PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 26045713-0 2015 Chlorogenic acid/chromium supplement rescues diet-induced insulin resistance and obesity in mice. Chlorogenic acid 0-16 insulin Homo sapiens 58-65 26045713-3 2015 The current study investigates whether a Chlorogenic acid/Chromium III supplement rescues obesity and insulin resistance caused by high-fat feeding of male C57BL/6 J mice for 7 weeks. Chlorogenic acid 41-57 insulin Homo sapiens 102-109 26045713-6 2015 These findings underscore the important role that chlorogenic acid and chromium play in maintaining glucose metabolism and insulin response in mice fed a high-fat diet. Chlorogenic acid 50-66 insulin Homo sapiens 123-130 25666384-0 2015 Chlorogenic acid inhibits hypoxia-induced pulmonary artery smooth muscle cells proliferation via c-Src and Shc/Grb2/ERK2 signaling pathway. Chlorogenic acid 0-16 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 97-102 25849026-0 2015 Chlorogenic acid improves late diabetes through adiponectin receptor signaling pathways in db/db mice. Chlorogenic acid 0-16 adiponectin, C1Q and collagen domain containing Mus musculus 48-59 25561311-0 2015 Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1alpha/AKT pathway. Chlorogenic acid 0-16 hypoxia inducible factor 1 subunit alpha Homo sapiens 82-92 25561311-0 2015 Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1alpha/AKT pathway. Chlorogenic acid 0-16 AKT serine/threonine kinase 1 Homo sapiens 93-96 26121855-1 2015 OBJECTIVE: To investigate the effects of chlorogenic acid (CGA) on hepatic stellate cell proliferation and the expression and secretion of Collagen I, Collagen III, tissue inhibitors of metalloproteinase-1 (TIMP-1) and matrix metalloproteinase-2 (MMP-2). Chlorogenic acid 41-57 chromogranin A Rattus norvegicus 59-62 25816913-4 2015 EGCG and chlorogenic acid were found to be more potent inhibitors for selectively inhibiting the two subunits with highest activity, Ct-MGAM and Ct-SI. Chlorogenic acid 9-25 maltase-glucoamylase Homo sapiens 136-140 25816913-6 2015 Inhibition of fast-digesting Ct-MGAM and Ct-SI by EGCG and chlorogenic acid could lead to a slow, but complete, digestion of starch for improved glycemic response of starchy foods with potential health benefit. Chlorogenic acid 59-75 maltase-glucoamylase Homo sapiens 32-36 25466060-1 2015 In this study the impact of covalent complexes of alpha-lactalbumin (alpha-La) with (-)-epigallocatechin gallate (EGCG) or chlorogenic acid (CA) was investigated on the physicochemical properties of beta-carotene oil-in-water emulsions. Chlorogenic acid 123-139 lactalbumin alpha Homo sapiens 50-67 25466060-1 2015 In this study the impact of covalent complexes of alpha-lactalbumin (alpha-La) with (-)-epigallocatechin gallate (EGCG) or chlorogenic acid (CA) was investigated on the physicochemical properties of beta-carotene oil-in-water emulsions. Chlorogenic acid 123-139 lactalbumin alpha Homo sapiens 69-77 25744394-0 2015 Involvement of TLR2 and TLR9 in the anti-inflammatory effects of chlorogenic acid in HSV-1-infected microglia. Chlorogenic acid 65-81 toll like receptor 2 Homo sapiens 15-19 25744394-0 2015 Involvement of TLR2 and TLR9 in the anti-inflammatory effects of chlorogenic acid in HSV-1-infected microglia. Chlorogenic acid 65-81 toll like receptor 9 Homo sapiens 24-28 25666384-0 2015 Chlorogenic acid inhibits hypoxia-induced pulmonary artery smooth muscle cells proliferation via c-Src and Shc/Grb2/ERK2 signaling pathway. Chlorogenic acid 0-16 growth factor receptor bound protein 2 Rattus norvegicus 111-115 25666384-0 2015 Chlorogenic acid inhibits hypoxia-induced pulmonary artery smooth muscle cells proliferation via c-Src and Shc/Grb2/ERK2 signaling pathway. Chlorogenic acid 0-16 mitogen activated protein kinase 1 Rattus norvegicus 116-120 25674248-0 2014 Chlorogenic acid suppresses interleukin-1beta-induced inflammatory mediators in human chondrocytes. Chlorogenic acid 0-16 interleukin 1 beta Homo sapiens 28-45 24825096-9 2015 CONCLUSIONS: The esterification of caffeic acid with quinic acid, producing chlorogenic acid, reduces their ability to inhibit alpha-amylase and alpha-glucosidase activities. Chlorogenic acid 76-92 sucrase-isomaltase Homo sapiens 145-162 25172696-0 2015 Anti-inflammatory effect of chlorogenic acid on the IL-8 production in Caco-2 cells and the dextran sulphate sodium-induced colitis symptoms in C57BL/6 mice. Chlorogenic acid 28-44 C-X-C motif chemokine ligand 8 Homo sapiens 52-56 25172696-2 2015 Effects of CHA and CHA metabolites were evaluated on the IL-8 production in human intestinal Caco-2 cells induced by combined stimulation with tumour necrosis factor alpha (TNFalpha) and H2O2. Chlorogenic acid 11-14 C-X-C motif chemokine ligand 8 Homo sapiens 57-61 25172696-2 2015 Effects of CHA and CHA metabolites were evaluated on the IL-8 production in human intestinal Caco-2 cells induced by combined stimulation with tumour necrosis factor alpha (TNFalpha) and H2O2. Chlorogenic acid 19-22 C-X-C motif chemokine ligand 8 Homo sapiens 57-61 25172696-3 2015 CHA and caffeic acid (CA) inhibited TNFalpha- and H2O2-induced IL-8 production. Chlorogenic acid 0-3 tumor necrosis factor Homo sapiens 36-44 25172696-3 2015 CHA and caffeic acid (CA) inhibited TNFalpha- and H2O2-induced IL-8 production. Chlorogenic acid 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 63-67 25172696-6 2015 Furthermore, increases in the mRNA expression of colonic macrophage inflammatory protein 2 and IL-1beta, which were induced by DSS, were significantly suppressed by CHA supplementation. Chlorogenic acid 165-168 interleukin 1 beta Homo sapiens 95-103 25172711-1 2015 The aim of the study was to characterise the interactions of hydroxycinnamic and chlorogenic acids (CHAs) from green coffee, with isolates of proteins from egg white (EWP), whey (WPC) and soy (SPI), depending on pH and temperature. Chlorogenic acid 100-104 chromogranin A Homo sapiens 193-196 25172711-3 2015 As a result of binding, the concentration of CHAs in proteins ranged from 9.44-12.2, 11.8-13.1 and 12.1-14.4g/100g for SPI, WPC and EWP, respectively. Chlorogenic acid 45-49 chromogranin A Homo sapiens 119-122 25548221-0 2015 IRAK4 as a molecular target in the amelioration of innate immunity-related endotoxic shock and acute liver injury by chlorogenic acid. Chlorogenic acid 117-133 interleukin-1 receptor-associated kinase 4 Mus musculus 0-5 26471424-0 2015 Chlorogenic acid and luteolin synergistically inhibit the proliferation of interleukin-1beta-induced fibroblast-like synoviocytes through regulating the activation of NF-kappaB and JAK/STAT-signaling pathways. Chlorogenic acid 0-16 interleukin 1 beta Homo sapiens 75-92 24825096-3 2015 Thus, this study sought to investigate and compare the interaction of caffeic acid and chlorogenic acid with alpha-amylase and alpha-glucosidase (key enzymes linked to type 2 diabetes) activities in vitro. Chlorogenic acid 87-103 sucrase-isomaltase Homo sapiens 127-144 25874155-0 2015 Corrigendum to "Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3beta and APC and Inhibiting Gene beta-Catenin". Chlorogenic acid 49-65 glycogen synthase kinase 3 beta Homo sapiens 85-94 25874155-0 2015 Corrigendum to "Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3beta and APC and Inhibiting Gene beta-Catenin". Chlorogenic acid 49-65 catenin beta 1 Homo sapiens 123-135 25674248-1 2014 We investigated the anti-inflammatory properties of chlorogenic acid (CGA) in interleukin-1beta-induced chondrocytes. Chlorogenic acid 52-68 interleukin 1 beta Homo sapiens 78-95 25674248-1 2014 We investigated the anti-inflammatory properties of chlorogenic acid (CGA) in interleukin-1beta-induced chondrocytes. Chlorogenic acid 70-73 interleukin 1 beta Homo sapiens 78-95 25394592-1 2014 Chlorogenic acid (5-caffeoylquinic acid, CGA) is a phenolic compound that is found ubiquitously in plants, fruits and vegetables and is formed via the esterification of caffeic acid and quinic acid. Chlorogenic acid 0-16 chromogranin A Rattus norvegicus 41-44 25532332-7 2014 Based on the above reviewed method, taking a NIR spectral assignment of chlorogenic acid as example, a reliable spectral assignment for critical quality attributes of Chinese materia medica (CMM) was established using deuterium technology and spectral variable selection. Chlorogenic acid 72-88 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 45-48 25187964-0 2014 Chlorogenic acid protects against atherosclerosis in ApoE-/- mice and promotes cholesterol efflux from RAW264.7 macrophages. Chlorogenic acid 0-16 apolipoprotein E Mus musculus 53-57 24887396-5 2014 The levels of IFN-gamma and TNF-alpha were lower (P<0.05) in the jejunal and colon of weaned rats receiving CHA supplementation, in comparison with the control group. Chlorogenic acid 111-114 interferon gamma Rattus norvegicus 14-23 25153629-0 2014 Enhancement of chlorogenic acid production in hairy roots of Platycodon grandiflorum by over-expression of an Arabidopsis thaliana transcription factor AtPAP1. Chlorogenic acid 15-31 phosphatidic acid phosphatase 1 Arabidopsis thaliana 152-158 25153629-1 2014 To improve the production of chlorogenic acid (CGA) in hairy roots of Platycodon grandiflorum, we induced over-expression of Arabidopsis thaliana transcription factor production of anthocyanin pigment (AtPAP1) using an Agrobacterium rhizogenes-mediated transformation system. Chlorogenic acid 29-45 phosphatidic acid phosphatase 1 Arabidopsis thaliana 202-208 24941343-6 2014 The result showed both FLJ and chlorogenic acid had inhibitory activities against the expression of 53-kDa HDC and histamine production. Chlorogenic acid 31-47 histidine decarboxylase Homo sapiens 107-110 24887396-8 2014 Immunohistochemical analysis of tight junction proteins revealed that ZO-1 and occludin protein abundances in the jejunum and colon were increased (P<0.05) by CHA supplementation. Chlorogenic acid 162-165 occludin Rattus norvegicus 79-87 24887396-5 2014 The levels of IFN-gamma and TNF-alpha were lower (P<0.05) in the jejunal and colon of weaned rats receiving CHA supplementation, in comparison with the control group. Chlorogenic acid 111-114 tumor necrosis factor Rattus norvegicus 28-37 24887396-7 2014 CHA supplementation decreased (P<0.05) intestinal permeability, which was indicated by the ratio of lactulose to mannitol and serum DAO activity, when compared to weaned rats with LPS challenge. Chlorogenic acid 0-3 D-amino-acid oxidase Rattus norvegicus 135-138 24887396-8 2014 Immunohistochemical analysis of tight junction proteins revealed that ZO-1 and occludin protein abundances in the jejunum and colon were increased (P<0.05) by CHA supplementation. Chlorogenic acid 162-165 tight junction protein 1 Rattus norvegicus 70-74 24457123-0 2014 Chlorogenic acid attenuates lipopolysaccharide-induced mice mastitis by suppressing TLR4-mediated NF-kappaB signaling pathway. Chlorogenic acid 0-16 toll-like receptor 4 Mus musculus 84-88 24583048-3 2014 This study found that with the pre-treatment of chlorogenic acid in Iso-induced neonatal rat myocytes, the levels of the hypertrophic markers, ANP, BNP and beta-MHC decreased. Chlorogenic acid 48-64 natriuretic peptide B Rattus norvegicus 148-151 24816176-0 2014 Tetrachlorobenzoquinone induces acute liver injury, up-regulates HO-1 and NQO1 expression in mice model: the protective role of chlorogenic acid. Chlorogenic acid 128-144 NAD(P)H dehydrogenase, quinone 1 Mus musculus 74-78 24598787-5 2014 At these concentrations chlorogenic acid significantly decreased platelet inflammatory mediators (sP-selectin, sCD40L, CCL5 and IL-1beta) and increased intraplatelet cAMP levels/PKA activation. Chlorogenic acid 24-40 C-C motif chemokine ligand 5 Homo sapiens 119-123 24598787-5 2014 At these concentrations chlorogenic acid significantly decreased platelet inflammatory mediators (sP-selectin, sCD40L, CCL5 and IL-1beta) and increased intraplatelet cAMP levels/PKA activation. Chlorogenic acid 24-40 interleukin 1 beta Homo sapiens 128-136 24598787-7 2014 Chlorogenic acid is compatible to the active site of the adenosine A2A receptor as revealed through molecular modeling. Chlorogenic acid 0-16 adenosine A2a receptor Homo sapiens 57-79 25174114-7 2014 CONCLUSION: Chlorogenic acid can protect NPCs against apoptosis by oxidative stress through decreasing reactive oxygen species production and increasing anti-apoptotic protein BCL-2 expression in NPCs by activation of PI3K-Akt signaling pathways. Chlorogenic acid 12-28 BCL2, apoptosis regulator Rattus norvegicus 176-181 25174114-7 2014 CONCLUSION: Chlorogenic acid can protect NPCs against apoptosis by oxidative stress through decreasing reactive oxygen species production and increasing anti-apoptotic protein BCL-2 expression in NPCs by activation of PI3K-Akt signaling pathways. Chlorogenic acid 12-28 AKT serine/threonine kinase 1 Rattus norvegicus 223-226 24257718-1 2014 BACKGROUND: Epidemiologic and experimental data have suggested that chlorogenic acid, which is a polyphenol contained in green coffee beans, prevents diet-induced hepatic steatosis and insulin resistance. Chlorogenic acid 68-84 insulin Homo sapiens 185-192 23411245-1 2013 The kinetics of degradation of chlorogenic acid (CG), (-) epicatechin (EPI), L-ascorbic acid (AA) and polyphenoloxidase (PPO) activity from Marie-Menard apple in pH 3.8 solutions at 20 and 50 C were investigated to provide information on the impact of the presence of CG, EPI and/or AA on PPO thermostability. Chlorogenic acid 268-270 polyphenol oxidase, chloroplastic Malus domestica 121-124 24583782-5 2014 Incorporation efficiencies into skin of chlorogenic acid and resveratrol induced by MESL at 40 h after application were about 6-fold and 19-fold higher in the epidermis and 3.5-fold and 15-fold higher in the dermis, respectively, than those by MEK. Chlorogenic acid 40-56 mitogen-activated protein kinase kinase 7 Homo sapiens 244-247 24431915-4 2014 The amplitude of ring 5 was significantly higher on multifocal electroretinography after 3 months of chlorogenic acid supplementation (7.2 +- 9.5 vs 8.3 +- 10.8 nV/deg(2), mean +- standard deviation, P = 0.022). Chlorogenic acid 101-117 ring finger protein 5 Homo sapiens 17-23 24380573-3 2014 Pretreatment with tannic or chlorogenic acid resulted in a significant decrease in the phosphorylation of EGFR Y-1068 and Y-1173 tyrosine residues, which was accompanied by reduced activation of AP-1. Chlorogenic acid 28-44 epidermal growth factor receptor Mus musculus 106-110 24380573-3 2014 Pretreatment with tannic or chlorogenic acid resulted in a significant decrease in the phosphorylation of EGFR Y-1068 and Y-1173 tyrosine residues, which was accompanied by reduced activation of AP-1. Chlorogenic acid 28-44 jun proto-oncogene Mus musculus 195-199 24127072-7 2014 RESULTS: Chlorogenic acid significantly inhibited not only NO production but also the expression of COX-2 and iNOS, without any cytotoxicity. Chlorogenic acid 9-25 prostaglandin-endoperoxide synthase 2 Mus musculus 100-105 24127072-7 2014 RESULTS: Chlorogenic acid significantly inhibited not only NO production but also the expression of COX-2 and iNOS, without any cytotoxicity. Chlorogenic acid 9-25 nitric oxide synthase 2, inducible Mus musculus 110-114 24127072-8 2014 Chlorogenic acid also attenuated pro-inflammatory cytokines (including IL-1beta and TNF-alpha) and other inflammation-related markers such as IL-6 in a dose-dependent manner. Chlorogenic acid 0-16 interleukin 1 beta Mus musculus 71-79 24127072-8 2014 Chlorogenic acid also attenuated pro-inflammatory cytokines (including IL-1beta and TNF-alpha) and other inflammation-related markers such as IL-6 in a dose-dependent manner. Chlorogenic acid 0-16 tumor necrosis factor Mus musculus 84-93 24127072-8 2014 Chlorogenic acid also attenuated pro-inflammatory cytokines (including IL-1beta and TNF-alpha) and other inflammation-related markers such as IL-6 in a dose-dependent manner. Chlorogenic acid 0-16 interleukin 6 Mus musculus 142-146 24127072-9 2014 Additionally, endotoxin-induced adhesion of macrophages and the expression level of ninjurin1 (Ninj1) were decreased by chlorogenic acid. Chlorogenic acid 120-136 ninjurin 1 Mus musculus 84-93 24127072-9 2014 Additionally, endotoxin-induced adhesion of macrophages and the expression level of ninjurin1 (Ninj1) were decreased by chlorogenic acid. Chlorogenic acid 120-136 ninjurin 1 Mus musculus 95-100 24127072-10 2014 Finally, chlorogenic acid inhibited the nuclear translocation of NF-kappaB. Chlorogenic acid 9-25 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 65-74 24064570-8 2013 The secretion rate of beta-hexosaminidase by RBL-2H3 cells clearly increased following treatment with chlorogenic acid and the levels of cytoskeletal disintegration were also markedly increased. Chlorogenic acid 102-118 O-GlcNAcase Rattus norvegicus 22-41 24064570-8 2013 The secretion rate of beta-hexosaminidase by RBL-2H3 cells clearly increased following treatment with chlorogenic acid and the levels of cytoskeletal disintegration were also markedly increased. Chlorogenic acid 102-118 RB transcriptional corepressor like 2 Rattus norvegicus 45-50 24064570-11 2013 In conclusion, chlorogenic acid may lead to the aggregation of lipid rafts on the cell membrane surface by altering RBL-2H3 cell membrane fluidity, thus triggering Syk-related signal transduction and inducing a truncated type I like allergic reaction. Chlorogenic acid 15-31 spleen associated tyrosine kinase Rattus norvegicus 164-167 24761676-0 2013 [Effects of chlorogenic acid on the viability and HIF-1alpha mRNA expression of PC12 cells exposed to hypoxia]. Chlorogenic acid 12-28 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 50-60 24761676-1 2013 OBJECTIVE: To investigate the effects of chlorogenic acid on the viability and HIF-1alpha mRNA expression of PC12 cells exposed to hypoxia. Chlorogenic acid 41-57 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 79-89 24761676-4 2013 RESULTS: Chlorogenic acid significantly improved the viability of cells exposed to hypoxia, decreased LDH release, arrested the cell cycle on G1 phase, and increased the gene expression level of HIF-1alpha. Chlorogenic acid 9-25 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 195-205 24761676-5 2013 CONCLUSION: Chlorogenic acid protects PC12 cells from hypoxic damage by improving the expression of HIF-1alpha. Chlorogenic acid 12-28 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 100-110 23411245-4 2013 Apple PPO was thermolabile, denaturing after 10min at 70 C. Losses of PPO activity were favoured by the presence of EPI in model solutions, compared with CG, due to the formation of o-quinones of EPI (QEPI) lowering PPO stability. Chlorogenic acid 154-156 polyphenol oxidase, chloroplastic Malus domestica 6-9 23692950-3 2013 The complete hydrolysis of 5-caffeoylquinic acid (5-CQA) into caffeic acid (CA) by L. johnsonii esterase occurred during the first 16 h of reaction time. Chlorogenic acid 50-55 SGNH/GDSL hydrolase family protein Lactobacillus johnsonii NCC 533 96-104 23021851-8 2013 Furthermore, the inhibition investigation demonstrates that fisetin and chlorogenic acid can inhibit the M. SssI MTase activity with the IC(50) value of 153.12 and 137.07 muM, respectively. Chlorogenic acid 72-88 latexin Homo sapiens 171-174 22674675-0 2013 Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-alpha in hypercholesterolemic rats induced with a high-cholesterol diet. Chlorogenic acid 0-16 peroxisome proliferator activated receptor alpha Rattus norvegicus 126-136 22976935-8 2013 Downstream inflammasome proteins like IL-1beta and caspase 1 increased within the prostate and decreased with CHA treatment. Chlorogenic acid 110-113 interleukin 1 beta Rattus norvegicus 38-46 23303212-6 2013 Electron-storage function was conferred by the redox-active food phenolic chlorogenic acid (CA) that was enzymatically grafted to the chitosan scaffold using tyrosinase. Chlorogenic acid 74-90 tyrosinase Homo sapiens 158-168 22976935-8 2013 Downstream inflammasome proteins like IL-1beta and caspase 1 increased within the prostate and decreased with CHA treatment. Chlorogenic acid 110-113 caspase 1 Rattus norvegicus 51-60 23168580-0 2013 Chlorogenic acid attenuates high mobility group box 1 (HMGB1) and enhances host defense mechanisms in murine sepsis. Chlorogenic acid 0-16 high mobility group box 1 Mus musculus 28-53 23184188-2 2013 The result revealed that caffeic acid and chlorogenic acid inhibited AChE and BChE activities in dose-dependent manner; however, caffeic acid had a higher inhibitory effect on AChE and BChE activities than chlorogenic acid. Chlorogenic acid 42-58 acetylcholinesterase Rattus norvegicus 69-73 23184188-2 2013 The result revealed that caffeic acid and chlorogenic acid inhibited AChE and BChE activities in dose-dependent manner; however, caffeic acid had a higher inhibitory effect on AChE and BChE activities than chlorogenic acid. Chlorogenic acid 42-58 butyrylcholinesterase Rattus norvegicus 78-82 23184188-2 2013 The result revealed that caffeic acid and chlorogenic acid inhibited AChE and BChE activities in dose-dependent manner; however, caffeic acid had a higher inhibitory effect on AChE and BChE activities than chlorogenic acid. Chlorogenic acid 42-58 acetylcholinesterase Rattus norvegicus 176-180 23184188-2 2013 The result revealed that caffeic acid and chlorogenic acid inhibited AChE and BChE activities in dose-dependent manner; however, caffeic acid had a higher inhibitory effect on AChE and BChE activities than chlorogenic acid. Chlorogenic acid 42-58 butyrylcholinesterase Rattus norvegicus 185-189 23184188-2 2013 The result revealed that caffeic acid and chlorogenic acid inhibited AChE and BChE activities in dose-dependent manner; however, caffeic acid had a higher inhibitory effect on AChE and BChE activities than chlorogenic acid. Chlorogenic acid 206-222 acetylcholinesterase Rattus norvegicus 69-73 23184188-2 2013 The result revealed that caffeic acid and chlorogenic acid inhibited AChE and BChE activities in dose-dependent manner; however, caffeic acid had a higher inhibitory effect on AChE and BChE activities than chlorogenic acid. Chlorogenic acid 206-222 butyrylcholinesterase Rattus norvegicus 78-82 23168580-0 2013 Chlorogenic acid attenuates high mobility group box 1 (HMGB1) and enhances host defense mechanisms in murine sepsis. Chlorogenic acid 0-16 high mobility group box 1 Mus musculus 55-60 23168580-2 2013 In the current study in murine peritoneal macrophages, chlorogenic acid suppressed endotoxin-induced high mobility group box 1 (HMGB1) release in a concentration-dependent manner. Chlorogenic acid 55-71 high mobility group box 1 Mus musculus 101-126 23168580-2 2013 In the current study in murine peritoneal macrophages, chlorogenic acid suppressed endotoxin-induced high mobility group box 1 (HMGB1) release in a concentration-dependent manner. Chlorogenic acid 55-71 high mobility group box 1 Mus musculus 128-133 23168580-3 2013 Administration of chlorogenic acid also attenuated systemic HMGB1 accumulation in vivo and prevented mortality induced by endotoxemia and polymicrobial sepsis. Chlorogenic acid 18-34 high mobility group box 1 Mus musculus 60-65 23168580-4 2013 The mechanisms of action of chlorogenic acid included attenuation of the increase in toll-like receptor (TLR)-4 expression and suppression of sepsis-induced signaling pathways, such as c-Jun NH2-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB, which are critical for cytokine release. Chlorogenic acid 28-44 toll-like receptor 4 Mus musculus 85-111 23168580-4 2013 The mechanisms of action of chlorogenic acid included attenuation of the increase in toll-like receptor (TLR)-4 expression and suppression of sepsis-induced signaling pathways, such as c-Jun NH2-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB, which are critical for cytokine release. Chlorogenic acid 28-44 mitogen-activated protein kinase 8 Mus musculus 185-210 23168580-4 2013 The mechanisms of action of chlorogenic acid included attenuation of the increase in toll-like receptor (TLR)-4 expression and suppression of sepsis-induced signaling pathways, such as c-Jun NH2-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB, which are critical for cytokine release. Chlorogenic acid 28-44 mitogen-activated protein kinase 8 Mus musculus 212-215 23168580-4 2013 The mechanisms of action of chlorogenic acid included attenuation of the increase in toll-like receptor (TLR)-4 expression and suppression of sepsis-induced signaling pathways, such as c-Jun NH2-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB, which are critical for cytokine release. Chlorogenic acid 28-44 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 266-292 23219790-0 2013 Contribution of serum IL-4 and IgE to the early prediction of allergic reactions induced by chlorogenic acid. Chlorogenic acid 92-108 interleukin-4 Cavia porcellus 22-26 23146752-0 2013 Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. Chlorogenic acid 0-16 toll-like receptor 4 Rattus norvegicus 79-99 23184188-1 2013 This study sought to investigate and compare the interaction of caffeic acid and chlorogenic acid on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and some pro-oxidants (FeSO(4), sodium nitroprusside and quinolinic acid) induced oxidative stress in rat brain in vitro. Chlorogenic acid 81-97 acetylcholinesterase Rattus norvegicus 101-121 23184188-1 2013 This study sought to investigate and compare the interaction of caffeic acid and chlorogenic acid on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and some pro-oxidants (FeSO(4), sodium nitroprusside and quinolinic acid) induced oxidative stress in rat brain in vitro. Chlorogenic acid 81-97 acetylcholinesterase Rattus norvegicus 123-127 23184188-1 2013 This study sought to investigate and compare the interaction of caffeic acid and chlorogenic acid on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and some pro-oxidants (FeSO(4), sodium nitroprusside and quinolinic acid) induced oxidative stress in rat brain in vitro. Chlorogenic acid 81-97 butyrylcholinesterase Rattus norvegicus 133-154 23184188-1 2013 This study sought to investigate and compare the interaction of caffeic acid and chlorogenic acid on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and some pro-oxidants (FeSO(4), sodium nitroprusside and quinolinic acid) induced oxidative stress in rat brain in vitro. Chlorogenic acid 81-97 butyrylcholinesterase Rattus norvegicus 156-160 23336518-3 2013 The results showed that chlorogenic acid, 3, 4-dicaffeoylquinic acid, 3, 5-dicaffeoylquinic acid and 4, 5-dicaffeoylquinic acid significantly inhibited the prostaglandin E(2) (PGE(2)) release and reversed the interleukin-6 (IL-6) secretion of macrophages (p < 0.05). Chlorogenic acid 24-40 interleukin 6 Homo sapiens 209-222 23336518-3 2013 The results showed that chlorogenic acid, 3, 4-dicaffeoylquinic acid, 3, 5-dicaffeoylquinic acid and 4, 5-dicaffeoylquinic acid significantly inhibited the prostaglandin E(2) (PGE(2)) release and reversed the interleukin-6 (IL-6) secretion of macrophages (p < 0.05). Chlorogenic acid 24-40 interleukin 6 Homo sapiens 224-228 23844319-0 2013 Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3 beta and APC and Inhibiting Gene beta -Catenin. Chlorogenic acid 33-49 glycogen synthase kinase 3 beta Mus musculus 69-79 23844319-0 2013 Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3 beta and APC and Inhibiting Gene beta -Catenin. Chlorogenic acid 33-49 catenin (cadherin associated protein), beta 1 Mus musculus 108-121 23844319-2 2013 Inhibiting gene beta -catenin and inducting genes GSK-3 beta and APC, promoting the tumor cell apoptosis in Wnt pathway, by chlorogenic acid were discussed (CGA). Chlorogenic acid 124-140 catenin (cadherin associated protein), beta 1 Mus musculus 16-29 23844319-2 2013 Inhibiting gene beta -catenin and inducting genes GSK-3 beta and APC, promoting the tumor cell apoptosis in Wnt pathway, by chlorogenic acid were discussed (CGA). Chlorogenic acid 124-140 glycogen synthase kinase 3 beta Mus musculus 50-60 23844319-2 2013 Inhibiting gene beta -catenin and inducting genes GSK-3 beta and APC, promoting the tumor cell apoptosis in Wnt pathway, by chlorogenic acid were discussed (CGA). Chlorogenic acid 124-140 chromogranin A Mus musculus 157-160 23160680-7 2012 Furthermore, the activity of caspase-3 was evaluated and results indicated that chlorogenic acid promoted caspase-3 activity in U937 cells. Chlorogenic acid 80-96 caspase 3 Homo sapiens 29-38 23241445-11 2012 The phosphorylation of extracellular signal-regulated kinase, c-Jun N-terminal kinase (JNK), and p38 was significantly reduced by WIN-34B treatment, while phosphorylation of JNK was only inhibited by chlorogenic acid or mangiferin in IL-1beta-stimulated chondrocytes. Chlorogenic acid 200-216 mitogen-activated protein kinase 8 Homo sapiens 174-177 23449492-0 2013 Prevention of topical surfactant-induced itch-related responses by chlorogenic acid through the inhibition of increased histamine production in the epidermis. Chlorogenic acid 67-83 itchy, E3 ubiquitin protein ligase Mus musculus 41-45 23449492-2 2013 Topical application of sodium laurate increased hind-paw scratching, an itch-related response, 2 h after application, which was inhibited by topical post-treatment with chlorogenic acid. Chlorogenic acid 169-185 itchy, E3 ubiquitin protein ligase Mus musculus 72-76 23160680-7 2012 Furthermore, the activity of caspase-3 was evaluated and results indicated that chlorogenic acid promoted caspase-3 activity in U937 cells. Chlorogenic acid 80-96 caspase 3 Homo sapiens 106-115 23160680-8 2012 Results from western blot analysis showed that chlorogenic acid promoted expression of caspase-3, -7, -8 and -9 in U937 cells. Chlorogenic acid 47-63 caspase 3 Homo sapiens 87-111 23160680-9 2012 Taken together, these results suggest that chlorogenic acid may induce apoptosis by reducing the levels of DeltaPsim and by increasing the activation of caspase-3 pathways in human leukemia U937 cells in vitro. Chlorogenic acid 43-59 caspase 3 Homo sapiens 153-162 22227267-2 2012 We explored whether chlorogenic acid and its metabolite, caffeic acid, act directly on skeletal muscle to stimulate 5"-adenosine monophosphate-activated protein kinase (AMPK). Chlorogenic acid 20-36 protein kinase AMP-activated catalytic subunit alpha 1 Rattus norvegicus 169-173 23073199-0 2012 [Molecular docking of chlorogenic acid, 3,4-di-O-caffeoylquinic acid and 3,5-di-O-caffeoylquinic acid with human serum albumin]. Chlorogenic acid 22-38 albumin Homo sapiens 119-126 22885765-2 2012 Chlorogenic acid dose-dependently inhibited collagen-induced platelet aggregation, and suppressed the production of thromboxane A2 (TXA2), an intracellular Ca-agonist as an aggregation-inducing autacoidal molecule, which was associated with the strong inhibition of cyclooxygenase (COX)-1 in platelet microsomes having cytochrome