PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27913845-5	2017	In in situ perfused rat livers, these three MAPK inhibitors prevented tBuOOH (75 microM)-induced impairment of bile flow and the decrease in the biliary output of the Bsep and Mrp2 substrates, taurocholate, and dinitrophenyl-S-glutathione, respectively.	S-(2,4-dinitrophenyl)glutathione	211-238	mitogen activated protein kinase 3	Rattus norvegicus	44-48
2920011-6	1989	At optimal heparin concentrations, the rate of inactivation of alpha-thrombin by GdN was 0.5-1.2 nM-1.s-1, which suggests that, under these conditions, the interaction is diffusion-controlled.	S-(2,4-dinitrophenyl)glutathione	81-84	coagulation factor II, thrombin	Homo sapiens	69-77
2466482-2	1988	High-excitation energy-transfer efficiencies that approach those found in the native state were obtained for the reduced labeled BPTI derivatives in 0.5 M guanidine hydrochloride (Gdn.HCl) and 4 mM DTT.	S-(2,4-dinitrophenyl)glutathione	180-183	spleen trypsin inhibitor I	Bos taurus	129-133
3390440-2	1988	Formiminotransferase-cyclodeaminase denatured in 6 M guanidine hydrochloride (Gdn.HCl) refolds and reassembles to the native octameric structure upon dilution into buffer.	S-(2,4-dinitrophenyl)glutathione	78-81	formimidoyltransferase cyclodeaminase	Homo sapiens	0-35
20846144-4	2010	The ATP-dependent transport of a DNP-S-glutathione conjugate was reduced in a vesicular fraction from the VMR1 deletant.	S-(2,4-dinitrophenyl)glutathione	33-50	putative ATP-binding cassette multidrug transporter VMR1	Saccharomyces cerevisiae S288C	106-110
22453052-1	2012	The ability of the liver, small intestine, and kidney to synthesize and subsequently eliminate dinitrophenyl-S-glutathione (DNP-SG), a substrate for multidrug resistance-associated protein 2 (Mrp2), was assessed in rats treated with glucagon-like peptide 2 (GLP-2, 12 mug/100 g b.wt.	S-(2,4-dinitrophenyl)glutathione	95-122	ATP binding cassette subfamily C member 2	Rattus norvegicus	149-190
22453052-1	2012	The ability of the liver, small intestine, and kidney to synthesize and subsequently eliminate dinitrophenyl-S-glutathione (DNP-SG), a substrate for multidrug resistance-associated protein 2 (Mrp2), was assessed in rats treated with glucagon-like peptide 2 (GLP-2, 12 mug/100 g b.wt.	S-(2,4-dinitrophenyl)glutathione	95-122	ATP binding cassette subfamily C member 2	Rattus norvegicus	192-196
22132167-6	2011	We have carried out studies both in the presence and absence of urea and Gdn.HCl and compared the relationship between conformation of insulin induced by urea and Gdn.HCl with respect to NaCl at both pH 7.4 (hexamer) and pH 2 (monomer).	S-(2,4-dinitrophenyl)glutathione	163-166	insulin	Homo sapiens	135-142
22925079-7	2013	P-GP and MRP2 function in brain were determined using the brain-to-plasma ratios of corresponding substrates (rhodamine 123 and vincristine for P-GP; sulfobromophthalein and dinitrophenyl-S-glutathione for MRP2).	S-(2,4-dinitrophenyl)glutathione	174-201	ATP binding cassette subfamily C member 2	Rattus norvegicus	206-210
23272261-5	2012	P-gp and MRP2 activities were estimated using model substrates rhodamine 123 and dinitrophenyl-S-glutathione (DNP-SG), respectively.	S-(2,4-dinitrophenyl)glutathione	81-108	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
23272261-5	2012	P-gp and MRP2 activities were estimated using model substrates rhodamine 123 and dinitrophenyl-S-glutathione (DNP-SG), respectively.	S-(2,4-dinitrophenyl)glutathione	81-108	ATP binding cassette subfamily C member 2	Homo sapiens	9-13
23272261-5	2012	P-gp and MRP2 activities were estimated using model substrates rhodamine 123 and dinitrophenyl-S-glutathione (DNP-SG), respectively.	S-(2,4-dinitrophenyl)glutathione	110-116	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
23272261-5	2012	P-gp and MRP2 activities were estimated using model substrates rhodamine 123 and dinitrophenyl-S-glutathione (DNP-SG), respectively.	S-(2,4-dinitrophenyl)glutathione	110-116	ATP binding cassette subfamily C member 2	Homo sapiens	9-13
