PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
833134-2	1977	When cell cultures were incubated with certain oxygenated derivatives of cholesterol which specifically depress 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity (i.e. 25-hydroxycholesterol, 7-ketocholesterol, or 20 alpha-hydroxycholesterol), a number of consequences followed the decline in enzyme activity.	7-ketocholesterol	198-215	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	112-159
833506-6	1977	Similar treatment of the animals with 7-ketocholesterol, a cholesterol derivative reported to repress HMG CoA reductase activity in tissue cultures, produced no appreciable difference in reductase activity or serum steroid levels in vivo.	7-ketocholesterol	38-55	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	102-119
33409276-4	2020	In the present study, we found that in cultured carotid ECs, atherogenic stimulation by oxysterol 7-ketocholesterol (7-Ket) induced NLRP3 inflammasome formation and activation, reduced lysosome-multivesicular bodies (MVBs) fusion, and increased secretion of EVs that contain inflammasome product IL-1beta.	7-ketocholesterol	98-115	NLR family, pyrin domain containing 3	Mus musculus	132-137
1252410-4	1976	When 7-ketocholesterol was added, the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase was markedly suppressed in both normal and abnormal lymphoid cell lines.	7-ketocholesterol	5-22	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	50-97
34023424-0	2021	7-ketocholesterol enhances autophagy via the ROS-TFEB signaling pathway in osteoclasts: 7-KC in osteoclasts.	7-ketocholesterol	0-17	transcription factor EB	Homo sapiens	49-53
33409276-4	2020	In the present study, we found that in cultured carotid ECs, atherogenic stimulation by oxysterol 7-ketocholesterol (7-Ket) induced NLRP3 inflammasome formation and activation, reduced lysosome-multivesicular bodies (MVBs) fusion, and increased secretion of EVs that contain inflammasome product IL-1beta.	7-ketocholesterol	98-115	interleukin 1 alpha	Mus musculus	296-304
33409276-4	2020	In the present study, we found that in cultured carotid ECs, atherogenic stimulation by oxysterol 7-ketocholesterol (7-Ket) induced NLRP3 inflammasome formation and activation, reduced lysosome-multivesicular bodies (MVBs) fusion, and increased secretion of EVs that contain inflammasome product IL-1beta.	7-ketocholesterol	117-122	NLR family, pyrin domain containing 3	Mus musculus	132-137
33409276-4	2020	In the present study, we found that in cultured carotid ECs, atherogenic stimulation by oxysterol 7-ketocholesterol (7-Ket) induced NLRP3 inflammasome formation and activation, reduced lysosome-multivesicular bodies (MVBs) fusion, and increased secretion of EVs that contain inflammasome product IL-1beta.	7-ketocholesterol	117-122	interleukin 1 alpha	Mus musculus	296-304
33409276-6	2020	Moreover, acid ceramidase (AC) deficiency or lysosome inhibition further exaggerated the 7-Ket-induced release of IL-1beta-containing EVs in ECs.	7-ketocholesterol	89-94	N-acylsphingosine amidohydrolase 1	Mus musculus	10-25
33409276-6	2020	Moreover, acid ceramidase (AC) deficiency or lysosome inhibition further exaggerated the 7-Ket-induced release of IL-1beta-containing EVs in ECs.	7-ketocholesterol	89-94	interleukin 1 alpha	Mus musculus	114-122
32771556-0	2020	3beta-Hydroxycholest-5-en-7-one from seahorse alleviates lipopolysaccharide-induced inflammatory responses by downregulating miR-98-5p.	7-ketocholesterol	0-31	microRNA 98	Mus musculus	125-131
32940860-9	2020	In vitro studies indicated that 7-keto-induced senescence of EPCs was at least via the activation of the Notch1 pathway.	7-ketocholesterol	32-38	notch 1	Mus musculus	105-111
32940860-10	2020	Mechanistic data suggested that 7-keto may activate the Notch1 pathway by regulating the generation and transport of NICD to the nucleus.	7-ketocholesterol	32-38	notch 1	Mus musculus	56-62
33017620-5	2020	After CHO cells were treated with 25 muM 7-ketocholesterol for 48 h, the mutation frequency at hprt gene loci and the level of gamma-H2AX protein were both significantly increased.	7-ketocholesterol	41-58	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	95-99
33017620-6	2020	Exposure to 7-ketocholesterol resulted in a concentration-dependent increase in the apoptotic rate and the protein expression of cleaved caspase-3 and -7 in CHO cells.	7-ketocholesterol	12-29	caspase-3	Cricetulus griseus	137-153
32771556-7	2020	Our results demonstrated that 3beta-hydroxycholest-5-en-7-one exerted an anti-inflammatory effect via miR-98-5p, which negatively regulated the expression of its target gene TNFAIP3.	7-ketocholesterol	30-61	microRNA 98	Mus musculus	102-108
32771556-7	2020	Our results demonstrated that 3beta-hydroxycholest-5-en-7-one exerted an anti-inflammatory effect via miR-98-5p, which negatively regulated the expression of its target gene TNFAIP3.	7-ketocholesterol	30-61	tumor necrosis factor, alpha-induced protein 3	Mus musculus	174-181
32771556-8	2020	The results indicate that miR-98-5p interference and 3beta-hydroxycholest-5-en-7-one treatment significantly upregulated the low TNFAIP3 expression induced by LPS stimulation, thereby inhibiting TRAF6, RIP, NF-kappaB, IL-1beta, and TNF-alpha secretion.	7-ketocholesterol	53-84	tumor necrosis factor, alpha-induced protein 3	Mus musculus	129-136
32771556-8	2020	The results indicate that miR-98-5p interference and 3beta-hydroxycholest-5-en-7-one treatment significantly upregulated the low TNFAIP3 expression induced by LPS stimulation, thereby inhibiting TRAF6, RIP, NF-kappaB, IL-1beta, and TNF-alpha secretion.	7-ketocholesterol	53-84	TNF receptor-associated factor 6	Mus musculus	195-200
32771556-8	2020	The results indicate that miR-98-5p interference and 3beta-hydroxycholest-5-en-7-one treatment significantly upregulated the low TNFAIP3 expression induced by LPS stimulation, thereby inhibiting TRAF6, RIP, NF-kappaB, IL-1beta, and TNF-alpha secretion.	7-ketocholesterol	53-84	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	207-216
32771556-8	2020	The results indicate that miR-98-5p interference and 3beta-hydroxycholest-5-en-7-one treatment significantly upregulated the low TNFAIP3 expression induced by LPS stimulation, thereby inhibiting TRAF6, RIP, NF-kappaB, IL-1beta, and TNF-alpha secretion.	7-ketocholesterol	53-84	interleukin 1 alpha	Mus musculus	218-226
32771556-8	2020	The results indicate that miR-98-5p interference and 3beta-hydroxycholest-5-en-7-one treatment significantly upregulated the low TNFAIP3 expression induced by LPS stimulation, thereby inhibiting TRAF6, RIP, NF-kappaB, IL-1beta, and TNF-alpha secretion.	7-ketocholesterol	53-84	tumor necrosis factor	Mus musculus	232-241
32771556-9	2020	SIGNIFICANCE: 3beta-Hydroxycholest-5-en-7-one alleviates inflammation by downregulating miR-98-5p and upregulating TNFAIP3, thereby blocking NF-kappaB pathway activation.	7-ketocholesterol	14-45	microRNA 98	Mus musculus	88-94
32771556-9	2020	SIGNIFICANCE: 3beta-Hydroxycholest-5-en-7-one alleviates inflammation by downregulating miR-98-5p and upregulating TNFAIP3, thereby blocking NF-kappaB pathway activation.	7-ketocholesterol	14-45	tumor necrosis factor, alpha-induced protein 3	Mus musculus	115-122
32771556-9	2020	SIGNIFICANCE: 3beta-Hydroxycholest-5-en-7-one alleviates inflammation by downregulating miR-98-5p and upregulating TNFAIP3, thereby blocking NF-kappaB pathway activation.	7-ketocholesterol	14-45	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	141-150
29778664-11	2018	Liver-X receptor activation in control HPEC by synthetic agonist TO901319, 7-ketocholesterol, or 7beta-hydroxycholesterol upregulated ATP-binding cassette transporters (ABC)A1 and ABCG1 expression, accompanied by increased cellular cholesterol efflux.	7-ketocholesterol	75-92	ATP binding cassette subfamily G member 1	Homo sapiens	180-185
31823799-0	2019	CPT1a gene expression reverses the inflammatory and anti-phagocytic effect of 7-ketocholesterol in RAW264.7 macrophages.	7-ketocholesterol	78-95	carnitine palmitoyltransferase 1a, liver	Mus musculus	0-5
31823799-5	2019	METHODS: Using a murine macrophage cell line, RAW264.7, we determine if intracellular accumulation of 7-ketocholesterol (7-KC) modulates macrophage phagocytic function through CPT1a gene expression.	7-ketocholesterol	102-119	carnitine palmitoyltransferase 1a, liver	Mus musculus	176-181
31823799-5	2019	METHODS: Using a murine macrophage cell line, RAW264.7, we determine if intracellular accumulation of 7-ketocholesterol (7-KC) modulates macrophage phagocytic function through CPT1a gene expression.	7-ketocholesterol	121-125	carnitine palmitoyltransferase 1a, liver	Mus musculus	176-181
31823799-7	2019	RESULTS: Our results revealed that CPT1a gene expression decreased by the accumulation of 7-KC at the higher dose of 7-KC.	7-ketocholesterol	90-94	carnitine palmitoyltransferase 1a, liver	Mus musculus	35-40
31823799-7	2019	RESULTS: Our results revealed that CPT1a gene expression decreased by the accumulation of 7-KC at the higher dose of 7-KC.	7-ketocholesterol	117-121	carnitine palmitoyltransferase 1a, liver	Mus musculus	35-40
31655042-0	2019	7-Ketocholesterol disturbs RPE cells phagocytosis of the outer segment of photoreceptor and induces inflammation through ERK signaling pathway.	7-ketocholesterol	0-17	Eph receptor B1	Rattus norvegicus	121-124
31405564-3	2019	In the present study, we investigated whether the accumulation of lipids induced by 7-ketocholesterol (7-KC) in tubular epithelial cells produce a fibrotic and inflammatory response through CPT1a.	7-ketocholesterol	84-101	carnitine palmitoyltransferase 1A	Homo sapiens	190-195
31405564-3	2019	In the present study, we investigated whether the accumulation of lipids induced by 7-ketocholesterol (7-KC) in tubular epithelial cells produce a fibrotic and inflammatory response through CPT1a.	7-ketocholesterol	103-107	carnitine palmitoyltransferase 1A	Homo sapiens	190-195
31405564-4	2019	METHODS: Using an epithelial cell line, NRK-52E, we determine if intracellular accumulation of 7-KC modulates profibrotic and inflammatory events through CPT1a gene expression.	7-ketocholesterol	95-99	carnitine palmitoyltransferase 1A	Homo sapiens	154-159
30753095-1	2019	Our objective was to investigate the effect of cholesterol [hypercholesterolemia and 7-ketocholesterol (7K)] on endoglin (Eng) expression and regulation with respect to endothelial or vascular dysfunction in vivo and in vitro.	7-ketocholesterol	85-102	endoglin	Mus musculus	112-120
30753095-1	2019	Our objective was to investigate the effect of cholesterol [hypercholesterolemia and 7-ketocholesterol (7K)] on endoglin (Eng) expression and regulation with respect to endothelial or vascular dysfunction in vivo and in vitro.	7-ketocholesterol	85-102	endoglin	Mus musculus	122-125
31463370-0	2019	7-Ketocholesterol and cholestane-triol increase expression of SMO and LXRalpha signaling pathways in a human breast cancer cell line.	7-ketocholesterol	0-17	smoothened, frizzled class receptor	Homo sapiens	62-65
31463370-0	2019	7-Ketocholesterol and cholestane-triol increase expression of SMO and LXRalpha signaling pathways in a human breast cancer cell line.	7-ketocholesterol	0-17	nuclear receptor subfamily 1 group H member 3	Homo sapiens	70-78
31463370-10	2019	These results suggested that the sonic hedgehog and LXRalpha pathways might be involved in the apoptotic process promoted by 7-KC and triol.	7-ketocholesterol	125-129	nuclear receptor subfamily 1 group H member 3	Homo sapiens	52-60
30273598-2	2018	We first demonstrated that 7-ketocholesterol stimulated Nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [Nlrp3 versus apoptosis associated speck-like protein (Asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate IL-1beta in coronary artery smooth muscle cells.	7-ketocholesterol	27-44	NLR family, pyrin domain containing 3	Mus musculus	56-61
30273598-2	2018	We first demonstrated that 7-ketocholesterol stimulated Nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [Nlrp3 versus apoptosis associated speck-like protein (Asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate IL-1beta in coronary artery smooth muscle cells.	7-ketocholesterol	27-44	NLR family, pyrin domain containing 3	Mus musculus	165-170
30273598-2	2018	We first demonstrated that 7-ketocholesterol stimulated Nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [Nlrp3 versus apoptosis associated speck-like protein (Asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate IL-1beta in coronary artery smooth muscle cells.	7-ketocholesterol	27-44	PYD and CARD domain containing	Mus musculus	219-222
30273598-2	2018	We first demonstrated that 7-ketocholesterol stimulated Nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [Nlrp3 versus apoptosis associated speck-like protein (Asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate IL-1beta in coronary artery smooth muscle cells.	7-ketocholesterol	27-44	caspase 1	Mus musculus	227-236
30273598-2	2018	We first demonstrated that 7-ketocholesterol stimulated Nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [Nlrp3 versus apoptosis associated speck-like protein (Asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate IL-1beta in coronary artery smooth muscle cells.	7-ketocholesterol	27-44	caspase 1	Mus musculus	263-272
30273598-2	2018	We first demonstrated that 7-ketocholesterol stimulated Nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [Nlrp3 versus apoptosis associated speck-like protein (Asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate IL-1beta in coronary artery smooth muscle cells.	7-ketocholesterol	27-44	caspase 1	Mus musculus	263-272
30273598-2	2018	We first demonstrated that 7-ketocholesterol stimulated Nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [Nlrp3 versus apoptosis associated speck-like protein (Asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate IL-1beta in coronary artery smooth muscle cells.	7-ketocholesterol	27-44	interleukin 1 beta	Mus musculus	307-315
31427180-7	2020	The 7-ketocholesterol (7-kchol) levels in DM1 and DM2 patients exceeded these values in healthy individuals by 2.5 and 5-fold, respectively.	7-ketocholesterol	4-21	immunoglobulin heavy diversity 1-7	Homo sapiens	42-45
31427180-7	2020	The 7-ketocholesterol (7-kchol) levels in DM1 and DM2 patients exceeded these values in healthy individuals by 2.5 and 5-fold, respectively.	7-ketocholesterol	4-21	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	50-53
31427180-7	2020	The 7-ketocholesterol (7-kchol) levels in DM1 and DM2 patients exceeded these values in healthy individuals by 2.5 and 5-fold, respectively.	7-ketocholesterol	23-30	immunoglobulin heavy diversity 1-7	Homo sapiens	42-45
31427180-7	2020	The 7-ketocholesterol (7-kchol) levels in DM1 and DM2 patients exceeded these values in healthy individuals by 2.5 and 5-fold, respectively.	7-ketocholesterol	23-30	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	50-53
31660692-6	2020	To further explore the mechanism of autophagy on macrophage apoptosis, we used macrophage apoptosis model in vitro and found that 7-ketocholesterol (7-KC, one of the primary oxysterols in oxLDL) caused macrophage apoptosis with concomitant impairment of mitochondria, characterized by the impairment of mitochondrial ultrastructure, cytochrome c release, mitochondrial potential dissipation, mitochondrial fragmentation, excessive ROS generation and both caspase-9 and caspase-3 activation.	7-ketocholesterol	130-147	caspase 9	Mus musculus	455-464
31660692-6	2020	To further explore the mechanism of autophagy on macrophage apoptosis, we used macrophage apoptosis model in vitro and found that 7-ketocholesterol (7-KC, one of the primary oxysterols in oxLDL) caused macrophage apoptosis with concomitant impairment of mitochondria, characterized by the impairment of mitochondrial ultrastructure, cytochrome c release, mitochondrial potential dissipation, mitochondrial fragmentation, excessive ROS generation and both caspase-9 and caspase-3 activation.	7-ketocholesterol	130-147	caspase 3	Mus musculus	469-478
31660692-6	2020	To further explore the mechanism of autophagy on macrophage apoptosis, we used macrophage apoptosis model in vitro and found that 7-ketocholesterol (7-KC, one of the primary oxysterols in oxLDL) caused macrophage apoptosis with concomitant impairment of mitochondria, characterized by the impairment of mitochondrial ultrastructure, cytochrome c release, mitochondrial potential dissipation, mitochondrial fragmentation, excessive ROS generation and both caspase-9 and caspase-3 activation.	7-ketocholesterol	149-153	caspase 9	Mus musculus	455-464
31660692-6	2020	To further explore the mechanism of autophagy on macrophage apoptosis, we used macrophage apoptosis model in vitro and found that 7-ketocholesterol (7-KC, one of the primary oxysterols in oxLDL) caused macrophage apoptosis with concomitant impairment of mitochondria, characterized by the impairment of mitochondrial ultrastructure, cytochrome c release, mitochondrial potential dissipation, mitochondrial fragmentation, excessive ROS generation and both caspase-9 and caspase-3 activation.	7-ketocholesterol	149-153	caspase 3	Mus musculus	469-478
30801716-4	2019	An in vitro human simulated gastrointestinal digestion in the presence of cholesterol or its main dietary oxidized derivative, 7-ketocholesterol, showed that OCE-fortified pasta strongly reduced the bioaccessibility of both the sterols (the higher the incorporated OCE level, the higher the effect).	7-ketocholesterol	127-144	solute carrier family 45 member 1	Homo sapiens	172-177
30563252-0	2018	Evaluation of Antioxidant, Anti-Inflammatory and Cytoprotective Properties of Ethanolic Mint Extracts from Algeria on 7-Ketocholesterol-Treated Murine RAW 264.7 Macrophages.	7-ketocholesterol	118-135	amyloid beta (A4) precursor protein binding, family A, member 1	Mus musculus	88-92
30063760-4	2018	7-Ketocholesterol enhanced the expression of E-selectin, ICAM-1, and VCAM-1 proteins.	7-ketocholesterol	0-17	selectin E	Homo sapiens	45-55
30063760-4	2018	7-Ketocholesterol enhanced the expression of E-selectin, ICAM-1, and VCAM-1 proteins.	7-ketocholesterol	0-17	intercellular adhesion molecule 1	Homo sapiens	57-63
30063760-4	2018	7-Ketocholesterol enhanced the expression of E-selectin, ICAM-1, and VCAM-1 proteins.	7-ketocholesterol	0-17	vascular cell adhesion molecule 1	Homo sapiens	69-75
30063760-5	2018	It also activated p38 mitogen-activated protein kinase (MAPK), and treatment with a p38 MAPK inhibitor inhibited both E-selectin expression via ATF-2 activation and 7-ketocholesterol-induced THP-1 adhesion to HUVECs.	7-ketocholesterol	165-182	GLI family zinc finger 2	Homo sapiens	191-196
29154978-0	2018	7-Ketocholesterol induces ROS-mediated mRNA expression of 12-lipoxygenase, cyclooxygenase-2 and pro-inflammatory cytokines in human mesangial cells: Potential role in diabetic nephropathy.	7-ketocholesterol	0-17	prostaglandin-endoperoxide synthase 2	Homo sapiens	75-91
29475132-6	2018	In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes.	7-ketocholesterol	138-155	NLR family, pyrin domain containing 3	Mus musculus	107-112
29475132-6	2018	In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes.	7-ketocholesterol	157-162	NLR family, pyrin domain containing 3	Mus musculus	107-112
