PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 25093352-3 2014 The asymmetric unit contains a half-occupancy metal center eta(6)-coordinated to one pyrene ligand, with the full M(pyrene)2 molecule generated by a crystallographic inversion center. pyrene 85-91 endothelin receptor type A Homo sapiens 47-50 25587303-0 2014 Preparation of Pluronic/Bile salt/Phospholipid Mixed Micelles as Drug Solubility Enhancer and Study the Effect of the PPO Block Size on the Solubility of Pyrene. pyrene 154-160 protoporphyrinogen oxidase Homo sapiens 118-121 25587303-6 2014 The results obtained from these experiments suggest that the mixed micelles was more stable and solubilize more pyrene than single one; and the solubilization of pyrene was strong effected by the PPO block size, thus accentuating synergistic interaction mechanism in Pluronic/BS/PS-MM. pyrene 162-168 protoporphyrinogen oxidase Homo sapiens 196-199 25176188-1 2014 For the development of the excimer probe responsible for DNA target, the deoxyuridine phosphoramidite derivative bearing the silylated pyrene attached at the C-5 position was prepared and incorporated into oligonucleotides. pyrene 135-141 complement C5 Homo sapiens 158-161 25119430-1 2014 Microsized chemosensor particle (CPP-16, CPP means coordination polymer particle), which is made from a metal-organic framework (MOF), is synthesized using pyrene-functionalized organic building block. pyrene 156-162 lysine acetyltransferase 8 Homo sapiens 104-133 25119430-5 2014 After MOF construction, pyrene moieties experience an unusual complete conversion from monomer to excimer form. pyrene 24-30 lysine acetyltransferase 8 Homo sapiens 6-9 25060863-1 2014 The effects of the planar aromatic organic molecules anthracene and pyrene on the catalytic performance of the intramolecular hydrogen evolving photocatalyst [Ru(tbbpy)2(tpphz)PdCl2](PF6)2 functioning as a photocatalytic dyad have been studied. pyrene 68-74 sperm associated antigen 17 Homo sapiens 183-186 25060863-5 2014 Studies on the photocatalytic hydrogen production show a decreased induction phase and increased turn over frequencies during the initial phase of the catalysis in the presence of anthracene and pyrene utilising the catalyst [Ru(tbbpy)2(tpphz)PdCl2](PF6)2 irrespective of the nature of the polycyclic aromatic hydrocarbon. pyrene 195-201 sperm associated antigen 17 Homo sapiens 250-253 25228686-2 2014 Here, we have evaluated a potential role of WRN (mutated in Werner syndrome) and RECQ1 (the most abundant homolog of WRN) in hydroquinone (HQ)- and benzo[a]pyrene (BaP)-induced genotoxicity. pyrene 156-162 WRN RecQ like helicase Homo sapiens 44-47 25228686-2 2014 Here, we have evaluated a potential role of WRN (mutated in Werner syndrome) and RECQ1 (the most abundant homolog of WRN) in hydroquinone (HQ)- and benzo[a]pyrene (BaP)-induced genotoxicity. pyrene 156-162 WRN RecQ like helicase Homo sapiens 117-120 25093352-5 2014 As in the other two compounds, the asymmetric unit contains a half-occupancy Ti atom eta(6)-coordinated to one pyrene ligand. pyrene 111-117 endothelin receptor type A Homo sapiens 85-88 24866239-4 2014 Pyrene-labeled recombinant human apoE3 displayed a robust ability to stimulate ABCA1-mediated cholesterol efflux from cholesterol-loaded J774 macrophages (which do not express apoE), comparable to that elicited by unlabeled apoE3. pyrene 0-6 apolipoprotein E Homo sapiens 33-37 24866239-4 2014 Pyrene-labeled recombinant human apoE3 displayed a robust ability to stimulate ABCA1-mediated cholesterol efflux from cholesterol-loaded J774 macrophages (which do not express apoE), comparable to that elicited by unlabeled apoE3. pyrene 0-6 apolipoprotein E Homo sapiens 224-229 24866239-0 2014 A pyrene based fluorescence approach to study conformation of apolipoprotein E3 in macrophage-generated nascent high density lipoprotein. pyrene 2-8 apolipoprotein E Homo sapiens 62-79 24866239-3 2014 The objective of this study is to understand the conformation adopted by apoE3 in macrophage-generated nHDL using a fluorescence spectroscopic approach involving pyrene. pyrene 162-168 apolipoprotein E Homo sapiens 73-78 24866239-8 2014 A significant extent of pyrene excimer emission was noted in nHDL, indicative of spatial proximity between Cys112 on neighboring apoE3 molecules similar to that noted in reconstituted HDL. pyrene 24-30 apolipoprotein E Homo sapiens 129-134 24866239-4 2014 Pyrene-labeled recombinant human apoE3 displayed a robust ability to stimulate ABCA1-mediated cholesterol efflux from cholesterol-loaded J774 macrophages (which do not express apoE), comparable to that elicited by unlabeled apoE3. pyrene 0-6 apolipoprotein E Homo sapiens 33-38 24866239-11 2014 A similar organization of the C-terminal tail of apoE on nHDL was noted when pyrene-apoEA277C(201-299) was used as the cholesterol acceptor. pyrene 77-83 apolipoprotein E Homo sapiens 49-53 24709094-14 2014 With the analyses of data collected over a longer period of time (2001-2012), a decreasing trend was observed in pyrene (APC=-2.76%; p<0.01), mostly driven by measures from the nonheating season (APC=-3.54%; p<0.01). pyrene 113-119 APC regulator of WNT signaling pathway 2 Homo sapiens 121-127 24866239-4 2014 Pyrene-labeled recombinant human apoE3 displayed a robust ability to stimulate ABCA1-mediated cholesterol efflux from cholesterol-loaded J774 macrophages (which do not express apoE), comparable to that elicited by unlabeled apoE3. pyrene 0-6 ATP binding cassette subfamily A member 1 Homo sapiens 79-84 24356981-0 2014 Community structure and PAH ring-hydroxylating dioxygenase genes of a marine pyrene-degrading microbial consortium. pyrene 77-83 phenylalanine hydroxylase Homo sapiens 24-27 24356981-1 2014 Marine microbial consortium UBF, enriched from a beach polluted by the Prestige oil spill and highly efficient in degrading this heavy fuel, was subcultured in pyrene minimal medium. pyrene 160-166 upstream binding transcription factor Homo sapiens 28-31 24356981-2 2014 The pyrene-degrading subpopulation (UBF-Py) mineralized 31 % of pyrene without accumulation of partially oxidized intermediates indicating the cooperation of different microbial components in substrate mineralization. pyrene 4-10 upstream binding transcription factor Homo sapiens 36-39 24356981-2 2014 The pyrene-degrading subpopulation (UBF-Py) mineralized 31 % of pyrene without accumulation of partially oxidized intermediates indicating the cooperation of different microbial components in substrate mineralization. pyrene 64-70 upstream binding transcription factor Homo sapiens 36-39 24356981-8 2014 However, sequences related to the NidA3 pyrene dioxygenase present in mycobacterial strains were detected in UBF-Py consortium, suggesting the representative of Gordonia as the key pyrene degrader, which is consistent with a preeminent role of actinobacteria in pyrene removal in coastal environments affected by marine oil spills. pyrene 40-46 upstream binding transcription factor Homo sapiens 109-112 24356981-8 2014 However, sequences related to the NidA3 pyrene dioxygenase present in mycobacterial strains were detected in UBF-Py consortium, suggesting the representative of Gordonia as the key pyrene degrader, which is consistent with a preeminent role of actinobacteria in pyrene removal in coastal environments affected by marine oil spills. pyrene 181-187 upstream binding transcription factor Homo sapiens 109-112 24709094-14 2014 With the analyses of data collected over a longer period of time (2001-2012), a decreasing trend was observed in pyrene (APC=-2.76%; p<0.01), mostly driven by measures from the nonheating season (APC=-3.54%; p<0.01). pyrene 113-119 cell division cycle 27 Homo sapiens 199-205 24709094-15 2014 In contrast, levels of pyrene and naphthalene metabolites, 1-hydroxypyrene and 2-naphthol, increased from 2001 to 2012 (APC=6.29% and 7.90% for 1-hydroxypyrene and 2-naphthol, respectively; p<0.01 for both). pyrene 23-29 cell division cycle 16 Homo sapiens 120-125 24644094-1 2014 Coordination of a [Co(hfac)2] moiety (hfac = hexafluoroacetylacetonate) with a nitronylnitroxide radical linked to bulky, rigid pyrene (PyrNN) gives a helical 1:1 chain complex, in which both oxygen atoms of the radical NO( ) groups are bonded to Co(II) ions with strong antiferromagnetic exchange. pyrene 128-134 mitochondrially encoded cytochrome c oxidase II Homo sapiens 247-253 24596056-2 2014 Pyrene-substituted PDI were the most efficient singlet oxygen generator among the investigated photosensitizers with a quantum yield of Phi Delta = 0.93 in toluene/methanol. pyrene 0-6 peptidyl arginine deiminase 1 Homo sapiens 19-22 24328262-3 2014 The PRX core-shell particles are able to sequester small organic molecules, such as pyrene and calcein, releasing these small molecules during degradation. pyrene 84-90 periaxin Homo sapiens 4-7 24397619-0 2014 Confocal Raman microscopy for in situ detection of solid-phase extraction of pyrene into single C18-silica particles. pyrene 77-83 Bardet-Biedl syndrome 9 Homo sapiens 96-99 24397619-6 2014 By comparing the Raman scattering intensity of the pyrene with that of the C18 chains in the stationary phase, it was possible to quantify the equilibrium coverage of pyrene relative to the C18 chains. pyrene 167-173 Bardet-Biedl syndrome 9 Homo sapiens 75-78 32261163-2 2013 The hydrophobic molecule binding properties of albumin have been exploited for solubilization of a water-insoluble molecule, pyrene (model drug), by preparation of non-covalent conjugates with bovine serum albumin (BSA). pyrene 125-131 albumin Homo sapiens 47-54 25114913-4 2014 The notable deregulated proteins for PAHs exposure were displayed as follows: lamin-A/C isoform 3 and annexin A1 for benzopyrene; lamin-A/C isoform 3 and DNA topoisomerase 2-alpha for pentacene; poly[ADP-ribose] polymerase 1 (PARP-1) for fluoranthene; and talin-1 and DNA topoisomerase 2-alpha for pyrene. pyrene 122-128 annexin A1a Danio rerio 102-112 23842862-1 2014 A microcosm experiment was conducted to investigate the dissipation of available benzo[a]pyrene (BaP) in soils co-contaminated with cadmium (Cd) and pyrene (PYR) during aging process. pyrene 89-95 prohibitin 2 Homo sapiens 97-100 23842862-8 2014 The addition of PYR (250 mg kg(-1)) remarkably promoted the dissipation of available BaP without reducing Cd availability in the soil. pyrene 16-19 prohibitin 2 Homo sapiens 85-88 25095992-0 2014 Use of pyrene-labelled actin to probe actin-myosin interactions: kinetic and equilibrium studies. pyrene 7-13 myosin heavy chain 14 Homo sapiens 44-50 25095992-2 2014 The fluorescent label pyrene, covalently attached to actin (at Cys 374), has been one of the most useful optical probes to report myosin binding to actin. pyrene 22-28 myosin heavy chain 14 Homo sapiens 130-136 25638374-1 2014 OBJECTIVES: Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH). pyrene 178-184 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-37 25638374-1 2014 OBJECTIVES: Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH). pyrene 178-184 epoxide hydrolase 1 Homo sapiens 212-240 25638374-1 2014 OBJECTIVES: Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH). pyrene 178-184 epoxide hydrolase 1, microsomal Mus musculus 242-245 24367071-3 2014 The kinetics of interaction of IkappaBalpha with NF-kappaB and its complex with DNA were analyzed by using stopped-flow experiments in which fluorescence changes in pyrene-labeled DNA or the native tryptophan in IkappaBalpha were monitored. pyrene 165-171 NFKB inhibitor alpha Homo sapiens 31-43 24316887-4 2014 Compared to the analogues of TNT, the PVP/pyrene/APTS/rGO nanonets showed notable selectivity towards TNT and DNT vapors. pyrene 42-48 5', 3'-nucleotidase, cytosolic Homo sapiens 110-113 24209350-0 2013 A highly sensitive and selective turn-on fluorogenic and colorimetric sensor based on pyrene-functionalized magnetic nanoparticles for Hg2+ detection and cell imaging. pyrene 86-92 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 135-138 32261163-2 2013 The hydrophobic molecule binding properties of albumin have been exploited for solubilization of a water-insoluble molecule, pyrene (model drug), by preparation of non-covalent conjugates with bovine serum albumin (BSA). pyrene 125-131 albumin Homo sapiens 200-213 23782930-8 2013 CONCLUSION: This study reveals the high pyrene (PAH) exposure of the Kinshasa population. pyrene 40-46 phenylalanine hydroxylase Homo sapiens 48-51 23912830-0 2013 Detection of thrombin using an excimer aptamer switch labeled with dual pyrene molecules. pyrene 72-78 coagulation factor II, thrombin Homo sapiens 13-21 23912830-1 2013 We constructed an excimer aptamer probe containing one pyrene molecule at each end of a DNA aptamer to achieve the detection of thrombin, which binds to the heparin-binding site of thrombin with high binding affinity. pyrene 55-61 coagulation factor II, thrombin Homo sapiens 128-136 23912830-1 2013 We constructed an excimer aptamer probe containing one pyrene molecule at each end of a DNA aptamer to achieve the detection of thrombin, which binds to the heparin-binding site of thrombin with high binding affinity. pyrene 55-61 coagulation factor II, thrombin Homo sapiens 181-189 23912830-2 2013 The specific binding of thrombin to the excimer aptamer probe brought the two pyrene molecules at the termini of the duplex of the aptamer into close proximity, generating an excimer. pyrene 78-84 coagulation factor II, thrombin Homo sapiens 24-32 23718926-5 2013 The observation under the dilute condition (~0.1 muM) indicates that the emission spectral change was caused by the motion of a protein molecule and not led by protein-protein interactions through pi-pi stacking of pyrene rings. pyrene 215-221 latexin Homo sapiens 49-52 23519528-0 2013 Spectroscopic characterization of i-motif forming c-myc derived sequences double-labeled with pyrene. pyrene 94-100 MYC proto-oncogene, bHLH transcription factor Homo sapiens 50-55 23519528-1 2013 In current studies we use the oligonucleotides based on c-myc sequence: CCC CAC CCT CCC CAC CCT CCC C (cmyc22) and CCC CAC CCT CCC CAC CCT CCC CA (cmyc22A) functionalized by pyrene moieties at both termini. pyrene 174-180 MYC proto-oncogene, bHLH transcription factor Homo sapiens 56-61 23972896-9 2013 Urinary 1-hydroxypyrene, the biomarker of the higher molecular weight pyrene, was positively associated with total WBC count, and to lesser extent with serum CRP. pyrene 17-23 C-reactive protein Homo sapiens 158-161 23782930-9 2013 However, more work, with a rigorous design in the exposed population (monitoring of air concentrations and identifying other sources of pyrene -PAH exposure), is needed to establish further documentation. pyrene 136-142 phenylalanine hydroxylase Homo sapiens 144-147 23486775-2 2013 GOx was first modified with pyrene functionalities in order to be self-assembled onto a graphene basal plane via non-covalent pi-pi stacking interaction. pyrene 28-34 hydroxyacid oxidase 1 Homo sapiens 0-3 26283241-2 2013 We produced 1-C16H11(+) and 1-C16H11 upon electron bombardment during matrix deposition of p-H2 containing pyrene (C16H10) in a small proportion. pyrene 107-113 polyhomeotic homolog 2 Homo sapiens 91-95 26283241-2 2013 We produced 1-C16H11(+) and 1-C16H11 upon electron bombardment during matrix deposition of p-H2 containing pyrene (C16H10) in a small proportion. pyrene 115-121 polyhomeotic homolog 2 Homo sapiens 91-95 23611760-6 2013 The presence of NaCl induced a red shift in the emission peaks of DCBS and a decrease of the pyrene polarity index I1/I3 in the gels, which indicated that there was more pi-pi stacking in the hydrogels with NaCl than in the gels without NaCl. pyrene 93-99 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 115-120 23581750-4 2013 In contrast, for a commonly used polarity probe pyrene, the ratio of I3/I1 varies only from ~0.6 to ~1.7, where I3 and I1 stand for the intensities of the fluorescence emission at peak 3 and peak 1, respectively. pyrene 48-54 pseudopodium enriched atypical kinase 1 Homo sapiens 191-197 23434805-3 2013 During pyrene degradation, catechol 1,2 dioxygenase (C12O) activity was induced by 13 folds in BP10 and 17 folds in P2 as compared to catechol 2,3 dioxygenase (C23O). pyrene 7-13 BP10 Homo sapiens 95-99 23434805-5 2013 This clearly indicated that C12O played a major role in pyrene degradation by BP10 and P2, while in NJ2, C23O contributed more to degradation process than C12O. pyrene 56-62 BP10 Homo sapiens 78-82 23467367-5 2013 By pyrene actin assembly assay, dynamin 1 stimulated actin assembly in mouse brain cytosol. pyrene 3-9 dynamin 1 Mus musculus 32-41 23590426-0 2013 Real-time fluorometric assay for acetylcholinesterase activity and inhibitor screening through the pyrene probe monomer-excimer transition. pyrene 99-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 23386421-1 2013 Hole-some mixture: A 2D mesoporous covalent organic framework (see figure) featuring expanded pyrene cores and linked by imine linkages has a high surface area (SA(BET) = 2723 m(2) g(-1)) and exhibits significant gas storage capacities under high pressure, which make this class of material very promising for gas storage applications. pyrene 94-100 delta/notch like EGF repeat containing Homo sapiens 164-167 23486775-3 2013 Fluorescence spectroscopy analysis revealed that about 5.4 pyrene functional groups were attached to each GOx and the pyrene functionalized GOx retained more than 76% of the biocatalytical activity compared with the native enzyme. pyrene 59-65 hydroxyacid oxidase 1 Homo sapiens 106-109 23486775-3 2013 Fluorescence spectroscopy analysis revealed that about 5.4 pyrene functional groups were attached to each GOx and the pyrene functionalized GOx retained more than 76% of the biocatalytical activity compared with the native enzyme. pyrene 59-65 hydroxyacid oxidase 1 Homo sapiens 140-143 23486775-3 2013 Fluorescence spectroscopy analysis revealed that about 5.4 pyrene functional groups were attached to each GOx and the pyrene functionalized GOx retained more than 76% of the biocatalytical activity compared with the native enzyme. pyrene 118-124 hydroxyacid oxidase 1 Homo sapiens 106-109 23486775-3 2013 Fluorescence spectroscopy analysis revealed that about 5.4 pyrene functional groups were attached to each GOx and the pyrene functionalized GOx retained more than 76% of the biocatalytical activity compared with the native enzyme. pyrene 118-124 hydroxyacid oxidase 1 Homo sapiens 140-143 23486775-4 2013 Via alternate layer-by-layer self-assembly of graphene and pyrene functionalized GOx, mono- and multi-layered enzyme electrodes with controlled biocatalytical activity can be easily fabricated. pyrene 59-65 hydroxyacid oxidase 1 Homo sapiens 81-84 23373477-5 2013 Only a minimal number of pyrene units intercalate at one end, favoring formation of very extended longitudinal chains, as also detected by AFM experiment. pyrene 25-31 afamin Homo sapiens 139-142 23837345-2 2013 Pyrene was continuously the most abundant PAH, whereas anthracene was the PAH with the lowest concentrations. pyrene 0-6 phenylalanine hydroxylase Homo sapiens 42-45 23181170-5 2012 Specific binding of PP to oligomeric forms of Abeta can be monitored in solution by a change in fluorescence spectrum as well as a change in pyrene monomer fluorescence anisotropy (or polarization). pyrene 141-147 amyloid beta precursor protein Homo sapiens 46-51 23745427-6 2013 Fluoranthene and pyrene were dominant in PAHs of PM emissions when the diesel car used pure diesel or B10 fuel. pyrene 17-23 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 102-105 23192191-2 2012 In this work, the interactions of two selected pyrene derivatives (1-OHP and 1-PBO) and human tumor-related DNA (p53 DNA and C-myc DNA) are investigated by spectroscopic and non-native polyacrylamide gel electrophoresis (PAGE) methods. pyrene 47-53 tumor protein p53 Homo sapiens 113-116 23052197-3 2013 Recently, the differential gene expression response in wild-type and cancer-prone Xpa (-/-) p53 (+/-) primary mouse hepatocytes after exposure to benzo[a]pyrene (B[a]P) revealed downregulation of cancer-related pathways in Xpa (-/-) p53 (+/-) hepatocytes only. pyrene 202-208 xeroderma pigmentosum, complementation group A Mus musculus 82-85 23052197-3 2013 Recently, the differential gene expression response in wild-type and cancer-prone Xpa (-/-) p53 (+/-) primary mouse hepatocytes after exposure to benzo[a]pyrene (B[a]P) revealed downregulation of cancer-related pathways in Xpa (-/-) p53 (+/-) hepatocytes only. pyrene 202-208 transformation related protein 53, pseudogene Mus musculus 124-127 23052197-3 2013 Recently, the differential gene expression response in wild-type and cancer-prone Xpa (-/-) p53 (+/-) primary mouse hepatocytes after exposure to benzo[a]pyrene (B[a]P) revealed downregulation of cancer-related pathways in Xpa (-/-) p53 (+/-) hepatocytes only. pyrene 202-208 xeroderma pigmentosum, complementation group A Mus musculus 271-274 23052197-3 2013 Recently, the differential gene expression response in wild-type and cancer-prone Xpa (-/-) p53 (+/-) primary mouse hepatocytes after exposure to benzo[a]pyrene (B[a]P) revealed downregulation of cancer-related pathways in Xpa (-/-) p53 (+/-) hepatocytes only. pyrene 202-208 transformation related protein 53, pseudogene Mus musculus 313-316 23089391-1 2013 The photochemistry of pyrene, a polycyclic aromatic hydrocarbon, adsorbed on kaolinite, sodium montmorillonite and acid bentonite K10 was investigated to determine how the concentration and structure of the clay minerals affect the formation of different species of pyrene. pyrene 22-28 keratin 10 Homo sapiens 130-133 23590136-6 2013 In addition, several research groups including our laboratory have reported that MT-I/II null mice are highly susceptible to several carcinogenesis caused by 7,12-dimethylbenz[a]anthracene, X-ray, benzo[a]pyrene, N-butyl-N-(4-hydroxybutyl) nitrosamine, lead, and cisplatin. pyrene 205-211 metallothionein 3 Mus musculus 81-88 23192191-2 2012 In this work, the interactions of two selected pyrene derivatives (1-OHP and 1-PBO) and human tumor-related DNA (p53 DNA and C-myc DNA) are investigated by spectroscopic and non-native polyacrylamide gel electrophoresis (PAGE) methods. pyrene 47-53 MYC proto-oncogene, bHLH transcription factor Homo sapiens 125-130 23192191-6 2012 Besides, the binding of pyrene derivatives to p53 DNA is stronger than that for C-myc DNA. pyrene 24-30 tumor protein p53 Homo sapiens 46-49 23192191-6 2012 Besides, the binding of pyrene derivatives to p53 DNA is stronger than that for C-myc DNA. pyrene 24-30 MYC proto-oncogene, bHLH transcription factor Homo sapiens 80-85 22887912-1 2012 Small-angle neutron scattering (SANS) and diffusion NMR studies are performed to investigate the stability and geometry of hydrogen-bonded pyrene-guest-containing C-hexylpyrogallol[4]arene (PgC(6) -pyrene) nanotubular frameworks in solution. pyrene 139-145 progastricsin Homo sapiens 190-193 23116258-1 2012 Because of the lack of sensitivity to small changes in distance by available FRET pairs (a constraint imposed by the dimensions of the enzyme), a DHFR containing two pyrene moieties was prepared to enable the observation of excimer formation. pyrene 166-172 dihydrofolate reductase Homo sapiens 146-150 23199925-6 2012 Here, we investigated the solution conformation of the dystrophin N-ABD using a very simple and elegant technique of pyrene excimer fluorescence. pyrene 117-123 dystrophin Homo sapiens 55-65 22887912-2 2012 In the solid state, hydrogen-bonded pyrogallol[4]arene tubes are formed; however, the scattering data for PgC(6) -pyrene assemblies in acetone are best modeled as dimeric spheres of PgC(6) with no pyrene guest. pyrene 114-120 progastricsin Homo sapiens 106-109 22869394-3 2012 The following PAH were found in bioavailable form: acenaphthylene, acenaphthene, fluorene, phenanthrene, anthracene, fluoranthene, pyrene, with C(free) varying between 2.38 and 62.35 ng/L. pyrene 131-137 phenylalanine hydroxylase Homo sapiens 14-17 22791346-3 2012 The ability of this consortium to utilise HMW PAHs such as pyrene and BaP as a sole carbon source in the presence of toxic metal Cd was demonstrated. pyrene 59-65 cilia and flagella associated protein 97 Homo sapiens 42-45 22973053-6 2012 In vitro pyrene-actin polymerization assays established that Sla1 inhibition of Las17 activity depends on the class I/II Las17 polyproline motifs and is based on competition between Sla1 and monomeric actin for binding to Las17. pyrene 9-15 cytoskeletal protein-binding protein SLA1 Saccharomyces cerevisiae S288C 61-65 22973053-6 2012 In vitro pyrene-actin polymerization assays established that Sla1 inhibition of Las17 activity depends on the class I/II Las17 polyproline motifs and is based on competition between Sla1 and monomeric actin for binding to Las17. pyrene 9-15 actin-binding protein LAS17 Saccharomyces cerevisiae S288C 80-85 22772988-5 2012 MD simulations show that the near error-free incorporation of dCTP opposite the major benzo[a]pyrene-derived dG lesion is compatible with the WMSA mechanism, allowing for an essentially undisturbed pentacovalent phosphorane transition state, and explaining the bypass of this lesion with little mutation by Pol kappa. pyrene 94-100 DNA polymerase lambda Homo sapiens 307-316 22551628-0 2012 Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) alpha/delta dual agonist. pyrene 41-47 peroxisome proliferator activated receptor alpha Homo sapiens 54-109 22917263-3 2012 A large aromatic expanse extant to the pyrene core in TP2 permits inclusion of two different types of guest species interchangeably. pyrene 39-45 transition protein 2 Homo sapiens 54-57 22626472-4 2012 The PAH metabolites of naphthalene, fluorene, phenanthrene, and pyrene each showed both positive and negative correlations with homocysteine, fibrinogen, and white blood cell count (correlation coefficient range: -0.077-0.143) in nonsmoking participants. pyrene 64-70 fibrinogen beta chain Homo sapiens 142-152 22667354-6 2012 Using a combination of SDS-PAGE, size exclusion chromatography, and pyrene excimer fluorescence, we show that in the absence of the coiled-coil domain the transmembrane domain of human tetherin forms parallel homodimers in membrane mimetic environments. pyrene 68-74 bone marrow stromal cell antigen 2 Homo sapiens 185-193 22446788-1 2012 The phenomenon of Forster resonance energy transfer (FRET) between pyrene and bovine serum albumin (BSA) protein in presence of cyclodextrins (CDs) is explored in the present work. pyrene 67-73 albumin Homo sapiens 85-104 22446788-3 2012 In this work we revealed that along with pyrene monomer, the side chains of amino acids in BSA can get trapped partly in the hydrophobic cavities of CDs if space permits. pyrene 41-47 albumin Homo sapiens 91-94 22446788-4 2012 While being encapsulated by beta-CD as pyrene monomer, it can interact with the BSA tryptophan moiety exposed toward the aqueous environment to form a dimer through pi-pi interaction. pyrene 39-45 albumin Homo sapiens 80-83 22779734-0 2012 The extent of pyrene excimer fluorescence emission is a reflector of distance and flexibility: analysis of the segment linking the LDL receptor-binding and tetramerization domains of apolipoprotein E3. pyrene 14-20 apolipoprotein E Homo sapiens 183-200 22779734-9 2012 This study offers new insights into the conformation of tetrameric apoE and presents the use of pyrene as a powerful probe for studying protein spatial organization. pyrene 96-102 apolipoprotein E Homo sapiens 67-71 22730894-4 2012 Pyrene excimer fluorescence together with gel filtration chromatography indicated that there are extensive intermolecular helix-helix contacts through the C-terminal helices of apoE4. pyrene 0-6 apolipoprotein E Homo sapiens 177-182 22730894-5 2012 Comparison of increases in pyrene fluorescence upon binding of pyrene-labeled apoE4 to egg phosphatidylcholine small unilamellar vesicles suggests a two-step lipid-binding process; apoE4 initially binds to a lipid surface through the C-terminal helices followed by the slower conformational reorganization of the N-terminal helix bundle domain. pyrene 27-33 apolipoprotein E Homo sapiens 78-83 22730894-5 2012 Comparison of increases in pyrene fluorescence upon binding of pyrene-labeled apoE4 to egg phosphatidylcholine small unilamellar vesicles suggests a two-step lipid-binding process; apoE4 initially binds to a lipid surface through the C-terminal helices followed by the slower conformational reorganization of the N-terminal helix bundle domain. pyrene 27-33 apolipoprotein E Homo sapiens 181-186 22730894-5 2012 Comparison of increases in pyrene fluorescence upon binding of pyrene-labeled apoE4 to egg phosphatidylcholine small unilamellar vesicles suggests a two-step lipid-binding process; apoE4 initially binds to a lipid surface through the C-terminal helices followed by the slower conformational reorganization of the N-terminal helix bundle domain. pyrene 63-69 apolipoprotein E Homo sapiens 78-83 22730894-5 2012 Comparison of increases in pyrene fluorescence upon binding of pyrene-labeled apoE4 to egg phosphatidylcholine small unilamellar vesicles suggests a two-step lipid-binding process; apoE4 initially binds to a lipid surface through the C-terminal helices followed by the slower conformational reorganization of the N-terminal helix bundle domain. pyrene 63-69 apolipoprotein E Homo sapiens 181-186 22730894-8 2012 However, monitoring pyrene fluorescence upon binding to HDL(3) suggests that not only apoE-lipid interactions but also protein-protein interactions are important for apoE4 binding to HDL(3). pyrene 20-26 apolipoprotein E Homo sapiens 166-171 22446823-3 2012 Herein, we address the cardiac developmental effects of exposure to the weak AhR agonist pyrene on the early life-stages of zebrafish. pyrene 89-95 aryl hydrocarbon receptor 1a Danio rerio 77-80 22446823-8 2012 However, the homeodomain transcription factor Nkx2.5, which plays an essential role in the development of the cardiovascular system, was down-regulated in a dose-dependent manner by pyrene exposure. pyrene 182-188 NK2 homeobox 5 Danio rerio 46-52 22446823-9 2012 The bone morphogenetic protein 2b (Bmp2b), which has been identified as the upstream gene of Nkx2.5, also was inhibited in a dose-dependent manner after treatment with pyrene. pyrene 168-174 bone morphogenetic protein 2b Danio rerio 4-33 22446823-9 2012 The bone morphogenetic protein 2b (Bmp2b), which has been identified as the upstream gene of Nkx2.5, also was inhibited in a dose-dependent manner after treatment with pyrene. pyrene 168-174 bone morphogenetic protein 2b Danio rerio 35-40 22446823-9 2012 The bone morphogenetic protein 2b (Bmp2b), which has been identified as the upstream gene of Nkx2.5, also was inhibited in a dose-dependent manner after treatment with pyrene. pyrene 168-174 NK2 homeobox 5 Danio rerio 93-99 22551628-1 2012 Based on X-ray crystallographic analysis of a peroxisome proliferator-activated receptor (PPAR) alpha/delta dual agonist complexed with human PPARs ligand binding domain (LBD), we previously reported the design and synthesis of a pyrene-based fluorescent PPARalpha/delta co-agonist 2. pyrene 230-236 peroxisome proliferator activated receptor alpha Homo sapiens 46-101 22551628-1 2012 Based on X-ray crystallographic analysis of a peroxisome proliferator-activated receptor (PPAR) alpha/delta dual agonist complexed with human PPARs ligand binding domain (LBD), we previously reported the design and synthesis of a pyrene-based fluorescent PPARalpha/delta co-agonist 2. pyrene 230-236 peroxisome proliferator activated receptor alpha Homo sapiens 255-264 22551628-4 2012 Site-directed mutagenesis of the two hPPAR subtypes clearly indicated that Trp264 of hPPARdelta-LBD, located between H2" helix and H3 helix (omega loop), is critical for the concentration-dependent decrease in fluorescence intensity, which is suggested to be due to fluorescence resonance energy transfer (FRET) from the pyrene moiety of bound 2 to the nearby side-chain indole moiety of Trp264 in the hPPARdelta-LBD. pyrene 321-327 peroxisome proliferator activated receptor alpha Homo sapiens 37-42 22253057-0 2012 Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) mice. pyrene 71-77 glutamate-cysteine ligase, modifier subunit Mus musculus 148-152 22147501-5 2012 The proteoliposomes containing BI-1 increased the quenching of DXR fluorescence by Cu(2+), and the fluorescence energy transfer between pyrene-labeled BI-1 and DXR was enhanced with increasing DXR concentrations. pyrene 136-142 transmembrane BAX inhibitor motif containing 6 Homo sapiens 31-35 22147501-5 2012 The proteoliposomes containing BI-1 increased the quenching of DXR fluorescence by Cu(2+), and the fluorescence energy transfer between pyrene-labeled BI-1 and DXR was enhanced with increasing DXR concentrations. pyrene 136-142 transmembrane BAX inhibitor motif containing 6 Homo sapiens 151-155 22228805-0 2012 Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice. pyrene 21-27 aryl-hydrocarbon receptor Mus musculus 49-74 22119279-7 2012 Compared with control the highest increments of GPOD, CAT, APX, GR and MDA by PHE/PYR alone treatments were observed following 300muM concentration, which were 67%, 87%, 53%, 95% and 74% by PHE and 42%, 53%, 30%, 86% and 62% by PYR, respectively. pyrene 82-85 catalase isozyme 1 Solanum lycopersicum 54-57 22143433-2 2012 Two potentially tetradentate ligands containing one (L(1)) and two (L(2)) terminal pyrene moieties were synthesised and their complexes with Cu(+) and Cd(2+) were characterised. pyrene 83-89 immunoglobulin kappa variable 3-15 Homo sapiens 68-72 22143433-3 2012 Photophysical measurements demonstrate that in [Cu(2)(L(1))(2)](2+), [CdL(1)](2+) and [Cu(2)(L(2))(2)](2+) the emission spectra are dominated by monomeric emission but in the cadmium complex of L(2) (where the pyrene units are in close proximity) a quenching of the luminescence coupled with weak emission at 540 nm is indicative of excimer formation. pyrene 210-216 immunoglobulin kappa variable 3-15 Homo sapiens 93-97 22143433-3 2012 Photophysical measurements demonstrate that in [Cu(2)(L(1))(2)](2+), [CdL(1)](2+) and [Cu(2)(L(2))(2)](2+) the emission spectra are dominated by monomeric emission but in the cadmium complex of L(2) (where the pyrene units are in close proximity) a quenching of the luminescence coupled with weak emission at 540 nm is indicative of excimer formation. pyrene 210-216 immunoglobulin kappa variable 3-15 Homo sapiens 194-198 22119279-7 2012 Compared with control the highest increments of GPOD, CAT, APX, GR and MDA by PHE/PYR alone treatments were observed following 300muM concentration, which were 67%, 87%, 53%, 95% and 74% by PHE and 42%, 53%, 30%, 86% and 62% by PYR, respectively. pyrene 82-85 cytosolic ascorbate peroxidase 2 Solanum lycopersicum 59-62 22119279-7 2012 Compared with control the highest increments of GPOD, CAT, APX, GR and MDA by PHE/PYR alone treatments were observed following 300muM concentration, which were 67%, 87%, 53%, 95% and 74% by PHE and 42%, 53%, 30%, 86% and 62% by PYR, respectively. pyrene 82-85 glutathione reductase Solanum lycopersicum 64-66 21839799-0 2011 Effects of subchronic benzo(a)pyrene exposure on neurotransmitter receptor gene expression in the rat hippocampus related with spatial learning and memory change. pyrene 30-36 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 49-74 22077105-4 2012 The naphthalene, pyrene, and coronene derivatives do not react under Scholl conditions but are fused using thermal cyclodehydrogenation at high temperatures, giving mixtures of syn and anti isomers of the meso,beta-fused porphyrins. pyrene 17-23 synemin Homo sapiens 177-180 22028397-4 2012 Using bisulfite sequencing, we examined the methylation status of p16(INK4alpha) promoter in peripheral blood lymphocytes (PBL) from PAH-exposed workers and in benzo(a)pyrene (BaP)-transformed human bronchial epithelial (HBE) cells. pyrene 168-174 cyclin dependent kinase inhibitor 2A Homo sapiens 70-79 21683090-0 2011 Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative. pyrene 107-113 MYC proto-oncogene, bHLH transcription factor Homo sapiens 87-92 21911080-0 2011 Benzo(a)pyrene-induced mitochondrial dysfunction and cell death in p53-null Hep3B cells. pyrene 8-14 tumor protein p53 Homo sapiens 67-70 22048643-0 2012 Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation. pyrene 54-60 microRNA 638 Homo sapiens 23-30 22613966-0 2012 NHE-1 relocation outside cholesterol-rich membrane microdomains is associated with its benzo[a]pyrene-related apoptotic function. pyrene 95-101 solute carrier family 9 member A1 Homo sapiens 0-5 22225155-3 2011 Similar to pyrene, another peri-condensed polycyclic aromatic hydrocarbon we have investigated, the first two electronically excited states of BaP exhibit extensive configuration interactions. pyrene 11-17 prohibitin 2 Homo sapiens 143-146 21882808-1 2011 A water-soluble pyrene-based butterfly shaped conjugated oligoelectrolyte (TFP) is synthesized and integrated with graphene oxide (GO) to form a label-free assay for heparin detection. pyrene 16-22 inhibitor of carbonic anhydrase pseudogene Homo sapiens 75-78 21350744-1 2011 Pyrene excimer fluorescence is efficiently regulated through formation of pi-stacked aggregates between dialkynylpyrene (Y) and perylenediimide (E) residues located in the stem region of a molecular beacon (MB). pyrene 0-6 ubiquitin like 5 Homo sapiens 199-205 21735014-2 2011 The pyrene units are syn in orientation; this is supported by a strong excimer signal observed at 410 nm in the presence of ZnCl(2) in acetonitrile. pyrene 4-10 synemin Homo sapiens 21-24 21445860-2 2011 CHO cells transformed with the rat 4S PAH receptor/GNMT expression vector had twice the induction level of luciferase activity with respect to wild-type CHO cells in concert with previously published reports that the 4S PAH receptor/GNMT mediates benzo[a]pyrene induction of CYP1A1 gene expression. pyrene 255-261 glycine N-methyltransferase Rattus norvegicus 51-55 21445860-2 2011 CHO cells transformed with the rat 4S PAH receptor/GNMT expression vector had twice the induction level of luciferase activity with respect to wild-type CHO cells in concert with previously published reports that the 4S PAH receptor/GNMT mediates benzo[a]pyrene induction of CYP1A1 gene expression. pyrene 255-261 glycine N-methyltransferase Cricetulus griseus 233-237 21623316-1 2011 FeCl3-mediated oxidative cyclization was successfully used to construct an extended thiophene-pendant pyrene skeleton and synthesize a novel thiophene-fused polycyclic aromatic (THTP-C) with a tetracene core. pyrene 102-108 thiamine triphosphatase Homo sapiens 178-182 21305582-5 2011 As an indicator of polarity around the pyrene molecule, the ratio of intensity of pyrene at 374 nm and 384 nm (I1/I3) decreased with the increase of fulvic acid fraction concentrations. pyrene 39-45 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 111-116 21305582-5 2011 As an indicator of polarity around the pyrene molecule, the ratio of intensity of pyrene at 374 nm and 384 nm (I1/I3) decreased with the increase of fulvic acid fraction concentrations. pyrene 82-88 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 111-116 21275995-4 2011 The biochemical property of AtVLN4 was characterized by co-sedimentation assays, fluorescence microscopy and spectroscopy of pyrene fluorescence. pyrene 125-131 villin 4 Arabidopsis thaliana 28-34 21528977-2 2011 Using density functional theory (DFT) at the GGA-PBE level, the chemical binding of atomic hydrogen to pyrene is found to be exothermic by up to 1.6 eV with a strong site dependence. pyrene 103-109 enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Homo sapiens 49-52 21786685-1 2011 Effect of carcinogenic polycyclic aromatic hydrocarbons (PAH) benzo(a)pyrene (BP) and 3-methylcholanthrene (MC) on transcription factor NF-kappaB activation was studied. pyrene 70-76 nuclear factor kappa B subunit 1 Homo sapiens 136-145 22007301-6 2011 Pyrene attached to Hsp27 exhibited a large excimer fluorescence, in agreement with the known proximity of the cysteine-137"s in the Hsp27 oligomer. pyrene 0-6 heat shock protein family B (small) member 1 Homo sapiens 19-24 22007301-6 2011 Pyrene attached to Hsp27 exhibited a large excimer fluorescence, in agreement with the known proximity of the cysteine-137"s in the Hsp27 oligomer. pyrene 0-6 heat shock protein family B (small) member 1 Homo sapiens 132-137 21341800-4 2011 (I(E)/I(M))(SPC), the ratio of pyrene monomer to excimer fluorescence intensities, was calculated from parameters retrieved from the MF analysis of the fluorescence decays and was found to be independent of sample geometry. pyrene 31-37 proline rich protein gene cluster Homo sapiens 12-15 20464547-0 2010 Potential roles of fibroblast growth factor-9 in the benzo(a)pyrene-induced invasion in vitro and the metastasis of human lung adenocarcinoma. pyrene 61-67 fibroblast growth factor 9 Homo sapiens 19-45 20883688-2 2010 The purpose of this study is to evaluate the effect of hesperidin in modulating the expressions of cyclooxygenase-2 (COX-2), mast cells (MCs) and matrix metalloproteinases (MMPs) during benzo(a)pyrene (B(a)P) induced lung carcinogenesis in mice. pyrene 194-200 prostaglandin-endoperoxide synthase 2 Mus musculus 99-115 21143968-4 2010 The goal of the present study was to determine whether hRev7 is similarly involved in the tolerance of DNA damage induced by benzo[a]pyrene diol epoxide (BPDE), the reactive form of the widespread environmental carcinogen benzo[a]pyrene. pyrene 133-139 mitotic arrest deficient 2 like 2 Homo sapiens 55-60 20637319-10 2010 Molecular association between RFX5DBD and RFXANK has been