related proteins Light Chain 3 (LC3)-II/LC3-I, Beclin1 (BECN1), and SQSTM1. Thymidine Monophosphate 6-9 beclin 1 Rattus norvegicus 196-203 33486616-1 2021 Human thymidylate synthase (hTS) is a 72 kDa homodimeric enzyme responsible for the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), making it the sole source of de novo dTMP in human cells. Thymidine Monophosphate 135-163 thymidylate synthetase Homo sapiens 6-26 33486616-1 2021 Human thymidylate synthase (hTS) is a 72 kDa homodimeric enzyme responsible for the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), making it the sole source of de novo dTMP in human cells. Thymidine Monophosphate 135-163 APC down-regulated 1 Homo sapiens 28-31 33486616-1 2021 Human thymidylate synthase (hTS) is a 72 kDa homodimeric enzyme responsible for the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), making it the sole source of de novo dTMP in human cells. Thymidine Monophosphate 165-169 thymidylate synthetase Homo sapiens 6-26 33486616-1 2021 Human thymidylate synthase (hTS) is a 72 kDa homodimeric enzyme responsible for the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), making it the sole source of de novo dTMP in human cells. Thymidine Monophosphate 165-169 APC down-regulated 1 Homo sapiens 28-31 33486616-1 2021 Human thymidylate synthase (hTS) is a 72 kDa homodimeric enzyme responsible for the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), making it the sole source of de novo dTMP in human cells. Thymidine Monophosphate 209-213 thymidylate synthetase Homo sapiens 6-26 33486616-1 2021 Human thymidylate synthase (hTS) is a 72 kDa homodimeric enzyme responsible for the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), making it the sole source of de novo dTMP in human cells. Thymidine Monophosphate 209-213 APC down-regulated 1 Homo sapiens 28-31 33829766-1 2021 Methylation of 2-deoxyuridine-5"-monophosphate (dUMP) at the C5 position by the obligate dimeric thymidylate synthase (TSase) in the sole de novo biosynthetic pathway to thymidine 5"-monophosphate (dTMP) proceeds by forming a covalent ternary complex with dUMP and cosubstrate 5,10-methylenetetrahydrofolate. Thymidine Monophosphate 198-202 thymidylate synthetase Homo sapiens 97-117 33829766-1 2021 Methylation of 2-deoxyuridine-5"-monophosphate (dUMP) at the C5 position by the obligate dimeric thymidylate synthase (TSase) in the sole de novo biosynthetic pathway to thymidine 5"-monophosphate (dTMP) proceeds by forming a covalent ternary complex with dUMP and cosubstrate 5,10-methylenetetrahydrofolate. Thymidine Monophosphate 198-202 thymidylate synthetase Homo sapiens 119-124 33917576-2 2021 Combining mesenchymal stem cells (MSCs) and growth factor-loaded ADM for the regeneration of chronic TMP has not been reported so far. Thymidine Monophosphate 101-104 myotrophin Rattus norvegicus 44-57 33917576-3 2021 In this study, we hypothesized that combining growth factor-loaded ADM/MSCs could promote the recruitment of MSCs and assist in TMP regeneration. Thymidine Monophosphate 128-131 myotrophin Rattus norvegicus 46-59 33112793-8 2020 After TMP treatment, autophagosome formation was reduced in trophoblast cells of placental tissue of PE rats, along with downregulation of autophagy-related proteins Light Chain 3 (LC3)-II/LC3-I, Beclin1 (BECN1), and SQSTM1. Thymidine Monophosphate 6-9 beclin 1 Rattus norvegicus 205-210 33112793-8 2020 After TMP treatment, autophagosome formation was reduced in trophoblast cells of placental tissue of PE rats, along with downregulation of autophagy-related proteins Light Chain 3 (LC3)-II/LC3-I, Beclin1 (BECN1), and SQSTM1. Thymidine Monophosphate 6-9 sequestosome 1 Rattus norvegicus 217-223 33112793-12 