29475132-6	2018	In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes.	7-ketocholesterol	273-278	NLR family, pyrin domain containing 3	Mus musculus	107-112
29197565-4	2018	Lately, two metabolites that are markedly increased in NP-C patients are arising as biomarkers for this disease screening: 7-ketocholesterol and cholestane-3beta,5alpha,6beta-triol, both oxidized cholesterol products.	7-ketocholesterol	123-140	NPC intracellular cholesterol transporter 1	Homo sapiens	55-59
29449331-9	2018	Both 7-ketocholesterol and 27-hydroxycholesterol increased tissue factor expression in cultured rat vascular smooth muscle cells.	7-ketocholesterol	5-22	coagulation factor III, tissue factor	Rattus norvegicus	59-72
29227331-4	2018	Four inborn errors of metabolism, Smith-Lemli-Opitz syndrome, cerebrotendinous xanthomatosis and Niemann Pick disease types B (NPB) and C (NPC) result from mutations in different genes but can generate elevated levels of the same sterol metabolite, 7-oxocholesterol, in plasma.	7-ketocholesterol	249-265	neuropeptide B	Homo sapiens	127-130
29581835-0	2018	Cell internalization of 7-ketocholesterol-containing nanoemulsion through LDL receptor reduces melanoma growth in vitro and in vivo: a preliminary report.	7-ketocholesterol	24-41	low density lipoprotein receptor	Mus musculus	74-86
29331507-9	2018	The ROR inverse agonists SR1001 and the 7-oxygenated sterols 7-beta-hydroxysterol and 7-ketocholesterol, or the Rev-erb agonist SR9009, suppress ENHO expression in cultured human HepG2 cells.	7-ketocholesterol	86-103	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	4-7
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	14-31	NLR family, pyrin domain containing 3	Mus musculus	121-126
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	14-31	NLR family, pyrin domain containing 3	Mus musculus	234-239
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	14-31	steroid sulfatase	Mus musculus	245-248
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	14-31	caspase 1	Mus musculus	252-261
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	14-31	caspase 1	Mus musculus	272-281
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	14-31	interleukin 1 beta	Mus musculus	304-312
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	14-31	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	361-364
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	14-31	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	372-375
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	14-31	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	424-427
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	33-39	NLR family, pyrin domain containing 3	Mus musculus	121-126
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	33-39	NLR family, pyrin domain containing 3	Mus musculus	234-239
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	33-39	steroid sulfatase	Mus musculus	245-248
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	33-39	caspase 1	Mus musculus	252-261
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	33-39	caspase 1	Mus musculus	272-281
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	33-39	interleukin 1 beta	Mus musculus	304-312
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	33-39	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	361-364
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	33-39	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	372-375
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	33-39	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	424-427
28119977-0	2017	Anti-inflammatory activity of 3beta-hydroxycholest-5-en-7-one isolated from Hippocampus trimaculatus leach via inhibiting iNOS, TNF-alpha, and 1L-1beta of LPS induced RAW 264.7 macrophage cells.	7-ketocholesterol	30-61	nitric oxide synthase 2, inducible	Mus musculus	122-126
28710022-2	2017	7-ketocholesterol induced phosphorylation of Akt, and increase in the levels of cytosolic and nuclear NF-kappaB p65, cytosolic NF-kappaB p50 and cytosolic phosphorylated-IkappaB-alpha in PC12 cells.	7-ketocholesterol	0-17	AKT serine/threonine kinase 1	Homo sapiens	45-48
28710022-2	2017	7-ketocholesterol induced phosphorylation of Akt, and increase in the levels of cytosolic and nuclear NF-kappaB p65, cytosolic NF-kappaB p50 and cytosolic phosphorylated-IkappaB-alpha in PC12 cells.	7-ketocholesterol	0-17	nuclear factor kappa B subunit 1	Homo sapiens	102-111
28710022-2	2017	7-ketocholesterol induced phosphorylation of Akt, and increase in the levels of cytosolic and nuclear NF-kappaB p65, cytosolic NF-kappaB p50 and cytosolic phosphorylated-IkappaB-alpha in PC12 cells.	7-ketocholesterol	0-17	RELA proto-oncogene, NF-kB subunit	Homo sapiens	112-115
28710022-2	2017	7-ketocholesterol induced phosphorylation of Akt, and increase in the levels of cytosolic and nuclear NF-kappaB p65, cytosolic NF-kappaB p50 and cytosolic phosphorylated-IkappaB-alpha in PC12 cells.	7-ketocholesterol	0-17	nuclear factor kappa B subunit 1	Homo sapiens	127-140
27341688-4	2017	The results showed that oxLDL induced in THP-1 macrophages: (i) increase of MMP-9 gene expression and its pro-form secretion, (ii) intracellular accumulation of 7-ketocholesterol, (iii) ERS activation (increased eIF2alpha phosphorylation, XBP1 and CHOP mRNA levels, and Grp78 protein expression), and (iv) oxidative stress (increased levels of reactive oxygen species and NADPH oxidase activity).	7-ketocholesterol	161-178	GLI family zinc finger 2	Homo sapiens	41-46
28350877-5	2017	Human THP-1 macrophages were exposed to an atheroma-relevant mixture of 7beta-hydroxycholesterol and 7-ketocholesterol.	7-ketocholesterol	101-118	GLI family zinc finger 2	Homo sapiens	6-11
29029490-0	2017	7-ketocholesterol and 27-hydroxycholesterol decreased doxorubicin sensitivity in breast cancer cells: estrogenic activity and mTOR pathway.	7-ketocholesterol	0-17	mechanistic target of rapamycin kinase	Homo sapiens	126-130
29029490-3	2017	When cells were exposed to oxysterols in fetal bovine serum-supplemented medium, 7-ketocholesterol (7-KC), but not 27-hydroxycholesterol (27-HC), decreased the cytotoxicity of doxorubicin in MCF-7 (high estrogen receptor (ER)alpha/ERbeta ratio) cells and the decreased cytotoxicity was restored by the P-glycoprotein inhibitor verapamil.	7-ketocholesterol	81-98	estrogen receptor 2	Homo sapiens	231-237
28119977-0	2017	Anti-inflammatory activity of 3beta-hydroxycholest-5-en-7-one isolated from Hippocampus trimaculatus leach via inhibiting iNOS, TNF-alpha, and 1L-1beta of LPS induced RAW 264.7 macrophage cells.	7-ketocholesterol	30-61	tumor necrosis factor	Mus musculus	128-137
27740938-0	2016	7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells.	7-ketocholesterol	0-17	checkpoint kinase 1	Homo sapiens	35-39
28208647-3	2017	ESL induced the expression of Kruppel-like factor 2 (KLF2), an endothelial transcription factor, and endothelial nitric oxide synthase (eNOS), and suppressed the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) through moderate inflammatory signal activation, not only in tumor necrosis factor-alpha (TNF-alpha)-stimulated HUVECs but also in 7-ketocholesterol (7-KC)-stimulated HUVECs.	7-ketocholesterol	397-414	vascular cell adhesion molecule 1	Mus musculus	211-217
28116245-0	2017	7-ketocholesterol induces apoptosis of MC3T3-E1 cells associated with reactive oxygen species generation, endoplasmic reticulum stress and caspase-3/7 dependent pathway.	7-ketocholesterol	0-17	caspase 3	Mus musculus	139-148
27740938-0	2016	7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells.	7-ketocholesterol	0-17	ATM serine/threonine kinase	Homo sapiens	26-29
27740938-0	2016	7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells.	7-ketocholesterol	0-17	checkpoint kinase 2	Homo sapiens	40-44
27740938-0	2016	7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells.	7-ketocholesterol	0-17	AKT serine/threonine kinase 1	Homo sapiens	51-54
27740938-0	2016	7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells.	7-ketocholesterol	0-17	ATR serine/threonine kinase	Homo sapiens	30-33
27740938-0	2016	7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells.	7-ketocholesterol	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
26239048-2	2015	Recent studies have shown that plasma cholestane-3beta,5alpha,6beta-triol (CT) and 7-ketocholesterol (7-KC) could be potential biomarkers for the diagnosis of NPC patients.	7-ketocholesterol	83-100	NPC intracellular cholesterol transporter 1	Homo sapiens	159-162
27109381-8	2016	This activation was dependent on pannexin-1 with 25-hydroxycholesterol whereas P2X7 receptor signaling pathway was pannexin-1-independent for 7-ketocholesterol.	7-ketocholesterol	142-159	purinergic receptor P2X 7	Homo sapiens	79-92
26992564-5	2016	ORP2 silencing also increases cellular cholesterol, concomitant with decreased amounts of 22-hydroxycholesterol and 7-ketocholesterol, two molecules that have been shown to bind to ORP2.	7-ketocholesterol	116-133	oxysterol binding protein like 2	Homo sapiens	0-4
26992564-5	2016	ORP2 silencing also increases cellular cholesterol, concomitant with decreased amounts of 22-hydroxycholesterol and 7-ketocholesterol, two molecules that have been shown to bind to ORP2.	7-ketocholesterol	116-133	oxysterol binding protein like 2	Homo sapiens	181-185
26733147-4	2016	As expected, NP-C patients showed significant increase of both C-triol and 7-KC.	7-ketocholesterol	75-79	NPC intracellular cholesterol transporter 1	Homo sapiens	13-17
26709800-3	2016	In primary cultured CASMCs, lysosomal Ca2+ induced by 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer) was markedly attenuated by ASM deficiency or TRPML1 gene silencing suggesting that ASM signaling is required for TRPML1 channel activity and subsequent lysosomal Ca(2+) release.	7-ketocholesterol	54-71	mucolipin TRP cation channel 1	Homo sapiens	172-178
26709800-3	2016	In primary cultured CASMCs, lysosomal Ca2+ induced by 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer) was markedly attenuated by ASM deficiency or TRPML1 gene silencing suggesting that ASM signaling is required for TRPML1 channel activity and subsequent lysosomal Ca(2+) release.	7-ketocholesterol	54-71	sphingomyelin phosphodiesterase 1	Homo sapiens	21-24
26709800-3	2016	In primary cultured CASMCs, lysosomal Ca2+ induced by 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer) was markedly attenuated by ASM deficiency or TRPML1 gene silencing suggesting that ASM signaling is required for TRPML1 channel activity and subsequent lysosomal Ca(2+) release.	7-ketocholesterol	54-71	mucolipin TRP cation channel 1	Homo sapiens	240-246
26709800-3	2016	In primary cultured CASMCs, lysosomal Ca2+ induced by 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer) was markedly attenuated by ASM deficiency or TRPML1 gene silencing suggesting that ASM signaling is required for TRPML1 channel activity and subsequent lysosomal Ca(2+) release.	7-ketocholesterol	73-78	mucolipin TRP cation channel 1	Homo sapiens	172-178
26709800-3	2016	In primary cultured CASMCs, lysosomal Ca2+ induced by 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer) was markedly attenuated by ASM deficiency or TRPML1 gene silencing suggesting that ASM signaling is required for TRPML1 channel activity and subsequent lysosomal Ca(2+) release.	7-ketocholesterol	73-78	mucolipin TRP cation channel 1	Homo sapiens	240-246
26709800-4	2016	In these CASMCs, ASM deficiency or TRPML1 gene silencing markedly inhibited 7-Ket-induced dynein activation.	7-ketocholesterol	76-81	mucolipin TRP cation channel 1	Homo sapiens	35-41
26709800-5	2016	In addition, 7-Ket-induced autophagosome trafficking, an event associated with lysosomal Ca(2+) release and dynein activity, was significantly inhibited in ASM-deficient (Smpd1(-/-)) CASMCs compared to that in Smpd1(+/+) CASMCs.	7-ketocholesterol	13-18	sphingomyelin phosphodiesterase 1	Homo sapiens	171-176
26709800-5	2016	In addition, 7-Ket-induced autophagosome trafficking, an event associated with lysosomal Ca(2+) release and dynein activity, was significantly inhibited in ASM-deficient (Smpd1(-/-)) CASMCs compared to that in Smpd1(+/+) CASMCs.	7-ketocholesterol	13-18	sphingomyelin phosphodiesterase 1	Homo sapiens	210-215
27256227-1	2016	OBJECTIVE: To investigate 7-ketocholesterol (7-KC) level in the blood, clinical features and gene mutation of Niemann-Pick disease type C (NPC).	7-ketocholesterol	26-43	NPC intracellular cholesterol transporter 1	Homo sapiens	110-137
27256227-1	2016	OBJECTIVE: To investigate 7-ketocholesterol (7-KC) level in the blood, clinical features and gene mutation of Niemann-Pick disease type C (NPC).	7-ketocholesterol	26-43	NPC intracellular cholesterol transporter 1	Homo sapiens	139-142
25845326-3	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in the levels of BH3 interacting-domain death agonist (Bid) and B cell lymphoma 2 (Bcl-2), increase in the levels of Bcl-2-associated X protein (Bax) and p53, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases, and cleavage of poly(ADP-ribose) polymerase 1 (PARP-1).	7-ketocholesterol	0-17	BH3 interacting domain death agonist	Rattus norvegicus	118-121
26122972-4	2015	7-Ketocholesterol and 25-hydroxycholesterol decreased the levels of Bid and Bcl-2, increased the levels of Bax and p53, and induced loss of the mitochondrial transmembrane potential, release of cytochrome c and activation of caspases (-8, -9 and -3).	7-ketocholesterol	0-17	BH3 interacting domain death agonist	Rattus norvegicus	68-71
26122972-4	2015	7-Ketocholesterol and 25-hydroxycholesterol decreased the levels of Bid and Bcl-2, increased the levels of Bax and p53, and induced loss of the mitochondrial transmembrane potential, release of cytochrome c and activation of caspases (-8, -9 and -3).	7-ketocholesterol	0-17	BCL2, apoptosis regulator	Rattus norvegicus	76-81
26122972-4	2015	7-Ketocholesterol and 25-hydroxycholesterol decreased the levels of Bid and Bcl-2, increased the levels of Bax and p53, and induced loss of the mitochondrial transmembrane potential, release of cytochrome c and activation of caspases (-8, -9 and -3).	7-ketocholesterol	0-17	BCL2 associated X, apoptosis regulator	Rattus norvegicus	107-110
26122972-4	2015	7-Ketocholesterol and 25-hydroxycholesterol decreased the levels of Bid and Bcl-2, increased the levels of Bax and p53, and induced loss of the mitochondrial transmembrane potential, release of cytochrome c and activation of caspases (-8, -9 and -3).	7-ketocholesterol	0-17	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	115-118
26122972-4	2015	7-Ketocholesterol and 25-hydroxycholesterol decreased the levels of Bid and Bcl-2, increased the levels of Bax and p53, and induced loss of the mitochondrial transmembrane potential, release of cytochrome c and activation of caspases (-8, -9 and -3).	7-ketocholesterol	0-17	caspase 8	Rattus norvegicus	225-248
25845326-4	2015	7-Ketocholesterol induced increase in cytosolic and nuclear NF-kappaB p65, nuclear phospho-NF-kappaB p65, cytosolic NF-kappaB p50, and cytosolic phospho-IkappaB-alpha levels.	7-ketocholesterol	0-17	synaptotagmin 1	Rattus norvegicus	70-73
25845326-4	2015	7-Ketocholesterol induced increase in cytosolic and nuclear NF-kappaB p65, nuclear phospho-NF-kappaB p65, cytosolic NF-kappaB p50, and cytosolic phospho-IkappaB-alpha levels.	7-ketocholesterol	0-17	synaptotagmin 1	Rattus norvegicus	101-104
26122972-5	2015	7-Ketocholesterol caused an increase in the levels of cytosolic and nuclear NF-kappaB p65, cytosolic NF-kappaB p50 and cytosolic phospho-IkappaB-alpha, which was inhibited by the addition of 0.5 muM Bay11-7085 (an inhibitor of NF-kappaB activation).	7-ketocholesterol	0-17	synaptotagmin 1	Rattus norvegicus	86-89
25845326-3	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in the levels of BH3 interacting-domain death agonist (Bid) and B cell lymphoma 2 (Bcl-2), increase in the levels of Bcl-2-associated X protein (Bax) and p53, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases, and cleavage of poly(ADP-ribose) polymerase 1 (PARP-1).	7-ketocholesterol	0-17	BCL2, apoptosis regulator	Rattus norvegicus	127-144
25845326-3	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in the levels of BH3 interacting-domain death agonist (Bid) and B cell lymphoma 2 (Bcl-2), increase in the levels of Bcl-2-associated X protein (Bax) and p53, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases, and cleavage of poly(ADP-ribose) polymerase 1 (PARP-1).	7-ketocholesterol	0-17	BCL2, apoptosis regulator	Rattus norvegicus	146-151
25845326-3	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in the levels of BH3 interacting-domain death agonist (Bid) and B cell lymphoma 2 (Bcl-2), increase in the levels of Bcl-2-associated X protein (Bax) and p53, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases, and cleavage of poly(ADP-ribose) polymerase 1 (PARP-1).	7-ketocholesterol	0-17	BCL2 associated X, apoptosis regulator	Rattus norvegicus	180-206
25845326-3	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in the levels of BH3 interacting-domain death agonist (Bid) and B cell lymphoma 2 (Bcl-2), increase in the levels of Bcl-2-associated X protein (Bax) and p53, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases, and cleavage of poly(ADP-ribose) polymerase 1 (PARP-1).	7-ketocholesterol	0-17	BCL2 associated X, apoptosis regulator	Rattus norvegicus	208-211
25845326-3	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in the levels of BH3 interacting-domain death agonist (Bid) and B cell lymphoma 2 (Bcl-2), increase in the levels of Bcl-2-associated X protein (Bax) and p53, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases, and cleavage of poly(ADP-ribose) polymerase 1 (PARP-1).	7-ketocholesterol	0-17	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	217-220
25845326-3	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in the levels of BH3 interacting-domain death agonist (Bid) and B cell lymphoma 2 (Bcl-2), increase in the levels of Bcl-2-associated X protein (Bax) and p53, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases, and cleavage of poly(ADP-ribose) polymerase 1 (PARP-1).	7-ketocholesterol	0-17	caspase 8	Rattus norvegicus	309-317
25845326-3	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in the levels of BH3 interacting-domain death agonist (Bid) and B cell lymphoma 2 (Bcl-2), increase in the levels of Bcl-2-associated X protein (Bax) and p53, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases, and cleavage of poly(ADP-ribose) polymerase 1 (PARP-1).	7-ketocholesterol	0-17	poly (ADP-ribose) polymerase 1	Rattus norvegicus	335-364
25845326-3	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in the levels of BH3 interacting-domain death agonist (Bid) and B cell lymphoma 2 (Bcl-2), increase in the levels of Bcl-2-associated X protein (Bax) and p53, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases, and cleavage of poly(ADP-ribose) polymerase 1 (PARP-1).	7-ketocholesterol	0-17	poly (ADP-ribose) polymerase 1	Rattus norvegicus	366-372
25576871-0	2015	7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels.	7-ketocholesterol	0-17	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	43-49