observed by fluorescence resonance energy transfer (FRET) measurements, changes in the ratio of the two vibronic intensities of pyrene labeled RFX5DBD in presence of RFXANK and chemical cross-linking followed by tandem mass spectrometry. pyrene 186-192 regulatory factor X associated ankyrin containing protein Homo sapiens 42-48 20637319-10 2010 Molecular association between RFX5DBD and RFXANK has been observed by fluorescence resonance energy transfer (FRET) measurements, changes in the ratio of the two vibronic intensities of pyrene labeled RFX5DBD in presence of RFXANK and chemical cross-linking followed by tandem mass spectrometry. pyrene 186-192 regulatory factor X5 Homo sapiens 30-34 20511593-0 2010 Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage. pyrene 127-133 three prime repair exonuclease 1 Homo sapiens 27-32 20511593-0 2010 Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage. pyrene 127-133 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 37-40 20511593-0 2010 Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage. pyrene 127-133 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 41-45 20674550-4 2010 In a genome-wide P450 microarray screen, we identified six PAH-responsive P450 genes (Pc-pah1-Pc-pah6) inducible by PAHs of varying ring size, namely naphthalene, phenanthrene, pyrene, and benzo(a)pyrene (BaP). pyrene 177-183 prohibitin 2 Homo sapiens 205-208 21080638-0 2010 Competition-mediated pyrene-switching aptasensor: probing lysozyme in human serum with a monomer-excimer fluorescence switch. pyrene 21-27 lysozyme Homo sapiens 58-66 21080638-3 2010 To address these limitations, we report here the design, synthesis, and application of a competition-mediated pyrene-switching aptasensor for selective detection of Lys in buffer and human serum. pyrene 110-116 lysozyme Homo sapiens 165-168 21080638-4 2010 The detection strategy is based on the attachment of pyrene molecules to both ends of a hairpin DNA strand, which becomes the partially complementary competitor to an anti-Lys aptamer. pyrene 53-59 lysozyme Homo sapiens 172-175 21080638-5 2010 In the presence of target Lys, the aptamer hybridizes with part of the competitor, which opens the hairpin such that both pyrene molecules are spatially separated. pyrene 122-128 lysozyme Homo sapiens 26-29 20840854-0 2010 Non-dioxin-like PCBs interact with benzo[a]pyrene-induced p53-responses and inhibit apoptosis. pyrene 43-49 tumor protein p53 Homo sapiens 58-61 20973527-3 2010 We examine the effects of the PAH-substrate interaction on the oxidation of surface-adsorbed anthracene, pyrene, and benzo[a]pyrene by ozone (O(3)) using density functional theory. pyrene 105-111 phenylalanine hydroxylase Homo sapiens 30-33 20511593-9 2010 Cells deficient in TREX1 show reduced recovery from the UV and benzo(a)pyrene-induced replication inhibition and increased sensitivity towards the genotoxins compared to the isogenic control. pyrene 71-77 three prime repair exonuclease 1 Homo sapiens 19-24 20682247-6 2010 It is shown that dynamics measured by pyrene-labeled actin assays with varying Arp2/3 concentrations are equally well described by two different rate-limiting steps: 1), binding of a nucleating complex to the side of a preexisting filament; or 2), its subsequent activation. pyrene 38-44 actin related protein 2 Homo sapiens 79-83 20464547-3 2010 The major purposes of this study were to explore the roles of FGF-9 in the benzo(a)pyrene-induced lung cancer invasion in vitro and the metastatic development of lung adenocarcinoma in human. pyrene 83-89 fibroblast growth factor 9 Homo sapiens 62-67 20464547-10 2010 These present findings suggest that FGF-9 has potential roles in benzo(a)pyrene-induced CL5 cell invasion and human lung adenocarcinoma metastasis. pyrene 73-79 fibroblast growth factor 9 Homo sapiens 36-41 20478378-1 2010 We previously reported upregulation of aryl hydrocarbon receptor (AhR) expression as a mechanism by which overexpression of Cu/Zn-superoxide dismutase (SOD) and/or catalase accelerates benzo(a)pyrene (BaP) detoxification in mouse aorta endothelial cells (MAECs). pyrene 193-199 aryl-hydrocarbon receptor Mus musculus 39-64 20478378-1 2010 We previously reported upregulation of aryl hydrocarbon receptor (AhR) expression as a mechanism by which overexpression of Cu/Zn-superoxide dismutase (SOD) and/or catalase accelerates benzo(a)pyrene (BaP) detoxification in mouse aorta endothelial cells (MAECs). pyrene 193-199 aryl-hydrocarbon receptor Mus musculus 66-69 20478378-1 2010 We previously reported upregulation of aryl hydrocarbon receptor (AhR) expression as a mechanism by which overexpression of Cu/Zn-superoxide dismutase (SOD) and/or catalase accelerates benzo(a)pyrene (BaP) detoxification in mouse aorta endothelial cells (MAECs). pyrene 193-199 superoxide dismutase 1, soluble Mus musculus 152-155 20466593-6 2010 A significant decrease in oestradiol (P < 0.05) and AMH output (P < 0.001) by cultured follicles was induced by benzo[a]pyrene treatment, an effect attenuated by co-incubation with 3,4-DMF. pyrene 126-132 anti-Mullerian hormone Rattus norvegicus 55-58 20449256-2 2010 A tetramer ODF of pyrene deoxynucleosides displayed high quenching efficiency when conjugated via ester linkages with a dabcyl quencher, and yielded large signal increases with several enzymes in vitro and in intact human cells. pyrene 18-24 outer dense fiber of sperm tails 1 Homo sapiens 11-14 20158262-1 2010 A novel boron complex bearing a pyrene ligand (CPB) was synthesized and introduced as the first example of a binuclear boron complex in organic light-emitting diodes. pyrene 32-38 carboxypeptidase B1 Homo sapiens 47-50 20073510-0 2010 Pyrene fluorescence analysis offers new insights into the conformation of the lipoprotein-binding domain of human apolipoprotein E. pyrene 0-6 apolipoprotein E Homo sapiens 114-130 20073510-5 2010 Pyrene was covalently attached to single cysteine-containing recombinant human apoE CT at position 223 or 255 to probe the first predicted helical segment and at position 277 to monitor the terminal predicted helical segment. pyrene 0-6 apolipoprotein E Homo sapiens 79-83 20073510-6 2010 Regardless of the location of the probe, all three pyrene-labeled apoE CT variants display an intense and dramatic fluorescence excimer band at 460 nm, a signature feature of pyrene, which indicates that two pyrene moieties are within 10 A of each other. pyrene 51-57 apolipoprotein E Homo sapiens 66-70 20073510-6 2010 Regardless of the location of the probe, all three pyrene-labeled apoE CT variants display an intense and dramatic fluorescence excimer band at 460 nm, a signature feature of pyrene, which indicates that two pyrene moieties are within 10 A of each other. pyrene 175-181 apolipoprotein E Homo sapiens 66-70 20073510-6 2010 Regardless of the location of the probe, all three pyrene-labeled apoE CT variants display an intense and dramatic fluorescence excimer band at 460 nm, a signature feature of pyrene, which indicates that two pyrene moieties are within 10 A of each other. pyrene 175-181 apolipoprotein E Homo sapiens 66-70 19962752-1 2010 This work reported the G-quadruplex structure of pyrene-labeled G-rich DNA probe and its application in the immunoglobulin E (IgE) detection, providing plausibly an insight into the biological function of human telomere. pyrene 49-55 immunoglobulin heavy constant epsilon Homo sapiens 108-130 19786567-6 2010 The results of fluorescence experiments with pyrene-labeled apoA-I are consistent with the N-terminal helix bundle domain interacting with proteins resident on the HDL particle surface. pyrene 45-51 apolipoprotein A1 Homo sapiens 60-66 20432415-6 2010 A single-crystal X-ray diffraction analysis revealed that in the solid state the complex L.TNT consists of a supramolecular crystalline polymeric structure, the formation of which appears to be driven by intermolecular pi-pi interactions between two pyrene units and a TNT molecule held at a distance of 3.2-3.6 A, as well as by intra- and intermolecular hydrogen-bonds among the amide linkages. pyrene 250-256 chromosome 16 open reading frame 82 Homo sapiens 91-94 20387827-7 2010 It is the cyclodextrin/pyrene inclusion interaction that allows modulating the degree of conformational constraints of P1 and P2 and thus their background signals and selectivity. pyrene 23-29 crystallin gamma F, pseudogene Homo sapiens 119-128 20408978-1 2010 The photosensitized hole injection and guanine base damage phenomena have been investigated in the DNA sequence, 5"-d(CATG(1)(Py)CG(2)TCCTAC) with a site-specifically positioned pyrene-like (Py) benzo[a]pyrene 7,8-diol 9,10-epoxide-derived N(2)-guanine adduct (G(1)(Py)). pyrene 178-184 cathepsin G Homo sapiens 118-122 20371965-4 2010 Cotreatment with benzo[a]pyrene (BaP) or 3-methylchoranthrene (3-MC) decreased MDA-LDL-induced THP-1 cell growth, whereas treatment with benzo[e]pyrene (BeP) or pyrene, which is not a ligand for the arylhydrocarbon receptor (AhR), did not decrease THP-1 cell growth. pyrene 25-31 aryl hydrocarbon receptor Homo sapiens 199-223 20371965-4 2010 Cotreatment with benzo[a]pyrene (BaP) or 3-methylchoranthrene (3-MC) decreased MDA-LDL-induced THP-1 cell growth, whereas treatment with benzo[e]pyrene (BeP) or pyrene, which is not a ligand for the arylhydrocarbon receptor (AhR), did not decrease THP-1 cell growth. pyrene 25-31 aryl hydrocarbon receptor Homo sapiens 225-228 19382775-1 2009 The first systematic theoretical investigation of interactions of the Lewis acidic Rh(II) centers with a number of pi-ligands having isolated unsaturated carboncarbon bonds (acetylene and ethylene) or delocalized pi-systems with planar (benzene, naphthalene, acenaphthylene, and pyrene) or curved surfaces (corannulene and the C(3)-hemifullerene), including the C(60)-fullerene, has been undertaken. pyrene 279-285 Rh blood group D antigen Homo sapiens 83-89 20329538-8 2010 There is a significantly positive correlation relationship between F (rap) and b(w) (toluene: R2 = 0.982; pyrene: R2 = 0.991). pyrene 106-112 LDL receptor related protein associated protein 1 Homo sapiens 70-73 21036256-7 2010 We then provide a protocol to measure their activity toward the Arp2/3 complex using the well-established pyrene actin assay. pyrene 106-112 actin related protein 2 Homo sapiens 64-68 21255289-2 2009 To evaluate the thermodynamic constraints on methanogenic PAH degradation we have estimated the Gibbs free energy values for naphthalene, phenanthrene, anthracene, pyrene and chrysene in the aqueous phase, and used these values to evaluate several possible routes whereby PAHs may be converted to methane. pyrene 164-170 phenylalanine hydroxylase Homo sapiens 58-61 19463884-1 2009 Pyrene, benzo[a]pyrene (BaP), and indeno[1,2,3-cd]pyrene (IND) are poly cyclic aromatic hydrocarbons (PAHs) with four to six annealed phenyl rings. pyrene 0-6 prohibitin 2 Homo sapiens 24-27 19463884-5 2009 The degree of enhancement of Dex-induced transactivation of the GR by PAHs, BaP approximately IND>pyrene, paralleled the potency of PAHs in activating the AhR. pyrene 101-107 nuclear receptor subfamily 3 group C member 1 Homo sapiens 64-66 19354273-8 2009 The steady-state (particularly in the I(1)/I(3) ratio) and time-resolved fluorescence results indicate a contact between the pyrene groups and PEO, which then would imply that there may be an interaction, but much weaker than at low pH. pyrene 125-131 twinkle mtDNA helicase Homo sapiens 143-146 20060364-4 2010 The values of the rate constants are estimated by integrating these ODEs numerically and fitting them to a series of stopped-flow pyrene fluorescence transients of myosin-S1 fragment binding to regulated actin in solution. pyrene 130-136 myosin heavy chain 14 Homo sapiens 164-170 19889635-3 2010 We have studied the effect of a C-terminal fragment of CaD (H32K) on the kinetics of the in vitro actin polymerization by monitoring the fluorescence of pyrene-labeled actin. pyrene 153-159 caldesmon 1 Homo sapiens 55-58 19892394-0 2010 Benzo(a)pyrene induced glycine N-methyltransferase messenger RNA expression in Fundulus heteroclitus embryos. pyrene 8-14 glycine N-methyltransferase Fundulus heteroclitus 23-50 19584420-3 2009 Resonant Raman scattering (RRS) spectra also indicate that two of the pyrene derivatives, pb-18-C-6 and pc-18-C-6, are selective to large-diameter (D>1 nm) met-SWNTs. pyrene 70-76 complement C6 Homo sapiens 96-99 19584420-3 2009 Resonant Raman scattering (RRS) spectra also indicate that two of the pyrene derivatives, pb-18-C-6 and pc-18-C-6, are selective to large-diameter (D>1 nm) met-SWNTs. pyrene 70-76 complement C6 Homo sapiens 110-113 19563207-0 2009 Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. pyrene 92-98 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 40-59 19563207-6 2009 Pyrene itself was highly active in interacting with P450 1B1, but its binding was slightly decreased when substituted with acetylenic groups. pyrene 0-6 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 52-60 19386598-5 2009 However, Bnr1, but not Bni1, causes the polymerization of pyrene-labeled Mg-G-actin in G-buffer into single filaments based on fluorometric and EM observations. pyrene 58-64 formin BNR1 Saccharomyces cerevisiae S288C 9-13 19386598-8 2009 The interaction of Bnr1 with pyrene-labeled S265C Mg-actin yields a pyrene excimer peak, from the cross-strand interaction of pyrene probes, which only occurs in the context of F-actin. pyrene 29-35 formin BNR1 Saccharomyces cerevisiae S288C 19-23 19386598-8 2009 The interaction of Bnr1 with pyrene-labeled S265C Mg-actin yields a pyrene excimer peak, from the cross-strand interaction of pyrene probes, which only occurs in the context of F-actin. pyrene 68-74 formin BNR1 Saccharomyces cerevisiae S288C 19-23 19386598-8 2009 The interaction of Bnr1 with pyrene-labeled S265C Mg-actin yields a pyrene excimer peak, from the cross-strand interaction of pyrene probes, which only occurs in the context of F-actin. pyrene 68-74 formin BNR1 Saccharomyces cerevisiae S288C 19-23 19386598-13 2009 Finally, addition of Bnr1 but not Bni1 to pyrene-labeled wild type and S265C Mg-F actins enhanced the pyrene- and pyrene-excimer fluorescence, respectively, suggesting Bnr1 also alters F-actin structure. pyrene 102-108 formin BNR1 Saccharomyces cerevisiae S288C 21-25 19386598-13 2009 Finally, addition of Bnr1 but not Bni1 to pyrene-labeled wild type and S265C Mg-F actins enhanced the pyrene- and pyrene-excimer fluorescence, respectively, suggesting Bnr1 also alters F-actin structure. pyrene 102-108 formin BNR1 Saccharomyces cerevisiae S288C 21-25 18656336-0 2009 Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1. pyrene 37-43 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 18656336-0 2009 Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1. pyrene 37-43 transformation related protein 53, pseudogene Mus musculus 97-100 18656336-0 2009 Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1. pyrene 37-43 Harvey rat sarcoma virus oncogene Mus musculus 122-127 18656336-0 2009 Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1. pyrene 37-43 cyclin D1 Mus musculus 139-148 19225675-5 2009 The calculated results showed a considerable rotation of the pyrene moiety at U25 due to argininamide-induced conformational changes in the RNA bulge. pyrene 61-67 small nucleolar RNA, C/D box 25 Homo sapiens 78-81 19178928-9 2009 A common strong correlation between HLF/FLF and pyrene K(oc) was also observed for the UF fractions of the two HS, suggesting that HLF/FLF might serve as a good descriptor to predict the extent of pyrene binding independent of sediment source. pyrene 48-54 HLF transcription factor, PAR bZIP family member Homo sapiens 36-39 19178928-9 2009 A common strong correlation between HLF/FLF and pyrene K(oc) was also observed for the UF fractions of the two HS, suggesting that HLF/FLF might serve as a good descriptor to predict the extent of pyrene binding independent of sediment source. pyrene 48-54 HLF transcription factor, PAR bZIP family member Homo sapiens 131-134 19238985-7 2009 The most dominant PAH species monitored were fluoranthene and pyrene. pyrene 62-68 phenylalanine hydroxylase Homo sapiens 18-21 19124228-4 2009 The critical aggregation concentration (CAC) of the self-aggregate of LA modified CMCS (LCC) was determined by measuring the fluorescence intensity of the pyrene as a fluorescent probe. pyrene 155-161 G protein signaling modulator 2 Homo sapiens 82-86 18983977-3 2008 Employing ThT fluorescence, time-resolved fluorescence anisotropy of pyrene-labeled TTR, chemical cross-linking, and electron microscopy we demonstrated that early formed soluble oligomers (within minutes) from A-state TTR comprised on the average 20-30 TTR monomers. pyrene 69-75 transthyretin Homo sapiens 84-87 18826198-4 2008 We demonstrated that at this pressure pyrene I (P2(1)/a, 4 mol/unit cell) transforms to pyrene III (P2(1)/a, 2 mol/unit cell). pyrene 38-44 cyclin dependent kinase inhibitor 1A Homo sapiens 48-53 18950164-2 2008 The pyrene units closely resemble the well-known perylene bisimide dye PDI with regard to the ability to self-organize within a DNA duplex. pyrene 4-10 peptidyl arginine deiminase 1 Homo sapiens 71-74 19029401-3 2008 We investigated whether higher CYP2A6 activity results in the smoker extracting more nicotine (adjusting for cigarettes per day) and being exposed to higher levels of tobacco-specific nitrosamine [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)] and pyrene, a representative polycyclic aromatic hydrocarbon. pyrene 255-261 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 31-37 18831538-5 2008 Taking advantage of a significant increase in fluorescence when a pyrene-labeled helix is in contact with the lipid surface, we monitored the behaviors of the N- and C-terminal helices upon binding of apoA-I to egg PC small unilamellar vesicles. pyrene 66-72 apolipoprotein A1 Homo sapiens 201-207 18831538-6 2008 Comparison of the binding isotherms for pyrene-labeled apoA-I as well as a C-terminal helical peptide suggests that an increase in surface concentration of apoA-I causes dissociation of the N-terminal helix from the surface leaving the C-terminal helix attached. pyrene 40-46 apolipoprotein A1 Homo sapiens 55-61 18831538-6 2008 Comparison of the binding isotherms for pyrene-labeled apoA-I as well as a C-terminal helical peptide suggests that an increase in surface concentration of apoA-I causes dissociation of the N-terminal helix from the surface leaving the C-terminal helix attached. pyrene 40-46 apolipoprotein A1 Homo sapiens 156-162 18826198-4 2008 We demonstrated that at this pressure pyrene I (P2(1)/a, 4 mol/unit cell) transforms to pyrene III (P2(1)/a, 2 mol/unit cell). pyrene 38-44 cyclin dependent kinase inhibitor 1A Homo sapiens 100-105 18597818-4 2008 The ratios of fluoranthene to sum of fluoranthene and pyrene concentrations (Flt/(Flt+Pyr)) were more than 0.5 in 99% of vegetable soil samples, showing that the PAHs in soils were generally derived from straw and coal combustion sources. pyrene 54-60 fms related receptor tyrosine kinase 1 Homo sapiens 77-80 18781794-7 2008 The mobility of substrates encapsulated in the micellar core, estimated by pyrene fluorescence decay, is 95-121 ns for the micelles of the linear-dendritic copolymers and notably higher for PSt-PEO (152 ns), revealing the much denser interior of the linear analogue. pyrene 75-81 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Homo sapiens 190-193 18855977-0 2008 Depletion of CD4(+)CD25(+) regulatory T cells can promote local immunity to suppress tumor growth in benzo[a]pyrene-induced forestomach carcinoma. pyrene 109-115 CD4 antigen Mus musculus 13-16 18606741-4 2008 We expressed and purified the R108E and R108E/D293N mutants and compared their ability with that of native CYP2C9 to interact with (S)-warfarin, diclofenac, pyrene, propranolol, and ibuprofen amine. pyrene 157-163 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 107-113 18754635-5 2008 Our results show that the polarity of the hippocampal membrane is increased upon cholesterol depletion, as monitored by changes in the ratio of pyrene vibronic peak intensities (I1/I3). pyrene 144-150 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 178-183 18758120-1 2008 Based on the result of X-ray crystallographic analysis of our peroxisome proliferator-activated receptor alpha and delta (PPARalpha/delta) co-agonist complexed with human PPAR ligand binding domain (LBD), we designed and synthesized an optically active fluorescent PPARalpha/delta co-agonist, which has a pyrene unit incorporated directly at the hydrophobic tail part of the structure as a fluorophore. pyrene 305-311 peroxisome proliferator activated receptor alpha Homo sapiens 122-131 18675828-6 2008 Overall, UGT1A1-53 and -3156 genotypes modified the association between dietary benzo(a)pyrene (BaP) and colon cancer (P for interaction=0.02 and 0.03, respectively). pyrene 88-94 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 9-15 18311955-3 2008 Reaction of NO3 radicals with all three PAHs was observed to be very fast with the reactive uptake coefficient, gamma, ranging from 0.059 (+0.11/-0.049) for benz[a]anthracene at 273 K to 0.79 (+0.21/-0.67) for pyrene at room temperature. pyrene 210-216 NBL1, DAN family BMP antagonist Homo sapiens 12-15 18165874-0 2008 Effect of incubation conditions on the enrichment of pyrene-degrading bacteria identified by stable-isotope probing in an aged, PAH-contaminated soil. pyrene 53-59 phenylalanine hydroxylase Homo sapiens 128-131 18430445-0 2008 Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells. pyrene 97-103 RAD51 recombinase Homo sapiens 13-18 18430445-0 2008 Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells. pyrene 97-103 mitogen-activated protein kinase 14 Homo sapiens 37-40 18498184-6 2008 At high concentrations, the intensity ratio of the vibronic peaks of pyrene, I1/I3, (=0.68) is very close to published values for deoxycholate micelles, indicating that the probe is located in a region with a very low polarity and far from water. pyrene 69-75 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 77-82 18433772-0 2008 Multiparametric fluorescence detection of early stages in the amyloid protein aggregation of pyrene-labeled alpha-synuclein. pyrene 93-99 synuclein alpha Homo sapiens 108-123 18433772-5 2008 The approach involves tagging functionally neutral Ala-to-Cys variants of alpha-synuclein with the long-lifetime fluorophore pyrene. pyrene 125-131 synuclein alpha Homo sapiens 74-89 19035040-0 2008 [Effects of p53 in benzo (a) pyrene induced p21 and E2F-1 expression and cell cycle changes]. pyrene 29-35 tumor protein p53 L homeolog Xenopus laevis 12-15 19035040-0 2008 [Effects of p53 in benzo (a) pyrene induced p21 and E2F-1 expression and cell cycle changes]. pyrene 29-35 cyclin-dependent kinase inhibitor 1A L homeolog Xenopus laevis 44-47 19035040-0 2008 [Effects of p53 in benzo (a) pyrene induced p21 and E2F-1 expression and cell cycle changes]. pyrene 29-35 E2F transcription factor 1 L homeolog Xenopus laevis 52-57 18187423-0 2008 Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding. pyrene 90-96 cytochrome P450 1A2 Oryctolagus cuniculus 50-69 18187423-1 2008 Rabbit liver cytochrome P450 (P450) 1A2 was found to catalyze the 5,6-epoxidation of alpha-naphthoflavone (alphaNF), 1-hydroxylation of pyrene, and the subsequent 6-, 8-, and other hydroxylations of 1-hydroxy (OH) pyrene. pyrene 136-142 cytochrome P-450 Oryctolagus cuniculus 13-39 17991490-0 2007 The involvement of secondary signaling molecules in cytochrome P-450 1A1-mediated inducible nitric oxide synthase expression in benzo(a)pyrene-treated rat polymorphonuclear leukocytes. pyrene 136-142 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 52-72 18049780-7 2007 Pyrene is the most abundant particulate PAH in the Chinese restaurants (14-49%) while its contribution was much lower in the Western cooking style restaurants (10-22%). pyrene 0-6 phenylalanine hydroxylase Homo sapiens 40-43 19214762-3 2008 We have assigned this domain to the N-terminal part of the molecule combining, in the case of smooth muscle beta-Tm, DSC studies with measurements of temperature dependence of pyrene excimer fluorescence, whose decrease reflects dissociation of two beta-Tm chains in the region of pyrene-labeled Cys-36. pyrene 281-287 ATM serine/threonine kinase Homo sapiens 108-115 17991490-10 2007 The results demonstrated the involvement of [Ca(2+)]i, tyrosine kinase, inflammatory cytokines, and NF-kappaB in CYP1A1-mediated iNOS expression in benzo(a)pyrene-treated rat PMNs. pyrene 156-162 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 113-119 17991490-10 2007 The results demonstrated the involvement of [Ca(2+)]i, tyrosine kinase, inflammatory cytokines, and NF-kappaB in CYP1A1-mediated iNOS expression in benzo(a)pyrene-treated rat PMNs. pyrene 156-162 nitric oxide synthase 2 Rattus norvegicus 129-133 17991490-0 2007 The involvement of secondary signaling molecules in cytochrome P-450 1A1-mediated inducible nitric oxide synthase expression in benzo(a)pyrene-treated rat polymorphonuclear leukocytes. pyrene 136-142 nitric oxide synthase 2 Rattus norvegicus 82-113 17618724-0 2007 Pyrene-induced CYP1A2 and SULT1A1 may be regulated by CAR and not by AhR. pyrene 0-6 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 15-21 17803299-3 2007 Three stages of the complexation process are clearly shown by the pyrene I1/I3 variation of the complex systems, which only depends on the ratio of SDS/APU, and demonstrate that the process is dominated by electrostatic attraction and hydrophobic aggregation. pyrene 66-72 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 73-78 17618724-0 2007 Pyrene-induced CYP1A2 and SULT1A1 may be regulated by CAR and not by AhR. pyrene 0-6 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 26-33 17618724-6 2007 In contrast, pyrene exposure increased expression of the UGT1A1 and 1A6, and glucuronidation activities associated with 1-hydroxypyrene and 1-naphthol in the liver only in AhR (-/-) mice, although pyrene treatment dose-dependently decreased the latter activity. pyrene 13-19 UDP glucuronosyltransferase 1 family, polypeptide A1 Mus musculus 57-71 17618724-6 2007 In contrast, pyrene exposure increased expression of the UGT1A1 and 1A6, and glucuronidation activities associated with 1-hydroxypyrene and 1-naphthol in the liver only in AhR (-/-) mice, although pyrene treatment dose-dependently decreased the latter activity. pyrene 13-19 aryl-hydrocarbon receptor Mus musculus 172-175 17618724-6 2007 In contrast, pyrene exposure increased expression of the UGT1A1 and 1A6, and glucuronidation activities associated with 1-hydroxypyrene and 1-naphthol in the liver only in AhR (-/-) mice, although pyrene treatment dose-dependently decreased the latter activity. pyrene 129-135 UDP glucuronosyltransferase 1 family, polypeptide A1 Mus musculus 57-71 17618724-8 2007 In contrast, pyrene-induced expression of the hepatic constitutive androstane receptor (CAR) and one of its target genes, CYP2B10, in both AhR (+/+) and (-/-) mice. pyrene 13-19 nuclear receptor subfamily 1, group I, member 3 Mus musculus 54-86 17618724-8 2007 In contrast, pyrene-induced expression of the hepatic constitutive androstane receptor (CAR) and one of its target genes, CYP2B10, in both AhR (+/+) and (-/-) mice. pyrene 13-19 nuclear receptor subfamily 1, group I, member 3 Mus musculus 88-91 17618724-8 2007 In contrast, pyrene-induced expression of the hepatic constitutive androstane receptor (CAR) and one of its target genes, CYP2B10, in both AhR (+/+) and (-/-) mice. pyrene 13-19 cytochrome P450, family 2, subfamily b, polypeptide 10 Mus musculus 122-129 17618724-8 2007 In contrast, pyrene-induced expression of the hepatic constitutive androstane receptor (CAR) and one of its target genes, CYP2B10, in both AhR (+/+) and (-/-) mice. pyrene 13-19 aryl-hydrocarbon receptor Mus musculus 139-142 17618724-0 2007 Pyrene-induced CYP1A2 and SULT1A1 may be regulated by CAR and not by AhR. pyrene 0-6 nuclear receptor subfamily 1, group I, member 3 Mus musculus 54-57 17618724-2 2007 To determine whether pyrene-induced xenobiotic-metabolizing enzymes are regulated by AhR, male AhR (+/+) and (-/-) mice were used. pyrene 21-27 aryl-hydrocarbon receptor Mus musculus 85-88 17618724-4 2007 Exposure to pyrene did not influence hepatic CYP1A1-mRNA in mice of both genotypes, whereas it induced hepatic CYP1A2 protein and mRNA expression and associated 7-ethoxyresorufin O-deethylase and pyrene 1-hydroxylation activities in both AhR (+/+) and (-/-) mice. pyrene 12-18 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 111-117 17618724-4 2007 Exposure to pyrene did not influence hepatic CYP1A1-mRNA in mice of both genotypes, whereas it induced hepatic CYP1A2 protein and mRNA expression and associated 7-ethoxyresorufin O-deethylase and pyrene 1-hydroxylation activities in both AhR (+/+) and (-/-) mice. pyrene 12-18 aryl-hydrocarbon receptor Mus musculus 238-241 17655586-2 2007 STUDY DESIGN AND METHODS: The misfolded protein diagnostic (MPD) assay employs a pyrene-labeled palindromic sequence of prion peptides that undergoes a cascade of coil to beta-sheet conversion in the presence of the misfolded prion protein (PrP(TSE)). pyrene 81-87 mevalonate diphosphate decarboxylase Homo sapiens 60-63 17618724-9 2007 These results strongly suggest that pyrene-induced CYP1A2 and SULT1A1 are regulated by CAR, not by AhR. pyrene 36-42 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 51-57 17618724-9 2007 These results strongly suggest that pyrene-induced CYP1A2 and SULT1A1 are regulated by CAR, not by AhR. pyrene 36-42 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 62-69 17618724-9 2007 These results strongly suggest that pyrene-induced CYP1A2 and SULT1A1 are regulated by CAR, not by AhR. pyrene 36-42 nuclear receptor subfamily 1, group I, member 3 Mus musculus 87-90 17618724-9 2007 These results strongly suggest that pyrene-induced CYP1A2 and SULT1A1 are regulated by CAR, not by AhR. pyrene 36-42 aryl-hydrocarbon receptor Mus musculus 99-102 17618724-10 2007 However, the mechanisms of UGT1A1 and 1A6 induction by pyrene were not elucidated in this study. pyrene 55-61 UDP glucuronosyltransferase 1 family, polypeptide A1 Mus musculus 27-41 17655586-2 2007 STUDY DESIGN AND METHODS: The misfolded protein diagnostic (MPD) assay employs a pyrene-labeled palindromic sequence of prion peptides that undergoes a cascade of coil to beta-sheet conversion in the presence of the misfolded prion protein (PrP(TSE)). pyrene 81-87 prion protein Homo sapiens 241-244 17383120-0 2007 Phosphatidylinositol-3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo(a)pyrene-induced cell cycle alternation via cell cycle regulatory proteins in human embryo lung fibroblasts. pyrene 81-87 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 0-29 17625320-4 2007 When the indole moiety in PLT was changed to benzene, in forming a new fluoroionophore of N-[4-(1-pyrene)butyroyl]-L-phenylalanine (PLP), it could not form a pyrene dimer in response to Pb(2+) in water. pyrene 98-104 N-acylethanolamine acid amidase Homo sapiens 26-29 17908424-0 2007 [c-Jun NH2-terminal kinase and extracellular signal-regulated protein kinase signaling pathways in regulation of benzo(a)pyrene-induced c-Jun activation in human embryo lung fibroblasts]. pyrene 121-127 mitogen-activated protein kinase 8 Homo sapiens 1-26 17908424-0 2007 [c-Jun NH2-terminal kinase and extracellular signal-regulated protein kinase signaling pathways in regulation of benzo(a)pyrene-induced c-Jun activation in human embryo lung fibroblasts]. pyrene 121-127 mitogen-activated protein kinase 1 Homo sapiens 31-76 17908424-0 2007 [c-Jun NH2-terminal kinase and extracellular signal-regulated protein kinase signaling pathways in regulation of benzo(a)pyrene-induced c-Jun activation in human embryo lung fibroblasts]. pyrene 121-127 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 1-6 17575130-0 2007 Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice. pyrene 33-39 nuclear factor, erythroid derived 2, like 2 Mus musculus 73-77 17114645-1 2007 The objective of this study was to determine the effects of 5-lipoxygenase (5-LO) inhibitors on the incidence of benzo(a)pyrene-induced pulmonary adenomas in female A/J mice. pyrene 121-127 arachidonate 5-lipoxygenase Mus musculus 60-74 17357170-3 2007 On binding to CYP3A4, the fluorescence of the dansyl, deazaflavin, and pyrene probes is quenched by photophysical interaction of the fluorophore with the heme. pyrene 71-77 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 14-20 17383120-0 2007 Phosphatidylinositol-3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo(a)pyrene-induced cell cycle alternation via cell cycle regulatory proteins in human embryo lung fibroblasts. pyrene 81-87 AKT serine/threonine kinase 1 Homo sapiens 30-33 17383120-0 2007 Phosphatidylinositol-3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo(a)pyrene-induced cell cycle alternation via cell cycle regulatory proteins in human embryo lung fibroblasts. pyrene 81-87 ribosomal protein S6 kinase B1 Homo sapiens 34-40 17383120-0 2007 Phosphatidylinositol-3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo(a)pyrene-induced cell cycle alternation via cell cycle regulatory proteins in human embryo lung fibroblasts. pyrene 81-87 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 41-45 17350907-5 2007 In this study, we intended to determine the proximity relationship between the central helix of TnC and the TnT C-terminus in the binary and the ternary complex with and without Ca2+ by using pyrene excimer fluorescence spectroscopy and fluorescence resonance energy transfer. pyrene 192-198 tenascin C Gallus gallus 96-99 17552206-1 2007 A total of 10 bacterial strains represented as from SB01 to SB10 were isolated from a petrolium-contaminated sludge, and their potential of degrading pyrene (PYR) was investigated on the substrates pyrene (MS1) , pyrene plus glucose (MS2), and pyrene plus phenanthrene (MS3). pyrene 150-156 MS Homo sapiens 206-209 17309275-0 2007 Ratiometric determination of Hg2+ ions based on simple molecular motifs of pyrene and dioxaoctanediamide. pyrene 75-81 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 29-32 17309275-2 2007 Pyrene-appended dioxaoctanediamide 1 showed a selective fluorescence quenching toward Hg2+ ions over other transition-metal ions in an aqueous methanol solution. pyrene 0-6 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 86-89 17309275-3 2007 Unique responses in pyrene monomer and excimer emissions allowed selective ratiometric determination of Hg2+ ions in aqueous environments, and the detection limit was found to be 1.6 x 10(-6) M. [structure: see text] pyrene 20-26 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 104-107 16906435-8 2007 The inducing efficiency by PAHs differed extensively: control <or= naphthalene < phenanthrene, pyrene << chrysene < BaP. pyrene 101-107 prohibitin 2 Rattus norvegicus 131-134 17237483-0 2007 Growth kinetics in MCF-7 cells modulate benzo[a]pyrene-induced CYP1A1 up-regulation. pyrene 48-54 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 63-69 17552206-1 2007 A total of 10 bacterial strains represented as from SB01 to SB10 were isolated from a petrolium-contaminated sludge, and their potential of degrading pyrene (PYR) was investigated on the substrates pyrene (MS1) , pyrene plus glucose (MS2), and pyrene plus phenanthrene (MS3). pyrene 158-161 MS Homo sapiens 206-209 17048493-5 2006 The critical aggregation concentration (CAC) of PLC was determined by the fluorescence emission spectra of pyrene and was found to be 0.003 mg/ml. pyrene 107-113 heparan sulfate proteoglycan 2 Homo sapiens 48-51 17676574-1 2007 Water-soluble carbon-nanohorn-tetrathiafulvalene (CNH-TTF) nanoensembles were prepared by utilizing positively charged pyrene as an assembly medium and characterized by spectroscopy and electron microscopy. pyrene 119-125 ras homolog family member H Homo sapiens 54-57 17029827-3 2006 The p53 protein activation appeared to have been a downstream response to the benzo[a]pyrene-induced DNA damage, suggesting p53 plays important roles in the defense against benzo[a]pyrene-induced genotoxicity. pyrene 86-92 tumor protein p53 Homo sapiens 4-7 17029827-3 2006 The p53 protein activation appeared to have been a downstream response to the benzo[a]pyrene-induced DNA damage, suggesting p53 plays important roles in the defense against benzo[a]pyrene-induced genotoxicity. pyrene 86-92 tumor protein p53 Homo sapiens 124-127 17029827-3 2006 The p53 protein activation appeared to have been a downstream response to the benzo[a]pyrene-induced DNA damage, suggesting p53 plays important roles in the defense against benzo[a]pyrene-induced genotoxicity. pyrene 181-187 tumor protein p53 Homo sapiens 4-7 17029827-3 2006 The p53 protein activation appeared to have been a downstream response to the benzo[a]pyrene-induced DNA damage, suggesting p53 plays important roles in the defense against benzo[a]pyrene-induced genotoxicity. pyrene 181-187 tumor protein p53 Homo sapiens 124-127 17162569-2 2007 The degradation rates of PAH were in the order: acenaphthene > fluorene > phenanthrene > anthracene > pyrene. pyrene 114-120 phenylalanine hydroxylase Homo sapiens 25-28 17112560-3 2006 As part of a systematic analysis of mechanisms of PAH developmental toxicity in zebrafish, we show here that three tetracyclic PAHs (pyrene, chrysene, and benz[a]anthracene) activate the AHR pathway tissue-specifically to induce distinct patterns of CYP1A expression. pyrene 133-139 aryl hydrocarbon receptor 1a Danio rerio 187-190 17112560-3 2006 As part of a systematic analysis of mechanisms of PAH developmental toxicity in zebrafish, we show here that three tetracyclic PAHs (pyrene, chrysene, and benz[a]anthracene) activate the AHR pathway tissue-specifically to induce distinct patterns of CYP1A expression. pyrene 133-139 cytochrome P450, family 1, subfamily A Danio rerio 250-255 16953580-4 2006 We exploit the extreme sensitivity of the band III fluorescence emission peak of the pyrene fluorophore to the polarity of its microenvironment to monitor subtle conformational response of the alpha-syn acidic tail to Ca(2+). pyrene 85-91 synuclein alpha Homo sapiens 193-202 16953580-5 2006 Using recombinant human alpha-syn bearing a pyrene to probe either the N-terminal domain or the acidic tail, we noted that lipid binding resulted in an increase in band III emission intensity in the pyrene probe tagging the N-terminal domain but not that in the acidic tail. pyrene 44-50 synuclein alpha Homo sapiens 24-33 16953580-5 2006 Using recombinant human alpha-syn bearing a pyrene to probe either the N-terminal domain or the acidic tail, we noted that lipid binding resulted in an increase in band III emission intensity in the pyrene probe tagging the N-terminal domain but not that in the acidic tail. pyrene 199-205 synuclein alpha Homo sapiens 24-33 16800017-2 2006 The pyrene moiety in PYCD is located above the narrower rim of the alpha-CD and is fully exposed to water. pyrene 4-10 cathepsin K Homo sapiens 21-25 16502476-4 2006 We find that a nucleotide-like molecule with pyrene replacing the DNA base (dPTP) can be accepted as a substrate for this enzyme to produce discrete chromophores that have 3 or 4 pyrenes consecutively, depending on which anomer (alpha or beta) is used. pyrene 45-51 Protein tyrosine phosphatase 69D Drosophila melanogaster 76-80 16769251-7 2006 The metabolism of many exogenous compounds including benzo(a)pyrene (BaP), pyrene, ethoxyresorufin, ethoxycoumarin and aniline is mediated by P450 enzymes in tissues of marine invertebrates. pyrene 61-67 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 142-146 16786700-3 2006 We have previously found that phosphorylation of histone H2AX (gamma-H2AX), which accompanied the induction of DNA double strand breaks (DSBs), was significantly induced by low concentrations of benzo[a]pyrene (10(-9)-10(-7) M) and UVA (0.6 J/cm2) in CHO-K1 cells. pyrene 203-209 H2A.X variant histone Homo sapiens 49-61 16551675-8 2006 Airborne benzo(a)pyrene (BaP) correlated well (r(2) = 0.971) with levels of carcinogenic 4-6 ring PAHs and was an effective marker of exposure for all industries where significant particle bound PAH levels were found and, in particular, for CTPV exposure. pyrene 17-23 prohibitin 2 Homo sapiens 25-28 16541199-9 2006 The results obtained thus suggest that CYP1A1 induces iNOS expression leading to the generation of endogenous nitric oxide (NO) that could be responsible for the augmentation of myeloperoxidase-mediated benzo(a)pyrene-induced injury in PMNs. pyrene 211-217 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 39-45 16541199-9 2006 The results obtained thus suggest that CYP1A1 induces iNOS expression leading to the generation of endogenous nitric oxide (NO) that could be responsible for the augmentation of myeloperoxidase-mediated benzo(a)pyrene-induced injury in PMNs. pyrene 211-217 nitric oxide synthase 2 Rattus norvegicus 54-58 16541199-9 2006 The results obtained thus suggest that CYP1A1 induces iNOS expression leading to the generation of endogenous nitric oxide (NO) that could be responsible for the augmentation of myeloperoxidase-mediated benzo(a)pyrene-induced injury in PMNs. pyrene 211-217 myeloperoxidase Rattus norvegicus 178-193 16509750-3 2006 Synthetic fluorescent analogues of sP-B are used to investigate the peptide position and orientation in the intermembrane contacts: sP-Bw, an analogue that contains D-tryptophan (D-Trp) instead of the naturally occurring D-phenylalanine, and sP-Bpy, incorporating a pyrene group at the N-terminus. pyrene 266-272 surfactant protein B Homo sapiens 