2020 Further in vivo experiments validated that TMP impeded PE progression in rats by regulating the miR-16-5p/IGF-2 axis. Thymidine Monophosphate 43-46 insulin-like growth factor 2 Rattus norvegicus 106-111 33112793-13 2020 In summary, TMP inhibits trophoblast cell autophagy and promotes its viability and migration in PE rat model through regulating the miR-16-5p/IGF-2 axis. Thymidine Monophosphate 12-15 insulin-like growth factor 2 Rattus norvegicus 142-147 32853828-5 2020 Moreover, the nicked repair intermediates that mimic pol beta mismatch insertion products, i.e., with 3"-preinserted dGMP or dTMP opposite templating 5hmC, 5fC or 5caC, can be efficiently ligated, whereas preinserted 3"-dAMP or dCMP mismatches result in failed ligation reactions. Thymidine Monophosphate 125-129 DNA polymerase alpha 1, catalytic subunit Homo sapiens 53-61 33350210-17 2020 Experimental results show that pEGF-CS-TMP-NPs have an active targeting effect on MCF-7/ADR cells with high EGFR expression, and can effectively reverse the multidrug resistance of MCF-7/ADR cells. Thymidine Monophosphate 39-42 epidermal growth factor receptor Homo sapiens 108-112 32717805-1 2020 Thymidine kinase 1 (TK1) phosphorylates thymidine nucleosides to generate thymidine monophosphate. Thymidine Monophosphate 74-97 thymidine kinase Zea mays 20-23 32345121-1 2020 Thymidylate kinase (TMPK, EC2.7.4.9) is the enzyme that converts deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP) in the synthesis of dTTP, an essential building block of DNA. Thymidine Monophosphate 65-93 deoxythymidylate kinase Homo sapiens 0-18 32271909-11 2020 p53-/- MEFs had 55% higher rates of folate-dependent de novo dTMP synthesis, a ~2-fold higher accumulation of uracil in DNA, and a ~30% higher rate of proliferation (P <= 0.05) than p53+/- MEFs independent of folate. Thymidine Monophosphate 61-65 transformation related protein 53, pseudogene Mus musculus 0-3 32271909-13 2020 Increased dTMP synthesis in p53-/- MEFs might not have been sufficient to meet the demands for thymidine triphosphate (dTTP) synthesis as evidenced by the elevated amounts of uracil in DNA. Thymidine Monophosphate 10-14 transformation related protein 53, pseudogene Mus musculus 28-31 32715203-1 2020 Thymidylate synthase is an enzyme that catalyzes deoxythymidine monophosphate (dTMP) synthesis from substrate deoxyuridine monophosphate (dUMP). Thymidine Monophosphate 49-77 thymidylate synthetase Homo sapiens 0-20 32715203-1 2020 Thymidylate synthase is an enzyme that catalyzes deoxythymidine monophosphate (dTMP) synthesis from substrate deoxyuridine monophosphate (dUMP). Thymidine Monophosphate 79-83 thymidylate synthetase Homo sapiens 0-20 32266101-6 2020 Further, TMP reverted epirubicin resistance by inhibiting JAK2/STAT3 signaling and decreasing FGG expression. Thymidine Monophosphate 9-12 Janus kinase 2 Homo sapiens 58-62 32266101-6 2020 Further, TMP reverted epirubicin resistance by inhibiting JAK2/STAT3 signaling and decreasing FGG expression. Thymidine Monophosphate 9-12 signal transducer and activator of transcription 3 Homo sapiens 63-68 32266101-6 2020 Further, TMP reverted epirubicin resistance by inhibiting JAK2/STAT3 signaling and decreasing FGG expression. Thymidine Monophosphate 9-12 fibrinogen gamma chain Homo sapiens 94-97 32266101-10 2020 TMP was a novel chemosensitizer for FGG-induced anthracycline chemoresistance in breast cancer treatment. Thymidine Monophosphate 0-3 fibrinogen gamma chain Homo sapiens 36-39 31682800-6 2020 In addition, the primary basilar artery smooth muscle cells (BASMCs) were cultured and TMP protection of BASMCs stimulated with ET-1/Ang II in the presence or absence of insulin-like growth factor 1 (IGF-1) was