19766108-5	2009	The serosal to mucosal transport of dinitrophenyl S-glutathione, a model substrate of Mrp2 was evaluated in jejunal sac model.	S-(2,4-dinitrophenyl)glutathione	36-63	ATP binding cassette subfamily C member 2	Rattus norvegicus	86-90
19299525-3	2009	Mrp2 transport activity toward dinitrophenyl-S-glutathione (DNP-SG) was assessed in vitro in intestinal sacs.	S-(2,4-dinitrophenyl)glutathione	31-58	ATP binding cassette subfamily C member 2	Rattus norvegicus	0-4
19782883-8	2009	We concluded that MRP2 transporter is related to glucose stimulated DNPSG secretion.	S-(2,4-dinitrophenyl)glutathione	68-73	ATP binding cassette subfamily C member 2	Rattus norvegicus	18-22
19375851-4	2009	Both doxorubicin (DOX) and dinitro-phenyl S-glutathione (DNP-SG) transport were inhibited by cdc2 in a concentration dependent manner.	S-(2,4-dinitrophenyl)glutathione	27-55	cyclin dependent kinase 1	Homo sapiens	93-97
18450747-7	2008	The effects of the ALDH isoforms were dependent on the amount of added protein and, like 1,2-GDN formation, were sensitive to ALDH inhibitors.	S-(2,4-dinitrophenyl)glutathione	93-96	aldehyde dehydrogenase 1 family member A1	Homo sapiens	19-23
18450747-7	2008	The effects of the ALDH isoforms were dependent on the amount of added protein and, like 1,2-GDN formation, were sensitive to ALDH inhibitors.	S-(2,4-dinitrophenyl)glutathione	93-96	aldehyde dehydrogenase 1 family member A1	Homo sapiens	126-130
18450747-1	2008	Metabolism of nitroglycerin (GTN) to 1,2-glycerol dinitrate (GDN) and nitrite by mitochondrial aldehyde dehydrogenase (ALDH2) is essentially involved in GTN bioactivation resulting in cyclic GMP-mediated vascular relaxation.	S-(2,4-dinitrophenyl)glutathione	61-64	aldehyde dehydrogenase 2 family member	Homo sapiens	119-124
17606924-1	2007	Guanidine hydrochloride (Gdn.HCl) blocks the propagation of yeast prions by inhibiting Hsp104, a molecular chaperone that is absolutely required for yeast prion propagation.	S-(2,4-dinitrophenyl)glutathione	25-28	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	87-93
18450747-1	2008	Metabolism of nitroglycerin (GTN) to 1,2-glycerol dinitrate (GDN) and nitrite by mitochondrial aldehyde dehydrogenase (ALDH2) is essentially involved in GTN bioactivation resulting in cyclic GMP-mediated vascular relaxation.	S-(2,4-dinitrophenyl)glutathione	61-64	5'-nucleotidase, cytosolic II	Homo sapiens	191-194
18329043-5	2008	Interestingly, whereas GroES formed fibrils from either the Gdn-HCl unfolded state (at neutral pH) or the acidic unfolded state (at pH 2.0-3.0), Hhsp10, Rhsp10, and Gp31 formed fibrils from only the acidic unfolded state.	S-(2,4-dinitrophenyl)glutathione	60-63	heat shock protein family E (Hsp10) member 1	Homo sapiens	23-28
17709913-11	2007	The antioxidant normalized the hepatic handling of the Mrp2 substrates, rose bengal, and dinitrophenyl-S-glutathione, which was causally associated with restoration of Mrp2 expression.	S-(2,4-dinitrophenyl)glutathione	89-116	ATP binding cassette subfamily C member 2	Rattus norvegicus	168-172
16139386-4	2005	Impaired bile salt-independent bile flow in obese rats was associated with a 50% reduction of biliary secretion of the Mrp 2 model-substrates glutathione disulfide and S-(2,4-dinitrophenyl)glutathione.	S-(2,4-dinitrophenyl)glutathione	168-200	ATP binding cassette subfamily C member 2	Rattus norvegicus	119-124
16868766-5	2007	MRP8 is able to transport a diverse range of lipophilic anions, including cyclic nucleotides, E(2)17betaG, steroid sulfates such as dehydroepiandrosterone (DHEAS) and E(1)S, glutathione conjugates such as leukotriene C4 and dinitrophenyl-S-glutathione, and monoanionic bile acids.	S-(2,4-dinitrophenyl)glutathione	224-251	ATP binding cassette subfamily C member 11	Homo sapiens	0-4
