PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19478237-8	2009	Despite inhibition of PNP, large amount of AsIII was formed in these incubations, indicating that PNP does not reduce AsV directly but forms a product (i.e., ribose-1-arsenate) that is reduced to AsIII by DTT.	asiii	43-48	purine nucleoside phosphorylase	Homo sapiens	98-101
19478237-6	2009	In presence of inosine, AsV and DTT, PNP mediates AsIII formation.	asiii	50-55	purine nucleoside phosphorylase	Homo sapiens	37-40
20457661-4	2010	To test this hypothesis, we first examined whether the RNA-cleaving enzyme polynucleotide phosphorylase (PNPase), which can split poly-adenylate (poly-A) by arsenolysis into units of AMP-AsV (a homologue of ADP-AsV), could also promote reduction of AsV to AsIII in presence of thiols.	asiii	256-261	polyribonucleotide nucleotidyltransferase 1	Homo sapiens	75-103
20457661-4	2010	To test this hypothesis, we first examined whether the RNA-cleaving enzyme polynucleotide phosphorylase (PNPase), which can split poly-adenylate (poly-A) by arsenolysis into units of AMP-AsV (a homologue of ADP-AsV), could also promote reduction of AsV to AsIII in presence of thiols.	asiii	256-261	polyribonucleotide nucleotidyltransferase 1	Homo sapiens	105-111
20457661-5	2010	Indeed, bacterial PNPase markedly facilitated formation of AsIII when incubated with poly-A, AsV, and GSH.	asiii	59-64	polyribonucleotide nucleotidyltransferase 1	Homo sapiens	18-24
19248796-1	2009	Three cytosolic phosphorolytic/arsenolytic enzymes, (purine nucleoside phosphorylase [PNP], glycogen phosphorylase, glyceraldehyde-3-phosphate dehydrogenase) have been shown to mediate reduction of arsenate (AsV) to the more toxic arsenite (AsIII) in a thiol-dependent manner.	asiii	241-246	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	116-156
34697490-2	2021	Here, building from our clinical discovery that cancerous cells from patients with different leukaemia forms featured stable and strong expression of CD71, we designed a ferritin-based As nanomedicine, As@Fn, that bound to leukaemia cells with very high affinity, and efficiently delivered cytotoxic AsIII into a large diversity of leukaemia cell lines and patient cells.	asiii	300-305	transferrin receptor	Homo sapiens	150-154
18435919-3	2008	AtNIP7;1 expression in various yeast backgrounds increased AsIII sensitivity.	asiii	59-64	NOD26-like intrinsic protein 7;1	Arabidopsis thaliana	0-8
18435919-6	2008	The data suggest that AtNIP7;1 can mediate AsIII transport and contributes to AsIII uptake in plants.	asiii	43-48	NOD26-like intrinsic protein 7;1	Arabidopsis thaliana	22-30
18435919-6	2008	The data suggest that AtNIP7;1 can mediate AsIII transport and contributes to AsIII uptake in plants.	asiii	78-83	NOD26-like intrinsic protein 7;1	Arabidopsis thaliana	22-30
15089098-3	2004	The current study examined the hypothesis that low, environmentally relevant levels of trivalent arsenic (AsIII) activate discrete signaling pathways in vascular smooth muscle cells (SMC) to induce expression of VEGF.	asiii	106-111	vascular endothelial growth factor A	Homo sapiens	212-216
15089098-7	2004	However, unlike the response to an iron chelator, AsIII-induced VEGF was not inhibited by siRNA directed toward HIF-1alpha.	asiii	50-55	vascular endothelial growth factor A	Homo sapiens	64-68
15089098-10	2004	These data suggest that AsIII induced divergent signaling pathways in SMCs that lead to independent increases in VEGF expression and HIF-1alpha signaling.	asiii	24-29	vascular endothelial growth factor A	Homo sapiens	113-117
15089098-10	2004	These data suggest that AsIII induced divergent signaling pathways in SMCs that lead to independent increases in VEGF expression and HIF-1alpha signaling.	asiii	24-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-143