25697053-7	2015	Our data provide evidence that 7-ketocholesterol and 5,6-secosterol are efficient instigators of apoptosis, which for 5,6-secosterol is associated to PKC and p53 up-regulation.	7-ketocholesterol	31-48	tumor protein p53	Homo sapiens	158-161
25617738-0	2015	Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2alpha and SOAT1 followed by selective efflux to HDL.	7-ketocholesterol	28-45	phospholipase A2 group IVA	Homo sapiens	90-100
25617738-0	2015	Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2alpha and SOAT1 followed by selective efflux to HDL.	7-ketocholesterol	28-45	sterol O-acyltransferase 1	Homo sapiens	105-110
25592323-4	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in Bid, Bcl-2, Bcl-xL and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), cleavage of PARP-1 and an increase in the tumor suppressor p53 levels.	7-ketocholesterol	0-17	BH3 interacting domain death agonist	Rattus norvegicus	66-69
25592323-4	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in Bid, Bcl-2, Bcl-xL and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), cleavage of PARP-1 and an increase in the tumor suppressor p53 levels.	7-ketocholesterol	0-17	BCL2, apoptosis regulator	Rattus norvegicus	71-76
25592323-4	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in Bid, Bcl-2, Bcl-xL and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), cleavage of PARP-1 and an increase in the tumor suppressor p53 levels.	7-ketocholesterol	0-17	Bcl2-like 1	Rattus norvegicus	78-84
25592323-4	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in Bid, Bcl-2, Bcl-xL and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), cleavage of PARP-1 and an increase in the tumor suppressor p53 levels.	7-ketocholesterol	0-17	BCL2 associated X, apoptosis regulator	Rattus norvegicus	126-129
25592323-4	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in Bid, Bcl-2, Bcl-xL and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), cleavage of PARP-1 and an increase in the tumor suppressor p53 levels.	7-ketocholesterol	0-17	poly (ADP-ribose) polymerase 1	Rattus norvegicus	263-269
25592323-4	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in Bid, Bcl-2, Bcl-xL and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), cleavage of PARP-1 and an increase in the tumor suppressor p53 levels.	7-ketocholesterol	0-17	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	310-313
26315049-14	2015	CONCLUSION: Taken together, these results suggest that CD38 activity is required for 7-Ket-induced Ca2+ and consequently O2-.	7-ketocholesterol	85-90	CD38 antigen	Mus musculus	55-59
25678688-0	2015	Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1beta and IL-18.	7-ketocholesterol	25-42	interleukin 1 beta	Homo sapiens	140-148
25678688-0	2015	Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1beta and IL-18.	7-ketocholesterol	25-42	interleukin 18	Homo sapiens	153-158
26315049-5	2015	This phenotypic change in CD38-/- CAMs was enhanced by 7-ketocholesterol (7-Ket), an atherogenic stimulus.	7-ketocholesterol	55-72	CD38 antigen	Mus musculus	26-30
26315049-5	2015	This phenotypic change in CD38-/- CAMs was enhanced by 7-ketocholesterol (7-Ket), an atherogenic stimulus.	7-ketocholesterol	74-79	CD38 antigen	Mus musculus	26-30
26315049-7	2015	Similar to CD38 deletion, Nrf2 gene silencing increased CAM dedifferentiation upon 7-Ket stimulation.	7-ketocholesterol	83-88	nuclear factor, erythroid derived 2, like 2	Mus musculus	26-30
26315049-8	2015	In contrast, the overexpression of Nrf2 gene abolished 7-Ket-induced dedifferentiation in CD38-/- CAMs.	7-ketocholesterol	55-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	35-39
26315049-8	2015	In contrast, the overexpression of Nrf2 gene abolished 7-Ket-induced dedifferentiation in CD38-/- CAMs.	7-ketocholesterol	55-60	CD38 antigen	Mus musculus	90-94
26315049-10	2015	It was demonstrated that in CD38-/- CAMs, 7-Ket failed to stimulate the production of O2-., while in CD38+/+ CAMs 7-Ket induced marked O2-.	7-ketocholesterol	114-119	CD38 antigen	Mus musculus	101-105
24642088-3	2014	The purpose of this study was to determine the effects and mechanisms of 7-ketocholesterol (7-KC) on isocitrate dehydrogenase 2 (IDH2) and its impact on endothelial function in both human aortic endothelial cells (HAECs) and C57BL/6J mice.	7-ketocholesterol	73-90	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	129-133
25131929-5	2014	7-Ketocholesterol, an oxidized derivative of cholesterol, majorly enhanced the fluidity of and Abeta interaction with Ld phase.	7-ketocholesterol	0-17	amyloid beta precursor protein	Homo sapiens	95-100
24927729-4	2014	The structure-based mutation T104L in the B" helix, corresponding to the nonpolar residue of CYP7B1, was used to obtain crystals of complexes with cholest-4-en-3-one and with cholesterol oxidation product 7-ketocholesterol (7KCh).	7-ketocholesterol	205-222	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	93-99
25036103-0	2014	7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo.	7-ketocholesterol	0-17	toll like receptor 4	Homo sapiens	66-70
24727230-4	2014	The aim of the study was to analyze the effect of 7-ketocholesterol on the barrier functions and IL-10 mRNA expression of Caco-2 cells in the presence of DCs, and secondly, on IL-10 mRNA expression in DCs.	7-ketocholesterol	50-67	interleukin 10	Homo sapiens	97-102
24727230-7	2014	7-ketocholesterol decreased the TER of Caco-2 cells co-cultured with DCs and diminished IL-10 mRNA expression in Caco-2 cells induced by the presence of DCs.	7-ketocholesterol	0-17	interleukin 10	Homo sapiens	88-93
24727230-8	2014	IL-10 mRNA expression fell in DCs co-cultured with Caco-2 cells after treatment with 7-ketocholesterol.	7-ketocholesterol	85-102	interleukin 10	Homo sapiens	0-5
24642088-3	2014	The purpose of this study was to determine the effects and mechanisms of 7-ketocholesterol (7-KC) on isocitrate dehydrogenase 2 (IDH2) and its impact on endothelial function in both human aortic endothelial cells (HAECs) and C57BL/6J mice.	7-ketocholesterol	92-96	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	129-133
24642088-4	2014	HAECs treated with 7-KC showed significant reductions of IDH2 mRNA and protein levels and enzyme activity, leading to decreased NADPH concentration and an increased ratio of reduced-to-oxidized glutathione in the mitochondria.	7-ketocholesterol	19-23	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	57-61
24642088-11	2014	Infusion of 7-KC in vivo decreased vascular IDH2 expression and impaired vascular reactivity via miR-144.	7-ketocholesterol	12-16	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	44-48
24642088-11	2014	Infusion of 7-KC in vivo decreased vascular IDH2 expression and impaired vascular reactivity via miR-144.	7-ketocholesterol	12-16	microRNA 144	Homo sapiens	97-104
24445604-8	2014	Mechanistically, CD38 gene deletion markedly inhibited 7-Ket-induced dynein activation and autophagosome trafficking, which were associated with attenuated lysosomal Ca(2+) release.	7-ketocholesterol	55-60	CD38 antigen	Mus musculus	17-21
24463558-4	2014	By Western blotting and flow cytometry, atherogenic stimulation of Smpd1+/+ CASMCs with 7-ketocholesterol was found to significantly enhance LC3B expression and increase the content of both APs and autophagolysosomes (APLs).	7-ketocholesterol	88-105	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	67-72
24463558-4	2014	By Western blotting and flow cytometry, atherogenic stimulation of Smpd1+/+ CASMCs with 7-ketocholesterol was found to significantly enhance LC3B expression and increase the content of both APs and autophagolysosomes (APLs).	7-ketocholesterol	88-105	microtubule-associated protein 1 light chain 3 beta	Mus musculus	141-145
24463558-5	2014	In Smpd1-/- CASMCs, such 7-ketocholesterol-induced increases in LC3B and p62 expression and APs were further augmented, but APLs formation was abolished.	7-ketocholesterol	25-42	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	3-8
24463558-5	2014	In Smpd1-/- CASMCs, such 7-ketocholesterol-induced increases in LC3B and p62 expression and APs were further augmented, but APLs formation was abolished.	7-ketocholesterol	25-42	microtubule-associated protein 1 light chain 3 beta	Mus musculus	64-68
24463558-5	2014	In Smpd1-/- CASMCs, such 7-ketocholesterol-induced increases in LC3B and p62 expression and APs were further augmented, but APLs formation was abolished.	7-ketocholesterol	25-42	nucleoporin 62	Mus musculus	73-76
24463558-6	2014	Analysis of fluorescence resonance energy transfer between fluorescence-labeled LC3B and Lamp1 (lysosome marker) showed that 7-ketocholesterol markedly induced fusion of APs with lysosomes in Smpd1+/+ CASMCs, which was abolished in Smpd1-/- CASMCs.	7-ketocholesterol	125-142	microtubule-associated protein 1 light chain 3 beta	Mus musculus	80-84
24463558-6	2014	Analysis of fluorescence resonance energy transfer between fluorescence-labeled LC3B and Lamp1 (lysosome marker) showed that 7-ketocholesterol markedly induced fusion of APs with lysosomes in Smpd1+/+ CASMCs, which was abolished in Smpd1-/- CASMCs.	7-ketocholesterol	125-142	lysosomal-associated membrane protein 1	Mus musculus	89-94
24463558-6	2014	Analysis of fluorescence resonance energy transfer between fluorescence-labeled LC3B and Lamp1 (lysosome marker) showed that 7-ketocholesterol markedly induced fusion of APs with lysosomes in Smpd1+/+ CASMCs, which was abolished in Smpd1-/- CASMCs.	7-ketocholesterol	125-142	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	192-197
24463558-6	2014	Analysis of fluorescence resonance energy transfer between fluorescence-labeled LC3B and Lamp1 (lysosome marker) showed that 7-ketocholesterol markedly induced fusion of APs with lysosomes in Smpd1+/+ CASMCs, which was abolished in Smpd1-/- CASMCs.	7-ketocholesterol	125-142	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	232-237
24463558-7	2014	Moreover, 7-ketocholesterol-induced expression of cell dedifferentiation marker vimentin and proliferation was enhanced in Smpd1-/- CASMCs compared with those in Smpd1+/+ CASMCs.	7-ketocholesterol	10-27	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	123-128
24463558-7	2014	Moreover, 7-ketocholesterol-induced expression of cell dedifferentiation marker vimentin and proliferation was enhanced in Smpd1-/- CASMCs compared with those in Smpd1+/+ CASMCs.	7-ketocholesterol	10-27	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	162-167
24445604-5	2014	In primary cultured CAMs, CD38 gene deletion markedly enhanced 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer)-induced accumulation of autophagosomes and increased expression of an autophagic marker, LC3B.	7-ketocholesterol	63-80	CD38 antigen	Mus musculus	26-30
24445604-5	2014	In primary cultured CAMs, CD38 gene deletion markedly enhanced 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer)-induced accumulation of autophagosomes and increased expression of an autophagic marker, LC3B.	7-ketocholesterol	63-80	microtubule-associated protein 1 light chain 3 beta	Mus musculus	225-229
24445604-5	2014	In primary cultured CAMs, CD38 gene deletion markedly enhanced 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer)-induced accumulation of autophagosomes and increased expression of an autophagic marker, LC3B.	7-ketocholesterol	82-87	CD38 antigen	Mus musculus	26-30
24445604-7	2014	Further, 7-Ket-induced formation of autophagolysosomes was markedly attenuated in CD38(-/-) CAMs compared with CD38(+/+) CAMs.	7-ketocholesterol	9-14	CD38 antigen	Mus musculus	82-86
24445604-7	2014	Further, 7-Ket-induced formation of autophagolysosomes was markedly attenuated in CD38(-/-) CAMs compared with CD38(+/+) CAMs.	7-ketocholesterol	9-14	CD38 antigen	Mus musculus	111-115
24771866-0	2014	On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO.	7-ketocholesterol	20-37	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	81-84
24771866-1	2014	A new mechanism for formation of 7-ketocholesterol was recently described involving cytochrome P-450 (CYP)7A1-catalyzed conversion of 7-dehydrocholesterol into 7-ketocholesterol with cholesterol-7,8-epoxide as a side product.	7-ketocholesterol	33-50	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	84-109
24771866-1	2014	A new mechanism for formation of 7-ketocholesterol was recently described involving cytochrome P-450 (CYP)7A1-catalyzed conversion of 7-dehydrocholesterol into 7-ketocholesterol with cholesterol-7,8-epoxide as a side product.	7-ketocholesterol	160-177	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	84-109
24771866-5	2014	In accord with this hypothesis, two patients with CTX were found to have increased levels of 7-ketocholesterol and 7-dehydrocholesterol, as well as a significant level of cholesterol-7,8-epoxide.	7-ketocholesterol	93-110	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	50-53
24771866-7	2014	Downregulation of CYP7A1 activity by treatment with chenodeoxycholic acid reduced the levels of 7-ketocholesterol in parallel with decreased levels of 7-dehydrocholesterol and cholesterol-7,8-epoxide.	7-ketocholesterol	96-113	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	18-24
24320932-5	2013	A more detailed mutagenesis study revealed that mutation of Asn316 or Phe 320 to Ala significantly reduced cellular cholesterol and 7-ketocholesterol efflux conferred by ABCG1, whereas replacement of Pro317 or Asp319 with Ala had no detectable effect.	7-ketocholesterol	132-149	ATP binding cassette subfamily G member 1	Homo sapiens	170-175
24868894-0	2014	[The effect of 7-ketocholesterol on surface ICAM-1 and PECAM-1 expression in human aortic endothelial cells].	7-ketocholesterol	15-32	intercellular adhesion molecule 1	Homo sapiens	44-50
24868894-0	2014	[The effect of 7-ketocholesterol on surface ICAM-1 and PECAM-1 expression in human aortic endothelial cells].	7-ketocholesterol	15-32	platelet and endothelial cell adhesion molecule 1	Homo sapiens	55-62
24868894-4	2014	The aim of this study was to evaluate the influence of 7-KCH on the surface expression of adhesion molecules--intracellular adhesion molecule 1 (ICAM-1, CD 54) and .platelet endothelial cell adhesion molecule 1 (PECAM-1, CD31) on human aortic endothelial cells (HAECs).	7-ketocholesterol	55-60	intercellular adhesion molecule 1	Homo sapiens	99-143
24868894-4	2014	The aim of this study was to evaluate the influence of 7-KCH on the surface expression of adhesion molecules--intracellular adhesion molecule 1 (ICAM-1, CD 54) and .platelet endothelial cell adhesion molecule 1 (PECAM-1, CD31) on human aortic endothelial cells (HAECs).	7-ketocholesterol	55-60	intercellular adhesion molecule 1	Homo sapiens	145-151
24868894-4	2014	The aim of this study was to evaluate the influence of 7-KCH on the surface expression of adhesion molecules--intracellular adhesion molecule 1 (ICAM-1, CD 54) and .platelet endothelial cell adhesion molecule 1 (PECAM-1, CD31) on human aortic endothelial cells (HAECs).	7-ketocholesterol	55-60	intercellular adhesion molecule 1	Homo sapiens	153-158
24868894-4	2014	The aim of this study was to evaluate the influence of 7-KCH on the surface expression of adhesion molecules--intracellular adhesion molecule 1 (ICAM-1, CD 54) and .platelet endothelial cell adhesion molecule 1 (PECAM-1, CD31) on human aortic endothelial cells (HAECs).	7-ketocholesterol	55-60	platelet and endothelial cell adhesion molecule 1	Homo sapiens	165-210
24868894-4	2014	The aim of this study was to evaluate the influence of 7-KCH on the surface expression of adhesion molecules--intracellular adhesion molecule 1 (ICAM-1, CD 54) and .platelet endothelial cell adhesion molecule 1 (PECAM-1, CD31) on human aortic endothelial cells (HAECs).	7-ketocholesterol	55-60	platelet and endothelial cell adhesion molecule 1	Homo sapiens	221-225
24868894-5	2014	MATERIAL AND METHODS: After treatment with 7-KCH surface expression of adhesion molecules on HAEC was measured with antihuman CD31 and anti-human CD54 antibodies using flow cytometer.	7-ketocholesterol	43-48	platelet and endothelial cell adhesion molecule 1	Homo sapiens	126-130
24868894-5	2014	MATERIAL AND METHODS: After treatment with 7-KCH surface expression of adhesion molecules on HAEC was measured with antihuman CD31 and anti-human CD54 antibodies using flow cytometer.	7-ketocholesterol	43-48	intercellular adhesion molecule 1	Homo sapiens	146-150
24868894-6	2014	RESULTS: 7-KCH significantly increases percentages of CD 54 on viable HEAC, but does not affect expression of CD 31.	7-ketocholesterol	9-14	intercellular adhesion molecule 1	Homo sapiens	54-59
24868894-7	2014	CONCLUSION: 7-KCH may enhance the initiation of a local inflammatory response in atherosclerosis by increasing the expression of ICAM-1.	7-ketocholesterol	12-17	intercellular adhesion molecule 1	Homo sapiens	129-135
24398405-5	2014	Treatment with TBB inhibited the 7-ketocholesterol-induced decrease in Bid, Bcl-2 and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), cleavage of PARP-1, and increase in the tumor suppressor p53 levels.	7-ketocholesterol	33-50	BH3 interacting domain death agonist	Rattus norvegicus	71-74
24398405-5	2014	Treatment with TBB inhibited the 7-ketocholesterol-induced decrease in Bid, Bcl-2 and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), cleavage of PARP-1, and increase in the tumor suppressor p53 levels.	7-ketocholesterol	33-50	BCL2, apoptosis regulator	Rattus norvegicus	76-81
24398405-5	2014	Treatment with TBB inhibited the 7-ketocholesterol-induced decrease in Bid, Bcl-2 and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), cleavage of PARP-1, and increase in the tumor suppressor p53 levels.	7-ketocholesterol	33-50	BCL2 associated X, apoptosis regulator	Rattus norvegicus	123-126
24398405-5	2014	Treatment with TBB inhibited the 7-ketocholesterol-induced decrease in Bid, Bcl-2 and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), cleavage of PARP-1, and increase in the tumor suppressor p53 levels.	7-ketocholesterol	33-50	poly (ADP-ribose) polymerase 1	Rattus norvegicus	260-266
24398405-5	2014	Treatment with TBB inhibited the 7-ketocholesterol-induced decrease in Bid, Bcl-2 and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), cleavage of PARP-1, and increase in the tumor suppressor p53 levels.	7-ketocholesterol	33-50	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	305-308
24320932-8	2013	However, the efflux of cholesterol and 7-ketocholesterol was reduced in cells expressing ABCG1 mutant N316D, N316Q, or F320I compared with wild type ABCG1.	7-ketocholesterol	39-56	ATP binding cassette subfamily G member 1	Homo sapiens	89-94
24320932-8	2013	However, the efflux of cholesterol and 7-ketocholesterol was reduced in cells expressing ABCG1 mutant N316D, N316Q, or F320I compared with wild type ABCG1.	7-ketocholesterol	39-56	ATP binding cassette subfamily G member 1	Homo sapiens	149-154
23871021-7	2013	7-Ketocholesterol was the main COP in most cases during the whole heating treatment.	7-ketocholesterol	0-17	caspase recruitment domain family member 16	Homo sapiens	31-34
24095928-4	2013	Pharmacological or genetic inhibition of dynein activity dramatically enhanced 7-ketocholesterol (7-Ket)-induced expression of the autophagic marker LC3B and increased the cellular levels of p62, a selective substrate for autophagy.	7-ketocholesterol	79-96	microtubule-associated protein 1 light chain 3 beta	Mus musculus	149-153