17142317-2	2006	Using conformational-stability assays, we determined the guanidine hydrochloride (Gdn.HCl) concentration required to denature 50% of disease-causing prion protein (PrP(Sc)) molecules, denoted as the [Gdn.HCl](1/2) value.	S-(2,4-dinitrophenyl)glutathione	82-85	prion protein	Mus musculus	164-167
16797167-1	2006	Protease nexin-1 (PN-1)/glia-derived nexin (GDN) is a member of the Serpin (serine proteinase inhibitor) family, and can inhibit thrombin, plasmin, and plasminogen activators.	S-(2,4-dinitrophenyl)glutathione	44-47	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 L homeolog	Xenopus laevis	0-16
16797167-1	2006	Protease nexin-1 (PN-1)/glia-derived nexin (GDN) is a member of the Serpin (serine proteinase inhibitor) family, and can inhibit thrombin, plasmin, and plasminogen activators.	S-(2,4-dinitrophenyl)glutathione	44-47	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 L homeolog	Xenopus laevis	18-22
16797167-1	2006	Protease nexin-1 (PN-1)/glia-derived nexin (GDN) is a member of the Serpin (serine proteinase inhibitor) family, and can inhibit thrombin, plasmin, and plasminogen activators.	S-(2,4-dinitrophenyl)glutathione	44-47	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 L homeolog	Xenopus laevis	24-42
16797167-1	2006	Protease nexin-1 (PN-1)/glia-derived nexin (GDN) is a member of the Serpin (serine proteinase inhibitor) family, and can inhibit thrombin, plasmin, and plasminogen activators.	S-(2,4-dinitrophenyl)glutathione	44-47	serpin family A member 6 L homeolog	Xenopus laevis	68-74
15590889-0	2005	Involvement of Mrp2 in hepatic and intestinal disposition of dinitrophenyl-S-glutathione in partially hepatectomized rats.	S-(2,4-dinitrophenyl)glutathione	61-88	ATP binding cassette subfamily C member 2	Rattus norvegicus	15-19
15707977-5	2005	Both doxorubicin and a model GSH-conjugate, dinitrophenyl-S-glutathione (DNP-SG), transport were inhibited by POB1 in a concentration-dependent manner but not by POB1(1-512), lacking RLIP76-binding site.	S-(2,4-dinitrophenyl)glutathione	44-71	RALBP1 associated Eps domain containing 2	Homo sapiens	110-114
15590889-1	2005	The ability of the liver and small intestine for secretion of dinitrophenyl-S-glutathione (DNP-SG), a substrate for multidrug resistance-associated protein 2 (Mrp2), into bile and lumen, respectively, as well as expression of Mrp2 in both tissues, were assessed in 70-75% hepatectomized rats.	S-(2,4-dinitrophenyl)glutathione	62-89	ATP binding cassette subfamily C member 2	Rattus norvegicus	159-163
15652244-12	2005	Enhanced activity and expression of Mrp2 was confirmed by analyzing the excretion rate of dinitrophenyl S-glutathione, an exogenous substrate of Mrp2, in isolated hepatocytes and by immunofluorescence microscopy, respectively.	S-(2,4-dinitrophenyl)glutathione	90-117	ATP binding cassette subfamily C member 2	Rattus norvegicus	36-40
15652244-12	2005	Enhanced activity and expression of Mrp2 was confirmed by analyzing the excretion rate of dinitrophenyl S-glutathione, an exogenous substrate of Mrp2, in isolated hepatocytes and by immunofluorescence microscopy, respectively.	S-(2,4-dinitrophenyl)glutathione	90-117	ATP binding cassette subfamily C member 2	Rattus norvegicus	145-149
15276087-4	2004	In vivo biliary excretion of dinitrophenyl-S-glutathione, a well known Mrp2 substrate, was slightly but significantly increased by APAP, agreeing well with upregulation of the transporter.	S-(2,4-dinitrophenyl)glutathione	29-56	ATP binding cassette subfamily C member 2	Rattus norvegicus	71-75
12527936-8	2003	RLIP76 ATPase purified from NSCLC cell lines was about 2-fold more active than that from SCLC in the absence of the stimulator dinitrophenyl S-glutathione (206+/-47, n=7 vs. 94+/-22, n=6, nmol/min/mg protein, respectively), or in its presence (340+/-60, n=7 vs. 186+/-32, n=6, nmol/min/mg; p<0.01).	S-(2,4-dinitrophenyl)glutathione	127-154	ralA binding protein 1	Homo sapiens	0-6
