PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24841903-6	2014	Screening of 3,360 compounds identified rutilantin, ethacridine lactate and cetalkonium chloride as compounds that selectively target PC3 control cells and a tilorone analog as a selective inhibitor of PC3 CDK5dn cells.	Ethacridine	52-71	chromobox 8	Homo sapiens	134-137
22901761-3	2012	Furthermore, the efficient digestion of apo A-1 by trypsin was inhibited when HDL was treated with membrane-immobilized esterase in the presence of an esterase inhibitor, 6,9-diamino-2-ethoxyacridine (acrinol).	Ethacridine	171-199	apolipoprotein A1	Homo sapiens	40-47
22901761-3	2012	Furthermore, the efficient digestion of apo A-1 by trypsin was inhibited when HDL was treated with membrane-immobilized esterase in the presence of an esterase inhibitor, 6,9-diamino-2-ethoxyacridine (acrinol).	Ethacridine	201-208	apolipoprotein A1	Homo sapiens	40-47
1534279-1	1992	Transferrin subtypes were determined by isoelectric focusing (IEF) and a special treatment of sera with Rivanol- ferrous ammonium sulfate (FAS) in a total of 2121 individuals from 11 southern minority populations in China, including Hani minority (217), Buyi minority (209), Tujia minority (168), Miao minority (197), Zhuang minority (171), Yao minority (210), Bai minority (178), Dong minority (157), Yi minority (206), Qiang minority (219) and Li minority (189).	Ethacridine	104-111	transferrin	Homo sapiens	0-11
1708670-4	1990	PAI-2, which is precipitated by low Rivanol concentrations, can be selectively redissolved from the pellet by increasing the Rivanol concentration in the presence of a reducing agent, i.e. dithiothreitol.	Ethacridine	36-43	serpin family B member 2	Homo sapiens	0-5
1708670-4	1990	PAI-2, which is precipitated by low Rivanol concentrations, can be selectively redissolved from the pellet by increasing the Rivanol concentration in the presence of a reducing agent, i.e. dithiothreitol.	Ethacridine	125-132	serpin family B member 2	Homo sapiens	0-5
3501295-2	1987	Human protein C-inhibitor (PCI) was isolated from human citrated plasma by combining rivanol precipitation, ammonium sulfate precipitation, ion-exchange chromatography on DEAE-Sephacel and affinity chromatography on dextran sulfate Sepharose.	Ethacridine	85-92	serpin family A member 5	Homo sapiens	6-25
2458817-8	1988	Feline transferrin was precipitated with Rivanol.	Ethacridine	41-48	transferrin	Homo sapiens	7-18
3501295-2	1987	Human protein C-inhibitor (PCI) was isolated from human citrated plasma by combining rivanol precipitation, ammonium sulfate precipitation, ion-exchange chromatography on DEAE-Sephacel and affinity chromatography on dextran sulfate Sepharose.	Ethacridine	85-92	serpin family A member 5	Homo sapiens	27-30
6781170-4	1980	APTT was elevated at the time of abortion, and both prothrombin as well as fibrin were elevated 24 hours after expulsion in response to rivanol-induced abortion.	Ethacridine	136-143	coagulation factor II, thrombin	Homo sapiens	52-63
6545995-1	1984	By the method of precipitation with Rivanol (2-ethoxy-6,9-diaminoacridine lactate) and ammonium sulphate followed by chromatography on DEAE cellulose three genetic variants of transferrin were purified from equine serum: D, M and R. Their molecular mass determined in this study was 80 000, and it was identical for all three variants, which differed slightly in their amino acid composition.	Ethacridine	36-43	inhibitor of carbonic anhydrase	Equus caballus	176-187
7445879-4	1980	The active areas of the Fab fragment of IgG are blocked on the erythrocytic surface, which constitutes an important feature of sensitization by means of rivanol.	Ethacridine	153-160	FA complementation group B	Homo sapiens	24-27
517109-1	1979	15-Hydroxy-prostaglandin-dehydrogenase was purified 3 to 5 fold and with almost 100% yield from swine lungs by a novel method of precipitation with Rivanol after which it was further purified (8-10 fold) by gel-filtration.	Ethacridine	148-155	carbonyl reductase [NADPH] 1	Sus scrofa	0-38
