PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28978997-12	2017	Especially the use of cystatin C renders the addition of BTP unnecessary.	2,6-bis(1,2,3-triazol-4-yl)pyridine	57-60	cystatin C	Homo sapiens	22-32
30631864-6	2019	However, Car1 and Car2 evidently emitted at around 450 nm in solution at 77 K, invoked by radiative ICT transitions between the carborane and the ppy or btp moiety, indicating that ICT-based radiative decay is only invigorated in the rigid state in the absence of structural variations, such as C-C bond fluctuations in the carborane cage and aromatic-ring free rotation.	2,6-bis(1,2,3-triazol-4-yl)pyridine	153-156	nuclear receptor subfamily 1 group I member 3	Homo sapiens	9-13
30631864-6	2019	However, Car1 and Car2 evidently emitted at around 450 nm in solution at 77 K, invoked by radiative ICT transitions between the carborane and the ppy or btp moiety, indicating that ICT-based radiative decay is only invigorated in the rigid state in the absence of structural variations, such as C-C bond fluctuations in the carborane cage and aromatic-ring free rotation.	2,6-bis(1,2,3-triazol-4-yl)pyridine	153-156	nuclear receptor subfamily 1 group I member 4	Homo sapiens	18-22
30631864-8	2019	DFT-optimised structures of Car1 and Car2 in their ground and the first-excited states clearly reveal that the enhanced emissive features of Car2 in the film state are strongly associated with the retained planarity of the btp moiety in both the ground and excited states.	2,6-bis(1,2,3-triazol-4-yl)pyridine	223-226	nuclear receptor subfamily 1 group I member 3	Homo sapiens	28-32
30631864-8	2019	DFT-optimised structures of Car1 and Car2 in their ground and the first-excited states clearly reveal that the enhanced emissive features of Car2 in the film state are strongly associated with the retained planarity of the btp moiety in both the ground and excited states.	2,6-bis(1,2,3-triazol-4-yl)pyridine	223-226	nuclear receptor subfamily 1 group I member 4	Homo sapiens	37-41
30631864-8	2019	DFT-optimised structures of Car1 and Car2 in their ground and the first-excited states clearly reveal that the enhanced emissive features of Car2 in the film state are strongly associated with the retained planarity of the btp moiety in both the ground and excited states.	2,6-bis(1,2,3-triazol-4-yl)pyridine	223-226	nuclear receptor subfamily 1 group I member 4	Homo sapiens	141-145
33964400-6	2021	Transcriptome analysis between phenotypically normal and abnormal BTP lambs demonstrated separate responses within the cAMP and PI3K signalling pathways towards CREB.	2,6-bis(1,2,3-triazol-4-yl)pyridine	66-69	cyclic AMP-responsive element-binding protein 1	Ovis aries	161-165
29509424-2	2018	The btp ligand, H3L, adopts a three-dimensional hydrogen bonding network in the crystalline state through a combination of carboxylic acid dimer and syn-anti-btp/carboxylic acid hydrogen bonding synthons.	2,6-bis(1,2,3-triazol-4-yl)pyridine	4-7	synemin	Homo sapiens	149-152
29509424-2	2018	The btp ligand, H3L, adopts a three-dimensional hydrogen bonding network in the crystalline state through a combination of carboxylic acid dimer and syn-anti-btp/carboxylic acid hydrogen bonding synthons.	2,6-bis(1,2,3-triazol-4-yl)pyridine	158-161	synemin	Homo sapiens	149-152
27465930-1	2016	Three porous organic polymers (POPs) containing H, COOMe, and COO(-) groups at 2,6-bis(1,2,3-triazol-4-yl)pyridyl (BTP) units (i.e., POP-1, POP-2, and POP-3, respectively) were prepared for the immobilization of metal nanoparticles (NPs).	2,6-bis(1,2,3-triazol-4-yl)pyridine	115-118	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	133-138
28660965-6	2017	It is shown that they have lower toxicity for tissues and cells, their phosphorescence intensities are 8.27-fold that of BTP polyiohexol NPs (BPI NPs), the average phosphorescence intensity of the BAPI NPs was 1.46 times higher than that of BPI NPs and 5.85 times that of BTP alone in vivo.	2,6-bis(1,2,3-triazol-4-yl)pyridine	121-124	bactericidal permeability increasing protein	Homo sapiens	142-145