14976346-7	2004	Expression of multidrug resistance-associated protein 2 (Mrp2), the main, multispecific transporter involved in the canalicular excretion of organic anions, was also decreased (-40%), which was associated with a significant decrease in the cumulative biliary excretion of the Mrp2 substrate, dinitrophenyl-S-glutathione (-50%).	S-(2,4-dinitrophenyl)glutathione	292-319	ATP binding cassette subfamily C member 2	Rattus norvegicus	14-55
14976346-7	2004	Expression of multidrug resistance-associated protein 2 (Mrp2), the main, multispecific transporter involved in the canalicular excretion of organic anions, was also decreased (-40%), which was associated with a significant decrease in the cumulative biliary excretion of the Mrp2 substrate, dinitrophenyl-S-glutathione (-50%).	S-(2,4-dinitrophenyl)glutathione	292-319	ATP binding cassette subfamily C member 2	Rattus norvegicus	57-61
14516191-5	2003	At pH 7.4, the addition of as little as 0.25 M Gdn.HCl leads to dissociation of insulin hexamers into dimers.	S-(2,4-dinitrophenyl)glutathione	47-50	insulin	Homo sapiens	80-87
12029626-6	2002	The biliary concentration and excretion of the model Mrp2 substrate, dinitrophenyl-S-glutathione (DNP-SG), was impaired in parallel with the extent of Mrp2 retrieval.	S-(2,4-dinitrophenyl)glutathione	69-96	ATP binding cassette subfamily C member 2	Rattus norvegicus	53-57
12029626-6	2002	The biliary concentration and excretion of the model Mrp2 substrate, dinitrophenyl-S-glutathione (DNP-SG), was impaired in parallel with the extent of Mrp2 retrieval.	S-(2,4-dinitrophenyl)glutathione	69-96	ATP binding cassette subfamily C member 2	Rattus norvegicus	151-155
12029626-6	2002	The biliary concentration and excretion of the model Mrp2 substrate, dinitrophenyl-S-glutathione (DNP-SG), was impaired in parallel with the extent of Mrp2 retrieval.	S-(2,4-dinitrophenyl)glutathione	98-104	ATP binding cassette subfamily C member 2	Rattus norvegicus	53-57
12029626-6	2002	The biliary concentration and excretion of the model Mrp2 substrate, dinitrophenyl-S-glutathione (DNP-SG), was impaired in parallel with the extent of Mrp2 retrieval.	S-(2,4-dinitrophenyl)glutathione	98-104	ATP binding cassette subfamily C member 2	Rattus norvegicus	151-155
10720481-5	2000	The dynamic quench constant for holo-alpha-LA remains unchanged until exposed to 2.5 M GDN/HCl, but increases by threefold with addition denaturant to 4 M GDN/HCl.	S-(2,4-dinitrophenyl)glutathione	87-90	lactalbumin alpha	Homo sapiens	37-45
11581266-5	2001	Membrane vesicles from infected insect cells expressing MRP3 mediated ATP-dependent transport of estradiol 17-beta-D-glucuronide, leukotriene C(4), dinitrophenyl S-glutathione but not glutathione itself, and etoposide glucuronide, a major metabolite of etoposide in vivo.	S-(2,4-dinitrophenyl)glutathione	148-175	ATP binding cassette subfamily C member 3	Homo sapiens	56-60
10917553-7	2000	V-104 partially inhibits the export of the organic anion dinitrophenyl S-glutathione by MDCKII-MRP1 but not by MDCKII-MRP2 cells.	S-(2,4-dinitrophenyl)glutathione	57-84	ATP binding cassette subfamily C member 1	Canis lupus familiaris	95-99
10908301-5	2000	Support for this hypothesis was provided by the demonstration of enhanced [(3)H]GSH and [(3)H]S-(2,4-dinitrophenyl)-glutathione efflux in Oatp2-expressing oocytes.	S-(2,4-dinitrophenyl)glutathione	96-127	solute carrier organic anion transporter family, member 1a4	Rattus norvegicus	138-143
10840050-5	2000	In polarized Madin-Darby canine kidney II (MDCKII) cells transfected with an MRP5 cDNA construct, MRP5 is routed to the basolateral membrane and these cells transport S-(2,4-dinitrophenyl)glutathione and glutathione preferentially toward the basal compartment.	S-(2,4-dinitrophenyl)glutathione	167-199	ATP binding cassette subfamily C member 5	Homo sapiens	77-81