441424-0	1979	Lysozyme in amniotic fluid during rivanol-induced second trimester abortion.	Ethacridine	34-41	lysozyme	Homo sapiens	0-8
332055-1	1977	Three human transferrin variants verified by rivanol precipitation were separated using vertical block polyacrylamide gel electrophoresis followed by elution convection.	Ethacridine	45-52	transferrin	Homo sapiens	12-23
575002-2	1979	In rivanol-soluble IgG, enrichment in IgG3 carrying Gm5 antigen was demonstrated and, in a preparation fractionated by DEAE-Sephadex chromatography, molecules with a predominantly Gml-expressed antigen were shown to be present.	Ethacridine	3-10	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	38-42
1182212-1	1975	Rat hemopexin was purified by a procedure involving three different steps : ammonium sulfate precipitation, rivanol precipitation and DEAE-cellulose chromatography with concave gradient of molarity.	Ethacridine	108-115	hemopexin	Rattus norvegicus	4-13
4128754-0	1973	Letter: Rivanol counterelectrophoresis compared with radioimmunoassay for the detection of alpha-fetoprotein.	Ethacridine	8-15	alpha fetoprotein	Homo sapiens	91-108
4423843-0	1974	The rivanol method for the quantitative determination of antithrombin III in plasma.	Ethacridine	4-11	serpin family C member 1	Homo sapiens	57-73
4173192-0	1968	[Quantitative determination of serum haptoglobin by the rivanol method].	Ethacridine	56-63	haptoglobin	Homo sapiens	37-48
4174438-0	1968	The application of rivanol for serum transferrin and immunoglobulin G determination.	Ethacridine	19-26	transferrin	Homo sapiens	37-48
32345138-3	2020	We previously reported that the small molecule ethacridine, identified as a TAZ activator, was able to induce thyroid specific transcription in endodermal cells differentiated from human embryonic stem (hES) cells using activin A.	Ethacridine	47-58	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	76-79
13750875-0	1961	The interaction of rivanol with bovine serum albumin.	Ethacridine	19-26	albumin	Homo sapiens	39-52
13756425-0	1960	[Human siderophilin: isolation from blood plasma and plasma fractions by rivanol, analytical determination and crystallization].	Ethacridine	73-80	transferrin	Homo sapiens	7-19
32345138-6	2020	RESULTS: ATAC-seq analysis showed enriched chromatin accessibility of TAZ, NKX2-1 and PAX8 after exposure to activin A and ethacridine.	Ethacridine	123-134	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	70-73
32345138-6	2020	RESULTS: ATAC-seq analysis showed enriched chromatin accessibility of TAZ, NKX2-1 and PAX8 after exposure to activin A and ethacridine.	Ethacridine	123-134	NK2 homeobox 1	Homo sapiens	75-81
33140048-3	2020	Here we report that ethacridine, a safe and potent antiseptic use in humans, effectively inhibits SARS-CoV-2, at very low concentrations (EC 50 ~ 0.08 mu M).	Ethacridine	20-31	membrane glycoprotein	Severe acute respiratory syndrome coronavirus 2	154-155
32345138-6	2020	RESULTS: ATAC-seq analysis showed enriched chromatin accessibility of TAZ, NKX2-1 and PAX8 after exposure to activin A and ethacridine.	Ethacridine	123-134	paired box 8	Homo sapiens	86-90
27829313-7	2017	Following further differentiation with the combination of ethacridine and TSH, the thyroid-specific genes TG, TPO, TSHR, and NIS were all induced in the differentiated hES cells.	Ethacridine	58-69	thyroid peroxidase	Homo sapiens	110-113
32760346-7	2020	Definitive endoderm cells were induced with activin A and the transcription factor TAZ was significantly induced on ethacridine treatment and translocated to the nucleus.	Ethacridine	116-127	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	83-86
32760346-8	2020	Thyroid transcription factors NKX2-1 and PAX8 were also highly expressed in activin A derived endoderm cells and further induced by ethacridine.	Ethacridine	132-143	NK2 homeobox 1	Homo sapiens	30-36
