PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33957471-6 2021 Additionally, BT/CS-TiO2 heterostructured showed satisfactory recyclability with no considerable interferences in the presence of coexisting anions due to the suitability of the valence band position of TiO2 for the oxidation of AsIII as well as the presence of CS into BT layers. asiii 229-234 citrate synthase Homo sapiens 17-19 3236342-6 1988 The main effects of continuous exposure to AsIII were an initial decrease in the heme saturation of TP, which remained constant during the period of treatment, and an initial increase in ALAS activity, which after ten days of exposure dropped somewhat but remained above control values. asiii 43-48 tryptophan 2,3-dioxygenase Rattus norvegicus 100-102 3236342-6 1988 The main effects of continuous exposure to AsIII were an initial decrease in the heme saturation of TP, which remained constant during the period of treatment, and an initial increase in ALAS activity, which after ten days of exposure dropped somewhat but remained above control values. asiii 43-48 5'-aminolevulinate synthase 1 Rattus norvegicus 187-191 30716544-3 2019 The adsorption envelopes reveal that the adsorption of TAsIII on alpha-Fe2O3 is significantly less than that of arsenite (AsIII) in the pH range from 7 to 11 with the initial As concentration of 25 mg L-1. asiii 56-61 L1 cell adhesion molecule Homo sapiens 201-204 32810714-6 2021 Modulated spatio-temporal expression of various TaCAT genes and alteration in total catalase enzyme activity during heat, drought, salt and arsenic (AsIII and AsV) treatment suggested their roles in abiotic stress response and arsenic tolerance. asiii 149-154 catalase-1 Triticum aestivum 48-53 32014725-4 2020 In the present study, a chickpea glutaredoxin (CaGrx) gene (LOC101493651) has been investigated against metal stress based on its primary screening in chickpea which revealed higher up-regulation of CaGrx gene under various heavy metals (AsIII-25 muM, AsV-250 muM, Cr(VI)-300 muM, and Cd-500 muM) stress. asiii 238-243 glutaredoxin Cicer arietinum 33-45 31408795-3 2019 Furthermore, low concentrations of AsIII exposure caused oxidative stress (elevated superoxide dismutase (SOD) activity and influenced the mRNA transcriptional levels of Cu/ZnSOD and MnSOD) and damage (increased malondialdehyde levels). asiii 35-40 superoxide dismutase 1, soluble Danio rerio 106-109 31408795-3 2019 Furthermore, low concentrations of AsIII exposure caused oxidative stress (elevated superoxide dismutase (SOD) activity and influenced the mRNA transcriptional levels of Cu/ZnSOD and MnSOD) and damage (increased malondialdehyde levels). asiii 35-40 superoxide dismutase 1, soluble Danio rerio 170-178 31408795-3 2019 Furthermore, low concentrations of AsIII exposure caused oxidative stress (elevated superoxide dismutase (SOD) activity and influenced the mRNA transcriptional levels of Cu/ZnSOD and MnSOD) and damage (increased malondialdehyde levels). asiii 35-40 superoxide dismutase 2, mitochondrial Danio rerio 183-188 31152818-2 2019 The zinc finger DNA repair protein Poly (ADP-ribose) polymerase 1 (PARP-1) is a sensitive target of AsIII and both reactive oxygen and nitrogen species (ROS/RNS) generated by AsIII contribute to PARP-1 inhibition. asiii 100-105 poly(ADP-ribose) polymerase 1 Homo sapiens 67-73 33740714-1 2021 Arsenite (AsIII) antiporter ACR3 is crucial for arsenic (As) translocation and sequestration in As-hyperaccumulator Pteris vittata, which has potential for phytoremediation of As-contaminated soils. asiii 10-15 Arr3p Saccharomyces cerevisiae S288C 28-32 33740714-3 2021 Both ACR3s mediated AsIII efflux in yeast, decreasing its As accumulation and enhancing its As tolerance. asiii 20-25 Arr3p Saccharomyces cerevisiae S288C 5-9 32464441-3 2020 We found that