10840050-5	2000	In polarized Madin-Darby canine kidney II (MDCKII) cells transfected with an MRP5 cDNA construct, MRP5 is routed to the basolateral membrane and these cells transport S-(2,4-dinitrophenyl)glutathione and glutathione preferentially toward the basal compartment.	S-(2,4-dinitrophenyl)glutathione	167-199	ATP binding cassette subfamily C member 5	Homo sapiens	98-102
10794730-4	2000	Mrp2 activity was assessed in the isolated perfused rat liver by measuring the excretion of dinitrophenyl-S-glutathione as a substrate of Mrp2.	S-(2,4-dinitrophenyl)glutathione	92-119	ATP binding cassette subfamily B member 4	Rattus norvegicus	0-4
10794730-4	2000	Mrp2 activity was assessed in the isolated perfused rat liver by measuring the excretion of dinitrophenyl-S-glutathione as a substrate of Mrp2.	S-(2,4-dinitrophenyl)glutathione	92-119	ATP binding cassette subfamily B member 4	Rattus norvegicus	138-142
12545192-2	2002	RLIP76 is a non-ATP binding cassette (ABC) protein but it has two ATP-binding sites and shows basal ATPase activity which is stimulated in the presence of its transport substrates (allocrites) such as doxorubicin (DOX) and S-(2,4-dinitrophenyl) glutathione (DNP-SG).	S-(2,4-dinitrophenyl)glutathione	223-256	ralA binding protein 1	Homo sapiens	0-6
12545192-2	2002	RLIP76 is a non-ATP binding cassette (ABC) protein but it has two ATP-binding sites and shows basal ATPase activity which is stimulated in the presence of its transport substrates (allocrites) such as doxorubicin (DOX) and S-(2,4-dinitrophenyl) glutathione (DNP-SG).	S-(2,4-dinitrophenyl)glutathione	258-264	ralA binding protein 1	Homo sapiens	0-6
11737211-3	2001	This paper shows that transport of the model substrate, 3 microm dinitrophenyl S-glutathione, across erythrocyte membranes is inhibited by multidrug resistance-associated protein 1 (MRP1)-specific antibody, QCRL-3, strongly suggesting that the high affinity transport is mediated by MRP1.	S-(2,4-dinitrophenyl)glutathione	65-92	ATP binding cassette subfamily C member 1	Homo sapiens	139-180
11737211-3	2001	This paper shows that transport of the model substrate, 3 microm dinitrophenyl S-glutathione, across erythrocyte membranes is inhibited by multidrug resistance-associated protein 1 (MRP1)-specific antibody, QCRL-3, strongly suggesting that the high affinity transport is mediated by MRP1.	S-(2,4-dinitrophenyl)glutathione	65-92	ATP binding cassette subfamily C member 1	Homo sapiens	182-186
11737211-3	2001	This paper shows that transport of the model substrate, 3 microm dinitrophenyl S-glutathione, across erythrocyte membranes is inhibited by multidrug resistance-associated protein 1 (MRP1)-specific antibody, QCRL-3, strongly suggesting that the high affinity transport is mediated by MRP1.	S-(2,4-dinitrophenyl)glutathione	65-92	ATP binding cassette subfamily C member 1	Homo sapiens	283-287
11641421-8	2001	Inhibition studies indicated that intracellular formation of S-(2,4-dinitrophenyl)-glutathione from 2,4-chlorodinitrobenzene selectively inhibits the transcellular transport of [(3)H]BSP at the site of MRP2-mediated export.	S-(2,4-dinitrophenyl)glutathione	61-94	ATP binding cassette subfamily C member 2	Canis lupus familiaris	202-206
10720481-8	2000	Sharp increase in the static quenching occurs for apo-alpha-LA and holo-alpha-LA above 1.5 M GDN/HCl and 3.5 M GDN/HCl, respectively.	S-(2,4-dinitrophenyl)glutathione	93-96	lactalbumin alpha	Homo sapiens	54-62
10720481-8	2000	Sharp increase in the static quenching occurs for apo-alpha-LA and holo-alpha-LA above 1.5 M GDN/HCl and 3.5 M GDN/HCl, respectively.	S-(2,4-dinitrophenyl)glutathione	93-96	lactalbumin alpha	Homo sapiens	72-80
10720481-8	2000	Sharp increase in the static quenching occurs for apo-alpha-LA and holo-alpha-LA above 1.5 M GDN/HCl and 3.5 M GDN/HCl, respectively.	S-(2,4-dinitrophenyl)glutathione	111-114	lactalbumin alpha	Homo sapiens	54-62
10720481-8	2000	Sharp increase in the static quenching occurs for apo-alpha-LA and holo-alpha-LA above 1.5 M GDN/HCl and 3.5 M GDN/HCl, respectively.	S-(2,4-dinitrophenyl)glutathione	111-114	lactalbumin alpha	Homo sapiens	72-80