35-39 16377763-2 2006 Paradoxically, however, Cyp1a1-/- knockout mice are more sensitive to oral benzo[a]pyrene exposure, compared with wild-type Cyp1a1+/+ mice (Mol Pharmacol 65:1225, 2004). pyrene 83-89 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 24-30 16375931-0 2006 Benzo[a]pyrene-enhanced mutagenesis by man-made mineral fibres in the lung of lamda-lacI transgenic rats. pyrene 8-14 tissue factor pathway inhibitor Homo sapiens 84-88 16406622-0 2006 Inhibition of benzo(a)pyrene-induced cell cycle progression by all-trans retinoic acid partly through cyclin D1/E2F-1 pathway in human embryo lung fibroblasts. pyrene 22-28 cyclin D1 Homo sapiens 102-111 16326906-2 2006 Saturating cardiac tropomyosin (cTM) caused about a 20% increase in pyrene fluorescence of the doubly labeled F-actin but no change in WT actin C374 probe fluorescence. pyrene 68-74 actin Saccharomyces cerevisiae S288C 112-117 16489786-6 2006 The gradual decrease of I1/I3 and the appearance of excimer emission of pyrene in the concentration region between the two break points suggest the existence and growth of premicellar aggregates and the solubilization ability of pyrene. pyrene 229-235 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 24-29 16406622-0 2006 Inhibition of benzo(a)pyrene-induced cell cycle progression by all-trans retinoic acid partly through cyclin D1/E2F-1 pathway in human embryo lung fibroblasts. pyrene 22-28 E2F transcription factor 1 Homo sapiens 112-117 16600107-0 2006 [ERK and JNK/AP-1 pathways involved in benzo(a)pyrene induced cell cycle changes in human embryo lung fibroblasts]. pyrene 47-53 mitogen-activated protein kinase 1 Homo sapiens 1-4 16112127-5 2006 The Delta a has shown a linear correlation with the ratio of the fluorescence intensities of the first and the third vibronic peaks, I1/I3 of pyrene which is considered as a measure of the environmental polarity (herein micellar interior) of the probe (pyrene). pyrene 142-148 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 133-138 16112127-5 2006 The Delta a has shown a linear correlation with the ratio of the fluorescence intensities of the first and the third vibronic peaks, I1/I3 of pyrene which is considered as a measure of the environmental polarity (herein micellar interior) of the probe (pyrene). pyrene 253-259 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 133-138 16600107-0 2006 [ERK and JNK/AP-1 pathways involved in benzo(a)pyrene induced cell cycle changes in human embryo lung fibroblasts]. pyrene 47-53 mitogen-activated protein kinase 8 Homo sapiens 9-12 16118223-7 2005 The H372R substitution results in an increase in polymerization-dependent fluorescence of Cys-374 pyrene-labeled actin. pyrene 98-104 actin Saccharomyces cerevisiae S288C 113-118 16179355-6 2005 Myo9b-ATP appeared to be in a conformation with a weak affinity for actin as determined by pyrene-actin fluorescence. pyrene 91-97 myosin IXb Rattus norvegicus 0-5 16197980-1 2005 The biotransformation and mineralization of a mixture of two polycyclic aromatic hydrocarbons (PAHs), anthracene and pyrene, which are known contaminants of soil and groundwater, by an enrichment culture in the presence or absence of 100 mg l(-1) Tergitol NP-10, a non-ionic surfactant, and at temperatures of 10 degrees C and 25 degrees C were investigated. pyrene 117-123 nuclear receptor subfamily 4 group A member 1 Homo sapiens 256-261 16328660-7 2005 The time to 10% mineralization of added (14)C phenanthrene and (14)C pyrene was inversely correlated with the PAH content of the soils. pyrene 69-75 phenylalanine hydroxylase Homo sapiens 110-113 16328660-11 2005 Mineralization of phenanthrene and pyrene by all Danish soils suggests that soil microbial communities of inhabited areas possess a sufficiently high PAH degradation capacity to question the value of bioaugmentation with specific PAH degraders for bioremediation. pyrene 35-41 phenylalanine hydroxylase Homo sapiens 150-153 16671566-2 2005 Incubation of erythrocyte membranes with apolipoprotein A-I was accompanied by significant changes in biophysical characteristics of a fluorescent probe pyrene in the hydrophobic membrane region and a decrease in Na+/K(+)-ATPase activity. pyrene 153-159 apolipoprotein A1 Homo sapiens 41-59 16166335-1 2005 We previously showed that dietary treatment with the N-acetylcysteine conjugate of phenethyl isothiocyanate (PEITC-NAC) inhibited benzo(a)pyrene-induced lung tumorigenesis in A/J mice, and that tumor inhibition was associated with induction of activator protein-1 (AP-1) activity and stimulation of apoptosis in the lungs of mice. pyrene 138-144 NLR family, pyrin domain containing 1A Mus musculus 115-118 16186346-10 2005 Enhanced quenching of the single tryptophan residue of Tlc by pyrene and I(-) anion suggested that different protein domains are involved in the interaction of Tlc with oppositely charged lipid membranes. pyrene 62-68 lipocalin 1 Homo sapiens 55-58 16186346-10 2005 Enhanced quenching of the single tryptophan residue of Tlc by pyrene and I(-) anion suggested that different protein domains are involved in the interaction of Tlc with oppositely charged lipid membranes. pyrene 62-68 lipocalin 1 Homo sapiens 160-163 16193747-9 2005 The ratios of the C2- and C3-alkyl homologues of fluoranthene/pyrene and chrysene/benzo[a]anthracene are proposed as source ratios in moderately degraded oils. pyrene 62-68 complement C2 Homo sapiens 18-28 15936865-0 2005 Benzo(a)pyrene-induced anemia and splenomegaly in NZB/WF1 mice. pyrene 8-14 TP53 regulated inhibitor of apoptosis 1 Mus musculus 54-57 16105209-1 2005 Surface-enhanced micro-Raman spectroscopy (micro-SERS) was used to detect traces of the hazardous pollutant polycyclic aromatic hydrocarbons (PAHs) pyrene and benzo[c]phenanthrene deposited onto a calix[4]arene-functionalized Ag colloidal surface. pyrene 148-154 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 49-53 15963578-8 2005 Pyrene and CCl(4) caused opposite effects on expression of several genes, including HSP-27, macrophage receptor Marco, metalloproteinases (MMP9 and MMP13), and delta-6 fatty acid desaturase. pyrene 0-6 matrix metalloproteinase-9 Oncorhynchus mykiss 139-143 15979885-0 2005 Interaction of pyrene-end-capped poly(ethylene oxide) with bovine serum albumin and human serum albumin in aqueous buffer medium: a fluorometric study. pyrene 15-21 albumin Homo sapiens 66-79 15979885-0 2005 Interaction of pyrene-end-capped poly(ethylene oxide) with bovine serum albumin and human serum albumin in aqueous buffer medium: a fluorometric study. pyrene 15-21 albumin Homo sapiens 90-103 15979885-1 2005 The photophysical behavior of a hydrophobically tailored water-soluble polymer, pyrene-end-capped poly(ethylene oxide) (PYPY), has been studied in aqueous buffered bovine serum albumin (BSA) and human serum albumin (HSA) media. pyrene 80-86 albumin Homo sapiens 201-226 15993149-1 2005 In this study, the polycyclic aromatic hydrocarbons, benzo[a]pyrene (BaP) and pyrene, were subjected to temporal ozonation. pyrene 61-67 prohibitin 2 Rattus norvegicus 69-72 15888666-1 2005 Hepa-1c1c7 wild-type and benzo[a]pyrene-resistant derived mutant cell lines have been used to elucidate pathways and mechanisms involving the aryl hydrocarbon receptor (AhR). pyrene 33-39 aryl-hydrocarbon receptor Mus musculus 142-167 15888666-1 2005 Hepa-1c1c7 wild-type and benzo[a]pyrene-resistant derived mutant cell lines have been used to elucidate pathways and mechanisms involving the aryl hydrocarbon receptor (AhR). pyrene 33-39 aryl-hydrocarbon receptor Mus musculus 169-172 15913929-5 2005 Using pyrene (excitation 340 nm) as a hydrophobic fluorescent probe, a decrease in intensity peak I1 (374 nm)/I3 (385 nm) in the emission spectra (340-600 nm) was observed in the two dendrimers studied, fifth generation dendrimers with C10 or C12 surface lipidic chains, as the dendrimer concentration increased, reaching a plateau at higher concentrations, indicating that a more compact form of the aggregates with a more hydrophobic interior was obtained. pyrene 6-12 chromosome 12 open reading frame 57 Homo sapiens 236-239 15958554-6 2005 CYP1B1.7, having the amino acid substitutions Arg48Gly, Ala119Ser, Leu432Val, and Ala443Gly, exhibited a significantly decreased capacity (P < 0.001) for the formation of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol from benzo[a]pyrene as indicated by lower intrinsic clearance (Vmax/Km). pyrene 185-191 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 15969944-0 2005 Intratracheal budesonide-poly(lactide-co-glycolide) microparticles reduce oxidative stress, VEGF expression, and vascular leakage in a benzo(a)pyrene-fed mouse model. pyrene 143-149 vascular endothelial growth factor A Mus musculus 92-96 15952789-7 2005 Myosin V and myosin V-ADP binding to actin was assayed from the quenching of pyrene actin fluorescence. pyrene 77-83 myosin VA Homo sapiens 0-8 15952789-7 2005 Myosin V and myosin V-ADP binding to actin was assayed from the quenching of pyrene actin fluorescence. pyrene 77-83 myosin VA Homo sapiens 13-21 15910734-0 2005 Catalytic turnover of pyrene by CYP3A4: evidence that cytochrome b5 directly induces positive cooperativity. pyrene 22-28 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 32-38 15910734-0 2005 Catalytic turnover of pyrene by CYP3A4: evidence that cytochrome b5 directly induces positive cooperativity. pyrene 22-28 cytochrome b5 type A Homo sapiens 54-67 15910734-1 2005 The metabolism of pyrene to hydroxypyrene by CYP3A4 was investigated to determine the effect of cytochrome b5 (b5) on turnover kinetics. pyrene 18-24 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 45-51 16032844-7 2005 The partition equilibrium constants (Kv) of pyrene in the micellar solution increased by increasing the size of the dendritic block, for example, 6.17 x 10(4) for PEG-2GOc and 1.58 x 10(5) for PEG-3GOc. pyrene 44-50 mesoderm specific transcript Homo sapiens 163-177 15661830-3 2005 Using fluorophore-labeled ERalpha-LBDs, we present evidence for a pronounced stabilization of ER conformation that results from coactivator binding, manifest by decreased ER sensitivity to proteases and reduced conformational dynamics, as well as for the formation of a novel coactivator-stabilized (costabilized) receptor conformation, that can be conveniently monitored by the generation of an excimer emission from pyrene-labeled ERalpha-LBDs. pyrene 418-424 estrogen receptor 1 Homo sapiens 26-28 15661830-3 2005 Using fluorophore-labeled ERalpha-LBDs, we present evidence for a pronounced stabilization of ER conformation that results from coactivator binding, manifest by decreased ER sensitivity to proteases and reduced conformational dynamics, as well as for the formation of a novel coactivator-stabilized (costabilized) receptor conformation, that can be conveniently monitored by the generation of an excimer emission from pyrene-labeled ERalpha-LBDs. pyrene 418-424 estrogen receptor 1 Homo sapiens 94-96 16851934-9 2005 The bimolecular collision rate as deduced from fluorescence quenching of pyrene by dodecylpyridinium chloride conforms well to a hydrodynamic description, varying linearly with T/eta, where T is the absolute temperature and passing through the origin. pyrene 73-79 endothelin receptor type A Homo sapiens 179-182 15829353-0 2005 Lysozyme effect on structural state of model membranes as revealed by pyrene excimerization studies. pyrene 70-76 lysozyme Homo sapiens 0-8 15805253-0 2005 p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors. pyrene 25-31 tumor protein p53 Homo sapiens 0-3 15708851-0 2005 Examination of lipid-bound conformation of apolipoprotein E4 by pyrene excimer fluorescence. pyrene 64-70 apolipoprotein E Homo sapiens 43-60 15708851-8 2005 Pyrene excimer fluorescence was noted in lipid-free pyrene-R61C/E255C/apoE4 in mixtures containing excess wild-type apoE4, which was attributed to intramolecular spatial proximity between these specified sites. pyrene 0-6 apolipoprotein E Homo sapiens 70-75 15708851-8 2005 Pyrene excimer fluorescence was noted in lipid-free pyrene-R61C/E255C/apoE4 in mixtures containing excess wild-type apoE4, which was attributed to intramolecular spatial proximity between these specified sites. pyrene 0-6 apolipoprotein E Homo sapiens 116-121 15708851-8 2005 Pyrene excimer fluorescence was noted in lipid-free pyrene-R61C/E255C/apoE4 in mixtures containing excess wild-type apoE4, which was attributed to intramolecular spatial proximity between these specified sites. pyrene 52-58 apolipoprotein E Homo sapiens 70-75 15708851-8 2005 Pyrene excimer fluorescence was noted in lipid-free pyrene-R61C/E255C/apoE4 in mixtures containing excess wild-type apoE4, which was attributed to intramolecular spatial proximity between these specified sites. pyrene 52-58 apolipoprotein E Homo sapiens 116-121 15708851-9 2005 Upon disruption of tertiary interaction, a large decrease in excimer fluorescence emission was noted in pyrene-R61C/E255C/apoE4. pyrene 104-110 apolipoprotein E Homo sapiens 122-127 15708851-10 2005 In dimyristoylphosphatidylcholine/pyrene-R61C/E255C/apoE4 discoidal complexes, pyrene excimer fluorescence emission was retained. pyrene 34-40 apolipoprotein E Homo sapiens 52-57 15708851-10 2005 In dimyristoylphosphatidylcholine/pyrene-R61C/E255C/apoE4 discoidal complexes, pyrene excimer fluorescence emission was retained. pyrene 79-85 apolipoprotein E Homo sapiens 52-57 15805253-0 2005 p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors. pyrene 25-31 tumor protein p53 Homo sapiens 46-49 15805253-0 2005 p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors. pyrene 25-31 transformation related protein 53, pseudogene Mus musculus 46-49 15781611-2 2005 NQO1-null mice deficient in NQO1 protein showed increased sensitivity to 7,12-dimethylbenz(a)anthracene- and benzo(a)pyrene-induced skin carcinogenesis. pyrene 117-123 NAD(P)H dehydrogenase, quinone 1 Mus musculus 0-4 15839563-1 2005 Influence of ionic strength (I) on the pyrene binding constant (Koc) in six different humic substance (HS) solutions, three soil humic acids, one freshwater humic acid, one freshwater fulvic acid, and one freshwater natural organic matter was investigated by fluorescence quenching technique. pyrene 39-45 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 64-67 15781611-3 2005 In the present studies, we show that benzo(a)pyrene metabolite benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide and not benzo(a)pyrene quinones contributed to increased benzo(a) pyrene-induced skin tumors in NQO1-null mice. pyrene 71-77 NAD(P)H dehydrogenase, quinone 1 Mus musculus 209-213 15781611-2 2005 NQO1-null mice deficient in NQO1 protein showed increased sensitivity to 7,12-dimethylbenz(a)anthracene- and benzo(a)pyrene-induced skin carcinogenesis. pyrene 117-123 NAD(P)H dehydrogenase, quinone 1 Mus musculus 28-32 15781611-6 2005 These results led to the conclusion that altered intracellular redox state along with lack of induction of p53 and decreased apoptosis plays a significant role in increased sensitivity of NQO1-null mice to benzo(a)pyrene-induced skin cancer. pyrene 214-220 NAD(P)H dehydrogenase, quinone 1 Mus musculus 188-192 15781611-3 2005 In the present studies, we show that benzo(a)pyrene metabolite benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide and not benzo(a)pyrene quinones contributed to increased benzo(a) pyrene-induced skin tumors in NQO1-null mice. pyrene 45-51 NAD(P)H dehydrogenase, quinone 1 Mus musculus 209-213 15723529-7 2005 Quenching by endostatin of the fluorescence of a pyrene-labeled phospholipid analogue in PS containing membranes was seen, while there was no effect for PC liposomes. pyrene 49-55 collagen type XVIII alpha 1 chain Homo sapiens 13-23 16851466-3 2005 It was shown that the addition of hydrophobic molecules to the pyrene-containing interface results in a significant decrease in the pyrene I1/I3 vibronic emission band ratio and an increase in the water drop contact angle due to increased hydrophobicity of the interface. pyrene 63-69 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 139-144 16851466-3 2005 It was shown that the addition of hydrophobic molecules to the pyrene-containing interface results in a significant decrease in the pyrene I1/I3 vibronic emission band ratio and an increase in the water drop contact angle due to increased hydrophobicity of the interface. pyrene 132-138 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 139-144 15762640-2 2005 Dehydrogenated polymers (DHP = coniferyl alcohol polymers = synthetic lignin) interact with pectin to form hydrophobic clusters as monitored by pyrene fluorescence spectroscopy. pyrene 144-150 dihydropyrimidinase Homo sapiens 25-28 15740184-2 2005 The binding energy of PAH clusters ranging in size from the benzene dimer to the pyrene dimer obtained by ab initio calculations at the MP2 level was used to extract the pair potentials in the form of the Lennard-Jones and Exponential-6 functions. pyrene 81-87 tryptase pseudogene 1 Homo sapiens 136-139 16833368-1 2005 Using density functional theory, we have theoretically studied the formation of neutral lithium-aromatic complexes R-nLi and R-nLi-R, where R is benzene, naphthalene, or pyrene. pyrene 170-176 LIM domain binding 1 Homo sapiens 127-130 15854413-0 2005 [Roles of mutant p53 gene in malignant phenotypes and resistance to drugs in anti-7,8-dihydrodiol-9,10-epoxide benzo(a)pyrene-induced lung cancer cells]. pyrene 119-125 tumor protein p53 Homo sapiens 17-20 15670604-1 2005 I have monitored equilibrium binding of human cofilin to rabbit skeletal muscle (alpha) and human non-muscle (85% beta, 15% gamma) actin filaments from the quenching of pyrene actin fluorescence. pyrene 169-175 cofilin 1 Homo sapiens 46-53 15601657-7 2005 This reduced number of cells with pol(kappa) foci, when compared with those containing pol(eta) foci, is observed both in untreated cells and in cells treated with hydroxyurea, UV irradiation or benzo[a]pyrene. pyrene 203-209 DNA polymerase lambda Homo sapiens 34-44 15626640-7 2005 Liquid chromatography-mass spectrometry analysis confirmed the microbial PAH transformation by the detection of PAH metabolites 1-hydroxypyrene and 7-hydroxybenzo(a)pyrene in colon digests of pyrene and benzo(a)pyrene. pyrene 137-143 phenylalanine hydroxylase Homo sapiens 73-76 15626640-7 2005 Liquid chromatography-mass spectrometry analysis confirmed the microbial PAH transformation by the detection of PAH metabolites 1-hydroxypyrene and 7-hydroxybenzo(a)pyrene in colon digests of pyrene and benzo(a)pyrene. pyrene 137-143 phenylalanine hydroxylase Homo sapiens 112-115 15509633-10 2004 Paving task, RAP content and crew were also found to be significant determinants of inhalation and dermal exposure to pyrene. pyrene 118-124 LDL receptor related protein associated protein 1 Homo sapiens 13-16 16465887-4 2005 The log Koc values obtained of each soil and its particle-size fractions were similar, proving that SOM content was a key factor affecting pyrene sorption. pyrene 139-145 grainyhead like transcription factor 3 Homo sapiens 100-103 15595848-0 2004 Mutagenic potential of benzo[a]pyrene-derived DNA adducts positioned in codon 273 of the human P53 gene. pyrene 31-37 tumor protein p53 Homo sapiens 95-98 15606950-3 2004 SERS spectra of pyrene adsorbed to C18-modified immobilized silver colloids are dominated by Raman bands that are not consistent with pyrene and indicate that pyrene undergoes a chemical reaction at the surface. pyrene 16-22 Bardet-Biedl syndrome 9 Homo sapiens 35-38 15606950-3 2004 SERS spectra of pyrene adsorbed to C18-modified immobilized silver colloids are dominated by Raman bands that are not consistent with pyrene and indicate that pyrene undergoes a chemical reaction at the surface. pyrene 134-140 Bardet-Biedl syndrome 9 Homo sapiens 35-38 15606950-3 2004 SERS spectra of pyrene adsorbed to C18-modified immobilized silver colloids are dominated by Raman bands that are not consistent with pyrene and indicate that pyrene undergoes a chemical reaction at the surface. pyrene 134-140 Bardet-Biedl syndrome 9 Homo sapiens 35-38 15606950-5 2004 When a C18-modified gold-colloid substrate is used, Raman scattering consistent with unreacted pyrene is observed. pyrene 95-101 Bardet-Biedl syndrome 9 Homo sapiens 7-10 15606950-6 2004 The adsorption and detection of pyrene adsorbed from low (2 ppb) concentration aqueous solutions onto C18-modified gold-colloid substrates is reported; naphthalene and phenanthrene are detected at approximately 5 ppb. pyrene 32-38 Bardet-Biedl syndrome 9 Homo sapiens 102-105 15342368-0 2004 Deficiency of NRH:quinone oxidoreductase 2 increases susceptibility to 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene-induced skin carcinogenesis. pyrene 114-120 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 14-42 15632309-1 2004 We have conducted a study of the effects of increasing acidity on the Ca(2+) induced conformational changes of pyrene labelled cardiac troponin C (PIA-cTnC) in isolation and in complex with porcine cardiac or chicken pectoral skeletal muscle TnI and/or TnT. pyrene 111-117 troponin C1, slow skeletal and cardiac type Gallus gallus 127-145 15632309-2 2004 The pyrene label has been shown to serve as a useful fluorescence reporter group for conformational and interaction events of the N-terminal regulatory domain of TnC with only minimal fluorescence changes associated with C-terminal domain. pyrene 4-10 tenascin C Gallus gallus 162-165 15336901-7 2004 For example, the average logKoc value of ship channel pyrene was significantly lower than that of creosote facility pyrene (4.39 +/- 0.35 and 5.29 +/- 0.09, respectively, when tested in 5 mM calcium chloride). pyrene 54-60 inositol polyphosphate-5-phosphatase D Homo sapiens 41-45 15336901-8 2004 These results were consistent with the greater desorption of pyrene, phenanthrene and benzo(a)pyrene from the ship channel than from the creosote facility sediments. pyrene 61-67 inositol polyphosphate-5-phosphatase D Homo sapiens 110-114 15342368-10 2004 These results demonstrate that NQO2 protects against DMBA- and benzo(a)pyrene-induced skin carcinogenesis and suggest that NQO2 protection might be against tumor promotion. pyrene 71-77 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 31-35 15198606-7 2004 The Sc(OTf)(3)-promoted photoinduced electron transfer from hexamethylbenzene to the singlet excited state of acridine or pyrene leads to efficient oxygenation of hexamethylbenzene to produce pentamethylbenzyl alcohol which is further oxygenated under prolonged photoirradiation of an O(2)-saturated acetonitrile solution of hexamethylbenzene in the presence of acridine or pyrene which acts as a photocatalyst together with Sc(OTf)(3). pyrene 374-380 POU class 5 homeobox 1 Homo sapiens 4-14 15296456-1 2004 Conversion of hydrophobic substrates such as polyaromatic hydrocarbons (PAHs) was studied in aqueous-organic media using transformation of pyrene by cytochrome c. pyrene 139-145 cytochrome c, somatic Homo sapiens 149-161 15198606-2 2004 Photoinduced electron transfer from a variety of electron donors including alkylbenzenes to the singlet excited state of acridine and pyrene is accelerated significantly by the presence of scandium triflate [Sc(OTf)(3)] in acetonitrile, whereas no photoinduced electron transfer from alkylbenzenes to the singlet excited state of acridine or pyrene takes place in the absence of Sc(OTf)(3). pyrene 134-140 POU class 5 homeobox 1 Homo sapiens 208-218 15198606-2 2004 Photoinduced electron transfer from a variety of electron donors including alkylbenzenes to the singlet excited state of acridine and pyrene is accelerated significantly by the presence of scandium triflate [Sc(OTf)(3)] in acetonitrile, whereas no photoinduced electron transfer from alkylbenzenes to the singlet excited state of acridine or pyrene takes place in the absence of Sc(OTf)(3). pyrene 134-140 POU class 5 homeobox 1 Homo sapiens 208-217 15198606-2 2004 Photoinduced electron transfer from a variety of electron donors including alkylbenzenes to the singlet excited state of acridine and pyrene is accelerated significantly by the presence of scandium triflate [Sc(OTf)(3)] in acetonitrile, whereas no photoinduced electron transfer from alkylbenzenes to the singlet excited state of acridine or pyrene takes place in the absence of Sc(OTf)(3). pyrene 342-348 POU class 5 homeobox 1 Homo sapiens 208-218 15198606-2 2004 Photoinduced electron transfer from a variety of electron donors including alkylbenzenes to the singlet excited state of acridine and pyrene is accelerated significantly by the presence of scandium triflate [Sc(OTf)(3)] in acetonitrile, whereas no photoinduced electron transfer from alkylbenzenes to the singlet excited state of acridine or pyrene takes place in the absence of Sc(OTf)(3). pyrene 342-348 POU class 5 homeobox 1 Homo sapiens 208-217 15198606-4 2004 In contrast to the case of acridine, the k(et) value of the Sc(OTf)(3)-promoted photoinduced electron transfer of pyrene increases with an increase in concentration of Sc(OTf)(3) to exhibit first-order dependence on [Sc(OTf)(3)] at low concentrations, changing to second-order dependence at high concentrations. pyrene 114-120 POU class 5 homeobox 1 Homo sapiens 60-70 15198606-4 2004 In contrast to the case of acridine, the k(et) value of the Sc(OTf)(3)-promoted photoinduced electron transfer of pyrene increases with an increase in concentration of Sc(OTf)(3) to exhibit first-order dependence on [Sc(OTf)(3)] at low concentrations, changing to second-order dependence at high concentrations. pyrene 114-120 POU class 5 homeobox 1 Homo sapiens 60-69 15198606-4 2004 In contrast to the case of acridine, the k(et) value of the Sc(OTf)(3)-promoted photoinduced electron transfer of pyrene increases with an increase in concentration of Sc(OTf)(3) to exhibit first-order dependence on [Sc(OTf)(3)] at low concentrations, changing to second-order dependence at high concentrations. pyrene 114-120 POU class 5 homeobox 1 Homo sapiens 168-178 15527074-0 2004 Hot-water extracts from adzuki beans (Vigna angularis) suppress not only the proliferation of KATO III cells in culture but also benzo(a)pyrene-induced tumorigenesis in mouse forestomatch. pyrene 137-143 alcohol dehydrogenase iron containing 1 Homo sapiens 0-3 15198606-7 2004 The Sc(OTf)(3)-promoted photoinduced electron transfer from hexamethylbenzene to the singlet excited state of acridine or pyrene leads to efficient oxygenation of hexamethylbenzene to produce pentamethylbenzyl alcohol which is further oxygenated under prolonged photoirradiation of an O(2)-saturated acetonitrile solution of hexamethylbenzene in the presence of acridine or pyrene which acts as a photocatalyst together with Sc(OTf)(3). pyrene 374-380 POU class 5 homeobox 1 Homo sapiens 425-435 14988465-0 2004 Beta-carotene and beta-apo-14"-carotenoic acid prevent the reduction of retinoic acid receptor beta in benzo[a]pyrene-treated normal human bronchial epithelial cells. pyrene 111-117 retinoic acid receptor beta Homo sapiens 72-99 15150120-0 2004 Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway. pyrene 69-75 glycine N-methyltransferase Homo sapiens 0-27 15057875-1 2004 Transformation of the human breast epithelial cells (HBEC) MCF-10F with the carcinogen benz(a)pyrene (BP) into BP1-E cells resulted in the loss of the chromosome 17 p13.2 locus (D17S796 marker) and formation of colonies in agar-methocel (colony efficiency (CE)), loss of ductulogenic capacity in collagen matrix, and resistance to anti-Fas monoclonal antibody (Mab)-induced apoptosis. pyrene 94-100 BP1 Homo sapiens 111-114 15006402-2 2004 Determining the influence of the nature, position and linkage of the label on the in vitro phosphorylation rate by sphingosine kinases 1 and 2 resulted in the identification of a pyrene- and a NBD-labeled sphingosine which are both phosphorylated with efficiency comparable to the natural substrate. pyrene 179-185 sphingosine kinase 1 Homo sapiens 115-142 15001354-3 2004 Cofilin inhibited several-fold the rate of interstrand disulfide cross-linking between Cys265 and Cys374 in yeast S265C mutant F-actin, but enhanced excimer formation between pyrene probes attached to these cysteine residues. pyrene 175-181 cofilin Saccharomyces cerevisiae S288C 0-7 15198606-5 2004 The first-order and second-order dependence of k(et) on [Sc(OTf)(3)] is ascribed to the 1:1 and 1:2 complexes formation between pyrene radical anion and Sc(OTf)(3). pyrene 128-134 POU class 5 homeobox 1 Homo sapiens 57-67 15198606-5 2004 The first-order and second-order dependence of k(et) on [Sc(OTf)(3)] is ascribed to the 1:1 and 1:2 complexes formation between pyrene radical anion and Sc(OTf)(3). pyrene 128-134 POU class 5 homeobox 1 Homo sapiens 153-163 15198606-6 2004 The positive shifts of the one-electron redox potentials for the couple between the singlet excited state and the ground-state radical anion of acridine and pyrene in the presence of Sc(OTf)(3) as compared to those in the absence of Sc(OTf)(3) have been determined by adapting the free energy relationship for the photoinduced electron-transfer reactions. pyrene 157-163 POU class 5 homeobox 1 Homo sapiens 183-193 15198606-6 2004 The positive shifts of the one-electron redox potentials for the couple between the singlet excited state and the ground-state radical anion of acridine and pyrene in the presence of Sc(OTf)(3) as compared to those in the absence of Sc(OTf)(3) have been determined by adapting the free energy relationship for the photoinduced electron-transfer reactions. pyrene 157-163 POU class 5 homeobox 1 Homo sapiens 233-243 15198606-7 2004 The Sc(OTf)(3)-promoted photoinduced electron transfer from hexamethylbenzene to the singlet excited state of acridine or pyrene leads to efficient oxygenation of hexamethylbenzene to produce pentamethylbenzyl alcohol which is further oxygenated under prolonged photoirradiation of an O(2)-saturated acetonitrile solution of hexamethylbenzene in the presence of acridine or pyrene which acts as a photocatalyst together with Sc(OTf)(3). pyrene 122-128 POU class 5 homeobox 1 Homo sapiens 4-14 15198606-7 2004 The Sc(OTf)(3)-promoted photoinduced electron transfer from hexamethylbenzene to the singlet excited state of acridine or pyrene leads to efficient oxygenation of hexamethylbenzene to produce pentamethylbenzyl alcohol which is further oxygenated under prolonged photoirradiation of an O(2)-saturated acetonitrile solution of hexamethylbenzene in the presence of acridine or pyrene which acts as a photocatalyst together with Sc(OTf)(3). pyrene 122-128 POU class 5 homeobox 1 Homo sapiens 425-435 15144225-6 2004 This benzo[a]pyrene-induced osteoblast proliferation could be inhibited by the estrogen receptor antagonist ICI182780 and tamoxifen, PD98059 [extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) inhibitor], and LY294002 [phosphatidylinositol 3-kinase (PI3K) inhibitor] but not alpha-naphthoflavone (aryl hydrocarbon receptor antagonist) and SB203580 (p38 MAPK inhibitor). pyrene 13-19 mitogen-activated protein kinase 1 Homo sapiens 142-179 15144225-6 2004 This benzo[a]pyrene-induced osteoblast proliferation could be inhibited by the estrogen receptor antagonist ICI182780 and tamoxifen, PD98059 [extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) inhibitor], and LY294002 [phosphatidylinositol 3-kinase (PI3K) inhibitor] but not alpha-naphthoflavone (aryl hydrocarbon receptor antagonist) and SB203580 (p38 MAPK inhibitor). pyrene 13-19 mitogen-activated protein kinase 1 Homo sapiens 181-184 15144225-6 2004 This benzo[a]pyrene-induced osteoblast proliferation could be inhibited by the estrogen receptor antagonist ICI182780 and tamoxifen, PD98059 [extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) inhibitor], and LY294002 [phosphatidylinositol 3-kinase (PI3K) inhibitor] but not alpha-naphthoflavone (aryl hydrocarbon receptor antagonist) and SB203580 (p38 MAPK inhibitor). pyrene 13-19 mitogen-activated protein kinase 3 Homo sapiens 220-224 15144225-6 2004 This benzo[a]pyrene-induced osteoblast proliferation could be inhibited by the estrogen receptor antagonist ICI182780 and tamoxifen, PD98059 [extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) inhibitor], and LY294002 [phosphatidylinositol 3-kinase (PI3K) inhibitor] but not alpha-naphthoflavone (aryl hydrocarbon receptor antagonist) and SB203580 (p38 MAPK inhibitor). pyrene 13-19 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 252-281 15144225-6 2004 This benzo[a]pyrene-induced osteoblast proliferation could be inhibited by the estrogen receptor antagonist ICI182780 and tamoxifen, PD98059 [extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) inhibitor], and LY294002 [phosphatidylinositol 3-kinase (PI3K) inhibitor] but not alpha-naphthoflavone (aryl hydrocarbon receptor antagonist) and SB203580 (p38 MAPK inhibitor). pyrene 13-19 aryl hydrocarbon receptor Homo sapiens 330-355 15065866-3 2004 Utilizing the fluorescence signal on binding of myosin to pyrene-labeled actin filaments, we investigated the interplay of actin and nucleotide binding to thiophosphorylated and unphosphorylated recombinant nonmuscle IIA heavy meromyosin constructs. pyrene 58-64 myosin heavy chain 14 Homo sapiens 48-54 15016593-4 2004 The pyrene 1-hydroxylation activity was found to be the highest in CYP1A1 at both 0.5 and 50microM of pyrene, followed by CYP1B1 and 1A2, whereas other enzymes, including CYP2A6, 2C8, 2C9*1, 2C19, 2D6, 2E1, 3A4, and control microsomes, showed very low or undetectable rates of 1-hydroxylation. pyrene 4-10 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 67-73 15016593-4 2004 The pyrene 1-hydroxylation activity was found to be the highest in CYP1A1 at both 0.5 and 50microM of pyrene, followed by CYP1B1 and 1A2, whereas other enzymes, including CYP2A6, 2C8, 2C9*1, 2C19, 2D6, 2E1, 3A4, and control microsomes, showed very low or undetectable rates of 1-hydroxylation. pyrene 4-10 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 122-136 15016593-4 2004 The pyrene 1-hydroxylation activity was found to be the highest in CYP1A1 at both 0.5 and 50microM of pyrene, followed by CYP1B1 and 1A2, whereas other enzymes, including CYP2A6, 2C8, 2C9*1, 2C19, 2D6, 2E1, 3A4, and control microsomes, showed very low or undetectable rates of 1-hydroxylation. pyrene 4-10 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 171-177 15016593-4 2004 The pyrene 1-hydroxylation activity was found to be the highest in CYP1A1 at both 0.5 and 50microM of pyrene, followed by CYP1B1 and 1A2, whereas other enzymes, including CYP2A6, 2C8, 2C9*1, 2C19, 2D6, 2E1, 3A4, and control microsomes, showed very low or undetectable rates of 1-hydroxylation. pyrene 102-108 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 67-73 15016593-5 2004 In conclusion, CYP1A1, 1B1, and 1A2 are major metabolizing enzymes in 1-hydroxylation of pyrene in vitro. pyrene 89-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-26 14520510-1 2004 The aim of this study was to investigate the electrophilic tissue burden (ETB) formation, assessed as covalent binding of the ultimate carcinogen benzo( a)pyrene diolepoxide (BaPDE) with cellular proteins, in liver, lung and heart, as well as with haemoglobin (Hb) following repeated exposure to binary mixtures of benzo( a)pyrene (BaP) and pyrene (P). pyrene 155-161 prohibitin 2 Rattus norvegicus 175-178 14660556-4 2004 Changes in pyrene-actin fluorescence during polymerization and depolymerization were measured with actin filaments blocked at the barbed end with gelsolin. pyrene 11-17 gelsolin Homo sapiens 146-154 15034205-0 2004 Different global gene expression profiles in benzo[a]pyrene- and dioxin-treated vascular smooth muscle cells of AHR-knockout and wild-type mice. pyrene 53-59 aryl-hydrocarbon receptor Mus musculus 112-115 14659977-3 2004 In B6 mice, tanshinone IIA increased hepatic benzo(a)pyrene hydroxylation (AHH), 7-ethoxyresorufin O-deethylation, MROD, and 7-ethoxycoumarin O-deethylation activities. pyrene 53-59 ATPase, class II, type 9A Mus musculus 23-26 12946434-0 2003 The diesel exhaust component pyrene induces expression of IL-8 but not of eotaxin. pyrene 29-35 C-X-C motif chemokine ligand 8 Homo sapiens 58-62 14744740-8 2004 These data suggest that the UGT1A1 TATAA box polymorphism plays a role in an individual"s overall ability to detoxify benzo(a)pyrene and in cancer risk. pyrene 126-132 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 28-34 14645679-5 2003 Using Northern blots, we then confirmed that nickel can down-regulate both the basal and benzo[a]pyrene-inducible expression of AhR-dependent genes in mouse and human cell lines. pyrene 97-103 aryl-hydrocarbon receptor Mus musculus 128-131 14596602-6 2003 We then assessed the ability of these and wild-type myosin to bind strongly via two heads to an actin filament by measuring the fluorescence quenching of pyrene-labeled actin induced by myosin binding. pyrene 154-160 myosin heavy chain 14 Homo sapiens 52-58 14596602-6 2003 We then assessed the ability of these and wild-type myosin to bind strongly via two heads to an actin filament by measuring the fluorescence quenching of pyrene-labeled actin induced by myosin binding. pyrene 154-160 myosin heavy chain 14 Homo sapiens 186-192 12946434-3 2003 We have characterized the influence of pyrene, a polycyclic aromatic hydrocarbon (PAH) contained, for example, in diesel exhaust particles (DEP), on transcription and secretion of the chemokines interleukin-8 (IL-8) and eotaxin. pyrene 39-45 C-X-C motif chemokine ligand 8 Homo sapiens 195-208 12946434-3 2003 We have characterized the influence of pyrene, a polycyclic aromatic hydrocarbon (PAH) contained, for example, in diesel exhaust particles (DEP), on transcription and secretion of the chemokines interleukin-8 (IL-8) and eotaxin. pyrene 39-45 C-X-C motif chemokine ligand 8 Homo sapiens 210-214 12946434-3 2003 We have characterized the influence of pyrene, a polycyclic aromatic hydrocarbon (PAH) contained, for example, in diesel exhaust particles (DEP), on transcription and secretion of the chemokines interleukin-8 (IL-8) and eotaxin. pyrene 39-45 C-C motif chemokine ligand 11 Homo sapiens 220-227 12946434-6 2003 Promoter activity, mRNA production and protein expression of IL-8 were increased by pyrene. pyrene 84-90 C-X-C motif chemokine ligand 8 Homo sapiens 61-65 16256669-3 2003 Micropolarity studies using the I1/I3 ratio of the vibronic bands of pyrene and the behavior of the I(E)/I(M) ratio between the monomer and excimer emissions show the formation of hydrophobic domains. pyrene 69-75 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 32-37 16256674-4 2003 The I1/I3 ratio of pyrene in aqueous Pluronic P103 solutions at temperature below the CMT decreases with increases of NaCl concentration, which is related to the decrease of PPO solubility. pyrene 19-25 protoporphyrinogen oxidase Homo sapiens 174-177 12904039-1 2003 An alkylated hexa-peri-hexabenzocoronene with a covalently tethered pyrene unit serves as a model to study self-assembling discotic pi-system dyads both in the bulk and at a surface. pyrene 68-74 hexosaminidase subunit alpha Homo sapiens 13-17 16256674-4 2003 The I1/I3 ratio of pyrene in aqueous Pluronic P103 solutions at temperature below the CMT decreases with increases of NaCl concentration, which is related to the decrease of PPO solubility. pyrene 19-25 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 4-9 12851037-6 2003 In 3-methylcholanthrene-treated mouse liver microsomes, tanshinone IIA and two minor tanshinones, tanshinone I and cryptotanshinone, inhibited liver microsomal MROD activity without affecting EROD and benzo(a)pyrene hydroxylation activities at the concentrations up to 1 microM. pyrene 209-215 ATPase, class II, type 9A Mus musculus 67-70 14534614-2 2003 Lycopine in a concentration of 20 microM completely prevented the decrease in the rate of benz[a]pyrene hydroxylation and activation of p-nitrophenyl-UDP-glucuronosyl transferase caused by LPO induction in microsomes. pyrene 97-103 lactoperoxidase Rattus norvegicus 189-192 12926280-2 2003 7,8-Dihydro-BaP 1 gives a persistent bay-region benzyliclike carbocation which shows extensive charge delocalization into the pyrene moiety. pyrene 126-132 BRCA1 associated protein 1 Homo sapiens 12-17 12753412-0 2003 Benzo(a)pyrene-induced changes in p53 and related proteins in mouse skin. pyrene 8-14 transformation related protein 53, pseudogene Mus musculus 34-37 12432558-2 2002 A frequent MPO -463 G-->A polymorphism in the promoter region reduces MPO transcription and has been correlated with >4-fold lower benzo[a]pyrene-DNA adduct levels in the skin of coal tar-treated patients. pyrene 145-151 myeloperoxidase Homo sapiens 11-14 12624000-3 2003 Ellipticine, alpha-naphthoflavone (selective CYP1A1 inhibitors), and pyrene (selective CYP1B1 inhibitor), but not ketoconazole (selective CYP3A4 inhibitor) or furafylline (selective CYP1A2 inhibitor), abrogated the inhibitor effects of estradiol on cell activity, a profile consistent with a CYP1A1/CYP1B1-mediated mechanism. pyrene 69-75 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 87-93 12624000-3 2003 Ellipticine, alpha-naphthoflavone (selective CYP1A1 inhibitors), and pyrene (selective CYP1B1 inhibitor), but not ketoconazole (selective CYP3A4 inhibitor) or furafylline (selective CYP1A2 inhibitor), abrogated the inhibitor effects of estradiol on cell activity, a profile consistent with a CYP1A1/CYP1B1-mediated mechanism. pyrene 69-75 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 182-188 12624000-3 2003 Ellipticine, alpha-naphthoflavone (selective CYP1A1 inhibitors), and pyrene (selective CYP1B1 inhibitor), but not ketoconazole (selective CYP3A4 inhibitor) or furafylline (selective CYP1A2 