c reductase activity. Chlorogenic acid 0-16 mitochondrially encoded cytochrome c oxidase I Homo sapiens 266-288 23073199-1 2012 OBJECTIVE: To investigate the mechanism of binding of human serum albumin (HSA) with potential sensitinogen, including chlorogenic acid and two isochlorogenic acids (3,4-di-O-caffeoylquinic acid and 3,5-di-O-caffeoylquinic acid). Chlorogenic acid 119-135 albumin Homo sapiens 60-73 22107990-12 2012 The phytochemical study of Ba-CAE showed the presence of flavones as luteolin and acacetin, caffeoylquinic acids as chlorogenic acid, and tannins. Chlorogenic acid 116-132 gap junction protein alpha 8 Homo sapiens 30-33 22833076-2 2012 Much effort has been expended towards the chemical characterisation of the components of the roasted coffee bean, frequently termed melanoidines, which are dominated byproducts formed from its most relevant secondary metabolites - chlorogenic acids. Chlorogenic acid 231-248 brain expressed associated with NEDD4 1 Homo sapiens 108-112 22349733-1 2012 Phenylalanine ammonia lyase (PAL) is the first entry enzyme of the phenylpropanoid pathway producing phenolics, widespread constituents of plant foods and beverages, including chlorogenic acids, polyphenols found at remarkably high levels in the coffee bean and long recognized as powerful antioxidants. Chlorogenic acid 176-193 phenylalanine ammonia-lyase Solanum lycopersicum 29-32 22962530-0 2012 Cytoprotective effect of chlorogenic acid against alpha-synuclein-related toxicity in catecholaminergic PC12 cells. Chlorogenic acid 25-41 synuclein alpha Rattus norvegicus 50-65 22962530-5 2012 Chlorogenic acid inhibits several DA/alpha-synuclein-related phenomenon, including the oxidation of dopamine, the interaction of oxidized dopamine with alpha-synuclein, and the oligomerization of alpha-synuclein under dopamine existing conditions in vitro. Chlorogenic acid 0-16 synuclein alpha Rattus norvegicus 37-52 22962530-5 2012 Chlorogenic acid inhibits several DA/alpha-synuclein-related phenomenon, including the oxidation of dopamine, the interaction of oxidized dopamine with alpha-synuclein, and the oligomerization of alpha-synuclein under dopamine existing conditions in vitro. Chlorogenic acid 0-16 synuclein alpha Rattus norvegicus 152-167 22962530-5 2012 Chlorogenic acid inhibits several DA/alpha-synuclein-related phenomenon, including the oxidation of dopamine, the interaction of oxidized dopamine with alpha-synuclein, and the oligomerization of alpha-synuclein under dopamine existing conditions in vitro. Chlorogenic acid 0-16 synuclein alpha Rattus norvegicus 152-167 22747429-3 2012 The current study investigates the molecular interactions between the allosteric site of PTP1B with two caffeoyl derivatives, chlorogenic acid (CGA) and cichoric acid (CHA), using computational strategies. Chlorogenic acid 126-142 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 89-94 22747429-3 2012 The current study investigates the molecular interactions between the allosteric site of PTP1B with two caffeoyl derivatives, chlorogenic acid (CGA) and cichoric acid (CHA), using computational strategies. Chlorogenic acid 144-147 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 89-94 22659584-0 2012 Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia. Chlorogenic acid 0-16 matrix metallopeptidase 2 Rattus norvegicus 66-98 22434333-2 2012 In this work, the interactions of bovine serum albumin (BSA) with six HCA derivatives, including chlorogenic acid (CHA), caffeic acid (CFA), m-coumaric acid (m-CA), p-coumaric acid (p-CA), ferulic acid (FA) and sinapic acid (SA) have been investigated by NMR spectroscopic techniques in combination with fluorescence and molecular modeling methods. Chlorogenic acid 97-113 albumin Homo sapiens 41-54 22434333-2 2012 In this work, the interactions of bovine serum albumin (BSA) with six HCA derivatives, including chlorogenic acid (CHA), caffeic acid (CFA), m-coumaric acid (m-CA), p-coumaric acid (p-CA), ferulic acid (FA) and sinapic acid (SA) have been investigated by NMR spectroscopic techniques in combination with fluorescence and molecular modeling methods. Chlorogenic acid 115-118 albumin Homo sapiens 41-54 22269060-7 2012 Leucoanthocyanidin reductase (LAR1) co-located with a QTL cluster for the fruit flavanols catechin, epicatechin, procyanidin dimer and five unknown procyanidin oligomers identified near the top of linkage group (LG) 16, while hydroxy cinnamate/quinate transferase (HCT/HQT) co-located with a QTL for chlorogenic acid concentration mapping near the bottom of LG 17. Chlorogenic acid 300-316 leucoanthocyanidin reductase-like Malus domestica 30-34 21749866-3 2012 Here, we showed that Chlorogenic acid suppressed reactive oxygen species increase by activation of Akt phosphorylation,and increased FOXO family genes and anti-apoptotic protein Bcl-2 expression in MSCs culturing under oxidative stress. Chlorogenic acid 21-37 AKT serine/threonine kinase 1 Homo sapiens 99-102 21749866-3 2012 Here, we showed that Chlorogenic acid suppressed reactive oxygen species increase by activation of Akt phosphorylation,and increased FOXO family genes and anti-apoptotic protein Bcl-2 expression in MSCs culturing under oxidative stress. Chlorogenic acid 21-37 BCL2 apoptosis regulator Homo sapiens 178-183 21749866-4 2012 In addition, PI-3Kinase Inhibitor (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, LY294002) could suppress the Chlorogenic acid-induced: (1) the cellular protective role, (2) the increase of the FOXO family genes expression, (3) increased expression of Bcl-2. Chlorogenic acid 114-130 BCL2 apoptosis regulator Homo sapiens 256-261 21749866-5 2012 These results suggested that Chlorogenic acid protected MSCs against apoptosis via PI3K/AKT signal and FOXO family genes. Chlorogenic acid 29-45 AKT serine/threonine kinase 1 Homo sapiens 88-91 21936496-3 2011 Polyphenols identified in the date extract, such as chlorogenic acid, caffeic acid, pelargonin and ferulic acid, stimulated IFN-gamma mRNA expression significantly in mouse Peyer"s patch cell cultures. Chlorogenic acid 52-68 interferon gamma Mus musculus 124-133 22291473-3 2012 One promising nutraceutical is green coffee extract, which contains high concentrations of chlorogenic acids that are known to have health benefits and to influence glucose and fat metabolism. Chlorogenic acid 91-108 FAT atypical cadherin 1 Homo sapiens 177-180 22412912-0 2012 Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes. Chlorogenic acid 0-16 protein kinase, AMP-activated, alpha 1 catalytic subunit Mus musculus 69-73 25212296-0 2011 Apple polyphenoloxidase inactivation during heating in the presence of ascorbic acid and chlorogenic acid. Chlorogenic acid 89-105 polyphenol oxidase, chloroplastic Malus domestica 6-23 25212296-6 2011 Thus, during heating, provided PPO remained active with enough available O2 in the model systems, CG oxidation and coupled oxidoreduction with AA could readily develop. Chlorogenic acid 98-100 polyphenol oxidase, chloroplastic Malus domestica 31-34 21936496-4 2011 Chlorogenic acid and caffeic acid also increased the number of IFN-gamma(+)CD4(+) cells significantly, while some polyphenols increased the number of IFN-gamma(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. Chlorogenic acid 0-16 interferon gamma Homo sapiens 63-72 21936496-4 2011 Chlorogenic acid and caffeic acid also increased the number of IFN-gamma(+)CD4(+) cells significantly, while some polyphenols increased the number of IFN-gamma(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. Chlorogenic acid 0-16 integrin subunit alpha M Homo sapiens 183-188 22291761-4 2011 The aim of this study was to investigate whether SMN2 expression can be increased by caffeic acid, chlorogenic acid and curcumin, which are designed by modifications of the carboxylic acid class of histone deacetylase (HDAC) inhibitors. Chlorogenic acid 99-115 survival of motor neuron 2, centromeric Homo sapiens 49-53 21977912-0 2011 Chlorogenic acid differentially affects postprandial glucose and glucose-dependent insulinotropic polypeptide response in rats. Chlorogenic acid 0-16 gastric inhibitory polypeptide Rattus norvegicus 65-109 21656371-0 2011 Inhibitory effects of chlorogenic acid on aldose reductase activity in vitro and cataractogenesis in galactose-fed rats. Chlorogenic acid 22-38 aldo-keto reductase family 1 member B1 Rattus norvegicus 42-58 21448860-0 2011 Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo. Chlorogenic acid 16-32 NFE2 like bZIP transcription factor 2 Homo sapiens 103-107 22291761-6 2011 We performed LDH cytotoxicity assay to analyse whether SMN2 activating concentrations of caffeic acid, chlorogenic acid and curcumin were cytotoxic to fibroblasts. Chlorogenic acid 103-119 survival of motor neuron 2, centromeric Homo sapiens 55-59 22291761-4 2011 The aim of this study was to investigate whether SMN2 expression can be increased by caffeic acid, chlorogenic acid and curcumin, which are designed by modifications of the carboxylic acid class of histone deacetylase (HDAC) inhibitors. Chlorogenic acid 99-115 histone deacetylase 9 Homo sapiens 198-217 22291761-4 2011 The aim of this study was to investigate whether SMN2 expression can be increased by caffeic acid, chlorogenic acid and curcumin, which are designed by modifications of the carboxylic acid class of histone deacetylase (HDAC) inhibitors. Chlorogenic acid 99-115 histone deacetylase 9 Homo sapiens 219-223 21628897-2 2011 Chlorogenic acid examined the inhibitory effects upon rat lens aldose reductase (AR) activity and xylose-induced rat lens opacity. Chlorogenic acid 0-16 aldo-keto reductase family 1 member B1 Rattus norvegicus 63-79 21207116-9 2011 It is noteworthy to observe that the main compounds present in the ASc, as gallic acid (the major component), chlorogenic acid and rutin, might be the responsible for such benefit, since they were found to display antioxidant properties. Chlorogenic acid 110-126 PYD and CARD domain containing Rattus norvegicus 67-70 21052977-10 2011 Addition of the G6PT inhibitor chlorogenic acid to primary hepatocytes suppressed H6PDH production. Chlorogenic acid 31-47 solute carrier family 37 (glucose-6-phosphate transporter), member 4 Mus musculus 16-20 21628897-2 2011 Chlorogenic acid examined the inhibitory effects upon rat lens aldose reductase (AR) activity and xylose-induced rat lens opacity. Chlorogenic acid 0-16 aldo-keto reductase family 1 member B1 Rattus norvegicus 81-83 21628897-4 2011 Chlorogenic acid showed potential inhibitory activity against rat lens AR, with an IC50 value of 0.95 microM. Chlorogenic acid 0-16 aldo-keto reductase family 1 member B1 Rattus norvegicus 71-73 21597194-1 2011 Chlorogenic acid (CQA) is one of the major polyphenols in apple and a good substrate for the polyphenol oxidase (PPO) in apple. Chlorogenic acid 0-16 polyphenol oxidase, chloroplastic Malus domestica 93-111 22146710-5 2011 The reduced serum levels of C-reactive protein, an inflammatory cytokine, by the chlorogenic acid + rutin fraction and FG fraction might be associated with alleviating the metabolic abnormalities in obese rats. Chlorogenic acid 81-97 C-reactive protein Rattus norvegicus 28-46 21697612-2 2011 In this study, we performed uptake experiments using Xenopus laevis oocytes to assess the inhibitory effects of chlorogenic acid, caffeic acid and quinic acid, which are contained in coffee, fruits and vegetables, on human organic anion transporters hOAT1 and hOAT3; these transporters mediate renal tubular uptake of anionic drugs from blood. Chlorogenic acid 112-128 solute carrier family 22 member 6 Homo sapiens 250-255 21697612-2 2011 In this study, we performed uptake experiments using Xenopus laevis oocytes to assess the inhibitory effects of chlorogenic acid, caffeic acid and quinic acid, which are contained in coffee, fruits and vegetables, on human organic anion transporters hOAT1 and hOAT3; these transporters mediate renal tubular uptake of anionic drugs from blood. Chlorogenic acid 112-128 solute carrier family 22 member 8 Homo sapiens 260-265 20951230-0 2011 Anti-arthritic effects of chlorogenic acid in interleukin-1beta-induced rabbit chondrocytes and a rabbit osteoarthritis model. Chlorogenic acid 26-42 interleukin-1 beta Oryctolagus cuniculus 46-63 21597194-1 2011 Chlorogenic acid (CQA) is one of the major polyphenols in apple and a good substrate for the polyphenol oxidase (PPO) in apple. Chlorogenic acid 0-16 polyphenol oxidase, chloroplastic Malus domestica 113-116 20854262-2 2010 The chlorogenic acid derivative S4048 is a pharmacological inhibitor of the glucose 6-phosphate transporter, which is part of glucose-6-phosphatase, and allows for mechanistic studies concerning metabolic defects in GSD-1. Chlorogenic acid 4-20 glucose-6-phosphatase, catalytic Mus musculus 126-147 20655275-2 2010 In this paper, caffeic acid (CaA), chlorogenic acid (ChA) and ferulic acid (FA) were selected to investigate the binding to bovine serum albumin (BSA) using UV absorption spectroscopy, fluorescence spectroscopy and synchronous fluorescence spectroscopy. Chlorogenic acid 35-51 albumin Homo sapiens 131-144 20854262-2 2010 The chlorogenic acid derivative S4048 is a pharmacological inhibitor of the glucose 6-phosphate transporter, which is part of glucose-6-phosphatase, and allows for mechanistic studies concerning metabolic defects in GSD-1. Chlorogenic acid 4-20 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 216-221 20655275-2 2010 In this paper, caffeic acid (CaA), chlorogenic acid (ChA) and ferulic acid (FA) were selected to investigate the binding to bovine serum albumin (BSA) using UV absorption spectroscopy, fluorescence spectroscopy and synchronous fluorescence spectroscopy. Chlorogenic acid 53-56 albumin Homo sapiens 131-144 20637839-0 2010 Chlorogenic acid suppresses pulmonary eosinophilia, IgE production, and Th2-type cytokine production in an ovalbumin-induced allergic asthma: activation of STAT-6 and JNK is inhibited by chlorogenic acid. Chlorogenic acid 0-16 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 107-116 20637839-0 2010 Chlorogenic acid suppresses pulmonary eosinophilia, IgE production, and Th2-type cytokine production in an ovalbumin-induced allergic asthma: activation of STAT-6 and JNK is inhibited by chlorogenic acid. Chlorogenic acid 0-16 signal transducer and activator of transcription 6 Mus musculus 156-162 20637839-0 2010 Chlorogenic acid suppresses pulmonary eosinophilia, IgE production, and Th2-type cytokine production in an ovalbumin-induced allergic asthma: activation of STAT-6 and JNK is inhibited by chlorogenic acid. Chlorogenic acid 0-16 mitogen-activated protein kinase 8 Mus musculus 167-170 20637839-0 2010 Chlorogenic acid suppresses pulmonary eosinophilia, IgE production, and Th2-type cytokine production in an ovalbumin-induced allergic asthma: activation of STAT-6 and JNK is inhibited by chlorogenic acid. Chlorogenic acid 187-203 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 107-116 20637839-0 2010 Chlorogenic acid suppresses pulmonary eosinophilia, IgE production, and Th2-type cytokine production in an ovalbumin-induced allergic asthma: activation of STAT-6 and JNK is inhibited by chlorogenic acid. Chlorogenic acid 187-203 signal transducer and activator of transcription 6 Mus musculus 156-162 20637839-0 2010 Chlorogenic acid suppresses pulmonary eosinophilia, IgE production, and Th2-type cytokine production in an ovalbumin-induced allergic asthma: activation of STAT-6 and JNK is inhibited by chlorogenic acid. Chlorogenic acid 187-203 mitogen-activated protein kinase 8 Mus musculus 167-170 21246835-0 2010 [Study of immunogenicity of chlorogenic acid-BSA with different number of CGA]. Chlorogenic acid 28-44 chromogranin A Mus musculus 74-77 21246835-1 2010 OBJECTIVE: To investigate the immunogenicity of chlorogenic acid-BSA(CGA-BSA) and the foundation for the allergization of CGA-BSA. Chlorogenic acid 48-64 chromogranin A Mus musculus 69-72 21246835-1 2010 OBJECTIVE: To investigate the immunogenicity of chlorogenic acid-BSA(CGA-BSA) and the foundation for the allergization of CGA-BSA. Chlorogenic acid 48-64 chromogranin A Mus musculus 122-125 20580705-2 2010 The present study investigated whether baicalin, baicalein, chlorogenic acid, and ginsenoside Rf induced the expression of the cytochrome P450 3A4 (CYP3A4) and multi-drug resistance 1 (MDR1) genes through the pregnane X receptor and constitutive androstane receptor pathways. Chlorogenic acid 60-76 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 127-146 20832390-0 2010 Involvement of ROS in chlorogenic acid-induced apoptosis of Bcr-Abl+ CML cells. Chlorogenic acid 22-38 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 60-67 20832390-1 2010 Chlorogenic acid (Chl) has been reported to possess a wide range of biological and pharmacological properties including induction of apoptosis of Bcr-Abl(+) chronic myeloid leukemia (CML) cell lines and clinical leukemia samples via inhibition of Bcr-Abl phosphorylation. Chlorogenic acid 0-16 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 146-153 20832390-1 2010 Chlorogenic acid (Chl) has been reported to possess a wide range of biological and pharmacological properties including induction of apoptosis of Bcr-Abl(+) chronic myeloid leukemia (CML) cell lines and clinical leukemia samples via inhibition of Bcr-Abl phosphorylation. Chlorogenic acid 0-16 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 247-254 20832390-1 2010 Chlorogenic acid (Chl) has been reported to possess a wide range of biological and pharmacological properties including induction of apoptosis of Bcr-Abl(+) chronic myeloid leukemia (CML) cell lines and clinical leukemia samples via inhibition of Bcr-Abl phosphorylation. Chlorogenic acid 0-3 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 146-153 20832390-1 2010 Chlorogenic acid (Chl) has been reported to possess a wide range of biological and pharmacological properties including induction of apoptosis of Bcr-Abl(+) chronic myeloid leukemia (CML) cell lines and clinical leukemia samples via inhibition of Bcr-Abl phosphorylation. Chlorogenic acid 0-3 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 247-254 20832390-6 2010 Knocking down DR5 using siRNA completely attenuated Chl-induced caspase-8 cleavage but partially inhibited apoptosis. Chlorogenic acid 52-55 TNF receptor superfamily member 10b Homo sapiens 14-17 20832390-6 2010 Knocking down DR5 using siRNA completely attenuated Chl-induced caspase-8 cleavage but partially inhibited apoptosis. Chlorogenic acid 52-55 caspase 8 Homo sapiens 64-73 20832390-7 2010 Antioxidant NAC attenuated Chl-induced oxidative stress-mediated inhibition of Bcr-Abl phosphorylation, DR5 upregulation, caspase activation and CML cell death. Chlorogenic acid 27-30 synuclein alpha Homo sapiens 12-15 20832390-7 2010 Antioxidant NAC attenuated Chl-induced oxidative stress-mediated inhibition of Bcr-Abl phosphorylation, DR5 upregulation, caspase activation and CML cell death. Chlorogenic acid 27-30 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 79-86 20832390-7 2010 Antioxidant NAC attenuated Chl-induced oxidative stress-mediated inhibition of Bcr-Abl phosphorylation, DR5 upregulation, caspase activation and CML cell death. Chlorogenic acid 27-30 TNF receptor superfamily member 10b Homo sapiens 104-107 20580705-0 2010 Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor- and pregnane X receptor-mediated pathways. Chlorogenic acid 69-86 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 13-19 20580705-0 2010 Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor- and pregnane X receptor-mediated pathways. Chlorogenic acid 69-86 ATP binding cassette subfamily B member 1 Homo sapiens 24-28 19937041-0 2010 Chlorogenic acid attenuates adhesion molecules upregulation in IL-1beta-treated endothelial cells. Chlorogenic acid 0-16 interleukin 1 beta Homo sapiens 63-71 19937041-6 2010 Chlorogenic acid dose-dependently suppressed IL-1beta-induced mRNA expression of vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1 and endothelial cell selectin. Chlorogenic acid 0-16 interleukin 1 beta Homo sapiens 45-53 19937041-6 2010 Chlorogenic acid dose-dependently suppressed IL-1beta-induced mRNA expression of vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1 and endothelial cell selectin. Chlorogenic acid 0-16 vascular cell adhesion molecule 1 Homo sapiens 81-114 19937041-7 2010 Chlorogenic acid also suppressed the IL-1beta-induced production of ROS. Chlorogenic acid 0-16 interleukin 1 beta Homo sapiens 37-45 19937041-8 2010 We also observed that chlorogenic acid attenuated or blocked IL-1beta-induced nuclear translocation of nuclear factor-kappaB subunits p50 and p65, which in turn attenuated CAM expression at the transcription level. Chlorogenic acid 22-38 interleukin 1 beta Homo sapiens 61-69 19937041-8 2010 We also observed that chlorogenic acid attenuated or blocked IL-1beta-induced nuclear translocation of nuclear factor-kappaB subunits p50 and p65, which in turn attenuated CAM expression at the transcription level. Chlorogenic acid 22-38 nuclear factor kappa B subunit 1 Homo sapiens 134-137 19937041-8 2010 We also observed that chlorogenic acid attenuated or blocked IL-1beta-induced nuclear translocation of nuclear factor-kappaB subunits p50 and p65, which in turn attenuated CAM expression at the transcription level. Chlorogenic acid 22-38 RELA proto-oncogene, NF-kB subunit Homo sapiens 142-145 19937041-9 2010 Furthermore, chlorogenic acid significantly reduced the adhesion of human monocyte cells (U937) to IL-1beta-treated HUVECs in a dose-response manner. Chlorogenic acid 13-29 interleukin 1 beta Homo sapiens 99-107 20580705-2 2010 The present study investigated whether baicalin, baicalein, chlorogenic acid, and ginsenoside Rf induced the expression of the cytochrome P450 3A4 (CYP3A4) and multi-drug resistance 1 (MDR1) genes through the pregnane X receptor and constitutive androstane receptor pathways. Chlorogenic acid 60-76 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 148-154 20580705-2 2010 The present study investigated whether baicalin, baicalein, chlorogenic acid, and ginsenoside Rf induced the expression of the cytochrome P450 3A4 (CYP3A4) and multi-drug resistance 1 (MDR1) genes through the pregnane X receptor and constitutive androstane receptor pathways. Chlorogenic acid 60-76 ATP binding cassette subfamily B member 1 Homo sapiens 160-183 20580705-2 2010 The present study investigated whether baicalin, baicalein, chlorogenic acid, and ginsenoside Rf induced the expression of the cytochrome P450 3A4 (CYP3A4) and multi-drug resistance 1 (MDR1) genes through the pregnane X receptor and constitutive androstane receptor pathways. Chlorogenic acid 60-76 ATP binding cassette subfamily B member 1 Homo sapiens 185-189 20580705-2 2010 The present study investigated whether baicalin, baicalein, chlorogenic acid, and ginsenoside Rf induced the expression of the cytochrome P450 3A4 (CYP3A4) and multi-drug resistance 1 (MDR1) genes through the pregnane X receptor and constitutive androstane receptor pathways. Chlorogenic acid 60-76 nuclear receptor subfamily 1 group I member 2 Homo sapiens 209-228 20580705-4 2010 The interactions of baicalein/chlorogenic acid/ginsenoside Rf with constitutive androstane receptor and pregnane X receptor were evaluated using luciferase reporter and gel shift assays. Chlorogenic acid 30-46 nuclear receptor subfamily 1 group I member 2 Homo sapiens 104-123 20580705-6 2010 Chlorogenic acid and ginsenoside Rf showed a relatively weak effect on CYP3A4 promoter activation only in HepG2 cells cotransfected with constitutive androstane receptor and demonstrated no effects on MDR1 via either the constitutive androstane receptor or pregnane X receptor pathway. Chlorogenic acid 0-16 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 71-77 20580705-6 2010 Chlorogenic acid and ginsenoside Rf showed a relatively weak effect on CYP3A4 promoter activation only in HepG2 cells cotransfected with constitutive androstane receptor and demonstrated no effects on MDR1 via either the constitutive androstane receptor or pregnane X receptor pathway. Chlorogenic acid 0-16 nuclear receptor subfamily 1 group I member 2 Homo sapiens 257-276 20580705-9 2010 Chlorogenic acid and ginsenoside Rf only induced constitutive androstane receptor-mediated CYP3A4 expression. Chlorogenic acid 0-16 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 91-97 20522176-10 2010 Different inhibitory effects of NaN(3), EDTA, KCN, and L-cysteine, as well as different impacts of a variety of cations on the oxidation of chlorogenic acid, mediated by PPO or POD, were detected. Chlorogenic acid 140-156 Polyphenol oxidase, chloroplastic Zea mays 170-173 20387813-4 2010 Bovine serum albumin (BSA) increased the oxidative stability of LDL in the presence of chlorogenic acid. Chlorogenic acid 87-103 albumin Homo sapiens 7-20 20522176-10 2010 Different inhibitory effects of NaN(3), EDTA, KCN, and L-cysteine, as well as different impacts of a variety of cations on the oxidation of chlorogenic acid, mediated by PPO or POD, were detected. Chlorogenic acid 140-156 peroxidase 1 Zea mays 177-180 20196602-5 2010 In iron- and myoglobin-oxidized suspensions, however, some of those phenolic compounds (i.e., chlorogenic acid and genistein) promoted the formation of the semialdehydes. Chlorogenic acid 94-110 myoglobin Homo sapiens 13-22 20707079-1 2010 OBJECTIVE: To investigate the sensitization and mechanism of artificial antigen of chlorogenic acid (CGA-BSA). Chlorogenic acid 83-99 glycoprotein hormones alpha chain Cavia porcellus 101-104 20302380-0 2010 Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. Chlorogenic acid 16-33 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 69-90 20064576-5 2010 Triglyceride content in adipose tissue was significantly lowered, whereas the plasma adiponectin level was elevated by chlorogenic acid supplementation compared to the high-fat control group. Chlorogenic acid 119-135 adiponectin, C1Q and collagen domain containing Mus musculus 85-96 19629962-4 2010 Among the six natural products screened, five compounds, caffeic acid, caffeoyl acetate, ferulic acid, chlorogenic acid and resveratrol indicated potent in vitro ACE inhibitory activity with IC(50) values of 2.527 +/- 0.032, 3.129 +/- 0.016, 10.898 +/- 0.430, 15.076 +/- 1.211 and 6.359 +/- 0.086 mm, respectively. Chlorogenic acid 103-119 angiotensin I converting enzyme Homo sapiens 162-165 19660925-8 2009 Expression of GLUT4 and PPAR-gamma gene were elevated in chlorogenic acid and berberine treated cells, whereas expression of GLUT4 and PI3K transcripts were significantly enhanced in ferulic acid treated cells. Chlorogenic acid 57-73 solute carrier family 2 member 4 Homo sapiens 14-19 19660925-8 2009 Expression of GLUT4 and PPAR-gamma gene were elevated in chlorogenic acid and berberine treated cells, whereas expression of GLUT4 and PI3K transcripts were significantly enhanced in ferulic acid treated cells. Chlorogenic acid 57-73 peroxisome proliferator activated receptor gamma Homo sapiens 24-34 19660925-9 2009 The studies indicate that chlorogenic acid enhances glucose uptake by increasing GLUT4 expression via PI3K independent pathway whereas ferulic acid increases glucose uptake by PI3K dependent pathway. Chlorogenic acid 26-42 solute carrier family 2 member 4 Homo sapiens 81-86 19028509-3 2009 In this study, we investigated the protective effects of chlorogenic acid (5-O-caffeoylquinic acid; CGA), a major phenolic phytochemical found in instant decaffeinated coffee (IDC), and IDC against oxidative PC12 neuronal cell death. Chlorogenic acid 57-73 chromogranin A Rattus norvegicus 100-103 19324944-4 2009 RESULTS: Chlorogenic acid and trigonelline ingestion significantly reduced glucose (-0.7 mmol/l, P = 0.007, and -0.5 mmol/l, P = 0.024, respectively) and insulin (-73 pmol/l, P = 0.038, and -117 pmol/l, P = 0.007) concentrations 15 min following an OGTT compared with placebo. Chlorogenic acid 9-25 insulin Homo sapiens 154-161 19324944-6 2009 CONCLUSIONS: Chlorogenic acid and trigonelline reduced early glucose and insulin responses during an OGTT. Chlorogenic acid 13-29 insulin Homo sapiens 73-80 19248222-0 2009 Chlorogenic acid protects paraoxonase 1 activity in high density lipoprotein from inactivation caused by physiological concentrations of hypochlorite. Chlorogenic acid 0-16 paraoxonase 1 Homo sapiens 26-39 19393773-0 2009 Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-kappaB and JNK/AP-1 activation. Chlorogenic acid 0-16 prostaglandin-endoperoxide synthase 2 Mus musculus 53-69 19393773-0 2009 Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-kappaB and JNK/AP-1 activation. Chlorogenic acid 0-16 mitogen-activated protein kinase 8 Mus musculus 133-136 16566826-0 2006 The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression. Chlorogenic acid 34-50 solute carrier family 37 member 4 Homo sapiens 98-129 19073879-6 2009 Fyn kinase activity was suppressed more effectively by caffeic acid than by chlorogenic acid, and downstream mitogen-activated protein kinases (MAPKs) were subsequently blocked. Chlorogenic acid 76-92 FYN proto-oncogene, Src family tyrosine kinase Homo sapiens 0-3 18597699-4 2008 Pump activity of the thoracic ducts in 0 mm glucose was completely inhibited in the presence of chlorogenic acid (an inhibitor of glucose-6-phosphatase). Chlorogenic acid 96-112 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 130-151 18267120-3 2008 Chlorogenic acid and (-)-epigallocatechin-3-gallate, two diet-derived inhibitors of G6PT and of MT1-MMP, respectively, reduced S1P-mediated Ca(2+) mobilization. Chlorogenic acid 0-16 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 84-88 18267120-3 2008 Chlorogenic acid and (-)-epigallocatechin-3-gallate, two diet-derived inhibitors of G6PT and of MT1-MMP, respectively, reduced S1P-mediated Ca(2+) mobilization. Chlorogenic acid 0-16 matrix metallopeptidase 14 Homo sapiens 96-103 18167444-4 2007 The squalene synthase inhibitor was identified as chlorogenic acid with a molecular mass of 354 Da and a molecular formula of C16H18O9 based on UV spectrophotometry, 1H and 13C NMRs, and mass spectrometry. Chlorogenic acid 50-66 farnesyl-diphosphate farnesyltransferase 1 Sus scrofa 4-21 18167444-5 2007 Chlorogenic acid inhibited the squalene synthase of pig liver with an IC50 level of 100 nM. Chlorogenic acid 0-16 farnesyl-diphosphate farnesyltransferase 1 Sus scrofa 31-48 18167444-6 2007 Since chlorogenic acid was an effective inhibitor against the squalene synthase of an animal source, it may be a potential therapeutic agent for hypercholesterolemia. Chlorogenic acid 6-22 farnesyl-diphosphate farnesyltransferase 1 Sus scrofa 62-79 17263495-0 2007 Profiling the chlorogenic acids and other caffeic acid derivatives of herbal chrysanthemum by LC-MSn. Chlorogenic acid 14-31 moesin Homo sapiens 97-100 17157178-5 2006 Both chlorogenic