24095928-4	2013	Pharmacological or genetic inhibition of dynein activity dramatically enhanced 7-ketocholesterol (7-Ket)-induced expression of the autophagic marker LC3B and increased the cellular levels of p62, a selective substrate for autophagy.	7-ketocholesterol	79-96	nucleoporin 62	Mus musculus	191-194
24095928-4	2013	Pharmacological or genetic inhibition of dynein activity dramatically enhanced 7-ketocholesterol (7-Ket)-induced expression of the autophagic marker LC3B and increased the cellular levels of p62, a selective substrate for autophagy.	7-ketocholesterol	98-103	microtubule-associated protein 1 light chain 3 beta	Mus musculus	149-153
24095928-4	2013	Pharmacological or genetic inhibition of dynein activity dramatically enhanced 7-ketocholesterol (7-Ket)-induced expression of the autophagic marker LC3B and increased the cellular levels of p62, a selective substrate for autophagy.	7-ketocholesterol	98-103	nucleoporin 62	Mus musculus	191-194
22999639-4	2013	In U937 cells, 7beta-hydroxycholesterol and 7-ketocholesterol induced production of reactive oxygen species (ROS), transient up-regulation of Egr1 followed by late induction of p53 and apoptosis.	7-ketocholesterol	44-61	early growth response 1	Homo sapiens	142-146
23792120-0	2013	7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells.	7-ketocholesterol	0-17	ATP binding cassette subfamily B member 1	Homo sapiens	26-40
23792120-0	2013	7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells.	7-ketocholesterol	0-17	mechanistic target of rapamycin kinase	Homo sapiens	54-58
23770348-0	2013	7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B.	7-ketocholesterol	0-17	NADPH oxidase 4	Homo sapiens	76-80
23770348-0	2013	7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B.	7-ketocholesterol	0-17	autophagy related 4B cysteine peptidase	Homo sapiens	85-90
23611834-0	2013	7-Oxo-cholesterol potentiates pro-inflammatory signaling in human M1 and M2 macrophages.	7-ketocholesterol	0-17	myoregulin	Homo sapiens	66-75
23611834-4	2013	We investigated whether 7-oxo-cholesterol (7oxo-C) affected polarized human M1 and M2 macrophage phenotypes and functions.	7-ketocholesterol	24-41	myoregulin	Homo sapiens	76-85
23611834-4	2013	We investigated whether 7-oxo-cholesterol (7oxo-C) affected polarized human M1 and M2 macrophage phenotypes and functions.	7-ketocholesterol	43-49	myoregulin	Homo sapiens	76-85
23611834-8	2013	Secretome profiling from cultured cell supernatants showed that 7oxo-C stimulated the production of key pro-atherogenic mediators involved in pro-inflammatory, pro-invasive and pro-angiogenic mechanisms both in M1 and M2 cells.	7-ketocholesterol	64-70	myoregulin	Homo sapiens	211-220
23611834-9	2013	Hypoxic conditions potentiated the effects of 7oxo-C on M1 and M2 cells.	7-ketocholesterol	46-52	myoregulin	Homo sapiens	56-65
22999639-4	2013	In U937 cells, 7beta-hydroxycholesterol and 7-ketocholesterol induced production of reactive oxygen species (ROS), transient up-regulation of Egr1 followed by late induction of p53 and apoptosis.	7-ketocholesterol	44-61	tumor protein p53	Homo sapiens	177-180
23826352-6	2013	Further analysis showed that rHDL containing the carboxyl-terminal deletion mutant apoA-I[Delta(185-243)] only slightly reduced (by 22%) the ABCG1-mediated efflux of 7-ketocholesterol, indicating that depending on the sterol type, structural changes in rHDL-associated apoA-I affect differently the ABCG1-mediated efflux of cholesterol and 7-ketocholesterol.	7-ketocholesterol	166-183	apolipoprotein A1	Homo sapiens	83-89
23826352-6	2013	Further analysis showed that rHDL containing the carboxyl-terminal deletion mutant apoA-I[Delta(185-243)] only slightly reduced (by 22%) the ABCG1-mediated efflux of 7-ketocholesterol, indicating that depending on the sterol type, structural changes in rHDL-associated apoA-I affect differently the ABCG1-mediated efflux of cholesterol and 7-ketocholesterol.	7-ketocholesterol	166-183	ATP binding cassette subfamily G member 1	Homo sapiens	141-146
23826352-6	2013	Further analysis showed that rHDL containing the carboxyl-terminal deletion mutant apoA-I[Delta(185-243)] only slightly reduced (by 22%) the ABCG1-mediated efflux of 7-ketocholesterol, indicating that depending on the sterol type, structural changes in rHDL-associated apoA-I affect differently the ABCG1-mediated efflux of cholesterol and 7-ketocholesterol.	7-ketocholesterol	340-357	apolipoprotein A1	Homo sapiens	83-89
23383297-7	2013	Aortic 7-ketocholesterol content was reduced 40% in 11betaHSD1-/-/apoE-/- mice vs. control.	7-ketocholesterol	7-24	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	52-62
23454145-7	2013	Cell-pre-incubation with bradykinin induced changes in ABCG expression levels after 7-ketostigmasterol-incubation; however, the energetic metabolism inhibition reduced NPC1L1 expression only in 7-ketocholesterol-incubated cells.	7-ketocholesterol	194-211	kininogen 1	Homo sapiens	25-35
23454145-7	2013	Cell-pre-incubation with bradykinin induced changes in ABCG expression levels after 7-ketostigmasterol-incubation; however, the energetic metabolism inhibition reduced NPC1L1 expression only in 7-ketocholesterol-incubated cells.	7-ketocholesterol	194-211	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	168-174
22940536-0	2013	11beta-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7beta-hydroxycholesterol.	7-ketocholesterol	148-165	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	0-42
22940536-2	2013	Inter-conversion of 7-KC and 7betaOHC has recently been shown as a novel role for the glucocorticoid-metabolizing enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).	7-ketocholesterol	20-24	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	121-163
22940536-2	2013	Inter-conversion of 7-KC and 7betaOHC has recently been shown as a novel role for the glucocorticoid-metabolizing enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).	7-ketocholesterol	20-24	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	165-176
23383297-7	2013	Aortic 7-ketocholesterol content was reduced 40% in 11betaHSD1-/-/apoE-/- mice vs. control.	7-ketocholesterol	7-24	apolipoprotein E	Mus musculus	66-70
22535762-5	2012	Mice fed C3G had greater expression of the ATP-binding cassette transporter G1 (ABCG1) and lower cholesterol, mainly 7-ketocholesterol (7-KC), concentrations than those fed the HCD.	7-ketocholesterol	117-134	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	9-12
22304296-7	2012	Genistein-mediated PON1 transactivation was partly inhibited by the oestrogen-receptor antagonist fulvestrant as well as by the aryl hydrocarbon receptor antagonist 7-ketocholesterol.	7-ketocholesterol	165-182	paraoxonase 1	Rattus norvegicus	19-23
22496390-10	2012	We find significant accumulation of three oxysterols, 7alpha-hydroxycholesterol, 7beta-hydroxycholesterol, and 7-ketocholesterol, in mouse aortas of dyslipidemic ApoE-/- mice at the early stage of atherosclerosis.	7-ketocholesterol	111-128	apolipoprotein E	Mus musculus	162-166
22870192-11	2012	Moreover, treatments with methyl-beta-cyclodextrin (MbetaCD) and 7-ketocholesterol (7KC) led to the dissociation between rafts and Na(V)1.8.	7-ketocholesterol	65-82	sodium voltage-gated channel alpha subunit 10	Homo sapiens	131-139
21987235-6	2012	No lipoperoxidation was observed following myeloperoxidase treatment; however, 7-ketocholesterol was detected indicating the products of myeloperoxidase interact with the surface of the LDL particles.	7-ketocholesterol	79-96	myeloperoxidase	Homo sapiens	137-152
21957962-0	2011	Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1.	7-ketocholesterol	72-89	ATP binding cassette subfamily A member 1	Homo sapiens	140-146
21957962-0	2011	Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1.	7-ketocholesterol	72-89	ATP binding cassette subfamily G member 1	Homo sapiens	151-157
21518695-3	2011	Recently, we demonstrated that two cholesterol oxidation products, specifically cholestane-3beta,5alpha,6beta-triol (3beta,5alpha,6beta-triol) and 7-ketocholesterol (7-KC), were markedly increased in the plasma of human NPC1 subjects, suggesting a role for these oxysterols in diagnosis of NPC1 disease and evaluation of therapeutics in clinical trials.	7-ketocholesterol	147-164	NPC intracellular cholesterol transporter 1	Homo sapiens	220-224
21575614-0	2011	alpha-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes.	7-ketocholesterol	25-42	caspase 3	Mus musculus	51-60
21575614-0	2011	alpha-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes.	7-ketocholesterol	25-42	glycogen synthase kinase 3 beta	Mus musculus	91-96
21575614-0	2011	alpha-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes.	7-ketocholesterol	25-42	myeloid cell leukemia sequence 1	Mus musculus	112-117
21575614-3	2011	On 158N murine oligodendrocytes treated with 7-ketocholesterol (20 mug/mL corresponding to 50 muM, 24-48 h), the induction of a mode of cell death by apoptosis characterised by the occurrence of cells with condensed and/or fragmented nuclei, caspase activation (including caspase-3) and internucleosomal DNA fragmentation was observed.	7-ketocholesterol	45-62	caspase 3	Mus musculus	272-281
21575614-5	2011	With alpha-tocopherol (400 muM), which was capable of counteracting 7-ketocholesterol-induced apoptosis, Akt and GSK3beta dephosphorylation were inhibited as well as Mcl-1 degradation.	7-ketocholesterol	68-85	thymoma viral proto-oncogene 1	Mus musculus	105-108
21575614-5	2011	With alpha-tocopherol (400 muM), which was capable of counteracting 7-ketocholesterol-induced apoptosis, Akt and GSK3beta dephosphorylation were inhibited as well as Mcl-1 degradation.	7-ketocholesterol	68-85	glycogen synthase kinase 3 beta	Mus musculus	113-121
21575614-5	2011	With alpha-tocopherol (400 muM), which was capable of counteracting 7-ketocholesterol-induced apoptosis, Akt and GSK3beta dephosphorylation were inhibited as well as Mcl-1 degradation.	7-ketocholesterol	68-85	myeloid cell leukemia sequence 1	Mus musculus	166-171
21575614-6	2011	These data underline that the potential protective effects of alpha-tocopherol against 7-ketocholesterol-induced apoptosis do not depend on the cell line considered, and that the cascade of events (Akt/GSK3beta/Mcl-1) constitutes a link between 7-ketocholesterol-induced cytoplasmic membrane dysfunctions and mitochondrial depolarisation leading to apoptosis.	7-ketocholesterol	245-262	thymoma viral proto-oncogene 1	Mus musculus	198-201
21813643-0	2011	Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate.	7-ketocholesterol	38-55	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	78-97
21813643-1	2011	7-Ketocholesterol is a bioactive sterol, a potent competitive inhibitor of cytochrome P450 7A1, and toxic in liver cells.	7-ketocholesterol	0-17	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	75-94
21498512-2	2011	Mitochondrial cytochrome P450 27A1 (CYP27A1) is a ubiquitous multifunctional sterol C27-hydroxylase that eliminates cholesterol and likely 7-ketocholesterol from the retina and many other tissues.	7-ketocholesterol	139-156	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	14-34
21411718-0	2011	Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells.	7-ketocholesterol	14-31	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	72-79
21498512-2	2011	Mitochondrial cytochrome P450 27A1 (CYP27A1) is a ubiquitous multifunctional sterol C27-hydroxylase that eliminates cholesterol and likely 7-ketocholesterol from the retina and many other tissues.	7-ketocholesterol	139-156	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	36-43
21035514-0	2011	7-ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-kappaB and Akt pathways.	7-ketocholesterol	0-17	AKT serine/threonine kinase 1	Rattus norvegicus	131-134
20573495-4	2011	Therefore, THP-1 macrophages were exposed to two different oxysterols, such as 7-keto-cholesterol (4-16 muM) and 25-hydroxycholesterol (2-4 muM), alone and in combination with lycopene (0.5-2 muM).	7-ketocholesterol	79-97	latexin	Homo sapiens	104-107
21035514-3	2011	We assessed the apoptotic effect of 7-ketocholesterol against differentiated PC12 cells in relation to activation of the reactive oxygen species-dependent nuclear factor (NF)-kappaB, which is mediated by the Akt pathway.	7-ketocholesterol	36-53	AKT serine/threonine kinase 1	Rattus norvegicus	208-211
21035514-4	2011	7-Ketocholesterol induced a decrease in cytosolic Bid and Bcl-2 levels, increase in cytosolic Bax levels, cytochrome c release, caspase-3 activation and upregulation of p53.	7-ketocholesterol	0-17	BH3 interacting domain death agonist	Rattus norvegicus	50-53
21035514-4	2011	7-Ketocholesterol induced a decrease in cytosolic Bid and Bcl-2 levels, increase in cytosolic Bax levels, cytochrome c release, caspase-3 activation and upregulation of p53.	7-ketocholesterol	0-17	BCL2, apoptosis regulator	Rattus norvegicus	58-63
21035514-4	2011	7-Ketocholesterol induced a decrease in cytosolic Bid and Bcl-2 levels, increase in cytosolic Bax levels, cytochrome c release, caspase-3 activation and upregulation of p53.	7-ketocholesterol	0-17	BCL2 associated X, apoptosis regulator	Rattus norvegicus	94-97
21035514-4	2011	7-Ketocholesterol induced a decrease in cytosolic Bid and Bcl-2 levels, increase in cytosolic Bax levels, cytochrome c release, caspase-3 activation and upregulation of p53.	7-ketocholesterol	0-17	caspase 3	Rattus norvegicus	128-137
21035514-4	2011	7-Ketocholesterol induced a decrease in cytosolic Bid and Bcl-2 levels, increase in cytosolic Bax levels, cytochrome c release, caspase-3 activation and upregulation of p53.	7-ketocholesterol	0-17	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	169-172
21035514-5	2011	7-Ketocholesterol induced an increase in phosphorylated inhibitory kappaB-alpha, NF-kappaB p65 and NF-kappaB p50 levels, binding of NF-kappaB p65 to DNA, and activation of Akt.	7-ketocholesterol	0-17	synaptotagmin 1	Rattus norvegicus	91-94
21035514-5	2011	7-Ketocholesterol induced an increase in phosphorylated inhibitory kappaB-alpha, NF-kappaB p65 and NF-kappaB p50 levels, binding of NF-kappaB p65 to DNA, and activation of Akt.	7-ketocholesterol	0-17	synaptotagmin 1	Rattus norvegicus	142-145
21035514-5	2011	7-Ketocholesterol induced an increase in phosphorylated inhibitory kappaB-alpha, NF-kappaB p65 and NF-kappaB p50 levels, binding of NF-kappaB p65 to DNA, and activation of Akt.	7-ketocholesterol	0-17	AKT serine/threonine kinase 1	Rattus norvegicus	172-175
21035514-6	2011	Treatment with Bay 11-7085 (an inhibitor of NF-kappaB activation) and oxidant scavengers, including N-acetylcysteine, prevented the 7-ketocholesterol-induced formation of reactive oxygen species, activation of NF-kappaB, Akt and apoptosis-related proteins, and cell death.	7-ketocholesterol	132-149	AKT serine/threonine kinase 1	Rattus norvegicus	221-224
21035514-7	2011	Results from this study suggest that 7-ketocholesterol may exert an apoptotic effect against PC12 cells by inducing activation of the caspase-8-dependent pathway as well as activation of the mitochondria-mediated cell death pathway, leading to activation of caspases, via the reactive oxygen species-dependent activation of NF-kappaB, which is mediated by the Akt pathway.	7-ketocholesterol	37-54	caspase 8	Rattus norvegicus	134-143
21035514-7	2011	Results from this study suggest that 7-ketocholesterol may exert an apoptotic effect against PC12 cells by inducing activation of the caspase-8-dependent pathway as well as activation of the mitochondria-mediated cell death pathway, leading to activation of caspases, via the reactive oxygen species-dependent activation of NF-kappaB, which is mediated by the Akt pathway.	7-ketocholesterol	37-54	caspase 8	Rattus norvegicus	258-266
21035514-7	2011	Results from this study suggest that 7-ketocholesterol may exert an apoptotic effect against PC12 cells by inducing activation of the caspase-8-dependent pathway as well as activation of the mitochondria-mediated cell death pathway, leading to activation of caspases, via the reactive oxygen species-dependent activation of NF-kappaB, which is mediated by the Akt pathway.	7-ketocholesterol	37-54	AKT serine/threonine kinase 1	Rattus norvegicus	360-363
20466046-0	2010	7-Ketocholesterol and cholesterol-5alpha,6alpha-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathways.	7-ketocholesterol	0-17	epidermal growth factor receptor	Homo sapiens	122-154
20570635-7	2010	Trophoblasts transfected with ABCA1 or ABCG1 siRNA were more sensitive to toxic oxysterols substrates (25-hydroxycholesterol and 7-ketocholesterol) compared to mock-transfected cells, while prior treatment with T0901317 reduced oxysterol-mediated toxicity.	7-ketocholesterol	129-146	ATP binding cassette subfamily A member 1	Homo sapiens	30-35
20570635-7	2010	Trophoblasts transfected with ABCA1 or ABCG1 siRNA were more sensitive to toxic oxysterols substrates (25-hydroxycholesterol and 7-ketocholesterol) compared to mock-transfected cells, while prior treatment with T0901317 reduced oxysterol-mediated toxicity.	7-ketocholesterol	129-146	ATP binding cassette subfamily G member 1	Homo sapiens	39-44
20554621-0	2010	7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFkappaB but independently of reactive oxygen species formation.	7-ketocholesterol	0-17	nuclear factor kappa B subunit 1	Homo sapiens	94-102
20466046-0	2010	7-Ketocholesterol and cholesterol-5alpha,6alpha-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathways.	7-ketocholesterol	0-17	AKT serine/threonine kinase 1	Homo sapiens	181-184
20424663-0	2010	7-ketocholesterol induces cell apoptosis by activation of nuclear factor kappa B in mouse macrophages.	7-ketocholesterol	0-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	58-80
20412422-9	2010	Among oxidized lipids and chemically modified LDL, 7-ketocholesterol enhanced IL-8 production.	7-ketocholesterol	51-68	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
20463934-0	2010	Iron nanoparticles increase 7-ketocholesterol-induced cell death, inflammation, and oxidation on murine cardiac HL1-NB cells.	7-ketocholesterol	28-45	asialoglycoprotein receptor 1	Mus musculus	112-115
20424663-4	2010	Results showed that 7-KC-stimulation in J774A.1 cells activated NF-kappaB, which is involved in cell apoptosis, in a time- and dose-dependent manners.	7-ketocholesterol	20-24	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	64-73
20424663-7	2010	Taken together, 7-KC may be an important factor in atherosclerosis due to the ability of 7-KC to induce cell apoptosis, which is at least partially mediated through the activation of NF-kappaB.	7-ketocholesterol	16-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	183-192
20424663-7	2010	Taken together, 7-KC may be an important factor in atherosclerosis due to the ability of 7-KC to induce cell apoptosis, which is at least partially mediated through the activation of NF-kappaB.	7-ketocholesterol	89-93	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	183-192
19224871-2	2009	We show here that ORP2 also binds 22(R)-hydroxycholesterol [22(R)OHC], 7-ketocholesterol, and cholesterol, with 22(R)OHC being the highest affinity ligand of ORP2 (K(d) 1.4 x 10(-8) M).	7-ketocholesterol	71-88	oxysterol binding protein like 2	Homo sapiens	18-22
20423610-2	2010	The goal of in vitro part of work was to observe influence of 7-ketocholesterol on iNOS and MIP1 Beta production in bronchoalveolar lavage fluid (BALF) cells.	7-ketocholesterol	62-79	nitric oxide synthase 2	Sus scrofa	83-87