AsIII increased the activities of CAT by 46%-87%, decreased the activities of SOD and the contents of MDA by 19% and 21%-32%. asiii 14-19 catalase Danio rerio 48-51 28798983-9 2017 AQP9 transport of MSeA, selenite and lactate is all inhibited by a previously identified AQP9 inhibitor, phloretin, and the AQP9 substrate arsenite (AsIII). asiii 149-154 aquaporin 9 Homo sapiens 0-4 30664189-9 2019 These cumulative data support the hypothesis that exposure to AsIII may contribute to reducing the efficacy of endocrine therapy against ERalpha-positive breast tumors by hampering the expression of ERalpha and BRCA1 via CpG methylation, respectively of ESR1 and BRCA1. asiii 62-67 estrogen receptor 1 Homo sapiens 137-144 30664189-9 2019 These cumulative data support the hypothesis that exposure to AsIII may contribute to reducing the efficacy of endocrine therapy against ERalpha-positive breast tumors by hampering the expression of ERalpha and BRCA1 via CpG methylation, respectively of ESR1 and BRCA1. asiii 62-67 estrogen receptor 1 Homo sapiens 199-206 30664189-9 2019 These cumulative data support the hypothesis that exposure to AsIII may contribute to reducing the efficacy of endocrine therapy against ERalpha-positive breast tumors by hampering the expression of ERalpha and BRCA1 via CpG methylation, respectively of ESR1 and BRCA1. asiii 62-67 BRCA1 DNA repair associated Homo sapiens 211-216 30664189-9 2019 These cumulative data support the hypothesis that exposure to AsIII may contribute to reducing the efficacy of endocrine therapy against ERalpha-positive breast tumors by hampering the expression of ERalpha and BRCA1 via CpG methylation, respectively of ESR1 and BRCA1. asiii 62-67 estrogen receptor 1 Homo sapiens 254-258 30664189-9 2019 These cumulative data support the hypothesis that exposure to AsIII may contribute to reducing the efficacy of endocrine therapy against ERalpha-positive breast tumors by hampering the expression of ERalpha and BRCA1 via CpG methylation, respectively of ESR1 and BRCA1. asiii 62-67 BRCA1 DNA repair associated Homo sapiens 263-268 29572906-5 2018 EGCG was effective not only in reducing AsIII-induced nuclear expression of Nrf2 and Nrf2Ser40 but also in increasing nuclear expression of Keap1 both at protein and mRNA level. asiii 40-45 NFE2 like bZIP transcription factor 2 Homo sapiens 76-80 29572906-5 2018 EGCG was effective not only in reducing AsIII-induced nuclear expression of Nrf2 and Nrf2Ser40 but also in increasing nuclear expression of Keap1 both at protein and mRNA level. asiii 40-45 NFE2 like bZIP transcription factor 2 Homo sapiens 85-89 29572906-8 2018 EGCG along with AsIII caused decreased phosphorylation of Nrf2 at ser40 residue, which might have facilitated Keap1-mediated nuclear export and degradation of Nrf2 and paved the pro-survival signal for AsIII-insulted HaCaT cells. asiii 16-21 NFE2 like bZIP transcription factor 2 Homo sapiens 58-62 29572906-8 2018 EGCG along with AsIII caused decreased phosphorylation of Nrf2 at ser40 residue, which might have facilitated Keap1-mediated nuclear export and degradation of Nrf2 and paved the pro-survival signal for AsIII-insulted HaCaT cells. asiii 16-21 kelch like ECH associated protein 1 Homo sapiens 110-115 29572906-8 2018 EGCG along with AsIII caused decreased phosphorylation of Nrf2 at ser40 residue, which might have facilitated Keap1-mediated nuclear export and degradation of Nrf2 and paved the pro-survival signal for AsIII-insulted HaCaT cells. asiii 16-21 NFE2 like bZIP transcription factor 2 Homo sapiens 159-163 29572906-9 2018 In conclusion, it might be indicated that EGCG in spite of inducing the pro-oxidant effect was effective in increasing the viability of AsIII-treated HaCaT cells by partially restoring the Nrf2/Keap1-mediated signaling axis. asiii 136-141 NFE2 like