acid and bovine serum albumin, representative of a phenol- and a protein-rich meal, respectively, were able to spare uric acid, although chlorogenic acid increased, whereas bovine serum albumin inhibited, *NO release. Chlorogenic acid 5-21 albumin Homo sapiens 197-210 16616263-10 2006 In contrast mutants defective in light perception such as the high pigment (hp-1) and LA3771 possess elevated chlorogenic acid and rutin as well as increased carotenoid content. Chlorogenic acid 110-126 DNA damage-binding protein 1 Solanum lycopersicum 76-80 19248222-1 2009 We hypothesized that chlorogenic acids, the main phenolics in coffee, many fruits and Ilex paraguariensis extracts, protect paraoxonase 1 activity in HDL from inactivation by chlorination at concentrations of HOCl (50 microM) and chlorogenic acid (2-10 microM) compatible with those found in humans. Chlorogenic acid 21-38 paraoxonase 1 Homo sapiens 124-137 19248222-1 2009 We hypothesized that chlorogenic acids, the main phenolics in coffee, many fruits and Ilex paraguariensis extracts, protect paraoxonase 1 activity in HDL from inactivation by chlorination at concentrations of HOCl (50 microM) and chlorogenic acid (2-10 microM) compatible with those found in humans. Chlorogenic acid 21-37 paraoxonase 1 Homo sapiens 124-137 19095062-2 2009 When human liver COMT was used as the enzyme, chlorogenic acid and caffeic acid each inhibited the O-methylation of 2-OH-E(2) in a concentration-dependent manner, with IC(50) values of 1.3-1.4 and 6.3-12.5 microM, respectively, and they also inhibited the O-methylation of 4-OH-E(2), with IC(50) values of 0.7-0.8 and 1.3-3.1 microM, respectively. Chlorogenic acid 46-62 catechol-O-methyltransferase Homo sapiens 17-21 19095062-5 2009 Enzyme kinetic analyses showed that chlorogenic acid and caffeic acid inhibited the human liver and placental COMT-mediated O-methylation of catechol estrogens with a mixed mechanism of inhibition (competitive plus noncompetitive). Chlorogenic acid 36-52 catechol-O-methyltransferase Homo sapiens 110-114 19095062-6 2009 Computational molecular modeling analysis showed that chlorogenic acid and caffeic acid can bind to human soluble COMT at the active site in a similar manner as the catechol estrogen substrates. Chlorogenic acid 54-70 catechol-O-methyltransferase Homo sapiens 114-118 18783210-0 2008 Chlorogenic acid derivatives with alkyl chains of different lengths and orientations: potent alpha-glucosidase inhibitors. Chlorogenic acid 0-16 sucrase-isomaltase Homo sapiens 93-110 18783210-3 2008 Here, we report the synthesis and alpha-glucosidase inhibitory activity of mono- and diketal/acetal derivatives of chlorogenic acid. Chlorogenic acid 115-131 sucrase-isomaltase Homo sapiens 34-51 18448837-3 2008 Here, we report the effect of three coffee constituents, chlorogenic acid, caffeine, and N-methyl pyridinium ions, on the expression of the histamine receptor H2, the acetylcholine receptor M3, the gastrin receptor, the somatostatin receptor, and the H+,K+-ATPase. Chlorogenic acid 57-73 histamine receptor H2 Homo sapiens 140-192 18448837-3 2008 Here, we report the effect of three coffee constituents, chlorogenic acid, caffeine, and N-methyl pyridinium ions, on the expression of the histamine receptor H2, the acetylcholine receptor M3, the gastrin receptor, the somatostatin receptor, and the H+,K+-ATPase. Chlorogenic acid 57-73 cholecystokinin B receptor Homo sapiens 198-214 18506224-6 2008 The K(m) values of the PPO for caffeic acid, chlorogenic acid, pyrocatechol, 4-methyl catechol and l-DOPA as substrates were 0.077, 0.198, 1.176, 1.667 and 4.545 mM. Chlorogenic acid 45-61 polyphenol oxidase I, chloroplastic Triticum aestivum 23-26 17613171-0 2007 Calmodulin-dependent activation of calcineurin by chlorogenic acid. Chlorogenic acid 50-66 calmodulin 1 Homo sapiens 0-10 17157178-5 2006 Both chlorogenic acid and bovine serum albumin, representative of a phenol- and a protein-rich meal, respectively, were able to spare uric acid, although chlorogenic acid increased, whereas bovine serum albumin inhibited, *NO release. Chlorogenic acid 154-170 albumin Homo sapiens 33-46 16820341-0 2006 The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Chlorogenic acid 49-65 brain expressed associated with NEDD4 1 Homo sapiens 84-88 16820341-1 2006 Chlorogenic acids (CGA) in green coffee bean extract (GCE) reduce blood pressure in spontaneously hypertensive rats and humans. Chlorogenic acid 0-17 brain expressed, associated with NEDD4, 1 Rattus norvegicus 40-44 16081510-2 2006 Under conditions that were suitable for the in vitro enzymatic methylation of DNA and dietary catechols, we found that the presence of caffeic acid or chlorogenic acid inhibited in a concentration-dependent manner the DNA methylation catalyzed by prokaryotic M.SssI DNA methyltransferase (DNMT) and human DNMT1. Chlorogenic acid 151-167 DNA methyltransferase 1 Homo sapiens 266-287 16081510-2 2006 Under conditions that were suitable for the in vitro enzymatic methylation of DNA and dietary catechols, we found that the presence of caffeic acid or chlorogenic acid inhibited in a concentration-dependent manner the DNA methylation catalyzed by prokaryotic M.SssI DNA methyltransferase (DNMT) and human DNMT1. Chlorogenic acid 151-167 DNA methyltransferase 1 Homo sapiens 289-293 16081510-2 2006 Under conditions that were suitable for the in vitro enzymatic methylation of DNA and dietary catechols, we found that the presence of caffeic acid or chlorogenic acid inhibited in a concentration-dependent manner the DNA methylation catalyzed by prokaryotic M.SssI DNA methyltransferase (DNMT) and human DNMT1. Chlorogenic acid 151-167 DNA methyltransferase 1 Homo sapiens 305-310 16081510-3 2006 The IC50 values of caffeic acid and chlorogenic acid were 3.0 and 0.75 microM, respectively, for the inhibition of M.SssI DNMT-mediated DNA methylation, and were 2.3 and 0.9 microM, respectively, for the inhibition of human DNMT1-mediated DNA methylation. Chlorogenic acid 36-52 DNA methyltransferase 1 Homo sapiens 122-126 16081510-3 2006 The IC50 values of caffeic acid and chlorogenic acid were 3.0 and 0.75 microM, respectively, for the inhibition of M.SssI DNMT-mediated DNA methylation, and were 2.3 and 0.9 microM, respectively, for the inhibition of human DNMT1-mediated DNA methylation. Chlorogenic acid 36-52 DNA methyltransferase 1 Homo sapiens 224-229 16081510-6 2006 The presence of caffeic acid or chlorogenic acid inhibited DNA methylation predominantly through a non-competitive mechanism, and this inhibition was largely due to the increased formation of S-adenosyl-L-homocysteine (SAH, a potent inhibitor of DNA methylation), resulting from the catechol-O-methyltransferase (COMT)-mediated O-methylation of these dietary catechols. Chlorogenic acid 32-48 catechol-O-methyltransferase Homo sapiens 283-311 16081510-6 2006 The presence of caffeic acid or chlorogenic acid inhibited DNA methylation predominantly through a non-competitive mechanism, and this inhibition was largely due to the increased formation of S-adenosyl-L-homocysteine (SAH, a potent inhibitor of DNA methylation), resulting from the catechol-O-methyltransferase (COMT)-mediated O-methylation of these dietary catechols. Chlorogenic acid 32-48 catechol-O-methyltransferase Homo sapiens 313-317 16081510-7 2006 Using cultured MCF-7 and MAD-MB-231 human breast cancer cells, we also demonstrated that treatment of these cells with caffeic acid or chlorogenic acid partially inhibited the methylation of the promoter region of the RARbeta gene. Chlorogenic acid 135-151 retinoic acid receptor beta Homo sapiens 218-225 16566826-1 2006 BACKGROUND: Chlorogenic acid (CHL), the most potent functional inhibitor of the microsomal glucose-6-phosphate translocase (G6PT), is thought to possess cancer chemopreventive properties. Chlorogenic acid 12-28 solute carrier family 37 member 4 Homo sapiens 91-122 16566826-1 2006 BACKGROUND: Chlorogenic acid (CHL), the most potent functional inhibitor of the microsomal glucose-6-phosphate translocase (G6PT), is thought to possess cancer chemopreventive properties. Chlorogenic acid 12-28 solute carrier family 37 member 4 Homo sapiens 124-128 16566826-1 2006 BACKGROUND: Chlorogenic acid (CHL), the most potent functional inhibitor of the microsomal glucose-6-phosphate translocase (G6PT), is thought to possess cancer chemopreventive properties. Chlorogenic acid 30-33 solute carrier family 37 member 4 Homo sapiens 91-122 16566826-1 2006 BACKGROUND: Chlorogenic acid (CHL), the most potent functional inhibitor of the microsomal glucose-6-phosphate translocase (G6PT), is thought to possess cancer chemopreventive properties. Chlorogenic acid 30-33 solute carrier family 37 member 4 Homo sapiens 124-128 16169204-0 2006 Insulin receptor exon 11+/- is expressed in Zucker (fa/fa) rats, and chlorogenic acid modifies their plasma insulin and liver protein and DNA. Chlorogenic acid 69-85 insulin receptor Rattus norvegicus 0-16 16551686-9 2006 Analysis of the soluble phenolic fraction by HPLC-MS revealed that vegetative organs of CCR down-regulated plants contained higher amounts of chlorogenic acid and rutin, and accumulated new metabolites undetectable in the wild type, such as N-caffeoyl putrescine and kaempferol rutinoside. Chlorogenic acid 142-158 cinnamoyl-CoA reductase Solanum lycopersicum 88-91 15944151-7 2005 At low concentrations, chlorogenic acid decreased the phosphorylation of c-Jun NH2-terminal kinases, p38 kinase, and MAPK kinase 4 induced by UVB/12-O-tetradecanoylphorbol-13-acetate, yet higher doses were required to inhibit extracellular signal-regulated kinases. Chlorogenic acid 23-39 mitogen-activated protein kinase 14 Homo sapiens 101-104 15944151-8 2005 Chlorogenic acid also increased the enzymatic activities of glutathione S-transferases (GST) and NAD(P)H: quinone oxidoreductase. Chlorogenic acid 0-16 crystallin zeta Homo sapiens 106-128 15944151-9 2005 Further studies indicated that chlorogenic acid could stimulate the nuclear translocation of Nrf2 (NF-E2-related factor) as well as subsequent induction of GSTA1 antioxidant response element (ARE)-mediated GST activity. Chlorogenic acid 31-47 NFE2 like bZIP transcription factor 2 Homo sapiens 93-97 15944151-9 2005 Further studies indicated that chlorogenic acid could stimulate the nuclear translocation of Nrf2 (NF-E2-related factor) as well as subsequent induction of GSTA1 antioxidant response element (ARE)-mediated GST activity. Chlorogenic acid 31-47 glutathione S-transferase alpha 1 Homo sapiens 156-161 15659385-6 2005 We identified chlorogenic acid as a specific IPMK inhibitor whereas the flavonoids myricetin, 3",4",7,8-tetrahydroxyflavone and EGCG inhibit preferentially IP3K-A and IP3K-C. Chlorogenic acid 14-30 inositol polyphosphate multikinase Homo sapiens 45-49 15694706-0 2005 A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk. Chlorogenic acid 2-18 glucagon like peptide 1 receptor Homo sapiens 39-44 15694706-4 2005 Indeed, there is recent evidence that coffee increases production of the incretin hormone glucagon-like peptide-1 (GLP-1), possibly owing to an inhibitory effect of chlorogenic acid (CGA -- the chief polyphenol in coffee) on glucose absorption. Chlorogenic acid 165-181 glucagon like peptide 1 receptor Homo sapiens 115-120 15694706-4 2005 Indeed, there is recent evidence that coffee increases production of the incretin hormone glucagon-like peptide-1 (GLP-1), possibly owing to an inhibitory effect of chlorogenic acid (CGA -- the chief polyphenol in coffee) on glucose absorption. Chlorogenic acid 165-181 chromogranin A Homo sapiens 183-186 15315393-5 2004 3,5-DiCQA and 5-CQA with an apple acetone powder (AP) containing polyphenol oxidase showed high capturing activities toward thiols, and two addition compounds between 3,5-diCQA and methane thiol were also identified. Chlorogenic acid 14-19 polyphenol oxidase, chloroplastic Malus domestica 65-83 15226183-0 2004 Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells. Chlorogenic acid 0-16 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 26-33 15226183-0 2004 Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells. Chlorogenic acid 0-16 mitogen-activated protein kinase 14 Homo sapiens 63-99 15226183-1 2004 We report that chlorogenic acid (Chl) induces apoptosis of several Bcr-Abl-positive chronic myelogenous leukemia (CML) cell lines and primary cells from CML patients in vitro and destroys Bcr-Abl-positive K562 cells in vivo. Chlorogenic acid 15-31 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 67-74 15226183-1 2004 We report that chlorogenic acid (Chl) induces apoptosis of several Bcr-Abl-positive chronic myelogenous leukemia (CML) cell lines and primary cells from CML patients in vitro and destroys Bcr-Abl-positive K562 cells in vivo. Chlorogenic acid 15-31 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 188-195 15226183-1 2004 We report that chlorogenic acid (Chl) induces apoptosis of several Bcr-Abl-positive chronic myelogenous leukemia (CML) cell lines and primary cells from CML patients in vitro and destroys Bcr-Abl-positive K562 cells in vivo. Chlorogenic acid 33-36 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 67-74 15226183-1 2004 We report that chlorogenic acid (Chl) induces apoptosis of several Bcr-Abl-positive chronic myelogenous leukemia (CML) cell lines and primary cells from CML patients in vitro and destroys Bcr-Abl-positive K562 cells in vivo. Chlorogenic acid 33-36 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 188-195 12832153-6 2003 Chlorogenic acid was the least effective inhibitor of DMBA-DNA adducts formation particularly syn-DMBADE-dAdo (20%). Chlorogenic acid 0-16 synemin Homo sapiens 94-97 15203380-3 2004 The single, topical application of 8 and 16 mumol of protocatechuic or chlorogenic acid increased the activity of AHH by 10-30%, whereas resveratrol in a dose of 16 mumol almost completely (99%) inhibited the enzyme activity. Chlorogenic acid 71-87 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 114-117 12903974-1 2003 The non-covalent interactions between the monomeric phenolic compound chlorogenic acid (5-CQA) and bovine serum albumin (BSA), lysozyme, and alpha-lactalbumin were characterized, and their effect on protein properties was examined. Chlorogenic acid 70-86 albumin Homo sapiens 106-119 12903974-1 2003 The non-covalent interactions between the monomeric phenolic compound chlorogenic acid (5-CQA) and bovine serum albumin (BSA), lysozyme, and alpha-lactalbumin were characterized, and their effect on protein properties was examined. Chlorogenic acid 70-86 lactalbumin alpha Homo sapiens 141-158 12898413-5 2003 Results showed that the water-soluble compounds, namely aucubin, chlorogenic acid, ferulic acid, p-coumaric acid and vanillic acid, enhanced the activity of human lymphocyte proliferation and secretion of IFN-gamma. Chlorogenic acid 65-81 interferon gamma Homo sapiens 205-214 12062448-2 2002 In this paper, we show that S3483, a chlorogenic acid derivative known to inhibit glucose-6-phosphatase in intact microsomes, caused the intravesicular accumulation of glucose-6-phosphate when the latter was produced by glucose-6-phosphatase from glucose and carbamoyl-phosphate. Chlorogenic acid 37-53 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 82-103 12906921-6 2003 Concomitant application of substrates transported by mrp2 such as bromosulfophthalein (BSP) or the synthetic chlorogenic acid derivative S 3025 significantly reduced the biliary appearance of normal ODN and 2BA-ODN in Wistar rats and also in TR- rats. Chlorogenic acid 109-125 ATP binding cassette subfamily C member 2 Rattus norvegicus 53-57 12062448-2 2002 In this paper, we show that S3483, a chlorogenic acid derivative known to inhibit glucose-6-phosphatase in intact microsomes, caused the intravesicular accumulation of glucose-6-phosphate when the latter was produced by glucose-6-phosphatase from glucose and carbamoyl-phosphate. Chlorogenic acid 37-53 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 220-241 11429408-7 2001 Taken together, these data show that CYP98A3 catalyzes the synthesis of chlorogenic acid and very likely also the 3-hydroxylation of lignin monomers. Chlorogenic acid 72-88 cytochrome P450, family 98, subfamily A, polypeptide 3 Arabidopsis thaliana 37-44 12022439-2 2002 Chlorogenic acid, a plant polyphenol, inhibited SE-induced T-cell proliferation (by 98%) and production of interleukin 1beta, tumor necrosis factor, interleukin 6, interferon gamma, monocyte chemotactic protein I (MCP-l), macrophage inflammatory protein (MIP)-lalpha, and MIP-lbeta by human peripheral blood mononuclear cells. Chlorogenic acid 0-16 interleukin 1 beta Homo sapiens 107-124 12022439-2 2002 Chlorogenic acid, a plant polyphenol, inhibited SE-induced T-cell proliferation (by 98%) and production of interleukin 1beta, tumor necrosis factor, interleukin 6, interferon gamma, monocyte chemotactic protein I (MCP-l), macrophage inflammatory protein (MIP)-lalpha, and MIP-lbeta by human peripheral blood mononuclear cells. Chlorogenic acid 0-16 interleukin 6 Homo sapiens 149-162 12022439-2 2002 Chlorogenic acid, a plant polyphenol, inhibited SE-induced T-cell proliferation (by 98%) and production of interleukin 1beta, tumor necrosis factor, interleukin 6, interferon gamma, monocyte chemotactic protein I (MCP-l), macrophage inflammatory protein (MIP)-lalpha, and MIP-lbeta by human peripheral blood mononuclear cells. Chlorogenic acid 0-16 capping actin protein, gelsolin like Homo sapiens 214-217 11853963-1 2002 Chlorogenic acid derivatives are potent inhibitors of hepatic glucose production by inhibition of the glucose-6-phosphate translocase component of the hepatic glucose-6-phosphatase system. Chlorogenic acid 0-16 solute carrier family 37 member 4 Rattus norvegicus 102-133 11853963-1 2002 Chlorogenic acid derivatives are potent inhibitors of hepatic glucose production by inhibition of the glucose-6-phosphate translocase component of the hepatic glucose-6-phosphatase system. Chlorogenic acid 0-16 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 159-180 11727199-1 2002 C-->U RNA editing of neurofibromatosis 1 (NF1) mRNA changes an arginine (CGA) to a UGA translational stop codon, predicted to result in translational termination of the edited mRNA. Chlorogenic acid 76-79 neurofibromin 1 Homo sapiens 24-43 11727199-1 2002 C-->U RNA editing of neurofibromatosis 1 (NF1) mRNA changes an arginine (CGA) to a UGA translational stop codon, predicted to result in translational termination of the edited mRNA. Chlorogenic acid 76-79 neurofibromin 1 Homo sapiens 45-48 11742529-4 2002 In addition, the reaction of 13-HPODE with cytochrome c was inhibited by chlorogenic acid, caffeic acid and ferulic acid via two possible mechanisms, i.e. reducing cytochrome c (chlorogenic acid and caffeic acid) and scavenging the radical intermediates (chlorogenic acid, caffeic acid and ferulic acid). Chlorogenic acid 73-89 cytochrome c, somatic Homo sapiens 43-55 11742529-4 2002 In addition, the reaction of 13-HPODE with cytochrome c was inhibited by chlorogenic acid, caffeic acid and ferulic acid via two possible mechanisms, i.e. reducing cytochrome c (chlorogenic acid and caffeic acid) and scavenging the radical intermediates (chlorogenic acid, caffeic acid and ferulic acid). Chlorogenic acid 73-89 cytochrome c, somatic Homo sapiens 164-176 11742529-4 2002 In addition, the reaction of 13-HPODE with cytochrome c was inhibited by chlorogenic acid, caffeic acid and ferulic acid via two possible mechanisms, i.e. reducing cytochrome c (chlorogenic acid and caffeic acid) and scavenging the radical intermediates (chlorogenic acid, caffeic acid and ferulic acid). Chlorogenic acid 178-194 cytochrome c, somatic Homo sapiens 43-55 11742529-4 2002 In addition, the reaction of 13-HPODE with cytochrome c was inhibited by chlorogenic acid, caffeic acid and ferulic acid via two possible mechanisms, i.e. reducing cytochrome c (chlorogenic acid and caffeic acid) and scavenging the radical intermediates (chlorogenic acid, caffeic acid and ferulic acid). Chlorogenic acid 178-194 cytochrome c, somatic Homo sapiens 43-55 11346646-2 2001 Effects of acute inhibition of glucose-6-phosphatase activity by the chlorogenic acid derivative S4048 on hepatic carbohydrate fluxes were examined in isolated rat hepatocytes and in vivo in rats. Chlorogenic acid 69-85 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 31-52 11439108-4 2001 This transport activity is unrelated to G6PT1 since: (i) it was similar in microsomes of skin fibroblasts from glycogen storage disease type 1b patients homozygous for mutations of the G6PT1 gene, and in microsomes from human control subjects; (ii) it was insensitive to the G6PT1 inhibitor chlorogenic acid; and (iii) it was equally active towards G6P and glucose 1-phosphate, whereas G6PT1 is highly selective for G6P. Chlorogenic acid 291-307 solute carrier family 37 member 4 Homo sapiens 185-190 11439108-4 2001 This transport activity is unrelated to G6PT1 since: (i) it was similar in microsomes of skin fibroblasts from glycogen storage disease type 1b patients homozygous for mutations of the G6PT1 gene, and in microsomes from human control subjects; (ii) it was insensitive to the G6PT1 inhibitor chlorogenic acid; and (iii) it was equally active towards G6P and glucose 1-phosphate, whereas G6PT1 is highly selective for G6P. Chlorogenic acid 291-307 solute carrier family 37 member 4 Homo sapiens 185-190 11439108-4 2001 This transport activity is unrelated to G6PT1 since: (i) it was similar in microsomes of skin fibroblasts from glycogen storage disease type 1b patients homozygous for mutations of the G6PT1 gene, and in microsomes from human control subjects; (ii) it was insensitive to the G6PT1 inhibitor chlorogenic acid; and (iii) it was equally active towards G6P and glucose 1-phosphate, whereas G6PT1 is highly selective for G6P. Chlorogenic acid 291-307 solute carrier family 37 member 4 Homo sapiens 185-190 11359348-6 2001 In fact, certain new drugs being developed for diabetes therapy - chlorogenic acid derivatives and "compound A" - are potent inhibitors of glucose-6-phosphatase, and both AICA riboside and 2,5-anhydro-D-mannitol have potential as clinical inhibitors of fructosediphosphatase. Chlorogenic acid 66-82 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 139-160 10871299-6 2000 In addition, three other constituents, hypericin, quercetin, and chlorogenic acid, were tested for inhibitory activity toward the CYP enzymes. Chlorogenic acid 65-81 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 130-133 11123367-1 2001 Chlorogenic acid derivatives were recently identified as novel, potent, and specific inhibitors of the hepatic glucose 6-phosphate translocase. Chlorogenic acid 0-16 solute carrier family 37 member 4 Homo sapiens 111-142 11123367-2 2001 Inhibition of the glucose 6-phosphate translocase leads to a decrease in hepatic glucose production, rendering chlorogenic acid derivatives as potential novel therapeutics in patients with type 2 diabetes. Chlorogenic acid 111-127 solute carrier family 37 member 4 Homo sapiens 18-49 11123367-9 2001 A comparison of the inhibition pattern obtained in hepatocytes compared with that obtained in Oatp1-expressing Chinese hamster ovary cells suggests that facilitated uptake by Oatp1 is a major contributor in total hepatic uptake of chlorogenic acid derivatives. Chlorogenic acid 231-247 solute carrier organic anion transporter family member 4A1 L homeolog Xenopus laevis 94-99 11123367-9 2001 A comparison of the inhibition pattern obtained in hepatocytes compared with that obtained in Oatp1-expressing Chinese hamster ovary cells suggests that facilitated uptake by Oatp1 is a major contributor in total hepatic uptake of chlorogenic acid derivatives. Chlorogenic acid 231-247 solute carrier organic anion transporter family member 4A1 L homeolog Xenopus laevis 175-180 11194177-1 2000 Millimolar concentrations of chlorogenic acid (CGA) showed higher cytotoxic activity against human oral squamous cell carcinoma (HSC-2) and salivary gland tumor (HSG) cell lines, as compared with that against human gingival fibroblast (HGF). Chlorogenic acid 29-45 hepatocyte growth factor Homo sapiens 236-239 11194177-1 2000 Millimolar concentrations of chlorogenic acid (CGA) showed higher cytotoxic activity against human oral squamous cell carcinoma (HSC-2) and salivary gland tumor (HSG) cell lines, as compared with that against human gingival fibroblast (HGF). Chlorogenic acid 47-50 hepatocyte growth factor Homo sapiens 236-239 9003513-0 1997 Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase. Chlorogenic acid 0-16 solute carrier family 37 member 4 Rattus norvegicus 89-120 10226534-1 1999 The possible effects of naturally occurring plant phenolics, caffeic acid (CA), chlorogenic acid (CGA) and ferulic acid (FA) on arylamine N-acetyltransferase (NAT) activities on human gastrointestinal microflora, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter koseri and Pseudomonas aeruginosa, were examined. Chlorogenic acid 80-96 bromodomain containing 2 Homo sapiens 159-162 10226534-1 1999 The possible effects of naturally occurring plant phenolics, caffeic acid (CA), chlorogenic acid (CGA) and ferulic acid (FA) on arylamine N-acetyltransferase (NAT) activities on human gastrointestinal microflora, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter koseri and Pseudomonas aeruginosa, were examined. Chlorogenic acid 98-101 bromodomain containing 2 Homo sapiens 159-162 9671114-0 1998 Effects of 3-mercaptopicolinic acid and a derivative of chlorogenic acid (S-3483) on hepatic and islet glucose-6-phosphatase activity. Chlorogenic acid 56-72 glucose-6-phosphatase, catalytic Mus musculus 103-124 9514661-0 1998 Chlorogenic acid analogue S 3483: a potent competitive inhibitor of the hepatic and renal glucose-6-phosphatase systems. Chlorogenic acid 0-16 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 90-111 9514661-1 1998 S 3483, a synthetic derivative of chlorogenic acid (CHL), was found to be a reversible, linear competitive inhibitor of the glucose-6-phosphatase (Glc-6-Pase) system in rat renal microsomes and rat and human liver microsomes. Chlorogenic acid 34-50 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 124-145 9514661-1 1998 S 3483, a synthetic derivative of chlorogenic acid (CHL), was found to be a reversible, linear competitive inhibitor of the glucose-6-phosphatase (Glc-6-Pase) system in rat renal microsomes and rat and human liver microsomes. Chlorogenic acid 34-50 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 147-157 9056264-0 1997 Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Chlorogenic acid 0-16 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 73-94 9056264-1 1997 We have studied the interactions of chlorogenic acid (CHL) and 2-hydroxy-5-nitrobenzaldehyde (HNB) with the components of the rat hepatic glucose 6-phosphatase (Glc-6-Pase) system. Chlorogenic acid 36-52 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 138-159 9056264-1 1997 We have studied the interactions of chlorogenic acid (CHL) and 2-hydroxy-5-nitrobenzaldehyde (HNB) with the components of the rat hepatic glucose 6-phosphatase (Glc-6-Pase) system. Chlorogenic acid 36-52 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 161-171 10620367-2 2000 We used the chlorogenic acid derivative S 3483, a reversible inhibitor of the glucose-6-phosphate (Glc-6-P) translocase component, to demonstrate for the first time upregulation of Glc-6-Pase expression in rat liver in vivo after inhibition of Glc-6-P translocase. Chlorogenic acid 12-28 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 181-191 9810264-5 1998 Results of this investigation indicate that compounds which inhibit C6 glial cell MAO enzyme activity or scavenge peroxide product include chlorogenic acid, (+)-catechin, taxifolin, (-)-epigallocatechin gallate (EGCG), fisetin, coenzyme Q0, curcumin, sesamol, morin, sesame oil, silymarin, green tea, ferulic acid, caffeic acid, and rutin hydrate. Chlorogenic acid 139-155 monoamine oxidase A Rattus norvegicus 82-85 9056264-1 1997 We have studied the interactions of chlorogenic acid (CHL) and 2-hydroxy-5-nitrobenzaldehyde (HNB) with the components of the rat hepatic glucose 6-phosphatase (Glc-6-Pase) system. Chlorogenic acid 54-57 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 138-159 9056264-1 1997 We have studied the interactions of chlorogenic acid (CHL) and 2-hydroxy-5-nitrobenzaldehyde (HNB) with the components of the rat hepatic glucose 6-phosphatase (Glc-6-Pase) system. Chlorogenic acid 54-57 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 161-171 9003513-0 1997 Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase. Chlorogenic acid 31-47 solute carrier family 37 member 4 Rattus norvegicus 89-120 9003513-3 1997 Recently, chlorogenic acid was identified as a specific inhibitor of the glucose-6-phosphate translocase component (Gl-6-P translocase) of this enzyme system in microsomes of rat liver. Chlorogenic acid 10-26 solute carrier family 37 member 4 Rattus norvegicus 73-104 8704304-2 1996 The activities of erythrocytes and liver glutathione peroxidase, and of both liver catalase and glutathione reductase, which were increased by feeding paraquat, declined to the levels in the control rats by supplementing chlorogenic acid to the paraquat diet. Chlorogenic acid 221-237 catalase Rattus norvegicus 83-91 12226468-3 1996 Leaves of PAL-overexpressing plants contained increased levels of the hydroxycinnamic acid ester chlorogenic acid but not of the flavonoid rutin, indicating that PAL is the key control point for flux into chlorogenic acid. Chlorogenic acid 97-113 phenylalanine ammonia-lyase Nicotiana tabacum 10-13 12226468-3 1996 Leaves of PAL-overexpressing plants contained increased levels of the hydroxycinnamic acid ester chlorogenic acid but not of the flavonoid rutin, indicating that PAL is the key control point for flux into chlorogenic acid. Chlorogenic acid 205-221 phenylalanine ammonia-lyase Nicotiana tabacum 10-13 12226468-3 1996 Leaves of PAL-overexpressing plants contained increased levels of the hydroxycinnamic acid ester chlorogenic acid but not of the flavonoid rutin, indicating that PAL is the key control point for flux into chlorogenic acid. Chlorogenic acid 205-221 phenylalanine ammonia-lyase Nicotiana tabacum 162-165 8704304-2 1996 The activities of erythrocytes and liver glutathione peroxidase, and of both liver catalase and glutathione reductase, which were increased by feeding paraquat, declined to the levels in the control rats by supplementing chlorogenic acid to the paraquat diet. Chlorogenic acid 221-237 glutathione-disulfide reductase Rattus norvegicus 96-117 33971495-0 2021 Chlorogenic acid is a positive regulator of MDA5, TLR7 and NF-kappaB signaling pathways mediated antiviral responses against Gammacoronavirus infection. Chlorogenic acid 0-16 interferon induced with helicase C domain 1 