10720481-9	2000	The results for apo-alpha-LA in dilute GDN/HCl suggest that acrylamide can penetrate the protein molecule (as judged by the collision quenching) but is unable to form a stable complex within the quenching domain for the tryptophans (as judged by the absence of the static quench constant).	S-(2,4-dinitrophenyl)glutathione	39-42	lactalbumin alpha	Homo sapiens	20-28
10101137-5	1999	Similarly, there was also much lower inhibition of the ATP-dependent uptake of S-(2,4-dinitrophenyl)-glutathione, a substrate of cMOAT, by the above compounds.	S-(2,4-dinitrophenyl)glutathione	79-112	ATP binding cassette subfamily C member 2	Rattus norvegicus	129-134
10359813-5	1999	In Madin-Darby canine kidney II cells, MRP3 routes to the basolateral membrane and mediates transport of the organic anion S-(2,4-dinitrophenyl-)glutathione toward the basolateral side of the monolayer.	S-(2,4-dinitrophenyl)glutathione	123-156	ATP binding cassette subfamily C member 3	Homo sapiens	39-43
10570049-8	1999	LTC(4) and S-(2, 4-dinitrophenyl)glutathione were actively transported into membrane vesicles prepared from LLC/cMOAT-1 cells.	S-(2,4-dinitrophenyl)glutathione	11-44	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	112-117
10079207-1	1999	We have recently demonstrated mutually inhibitory ATP-dependent transport of dinitrophenyl-S-glutathione (DNP-SG) and doxorubicin by DNP-SG ATPase purified from human erythrocyte membranes (S. Awasthi et al., 1998a,b).	S-(2,4-dinitrophenyl)glutathione	77-104	ATPase phospholipid transporting 8A2	Homo sapiens	50-53
10363583-3	1999	Membrane vesicles isolated from C-A500 and KCP-4, but not from KB-3-1, exhibited the ATP-dependent uptake of glutathione conjugates (GS-X) such as leukotriene C4 and 2,4-dinitrophenyl-S-glutathione (DNP-SG), indicating the presence of GS-X pumps on these cells.	S-(2,4-dinitrophenyl)glutathione	199-205	ATP binding cassette subfamily C member 1	Homo sapiens	133-137
10077229-1	1999	Multidrug resistance-associated protein (MRP) has been shown to transport glutathione (GSH) S-conjugates such as leukotriene C4 (LTC4) and S-(2,4-dinitrophenyl)-glutathione (DNP-SG).	S-(2,4-dinitrophenyl)glutathione	139-172	ATP binding cassette subfamily C member 3	Homo sapiens	0-39
10024515-10	1999	In membrane vesicles isolated from cMOAT-expressing MDCKII cells, ATP-dependent S-(2,4-dinitrophenyl)glutathione uptake is competitively inhibited by high concentrations of GSH (Ki approximately 20 mM).	S-(2,4-dinitrophenyl)glutathione	80-112	ATP binding cassette subfamily C member 2	Homo sapiens	35-40
10077229-1	1999	Multidrug resistance-associated protein (MRP) has been shown to transport glutathione (GSH) S-conjugates such as leukotriene C4 (LTC4) and S-(2,4-dinitrophenyl)-glutathione (DNP-SG).	S-(2,4-dinitrophenyl)glutathione	139-172	ATP binding cassette subfamily C member 3	Homo sapiens	41-44
10077229-1	1999	Multidrug resistance-associated protein (MRP) has been shown to transport glutathione (GSH) S-conjugates such as leukotriene C4 (LTC4) and S-(2,4-dinitrophenyl)-glutathione (DNP-SG).	S-(2,4-dinitrophenyl)glutathione	174-180	ATP binding cassette subfamily C member 3	Homo sapiens	0-39
10077229-1	1999	Multidrug resistance-associated protein (MRP) has been shown to transport glutathione (GSH) S-conjugates such as leukotriene C4 (LTC4) and S-(2,4-dinitrophenyl)-glutathione (DNP-SG).	S-(2,4-dinitrophenyl)glutathione	174-180	ATP binding cassette subfamily C member 3	Homo sapiens	41-44
9729482-4	1998	ATP-dependent [3H]GSH transport was cis-inhibited by substrates of the yeast YCF1 transporter, including sulphobromophthalein, glutathione S-conjugates and the alkaloid verapamil, and was competitively inhibited by S-(2, 4-dinitrophenyl)glutathione (DNP-SG).	S-(2,4-dinitrophenyl)glutathione	215-248	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	77-81