32760346-8	2020	Thyroid transcription factors NKX2-1 and PAX8 were also highly expressed in activin A derived endoderm cells and further induced by ethacridine.	Ethacridine	132-143	paired box 8	Homo sapiens	41-45
31366493-2	2019	Recent studies showed that ethacridine is an inhibitor of poly(ADP-ribose) glycohydrolase (PARG) and an activator of the transcriptional coactivator with PDZ-binding motif (TAZ).	Ethacridine	27-38	poly(ADP-ribose) glycohydrolase	Homo sapiens	58-89
31366493-2	2019	Recent studies showed that ethacridine is an inhibitor of poly(ADP-ribose) glycohydrolase (PARG) and an activator of the transcriptional coactivator with PDZ-binding motif (TAZ).	Ethacridine	27-38	poly(ADP-ribose) glycohydrolase	Homo sapiens	91-95
29650538-8	2018	Chimera between proflavine-sensitive Kir1.1 and -insensitive Kir4.1 revealed that the extracellular portion of Kir1.1 is crucial for the recognition of the proflavine derivative acrinol.	Ethacridine	178-185	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	37-43
29650538-8	2018	Chimera between proflavine-sensitive Kir1.1 and -insensitive Kir4.1 revealed that the extracellular portion of Kir1.1 is crucial for the recognition of the proflavine derivative acrinol.	Ethacridine	178-185	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	61-67
29650538-8	2018	Chimera between proflavine-sensitive Kir1.1 and -insensitive Kir4.1 revealed that the extracellular portion of Kir1.1 is crucial for the recognition of the proflavine derivative acrinol.	Ethacridine	178-185	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	111-117
27829313-7	2017	Following further differentiation with the combination of ethacridine and TSH, the thyroid-specific genes TG, TPO, TSHR, and NIS were all induced in the differentiated hES cells.	Ethacridine	58-69	thyroid stimulating hormone receptor	Homo sapiens	115-119
26624983-4	2016	Using a high-throughput combination chemical screen, we identified that the poly(ADP-ribose) glycohydrolase (PARG) inhibitor ethacridine lactate synergized with ibrutinib in TEX and OCI-AML2 leukemia cell lines.	Ethacridine	125-144	poly(ADP-ribose) glycohydrolase	Homo sapiens	76-107
26624983-4	2016	Using a high-throughput combination chemical screen, we identified that the poly(ADP-ribose) glycohydrolase (PARG) inhibitor ethacridine lactate synergized with ibrutinib in TEX and OCI-AML2 leukemia cell lines.	Ethacridine	125-144	poly(ADP-ribose) glycohydrolase	Homo sapiens	109-113
25979969-0	2015	A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells.	Ethacridine	53-64	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	27-30
25979969-0	2015	A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells.	Ethacridine	53-64	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	159-162
25979969-9	2015	We unexpectedly found that ethacridine, a widely used antiseptic and abortifacient, enhances the interaction of TAZ and protein phosphatases and increases unphosphorylated and nuclear TAZ.	Ethacridine	27-38	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	112-115
25979969-9	2015	We unexpectedly found that ethacridine, a widely used antiseptic and abortifacient, enhances the interaction of TAZ and protein phosphatases and increases unphosphorylated and nuclear TAZ.	Ethacridine	27-38	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	184-187
25979969-10	2015	Ethacridine inhibits adipogenesis in mesenchymal C3H10T1/2 cells through the activation of TAZ.	Ethacridine	0-11	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	91-94
25979969-11	2015	This finding suggests that ethacridine is a bona fide TAZ activator and supports that our assay is useful to discover TAZ activators.	Ethacridine	27-38	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	54-57
25979969-11	2015	This finding suggests that ethacridine is a bona fide TAZ activator and supports that our assay is useful to discover TAZ activators.	Ethacridine	27-38	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	118-121