Homo sapiens 44-48 7889175-4 1995 We detected an additional previously uncharacterized mutation: R384G mutation, a single C-->G base substitution in the codon 384 of the exon 7 changing an arginine (CGA) to a glycine (GGA) by sequencing the CYP11B1 gene of Japanese siblings with 11 beta-OHD. Chlorogenic acid 168-171 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 210-217 8052628-3 1994 In leaf tissue, PAL level is the dominant factor regulating accumulation of the major product chlorogenic acid and overall flux into the pathway. Chlorogenic acid 94-110 phenylalanine ammonia-lyase Nicotiana tabacum 16-19 8194069-0 1994 Binding geometry, stoichiometry, and thermodynamics of cyclomalto-oligosaccharide (cyclodextrin) inclusion complex formation with chlorogenic acid, the major substrate of apple polyphenol oxidase. Chlorogenic acid 130-146 polyphenol oxidase, chloroplastic Malus domestica 177-195 24253867-3 1992 zea and other lepidopteran species previously examined, approximately 35-50% of the ingested chlorogenic acid was oxidized in the digestive system by foliar phenolic oxidases (i.e., polyphenol oxidase and peroxidase) from the tomato plant. Chlorogenic acid 93-109 peroxidase Solanum lycopersicum 205-215 33971495-0 2021 Chlorogenic acid is a positive regulator of MDA5, TLR7 and NF-kappaB signaling pathways mediated antiviral responses against Gammacoronavirus infection. Chlorogenic acid 0-16 toll like receptor 7 Homo sapiens 50-54 34856474-0 2022 Chlorogenic acid suppresses mitochondrial apoptotic effectors Bax/Bak to counteract Nod-like receptor pyrin domain 3 (NLRP3) inflammasome in thiram exposed chondrocytes. Chlorogenic acid 0-16 BCL2 associated X, apoptosis regulator Homo sapiens 62-65 33811899-0 2021 Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity. Chlorogenic acid 0-16 Kelch-like ECH-associated protein 1 Rattus norvegicus 65-70 33811899-0 2021 Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity. Chlorogenic acid 0-16 NFE2 like bZIP transcription factor 2 Rattus norvegicus 71-75 33811899-0 2021 Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity. Chlorogenic acid 0-16 heme oxygenase 1 Rattus norvegicus 76-92 33811899-2 2021 We investigated the effect of chlorogenic acid (CGA), quercetin (Qt), coenzyme Q10 (Q10) and silymarin on the expression of Keap1/Nrf2 complex and its downstream target; heme oxygenase 1 (HO-1) as well as inflammation and apoptosis in an acute liver toxicity model induced by thioacetamide (TAA). Chlorogenic acid 30-46 Kelch-like ECH-associated protein 1 Rattus norvegicus 124-129 33811899-2 2021 We investigated the effect of chlorogenic acid (CGA), quercetin (Qt), coenzyme Q10 (Q10) and silymarin on the expression of Keap1/Nrf2 complex and its downstream target; heme oxygenase 1 (HO-1) as well as inflammation and apoptosis in an acute liver toxicity model induced by thioacetamide (TAA). Chlorogenic acid 30-46 NFE2 like bZIP transcription factor 2 Rattus norvegicus 130-134 33816461-13 2021 We further elucidated that mutation in GNE resulted in upregulation of RhoA protein and Cofilin activity is downregulated, which could be rescued with Rhosin and chlorogenic acid, respectively. Chlorogenic acid 162-178 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Homo sapiens 39-42 33816461-13 2021 We further elucidated that mutation in GNE resulted in upregulation of RhoA protein and Cofilin activity is downregulated, which could be rescued with Rhosin and chlorogenic acid, respectively. Chlorogenic acid 162-178 ras homolog family member A Homo sapiens 71-75 33816461-13 2021 We further elucidated that mutation in GNE resulted in upregulation of RhoA protein and Cofilin activity is downregulated, which could be rescued with Rhosin and chlorogenic acid, respectively. Chlorogenic acid 162-178 cofilin 1 Homo sapiens 88-95 32795656-7 2020 Only CAF+TRI+CGA combination reduced the incidence, number and proliferation (Ki-67) of hepatocellular preneoplastic foci while enhanced apoptosis (cleaved caspase-3) in adjacent tissue. Chlorogenic acid 13-16 antigen identified by monoclonal antibody Ki 67 Mus musculus 78-83 32795656-7 2020 Only CAF+TRI+CGA combination reduced the incidence, number and proliferation (Ki-67) of hepatocellular preneoplastic foci while enhanced apoptosis (cleaved caspase-3) in adjacent tissue. Chlorogenic acid 13-16 caspase 3 Mus musculus 156-165 32795656-8 2020 CAF+TRI+CGA treatment also decreased hepatic oxidative stress by enhancing the antioxidant Nrf2 axis. Chlorogenic acid 8-11 caffeine susceptibility Mus musculus 0-3 32795656-8 2020 CAF+TRI+CGA treatment also decreased hepatic oxidative stress by enhancing the antioxidant Nrf2 axis. Chlorogenic acid 8-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 91-95 34638063-0 2022 The inhibitory mechanism of chlorogenic acid and its acylated derivatives on alpha-amylase and alpha-glucosidase. Chlorogenic acid 28-44 sucrase-isomaltase Homo sapiens 95-112 34856474-0 2022 Chlorogenic acid suppresses mitochondrial apoptotic effectors Bax/Bak to counteract Nod-like receptor pyrin domain 3 (NLRP3) inflammasome in thiram exposed chondrocytes. Chlorogenic acid 0-16 BCL2 antagonist/killer 1 Homo sapiens 66-69 34856474-0 2022 Chlorogenic acid suppresses mitochondrial apoptotic effectors Bax/Bak to counteract Nod-like receptor pyrin domain 3 (NLRP3) inflammasome in thiram exposed chondrocytes. Chlorogenic acid 0-16 NLR family pyrin domain containing 3 Homo sapiens 84-116 34856474-0 2022 Chlorogenic acid suppresses mitochondrial apoptotic effectors Bax/Bak to counteract Nod-like receptor pyrin domain 3 (NLRP3) inflammasome in thiram exposed chondrocytes. Chlorogenic acid 0-16 NLR family pyrin domain containing 3 Homo sapiens 118-123 34884968-6 2021 Remarkably, 5-CQA attenuated OA-induced miR-34a expression. Chlorogenic acid 12-17 microRNA 34a Homo sapiens 40-47 34884968-4 2021 We observed that 5-CQA improved OA-induced intracellular lipid accumulation by downregulating sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FASN) expression, which regulates the fatty acid synthesis, as well as SREBP2 and HMG-CoA reductases (HMG-CoR) expressions, which regulate cholesterol synthesis. Chlorogenic acid 17-22 sterol regulatory element binding transcription factor 1 Homo sapiens 94-137 34961411-5 2021 The molecules 5-O-Feruloyl-quinic acid, 3-Caffeoyl-quinic acid, 5-O-Coumaroyl-D-quinic acid, Epicatechin and Catechin showed promising binding affinity with SARS-CoV-2 Main protease (MPro; PDB ID: 6LU7; responsible for viral replication) and Human Angiotensin Converting Enzyme-2 (ACE2; PDB ID: 1R4L; mediate viral entry in the host). Chlorogenic acid 40-62 NEWENTRY Severe acute respiratory syndrome-related coronavirus 183-187 34884968-8 2021 Our results suggest that 5-CQA alleviates lipid accumulation by downregulating miR-34a, leading to activation of the SIRT1/AMPK pathway. Chlorogenic acid 25-30 microRNA 34a Homo sapiens 79-86 34884968-4 2021 We observed that 5-CQA improved OA-induced intracellular lipid accumulation by downregulating sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FASN) expression, which regulates the fatty acid synthesis, as well as SREBP2 and HMG-CoA reductases (HMG-CoR) expressions, which regulate cholesterol synthesis. Chlorogenic acid 17-22 sterol regulatory element binding transcription factor 1 Homo sapiens 139-145 34884968-4 2021 We observed that 5-CQA improved OA-induced intracellular lipid accumulation by downregulating sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FASN) expression, which regulates the fatty acid synthesis, as well as SREBP2 and HMG-CoA reductases (HMG-CoR) expressions, which regulate cholesterol synthesis. Chlorogenic acid 17-22 fatty acid synthase Homo sapiens 151-170 34884968-8 2021 Our results suggest that 5-CQA alleviates lipid accumulation by downregulating miR-34a, leading to activation of the SIRT1/AMPK pathway. Chlorogenic acid 25-30 sirtuin 1 Homo sapiens 117-122 34884968-4 2021 We observed that 5-CQA improved OA-induced intracellular lipid accumulation by downregulating sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FASN) expression, which regulates the fatty acid synthesis, as well as SREBP2 and HMG-CoA reductases (HMG-CoR) expressions, which regulate cholesterol synthesis. Chlorogenic acid 17-22 fatty acid synthase Homo sapiens 172-176 34884968-4 2021 We observed that 5-CQA improved OA-induced intracellular lipid accumulation by downregulating sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FASN) expression, which regulates the fatty acid synthesis, as well as SREBP2 and HMG-CoA reductases (HMG-CoR) expressions, which regulate cholesterol synthesis. Chlorogenic acid 17-22 sterol regulatory element binding transcription factor 2 Homo sapiens 243-249 34884968-8 2021 Our results suggest that 5-CQA alleviates lipid accumulation by downregulating miR-34a, leading to activation of the SIRT1/AMPK pathway. Chlorogenic acid 25-30 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 123-127 34858550-12 2021 We used high-performance liquid chromatography analyses to identify tricin and chlorogenic acid as the respective components of HVE and CZE that inhibit prolactin secretion. Chlorogenic acid 79-95 prolactin Mus musculus 153-162 34736132-2 2021 Chlorogenic acid (1) has been shown to delay intestinal glucose absorption by inhibiting the activity of alpha-glucosidase (alpha-Glu) and alpha-amylase (alpha-Amy). Chlorogenic acid 0-16 sucrase-isomaltase Homo sapiens 105-122 34515617-0 2021 Combination immunotherapy of chlorogenic acid liposomes modified with sialic acid and PD-1 blockers effectively enhances the anti-tumor immune response and therapeutic effects. Chlorogenic acid 29-45 programmed cell death 1 Mus musculus 86-90 34943017-0 2021 Chlorogenic Acid Attenuates Oxidative Stress-Induced Intestinal Epithelium Injury by Co-Regulating the PI3K/Akt and IkappaBalpha/NF-kappaB Signaling. Chlorogenic acid 0-16 AKT serine/threonine kinase 1 Sus scrofa 108-111 34943017-0 2021 Chlorogenic Acid Attenuates Oxidative Stress-Induced Intestinal Epithelium Injury by Co-Regulating the PI3K/Akt and IkappaBalpha/NF-kappaB Signaling. Chlorogenic acid 0-16 NFKB inhibitor alpha Sus scrofa 116-128 34216581-0 2021 Beneficial effects of chlorogenic acid treatment on neuroinflammation after deep hypothermic circulatory arrest may be mediated through CYLD/NF-kappaB signaling. Chlorogenic acid 22-38 CYLD lysine 63 deubiquitinase Homo sapiens 136-140 34836410-5 2021 CGA administration (40 and 80 mg/kg, 8 weeks) to ethanol-fed group reduced the liver expression levels of Cyp2e1 and iNos, whereas it markedly enhanced the expression of Sod, Nrf2, and Ho-1. Chlorogenic acid 0-3 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 106-112 34836410-5 2021 CGA administration (40 and 80 mg/kg, 8 weeks) to ethanol-fed group reduced the liver expression levels of Cyp2e1 and iNos, whereas it markedly enhanced the expression of Sod, Nrf2, and Ho-1. Chlorogenic acid 0-3 nitric oxide synthase 2 Rattus norvegicus 117-121 34836410-5 2021 CGA administration (40 and 80 mg/kg, 8 weeks) to ethanol-fed group reduced the liver expression levels of Cyp2e1 and iNos, whereas it markedly enhanced the expression of Sod, Nrf2, and Ho-1. Chlorogenic acid 0-3 NFE2 like bZIP transcription factor 2 Rattus norvegicus 175-179 34836410-5 2021 CGA administration (40 and 80 mg/kg, 8 weeks) to ethanol-fed group reduced the liver expression levels of Cyp2e1 and iNos, whereas it markedly enhanced the expression of Sod, Nrf2, and Ho-1. Chlorogenic acid 0-3 heme oxygenase 1 Rattus norvegicus 185-189 34832958-0 2021 Inhibitory Effect of Chlorogenic Acid Analogues Comprising Pyridine and Pyrimidine on alpha-MSH-Stimulated Melanogenesis and Stability of Acyl Analogues in Methanol. Chlorogenic acid 21-37 STAM binding protein Mus musculus 86-95 34795590-5 2021 Results: The obtained results show that the availability of chlorogenic acid, vanillin, and salicylic acid levels in CPE is more favorable for enhancing cell growth, nuclear integrity, and mitochondrial efficiency which is confirmed by propidium iodide staining and JC-1 staining. Chlorogenic acid 60-76 carboxypeptidase E Homo sapiens 117-120 34383255-3 2021 The objective of the study was to examine the potential role of chlorogenic acid (CGA), a polyphenol known for anti-inflammatory effect, in the treatment of experimental AP in mice. Chlorogenic acid 64-80 LIM homeobox protein 2 Mus musculus 170-172 34383255-3 2021 The objective of the study was to examine the potential role of chlorogenic acid (CGA), a polyphenol known for anti-inflammatory effect, in the treatment of experimental AP in mice. Chlorogenic acid 82-85 LIM homeobox protein 2 Mus musculus 170-172 34554395-7 2021 The results of molecular docking studies confirmed that the phytocompound (ligand) luteolin 7-O-glucoside (IHP15) showed the highest binding affinity towards receptor HER2 (PDB ID: 3PP0) with docking score and Glide g score (G-Score) of - 13.272, while chlorogenic acid (IHP12) showed the highest binding affinity towards receptor VEGFR2 (PDB ID: 4AGC) with docking score and Glide g score (G-Score) of - 10.673. Chlorogenic acid 253-269 kinase insert domain receptor Homo sapiens 331-337 34845409-0 2021 Chlorogenic Acids Inhibit Adipogenesis: Implications of Wnt/beta-Catenin Signaling Pathway. Chlorogenic acid 0-17 wingless-type MMTV integration site family, member 10B Mus musculus 56-59 34845409-0 2021 Chlorogenic Acids Inhibit Adipogenesis: Implications of Wnt/beta-Catenin Signaling Pathway. Chlorogenic acid 0-17 catenin (cadherin associated protein), beta 1 Mus musculus 60-72 34473137-0 2021 Chlorogenic acid ameliorates Klebsiella pneumoniae-induced pneumonia in immunosuppressed mice via inhibiting the activation of NLRP3 inflammasomes. Chlorogenic acid 0-16 NLR family, pyrin domain containing 3 Mus musculus 127-132 34466154-0 2021 Gold nanoparticles enhance microRNA 31 detection in colon cancer cells after inhibition with chlorogenic acid. Chlorogenic acid 93-109 microRNA 31 Homo sapiens 27-38 34466154-1 2021 In the present study, the inhibitory effect of chlorogenic acid (CGA), a phenolic compound with potential antitumor effects, on circulating microRNA 31 (miR-31), was evaluated in RKO colon cancer cells. Chlorogenic acid 47-63 microRNA 31 Homo sapiens 140-151 34466154-1 2021 In the present study, the inhibitory effect of chlorogenic acid (CGA), a phenolic compound with potential antitumor effects, on circulating microRNA 31 (miR-31), was evaluated in RKO colon cancer cells. Chlorogenic acid 47-63 microRNA 31 Homo sapiens 153-159 34554395-10 2021 The present study has confirmed luteolin 7-O-glucoside (IHP15) and chlorogenic acid (IHP12) as potential tyrosine kinase inhibitors (TKIs) which were found to inhibit RTKs-HER2 and VEGFR2 receptor proteins, and thus paving the way for development of alternative potential TKIs (drug molecules) for treatment of HER2- and VEGFR2-positive breast and stomach cancer. Chlorogenic acid 67-83 erb-b2 receptor tyrosine kinase 2 Homo sapiens 172-176 34554395-10 2021 The present study has confirmed luteolin 7-O-glucoside (IHP15) and chlorogenic acid (IHP12) as potential tyrosine kinase inhibitors (TKIs) which were found to inhibit RTKs-HER2 and VEGFR2 receptor proteins, and thus paving the way for development of alternative potential TKIs (drug molecules) for treatment of HER2- and VEGFR2-positive breast and stomach cancer. Chlorogenic acid 67-83 kinase insert domain receptor Homo sapiens 181-187 34216581-0 2021 Beneficial effects of chlorogenic acid treatment on neuroinflammation after deep hypothermic circulatory arrest may be mediated through CYLD/NF-kappaB signaling. Chlorogenic acid 22-38 nuclear factor kappa B subunit 1 Homo sapiens 141-150 34465793-8 2021 Furthermore, our screening of a natural compound library identifies chlorogenic acid as a potent inhibitor for IBSP-receptor binding to suppress bone metastasis of ER+ tumor, suggesting its preventive use for bone recurrence in ER+ patients. Chlorogenic acid 68-84 integrin binding sialoprotein Homo sapiens 111-115 34575098-0 2021 Hesperidin and Chlorogenic Acid Synergistically Inhibit the Growth of Breast Cancer Cells via Estrogen Receptor/Mitochondrial Pathway. Chlorogenic acid 15-31 estrogen receptor 1 Homo sapiens 94-111 34575098-7 2021 We demonstrated that the expression of CYC1, TFAM, ATP5PB, mtATP6, mtDNA, and NRF-1 were decreased upon 12 h treatment, and subsequent ATP production was also significantly decreased at 24 h. These results identified a synergistic effect induced by combinational treatment with hesperidin and chlorogenic acid, which can regulate mitochondria and ATP production through the estrogen receptor pathway in MCF-7 cells. Chlorogenic acid 293-309 cytochrome c1 Homo sapiens 39-43 34575098-7 2021 We demonstrated that the expression of CYC1, TFAM, ATP5PB, mtATP6, mtDNA, and NRF-1 were decreased upon 12 h treatment, and subsequent ATP production was also significantly decreased at 24 h. These results identified a synergistic effect induced by combinational treatment with hesperidin and chlorogenic acid, which can regulate mitochondria and ATP production through the estrogen receptor pathway in MCF-7 cells. Chlorogenic acid 293-309 transcription factor A, mitochondrial Homo sapiens 45-49 34575098-7 2021 We demonstrated that the expression of CYC1, TFAM, ATP5PB, mtATP6, mtDNA, and NRF-1 were decreased upon 12 h treatment, and subsequent ATP production was also significantly decreased at 24 h. These results identified a synergistic effect induced by combinational treatment with hesperidin and chlorogenic acid, which can regulate mitochondria and ATP production through the estrogen receptor pathway in MCF-7 cells. Chlorogenic acid 293-309 mitochondrially encoded ATP synthase 6 Homo sapiens 59-65 34575098-7 2021 We demonstrated that the expression of CYC1, TFAM, ATP5PB, mtATP6, mtDNA, and NRF-1 were decreased upon 12 h treatment, and subsequent ATP production was also significantly decreased at 24 h. These results identified a synergistic effect induced by combinational treatment with hesperidin and chlorogenic acid, which can regulate mitochondria and ATP production through the estrogen receptor pathway in MCF-7 cells. Chlorogenic acid 293-309 nuclear respiratory factor 1 Homo sapiens 78-83 34575098-7 2021 We demonstrated that the expression of CYC1, TFAM, ATP5PB, mtATP6, mtDNA, and NRF-1 were decreased upon 12 h treatment, and subsequent ATP production was also significantly decreased at 24 h. These results identified a synergistic effect induced by combinational treatment with hesperidin and chlorogenic acid, which can regulate mitochondria and ATP production through the estrogen receptor pathway in MCF-7 cells. Chlorogenic acid 293-309 estrogen receptor 1 Homo sapiens 374-391 34465793-8 2021 Furthermore, our screening of a natural compound library identifies chlorogenic acid as a potent inhibitor for IBSP-receptor binding to suppress bone metastasis of ER+ tumor, suggesting its preventive use for bone recurrence in ER+ patients. Chlorogenic acid 68-84 epiregulin Homo sapiens 164-166 34465793-8 2021 Furthermore, our screening of a natural compound library identifies chlorogenic acid as a potent inhibitor for IBSP-receptor binding to suppress bone metastasis of ER+ tumor, suggesting its preventive use for bone recurrence in ER+ patients. Chlorogenic acid 68-84 epiregulin Homo sapiens 228-230 34098127-2 2021 This study systematically explored the role of high-intensity ultrasound pre-treatment on the binding mechanisms of beta-lactoglobulin (beta-LG) to two common phenolic compounds, i.e., (-)-epigallocatechin-3-gallate (EGCG) and chlorogenic acid (CA) at neutral and acidic pH (pH 7.2 and 2.4). Chlorogenic acid 227-243 beta-lactoglobulin Bos taurus 116-134 34148008-11 2021 Chlorogenic acid also caused significant improvement in body weight, serum HDL-cholesterol, total protein, and albumin levels leading to betterment in atherogenic indices related to diabetes-associated cardiovascular risks. Chlorogenic acid 0-16 albumin Rattus norvegicus 111-118 34174343-14 2021 Caspase-3, caspase-7, and poly ADP-ribose polymerase expression levels were increased in the MCAO damaged cortex, while chlorogenic acid mitigated these increases. Chlorogenic acid 120-136 caspase 3 Rattus norvegicus 0-9 34174343-14 2021 Caspase-3, caspase-7, and poly ADP-ribose polymerase expression levels were increased in the MCAO damaged cortex, while chlorogenic acid mitigated these increases. Chlorogenic acid 120-136 poly (ADP-ribose) polymerase 1 Rattus norvegicus 26-52 34098127-2 2021 This study systematically explored the role of high-intensity ultrasound pre-treatment on the binding mechanisms of beta-lactoglobulin (beta-LG) to two common phenolic compounds, i.e., (-)-epigallocatechin-3-gallate (EGCG) and chlorogenic acid (CA) at neutral and acidic pH (pH 7.2 and 2.4). Chlorogenic acid 227-243 beta-lactoglobulin Bos taurus 136-143 35450661-4 2022 Thereunto, hyaluronic acid modified transfersomes loaded with chlorogenic acid functioned to reverse M2 type into M1 type via CD44 mediated internalization, the nanomedicine was entrapped in Schiff-based crosslinked injectable hydrogel (fabricated with carboxymethyl chitosan and oxidized dextran) whose linkage was labile to the acidic TME for controlled drug release. Chlorogenic acid 62-78 CD44 molecule (Indian blood group) Homo sapiens 126-130 34276380-0 2021 Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1. Chlorogenic acid 0-16 glucagon Mus musculus 65-70 35313270-0 2022 Chlorogenic acid attenuates inflammation in LPS-induced Human gingival fibroblasts via CysLT1R/Nrf2/NLRP3 signaling. Chlorogenic acid 0-16 cysteinyl leukotriene receptor 1 Homo sapiens 87-94 35313270-0 2022 Chlorogenic acid attenuates inflammation in LPS-induced Human gingival fibroblasts via CysLT1R/Nrf2/NLRP3 signaling. Chlorogenic acid 0-16 NFE2 like bZIP transcription factor 2 Homo sapiens 95-99 35313270-0 2022 Chlorogenic acid attenuates inflammation in LPS-induced Human gingival fibroblasts via CysLT1R/Nrf2/NLRP3 signaling. Chlorogenic acid 0-16 NLR family pyrin domain containing 3 Homo sapiens 100-105 35633920-0 2022 Chlorogenic Acid Alleviates the Inflammatory Stress of LPS-Induced BV2 Cell via Interacting with TLR4-Mediated Downstream Pathway. Chlorogenic acid 0-16 toll-like receptor 4 Mus musculus 97-101 35628642-0 2022 Coffee Polyphenol, Chlorogenic Acid, Suppresses Brain Aging and Its Effects Are Enhanced by Milk Fat Globule Membrane Components. Chlorogenic acid 19-35 milk fat globule EGF and factor V/VIII domain containing Mus musculus 92-117 35545727-2 2022 Based on the interactions between chlorogenic acid and the proteins (human serum albumin (HSA), pepsin (Pep), trypsin (Try), fat mass and obesity-associated protein (FTO)), results will provide clues for screening effective inhibitors. Chlorogenic acid 34-50 albumin Homo sapiens 75-88 35545727-2 2022 Based on the interactions between chlorogenic acid and the proteins (human serum albumin (HSA), pepsin (Pep), trypsin (Try), fat mass and obesity-associated protein (FTO)), results will provide clues for screening effective inhibitors. Chlorogenic acid 34-50 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 125-164 35545727-2 2022 Based on the interactions between chlorogenic acid and the proteins (human serum albumin (HSA), pepsin (Pep), trypsin (Try), fat mass and obesity-associated protein (FTO)), results will provide clues for screening effective inhibitors. Chlorogenic acid 34-50 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 166-169 35545727-3 2022 The interaction between chlorogenic acid and the four proteins (HSA, Pep, Try, FTO) was analyzed by the aid of fluorescence quenching, synchronous fluorescence, three-dimensional fluorescence, isothermal titration calorimetry, and molecular docking. Chlorogenic acid 24-40 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 79-82 35633920-8 2022 Chlorogenic acid significantly reduced the levels of TNF-alpha, IL-6, IL-1beta, and IFN-alpha. Chlorogenic acid 0-16 tumor necrosis factor Mus musculus 53-62 35633920-8 2022 Chlorogenic acid significantly reduced the levels of TNF-alpha, IL-6, IL-1beta, and IFN-alpha. Chlorogenic acid 0-16 interleukin 6 Mus musculus 64-68 35633920-8 2022 Chlorogenic acid significantly reduced the levels of TNF-alpha, IL-6, IL-1beta, and IFN-alpha. Chlorogenic acid 0-16 interleukin 1 alpha Mus musculus 70-78 35633920-8 2022 Chlorogenic acid significantly reduced the levels of TNF-alpha, IL-6, IL-1beta, and IFN-alpha. Chlorogenic acid 0-16 interferon alpha Mus musculus 84-93 35633920-9 2022 Moreover, the abundances of TLR4, MyD88, TRIF, and NF-kappaB were increased in LPS-induced BV2 cells, while chlorogenic acid could obviously reduce their expressions. Chlorogenic acid 108-124 toll-like receptor 4 Mus musculus 28-32 35633920-9 2022 Moreover, the abundances of TLR4, MyD88, TRIF, and NF-kappaB were increased in LPS-induced BV2 cells, while chlorogenic acid could obviously reduce their expressions. Chlorogenic acid 108-124 myeloid differentiation primary response gene 88 Mus musculus 34-39 35633920-9 2022 Moreover, the abundances of TLR4, MyD88, TRIF, and NF-kappaB were increased in LPS-induced BV2 cells, while chlorogenic acid could obviously reduce their expressions. Chlorogenic acid 108-124 toll-like receptor adaptor molecule 2 Mus musculus 41-45 35633920-10 2022 Conclusion: This study suggests that chlorogenic acid can improve the inflammatory stress of LPS-induced BV2 cell via interacting with the TLR4-mediated downstream pathway, which is a potential drug for neuroinflammation treatment. Chlorogenic acid 37-53 toll-like receptor 4 Mus musculus 139-143 35600782-7 2022 Results: CGA and four ginsenosides, which are bioactive compounds of sHCG, significantly inhibited TNF-alpha/IFN-gamma-induced TARC/CCL17 expression. Chlorogenic acid 9-12 C-C motif chemokine ligand 17 Homo sapiens 127-131 35600782-7 2022 Results: CGA and four ginsenosides, which are bioactive compounds of sHCG, significantly inhibited TNF-alpha/IFN-gamma-induced TARC/CCL17 expression. Chlorogenic acid 9-12 C-C motif chemokine ligand 17 Homo sapiens 132-137 35487926-5 2022 Additionally, inhibition of IL-1beta secretion and TRAP activity were determined for chlorogenic acid, catechin, naringenin and beta-sitosterol. Chlorogenic acid 85-101 interleukin 1 alpha Mus musculus 28-36 35591555-0 2022 Tyrosinase-Based Biosensor-A New Tool for Chlorogenic Acid Detection in Nutraceutical Formulations. Chlorogenic acid 42-58 tyrosinase Homo sapiens 0-10 35575783-9 2022 Concerning the analysis through docking, the complexes formed between chlorogenic acid and the targets Thymidylate Kinase, CYP51, 1Yeast Cytochrome BC1 Complex e Exo-B-(1,3)-glucanase demonstrated more favourable binding energy. Chlorogenic acid 70-86 sterol 14-demethylase Saccharomyces cerevisiae S288C 123-128 35591555-1 2022 The purpose of our research was to develop a new enzymatic biosensor, GPH-MnPc-Tyr/SPE, using as a support screen-printed carbon electrode (SPE) modified with graphene, manganese phthalocyanine, and tyrosinase, with the aim of developing sensitive detection of chlorogenic acid (CGA). Chlorogenic acid 261-277 gephyrin Homo sapiens 70-73 35487926-5 2022 Additionally, inhibition of IL-1beta secretion and TRAP activity were determined for chlorogenic acid, catechin, naringenin and beta-sitosterol. Chlorogenic acid 85-101 acid phosphatase 5, tartrate resistant Mus musculus 51-55 35487926-10 2022 IL-6 secretion was significantly inhibited by P. africana methanolic extract (p < 0.0001) and beta-sitosterol (p < 0.0001) and further, chlorogenic acid and naringenin remarkably inhibited IL-1beta production. Chlorogenic acid 136-152 interleukin 1 alpha Mus musculus 189-197 35492257-2 2022 In this study, cinnamaldehyde essential oil (CEO) and chlorogenic acid (CA) were co-encapsulated in chitosan (CS) nanoparticles based Pickering emulsion. Chlorogenic acid 54-70 citrate synthase Homo sapiens 110-112 35353100-0 2022 Chlorogenic acid improves the intestinal barrier by relieving endoplasmic reticulum stress and inhibiting ROCK/MLCK signaling pathways. Chlorogenic acid 0-16 myosin light chain kinase Homo sapiens 111-115 35458238-4 2022 Chlorogenic acid increased the activity of mitochondrial enzymes, including citrate synthase, isocitrate dehydrogenase, and malate dehydrogenase (MDH), which are involved in the tricarboxylic acid (TCA) cycle. Chlorogenic acid 0-16 malic enzyme 1 Homo sapiens 124-144 35458238-4 2022 Chlorogenic acid increased the activity of mitochondrial enzymes, including citrate synthase, isocitrate dehydrogenase, and malate dehydrogenase (MDH), which are involved in the tricarboxylic acid (TCA) cycle. Chlorogenic acid 0-16 citrate synthase Homo sapiens 76-92 35458238-4 2022 Chlorogenic acid increased the activity of mitochondrial enzymes, including citrate synthase, isocitrate dehydrogenase, and malate dehydrogenase (MDH), which are involved in the tricarboxylic acid (TCA) cycle. Chlorogenic acid 0-16 malic enzyme 1 Homo sapiens 146-149 35380825-0 2022 Chlorogenic Acid Alleviates Chronic Stress-Induced Duodenal Ferroptosis via the Inhibition of the IL-6/JAK2/STAT3 Signaling Pathway in Rats. Chlorogenic acid 0-16 interleukin 6 Rattus norvegicus 98-102 35380825-0 2022 Chlorogenic Acid Alleviates Chronic Stress-Induced Duodenal Ferroptosis via the Inhibition of the IL-6/JAK2/STAT3 Signaling Pathway in Rats. Chlorogenic acid 0-16 Janus kinase 2 Rattus norvegicus 103-107 35380825-0 2022 Chlorogenic Acid Alleviates Chronic Stress-Induced Duodenal Ferroptosis via the Inhibition of the IL-6/JAK2/STAT3 Signaling Pathway in Rats. Chlorogenic acid 0-16 signal transducer and activator of transcription 3 Rattus norvegicus 108-113 35189090-6 2022 According to the in-depth studies, the abnormal activation of HIF-1alpha/glucose transporters/glycolysis pathway of 5-CQA could be a key molecular mechanism leading to drug resistance of HCC cells. Chlorogenic acid 116-121 hypoxia inducible factor 1 subunit alpha Homo sapiens 62-72 35437426-0 2022 Chlorogenic Acid as a Positive Regulator in LPS-PG-Induced Inflammation via TLR4/MyD88-Mediated NF-kappaB and PI3K/MAPK Signaling Cascades in Human Gingival Fibroblasts. Chlorogenic acid 0-16 MYD88 innate immune signal transduction adaptor Homo sapiens 81-86 35437426-0 2022 Chlorogenic Acid as a Positive Regulator in LPS-PG-Induced Inflammation via TLR4/MyD88-Mediated NF-kappaB and PI3K/MAPK Signaling Cascades in Human Gingival Fibroblasts. Chlorogenic acid 0-16 nuclear factor kappa B subunit 1 Homo sapiens 96-105 35437426-7 2022 Furthermore, LPS-PG-induced phosphorylation of extracellular regulated kinase (ERK) and Akt was abolished by CGA treatment, while c-Jun N-terminal kinase (JNK) and p38 did not have any effect. Chlorogenic acid 109-112 mitogen-activated protein kinase 1 Homo sapiens 47-77 35437426-7 2022 Furthermore, LPS-PG-induced phosphorylation of extracellular regulated kinase (ERK) and