9756510-5	1998	This ATP-dependent uptake was saturable with a Michaelis constant (Km) value of 126 microM, which was comparable with its inhibitor constant (Ki) value of 121 microM for the ATP-dependent uptake of a typical cMOAT substrate, 2,4-dinitrophenyl-S-glutathione (DNP-SG).	S-(2,4-dinitrophenyl)glutathione	258-264	ATP binding cassette subfamily C member 2	Rattus norvegicus	208-213
9525973-6	1998	We demonstrate that cMOAT causes transport of the organic anions S-(2,4-dinitrophenyl)-glutathione, the glutathione conjugate of ethacrynic acid, and S-(PGA1)-glutathione, a substrate not shown to be transported by organic anion transporters previously.	S-(2,4-dinitrophenyl)glutathione	65-98	ATP binding cassette subfamily C member 2	Homo sapiens	20-25
9321514-9	1997	ATP-dependent uptake of 2, 4-dinitrophenyl glutathione, a typical substrate for the canalicular multispecific organic anion transporter (cMOAT), was inhibited by pravastatin in a concentration-dependent manner and the resultant inhibitory constant of pravastatin (170 microM) was comparable with the KM value of ATP-dependent pravastatin uptake itself.	S-(2,4-dinitrophenyl)glutathione	24-54	ATP binding cassette subfamily C member 2	Rattus norvegicus	84-135
9321514-9	1997	ATP-dependent uptake of 2, 4-dinitrophenyl glutathione, a typical substrate for the canalicular multispecific organic anion transporter (cMOAT), was inhibited by pravastatin in a concentration-dependent manner and the resultant inhibitory constant of pravastatin (170 microM) was comparable with the KM value of ATP-dependent pravastatin uptake itself.	S-(2,4-dinitrophenyl)glutathione	24-54	ATP binding cassette subfamily C member 2	Rattus norvegicus	137-142
9188796-11	1997	A substrate binding site on MRP is proposed that comprises a pocket in which both DNR and GS-DNP or GSSG bind in random order to different, only partly overlapping sites.	S-(2,4-dinitrophenyl)glutathione	90-96	ATP binding cassette subfamily C member 1	Homo sapiens	28-31
9280310-2	1997	In this study we report that dinitrophenyl-S-glutathione increases ATPase activity in plasma membrane vesicles prepared from the MRP-overexpressing cell line GLC4/ADR.	S-(2,4-dinitrophenyl)glutathione	29-56	ATP binding cassette subfamily C member 1	Homo sapiens	129-132
9280310-2	1997	In this study we report that dinitrophenyl-S-glutathione increases ATPase activity in plasma membrane vesicles prepared from the MRP-overexpressing cell line GLC4/ADR.	S-(2,4-dinitrophenyl)glutathione	29-56	aldo-keto reductase family 1 member B	Homo sapiens	163-166
8950226-12	1996	It is possible that ethacrynic acid also inhibits the transport of DNPSG by inhibition of the multidrug resistance-associated protein gene encoding glutathione conjugate export pump (MRP/GS-X pump) in some way.	S-(2,4-dinitrophenyl)glutathione	67-72	ATP binding cassette subfamily C member 3	Homo sapiens	94-133
8950226-2	1996	The glutathione S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene in intact human IGR-39 melanoma cells was determined by the quantification by HPLC-analysis of the excreted glutathione (GSH) conjugate (S-(2,4-dinitrophenyl)glutathione; DNPSG).	S-(2,4-dinitrophenyl)glutathione	218-250	glutathione S-transferase kappa 1	Homo sapiens	4-29
8950226-12	1996	It is possible that ethacrynic acid also inhibits the transport of DNPSG by inhibition of the multidrug resistance-associated protein gene encoding glutathione conjugate export pump (MRP/GS-X pump) in some way.	S-(2,4-dinitrophenyl)glutathione	67-72	ATP binding cassette subfamily C member 1	Homo sapiens	183-186
8950226-2	1996	The glutathione S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene in intact human IGR-39 melanoma cells was determined by the quantification by HPLC-analysis of the excreted glutathione (GSH) conjugate (S-(2,4-dinitrophenyl)glutathione; DNPSG).	S-(2,4-dinitrophenyl)glutathione	218-250	glutathione S-transferase kappa 1	Homo sapiens	31-34
