PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
10996026-7	2000	We revealed that T614 and phenylmethyl sulfonyl fluoride (PMSF), a serine protease inhibitor, inhibited Leu-OME mediated killing of THP-1 cells.	T 614	17-21	GLI family zinc finger 2	Homo sapiens	132-137
12058956-0	2002	An anti-rheumatic agent T-614 inhibits NF-kappaB activation in LPS- and TNF-alpha-stimulated THP-1 cells without interfering with IkappaBalpha degradation.	T 614	24-29	nuclear factor kappa B subunit 1	Homo sapiens	39-48
12058956-0	2002	An anti-rheumatic agent T-614 inhibits NF-kappaB activation in LPS- and TNF-alpha-stimulated THP-1 cells without interfering with IkappaBalpha degradation.	T 614	24-29	tumor necrosis factor	Homo sapiens	72-81
11764202-0	2001	Inhibitory effect of T-614 on tumor necrosis factor-alpha induced cytokine production and nuclear factor-kappaB activation in cultured human synovial cells.	T 614	21-26	tumor necrosis factor	Homo sapiens	30-57
10996026-1	2000	T614 (3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne) is a member of the family of methanesulfonanilide non-steroidal anti-inflammatory drugs (mNSAIDs), most of which act as cyclooxygenase (COX)-2 inhibitors.	T 614	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-218
12470665-6	2002	Taken together, these results suggested that T-614 possessed anabolic effects on bone metabolism, besides suppressor of bone resorption, by increased expression of osterix.	T 614	45-50	Sp7 transcription factor	Homo sapiens	164-171
9726823-2	1998	T-614 dose-dependently suppressed the development of active EAE induced in Lewis rats by immunization with myelin basic protein (MBP) when administered for 2 weeks starting on the day of immunization (day 0 to 14).	T 614	0-5	myelin basic protein	Rattus norvegicus	107-127
9726823-2	1998	T-614 dose-dependently suppressed the development of active EAE induced in Lewis rats by immunization with myelin basic protein (MBP) when administered for 2 weeks starting on the day of immunization (day 0 to 14).	T 614	0-5	myelin basic protein	Rattus norvegicus	129-132
7650864-0	1995	T-614, a novel antirheumatic drug, inhibits both the activity and induction of cyclooxygenase-2 (COX-2) in cultured fibroblasts.	T 614	0-5	prostaglandin-endoperoxide synthase 2	Homo sapiens	79-95
7650864-0	1995	T-614, a novel antirheumatic drug, inhibits both the activity and induction of cyclooxygenase-2 (COX-2) in cultured fibroblasts.	T 614	0-5	prostaglandin-endoperoxide synthase 2	Homo sapiens	97-102
7650864-1	1995	To elucidate the mechanism for the selective inhibition of prostaglandin E2 (PGE2) production in inflammatory tissue by T-614 (3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne), its effects on both the activity and the induction of cyclooxygenase (COX)-2 were investigated in vitro.	T 614	120-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	252-274
7650864-2	1995	T-614 inhibited the activity of purified COX-2 enzyme (IC50: 7.7 micrograms/ml), but was inactive against both COX-1 activities of microsomal and purified enzymes (IC50: > 300 micrograms/ml).	T 614	0-5	prostaglandin-endoperoxide synthase 2	Homo sapiens	41-46
7650864-3	1995	On the other hand, when the inhibition of PGE2 production by T-614 was examined in the cultured fibroblasts stimulated with bradykinin, T-614 at 1 microgram/ml or less inhibited PGE2 release more effectively than that in the above cell-free system.	T 614	61-66	kininogen 1	Homo sapiens	124-134
7650864-7	1995	These studies suggest that at least some of inhibitory effects of T-614 on prostanoids production are mediated by the synergy of the inhibition of COX-2 activity and the inhibition of induction, and such an action of T-614 may explain the pharmacological properties of this drug.	T 614	66-71	prostaglandin-endoperoxide synthase 2	Homo sapiens	147-152
1289500-3	1992	T-614 inhibited the release of immunoreactive IL-1 beta from these cells stimulated with lipopolysaccharides (LPS) in a dose-dependent manner (0.3-30 micrograms/ml).	T 614	0-5	interleukin 1 beta	Homo sapiens	46-55
1289500-5	1992	Northern blotting analysis using LPS-stimulated THP-1 cells indicated that the inhibitory effect of T-614 on IL-1 beta production is caused by the suppression of IL-1 beta mRNA expression.	T 614	100-105	interleukin 1 beta	Homo sapiens	109-118
1289500-5	1992	Northern blotting analysis using LPS-stimulated THP-1 cells indicated that the inhibitory effect of T-614 on IL-1 beta production is caused by the suppression of IL-1 beta mRNA expression.	T 614	100-105	interleukin 1 beta	Homo sapiens	162-171