Akt was abolished by CGA treatment, while c-Jun N-terminal kinase (JNK) and p38 did not have any effect. Chlorogenic acid 109-112 mitogen-activated protein kinase 1 Homo sapiens 79-82 35437426-7 2022 Furthermore, LPS-PG-induced phosphorylation of extracellular regulated kinase (ERK) and Akt was abolished by CGA treatment, while c-Jun N-terminal kinase (JNK) and p38 did not have any effect. Chlorogenic acid 109-112 AKT serine/threonine kinase 1 Homo sapiens 88-91 35189090-7 2022 Thus, this study found that glucose starvation, glucose analogue 2-DG, hexokinase inhibitor bromopyruvic acid and PKM2 inhibitor compound 3k inhibited HCC cell proliferation in synergy with 5-CQA. Chlorogenic acid 190-195 hexokinase 1 Homo sapiens 71-81 35189090-7 2022 Thus, this study found that glucose starvation, glucose analogue 2-DG, hexokinase inhibitor bromopyruvic acid and PKM2 inhibitor compound 3k inhibited HCC cell proliferation in synergy with 5-CQA. Chlorogenic acid 190-195 pyruvate kinase M1/2 Homo sapiens 114-118 35189090-8 2022 Furthermore, though the 5-CQA derivatives methyl chlorogenate (MCGA) and 3,5-dicaffeoylquinic acid (3,5-diCQA) exhibited more potent antiproliferation activity in HCC cells than 5-CQA, they also up-regulated the expression of GLUT1/3, whereas they had no effect on hepatocytes. Chlorogenic acid 24-29 solute carrier family 2 member 1 Homo sapiens 226-233 35545320-17 2022 CONCLUSIONS: Chlorogenic acid may increase the level of miR-223, target the inhibition of NLRP3 expression, reduce LPS-induced inflammatory response in ALI mice, and alleviate pathological damage of lung tissues. Chlorogenic acid 13-29 microRNA 223 Mus musculus 56-63 35409218-0 2022 The Apoptotic Effect of Caffeic or Chlorogenic Acid on the C32 Cells That Have Simultaneously Been Exposed to a Static Magnetic Field. Chlorogenic acid 35-51 chemokine like factor Homo sapiens 59-62 35409218-3 2022 Hence, the aim of this study was to evaluate the anti-tumor effect of caffeic or chlorogenic acid in combination with a moderate-strength static magnetic field on C32 melanoma cells by assessing the effect of both factors on the apoptotic process. Chlorogenic acid 81-97 chemokine like factor Homo sapiens 163-166 35545320-0 2022 Mechanism of chlorogenic acid reducing lipopolysaccharide-induced acute lung injury in mice by regulating miR-223/NLRP3 axis. Chlorogenic acid 13-29 microRNA 223 Mus musculus 106-113 35545320-0 2022 Mechanism of chlorogenic acid reducing lipopolysaccharide-induced acute lung injury in mice by regulating miR-223/NLRP3 axis. Chlorogenic acid 13-29 NLR family, pyrin domain containing 3 Mus musculus 114-119 35545320-17 2022 CONCLUSIONS: Chlorogenic acid may increase the level of miR-223, target the inhibition of NLRP3 expression, reduce LPS-induced inflammatory response in ALI mice, and alleviate pathological damage of lung tissues. Chlorogenic acid 13-29 NLR family, pyrin domain containing 3 Mus musculus 90-95 35545320-3 2022 This study aims to investigate whether chlorogenic acid attenuates lipopolysaccharide (LPS)-induced ALI in mice by regulating the microRNA-223 (miR-223)/nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) axis. Chlorogenic acid 39-55 microRNA 223 Mus musculus 130-142 35545320-3 2022 This study aims to investigate whether chlorogenic acid attenuates lipopolysaccharide (LPS)-induced ALI in mice by regulating the microRNA-223 (miR-223)/nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) axis. Chlorogenic acid 39-55 microRNA 223 Mus musculus 144-151 35108588-15 2022 This study confirmed that chlorogenic acid exerts an anti-oxidative effect and elucidated anti-inflammatory effect through regulating NF-kappaB, IL-1beta, and TNF-alpha on cerebral ischemia. Chlorogenic acid 26-42 tumor necrosis factor Rattus norvegicus 159-168 35545320-3 2022 This study aims to investigate whether chlorogenic acid attenuates lipopolysaccharide (LPS)-induced ALI in mice by regulating the microRNA-223 (miR-223)/nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) axis. Chlorogenic acid 39-55 NLR family, pyrin domain containing 3 Mus musculus 220-225 35108588-15 2022 This study confirmed that chlorogenic acid exerts an anti-oxidative effect and elucidated anti-inflammatory effect through regulating NF-kappaB, IL-1beta, and TNF-alpha on cerebral ischemia. Chlorogenic acid 26-42 interleukin 1 alpha Rattus norvegicus 145-153 35330101-6 2022 Murine double minute 2 (MDM2) was found to interact well with chlorogenic acid and oleuropein, two compounds from coffee and olive oils, respectively. Chlorogenic acid 62-78 transformed mouse 3T3 cell double minute 2 Mus musculus 0-22 35133045-0 2022 Chlorogenic acid improves diabetic retinopathy by alleviating blood-retinal-barrier dysfunction via inducing Nrf2 activation. Chlorogenic acid 0-16 nuclear factor, erythroid derived 2, like 2 Mus musculus 109-113 35289676-4 2022 Chlorogenic acid (CGA), curcumin (CUR), epigallocatechin gallate (EGCG), and resveratrol (RSV) can act as antioxidants that activate AMP-activated protein kinase (AMPK) to downregulate ROS, and as prooxidants to generate ROS, leading to the downregulation of NF-kappaB. Chlorogenic acid 0-16 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 133-161 35289676-4 2022 Chlorogenic acid (CGA), curcumin (CUR), epigallocatechin gallate (EGCG), and resveratrol (RSV) can act as antioxidants that activate AMP-activated protein kinase (AMPK) to downregulate ROS, and as prooxidants to generate ROS, leading to the downregulation of NF-kappaB. Chlorogenic acid 0-16 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 163-167 35289676-4 2022 Chlorogenic acid (CGA), curcumin (CUR), epigallocatechin gallate (EGCG), and resveratrol (RSV) can act as antioxidants that activate AMP-activated protein kinase (AMPK) to downregulate ROS, and as prooxidants to generate ROS, leading to the downregulation of NF-kappaB. Chlorogenic acid 0-16 nuclear factor kappa B subunit 1 Homo sapiens 259-268 35007929-6 2022 Compared to the control group, the protein level of COX2 was significantly upregulated in the chlorogenic acid, CpG-DNA, and chicken IgG groups. Chlorogenic acid 94-110 mitochondrially encoded cytochrome c oxidase II Homo sapiens 52-56 35330101-6 2022 Murine double minute 2 (MDM2) was found to interact well with chlorogenic acid and oleuropein, two compounds from coffee and olive oils, respectively. Chlorogenic acid 62-78 transformed mouse 3T3 cell double minute 2 Mus musculus 24-28 35209219-4 2022 Subsequently, a dietary polyphenol, chlorogenic acid, was loaded into the mesopores of MSN (denoted as MSN-His6@CGA), realizing the potential of its anti-inflammatory properties. Chlorogenic acid 36-52 moesin Homo sapiens 87-90 35257010-0 2022 Chlorogenic Acid Inhibits Lipid Deposition by Regulating the Enterohepatic FXR-FGF15 Pathway. Chlorogenic acid 0-16 nuclear receptor subfamily 1, group H, member 4 Mus musculus 75-78 35257010-0 2022 Chlorogenic Acid Inhibits Lipid Deposition by Regulating the Enterohepatic FXR-FGF15 Pathway. Chlorogenic acid 0-16 fibroblast growth factor 15 Mus musculus 79-84 35201648-0 2022 miR-23b/TAB3/NF-kappaB/p53 axis is involved in hippocampus injury induced by cerebral ischemia-reperfusion in rats: The protective effect of chlorogenic acid. Chlorogenic acid 141-157 microRNA 23b Rattus norvegicus 0-7 35201648-0 2022 miR-23b/TAB3/NF-kappaB/p53 axis is involved in hippocampus injury induced by cerebral ischemia-reperfusion in rats: The protective effect of chlorogenic acid. Chlorogenic acid 141-157 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 23-26 35201648-3 2022 The aim of this study is to explore the effect of cerebral I/R on miR-23a/TGF-beta-activated kinase 1 binding protein 3 (TAB3)/nuclear factor kappa B (NF-kappaB)/p53 axis in rat hippocampus alone and in combination with chlorogenic acid (CGA). Chlorogenic acid 220-236 microRNA 23a Rattus norvegicus 66-119 35201648-3 2022 The aim of this study is to explore the effect of cerebral I/R on miR-23a/TGF-beta-activated kinase 1 binding protein 3 (TAB3)/nuclear factor kappa B (NF-kappaB)/p53 axis in rat hippocampus alone and in combination with chlorogenic acid (CGA). Chlorogenic acid 220-236 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 162-165 35209219-4 2022 Subsequently, a dietary polyphenol, chlorogenic acid, was loaded into the mesopores of MSN (denoted as MSN-His6@CGA), realizing the potential of its anti-inflammatory properties. Chlorogenic acid 36-52 moesin Homo sapiens 103-115 35164229-7 2022 Furthermore, chlorogenic acid, tyramine derivatives, and the mixture of the six identified major compounds significantly decreased IL-6 secretion by LPS-activated J774 cells. Chlorogenic acid 13-29 interleukin 6 Mus musculus 131-135 35208196-5 2022 Mitogen-activated protein kinase (MAPK) 3 and protein kinase B (AKT) 1 were suggested as key targets regulated primarily by chlorogenic acid (CA) and swertiamarin (SWE). Chlorogenic acid 124-140 mitogen-activated protein kinase 3 Homo sapiens 0-41 35208196-5 2022 Mitogen-activated protein kinase (MAPK) 3 and protein kinase B (AKT) 1 were suggested as key targets regulated primarily by chlorogenic acid (CA) and swertiamarin (SWE). Chlorogenic acid 124-140 AKT serine/threonine kinase 1 Homo sapiens 46-70 35161257-7 2022 The inhibition of alpha-glucosidase was strongly positively correlated with the total and condensed tannins, procyanidin dimers and procyanidin tetramer, and was very strongly correlated with chlorogenic acid. Chlorogenic acid 192-208 sucrase-isomaltase Homo sapiens 18-35 3139287-3 1988 In an additional study, the topical application of 10 mumol of curcumin, chlorogenic acid, caffeic acid, or ferulic acid inhibited by 91, 25, 42, or 46%, respectively, the induction of ornithine decarboxylase activity by 5 nmol of TPA. Chlorogenic acid 73-89 ornithine decarboxylase, structural 1 Mus musculus 185-208 24271680-3 1989 When the tomato fruitwormHeliothis zea or the beet army-wormSpodoptera exigua feed on tomato foliage, a substantial amount of the ingested chlorogenic acid is oxidized to chlorogenoquinone by PPO in the insect gut. Chlorogenic acid 139-155 polyphenol oxidase B, chloroplastic Solanum lycopersicum 192-195 16658575-4 1973 In addition, the activity of phenylalanine ammonia-lyase and polyphenol-oxidase was higher in the green lamina than in the yellow tissue, which coincided with quantitative distribution of chlorogenic acid. Chlorogenic acid 188-204 phenylalanine ammonia-lyase Nicotiana tabacum 29-56 24302205-1 1981 During the first 24 h of in vitro incubation of excised potato tuber (Solanum tuberosum L.) discs, the appearance of phenylalanine ammonia-lyase (PAL; EC 3.4.1.5) and the accumulation of chlorogenic acid are both stimulated by infection with Phytophthora infestans (Mont.) Chlorogenic acid 187-203 phenylalanine ammonia-lyase Solanum tuberosum 146-149 24302205-4 1981 In the infected but not the control tissue, the level of chlorogenic acid subsequently fell to about to about 20% of its maximum after 50 h. The time courses of increases in cinnamic acid 4-hydroxylase (CA4H; EC 1.14.13.11; 0-60 h) and of caffeic acid acid o-methyltransferase (COMT; EC 2.1.1.42; 0-160 h) are not altered by fungal infection. Chlorogenic acid 57-73 trans-cinnamate 4-monooxygenase Solanum tuberosum 203-207 24302205-7 1981 The experiments provide further evidence that PAL is the rate limiting step of chlorogenic acid biosynthesis in potato tuber discs. Chlorogenic acid 79-95 phenylalanine ammonia-lyase Solanum tuberosum 46-49 16658575-10 1973 Results suggest that in addition to phenylalanine ammonia-lyase as a key enzyme regulating chlorogenic acid biosynthesis, an alternative pathway involving the conversion of phenylpyruvate to cinnamate may be functional in tobacco leaves. Chlorogenic acid 91-107 phenylalanine ammonia-lyase Nicotiana tabacum 36-63 4980717-3 1969 The reactions between chlorogenoquinone, the o-quinone formed during the oxidation of chlorogenic acid, and bovine serum albumin depend on the ratio of reactants. Chlorogenic acid 86-102 albumin Homo sapiens 115-128 33711382-0 2021 Chlorogenic Acid retards cartilaginous endplate degeneration and ameliorates intervertebral disc degeneration via suppressing NF-kappaB signaling. Chlorogenic acid 0-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 126-135 16657046-10 1969 Of interest is that the same 10 peroxidase isozyme bands also exhibited polyphenol oxidase activities when treated with 3,4-dihydroxyphenylalanine or chlorogenic acid. Chlorogenic acid 150-166 lignin-forming anionic peroxidase-like Nicotiana tabacum 32-42 33258205-0 2021 Chlorogenic acid depresses cellular bioenergetics to suppress pancreatic carcinoma through modulating c-Myc-TFR1 axis. Chlorogenic acid 0-16 MYC proto-oncogene, bHLH transcription factor Homo sapiens 102-107 33838673-9 2021 Except for the lower level of total cholesterol in caffeine group (p = 0.04), and higher level of insulin in chlorogenic acid plus caffeine group (p = 0.01) compared with placebo, there were no significant differences among the treatment groups. Chlorogenic acid 109-125 insulin Homo sapiens 98-105 34017254-0 2021 Geniposide and Chlorogenic Acid Combination Improves Non-Alcoholic Fatty Liver Disease Involving the Potent Suppression of Elevated Hepatic SCD-1. Chlorogenic acid 15-31 stearoyl-Coenzyme A desaturase 1 Mus musculus 140-145 33734387-0 2021 Chlorogenic acid ameliorates mice clinical endometritis by activating Keap1/Nrf2 and inhibiting NFkappaB signalling pathway. Chlorogenic acid 0-16 kelch-like ECH-associated protein 1 Mus musculus 70-75 33734387-0 2021 Chlorogenic acid ameliorates mice clinical endometritis by activating Keap1/Nrf2 and inhibiting NFkappaB signalling pathway. Chlorogenic acid 0-16 nuclear factor, erythroid derived 2, like 2 Mus musculus 76-80 33734387-0 2021 Chlorogenic acid ameliorates mice clinical endometritis by activating Keap1/Nrf2 and inhibiting NFkappaB signalling pathway. Chlorogenic acid 0-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 96-104 33258205-0 2021 Chlorogenic acid depresses cellular bioenergetics to suppress pancreatic carcinoma through modulating c-Myc-TFR1 axis. Chlorogenic acid 0-16 transferrin receptor Homo sapiens 108-112 32916406-3 2021 In the present study, we identified 44 flavonols and chlorogenic acid in 30 samples of Highbush and Rabbiteye blueberry, using HPLC-DAD-ESI-MSn. Chlorogenic acid 53-69 moesin Homo sapiens 140-143 33639350-8 2021 Moreover, pretreatment with baicalein and chlorogenic acid significantly inhibited NF-kappaB activation, and this inhibited the subsequent production of the proinflammatory cytokines TNF-alpha and IL-1beta in the context of IBDV infection. Chlorogenic acid 42-58 nuclear factor kappa B subunit 1 Homo sapiens 83-92 33639350-8 2021 Moreover, pretreatment with baicalein and chlorogenic acid significantly inhibited NF-kappaB activation, and this inhibited the subsequent production of the proinflammatory cytokines TNF-alpha and IL-1beta in the context of IBDV infection. Chlorogenic acid 42-58 tumor necrosis factor Homo sapiens 183-192 33639350-8 2021 Moreover, pretreatment with baicalein and chlorogenic acid significantly inhibited NF-kappaB activation, and this inhibited the subsequent production of the proinflammatory cytokines TNF-alpha and IL-1beta in the context of IBDV infection. Chlorogenic acid 42-58 interleukin 1 alpha Homo sapiens 197-205 33833498-0 2021 Chlorogenic Acid Inhibits Human Glioma U373 Cell Progression via Regulating the SRC/MAPKs Signal Pathway: Based on Network Pharmacology Analysis. Chlorogenic acid 0-16 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 80-83 33687206-1 2021 Chlorogenic acid (CGA) and guaiacyl/syringyl (G/S) lignin formation involves hydroxycinnamoyl ester intermediacy, the latter formed via hydroxycinnamoyl CoA:shikimate hydroxycinnamoyl transferase (HCT) and hydroxycinnamoyl CoA:quinate hydroxycinnamoyl transferase (HQT) activities. Chlorogenic acid 0-16 shikimate O-hydroxycinnamoyltransferase Nicotiana tabacum 197-200 33494608-0 2021 Protection Mechanisms Underlying Oral Administration of Chlorogenic Acid against Cadmium-Induced Hepatorenal Injury Related to Regulating Intestinal Flora Balance. Chlorogenic acid 56-72 cathepsin D Mus musculus 81-88 33715179-8 2021 Eventually, the established method has been applied to screen potential alpha-glucosidase inhibitors from an extract of Lycium barbarum and the peak area of rutin, taxifolin, quercetin and chlorogenic acid in L. barbarum samples changed before and after the enzymatic reaction, confirming that these four compounds had potential inhibitory activities, which was consistent with the literature data. Chlorogenic acid 189-205 sucrase-isomaltase Homo sapiens 72-89 33491243-10 2021 Additionally, CGA increased anti-inflammatory cytokine -interleukin-10-, suppressed caspase-3 activity, and reduced pathological lesions in the examined organs of rats co-treated with CGA and TAM. Chlorogenic acid 14-17 interleukin 10 Rattus norvegicus 56-70 33558562-7 2021 The encapsulation of chlorogenic acid led to a similar CD order and scores, although constants were higher for alpha-CD, beta-CD and M-beta-CD, lower for HP-beta-CD, and negligible for gamma-CD. Chlorogenic acid 21-37 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 111-119 33558562-7 2021 The encapsulation of chlorogenic acid led to a similar CD order and scores, although constants were higher for alpha-CD, beta-CD and M-beta-CD, lower for HP-beta-CD, and negligible for gamma-CD. Chlorogenic acid 21-37 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 121-128 33558562-7 2021 The encapsulation of chlorogenic acid led to a similar CD order and scores, although constants were higher for alpha-CD, beta-CD and M-beta-CD, lower for HP-beta-CD, and negligible for gamma-CD. Chlorogenic acid 21-37 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 135-142 33558562-7 2021 The encapsulation of chlorogenic acid led to a similar CD order and scores, although constants were higher for alpha-CD, beta-CD and M-beta-CD, lower for HP-beta-CD, and negligible for gamma-CD. Chlorogenic acid 21-37 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 135-142 33058431-0 2021 Chlorogenic acid induces 4T1 breast cancer tumor"s apoptosis via p53, Bax, Bcl-2, and caspase-3 signaling pathways in BALB/c mice. Chlorogenic acid 0-16 transformation related protein 53, pseudogene Mus musculus 65-68 33058431-0 2021 Chlorogenic acid induces 4T1 breast cancer tumor"s apoptosis via p53, Bax, Bcl-2, and caspase-3 signaling pathways in BALB/c mice. Chlorogenic acid 0-16 BCL2-associated X protein Mus musculus 70-73 33058431-0 2021 Chlorogenic acid induces 4T1 breast cancer tumor"s apoptosis via p53, Bax, Bcl-2, and caspase-3 signaling pathways in BALB/c mice. Chlorogenic acid 0-16 B cell leukemia/lymphoma 2 Mus musculus 75-80 33058431-0 2021 Chlorogenic acid induces 4T1 breast cancer tumor"s apoptosis via p53, Bax, Bcl-2, and caspase-3 signaling pathways in BALB/c mice. Chlorogenic acid 0-16 caspase 3 Mus musculus 86-95 33491243-10 2021 Additionally, CGA increased anti-inflammatory cytokine -interleukin-10-, suppressed caspase-3 activity, and reduced pathological lesions in the examined organs of rats co-treated with CGA and TAM. Chlorogenic acid 14-17 caspase 3 Rattus norvegicus 84-93 33575061-0 2021 Retracted: Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3beta and APC and Inhibiting Gene beta-Catenin. Chlorogenic acid 44-60 glycogen synthase kinase 3 alpha Homo sapiens 80-89 33416150-0 2021 Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF-kappaB signaling pathway. Chlorogenic acid 0-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 113-122 33416150-3 2021 In the present study, it was reported that chlorogenic acid (CGA), a potent NF-kappaB inhibitor derived from coffee, exerted antitumor activity in breast cancer. Chlorogenic acid 43-59 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 76-85 33575061-0 2021 Retracted: Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3beta and APC and Inhibiting Gene beta-Catenin. Chlorogenic acid 44-60 catenin beta 1 Homo sapiens 118-130 33298336-0 2021 Corrigendum to "Chlorogenic acid attenuates glucotoxicity in H9c2 cells via inhibition of glycation and PKC alpha upregulation and safeguarding innate antioxidant status" [Biomed. Chlorogenic acid 16-32 protein kinase C, alpha Rattus norvegicus 104-113 33503991-7 2021 Moreover, chlorogenic acid isolated from EPX exerted protective effects against blue light-induced cell damage in A2E-laden ARPE-19 cells. Chlorogenic acid 10-26 eosinophil peroxidase Homo sapiens 41-44 33506010-10 2021 Moreover, the TNF-alpha decreased significantly accompanied by the increase of berberine, chlorogenic acid, jatrorrhizine, palmatine, evodin, and evodiamine in serum (negative correlation, p < 0.05). Chlorogenic acid 90-106 tumor necrosis factor Rattus norvegicus 14-23 33326684-9 2021 MET and CGA combination treatment resulted in the polarization of macrophages to the M2 phenotype, reduction of the expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6), and decreasing protein level of NF-kB p65. Chlorogenic acid 8-11 tumor necrosis factor Mus musculus 158-167 33326684-9 2021 MET and CGA combination treatment resulted in the polarization of macrophages to the M2 phenotype, reduction of the expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6), and decreasing protein level of NF-kB p65. Chlorogenic acid 8-11 interleukin 1 alpha Mus musculus 169-177 33326684-9 2021 MET and CGA combination treatment resulted in the polarization of macrophages to the M2 phenotype, reduction of the expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6), and decreasing protein level of NF-kB p65. Chlorogenic acid 8-11 interleukin 6 Mus musculus 182-186 33326684-9 2021 MET and CGA combination treatment resulted in the polarization of macrophages to the M2 phenotype, reduction of the expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6), and decreasing protein level of NF-kB p65. Chlorogenic acid 8-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 227-230 33200558-0 2021 Chlorogenic Acid Alleviates Hyperglycemia-Induced Cardiac Fibrosis through Activation of the NO/cGMP/PKG Pathway in Cardiac Fibroblasts. Chlorogenic acid 0-16 protein kinase cGMP-dependent 1 Homo sapiens 101-104 33472479-0 2021 Dietary chlorogenic acid ameliorates oxidative stress and improves endothelial function in diabetic mice via Nrf2 activation. Chlorogenic acid 8-24 nuclear factor, erythroid derived 2, like 2 Mus musculus 109-113 33472479-5 2021 RESULTS: CGA treatment induced upregulation of Nrf2 in HUVECs in a dose-dependent manner. Chlorogenic acid 9-12 nuclear factor, erythroid derived 2, like 2 Mus musculus 47-51 33426081-6 2020 Results: The active components of ZR-CR-shogaol, daucosterol, ginkgetin, berberine, quercetin, chlorogenic acid, and vanillic acid-exhibited antitumor activities via the MAPK, PI3K-AKT, TNF, FOXO, HIF-1, and VEGF signaling pathways. Chlorogenic acid 95-111 AKT serine/threonine kinase 1 Homo sapiens 181-184 33426081-6 2020 Results: The active components of ZR-CR-shogaol, daucosterol, ginkgetin, berberine, quercetin, chlorogenic acid, and vanillic acid-exhibited antitumor activities via the MAPK, PI3K-AKT, TNF, FOXO, HIF-1, and VEGF signaling pathways. Chlorogenic acid 95-111 tumor necrosis factor Homo sapiens 186-189 33426081-6 2020 Results: The active components of ZR-CR-shogaol, daucosterol, ginkgetin, berberine, quercetin, chlorogenic acid, and vanillic acid-exhibited antitumor activities via the MAPK, PI3K-AKT, TNF, FOXO, HIF-1, and VEGF signaling pathways. Chlorogenic acid 95-111 hypoxia inducible factor 1 subunit alpha Homo sapiens 197-202 33426081-6 2020 Results: The active components of ZR-CR-shogaol, daucosterol, ginkgetin, berberine, quercetin, chlorogenic acid, and vanillic acid-exhibited antitumor activities via the MAPK, PI3K-AKT, TNF, FOXO, HIF-1, and VEGF signaling pathways. Chlorogenic acid 95-111 vascular endothelial growth factor A Homo sapiens 208-212 33443209-5 2020 Overexpressing constitutively active Akt1 in SH-SY5Y cells or culturing cells with chlorogenic acid (a polyphenol found in coffee that activates Akt1) stimulated the CREB-dependent transcriptional activation of the gene encoding the E3 ubiquitin ligase RNF146. Chlorogenic acid 83-99 cAMP responsive element binding protein 1 Homo sapiens 166-170 33443209-5 2020 Overexpressing constitutively active Akt1 in SH-SY5Y cells or culturing cells with chlorogenic acid (a polyphenol found in coffee that activates Akt1) stimulated the CREB-dependent transcriptional activation of the gene encoding the E3 ubiquitin ligase RNF146. Chlorogenic acid 83-99 ring finger protein 146 Homo sapiens 253-259 33443209-5 2020 Overexpressing constitutively active Akt1 in SH-SY5Y cells or culturing cells with chlorogenic acid (a polyphenol found in coffee that activates Akt1) stimulated the CREB-dependent transcriptional activation of the gene encoding the E3 ubiquitin ligase RNF146. Chlorogenic acid 83-99 AKT serine/threonine kinase 1 Homo sapiens 37-41 33443209-5 2020 Overexpressing constitutively active Akt1 in SH-SY5Y cells or culturing cells with chlorogenic acid (a polyphenol found in coffee that activates Akt1) stimulated the CREB-dependent transcriptional activation of the gene encoding the E3 ubiquitin ligase RNF146. Chlorogenic acid 83-99 AKT serine/threonine kinase 1 Homo sapiens 145-149 33443209-7 2020 In mice, intraperitoneal administration of chlorogenic acid activated the Akt1-CREB-RNF146 pathway in the brain and provided neuroprotection against both 6-OHDA and combinatorial alpha-synucleinopathy in an RNF146-dependent manner. Chlorogenic acid 43-59 thymoma viral proto-oncogene 1 Mus musculus 74-78 33443209-7 2020 In mice, intraperitoneal administration of chlorogenic acid activated the Akt1-CREB-RNF146 pathway in the brain and provided neuroprotection against both 6-OHDA and combinatorial alpha-synucleinopathy in an RNF146-dependent manner. Chlorogenic acid 43-59 cAMP responsive element binding protein 1 Mus musculus 79-83 33443209-7 2020 In mice, intraperitoneal administration of chlorogenic acid activated the Akt1-CREB-RNF146 pathway in the brain and provided neuroprotection against both 6-OHDA and combinatorial alpha-synucleinopathy in an RNF146-dependent manner. Chlorogenic acid 43-59 ring finger protein 146 Mus musculus 84-90 33443209-7 2020 In mice, intraperitoneal administration of chlorogenic acid activated the Akt1-CREB-RNF146 pathway in the brain and provided neuroprotection against both 6-OHDA and combinatorial alpha-synucleinopathy in an RNF146-dependent manner. Chlorogenic acid 43-59 ring finger protein 146 Mus musculus 207-213 32981407-2 2020 OBJECTIVE: We investigated whether 5-CQA had a cytoprotective effect through the NF-E2-related factor 2 (Nrf2)-antioxidant response element (ARE) signalling pathway. Chlorogenic acid 35-40 NFE2 like bZIP transcription factor 2 Homo sapiens 81-103 33371201-0 2020 Caffeic and Chlorogenic Acids Synergistically Activate Browning Program in Human Adipocytes: Implications of AMPK- and PPAR-Mediated Pathways. Chlorogenic acid 12-29 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 109-113 33371201-0 2020 Caffeic and Chlorogenic Acids Synergistically Activate Browning Program in Human Adipocytes: Implications of AMPK- and PPAR-Mediated Pathways. Chlorogenic acid 12-29 peroxisome proliferator activated receptor alpha Homo sapiens 119-123 33371201-1 2020 Caffeic acid (CA) and chlorogenic acid (CGA) are phenolic compounds claimed to be responsible for the metabolic effects of coffee and tea consumption. Chlorogenic acid 22-38 chromogranin A Homo sapiens 40-43 32981407-2 2020 OBJECTIVE: We investigated whether 5-CQA had a cytoprotective effect through the NF-E2-related factor 2 (Nrf2)-antioxidant response element (ARE) signalling pathway. Chlorogenic acid 35-40 NFE2 like bZIP transcription factor 2 Homo sapiens 105-109 32981407-3 2020 MATERIALS AND METHODS: Nrf2 activation in response to 5-CQA treatment at the concentration of 10-100 muM is evaluated by Western blotting of Nrf2 and ARE reporter gene assay as well as its target gene expression in HepG2 cells. Chlorogenic acid 54-59 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 32981407-3 2020 MATERIALS AND METHODS: Nrf2 activation in response to 5-CQA treatment at the concentration of 10-100 muM is evaluated by Western blotting of Nrf2 and ARE reporter gene assay as well as its target gene expression in HepG2 cells. Chlorogenic acid 54-59 NFE2 like bZIP transcription factor 2 Homo sapiens 141-145 32981407-5 2020 The specific role of 5-CQA on Nrf2 activation was examined using Nrf2 knockout cells or Nrf2 specific inhibitor, ML-385. Chlorogenic acid 21-26 NFE2 like bZIP transcription factor 2 Homo sapiens 30-34 32981407-7 2020 Nrf2 deficiency or inhibition completely antagonized ability of 5-CQA to induce HO-1 and GCL expression. Chlorogenic acid 64-69 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 32981407-7 2020 Nrf2 deficiency or inhibition completely antagonized ability of 5-CQA to induce HO-1 and GCL expression. Chlorogenic acid 64-69 glutamate-cysteine ligase catalytic subunit Homo sapiens 89-92 32981407-10 2020 DISCUSSION AND CONCLUSIONS: Taken together, our results demonstrate that as a novel Nrf2 activator, 5-CQA, may be a promising candidate against oxidative stress-mediated liver injury. Chlorogenic acid 100-105 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 33015714-14 2020 CGA ameliorated AR-related symptoms in mice by regulating Th17 cells, which could be a candidate for the treatment of AR. Chlorogenic acid 0-3 ferredoxin reductase Mus musculus 16-18 32593042-0 2020 Covalent conjugation with (-)-epigallo-catechin 3-gallate and chlorogenic acid changes allergenicity and functional properties of Ara h1 from peanut. Chlorogenic acid 62-78 allergen Ara h 1, clone P17 Arachis hypogaea 130-136 33142463-5 2020 Besides, the expression level of IL-1beta mRNA showed significant increase during dihydromyricetin, chlorogenic acid, naringin, imiquimod, thymopentin, beta-D-Glucan, astragalus polysacharin, astragalus saponin I, astragalus flavone, curcumin, CpG-DNA-2, and LPS treatment. Chlorogenic acid 100-116 interleukin 1 alpha Homo sapiens 33-41 33240872-0 2020 Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway. Chlorogenic acid 0-16 microRNA 23a Mus musculus 107-114 33240872-0 2020 Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway. Chlorogenic acid 0-16 phosphatase and tensin homolog Mus musculus 115-119 33240872-0 2020 Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway. Chlorogenic acid 0-16 mitogen-activated protein kinase 14 Mus musculus 133-141 32882585-0 2020 Chlorogenic acid inhibits the proliferation of human lung cancer A549 cell lines by targeting annexin A2 in vitro and in vivo. Chlorogenic acid 0-16 annexin A2 Homo sapiens 94-104 32882585-5 2020 Consequently, we identified and verified