determined. Thymidine Monophosphate 87-90 endothelin 1 Rattus norvegicus 128-132 31682800-6 2020 In addition, the primary basilar artery smooth muscle cells (BASMCs) were cultured and TMP protection of BASMCs stimulated with ET-1/Ang II in the presence or absence of insulin-like growth factor 1 (IGF-1) was determined. Thymidine Monophosphate 87-90 angiotensinogen Rattus norvegicus 133-139 31682800-7 2020 RESULTS: TMP attenuated basilar artery remodeling, decreased ET-1 and Ang II levels and increased NO level in basilar arteries and plasma of RHRSP rats. Thymidine Monophosphate 9-12 endothelin 1 Rattus norvegicus 61-65 31682800-7 2020 RESULTS: TMP attenuated basilar artery remodeling, decreased ET-1 and Ang II levels and increased NO level in basilar arteries and plasma of RHRSP rats. Thymidine Monophosphate 9-12 angiotensinogen Rattus norvegicus 70-76 31682800-8 2020 Moreover, TMP reduced BASMCs proliferation upon ET-1/Ang II stimulation. Thymidine Monophosphate 10-13 endothelin 1 Rattus norvegicus 48-52 31682800-8 2020 Moreover, TMP reduced BASMCs proliferation upon ET-1/Ang II stimulation. Thymidine Monophosphate 10-13 angiotensinogen Rattus norvegicus 53-59 31682800-9 2020 We also found that TMP could effectively suppress the activation of PI3K/Akt in 2k2c-RHRSP rat basilar artery and ET-1/Ang II stimulated BASMCs. Thymidine Monophosphate 19-22 AKT serine/threonine kinase 1 Rattus norvegicus 73-76 31682800-9 2020 We also found that TMP could effectively suppress the activation of PI3K/Akt in 2k2c-RHRSP rat basilar artery and ET-1/Ang II stimulated BASMCs. Thymidine Monophosphate 19-22 endothelin 1 Rattus norvegicus 114-118 31682800-9 2020 We also found that TMP could effectively suppress the activation of PI3K/Akt in 2k2c-RHRSP rat basilar artery and ET-1/Ang II stimulated BASMCs. Thymidine Monophosphate 19-22 angiotensinogen Rattus norvegicus 119-125 31682800-10 2020 Most importantly, IGF-1, as an activator of PI3K/Akt, could damage the protective effect of TMP. Thymidine Monophosphate 92-95 insulin-like growth factor 1 Rattus norvegicus 18-23 31682800-10 2020 Most importantly, IGF-1, as an activator of PI3K/Akt, could damage the protective effect of TMP. Thymidine Monophosphate 92-95 AKT serine/threonine kinase 1 Rattus norvegicus 49-52 31682800-11 2020 CONCLUSIONS: TMP exerts its protective effects and prevents basilar artery remodeling in RHRSP rats at least partly through the inhibition of PI3K/Akt pathway. Thymidine Monophosphate 13-16 AKT serine/threonine kinase 1 Rattus norvegicus 147-150 32345121-1 2020 Thymidylate kinase (TMPK, EC2.7.4.9) is the enzyme that converts deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP) in the synthesis of dTTP, an essential building block of DNA. Thymidine Monophosphate 65-93 deoxythymidylate kinase Homo sapiens 20-24 32345121-1 2020 Thymidylate kinase (TMPK, EC2.7.4.9) is the enzyme that converts deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP) in the synthesis of dTTP, an essential building block of DNA. Thymidine Monophosphate 95-99 deoxythymidylate kinase Homo sapiens 0-18 32345121-1 2020 Thymidylate kinase (TMPK, EC2.7.4.9) is the enzyme that converts deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP) in the synthesis of dTTP, an essential building block of DNA. Thymidine Monophosphate 95-99 deoxythymidylate kinase Homo sapiens 20-24 31172516-1 2019 Thymidylate synthase (TS), found in all organisms, is an essential enzyme responsible for the de novo synthesis of deoxythymidine monophosphate. Thymidine Monophosphate 115-143 thymidylate synthetase Homo sapiens 0-20 31630149-2 2020 Thymidylate synthase (TS) is an essential enzyme for the de novo synthesis of deoxythymidine