8950226-12	1996	It is possible that ethacrynic acid also inhibits the transport of DNPSG by inhibition of the multidrug resistance-associated protein gene encoding glutathione conjugate export pump (MRP/GS-X pump) in some way.	S-(2,4-dinitrophenyl)glutathione	67-72	ATP binding cassette subfamily C member 1	Homo sapiens	187-191
8950226-2	1996	The glutathione S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene in intact human IGR-39 melanoma cells was determined by the quantification by HPLC-analysis of the excreted glutathione (GSH) conjugate (S-(2,4-dinitrophenyl)glutathione; DNPSG).	S-(2,4-dinitrophenyl)glutathione	252-257	glutathione S-transferase kappa 1	Homo sapiens	4-29
8950226-2	1996	The glutathione S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene in intact human IGR-39 melanoma cells was determined by the quantification by HPLC-analysis of the excreted glutathione (GSH) conjugate (S-(2,4-dinitrophenyl)glutathione; DNPSG).	S-(2,4-dinitrophenyl)glutathione	252-257	glutathione S-transferase kappa 1	Homo sapiens	31-34
8692921-11	1996	The broad substrate specificity of MRP was confirmed by the observation that daunorubicin transport was competitively inhibited by reduced and oxidized glutathione, the glutathione conjugates S-(p-azidophenacyl)-glutathione (APA-SG) and S-(2,4-dinitrophenyl)glutathione (DNP-SG), arsenate, and the LTD4 antagonist MK571.	S-(2,4-dinitrophenyl)glutathione	239-269	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	35-38
8950226-9	1996	Reversible inhibition of GST was the major mechanism of inhibition of DNPSG-excretion in melanoma cells, except in the cases of curcumin and ethacrynic acid, which compounds also inactivated GSTP1-1 by covalent modification.	S-(2,4-dinitrophenyl)glutathione	70-75	glutathione S-transferase kappa 1	Homo sapiens	25-28
8636432-5	1996	In accordance with this localization, MRP caused increased transport of the glutathione S-conjugate S-(2, 4-dinitrophenyl)-glutathione and of the anticancer drug daunorubicin to the basal side of the epithelial cell layer.	S-(2,4-dinitrophenyl)glutathione	100-134	ATP binding cassette subfamily C member 1	Homo sapiens	38-41
8595394-1	1995	Tert-Butyl hydroperoxide (100-300 microM) was found to inhibit the active efflux of dinitrophenyl-S-glutathione (DNP-SG) from human erythrocytes.	S-(2,4-dinitrophenyl)glutathione	84-111	telomerase reverse transcriptase	Homo sapiens	0-4
1566846-5	1992	ATP-dependent BSP transport was inhibited by oxidized glutathione, dinitrophenyl-glutathione (GSDNP), BSP glutathione, and bilirubin diglucuronide but not by daunomycin, taurocholate, and reduced glutathione.	S-(2,4-dinitrophenyl)glutathione	94-99	integrin-binding sialoprotein	Rattus norvegicus	14-17
7768511-5	1995	The appearance of intracellular cMOAT activity coincides with the disappearance of 70% of cMOAT activity from the plasma membrane as measured by the transport activity of the cells for the organic anion dinitrophenyl-glutathione (GS-DNP).	S-(2,4-dinitrophenyl)glutathione	230-236	ATP binding cassette subfamily C member 2	Rattus norvegicus	32-37
7768511-5	1995	The appearance of intracellular cMOAT activity coincides with the disappearance of 70% of cMOAT activity from the plasma membrane as measured by the transport activity of the cells for the organic anion dinitrophenyl-glutathione (GS-DNP).	S-(2,4-dinitrophenyl)glutathione	230-236	ATP binding cassette subfamily C member 2	Rattus norvegicus	90-95
2036430-7	1991	The AP-2 complex was also completely dissociated in a highly denaturing solvent, 6 M Gdn.HCl, and the constituent subunits of 100-115, 50, and 16 kDa were separated by gel filtration.	S-(2,4-dinitrophenyl)glutathione	85-88	transcription factor AP-2 alpha	Homo sapiens	4-8
2143605-1	1990	An ATP-dependent transport process for S-(2,4-dinitrophenyl) glutathione (Dnp-SG) mediated by a novel ATPase designated as Dnp-SG ATPase has been demonstrated in human erythrocytes (LaBelle et al., FEBS Lett.	S-(2,4-dinitrophenyl)glutathione	39-72	ralA binding protein 1	Homo sapiens	123-136