27465930-1	2016	Three porous organic polymers (POPs) containing H, COOMe, and COO(-) groups at 2,6-bis(1,2,3-triazol-4-yl)pyridyl (BTP) units (i.e., POP-1, POP-2, and POP-3, respectively) were prepared for the immobilization of metal nanoparticles (NPs).	2,6-bis(1,2,3-triazol-4-yl)pyridine	115-118	pyrin domain containing 2	Homo sapiens	140-145
27465930-1	2016	Three porous organic polymers (POPs) containing H, COOMe, and COO(-) groups at 2,6-bis(1,2,3-triazol-4-yl)pyridyl (BTP) units (i.e., POP-1, POP-2, and POP-3, respectively) were prepared for the immobilization of metal nanoparticles (NPs).	2,6-bis(1,2,3-triazol-4-yl)pyridine	115-118	pyrin domain containing 5	Homo sapiens	151-156
27465930-3	2016	The presence of carboxylate groups not only endows POP-3 an outstanding dispersibility in H2 O/EtOH, but also enables the palladium NPs at the surface to show the highest catalytic activity, stability, and recyclability in dehalogenation reactions of chlorobenzene at 25  C. The palladium NPs on the external surface are effectively stabilized by the functionalized POPs containing BTP units and carboxylate groups, which provides a new insight for highly efficient catalytic systems based on surface metal NPs of porous materials.	2,6-bis(1,2,3-triazol-4-yl)pyridine	382-385	pyrin domain containing 5	Homo sapiens	51-56
21825239-14	2011	CONCLUSIONS: These findings support the efficacy of DBS, with VIM and STN targets, in medically refractory BTP-related tremor.	2,6-bis(1,2,3-triazol-4-yl)pyridine	107-110	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	70-73
27295556-1	2016	We report the remarkable ability of 2,6-bis(1,2,3-triazol-4-yl)pyridine (btp) compounds 2 with appended olefin amide arms to self-template the formation of interlocked [2]catenane structures 3 in up to 50 % yield when subjected to olefin ring-closing metathesis in CH2 Cl2 .	2,6-bis(1,2,3-triazol-4-yl)pyridine	36-71	endogenous retrovirus group W member 5	Homo sapiens	269-272
27295556-1	2016	We report the remarkable ability of 2,6-bis(1,2,3-triazol-4-yl)pyridine (btp) compounds 2 with appended olefin amide arms to self-template the formation of interlocked [2]catenane structures 3 in up to 50 % yield when subjected to olefin ring-closing metathesis in CH2 Cl2 .	2,6-bis(1,2,3-triazol-4-yl)pyridine	73-76	endogenous retrovirus group W member 5	Homo sapiens	269-272
24071827-3	2013	The reaction between BTP and TiCl4 and ZrCl4 and HfCl4 in a 2 : 1 stoichiometric reaction resulted in the formation of disubstituted group IV chloride complexes L2MCl2 10-12 [L = (C1)BTP-H, M = Ti, Zr and Hf].	2,6-bis(1,2,3-triazol-4-yl)pyridine	21-24	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	180-188
19948240-4	2010	Using an affinity purification scheme to identify potential targets of BTP, we identified the actin reorganizing protein, drebrin, and demonstrated that loss of drebrin protein expression prevents store-operated channel mediated Ca(2+) entry, similar to BTP treatment.	2,6-bis(1,2,3-triazol-4-yl)pyridine	71-74	drebrin 1	Homo sapiens	122-129
20404049-6	2010	Store-operated Ca(2+) entry (SOCE) was elevated in HGF-treated EPCs, and the SOCC inhibitors 2-aminoethoxydiphenyl borate (2-APB) and BTP-2 inhibited the HGF-induced proliferation response.	2,6-bis(1,2,3-triazol-4-yl)pyridine	134-137	hepatocyte growth factor	Rattus norvegicus	154-157
19936622-9	2011	GTP and BTP supplementation as a sole source of drinking solution leads to scavenging of reactive oxygen species (ROS) (by ~72% and 69%, respectively) by inhibiting cyclooxygenase-2 (Cox-2) and inactivation of phosphorylated forms of nuclear factor-kappa B (NF-kappaB) and Akt.	2,6-bis(1,2,3-triazol-4-yl)pyridine	8-11	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	165-181
19936622-9	2011	GTP and BTP supplementation as a sole source of drinking solution leads to scavenging of reactive oxygen species (ROS) (by ~72% and 69%, respectively) by inhibiting cyclooxygenase-2 (Cox-2) and inactivation of phosphorylated forms of nuclear factor-kappa B (NF-kappaB) and Akt.	2,6-bis(1,2,3-triazol-4-yl)pyridine	8-11	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	183-188