monophosphate; we had found that knocking down the expression of TS sensitizes lung cancer cells to cisplatin-induced cytotoxicity. Thymidine Monophosphate 78-106 thymidylate synthetase Homo sapiens 0-20 31630149-2 2020 Thymidylate synthase (TS) is an essential enzyme for the de novo synthesis of deoxythymidine monophosphate; we had found that knocking down the expression of TS sensitizes lung cancer cells to cisplatin-induced cytotoxicity. Thymidine Monophosphate 78-106 thymidylate synthetase Homo sapiens 22-24 31630149-2 2020 Thymidylate synthase (TS) is an essential enzyme for the de novo synthesis of deoxythymidine monophosphate; we had found that knocking down the expression of TS sensitizes lung cancer cells to cisplatin-induced cytotoxicity. Thymidine Monophosphate 78-106 thymidylate synthetase Homo sapiens 158-160 31705139-0 2019 A host dTMP-bound structure of T4 phage dCMP hydroxymethylase mutant using an X-ray free electron laser. Thymidine Monophosphate 7-11 cmp Drosophila melanogaster 40-44 31705139-8 2019 The bound dTMP mimicked the methylene intermediate from dCMP to 5"-hydroxymethy-dCMP, and a critical water molecule for the final hydroxylation was convincingly identified. Thymidine Monophosphate 10-14 cmp Drosophila melanogaster 56-60 31705139-8 2019 The bound dTMP mimicked the methylene intermediate from dCMP to 5"-hydroxymethy-dCMP, and a critical water molecule for the final hydroxylation was convincingly identified. Thymidine Monophosphate 10-14 cmp Drosophila melanogaster 80-84 31970106-9 2019 The median CD4 count increased from 91 cells/mm3 pre-trimethoprim/sulfamethoxazole (TMP/SMX) to an estimated 263 cells/mm3 after starting (TMP/SMX). Thymidine Monophosphate 84-87 CD4 molecule Homo sapiens 11-14 31970106-9 2019 The median CD4 count increased from 91 cells/mm3 pre-trimethoprim/sulfamethoxazole (TMP/SMX) to an estimated 263 cells/mm3 after starting (TMP/SMX). Thymidine Monophosphate 139-142 CD4 molecule Homo sapiens 11-14 31498585-3 2019 In this work, a low-dielectric diluent, 1,1,2,2-tetrafluoroethyl 2,2,3,3,-tetrafluoropropyl ether (HFE), is introduced into concentrated LiFSA/TMP electrolytes. Thymidine Monophosphate 143-146 homeostatic iron regulator Homo sapiens 99-102 31498585-6 2019 A spectroscopic analysis shows that the diluted LiFSA/TMP:HFE has a local coordination state similar to that in the concentrated LiFSA/TMP, which leads to the formation of a FSA anion-derived inorganic surface film. Thymidine Monophosphate 54-57 homeostatic iron regulator Homo sapiens 58-61 31498585-6 2019 A spectroscopic analysis shows that the diluted LiFSA/TMP:HFE has a local coordination state similar to that in the concentrated LiFSA/TMP, which leads to the formation of a FSA anion-derived inorganic surface film. Thymidine Monophosphate 135-138 homeostatic iron regulator Homo sapiens 58-61 31450426-8 2019 By continuous infusion of substrate into the bioreactors, the conversion of thymidine monophosphate (dTMP) into its di- (dTDP) and tri-phosphorylated (dTTP) forms was visualized by monitoring their Extracted Ion Chromatogram (EIC) of their [M - H]- ions. Thymidine Monophosphate 76-99 TAR DNA-binding protein-43 homolog Drosophila melanogaster 121-125 31450426-8 2019 By continuous infusion of substrate into the bioreactors, the conversion of thymidine monophosphate (dTMP) into its di- (dTDP) and tri-phosphorylated (dTTP) forms was visualized by monitoring their Extracted Ion Chromatogram (EIC) of their [M - H]- ions. Thymidine Monophosphate 101-105 TAR DNA-binding protein-43 homolog Drosophila melanogaster 121-125 31565920-6 2019 Here, we report a series of INCA compounds that exhibit low nanomolar enzymatic activity and potent cellular activity with