annexin A2 as a covalent binding target of chlorogenic acid in A549 cells. Chlorogenic acid 84-100 annexin A2 Homo sapiens 41-51 32882585-6 2020 We also discovered that chlorogenic acid inhibits the binding of annexin A2 to p50 subunit thereby inhibiting the expression of downstream anti-apoptotic genes cIAP1 and cIAP2 of the NF-kappaB signaling pathway in A549 cells in vitro and in vivo. Chlorogenic acid 24-40 annexin A2 Homo sapiens 65-75 32882585-6 2020 We also discovered that chlorogenic acid inhibits the binding of annexin A2 to p50 subunit thereby inhibiting the expression of downstream anti-apoptotic genes cIAP1 and cIAP2 of the NF-kappaB signaling pathway in A549 cells in vitro and in vivo. Chlorogenic acid 24-40 nuclear factor kappa B subunit 1 Homo sapiens 79-82 32882585-6 2020 We also discovered that chlorogenic acid inhibits the binding of annexin A2 to p50 subunit thereby inhibiting the expression of downstream anti-apoptotic genes cIAP1 and cIAP2 of the NF-kappaB signaling pathway in A549 cells in vitro and in vivo. Chlorogenic acid 24-40 baculoviral IAP repeat containing 2 Homo sapiens 160-165 32882585-6 2020 We also discovered that chlorogenic acid inhibits the binding of annexin A2 to p50 subunit thereby inhibiting the expression of downstream anti-apoptotic genes cIAP1 and cIAP2 of the NF-kappaB signaling pathway in A549 cells in vitro and in vivo. Chlorogenic acid 24-40 baculoviral IAP repeat containing 3 Homo sapiens 170-175 32882585-6 2020 We also discovered that chlorogenic acid inhibits the binding of annexin A2 to p50 subunit thereby inhibiting the expression of downstream anti-apoptotic genes cIAP1 and cIAP2 of the NF-kappaB signaling pathway in A549 cells in vitro and in vivo. Chlorogenic acid 24-40 nuclear factor kappa B subunit 1 Homo sapiens 183-192 32882585-7 2020 Moreover, we found that chlorogenic acid hindered the binding of annexin A2 to actin possibly causing inhibition of tumor cell cycle and migration. Chlorogenic acid 24-40 annexin A2 Homo sapiens 65-75 32882585-8 2020 Thus, this work demonstrates that chlorogenic acid binds annexin A2, causing a decrease in the expression of NF-kappaB downstream anti-apoptotic genes, and inhibiting the proliferation of A549 cells in vivo and in vitro. Chlorogenic acid 34-50 annexin A2 Homo sapiens 57-67 32882585-8 2020 Thus, this work demonstrates that chlorogenic acid binds annexin A2, causing a decrease in the expression of NF-kappaB downstream anti-apoptotic genes, and inhibiting the proliferation of A549 cells in vivo and in vitro. Chlorogenic acid 34-50 nuclear factor kappa B subunit 1 Homo sapiens 109-118 32869889-5 2020 The preferred substrates for mPPO and the two sPPOs were catechol and chlorogenic acid, respectively. Chlorogenic acid 70-86 protoporphyrinogen oxidase Mus musculus 29-33 33142463-6 2020 And the level of caspase 3 protein was significantly upregulated with treating chlorogenic acid, beta-D-Glucan, astragalus polysacharin, astragalus flavone, curcumin, CpG-DNA-2, chicken IgG, LPS, and poly(I:C). Chlorogenic acid 79-95 caspase 3 Homo sapiens 17-26 33142463-6 2020 And the level of caspase 3 protein was significantly upregulated with treating chlorogenic acid, beta-D-Glucan, astragalus polysacharin, astragalus flavone, curcumin, CpG-DNA-2, chicken IgG, LPS, and poly(I:C). Chlorogenic acid 79-95 DNA replication helicase/nuclease 2 Homo sapiens 171-176 33097741-9 2020 The combination of CHA and SYG possibly induces anxiolytic behavior and modulates autonomic regulation, activates hippocampal BDNF signaling as with ASH. Chlorogenic acid 19-22 brain-derived neurotrophic factor Rattus norvegicus 126-130 33126534-2 2020 Studies support the hypoglycemic effect of Cynarascolymus (Cs) extracts due to the content of chlorogenic acid, which is a potent inhibitor of glucose 6-phosphate translocase and of dicaffeoylquinic acid derivatives that modulate the activity of alpha-glucosidase. Chlorogenic acid 94-110 sucrase-isomaltase Homo sapiens 246-263 33097741-0 2020 Combination of syringaresinol-di-O-beta-D-glucoside and chlorogenic acid shows behavioral pharmacological anxiolytic activity and activation of hippocampal BDNF-TrkB signaling. Chlorogenic acid 56-72 brain-derived neurotrophic factor Rattus norvegicus 156-160 33342809-0 2020 Chlorogenic acid inhibits growth of 4T1 breast cancer cells through involvement in Bax/Bcl2 pathway. Chlorogenic acid 0-16 BCL2-associated X protein Mus musculus 83-86 33342809-0 2020 Chlorogenic acid inhibits growth of 4T1 breast cancer cells through involvement in Bax/Bcl2 pathway. Chlorogenic acid 0-16 B cell leukemia/lymphoma 2 Mus musculus 87-91 33342809-10 2020 Immunocytochemistry results showed the upregulation of Bax and also the downregulation of Bcl-2 in 4T1 cells treated with chlorogenic acid (P < 0.001). Chlorogenic acid 122-138 BCL2-associated X protein Mus musculus 55-58 33342809-10 2020 Immunocytochemistry results showed the upregulation of Bax and also the downregulation of Bcl-2 in 4T1 cells treated with chlorogenic acid (P < 0.001). Chlorogenic acid 122-138 B cell leukemia/lymphoma 2 Mus musculus 90-95 33342809-11 2020 The expression level of P53 and caspase-3 increased during treatment with chlorogenic acid in the 4T1 cells (P < 0.001). Chlorogenic acid 74-90 transformation related protein 53, pseudogene Mus musculus 24-27 33342809-11 2020 The expression level of P53 and caspase-3 increased during treatment with chlorogenic acid in the 4T1 cells (P < 0.001). Chlorogenic acid 74-90 caspase 3 Mus musculus 32-41 33054539-0 2020 Chlorogenic Acid Improves Symptoms of Inflammatory Bowel Disease in Interleukin-10 Knockout Mice. Chlorogenic acid 0-16 interleukin 10 Mus musculus 68-82 33054539-3 2020 In this study, we investigated whether chlorogenic acid (CHA) can regulate inflammation in IL-10 knockout (KO) mice used as an IBD animal model. Chlorogenic acid 39-55 interleukin 10 Mus musculus 91-96 33054539-3 2020 In this study, we investigated whether chlorogenic acid (CHA) can regulate inflammation in IL-10 knockout (KO) mice used as an IBD animal model. Chlorogenic acid 57-60 interleukin 10 Mus musculus 91-96 33054539-4 2020 CHA significantly increased the ratio of CD4+/CD8+, T cell subsets in PP, and MLN of IL-10 KO mice. Chlorogenic acid 0-3 CD4 antigen Mus musculus 41-44 33054539-4 2020 CHA significantly increased the ratio of CD4+/CD8+, T cell subsets in PP, and MLN of IL-10 KO mice. Chlorogenic acid 0-3 interleukin 10 Mus musculus 85-90 33054539-5 2020 In addition, CHA also morphologically attenuated colon inflammation in IL-10 KO mice. Chlorogenic acid 13-16 interleukin 10 Mus musculus 71-76 33054539-6 2020 We demonstrated that CHA significantly reduced the expression levels of iNOS, IL-1beta, TNF-alpha, which were highly expressed in IL-10 KO mice. Chlorogenic acid 21-24 nitric oxide synthase 2, inducible Mus musculus 72-76 33054539-6 2020 We demonstrated that CHA significantly reduced the expression levels of iNOS, IL-1beta, TNF-alpha, which were highly expressed in IL-10 KO mice. Chlorogenic acid 21-24 interleukin 1 alpha Mus musculus 78-86 33054539-6 2020 We demonstrated that CHA significantly reduced the expression levels of iNOS, IL-1beta, TNF-alpha, which were highly expressed in IL-10 KO mice. Chlorogenic acid 21-24 tumor necrosis factor Mus musculus 88-97 33054539-6 2020 We demonstrated that CHA significantly reduced the expression levels of iNOS, IL-1beta, TNF-alpha, which were highly expressed in IL-10 KO mice. Chlorogenic acid 21-24 interleukin 10 Mus musculus 130-135 33078870-0 2020 Chlorogenic Acid Suppresses miR-155 and Ameliorates Ulcerative Colitis Through the NF-kappaB/NLRP3 inflammasome Pathway. Chlorogenic acid 0-16 microRNA 155 Mus musculus 28-35 33078870-0 2020 Chlorogenic Acid Suppresses miR-155 and Ameliorates Ulcerative Colitis Through the NF-kappaB/NLRP3 inflammasome Pathway. Chlorogenic acid 0-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 83-92 33078870-0 2020 Chlorogenic Acid Suppresses miR-155 and Ameliorates Ulcerative Colitis Through the NF-kappaB/NLRP3 inflammasome Pathway. Chlorogenic acid 0-16 NLR family, pyrin domain containing 3 Mus musculus 93-98 32627855-2 2020 In this study, the effects of three common caffeoylquinic acids (CQAs) (chlorogenic acid, isochlorogenic acid A, and cynarin) on alpha-glucosidase activity and glucose consumption in HepG2 cells were systematically compared. Chlorogenic acid 72-88 sucrase-isomaltase Homo sapiens 129-146 33116107-10 2020 It was suggested that chlorogenic acid of green coffee seed can protect kidney through down regulation of p53 transcription factor and thereby attenuation of oxidative stress, inflammation and apoptotic process in renal tubules. Chlorogenic acid 22-38 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 106-109 32999301-5 2020 Additionally, the transcriptional analysis of thirteen genes controlling the phenylpropanoid, chlorogenic acid and flavonoid biosynthetic pathways revealed that most of the studied genes were induced after POT1 treatments. Chlorogenic acid 94-110 protection of telomeres 1 Homo sapiens 206-210 32603696-0 2020 Chlorogenic acid alleviates acetaminophen-induced liver injury in mice via regulating Nrf2-mediated HSP60-initiated liver inflammation. Chlorogenic acid 0-16 nuclear factor, erythroid derived 2, like 2 Mus musculus 86-90 32603696-0 2020 Chlorogenic acid alleviates acetaminophen-induced liver injury in mice via regulating Nrf2-mediated HSP60-initiated liver inflammation. Chlorogenic acid 0-16 heat shock protein 1 (chaperonin) Mus musculus 100-105 32899726-0 2020 Chlorogenic Acid Potentiates the Anti-Inflammatory Activity of Curcumin in LPS-Stimulated THP-1 Cells. Chlorogenic acid 0-16 GLI family zinc finger 2 Homo sapiens 90-95 32627855-3 2020 Their alpha-glucosidase inhibitory activities followed the order of isochlorogenic acid A > chlorogenic acid > cynarin. Chlorogenic acid 71-87 sucrase-isomaltase Homo sapiens 6-23 32868754-0 2020 Chlorogenic Acid Alleviates Allergic Inflammatory Responses Through Regulating Th1/Th2 Balance in Ovalbumin-Induced Allergic Rhinitis Mice. Chlorogenic acid 0-16 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 98-107 32868754-11 2020 RESULTS In the OVA-induced AR mice, CGA treatment reduced nasal rubbing and sneezing, and also suppressed the number of total cells, eosinophils, neutrophils, lymphocytes, macrophages, and epithelial cells in NALF. Chlorogenic acid 36-39 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 15-18 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. Chlorogenic acid 47-63 tumor necrosis factor Homo sapiens 206-227 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. Chlorogenic acid 47-63 tumor necrosis factor Homo sapiens 228-237 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. Chlorogenic acid 47-63 interleukin 1 alpha Homo sapiens 240-260 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. Chlorogenic acid 47-63 interleukin 6 Homo sapiens 266-270 32421102-16 2020 The results of molecular docking virtual calculation showed that phillyrin and chlorogenic acid could stably combine with Gln325 and Gln42/Asp38 in ACE2, respectively, which hindered the combination between S- protein and ACE2. Chlorogenic acid 79-95 angiotensin converting enzyme 2 Homo sapiens 148-152 32746727-2 2021 The aim of this study was to investigate the effect of hydroquinone, 4-hydroxybenzoic acid, 3,5-dihydroxybenzoic acid, caffeic acid, vanillic acid and chlorogenic acid against acetylcholinesterase (AChE), partially purified from serum. Chlorogenic acid 151-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 32746727-4 2021 Hydroquinone, chlorogenic acid and 4-hydroxybenzoic acid have been found to have higher inhibitory potential than others against the AChE. Chlorogenic acid 14-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 32421102-16 2020 The results of molecular docking virtual calculation showed that phillyrin and chlorogenic acid could stably combine with Gln325 and Gln42/Asp38 in ACE2, respectively, which hindered the combination between S- protein and ACE2. Chlorogenic acid 79-95 angiotensin converting enzyme 2 Homo sapiens 222-226 32421102-17 2020 Conclusion: Phillyrin and chlorogenic acid can effectively prevent the combination of SARS-CoV-2 S-protein and ACE2 at the molecular level. Chlorogenic acid 26-42 vitronectin Homo sapiens 97-106 32421102-17 2020 Conclusion: Phillyrin and chlorogenic acid can effectively prevent the combination of SARS-CoV-2 S-protein and ACE2 at the molecular level. Chlorogenic acid 26-42 angiotensin converting enzyme 2 Homo sapiens 111-115 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 55-71 mitogen-activated protein kinase 8 Homo sapiens 107-128 33102196-9 2020 Docking tests confirmed that quercetin, chlorogenic acid, epicatechin, and catechins depicted HMGR inhibition. Chlorogenic acid 40-56 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like Malus domestica 94-98 32417323-0 2020 Corrigendum to "Chlorogenic acid attenuates diabetic retinopathy by reducing VEGF expression and inhibiting VEGF-mediated retinal neoangiogenesis" [Vascul. Chlorogenic acid 16-32 vascular endothelial growth factor A Homo sapiens 77-81 32417323-0 2020 Corrigendum to "Chlorogenic acid attenuates diabetic retinopathy by reducing VEGF expression and inhibiting VEGF-mediated retinal neoangiogenesis" [Vascul. Chlorogenic acid 16-32 vascular endothelial growth factor A Homo sapiens 108-112 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 55-71 mitogen-activated protein kinase 8 Homo sapiens 129-132 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 55-71 interleukin 1 alpha Homo sapiens 151-155 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 55-71 interleukin 6 Homo sapiens 253-257 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 55-71 C-reactive protein Homo sapiens 301-319 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 55-71 C-reactive protein Homo sapiens 320-323 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 55-71 interleukin 6 Homo sapiens 342-346 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 mitogen-activated protein kinase 8 Homo sapiens 107-128 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 mitogen-activated protein kinase 8 Homo sapiens 129-132 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 interleukin 1 alpha Homo sapiens 151-155 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 interleukin 6 Homo sapiens 253-257 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 C-reactive protein Homo sapiens 301-319 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 C-reactive protein Homo sapiens 320-323 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 interleukin 6 Homo sapiens 342-346 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 mitogen-activated protein kinase 8 Homo sapiens 107-128 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 mitogen-activated protein kinase 8 Homo sapiens 129-132 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 interleukin 1 alpha Homo sapiens 151-155 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 interleukin 6 Homo sapiens 253-257 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 C-reactive protein Homo sapiens 301-319 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 C-reactive protein Homo sapiens 320-323 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic acid 178-194 interleukin 6 Homo sapiens 342-346 32726040-6 2020 It revealed that the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-1 signaling pathway were chlorogenic acid and linalool, and the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-6 signaling pathway were chlorogenic acid and luteolin. Chlorogenic acid 153-169 interleukin 1 alpha Homo sapiens 125-129 32583704-3 2021 However, there is little information about the potential effects of several coffee compounds (e.g. kahweol, cafestol, trigonelline, niacin and chlorogenic acids) on IL-2 expression in activated T-lymphocytic cells. Chlorogenic acid 143-160 interleukin 2 Homo sapiens 165-169 32655395-0 2020 Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression. Chlorogenic acid 0-16 DNA methyltransferase 1 Homo sapiens 101-106 32630570-0 2020 The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway. Chlorogenic acid 25-41 nuclear factor, erythroid derived 2, like 2 Mus musculus 73-77 32630570-0 2020 The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway. Chlorogenic acid 25-41 heme oxygenase 1 Mus musculus 78-82 32440096-0 2020 Chlorogenic Acid Alleviates Abeta25-35-Induced Autophagy and Cognitive Impairment via the mTOR/TFEB Signaling Pathway. Chlorogenic acid 0-16 transcription factor EB Mus musculus 95-99 32440096-8 2020 Results: CGA treatment significantly improved spatial memory, relieved neuron damage, and inhibited autophagy in APP/PS1 mice (P<0.05). Chlorogenic acid 9-12 presenilin 1 Mus musculus 117-120 33191230-5 2020 Chlorogenic acid also inhibited the mRNA levels of hepatic G-6-Pase and up-regulated the mRNA levels of skeletal muscle GLUT4. Chlorogenic acid 0-16 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 59-67 32143102-6 2020 Western blot analysis suggested chlorogenic acid could rescue the up-regulated apoptosis of GCs induced by ZEA via attenuating the protein expression of cleaved caspase-3, the ratio of Bax/Bcl-2 and cleaved-PARP. Chlorogenic acid 32-48 caspase 3 Mus musculus 161-170 32143102-6 2020 Western blot analysis suggested chlorogenic acid could rescue the up-regulated apoptosis of GCs induced by ZEA via attenuating the protein expression of cleaved caspase-3, the ratio of Bax/Bcl-2 and cleaved-PARP. Chlorogenic acid 32-48 BCL2-associated X protein Mus musculus 185-188 32143102-6 2020 Western blot analysis suggested chlorogenic acid could rescue the up-regulated apoptosis of GCs induced by ZEA via attenuating the protein expression of cleaved caspase-3, the ratio of Bax/Bcl-2 and cleaved-PARP. Chlorogenic acid 32-48 B cell leukemia/lymphoma 2 Mus musculus 189-194 32143102-6 2020 Western blot analysis suggested chlorogenic acid could rescue the up-regulated apoptosis of GCs induced by ZEA via attenuating the protein expression of cleaved caspase-3, the ratio of Bax/Bcl-2 and cleaved-PARP. Chlorogenic acid 32-48 poly (ADP-ribose) polymerase family, member 1 Mus musculus 207-211 32471962-0 2020 Chlorogenic acid attenuates kidney fibrosis via antifibrotic action of BMP-7 and HGF. Chlorogenic acid 0-16 bone morphogenetic protein 7 Mus musculus 71-76 32471962-0 2020 Chlorogenic acid attenuates kidney fibrosis via antifibrotic action of BMP-7 and HGF. Chlorogenic acid 0-16 hepatocyte growth factor Mus musculus 81-84 33191230-5 2020 Chlorogenic acid also inhibited the mRNA levels of hepatic G-6-Pase and up-regulated the mRNA levels of skeletal muscle GLUT4. Chlorogenic acid 0-16 solute carrier family 2 member 4 Rattus norvegicus 120-125 32306009-1 2020 OBJECTIVE: To observe the effect of chlorogenic acid (chlorogenic acid, CGA) on the glucose tolerance and its curve characteristics in high fat diet-induced obesity (diet-induced-obesity, DIO) rats, so as to provide scientific grounds for the development and utilization of CGA in early prevention and reversal of prediabetes. Chlorogenic acid 36-52 chromogranin A Rattus norvegicus 72-75 32201030-0 2020 Corrigendum to "Effects of chlorogenic acid on thermal stress tolerance in C. elegans via HIF-1, HSF-1 and autophagy" [Phytomedicine 66 (2020) 153132]. Chlorogenic acid 27-43 Hypoxia-inducible factor 1 Caenorhabditis elegans 90-95 32337685-8 2020 Kinetic data showed that tyrosinase had the greatest substrate affnity to chlorogenic acid compared with its isomers and caffeic acid. Chlorogenic acid 74-90 tyrosinase Homo sapiens 25-35 31602671-0 2020 Chlorogenic acid activates ERK1/2 and inhibits proliferation of osteosarcoma cells. Chlorogenic acid 0-16 mitogen-activated protein kinase 3 Homo sapiens 27-33 32201030-0 2020 Corrigendum to "Effects of chlorogenic acid on thermal stress tolerance in C. elegans via HIF-1, HSF-1 and autophagy" [Phytomedicine 66 (2020) 153132]. Chlorogenic acid 27-43 Heat shock transcription factor hsf-1 Caenorhabditis elegans 97-102 31707349-0 2020 Chlorogenic acid inhibits esophageal squamous cell carcinoma growth in vitro and in vivo by downregulating the expression of BMI1 and SOX2. Chlorogenic acid 0-16 Bmi1 polycomb ring finger oncogene Mus musculus 125-129 32350149-14 2020 Western blot analysis showed significant decreases of COX-2 in inflamed skin and kidney in the groups of rats that received indomethacin or 100 mg/day of chlorogenic acid. Chlorogenic acid 154-170 cytochrome c oxidase II, mitochondrial Rattus norvegicus 54-59 32117796-7 2020 Linarin, sinensetin, cedar acid, isoliquiritigenin, sinigrin, luteolin, chlorogenic acid, orientin, epigoitrin, and rupestonic acid exhibited significant effects on TNF-alpha expression, which is almost consistent with predicted results. Chlorogenic acid 72-88 tumor necrosis factor Homo sapiens 165-174 32021091-0 2020 Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway. Chlorogenic acid 22-38 NFE2 like bZIP transcription factor 2 Rattus norvegicus 123-127 31541942-8 2020 This method was successfully applied to pharmacokinetic study of CGA in Chinese subjects with advanced solid tumor after intramuscular injection administration of Chlorogenic acid for injection (CAFI). Chlorogenic acid 163-179 chromogranin A Homo sapiens 65-68 31707349-0 2020 Chlorogenic acid inhibits esophageal squamous cell carcinoma growth in vitro and in vivo by downregulating the expression of BMI1 and SOX2. Chlorogenic acid 0-16 SRY (sex determining region Y)-box 2 Mus musculus 134-138 31766098-11 2020 DFSG and a mixture of caffeic acid, p-coumaric acid, and chlorogenic acid inhibited MUC5AC gene expression in A549 cells after stimulation with IL-1beta. Chlorogenic acid 57-73 mucin 5, subtypes A and C, tracheobronchial/gastric Mus musculus 84-90 31707349-8 2020 Together, our initial findings demonstrate that CGA suppresses ESCC progression, downregulates the expression of BMI1 and SOX2, and provide an anti-tumor candidate for ESCC therapy. Chlorogenic acid 48-51 Bmi1 polycomb ring finger oncogene Mus musculus 113-117 31766098-11 2020 DFSG and a mixture of caffeic acid, p-coumaric acid, and chlorogenic acid inhibited MUC5AC gene expression in A549 cells after stimulation with IL-1beta. Chlorogenic acid 57-73 interleukin 1 beta Mus musculus 144-152 31707349-8 2020 Together, our initial findings demonstrate that CGA suppresses ESCC progression, downregulates the expression of BMI1 and SOX2, and provide an anti-tumor candidate for ESCC therapy. Chlorogenic acid 48-51 SRY (sex determining region Y)-box 2 Mus musculus 122-126 31790899-0 2020 Effects of chlorogenic acid on thermal stress tolerance in C. elegans via HIF-1, HSF-1 and autophagy. Chlorogenic acid 11-27 Hypoxia-inducible factor 1 Caenorhabditis elegans 74-79 32188382-7 2020 And, chlorogenic acid can reduce the mRNA and proteins levels of PGC-1alpha and UCP-1 in the MSG-induced obese mice and oleic acid-induced human fatty liver HepG2 cells. Chlorogenic acid 5-21 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 65-75 32188382-7 2020 And, chlorogenic acid can reduce the mRNA and proteins levels of PGC-1alpha and UCP-1 in the MSG-induced obese mice and oleic acid-induced human fatty liver HepG2 cells. Chlorogenic acid 5-21 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 80-85 32188382-8 2020 CONCLUSION: Based on the above results, we deduced chlorogenic acid could improve blood lipid and liver function in obese, the mechanism may be related to PGC-1alpha/UCP-1 pathway. Chlorogenic acid 51-67 PPARG coactivator 1 alpha Homo sapiens 155-165 32188382-8 2020 CONCLUSION: Based on the above results, we deduced chlorogenic acid could improve blood lipid and liver function in obese, the mechanism may be related to PGC-1alpha/UCP-1 pathway. Chlorogenic acid 51-67 uncoupling protein 1 Homo sapiens 166-171 31790899-0 2020 Effects of chlorogenic acid on thermal stress tolerance in C. elegans via HIF-1, HSF-1 and autophagy. Chlorogenic acid 11-27 Heat shock transcription factor hsf-1 Caenorhabditis elegans 81-86 31790899-6 2020 CGA-induced thermotolerance required hypoxia-inducible factor HIF-1 but no insulin pathway. Chlorogenic acid 0-3 Hypoxia-inducible factor 1 Caenorhabditis elegans 62-67 31790899-7 2020 CGA exposition (1.4 microM CGA for 18 h) before thermal stress treatment increased HIF-1 levels and activity. Chlorogenic acid 0-3 Hypoxia-inducible factor 1 Caenorhabditis elegans 83-88 31790899-7 2020 CGA exposition (1.4 microM CGA for 18 h) before thermal stress treatment increased HIF-1 levels and activity. Chlorogenic acid 27-30 Hypoxia-inducible factor 1 Caenorhabditis elegans 83-88 31790899-9 2020 In addition, CGA exposition before thermal stress also increased autophagy just as hormetic heat condition (HHC), worms incubated at 36 C for 1 h. RNAi experiments evidenced that autophagy was increased by CGA via HIF-1, heat-shock transcription factor HSF-1 and heat-shock protein HSP-16 and HSP-70. Chlorogenic acid 13-16 Hypoxia-inducible factor 1 Caenorhabditis elegans 215-220 31790899-9 2020 In addition, CGA exposition before thermal stress also increased autophagy just as hormetic heat condition (HHC), worms incubated at 36 C for 1 h. RNAi experiments evidenced that autophagy was increased by CGA via HIF-1, heat-shock transcription factor HSF-1 and heat-shock protein HSP-16 and HSP-70. Chlorogenic acid 13-16 Heat shock transcription factor hsf-1 Caenorhabditis elegans 254-259 31790899-9 2020 In addition, CGA exposition before thermal stress also increased autophagy just as hormetic heat condition (HHC), worms incubated at 36 C for 1 h. RNAi experiments evidenced that autophagy was increased by CGA via HIF-1, heat-shock transcription factor HSF-1 and heat-shock protein HSP-16 and HSP-70. Chlorogenic acid 13-16 Heat Shock Protein Caenorhabditis elegans 294-300 31790899-9 2020 In addition, CGA exposition before thermal stress also increased autophagy just as hormetic heat condition (HHC), worms incubated at 36 C for 1 h. RNAi experiments evidenced that autophagy was increased by CGA via HIF-1, heat-shock transcription factor HSF-1 and heat-shock protein HSP-16 and HSP-70. Chlorogenic acid 207-210 Hypoxia-inducible factor 1 Caenorhabditis elegans 215-220 31790899-9 2020 In addition, CGA exposition before thermal stress also increased autophagy just as hormetic heat condition (HHC), worms incubated at 36 C for 1 h. RNAi experiments evidenced that autophagy was increased by CGA via HIF-1, heat-shock transcription factor HSF-1 and heat-shock protein HSP-16 and HSP-70. Chlorogenic acid 207-210 Heat shock transcription factor hsf-1 Caenorhabditis elegans 254-259 31790899-9 2020 In addition, CGA exposition before thermal stress also increased autophagy just as hormetic heat condition (HHC), worms incubated at 36 C for 1 h. RNAi experiments evidenced that autophagy was increased by CGA via HIF-1, heat-shock transcription factor HSF-1 and heat-shock protein HSP-16 and HSP-70. Chlorogenic acid 207-210 Heat Shock Protein Caenorhabditis elegans 294-300 31790899-12 2020 CONCLUSION: This study demonstrates that CGA-induced thermotolerance in C. elegans is mediated by HIF-1 and downstream, by HSF-1, HSPs and autophagy resembling HHC. Chlorogenic acid 41-44 Hypoxia-inducible factor 1 Caenorhabditis elegans 98-103 31790899-12 2020 CONCLUSION: This study demonstrates that CGA-induced thermotolerance in C. elegans is mediated by HIF-1 and downstream, by HSF-1, HSPs and autophagy resembling HHC. Chlorogenic acid 41-44 Heat shock transcription factor hsf-1 Caenorhabditis elegans 123-128 31867307-3 2019 This study investigated the binding mechanism of three CQAs, including chlorogenic acid, neochlorogenic acid, and cryptochlorogenic acid, with bovine serum albumin (BSA) by using multi-spectroscopic techniques, including fluorescence, UV-Vis, Fourier transform infrared (FT-IR) and circular dichroism (CD) spectroscopy, LC-MSn, molecular docking and antioxidant activity assessment. Chlorogenic acid 71-87 albumin Bos taurus 150-163 31366075-1 2019 The aim of this study was to estimate the mode of thyroid peroxidase (TPO) inhibition by polyphenols: Chlorogenic acid, rosmarinic acid, quercetin, and rutin. Chlorogenic acid 102-118 thyroid peroxidase Homo sapiens 70-73 31670366-0 2019 Collaborative effects of chlorogenic acid and caffeine on lipid metabolism via the AMPKalpha-LXRalpha/SREBP-1c pathway in high-fat diet-induced obese mice. Chlorogenic acid 25-41 sterol regulatory element binding transcription factor 1 Mus musculus 102-110 31196425-5 2019 Under optimized conditions, the fabricated sensor displays two wide linear responses in the ranges of 5.8-733.8 muM and 733.8-2933.8 muM for hydroxylamine, with a rapid response time about 1 s. For chlorogenic acid, the sensor presents linear responses in the ranges of 0.1-2 muM and 2-15 muM, with a high sensitivity of 10.18 muA/muM. Chlorogenic acid 198-214 latexin Homo sapiens 112-115 31196425-5 2019 Under optimized conditions, the fabricated sensor displays two wide linear responses in the ranges of 5.8-733.8 muM and 733.8-2933.8 muM for hydroxylamine, with a rapid response time about 1 s. For chlorogenic acid, the sensor presents linear responses in the ranges of 0.1-2 muM and 2-15 muM, with a high sensitivity of 10.18 muA/muM. Chlorogenic acid 198-214 latexin Homo sapiens 133-136 31196425-5 2019 Under optimized conditions, the fabricated sensor displays two wide linear responses in the ranges of 5.8-733.8 muM and 733.8-2933.8 muM for hydroxylamine, with a rapid response time about 1 s. For chlorogenic acid, the sensor presents linear responses in the ranges of 0.1-2 muM and 2-15 muM, with a high sensitivity of 10.18 muA/muM. Chlorogenic acid 198-214 latexin Homo sapiens 133-136 31196425-5 2019 Under optimized conditions, the fabricated sensor displays two wide linear responses in the ranges of 5.8-733.8 muM and 733.8-2933.8 muM for hydroxylamine, with a rapid response time about 1 s. For chlorogenic acid, the sensor presents linear responses in the ranges of 0.1-2 muM and 2-15 muM, with a high sensitivity of 10.18 muA/muM. Chlorogenic acid 198-214 latexin Homo sapiens 133-136 31196425-5 2019 Under optimized conditions, the fabricated sensor displays two wide linear responses in the ranges of 5.8-733.8 muM and 733.8-2933.8 muM for hydroxylamine, with a rapid response time about 1 s. For chlorogenic acid, the sensor presents linear responses in the ranges of 0.1-2 muM and 2-15 muM, with a high sensitivity of 10.18 muA/muM. Chlorogenic acid 198-214 latexin Homo sapiens 133-136 31234064-4 2019 In vitro experiments and cell adhesion/proliferation evaluation reveal that the chlorogenic acid-sodium alginate-peptide bridging system shows better bioaffinity than the control groups due to the BFP peptide on the surface of the hydrogel. Chlorogenic acid 80-96 ring finger protein 112 Homo sapiens 197-200 31766780-9 2019 The chlorogenic