inhibitor), abrogated the inhibitor effects of estradiol on cell activity, a profile consistent with a CYP1A1/CYP1B1-mediated mechanism. pyrene 69-75 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 292-298 12624000-3 2003 Ellipticine, alpha-naphthoflavone (selective CYP1A1 inhibitors), and pyrene (selective CYP1B1 inhibitor), but not ketoconazole (selective CYP3A4 inhibitor) or furafylline (selective CYP1A2 inhibitor), abrogated the inhibitor effects of estradiol on cell activity, a profile consistent with a CYP1A1/CYP1B1-mediated mechanism. pyrene 69-75 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 299-305 12742022-1 2003 To understand the mechanism of a functionally important ATP-induced allosteric transition of GroEL, we have studied the effect of a series of metal fluoride-ADP complexes and vanadate-ADP on GroEL by kinetic fluorescence measurement of pyrene-labeled GroEL and by small-angle X-ray scattering measurement of wild-type GroEL. pyrene 236-242 heat shock protein family D (Hsp60) member 1 Homo sapiens 93-98 12628579-3 2003 CYP1A1 mRNA was detected in control mice at very low levels in liver, lung, heart, kidney, intestine, thymus, testis, uterus, ovary, and brain and was highly induced in these organs by benzo[a]pyrene and 3,4,3",4"-tetrachlorobiphenyl in AhR(+/+) mice. pyrene 193-199 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-6 12432558-2 2002 A frequent MPO -463 G-->A polymorphism in the promoter region reduces MPO transcription and has been correlated with >4-fold lower benzo[a]pyrene-DNA adduct levels in the skin of coal tar-treated patients. pyrene 145-151 myeloperoxidase Homo sapiens 73-76 12619281-5 2002 On the contrary, degradation pattern of BaP was not obviously improved by the preexposure to anthracene or pyrene, and was even inhibited by benz(a) anthracene. pyrene 107-113 prohibitin 2 Homo sapiens 40-43 12441364-3 2002 In this study, several other PAHs, including fluorene, fluoranthene, pyrene, chrysene, phenanthrene and anthracene, were found to act as very weak inducers of ER-mediated activity in the MCF-7 cell line stably transfected with a luciferase reporter gene. pyrene 69-75 estrogen receptor 1 Homo sapiens 159-161 12414705-6 2002 A Ca(2+)-independent conformational change in that region was detected upon troponin binding to actin-Tm via an increase in the fluorescence of a pyrene probe attached to another yeast actin mutant that we used (Cys(1)). pyrene 146-152 actin Saccharomyces cerevisiae S288C 96-101 12414705-6 2002 A Ca(2+)-independent conformational change in that region was detected upon troponin binding to actin-Tm via an increase in the fluorescence of a pyrene probe attached to another yeast actin mutant that we used (Cys(1)). pyrene 146-152 actin Saccharomyces cerevisiae S288C 185-190 12234191-9 2002 FRET analysis also suggests that ST2-GFP binds tightly to pyrene-labeled GM3 but not to ST1. pyrene 58-64 interleukin 1 receptor-like 1 Mus musculus 33-36 12419261-7 2002 Binding of cofilin enhanced excimer formation between pyrene probes attached to Cys41 and Cys374 on Q41C F-actin. pyrene 54-60 cofilin Saccharomyces cerevisiae S288C 11-18 12358527-8 2002 In lipid-free aqueous/glycerol solutions of CYP3A4, addition of pyrene affords a concentration-dependent low-spin to high-spin conversion of the CYP3A4 heme prosthetic group, indicating occupancy of the active site by pyrene. pyrene 64-70 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 44-50 12358527-8 2002 In lipid-free aqueous/glycerol solutions of CYP3A4, addition of pyrene affords a concentration-dependent low-spin to high-spin conversion of the CYP3A4 heme prosthetic group, indicating occupancy of the active site by pyrene. pyrene 64-70 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 145-151 12358527-8 2002 In lipid-free aqueous/glycerol solutions of CYP3A4, addition of pyrene affords a concentration-dependent low-spin to high-spin conversion of the CYP3A4 heme prosthetic group, indicating occupancy of the active site by pyrene. pyrene 218-224 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 145-151 12358527-9 2002 Under the same conditions, in the presence of CYP3A4 but not other heme proteins, the excimer/monomer ratio (E/M) of pyrene was decreased in emission spectra, compared to pyrene alone. pyrene 117-123 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 46-52 12358527-9 2002 Under the same conditions, in the presence of CYP3A4 but not other heme proteins, the excimer/monomer ratio (E/M) of pyrene was decreased in emission spectra, compared to pyrene alone. pyrene 171-177 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 46-52 12358527-12 2002 Together, the results demonstrate that pyrene.pyrene ground-state complexes occupy the CYP3A4 active site, and they provide the first spectroscopic evidence for substrate complexes within a single fluid active site. pyrene 39-45 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 87-93 12358527-12 2002 Together, the results demonstrate that pyrene.pyrene ground-state complexes occupy the CYP3A4 active site, and they provide the first spectroscopic evidence for substrate complexes within a single fluid active site. pyrene 46-52 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 87-93 12358527-0 2002 Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site. pyrene 0-6 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 46-65 12358527-0 2002 Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site. pyrene 7-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 46-65 12358527-5 2002 CYP3A4 hydroxylates pyrene with positive cooperativity. pyrene 20-26 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 12234191-9 2002 FRET analysis also suggests that ST2-GFP binds tightly to pyrene-labeled GM3 but not to ST1. pyrene 58-64 granulocyte macrophage antigen 3 Mus musculus 73-76 12151310-0 2002 Lung-specific expression of dominant-negative mutant p53 in transgenic mice increases spontaneous and benzo(a)pyrene-induced lung cancer. pyrene 110-116 transformation related protein 53, pseudogene Mus musculus 53-56 12665301-6 2002 I1/I3 intensity ratios from vibrational bands in the fluorescence spectra and the fluorescence decay rates of attached 1-alkylpyrenyl groups are much less sensitive to changes in the copolymer composition than are those of pyrene. pyrene 223-229 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 0-5 12220190-6 2002 Here we employ the pyrene rescue method in combination with transient kinetic approaches to assess the functional roles of six conserved enzymatic groups of UDG that have been implicated in the "pinch, push, plug, and pull" base-flipping mechanism (see the preceding paper in this issue). pyrene 19-25 uracil DNA glycosylase Homo sapiens 157-160 12220190-10 2002 Preorganization of uracil in an extrahelical conformation by pyrene allows diffusion-controlled damage recognition by all of these base-flipping mutants, and allows the UDG conformational change to proceed as rapidly as the rate of uracil flipping with the natural U/A base pair. pyrene 61-67 uracil DNA glycosylase Homo sapiens 169-172 12220190-11 2002 Thus, the pyrene wedge substrate allows UDG to recognize uracil by a lock-and-key mechanism, rather than the natural induced-fit mechanism. pyrene 10-16 uracil DNA glycosylase Homo sapiens 40-43 12117779-7 2002 We also found that 6-aminochrysene, chrysene, benzo[e]pyrene, and 1-nitropyrene weakly induced the mRNA expression of CYP1A1 and 1B1, whereas anthracene, pyrene, and fluoranthene that have been reported to be non-carcinogenic in rodents, were very low or inactive in inducing these P450s. pyrene 54-60 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 118-132 12123662-1 2002 An assay using fluorogenic peptides based on the monomer/excimer fluorescence features of pyrene was developed to measure the proteolytic activity of trypsin, a serine protease. pyrene 90-96 coagulation factor II, thrombin Homo sapiens 161-176 12023237-5 2002 Saturation binding of cofilin prevents pyrene fluorescence enhancement normally associated with actin polymerization. pyrene 39-45 cofilin 1 Homo sapiens 22-29 12107646-8 2002 Pyrene, 1-nitropyrene, 1-aminopyrene, 1,3-, 1,6-, and 1,8-dinitropyrenes slightly induced CYP1 mRNAs, but 1,3-dinitropyrene produced a 6-fold induction of CYP1A1 mRNA in MCF-7 cells. pyrene 0-6 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 90-94 12107646-8 2002 Pyrene, 1-nitropyrene, 1-aminopyrene, 1,3-, 1,6-, and 1,8-dinitropyrenes slightly induced CYP1 mRNAs, but 1,3-dinitropyrene produced a 6-fold induction of CYP1A1 mRNA in MCF-7 cells. pyrene 0-6 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 155-161 11959868-3 2002 Pyrene at each of these positions produced differing fluorescence spectra in G-actin. pyrene 0-6 actin Saccharomyces cerevisiae S288C 79-84 11959868-8 2002 F-actin quenching was biphasic for the 265, 266, and 269 but not 267 probes, suggesting that in F-actin, the pyrene samples multiple environments. pyrene 109-115 actin Saccharomyces cerevisiae S288C 2-7 11959868-8 2002 F-actin quenching was biphasic for the 265, 266, and 269 but not 267 probes, suggesting that in F-actin, the pyrene samples multiple environments. pyrene 109-115 actin Saccharomyces cerevisiae S288C 98-103 11959868-9 2002 Finally, in F-actin the probe at 266 interacts with one at Cys(374) on a monomer in the opposing strand, producing a pyrene excimer band. pyrene 117-123 actin Saccharomyces cerevisiae S288C 14-19 12036877-5 2002 Intact and Fab fragments of alpha Arp2 inhibited TRAP-stimulated actin-polymerizing activity in platelet extracts as measured by the pyrene assay. pyrene 133-139 FA complementation group B Homo sapiens 11-14 12036877-5 2002 Intact and Fab fragments of alpha Arp2 inhibited TRAP-stimulated actin-polymerizing activity in platelet extracts as measured by the pyrene assay. pyrene 133-139 actin related protein 2 Homo sapiens 34-38 12036877-5 2002 Intact and Fab fragments of alpha Arp2 inhibited TRAP-stimulated actin-polymerizing activity in platelet extracts as measured by the pyrene assay. pyrene 133-139 TRAP Homo sapiens 49-53 12054549-3 2002 Four monoclonal and two polyclonal anti-p53 antibodies, four of them from two different sources, were compared for their ability to detect in immunoblotting the benzo(a)pyrene-induced p53 from C57BL/6 mouse skin and MCF-7 human breast carcinoma cells. pyrene 169-175 transformation related protein 53, pseudogene Mus musculus 40-43 11994790-0 2002 Effect of pyrene on hepatic cytochrome P450 1A (CYP1A) expression in Nile Tilapia (Oreochromis niloticus). pyrene 10-16 cytochrome P450 1A Oreochromis niloticus 28-46 11994790-0 2002 Effect of pyrene on hepatic cytochrome P450 1A (CYP1A) expression in Nile Tilapia (Oreochromis niloticus). pyrene 10-16 cytochrome P450 1A Oreochromis niloticus 48-53 11994790-1 2002 The effect of pyrene on the regulation of the gene expression of cytochrome P4501A ( CYP1A) was studied in tilapia (Oreochromis niloticus), a tropical fish of great ecological and economical importance. pyrene 14-20 cytochrome P450 1A Oreochromis niloticus 65-82 11994790-1 2002 The effect of pyrene on the regulation of the gene expression of cytochrome P4501A ( CYP1A) was studied in tilapia (Oreochromis niloticus), a tropical fish of great ecological and economical importance. pyrene 14-20 cytochrome P450 1A Oreochromis niloticus 85-90 11994790-4 2002 Hepatic CYP1A mRNA levels showed a significant increase at day 1 after pyrene injection (20 mg kg(-1) body weight [BW]), and this CYP1A mRNA levels did not return to basal levels for up to 5 days. pyrene 71-77 cytochrome P450 1A Oreochromis niloticus 8-13 11994790-5 2002 The immunoblot analysis of CYP1A protein levels using polyclonal rabbit-anti-trout antibodies in the liver of pyrene-treated (20 mg kg(-1) BW) tilapias showed a 1.9-fold increase at day 3 after injection. pyrene 110-116 cytochrome P450 1A Oreochromis niloticus 27-32 11994790-7 2002 CYP1A protein and EROD activity remained increased for 5 days after a single pyrene IP administration. pyrene 77-83 cytochrome P450 1A Oreochromis niloticus 0-5 12054549-3 2002 Four monoclonal and two polyclonal anti-p53 antibodies, four of them from two different sources, were compared for their ability to detect in immunoblotting the benzo(a)pyrene-induced p53 from C57BL/6 mouse skin and MCF-7 human breast carcinoma cells. pyrene 169-175 transformation related protein 53, pseudogene Mus musculus 184-187 11902669-2 2002 Fluorescent probes in addition to bis-ANS, like cis-parinaric acid (PA) and pyrene, show higher quantum yields or Ham ratios when bound to alphaA-crystallin than to alphaB-crystallin at room temperature. pyrene 76-82 crystallin alpha B Bos taurus 165-182 12077976-1 2002 The researchers of the Republican Cancer Research Center of the Ministry of Health of the Republic of Uzbekistan have been monitoring the levels of the carcinogenic agent benz(a)pyrene (B(a)P) in the emissions by thermoelectric plants. pyrene 178-184 prohibitin 2 Homo sapiens 186-191 11748233-2 2002 Using a helix-loop-helix construct consisting of the adjacent transmembrane segments 3 and 4 of the cystic fibrosis transmembrane conductance regulator (CFTR) labeled with pyrene at both N and C termini, we describe a system for the study of intramolecular helix-helix interactions within a polytopic membrane protein. pyrene 172-178 CF transmembrane conductance regulator Homo sapiens 100-151 11748233-2 2002 Using a helix-loop-helix construct consisting of the adjacent transmembrane segments 3 and 4 of the cystic fibrosis transmembrane conductance regulator (CFTR) labeled with pyrene at both N and C termini, we describe a system for the study of intramolecular helix-helix interactions within a polytopic membrane protein. pyrene 172-178 CF transmembrane conductance regulator Homo sapiens 153-157 11808735-1 2002 [70]fullerene has been shown to form 1:1 EDA complex with anthracene, naphthalene, phenanthrene, pyrene and acenaphthene in CCl4 medium. pyrene 97-103 ectodysplasin A Homo sapiens 41-44 11944680-2 2002 By utilizing an infrared spectromicroscope and a very bright, nondestructive synchrotron photon source, we monitored in situ and, over time, the influence of HA on the progression of degradation of pyrene (a model PAH) by a bacterial colony on a magnetite surface. pyrene 198-204 phenylalanine hydroxylase Homo sapiens 214-217 11944680-3 2002 Our results indicate that HA dramatically shortens the onset time for PAH biodegradation from 168 to 2 h. In the absence of HA, it takes the bacteria about 168 h to produce sufficient glycolipids to solubilize pyrene and make it bioavailable for biodegradation. pyrene 210-216 phenylalanine hydroxylase Homo sapiens 70-73 11323399-13 2001 In occupationally exposed populations CYP2E1 and GSTM1 appear to play an important role in the metabolism of pyrene and naphthalene. pyrene 109-115 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 38-44 11517216-6 2001 Tight binding between myosin-Va and pyrene-labeled F-actin in the presence of ATP and Ca(2+) was also detected by quenching of the pyrene fluorescence. pyrene 36-42 myosin VA Homo sapiens 22-31 11517216-6 2001 Tight binding between myosin-Va and pyrene-labeled F-actin in the presence of ATP and Ca(2+) was also detected by quenching of the pyrene fluorescence. pyrene 131-137 myosin VA Homo sapiens 22-31 11549037-1 2001 The addition of composted PAH-contaminated soil to PAH-contaminated soil spiked with 14C-labeled pyrene resulted in rapid mineralization of pyrene (more than 57% after 21 days compared with 3.4% in un-amended soil). pyrene 97-103 phenylalanine hydroxylase Homo sapiens 26-29 11549037-1 2001 The addition of composted PAH-contaminated soil to PAH-contaminated soil spiked with 14C-labeled pyrene resulted in rapid mineralization of pyrene (more than 57% after 21 days compared with 3.4% in un-amended soil). pyrene 97-103 phenylalanine hydroxylase Homo sapiens 51-54 11549037-1 2001 The addition of composted PAH-contaminated soil to PAH-contaminated soil spiked with 14C-labeled pyrene resulted in rapid mineralization of pyrene (more than 57% after 21 days compared with 3.4% in un-amended soil). pyrene 140-146 phenylalanine hydroxylase Homo sapiens 26-29 11549037-1 2001 The addition of composted PAH-contaminated soil to PAH-contaminated soil spiked with 14C-labeled pyrene resulted in rapid mineralization of pyrene (more than 57% after 21 days compared with 3.4% in un-amended soil). pyrene 140-146 phenylalanine hydroxylase Homo sapiens 51-54 11454727-1 2001 Human UDP-glucuronosyltransferases (UGT, EC 2.4.1.17) involved in the biotransformation of pyrene were investigated by a sensitive fluorometric high-performance liquid chromatography (HPLC)method developed for determining activities toward 1-hydroxypyrene. pyrene 91-97 beta-1,3-glucuronyltransferase 2 Homo sapiens 6-34 11454727-1 2001 Human UDP-glucuronosyltransferases (UGT, EC 2.4.1.17) involved in the biotransformation of pyrene were investigated by a sensitive fluorometric high-performance liquid chromatography (HPLC)method developed for determining activities toward 1-hydroxypyrene. pyrene 91-97 beta-1,3-glucuronyltransferase 2 Homo sapiens 36-39 11481389-2 2001 We have used NQO1(-/-) C57BL/6 mice to show that NQO1 protects them from skin cancer induced by the polycyclic aromatic hydrocarbon benzo[a]pyrene. pyrene 140-146 NAD(P)H dehydrogenase, quinone 1 Mus musculus 49-53 11323399-13 2001 In occupationally exposed populations CYP2E1 and GSTM1 appear to play an important role in the metabolism of pyrene and naphthalene. pyrene 109-115 glutathione S-transferase mu 1 Homo sapiens 49-54 11413553-5 2001 Treatment with ADP and GPIIb/IIIa receptor antagonists reduced PTCA induced changes in pyrene dimer formation. pyrene 87-93 integrin subunit alpha 2b Homo sapiens 23-28 11267876-3 2001 In this study, we demonstrate that cortactin activates Arp2/3 complex based on direct visualization of filament networks and pyrene actin assays. pyrene 125-131 cortactin Homo sapiens 35-44 11267876-3 2001 In this study, we demonstrate that cortactin activates Arp2/3 complex based on direct visualization of filament networks and pyrene actin assays. pyrene 125-131 actin related protein 2 Homo sapiens 55-59 11158716-0 2001 Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor-mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo. pyrene 21-27 estrogen receptor 1 Homo sapiens 69-86 11342042-6 2001 Furthermore, the fluorescence changes of pyrene-labeled GroEL indicated that GroEL has two kinds of nucleotide binding sites. pyrene 41-47 heat shock protein family D (Hsp60) member 1 Homo sapiens 56-61 11342042-6 2001 Furthermore, the fluorescence changes of pyrene-labeled GroEL indicated that GroEL has two kinds of nucleotide binding sites. pyrene 41-47 heat shock protein family D (Hsp60) member 1 Homo sapiens 77-82 11716141-6 2001 By contrast, effects of A beta on the mobility of pyrene were not reduced for aged synaptic membranes, but even seemed to be enhanced in the case of aged mitochondrial membranes. pyrene 50-56 amyloid beta (A4) precursor protein Mus musculus 24-30 11413553-6 2001 An unexpected decrease in pyrene dimer formation (P0.05) was detected when the GPIIb/IIIa receptor antagonist was given together with an ADP receptor antagonist. pyrene 26-32 integrin subunit alpha 2b Homo sapiens 79-84 11710120-6 2000 The decreasing polarity of the microenvironment of pyrene solubilized into mucin solutions at temperatures above 30 degrees C, concomitant with the gel-sol transition, shows the hydrophobicity of the formed aggregates. pyrene 51-57 LOC100508689 Homo sapiens 75-80 11085502-8 2000 These results demonstrate that NQO1 acts as an endogenous factor in protection against benzo(a)pyrene carcinogenicity. pyrene 95-101 NAD(P)H dehydrogenase, quinone 1 Mus musculus 31-35 10956644-2 2000 We observed that the supernatants obtained from suspensions of thrombin-activated platelets stimulated the exchange of pyrene (py)-labeled sphingomyelin between lipid vesicles in vitro. pyrene 119-130 coagulation factor II, thrombin Homo sapiens 63-71 10764626-0 2000 Low-level doxorubicin resistance in benzo[a]pyrene-treated KB-3-1 cells is associated with increased LRP expression and altered subcellular drug distribution. pyrene 44-50 major vault protein Homo sapiens 101-104 10997940-4 2000 Moreover, when the reaction kinetics of the oxidation of pyrene by CYP3A4 was examined in the absence of MgCl(2), it was found that the substrate-velocity curve was best approximated by a sigmoidal velocity curve (Hill coefficient 1.7 +/- 0.1). pyrene 57-63 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 67-73 11040375-5 2000 Pyrene labeled phosphatidylcholine was added to 50 microg of cytosolic protein in Tris buffer (pH 8.0) containing fatty acid free-bovine serum albumin for a final assay volume of 2 ml. pyrene 0-6 albumin Mus musculus 137-150 10825386-8 2000 Furthermore, we observed that the activity of CYP1A1 resulting either from the stimulation of the endogenous gene by benzo[a]pyrene treatment or from the transfection of an expression vector, repressed the activity of the CYP2E1 gene promoter. pyrene 125-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 46-52 10825386-8 2000 Furthermore, we observed that the activity of CYP1A1 resulting either from the stimulation of the endogenous gene by benzo[a]pyrene treatment or from the transfection of an expression vector, repressed the activity of the CYP2E1 gene promoter. pyrene 125-131 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 222-228 10756232-0 2000 The environmental pollutant pyrene induces the production of IL-4. pyrene 28-34 interleukin 4 Homo sapiens 61-65 10756232-2 2000 OBJECTIVE: Because IL-4 organizes allergic responses in vivo, we have investigated whether pyrene, a major compound of diesel exhaust particles, can affect the production of IL-4. pyrene 91-97 interleukin 4 Homo sapiens 174-178 10756232-5 2000 RESULTS: Pyrene induced transcription of IL-4 messenger RNA and expression of IL-4 protein in primary human T cells. pyrene 9-15 interleukin 4 Homo sapiens 41-45 10756232-5 2000 RESULTS: Pyrene induced transcription of IL-4 messenger RNA and expression of IL-4 protein in primary human T cells. pyrene 9-15 interleukin 4 Homo sapiens 78-82 10756232-6 2000 Pyrene, but not related polyaromatic hydrocarbons, enhanced basal transcription of the human and mouse IL-4 promoter. pyrene 0-6 interleukin 4 Mus musculus 103-107 10756232-7 2000 CONCLUSION: Our results suggest that pyrene may promote allergic diseases by inducing the production of IL-4. pyrene 37-43 interleukin 4 Homo sapiens 104-108 20865137-5 2000 At 5 muM DNA concentration, T(m) values range from 41.7 C (core sequence) to 64.1 C (with dangling pyrene residues). pyrene 101-107 latexin Homo sapiens 5-8 10677229-9 2000 This demonstrates a transition at the S1 contact with actin"s N-terminus between the weakly and strongly bound states, and implies either a closer proximity of the pyrene probe on Cys-1 to structural elements on S1 (most likely the loop of residues 626-647) or greater S1-induced changes at the N-terminus of actin in the weakly bound acto-S1 states. pyrene 164-170 actin Saccharomyces cerevisiae S288C 54-59 10753208-0 2000 LacI mutation spectra following benzo[a]pyrene treatment of Big Blue mice. pyrene 40-46 tissue factor pathway inhibitor Mus musculus 0-4 20016809-4 1999 The fluorophores conjugated to deoxyribose at C(1) in the alpha-d-form include terphenyl, stilbene, terthiophene, benzoterthiophene, and pyrene. pyrene 137-143 heterogeneous nuclear ribonucleoprotein C Homo sapiens 46-50 10631125-0 2000 Differential protection by rat UDP-glucuronosyltransferase 1A7 against Benzo[a]pyrene-3,6-quinone- versus Benzo[a]pyrene-induced cytotoxic effects in human lymphoblastoid cells. pyrene 79-85 UDP glucuronosyltransferase 1 family, polypeptide A7C Rattus norvegicus 31-62 10631125-1 2000 UDP-glucuronosyltransferase 1A7 (UGT1A7) is a polyaromatic hydrocarbon (PAH)-inducible UGT with activity toward various benzo[a]pyrene (B[a]P) metabolites. pyrene 128-134 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 0-31 10631125-1 2000 UDP-glucuronosyltransferase 1A7 (UGT1A7) is a polyaromatic hydrocarbon (PAH)-inducible UGT with activity toward various benzo[a]pyrene (B[a]P) metabolites. pyrene 128-134 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 33-39 10631125-1 2000 UDP-glucuronosyltransferase 1A7 (UGT1A7) is a polyaromatic hydrocarbon (PAH)-inducible UGT with activity toward various benzo[a]pyrene (B[a]P) metabolites. pyrene 128-134 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 33-36 10730576-1 1999 The dynamics of the interaction of fast skeletal muscle myosin subfragment-1 with pyrene-labelled actin were examined using both stopped-flow and pressure relaxation methods. pyrene 82-88 myosin heavy chain 14 Homo sapiens 56-62 10548541-9 1999 Recombinant ERK was found to co-sediment with purified actin and induced a fluorescence change in pyrene-labelled F-actin (K(a)=5x10(6) M(-1)). pyrene 98-104 mitogen-activated protein kinase 1 Homo sapiens 12-15 10462050-5 1999 Western blot analysis using the Ab1, anti-P-gp polyclonal antibodies indicates the presence of two bands of 66 and 96 kDa of which the intensity increased with time in benzo(a)pyrene-treated ciliates. pyrene 176-182 phosphoglycolate phosphatase Homo sapiens 42-46 10395759-4 1999 We observed significant solubilization of pyrene in F127 solutions below the cmt, which was also reflected in the measured I1/I3 ratios. pyrene 42-48 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 123-128 10344744-1 1999 The pi class glutathione S-transferase (GSTP1-1), which is polymorphic in human populations, is believed to play an important role in detoxification of the ultimate carcinogen of widespread environmental pollutant benzo[a]pyrene [(+)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide [(+)-anti-BPDE]]. pyrene 222-228 glutathione S-transferase kappa 1 Homo sapiens 13-38 10429191-2 1999 Gelsolin increased the fluorescence of 7-nitrobenz-2-oxa-1,3-diazole (NBD)- or pyrene-labeled PtdIns-(4,5)-P2 and NBD-PtdIns-(3,4,5)-P3. pyrene 79-85 gelsolin Homo sapiens 0-8 10429191-8 1999 Fluorescence energy transfer from gelsolin to pyrene-PtdIns-(4,5)-P2 was much stronger with intact gelsolin than the N-terminal region of gelsolin containing the PtdIns-(4,5)-P2 binding sites, suggesting that PtdIns-(4,5)-P2 may bind near a site formed by the juxtaposition of the N- and C-terminal domains of gelsolin. pyrene 46-52 gelsolin Homo sapiens 34-42 10429191-8 1999 Fluorescence energy transfer from gelsolin to pyrene-PtdIns-(4,5)-P2 was much stronger with intact gelsolin than the N-terminal region of gelsolin containing the PtdIns-(4,5)-P2 binding sites, suggesting that PtdIns-(4,5)-P2 may bind near a site formed by the juxtaposition of the N- and C-terminal domains of gelsolin. pyrene 46-52 gelsolin Homo sapiens 99-107 10429191-8 1999 Fluorescence energy transfer from gelsolin to pyrene-PtdIns-(4,5)-P2 was much stronger with intact gelsolin than the N-terminal region of gelsolin containing the PtdIns-(4,5)-P2 binding sites, suggesting that PtdIns-(4,5)-P2 may bind near a site formed by the juxtaposition of the N- and C-terminal domains of gelsolin. pyrene 46-52 gelsolin Homo sapiens 99-107 10429191-8 1999 Fluorescence energy transfer from gelsolin to pyrene-PtdIns-(4,5)-P2 was much stronger with intact gelsolin than the N-terminal region of gelsolin containing the PtdIns-(4,5)-P2 binding sites, suggesting that PtdIns-(4,5)-P2 may bind near a site formed by the juxtaposition of the N- and C-terminal domains of gelsolin. pyrene 46-52 gelsolin Homo sapiens 99-107 10344744-1 1999 The pi class glutathione S-transferase (GSTP1-1), which is polymorphic in human populations, is believed to play an important role in detoxification of the ultimate carcinogen of widespread environmental pollutant benzo[a]pyrene [(+)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide [(+)-anti-BPDE]]. pyrene 222-228 glutathione S-transferase pi 1 Homo sapiens 40-47 10217427-3 1999 A base-substituted analog of TTP containing a pyrene group (PyrdUTP) was synthesized and used as an active site-bound photosensitizer for photoaffinity modification of DNA polymerase beta (pol beta). pyrene 46-52 SH3 domain binding protein 4 Homo sapiens 29-32 10207025-3 1999 A pyrene-peptide conjugate was complexed with gp96 under a variety of conditions. pyrene 2-8 heat shock protein 90 beta family member 1 Homo sapiens 46-50 10207025-4 1999 At room temperature in low salt (20 mM NaCl), the peptide binds gp96 with a strong affinity (approximately 100-150 nM) and forms pyrene excimers, suggesting that the peptides were assembled as dimers. pyrene 129-135 heat shock protein 90 beta family member 1 Homo sapiens 64-68 10207025-9 1999 Resonance energy transfer between the intrinsic tryptophan(s) in gp96 and pyrene suggested that one or more tryptophan residues were within the critical Forster distance of 27-30 A from the pyrene in the bound peptide. pyrene 190-196 heat shock protein 90 beta family member 1 Homo sapiens 65-69 10227173-4 1999 Inoculation of these two soils with DC1 and PD2 (bacteria capable of accelerating the phenanthrene and pyrene mineralisation in soil in the absence of crude oil) either at day 0 or after release as 14CO2 by indigenous degraders had ceased, failed to increase or initiate further mineralisation. pyrene 103-109 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 44-47 10085244-4 1999 As shown by time-resolved fluorescence measurements, translocation of Pyr-C12 from the Pyr-C12-beta-cyclodextrin complex to nsL-TP changed dramatically the direct molecular environment of the pyrene moiety: i.e. the fluorescence lifetime of the directly excited pyrene increased at least by 25% and a distinct rotational correlation time of 7 ns was observed. pyrene 192-198 sterol carrier protein 2 Bos taurus 124-130 10085244-4 1999 As shown by time-resolved fluorescence measurements, translocation of Pyr-C12 from the Pyr-C12-beta-cyclodextrin complex to nsL-TP changed dramatically the direct molecular environment of the pyrene moiety: i.e. the fluorescence lifetime of the directly excited pyrene increased at least by 25% and a distinct rotational correlation time of 7 ns was observed. pyrene 262-268 sterol carrier protein 2 Bos taurus 124-130 10217427-5 1999 The pyrene sensitizer (PyrdUTP), excited by light (365-450 nm), can activate the photoreagent, cross-linking it to pol beta as a result of fluorescence resonance energy transfer. pyrene 4-10 DNA polymerase beta Homo sapiens 115-123 10217427-3 1999 A base-substituted analog of TTP containing a pyrene group (PyrdUTP) was synthesized and used as an active site-bound photosensitizer for photoaffinity modification of DNA polymerase beta (pol beta). pyrene 46-52 DNA polymerase beta Homo sapiens 168-187 10217427-3 1999 A base-substituted analog of TTP containing a pyrene group (PyrdUTP) was synthesized and used as an active site-bound photosensitizer for photoaffinity modification of DNA polymerase beta (pol beta). pyrene 46-52 DNA polymerase beta Homo sapiens 189-197 10329214-11 1999 Fluorescence experiments using pyrene-labeled Tm demonstrated that the binding of cTnT77-289 to Tm was 3-4 fold stronger than that of cTnT. pyrene 31-37 troponin T2, cardiac type Rattus norvegicus 82-92 9858662-0 1998 Effects of carbaryl and naphthalene on rat hepatic CYP1A1/2: potential binding to Ah receptor and 4S benzo(a)pyrene-binding protein. pyrene 109-115 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 51-57 9826629-2 1998 In this study we have measured the binding of the amino-terminal half of gelsolin, G1-3, to pyrene-labeled F-actin as a function of Ca2+ concentration. pyrene 92-98 gelsolin Homo sapiens 73-81 9826629-2 1998 In this study we have measured the binding of the amino-terminal half of gelsolin, G1-3, to pyrene-labeled F-actin as a function of Ca2+ concentration. pyrene 92-98 activating transcription factor 6 beta Homo sapiens 83-87 9826629-5 1998 Titrations of pyrene-F-actin with G1-3 and gelsolin show that the quenching of pyrene fluorescence is identical in extent and stoichiometry for both G1-3 and gelsolin. pyrene 14-20 activating transcription factor 6 beta Homo sapiens 34-38 9826629-5 1998 Titrations of pyrene-F-actin with G1-3 and gelsolin show that the quenching of pyrene fluorescence is identical in extent and stoichiometry for both G1-3 and gelsolin. pyrene 14-20 gelsolin Homo sapiens 43-51 10329214-11 1999 Fluorescence experiments using pyrene-labeled Tm demonstrated that the binding of cTnT77-289 to Tm was 3-4 fold stronger than that of cTnT. pyrene 31-37 troponin T2, cardiac type Rattus norvegicus 82-86 10529736-0 1999 Effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA mice. pyrene 46-52 transformation related protein 53, pseudogene Mus musculus 31-34 10529736-0 1999 Effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA mice. pyrene 46-52 xeroderma pigmentosum, complementation group A Mus musculus 106-109 10578486-0 1999 Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by baicalein. pyrene 92-98 CD1 antigen complex Mus musculus 109-113 9748534-0 1998 A comparative study of in vivo mutation assays: analysis of hprt, lacI, cII/cI and as mutational targets for N-nitroso-N-methylurea and benzo[a]pyrene in Big Blue mice. pyrene 144-150 hypoxanthine guanine phosphoribosyl transferase Mus musculus 60-64 9833994-5 1998 RESULTS: The pyrene fluorescence molecule were successfully conjugated at the amino group of the end of PBLA chain by GPC with three different detectors. pyrene 13-19 glycophorin C (Gerbich blood group) Homo sapiens 118-121 9826191-3 1998 A fluorescent analogue of 12 carbons with a pyrene moiety attached at the end, alone or in conjunction with an anthroyloxy analogue, indicated that LTP could bind two fatty acids although with a marked difference in affinity. pyrene 44-50 lipid transfer protein Zea mays 148-151 9801792-5 1998 The effect of p85 alpha/profilin complex on polymerization of actin monomers was monitored fluorimetrically employing pyrene-labelled actin monomers. pyrene 118-124 phosphoinositide-3-kinase regulatory subunit 1 Homo sapiens 14-23 9765516-8 1998 This was accomplished by monitoring resonance energy transfer from a pyrene-labeled phospholipid to the heme of cyt c. pyrene 69-75 cytochrome c, somatic Homo sapiens 112-117 9609692-6 1998 However, the trend in dGamma/dpi appears to originate from characteristics of the monolayer and not from those of the protein, since a much different adsorbate (i.e., a positively charged pyrene derivative) exhibited a similar trend in dGamma/dpi with monolayer composition. pyrene 188-194 Adaptor Protein complex 1, gamma subunit Drosophila melanogaster 236-242 9789950-3 1998 Immunohistochemical assessment of altered p53 expression on liver sections with polyclonal serum (CM5) resulted in positive staining in 17/21 benzo(a)pyrene-, 1/18 thioacetamide-, 2/21 clofibric acid-, 2/21 phenobarbitone-, 7/19 ethinylestradiol-, 1/21 tryptophan-, 3/19 thyroxine-, and 1/21 fructose-treated rats and in 2/19 controls. pyrene 150-156 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 42-45 9698363-5 1998 The titration of pyrene-labeled rabbit skeletal actin with human profilin yielded a Kd of 2.8 microM, similar to the Kd of 2.0 microM for the interaction between yeast profilin and pyrene-labeled yeast actin. pyrene 17-23 profilin Saccharomyces cerevisiae S288C 65-73 9698363-5 1998 The titration of pyrene-labeled rabbit skeletal actin with human profilin yielded a Kd of 2.8 microM, similar to the Kd of 2.0 microM for the interaction between yeast profilin and pyrene-labeled yeast actin. pyrene 17-23 profilin Saccharomyces cerevisiae S288C 168-176 9698363-5 1998 The titration of pyrene-labeled rabbit skeletal actin with human profilin yielded a Kd of 2.8 microM, similar to the Kd of 2.0 microM for the interaction between yeast profilin and pyrene-labeled yeast actin. pyrene 181-187 profilin Saccharomyces cerevisiae S288C 65-73 9698363-5 1998 The titration of pyrene-labeled rabbit skeletal actin with human profilin yielded a Kd of 2.8 microM, similar to the Kd of 2.0 microM for the interaction between yeast profilin and pyrene-labeled yeast actin. pyrene 181-187 profilin Saccharomyces cerevisiae S288C 168-176 9661901-0 1998 Elevated frequencies of benzo(a)pyrene-induced Hprt mutations in internal tissue of XPA-deficient mice. pyrene 32-38 hypoxanthine guanine phosphoribosyl transferase Mus musculus 47-51 9661901-0 1998 Elevated frequencies of benzo(a)pyrene-induced Hprt mutations in internal tissue of XPA-deficient mice. pyrene 32-38 xeroderma pigmentosum, complementation group A Mus musculus 84-87 9644269-1 1998 The rate of the non-directional transfer of cholesteryl ester and triglyceride by human cholesteryl ester transfer protein (CETP) was measured between human plasma lipoproteins by monitoring fluorescence spectrum of pyrene-labeled lipid. pyrene 216-222 cholesteryl ester transfer protein Homo sapiens 88-122 9644269-1 1998 The rate of the non-directional transfer of cholesteryl ester and triglyceride by human cholesteryl ester transfer protein (CETP) was measured between human plasma lipoproteins by monitoring fluorescence spectrum of pyrene-labeled lipid. pyrene 216-222 cholesteryl ester transfer protein Homo sapiens 124-128 9724516-8 1998 Studies on the influence of quinacrine on the activity of PLA2 toward pyrene-labeled phospholipid analogues revealed that the hydrolysis of phosphatidylcholine was progressively reduced as a function of increasing [quinacrine]. pyrene 70-76 phospholipase A2 group IB Homo sapiens 58-62 9555005-7 1998 PLTP-mediated phospholipid transfer to the oxidized particles was investigated using an assay measuring the transfer of fluorescent, pyrene-labeled PC. pyrene 133-139 phospholipid transfer protein Homo sapiens 0-4 9606968-12 1998 For example, mGSTA1, but not mGSTA2, subunit expression was observed in the skin, which is a target organ for benzo(a)pyrene (BP)-induced cancer in mice. pyrene 118-124 glutathione S-transferase, alpha 1 (Ya) Mus musculus 13-19 9450551-0 1997 Pyrene excimer fluorescence as a proximity probe for investigation of residual structure in the unfolded state of human carbonic anhydrase II. pyrene 0-6 carbonic anhydrase 2 Homo sapiens 120-141 9488689-1 1998 UDP-glucuronosyltransferase UGT1A7 catalyzes the glucuronidation of benzo(a)pyrene metabolites and other bulky aromatic compounds. pyrene 76-82 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 0-27 9488689-1 1998 UDP-glucuronosyltransferase UGT1A7 catalyzes the glucuronidation of benzo(a)pyrene metabolites and other bulky aromatic compounds. pyrene 76-82 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 28-34 9258441-2 1997 The recovered pyrene-labeled IFN-gamma (py-IFN-gamma), with an estimated seven pyrene molecules per IFN-gamma, retained over half of its original biological activity. pyrene 14-20 interferon gamma Homo sapiens 29-38 9258441-2 1997 The recovered pyrene-labeled IFN-gamma (py-IFN-gamma), with an estimated seven pyrene molecules per IFN-gamma, retained over half of its original biological activity. pyrene 79-85 interferon gamma Homo sapiens 43-52 9258441-2 1997 The recovered pyrene-labeled IFN-gamma (py-IFN-gamma), with an estimated seven pyrene molecules per IFN-gamma, retained over half of its original biological activity. pyrene 14-20 interferon gamma Homo sapiens 43-52 9258441-2 1997 The recovered pyrene-labeled IFN-gamma (py-IFN-gamma), with an estimated seven pyrene molecules per IFN-gamma, retained over half of its original biological activity. pyrene 79-85 interferon gamma Homo sapiens 43-52 9258441-2 1997 The recovered pyrene-labeled IFN-gamma (py-IFN-gamma), with an estimated seven pyrene molecules per IFN-gamma, retained over half of its original biological activity. pyrene 14-20 interferon gamma Homo sapiens 43-52 9258441-2 1997 The recovered pyrene-labeled IFN-gamma (py-IFN-gamma), with an estimated seven pyrene molecules per IFN-gamma, retained over half of its original biological activity. pyrene 79-85 interferon gamma Homo sapiens 29-38 9066009-6 1997 Finally, incorporation of pyrene-labeled GM3 into platelet membranes, followed by stimulation with adenosine diphosphate, resulted in the appearance of a fluorescent band comigrating with GD3. pyrene 26-32 GRDX Homo sapiens 188-191 9200859-12 1997 A positive correlation between total PAH levels and the pyrene levels was observed. pyrene 56-62 phenylalanine hydroxylase Homo sapiens 37-40 9228780-1 1997 Inoculation of soil with bacteria (a Gram-negative rod [PD2] and a 4-membered consortium [DC1]) accelerated mineralisation of phenanthrene and pyrene (but not naphthalene) added individually to a pristine sand and a pristine organic soil. pyrene 143-149 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 56-59 8810906-5 1996 Measurements of the solvent accessibility and segmental rotational dynamics of PMal-CaM bound to either the PM-Ca-ATPase or C25W further indicate that the local environment around the pyrene label located at Cys27 is very similar. pyrene 184-190 CaM5 Triticum aestivum 84-87 8933036-5 1996 This metabolite of pyrene can be measured as 1-OHP after deconjugation of the glucuronide with beta-glucuronidase or directly as 1-OHP-gluc without deconjugation. pyrene 19-25 glucuronidase beta Homo sapiens 95-113 9106248-9 1997 In order to begin to characterize the promutagen activating ability of CYP1B1, the mutagenicity of selected chemicals was examined in h1B1/OR cells; there was increased sensitivity (CYP1B1-expressing relative to control cells) to the mutagenicity of benzo(a)pyrene, cyclopenta(c,d)pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and aflatoxin B1 (AFB). pyrene 