PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8603747-6	1996	Second, the activation by diacylglycerol is not stereospecific, in marked contrast to the specificity for 1,2-diacyl-sn-glycerol in the activation of protein kinase C. Because circulating levels of insulin are below the Kd of the insulin receptor for insulin, the ability of diacylglycerol to modulate the affinity of the receptor for ligand suggests that increases in cellular levels of diacylglycerol directly sensitize the receptor to insulin.	1,2-diacyl-sn-glycerol	106-128	insulin	Homo sapiens	198-205
15125969-1	2004	We have designed novel PKC ligands having an isobenzofuranone template, based on the proposed interaction of DAG (1,2-diacyl-sn-glycerol) with the PKCdelta C1B ligand-binding domain.	1,2-diacyl-sn-glycerol	114-136	protein kinase C alpha	Homo sapiens	23-26
15134488-1	2004	Protein kinase C (PKC) isozymes (alpha, betaI, betaII, gamma, delta, epsilon, eta, theta) are major receptors of tumor promoters and also play a crucial role in cellular signal transduction via the second messenger, 1,2-diacyl-sn-glycerol (DG).	1,2-diacyl-sn-glycerol	216-238	endothelin receptor type A	Homo sapiens	41-44
12738994-7	2003	Addition of phorbol 12-myristate 13-acetate, 1,2-diacyl-sn-glycerol, IFN-gamma, or IFN-alpha induced the expression of TFPI-2 wild-type promoter construct as well as TFPI-2 protein and mRNA in Hs683 cells.	1,2-diacyl-sn-glycerol	45-67	tissue factor pathway inhibitor 2	Homo sapiens	119-125
12738994-7	2003	Addition of phorbol 12-myristate 13-acetate, 1,2-diacyl-sn-glycerol, IFN-gamma, or IFN-alpha induced the expression of TFPI-2 wild-type promoter construct as well as TFPI-2 protein and mRNA in Hs683 cells.	1,2-diacyl-sn-glycerol	45-67	tissue factor pathway inhibitor 2	Homo sapiens	166-172
11352745-1	2001	Phorbol ester-induced conventional protein kinase C (PKCalpha, -betaIota/IotaIota, and -gamma) isozyme activities are potentiated by 1,2-diacyl-sn-glycerol.	1,2-diacyl-sn-glycerol	133-155	protein kinase C alpha	Homo sapiens	53-61
10320809-7	1999	In the sn-1 to -1(3) transfer, the sn-1 acyl residue of 1-acyl-sn-glycero-3-phosphocholine was transferred to the sn-1(3) positions of glycerol and 2-acyl-sn-glycerol, producing 1(3)-acyl-sn-glycerol and 1,2-diacyl-sn-glycerol, respectively.	1,2-diacyl-sn-glycerol	204-226	heterogeneous nuclear ribonucleoprotein U	Rattus norvegicus	7-17
9731508-4	1998	Here, we show that the level of MGMT mRNA in HeLa S3 cells was increased 3-5-fold by phorbol-12-myristate-13-acetate (TPA) and 1,2-diacyl-sn-glycerol (DAG), which are activators of protein kinase C (PKC), as well as by okadaic acid, an inhibitor of protein phosphatases.	1,2-diacyl-sn-glycerol	127-149	O-6-methylguanine-DNA methyltransferase	Homo sapiens	32-36
8603747-6	1996	Second, the activation by diacylglycerol is not stereospecific, in marked contrast to the specificity for 1,2-diacyl-sn-glycerol in the activation of protein kinase C. Because circulating levels of insulin are below the Kd of the insulin receptor for insulin, the ability of diacylglycerol to modulate the affinity of the receptor for ligand suggests that increases in cellular levels of diacylglycerol directly sensitize the receptor to insulin.	1,2-diacyl-sn-glycerol	106-128	insulin receptor	Homo sapiens	230-246
8603747-6	1996	Second, the activation by diacylglycerol is not stereospecific, in marked contrast to the specificity for 1,2-diacyl-sn-glycerol in the activation of protein kinase C. Because circulating levels of insulin are below the Kd of the insulin receptor for insulin, the ability of diacylglycerol to modulate the affinity of the receptor for ligand suggests that increases in cellular levels of diacylglycerol directly sensitize the receptor to insulin.	1,2-diacyl-sn-glycerol	106-128	insulin	Homo sapiens	230-237
8603747-6	1996	Second, the activation by diacylglycerol is not stereospecific, in marked contrast to the specificity for 1,2-diacyl-sn-glycerol in the activation of protein kinase C. Because circulating levels of insulin are below the Kd of the insulin receptor for insulin, the ability of diacylglycerol to modulate the affinity of the receptor for ligand suggests that increases in cellular levels of diacylglycerol directly sensitize the receptor to insulin.	1,2-diacyl-sn-glycerol	106-128	insulin	Homo sapiens	230-237
2405021-1	1990	Recent evidence has suggested that pancreatic islets isolated from rats synthesize 1,2-diacyl-sn-glycerol (DAG) de novo from glucose and that this process may constitute the long-sought link between the metabolism of glucose and the induction of insulin secretion.	1,2-diacyl-sn-glycerol	83-105	insulin	Homo sapiens	246-253
6277612-1	1982	Phosphatidic acid phosphatase (PAPase) which catalyzes the conversion of phosphatidic acid to 1,2-diacyl-sn-glycerol was studied in fetal, neonatal, and adult rat lung microsomal fractions from whole lung under normal and altered physiological states.	1,2-diacyl-sn-glycerol	94-116	ubiquitin-conjugating enzyme E2D 3	Rattus norvegicus	0-29
6277612-1	1982	Phosphatidic acid phosphatase (PAPase) which catalyzes the conversion of phosphatidic acid to 1,2-diacyl-sn-glycerol was studied in fetal, neonatal, and adult rat lung microsomal fractions from whole lung under normal and altered physiological states.	1,2-diacyl-sn-glycerol	94-116	ubiquitin-conjugating enzyme E2D 3	Rattus norvegicus	31-37
2153111-2	1990	The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied.	1,2-diacyl-sn-glycerol	190-212	cut-like homeobox 1	Rattus norvegicus	85-88
2153111-2	1990	The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied.	1,2-diacyl-sn-glycerol	190-212	cut-like homeobox 1	Rattus norvegicus	177-180
3534892-0	1986	Identification of the parasite transferrin receptor of Plasmodium falciparum-infected erythrocytes and its acylation via 1,2-diacyl-sn-glycerol.	1,2-diacyl-sn-glycerol	121-143	transferrin	Homo sapiens	31-42
3534892-6	1986	Preliminary analysis indicated that, unlike the human receptor, the plasmodial transferrin receptor is not a disulfide linked dimer but a single polypeptide acylated via 1,2-diacyl-sn-glycerol.	1,2-diacyl-sn-glycerol	170-192	transferrin	Homo sapiens	79-90
6256494-1	1980	Highly purified rat brain myelin isolated by two different procedures showed appreciable activity for CDP-ethanolamine: 1,2-diacyl-sn-glycerol ethanolaminephosphotransferase (EC 2.7.8.1).	1,2-diacyl-sn-glycerol	120-142	cut-like homeobox 1	Rattus norvegicus	102-105