29670900-10	2018	The results showed that T-614 promotes osteoblastic differentiation by increasing the expression of Osterix and Dlx5 and increasing the activation of P38.	T 614	24-29	Sp7 transcription factor	Homo sapiens	100-107
29670900-10	2018	The results showed that T-614 promotes osteoblastic differentiation by increasing the expression of Osterix and Dlx5 and increasing the activation of P38.	T 614	24-29	distal-less homeobox 5	Homo sapiens	112-116
29670900-10	2018	The results showed that T-614 promotes osteoblastic differentiation by increasing the expression of Osterix and Dlx5 and increasing the activation of P38.	T 614	24-29	mitogen-activated protein kinase 14	Homo sapiens	150-153
22446297-6	2012	Levels of MMP-1 and MMP-3 were decreased significantly after 24 week treatment of T-614 group 2 or MTX group.	T 614	82-87	matrix metallopeptidase 1	Homo sapiens	10-15
22446297-6	2012	Levels of MMP-1 and MMP-3 were decreased significantly after 24 week treatment of T-614 group 2 or MTX group.	T 614	82-87	matrix metallopeptidase 3	Homo sapiens	20-25
22446297-12	2012	These results suggest that T-614 inhibits the invasiveness through decreasing the MMP-1 and MMP-3 production.	T 614	27-32	matrix metallopeptidase 1	Homo sapiens	82-87
22446297-12	2012	These results suggest that T-614 inhibits the invasiveness through decreasing the MMP-1 and MMP-3 production.	T 614	27-32	matrix metallopeptidase 3	Homo sapiens	92-97
17334666-7	2007	RESULTS: Administration of T-614 did not inhibit the tumor growth, but it resulted in attenuation of cachexia symptoms, such as the reduction in epididymal fat and gastrocnemius muscle, and the decrease of serum albumin.	T 614	27-32	albumin	Mus musculus	206-219
26273599-4	2015	We confirmed this effect by a decrease of the mRNA and protein RANKL and mRNA RANKL/OPG in RASFs exposed in vitro to T-614 or MTX.	T 614	117-122	TNF superfamily member 11	Homo sapiens	63-68
26273599-4	2015	We confirmed this effect by a decrease of the mRNA and protein RANKL and mRNA RANKL/OPG in RASFs exposed in vitro to T-614 or MTX.	T 614	117-122	TNF superfamily member 11	Homo sapiens	78-83
26273599-4	2015	We confirmed this effect by a decrease of the mRNA and protein RANKL and mRNA RANKL/OPG in RASFs exposed in vitro to T-614 or MTX.	T 614	117-122	TNF receptor superfamily member 11b	Homo sapiens	84-87
26273599-5	2015	Markedly decreased levels of IL-17, retinoid-related orphan receptor C (RORc), and MMP-3 mRNA expression were also observed in IL-6-induced RASFs in the presence of T-614 or MTX compared with those in its absence.	T 614	165-170	interleukin 17A	Homo sapiens	29-34
26273599-5	2015	Markedly decreased levels of IL-17, retinoid-related orphan receptor C (RORc), and MMP-3 mRNA expression were also observed in IL-6-induced RASFs in the presence of T-614 or MTX compared with those in its absence.	T 614	165-170	RAR related orphan receptor C	Homo sapiens	36-70
26273599-5	2015	Markedly decreased levels of IL-17, retinoid-related orphan receptor C (RORc), and MMP-3 mRNA expression were also observed in IL-6-induced RASFs in the presence of T-614 or MTX compared with those in its absence.	T 614	165-170	RAR related orphan receptor C	Homo sapiens	72-76
26273599-5	2015	Markedly decreased levels of IL-17, retinoid-related orphan receptor C (RORc), and MMP-3 mRNA expression were also observed in IL-6-induced RASFs in the presence of T-614 or MTX compared with those in its absence.	T 614	165-170	matrix metallopeptidase 3	Homo sapiens	83-88
26273599-5	2015	Markedly decreased levels of IL-17, retinoid-related orphan receptor C (RORc), and MMP-3 mRNA expression were also observed in IL-6-induced RASFs in the presence of T-614 or MTX compared with those in its absence.	T 614	165-170	interleukin 6	Homo sapiens	127-131
19019215-14	2008	In addition, T-614 (20 mg/kg per day) depressed production of anti-type II collagen antibodies and differentially affected levels of IgG2a subclasses in vivo, whereas IgM level was decreased without any change in the IgG1 level.	T 614	13-18	gamma-2a immunoglobulin heavy chain	Rattus norvegicus	133-138
16848314-8	2006	CONCLUSION: The inhibitory effect of T-614 on the production of TNFalpha in LPS-stimulated NR8383 cells may be mediated by suppression of NF-kappaB activity.	T 614	37-42	tumor necrosis factor	Rattus norvegicus	64-72