19936622-9	2011	GTP and BTP supplementation as a sole source of drinking solution leads to scavenging of reactive oxygen species (ROS) (by ~72% and 69%, respectively) by inhibiting cyclooxygenase-2 (Cox-2) and inactivation of phosphorylated forms of nuclear factor-kappa B (NF-kappaB) and Akt.	2,6-bis(1,2,3-triazol-4-yl)pyridine	8-11	AKT serine/threonine kinase 1	Rattus norvegicus	273-276
19517063-6	2010	RESULTS: Chemopreventive potential of tea polyphenols, was recorded as evident by, low incidence of alveologenic tumors in lungs of animals at tested doses (0.1% and 0.2% of both GTP and BTP) when compared with DEN (20 mg/kg b wt) treated animals.	2,6-bis(1,2,3-triazol-4-yl)pyridine	187-190	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	38-41
19517063-8	2010	GTP and BTP treatment inhibited the expression of Akt, cyclooxygenase-2 and inactivated nuclear factor-kappa B via blocking phosphorylation and subsequent degradation of IkappaB alpha.	2,6-bis(1,2,3-triazol-4-yl)pyridine	8-11	thymoma viral proto-oncogene 1	Mus musculus	50-53
19517063-8	2010	GTP and BTP treatment inhibited the expression of Akt, cyclooxygenase-2 and inactivated nuclear factor-kappa B via blocking phosphorylation and subsequent degradation of IkappaB alpha.	2,6-bis(1,2,3-triazol-4-yl)pyridine	8-11	prostaglandin-endoperoxide synthase 2	Mus musculus	55-110
19517063-8	2010	GTP and BTP treatment inhibited the expression of Akt, cyclooxygenase-2 and inactivated nuclear factor-kappa B via blocking phosphorylation and subsequent degradation of IkappaB alpha.	2,6-bis(1,2,3-triazol-4-yl)pyridine	8-11	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	170-183
19948240-4	2010	Using an affinity purification scheme to identify potential targets of BTP, we identified the actin reorganizing protein, drebrin, and demonstrated that loss of drebrin protein expression prevents store-operated channel mediated Ca(2+) entry, similar to BTP treatment.	2,6-bis(1,2,3-triazol-4-yl)pyridine	71-74	drebrin 1	Homo sapiens	161-168
17948330-5	2007	Upon protonation or metal coordination, the BTP scaffold switches to the chelating syn-syn conformation.	2,6-bis(1,2,3-triazol-4-yl)pyridine	44-47	synemin	Homo sapiens	83-86
19057850-6	2009	In addition, levels of the positive biomarkers: gamma-glutamyl transpeptidase and glutathione-S-transferase (placental form) were reduced with GTP and BTP supplementation.	2,6-bis(1,2,3-triazol-4-yl)pyridine	151-154	hematopoietic prostaglandin D synthase	Rattus norvegicus	82-107
19057850-7	2009	Levels of the negative biomarkers adenosine triphosphatase and glucose-6-phosphatase were also restored by GTP and BTP administration.	2,6-bis(1,2,3-triazol-4-yl)pyridine	115-118	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	63-84
19722586-3	2009	BTP dose-dependently inhibited the activity of pancreatic lipase in vitro with an IC50 of 0.254 mg/mL.	2,6-bis(1,2,3-triazol-4-yl)pyridine	0-3	pancreatic lipase	Rattus norvegicus	47-64
19722586-4	2009	When purified theaflavins, which are components of BTP, were used, theaflavins with galloyl moieties, but not those without galloyl moiety, inhibited the activity of pancreatic lipase.	2,6-bis(1,2,3-triazol-4-yl)pyridine	51-54	pancreatic lipase	Rattus norvegicus	166-183
19722586-6	2009	BTP and TFDG had a similar effect in inhibiting the activity of pancreatic lipase when the total polyphenol amount was adjusted to the same.	2,6-bis(1,2,3-triazol-4-yl)pyridine	0-3	pancreatic lipase	Rattus norvegicus	64-81
19322772-1	2009	Dynamic surfaces: The conformational transition of 2,6-bis(1-aryl-1,2,3-triazol-4-yl)pyridine (BTP) derivatives, triggered by a change in pH, has been observed with a sub-nm resolution by STM at the solid-liquid interface.	2,6-bis(1,2,3-triazol-4-yl)pyridine	95-98	sulfotransferase family 1A member 3	Homo sapiens	188-191
17948330-5	2007	Upon protonation or metal coordination, the BTP scaffold switches to the chelating syn-syn conformation.	2,6-bis(1,2,3-triazol-4-yl)pyridine	44-47	synemin	Homo sapiens	87-90
11592964-6	2001	In a search for safer immunosuppressive drugs, we identified a series of 3,5-bistrifluoromethyl pyrazole (BTP) derivatives that block Th1 and Th2 cytokine gene transcription.	2,6-bis(1,2,3-triazol-4-yl)pyridine	106-109	negative elongation factor complex member C/D	Homo sapiens	134-137