257-264 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 71-77 9070358-0 1997 Route-specific cellular expression of cytochrome P4501A (CYP1A) in fish (Fundulus heteroclitus) following exposure to aqueous and dietary benzo[a]pyrene. pyrene 146-152 cytochrome P450 1A1 Fundulus heteroclitus 57-62 8999837-12 1997 UGT1A7 appears to represent an important cellular chemoprotective enzyme which mediates conjugation and elimination of toxic benzo(a)pyrene metabolites. pyrene 133-139 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 0-6 8921548-12 1996 For unsaturated compounds (aromatics), one reference RfD was identified for all compounds: C9 through C32 (pyrene, 0.03 mg/kg/day). pyrene 107-113 chemokine like factor Homo sapiens 102-105 8694494-9 1996 The results presented in this investigation indicate that biological monitoring of the pyrene metabolite 1-hydroxypyrene is a useful indicator of a general PAH exposure, but cannot replace personal air sampling for assessing the lung cancer risk of individuals. pyrene 87-93 phenylalanine hydroxylase Homo sapiens 156-159 8552682-1 1996 Wild-type actin and a mutant actin were isolated from yeast (Saccharomyces cerevisiae) and the polymerization properties were examined at pH 8.0 and 20 degrees C. The polymerization reaction was followed either by an increase in pyrene-labeled actin fluorescence or by a decrease in intrinsic fluorescence in the absence of pyrene-labeled actin. pyrene 229-235 actin Saccharomyces cerevisiae S288C 29-34 8634092-0 1996 Preferential DNA damage in the p53 gene by benzo[a]pyrene metabolites in cytochrome P4501A1-expressing xeroderma pigmentosum group A cells. pyrene 51-57 tumor protein p53 Homo sapiens 31-34 8603357-0 1996 Elevated binding to URE/PEBP2 during the late stages of NNK and benzo[a]pyrene-induced carcinogenesis in A/J mice. pyrene 72-78 core binding factor beta Mus musculus 24-29 8625481-4 1996 32P-Postlabeling assays showed that MCL-5 cells (genetically engineered to express five human cytochromes P450 and microsomal epoxide hydrolase) formed characteristic adduct spots with benz[a]pyrene, benzo[g]chrysene, 7,12-dimethylbenz[a]anthracene, benzidine, sterigmatocystin and 3-methylcholanthrene, whereas CCRF cells did not. pyrene 192-198 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 106-143 8645154-5 1996 Direct analysis of the actin-severing activity of gelsolin by a fluorimetric assay using pyrene-labelled actin confirmed this conclusion. pyrene 89-95 gelsolin Homo sapiens 50-58 8636161-10 1996 Binding of erythrocytic beta-actin to ezrin is saturable with a molar ratio of approximately 1:10 (ezrin:actin) and a dissociation constant approximately 4.6 x 10(-8) M. In addition, ezrin promoted pyrene-labeled actin assembly, with predominant effects on filament elongation and a distinct preference for beta-actin compared with alpha-actin. pyrene 198-204 POTE ankyrin domain family member F Homo sapiens 24-34 8636161-10 1996 Binding of erythrocytic beta-actin to ezrin is saturable with a molar ratio of approximately 1:10 (ezrin:actin) and a dissociation constant approximately 4.6 x 10(-8) M. In addition, ezrin promoted pyrene-labeled actin assembly, with predominant effects on filament elongation and a distinct preference for beta-actin compared with alpha-actin. pyrene 198-204 ezrin Homo sapiens 38-43 15048450-2 1996 This sensor has been used for the simultaneous determination of PAH mixtures (pyrene, benzo(e)pyrene and benzo(ghi)perylene). pyrene 78-84 phenylalanine hydroxylase Homo sapiens 64-67 8552682-1 1996 Wild-type actin and a mutant actin were isolated from yeast (Saccharomyces cerevisiae) and the polymerization properties were examined at pH 8.0 and 20 degrees C. The polymerization reaction was followed either by an increase in pyrene-labeled actin fluorescence or by a decrease in intrinsic fluorescence in the absence of pyrene-labeled actin. pyrene 229-235 actin Saccharomyces cerevisiae S288C 29-34 8552682-1 1996 Wild-type actin and a mutant actin were isolated from yeast (Saccharomyces cerevisiae) and the polymerization properties were examined at pH 8.0 and 20 degrees C. The polymerization reaction was followed either by an increase in pyrene-labeled actin fluorescence or by a decrease in intrinsic fluorescence in the absence of pyrene-labeled actin. pyrene 229-235 actin Saccharomyces cerevisiae S288C 29-34 8552682-5 1996 Second, as measured with pyrene-labeled yeast actin, but not with intrinsic fluorescence, there is an overshoot in the fluorescence that has not been observed with skeletal muscle actin under the same conditions. pyrene 25-31 actin Saccharomyces cerevisiae S288C 46-51 8527457-2 1995 The effect of caldesmon (CaD) on local conformational changes in different regions of the tropomyosin molecule was determined on the basis of changes in the excimer fluorescence (excited dimer of pyrene) formed in homodimers of tropomyosin isoforms. pyrene 196-202 caldesmon 1 Homo sapiens 14-23 9394242-1 1996 The present study indicates that diesel exhaust particulates (DEP) and pyrene contained in DEP have an adjuvant activity on IgE and IgG1 antibody productions in mice immunized intranasally with a mite allergen. pyrene 71-77 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 132-136 9394242-2 1996 The effect of pyrene on IgE and IgG1 antibody productions in mice was investigated to clarify the relation between mite allergy and adjuvancy of the chemical compounds in DEP. pyrene 14-20 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 32-36 9394242-8 1996 The IgG1 antibody responses to Der f II in mice immunized with 10 micrograms of Der f II plus 200 micrograms of pyrene or 10 micrograms of Der f II plus 100 micrograms of DEP were extremely higher than those immunized with 10 micrograms of Der f II alone. pyrene 112-118 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 4-8 9394242-9 1996 In addition, when the peritoneal macrophages obtained from normal mice were incubated with pyrene or DEP in vitro, an enhanced interleukin-1 alpha production of the macrophages was observed. pyrene 91-97 interleukin 1 alpha Mus musculus 127-146 9394242-11 1996 These results suggest that the adjuvancy of DEP and pyrene on the production of IgE and IgG1 antibodies to Der f II may be one of the factors responsible for an incidence of asthma caused by house dust mite. pyrene 52-58 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 88-92 8546695-6 1996 When PyrPC-rHDL was incubated with HDL3 in the presence of PLTP, a rapid decline of the pyrene excimer/monomer fluorescence ratio (E/M) occurred, demonstrating that PLTP induced mixing of the surface lipids of PyrPC-rHDL and HDL3. pyrene 88-94 HDL3 Homo sapiens 35-39 8546695-6 1996 When PyrPC-rHDL was incubated with HDL3 in the presence of PLTP, a rapid decline of the pyrene excimer/monomer fluorescence ratio (E/M) occurred, demonstrating that PLTP induced mixing of the surface lipids of PyrPC-rHDL and HDL3. pyrene 88-94 phospholipid transfer protein Homo sapiens 59-63 8546695-6 1996 When PyrPC-rHDL was incubated with HDL3 in the presence of PLTP, a rapid decline of the pyrene excimer/monomer fluorescence ratio (E/M) occurred, demonstrating that PLTP induced mixing of the surface lipids of PyrPC-rHDL and HDL3. pyrene 88-94 phospholipid transfer protein Homo sapiens 165-169 8991066-0 1996 Mutagenic response of the endogenous hprt gene and lacI transgene in benzo[a]pyrene-treated Big Blue B6C3F1 mice. pyrene 77-83 hypoxanthine guanine phosphoribosyl transferase Mus musculus 37-41 8991066-0 1996 Mutagenic response of the endogenous hprt gene and lacI transgene in benzo[a]pyrene-treated Big Blue B6C3F1 mice. pyrene 77-83 tissue factor pathway inhibitor Mus musculus 51-55 8527457-2 1995 The effect of caldesmon (CaD) on local conformational changes in different regions of the tropomyosin molecule was determined on the basis of changes in the excimer fluorescence (excited dimer of pyrene) formed in homodimers of tropomyosin isoforms. pyrene 196-202 caldesmon 1 Homo sapiens 25-28 8527457-3 1995 In the absence of actin, excimer fluorescence from the pyrene at Cys-190 of gamma-tropomyosin homodimer decreased in a simple manner on the addition of CaD, whereas the excimer from the Cys-36 of beta-tropomyosin homodimer exhibited a biphasic change, suggesting that additional weak binding sites exist near Cys-36. pyrene 55-61 caldesmon 1 Homo sapiens 152-155 8600835-13 1995 The action of sPLA2 on this fluorescent substrate leads to a separation of the pyrene chains resulting in fluorescence emission from monomeric pyrene. pyrene 79-85 phospholipase A2 group IIA Homo sapiens 14-19 8847147-3 1995 In uncrowded (Td, 18 hr) and crowded (Td, 32 hr) cultures of benzo[a]pyrene-transformed cells intracellular CD levels were one third and two thirds, respectively, of those measured in hyperconfluent 3T3 cultures. pyrene 69-75 cathepsin D Mus musculus 108-110 8600835-4 1995 The cPLA2 assays can be carried out in a fixed time-point mode in which one of the products, the pyrene-containing lysophospholipid, is detected by rapid HPLC. pyrene 97-103 phospholipase A2 group IVA Homo sapiens 4-9 8600835-5 1995 Alternatively, the assay becomes continuous when bovine serum albumin is present in the aqueous phase; this protein extracts the pyrene-containing lysophospholipid from the vesicle, and this leads to the fluorescence of monomeric pyrene label. pyrene 129-135 albumin Homo sapiens 56-69 8713749-1 1995 The dependence of microsomal glucose-6-phosphatase (G-6-Pase) activity on Ca2+ as well as the membrane lipid microviscosity was studied by the effect of Ca(2+)-channel blockers (namely verapamil and nifedipine), Ca(2+)-ionophore, A23187 and pyrene excimer formation. pyrene 241-247 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 29-50 8600835-5 1995 Alternatively, the assay becomes continuous when bovine serum albumin is present in the aqueous phase; this protein extracts the pyrene-containing lysophospholipid from the vesicle, and this leads to the fluorescence of monomeric pyrene label. pyrene 230-236 albumin Homo sapiens 56-69 7578043-1 1995 Association and dissociation rates for the pyrene-(pyr)-labeled oligoribonucleotide substrate pyrCUCU binding to the L-21 ScaI group I ribozyme are reported as a function of temperature. pyrene 43-49 ribosomal protein L21 Homo sapiens 117-121 8713749-0 1995 Effect of Ca(2+)-channel blockers, Ca(2+)-ionophore and increased pyrene excimer formation on the microsomal glucose-6-phosphatase. pyrene 66-72 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 109-130 7574713-7 1995 Introduction of an antisense 24-mer oligonucleotide to glycine N-methyltransferase cDNA into rat hepatoma H4IIE cells by lipofectin resulted in a 60% reduction in the benzo(a)pyrene-mediated induction of ethoxyresorufin-O-deethylase activity and protein over the sense and scrambled antisense oligonucleotide controls. pyrene 175-181 glycine N-methyltransferase Rattus norvegicus 55-82 7574713-9 1995 Introduction of GNMT polyclonal antibodies into H4IIE cells by a streptolysin-O permeabilization technique markedly reduced both benzo(a)pyrene-binding and benzo(a)-pyrene-induced ethoxyresorufin-O-deethylase activities, but had no effect on 2,3,7,8-tetrachlorodibenzo-p-dioxin induction. pyrene 137-143 glycine N-methyltransferase Rattus norvegicus 16-20 8713749-1 1995 The dependence of microsomal glucose-6-phosphatase (G-6-Pase) activity on Ca2+ as well as the membrane lipid microviscosity was studied by the effect of Ca(2+)-channel blockers (namely verapamil and nifedipine), Ca(2+)-ionophore, A23187 and pyrene excimer formation. pyrene 241-247 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 52-60 8713749-5 1995 Excimer formation of the fluorescent probe, pyrene as an indicator of increased membrane fluidity, and microviscosity calculated from there on, showed that Ca(2+)- and lipid microenvironment in the membrane significantly influenced the activity of G-6-Pase. pyrene 44-50 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 248-256 7561049-4 1995 GM-CSF augmented benzo(a)pyrene metabolism in XS52 cells. pyrene 25-31 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 0-6 7663513-0 1995 A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice. pyrene 49-55 transformation related protein 53, pseudogene Mus musculus 34-37 8567938-2 1995 The bent "hairpin" form of caldesmon was enhanced between pH 6.0 and 8.0 and at low ionic strengths, as reported by an increase in excimer fluorescence of pyrene-labelled caldesmon under these conditions. pyrene 155-161 caldesmon 1 Homo sapiens 27-36 8567938-2 1995 The bent "hairpin" form of caldesmon was enhanced between pH 6.0 and 8.0 and at low ionic strengths, as reported by an increase in excimer fluorescence of pyrene-labelled caldesmon under these conditions. pyrene 155-161 caldesmon 1 Homo sapiens 171-180 8567938-4 1995 Titrations of pyrene caldesmon with actin, heavy meromyosin, and calmodulin resulted in a decrease in excimer fluorescence. pyrene 14-20 caldesmon 1 Homo sapiens 21-30 8567938-4 1995 Titrations of pyrene caldesmon with actin, heavy meromyosin, and calmodulin resulted in a decrease in excimer fluorescence. pyrene 14-20 calmodulin 1 Homo sapiens 65-75 7768899-1 1995 Steady-state fluorescence polarization was used to examine the chaperonin cpn60 that was covalently labeled with pyrene. pyrene 113-119 heat shock protein family D (Hsp60) member 1 Homo sapiens 74-79 7666493-5 1995 Immunoinhibition of these activities and Western blotting of hepatic microsomes using antibodies against cytochrome P-450 isozymes suggested that the isozymes responsible for benzo[a]pyrene metabolism in Syrian hamsters belong to the CYP1A, CYP2A, and CYP3A families, a result that differs from observations in rats. pyrene 183-189 cytochrome P450 2A3-like Mesocricetus auratus 105-121 7768899-2 1995 Two compounds, 1-pyrenesulfonyl chloride or N-(1-pyrene)maleimide, were used to incorporate up to 8 mol of pyrene per mol of cpn60 14-mer. pyrene 17-23 heat shock protein family D (Hsp60) member 1 Homo sapiens 125-130 7663513-0 1995 A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice. pyrene 49-55 transformation related protein 53, pseudogene Mus musculus 75-78 7592554-3 1995 The measurement of resonance energy transfer from PMI to 1-(dimethylaminophenyl)-6-phenyl-1,3,5-hexatriene revealed that the pyrene moiety of PMI stayed in the lipid layer after it had been covalently attached to the ATPase molecule. pyrene 125-131 dynein axonemal heavy chain 8 Homo sapiens 217-223 7766306-0 1995 Benzo[a]pyrene-induced mutagenesis of p53 hot-spot codons 248 and 249 in human hepatocytes. pyrene 8-14 tumor protein p53 Homo sapiens 38-41 7766306-1 1995 Human tobacco-related cancers show a high frequency of G-to-T transversions in several mutation hot-spot regions of the p53 tumor suppressor gene, probably the result of specific mutagens in tobacco smoke, most notably benzo[a]pyrene. pyrene 227-233 tumor protein p53 Homo sapiens 120-123 7766306-2 1995 To gain insight into the mechanism of formation of these G-to-T transversions in tobacco-associated carcinogenesis, we studied the mutagenesis of p53 codons 247-250 by benzo[a]pyrene in human hepatocellular carcinoma cells by restriction fragment length polymorphism-polymerase chain reaction genotypic analysis. pyrene 176-182 tumor protein p53 Homo sapiens 146-149 7526191-0 1994 Processing of MucA protein is required for spontaneous and benzo[a]pyrene-induced reversion of the Escherichia coli trpA23 missense mutation by G.C-T.A transversions: effect of a deficiency in the MutY DNA glycosylase. pyrene 67-73 MucA Escherichia coli 14-18 7880810-4 1995 This BP-11-mer duplex exhibits NOESY cross-peaks between benzo[a]pyrene protons and BP-G8, C9, A16, and C17 nucleotide protons that clearly delineate the location of the BP moiety in the minor groove of a B-type duplex with the pyrene ring oriented toward the 5" end of the modified strand. pyrene 65-71 cytokine like 1 Homo sapiens 104-107 7880810-5 1995 Large upfield shifts of A16 and C17 sugar resonances in the partner strand show that the pyrene moiety is situated near these sugars. pyrene 89-95 cytokine like 1 Homo sapiens 32-35 7803401-13 1994 The transport of pyrene-labeled triglyceride from donor particles to MTP was rapid, while phosphatidylcholine transfer had fast and slow phases. pyrene 17-23 microsomal triglyceride transfer protein Homo sapiens 69-72 7890614-5 1995 An extrinsic fluorescence reporter group, pyrene maleimide, attached to bovine rhodopsin also shows an increase in pyrene fluorescence on illumination. pyrene 42-48 rhodopsin Bos taurus 79-88 7873593-1 1995 Binding of cholera toxin B protomer (CT-B) to a pyrene-labeled analogue of its ganglioside GM1 receptor (pyrene-GM1) in the absence and presence of phosphatidylcholine vesicles was monitored using steady-state fluorescence spectroscopy. pyrene 48-54 phosphate cytidylyltransferase 1B, choline Homo sapiens 11-35 7873593-1 1995 Binding of cholera toxin B protomer (CT-B) to a pyrene-labeled analogue of its ganglioside GM1 receptor (pyrene-GM1) in the absence and presence of phosphatidylcholine vesicles was monitored using steady-state fluorescence spectroscopy. pyrene 48-54 phosphate cytidylyltransferase 1B, choline Homo sapiens 37-41 20693099-1 1994 Cytotoxicity and mutagenicity were measured in human lymphocytes after treatment in vitro with anti- or syn-benzo[a]pyrene diolepoxide, two diastereoisomer metabolites of benzo[a]pyrene. pyrene 116-122 synemin Homo sapiens 104-107 7808430-5 1994 TGF-beta 1 proved to be the most effective cytokine, because 72 hr of treatment with 2 ng/ml TGF-beta 1 produced nearly 100% inhibition of 3-MC- and benzo(a)pyrene-induced CYP1A1 and CYP1A2 mRNAs and EROD activity. pyrene 157-163 transforming growth factor beta 1 Homo sapiens 0-10 7808430-5 1994 TGF-beta 1 proved to be the most effective cytokine, because 72 hr of treatment with 2 ng/ml TGF-beta 1 produced nearly 100% inhibition of 3-MC- and benzo(a)pyrene-induced CYP1A1 and CYP1A2 mRNAs and EROD activity. pyrene 157-163 transforming growth factor beta 1 Homo sapiens 93-103 7808430-5 1994 TGF-beta 1 proved to be the most effective cytokine, because 72 hr of treatment with 2 ng/ml TGF-beta 1 produced nearly 100% inhibition of 3-MC- and benzo(a)pyrene-induced CYP1A1 and CYP1A2 mRNAs and EROD activity. pyrene 157-163 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 172-178 8204093-7 1994 Significant correlations (r = 0.87-0.97, P < 0.001) were observed between CA 8-hydroxylation and immunoreactive CYP3A content and the CYP3A-mediated reactions benzo(a)pyrene hydroxylation, omeprazole sulfoxidation and aflatoxin B1 mutagenesis. pyrene 170-176 carbonic anhydrase 8 Homo sapiens 77-81 7747336-3 1994 Efficiency of the inductive-resonance energy transfer from the membrane tryptophenyls to pyrene was raised at 10 days postirradiation indicative on the lipid-protein alterations within membrane matrix, gamma-irradiation was characterized by the following features of 5"-nucleotidase; (1) two-fold increasing of Michaelis constant Km and (2) raising by 3-4 degrees C of the breakpoint on the enzyme Arrhenius plot. pyrene 89-95 5' nucleotidase, ecto Rattus norvegicus 267-282 8055911-4 1994 Polymerization of actin was verified by the DNase I inhibition assay, by cosedimentation and from the fluorescence increase of pyrene-labelled actin. pyrene 127-133 actin, beta Gallus gallus 18-23 8055911-4 1994 Polymerization of actin was verified by the DNase I inhibition assay, by cosedimentation and from the fluorescence increase of pyrene-labelled actin. pyrene 127-133 actin, beta Gallus gallus 143-148 8011667-4 1994 In this paper, we show additional evidence that the rate of salt-induced increase in the fluorescence of pyrene-labeled actin was decreased in the presence of the 2.6 kDa peptide. pyrene 105-111 actin Oryctolagus cuniculus 120-125 8011667-8 1994 However, the 9.1 kDa peptide was found to increase the viscosity and fluorescence intensity of pyrene-G-actin and to form short actin filaments in the absence of salts. pyrene 95-101 actin Oryctolagus cuniculus 104-109 8204093-7 1994 Significant correlations (r = 0.87-0.97, P < 0.001) were observed between CA 8-hydroxylation and immunoreactive CYP3A content and the CYP3A-mediated reactions benzo(a)pyrene hydroxylation, omeprazole sulfoxidation and aflatoxin B1 mutagenesis. pyrene 170-176 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 115-120 8204093-7 1994 Significant correlations (r = 0.87-0.97, P < 0.001) were observed between CA 8-hydroxylation and immunoreactive CYP3A content and the CYP3A-mediated reactions benzo(a)pyrene hydroxylation, omeprazole sulfoxidation and aflatoxin B1 mutagenesis. pyrene 170-176 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 137-142 8323572-2 1993 Pyrene-labeled, small subunit ADA was applied to cultured (normal) CEF, which have available and abundant ADA complexing protein (ADCP) on their plasma membranes. pyrene 0-6 adenosine deaminase Homo sapiens 30-33 8170947-7 1994 Concurrently, as NO production in hepatocytes increased within 24 hr, a decrease in CYP1A1-dependent benzo[a]pyrene turnover was observed to almost undetectable levels. pyrene 109-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 84-90 7504446-1 1993 In this communication, it is shown that pyrene has an adjuvant activity on IgE antibody production when mice are immunized by an intraperitoneal injection of ovalbumin (OA) or Japanese cedar pollen allergen (JCPA) with pyrene. pyrene 40-46 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 158-167 7516235-3 1994 This latter nucleotide change results in an altered amino acid (462Ile-->Val), which is purported to increase CYP1A1 enzyme activity and mutagenicity towards benzo[a]pyrene about two-fold among Japanese. pyrene 169-175 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 8399189-6 1993 This model for lipid transport was supported by a fluorescent lipid binding assay in which MTP was able to extract pyrene-labeled cholesteryl ester from a vesicle. pyrene 115-121 microsomal triglyceride transfer protein Homo sapiens 91-94 8388718-1 1993 As revealed by resonance energy transfer utilizing pyrene-labeled phosphatidylcholine donor, the mainly electrostatically controlled binding of adriamycin (Adr) and cytochrome c (cyt c) to mixed egg yolk phosphatidic acid/phosphatidylcholine (eggPA/eggPC, 15:85 molar ratio) liposomes was reversed upon the inclusion of increasing contents of sphingosine. pyrene 51-57 cytochrome c, somatic Homo sapiens 165-177 8388718-1 1993 As revealed by resonance energy transfer utilizing pyrene-labeled phosphatidylcholine donor, the mainly electrostatically controlled binding of adriamycin (Adr) and cytochrome c (cyt c) to mixed egg yolk phosphatidic acid/phosphatidylcholine (eggPA/eggPC, 15:85 molar ratio) liposomes was reversed upon the inclusion of increasing contents of sphingosine. pyrene 51-57 cytochrome c, somatic Homo sapiens 179-184 8388718-7 1993 For comparison we also studied the effects of sphingosine on the phospholipase A2 catalyzed hydrolysis of the pyrene-labeled acidic alkylacyl phospholipid analog 1-octacosanyl-2-[6-(pyren-1-yl)]hexanoyl-sn-glycero-3- phosphatidylmethanol (C28-O-PHPM) and the corresponding phosphatidylcholine (C28-O-PHPC). pyrene 110-116 phospholipase A2 group IB Homo sapiens 65-81 8430068-0 1993 Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene. pyrene 8-14 transformation related protein 53, pseudogene Mus musculus 102-105 8430068-1 1993 Human tobacco-related cancers exhibit a high frequency of G to T transversions in the mutation hot spot region of the p53 tumor suppressor gene, possibly the result of specific mutagens in tobacco smoke, most notably benzo[a]pyrene (B[a]P). pyrene 225-231 tumor protein p53 Homo sapiens 118-121 8422369-7 1993 The simultaneous recordings of PLA2 activity and pyrene fluorescence show that the lateral rearrangement of lipids begins prior to and continues during the rapid activation process of PLA2. pyrene 49-55 phospholipase A2 group IIA Homo sapiens 184-188 8323572-2 1993 Pyrene-labeled, small subunit ADA was applied to cultured (normal) CEF, which have available and abundant ADA complexing protein (ADCP) on their plasma membranes. pyrene 0-6 adenosine deaminase Homo sapiens 106-109 1333237-4 1992 The emission from pyrenyl-gelsolin was dominated by a broad emission band centred near 483 nm, characteristic of the presence of pyrene excimers. pyrene 129-135 gelsolin Equus caballus 26-34 1335374-5 1992 Only those congeners which bound to the aryl hydrocarbon (Ah) receptor, namely benzo[a]pyrene, benz[a]anthracene, 7,12-dimethylbenz[a]anthracene and MC, caused a decrease in nuclear ER levels. pyrene 87-93 aryl hydrocarbon receptor Homo sapiens 40-70 1445851-2 1992 To monitor binding between retinol-binding protein (RBP) and transthyretin (TTR), TTR was labeled with a long-lived fluorescence probe (pyrene). pyrene 136-142 retinol binding protein 4 Homo sapiens 27-50 1445851-2 1992 To monitor binding between retinol-binding protein (RBP) and transthyretin (TTR), TTR was labeled with a long-lived fluorescence probe (pyrene). pyrene 136-142 retinol binding protein 4 Homo sapiens 52-55 1445851-2 1992 To monitor binding between retinol-binding protein (RBP) and transthyretin (TTR), TTR was labeled with a long-lived fluorescence probe (pyrene). pyrene 136-142 transthyretin Homo sapiens 61-74 1445851-2 1992 To monitor binding between retinol-binding protein (RBP) and transthyretin (TTR), TTR was labeled with a long-lived fluorescence probe (pyrene). pyrene 136-142 transthyretin Homo sapiens 82-85 1333237-6 1992 In the case either of excimer formation or of ground-state pyrene-pyrene interactions in doubly labelled gelsolin molecules, the modified Cys residues must be in close proximity in the folded protein structure. pyrene 59-65 gelsolin Equus caballus 105-113 1333237-6 1992 In the case either of excimer formation or of ground-state pyrene-pyrene interactions in doubly labelled gelsolin molecules, the modified Cys residues must be in close proximity in the folded protein structure. pyrene 66-72 gelsolin Equus caballus 105-113 1333237-9 1992 Also, pyrenyl-gelsolin prepared and studied in 6 M guanidine-HCl exhibited fluorescence characteristic of pyrene monomers exclusively. pyrene 106-112 gelsolin Equus caballus 14-22 1537398-1 1992 1H nuclear magnetic resonance longitudinal relaxation time (T1) measurements were used to study the interaction of 1,3,6-H-benzo(a)pyrene (1,3,6-H-BaP) with microsomal cytochrome P-450 from livers of phenobarbital- and beta-naphthoflavone-treated rats. pyrene 131-137 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 168-184 1581336-1 1992 The interactions of salmon calcitonin with glycosphingolipid sulfatide are studied by right angle light scattering from the lipid suspension, by the excimer to monomer ratio (E/M) of the fluorescence intensity of pyrene phosphatidylcholine and pyrene sulfatide and by the leakage of carboxyfluorescein. pyrene 213-219 calcitonin related polypeptide alpha Homo sapiens 27-37 1543731-4 1992 The interaction of lysozyme with the vesicle bilayer was characterized by measuring resonance energy transfer from tryptophane, present in the protein, to pyrene. pyrene 155-161 lysozyme Homo sapiens 19-27 1594885-5 1992 The phospholipase A2 activities from enzymes purified from human duodenal juice, human sera from patients with sepsis and rat liver mitochondria were characterized in regard to activity towards several synthetic pyrene-labelled substrates, activation by Ca2+ and inhibition by Sr2+ and Mg2+. pyrene 212-218 phospholipase A2 group IB Homo sapiens 4-20 1636063-8 1992 The results obtained with five independently established in vitro bladder carcinoma cell lines indicated that these cells are susceptible to P12-induced photosensitization, suggesting that bladder malignancies might be potential candidates for pyrene-induced photochemotherapy. pyrene 244-250 DNA polymerase epsilon 4, accessory subunit Homo sapiens 141-144 1309295-0 1992 Mechanism of benzo[a]pyrene-induced Cyp1a-1 gene expression in mouse Hepa 1c1c7 cells: role of the nuclear 6 s and 4 s proteins. pyrene 21-27 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 36-43 1459043-0 1992 Relationship between activities of cytochrome P-450 monooxygenases in human placental microsomes and binding of benzo(a)pyrene metabolites to calf thymus DNA. pyrene 120-126 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 35-51 1756513-2 1991 We have recently identified and characterized IgA directed against a "benzo[a]pyrene-like" antigen in sera of patients with mammary tumors. pyrene 78-84 immunoglobulin heavy variable 4-38-2-like Homo sapiens 46-49 2016303-8 1991 This was indicated by the following observations in the Tm.TnT complex compared to the Tm-troponin complex: (i) a more hydrophobic environment of pyrene at Cys-190 of Tm; (ii) stabilization against the local unfolding of Tm near Cys-190; (iii) more fluorescence resonance energy transfer between Tm and TnT. pyrene 146-152 troponin T1, slow skeletal type Homo sapiens 59-62 1953663-2 1991 The co-operative binding of myosin subfragment 1 (S1) to reconstituted skeletal-muscle thin filaments has been examined by monitoring the fluorescence of a pyrene probe on Cys-374 of actin. pyrene 156-162 myosin heavy chain 14 Homo sapiens 28-34 1834210-2 1991 By immunoblotting analysis with the antibodies raised against P-450/B[a]P, which is a form of cytochrome P-450 catalyzing benzo[a]pyrene hydroxylation in liver microsomes of untreated rats, it was shown that P-450/B[a]P content was decreased in the microsomes prepared from the nodular tissues. pyrene 130-136 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 62-69 1834210-2 1991 By immunoblotting analysis with the antibodies raised against P-450/B[a]P, which is a form of cytochrome P-450 catalyzing benzo[a]pyrene hydroxylation in liver microsomes of untreated rats, it was shown that P-450/B[a]P content was decreased in the microsomes prepared from the nodular tissues. pyrene 130-136 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 94-110 2007582-4 1991 Under similar conditions adriamycin also enhanced the rate of hydrolysis of the pyrene-labeled diacyl lipid 1-palmitoyl-2-(pyren-1-yl)hexanoyl-sn-glycero-3-phosphatidylgly cer ol and inhibited the hydrolysis of PLA2 on the phosphatidylcholine derivative. pyrene 80-86 phospholipase A2 group IB Homo sapiens 211-215 2016303-8 1991 This was indicated by the following observations in the Tm.TnT complex compared to the Tm-troponin complex: (i) a more hydrophobic environment of pyrene at Cys-190 of Tm; (ii) stabilization against the local unfolding of Tm near Cys-190; (iii) more fluorescence resonance energy transfer between Tm and TnT. pyrene 146-152 troponin T1, slow skeletal type Homo sapiens 303-306 2202898-1 1990 We have previously reported that the beta-glucuronidase-treated urine of mice injected intraperitoneally with pyrene during exposure to NO2 contained highly mutagenic compounds such as nitropyrene metabolites when tested by the Ames assay using Salmonella typhimurium strain TA98. pyrene 110-116 glucuronidase, beta Mus musculus 37-55 1826088-2 1991 In this study, experiments are presented that utilize a pyrene derivative of phosphatidylcholine to examine the Ca2(+)-dependent membrane binding of soluble human annexin V and other annexins. pyrene 56-62 annexin A5 Homo sapiens 163-172 1901225-3 1991 When human apolipoproteins A-I or A-II are present in the reaction mixture enough to saturate the surface of the emulsion, the enhancement of the pyrene-cholesteryl ester transfer reaction by the transfer protein was 7.5-times more than in the absence of the apolipoproteins while the rate of spontaneous transfer was not affected significantly by the apolipoproteins. pyrene 146-152 NLR family pyrin domain containing 3 Homo sapiens 11-38 1845966-1 1991 The reactions of pyrene-labeled actin with myosin subfragment 1 (S1) and S1-ligand complexes at low ionic strength are described by the schemes [formula: see text] where M refers to a myosin head; A is actin; L is ligand; the asterisk refers to a high fluorescence state of actin; and K1 and K3 are association constants. pyrene 17-23 myosin heavy chain 14 Homo sapiens 43-49 1845966-1 1991 The reactions of pyrene-labeled actin with myosin subfragment 1 (S1) and S1-ligand complexes at low ionic strength are described by the schemes [formula: see text] where M refers to a myosin head; A is actin; L is ligand; the asterisk refers to a high fluorescence state of actin; and K1 and K3 are association constants. pyrene 17-23 myosin heavy chain 14 Homo sapiens 184-190 1845966-1 1991 The reactions of pyrene-labeled actin with myosin subfragment 1 (S1) and S1-ligand complexes at low ionic strength are described by the schemes [formula: see text] where M refers to a myosin head; A is actin; L is ligand; the asterisk refers to a high fluorescence state of actin; and K1 and K3 are association constants. pyrene 17-23 keratin 1 Homo sapiens 285-294 2096947-1 1990 Antibodies to mouse liver cytochrome P3-450 (anti-P3-450) and antibodies to rat liver cytochrome P-450d (anti-P-450d-c) inhibit the 0-deethylation of 7-ethoxyresorufin (ER) in liver microsomes of benz(a)pyrene-induced (BP) mice but do not inhibit the 0-deethylase activity in liver microsomes of BP-induced rats. pyrene 203-209 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 86-103 19431774-1 1990 PYRENE FLUORESCENCE QUENCHING BY PLASTOQUINONE WAS USED TO ESTIMATE THE RATE OF PLASTOQUINONE LATERAL DIFFUSION IN SOYBEAN PHOSPHATIDYLCHOLINE PROTEOLIPOSOMES CONTAINING THE FOLLOWING INTEGRAL MEMBRANE PROTEINS: gramicidin D, spinach cytochrome bf complex, spinach cytochrome f, reaction centers from Rhodobacter sphaeroides, beef heart mitochondrial cytochrome bc(1), and beef heart mitochondrial cytochrome oxidase. pyrene 0-6 apocytochrome f precursor Spinacia oleracea 265-277 2275212-2 1990 Antibodies to mouse liver cytochrome P3-450 (anti-P3-450) and antibodies to rat liver cytochrome P-450d (anti-P-450d-c) both inhibit the O-deethylation of 7-ethoxy-resorufin (ER) in liver microsomes of benzo(a)pyrene-induced (BP) mice but do not inhibit the O-deethylase activity in liver microsomes of BP-induced rats. pyrene 210-216 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 86-103 2303106-1 1990 Irradiation with long-wave UV light (LUV) at 366 nm of cells that had been incubated with 12-(1-pyrene)dodecanoic acid (P12), a fatty acid derivative with a covalently linked pyrene nucleus, resulted in cytotoxicity. pyrene 96-102 DNA polymerase epsilon 4, accessory subunit Homo sapiens 120-123 1693185-1 1990 The regulation of c-fos expression was studied in the untransformed A31 Balb/c 3T3 mouse fibroblast cell line and in the derivative benzo(a)pyrene (BPA31), dimethylbenz(a)anthracene (DA31) and the Kirsten sarcoma virus (KA31) transformed cell lines. pyrene 140-146 FBJ osteosarcoma oncogene Mus musculus 18-23 2159335-1 1990 A method is reported for the synthesis of pyrene-labeled analogues of phosphatidylinositol 4-phosphate (Pyr-PIP) and phosphatidylinositol 4,5-biphosphate (Pyr-PIP2) from sn-2-(pyrenyl-decanoyl)phosphatidylinositol (Pyr-PI) using partially purified PI and PIP kinase preparations. pyrene 42-48 prolactin induced protein Homo sapiens 108-111 2159335-1 1990 A method is reported for the synthesis of pyrene-labeled analogues of phosphatidylinositol 4-phosphate (Pyr-PIP) and phosphatidylinositol 4,5-biphosphate (Pyr-PIP2) from sn-2-(pyrenyl-decanoyl)phosphatidylinositol (Pyr-PI) using partially purified PI and PIP kinase preparations. pyrene 42-48 prolactin induced protein Homo sapiens 159-162 2159335-5 1990 The pyrene excimer/monomer fluorescence technique revealed that, in contrast to Pyr-PI, Pyr-PIP and Pyr-PIP2 formed clusters in organic solvents. pyrene 4-10 prolactin induced protein Homo sapiens 92-95 2115521-9 1990 The anisotropy decay of synapsin I labeled with the long-living chromophore pyrene on Cys-223 was also analyzed. pyrene 76-82 synapsin I Homo sapiens 24-34 2097281-1 1990 In the present study we have examined the effect of treatment with benz(a)-anthracene (BaA), pyrene (P) and fluoranthene (Fl) on the total liver microsomal content of cytochrome P-450 and elimination of these PAH from blood in rats. pyrene 93-99 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 167-183 25811539-1 2015 Three pyrene fused PDI derivatives have been obtained, in which totally different properties were observed when adopting different fusing types. pyrene 6-12 peptidyl arginine deiminase 1 Homo sapiens 19-22 34818808-6 2022 The results show that pyrene biodegradation on montmorillonite was markedly influenced by surface metal ions, with degradation efficiency following the order Fe(III) > Na(I) Co(II) > Ni(II) Cu(II). pyrene 22-28 mitochondrially encoded cytochrome c oxidase II Homo sapiens 176-182 34923382-1 2022 A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time. pyrene 129-135 citrate synthase Homo sapiens 31-33 34923382-5 2022 A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent. pyrene 2-8 citrate synthase Homo sapiens 158-160 34699769-5 2022 By using pyrene-labelled cholesterol and the environmental probe di-4-ANEPPDHQ, we observed that in model membranes, AnxA2 is able to modify both, cholesterol distribution and lipid compaction. pyrene 9-15 annexin A2 Homo sapiens 117-122 34818808-4 2022 To address this knowledge gap, pyrene was used as a model compound to investigate the biodegradation of polycyclic aromatic hydrocarbon on montmorillonite mineral saturated with metal ions (Na(I), Ni(II), Co(II), Cu(II) and Fe(III)) by Mycobacteria strain NJS-1. pyrene 31-37 mitochondrially encoded cytochrome c oxidase II Homo sapiens 205-211 34800719-0 2022 KIF11, a plus end-directed kinesin, as a key gene in benzo(a)pyrene-induced non-small cell lung cancer. pyrene 61-67 kinesin family member 11 Homo sapiens 0-5 34388430-8 2022 In this study, a novel lysosome probe, 4-(4-Pyren-1-yl-but-3-enyl)-morpholine (PIM), was synthesized using pyrene as a fluorescent group and morpholine as a target group. pyrene 107-113 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 79-82 34609168-7 2021 c-di-GMP activates the transcription of DPR-1 and DPR-2 to positively regulate degradation pathways specific to pyrene and phenanthrene/naphthalene, respectively. pyrene 112-118 5'-nucleotidase, cytosolic II Homo sapiens 5-8 34392205-1 2021 Pyrene is a model contaminant of high molecular weight polycyclic aromatic hydrocarbons (HMW-PAHs), which are compounds that have potential carcinogenic effects and pose a serious threat to human health. pyrene 0-6 cilia and flagella associated protein 97 Homo sapiens 89-92 34713879-2 2021 The foldamers with pyrene acetenyl units exhibit red excimer emissions, which were circularly polarized and show interesting circularly polarized luminescence properties with high CPL brightness BCPL up to 109.8 M-1.cm-1. pyrene 19-25 hephaestin Homo sapiens 180-183 34713879-3 2021 The red excimer CPL was attributed to the extended conjugations and the spatial restriction of pyrene units at the same side of foldamers. pyrene 95-101 hephaestin Homo sapiens 16-19 34814686-2 2021 Pyrene (Pyr) and triarylamine (TAA) moieties connected via phenylene Bs of various lengths are studied because their CS and CR behaviors can be readily monitored in real time by femtosecond transient absorption (fs-TA) spectroscopy. pyrene 0-6 citrate synthase Homo sapiens 117-119 34695688-1 2021 In this study, the sorption behaviors and mechanisms between polystyrene microplastics (micro-PS) and 4-rings polycyclic aromatic hydrocarbons (PAHs) pyrene (Pyr) and its derivatives (S-Pyr), including 1-methylpyrene (P-CH3), 1-hydroxypyrene (P-OH), 1-aminopyrene (P-NH2), 1-pyrenecarboxylic acid (P-COOH) were investigated at neutrality. pyrene 150-156 phosphatidylinositol glycan anchor biosynthesis class T Homo sapiens 265-270 34695688-3 2021 Meanwhile, -CH3 could slightly facilitate the sorption, whereas -OH, P-NH2, and P-COOH intensively inhibit the sorption of S-Pyr onto micro-PS. pyrene 123-128 phosphatidylinositol glycan anchor biosynthesis class T Homo sapiens 69-74 34609168-7 2021 c-di-GMP activates the transcription of DPR-1 and DPR-2 to positively regulate degradation pathways specific to pyrene and phenanthrene/naphthalene, respectively. pyrene 112-118 dishevelled binding antagonist of beta catenin 1 Homo sapiens 40-45 34609168-7 2021 c-di-GMP activates the transcription of DPR-1 and DPR-2 to positively regulate degradation pathways specific to pyrene and phenanthrene/naphthalene, respectively. pyrene 112-118 dishevelled binding antagonist of beta catenin 2 Homo sapiens 50-55 35583491-0 2022 Integrated Approach to Interaction Studies of Pyrene Derivatives with Bovine Serum Albumin: Insights from Theory and Experiment. pyrene 46-52 albumin Homo sapiens 77-90 34337268-2 2021 Montmorillonite is one of the best-known examples, and the modification with octadecyltrimethylammonium ion (Mont-C18) results in adsorption of anthracene and pyrene together with specific excimer emission, while the nanostructure is yet to be uncovered at the molecular level because the gallery height is only ca. pyrene 159-165 Bardet-Biedl syndrome 9 Homo sapiens 114-117 34361186-1 2021 A pyrene-based derivative, 2-((pyrene-1-ylmethylene)amino)ethanol (PE) nanoparticle, was encapsulated via water-in-oil-in-water (W/O/W) double emulsion with the solvent evaporation method by one-pot reaction and utilized as a fluorescence turn-on sensor for detecting Fe3+, Cr3+, and Al3+ ions. pyrene 2-8 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 274-277 34114810-0 2021 Liposomal Controlled Release Ag-Activated DNAzyme Cycle Amplification on a 2D Pyrene COF-Based