20423610-2	2010	The goal of in vitro part of work was to observe influence of 7-ketocholesterol on iNOS and MIP1 Beta production in bronchoalveolar lavage fluid (BALF) cells.	7-ketocholesterol	62-79	C-C motif chemokine 4	Sus scrofa	92-101
20423610-6	2010	In the in vitro experiments we show dose-dependent increase of MIP1 Beta and decrease of CYP27A1, iNOS protein production after 7-ketocholesterol treatment.	7-ketocholesterol	128-145	C-C motif chemokine 4	Sus scrofa	63-72
20423610-6	2010	In the in vitro experiments we show dose-dependent increase of MIP1 Beta and decrease of CYP27A1, iNOS protein production after 7-ketocholesterol treatment.	7-ketocholesterol	128-145	cytochrome P450 family 27 subfamily A member 1	Sus scrofa	89-96
20423610-6	2010	In the in vitro experiments we show dose-dependent increase of MIP1 Beta and decrease of CYP27A1, iNOS protein production after 7-ketocholesterol treatment.	7-ketocholesterol	128-145	nitric oxide synthase 2	Sus scrofa	98-102
19957203-3	2010	Tyrphostin AG126 significantly attenuated the 7-ketocholesterol-induced decrease in cytosolic Bid and Bcl-2 levels, increase in cytosolic pro-apoptotic Bax levels, mitochondrial membrane potential loss, cytochrome c release and subsequent caspase-3 activation.	7-ketocholesterol	46-63	BH3 interacting domain death agonist	Rattus norvegicus	94-97
19957203-3	2010	Tyrphostin AG126 significantly attenuated the 7-ketocholesterol-induced decrease in cytosolic Bid and Bcl-2 levels, increase in cytosolic pro-apoptotic Bax levels, mitochondrial membrane potential loss, cytochrome c release and subsequent caspase-3 activation.	7-ketocholesterol	46-63	BCL2, apoptosis regulator	Rattus norvegicus	102-107
19957203-3	2010	Tyrphostin AG126 significantly attenuated the 7-ketocholesterol-induced decrease in cytosolic Bid and Bcl-2 levels, increase in cytosolic pro-apoptotic Bax levels, mitochondrial membrane potential loss, cytochrome c release and subsequent caspase-3 activation.	7-ketocholesterol	46-63	caspase 3	Rattus norvegicus	239-248
19957203-5	2010	The results show that tyrphostin AG126 may prevent the 7-ketocholesterol toxicity by suppressing the mitochondrial membrane permeability change that leads to the cytochrome c release and caspase-3 activation.	7-ketocholesterol	55-72	caspase 3	Rattus norvegicus	187-196
20187291-7	2009	OxLDL-induced TRPC1 translocation was dependent on actin cytoskeleton and associated with a dramatic rise of 7-ketocholesterol (a major oxysterol in oxLDL) into caveolar membranes, whereas the caveolar content of cholesterol was unchanged.	7-ketocholesterol	109-126	transient receptor potential cation channel subfamily C member 1	Homo sapiens	14-19
19464253-0	2009	Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol.	7-ketocholesterol	86-103	thymoma viral proto-oncogene 1	Mus musculus	15-18
19464253-2	2009	Previously we observed enhanced degradation of Akt in P388D1 moncocyte/macrophages following treatment with 25-hydroxycholesterol (25-OH) or 7-ketocholesterol (7-KC).	7-ketocholesterol	141-158	thymoma viral proto-oncogene 1	Mus musculus	47-50
19464253-4	2009	We show that treatment with 25-OH or 7-KC results in the accumulation of poly-ubiquitinated Akt, an effect that is enhanced by co-treatment with the proteasome inhibitor MG-132.	7-ketocholesterol	37-41	thymoma viral proto-oncogene 1	Mus musculus	92-95
19157829-7	2010	Concomitantly, it inhibited 7-KC-induced apoptosis, by limiting caspase-3 activation and the modulatory effects of 7-KC on AKT, Bcl-2, Bcl-xL and Bax.	7-ketocholesterol	28-32	BCL2 apoptosis regulator	Homo sapiens	128-133
19157829-7	2010	Concomitantly, it inhibited 7-KC-induced apoptosis, by limiting caspase-3 activation and the modulatory effects of 7-KC on AKT, Bcl-2, Bcl-xL and Bax.	7-ketocholesterol	28-32	BCL2 like 1	Homo sapiens	135-141
19157829-7	2010	Concomitantly, it inhibited 7-KC-induced apoptosis, by limiting caspase-3 activation and the modulatory effects of 7-KC on AKT, Bcl-2, Bcl-xL and Bax.	7-ketocholesterol	28-32	BCL2 associated X, apoptosis regulator	Homo sapiens	146-149
19157829-7	2010	Concomitantly, it inhibited 7-KC-induced apoptosis, by limiting caspase-3 activation and the modulatory effects of 7-KC on AKT, Bcl-2, Bcl-xL and Bax.	7-ketocholesterol	115-119	AKT serine/threonine kinase 1	Homo sapiens	123-126
19157829-7	2010	Concomitantly, it inhibited 7-KC-induced apoptosis, by limiting caspase-3 activation and the modulatory effects of 7-KC on AKT, Bcl-2, Bcl-xL and Bax.	7-ketocholesterol	115-119	BCL2 like 1	Homo sapiens	135-141
19157829-7	2010	Concomitantly, it inhibited 7-KC-induced apoptosis, by limiting caspase-3 activation and the modulatory effects of 7-KC on AKT, Bcl-2, Bcl-xL and Bax.	7-ketocholesterol	115-119	BCL2 associated X, apoptosis regulator	Homo sapiens	146-149
19224363-4	2009	7-Ketocholesterol induced the nuclear damage, loss of the mitochondrial transmembrane potential, increase in the cytosolic Bax and cytochrome c levels, caspase-3 activation and cell death in differentiated PC12 cells.	7-ketocholesterol	0-17	BCL2 associated X, apoptosis regulator	Rattus norvegicus	123-126
19224363-4	2009	7-Ketocholesterol induced the nuclear damage, loss of the mitochondrial transmembrane potential, increase in the cytosolic Bax and cytochrome c levels, caspase-3 activation and cell death in differentiated PC12 cells.	7-ketocholesterol	0-17	caspase 3	Rattus norvegicus	152-161
19224363-5	2009	Glycyrrhizin and 18beta-glycyrrhetinic acid prevented the 7-ketocholesterol-induced mitochondrial damage, leading to caspase-3 activation and cell death.	7-ketocholesterol	58-75	caspase 3	Rattus norvegicus	117-126
19429117-0	2009	Apolipoprotein D modulates F2-isoprostane and 7-ketocholesterol formation and has a neuroprotective effect on organotypic hippocampal cultures after kainate-induced excitotoxic injury.	7-ketocholesterol	46-63	apolipoprotein D	Homo sapiens	0-16
19429117-5	2009	ApoD also attenuated the increase in oxidative products of arachidonic acid and cholesterol, F(2)-isoprostanes and 7-ketocholesterol, respectively, after kainate treatment.	7-ketocholesterol	115-132	apolipoprotein D	Homo sapiens	0-4
19429117-6	2009	In view of the molecular structure of apoD which consists of an eight stranded beta barrel that forms a binding pocket for a number of small hydrophobic molecules, we propose that apoD promotes its neuroprotective effects by binding to arachidonic acid and cholesterol thus preventing their oxidation to neurotoxic products such as 4-hydroxynonenal (4-HNE) and 7-ketocholesterol.	7-ketocholesterol	361-378	apolipoprotein D	Homo sapiens	38-42
19429117-6	2009	In view of the molecular structure of apoD which consists of an eight stranded beta barrel that forms a binding pocket for a number of small hydrophobic molecules, we propose that apoD promotes its neuroprotective effects by binding to arachidonic acid and cholesterol thus preventing their oxidation to neurotoxic products such as 4-hydroxynonenal (4-HNE) and 7-ketocholesterol.	7-ketocholesterol	361-378	apolipoprotein D	Homo sapiens	180-184
19010388-6	2009	In contrast, 7-ketocholesterol (7-KC) did not inhibit 11beta-HSD1 in HEK-293 cells, even in the presence of H6PDH, but inhibited 11beta-HSD1 reductase activity in differentiated THP-1 macrophages (IC(50) 8.1+/-0.9microM).	7-ketocholesterol	13-30	RNA, U1 small nuclear 1	Homo sapiens	129-140
19338772-2	2009	Macrophages lacking the type 2 cannabinoid receptor (CB2) are partially resistant to apoptosis induced by 7-ketocholesterol (7KC).	7-ketocholesterol	106-123	cannabinoid receptor 2 (macrophage)	Mus musculus	53-56
18515973-0	2009	7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells.	7-ketocholesterol	0-17	interleukin 6	Homo sapiens	30-43
19526729-1	2009	7-Ketocholesterol (7-Kchol, oxidized cholesterol) is an important mediator of cell death in atherosclerosis mediated by up-regulated Nox 4 gene expression.	7-ketocholesterol	0-17	NADPH oxidase 4	Homo sapiens	133-138
19526729-1	2009	7-Ketocholesterol (7-Kchol, oxidized cholesterol) is an important mediator of cell death in atherosclerosis mediated by up-regulated Nox 4 gene expression.	7-ketocholesterol	19-26	NADPH oxidase 4	Homo sapiens	133-138
18936140-0	2009	7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation.	7-ketocholesterol	0-17	vascular endothelial growth factor A	Homo sapiens	112-116
18495460-0	2009	Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis.	7-ketocholesterol	128-145	pyruvate dehydrogenase kinase 1	Homo sapiens	50-55
18495460-0	2009	Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis.	7-ketocholesterol	128-145	AKT serine/threonine kinase 1	Homo sapiens	56-59
18515973-1	2009	This study investigated the effects of 7-ketocholesterol on interleukin (IL)-6 expression in vascular smooth muscle cells (VSMC).	7-ketocholesterol	39-56	interleukin 6	Homo sapiens	60-78
18515973-2	2009	Among the 7 IL examined, only IL-6 transcript was increased by 7-ketocholesterol treatment in human aorta smooth muscle cells.	7-ketocholesterol	63-80	interleukin 6	Homo sapiens	30-34
18515973-3	2009	IL-6 transcripts increased up to 24 h after treatment with 7-ketocholesterol, and this effect was profoundly repressed by treatment with p38 MAPK inhibitors and to a lesser extent JNK inhibitors.	7-ketocholesterol	59-76	interleukin 6	Homo sapiens	0-4
18515973-3	2009	IL-6 transcripts increased up to 24 h after treatment with 7-ketocholesterol, and this effect was profoundly repressed by treatment with p38 MAPK inhibitors and to a lesser extent JNK inhibitors.	7-ketocholesterol	59-76	mitogen-activated protein kinase 14	Homo sapiens	137-140
18515973-5	2009	Mechanisms of IL-6 induction by 7-ketocholesterol were investigated in comparison with tumor necrosis factor (TNF)-alpha.	7-ketocholesterol	32-49	interleukin 6	Homo sapiens	14-18
18515973-8	2009	7-ketocholesterol significantly increased the amount of intracellular IL-6 protein in the presence of brefeldin A.	7-ketocholesterol	0-17	interleukin 6	Homo sapiens	70-74
18515973-9	2009	7-Ketocholesterol also enhanced IL-6 release from VSMC.	7-ketocholesterol	0-17	interleukin 6	Homo sapiens	32-36
18515973-10	2009	IL-6 release by 7-ketocholesterol, although significant, was not as remarkable as that induced by TNF-alpha.	7-ketocholesterol	16-33	interleukin 6	Homo sapiens	0-4
18515973-11	2009	These data suggest that 7-ketocholesterol upregulates IL-6 via mechanisms distinct from TNF-alpha and contributes to the intra- and extracellular IL-6 deposits within the vasculature.	7-ketocholesterol	24-41	interleukin 6	Homo sapiens	54-58
18515973-11	2009	These data suggest that 7-ketocholesterol upregulates IL-6 via mechanisms distinct from TNF-alpha and contributes to the intra- and extracellular IL-6 deposits within the vasculature.	7-ketocholesterol	24-41	interleukin 6	Homo sapiens	146-150
18924609-7	2008	More detailed analysis indicated that ABCG1 was expressed primarily in ECs, and that these cells accumulated the oxysterol 7-ketocholesterol (7-KC) when Abcg1(-/-) mice were fed a WTD.	7-ketocholesterol	123-140	uncharacterized protein	Drosophila melanogaster	153-158
18245064-6	2008	Remarkably, PARP inhibition in FCs resulted in significant sensitization to 7-ketocholesterol (7-KC) by increasing cellular-toxic-free cholesterol, potentially through a down-regulation of acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) expression.	7-ketocholesterol	76-93	poly (ADP-ribose) polymerase family, member 1	Mus musculus	12-16
17846428-0	2007	High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1.	7-ketocholesterol	125-142	ATP binding cassette subfamily G member 1	Homo sapiens	147-152
18215741-7	2008	In addition, overexpression of GPx4 lessened atherogenic events induced by the oxidized lipids lysophosphatidylcholine and 7-ketocholesterol, including upregulated expression of adhesion molecules in endothelial cells and adhesion of monocytes to endothelial cells, as well as endothelial necrosis and apoptosis.	7-ketocholesterol	123-140	glutathione peroxidase 4	Mus musculus	31-35
17846428-8	2007	HDL stimulated the efflux of 7-ketocholesterol from Abcg1(+/+), but not from Abcg1(-/-) macrophages.	7-ketocholesterol	29-46	ATP binding cassette subfamily G member 1	Homo sapiens	52-57
17846428-6	2007	In transfected 293 cells, efflux of 7-ketocholesterol and related oxysterols was completely dependent on expression of ABCG1 and the presence of HDL in media.	7-ketocholesterol	36-53	ATP binding cassette subfamily G member 1	Homo sapiens	119-124
17846428-9	2007	In Abcg1(-/-) mice fed a high-cholesterol diet, plasma levels of 7-ketocholesterol were reduced, whereas their macrophages accumulated 7-ketocholesterol.	7-ketocholesterol	65-82	ATP binding cassette subfamily G member 1	Mus musculus	3-8
17325185-0	2007	Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells.	7-ketocholesterol	37-54	caspase 8	Rattus norvegicus	0-9
17846428-9	2007	In Abcg1(-/-) mice fed a high-cholesterol diet, plasma levels of 7-ketocholesterol were reduced, whereas their macrophages accumulated 7-ketocholesterol.	7-ketocholesterol	135-152	ATP binding cassette subfamily G member 1	Mus musculus	3-8
17846428-10	2007	These findings indicate a specific role for ABCG1 in promoting efflux of 7-ketocholesterol and related oxysterols from macrophages onto HDL and in protecting these cells from oxysterol-induced cytotoxicity.	7-ketocholesterol	73-90	ATP binding cassette subfamily G member 1	Homo sapiens	44-49
17453947-11	2007	They also enhanced IL-8 gene expression and IL-8 protein secretion in the following decreasing order: 25-hydroxycholesterol > 24-hydroxycholesterol > 7-ketocholesterol.	7-ketocholesterol	156-173	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
17364953-0	2007	25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages.	7-ketocholesterol	52-69	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
17495602-5	2007	Both CYP27A1 and CYP46A1 are expressed in primate retina indicating that local metabolism of 7-ketocholesterol to nontoxic derivatives is important for preventing retinal degeneration.	7-ketocholesterol	93-110	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	5-12
17495602-5	2007	Both CYP27A1 and CYP46A1 are expressed in primate retina indicating that local metabolism of 7-ketocholesterol to nontoxic derivatives is important for preventing retinal degeneration.	7-ketocholesterol	93-110	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	17-24
17224136-0	2007	Prevention of 7-ketocholesterol-induced mitochondrial damage and cell death by calmodulin inhibition.	7-ketocholesterol	14-31	calmodulin 1	Rattus norvegicus	79-89
17224136-2	2007	The present study investigated the effect of calmodulin antagonists (trifluoperazine, W-7 and calmidazolium) against the cytotoxicity of 7-ketocholesterol in relation to the mitochondria-mediated cell death process and oxidative stress.	7-ketocholesterol	137-154	calmodulin 1	Rattus norvegicus	45-55
17224136-3	2007	PC12 cells exposed to 7-ketocholesterol revealed nuclear damage, decrease in the mitochondrial transmembrane potential, cytosolic accumulation of cytochrome c, activation of caspase-3, increase in the formation of reactive oxygen species and depletion of GSH.	7-ketocholesterol	22-39	caspase 3	Rattus norvegicus	174-183
17224136-5	2007	Calmodulin antagonists attenuated the 7-ketocholesterol-induced nuclear damage, formation of the mitochondrial permeability transition and cell viability loss in PC12 cells.	7-ketocholesterol	38-55	calmodulin 1	Rattus norvegicus	0-10
17224136-6	2007	The results suggest that calmodulin antagonists may prevent the 7-ketocholesterol-induced viability loss in PC12 cells by suppressing formation of the mitochondrial permeability transition, leading to the release of cytochrome c and subsequent activation of caspase-3.	7-ketocholesterol	64-81	calmodulin 1	Rattus norvegicus	25-35
17224136-6	2007	The results suggest that calmodulin antagonists may prevent the 7-ketocholesterol-induced viability loss in PC12 cells by suppressing formation of the mitochondrial permeability transition, leading to the release of cytochrome c and subsequent activation of caspase-3.	7-ketocholesterol	64-81	caspase 3	Rattus norvegicus	258-267
17224136-8	2007	The findings suggest that calmodulin inhibition may exhibit a protective effect against the neurotoxicity of 7-ketocholesterol.	7-ketocholesterol	109-126	calmodulin 1	Rattus norvegicus	26-36
17089016-0	2006	Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function.	7-ketocholesterol	11-28	poly(ADP-ribose) polymerase 1	Homo sapiens	60-87
17172800-4	2007	Tumor necrosis factor-alpha (TNF-alpha), insulin-like growth factor-1 (IGF-1), and 7-ketocholesterol can regulate the expression of autophagic genes, including microtubule-associated protein 1 light chain-3 (MAP1LC3) and Beclin 1, through Akt/PKB and c-jun N-terminal signal pathways in VSMCs.	7-ketocholesterol	83-100	beclin 1	Homo sapiens	221-229
17172800-4	2007	Tumor necrosis factor-alpha (TNF-alpha), insulin-like growth factor-1 (IGF-1), and 7-ketocholesterol can regulate the expression of autophagic genes, including microtubule-associated protein 1 light chain-3 (MAP1LC3) and Beclin 1, through Akt/PKB and c-jun N-terminal signal pathways in VSMCs.	7-ketocholesterol	83-100	AKT serine/threonine kinase 1	Homo sapiens	239-246
17172800-4	2007	Tumor necrosis factor-alpha (TNF-alpha), insulin-like growth factor-1 (IGF-1), and 7-ketocholesterol can regulate the expression of autophagic genes, including microtubule-associated protein 1 light chain-3 (MAP1LC3) and Beclin 1, through Akt/PKB and c-jun N-terminal signal pathways in VSMCs.	7-ketocholesterol	83-100	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	251-256
17151911-0	2007	Differential modulation of 7-ketocholesterol toxicity against PC12 cells by calmodulin antagonists and Ca2+ channel blockers.	7-ketocholesterol	27-44	calmodulin 1	Rattus norvegicus	76-86
17151911-2	2007	Calmodulin antagonists calmidazolium and W-7 prevented the 7-ketocholesterol-induced mitochondrial damage, leading to caspase-3 activation and cell death, whereas Ca2+ channel blocker nicardipine, mitochondrial Ca2+ uptake inhibitor ruthenium red, and cell permeable Ca2+ chelator BAPTA-AM did not reduce it.	7-ketocholesterol	59-76	calmodulin 1	Rattus norvegicus	0-10
17151911-2	2007	Calmodulin antagonists calmidazolium and W-7 prevented the 7-ketocholesterol-induced mitochondrial damage, leading to caspase-3 activation and cell death, whereas Ca2+ channel blocker nicardipine, mitochondrial Ca2+ uptake inhibitor ruthenium red, and cell permeable Ca2+ chelator BAPTA-AM did not reduce it.	7-ketocholesterol	59-76	caspase 3	Rattus norvegicus	118-127
17151911-4	2007	Unlike cell injury, calmodulin antagonists, nicardipine, and BAPTA-AM prevented the 7-ketocholesterol-induced elevations of intracellular Ca2+ levels.	7-ketocholesterol	84-101	calmodulin 1	Rattus norvegicus	20-30
17151911-5	2007	The results show that the cytotoxicity of 7-ketocholesterol seems to be modulated by calmodulin rather than changes in intracellular Ca2+ levels.	7-ketocholesterol	42-59	calmodulin 1	Rattus norvegicus	85-95
