PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29283561-3	2018	However, the subsequent 17,20 carbon-carbon scission reaction displays variable substrate specificity in the numerous CYP17A1 isozymes operating in vertebrates, manifesting as different Kd and kcat values when presented with 17alpha-hydroxypregnenlone (OHPREG) versus 17alpha-hydroxyprogesterone (OHPROG).	ohpreg	253-259	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	118-125
29283561-4	2018	Here we show that the identity of the residue at position 202 in human CYP17A1, thought to form a hydrogen bond with the A-ring alcohol substituent on the pregnene- nucleus, is a key driver of this enzyme"s native preference for OHPREG.	ohpreg	229-235	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	71-78
29283561-5	2018	Replacement of asparagine 202 with serine completely reverses the preference of CYP17A1, more than doubling the rate of turnover of the OHPROG to androstenedione reaction and substantially decreasing the rate of formation of dehydroepiandrosterone from OHPREG.	ohpreg	253-259	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	80-87