11756245-5	2002	Pre-treatment of PrEC and Du145 cells with doses as low as 20 microg/ml of a mixture of black tea polyphenols (BTP) substantially reduced IGF-I-mediated Akt phosphorylation.	2,6-bis(1,2,3-triazol-4-yl)pyridine	111-114	insulin like growth factor 1	Homo sapiens	138-143
11756245-5	2002	Pre-treatment of PrEC and Du145 cells with doses as low as 20 microg/ml of a mixture of black tea polyphenols (BTP) substantially reduced IGF-I-mediated Akt phosphorylation.	2,6-bis(1,2,3-triazol-4-yl)pyridine	111-114	AKT serine/threonine kinase 1	Homo sapiens	153-156
11756245-6	2002	This effect of BTP appears to be due partially to the reduced autophosphorylation of IGF-I receptor-1 in BTP-treated cells.	2,6-bis(1,2,3-triazol-4-yl)pyridine	15-18	insulin like growth factor 1	Homo sapiens	85-90
11756245-6	2002	This effect of BTP appears to be due partially to the reduced autophosphorylation of IGF-I receptor-1 in BTP-treated cells.	2,6-bis(1,2,3-triazol-4-yl)pyridine	105-108	insulin like growth factor 1	Homo sapiens	85-90
11756245-8	2002	Our results indicate that polyphenols from black tea inhibit the IGF-I signal transduction pathway, which has been linked to increased prostate cancer incidence in human populations and, therefore, provide further support for the potential of BTP to prevent prostate cancer.	2,6-bis(1,2,3-triazol-4-yl)pyridine	243-246	insulin like growth factor 1	Homo sapiens	65-70
34612280-4	2021	On the other hand, bromothiophenol (BTP) fragments significantly upon the electron attachment, producing Br- and (BTP-H)- anions.	2,6-bis(1,2,3-triazol-4-yl)pyridine	36-39	chromosome 12 open reading frame 73	Homo sapiens	105-107
9561168-3	1997	Slight evidence of a synthesis in patients with MS and slightly increased CSF values in stroke patients may suggest that BTP is involved in repair mechanism of damaged brain tissue, or may be related from destroyed brain tissue.	2,6-bis(1,2,3-triazol-4-yl)pyridine	121-124	colony stimulating factor 2	Homo sapiens	74-77
7982762-4	1994	Synthetic bTP was found to induce the expression of Thy 1.2 antigen on T-lymphocytes from athymic mice, in agreement with previous studies on the biological activity of endogenous bTP.	2,6-bis(1,2,3-triazol-4-yl)pyridine	10-13	thymus cell antigen 1, theta	Mus musculus	52-59
7982762-4	1994	Synthetic bTP was found to induce the expression of Thy 1.2 antigen on T-lymphocytes from athymic mice, in agreement with previous studies on the biological activity of endogenous bTP.	2,6-bis(1,2,3-triazol-4-yl)pyridine	180-183	thymus cell antigen 1, theta	Mus musculus	52-59
15022640-5	2004	The GPCR-classification ability of the BTP method had quite high accuracies for classifying GPCR functions at the class level (Classes A, B, C, Frizzled/Smoothened, Non-GPCR, based on the GPCRDB classification scheme), with many classes being classified with 100% accuracy.	2,6-bis(1,2,3-triazol-4-yl)pyridine	39-42	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	4-8
15022640-5	2004	The GPCR-classification ability of the BTP method had quite high accuracies for classifying GPCR functions at the class level (Classes A, B, C, Frizzled/Smoothened, Non-GPCR, based on the GPCRDB classification scheme), with many classes being classified with 100% accuracy.	2,6-bis(1,2,3-triazol-4-yl)pyridine	39-42	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	92-96
15022640-5	2004	The GPCR-classification ability of the BTP method had quite high accuracies for classifying GPCR functions at the class level (Classes A, B, C, Frizzled/Smoothened, Non-GPCR, based on the GPCRDB classification scheme), with many classes being classified with 100% accuracy.	2,6-bis(1,2,3-triazol-4-yl)pyridine	39-42	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	92-96
34328001-3	2021	Herein, inspired by a recent unveiled structure of Zn6(H2O)3(BTP)4 and by means of an amide-functionalized preliminary single tricarboxylate, a subsequent mixed tricarboxylate, and dicarboxylate linkers, an intricate three-way rod MOF and the next three isoreticular three-way rod MOFs have been successfully realized, namely, 3W-ROD-1 and 3W-ROD-2-X (X = -OH, -F, and -CH3), respectively.	2,6-bis(1,2,3-triazol-4-yl)pyridine	61-64	polypyrimidine tract binding protein 3	Homo sapiens	330-342