15788719-11	2005	In conclusion, the key glycolytic enzyme GAPDH can fortuitously catalyze the reduction of AsV to AsIII, if GSH, NAD, and glycolytic substrate are available.	asiii	97-102	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	41-46
12388830-9	2002	(3) PNP purified from calf spleen catalyzed reduction of AsV to AsIII in the presence of dithiothreitol (DTT) and a 6-oxopurine nucleoside (guanosine or inosine).	asiii	64-69	purine nucleoside phosphorylase	Bos taurus	4-7
32464441-3	2020	We found that AsIII increased the activities of CAT by 46%-87%, decreased the activities of SOD and the contents of MDA by 19% and 21%-32%.	asiii	14-19	catalase	Danio rerio	48-51
3236342-6	1988	The main effects of continuous exposure to AsIII were an initial decrease in the heme saturation of TP, which remained constant during the period of treatment, and an initial increase in ALAS activity, which after ten days of exposure dropped somewhat but remained above control values.	asiii	43-48	tryptophan 2,3-dioxygenase	Rattus norvegicus	100-102
3236342-6	1988	The main effects of continuous exposure to AsIII were an initial decrease in the heme saturation of TP, which remained constant during the period of treatment, and an initial increase in ALAS activity, which after ten days of exposure dropped somewhat but remained above control values.	asiii	43-48	5'-aminolevulinate synthase 1	Rattus norvegicus	187-191
33957471-6	2021	Additionally, BT/CS-TiO2 heterostructured showed satisfactory recyclability with no considerable interferences in the presence of coexisting anions due to the suitability of the valence band position of TiO2 for the oxidation of AsIII as well as the presence of CS into BT layers.	asiii	229-234	citrate synthase	Homo sapiens	17-19
33740714-1	2021	Arsenite (AsIII) antiporter ACR3 is crucial for arsenic (As) translocation and sequestration in As-hyperaccumulator Pteris vittata, which has potential for phytoremediation of As-contaminated soils.	asiii	10-15	Arr3p	Saccharomyces cerevisiae S288C	28-32
33740714-3	2021	Both ACR3s mediated AsIII efflux in yeast, decreasing its As accumulation and enhancing its As tolerance.	asiii	20-25	Arr3p	Saccharomyces cerevisiae S288C	5-9
32810714-6	2021	Modulated spatio-temporal expression of various TaCAT genes and alteration in total catalase enzyme activity during heat, drought, salt and arsenic (AsIII and AsV) treatment suggested their roles in abiotic stress response and arsenic tolerance.	asiii	149-154	catalase-1	Triticum aestivum	48-53
31408795-3	2019	Furthermore, low concentrations of AsIII exposure caused oxidative stress (elevated superoxide dismutase (SOD) activity and influenced the mRNA transcriptional levels of Cu/ZnSOD and MnSOD) and damage (increased malondialdehyde levels).	asiii	35-40	superoxide dismutase 1, soluble	Danio rerio	106-109
31408795-3	2019	Furthermore, low concentrations of AsIII exposure caused oxidative stress (elevated superoxide dismutase (SOD) activity and influenced the mRNA transcriptional levels of Cu/ZnSOD and MnSOD) and damage (increased malondialdehyde levels).	asiii	35-40	superoxide dismutase 1, soluble	Danio rerio	170-178
31408795-3	2019	Furthermore, low concentrations of AsIII exposure caused oxidative stress (elevated superoxide dismutase (SOD) activity and influenced the mRNA transcriptional levels of Cu/ZnSOD and MnSOD) and damage (increased malondialdehyde levels).	asiii	35-40	superoxide dismutase 2, mitochondrial	Danio rerio	183-188
28713220-10	2016	Finally, both SbIII and AsIII were seen to attenuate bone morphogenetic protein 6 induction of dual specificity phosphatases 2 and 14, consistent with maintaining epidermal growth factor receptor signaling.	asiii	24-29	epidermal growth factor receptor	Homo sapiens	163-195