Photocathode for alpha-Synuclein Immunosensing. pyrene 78-84 synuclein alpha Homo sapiens 112-127 34114810-3 2021 Herein, a two-dimensional (2D) pyrene covalent organic framework (COF, PAF-130) is exemplified for the first time as a high-performance photocathode for precise immunosensing of alpha-synuclein (alpha-Syn) by integrating a DNAzyme-induced signal cycle amplification strategy with Ag nanoparticles (NPs)-mediated liposomal immunoassay. pyrene 31-37 synuclein alpha Homo sapiens 178-193 34114810-3 2021 Herein, a two-dimensional (2D) pyrene covalent organic framework (COF, PAF-130) is exemplified for the first time as a high-performance photocathode for precise immunosensing of alpha-synuclein (alpha-Syn) by integrating a DNAzyme-induced signal cycle amplification strategy with Ag nanoparticles (NPs)-mediated liposomal immunoassay. pyrene 31-37 synuclein alpha Homo sapiens 195-204 34221324-0 2021 Cyclophane with eclipsed pyrene units enables construction of spin interfaces with chemical accuracy. pyrene 25-31 spindlin 1 Homo sapiens 62-66 35307418-4 2022 Transcriptomics results showed that exposure to Pyr and 1-Cl-Pyr at 5 and 50 nM obviously altered the gene expression profiles, but did not significantly induce the expression of genes strongly related to the activation of aryl hydrocarbon receptor (AhR), such as CYP1A1, CYP1B1, AHR, ARNT. pyrene 48-51 aryl hydrocarbon receptor Homo sapiens 250-253 35307418-4 2022 Transcriptomics results showed that exposure to Pyr and 1-Cl-Pyr at 5 and 50 nM obviously altered the gene expression profiles, but did not significantly induce the expression of genes strongly related to the activation of aryl hydrocarbon receptor (AhR), such as CYP1A1, CYP1B1, AHR, ARNT. pyrene 48-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 264-270 35307418-4 2022 Transcriptomics results showed that exposure to Pyr and 1-Cl-Pyr at 5 and 50 nM obviously altered the gene expression profiles, but did not significantly induce the expression of genes strongly related to the activation of aryl hydrocarbon receptor (AhR), such as CYP1A1, CYP1B1, AHR, ARNT. pyrene 48-51 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 272-278 35307418-4 2022 Transcriptomics results showed that exposure to Pyr and 1-Cl-Pyr at 5 and 50 nM obviously altered the gene expression profiles, but did not significantly induce the expression of genes strongly related to the activation of aryl hydrocarbon receptor (AhR), such as CYP1A1, CYP1B1, AHR, ARNT. pyrene 48-51 aryl hydrocarbon receptor Homo sapiens 280-283 35307418-4 2022 Transcriptomics results showed that exposure to Pyr and 1-Cl-Pyr at 5 and 50 nM obviously altered the gene expression profiles, but did not significantly induce the expression of genes strongly related to the activation of aryl hydrocarbon receptor (AhR), such as CYP1A1, CYP1B1, AHR, ARNT. pyrene 48-51 aryl hydrocarbon receptor nuclear translocator Homo sapiens 285-289 34343757-4 2021 Furthermore, one sample of O presented a high PAH bioavailability as shown through the BAF, with emphasis on pyrene (BAF = 26.8). pyrene 109-115 BAF nuclear assembly factor 1 Homo sapiens 117-120 34332006-0 2021 Benzo(a)pyrene exposure in utero exacerbates Parkinson"s Disease (PD)-like alpha-synucleinopathy in A53T human alpha-synuclein transgenic mice. pyrene 8-14 synuclein alpha Homo sapiens 111-126 34231284-4 2021 Then, with the aid of pR-/pS-WP5, nanoparticles were formed that exhibited L-/R-handed circularly polarized luminescence with a dissymmetry factor up to +-0.001, arising from pyrene excimers arranged in the chiral manner. pyrene 175-181 transmembrane protein 37 Homo sapiens 22-24 34443404-3 2021 Both the reference triarylborane amino acid and triarylborane-pyrene conjugate bind to BSA and the hDPP III enzyme with high affinities, exhibiting a strong (up to 100-fold) fluorescence increase, whereby the triarylborane-pyrene conjugate additionally retained FRET upon binding to the protein. pyrene 223-229 dipeptidyl peptidase 3 Homo sapiens 99-107 34148513-6 2021 Besides, consortium TC showed tolerances to high concentrations of pyrene (up to 1000 mg/L) and different heavy metal stresses (including Zn2+, Cd2+, and Pb2+). pyrene 67-73 CD2 molecule Homo sapiens 144-147 35583491-1 2022 This work aimed to investigate the interaction of bovine serum albumin with newly synthesized potent new pyrene derivatives (PS1 and PS2), which might prove useful to have a better antibacterial character as found for similar compounds in the previous report (Low et al. pyrene 105-111 albumin Homo sapiens 57-70 35583491-1 2022 This work aimed to investigate the interaction of bovine serum albumin with newly synthesized potent new pyrene derivatives (PS1 and PS2), which might prove useful to have a better antibacterial character as found for similar compounds in the previous report (Low et al. pyrene 105-111 taste 2 receptor member 62 pseudogene Homo sapiens 125-128 35583491-1 2022 This work aimed to investigate the interaction of bovine serum albumin with newly synthesized potent new pyrene derivatives (PS1 and PS2), which might prove useful to have a better antibacterial character as found for similar compounds in the previous report (Low et al. pyrene 105-111 taste 2 receptor member 64 pseudogene Homo sapiens 133-136 35358383-1 2022 Two belt-like expanded carbaporphyrins (NB1 and NB2) were prepared via a one-pot procedure that involves a (6 + 3) condensation between a pyrene-bearing tetrapyrrole precursor (2) and pentafluorobenzaldehyde, followed by oxidation. pyrene 138-144 CD177 molecule Homo sapiens 40-43 35561843-0 2022 MiR-34a-5p/Sirt1 axis: A novel pathway for puerarin-mediated hepatoprotection against benzo(a)pyrene. pyrene 94-100 sirtuin 1 Homo sapiens 11-16 35358383-1 2022 Two belt-like expanded carbaporphyrins (NB1 and NB2) were prepared via a one-pot procedure that involves a (6 + 3) condensation between a pyrene-bearing tetrapyrrole precursor (2) and pentafluorobenzaldehyde, followed by oxidation. pyrene 138-144 contactin 5 Homo sapiens 48-51 35358383-2 2022 Single crystal X-ray diffraction analyses revealed that NB1 and NB2 both contain six dipyrromethene moieties and three bridging pyrene units. pyrene 128-134 CD177 molecule Homo sapiens 56-59 35358383-2 2022 Single crystal X-ray diffraction analyses revealed that NB1 and NB2 both contain six dipyrromethene moieties and three bridging pyrene units. pyrene 128-134 contactin 5 Homo sapiens 64-67 35358383-3 2022 In the structure of NB1, there are two vertically orientated pyrene units and one transverse orientated pyrene unit; however, in NB2 all three pyrene units are vertically orientated. pyrene 61-67 CD177 molecule Homo sapiens 20-23 35358383-3 2022 In the structure of NB1, there are two vertically orientated pyrene units and one transverse orientated pyrene unit; however, in NB2 all three pyrene units are vertically orientated. pyrene 104-110 CD177 molecule Homo sapiens 20-23 35358383-3 2022 In the structure of NB1, there are two vertically orientated pyrene units and one transverse orientated pyrene unit; however, in NB2 all three pyrene units are vertically orientated. pyrene 104-110 contactin 5 Homo sapiens 129-132 35358383-3 2022 In the structure of NB1, there are two vertically orientated pyrene units and one transverse orientated pyrene unit; however, in NB2 all three pyrene units are vertically orientated. pyrene 143-149 CD177 molecule Homo sapiens 20-23 35358383-3 2022 In the structure of NB1, there are two vertically orientated pyrene units and one transverse orientated pyrene unit; however, in NB2 all three pyrene units are vertically orientated. pyrene 143-149 contactin 5 Homo sapiens 129-132 35502548-0 2022 Editor"s Note: Deficiency of NRH: Quinone Oxidoreductase 2 Increases Susceptibility to 7,12-Dimethylbenz(a)anthracene and Benzo(a)pyrene-Induced Skin Carcinogenesis. pyrene 130-136 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 29-58 35257134-6 2022 From fittings of the diffraction profiles using model structures, we have observed that some small clusters adopt the structures of the corresponding solid sample, even for dimers such as iodine and pyrene, while others require trimers or tetramers to reach the structural motif of bulk solids, and smaller clusters such as CS2 dimers adopt gas phase structures. pyrene 199-205 chorionic somatomammotropin hormone 2 Homo sapiens 324-327 35405096-8 2022 Notably, we confirmed that a regulatory axis, PP2A B56alpha-AHR-Cyp1a1 was involved in benzo(a)pyrene-induced cytotoxicity through dephosphorylation of the metabolic nuclear receptor AHR at Ser36. pyrene 95-101 aryl-hydrocarbon receptor Mus musculus 60-63 35405096-8 2022 Notably, we confirmed that a regulatory axis, PP2A B56alpha-AHR-Cyp1a1 was involved in benzo(a)pyrene-induced cytotoxicity through dephosphorylation of the metabolic nuclear receptor AHR at Ser36. pyrene 95-101 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 64-70 35405096-8 2022 Notably, we confirmed that a regulatory axis, PP2A B56alpha-AHR-Cyp1a1 was involved in benzo(a)pyrene-induced cytotoxicity through dephosphorylation of the metabolic nuclear receptor AHR at Ser36. pyrene 95-101 aryl-hydrocarbon receptor Mus musculus 183-186 35396741-4 2022 RESULTS: In this work, The CMC of ZH (0.535 mg mL-1 ) was obtained by pyrene fluorescent probe method. pyrene 70-76 L1 cell adhesion molecule Mus musculus 47-51 35344733-0 2022 Establishment of cytochrome P450 1a gene-knockout Javanese medaka, Oryzias javanicus, which distinguishes toxicity modes of the polycyclic aromatic hydrocarbons, pyrene and phenanthrene. pyrene 162-168 cytochrome P450 1A1 Oryzias latipes 17-35 35344733-5 2022 Compared to WT, KO fish were more sensitive to pyrene, suggesting that Cyp1a transforms pyrene into less toxic metabolites. pyrene 47-53 cytochrome P450 1A1 Oryzias latipes 71-76 35344733-5 2022 Compared to WT, KO fish were more sensitive to pyrene, suggesting that Cyp1a transforms pyrene into less toxic metabolites. pyrene 88-94 cytochrome P450 1A1 Oryzias latipes 71-76 35481410-0 2022 Interactions between Benzo(a)pyrene exposure and genetic polymorphisms of AhR signaling pathway on missed abortion. pyrene 29-35 aryl hydrocarbon receptor Homo sapiens 74-77 35235235-2 2022 The bridging ligands are laterally pi-extended by anellating a pyrene (Ru2 -7, Ru2 -8) or a 6,7-benzoquinoxaline (Ru2 -3, Ru2 -4) pi-perimeter. pyrene 63-69 doublecortin domain containing 2 Homo sapiens 71-77 35235235-2 2022 The bridging ligands are laterally pi-extended by anellating a pyrene (Ru2 -7, Ru2 -8) or a 6,7-benzoquinoxaline (Ru2 -3, Ru2 -4) pi-perimeter. pyrene 63-69 doublecortin domain containing 2 Homo sapiens 79-85 2742872-9 1989 Measurement of the transport of cholesterol and of oxysterol derivatives by the monolayer-vesicles assay and of a series of pyrene-labeled phosphatidylcholine species by the fluorescent transfer assay showed a high correlation between the spontaneous and the nsLTP-mediated lipid transport. pyrene 124-130 sterol carrier protein 2 Homo sapiens 259-264 35011557-1 2022 Pyrene molecules containing NBN-doped polycyclic aromatic hydrocarbons (PAHs) have been synthesized by a simple and efficient intermolecular dehydration reaction between 1-pyrenylboronic acid and aromatic diamine. pyrene 0-6 nibrin Homo sapiens 28-31 35194628-1 2022 Herein, we discuss a new pyrene-based push-pull dye (PC) and our investigation of its photophysical properties and applicability to biological studies. pyrene 25-31 pyruvate carboxylase Homo sapiens 53-55 2799823-1 1989 m-Xylene (1 g/kg, i.p., 1 h) was shown to decrease aryl hydrocarbon hydroxylase (AHH) activity, a detoxification pathway for benzo[a]pyrene (BaP), in the rat lung. pyrene 133-139 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 51-79 2799823-1 1989 m-Xylene (1 g/kg, i.p., 1 h) was shown to decrease aryl hydrocarbon hydroxylase (AHH) activity, a detoxification pathway for benzo[a]pyrene (BaP), in the rat lung. pyrene 133-139 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 81-84 35011557-0 2022 Unpredicted Concentration-Dependent Sensory Properties of Pyrene-Containing NBN-Doped Polycyclic Aromatic Hydrocarbons. pyrene 58-64 nibrin Homo sapiens 76-79 2559107-5 1989 BHK gelsolin nucleates the polymerization of pyrene-labelled G-actin in a Ca2+-dependent manner. pyrene 45-51 GSN Sus scrofa 4-12 2479062-1 1989 Previous studies have shown that dietary calcium glucarate, an inhibitor of beta-glucuronidase, is a potent inhibitor of promotion of diethylnitrosamine-induced altered hepatic foci, 7,12-dimethylbenzanthracene-induced mammary tumorigenesis and benzo(a)pyrene-induced lung carcinogenesis. pyrene 253-259 glucuronidase, beta Rattus norvegicus 76-94 2910310-7 1989 The rate of aniline hydroxylation catalyzed by P-450-D3 was similar to that catalyzed by P-450c which is a low spin form of cytochrome P-450 purified from liver microsomes of PCB-treated rats, whereas the catalytic activities of P-450-D3 for 7-ethoxycoumarin O-deethylation and benzo(a)pyrene hydroxylation were considerably lower than those of P-450c. pyrene 286-292 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 89-95 2753044-4 1989 The hexapeptides, DIKKKL and DAIKKL, also inhibited the binding of cofilin to F-actin and affected the fluorescence intensity of pyrene-labeled F-actin and the rate of actin polymerization, like the heptapeptide. pyrene 129-135 cofilin 1 Homo sapiens 67-74 2711409-1 1989 Coal-derived complex organic mixtures [COM] with boiling points greater than or equal to 370 degrees C (greater than or equal to 700 degrees F) are known to inhibit both mouse skin tumor initiation by benzo[a]pyrene [BAP], and BAP-induced bacterial mutagenesis. pyrene 209-215 prohibitin 2 Mus musculus 217-220 2564282-0 1989 Synthesis of pyrene derivatives of cerebroside sulfate and their use for determining arylsulfatase A activity. pyrene 13-19 arylsulfatase A Homo sapiens 85-100 2642389-1 1989 Cytoskeletons of detergent-extracted quiescent macrophages have nucleation sites that increase the rate of pyrene-labeled actin assembly in vitro. pyrene 107-113 actin Oryctolagus cuniculus 122-127 2642389-2 1989 Cytochalasin D, which inhibits actin assembly at the fast-exchanging ends of filaments (barbed with respect to heavy meromyosin decorated filaments), only partially inhibits the increased assembly rate, demonstrating that pyrene-actin monomers add to both ends of filaments present in the cytoskeletons. pyrene 222-228 actin Oryctolagus cuniculus 229-234 2654935-4 1989 In contrast, 100% of the mutations in the Ki-ras gene detected in methylnitrosourea-induced lung tumors and 93% of the mutations in the Ki-ras genes detected in benzo[a]pyrene-induced lung tumors were in codon 12, whereas 90% of the mutations in the Ki-ras genes detected in ethyl carbamate-induced lung tumors were in codon 61. pyrene 169-175 Kirsten rat sarcoma viral oncogene homolog Mus musculus 136-142 2654935-4 1989 In contrast, 100% of the mutations in the Ki-ras gene detected in methylnitrosourea-induced lung tumors and 93% of the mutations in the Ki-ras genes detected in benzo[a]pyrene-induced lung tumors were in codon 12, whereas 90% of the mutations in the Ki-ras genes detected in ethyl carbamate-induced lung tumors were in codon 61. pyrene 169-175 Kirsten rat sarcoma viral oncogene homolog Mus musculus 136-142 2742139-0 1989 A sensitive and continuous fluorometric assay for phospholipase A2 using pyrene-labeled phospholipids in the presence of serum albumin. pyrene 73-79 phospholipase A2 group IB Homo sapiens 50-66 3190247-4 1988 Furthermore, labeling of isolated beta or gamma chains in denaturant, followed by reconstitution, gave separate samples of beta beta- and gamma gamma-tropomyosin that exhibited even greater pyrene excimer to monomer emission ratios. pyrene 190-196 tropomyosin 2 Gallus gallus 128-161 2843287-0 1988 Interaction of S-100b protein with cardiolipin vesicles as monitored by electron spin resonance, pyrene fluorescence and circular dichroism. pyrene 97-103 S100 calcium binding protein B Homo sapiens 15-21 3242591-6 1988 Tropomyosin induced a change in the fluorescence spectrum of pyrene-caldesmon, indicating a conformational change associated with the interaction between caldesmon and tropomyosin. pyrene 61-67 caldesmon 1 Homo sapiens 154-163 3242591-10 1988 The addition of tropomyosin also changed the fluorescence spectrum of pyrene-caldesmon bound to actin filaments. pyrene 70-76 caldesmon 1 Homo sapiens 77-86 3242591-11 1988 The change in the conformation of tropomyosin, caused by the interaction between caldesmon and tropomyosin, was studied with pyrene-labeled tropomyosin. pyrene 125-131 caldesmon 1 Homo sapiens 81-90 3178719-1 1988 Aqueous dispersions of 12-(1-pyrene)-dodecanoic acid (P12), a medium-chain fatty acid to which the fluorescent probe pyrene has been covalently linked, shows a considerable increase in fluorescence when the probe is introduced into a hydrophobic environment. pyrene 29-35 DNA polymerase epsilon 4, accessory subunit Homo sapiens 54-57 3178719-6 1988 The yellow trinitrophenyl (TNP) residues, which were thereby covalently linked to the albumin, quenched the fluorescence of pyrene in the TNP-albumin/P12 complex. pyrene 124-130 DNA polymerase epsilon 4, accessory subunit Homo sapiens 150-153 3242591-2 1988 The number of sulfhydryl (SH) groups in caldesmon was around 3.5 on the basis of reactivity to 5,5"-dithiobis(2-nitrobenzoate); 80% of the SH groups were labeled with pyrene. pyrene 167-173 caldesmon 1 Homo sapiens 40-49 3242591-3 1988 The fluorescence spectrum from pyrene-caldesmon showed the presence of excited monomer and dimer (excimer). pyrene 31-37 caldesmon 1 Homo sapiens 38-47 3242591-5 1988 The labeling of caldesmon with pyrene did not affect its ability to inhibit actin activation of heavy meromyosin Mg-ATPase and the release of this inhibition in the presence of Ca2+-calmodulin. pyrene 31-37 caldesmon 1 Homo sapiens 16-25 3242591-6 1988 Tropomyosin induced a change in the fluorescence spectrum of pyrene-caldesmon, indicating a conformational change associated with the interaction between caldesmon and tropomyosin. pyrene 61-67 caldesmon 1 Homo sapiens 68-77 3166380-1 1988 Pyrene dodecanoic acid (P12), a medium-chain fatty acid to which the fluorescent probe pyrene is covalently linked, showed a considerable increase in fluorescence when the probe was introduced into a hydrophobic environment. pyrene 87-93 DNA polymerase epsilon 4, accessory subunit Homo sapiens 24-27 2843287-1 1988 The interaction of S-100b protein with cardiolipin (CL) vesicles has been studied by electron spin resonance, pyrene fluorescence, and circular dichroism. pyrene 110-116 S100 calcium binding protein B Homo sapiens 19-25 2843287-2 1988 Electron spin resonance and pyrene fluorescence data indicate that S-100b binds to the polar surface of vesicles Ca2+-independently. pyrene 28-34 S100 calcium binding protein B Homo sapiens 67-73 2843287-3 1988 In the presence of Ca2+, S-100b potentiates the Ca2+-induced clustering of the polar headgroups of CL molecules and causes a further reduction in the Ca2+-dependent decrease in the lateral mobility of the pyrene inserted into the lipid bilayer, which points to an effect of the protein on the hydrophobic core of the lipid bilayer through a larger perturbation of its polar surface. pyrene 205-211 S100 calcium binding protein B Homo sapiens 25-31 3400190-2 1988 The cholesterol-acceptory function was estimated as follows: by incorporation of fluorescent probes (cholestatriene and pyrene) into particles of HDL3, by elimination of cholesterol from erythrocyte membranes and by increase of the lipoproteins size evaluated using the method of quazi-resilient dispersion of laser light. pyrene 120-126 HDL3 Homo sapiens 146-150 3389515-2 1988 Upon phospholipase A2 catalyzed hydrolysis of this molecule pyrene monomer fluorescence emission intensity increased as a result of the transfer of the pyrene fatty acid to the aqueous phase. pyrene 60-66 phospholipase A2 group IB Homo sapiens 5-21 3389515-9 1988 The hydrolysis of DMPC-PPHTE vesicles was measured by following the increase in pyrene monomer fluorescence emission due to phospholipase A2 action on PPHTE. pyrene 80-86 phospholipase A2 group IB Homo sapiens 124-140 3345843-3 1988 Changes in the pyrene excimer/monomer fluorescence emission intensity ratio coincide with the enhancement of phospholipase A2 activity at the critical micellar concentration. pyrene 15-21 phospholipase A2 group IB Homo sapiens 109-125 3389515-0 1988 Phospholipase A2 assay using an intramolecularly quenched pyrene-labeled phospholipid analog as a substrate. pyrene 58-64 phospholipase A2 group IB Homo sapiens 0-16 3038173-0 1987 Binding of cytochrome c to liposomes as revealed by the quenching of fluorescence from pyrene-labeled phospholipids. pyrene 87-93 cytochrome c, somatic Homo sapiens 11-23 3335509-3 1988 Mitochondrial cytochrome P-450 was partially purified and reconstituted in vitro using adrenodoxin and the adrenodoxin reductase electron transfer system and [3H]benzo(a)pyrene as the substrate. pyrene 170-176 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 14-30 2832441-1 1987 Activation of skeletal muscle myosin and myosin subfragment-1 (S1) by actin purified from the cytoplasm of cultured BHK cells was studied using the fluorescence of pyrene-labelled BHK F-actin and its quenching by S1 and by an enzyme-linked ATPase assay. pyrene 164-170 actin alpha 2, smooth muscle Sus scrofa 70-75 3676314-2 1987 By treatment of the membranes with neuraminidase, the fluorescence parameters of pyrene-labeled membranes changed; i.e., a shift of thermal transition temperature, an increase in the fluorescence quenching rate for Tl+ and a decrease in the fluorescence lifetime. pyrene 81-87 neuraminidase 1 Homo sapiens 35-48 3676320-3 1987 Under approximately physiological ionic conditions (0.1 M NaCl) addition of two HMG2 molecules per nucleosome, labeled by N-(3-pyrene)maleimide at the sulfhydryl groups of Cys-110 of histones H3, resulted in a decrease of the pyrene excimer fluorescence corresponding to the slight movement of the sulfhydryl groups of the two histone H3 molecules apart. pyrene 127-133 high mobility group protein B2 Bos taurus 80-84 3038173-3 1987 Binding of cyt c to liposomes was monitored by measuring the decrease either in the fluorescence intensity or in the lifetime of pyrene emission. pyrene 129-135 cytochrome c, somatic Homo sapiens 11-16 3824871-10 1987 Significant changes in the serum AST, SDH and LDH levels were observed with the nitrated products of pyrene at 24 hr. pyrene 101-107 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 33-36 3493777-4 1987 In contrast, the content of P-450 HFLa was highly correlated with the activity of benzo(a)pyrene hydroxylation, 7-ethoxycoumarin O-deethylation or testosterone 6 beta-hydroxylation. pyrene 90-96 cytochrome P450 family 3 subfamily A member 7 Homo sapiens 28-38 3805044-2 1987 Pyrene-labeled thioesterase II does not exhibit increased fluorescence anisotropy when mixed with fatty acid synthetase, suggesting that the enzymes do not readily form a complex. pyrene 0-6 oleoyl-ACP hydrolase Rattus norvegicus 15-30 3824871-10 1987 Significant changes in the serum AST, SDH and LDH levels were observed with the nitrated products of pyrene at 24 hr. pyrene 101-107 sorbitol dehydrogenase Rattus norvegicus 38-41 3824871-11 1987 Only SDH levels were significantly different when pyrene and its nitrated products were compared. pyrene 50-56 sorbitol dehydrogenase Rattus norvegicus 5-8 2430627-4 1986 Dynamic quenching of the conjugated pyrene moiety by acrylamide, and iodide ions is markedly reduced upon reaction of the protease with alpha 2-macroglobulin, indicating a reduced accessibility of the protease active center in the complex. pyrene 36-42 alpha-2-macroglobulin Homo sapiens 136-157 3569016-0 1987 Chemoprevention by antineoplaston A10 of benzo(a)pyrene-induced pulmonary neoplasia. pyrene 49-55 UDP glucuronosyltransferase 1 family, polypeptide A7C Mus musculus 34-37 3038665-0 1987 Action of xanthine-xanthine oxidase system on microsomal benzo(a)pyrene metabolism in vitro. pyrene 65-71 xanthine dehydrogenase Mus musculus 19-35 3753005-8 1986 Both cytochromes P-450A and P-450B were distinct from the major benzo[a]pyrene hydroxylating form, cytochrome P-450E, by the criteria of spectroscopic properties, substrate profiles, minimum molecular weights on NaDodSO4-polyacrylamide gels, peptide mapping and lack of cross-reaction with antibody raised against cytochrome P-450E. pyrene 72-78 cytochrome P450, family 2, subfamily b, polypeptide 2 Rattus norvegicus 99-116 2430627-5 1986 Singlet--singlet energy transfer measurements from the donor pyrene labeled active center of the proteases to the alpha 2-macroglobulin acceptor labeled thiol groups which are liberated upon protease fixation, gave a rough estimate of the distance (about 25 A) between the active center of the two alpha 2-macroglobulin bound protease molecules. pyrene 61-67 alpha-2-macroglobulin Homo sapiens 114-135 2430627-5 1986 Singlet--singlet energy transfer measurements from the donor pyrene labeled active center of the proteases to the alpha 2-macroglobulin acceptor labeled thiol groups which are liberated upon protease fixation, gave a rough estimate of the distance (about 25 A) between the active center of the two alpha 2-macroglobulin bound protease molecules. pyrene 61-67 alpha-2-macroglobulin Homo sapiens 298-319 3462004-3 1986 Because of the intense fluorescence of the pyrene ring, the association of P12 with intact cells could be analysed using a fluorescence microscope or a fluorescence-activated cell sorter (FACS), and the incorporation of P12 into cellular lipids could be quantified, following their extraction in a spectrofluorimeter. pyrene 43-49 polymerase (DNA-directed), delta 4 Mus musculus 75-78 2860738-10 1985 Although pyrene caused a small but significant increase in the serum AST and bilirubin levels 24 hr after treatment, no significant change in the serum AST, ALT, GGTP, BUN, and creatine levels were observed with the ozonized products of pyrene at 24 or 72 hr. pyrene 9-15 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 69-72 4091793-0 1985 Pressure-relaxation studies of pyrene-labelled actin and myosin subfragment 1 from rabbit skeletal muscle. pyrene 31-37 actin Oryctolagus cuniculus 47-52 4085087-3 1985 The regulation of human plasma lecithin:cholesterol acyltransferase (LCAT) by changes in bilayer fluidity of substrate egg phosphatidylcholine (egg PC) unilamellar vesicles was investigated using pyrene excimer fluorescence to measure fluidity. pyrene 196-202 lecithin-cholesterol acyltransferase Homo sapiens 31-67 4085087-3 1985 The regulation of human plasma lecithin:cholesterol acyltransferase (LCAT) by changes in bilayer fluidity of substrate egg phosphatidylcholine (egg PC) unilamellar vesicles was investigated using pyrene excimer fluorescence to measure fluidity. pyrene 196-202 lecithin-cholesterol acyltransferase Homo sapiens 69-73 4016732-3 1985 TAOc1BPrc1 had intermediate benzo(a)pyrene-metabolizing activity, depending on cell density and incubation time. pyrene 36-42 protein regulator of cytokinesis 1 Mus musculus 0-10 4008500-5 1985 In a low ionic strength buffer the absence of filaments was confirmed by electron microscopy, ultracentrifugation, and the fluorescence of pyrene-labeled actin. pyrene 139-145 actin Oryctolagus cuniculus 154-159 3707614-7 1986 These results suggest that CsA has the potential to cause drug interactions involving inhibition of drug biotransformation, particularly of drugs that are metabolised by the same types of cytochrome P-450 which oxidise benzo[a]pyrene and theophylline. pyrene 227-233 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 188-204 3948999-3 1986 8-Anilino-1-naphthalenesulfonate fluorescence, pyrene excimer fluorescence and diphenylhexatriene fluorescence polarisation studies indicate that seminalplasmin binds to the spermatozoal membranes, and leads to an increase in the fluidity of both the plasma and the acrosomal membranes. pyrene 47-53 caltrin Bos taurus 146-160 3936545-9 1985 In a model HDL composed of DMPC and apoA-I, the lateral diffusion of a pyrene-labeled cholesterol was dramatically changed at the Tc whereas little change was observed in that of a pyrene-labeled PC. pyrene 71-77 apolipoprotein A1 Homo sapiens 36-42 3936545-9 1985 In a model HDL composed of DMPC and apoA-I, the lateral diffusion of a pyrene-labeled cholesterol was dramatically changed at the Tc whereas little change was observed in that of a pyrene-labeled PC. pyrene 181-187 apolipoprotein A1 Homo sapiens 36-42 3911945-1 1985 A pyrene label attached to Cys-374 of actin has been shown to be a useful probe for monitoring the interaction of actin with myosin subfragments [Kouyama & Mihashi (1981) Eur. pyrene 2-8 myosin heavy chain 14 Homo sapiens 125-131 4016106-2 1985 The regulation of lecithin:cholesterol acyltransferase by changes in phospholipid bilayer fluidity was investigated using pyrene excimer fluorescence to measure fluidity. pyrene 122-128 lecithin-cholesterol acyltransferase Homo sapiens 18-54 3873942-1 1985 The inducibility of skin and liver microsomal cytochrome P-450 dependent aryl hydrocarbon hydroxylase and other monooxygenases by a mixture of nitropyrenes was assessed and compared with the parent non-nitrated compound, pyrene. pyrene 148-154 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 46-62 3928617-8 1985 The most efficient catalysts were as follows: P-448 L and P-451 II for benzo[a]pyrene 3-hydroxylation; P-448 L for 7-ethoxycoumarin O-deethylation; P-448 L, P-451 II, and P-448 H for biphenyl 4-hydroxylation; P-448 L and P-448 H for biphenyl 2-hydroxylation; and P-451 II and P-448 H for estradiol 2-hydroxylation. pyrene 79-85 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 46-51 2989797-4 1985 We show in this report, however, that human inducible P1-450 mRNA concentrations are very highly correlated (r = 0.98; N = 6) with genetic differences in benzo[a]pyrene metabolism in mitogen-activated lymphocyte cultures. pyrene 162-168 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 54-60 3873942-1 1985 The inducibility of skin and liver microsomal cytochrome P-450 dependent aryl hydrocarbon hydroxylase and other monooxygenases by a mixture of nitropyrenes was assessed and compared with the parent non-nitrated compound, pyrene. pyrene 148-154 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 73-101 3919010-10 1985 The distance between the pyrene at the thioesterase active site and the coumarin attached to pantetheine thiol on the same subunit of fatty acid synthase was estimated from the efficiency of energy transfer to be 37 A. pyrene 25-31 fatty acid synthase Homo sapiens 134-153 3158348-0 1985 Interactions of pyrene derivatives with lipid bilayers and with (Ca2+-Mg2+)-ATPase. pyrene 16-22 plasma membrane calcium-transporting ATPase 1 Oryctolagus cuniculus 65-82 3158348-1 1985 The intensities of fluorescence emission for pyrene and a number of its derivatives increase on binding to lipid bilayers and to the (Ca2+-Mg2+)-ATPase purified from rabbit muscle sarcoplasmic reticulum. pyrene 45-51 plasma membrane calcium-transporting ATPase 1 Oryctolagus cuniculus 134-151 4015664-2 1985 Benzo(a)pyrene exposure at 2.0 mg dose only elevated the level of cytochrome P-450 and b5, and activity of benzopyrene hydroxylase in liver, and extent of increase was similar in normal and vitamin A deficient groups. pyrene 8-14 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 66-89 3882722-6 1985 Band 4.9 increases the length of the lag phase and decreases the rate of elongation during actin polymerization as measured by high-shear Ostwald viscometry or by the increase in the fluorescence of pyrene-labeled actin. pyrene 199-205 actin Oryctolagus cuniculus 214-219 3965454-0 1985 Troponin-C-mediated calcium-sensitive changes in the conformation of troponin I detected by pyrene excimer fluorescence. pyrene 92-98 troponin I, fast skeletal muscle Oryctolagus cuniculus 69-79 3968077-2 1985 Treatment of S-acyl fatty acid synthase thioester hydrolase from the uropygial gland of Peking duck with pyrenebutylmethanephosphonofluoridate resulted in inactivation of the enzyme with covalent attachment of the pyrene derivative to the enzyme. pyrene 105-111 fatty acid synthase Anas platyrhynchos 20-39 3968077-4 1985 When avian fatty acid synthase was added to the modified thioesterase, the fluorescence anisotropy of the pyrene derivative increased dramatically. pyrene 106-112 fatty acid synthase Anas platyrhynchos 11-30 3968077-8 1985 These results show that fluorescence anisotropy of the pyrene derivative attached to the thioesterase can be used to directly measure the binding of this enzyme to fatty acid synthase. pyrene 55-61 fatty acid synthase Anas platyrhynchos 164-183 3965454-2 1985 The fluorescence spectra of pyrene-labeled TnI (pyr-TnI) exhibit peaks characteristic of pyrene in its monomeric form and an additional peak resulting from formation of excited dimers (excimers), indicating that the labeled cysteines are close together. pyrene 28-34 troponin I, fast skeletal muscle Oryctolagus cuniculus 43-46 3965454-2 1985 The fluorescence spectra of pyrene-labeled TnI (pyr-TnI) exhibit peaks characteristic of pyrene in its monomeric form and an additional peak resulting from formation of excited dimers (excimers), indicating that the labeled cysteines are close together. pyrene 28-34 troponin I, fast skeletal muscle Oryctolagus cuniculus 52-55 3965454-2 1985 The fluorescence spectra of pyrene-labeled TnI (pyr-TnI) exhibit peaks characteristic of pyrene in its monomeric form and an additional peak resulting from formation of excited dimers (excimers), indicating that the labeled cysteines are close together. pyrene 89-95 troponin I, fast skeletal muscle Oryctolagus cuniculus 43-46 3965454-2 1985 The fluorescence spectra of pyrene-labeled TnI (pyr-TnI) exhibit peaks characteristic of pyrene in its monomeric form and an additional peak resulting from formation of excited dimers (excimers), indicating that the labeled cysteines are close together. pyrene 89-95 troponin I, fast skeletal muscle Oryctolagus cuniculus 52-55 6480587-6 1984 Using pyrene-labeled actin, we show that brevin binds 2 mol of monomeric actin. pyrene 6-12 gelsolin Homo sapiens 41-47 6509022-2 1984 Upon binding of cofilin, the fluorescence of pyrene-labeled actin under polymerizing conditions is changed into the monomer form, irrespective of whether cofilin is added to actin before or after polymerization. pyrene 45-51 cofilin 1 Homo sapiens 16-23 6089810-2 1983 This study reports changes in Glyoxalase I activity in relation to DNA synthesis in regenerating liver treated with two polycyclic aromatic hydrocarbons - 7,12-dimethylbenz (a) anthracene and benzo(a)pyrene. pyrene 200-206 glyoxalase 1 Mus musculus 30-42 6696918-1 1984 Derivatives of human thrombin and antithrombin III with fluorescent labels covalently attached to their carbohydrate moieties were prepared by reaction of periodate-oxidized proteins with amino derivatives of dansyl, fluorescein and pyrene. pyrene 233-239 coagulation factor II, thrombin Homo sapiens 21-29 6696918-1 1984 Derivatives of human thrombin and antithrombin III with fluorescent labels covalently attached to their carbohydrate moieties were prepared by reaction of periodate-oxidized proteins with amino derivatives of dansyl, fluorescein and pyrene. pyrene 233-239 serpin family C member 1 Homo sapiens 34-50 6640814-5 1983 The hydrolysis of C30PHPC by human pancreatic phospholipase A2 was followed by monitoring the increase in the pyrene monomer fluorescence emission intensity occurring as a consequence of transfer of the reaction product, pyren-1-yl hexanoic acid into the aqueous phase. pyrene 110-116 phospholipase A2 group IB Homo sapiens 46-62 6321048-0 1984 Quantitative significance of glutathione and glutathione-S-transferase in regulating benzo[a]pyrene anti diol-epoxide level in reconstituted C3H/10T1/2 cell lysates, and comparison to rat liver. pyrene 93-99 hematopoietic prostaglandin D synthase Mus musculus 45-70 6326393-11 1984 A reconstituted system of purified cytochrome P-448, purified NADPH-cytochrome P-450 (c) reductase and phospholipid showed aryl hydrocarbon hydroxylase activity towards benzo[a]pyrene. pyrene 177-183 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 35-51 6326393-11 1984 A reconstituted system of purified cytochrome P-448, purified NADPH-cytochrome P-450 (c) reductase and phospholipid showed aryl hydrocarbon hydroxylase activity towards benzo[a]pyrene. pyrene 177-183 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 68-84 6640434-2 1983 3-Methylcholanthrene (3-MC) and pregnenolone-16 alpha-carbonitrile (PCN), known to induce different forms of cytochrome P-450, when administered together increased benzo[a]pyrene oxidation to the same level as observed following 3-MC treatment alone. pyrene 172-178 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 109-125 6832094-6 1983 A high spin form of cytochrome P-450, isolated from the liver of PCB-treated rats, showed very high activity in N-hydroxylation of Trp-P-2, Glu-P-1 and 2-aminofluorene, although its activity was very low in benzo(a)pyrene hydroxylation. pyrene 215-221 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 20-36 6871180-0 1983 Fluorescent properties of pyrene bound at specific acylation sites of chicken liver fatty acid synthase. pyrene 26-32 fatty acid synthase Gallus gallus 84-103 6832094-6 1983 A high spin form of cytochrome P-450, isolated from the liver of PCB-treated rats, showed very high activity in N-hydroxylation of Trp-P-2, Glu-P-1 and 2-aminofluorene, although its activity was very low in benzo(a)pyrene hydroxylation. pyrene 215-221 pyruvate carboxylase Rattus norvegicus 65-68 7316183-0 1981 Continuous fluorometric assay of phospholipase A2 with pyrene-labeled lecithin as a substrate. pyrene 55-61 phospholipase A2 group IB Homo sapiens 33-49 6813677-12 1982 The monoclonal antibody P-450LM4 complexes interacted with protein A, and the enzyme activity for benzo[a]pyrene hydroxylation could be removed by centrifugation. pyrene 106-112 cytochrome P450 1A2 Oryctolagus cuniculus 24-32 7090418-7 1982 Pretreatment with phenobarbital or polychlorinated biphenyls favours oxidation at the K-region, whereas cytochrome P-448 inducers stimulate oxidation at the non-K-region of pyrene. pyrene 173-179 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 104-120 6222551-10 1982 Pyrene excimers are observed at label concentrations larger than 1 mol label per 2.5 mol ATPase. pyrene 0-6 dynein axonemal heavy chain 8 Homo sapiens 89-95 6222551-13 1982 From the fact that non-solubilizing amounts of myristoylglycerophosphocholine strongly reduced the amount of pyrene excimers it is concluded that in the native sarcoplasmic reticulum vesicles at least two ATPase molecules must be in close contact. pyrene 109-115 dynein axonemal heavy chain 8 Homo sapiens 205-211 902255-0 1977 Relationship of aryl hydrocarbon hydroxylase activity to benzo(a)pyrene-metabolizing activity of cells in culture. pyrene 65-71 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 16-44 7336952-3 1981 Cytochrome P-450LM2 was most active in n-hexane and benzo(a)pyrene oxygenation especially with regard to the formation of 2-hexanol, B(a)P-4,5-dihydrodiol and B(a)P-phenol metabolites. pyrene 60-66 cytochrome P450 2B4 Oryctolagus cuniculus 0-19 6105134-4 1980 The numbers of gamma-GT-positive foci induced by B(as)P, 7,12-DMBA, 3-MC and DB (a,h)A were significantly different from all of the parent compounds, anthracene, naphthalene, pyrene and phenanthrene. pyrene 175-181 inactive glutathione hydrolase 2 Homo sapiens 15-23 221020-1 1979 Spin probes differing in the position of their paramagnetic centre are used to quench the fluorescence of pyrene derivatives and chlorophylls incorporated into dimyristoyl phosphatidylcholine membranes. pyrene 106-112 spindlin 1 Homo sapiens 0-4 719813-1 1978 In a Namru mouse liver epithelial cell strain designated NMuLi, aryl hydrocarbon hydroxylase (AHH) activity peaked at 12 h post-induction with 1 microgram/ml of benzo(a)pyrene (BaP) in both confluent and growing cells. pyrene 169-175 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 64-92 719813-1 1978 In a Namru mouse liver epithelial cell strain designated NMuLi, aryl hydrocarbon hydroxylase (AHH) activity peaked at 12 h post-induction with 1 microgram/ml of benzo(a)pyrene (BaP) in both confluent and growing cells. pyrene 169-175 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 94-97 140201-2 1976 Addition of ATP to PM-myosin produces a reversible decrease of 10% in fluorescence intensity of the pyrene fluorophore in the presence of actin. pyrene 100-106 myosin heavy chain 14 Homo sapiens 22-28 182205-2 1976 The sharp gel-liquid crystalline transition usually observed at 23 C in DMPC is both broadened and elevated when ApoC-III is bound as determined (a) from measurements of microscopic viscosity by pyrene excimer fluorescence, (b) from the distribution of di-tert-butyl nitroxide between the bulk aqueous phase and the fluid lipid phase, and (c) from the motion of fatty acyl chains of spin-labeled phosphatdylcholine. pyrene 196-202 apolipoprotein C3 Homo sapiens 114-122 10260-0 1976 Prevention of benzo(a)pyrene-induced mutagenicity by homogeneous epoxide hydratase. pyrene 22-28 epoxide hydrolase 2 Homo sapiens 65-82 33650582-1 2021 In this work, the simple modification of a pyrene group on the labile ligand gives the resultant complex 1 versatility, for example, "turn-on" fluorescence after photo-dissociation, dual PDT and PACT activity, and a large two-photon absorption cross section. pyrene 43-49 RB