17151911-6	2007	Calmodulin antagonists may prevent the cytotoxicity of 7-ketocholesterol by suppressing the mitochondrial permeability transition formation, which is associated with the increased formation of reactive oxygen species and the depletion of GSH.	7-ketocholesterol	55-72	calmodulin 1	Rattus norvegicus	0-10
17089016-14	2006	Our experimental results suggest that although 7-ketocholesterol can activate PARP enzyme in endothelial cells, it is not sufficient on its own to cause impairment in the endothelium-dependent vascular reactivity.	7-ketocholesterol	47-64	poly(ADP-ribose) polymerase 1	Homo sapiens	78-82
16715209-2	2006	7-Ketocholesterol significantly enhanced the MPP(+)-induced nuclear damage, decrease in the mitochondrial transmembrane potential, cytosolic accumulation of cytochrome c, activation of caspase-3, increase in the formation of reactive oxygen species and depletion of GSH.	7-ketocholesterol	0-17	caspase 3	Rattus norvegicus	185-194
16962939-0	2006	Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio.	7-ketocholesterol	143-160	myeloperoxidase	Homo sapiens	16-31
16715209-5	2006	7-Ketocholesterol may enhance the MPP(+)-induced viability loss in PC12 cells by promoting the mitochondrial membrane permeability change, release of cytochrome c and subsequent activation of caspase-3, which is associated with the increased formation of reactive oxygen species and depletion of GSH.	7-ketocholesterol	0-17	caspase 3	Rattus norvegicus	192-201
17122150-0	2006	Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.	7-ketocholesterol	51-68	caspase 8	Homo sapiens	14-23
16549062-1	2006	Sterol 27-hydroxylase (CYP27A1) is a mitochondrial P-450 enzyme with broad substrate specificity for C27 sterols including 7-ketocholesterol (7kCh).	7-ketocholesterol	123-140	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	0-21
16919261-2	2006	The objectives of the present study were to determine the effects of azelnidipine, a new calcium channel blocker, on the expression of VCAM-1 induced by 7-ketocholesterol, components of ox-LDL, and tumor necrosis factor-alpha (TNF-alpha).	7-ketocholesterol	153-170	vascular cell adhesion molecule 1	Homo sapiens	135-141
16919261-6	2006	The surface expression and mRNA levels of VCAM-1 were determined by enzyme immunoassay and RT-PCR performed on endothelial cell monolayers stimulated with 7-ketocholesterol or TNF-alpha.	7-ketocholesterol	155-172	vascular cell adhesion molecule 1	Homo sapiens	42-48
16919261-13	2006	These results suggest that azelnidipine works as an anti-atherogenic agent by inhibiting the reactive oxygen species-dependent expression of VCAM-1 induced by 7-ketocholesterol and TNF-alpha.	7-ketocholesterol	159-176	vascular cell adhesion molecule 1	Homo sapiens	141-147
16549062-1	2006	Sterol 27-hydroxylase (CYP27A1) is a mitochondrial P-450 enzyme with broad substrate specificity for C27 sterols including 7-ketocholesterol (7kCh).	7-ketocholesterol	123-140	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	23-30
15993097-0	2005	TNF-alpha activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterol.	7-ketocholesterol	87-104	tumor necrosis factor	Homo sapiens	0-9
16984105-1	2006	Preincubation of macrophages with atorvastatin, cholesterol, 25-, 27-hydroxycholesterol, and 7-ketocholesterol reduced the level of TNF-alpha to 10, 61, 13, 64.5, and 82%, respectively.	7-ketocholesterol	93-110	tumor necrosis factor	Mus musculus	132-141
15995174-1	2005	7-Ketocholesterol (7KC) is a cytotoxic component of oxidized low density lipoproteins (OxLDLs) and induces apoptosis in macrophages by a mechanism involving the activation of cytosolic phospholipase A2 (cPLA2).	7-ketocholesterol	0-17	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	175-201
15995174-1	2005	7-Ketocholesterol (7KC) is a cytotoxic component of oxidized low density lipoproteins (OxLDLs) and induces apoptosis in macrophages by a mechanism involving the activation of cytosolic phospholipase A2 (cPLA2).	7-ketocholesterol	0-17	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	203-208
16962939-3	2006	The 7beta-hydroxycholesterol/7-ketocholesterol ratio was markedly higher in MPO/H2O2/nitrite-oxLDL than in Cu2+ -oxidized LDL (7.9 +/- 3.0 versus 0.94 +/- 0.10).	7-ketocholesterol	29-46	myeloperoxidase	Homo sapiens	76-79
15993097-2	2005	We found that 7-ketocholesterol changed the viability of human aorta smooth muscle cells (HAoSMC) not by cytotoxicity but by activation of tumor necrosis factor-alpha receptor (TNFR)-mediated death.	7-ketocholesterol	14-31	TNF receptor superfamily member 1A	Homo sapiens	139-175
15993097-2	2005	We found that 7-ketocholesterol changed the viability of human aorta smooth muscle cells (HAoSMC) not by cytotoxicity but by activation of tumor necrosis factor-alpha receptor (TNFR)-mediated death.	7-ketocholesterol	14-31	TNF receptor superfamily member 1A	Homo sapiens	177-181
15993097-6	2005	7-Ketocholesterol inhibited translocation of the nuclear factor kappaB (NF-kappaB) subunits of p65 and p50 from the cytosol into the nucleus, increase of NF-kappaB activity, and expression of caspase-8 homolog Fas ligand interleukin-1-converting enzyme inhibitory protein by TNF-alpha.	7-ketocholesterol	0-17	nuclear factor kappa B subunit 1	Homo sapiens	72-81
15993097-6	2005	7-Ketocholesterol inhibited translocation of the nuclear factor kappaB (NF-kappaB) subunits of p65 and p50 from the cytosol into the nucleus, increase of NF-kappaB activity, and expression of caspase-8 homolog Fas ligand interleukin-1-converting enzyme inhibitory protein by TNF-alpha.	7-ketocholesterol	0-17	RELA proto-oncogene, NF-kB subunit	Homo sapiens	95-98
16042420-0	2005	The polar nature of 7-ketocholesterol determines its location within membrane domains and the kinetics of membrane microsolubilization by apolipoprotein A-I.	7-ketocholesterol	20-37	apolipoprotein A1	Homo sapiens	138-156
15993097-6	2005	7-Ketocholesterol inhibited translocation of the nuclear factor kappaB (NF-kappaB) subunits of p65 and p50 from the cytosol into the nucleus, increase of NF-kappaB activity, and expression of caspase-8 homolog Fas ligand interleukin-1-converting enzyme inhibitory protein by TNF-alpha.	7-ketocholesterol	0-17	nuclear factor kappa B subunit 1	Homo sapiens	103-106
16042420-8	2005	Compared to cholesterol, 7-ketocholesterol decreased the rate for the microsolubilization of dimyristoyl-PC multilamellar vesicles by apolipoprotein A-I.	7-ketocholesterol	25-42	apolipoprotein A1	Homo sapiens	134-152
15993097-6	2005	7-Ketocholesterol inhibited translocation of the nuclear factor kappaB (NF-kappaB) subunits of p65 and p50 from the cytosol into the nucleus, increase of NF-kappaB activity, and expression of caspase-8 homolog Fas ligand interleukin-1-converting enzyme inhibitory protein by TNF-alpha.	7-ketocholesterol	0-17	nuclear factor kappa B subunit 1	Homo sapiens	154-163
15993097-6	2005	7-Ketocholesterol inhibited translocation of the nuclear factor kappaB (NF-kappaB) subunits of p65 and p50 from the cytosol into the nucleus, increase of NF-kappaB activity, and expression of caspase-8 homolog Fas ligand interleukin-1-converting enzyme inhibitory protein by TNF-alpha.	7-ketocholesterol	0-17	caspase 8	Homo sapiens	192-201
15993097-6	2005	7-Ketocholesterol inhibited translocation of the nuclear factor kappaB (NF-kappaB) subunits of p65 and p50 from the cytosol into the nucleus, increase of NF-kappaB activity, and expression of caspase-8 homolog Fas ligand interleukin-1-converting enzyme inhibitory protein by TNF-alpha.	7-ketocholesterol	0-17	tumor necrosis factor	Homo sapiens	275-284
15955068-8	2005	Indeed, 7-ketocholesterol treatment of human monocytic THP-1 cells induces the release of Bim-LC8 from the microtubule-associated dynein motor complex, and its association with Bcl-2.	7-ketocholesterol	8-25	BCL2 apoptosis regulator	Homo sapiens	177-182
16087724-7	2005	7-ketocholesterol (7KC) was stereospecifically converted to 7beta-hydroxycholesterol by recombinant 11beta-HSD1 from all species analyzed except hamster, which showed a slight preference for the formation of 7alpha-hydroxycholesterol.	7-ketocholesterol	0-17	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	100-111
16292754-0	2005	Activation of caspase-3-dependent and -independent pathways during 7-ketocholesterol- and 7beta-hydroxycholesterol-induced cell death: a morphological and biochemical study.	7-ketocholesterol	67-84	caspase 3	Homo sapiens	14-23
15572675-7	2004	Silencing of IRE-1 and JNK inhibition downregulated Nox-4 expression and subsequently prevented the UPR-dependent cell death induced by 7-Kchol.	7-ketocholesterol	136-143	NADPH oxidase 4	Homo sapiens	52-57
16394614-0	2005	Enhancement of MMP-9 activity in THP-1 cells by 7-ketocholesterol and its suppression by the HMG-CoA reductase inhibitor fluvastatin.	7-ketocholesterol	48-65	matrix metallopeptidase 9	Homo sapiens	15-20
16394614-1	2005	We investigated the effect of 7-ketocholesterol (7-KCHO) on the activity of matrix metalloproteinase (MMP-9) in human monocytic THP-1 cells, and the inhibition of this effect by fluvastatin.	7-ketocholesterol	30-47	matrix metallopeptidase 9	Homo sapiens	102-107
16394614-2	2005	In cells incubated with 7-KCHO or cholesterol, the activity of MMP-9 was enhanced, accompanying an increase in the secretion of MMP-9 proenzyme (pro-MMP-9).	7-ketocholesterol	24-30	matrix metallopeptidase 9	Homo sapiens	63-68
16394614-2	2005	In cells incubated with 7-KCHO or cholesterol, the activity of MMP-9 was enhanced, accompanying an increase in the secretion of MMP-9 proenzyme (pro-MMP-9).	7-ketocholesterol	24-30	matrix metallopeptidase 9	Homo sapiens	128-133
16394614-2	2005	In cells incubated with 7-KCHO or cholesterol, the activity of MMP-9 was enhanced, accompanying an increase in the secretion of MMP-9 proenzyme (pro-MMP-9).	7-ketocholesterol	24-30	matrix metallopeptidase 9	Homo sapiens	128-133
16394614-3	2005	However, the activity of MMP-9 and the amount of pro-MMP-9 were significantly greater following incubation with 7-KCHO than cholesterol.	7-ketocholesterol	112-118	matrix metallopeptidase 9	Homo sapiens	25-30
16394614-3	2005	However, the activity of MMP-9 and the amount of pro-MMP-9 were significantly greater following incubation with 7-KCHO than cholesterol.	7-ketocholesterol	112-118	matrix metallopeptidase 9	Homo sapiens	53-58
16394614-5	2005	When fluvastatin was added to the cells, the MMP-9 activity stimulated by 7-KCHO or cholesterol decreased significantly, accompanying a decrease in the secretion of pro-MMP-9 and TIMP-1.	7-ketocholesterol	74-80	matrix metallopeptidase 9	Homo sapiens	45-50
16394614-6	2005	The inhibition of pro-MMP-9 secretion by fluvastatin was stronger in the cells incubated with 7-KCHO than with cholesterol.	7-ketocholesterol	94-100	matrix metallopeptidase 9	Homo sapiens	22-27
16394614-7	2005	These results suggest that 7-KCHO activates macrophage and enhances MMP-9 activity, and its effects may be inhibited by fluvastatin.	7-ketocholesterol	27-33	matrix metallopeptidase 9	Homo sapiens	68-73
15572675-0	2004	NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells.	7-ketocholesterol	31-48	NADPH oxidase 4	Homo sapiens	16-21
15572675-3	2004	This specific effect of 7-Kchol is mediated by a robust upregulation (threefold from the basal level) of Nox-4, a reactive oxygen species (ROS)-generating NAD(P)H oxidase homologue.	7-ketocholesterol	24-31	NADPH oxidase 4	Homo sapiens	105-110
15572675-4	2004	This effect was highlighted by silencing Nox-4 expression with a specific small interfering RNA, which significantly reduced the 7-Kchol-induced production of ROS and abolished apoptotic events.	7-ketocholesterol	129-136	NADPH oxidase 4	Homo sapiens	41-46
15572675-5	2004	Furthermore, the 7-Kchol activating pathway included an early triggering of endoplasmic reticulum stress, as assessed by transient intracellular Ca(2+) oscillations, and the induction of the expression of the cell death effector CHOP and of GRP78/Bip chaperone via the activation of IRE-1, all hallmarks of the unfolded protein response (UPR).	7-ketocholesterol	17-24	heat shock protein family A (Hsp70) member 5	Homo sapiens	241-246
15572675-5	2004	Furthermore, the 7-Kchol activating pathway included an early triggering of endoplasmic reticulum stress, as assessed by transient intracellular Ca(2+) oscillations, and the induction of the expression of the cell death effector CHOP and of GRP78/Bip chaperone via the activation of IRE-1, all hallmarks of the unfolded protein response (UPR).	7-ketocholesterol	17-24	heat shock protein family A (Hsp70) member 5	Homo sapiens	247-250
15572675-5	2004	Furthermore, the 7-Kchol activating pathway included an early triggering of endoplasmic reticulum stress, as assessed by transient intracellular Ca(2+) oscillations, and the induction of the expression of the cell death effector CHOP and of GRP78/Bip chaperone via the activation of IRE-1, all hallmarks of the unfolded protein response (UPR).	7-ketocholesterol	17-24	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	283-288
15572675-6	2004	We also showed that 7-Kchol activated the IRE-1/Jun-NH(2)-terminal kinase (JNK)/AP-1 signaling pathway to promote Nox-4 expression.	7-ketocholesterol	20-27	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	42-47
15572675-6	2004	We also showed that 7-Kchol activated the IRE-1/Jun-NH(2)-terminal kinase (JNK)/AP-1 signaling pathway to promote Nox-4 expression.	7-ketocholesterol	20-27	mitogen-activated protein kinase 8	Homo sapiens	75-78
15572675-6	2004	We also showed that 7-Kchol activated the IRE-1/Jun-NH(2)-terminal kinase (JNK)/AP-1 signaling pathway to promote Nox-4 expression.	7-ketocholesterol	20-27	NADPH oxidase 4	Homo sapiens	114-119
15572675-7	2004	Silencing of IRE-1 and JNK inhibition downregulated Nox-4 expression and subsequently prevented the UPR-dependent cell death induced by 7-Kchol.	7-ketocholesterol	136-143	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	13-18
15572675-7	2004	Silencing of IRE-1 and JNK inhibition downregulated Nox-4 expression and subsequently prevented the UPR-dependent cell death induced by 7-Kchol.	7-ketocholesterol	136-143	mitogen-activated protein kinase 8	Homo sapiens	23-26
15458974-0	2004	7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells.	7-ketocholesterol	0-17	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	79-92
15572675-8	2004	These findings demonstrate that Nox-4 plays a key role in 7-Kchol-induced SMC death, which is consistent with the hypothesis that Nox-4/oxysterols are involved in the pathogenesis of atherosclerosis.	7-ketocholesterol	58-65	NADPH oxidase 4	Homo sapiens	32-37
15572675-8	2004	These findings demonstrate that Nox-4 plays a key role in 7-Kchol-induced SMC death, which is consistent with the hypothesis that Nox-4/oxysterols are involved in the pathogenesis of atherosclerosis.	7-ketocholesterol	58-65	NADPH oxidase 4	Homo sapiens	130-135
15105836-0	2004	Involvement of a calcium-dependent dephosphorylation of BAD associated with the localization of Trpc-1 within lipid rafts in 7-ketocholesterol-induced THP-1 cell apoptosis.	7-ketocholesterol	125-142	transient receptor potential cation channel subfamily C member 1	Homo sapiens	96-102
15364622-0	2004	7-Ketocholesterol induces reversible cytochrome c release in smooth muscle cells in absence of mitochondrial swelling.	7-ketocholesterol	0-17	cytochrome c	Oryctolagus cuniculus	37-49
15364622-5	2004	RESULTS: 7-Ketocholesterol induced rapid upregulation of the proapoptotic protein Bax and its translocation from cytosol into the mitochondria (4 h).	7-ketocholesterol	9-26	apoptosis regulator BAX	Oryctolagus cuniculus	82-85
15364622-9	2004	Interestingly, upon removal of 7-ketocholesterol after 16 h and re-exposure to serum for 24 h, the mitochondrial cytochrome c content, their transmembrane potential and TUNEL labelling normalised and SMC loss decreased.	7-ketocholesterol	31-48	cytochrome c	Oryctolagus cuniculus	113-125
15105836-5	2004	This 7-ketocholesterol-induced apoptosis appears to be associated with the dephosphorylation of serine 75 and serine 99 of the proapoptotic protein Bcl-2 antagonist of cell death (BAD).	7-ketocholesterol	5-22	BCL2 apoptosis regulator	Homo sapiens	148-153
15148252-7	2004	4 Furthermore, 7-ketocholesterol, an oxidized lipid in oxLDL particles, induced the production of fibronectin and the activation of SP-1, which were also suppressed by Ginkgolon-24.	7-ketocholesterol	15-32	fibronectin 1	Rattus norvegicus	98-109
15152005-2	2004	In addition, 11beta-HSD1 plays a potential role in 7-ketocholesterol metabolism.	7-ketocholesterol	51-68	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	13-24
15152005-10	2004	Furthermore, we demonstrate that 11beta-HSD1, but not mutant K5S/K6S with cytoplasmic orientation, catalyzes the oxoreduction of 7-ketocholesterol.	7-ketocholesterol	129-146	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	33-44
14992685-0	2004	Lysophosphatidylcholine and 7-oxocholesterol modulate Ca2+ signals and inhibit the phosphorylation of endothelial NO synthase and cytosolic phospholipase A2.	7-ketocholesterol	28-44	phospholipase A2 group IVA	Homo sapiens	130-156
14992685-4	2004	In the present study, we investigated the ability of 7-oxocholesterol and LPC to regulate the activation of eNOS (endothelial nitric oxide synthase) and cPLA2 (cytosolic phospholipase A2) that synthesize two essential factors for vascular wall integrity, NO (nitric oxide) and arachidonic acid.	7-ketocholesterol	53-69	nitric oxide synthase 3	Homo sapiens	114-147
14992685-4	2004	In the present study, we investigated the ability of 7-oxocholesterol and LPC to regulate the activation of eNOS (endothelial nitric oxide synthase) and cPLA2 (cytosolic phospholipase A2) that synthesize two essential factors for vascular wall integrity, NO (nitric oxide) and arachidonic acid.	7-ketocholesterol	53-69	phospholipase A2 group IVA	Homo sapiens	153-158
14992685-4	2004	In the present study, we investigated the ability of 7-oxocholesterol and LPC to regulate the activation of eNOS (endothelial nitric oxide synthase) and cPLA2 (cytosolic phospholipase A2) that synthesize two essential factors for vascular wall integrity, NO (nitric oxide) and arachidonic acid.	7-ketocholesterol	53-69	phospholipase A2 group IVA	Homo sapiens	160-186
14992685-11	2004	The results show that 7-oxocholesterol inhibits eNOS and cPLA2 activation by altering a Ca2+-independent upstream step of PI3K and ERK1/2 cascades, whereas LPC desensitizes eNOS by interfering with receptor-activated signalling pathways.	7-ketocholesterol	22-38	phospholipase A2 group IVA	Homo sapiens	57-62
14992685-11	2004	The results show that 7-oxocholesterol inhibits eNOS and cPLA2 activation by altering a Ca2+-independent upstream step of PI3K and ERK1/2 cascades, whereas LPC desensitizes eNOS by interfering with receptor-activated signalling pathways.	7-ketocholesterol	22-38	mitogen-activated protein kinase 3	Homo sapiens	131-137
14644170-4	2003	The 7-ketocholesterol induced cell arborisation, with bundling of vimentin and tubulin in the cell processes and formation of filopodia and stress fibres.	7-ketocholesterol	4-21	vimentin	Homo sapiens	66-74
14973125-0	2004	Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme.	7-ketocholesterol	28-45	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	49-91
14973125-3	2004	Here, we demonstrate a role of 11beta-HSD1 in the metabolism of 7-ketocholesterol (7KC), the major dietary oxysterol.	7-ketocholesterol	64-81	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	31-42