acid isomers and caffeic acid inhibited the TNF release, with cryptochlorogenic acid exerting the most distinct effects, as well as decreasing the release of IL-6 and MCP-1. Chlorogenic acid 4-20 tumor necrosis factor Homo sapiens 60-63 31574257-8 2019 We then characterize three compounds, 3"-nitrophthalanilic acid, chlorogenic acid and caffeic acid that affect DPPI activity via kinetic mechanisms consistent with binding outside of the active site. Chlorogenic acid 65-81 cathepsin C Homo sapiens 111-115 31366075-4 2019 Rutin and rosmarinic acid showed competitive, quercetin-uncompetitive and chlorogenic acid-noncompetitive inhibition effect on TPO. Chlorogenic acid 74-90 thyroid peroxidase Homo sapiens 127-130 31315279-0 2019 Coffee Abundant in Chlorogenic Acids Reduces Abdominal Fat in Overweight Adults: A Randomized, Double-Blind, Controlled Trial. Chlorogenic acid 19-36 FAT atypical cadherin 1 Homo sapiens 55-58 31315279-2 2019 We investigated the effects of daily consumption of coffee enriched in chlorogenic acids (CGA) on abdominal fat area in a randomized, double-blind, parallel controlled trial. Chlorogenic acid 71-88 FAT atypical cadherin 1 Homo sapiens 108-111 30951611-0 2019 Reversing ROS-mediated neurotoxicity by chlorogenic acid involves its direct antioxidant activity and activation of Nrf2-ARE signaling pathway. Chlorogenic acid 40-56 NFE2 like bZIP transcription factor 2 Rattus norvegicus 116-120 30582213-0 2019 Chlorogenic acid inhibits osteosarcoma carcinogenesis via suppressing the STAT3/Snail pathway. Chlorogenic acid 0-16 signal transducer and activator of transcription 3 Homo sapiens 74-79 31055996-0 2019 Chlorogenic acid relieved oxidative stress injury in retinal ganglion cells through IncRNA-TUG1/Nrf2. Chlorogenic acid 0-16 taurine upregulated gene 1 Mus musculus 91-95 31055996-0 2019 Chlorogenic acid relieved oxidative stress injury in retinal ganglion cells through IncRNA-TUG1/Nrf2. Chlorogenic acid 0-16 nuclear factor, erythroid derived 2, like 2 Mus musculus 96-100 30989669-0 2019 Chlorogenic acid inhibits proliferation and induces apoptosis in A498 human kidney cancer cells via inactivating PI3K/Akt/mTOR signalling pathway. Chlorogenic acid 0-16 AKT serine/threonine kinase 1 Homo sapiens 118-121 30989669-0 2019 Chlorogenic acid inhibits proliferation and induces apoptosis in A498 human kidney cancer cells via inactivating PI3K/Akt/mTOR signalling pathway. Chlorogenic acid 0-16 mechanistic target of rapamycin kinase Homo sapiens 122-126 31168914-0 2019 Attenuation of Palmitic Acid-Induced Lipotoxicity by Chlorogenic Acid through Activation of SIRT1 in Hepatocytes. Chlorogenic acid 53-69 sirtuin 1 Mus musculus 92-97 31146527-7 2019 Of the three key LCBP components investigated, chlorogenic acid was found to activate SIRT1 and regulate the expression of the cholesterol-related factors ABCA1, SREBP2, and miR-33; cyanidin-3-glucoside and catechins were effective to a lesser extent. Chlorogenic acid 47-63 sirtuin 1 Mus musculus 86-91 31146527-7 2019 Of the three key LCBP components investigated, chlorogenic acid was found to activate SIRT1 and regulate the expression of the cholesterol-related factors ABCA1, SREBP2, and miR-33; cyanidin-3-glucoside and catechins were effective to a lesser extent. Chlorogenic acid 47-63 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 155-160 31146527-7 2019 Of the three key LCBP components investigated, chlorogenic acid was found to activate SIRT1 and regulate the expression of the cholesterol-related factors ABCA1, SREBP2, and miR-33; cyanidin-3-glucoside and catechins were effective to a lesser extent. Chlorogenic acid 47-63 sterol regulatory element binding factor 2 Mus musculus 162-168 31146527-7 2019 Of the three key LCBP components investigated, chlorogenic acid was found to activate SIRT1 and regulate the expression of the cholesterol-related factors ABCA1, SREBP2, and miR-33; cyanidin-3-glucoside and catechins were effective to a lesser extent. Chlorogenic acid 47-63 microRNA 33 Mus musculus 174-180 32269953-0 2020 Adaptive immunoregulation of luteolin and chlorogenic acid in lipopolysaccharide-induced interleukin-10 expression. Chlorogenic acid 42-58 interleukin 10 Mus musculus 89-103 30722900-3 2019 It was found that binding of tannic acid, chlorogenic acid, caffeic acid and epicatechin with alpha-amylase is an exothermal process, with the binding constants in the order of tannic acid > chlorogenic acid > caffeic acid > epicatechin. Chlorogenic acid 42-58 probable alpha-amylase 2 Malus domestica 94-107 30722900-3 2019 It was found that binding of tannic acid, chlorogenic acid, caffeic acid and epicatechin with alpha-amylase is an exothermal process, with the binding constants in the order of tannic acid > chlorogenic acid > caffeic acid > epicatechin. Chlorogenic acid 194-210 probable alpha-amylase 2 Malus domestica 94-107 31004750-0 2019 Chlorogenic acid promotes the Nrf2/HO-1 anti-oxidative pathway by activating p21Waf1/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells. Chlorogenic acid 0-16 nuclear factor, erythroid derived 2, like 2 Mus musculus 30-34 31004750-0 2019 Chlorogenic acid promotes the Nrf2/HO-1 anti-oxidative pathway by activating p21Waf1/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells. Chlorogenic acid 0-16 heme oxygenase 1 Mus musculus 35-39 31004750-0 2019 Chlorogenic acid promotes the Nrf2/HO-1 anti-oxidative pathway by activating p21Waf1/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells. Chlorogenic acid 0-16 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 77-89 31004750-2 2019 Chlorogenic acid (CGA) has a strong protective effect on osteoporosis, closely related to activating the Nrf2/HO-1 pathway. Chlorogenic acid 0-16 nuclear factor, erythroid derived 2, like 2 Mus musculus 105-109 31004750-2 2019 Chlorogenic acid (CGA) has a strong protective effect on osteoporosis, closely related to activating the Nrf2/HO-1 pathway. Chlorogenic acid 0-16 heme oxygenase 1 Mus musculus 110-114 31033175-0 2019 Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF-alpha-induced injury via inhibiting NF-kappaB and JNK signals. Chlorogenic acid 0-16 tumor necrosis factor Homo sapiens 70-79 31033175-0 2019 Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF-alpha-induced injury via inhibiting NF-kappaB and JNK signals. Chlorogenic acid 0-16 mitogen-activated protein kinase 8 Homo sapiens 124-127 30895499-0 2019 Chlorogenic acid isomers directly interact with Keap 1-Nrf2 signaling in Caco-2 cells. Chlorogenic acid 0-16 kelch like ECH associated protein 1 Homo sapiens 48-54 30895499-0 2019 Chlorogenic acid isomers directly interact with Keap 1-Nrf2 signaling in Caco-2 cells. Chlorogenic acid 0-16 NFE2 like bZIP transcription factor 2 Homo sapiens 55-59 30949934-11 2019 Docking studies confirmed chlorogenic acid has the most significant binding affinity towards AChE. Chlorogenic acid 26-42 acetylcholinesterase Mus musculus 93-97 31261680-0 2019 Chlorogenic Acid Alleviates Thiram-Induced Tibial Dyschondroplasia by Modulating Caspases, BECN1 Expression and ECM Degradation. Chlorogenic acid 0-16 beclin 1 Gallus gallus 91-96 31106605-0 2019 Chlorogenic acid prevents paraquat-induced apoptosis via Sirt1-mediated regulation of redox and mitochondrial function. Chlorogenic acid 0-16 sirtuin 1 Homo sapiens 57-62 30582213-0 2019 Chlorogenic acid inhibits osteosarcoma carcinogenesis via suppressing the STAT3/Snail pathway. Chlorogenic acid 0-16 snail family transcriptional repressor 1 Homo sapiens 80-85 30802614-4 2019 Results indicate that SOL at the concentration range from 25 to 100 mug/mL and its main components, chlorogenic acid, caffeic acid (25-100 muM) significantly reduced the pro-inflammatory cytokine IL-1beta, IL-6, TNF-alpha, attenuated iNOS and COX-2 expression in LPS-stimulated Macrophages. Chlorogenic acid 100-116 interleukin 1 beta Mus musculus 196-204 30802614-4 2019 Results indicate that SOL at the concentration range from 25 to 100 mug/mL and its main components, chlorogenic acid, caffeic acid (25-100 muM) significantly reduced the pro-inflammatory cytokine IL-1beta, IL-6, TNF-alpha, attenuated iNOS and COX-2 expression in LPS-stimulated Macrophages. Chlorogenic acid 100-116 interleukin 6 Mus musculus 206-210 30802614-4 2019 Results indicate that SOL at the concentration range from 25 to 100 mug/mL and its main components, chlorogenic acid, caffeic acid (25-100 muM) significantly reduced the pro-inflammatory cytokine IL-1beta, IL-6, TNF-alpha, attenuated iNOS and COX-2 expression in LPS-stimulated Macrophages. Chlorogenic acid 100-116 tumor necrosis factor Mus musculus 212-221 30802614-4 2019 Results indicate that SOL at the concentration range from 25 to 100 mug/mL and its main components, chlorogenic acid, caffeic acid (25-100 muM) significantly reduced the pro-inflammatory cytokine IL-1beta, IL-6, TNF-alpha, attenuated iNOS and COX-2 expression in LPS-stimulated Macrophages. Chlorogenic acid 100-116 nitric oxide synthase 2, inducible Mus musculus 234-238 30802614-4 2019 Results indicate that SOL at the concentration range from 25 to 100 mug/mL and its main components, chlorogenic acid, caffeic acid (25-100 muM) significantly reduced the pro-inflammatory cytokine IL-1beta, IL-6, TNF-alpha, attenuated iNOS and COX-2 expression in LPS-stimulated Macrophages. Chlorogenic acid 100-116 prostaglandin-endoperoxide synthase 2 Mus musculus 243-248 31240234-0 2019 Chlorogenic Acid Inhibits BAFF Expression in Collagen-Induced Arthritis and Human Synoviocyte MH7A Cells by Modulating the Activation of the NF-kappaB Signaling Pathway. Chlorogenic acid 0-16 TNF superfamily member 13b Homo sapiens 26-30 30914352-0 2019 Chlorogenic acid and caffeic acid from Sonchus oleraceus Linn synergistically attenuate insulin resistance and modulate glucose uptake in HepG2 cells. Chlorogenic acid 0-16 insulin Homo sapiens 88-95 31139644-0 2019 Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway. Chlorogenic acid 0-16 mitogen-activated protein kinase 1 Mus musculus 99-102 31139644-0 2019 Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway. Chlorogenic acid 0-16 mitogen-activated protein kinase 8 Mus musculus 103-106 31139644-4 2019 The relationship between chlorogenic acid and MAPK/ERK/JNK signaling pathway was explored by adding ERK inhibitor. Chlorogenic acid 25-41 mitogen-activated protein kinase 1 Mus musculus 51-54 31139644-4 2019 The relationship between chlorogenic acid and MAPK/ERK/JNK signaling pathway was explored by adding ERK inhibitor. Chlorogenic acid 25-41 mitogen-activated protein kinase 8 Mus musculus 55-58 31139644-4 2019 The relationship between chlorogenic acid and MAPK/ERK/JNK signaling pathway was explored by adding ERK inhibitor. Chlorogenic acid 25-41 mitogen-activated protein kinase 1 Mus musculus 100-103 31139644-6 2019 Chlorogenic acid reduces DSS-induced colonic mucosal damage, inhibits DSS-induced inflammation, oxidative stress, and apoptosis in colon, and reduces ERK1/2, p -ERK, p38, p-p38, JNK, and p-JNK protein expression. Chlorogenic acid 0-16 mitogen-activated protein kinase 3 Mus musculus 150-156 31139644-6 2019 Chlorogenic acid reduces DSS-induced colonic mucosal damage, inhibits DSS-induced inflammation, oxidative stress, and apoptosis in colon, and reduces ERK1/2, p -ERK, p38, p-p38, JNK, and p-JNK protein expression. Chlorogenic acid 0-16 mitogen-activated protein kinase 1 Mus musculus 150-153 31139644-6 2019 Chlorogenic acid reduces DSS-induced colonic mucosal damage, inhibits DSS-induced inflammation, oxidative stress, and apoptosis in colon, and reduces ERK1/2, p -ERK, p38, p-p38, JNK, and p-JNK protein expression. Chlorogenic acid 0-16 mitogen-activated protein kinase 14 Mus musculus 166-169 31139644-6 2019 Chlorogenic acid reduces DSS-induced colonic mucosal damage, inhibits DSS-induced inflammation, oxidative stress, and apoptosis in colon, and reduces ERK1/2, p -ERK, p38, p-p38, JNK, and p-JNK protein expression. Chlorogenic acid 0-16 mitogen-activated protein kinase 14 Mus musculus 173-176 31139644-6 2019 Chlorogenic acid reduces DSS-induced colonic mucosal damage, inhibits DSS-induced inflammation, oxidative stress, and apoptosis in colon, and reduces ERK1/2, p -ERK, p38, p-p38, JNK, and p-JNK protein expression. Chlorogenic acid 0-16 mitogen-activated protein kinase 8 Mus musculus 178-181 31139644-6 2019 Chlorogenic acid reduces DSS-induced colonic mucosal damage, inhibits DSS-induced inflammation, oxidative stress, and apoptosis in colon, and reduces ERK1/2, p -ERK, p38, p-p38, JNK, and p-JNK protein expression. Chlorogenic acid 0-16 mitogen-activated protein kinase 8 Mus musculus 189-192 31139644-7 2019 ERK inhibitor U0126 reversed the protective effect of chlorogenic acid on colon tissue. Chlorogenic acid 54-70 mitogen-activated protein kinase 1 Mus musculus 0-3 31139644-8 2019 Conclusion: Chlorogenic acid can alleviate DSS-induced ulcerative colitis in mice, which can significantly reduce tissue inflammation and apoptosis, and its mechanism is related to the MAPK/ERK/JNK signaling pathway. Chlorogenic acid 12-28 mitogen-activated protein kinase 1 Mus musculus 190-193 31139644-8 2019 Conclusion: Chlorogenic acid can alleviate DSS-induced ulcerative colitis in mice, which can significantly reduce tissue inflammation and apoptosis, and its mechanism is related to the MAPK/ERK/JNK signaling pathway. Chlorogenic acid 12-28 mitogen-activated protein kinase 8 Mus musculus 194-197 31240234-0 2019 Chlorogenic Acid Inhibits BAFF Expression in Collagen-Induced Arthritis and Human Synoviocyte MH7A Cells by Modulating the Activation of the NF-kappaB Signaling Pathway. Chlorogenic acid 0-16 nuclear factor kappa B subunit 1 Homo sapiens 141-150 30657151-6 2019 CGA significantly inhibited Pb-induced increase of cytoplasmic NF-kappaB, Bax, cytochrome C, and caspase-9 protein expressions. Chlorogenic acid 0-3 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 63-72 30976294-10 2019 Four compounds including chlorogenic acid, quercetin-3-O-glucuronide, isoquercetin, and quercetin were identified as alpha-glucosidase inhibitors. Chlorogenic acid 25-41 sucrase-isomaltase Homo sapiens 117-134 30458280-18 2019 Furthermore, molecular docking reveals that rutin and chlorogenic acid effectively act as FXR agonists. Chlorogenic acid 54-70 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 90-93 30657151-6 2019 CGA significantly inhibited Pb-induced increase of cytoplasmic NF-kappaB, Bax, cytochrome C, and caspase-9 protein expressions. Chlorogenic acid 0-3 BCL2-associated X protein Mus musculus 74-77 30657151-6 2019 CGA significantly inhibited Pb-induced increase of cytoplasmic NF-kappaB, Bax, cytochrome C, and caspase-9 protein expressions. Chlorogenic acid 0-3 caspase 9 Mus musculus 97-106 30529121-2 2019 In this study, the polyphenols from H. serotina (HSP) were mainly composed by caffeic acid dimer, (-)-epicatechin-3-(3"-o-methyl)-gallic acid dimer, quercetin-acetyl-rutinoside hexoside, (-)-epigallocatechin derivatives, rutin derivatives, catechin trimer and 3-caffeoylquinic acid. Chlorogenic acid 260-281 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 49-52 30547263-6 2019 However, in the absence of LPS, IL-6 secretion was significantly increased in response to 2 microM of either cyanidin or chlorogenic acid (both p < 0.0001), as well as the combination treatment (p < 0.01). Chlorogenic acid 121-137 interleukin 6 Homo sapiens 32-36 30626086-6 2019 Treatment with major polyphenols of PN3, including catechin, chlorogenic acid, caffeic acid, and p-coumaric acid, also improved AA + iron-mediated oxidative stress and, thus, improved cell viability. Chlorogenic acid 61-77 sodium voltage-gated channel alpha subunit 10 Homo sapiens 36-39 30428426-0 2019 Chlorogenic acid protects against aluminum toxicity via MAPK/Akt signaling pathway in murine RAW264.7 macrophages. Chlorogenic acid 0-16 mitogen-activated protein kinase 1 Mus musculus 56-60 30399581-6 2019 CAA and CHA significantly (P < 0.05) reduced SBP and HR, activity of ACE, AChE, BChE and arginase in the treated hypertensive rats compared with cyclosporine induced-hypertensive rats. Chlorogenic acid 8-11 angiotensin I converting enzyme Rattus norvegicus 72-75 30399581-6 2019 CAA and CHA significantly (P < 0.05) reduced SBP and HR, activity of ACE, AChE, BChE and arginase in the treated hypertensive rats compared with cyclosporine induced-hypertensive rats. Chlorogenic acid 8-11 acetylcholinesterase Rattus norvegicus 77-81 30428426-0 2019 Chlorogenic acid protects against aluminum toxicity via MAPK/Akt signaling pathway in murine RAW264.7 macrophages. Chlorogenic acid 0-16 thymoma viral proto-oncogene 1 Mus musculus 61-64 30627576-0 2018 Chlorogenic Acid Functions as a Novel Agonist of PPARgamma2 during the Differentiation of Mouse 3T3-L1 Preadipocytes. Chlorogenic acid 0-16 peroxisome proliferator activated receptor gamma Mus musculus 49-59 30583487-4 2018 In particular, chlorogenic acid had a predicted binding energy comparable or even better than that of some known chymase inhibitors, interacted stably with key amino acids in the chymase active site, and appeared to be more selective for chymase than other serine proteases. Chlorogenic acid 15-31 chymase 1 Homo sapiens 113-120 30583487-4 2018 In particular, chlorogenic acid had a predicted binding energy comparable or even better than that of some known chymase inhibitors, interacted stably with key amino acids in the chymase active site, and appeared to be more selective for chymase than other serine proteases. Chlorogenic acid 15-31 chymase 1 Homo sapiens 179-186 30583487-4 2018 In particular, chlorogenic acid had a predicted binding energy comparable or even better than that of some known chymase inhibitors, interacted stably with key amino acids in the chymase active site, and appeared to be more selective for chymase than other serine proteases. Chlorogenic acid 15-31 chymase 1 Homo sapiens 179-186 30583487-5 2018 Therefore, chlorogenic acid is a promising starting point for developing new chymase inhibitors. Chlorogenic acid 11-27 chymase 1 Homo sapiens 77-84 30518116-0 2018 Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity. Chlorogenic acid 0-16 C-X-C motif chemokine ligand 8 Homo sapiens 41-54 30518116-0 2018 Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity. Chlorogenic acid 0-16 C-X-C motif chemokine ligand 8 Homo sapiens 56-60 30518116-0 2018 Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity. Chlorogenic acid 0-16 mitogen-activated protein kinase 14 Homo sapiens 122-125 30518116-0 2018 Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity. Chlorogenic acid 18-21 C-X-C motif chemokine ligand 8 Homo sapiens 41-54 30518116-0 2018 Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity. Chlorogenic acid 18-21 C-X-C motif chemokine ligand 8 Homo sapiens 56-60 30518116-0 2018 Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity. Chlorogenic acid 18-21 mitogen-activated protein kinase 14 Homo sapiens 122-125 30144352-6 2018 Pyrocatechol, a strong antioxidant known as catechol or 1,2-dihydroxybenzene, produced from chlorogenic acid during roasting, also reduces BACE1 expression by activation of proteasomal activity. Chlorogenic acid 92-108 beta-secretase 1 Homo sapiens 139-144 30381211-0 2018 Novel aldose reductase inhibitory and antioxidant chlorogenic acid derivatives obtained by heat treatment of chlorogenic acid and amino acids. Chlorogenic acid 50-66 aldo-keto reductase family 1 member B Homo sapiens 6-22 30381211-0 2018 Novel aldose reductase inhibitory and antioxidant chlorogenic acid derivatives obtained by heat treatment of chlorogenic acid and amino acids. Chlorogenic acid 109-125 aldo-keto reductase family 1 member B Homo sapiens 6-22 30165128-4 2018 Furthermore, ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression. Chlorogenic acid 13-16 mitogen-activated protein kinase 3 Mus musculus 76-122 30165128-4 2018 Furthermore, ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression. Chlorogenic acid 13-16 mitogen-activated protein kinase 3 Mus musculus 124-130 30165128-4 2018 Furthermore, ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression. Chlorogenic acid 13-16 mitogen-activated protein kinase 8 Mus musculus 133-165 30165128-4 2018 Furthermore, ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression. Chlorogenic acid 13-16 mitogen-activated protein kinase 8 Mus musculus 167-173 30165128-4 2018 Furthermore, ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression. Chlorogenic acid 13-16 thymoma viral proto-oncogene 1 Mus musculus 176-179 30165128-4 2018 Furthermore, ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression. Chlorogenic acid 13-16 signal transducer and activator of transcription 3 Mus musculus 184-234 30165128-4 2018 Furthermore, ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression. Chlorogenic acid 13-16 signal transducer and activator of transcription 3 Mus musculus 236-241 30165128-4 2018 Furthermore, ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression. Chlorogenic acid 13-16 phosphatase and tensin homolog Mus musculus 308-312 30165128-6 2018 Induction of apoptosis and oxidative stress was attenuated in a dose-dependent manner by suppressing Bax, caspase-8, caspase-9 and heme oxygenase-1 (HO-1) protein expression in mice administrated with ChA. Chlorogenic acid 201-204 BCL2-associated X protein Mus musculus 101-104 30165128-6 2018 Induction of apoptosis and oxidative stress was attenuated in a dose-dependent manner by suppressing Bax, caspase-8, caspase-9 and heme oxygenase-1 (HO-1) protein expression in mice administrated with ChA. Chlorogenic acid 201-204 heme oxygenase 1 Mus musculus 131-147 30165128-6 2018 Induction of apoptosis and oxidative stress was attenuated in a dose-dependent manner by suppressing Bax, caspase-8, caspase-9 and heme oxygenase-1 (HO-1) protein expression in mice administrated with ChA. Chlorogenic acid 201-204 heme oxygenase 1 Mus musculus 149-153 30259744-0 2018 Amelioration of Oxidative Stress in Caco-2 Cells Treated with Pro-inflammatory Proteins by Chlorogenic Acid Isomers via Activation of the Nrf2-Keap1-ARE-Signaling Pathway. Chlorogenic acid 91-107 NFE2 like bZIP transcription factor 2 Homo sapiens 138-142 30259744-0 2018 Amelioration of Oxidative Stress in Caco-2 Cells Treated with Pro-inflammatory Proteins by Chlorogenic Acid Isomers via Activation of the Nrf2-Keap1-ARE-Signaling Pathway. Chlorogenic acid 91-107 kelch like ECH associated protein 1 Homo sapiens 143-148 29980959-5 2018 Oxidation of the catecholic phenolic compound chlorogenic acid by PPO enhances the lethality of the insect-killing bacterial pathogen, Bacillus thuringiensis var. Chlorogenic acid 46-62 polyphenol oxidase B, chloroplastic Solanum lycopersicum 66-69 30233784-4 2018 The IGF-I-stimulated osteoblast migration, evaluated by Transwell cell migration and wound-healing assays, was inhibited by EGCG but not chlorogenic acid. Chlorogenic acid 137-153 insulin like growth factor 1 Homo sapiens 4-9 30257424-1 2018 Chlorogenic acid (CGA) is a very common dietary polyphenolic compound. Chlorogenic acid 0-16 chromogranin A Homo sapiens 18-21 29786770-4 2018 Both the tested extracts showed anticancer properties and the better results were observed for AtPAP1 with transcriptional factor root extract; this effect could be ascribed to the presence of higher condensed phenolic acids such as neochlorogenic acid, chlorogenic acids, ferulic acid, caffeic acid and p-coumaric acid. Chlorogenic acid 254-271 phosphatidic acid phosphatase 1 Arabidopsis thaliana 95-101 30249058-0 2018 Chlorogenic Acid Targeting of the AKT PH Domain Activates AKT/GSK3beta/FOXO1 Signaling and Improves Glucose Metabolism. Chlorogenic acid 0-16 AKT serine/threonine kinase 1 Homo sapiens 34-37 30249058-0 2018 Chlorogenic Acid Targeting of the AKT PH Domain Activates AKT/GSK3beta/FOXO1 Signaling and Improves Glucose Metabolism. Chlorogenic acid 0-16 AKT serine/threonine kinase 1 Homo sapiens 58-61 30249058-0 2018 Chlorogenic Acid Targeting of the AKT PH Domain Activates AKT/GSK3beta/FOXO1 Signaling and Improves Glucose Metabolism. Chlorogenic acid 0-16 glycogen synthase kinase 3 beta Homo sapiens 62-70 30249058-0 2018 Chlorogenic Acid Targeting of the AKT PH Domain Activates AKT/GSK3beta/FOXO1 Signaling and Improves Glucose Metabolism. Chlorogenic acid 0-16 forkhead box O1 Homo sapiens 71-76 30127826-6 2018 The best inhibitory activity against COX-1 (71.77% and 77.04%, respectively) and COX-2 ( 64.14% and 72.23%, respectively) were shown by H. thymbrifolium and H. spectabile, which may be due to their richest chlorogenic acid content (0.29576% and 0.23567%, respectively). Chlorogenic acid 206-222 cytochrome c oxidase subunit 8A Homo sapiens 37-40 30127826-6 2018 The best inhibitory activity against COX-1 (71.77% and 77.04%, respectively) and COX-2 ( 64.14% and 72.23%, respectively) were shown by H. thymbrifolium and H. spectabile, which may be due to their richest chlorogenic acid content (0.29576% and 0.23567%, respectively). Chlorogenic acid 206-222 cytochrome c oxidase subunit 8A Homo sapiens 81-84 29606470-1 2018 To help produce hypoallergenic food, this study investigated reducing the allergenicity and improving the functional properties of bovine beta-lactoglobulin (betaLG) by covalent conjugation with (-)-epigallo-catechin 3-gallate (EGCG) and chlorogenic acid (CA). Chlorogenic acid 238-254 beta-lactoglobulin Bos taurus 138-156 29803450-0 2018 Evaluation of butyrylcholinesterase inhibitory activity by chlorogenic acids and coffee extracts assed in ITC and docking simulation models. Chlorogenic acid 59-76 butyrylcholinesterase Homo sapiens 14-35 29803450-13 2018 After introducing acetylcholine into the model system, the strongest ability to inhibit hydrolytic activity of BChE was again observed for ferulic acid and additionally for 3-caffeoylquinic acid, and among coffee brews the most active were light roasted Arabica and green Robusta. Chlorogenic acid 173-194 butyrylcholinesterase Homo sapiens 111-115 29656453-0 2018 Chlorogenic Acid Protects Against oxLDL-Induced Oxidative Damage and Mitochondrial Dysfunction by Modulating SIRT1 in Endothelial Cells. Chlorogenic acid 0-16 sirtuin 1 Homo sapiens 109-114 29872017-0 2018 Chlorogenic acid alleviates autophagy and insulin resistance by suppressing JNK pathway in a rat model of nonalcoholic fatty liver disease. Chlorogenic acid 0-16 mitogen-activated protein kinase 8 Rattus norvegicus 76-79 29477910-0 2018 Chlorogenic acid attenuates glucotoxicity in H9c2 cells via inhibition of glycation and PKC alpha upregulation and safeguarding innate antioxidant status. Chlorogenic acid 0-16 protein kinase C, alpha Rattus norvegicus 88-97 29783729-8 2018 The mechanisms underlying the positive effects of combining CGA and Regorafenib were also addressed and an increased inhibition of MAPK (mitogen-activated protein kinase)and PI3K/Akt/mTORC (phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling was observed. Chlorogenic acid 60-63 AKT serine/threonine kinase 1 Homo sapiens 179-182 29783729-8 2018 The mechanisms underlying the positive effects of combining CGA and Regorafenib were also addressed and an increased inhibition of MAPK (mitogen-activated protein kinase)and PI3K/Akt/mTORC (phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling was observed. Chlorogenic acid 60-63 AKT serine/threonine kinase 1 Homo sapiens 227-230 29783729-8 2018 The mechanisms underlying the positive effects of combining CGA and Regorafenib were also addressed and an increased inhibition of MAPK (mitogen-activated protein kinase)and PI3K/Akt/mTORC (phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling was observed. Chlorogenic acid 60-63 mechanistic target of rapamycin kinase Homo sapiens 239-268 29783729-8 2018 The mechanisms underlying the positive effects of combining CGA and Regorafenib were also addressed and an increased inhibition of MAPK (mitogen-activated protein kinase)and PI3K/Akt/mTORC (phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling was observed. Chlorogenic acid 60-63 mechanistic target of rapamycin kinase Homo sapiens 183-187 29261010-0 2018 Effect of Chlorogenic Acid Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance. Chlorogenic acid 10-26 insulin Homo sapiens 63-70 29261010-0 2018 Effect of Chlorogenic Acid Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance. Chlorogenic acid 10-26 insulin Homo sapiens 86-93 29261010-2 2018 The aim of this study was to evaluate the effect of chlorogenic acid administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance (IGT). Chlorogenic acid 52-68 insulin Homo sapiens 105-112 29261010-9 2018 In conclusion, chlorogenic acid administration in patients with IGT decreased FPG and insulin secretion, while increasing insulin sensitivity and improving both anthropometric evaluations and the lipid profile. Chlorogenic acid 15-31 insulin Homo sapiens 86-93 29398668-4 2018 The NJ extract and chlorogenic acid, a major component of NJ, inhibited Abeta-induced cell death in SH-SY5Y cells. Chlorogenic acid 19-35 amyloid beta precursor protein Homo sapiens 72-77 29332828-9 2018 Using the UPLC-MS/MS data, peaks P14, P19, P21, and P30 were respectively identified as chlorogenic acid, quercetin, kaempferol, and isorhamnetin, and then the results were confirmed through comparison with the standards and other references. Chlorogenic acid 88-104 centromere protein V Homo sapiens 52-55 28875417-5 2018 Polymerase chain reaction (PCR) showed that treatment of cells with chlorogenic acid reduced the expression of BCL2 but increased that of both BAX and CASP3. Chlorogenic acid 68-84 BCL2 apoptosis regulator Homo sapiens 111-115 28875417-5 2018 Polymerase chain reaction (PCR) showed that treatment of cells with chlorogenic acid reduced the expression of BCL2 but increased that of both BAX and CASP3. Chlorogenic acid 68-84 BCL2 associated X, apoptosis regulator Homo sapiens 143-146 28875417-5 2018 Polymerase chain reaction (PCR) showed that treatment of cells with chlorogenic acid reduced the expression of BCL2 but increased that of both BAX and CASP3. Chlorogenic acid 68-84 caspase 3 Homo sapiens 151-156 28875417-6 2018 Chlorogenic acid enhanced annexin V expression as measured using fluorescently labeled annexin V. Chlorogenic acid 0-16 annexin A5 Homo sapiens 26-35 28875417-6 2018 Chlorogenic acid enhanced annexin V expression as measured using fluorescently labeled annexin V. Chlorogenic acid 0-16 annexin A5 Homo sapiens 87-96 28875417-7 2018 Chlorogenic acid also induced p38 MAPK and JNK gene expression. Chlorogenic acid 0-16 mitogen-activated protein kinase 14 Homo sapiens 30-33 28875417-7 2018 Chlorogenic acid also induced p38 MAPK and JNK gene expression. Chlorogenic acid 0-16 mitogen-activated protein kinase 8 Homo sapiens 43-46 28875417-9 2018 Chlorogenic acid reduced gene expression levels of stem cell-associated markers NANOG, POU5F1, and SOX2. Chlorogenic acid 0-16 Nanog homeobox Homo sapiens 80-85 28875417-9 2018 Chlorogenic