binding protein 6, ubiquitin ligase Homo sapiens 195-199 167012-4 1975 The ratio IE/IM is proportional to c/eta, where c is the microscopic concentration of the pyrene confined to the hydrocarbon region of the lipoprotein and eta is the microviscosity of that region. pyrene 90-96 endothelin receptor type A Homo sapiens 37-40 5592033-0 1967 [Interaction of pyrene and 3,4-benzpyrene with human serum albumin]. pyrene 16-22 albumin Homo sapiens 59-66 33887907-1 2021 Pyrene linked to two beta-CD (CD = cyclodextrin; PY = pyrene) molecules (CD-PY-CD) and methylviologen (MV2+) linked to two adamantane (AD) groups (AD-MV2+-AD) self-assembled in water to give toroidal nanostructures. pyrene 0-6 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 21-28 33844918-3 2021 Herein, we synthesized three achiral pyrene derivatives, but only the chiral co-assembly (R/S-NMe2-Py-2) can exhibit the regular and orderly helical nanofiber via pi-pi stacking interaction between chiral N,N"-dimethyl-binaphthyldiamine enantiomers (R/S-NMe2) and the achiral pyrene derivative (Py-2). pyrene 37-43 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 94-98 33844918-3 2021 Herein, we synthesized three achiral pyrene derivatives, but only the chiral co-assembly (R/S-NMe2-Py-2) can exhibit the regular and orderly helical nanofiber via pi-pi stacking interaction between chiral N,N"-dimethyl-binaphthyldiamine enantiomers (R/S-NMe2) and the achiral pyrene derivative (Py-2). pyrene 37-43 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 254-258 33844918-3 2021 Herein, we synthesized three achiral pyrene derivatives, but only the chiral co-assembly (R/S-NMe2-Py-2) can exhibit the regular and orderly helical nanofiber via pi-pi stacking interaction between chiral N,N"-dimethyl-binaphthyldiamine enantiomers (R/S-NMe2) and the achiral pyrene derivative (Py-2). pyrene 276-282 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 94-98 33844918-4 2021 Interestingly, this kind of 2:1 molar ratio (R/S-NMe2)2-Py-2 co-assembly with a helical nanofiber structure can emit a strong deep blue CPL signal from the achiral pyrene-based emitter, and the dissymmetry factor gem value can reach 0.027 (lambdaem = 423 nm) in the film from spin-coating. pyrene 164-170 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 49-53 1060073-3 1975 The total benzo[a]pyrene oxygenation rate was greatest for P-450LM1,7, intermediate for P-450LM2, and least for P-450LM4. pyrene 18-24 cytochrome P450 2B4 Oryctolagus cuniculus 88-96 1060073-3 1975 The total benzo[a]pyrene oxygenation rate was greatest for P-450LM1,7, intermediate for P-450LM2, and least for P-450LM4. pyrene 18-24 cytochrome P450 1A2 Oryctolagus cuniculus 112-120 6023575-0 1967 Fluorescence depolarization measurements on pyrene butyric-bovine serum albumin conjugates. pyrene 44-50 albumin Homo sapiens 66-79 33611147-0 2021 Selective anions mediated fluorescence "turn-on", aggregation induced emission (AIE) and lysozyme targeting properties of pyrene-naphthalene sulphonyl conjugate. pyrene 122-128 lysozyme Homo sapiens 89-97 33624653-5 2021 PSP-D and PSP-H have pyrene monomers and linkages of beta-glycosides in their structures, and PSP-S has furanoside in the molecular structure. pyrene 21-27 surfactant protein D Rattus norvegicus 0-5 33624653-5 2021 PSP-D and PSP-H have pyrene monomers and linkages of beta-glycosides in their structures, and PSP-S has furanoside in the molecular structure. pyrene 21-27 phosphoserine phosphatase Rattus norvegicus 10-15 33369044-0 2021 Twist-bend nematic glasses: the synthesis and characterisation of pyrene-based nonsymmetric dimers. pyrene 66-72 twist family bHLH transcription factor 1 Homo sapiens 0-5 33444627-0 2021 Analysis of pyrene-labelled apolipoprotein A-I oligomerization in solution: Spectra deconvolution and changes in P-value and excimer formation. pyrene 12-18 apolipoprotein A1 Homo sapiens 28-46 33170551-5 2021 When achiral anthracene or pyrene was dissolved in Nap2, the pi-liquid could serve as chirality and energy transfer media that both CD and CPL emerged from the achiral anthracene. pyrene 27-33 napsin B aspartic peptidase, pseudogene Homo sapiens 51-55 33044785-0 2021 Poly(ADP-ribose) glycohydrolase silencing-mediated H2B expression inhibits benzo(a)pyrene-induced carcinogenesis. pyrene 83-89 poly(ADP-ribose) glycohydrolase Homo sapiens 0-31 33044785-0 2021 Poly(ADP-ribose) glycohydrolase silencing-mediated H2B expression inhibits benzo(a)pyrene-induced carcinogenesis. pyrene 83-89 H2B clustered histone 21 Homo sapiens 51-54 33668579-6 2021 To remedy such challenges, in this work, we demonstrate the use of pyrene-tagged DNA aptamers (PTDA) for performing a one-step aptamer immobilization technique to implement a GFET-based biosensor for the detection of Interleukin-6 (IL-6) protein biomarker. pyrene 67-73 interleukin 6 Homo sapiens 217-230 33668579-6 2021 To remedy such challenges, in this work, we demonstrate the use of pyrene-tagged DNA aptamers (PTDA) for performing a one-step aptamer immobilization technique to implement a GFET-based biosensor for the detection of Interleukin-6 (IL-6) protein biomarker. pyrene 67-73 interleukin 6 Homo sapiens 232-236 33307397-6 2021 Whole-genome sequencing of ISTPL2 strain in the current study highlighted the key genes of pyrene metabolism, including alcohol dehydrogenase and ring hydroxylating dioxygenase alpha-subunit. pyrene 91-97 aldo-keto reductase family 1 member A1 Homo sapiens 120-141 33529041-0 2021 C2- and C1-Symmetric Configurationally Stable Pyrene-Fused [5]Helicenes Connected via Hexagonal and Heptagonal Rings. pyrene 46-52 complement C2 Homo sapiens 0-10 33529041-1 2021 In this paper, we describe the stereospecific synthesis and functional properties of C2- and C1-symmetric pyrene-fused [5]helicene molecules 1 and 2 connected via hexagonal and heptagonal rings, respectively. pyrene 106-112 complement C2 Homo sapiens 85-95 33718538-0 2021 Dataset on pyrene-labelled apolipoprotein A-I, model development and fitting to monitor oligomeric species of its lipid-free form. pyrene 11-17 apolipoprotein A1 Homo sapiens 27-45 33718538-1 2021 This article contains data for the self-association of pyrene-labelled single Cys-mutants of apolipoprotein A-I (apoA-I). pyrene 55-61 apolipoprotein A1 Homo sapiens 93-111 33718538-1 2021 This article contains data for the self-association of pyrene-labelled single Cys-mutants of apolipoprotein A-I (apoA-I). pyrene 55-61 apolipoprotein A1 Homo sapiens 113-119 33718538-2 2021 Mathematical models were developed to characterise the self-association events at different cysteine positions on apoA-I obtained as a function of protein concentration based on the multi-parametric spectrum of pyrene, particularly P-value and excimer emissions. pyrene 211-217 apolipoprotein A1 Homo sapiens 114-120 33249052-5 2021 Compared to BP, FA and PYR activated the AHR only weakly. pyrene 23-26 aryl hydrocarbon receptor Homo sapiens 41-44 33049604-0 2021 Development of pyrene-based fluorescent ether lipid as inhibitor of SK3 ion channels. pyrene 15-21 potassium calcium-activated channel subfamily N member 3 Homo sapiens 68-71 33049604-1 2021 We report the synthesis of three bioactive pyrene-based fluorescent analogues of Ohmline which is the most efficient and selective inhibitor of SK3 ion channel. pyrene 43-49 potassium calcium-activated channel subfamily N member 3 Homo sapiens 144-147 33249052-8 2021 FA and PYR were strong CAR agonists, whereas BP was less potent. pyrene 7-10 nuclear receptor subfamily 1 group I member 3 Homo sapiens 23-26 32898529-0 2020 IL-27 along with IL-28B ameliorates the pulmonary redox impairment, inflammation and immunosuppression in benzo(a)pyrene induced lung cancer bearing mice. pyrene 114-120 interleukin 27 Mus musculus 0-5 33160013-4 2020 In this work, novel pyrene modified nanocrystalline cellulose (NP-1) was designed as a fluorescence sensor for selective determination of Cd2+ in food and soil samples. pyrene 20-26 neuronal pentraxin 1 Homo sapiens 63-67 33160013-4 2020 In this work, novel pyrene modified nanocrystalline cellulose (NP-1) was designed as a fluorescence sensor for selective determination of Cd2+ in food and soil samples. pyrene 20-26 CD2 molecule Homo sapiens 138-141 32738369-6 2020 Pyrene, anthracene and fluoranthene showed weak AhR agonist activity. pyrene 0-6 aryl hydrocarbon receptor Homo sapiens 48-51 32898529-0 2020 IL-27 along with IL-28B ameliorates the pulmonary redox impairment, inflammation and immunosuppression in benzo(a)pyrene induced lung cancer bearing mice. pyrene 114-120 interferon lambda 3 Mus musculus 17-23 32887046-4 2020 For this method, good linear calibration curves of naphthalene and pyrene were obtained in the range of 0.50-10.0, 0.05-5.0 mug mL-1, respectively, and limits of detection were 0.211, 0.012 mug mL-1, respectively. pyrene 67-73 L1 cell adhesion molecule Mus musculus 128-132 32887046-4 2020 For this method, good linear calibration curves of naphthalene and pyrene were obtained in the range of 0.50-10.0, 0.05-5.0 mug mL-1, respectively, and limits of detection were 0.211, 0.012 mug mL-1, respectively. pyrene 67-73 L1 cell adhesion molecule Mus musculus 194-198 32856786-4 2020 Compared to the parent TBDMS-beta-CD, these derivatives exhibit at least a 10-fold increase in inclusion ability toward pyrene through cooperative guest binding with the CD cavity and the aromatic substituents at the 2-O position. pyrene 120-126 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 29-36 32867800-0 2020 Benzo(a)pyrene exposure induced neuronal loss, plaque deposition, and cognitive decline in APP/PS1 mice. pyrene 8-14 presenilin 1 Mus musculus 95-98 32484199-1 2020 Two chiral binaphthyl (BNp) derivatives bearing oppositely oriented ester linkers to two pyrene (Py) moieties [(R)/(S)-1 and (R)/(S)-2] enabled Py-origin circularly polarized luminescence (CPL), magnetic CPL (MCPL), and circular dichroism (CD). pyrene 89-95 natriuretic peptide B Homo sapiens 23-26 32572409-2 2020 In this work, we designed and synthesized a unique N-heterocyclic carbene compound with a pyrene tail group (NHCp) to investigate how carbene species can be used for the functionalization of graphene. pyrene 90-96 high mobility group nucleosomal binding domain 4 Homo sapiens 109-113 32304152-2 2020 Here we describe the first isolation of azaacene diradical dianion salts [(18-c-6)K(THF) 2 ] + [(18-c-6)K] + 1 2- and [(18-c-6)K(THF)] 2+ 2 2- by reduction of the neutral pyrene-fused azaacene derivatives 1 and 2 with excess potassium graphite in THF in the presence of 18-crown-6. pyrene 179-185 complement C6 Homo sapiens 78-81 32304152-2 2020 Here we describe the first isolation of azaacene diradical dianion salts [(18-c-6)K(THF) 2 ] + [(18-c-6)K] + 1 2- and [(18-c-6)K(THF)] 2+ 2 2- by reduction of the neutral pyrene-fused azaacene derivatives 1 and 2 with excess potassium graphite in THF in the presence of 18-crown-6. pyrene 179-185 complement C6 Homo sapiens 100-103 32304152-2 2020 Here we describe the first isolation of azaacene diradical dianion salts [(18-c-6)K(THF) 2 ] + [(18-c-6)K] + 1 2- and [(18-c-6)K(THF)] 2+ 2 2- by reduction of the neutral pyrene-fused azaacene derivatives 1 and 2 with excess potassium graphite in THF in the presence of 18-crown-6. pyrene 179-185 complement C6 Homo sapiens 100-103 32409577-0 2020 Dissociation of the AhR/ARNT complex by TGF-beta/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity. pyrene 118-124 aryl hydrocarbon receptor Homo sapiens 20-23 32409577-0 2020 Dissociation of the AhR/ARNT complex by TGF-beta/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity. pyrene 118-124 aryl hydrocarbon receptor nuclear translocator Homo sapiens 24-28 32409577-0 2020 Dissociation of the AhR/ARNT complex by TGF-beta/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity. pyrene 118-124 transforming growth factor alpha Homo sapiens 40-48 32109332-4 2020 This strategy utilizes glycosylase-induced excimer formation of pyrenes, and modified DNA probes, incorporating two pyrene deoxynucleotides and a damaged base, enable the direct, real-time detection of NTH1 activity in vitro and in cellular lysates. pyrene 64-70 nth like DNA glycosylase 1 Homo sapiens 202-206 32057901-9 2020 In addition, Arl4c expression was downregulated via inhibition of the AKT pathway in A549 and 95-D cells, whereas exposure to benzo (a) pyrene (a carcinogen in smoke) increased Arl4c expression in 16HBE cells via AKT activation. pyrene 136-142 ADP ribosylation factor like GTPase 4C Homo sapiens 13-18 32095808-0 2020 Thrombin binding aptamer G-quadruplex stabilized by pyrene-modified nucleotides. pyrene 52-58 coagulation factor II, thrombin Homo sapiens 0-8 32095808-5 2020 We have investigated the effect of pyrene-modified uridine nucleotides incorporated at several positions of the thrombin binding aptamer (TBA) as a model system. pyrene 35-41 coagulation factor II, thrombin Homo sapiens 112-120 32095808-8 2020 Site specific structural changes induced by stacking of the pyrene moiety on nearby nucleobases corelate with distinct thrombin binding affinities and increased resistance against nuclease degradation. pyrene 60-66 coagulation factor II, thrombin Homo sapiens 119-127 32057901-9 2020 In addition, Arl4c expression was downregulated via inhibition of the AKT pathway in A549 and 95-D cells, whereas exposure to benzo (a) pyrene (a carcinogen in smoke) increased Arl4c expression in 16HBE cells via AKT activation. pyrene 136-142 ADP ribosylation factor like GTPase 4C Homo sapiens 177-182 32057901-9 2020 In addition, Arl4c expression was downregulated via inhibition of the AKT pathway in A549 and 95-D cells, whereas exposure to benzo (a) pyrene (a carcinogen in smoke) increased Arl4c expression in 16HBE cells via AKT activation. pyrene 136-142 AKT serine/threonine kinase 1 Homo sapiens 213-216 32201780-5 2020 The results from pyrene used as the fluorescence probe indicate that the features in the fluorescence spectrum (including fluorescence quenching, I 1/I 3, and the excimer) well correspond to those from the UV-vis spectrum mentioned above. pyrene 17-23 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 146-153 31670044-0 2020 A highly sensitive fluorescent sensor for Cd2+ and Zn2+ based on diarylethene with a pyrene unit. pyrene 85-91 CD2 molecule Homo sapiens 42-45 31718975-1 2020 We developed PIM, a pyrene-based fluorescence sensor bearing an imidazole moiety and a carbonyl group as the binding sites for Fe3+ ions. pyrene 20-26 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 13-16 32001104-11 2020 DNA-binding 99mTc-labeled pyrene induced less SSB and DSB compared to [99mTc]TcO4-. pyrene 26-32 small RNA binding exonuclease protection factor La Homo sapiens 46-49 31854988-5 2020 Interestingly, we also obtained another type of pyrene-stacking characteristic crystal of Ir-1, which had an emission resembled the phosphorescence observed in thin film. pyrene 48-54 nischarin Homo sapiens 90-94 31599884-4 2019 With this simple SERS sensor, qualitative and quantitative determination of trace-level naphthalene (NaP), phenanthrene (PHE) and pyrene (PYR) were achieved using a portable Raman spectrometer at detection limits of 1.38 mug L-1, 0.23 mug L-1, and 0.45 mug L-1, respectively. pyrene 130-136 immunoglobulin kappa variable 1-16 Homo sapiens 225-228 31709435-4 2019 Furthermore, the amine functionality could be used to install hydrophobic fluorophores such as coumarin and pyrene, thereby obtaining the final PGD-PNB structures which are highly water-soluble and fluorescent. pyrene 108-114 phosphoglycerate dehydrogenase Homo sapiens 144-147 31277030-0 2019 An AIE active pyrene based fluorescent probe for selective sensing Hg2+ and imaging in live cells. pyrene 14-20 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 67-70 31561077-0 2019 Is NLRP3 or NLRP6 inflammasome activation associated with inflammation-related lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide? pyrene 117-123 NLR family, pyrin domain containing 3 Mus musculus 3-8 31062603-6 2019 FG-C18 NMs appeared as spherical particles under transmission electron microscopy and possessed a critical micellar concentration of 0.042 mg/ml by pyrene fluorescence probe method. pyrene 148-154 Bardet-Biedl syndrome 9 Homo sapiens 3-6 31599884-4 2019 With this simple SERS sensor, qualitative and quantitative determination of trace-level naphthalene (NaP), phenanthrene (PHE) and pyrene (PYR) were achieved using a portable Raman spectrometer at detection limits of 1.38 mug L-1, 0.23 mug L-1, and 0.45 mug L-1, respectively. pyrene 130-136 immunoglobulin kappa variable 1-16 Homo sapiens 239-242 31599884-4 2019 With this simple SERS sensor, qualitative and quantitative determination of trace-level naphthalene (NaP), phenanthrene (PHE) and pyrene (PYR) were achieved using a portable Raman spectrometer at detection limits of 1.38 mug L-1, 0.23 mug L-1, and 0.45 mug L-1, respectively. pyrene 130-136 immunoglobulin kappa variable 1-16 Homo sapiens 239-242 31599884-4 2019 With this simple SERS sensor, qualitative and quantitative determination of trace-level naphthalene (NaP), phenanthrene (PHE) and pyrene (PYR) were achieved using a portable Raman spectrometer at detection limits of 1.38 mug L-1, 0.23 mug L-1, and 0.45 mug L-1, respectively. pyrene 138-141 immunoglobulin kappa variable 1-16 Homo sapiens 225-228 31599884-4 2019 With this simple SERS sensor, qualitative and quantitative determination of trace-level naphthalene (NaP), phenanthrene (PHE) and pyrene (PYR) were achieved using a portable Raman spectrometer at detection limits of 1.38 mug L-1, 0.23 mug L-1, and 0.45 mug L-1, respectively. pyrene 138-141 immunoglobulin kappa variable 1-16 Homo sapiens 239-242 31599884-4 2019 With this simple SERS sensor, qualitative and quantitative determination of trace-level naphthalene (NaP), phenanthrene (PHE) and pyrene (PYR) were achieved using a portable Raman spectrometer at detection limits of 1.38 mug L-1, 0.23 mug L-1, and 0.45 mug L-1, respectively. pyrene 138-141 immunoglobulin kappa variable 1-16 Homo sapiens 239-242 31687396-7 2019 Pyrene upregulated mRNA expression of phase I enzymes including CYP1A1, 1A2, and CYP1B1 and inflammatory markers including TNFalpha and Cox2. pyrene 0-6 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 81-87 31617512-0 2019 QCM sensing of miR-21 by formation of microRNA-DNA hybrid duplexes and intercalation on surface-functionalized pyrene. pyrene 111-117 microRNA 21 Homo sapiens 15-21 31617512-3 2019 Here, quartz crystal microbalance (QCM) biosensors were developed for sensitive and specific detection of miR-21 through formation of miR-21-DNA hybrid duplexes and non-specific intercalation of surface-modified pyrene molecules. pyrene 212-218 microRNA 21 Homo sapiens 106-112 31200196-11 2019 6-bromobenzene[a]pyrene was dominated among the HPAHs with a concentration from 2.30 to 2.69 ng L-1. pyrene 17-23 immunoglobulin kappa variable 1-16 Homo sapiens 96-99 31441544-1 2019 A convenient supramolecular strategy for constructing a ratiometric fluorescent chemosensing ensemble, consisting of a macrocyclic host (cucurbit[8]uril CB[8]), and a pyrene-tagged amphiphilic peptide beacon (AP 1), is reported. pyrene 167-173 ubiquitin like 5 Homo sapiens 201-207 31441544-1 2019 A convenient supramolecular strategy for constructing a ratiometric fluorescent chemosensing ensemble, consisting of a macrocyclic host (cucurbit[8]uril CB[8]), and a pyrene-tagged amphiphilic peptide beacon (AP 1), is reported. pyrene 167-173 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 209-213 31441544-2 2019 AP 1 unfolds upon encapsulation of the pyrene termini into the hydrophobic CB[8] cavity. pyrene 39-45 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 0-4 31441544-5 2019 The released AP 1 folds again to form a pyrene excimer, which allows for the ratiometric fluorescence monitoring of the substrate. pyrene 40-46 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 13-17 31693352-1 2019 Highly dense packing of chromophoric linkers is achieved in a novel pyrene-based metal-organic framework (MOF), [Zn(TBAPy)1/2(H2O)2], induced by an ionic liquid. pyrene 68-74 lysine acetyltransferase 8 Homo sapiens 81-111 31687396-5 2019 The possible mechanisms behind such effects were examined via studying the co exposure effects of pyrene and lycopene on regulatory elements including the aryl hydrocarbon receptor (Air) and elytroid 2-related factor 2 (RF). pyrene 98-104 aryl hydrocarbon receptor Homo sapiens 155-180 31687396-7 2019 Pyrene upregulated mRNA expression of phase I enzymes including CYP1A1, 1A2, and CYP1B1 and inflammatory markers including TNFalpha and Cox2. pyrene 0-6 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 64-70 31687396-7 2019 Pyrene upregulated mRNA expression of phase I enzymes including CYP1A1, 1A2, and CYP1B1 and inflammatory markers including TNFalpha and Cox2. pyrene 0-6 tumor necrosis factor Homo sapiens 123-131 31687396-7 2019 Pyrene upregulated mRNA expression of phase I enzymes including CYP1A1, 1A2, and CYP1B1 and inflammatory markers including TNFalpha and Cox2. pyrene 0-6 mitochondrially encoded cytochrome c oxidase II Homo sapiens 136-140 31348670-0 2019 PN-Containing Pyrene Derivatives: Synthesis, Structure, and Photophysical Properties. pyrene 14-20 U6 snRNA biogenesis phosphodiesterase 1 Homo sapiens 0-2 31377388-0 2019 Lysosome imaging in cancer cells by pyrene-benzothiazolium dyes: An alternative imaging approach for LAMP-1 expression based visualization methods to avoid background interference. pyrene 36-42 lysosomal associated membrane protein 1 Homo sapiens 101-107 31364241-4 2019 Under the optimum conditions, the limits of detection ranged between 0.1 ng mL-1 for pyrene to 1.2 ng mL-1 for anthracene, and limit of quantifications ranged between 0.3 ng mL-1 for pyrene to 3.6 ng mL-1 for anthracene. pyrene 85-91 L1 cell adhesion molecule Mus musculus 76-80 31368503-5 2019 Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). pyrene 126-132 aryl hydrocarbon receptor Rattus norvegicus 85-110 31122443-3 2019 The developed method gave the limits of detection (S/N = 3) from 0.02 (pyrene)-1.66 (naphthalene) ng L-1 and enhancement factors from 1069 (naphthalene)-10879 (benz(a)anthracene). pyrene 71-77 immunoglobulin kappa variable 1-16 Homo sapiens 101-104 31368503-5 2019 Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). pyrene 126-132 aryl hydrocarbon receptor Rattus norvegicus 112-115 31368503-5 2019 Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). pyrene 181-184 aryl hydrocarbon receptor Rattus norvegicus 112-115 30989406-0 2019 Fluorometric determination of cardiac myoglobin based on energy transfer from a pyrene-labeled aptamer to graphene oxide. pyrene 80-86 myoglobin Homo sapiens 38-47 30801798-5 2019 A pyrene-labeled m7 GTP analogue showed up to eightfold enhanced fluorescence emission upon binding to eukaryotic translation initiation factor 4E (eIF4E) and over 30-fold enhancement upon cleavage by decapping scavenger (DcpS) enzyme. pyrene 2-8 eukaryotic translation initiation factor 4E Homo sapiens 103-146 30801798-5 2019 A pyrene-labeled m7 GTP analogue showed up to eightfold enhanced fluorescence emission upon binding to eukaryotic translation initiation factor 4E (eIF4E) and over 30-fold enhancement upon cleavage by decapping scavenger (DcpS) enzyme. pyrene 2-8 eukaryotic translation initiation factor 4E Homo sapiens 148-153 30801798-5 2019 A pyrene-labeled m7 GTP analogue showed up to eightfold enhanced fluorescence emission upon binding to eukaryotic translation initiation factor 4E (eIF4E) and over 30-fold enhancement upon cleavage by decapping scavenger (DcpS) enzyme. pyrene 2-8 decapping enzyme, scavenger Homo sapiens 222-226 30939003-1 2019 The reaction mechanisms for the loss of C2H2 from the ions of anthracene, phenanthrene, tetracene, and pyrene were calculated at the B3-LYP/6-311++G(2d,p) level of theory and compared to that previously published for ionized naphthalene. pyrene 103-109 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 136-139 30989406-7 2019 Graphical abstract Schematic presentation of the detection of Mb (cardiac myoglobin) by using a fluorometric method based on pyrene-modified anti-Mb aptamer and GO (graphene oxide) through fluorescence quenching and subsequent recovery. pyrene 125-131 myoglobin Homo sapiens 74-83 30776468-5 2019 Compound 9i prevented CYP1A1-mediated benzo[a]pyrene-toxicity in normal fibroblasts whereas 9b completely reversed cisplatin resistance in PC-3/prostate, COR-L23/lung, MIAPaCa-2/pancreatic and LS174T/colon cancer cells, underlining the human-cell-assays" potential. pyrene 46-52 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 22-28 30640085-8 2019 The MWHIX also presented a good positive correlation with pyrene organic carbon-normalized binding coefficients (Koc). pyrene 58-64 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 113-116 30640085-9 2019 The prediction capability of the MWHIX for pyrene Koc was higher than those based on the single descriptors of bulk DOM, such as HIX and MW, which revealed its superior linkage with the DOM reactivity related to both MW and HIX. pyrene 43-49 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 50-53 30342339-3 2019 Here, a comprehensive study was carry out to understand the interaction between HSA and the pyrene derivative 1-pyrenesulfonic acid (PMS), which showed a singular behaviour when bound to this protein. pyrene 92-98 proline rich protein BstNI subfamily 1 Homo sapiens 133-136 30707840-6 2019 Without the presence of a pyrene-based linker, NU-1008, a MOF similar to NU-1000 with respect to surface area and pore size, removed <20% of the exposed atrazine. pyrene 26-32 lysine acetyltransferase 8 Homo sapiens 58-61 30707840-7 2019 These results suggest that the atrazine uptake capacity demonstrated by NU-1000 stems from the presence of a pyrene core in the MOF linker, affirming that pi-pi stacking is responsible for driving atrazine adsorption. pyrene 109-115 lysine acetyltransferase 8 Homo sapiens 128-131 29747128-1 2018 A lactose modified pyrene derivative (Py-Lac) was synthesized, with which novel twisted supramolecular nanofibers in diameter about 20 nm were constructed by self-assembly. pyrene 19-25 lactase Homo sapiens 41-44 30566147-1 2019 The Pt(bodipy)-(mercaptopyrene) dyad BPtSPyr shows four different emissions: intense near-infrared phosphorescence (Phiph up to 15%) from a charge-transfer state pyrS +-Pt-BDP -, additional fluorescence and phosphorescence emissions from the 1pipi* and 3pipi* states of the bodipy ligand at r.t., and phosphorescence from the pyrene 3pipi* and the bodipy 3pipi* states in a glassy matrix at 77 K. pyrene 24-30 AT-rich interaction domain 3B Homo sapiens 172-175 30248327-0 2018 Evidence of selective activation of aryl hydrocarbon receptor nongenomic calcium signaling by pyrene. pyrene 94-100 aryl hydrocarbon receptor Homo sapiens 36-61 30248327-3 2018 In the present study we observed that pyrene induced a relatively rapid increase in intracellular Ca2+-concentrations ([Ca2+]i) in human microvascular endothelial cells (HMEC-1) and human embryonic kidney cells (HEK293) that was attenuated by AhR-inhibitor treatment and/or transient AhR knockdown by RNAi. pyrene 38-44 aryl hydrocarbon receptor Homo sapiens 243-246 30248327-3 2018 In the present study we observed that pyrene induced a relatively rapid increase in intracellular Ca2+-concentrations ([Ca2+]i) in human microvascular endothelial cells (HMEC-1) and human embryonic kidney cells (HEK293) that was attenuated by AhR-inhibitor treatment and/or transient AhR knockdown by RNAi. pyrene 38-44 aryl hydrocarbon receptor Homo sapiens 284-287 30248327-5 2018 Instead, pyrene docked in the antagonist conformation of the AhR PAS-B binding pocket, although the interaction differed from antagonists such as GNF-351 and CH223191. pyrene 9-15 aryl hydrocarbon receptor Homo sapiens 61-64 30248327-6 2018 Accordingly, pyrene did not induce CYP1A1 or CYP1B1, but suppressed CYP1-expression by benzo[a]pyrene (B[a]P) in HMEC-1 cells, confirming that pyrene act as an antagonist of AhR-induced gene expression. pyrene 13-19 aryl hydrocarbon receptor Homo sapiens 174-177 30248327-7 2018 Use of pharmacological inhibitors and Ca2+-free medium indicated that the pyrene-induced AhR nongenomic [Ca2+]i increase was initiated by Ca2+-release from intracellular stores followed by a later phase of extracellular Ca2+-influx, consistent with store operated calcium entry (SOCE). pyrene 74-80 aryl hydrocarbon receptor Homo sapiens 89-92 30248327-10 2018 In conclusion, we propose that pyrene binds to AhR, act as an antagonist of the canonical genomic AhR/Arnt/CYP1-pathway, reduces ordered membrane lipid domains, and activates AhR nongenomic Ca2+-signaling from intracellular stores. pyrene 31-37 aryl hydrocarbon receptor Homo sapiens 47-50 30248327-10 2018 In conclusion, we propose that pyrene binds to AhR, act as an antagonist of the canonical genomic AhR/Arnt/CYP1-pathway, reduces ordered membrane lipid domains, and activates AhR nongenomic Ca2+-signaling from intracellular stores. pyrene 31-37 aryl hydrocarbon receptor Homo sapiens 98-101 30248327-10 2018 In conclusion, we propose that pyrene binds to AhR, act as an antagonist of the canonical genomic AhR/Arnt/CYP1-pathway, reduces ordered membrane lipid domains, and activates AhR nongenomic Ca2+-signaling from intracellular stores. pyrene 31-37 aryl hydrocarbon receptor nuclear translocator Homo sapiens 102-106 30248327-10 2018 In conclusion, we propose that pyrene binds to AhR, act as an antagonist of the canonical genomic AhR/Arnt/CYP1-pathway, reduces ordered membrane lipid domains, and activates AhR nongenomic Ca2+-signaling from intracellular stores. pyrene 31-37 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 107-111 30248327-10 2018 In conclusion, we propose that pyrene binds to AhR, act as an antagonist of the canonical genomic AhR/Arnt/CYP1-pathway, reduces ordered membrane lipid domains, and activates AhR nongenomic Ca2+-signaling from intracellular stores. pyrene 31-37 aryl hydrocarbon receptor Homo sapiens 98-101 30251528-0 2018 Photodegradation Rate Constants for Anthracene and Pyrene Are Similar in/on Ice and in Aqueous Solution. pyrene 51-57 carboxylesterase 2 Homo sapiens 76-79 30251528-5 2018 Here we examine the photodegradation of two common PAHs, anthracene and pyrene, in/on ice and in solution. pyrene 72-78 carboxylesterase 2 Homo sapiens 86-89 31459392-2 2019 This paper deals with the design and development of a glucosyl conjugate of pyrene (L 1 ) along with control molecular systems, possessing anthracenyl (L 2 ), naphtyl (L 3 ), and phenyl (L 4 ) moieties, via Knoevenagel condensation of 2,4-pentanedione with d-glucose. pyrene 76-82 L1 cell adhesion molecule Homo sapiens 84-87 31459392-2 2019 This paper deals with the design and development of a glucosyl conjugate of pyrene (L 1 ) along with control molecular systems, possessing anthracenyl (L 2 ), naphtyl (L 3 ), and phenyl (L 4 ) moieties, via Knoevenagel condensation of 2,4-pentanedione with d-glucose. pyrene 76-82 ribosomal protein L4 Homo sapiens 187-190 30240548-7 2018 We further observed that mRNA levels of several hepatic metabolizing enzymes regulated by constitutive androstane receptor (CAR) such as CYP2B1 and CYP2B2 significantly increased in pyrene-exposed rats. pyrene 182-188 nuclear receptor subfamily 1, group I, member 3 Rattus norvegicus 90-122 30240548-7 2018 We further observed that mRNA levels of several hepatic metabolizing enzymes regulated by constitutive androstane receptor (CAR) such as CYP2B1 and CYP2B2 significantly increased in pyrene-exposed rats. pyrene 182-188 nuclear receptor subfamily 1, group I, member 3 Rattus norvegicus 124-127 30240548-7 2018 We further observed that mRNA levels of several hepatic metabolizing enzymes regulated by constitutive androstane receptor (CAR) such as CYP2B1 and CYP2B2 significantly increased in pyrene-exposed rats. pyrene 182-188 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 137-143 30240548-7 2018 We further observed that mRNA levels of several hepatic metabolizing enzymes regulated by constitutive androstane receptor (CAR) such as CYP2B1 and CYP2B2 significantly increased in pyrene-exposed rats. pyrene 182-188 cytochrome P450, family 2, subfamily b, polypeptide 2 Rattus norvegicus 148-154 30240548-8 2018 These results suggest that decreased GSH levels, elevated hepatic metabolizing enzyme gene expression, and CAR activation are important contributors for pyrene-induced hepatotoxicity in rats. pyrene 153-159 nuclear receptor subfamily 1, group I, member 3 Rattus norvegicus 107-110 30185029-9 2018 Finally, we showed that the ELP/HA coacervates were able to sequester the hydrophobic fluorescent molecule pyrene, highlighting their potential for use as delivery vehicles for hydrophobic payloads. pyrene 107-113 nuclear receptor subfamily 5 group A member 1 Homo sapiens 28-31 30053373-1 2018 A heavy-atom-free triplet sensitizer suitable for triplet-triplet annihilation-based photon upconversion was developed from the thermally activated delayed fluorescence (TADF) molecule 4CzPN by covalently tethering a pyrene derivative (DBP) as a triplet acceptor. pyrene 217-223 D-box binding PAR bZIP transcription factor Homo sapiens 236-239 30225303-1 2018 This article present data related to the publication entitled "Interactions of pyrene and/or 1-hydroxypyrene with bovine serum albumin based on EEM-PARAFAC combined with molecular docking" (Zhang et al., 2018) [1]. pyrene 79-85 albumin Homo sapiens 121-134 29606035-6 2018 When AHR concentration was analyzed by ELISA in these organs, pyrene showed maximum potency in inducing AHR in thymus. pyrene 62-68 aryl hydrocarbon receptor Homo sapiens 5-8 30057009-5 2018 Changes in acrylodan tropomyosin fluorescence and the degree of Ca2+ stimulation of the rate of binding of rigor myosin subfragment 1 to pyrene-labeled actin-tropomyosin-troponin were measured at low Ca2+. pyrene 137-143 carbonic anhydrase 2 Homo sapiens 64-67 30057009-5 2018 Changes in acrylodan tropomyosin fluorescence and the degree of Ca2+ stimulation of the rate of binding of rigor myosin subfragment 1 to pyrene-labeled actin-tropomyosin-troponin were measured at low Ca2+. pyrene 137-143 carbonic anhydrase 2 Homo sapiens 200-203 30057009-9 2018 We also observed that the rate of binding of rigor subfragment 1 to pyrene-labeled regulated actin at saturating Ca2+ was higher for the truncation mutants than for wild-type TnT. pyrene 68-74 carbonic anhydrase 2 Homo sapiens 113-116 30057009-9 2018 We also observed that the rate of binding of rigor subfragment 1 to pyrene-labeled regulated actin at saturating Ca2+ was higher for the truncation mutants than for wild-type TnT. pyrene 68-74 troponin T1, slow skeletal type Homo sapiens 175-178 29777906-0 2018 Reduced RAR-beta gene expression in Benzo(a)Pyrene induced lung cancer mice is upregulated by DOTAP lipo-ATRA treatment. pyrene 44-50 retinoic acid receptor, beta Mus musculus 8-16 29704673-1 2018 In this study, we investigated the in situ responses of Red Sea picophytoplankton, the dominant phytoplankton group in the oligotrophic ocean, to two toxic polycyclic aromatic hydrocarbons (PAHs), phenanthrene and pyrene. pyrene 214-220 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 60-63 29881857-0 2018 Development of pyrene-stacked carbon nanotube-based hybrid: measurement of NO3- ions using fluorescence spectroscopy. pyrene 15-21 NBL1, DAN family BMP antagonist Homo sapiens 75-78 29606035-6 2018 When AHR concentration was analyzed by ELISA in these organs, pyrene showed maximum potency in inducing AHR in thymus. pyrene 62-68 aryl hydrocarbon receptor Homo sapiens 104-107 29478645-6 2018 Most probably, the lack of the correlations in Warsaw was due to the existence of an unidentified indoor source of gaseous PAH enriching PM1 in phenanthrene, fluorene, and pyrene. pyrene 172-178 transmembrane protein 11 Homo sapiens 137-140 31458669-1 2018 The intensity ratio between the first (373 nm) and the third (383 nm) vibronic peaks [I 1/I 3, as the pyrene (Py) scale] of fluorescent Py was used to monitor the critical concentration, drug-loading, and -releasing behaviors of a Py-terminated, amphiphilic polypeptide PPM and its hydrogen-bonded interpolymer complex (HIPC) with poly(acrylic acid) (PAA). pyrene 102-108 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 86-93 31458669-1 2018 The intensity ratio between the first (373 nm) and the third (383 nm) vibronic peaks [I 1/I 3, as the pyrene (Py) scale] of fluorescent Py was used to monitor the critical concentration, drug-loading, and -releasing behaviors of a Py-terminated, amphiphilic polypeptide PPM and its hydrogen-bonded interpolymer complex (HIPC) with poly(acrylic acid) (PAA). pyrene 110-112 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 86-93 29463680-8 2018 Our results indicate that cofilin-induced changes in filament twist propagate only 1-2 subunits from the boundary into the bare actin segment, independently of the boundary polarity (i.e. irrespective of whether or not the bare actin segment flanks the pointed or barbed-end side of the boundary) and the pyrene fluorophore labeling of actin. pyrene 305-311 cofilin 1 Homo sapiens 26-33 29316482-0 2018 Selective binding of pyrene in subdomain IB of human serum albumin: Combining energy transfer spectroscopy and molecular modelling to understand protein binding flexibility. pyrene 21-27 albumin Homo sapiens 53-66 29316482-7 2018 The fluorescence vibronic peak ratio I1/I3 of bound pyrene inside HSA indicates the presence of polar effect in the local environment of pyrene which is less than that of free pyrene in buffer. pyrene 52-58 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 37-42 29316482-7 2018 The fluorescence vibronic peak ratio I1/I3 of bound pyrene inside HSA indicates the presence of polar effect in the local environment of pyrene which is less than that of free pyrene in buffer. pyrene 137-143 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 37-42 29316482-7 2018 The fluorescence vibronic peak ratio I1/I3 of bound pyrene inside HSA indicates the presence of polar effect in the local environment of pyrene which is less than that of free pyrene in buffer. pyrene 137-143 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 37-42 29471073-0 2018 The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells. pyrene 112-118 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 29471073-0 2018 The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells. pyrene 112-118 tumor protein p53 Homo sapiens 155-159 29289134-6 2017 This model can predict the tendency of PAH dimerization as validated by pyrene dimerization experiments [H. Sabbah et al., J. Phys. pyrene 72-78 phenylalanine hydroxylase Homo sapiens 39-42 29298881-4 2018 Pathway analysis on the up-regulated gene list untraveled enrichment in multiple signaling pathways including insulin receptor signaling, focal Adhesion, metapathway biotransformation, a number of metabolic pathways e.g. selenium metabolism, Benzo(a)pyrene metabolism, fatty acid, triacylglycerol, ketone body metabolism, tryptophan metabolism, and catalytic cycle of mammalian flavin-containing monooxygenase (FMOs). pyrene 250-256 insulin Homo sapiens 110-117 29076178-0 2017 Limited ability of DNA polymerase kappa to suppress benzo[a]pyrene-induced genotoxicity in vivo. pyrene 60-66 polymerase (DNA directed), kappa Mus musculus 19-39 29262603-3 2017 This conclusion is supported by studies showing that: 1) activation of EMT programming by TGF-beta1 increases LINE-1 mRNAs and protein; 2) the lung carcinogen benzo(a)pyrene coregulates TGF-beta1 and LINE-1 mRNAs, with LINE-1 positioned downstream of TGF-beta1 signaling; and, 3) forced expression of LINE-1 in BEAS-2B cells recapitulates EMT programming and induces malignant phenotypes and tumorigenesis in vivo. pyrene 167-173 transforming growth factor, beta 1 Mus musculus 90-99 29029043-4 2017 In the present study, a microbially driven Fenton reaction, previously shown to produce hydroxyl (HO ) radicals that degrade chlorinated solvents and associated solvent stabilizers, was also found to degrade source zone concentrations of the oil spill components, pyrene (10 muM) and anthracene (1 muM), at initial rates of 0.82 and 0.20 muM h -1 , respectively. pyrene 266-272 latexin Homo sapiens 277-280 29029043-4 2017 In the present study, a microbially driven Fenton reaction, previously shown to produce hydroxyl (HO ) radicals that degrade chlorinated solvents and associated solvent stabilizers, was also found to degrade source zone concentrations of the oil spill components, pyrene (10 muM) and anthracene (1 muM), at initial rates of 0.82 and 0.20 muM h -1 , respectively. pyrene 266-272 latexin Homo sapiens 300-303 29029043-4 2017 In the present study, a microbially driven Fenton reaction, previously shown to produce hydroxyl (HO ) radicals that degrade chlorinated solvents and associated solvent stabilizers, was also found to degrade source zone concentrations of the oil spill components, pyrene (10 muM) and anthracene (1 muM), at initial rates of 0.82 and 0.20 muM h -1 , respectively. pyrene 266-272 latexin Homo sapiens 300-303 29143027-3 2017 Here, we report on the formation of a covalent C-C bonding motif, namely 1,3-cyclobutadiene, via surface-confined [2 + 2] cycloaddition between pyrene moieties using low temperature scanning tunneling microscopy (LT-STM) and X-ray photoemission spectroscopy (XPS) measurements. pyrene 144-150 sulfotransferase family 1A member 3 Homo sapiens 216-219 29262603-3 2017 This conclusion is supported by studies showing that: 1) activation of EMT programming by TGF-beta1 increases LINE-1 mRNAs and protein; 2) the lung carcinogen