bZIP transcription factor 2 Homo sapiens 189-193 29572906-9 2018 In conclusion, it might be indicated that EGCG in spite of inducing the pro-oxidant effect was effective in increasing the viability of AsIII-treated HaCaT cells by partially restoring the Nrf2/Keap1-mediated signaling axis. asiii 136-141 kelch like ECH associated protein 1 Homo sapiens 194-199 28798983-9 2017 AQP9 transport of MSeA, selenite and lactate is all inhibited by a previously identified AQP9 inhibitor, phloretin, and the AQP9 substrate arsenite (AsIII). asiii 149-154 aquaporin 9 Homo sapiens 89-93 28798983-9 2017 AQP9 transport of MSeA, selenite and lactate is all inhibited by a previously identified AQP9 inhibitor, phloretin, and the AQP9 substrate arsenite (AsIII). asiii 149-154 aquaporin 9 Homo sapiens 89-93 27741521-2 2016 Our recent work suggests that reactive oxygen/nitrogen species (ROS/RNS) induced by arsenite (AsIII) play an important role in the inhibition of the DNA repair protein Poly(ADP-ribose) polymerase 1 (PARP-1). asiii 94-99 poly(ADP-ribose) polymerase 1 Homo sapiens 168-197 27741521-2 2016 Our recent work suggests that reactive oxygen/nitrogen species (ROS/RNS) induced by arsenite (AsIII) play an important role in the inhibition of the DNA repair protein Poly(ADP-ribose) polymerase 1 (PARP-1). asiii 94-99 poly(ADP-ribose) polymerase 1 Homo sapiens 199-205 27741521-5 2016 In this work, we demonstrate that AsIII treatment of normal human keratinocyte (HEKn) cells induced S-nitrosation on cysteine residues of PARP-1 protein, in a similar manner to a nitric oxide donor. asiii 34-39 poly(ADP-ribose) polymerase 1 Homo sapiens 138-144 27741521-10 2016 Taken together, AsIII induces S-nitrosation on PARP-1 zinc finger DNA binding domain by generating NO through iNOS activation, leading to zinc loss and inhibition of PARP-1 activity, thereby increasing retention of damaged DNA. asiii 16-21 poly(ADP-ribose) polymerase 1 Homo sapiens 47-53 27741521-10 2016 Taken together, AsIII induces S-nitrosation on PARP-1 zinc finger DNA binding domain by generating NO through iNOS activation, leading to zinc loss and inhibition of PARP-1 activity, thereby increasing retention of damaged DNA. asiii 16-21 poly(ADP-ribose) polymerase 1 Homo sapiens 166-172 20457661-4 2010 To test this hypothesis, we first examined whether the RNA-cleaving enzyme polynucleotide phosphorylase (PNPase), which can split poly-adenylate (poly-A) by arsenolysis into units of AMP-AsV (a homologue of ADP-AsV), could also promote reduction of AsV to AsIII in presence of thiols. asiii 256-261 polyribonucleotide nucleotidyltransferase 1 Homo sapiens 75-103 28713220-10 2016 Finally, both SbIII and AsIII were seen to attenuate bone morphogenetic protein 6 induction of dual specificity phosphatases 2 and 14, consistent with maintaining epidermal growth factor receptor signaling. asiii 24-29 epidermal growth factor receptor Homo sapiens 163-195 26823637-4 2015 The results of shaken batch bioassays indicated that the original, unexposed sludge was severely inhibited by arsenite (AsIII) as evidenced by the low 50% inhibition concentrations (IC50) determined, i.e., 19 and 90 muM for acetoclastic- and hydrogenotrophic methanogenesis, respectively. asiii 120-125 latexin Homo sapiens 216-219 26823637-5 2015 The tolerance of the acetoclastic and hydrogenotrophic methanogens in the sludge to AsIII increased 47-fold (IC50 = 910 muM) and 12-fold (IC50= 1100 muM), respectively, upon long-term exposure to As. asiii 84-89 latexin Homo sapiens 120-123 26823637-5 2015 The tolerance of the acetoclastic and hydrogenotrophic methanogens in the sludge to AsIII increased 47-fold (IC50 = 910 muM) and 12-fold (IC50= 1100 muM), respectively, upon long-term exposure to As. asiii 84-89 latexin Homo sapiens 149-152 20457661-4 2010 To test this