14977888-5	2004	By contrast, when given alone, 7-ketocholesterol strongly stimulated the mitochondrial pathway of apoptosis with cytochrome c release, caspase-9 activation, and eventually caspase-3 activation.	7-ketocholesterol	31-48	cytochrome c, somatic	Homo sapiens	113-125
14977888-5	2004	By contrast, when given alone, 7-ketocholesterol strongly stimulated the mitochondrial pathway of apoptosis with cytochrome c release, caspase-9 activation, and eventually caspase-3 activation.	7-ketocholesterol	31-48	caspase 9	Homo sapiens	135-144
14977888-5	2004	By contrast, when given alone, 7-ketocholesterol strongly stimulated the mitochondrial pathway of apoptosis with cytochrome c release, caspase-9 activation, and eventually caspase-3 activation.	7-ketocholesterol	31-48	caspase 3	Homo sapiens	172-181
14977888-8	2004	Furthermore, this increase in intracellular ROS appeared to be responsible for the up-regulation of proapoptotic factor, p21, after treatment with 7-ketocholesterol but not in cells challenged with the oxysterol mixture.	7-ketocholesterol	147-164	H3 histone pseudogene 16	Homo sapiens	121-124
14734645-7	2004	Conditions that selectively deplete plasma membrane lipid raft cholesterol, such as incorporation of 7-ketocholesterol or rapid exposure to cyclodextrins, block apoA-1 binding to these domains but also inhibit cholesterol efflux from the major, slow pool.	7-ketocholesterol	101-118	apolipoprotein A1	Homo sapiens	161-167
15720835-6	2004	In conclusion, this study suggests that the endothelial adhesiveness to monocytic cells that was increased by 7-ketocholesterol was associated with enhanced expression of ICAM-1 and VCAM-1 mediated by ROS production.	7-ketocholesterol	110-127	intercellular adhesion molecule 1	Homo sapiens	171-177
15720835-6	2004	In conclusion, this study suggests that the endothelial adhesiveness to monocytic cells that was increased by 7-ketocholesterol was associated with enhanced expression of ICAM-1 and VCAM-1 mediated by ROS production.	7-ketocholesterol	110-127	vascular cell adhesion molecule 1	Homo sapiens	182-188
14657223-4	2003	7-ketocholesterol rapidly entered the nucleus and activated poly(ADP-ribose)-polymerase (PARP)-1, followed by the expression of migration-regulating integrins CD11a and intercellular adhesion molecule 1.	7-ketocholesterol	0-17	poly(ADP-ribose) polymerase 1	Homo sapiens	60-96
14657223-4	2003	7-ketocholesterol rapidly entered the nucleus and activated poly(ADP-ribose)-polymerase (PARP)-1, followed by the expression of migration-regulating integrins CD11a and intercellular adhesion molecule 1.	7-ketocholesterol	0-17	integrin subunit alpha L	Homo sapiens	159-164
14657223-4	2003	7-ketocholesterol rapidly entered the nucleus and activated poly(ADP-ribose)-polymerase (PARP)-1, followed by the expression of migration-regulating integrins CD11a and intercellular adhesion molecule 1.	7-ketocholesterol	0-17	intercellular adhesion molecule 1	Homo sapiens	169-202
15169886-5	2004	Transient and stable transfection assays indicated that these compounds increased the PON-1 gene promoter activity in an AhR-dependent manner, since their effect was inhibited by 7-keto-cholesterol and AhR-directed short interfering RNA.	7-ketocholesterol	179-197	paraoxonase 1	Homo sapiens	86-91
15169886-5	2004	Transient and stable transfection assays indicated that these compounds increased the PON-1 gene promoter activity in an AhR-dependent manner, since their effect was inhibited by 7-keto-cholesterol and AhR-directed short interfering RNA.	7-ketocholesterol	179-197	aryl hydrocarbon receptor	Homo sapiens	121-124
14559920-4	2004	In this study, we demonstrate that, in the murine macrophage-like cell line P388D1, oxysterols (25-hydroxycholesterol and 7-ketocholesterol) induced the degradation of the prosurvival protein kinase AKT (protein kinase B).	7-ketocholesterol	122-139	thymoma viral proto-oncogene 1	Mus musculus	199-202
15720835-2	2004	7-ketocholesterol enhances surface expression of ICAM-1 and VCAM-1 as determined by EIA, induces their mRNA expression by RT-PCR, and stimulates adhesiveness of HAECs to U937 monocytic cells.	7-ketocholesterol	0-17	intercellular adhesion molecule 1	Homo sapiens	49-55
15720835-2	2004	7-ketocholesterol enhances surface expression of ICAM-1 and VCAM-1 as determined by EIA, induces their mRNA expression by RT-PCR, and stimulates adhesiveness of HAECs to U937 monocytic cells.	7-ketocholesterol	0-17	vascular cell adhesion molecule 1	Homo sapiens	60-66
15720835-4	2004	Although the surface expression of ICAM-1 and VCAM-1 on HAECs treated with 7-ketocholesterol increased in a time-dependent manner, alpha-tocopherol inhibited this increase of the surface expression of ICAM-1 and VCAM-1.	7-ketocholesterol	75-92	intercellular adhesion molecule 1	Homo sapiens	35-41
15720835-4	2004	Although the surface expression of ICAM-1 and VCAM-1 on HAECs treated with 7-ketocholesterol increased in a time-dependent manner, alpha-tocopherol inhibited this increase of the surface expression of ICAM-1 and VCAM-1.	7-ketocholesterol	75-92	vascular cell adhesion molecule 1	Homo sapiens	46-52
15720835-4	2004	Although the surface expression of ICAM-1 and VCAM-1 on HAECs treated with 7-ketocholesterol increased in a time-dependent manner, alpha-tocopherol inhibited this increase of the surface expression of ICAM-1 and VCAM-1.	7-ketocholesterol	75-92	intercellular adhesion molecule 1	Homo sapiens	201-207
15720835-4	2004	Although the surface expression of ICAM-1 and VCAM-1 on HAECs treated with 7-ketocholesterol increased in a time-dependent manner, alpha-tocopherol inhibited this increase of the surface expression of ICAM-1 and VCAM-1.	7-ketocholesterol	75-92	vascular cell adhesion molecule 1	Homo sapiens	212-218
14644170-8	2003	Indeed, formation of both filopodia and stress fibres induced by 7-ketocholesterol is inhibited by overexpressing dominant negatives forms of Cdc42 and RhoA, respectively.	7-ketocholesterol	65-82	cell division cycle 42	Homo sapiens	142-147
14644170-8	2003	Indeed, formation of both filopodia and stress fibres induced by 7-ketocholesterol is inhibited by overexpressing dominant negatives forms of Cdc42 and RhoA, respectively.	7-ketocholesterol	65-82	ras homolog family member A	Homo sapiens	152-156
14555225-2	2003	Examination of cultured human THP-1 macrophages treated with the cholesterol oxide, 7-ketocholesterol, revealed a concentration- and time-dependent increase in formation of cholesterol crystals in the cells.	7-ketocholesterol	84-101	GLI family zinc finger 2	Homo sapiens	30-35
14521937-7	2003	Furthermore, mithramycin A, an inhibitor of SP-1, also suppressed the oxLDL- and 7-ketocholesterol-stimulated production of fibronectin.	7-ketocholesterol	81-98	fibronectin 1	Rattus norvegicus	124-135
14572579-9	2003	Serum C-reactive protein levels correlated positively with biliary levels of 7-alpha-hydroxycholesterol (R = 0.948), 7-beta-hydroxycholesterol (R = 0.976), cholestan-3-beta,5-alpha,6-beta-triol (R = 0.823), 7-alpha-hydroxy-4-cholesten-3-one (R = 0.846,) and 7-ketocholesterol (R = 0.973).	7-ketocholesterol	258-275	C-reactive protein	Homo sapiens	6-24
14551533-6	2003	RESULTS: LEC incubated with 7-keto presented higher levels of p57KIP2 and showed expression of fiber specific proteins such as MIP26 and CP49, compared to cells incubated with 25-OH or cholesterol.	7-ketocholesterol	28-34	cyclin dependent kinase inhibitor 1C	Homo sapiens	62-69
14551533-6	2003	RESULTS: LEC incubated with 7-keto presented higher levels of p57KIP2 and showed expression of fiber specific proteins such as MIP26 and CP49, compared to cells incubated with 25-OH or cholesterol.	7-ketocholesterol	28-34	major intrinsic protein of lens fiber	Homo sapiens	127-132
14551533-6	2003	RESULTS: LEC incubated with 7-keto presented higher levels of p57KIP2 and showed expression of fiber specific proteins such as MIP26 and CP49, compared to cells incubated with 25-OH or cholesterol.	7-ketocholesterol	28-34	beaded filament structural protein 2	Homo sapiens	137-141
14551533-7	2003	The differentiation marker p57KIP2 increased over time for cells incubated with 7-keto while there was a decline on the amount of the proliferation marker PCNA.	7-ketocholesterol	80-86	cyclin dependent kinase inhibitor 1C	Homo sapiens	27-34
14551533-8	2003	The expression of the fiber specific proteins gamma-crystallin, MIP26 and CP49 was detected after 5 days of incubation with 7-keto.	7-ketocholesterol	124-130	major intrinsic protein of lens fiber	Homo sapiens	64-69
14551533-8	2003	The expression of the fiber specific proteins gamma-crystallin, MIP26 and CP49 was detected after 5 days of incubation with 7-keto.	7-ketocholesterol	124-130	beaded filament structural protein 2	Homo sapiens	74-78
12085989-7	2002	In cultured HepG2 or murine macrophage RAW264.7 cells, 3 days treatment with either 25-hydroxycholesterol or 7-ketocholesterol induced iNOS mRNA expression, as determined by RT-PCR.	7-ketocholesterol	109-126	nitric oxide synthase 2, inducible	Mus musculus	135-139
14521937-6	2003	7-Ketocholesterol, an oxidized lipid in oxLDL particles, induced the production of fibronectin and the activation of SP-1, those which were suppressed by N-acetylcysteine.	7-ketocholesterol	0-17	fibronectin 1	Rattus norvegicus	83-94
12663661-7	2003	The reduction of the core aldehyde levels was accompanied by (i) the formation of free 7-ketocholesterol and 7-ketocholesteryl ester core aldehydes and (ii) an increase in the amounts of apoB-bound cholesterol and 7-ketocholesterol, suggesting that the cholesteryl ester core aldehydes were further converted to their 7-ketocholesterol- and apoB-bound derivatives.	7-ketocholesterol	214-231	apolipoprotein B	Homo sapiens	187-191
12663661-7	2003	The reduction of the core aldehyde levels was accompanied by (i) the formation of free 7-ketocholesterol and 7-ketocholesteryl ester core aldehydes and (ii) an increase in the amounts of apoB-bound cholesterol and 7-ketocholesterol, suggesting that the cholesteryl ester core aldehydes were further converted to their 7-ketocholesterol- and apoB-bound derivatives.	7-ketocholesterol	214-231	apolipoprotein B	Homo sapiens	187-191
12533546-0	2003	Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1.	7-ketocholesterol	27-44	carboxylesterase 1	Homo sapiens	106-149
12020639-0	2002	Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice.	7-ketocholesterol	49-66	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	70-91
11755924-7	2002	Enrichment of MPM from control mice with the major oxysterols found in E(0) MPM (7-ketocholesterol, beta-epoxycholesterol and 7beta-hydroxycholesterol) resulted in a dose-dependent increase (60-80%) in PKC activity, AA release, p47phox translocation, superoxide anion release and cell-mediated oxidation of LDL.	7-ketocholesterol	81-98	neutrophil cytosolic factor 1	Mus musculus	228-235
11884587-2	2002	Using mouse fibroblasts lacking p53, p21(waf1), or Stat1, we found that optimal 7kchol-induced apoptosis requires p21(waf1) and Stat1 but not p53.	7-ketocholesterol	80-86	transformation related protein 53, pseudogene	Mus musculus	32-35
11884587-2	2002	Using mouse fibroblasts lacking p53, p21(waf1), or Stat1, we found that optimal 7kchol-induced apoptosis requires p21(waf1) and Stat1 but not p53.	7-ketocholesterol	80-86	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	37-40
11884587-2	2002	Using mouse fibroblasts lacking p53, p21(waf1), or Stat1, we found that optimal 7kchol-induced apoptosis requires p21(waf1) and Stat1 but not p53.	7-ketocholesterol	80-86	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	41-45
11884587-2	2002	Using mouse fibroblasts lacking p53, p21(waf1), or Stat1, we found that optimal 7kchol-induced apoptosis requires p21(waf1) and Stat1 but not p53.	7-ketocholesterol	80-86	signal transducer and activator of transcription 1	Mus musculus	51-56
11884587-2	2002	Using mouse fibroblasts lacking p53, p21(waf1), or Stat1, we found that optimal 7kchol-induced apoptosis requires p21(waf1) and Stat1 but not p53.	7-ketocholesterol	80-86	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	114-117
11884587-2	2002	Using mouse fibroblasts lacking p53, p21(waf1), or Stat1, we found that optimal 7kchol-induced apoptosis requires p21(waf1) and Stat1 but not p53.	7-ketocholesterol	80-86	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	118-122
11884587-2	2002	Using mouse fibroblasts lacking p53, p21(waf1), or Stat1, we found that optimal 7kchol-induced apoptosis requires p21(waf1) and Stat1 but not p53.	7-ketocholesterol	80-86	signal transducer and activator of transcription 1	Mus musculus	128-133
11884587-2	2002	Using mouse fibroblasts lacking p53, p21(waf1), or Stat1, we found that optimal 7kchol-induced apoptosis requires p21(waf1) and Stat1 but not p53.	7-ketocholesterol	80-86	transformation related protein 53, pseudogene	Mus musculus	142-145
11884587-6	2002	A neutralizing antibody against beta interferon (IFN-beta) blunted Ser(727) phosphorylation and apoptosis after 7kchol treatment; cells deficient in an IFN-beta receptor subunit exhibited blunted apoptosis.	7-ketocholesterol	112-118	interferon beta 1	Homo sapiens	32-57
11884587-6	2002	A neutralizing antibody against beta interferon (IFN-beta) blunted Ser(727) phosphorylation and apoptosis after 7kchol treatment; cells deficient in an IFN-beta receptor subunit exhibited blunted apoptosis.	7-ketocholesterol	112-118	interferon beta 1	Homo sapiens	49-57
11884587-7	2002	IFN-beta alone did not induce apoptosis; thus, 7kchol-induced release of IFN-beta was necessary but not sufficient for optimal apoptosis.	7-ketocholesterol	47-53	interferon beta 1	Homo sapiens	0-8
11884587-7	2002	IFN-beta alone did not induce apoptosis; thus, 7kchol-induced release of IFN-beta was necessary but not sufficient for optimal apoptosis.	7-ketocholesterol	47-53	interferon beta 1	Homo sapiens	73-81
11042205-0	2001	7-ketocholesterol is an endogenous modulator for the arylhydrocarbon receptor.	7-ketocholesterol	0-17	aryl hydrocarbon receptor	Homo sapiens	53-77
11521968-0	2001	Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells.	7-ketocholesterol	28-45	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	50-71
11730812-0	2001	Vascular endothelial growth factor synthesis in vascular smooth muscle cells is enhanced by 7-ketocholesterol and lysophosphatidylcholine independently of their effect on nitric oxide generation.	7-ketocholesterol	92-109	vascular endothelial growth factor A	Rattus norvegicus	0-34
11730812-4	2001	Both LPC and 7-Kchol significantly augmented VEGF production in rat and human VSMC.	7-ketocholesterol	13-20	vascular endothelial growth factor A	Rattus norvegicus	45-49
11730812-5	2001	Increase in VEGF generation was related to the activation of VEGF promoter by both 7-Kchol and LPC and enhancement of VEGF mRNA transcription.	7-ketocholesterol	83-90	vascular endothelial growth factor A	Rattus norvegicus	12-16
11730812-5	2001	Increase in VEGF generation was related to the activation of VEGF promoter by both 7-Kchol and LPC and enhancement of VEGF mRNA transcription.	7-ketocholesterol	83-90	vascular endothelial growth factor A	Rattus norvegicus	61-65
11730812-5	2001	Increase in VEGF generation was related to the activation of VEGF promoter by both 7-Kchol and LPC and enhancement of VEGF mRNA transcription.	7-ketocholesterol	83-90	vascular endothelial growth factor A	Rattus norvegicus	61-65
11730812-7	2001	7-Kchol decreased rat iNOS promoter activity, iNOS expression and NO generation, but it did not impair IL-1beta-induced VEGF synthesis.	7-ketocholesterol	0-7	nitric oxide synthase 2	Rattus norvegicus	22-26
11730812-7	2001	7-Kchol decreased rat iNOS promoter activity, iNOS expression and NO generation, but it did not impair IL-1beta-induced VEGF synthesis.	7-ketocholesterol	0-7	nitric oxide synthase 2	Rattus norvegicus	46-50
11689206-2	2001	We have examined the interaction of recombinant His-tagged caveolin-1 with cholesterol and 7-keto cholesterol, the most abundant non-enzymatically formed oxysterol found in oxidised LDL and atheromatous plaque.	7-ketocholesterol	91-109	caveolin 1	Homo sapiens	59-69
11669638-1	2001	Cholesterol removal from lipid-loaded macrophages is an important, potentially antiatherogenic process, and we have previously shown that an oxysterol, 7-ketocholesterol (7K), can impair efflux to lipid-free apoprotein A-1 (apoA-1).	7-ketocholesterol	152-169	apolipoprotein A1	Homo sapiens	224-230
11278871-11	2001	OSBP2 was found to bind 7-ketocholesterol but to have very little affinity for cholesterol or 25-hydroxycholesterol.	7-ketocholesterol	24-41	oxysterol binding protein 2	Homo sapiens	0-5
11325610-1	2001	Treatment of human umbilical vein endothelial cells (HUVECs) with 7-ketocholesterol resulted in an increased release of soluble vascular cell adhesion molecule-1 (VCAM-1) into culture medium.	7-ketocholesterol	66-83	vascular cell adhesion molecule 1	Homo sapiens	128-161
11325610-1	2001	Treatment of human umbilical vein endothelial cells (HUVECs) with 7-ketocholesterol resulted in an increased release of soluble vascular cell adhesion molecule-1 (VCAM-1) into culture medium.	7-ketocholesterol	66-83	vascular cell adhesion molecule 1	Homo sapiens	163-169
11325610-4	2001	Western blot analysis revealed that soluble VCAM-1, in the conditioned medium of both 7-ketocholesterol-stimulated and control cells, had a molecular size of 100 kDa.	7-ketocholesterol	86-103	vascular cell adhesion molecule 1	Homo sapiens	44-50
11325610-5	2001	Stimulation of the TNF-alpha-treated HUVECs with 7-ketocholesterol further increased the levels of soluble VCAM-1 in the culture medium.	7-ketocholesterol	49-66	tumor necrosis factor	Homo sapiens	19-28
11325610-5	2001	Stimulation of the TNF-alpha-treated HUVECs with 7-ketocholesterol further increased the levels of soluble VCAM-1 in the culture medium.	7-ketocholesterol	49-66	vascular cell adhesion molecule 1	Homo sapiens	107-113
11325610-7	2001	Pretreatment of the cells with tissue inhibitor of membrane metalloproteinase-2 (TIMP-2) completely inhibited the release of VCAM-1 in response to 7-ketocholesterol but TIMP-1 had no effect.	7-ketocholesterol	147-164	vascular cell adhesion molecule 1	Homo sapiens	125-131
11325610-8	2001	Adherence of mononuclear cells to TNF-stimulated HUVEC monolayers was slightly inhibited by 7-ketocholesterol, but this oxysterol did not affect the basal adherence to non-stimulated HUVECs.	7-ketocholesterol	92-109	tumor necrosis factor	Homo sapiens	34-37
11325610-10	2001	We conclude that 7-ketocholesterol releases VCAM-1 from the endothelium probably by a proteolytic process.	7-ketocholesterol	17-34	vascular cell adhesion molecule 1	Homo sapiens	44-50
11042205-1	2001	We have identified 7-ketocholesterol (7-KC) as an endogenous modulator that inhibits transactivation by the arylhydrocarbon receptor (AhR) through competitive binding against xenobiotic ligands.	7-ketocholesterol	19-36	aryl hydrocarbon receptor	Homo sapiens	108-132
11042205-1	2001	We have identified 7-ketocholesterol (7-KC) as an endogenous modulator that inhibits transactivation by the arylhydrocarbon receptor (AhR) through competitive binding against xenobiotic ligands.	7-ketocholesterol	19-36	aryl hydrocarbon receptor	Homo sapiens	134-137