human selectivity against a panel of clinically relevant TMP resistant (TMPR) and methicillin resistant Staphylococcus aureus (MRSA) isolates. Thymidine Monophosphate 180-183 caspase recruitment domain family member 17 Homo sapiens 28-32 31500803-1 2019 Thymidylate synthase (TS) catalyzes the production of the nucleotide dTMP from deoxyuridine monophosphate (dUMP), making the enzyme necessary for DNA replication and consequently a target for cancer therapeutics. Thymidine Monophosphate 69-73 thymidylate synthetase Homo sapiens 0-20 30447376-3 2019 TMPK catalyses the conversion of Thymidine mono-phosphate (TMP) to TDP using ATP as phosphoryl donor in the presence of Mg2+ ion. Thymidine Monophosphate 33-57 deoxythymidylate kinase Homo sapiens 0-4 30935102-1 2019 Thymidylate synthase (TS) is an enzyme of paramount importance as it provides the only de novo source of deoxy-thymidine monophosphate (dTMP). Thymidine Monophosphate 105-134 thymidylate synthetase Homo sapiens 0-20 30935102-1 2019 Thymidylate synthase (TS) is an enzyme of paramount importance as it provides the only de novo source of deoxy-thymidine monophosphate (dTMP). Thymidine Monophosphate 136-140 thymidylate synthetase Homo sapiens 0-20 30959951-1 2019 Human thymidylate synthase (hTS) is pivotal for cell survival and proliferation, indeed it provides the only synthetic source of dTMP, required for DNA biosynthesis. Thymidine Monophosphate 129-133 thymidylate synthetase Homo sapiens 6-26 30959951-1 2019 Human thymidylate synthase (hTS) is pivotal for cell survival and proliferation, indeed it provides the only synthetic source of dTMP, required for DNA biosynthesis. Thymidine Monophosphate 129-133 APC down-regulated 1 Homo sapiens 28-31 30199284-2 2019 Thymidylate kinase (TMPK) catalyzes the conversion of thymidine monophosphate to thymidine diphosphate, which is an essential step for dTTP synthesis. Thymidine Monophosphate 54-77 deoxythymidylate kinase Homo sapiens 0-18 30728402-1 2019 Resistance to 5-Fluoruracil (5-FU) has been linked to elevated expression of the main target, thymidylate synthase (TYMS), which catalyses the de novo pathway for production of deoxythymidine monophosphate. Thymidine Monophosphate 177-205 thymidylate synthetase Homo sapiens 94-114 30728402-1 2019 Resistance to 5-Fluoruracil (5-FU) has been linked to elevated expression of the main target, thymidylate synthase (TYMS), which catalyses the de novo pathway for production of deoxythymidine monophosphate. Thymidine Monophosphate 177-205 thymidylate synthetase Homo sapiens 116-120 30199284-2 2019 Thymidylate kinase (TMPK) catalyzes the conversion of thymidine monophosphate to thymidine diphosphate, which is an essential step for dTTP synthesis. Thymidine Monophosphate 54-77 deoxythymidylate kinase Homo sapiens 20-24 30574873-3 2019 The cellular enzyme thymidylate synthase (TS) catalyses the conversion of dUMP to TMP, which is converted to TDP and ultimately to TTP, a building block in DNA synthesis. Thymidine Monophosphate 82-85 thymidylate synthetase Homo sapiens 20-40 30180988-2 2019 Thymidylate synthase (TYMS) is a key enzyme in DNA synthesis that catalyzes the conversion of deoxyuridine monophosphate to dTMP. Thymidine Monophosphate 124-128 thymidylate synthetase Homo sapiens 0-20 30180988-2 2019 Thymidylate synthase (TYMS) is a key enzyme in DNA synthesis that catalyzes the conversion of deoxyuridine monophosphate to dTMP. Thymidine Monophosphate 124-128 thymidylate synthetase Homo sapiens 22-26 30317699-3 2019 Thymidine kinase (TK) is the first enzyme in the salvage pathway to recycle thymidine nucleosides as it phosphorylates thymidine to yield thymidine monophosphate. Thymidine Monophosphate 138-161 Thymidine