benzo(a)pyrene coregulates TGF-beta1 and LINE-1 mRNAs, with LINE-1 positioned downstream of TGF-beta1 signaling; and, 3) forced expression of LINE-1 in BEAS-2B cells recapitulates EMT programming and induces malignant phenotypes and tumorigenesis in vivo. pyrene 167-173 transforming growth factor, beta 1 Mus musculus 186-195 29262603-3 2017 This conclusion is supported by studies showing that: 1) activation of EMT programming by TGF-beta1 increases LINE-1 mRNAs and protein; 2) the lung carcinogen benzo(a)pyrene coregulates TGF-beta1 and LINE-1 mRNAs, with LINE-1 positioned downstream of TGF-beta1 signaling; and, 3) forced expression of LINE-1 in BEAS-2B cells recapitulates EMT programming and induces malignant phenotypes and tumorigenesis in vivo. pyrene 167-173 transforming growth factor, beta 1 Mus musculus 186-195 28525863-4 2017 Fukui calculations along with MEP plot predict the electrophilic nature of the silver cluster in the presence of pyrene, with NBO analysis revealing that the adsorption causes charge redistribution from the first three rings of pyrene towards the fourth ring, from where the 2p orbitals of carbon interact with the valence 5s orbitals of the cluster. pyrene 113-119 neurolysin Homo sapiens 30-33 31457676-1 2017 An azo-linked covalent organic polymer, Py-azo-COP, was synthesized by employing a highly blue-fluorescent pyrene derivative that is multiply substituted with bulky isopropyl groups. pyrene 107-113 caspase recruitment domain family member 16 Homo sapiens 47-50 28721413-0 2017 Spacer type mediated tunable spin crossover (SCO) characteristics of pyrene decorated 2,6-bis(pyrazol-1-yl)pyridine (bpp) based Fe(ii) molecular spintronic modules. pyrene 69-75 spindlin 1 Homo sapiens 29-33 28550418-0 2017 Nonlinear Optical Properties of Pyrene Based Fluorescent Hemicurcuminoid and their BF2 Complexes -Spectroscopic and DFT Studies. pyrene 32-38 forkhead box G1 Homo sapiens 83-86 28631468-0 2017 Pyrene-Tagged Ionic Liquids: Separable Organic Catalysts for SN2 Fluorination. pyrene 0-6 solute carrier family 38 member 5 Homo sapiens 61-64 28631468-2 2017 In this system, the PIL significantly enhanced the reactivity of MF due to the phase-transfer catalytic effect of the imidazolium moiety as well as the metal cation-pi (pyrene) interactions. pyrene 169-175 serpin family A member 2 (gene/pseudogene) Homo sapiens 20-23 28631468-3 2017 Furthermore, this homogeneous catalyst PIL was easily separated from the reaction mixture using reduced graphene oxide by pi-pi stacking with the pyrene of PIL. pyrene 146-152 serpin family A member 2 (gene/pseudogene) Homo sapiens 39-42 28631468-3 2017 Furthermore, this homogeneous catalyst PIL was easily separated from the reaction mixture using reduced graphene oxide by pi-pi stacking with the pyrene of PIL. pyrene 146-152 serpin family A member 2 (gene/pseudogene) Homo sapiens 156-159 28600683-10 2017 Fluoranthene, phenanthrene and pyrene were found in the highest concentrations in both the Jukskei and Klip River sediments. pyrene 31-37 TNFAIP3 interacting protein 2 Homo sapiens 103-107 28412278-0 2017 Disruption of glutamate neurotransmitter transmission is modulated by SNAP-25 in benzo[a]pyrene-induced neurotoxic effects. pyrene 89-95 synaptosome associated protein 25 Homo sapiens 70-77 28041555-1 2017 Agarose-chitosan-immobilized octadecylsilyl-silica (C18) film micro-solid phase extraction (muSPE) was developed and applied for the determination of phenanthrene (PHE) and pyrene (PYR) in chrysanthemum tea samples using high performance liquid chromatography-ultraviolet detection (HPLC-UV). pyrene 173-179 Bardet-Biedl syndrome 9 Homo sapiens 52-55 28426086-1 2017 Multiple pyrenes as pendants of enantioimpure di-/tripeptides (abbreviated as N-LD-C, N-DL-C, N-LLD-C and N-DDL-C) showed pyrene-origin CPL and CD signals, which were associated with conflicting CPL-/CD-signs, compared to the corresponding enantiopure di-/tri-peptides. pyrene 9-15 hephaestin Homo sapiens 136-139 28426086-1 2017 Multiple pyrenes as pendants of enantioimpure di-/tripeptides (abbreviated as N-LD-C, N-DL-C, N-LLD-C and N-DDL-C) showed pyrene-origin CPL and CD signals, which were associated with conflicting CPL-/CD-signs, compared to the corresponding enantiopure di-/tri-peptides. pyrene 9-15 hephaestin Homo sapiens 195-198 28414462-0 2017 Pyrene-Apelin Conjugation Modulates Fluorophore- and Peptide-Micelle Interactions. pyrene 0-6 apelin Homo sapiens 7-13 28414462-4 2017 Pyrene photophysics are consistent with an expected partitioning into the hydrophobic micellar cores, while pyrene-apelin conjugation prevented this partitioning. pyrene 108-114 apelin Homo sapiens 115-121 28414462-6 2017 Finally, Forster resonance energy transfer between pyrene and tryptophan residues in the N-terminal tail and first transmembrane segment (the AR55 construct, comprising residues 1-55 of the AR) was consistent with efficient nonspecific pyrene-apelin conjugate binding to micelles rather than direct, specific apelin-AR55 binding. pyrene 51-57 apelin Homo sapiens 243-249 28414462-6 2017 Finally, Forster resonance energy transfer between pyrene and tryptophan residues in the N-terminal tail and first transmembrane segment (the AR55 construct, comprising residues 1-55 of the AR) was consistent with efficient nonspecific pyrene-apelin conjugate binding to micelles rather than direct, specific apelin-AR55 binding. pyrene 51-57 apelin Homo sapiens 309-315 28414462-6 2017 Finally, Forster resonance energy transfer between pyrene and tryptophan residues in the N-terminal tail and first transmembrane segment (the AR55 construct, comprising residues 1-55 of the AR) was consistent with efficient nonspecific pyrene-apelin conjugate binding to micelles rather than direct, specific apelin-AR55 binding. pyrene 236-242 apelin Homo sapiens 243-249 28414462-6 2017 Finally, Forster resonance energy transfer between pyrene and tryptophan residues in the N-terminal tail and first transmembrane segment (the AR55 construct, comprising residues 1-55 of the AR) was consistent with efficient nonspecific pyrene-apelin conjugate binding to micelles rather than direct, specific apelin-AR55 binding. pyrene 236-242 apelin Homo sapiens 309-315 28522830-7 2017 Imaging flow cytometry also showed that CD1a and CD1d proteins were retained in early and late endosomal compartments, respectively, supporting an impaired endocytic lipid antigen presentation for T cell activation upon benzo[a]pyrene exposure. pyrene 228-234 CD1a molecule Homo sapiens 40-44 28522830-7 2017 Imaging flow cytometry also showed that CD1a and CD1d proteins were retained in early and late endosomal compartments, respectively, supporting an impaired endocytic lipid antigen presentation for T cell activation upon benzo[a]pyrene exposure. pyrene 228-234 CD1d molecule Homo sapiens 49-53 28041555-1 2017 Agarose-chitosan-immobilized octadecylsilyl-silica (C18) film micro-solid phase extraction (muSPE) was developed and applied for the determination of phenanthrene (PHE) and pyrene (PYR) in chrysanthemum tea samples using high performance liquid chromatography-ultraviolet detection (HPLC-UV). pyrene 181-184 Bardet-Biedl syndrome 9 Homo sapiens 52-55 28238438-4 2017 ARID2 depletion attenuated nucleotide excision repair (NER) of DNA damage sites introduced by exposure to UV as well as chemical compounds known as carcinogens for HCC, benzo[a]pyrene and FeCl3, since xeroderma pigmentosum complementation group G (XPG) could not accumulate without ARID2. pyrene 177-183 AT-rich interaction domain 2 Homo sapiens 0-5 28337678-1 2017 Cation-pi interactions were systematically investigated for the adsorption of H+ and alkali metal cations M+ to pyrene by means of Moller-Plesset perturbation theory (MP2) and density functional theory (DFT). pyrene 112-118 tryptase pseudogene 1 Homo sapiens 167-170 28187856-0 2017 Corrigendum to "PCB153, TCDD and estradiol compromise the benzo[a]pyrene-induced p53-response via FoxO3a" [Chem. pyrene 66-72 tumor protein p53 Homo sapiens 81-84 28187856-0 2017 Corrigendum to "PCB153, TCDD and estradiol compromise the benzo[a]pyrene-induced p53-response via FoxO3a" [Chem. pyrene 66-72 forkhead box O3 Homo sapiens 98-104 28192968-4 2017 In this work, a measurement of within-particle molecular transport is carried out using confocal Raman microscopy to probe the time-dependent accumulation of pyrene from an aqueous mobile phase into the center of individual C18-chromatographic particles. pyrene 158-164 Bardet-Biedl syndrome 9 Homo sapiens 224-227 27402563-0 2017 Neuropeptide Y expression confers benzo[a]pyrene induced anxiolytic like behavioral response during early adolescence period of male Wistar rats. pyrene 42-48 neuropeptide Y Rattus norvegicus 0-14 28010926-8 2017 Acenaphthene, indene [1,2,3-cd] pyrene, and pyrene concentrations correlated with higher dinucleotide methylation in OGG1, APEX and PARP1 genes, respectively. pyrene 32-38 8-oxoguanine DNA glycosylase Homo sapiens 117-121 27901495-5 2017 Furthermore, benzo(a)pyrene-induced DKK2 and EN1 promoter hypermethylation and LPAR2 promoter hypomethylation led to down-regulation and up-regulation of the genes, respectively; the down-regulation of DKK2 and EN1 promoted the cellular proliferation. pyrene 21-27 dickkopf WNT signaling pathway inhibitor 2 Mus musculus 36-40 27901495-5 2017 Furthermore, benzo(a)pyrene-induced DKK2 and EN1 promoter hypermethylation and LPAR2 promoter hypomethylation led to down-regulation and up-regulation of the genes, respectively; the down-regulation of DKK2 and EN1 promoted the cellular proliferation. pyrene 21-27 engrailed 1 Mus musculus 45-48 27901495-5 2017 Furthermore, benzo(a)pyrene-induced DKK2 and EN1 promoter hypermethylation and LPAR2 promoter hypomethylation led to down-regulation and up-regulation of the genes, respectively; the down-regulation of DKK2 and EN1 promoted the cellular proliferation. pyrene 21-27 lysophosphatidic acid receptor 2 Mus musculus 79-84 27901495-5 2017 Furthermore, benzo(a)pyrene-induced DKK2 and EN1 promoter hypermethylation and LPAR2 promoter hypomethylation led to down-regulation and up-regulation of the genes, respectively; the down-regulation of DKK2 and EN1 promoted the cellular proliferation. pyrene 21-27 dickkopf WNT signaling pathway inhibitor 2 Mus musculus 202-206 27901495-5 2017 Furthermore, benzo(a)pyrene-induced DKK2 and EN1 promoter hypermethylation and LPAR2 promoter hypomethylation led to down-regulation and up-regulation of the genes, respectively; the down-regulation of DKK2 and EN1 promoted the cellular proliferation. pyrene 21-27 engrailed 1 Mus musculus 211-214 28010926-8 2017 Acenaphthene, indene [1,2,3-cd] pyrene, and pyrene concentrations correlated with higher dinucleotide methylation in OGG1, APEX and PARP1 genes, respectively. pyrene 32-38 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 123-127 28010926-8 2017 Acenaphthene, indene [1,2,3-cd] pyrene, and pyrene concentrations correlated with higher dinucleotide methylation in OGG1, APEX and PARP1 genes, respectively. pyrene 32-38 poly(ADP-ribose) polymerase 1 Homo sapiens 132-137 31964082-7 2016 The immobilization strategy is limited to applications below 1.4 V vs normal hydrogen electrode (NHE) as oxidation of the pyrene backbone is evident at higher potentials. pyrene 122-128 solute carrier family 9 member C1 Homo sapiens 97-100 27931814-4 2016 As a part of this collaborative study, the in vivo mutagenicity of a single dose of pyrene (Pyr) was investigated in the red blood cell (RBC Pig-a assay) and in reticulocytes (PIGRET) of rats. pyrene 92-95 phosphatidylinositol glycan anchor biosynthesis class A Sus scrofa 141-146 27931814-4 2016 As a part of this collaborative study, the in vivo mutagenicity of a single dose of pyrene (Pyr) was investigated in the red blood cell (RBC Pig-a assay) and in reticulocytes (PIGRET) of rats. pyrene 84-90 phosphatidylinositol glycan anchor biosynthesis class A Sus scrofa 141-146 25946486-0 2016 The Nrf2-ARE pathway is associated with Schisandrin b attenuating benzo(a)pyrene-Induced HTR cells damages in vitro. pyrene 74-80 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 27534383-4 2016 HS 1 switches from pyrene monomer emission to an excimer emission. pyrene 19-25 eukaryotic translation elongation factor 1 alpha 2 Homo sapiens 0-4 27131996-1 2016 This manuscript reports the synthesis of pyrene-based fluorescent probe (PA-1) containing alpha,beta-unsaturated carbonyl moiety and its application towards the selective and sensitive detection of cysteine (Cys) over other bio-thiols. pyrene 41-47 PAXIP1 associated glutamate rich protein 1 Homo sapiens 73-77 27534383-9 2016 Addition of the polycationic protein protamine releases both HS 1 and HS 2 from their heparin complex, which simultaneously restores pyrene monomer emission for the first case and decreases the FRET process for the latter case, respectively. pyrene 133-139 eukaryotic translation elongation factor 1 alpha 2 Homo sapiens 61-65 27534383-9 2016 Addition of the polycationic protein protamine releases both HS 1 and HS 2 from their heparin complex, which simultaneously restores pyrene monomer emission for the first case and decreases the FRET process for the latter case, respectively. pyrene 133-139 spectrin beta, erythrocytic Homo sapiens 70-74 27419849-4 2016 Selective sensing is based on a CS2-specific reaction with hydrophilic amino groups to produce hydrophobic dithiocarbamate moieties, which can strongly quench the pyrene excimer emission via a known photoinduced electron transfer (PET) mechanism. pyrene 163-169 chorionic somatomammotropin hormone 2 Homo sapiens 32-35 27412733-2 2016 In this work, two D-A molecules, Ph-BPA-BPI and Py-BPA-BPI, have been synthesized by attaching highly fluorescent phenanthrene or pyrene groups to the C6- and C9-positions of a locally excited-state emitting phenylamine-phenanthroimidazole moiety. pyrene 130-136 bactericidal permeability increasing protein Homo sapiens 40-43 27412733-2 2016 In this work, two D-A molecules, Ph-BPA-BPI and Py-BPA-BPI, have been synthesized by attaching highly fluorescent phenanthrene or pyrene groups to the C6- and C9-positions of a locally excited-state emitting phenylamine-phenanthroimidazole moiety. pyrene 130-136 bactericidal permeability increasing protein Homo sapiens 55-58 27412733-2 2016 In this work, two D-A molecules, Ph-BPA-BPI and Py-BPA-BPI, have been synthesized by attaching highly fluorescent phenanthrene or pyrene groups to the C6- and C9-positions of a locally excited-state emitting phenylamine-phenanthroimidazole moiety. pyrene 130-136 complement C6 Homo sapiens 151-161 27526190-3 2016 Using live cell imaging, in vivo and in vitro protein binding assays, and in vitro pyrene-actin polymerization assays, we show that the yeast Rab GTPase Sec4p couples polarized exocytosis with cortical actin polymerization, which induces endocytosis. pyrene 83-89 actin Saccharomyces cerevisiae S288C 90-95 27526190-3 2016 Using live cell imaging, in vivo and in vitro protein binding assays, and in vitro pyrene-actin polymerization assays, we show that the yeast Rab GTPase Sec4p couples polarized exocytosis with cortical actin polymerization, which induces endocytosis. pyrene 83-89 Rab family GTPase SEC4 Saccharomyces cerevisiae S288C 153-158 27403579-4 2016 The pyrene polarity index and curcumin fluorescence anisotropy measurements suggest that phospholipid/NaC mixed micelles have a more compact structure than that of phospholipid vesicles and phospholipid/NaC mixed vesicles. pyrene 4-10 synuclein alpha Homo sapiens 102-105 27286764-2 2016 We describe a quantitative exposure assessment approach for five lung carcinogens (i.e. asbestos, chromium-VI, nickel, polycyclic aromatic hydrocarbons (by its proxy benzo(a)pyrene (BaP)) and respirable crystalline silica). pyrene 174-180 prohibitin 2 Homo sapiens 182-185 27364983-1 2016 The fusion of the sp(3) -hybridized parent diamondoid adamantane with the sp(2) -hybridized pyrene results in a hybrid structure with a very large dipole moment which arises from bending the pyrene moiety. pyrene 92-98 Sp3 transcription factor Homo sapiens 18-23 27364983-1 2016 The fusion of the sp(3) -hybridized parent diamondoid adamantane with the sp(2) -hybridized pyrene results in a hybrid structure with a very large dipole moment which arises from bending the pyrene moiety. pyrene 92-98 Sp2 transcription factor Homo sapiens 74-79 27364983-1 2016 The fusion of the sp(3) -hybridized parent diamondoid adamantane with the sp(2) -hybridized pyrene results in a hybrid structure with a very large dipole moment which arises from bending the pyrene moiety. pyrene 191-197 Sp3 transcription factor Homo sapiens 18-23 27364983-1 2016 The fusion of the sp(3) -hybridized parent diamondoid adamantane with the sp(2) -hybridized pyrene results in a hybrid structure with a very large dipole moment which arises from bending the pyrene moiety. pyrene 191-197 Sp2 transcription factor Homo sapiens 74-79 27120415-1 2016 Pyrene-bridged boron subphthalocyanine dimers were synthesized from a mixed-condensation reaction of 2,7-di-tert-butyl-4,5,9,10-tetracyanopyrene and tetrafluorophthalonitrile, and their syn and anti isomers arising from the result of connecting two bowl-shaped boron subphthalocyanine molecules were successfully separated. pyrene 0-6 synemin Homo sapiens 51-54 27279258-0 2016 Experimental evidence of incomplete fluorescence quenching of pyrene bound to humic substances: implications for Koc measurements. pyrene 62-68 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 113-116 27279258-4 2016 Pyrene was used as a fluorescent probe, and aquatic fulvic acid (SRFA) and leonardite humic acid (CHP) were used as the humic materials with low and high binding affinity for pyrene, respectively. pyrene 175-181 calcineurin like EF-hand protein 1 Homo sapiens 98-101 27279258-6 2016 This was indicative of incomplete quenching of the bound pyrene, and the divergence of the two FQ curves was much more pronounced for CHP as compared to SRFA. pyrene 57-63 calcineurin like EF-hand protein 1 Homo sapiens 134-137 27279258-8 2016 The resulting pyrene KOC value for CHP (220 +- 20) g L(-1) was a factor 3 higher compared to the KOC value determined with the use of the Stern-Volmer formalism (68 +- 2) g L(-1). pyrene 14-20 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 21-24 27279258-8 2016 The resulting pyrene KOC value for CHP (220 +- 20) g L(-1) was a factor 3 higher compared to the KOC value determined with the use of the Stern-Volmer formalism (68 +- 2) g L(-1). pyrene 14-20 calcineurin like EF-hand protein 1 Homo sapiens 35-57 26807522-0 2016 Cyclic up-regulation fluorescence of pyrene excimer for studying polynucleotide kinase activity based on dual amplification. pyrene 37-43 polynucleotide kinase 3'-phosphatase Homo sapiens 65-86 26807522-2 2016 Herein, a homogeneous and sensitive fluorescence assay has been proposed for the detection of PNK activity by integrating target recycling signal amplification of DNA toehold strand displacement reaction (TSDR) with gamma-cyclodextrin (gamma-CD) enhancement of pyrene excimer. pyrene 261-267 polynucleotide kinase 3'-phosphatase Homo sapiens 94-97 26807522-7 2016 Thus, TSDR-induced cyclic formation of pyrene excimer and gamma-CD enhancement can specifically up-regulate the fluorescence of pyrene excimer for detection of PNK activity, the detection limit is 9.3 x 10(-5)UmL(-1), which is superior to those of most existing approaches. pyrene 39-45 polynucleotide kinase 3'-phosphatase Homo sapiens 160-163 26807522-7 2016 Thus, TSDR-induced cyclic formation of pyrene excimer and gamma-CD enhancement can specifically up-regulate the fluorescence of pyrene excimer for detection of PNK activity, the detection limit is 9.3 x 10(-5)UmL(-1), which is superior to those of most existing approaches. pyrene 128-134 polynucleotide kinase 3'-phosphatase Homo sapiens 160-163 29997800-0 2016 Remarkably selective and enantiodifferentiating sensing of histidine by a fluorescent homochiral Zn-MOF based on pyrene-tetralactic acid. pyrene 113-119 lysine acetyltransferase 8 Homo sapiens 100-103 27065057-7 2016 The desorption rate from HOPG electrode increased in the order Ru-1 with eight pyrene groups (k = 2.0 x 10(-5) s(-1)) < Ru-2 with four pyrenes (4.1 x 10(-5) s(-1)) < Ru-3 with two pyrenes (6.8 x 10(-5) s(-1)) << Ru-4 with one pyrene (4.1 x 10(-3) s(-1)). pyrene 79-85 Scm like with four mbt domains 1 Homo sapiens 63-67 27065057-7 2016 The desorption rate from HOPG electrode increased in the order Ru-1 with eight pyrene groups (k = 2.0 x 10(-5) s(-1)) < Ru-2 with four pyrenes (4.1 x 10(-5) s(-1)) < Ru-3 with two pyrenes (6.8 x 10(-5) s(-1)) << Ru-4 with one pyrene (4.1 x 10(-3) s(-1)). pyrene 79-85 doublecortin domain containing 2 Homo sapiens 123-127 27065057-7 2016 The desorption rate from HOPG electrode increased in the order Ru-1 with eight pyrene groups (k = 2.0 x 10(-5) s(-1)) < Ru-2 with four pyrenes (4.1 x 10(-5) s(-1)) < Ru-3 with two pyrenes (6.8 x 10(-5) s(-1)) << Ru-4 with one pyrene (4.1 x 10(-3) s(-1)). pyrene 138-144 Scm like with four mbt domains 1 Homo sapiens 63-67 26757403-0 2016 Fluorescent Detection of 2,4-DNT and 2,4,6-TNT in Aqueous Media by Using Simple Water-Soluble Pyrene Derivatives. pyrene 94-100 5', 3'-nucleotidase, cytosolic Homo sapiens 29-32 26996611-2 2016 The pyrene-excimer based CPL was reversibly controlled by a geometrical change of the tetrathiazole upon photoisomerization. pyrene 4-10 hephaestin Homo sapiens 25-28 26679620-0 2016 Steric hindrance regulated supramolecular assembly between beta-cyclodextrin polymer and pyrene for alkaline phosphatase fluorescent sensing. pyrene 89-95 alkaline phosphatase, placental Homo sapiens 100-120 26679620-1 2016 We herein report a strategy for sensitive alkaline phosphatase (ALP) fluorescent sensing based on steric hindrance regulated supramolecular assembly between beta-cyclodextrin polymer (polybeta-CD) and pyrene. pyrene 201-207 alkaline phosphatase, placental Homo sapiens 42-62 26757403-0 2016 Fluorescent Detection of 2,4-DNT and 2,4,6-TNT in Aqueous Media by Using Simple Water-Soluble Pyrene Derivatives. pyrene 94-100 chromosome 16 open reading frame 82 Homo sapiens 43-46 26757403-1 2016 Pyrene-containing water-soluble probes for the fluorescent detection of nitroaromatic compounds (NACs), such as explosive components (2,4-DNT and 2,4,6-TNT) and herbicides (2,4-dinitrocresol, 2,4-DNOC), in aqueous media are reported. pyrene 0-6 5', 3'-nucleotidase, cytosolic Homo sapiens 138-141 26757403-1 2016 Pyrene-containing water-soluble probes for the fluorescent detection of nitroaromatic compounds (NACs), such as explosive components (2,4-DNT and 2,4,6-TNT) and herbicides (2,4-dinitrocresol, 2,4-DNOC), in aqueous media are reported. pyrene 0-6 chromosome 16 open reading frame 82 Homo sapiens 152-155 26573838-1 2016 The adsorption behavior of pyrene on corncob was studied to provide a theoretical basis for the possible use of this material as an immobilized carrier for improving the bioremediation of PAH-contaminated soil. pyrene 27-33 phenylalanine hydroxylase Homo sapiens 188-191 30090398-4 2016 Using human recombinant GST and plasma as well as erythrocytes collected from normal subjects this study demonstrates that out of the ten compounds, nicotine (5 mg mL-1), benzo[a]pyrene (10 ng mL-1), naphthalene (250 mug mL-1), and formaldehyde (5 pg mL-1) caused a significant decrease in recombinant, plasma, and erythrocyte GST activity. pyrene 179-185 L1 cell adhesion molecule Mus musculus 193-197 30090398-4 2016 Using human recombinant GST and plasma as well as erythrocytes collected from normal subjects this study demonstrates that out of the ten compounds, nicotine (5 mg mL-1), benzo[a]pyrene (10 ng mL-1), naphthalene (250 mug mL-1), and formaldehyde (5 pg mL-1) caused a significant decrease in recombinant, plasma, and erythrocyte GST activity. pyrene 179-185 L1 cell adhesion molecule Mus musculus 193-197 30090398-4 2016 Using human recombinant GST and plasma as well as erythrocytes collected from normal subjects this study demonstrates that out of the ten compounds, nicotine (5 mg mL-1), benzo[a]pyrene (10 ng mL-1), naphthalene (250 mug mL-1), and formaldehyde (5 pg mL-1) caused a significant decrease in recombinant, plasma, and erythrocyte GST activity. pyrene 179-185 L1 cell adhesion molecule Mus musculus 193-197 26842224-2 2016 The filaments of the fusion protein were functionally similar to actin filaments bound with cofilin in that they did not bind rhodamine-phalloidin, had quenched fluorescence of pyrene attached to Cys374 and showed enhanced susceptibility of the DNase loop to cleavage by subtilisin. pyrene 177-183 cofilin 1 Homo sapiens 92-99 26840286-1 2016 A novel series of pyrene containing thiophene monomers TPM1-5 were synthesized and fully characterized by FTIR, MS, 1H- and (13)C-NMR spectroscopy; their thermal properties were determined by TGA and DSC. pyrene 18-24 tropomyosin 1 Homo sapiens 55-61 26840286-1 2016 A novel series of pyrene containing thiophene monomers TPM1-5 were synthesized and fully characterized by FTIR, MS, 1H- and (13)C-NMR spectroscopy; their thermal properties were determined by TGA and DSC. pyrene 18-24 T-box transcription factor 1 Homo sapiens 192-195 26604180-1 2016 A novel pyrene-conjugated squaraine fluorescent probe SQ-P, which could self-assemble into nanoparticles in aqueous solution through multiple interactions, was designed to selectively detect serum albumin with a turn-on response in the near infrared (NIR) region. pyrene 8-14 albumin Homo sapiens 197-204 26604127-1 2016 The light-harvesting properties of two fluorescent dynamic conjugated microporous organic polymers (Py-PP and Py-BPP) rendered with pyrene chromophores are described. pyrene 132-138 sushi repeat containing protein X-linked 2 Homo sapiens 113-116 26291476-0 2015 Quantum Chemical Investigation of Light-Activated Spin State Change in Pyrene Coupled to Oxoverdazyl Radical Center. pyrene 71-77 spindlin 1 Homo sapiens 50-54 27110039-7 2016 Since CYP2S1 was shown to catalyze oxidation of compounds having polycyclic aromatic structures, the prepared enzyme has been tested to metabolize the compounds having this structural character; namely, the human carcinogen benzo[a]pyrene (BaP), its 7,8-dihydrodiol derivative, and an anticancer drug ellipticine. pyrene 232-238 cytochrome P450 family 2 subfamily S member 1 Homo sapiens 6-12 26247835-0 2016 Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13. pyrene 13-19 cytochrome P450 family 2 subfamily A member 13 Homo sapiens 80-100 26247835-2 2016 The polycyclic hydrocarbons (PAHs), pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene, were found to induce Type I binding spectra with human cytochrome P450 (P450) 2A13 and were converted to various mono- and di-oxygenated products by this enzyme. pyrene 36-42 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 150-177 26247835-5 2016 Of five other human P450s examined, P450 1B1 catalyzed pyrene oxidation to 1-hydroxypyrene at a similar rate to P450 2A13 but was less efficient in forming dihydroxypyrenes. pyrene 55-61 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 36-44 26247835-11 2016 In addition, Phe-231 and Gly-329 were found to interact with pyrene to orient this compound in the active site of P450 1B1. pyrene 61-67 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 114-122 26186091-0 2016 Mouse Pig-a and micronucleus assays respond to N-ethyl-N-nitrosourea, benzo[a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate. pyrene 78-84 phosphatidylinositol glycan anchor biosynthesis class A Sus scrofa 6-11 26496743-9 2016 RT-PCR confirmed expression changes in several genes related to apoptosis, iron metabolism, and aryl hydrocarbon receptor signaling that are regulated in the opposite direction during spleen atrophy versus benzo[a]pyrene-mediated splenomegaly. pyrene 214-220 aryl-hydrocarbon receptor Mus musculus 96-121 26160115-0 2015 Pyrene is a Novel Constitutive Androstane Receptor (CAR) Activator and Causes Hepatotoxicity by CAR. pyrene 0-6 nuclear receptor subfamily 1, group I, member 3 Mus musculus 18-66 26160115-0 2015 Pyrene is a Novel Constitutive Androstane Receptor (CAR) Activator and Causes Hepatotoxicity by CAR. pyrene 0-6 nuclear receptor subfamily 1, group I, member 3 Mus musculus 52-55 26160115-5 2015 The present study demonstrates that pyrene is able to activate mouse constitutive androstane receptor (CAR). pyrene 36-42 nuclear receptor subfamily 1, group I, member 3 Mus musculus 69-101 26160115-5 2015 The present study demonstrates that pyrene is able to activate mouse constitutive androstane receptor (CAR). pyrene 36-42 nuclear receptor subfamily 1, group I, member 3 Mus musculus 103-106 26160115-6 2015 CAR protein, as measured by Western blot analysis, was observed to translocate into the nucleus from the cytoplasm in mouse liver after exposure to pyrene. pyrene 148-154 nuclear receptor subfamily 1, group I, member 3 Mus musculus 0-3 26160115-7 2015 Utilizing CAR null mice, we identified that CAR mediates pyrene-induced hepatotoxicity. pyrene 57-63 nuclear receptor subfamily 1, group I, member 3 Mus musculus 10-13 26160115-7 2015 Utilizing CAR null mice, we identified that CAR mediates pyrene-induced hepatotoxicity. pyrene 57-63 nuclear receptor subfamily 1, group I, member 3 Mus musculus 44-47 26160115-9 2015 We further show that pyrene induced the expression of mouse liver metabolism enzymes including CYP2B10, CYP3A11, GSTm1, GSTm3, and SULT1A1, and caused hepatic glutathione depletion in wild-type but not CAR null mice. pyrene 21-27 cytochrome P450, family 2, subfamily b, polypeptide 10 Mus musculus 95-102 26160115-9 2015 We further show that pyrene induced the expression of mouse liver metabolism enzymes including CYP2B10, CYP3A11, GSTm1, GSTm3, and SULT1A1, and caused hepatic glutathione depletion in wild-type but not CAR null mice. pyrene 21-27 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 104-111 26160115-9 2015 We further show that pyrene induced the expression of mouse liver metabolism enzymes including CYP2B10, CYP3A11, GSTm1, GSTm3, and SULT1A1, and caused hepatic glutathione depletion in wild-type but not CAR null mice. pyrene 21-27 glutathione S-transferase, mu 1 Mus musculus 113-118 26160115-9 2015 We further show that pyrene induced the expression of mouse liver metabolism enzymes including CYP2B10, CYP3A11, GSTm1, GSTm3, and SULT1A1, and caused hepatic glutathione depletion in wild-type but not CAR null mice. pyrene 21-27 glutathione S-transferase, mu 3 Mus musculus 120-125 26160115-9 2015 We further show that pyrene induced the expression of mouse liver metabolism enzymes including CYP2B10, CYP3A11, GSTm1, GSTm3, and SULT1A1, and caused hepatic glutathione depletion in wild-type but not CAR null mice. pyrene 21-27 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 131-138 26160115-9 2015 We further show that pyrene induced the expression of mouse liver metabolism enzymes including CYP2B10, CYP3A11, GSTm1, GSTm3, and SULT1A1, and caused hepatic glutathione depletion in wild-type but not CAR null mice. pyrene 21-27 nuclear receptor subfamily 1, group I, member 3 Mus musculus 202-205 26160115-10 2015 Moreover, by luciferase reporter assay and quantitative real-time PCR analysis, pyrene was found to be a potential inducer of CYP2B6 expression via activation of human CAR in HepG2 cells and human primary hepatocytes. pyrene 80-86 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 126-132 26160115-10 2015 Moreover, by luciferase reporter assay and quantitative real-time PCR analysis, pyrene was found to be a potential inducer of CYP2B6 expression via activation of human CAR in HepG2 cells and human primary hepatocytes. pyrene 80-86 nuclear receptor subfamily 1 group I member 3 Homo sapiens 168-171 26160115-11 2015 Our observations suggest that pyrene is a novel CAR activator and that CAR is essential for mediating pyrene-induced liver injury. pyrene 30-36 nuclear receptor subfamily 1, group I, member 3 Mus musculus 48-51 26160115-11 2015 Our observations suggest that pyrene is a novel CAR activator and that CAR is essential for mediating pyrene-induced liver injury. pyrene 102-108 nuclear receptor subfamily 1, group I, member 3 Mus musculus 71-74 26592035-3 2015 The desorption rates of pyrene increased from 20% to 81.8% and 84.5% because of adding insoluble DP1 and DP120, and from 40% to 89.6% and 88.5% because of adding soluble DP1 and DP120. pyrene 24-30 transcription factor Dp-1 Homo sapiens 97-100 26184777-0 2015 Phenylboronic Acid Appended Pyrene-Based Low-Molecular-Weight Injectable Hydrogel: Glucose-Stimulated Insulin Release. pyrene 28-34 insulin Homo sapiens 102-109 26184777-1 2015 A pyrene-containing phenylboronic acid (PBA) functionalized low-molecular-weight hydrogelator was synthesized with the aim to develop glucose-sensitive insulin release. pyrene 2-8 insulin Homo sapiens 152-159 26126982-1 2015 The possibility of forming stable BeR2 :ArH:Y(-) (R=H, F, Cl; ArH=naphthalene, pyrene; Y=Cl, Br) ternary complexes in which the beryllium compounds and anions are located on the opposite sides of an extended aromatic system is explored by means of MP2/aug-cc-pVDZ ab initio calculations. pyrene 79-85 low density lipoprotein receptor adaptor protein 1 Homo sapiens 40-43 26126982-1 2015 The possibility of forming stable BeR2 :ArH:Y(-) (R=H, F, Cl; ArH=naphthalene, pyrene; Y=Cl, Br) ternary complexes in which the beryllium compounds and anions are located on the opposite sides of an extended aromatic system is explored by means of MP2/aug-cc-pVDZ ab initio calculations. pyrene 79-85 low density lipoprotein receptor adaptor protein 1 Homo sapiens 62-65 26592035-3 2015 The desorption rates of pyrene increased from 20% to 81.8% and 84.5% because of adding insoluble DP1 and DP120, and from 40% to 89.6% and 88.5% because of adding soluble DP1 and DP120. pyrene 24-30 transcription factor Dp-1 Homo sapiens 105-108 26592035-4 2015 (2) The sorption amounts of pyrene by insoluble DP1 and.DP120 were 9. pyrene 28-34 transcription factor Dp-1 Homo sapiens 48-51 26962300-3 2015 By using diversified iminophosphorane (PPh3=NR) reagents, pi-conjugated pyrene, redox active ferrocene and polymerizable norbornene moieties were successfully introduced. pyrene 72-78 caveolin 1 Homo sapiens 39-43 26288819-7 2015 The mutation rates of 70 genes (e.g., RYR2, MYH3, GPR144, CACNA1E) were associated with patients" lifetime benzo(a)pyrene exposure. pyrene 115-121 ryanodine receptor 2 Homo sapiens 38-42 25925496-1 2015 Chimerical pyrene-based dibenzo[7]helicene rac-1 and 2H-pyran[7]helicene (M,R,R)-(-)-2, in which two pyrene subunits are fused to the [7]helicene/[7]heterohelicene scaffold, were synthesised by means of Ni(0) - or Co(I) -mediated [2+2+2] cycloisomerisation of dipyrenyl-acetylene-derived triynes. pyrene 11-17 mitochondrially encoded cytochrome c oxidase I Homo sapiens 214-219 25877651-1 2015 A pyrene-fused pyrazaacene with only four linearly-fused aromatic rings is reported, which remarkably shows emission at red to NIR wavelengths (lambda(em) = 687 nm). pyrene 2-8 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 127-130 25925332-1 2015 In this paper, a pyrene moiety is incorporated into a bolaamphiphile to form a novel molecule denoted PRB. pyrene 17-23 RB transcriptional corepressor 1 Homo sapiens 102-105 25840912-4 2015 In vivo inhibition of HSP27 and HSP70 produced a reduction in the T cell-mediated immune response to 7,12-dimethylbenz(a)anthracene (DMBA) and benzo(a)pyrene in C3H/HeN mice and resulted in a state of Ag-specific tolerance. pyrene 151-157 heat shock protein 1 Mus musculus 22-27 25840912-4 2015 In vivo inhibition of HSP27 and HSP70 produced a reduction in the T cell-mediated immune response to 7,12-dimethylbenz(a)anthracene (DMBA) and benzo(a)pyrene in C3H/HeN mice and resulted in a state of Ag-specific tolerance. pyrene 151-157 heat shock protein 1B Mus musculus 32-37 25858839-1 2015 A polycyclic aromatic hydrocarbon-degrading bacterium designated strain Ca6, a member of the family Rhodocyclaceae and a representative of the uncharacterized pyrene group 1 (PG1), was isolated and its genome sequenced. pyrene 159-165 carbonic anhydrase 6 Homo sapiens 72-75 26288819-7 2015 The mutation rates of 70 genes (e.g., RYR2, MYH3, GPR144, CACNA1E) were associated with patients" lifetime benzo(a)pyrene exposure. pyrene 115-121 myosin heavy chain 3 Homo sapiens 44-48 26288819-7 2015 The mutation rates of 70 genes (e.g., RYR2, MYH3, GPR144, CACNA1E) were associated with patients" lifetime benzo(a)pyrene exposure. pyrene 115-121 adhesion G protein-coupled receptor D2 Homo sapiens 50-56 26288819-7 2015 The mutation rates of 70 genes (e.g., RYR2, MYH3, GPR144, CACNA1E) were associated with patients" lifetime benzo(a)pyrene exposure. pyrene 115-121 calcium voltage-gated channel subunit alpha1 E Homo sapiens 58-65 25799099-6 2015 We found that addition of mSA to an optimized construct in lipid vesicles led to a complete and reversible loss in pyrene excimer fluorescence and mSA binding, and hence hairpin unfolding--results further supported by SDS-PAGE visualization of mSA bound and unbound species. pyrene 115-121 exonuclease 1 Mus musculus 26-29 25524617-2 2015 Pyrene, as a PAH, was covalently linked to carrier protein bovine serum albumin and ovalbumin. pyrene 0-6 albumin Homo sapiens 66-79 25645610-3 2015 We show that pyrene fluorescence can sensitively detect micellelike oligomer formation by IAPP and discriminate between micellelike oligomers from fibers and monomers, making pyrene one of the few chemical probes specific to a prefibrillar oligomer. pyrene 13-19 islet amyloid polypeptide Homo sapiens 90-94 25646669-5 2015 In the CLOSED form of Adk labeled by a pyrene probe with a short linker, excimer emission was found to be predominated by the ground-state association of pyrenes. pyrene 39-45 adenosine kinase Homo sapiens 22-25 25231738-3 2015 The COP-Compost model was evaluated via composting experiments containing 16 US Environmental Protection Agency (USEPA) polycyclic aromatic hydrocarbons (PAHs) and the sorption coefficient (Kd) values of two types of OP: fluorenthene (FLT) and pyrene (PHE). pyrene 244-250 caspase recruitment domain family member 16 Homo sapiens 4-7 26262471-4 2015 Additionally, with ferrocene-functionalized films, we observe that the MOF"s pyrene-based linkers, which are otherwise reversibly electroactive, are now redox-silent. pyrene 77-83 lysine acetyltransferase 8 Homo sapiens 71-74 26757127-11 2015 In the study utilizing the HepG2 cells, DHM showed only an additive effect on the benzo[a]pyrene-mediated activation of Ah receptor. pyrene 90-96 aryl hydrocarbon receptor Homo sapiens 120-131 25410825-3 2015 Upon forming a 1:1 complex with pyrene in acetonitrile, however, BlueCage 6 PF6 exhibits a lower association constant Ka than its progenitor ExCage 6 PF6. pyrene 32-38 sperm associated antigen 17 Homo sapiens 76-79 25410825-3 2015 Upon forming a 1:1 complex with pyrene in acetonitrile, however, BlueCage 6 PF6 exhibits a lower association constant Ka than its progenitor ExCage 6 PF6. pyrene 32-38 sperm associated antigen 17 Homo sapiens 150-153 25410825-5 2015 This conclusion is supported by a one order of magnitude increase in the Ka value for pyrene in BlueCage(6+) when the PF6(-) counterions are replaced by much bulkier anions. pyrene 86-92 sperm associated antigen 17 Homo sapiens 118-121 25854346-6 2015 RESULTS: Findings revealed that PEITC inhibited benzo[a]pyrene-induced rise in rat liver CYP1A1 mRNA in a dose-dependent manner as well as the apoprotein levels of CYP1A. pyrene 56-62 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 89-95 25607750-4 2015 Pyrene behaved as a donor when a strong acceptor group (-CN) was attached to the phenyl ring and it behaved as an acceptor when the phenyl group contained a strong donor group (-NMe2). pyrene 0-6 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 178-182 25535708-4 2014 After 14 days of incubation, pyrene and phenantherene were degraded by a combination of BP10 and P2 to the extent of 98% and 99%, respectively. pyrene 29-35 BP10 Homo sapiens 88-92 26123509-0 2015 Pyrene functionalized molecular beacon with pH-sensitive i-motif in a loop. pyrene 0-6 ubiquitin like 5 Homo sapiens 32-38 26123509-3 2015 ~480 nm) by pyrene labels at the ends of the molecular beacon is driven by pH-dependent i-motif formation in the loop. pyrene 12-18 ubiquitin like 5 Homo sapiens 55-61 25535708-6 2014 Biosurfactant produced by selected strains i.e. BP10 and P2 could enhance desorption of pyrene (100 mug g-1of soil) by about 27% and 12%, respectively. pyrene 88-94 BP10 Homo sapiens 48-52 25291259-2 2014 The steady-state fluorescence spectra showed that the I1/I3 ratio decreased from 1.73 +- 0.06 for SDS concentration smaller than 2 mM where pyrene was exposed to water to 1.43 +- 0.03 for SDS concentration greater than 6 mM where pyrene was incorporated inside SDS micelles. pyrene 140-146 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 54-59 25291259-2 2014 The steady-state fluorescence spectra showed that the I1/I3 ratio decreased from 1.73 +- 0.06 for SDS concentration smaller than 2 mM where pyrene was exposed to water to 1.43 +- 0.03 for SDS concentration greater than 6 mM where pyrene was incorporated inside SDS micelles. pyrene 230-236 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 54-59 25329713-0 2014 Effects of humidity and [NO3]/[N2O5] ratio on the heterogeneous reaction of fluoranthene and pyrene with N2O5/NO3/NO2. pyrene 93-99 NBL1, DAN family BMP antagonist Homo sapiens 25-28 25329713-0 2014 Effects of humidity and [NO3]/[N2O5] ratio on the heterogeneous reaction of fluoranthene and pyrene with N2O5/NO3/NO2. pyrene 93-99 NBL1, DAN family BMP antagonist Homo sapiens 110-113