32014725-4	2020	In the present study, a chickpea glutaredoxin (CaGrx) gene (LOC101493651) has been investigated against metal stress based on its primary screening in chickpea which revealed higher up-regulation of CaGrx gene under various heavy metals (AsIII-25 muM, AsV-250 muM, Cr(VI)-300 muM, and Cd-500 muM) stress.	asiii	238-243	glutaredoxin	Cicer arietinum	33-45
31152818-2	2019	The zinc finger DNA repair protein Poly (ADP-ribose) polymerase 1 (PARP-1) is a sensitive target of AsIII and both reactive oxygen and nitrogen species (ROS/RNS) generated by AsIII contribute to PARP-1 inhibition.	asiii	100-105	poly(ADP-ribose) polymerase 1	Homo sapiens	67-73
30716544-3	2019	The adsorption envelopes reveal that the adsorption of TAsIII on alpha-Fe2O3 is significantly less than that of arsenite (AsIII) in the pH range from 7 to 11 with the initial As concentration of 25 mg L-1.	asiii	56-61	L1 cell adhesion molecule	Homo sapiens	201-204
30664189-9	2019	These cumulative data support the hypothesis that exposure to AsIII may contribute to reducing the efficacy of endocrine therapy against ERalpha-positive breast tumors by hampering the expression of ERalpha and BRCA1 via CpG methylation, respectively of ESR1 and BRCA1.	asiii	62-67	estrogen receptor 1	Homo sapiens	137-144
30664189-9	2019	These cumulative data support the hypothesis that exposure to AsIII may contribute to reducing the efficacy of endocrine therapy against ERalpha-positive breast tumors by hampering the expression of ERalpha and BRCA1 via CpG methylation, respectively of ESR1 and BRCA1.	asiii	62-67	estrogen receptor 1	Homo sapiens	199-206
30664189-9	2019	These cumulative data support the hypothesis that exposure to AsIII may contribute to reducing the efficacy of endocrine therapy against ERalpha-positive breast tumors by hampering the expression of ERalpha and BRCA1 via CpG methylation, respectively of ESR1 and BRCA1.	asiii	62-67	BRCA1 DNA repair associated	Homo sapiens	211-216
30664189-9	2019	These cumulative data support the hypothesis that exposure to AsIII may contribute to reducing the efficacy of endocrine therapy against ERalpha-positive breast tumors by hampering the expression of ERalpha and BRCA1 via CpG methylation, respectively of ESR1 and BRCA1.	asiii	62-67	estrogen receptor 1	Homo sapiens	254-258
30664189-9	2019	These cumulative data support the hypothesis that exposure to AsIII may contribute to reducing the efficacy of endocrine therapy against ERalpha-positive breast tumors by hampering the expression of ERalpha and BRCA1 via CpG methylation, respectively of ESR1 and BRCA1.	asiii	62-67	BRCA1 DNA repair associated	Homo sapiens	263-268
29572906-5	2018	EGCG was effective not only in reducing AsIII-induced nuclear expression of Nrf2 and Nrf2Ser40 but also in increasing nuclear expression of Keap1 both at protein and mRNA level.	asiii	40-45	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
29572906-5	2018	EGCG was effective not only in reducing AsIII-induced nuclear expression of Nrf2 and Nrf2Ser40 but also in increasing nuclear expression of Keap1 both at protein and mRNA level.	asiii	40-45	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
29572906-8	2018	EGCG along with AsIII caused decreased phosphorylation of Nrf2 at ser40 residue, which might have facilitated Keap1-mediated nuclear export and degradation of Nrf2 and paved the pro-survival signal for AsIII-insulted HaCaT cells.	asiii	16-21	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
29572906-8	2018	EGCG along with AsIII caused decreased phosphorylation of Nrf2 at ser40 residue, which might have facilitated Keap1-mediated nuclear export and degradation of Nrf2 and paved the pro-survival signal for AsIII-insulted HaCaT cells.	asiii	16-21	kelch like ECH associated protein 1	Homo sapiens	110-115