kinase Arabidopsis thaliana 0-16 30317699-3 2019 Thymidine kinase (TK) is the first enzyme in the salvage pathway to recycle thymidine nucleosides as it phosphorylates thymidine to yield thymidine monophosphate. Thymidine Monophosphate 138-161 Thymidine kinase Arabidopsis thaliana 18-20 30035852-0 2018 The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells. Thymidine Monophosphate 91-95 serine hydroxymethyltransferase 1 Homo sapiens 26-57 30259810-3 2019 Impairment of thymidylate (dTMP) biosynthesis severely diminishes the viability of parasitic protozoa and the absence of enzymatic activities specifically involved in the formation of dTMP (e.g. dUTPase, thymidylate synthase, dihydrofolate reductase or thymidine kinase) results in decreased deoxythymidine triphosphate (dTTP) levels and the so-called thymineless death. Thymidine Monophosphate 27-31 thymidylate synthetase Homo sapiens 204-224 30259810-3 2019 Impairment of thymidylate (dTMP) biosynthesis severely diminishes the viability of parasitic protozoa and the absence of enzymatic activities specifically involved in the formation of dTMP (e.g. dUTPase, thymidylate synthase, dihydrofolate reductase or thymidine kinase) results in decreased deoxythymidine triphosphate (dTTP) levels and the so-called thymineless death. Thymidine Monophosphate 184-188 Deoxyuridine triphosphatase Drosophila melanogaster 195-202 30259810-3 2019 Impairment of thymidylate (dTMP) biosynthesis severely diminishes the viability of parasitic protozoa and the absence of enzymatic activities specifically involved in the formation of dTMP (e.g. dUTPase, thymidylate synthase, dihydrofolate reductase or thymidine kinase) results in decreased deoxythymidine triphosphate (dTTP) levels and the so-called thymineless death. Thymidine Monophosphate 184-188 thymidylate synthetase Homo sapiens 204-224 30385507-5 2018 Depressed MPV17 expression reduced mitochondrial folate levels by 43% and increased uracil levels, a marker of impaired dTMP synthesis, in mtDNA by 3-fold. Thymidine Monophosphate 120-124 mitochondrial inner membrane protein MPV17 Homo sapiens 10-15 30385507-7 2018 These results indicate that MPV17 provides a third dTMP source, potentially by serving as a transporter that transfers dTMP from the cytosol to mitochondria to sustain mtDNA synthesis. Thymidine Monophosphate 51-55 mitochondrial inner membrane protein MPV17 Homo sapiens 28-33 30385507-7 2018 These results indicate that MPV17 provides a third dTMP source, potentially by serving as a transporter that transfers dTMP from the cytosol to mitochondria to sustain mtDNA synthesis. Thymidine Monophosphate 119-123 mitochondrial inner membrane protein MPV17 Homo sapiens 28-33 30385507-8 2018 We propose that MPV17 loss-of-function and related hepatocerebral MDS are linked to impaired FOCM in mitochondria by providing insufficient access to cytosolic dTMP pools and by severely reducing mitochondrial folate pools. Thymidine Monophosphate 160-164 mitochondrial inner membrane protein MPV17 Homo sapiens 16-21 30021362-10 2018 The protective role of TMP further confirmed by measuring the lesion area with the 2,3,5-triphenyltetrazolium chloride staining of the brain slices and histopathological alteration in the hippocampus (CA1 and CA3) and striatal regions of the brain. Thymidine Monophosphate 23-26 carbonic anhydrase 1 Rattus norvegicus 201-204 30021362-10 2018 The protective role of TMP further confirmed by measuring the lesion area with the 2,3,5-triphenyltetrazolium chloride staining of the brain slices and histopathological alteration in the hippocampus (CA1 and CA3) and striatal regions of the brain. Thymidine Monophosphate 23-26 carbonic anhydrase 3 Rattus norvegicus 209-212