hypothesis, we first examined whether the RNA-cleaving enzyme polynucleotide phosphorylase (PNPase), which can split poly-adenylate (poly-A) by arsenolysis into units of AMP-AsV (a homologue of ADP-AsV), could also promote reduction of AsV to AsIII in presence of thiols. asiii 256-261 polyribonucleotide nucleotidyltransferase 1 Homo sapiens 105-111 20457661-5 2010 Indeed, bacterial PNPase markedly facilitated formation of AsIII when incubated with poly-A, AsV, and GSH. asiii 59-64 polyribonucleotide nucleotidyltransferase 1 Homo sapiens 18-24 18435919-3 2008 AtNIP7;1 expression in various yeast backgrounds increased AsIII sensitivity. asiii 59-64 NOD26-like intrinsic protein 7;1 Arabidopsis thaliana 0-8 19248796-1 2009 Three cytosolic phosphorolytic/arsenolytic enzymes, (purine nucleoside phosphorylase [PNP], glycogen phosphorylase, glyceraldehyde-3-phosphate dehydrogenase) have been shown to mediate reduction of arsenate (AsV) to the more toxic arsenite (AsIII) in a thiol-dependent manner. asiii 241-246 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 116-156 19478237-6 2009 In presence of inosine, AsV and DTT, PNP mediates AsIII formation. asiii 50-55 purine nucleoside phosphorylase Homo sapiens 37-40 19478237-8 2009 Despite inhibition of PNP, large amount of AsIII was formed in these incubations, indicating that PNP does not reduce AsV directly but forms a product (i.e., ribose-1-arsenate) that is reduced to AsIII by DTT. asiii 43-48 purine nucleoside phosphorylase Homo sapiens 98-101 18435919-6 2008 The data suggest that AtNIP7;1 can mediate AsIII transport and contributes to AsIII uptake in plants. asiii 43-48 NOD26-like intrinsic protein 7;1 Arabidopsis thaliana 22-30 18435919-6 2008 The data suggest that AtNIP7;1 can mediate AsIII transport and contributes to AsIII uptake in plants. asiii 78-83 NOD26-like intrinsic protein 7;1 Arabidopsis thaliana 22-30 15788719-11 2005 In conclusion, the key glycolytic enzyme GAPDH can fortuitously catalyze the reduction of AsV to AsIII, if GSH, NAD, and glycolytic substrate are available. asiii 97-102 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 41-46 12388830-9 2002 (3) PNP purified from calf spleen catalyzed reduction of AsV to AsIII in the presence of dithiothreitol (DTT) and a 6-oxopurine nucleoside (guanosine or inosine). asiii 64-69 purine nucleoside phosphorylase Bos taurus 4-7 15089098-3 2004 The current study examined the hypothesis that low, environmentally relevant levels of trivalent arsenic (AsIII) activate discrete signaling pathways in vascular smooth muscle cells (SMC) to induce expression of VEGF. asiii 106-111 vascular endothelial growth factor A Homo sapiens 212-216 15089098-7 2004 However, unlike the response to an iron chelator, AsIII-induced VEGF was not inhibited by siRNA directed toward HIF-1alpha. asiii 50-55 vascular endothelial growth factor A Homo sapiens 64-68 15089098-10 2004 These data suggest that AsIII induced divergent signaling pathways in SMCs that lead to independent increases in VEGF expression and HIF-1alpha signaling. asiii 24-29 vascular endothelial growth factor A Homo sapiens 113-117 15089098-10 2004 These data suggest that AsIII induced divergent signaling pathways in SMCs that lead to independent increases in VEGF expression and HIF-1alpha signaling. asiii 24-29 hypoxia inducible factor 1 subunit alpha Homo sapiens 133-143 34697490-2 2021 Here, building from our clinical discovery that cancerous cells from patients with different leukaemia forms featured stable and strong expression of CD71, we designed a ferritin-based As nanomedicine, As@Fn, that bound to leukaemia cells with very high affinity, and efficiently delivered cytotoxic AsIII into a large diversity of leukaemia cell lines and patient cells. asiii 300-305 transferrin receptor Homo sapiens 150-154