11042205-1	2001	We have identified 7-ketocholesterol (7-KC) as an endogenous modulator that inhibits transactivation by the arylhydrocarbon receptor (AhR) through competitive binding against xenobiotic ligands.	7-ketocholesterol	38-42	aryl hydrocarbon receptor	Homo sapiens	108-132
11042205-1	2001	We have identified 7-ketocholesterol (7-KC) as an endogenous modulator that inhibits transactivation by the arylhydrocarbon receptor (AhR) through competitive binding against xenobiotic ligands.	7-ketocholesterol	38-42	aryl hydrocarbon receptor	Homo sapiens	134-137
11042205-2	2001	7-KC binds AhR and displaces labeled dioxin (2,3,7,8-tetrachlorodibenzo(p)dioxin (TCDD)).	7-ketocholesterol	0-4	aryl hydrocarbon receptor	Homo sapiens	11-14
11042205-7	2001	Injection of 7-KC to rats blocks the induction of CYP 1A1 messenger RNA and protein in endothelial cells from myocardial blood vessels.	7-ketocholesterol	13-17	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	50-57
10938019-6	2000	Moreover, treatment with oxLDL and 7-KC induced much greater death and DNA fragmentation in MSR-A-deficient peritoneal macrophages compared with wild-type macrophages.	7-ketocholesterol	35-39	methionine sulfoxide reductase A	Homo sapiens	92-97
11686311-6	2001	The level of soluble VCAM-1 showed significant correlation between the values of 7-ketocholesterol (r=0.42, p=0.024), TC (r=0.42, p=0.014) and LDL-C (r=0.38, p=0.044).	7-ketocholesterol	81-98	vascular cell adhesion molecule 1	Homo sapiens	21-27
10933125-6	2000	Importantly, the effects of oxysterols, such as 7-ketocholesterol (7KC), on cholesterol and other lipid efflux by apoA-I needs to be investigated in any attempt to utilise apoA-I as an agent to stimulate efflux of lipids.	7-ketocholesterol	48-65	apolipoprotein A1	Homo sapiens	114-120
10869358-0	2000	Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture.	7-ketocholesterol	30-47	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	0-21
10869358-3	2000	We hypothesized and here show that 27-hydroxylated 7-ketocholesterol (270H-7K) is present in human lesions, probably generated by the action of sterol 27-hydroxylase on 7K.	7-ketocholesterol	51-68	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	144-165
10224662-2	1999	7-Ketocholesterol can inhibit cholesterol 7 alpha-hydroxylase, the rate-limiting step in bile acid biosynthesis, as well as strongly inhibiting HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis.	7-ketocholesterol	0-17	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	30-61
10751394-10	2000	Finally, we showed that the lysosomal cholesterol pool in NP-C cells was substantially and preferentially reduced by incubating cells with the oxysterols, 25-hydroxycholesterol and 7-ketocholesterol; these findings suggest a new pharmacological approach to the treatment of NP-C disease.	7-ketocholesterol	181-198	NPC intracellular cholesterol transporter 1	Homo sapiens	58-62
10754270-0	2000	Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis.	7-ketocholesterol	151-168	cytochrome c, somatic	Homo sapiens	122-134
10754270-1	2000	Previous investigations of our laboratory have shown that 7-ketocholesterol was a potent inducer of apoptosis involving a release of cytochrome c into the cytosol, and a lipid peroxidation process that could be the consequence of a production of radical oxygen species.	7-ketocholesterol	58-75	cytochrome c, somatic	Homo sapiens	133-145
10484610-2	1999	For example, 7-ketocholesterol (7KC) inhibits cholesterol efflux from macrophage foam cells induced by apolipoprotein A-I (apoA-I).	7-ketocholesterol	13-30	apolipoprotein A1	Homo sapiens	103-121
10484610-2	1999	For example, 7-ketocholesterol (7KC) inhibits cholesterol efflux from macrophage foam cells induced by apolipoprotein A-I (apoA-I).	7-ketocholesterol	13-30	apolipoprotein A1	Homo sapiens	123-129
10224662-2	1999	7-Ketocholesterol can inhibit cholesterol 7 alpha-hydroxylase, the rate-limiting step in bile acid biosynthesis, as well as strongly inhibiting HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis.	7-ketocholesterol	0-17	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	144-161
10224662-4	1999	However, when tested as a pharmacological cholesterol-lowering agent, inhibition of HMG-CoA reductase was rapidly overcome and the 7-ketocholesterol metabolised.	7-ketocholesterol	131-148	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	84-101
9880570-3	1999	Oxysterols (25-hydroxycholesterol and 7-ketocholesterol) reversed the inhibition of apoB degradation caused by 7alpha-hydroxylase.	7-ketocholesterol	38-55	apolipoprotein B	Homo sapiens	84-88
9644113-6	1998	25-OHCh and 7-KCh inhibited both FcR-dependent binding and phagocytosis of sheep red blood cells (SRBC).	7-ketocholesterol	12-17	Fc receptor	Mus musculus	33-36
9872417-0	1998	Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterol.	7-ketocholesterol	173-190	interleukin 1 beta	Homo sapiens	22-30
9872417-3	1998	Only 7beta-hydroxycholesterol and 7-ketocholesterol were potent inducers of apoptosis and of IL-1beta secretion.	7-ketocholesterol	34-51	interleukin 1 beta	Homo sapiens	93-101
9632680-11	1998	Since 7-oxocholesterol is a potent inhibitor of cholesterol 7alpha-hydroxylase, alternative mechanisms for regulation of bile acid synthesis may exist in human and hamster liver due to production of this metabolite and its potential as an oxysterol.	7-ketocholesterol	6-22	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	48-78
9644113-8	1998	25-OHCh dose-dependently and more efficiently than 7-KCh inhibited murine splenocyte secretion of MAF, which activity was determined by the ability of splenocyte-conditioned medium to stimulate ROI generation in PM.	7-ketocholesterol	51-56	avian musculoaponeurotic fibrosarcoma oncogene homolog	Mus musculus	98-101
9428650-0	1997	Induction of apoptosis and of interleukin-1beta secretion by 7beta-hydroxycholesterol and 7-ketocholesterol: partial inhibition by Bcl-2 overexpression.	7-ketocholesterol	90-107	interleukin 1 beta	Homo sapiens	30-47
9428650-4	1997	7Beta-hydroxycholesterol and 7-ketocholesterol induced nuclear condensation and/or fragmentation, internucleosomal DNA fragmentation, and IL-1beta secretion, which were partially inhibited by Bcl-2 overexpression.	7-ketocholesterol	29-46	interleukin 1 beta	Homo sapiens	138-146
9428650-4	1997	7Beta-hydroxycholesterol and 7-ketocholesterol induced nuclear condensation and/or fragmentation, internucleosomal DNA fragmentation, and IL-1beta secretion, which were partially inhibited by Bcl-2 overexpression.	7-ketocholesterol	29-46	BCL2 apoptosis regulator	Homo sapiens	192-197
9247143-3	1997	Oxysterols (7-ketocholesterol, 25-hydroxycholesterol) induced nuclear condensation and oligonucleosomal DNA fragmentation, which were partially inhibited by Bcl-2 over-expression.	7-ketocholesterol	12-29	B cell leukemia/lymphoma 2	Mus musculus	157-162
9186915-9	1997	Northern blot analysis indicated an increase in apoE mRNA in response to increasing concentrations of 7-ketocholesterol.	7-ketocholesterol	102-119	apolipoprotein E	Homo sapiens	48-52
9186915-10	1997	These results elucidate a potential role of oxidized LDL, and specifically 7-ketocholesterol, in the stimulation of macrophage apoE secretion in atherosclerotic lesions.	7-ketocholesterol	75-92	apolipoprotein E	Homo sapiens	127-131
8354276-0	1993	Cholesterol 7 alpha-hydroxylase is up-regulated by the competitive inhibitor 7-oxocholesterol in rat liver.	7-ketocholesterol	77-93	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	0-31
8910326-11	1996	Efflux of 7-ketocholesterol was time and concentration dependent, and the rate of its removal was 50-fold greater for hydroxypropyl-beta-cyclodextrin than for apolipoprotein A-I.	7-ketocholesterol	10-27	apolipoprotein A1	Homo sapiens	159-177
8885139-3	1996	Cholesterol 5 beta-epoxide and 7-ketocholesterol increased the mobilization of 3H-arachidonic acid from prelabelled platelet phospholipids in response to thrombin and collagen.	7-ketocholesterol	31-48	coagulation factor II, thrombin	Homo sapiens	154-162
7583578-7	1995	7-Ketocholesterol, one of the amphiphilic lipids in OX-LDL that is transferable from OX-LDL to defatted albumin, suppressed CNP secretion by ECs, thus mimicking the effect of OX-LDL.	7-ketocholesterol	0-17	natriuretic peptide C	Bos taurus	124-127
7583578-10	1995	These results indicate that OX-LDL suppresses CNP secretion from ECs by 7-ketocholesterol or other transferable hydrophilic lipids in OX-LDL, and the suppressive effect of OX-LDL is reversed by HDL.	7-ketocholesterol	72-89	natriuretic peptide C	Bos taurus	46-49
8068724-0	1994	The effect of dietary 7-ketocholesterol, inhibitor of sterol synthesis, on hepatic microsomal cholesterol 7 alpha-hydroxylase activity in rat.	7-ketocholesterol	22-39	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	94-125
8831713-3	1996	We show that both 7-ketocholesterol and 25-hydroxycholesterol induced apoptosis, followed by a rapid decrease in bcl-2 protein in the cells.	7-ketocholesterol	18-35	BCL2 apoptosis regulator	Homo sapiens	113-118
8831713-4	1996	CPP32/Yamma inhibitor prevented apoptosis induced by 7-ketocholesterol and 25-hydroxycholesterol in VSMCs, whereas the exogenous cholesterol, which itself did not have any apoptotic activity, inhibited 25-hydroxycholesterol induced apoptosis but the 7-ketocholesterol-induced apoptosis was not affected.	7-ketocholesterol	53-70	caspase 3	Homo sapiens	0-5
8831713-4	1996	CPP32/Yamma inhibitor prevented apoptosis induced by 7-ketocholesterol and 25-hydroxycholesterol in VSMCs, whereas the exogenous cholesterol, which itself did not have any apoptotic activity, inhibited 25-hydroxycholesterol induced apoptosis but the 7-ketocholesterol-induced apoptosis was not affected.	7-ketocholesterol	250-267	caspase 3	Homo sapiens	0-5
8864249-5	1996	The results showed mRNA expressions of LDLR gene were inhibited to 16.1 +/- 4.4%, 33.8 +/- 0.6%, 42.8 +/- 1.8% and 46.9 +/- 3.9% of control by 25-OH, 7-keto, epoxide and triol respectively.	7-ketocholesterol	150-156	low-density lipoprotein receptor	Oryctolagus cuniculus	39-43
8770318-4	1995	Because of recent evidence that 7-ketocholesterol and 7-hydroxycholesterol are toxic species in copper-oxidized LDL, inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase was hypothesized as a mechanism of toxicity.	7-ketocholesterol	32-49	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	131-181
8354276-5	1993	Addition of 7-oxocholesterol to liver microsomes from normal rats in amounts corresponding to those present in microsomes from 7-oxocholesterol-treated rats inhibited the cholesterol 7 alpha-hydroxylase activity by about 75%.	7-ketocholesterol	12-28	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	171-202
8354276-5	1993	Addition of 7-oxocholesterol to liver microsomes from normal rats in amounts corresponding to those present in microsomes from 7-oxocholesterol-treated rats inhibited the cholesterol 7 alpha-hydroxylase activity by about 75%.	7-ketocholesterol	127-143	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	171-202
8354276-8	1993	It is concluded that treatment with the competitive inhibitor 7-oxocholesterol leads to a reduced bile acid biosynthesis and, as a consequence of reduced bile acid inhibition, a compensatory increase in cholesterol 7 alpha-hydroxylase synthesis.	7-ketocholesterol	62-78	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	203-234
4055743-9	1985	By contrast, 7-ketocholesterol and 20 alpha-hydroxycholesterol strongly inhibited cholesterol 7 alpha-hydroxylase activity at low concentrations (10 microM).	7-ketocholesterol	13-30	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	82-113
34936813-10	2022	Conclusions: Inhibition of mTOR signaling pathway suppressed the elevation of inflammatory cytokines IL-6, IL-8, and the angiogenic agent VEGF induced by 7-KC.	7-ketocholesterol	154-158	mechanistic target of rapamycin kinase	Homo sapiens	27-31
34936813-0	2022	Mammalian Target of Rapamycin Inhibitor Rapamycin Alleviates 7-Ketocholesterol Induced Inflammatory Responses and Vascular Endothelial Growth Factor Elevation by Regulating MAPK Pathway in Human Retinal Pigment Epithelium Cells.	7-ketocholesterol	61-78	mechanistic target of rapamycin kinase	Homo sapiens	0-29
34936813-1	2022	Purpose: To validate the protective effect of a mammalian target of rapamycin (mTOR) inhibitor on human retinal pigment epithelium (RPE) cells challenged with 7-ketocholesterol (7-KC) and explored the underlying mechanisms.	7-ketocholesterol	159-176	mechanistic target of rapamycin kinase	Homo sapiens	48-77
34936813-1	2022	Purpose: To validate the protective effect of a mammalian target of rapamycin (mTOR) inhibitor on human retinal pigment epithelium (RPE) cells challenged with 7-ketocholesterol (7-KC) and explored the underlying mechanisms.	7-ketocholesterol	159-176	mechanistic target of rapamycin kinase	Homo sapiens	79-83
34936813-1	2022	Purpose: To validate the protective effect of a mammalian target of rapamycin (mTOR) inhibitor on human retinal pigment epithelium (RPE) cells challenged with 7-ketocholesterol (7-KC) and explored the underlying mechanisms.	7-ketocholesterol	178-182	mechanistic target of rapamycin kinase	Homo sapiens	48-77
34936813-1	2022	Purpose: To validate the protective effect of a mammalian target of rapamycin (mTOR) inhibitor on human retinal pigment epithelium (RPE) cells challenged with 7-ketocholesterol (7-KC) and explored the underlying mechanisms.	7-ketocholesterol	178-182	mechanistic target of rapamycin kinase	Homo sapiens	79-83
34936813-10	2022	Conclusions: Inhibition of mTOR signaling pathway suppressed the elevation of inflammatory cytokines IL-6, IL-8, and the angiogenic agent VEGF induced by 7-KC.	7-ketocholesterol	154-158	interleukin 6	Homo sapiens	101-105
34936813-10	2022	Conclusions: Inhibition of mTOR signaling pathway suppressed the elevation of inflammatory cytokines IL-6, IL-8, and the angiogenic agent VEGF induced by 7-KC.	7-ketocholesterol	154-158	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
34936813-10	2022	Conclusions: Inhibition of mTOR signaling pathway suppressed the elevation of inflammatory cytokines IL-6, IL-8, and the angiogenic agent VEGF induced by 7-KC.	7-ketocholesterol	154-158	vascular endothelial growth factor A	Homo sapiens	138-142
34410548-12	2021	Mechanistically, K-80003 prevented 7-ketocholesterol-induced impairment of autophagic flux in macrophages, evidenced by the decreased LC3II and SQSTM1/p62 expression, GFP-RFP-LC3 cancellation upon K-80003 treatment.	7-ketocholesterol	35-52	sequestosome 1	Mus musculus	144-150
34410548-12	2021	Mechanistically, K-80003 prevented 7-ketocholesterol-induced impairment of autophagic flux in macrophages, evidenced by the decreased LC3II and SQSTM1/p62 expression, GFP-RFP-LC3 cancellation upon K-80003 treatment.	7-ketocholesterol	35-52	sequestosome 1	Mus musculus	151-154
34359916-6	2021	Plaque macrophage content was reduced, which is likely attributable to increased apoptosis, as judged by increased TUNEL+ cells in Pdgfbret/ret plaques (2.1-fold) and increased Pdgfbret/ret macrophage apoptosis upon 7-ketocholesterol or oxidized LDL incubation in vitro.	7-ketocholesterol	216-233	ret proto-oncogene	Mus musculus	186-189
34177581-7	2021	Plasma 7-ketocholesterol (7-KC), an emerging biomarker of NP-C1, was the primary endpoint.	7-ketocholesterol	7-24	NPC intracellular cholesterol transporter 1	Homo sapiens	58-63
35050177-2	2022	We further studied whether CD74 expression is associated with apoptosis in macrophages induced by 7ketocholesterol (7keto).	7-ketocholesterol	98-114	CD74 molecule	Homo sapiens	27-31
35050177-2	2022	We further studied whether CD74 expression is associated with apoptosis in macrophages induced by 7ketocholesterol (7keto).	7-ketocholesterol	116-121	CD74 molecule	Homo sapiens	27-31
3390173-4	1988	These results seem to indicate that 7-ketocholesterol decreases secretion of very low density lipoprotein (VLDL) particles and exerts inhibitory effects on apo-B production at the co-translational or posttranslational level.	7-ketocholesterol	36-53	apolipoprotein B	Homo sapiens	156-161
6833879-4	1983	The activity of cholesterol 7alpha-hydroxylase was also significantly inhibited by 7beta-hydroxycholesterol (38%) and 7-ketocholesterol (35%) at concentrations of 1 micro M, and by 10 micro M 7alpha-hydroxycholesterol (35%), 25alpha-hydroxycholesterol (32%), and 5-cholenic acid-3beta-ol (27%).	7-ketocholesterol	118-135	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	16-46
35234362-8	2022	The ABCG1(-/-) mice HDL exhibited increased accumulation of lipid metabolism-related proteins (e.g., carboxylesterase 1C, apolipoprotein (apo)C-4) and decreased accumulation of alpha-1-antitrypsin, as well as significantly reduced proportion of 7-ketocholesterol.	7-ketocholesterol	245-262	ATP binding cassette subfamily G member 1	Mus musculus	4-9
35234362-9	2022	Additionally, positive correlations were found between 7-ketocholesterol and some essential proteins on HDL, such as alpha-1-antitrypsin, apoA-4, apoB-100, and serum amyloid A (SAA).	7-ketocholesterol	55-72	apolipoprotein A-IV	Mus musculus	138-144
35234362-9	2022	Additionally, positive correlations were found between 7-ketocholesterol and some essential proteins on HDL, such as alpha-1-antitrypsin, apoA-4, apoB-100, and serum amyloid A (SAA).	7-ketocholesterol	55-72	apolipoprotein B	Mus musculus	146-154
35234362-9	2022	Additionally, positive correlations were found between 7-ketocholesterol and some essential proteins on HDL, such as alpha-1-antitrypsin, apoA-4, apoB-100, and serum amyloid A (SAA).	7-ketocholesterol	55-72	serum amyloid A cluster	Mus musculus	160-175
35234362-9	2022	Additionally, positive correlations were found between 7-ketocholesterol and some essential proteins on HDL, such as alpha-1-antitrypsin, apoA-4, apoB-100, and serum amyloid A (SAA).	7-ketocholesterol	55-72	serum amyloid A cluster	Mus musculus	177-180
35409056-0	2022	7-Ketocholesterol-Induced Micro-RNA-107-5p Increases Number and Activity of Osteoclasts by Targeting MKP1.	7-ketocholesterol	0-17	microRNA 107	Mus musculus	26-39
35409056-0	2022	7-Ketocholesterol-Induced Micro-RNA-107-5p Increases Number and Activity of Osteoclasts by Targeting MKP1.	7-ketocholesterol	0-17	dual specificity phosphatase 1	Mus musculus	101-105
35409056-2	2022	We hypothesized that 7-ketocholesterol (7-KC), a metabolite responsible for cholesterol-induced bone loss, induces miR-107-5p, which affects OCs.	7-ketocholesterol	21-38	microRNA 107	Mus musculus	115-122
35409056-2	2022	We hypothesized that 7-ketocholesterol (7-KC), a metabolite responsible for cholesterol-induced bone loss, induces miR-107-5p, which affects OCs.	7-ketocholesterol	40-44	microRNA 107	Mus musculus	115-122
737193-8	1978	These results are interpreted to indicate that 7-ketocholesterol, besides affecting sterol synthesis at the level to 3-hydroxy-3-methylglutaryl coenzyme A reductase, must also affect sterol synthesis at another step further along the synthetic pathway.	7-ketocholesterol	47-64	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	117-164
856284-17	1977	7-Ketocholesterol was shown to induce in C-6 glial cells a rate of decline of HMG-CoA reductase activity compatible with a t 1/2 of just 20 min.	7-ketocholesterol	0-17	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	78-95