29572906-8	2018	EGCG along with AsIII caused decreased phosphorylation of Nrf2 at ser40 residue, which might have facilitated Keap1-mediated nuclear export and degradation of Nrf2 and paved the pro-survival signal for AsIII-insulted HaCaT cells.	asiii	16-21	NFE2 like bZIP transcription factor 2	Homo sapiens	159-163
29572906-9	2018	In conclusion, it might be indicated that EGCG in spite of inducing the pro-oxidant effect was effective in increasing the viability of AsIII-treated HaCaT cells by partially restoring the Nrf2/Keap1-mediated signaling axis.	asiii	136-141	NFE2 like bZIP transcription factor 2	Homo sapiens	189-193
29572906-9	2018	In conclusion, it might be indicated that EGCG in spite of inducing the pro-oxidant effect was effective in increasing the viability of AsIII-treated HaCaT cells by partially restoring the Nrf2/Keap1-mediated signaling axis.	asiii	136-141	kelch like ECH associated protein 1	Homo sapiens	194-199
28798983-9	2017	AQP9 transport of MSeA, selenite and lactate is all inhibited by a previously identified AQP9 inhibitor, phloretin, and the AQP9 substrate arsenite (AsIII).	asiii	149-154	aquaporin 9	Homo sapiens	0-4
28798983-9	2017	AQP9 transport of MSeA, selenite and lactate is all inhibited by a previously identified AQP9 inhibitor, phloretin, and the AQP9 substrate arsenite (AsIII).	asiii	149-154	aquaporin 9	Homo sapiens	89-93
28798983-9	2017	AQP9 transport of MSeA, selenite and lactate is all inhibited by a previously identified AQP9 inhibitor, phloretin, and the AQP9 substrate arsenite (AsIII).	asiii	149-154	aquaporin 9	Homo sapiens	89-93
27741521-2	2016	Our recent work suggests that reactive oxygen/nitrogen species (ROS/RNS) induced by arsenite (AsIII) play an important role in the inhibition of the DNA repair protein Poly(ADP-ribose) polymerase 1 (PARP-1).	asiii	94-99	poly(ADP-ribose) polymerase 1	Homo sapiens	168-197
27741521-2	2016	Our recent work suggests that reactive oxygen/nitrogen species (ROS/RNS) induced by arsenite (AsIII) play an important role in the inhibition of the DNA repair protein Poly(ADP-ribose) polymerase 1 (PARP-1).	asiii	94-99	poly(ADP-ribose) polymerase 1	Homo sapiens	199-205
27741521-5	2016	In this work, we demonstrate that AsIII treatment of normal human keratinocyte (HEKn) cells induced S-nitrosation on cysteine residues of PARP-1 protein, in a similar manner to a nitric oxide donor.	asiii	34-39	poly(ADP-ribose) polymerase 1	Homo sapiens	138-144
27741521-10	2016	Taken together, AsIII induces S-nitrosation on PARP-1 zinc finger DNA binding domain by generating NO through iNOS activation, leading to zinc loss and inhibition of PARP-1 activity, thereby increasing retention of damaged DNA.	asiii	16-21	poly(ADP-ribose) polymerase 1	Homo sapiens	47-53
27741521-10	2016	Taken together, AsIII induces S-nitrosation on PARP-1 zinc finger DNA binding domain by generating NO through iNOS activation, leading to zinc loss and inhibition of PARP-1 activity, thereby increasing retention of damaged DNA.	asiii	16-21	poly(ADP-ribose) polymerase 1	Homo sapiens	166-172
26823637-4	2015	The results of shaken batch bioassays indicated that the original, unexposed sludge was severely inhibited by arsenite (AsIII) as evidenced by the low 50% inhibition concentrations (IC50) determined, i.e., 19 and 90 muM for acetoclastic- and hydrogenotrophic methanogenesis, respectively.	asiii	120-125	latexin	Homo sapiens	216-219
26823637-5	2015	The tolerance of the acetoclastic and hydrogenotrophic methanogens in the sludge to AsIII increased 47-fold (IC50 = 910 muM) and 12-fold (IC50= 1100 muM), respectively, upon long-term exposure to As.	asiii	84-89	latexin	Homo sapiens	120-123
26823637-5	2015	The tolerance of the acetoclastic and hydrogenotrophic methanogens in the sludge to AsIII increased 47-fold (IC50 = 910 muM) and 12-fold (IC50= 1100 muM), respectively, upon long-term exposure to As.	asiii	84-89	latexin	Homo sapiens	149-152