acid reduced gene expression levels of stem cell-associated markers NANOG, POU5F1, and SOX2. Chlorogenic acid 0-16 POU class 5 homeobox 1 Homo sapiens 87-93 28875417-9 2018 Chlorogenic acid reduced gene expression levels of stem cell-associated markers NANOG, POU5F1, and SOX2. Chlorogenic acid 0-16 SRY-box transcription factor 2 Homo sapiens 99-103 28875417-10 2018 Together these results indicate that chlorogenic acid affects the expression of apoptosis-related genes that are part of oxidative stress and p38 MAP-dependent pathways, as well as genes encoding stem cell markers. Chlorogenic acid 37-53 mitogen-activated protein kinase 14 Homo sapiens 142-145 29332828-9 2018 Using the UPLC-MS/MS data, peaks P14, P19, P21, and P30 were respectively identified as chlorogenic acid, quercetin, kaempferol, and isorhamnetin, and then the results were confirmed through comparison with the standards and other references. Chlorogenic acid 88-104 ribonuclease P/MRP subunit p14 Homo sapiens 33-36 29332828-9 2018 Using the UPLC-MS/MS data, peaks P14, P19, P21, and P30 were respectively identified as chlorogenic acid, quercetin, kaempferol, and isorhamnetin, and then the results were confirmed through comparison with the standards and other references. Chlorogenic acid 88-104 interleukin 23 subunit alpha Homo sapiens 38-41 29146180-0 2018 Chlorogenic acid attenuates diabetic retinopathy by reducing VEGF expression and inhibiting VEGF-mediated retinal neoangiogenesis. Chlorogenic acid 0-16 vascular endothelial growth factor A Mus musculus 61-65 29332828-9 2018 Using the UPLC-MS/MS data, peaks P14, P19, P21, and P30 were respectively identified as chlorogenic acid, quercetin, kaempferol, and isorhamnetin, and then the results were confirmed through comparison with the standards and other references. Chlorogenic acid 88-104 H3 histone pseudogene 16 Homo sapiens 43-46 29360226-0 2018 Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1-mediated deacetylation of FXR and PGC-1alpha. Chlorogenic acid 70-86 sirtuin 1 Rattus norvegicus 169-174 29360226-0 2018 Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1-mediated deacetylation of FXR and PGC-1alpha. Chlorogenic acid 70-86 PPARG coactivator 1 alpha Rattus norvegicus 209-219 29146180-0 2018 Chlorogenic acid attenuates diabetic retinopathy by reducing VEGF expression and inhibiting VEGF-mediated retinal neoangiogenesis. Chlorogenic acid 0-16 vascular endothelial growth factor A Mus musculus 92-96 29128856-0 2018 Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury. Chlorogenic acid 114-130 NFE2 like bZIP transcription factor 2 Rattus norvegicus 14-18 28489956-0 2018 The Role of Chlorogenic Acid Supplementation in Anemia and Mineral Disturbances Induced by 4-Tert-Octylphenol Toxicity. Chlorogenic acid 12-28 telomerase reverse transcriptase Rattus norvegicus 93-97 28489956-12 2018 In conclusion, chlorogenic acid protects from anemia and mineral disturbances in 4-tert-octylphenol toxicity by ameliorating oxidative stress and apoptosis. Chlorogenic acid 15-31 telomerase reverse transcriptase Rattus norvegicus 83-87 29161661-0 2018 Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-kB pathways. Chlorogenic acid 0-16 NFE2 like bZIP transcription factor 2 Rattus norvegicus 121-125 29161661-0 2018 Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-kB pathways. Chlorogenic acid 0-16 heme oxygenase 1 Rattus norvegicus 126-130 29161661-0 2018 Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-kB pathways. Chlorogenic acid 0-16 nuclear factor kappa B subunit 1 Rattus norvegicus 135-140 29128856-0 2018 Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury. Chlorogenic acid 114-130 NLR family, pyrin domain containing 3 Rattus norvegicus 45-50 29115619-0 2018 Administration of chlorogenic acid alleviates spinal cord injury via TLR4/NF-kappaB and p38 signaling pathway anti-inflammatory activity. Chlorogenic acid 18-34 toll-like receptor 4 Rattus norvegicus 69-73 29115619-0 2018 Administration of chlorogenic acid alleviates spinal cord injury via TLR4/NF-kappaB and p38 signaling pathway anti-inflammatory activity. Chlorogenic acid 18-34 mitogen activated protein kinase 14 Rattus norvegicus 88-91 29115619-2 2018 The present study demonstrated that administration of chlorogenic acid alleviated spinal cord injury (SCI) via anti-inflammatory activity mediated by nuclear factor (NF)-kappaB and p38 signaling pathways. Chlorogenic acid 54-70 mitogen activated protein kinase 14 Rattus norvegicus 181-184 29115619-6 2018 In addition, chlorogenic acid suppressed SCI-induced inflammatory activity, inducible nitric oxide synthase activity and cyclooxygenase-2 protein expression in the SCI rat. Chlorogenic acid 13-29 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 121-137 29115619-7 2018 Furthermore, chlorogenic acid suppressed Toll like receptor (TLR)-4/myeloid differentiation primary response 88 (MyD88)/NF-kappaB/IkappaB signaling pathways and downregulated p38 mitogen activated protein kinase protein expression in SCI rats. Chlorogenic acid 13-29 toll-like receptor 4 Rattus norvegicus 41-67 29115619-7 2018 Furthermore, chlorogenic acid suppressed Toll like receptor (TLR)-4/myeloid differentiation primary response 88 (MyD88)/NF-kappaB/IkappaB signaling pathways and downregulated p38 mitogen activated protein kinase protein expression in SCI rats. Chlorogenic acid 13-29 MYD88, innate immune signal transduction adaptor Rattus norvegicus 113-118 29115619-7 2018 Furthermore, chlorogenic acid suppressed Toll like receptor (TLR)-4/myeloid differentiation primary response 88 (MyD88)/NF-kappaB/IkappaB signaling pathways and downregulated p38 mitogen activated protein kinase protein expression in SCI rats. Chlorogenic acid 13-29 mitogen activated protein kinase 14 Rattus norvegicus 175-178 29115619-8 2018 The findings suggest that administration of chlorogenic acid alleviates SCI via anti-inflammatory activity mediated by TLR4/MyD88/NF-kappaB and p38 signaling pathways. Chlorogenic acid 44-60 toll-like receptor 4 Rattus norvegicus 119-123 29115619-8 2018 The findings suggest that administration of chlorogenic acid alleviates SCI via anti-inflammatory activity mediated by TLR4/MyD88/NF-kappaB and p38 signaling pathways. Chlorogenic acid 44-60 MYD88, innate immune signal transduction adaptor Rattus norvegicus 124-129 29115619-8 2018 The findings suggest that administration of chlorogenic acid alleviates SCI via anti-inflammatory activity mediated by TLR4/MyD88/NF-kappaB and p38 signaling pathways. Chlorogenic acid 44-60 mitogen activated protein kinase 14 Rattus norvegicus 144-147 28111996-7 2017 In this study, all phenolic acids except for chlorogenic acid and p-coumaric acid showed non-competitive inhibition effects on rat kidney AR. Chlorogenic acid 45-61 aldo-keto reductase family 1 member B1 Rattus norvegicus 138-140 29311932-0 2017 Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-beta1/Smad7 Signaling Pathway in Vitro and in Vivo. Chlorogenic acid 0-16 microRNA 21 Homo sapiens 57-63 29311932-0 2017 Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-beta1/Smad7 Signaling Pathway in Vitro and in Vivo. Chlorogenic acid 0-16 transforming growth factor beta 1 Homo sapiens 74-83 29311932-0 2017 Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-beta1/Smad7 Signaling Pathway in Vitro and in Vivo. Chlorogenic acid 0-16 SMAD family member 7 Homo sapiens 84-89 28964634-0 2017 Synthesis, biological evaluation, and metabolic stability of chlorogenic acid derivatives possessing thiazole as potent inhibitors of alpha-MSH-stimulated melanogenesis. Chlorogenic acid 61-77 proopiomelanocortin Homo sapiens 134-143 28990048-0 2017 Chlorogenic acid suppresses lipopolysaccharide-induced nitric oxide and interleukin-1beta expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells. Chlorogenic acid 0-16 interleukin 1 beta Mus musculus 72-89 28990048-0 2017 Chlorogenic acid suppresses lipopolysaccharide-induced nitric oxide and interleukin-1beta expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells. Chlorogenic acid 0-16 Janus kinase 2 Mus musculus 115-119 28990048-0 2017 Chlorogenic acid suppresses lipopolysaccharide-induced nitric oxide and interleukin-1beta expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells. Chlorogenic acid 0-16 signal transducer and activator of transcription 3 Mus musculus 120-125 28759754-0 2017 Potential of the chlorogenic acid as multitarget agent: Insulin-secretagogue and PPAR alpha/gamma dual agonist. Chlorogenic acid 17-33 peroxisome proliferator activated receptor alpha Rattus norvegicus 81-91 28677092-9 2017 Expressions of collagen I, alpha-SMA, GRP78, and CHOP were significantly inhibited by chlorogenic acid in dose-dependent manner. Chlorogenic acid 86-102 heat shock protein 5 Mus musculus 38-43 28450000-5 2017 Chlorogenic acid, 3,5-di-O-caffeoylquinic acid, and 1,3,5-tri-O-caffeoylquinic acid were identified as the antioxidants and aldose reductase inhibitors; apigenin was identified as the antioxidant. Chlorogenic acid 0-16 aldo-keto reductase family 1 member B Homo sapiens 124-140 28677092-10 2017 Similarly, decreasing levels of cleaved caspase-12, caspase-9, caspase-3 and increasing level of uncleaved PARP were observed in chlorogenic acid groups compared with those in the fibrosis group both in vivo and in vitro. Chlorogenic acid 129-145 caspase 12 Mus musculus 40-50 28677092-10 2017 Similarly, decreasing levels of cleaved caspase-12, caspase-9, caspase-3 and increasing level of uncleaved PARP were observed in chlorogenic acid groups compared with those in the fibrosis group both in vivo and in vitro. Chlorogenic acid 129-145 caspase 9 Mus musculus 52-61 28677092-10 2017 Similarly, decreasing levels of cleaved caspase-12, caspase-9, caspase-3 and increasing level of uncleaved PARP were observed in chlorogenic acid groups compared with those in the fibrosis group both in vivo and in vitro. Chlorogenic acid 129-145 caspase 3 Mus musculus 63-72 28677092-10 2017 Similarly, decreasing levels of cleaved caspase-12, caspase-9, caspase-3 and increasing level of uncleaved PARP were observed in chlorogenic acid groups compared with those in the fibrosis group both in vivo and in vitro. Chlorogenic acid 129-145 poly (ADP-ribose) polymerase family, member 1 Mus musculus 107-111 28677092-11 2017 Chlorogenic acid could also significantly down-regulate the level of phosphorylation of PERK and cleaved ATF-6 in vivo study. Chlorogenic acid 0-16 eukaryotic translation initiation factor 2 alpha kinase 3 Mus musculus 88-92 28677092-11 2017 Chlorogenic acid could also significantly down-regulate the level of phosphorylation of PERK and cleaved ATF-6 in vivo study. Chlorogenic acid 0-16 activating transcription factor 6 Mus musculus 105-110 28677092-12 2017 Moreover, MTT assay demonstrated chlorogenic acid could enhance proliferation of RLE-6TN cells induced by TGFbeta1 in vitro. Chlorogenic acid 33-49 transforming growth factor, beta 1 Rattus norvegicus 106-114 28855037-0 2017 [Mechanism of Chlorogenic Acid in Apoptotic Regulation through Notch1 : Pathway in Non-small Cell Lung Carcinoma in Animal Level]. Chlorogenic acid 14-30 notch receptor 1 Homo sapiens 63-69 28855037-1 2017 BACKGROUND: It has been proven that chlorogenic acids can produce anticancer effects by regulating cell cycle, inducing apoptosis, inhibiting cell growth, Notch signaling pathways are closely related to many human tumors. Chlorogenic acid 36-53 notch receptor 1 Homo sapiens 155-160 28855037-2 2017 The aim of this study is to study the mechanism of chlorogenic acid on apoptosis of non-small lung cancer through Notch1 pathway in animal level, and hope to provide theory basis on clinical treatment and research aimed at targeting Notch1 signaling in non-small cell carcinoma (NSCLC). Chlorogenic acid 51-67 notch receptor 1 Homo sapiens 114-120 28855037-2 2017 The aim of this study is to study the mechanism of chlorogenic acid on apoptosis of non-small lung cancer through Notch1 pathway in animal level, and hope to provide theory basis on clinical treatment and research aimed at targeting Notch1 signaling in non-small cell carcinoma (NSCLC). Chlorogenic acid 51-67 notch receptor 1 Homo sapiens 233-239 28855037-12 2017 CONCLUSIONS: Chlorogenic acid can regulate theapoptosis of non-small lung cancer through Notch pathway in animal level, which may be associated with the down-regulating the expression of VEGF and Delta4. Chlorogenic acid 13-29 notch receptor 1 Homo sapiens 89-94 28855037-12 2017 CONCLUSIONS: Chlorogenic acid can regulate theapoptosis of non-small lung cancer through Notch pathway in animal level, which may be associated with the down-regulating the expression of VEGF and Delta4. Chlorogenic acid 13-29 vascular endothelial growth factor A Homo sapiens 187-191 28855037-12 2017 CONCLUSIONS: Chlorogenic acid can regulate theapoptosis of non-small lung cancer through Notch pathway in animal level, which may be associated with the down-regulating the expression of VEGF and Delta4. Chlorogenic acid 13-29 delta like canonical Notch ligand 4 Homo sapiens 196-202 28771559-4 2017 Level and enzymatic activity of peroxidase were reduced, while both the protein levels and the enzymatic activities of superoxide dismutase, glutathione reductase, glutathione-s-transferase and monodehydroascorbate reductase were enhanced in nectarine fruit treated with CHA. Chlorogenic acid 271-274 glutathione-disulfide reductase Homo sapiens 141-162 28416373-5 2017 Comparing with benign prostatic hyperplasia model group, the high and medium dose of chlorogenic acid could significantly reduce prostate index and levels of acid phosphatase, prostatic acid phosphatase and typeII5-alpha-reductase (P<0.05 or P<0.01). Chlorogenic acid 85-101 acid phosphatase, prostate Mus musculus 176-202 28771559-4 2017 Level and enzymatic activity of peroxidase were reduced, while both the protein levels and the enzymatic activities of superoxide dismutase, glutathione reductase, glutathione-s-transferase and monodehydroascorbate reductase were enhanced in nectarine fruit treated with CHA. Chlorogenic acid 271-274 glutathione S-transferase kappa 1 Homo sapiens 164-189 28586061-0 2017 Chlorogenic acid prevents inflammatory responses in IL-1beta-stimulated human SW-1353 chondrocytes, a model for osteoarthritis. Chlorogenic acid 0-16 interleukin 1 beta Homo sapiens 52-60 28579891-6 2017 Every chlorogenic acid group with different dosage can significantly reduce the mortality, NDS and cerebral infarction area of rats, and significantly increase the EPO, HIF-1alpha and NGF levels in brain tissue; significantly improve the pathological lesions of hippocampus and cortex in brain tissue. Chlorogenic acid 6-22 erythropoietin Rattus norvegicus 164-167 28407238-0 2017 Quercetin, Hyperin, and Chlorogenic Acid Improve Endothelial Function by Antioxidant, Antiinflammatory, and ACE Inhibitory Effects. Chlorogenic acid 24-40 angiotensin I converting enzyme Homo sapiens 108-111 28674386-3 2017 ChA or CaA could reduce the histopathological changes and liver injury markers, such as alanine transarninase, aspartate aminotransferase, alkaline phosphatase, total bile acid, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol. Chlorogenic acid 0-3 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 111-137 26788968-7 2017 Coffee component(s) responsible for the activation of HIF-1alpha was not major constituents such as caffeine, caffeic acid, chlorogenic acid, and trigonelline, but was found to emerge during roasting process. Chlorogenic acid 124-140 hypoxia inducible factor 1 subunit alpha Homo sapiens 54-64 28661454-7 2017 Moreover, ChA could significantly suppress the secretion of IFNgamma, TNFalpha, and IL-6 and the colonic infiltration of F4/80+ macrophages, CD3+ T cells, and CD177+ neutrophils via inhibition of the active NF-kappaB signaling pathway. Chlorogenic acid 10-13 interferon gamma Mus musculus 60-68 28661454-7 2017 Moreover, ChA could significantly suppress the secretion of IFNgamma, TNFalpha, and IL-6 and the colonic infiltration of F4/80+ macrophages, CD3+ T cells, and CD177+ neutrophils via inhibition of the active NF-kappaB signaling pathway. Chlorogenic acid 10-13 tumor necrosis factor Mus musculus 70-78 28661454-7 2017 Moreover, ChA could significantly suppress the secretion of IFNgamma, TNFalpha, and IL-6 and the colonic infiltration of F4/80+ macrophages, CD3+ T cells, and CD177+ neutrophils via inhibition of the active NF-kappaB signaling pathway. Chlorogenic acid 10-13 interleukin 6 Mus musculus 84-88 28661454-7 2017 Moreover, ChA could significantly suppress the secretion of IFNgamma, TNFalpha, and IL-6 and the colonic infiltration of F4/80+ macrophages, CD3+ T cells, and CD177+ neutrophils via inhibition of the active NF-kappaB signaling pathway. Chlorogenic acid 10-13 adhesion G protein-coupled receptor E1 Mus musculus 121-126 28579891-6 2017 Every chlorogenic acid group with different dosage can significantly reduce the mortality, NDS and cerebral infarction area of rats, and significantly increase the EPO, HIF-1alpha and NGF levels in brain tissue; significantly improve the pathological lesions of hippocampus and cortex in brain tissue. Chlorogenic acid 6-22 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 169-179 27974734-0 2017 Antibiofilm and Anti-beta-Lactamase Activities of Burdock Root Extract and Chlorogenic Acid against Klebsiella pneumoniae. Chlorogenic acid 75-91 beta-lactamase Klebsiella pneumoniae 21-35 28028753-0 2017 Chlorogenic Acid Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting TLR4/NF-kappaB Signal Pathway. Chlorogenic acid 0-16 toll-like receptor 4 Mus musculus 89-93 28028753-0 2017 Chlorogenic Acid Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting TLR4/NF-kappaB Signal Pathway. Chlorogenic acid 0-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 94-103 28420123-5 2017 Likewise, after storage, 3-O-caffeoylquinic acid and 5-O-caffeoylquinic acid increased by 46.7% and 98.2%, respectively in CS1. Chlorogenic acid 25-48 myozenin 2 Homo sapiens 123-126 28393840-0 2017 Antiviral activity of chlorogenic acid against influenza A (H1N1/H3N2) virus and its inhibition of neuraminidase. Chlorogenic acid 22-38 neuraminidase 1 Homo sapiens 99-112 28393840-10 2017 These results demonstrate that CHA acts as a neuraminidase blocker to inhibit influenza A virus both in cellular and animal models. Chlorogenic acid 31-34 neuraminidase 1 Homo sapiens 45-58 28165392-0 2017 Sphingosine Kinase-1 Involves the Inhibitory Action of HIF-1alpha by Chlorogenic Acid in Hypoxic DU145 Cells. Chlorogenic acid 69-85 sphingosine kinase 1 Homo sapiens 0-20 28088700-0 2017 Chlorogenic acid ameliorated concanavalin A-induced hepatitis by suppression of Toll-like receptor 4 signaling in mice. Chlorogenic acid 0-16 toll-like receptor 4 Mus musculus 80-100 28230729-1 2017 Chlorogenic acid (CHA) and caffeic acid (CA) are phenolic compounds found in coffee, which inhibit oxidative stress-induced interleukin (IL)-8 production in intestinal epithelial cells, thereby suppressing serious cellular injury and inflammatory intestinal diseases. Chlorogenic acid 0-16 C-X-C motif chemokine ligand 8 Homo sapiens 124-142 28230729-1 2017 Chlorogenic acid (CHA) and caffeic acid (CA) are phenolic compounds found in coffee, which inhibit oxidative stress-induced interleukin (IL)-8 production in intestinal epithelial cells, thereby suppressing serious cellular injury and inflammatory intestinal diseases. Chlorogenic acid 18-21 C-X-C motif chemokine ligand 8 Homo sapiens 124-142 27704645-4 2017 Chlorogenic acid degraded blood clot and inhibited the enzymatic activity of procoagulant proteases, thrombin, activated factor X (FXa), and activated factor XIII (FXIIIa). Chlorogenic acid 0-16 coagulation factor II Mus musculus 101-109 27704645-5 2017 Chlorogenic acid was found to delay activated partial thromboplastin time, prothrombin time, and thrombin time. Chlorogenic acid 0-16 coagulation factor II Mus musculus 78-86 28122344-0 2017 Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway. Chlorogenic acid 25-41 thymoma viral proto-oncogene 1 Mus musculus 124-127 28122344-0 2017 Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway. Chlorogenic acid 25-41 nuclear factor, erythroid derived 2, like 2 Mus musculus 137-141 28122344-0 2017 Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway. Chlorogenic acid 25-41 heme oxygenase 1 Mus musculus 142-146 28230729-2 2017 Therefore, we investigated the anti-inflammatory mechanism of CHA and CA, both of which inhibited hydrogen peroxide (H2O2)-induced IL-8 transcriptional activity. Chlorogenic acid 62-65 C-X-C motif chemokine ligand 8 Homo sapiens 131-135 28165392-0 2017 Sphingosine Kinase-1 Involves the Inhibitory Action of HIF-1alpha by Chlorogenic Acid in Hypoxic DU145 Cells. Chlorogenic acid 69-85 hypoxia inducible factor 1 subunit alpha Homo sapiens 55-65 28165392-8 2017 Chlorogenic acid (CA) is one of four major compounds of CPE. Chlorogenic acid 0-16 carboxypeptidase E Homo sapiens 56-59 27872076-0 2017 Antischistosomiasis Liver Fibrosis Effects of Chlorogenic Acid through IL-13/miR-21/Smad7 Signaling Interactions In Vivo and In Vitro. Chlorogenic acid 46-62 interleukin 13 Homo sapiens 71-76 28074952-0 2017 Upregulation of caveolin-1 by mulberry leaf extract and its major components, chlorogenic acid derivatives, attenuates alcoholic steatohepatitis via inhibition of oxidative stress. Chlorogenic acid 78-94 caveolin 1, caveolae protein Mus musculus 16-26 27872076-0 2017 Antischistosomiasis Liver Fibrosis Effects of Chlorogenic Acid through IL-13/miR-21/Smad7 Signaling Interactions In Vivo and In Vitro. Chlorogenic acid 46-62 microRNA 21 Homo sapiens 77-83 27872076-0 2017 Antischistosomiasis Liver Fibrosis Effects of Chlorogenic Acid through IL-13/miR-21/Smad7 Signaling Interactions In Vivo and In Vitro. Chlorogenic acid 46-62 SMAD family member 7 Homo sapiens 84-89 27872076-1 2017 This study investigated the antischistosomiasis liver fibrosis effects of chlorogenic acid (CGA) on interleukin 13 (IL-13)/microRNA-21 (miR-21)/Smad7 signaling interactions in the hepatic stellate LX2 cell line and schistosome-infected mice. Chlorogenic acid 74-90 interleukin 13 Homo sapiens 100-114 27872076-1 2017 This study investigated the antischistosomiasis liver fibrosis effects of chlorogenic acid (CGA) on interleukin 13 (IL-13)/microRNA-21 (miR-21)/Smad7 signaling interactions in the hepatic stellate LX2 cell line and schistosome-infected mice. Chlorogenic acid 74-90 interleukin 13 Homo sapiens 116-121 27872076-1 2017 This study investigated the antischistosomiasis liver fibrosis effects of chlorogenic acid (CGA) on interleukin 13 (IL-13)/microRNA-21 (miR-21)/Smad7 signaling interactions in the hepatic stellate LX2 cell line and schistosome-infected mice. Chlorogenic acid 74-90 microRNA 21 Homo sapiens 123-134 27872076-1 2017 This study investigated the antischistosomiasis liver fibrosis effects of chlorogenic acid (CGA) on interleukin 13 (IL-13)/microRNA-21 (miR-21)/Smad7 signaling interactions in the hepatic stellate LX2 cell line and schistosome-infected mice. Chlorogenic acid 74-90 microRNA 21 Homo sapiens 136-142 27872076-1 2017 This study investigated the antischistosomiasis liver fibrosis effects of chlorogenic acid (CGA) on interleukin 13 (IL-13)/microRNA-21 (miR-21)/Smad7 signaling interactions in the hepatic stellate LX2 cell line and schistosome-infected mice. Chlorogenic acid 74-90 SMAD family member 7 Homo sapiens 144-149 28123461-5 2017 Intravenous injection of high-dose ChA or CA (7 mg/kg) markedly increased the peroxide production in the venular walls and upregulated the protein expression levels of Nox4 and p22phox in the ileum tissues, while the same dose of CA and SAB made no difference within the observation period. Chlorogenic acid 35-38 NADPH oxidase 4 Rattus norvegicus 168-172 27959494-0 2017 Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid. Chlorogenic acid 66-82 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 20-51 28056918-7 2017 RESULTS: The inhibitory effect of FBE/F1 on adipocyte triglyceride accumulation was attributed to total phenolic (F2) and chlorogenic acid enriched (F3-2) fractions that both inhibited by 75%. Chlorogenic acid 122-138 N-acetyltransferase domain containing 1 Mus musculus 149-153 28123461-5 2017 Intravenous injection of high-dose ChA or CA (7 mg/kg) markedly increased the peroxide production in the venular walls and upregulated the protein expression levels of Nox4 and p22phox in the ileum tissues, while the same dose of CA and SAB made no difference within the observation period. Chlorogenic acid 35-38 cytochrome b-245 alpha chain Rattus norvegicus 177-184 27687881-6 2016 It was found that protocatechuic acid, chlorogenic acid, protocatechualdehyde, rutin, isoquercitrin, astragalin, and dicaffeoylquinic acid B had evident combination with lipase-linked magnetic microspheres. Chlorogenic acid 39-55 lipase, endothelial Mus musculus 170-176 29375639-8 2017 AEL, caffeic, and chlorogenic acids were able to reduce serum uric acid levels in hyperuricemic mice probably through inhibition of liver xanthine oxidase activity and significantly decreased the paw edema induced by MSU crystals. Chlorogenic acid 18-35 xanthine dehydrogenase Mus musculus 138-154 28163121-3 2017 In the present study, we investigated the effects of EGCG or chlorogenic acid on the PGE2-stimulated osteoprotegerin synthesis in MC3T3-E1 cells. Chlorogenic acid 61-77 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 101-116 28033335-0 2016 Chlorogenic Acid Prevents Osteoporosis by Shp2/PI3K/Akt Pathway in Ovariectomized Rats. Chlorogenic acid 0-16 protein tyrosine phosphatase, non-receptor type 11 Rattus norvegicus 42-46 28033335-0 2016 Chlorogenic Acid Prevents Osteoporosis by Shp2/PI3K/Akt Pathway in Ovariectomized Rats. Chlorogenic acid 0-16 AKT serine/threonine kinase 1 Rattus norvegicus 52-55 27374553-0 2016 Multispectroscopic and docking studies on the binding of chlorogenic acid isomers to human serum albumin: Effects of esteryl position on affinity. Chlorogenic acid 57-73 albumin Homo sapiens 91-104 27374553-2 2016 In this work, chlorogenic acid (CA) and its two positional isomers, neochlorogenic acid (NCA) and cryptochlorogenic acid (CCA), were investigated for their binding reactions with human serum albumin (HSA) using fluorescence, ultraviolet-visible, Fourier transform infrared and circular dichroism spectroscopies, as well as molecular docking. Chlorogenic acid 14-30 albumin Homo sapiens 185-198 27827954-5 2016 Thus, chlorogenic acid can dissociate PA1 aggregates while catechin is inactive. Chlorogenic acid 6-22 PAXIP1 associated glutamate rich protein 1 Homo sapiens 38-41 27529448-7 2016 RSL phenolics chlorogenic acid, quercetin-3-glucoside, and quercetin-malonyl-glucoside were bioaccessible in the TIM-1 digestion model, but had relatively low recovery. Chlorogenic acid 14-30 regulator of sex limited protein-Slp Mus musculus 0-3 27657123-0 2016 The Extract of Aster Koraiensis Prevents Retinal Pericyte Apoptosis in Diabetic Rats and Its Active Compound, Chlorogenic Acid Inhibits AGE Formation and AGE/RAGE Interaction. Chlorogenic acid 110-126 advanced glycosylation end product-specific receptor Rattus norvegicus 158-162 27657123-9 2016 Among these compounds, chlorogenic acid significantly reduced AGE formation as well as AGE/RAGE (receptor for AGEs) binding activity. Chlorogenic acid 23-39 advanced glycosylation end product-specific receptor Rattus norvegicus 91-95 27347406-12 2016 Western blotting detection indicated that chlorogenic acid may prohibit the decrease of Bcl-2 and the increase of Bax during apoptosis, thereby inhibiting osteoblast apoptosis and preventing the deterioration of femoral head necrosis. Chlorogenic acid 42-58 BCL2, apoptosis regulator Rattus norvegicus 88-93 27513569-0 2016 Combination of chlorogenic acid and salvianolic acid B protects against polychlorinated biphenyls-induced oxidative stress through Nrf2. Chlorogenic acid 15-31 nuclear factor, erythroid derived 2, like 2 Mus musculus 131-135 27367057-0 2016 Chlorogenic acid inhibits cholestatic liver injury induced by alpha-naphthylisothiocyanate: involvement of STAT3 and NFkappaB signalling regulation. Chlorogenic acid 0-16 signal transducer and activator of transcription 3 Mus musculus 107-112 27367057-0 2016 Chlorogenic acid inhibits cholestatic liver injury induced by alpha-naphthylisothiocyanate: involvement of STAT3 and NFkappaB signalling regulation. Chlorogenic acid 0-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 117-125 27147449-7 2016 Foliar expression of the hydroxycinnamoyl-CoA quinate hydroxycinnamoyl transferase (HQT) and 3-hydroxy-3-methylglutaryl CoA reductase I (HMGR1) genes, which are involved in chlorogenic acid and steroidal glycoalkaloid biosynthesis, respectively, also increased in response to tuber herbivory. Chlorogenic acid 173-189 HQT Solanum tuberosum 25-82 27147449-7 2016 Foliar expression of the hydroxycinnamoyl-CoA quinate hydroxycinnamoyl transferase (HQT) and 3-hydroxy-3-methylglutaryl CoA reductase I (HMGR1) genes, which are involved in chlorogenic acid and steroidal glycoalkaloid biosynthesis, respectively, also increased in response to tuber herbivory. Chlorogenic acid 173-189 HQT Solanum tuberosum 84-87 27147449-7 2016 Foliar expression of the hydroxycinnamoyl-CoA quinate hydroxycinnamoyl transferase (HQT) and 3-hydroxy-3-methylglutaryl CoA reductase I (HMGR1) genes, which are involved in chlorogenic acid and steroidal glycoalkaloid biosynthesis, respectively, also increased in response to tuber herbivory. Chlorogenic acid 173-189 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 Solanum tuberosum 137-142 27347406-12 2016 Western blotting detection indicated that chlorogenic acid may prohibit the decrease of Bcl-2 and the increase of Bax during apoptosis, thereby inhibiting osteoblast apoptosis and preventing the deterioration of femoral head necrosis. Chlorogenic acid 42-58 BCL2 associated X, apoptosis regulator Rattus norvegicus 114-117 26777909-0 2015 Chlorogenic Acid Maintains Glucose Homeostasis through Modulating the Expression of SGLT-1, GLUT-2, and PLG in Different Intestinal Segments of Sprague-Dawley Rats Fed a High-Fat Diet. Chlorogenic acid 0-16 solute carrier family 5 member 1 Rattus norvegicus 84-90 27270110-9 2016 The results showed that plasma chlorogenic acid exhibited negative associations with fasting blood glucose, glycated hemoglobin and C-reactive protein, whereas plasma total coffee polyphenol and plasma caffeic acid were weakly associated with these biomarkers. Chlorogenic acid 31-47 C-reactive protein Homo sapiens 132-150 27109860-1 2016 Coffee is a rich source of polyphenols, primarily chlorogenic acids (CGA). Chlorogenic acid 50-67 chromogranin A Homo sapiens 69-72 27013782-7 2016 In chlorogenic acid-LD group, serum triglycerides, free fatty acids, hepatic triglycerides and cholesterol were decreased, the proportion of C20:1, C24:1 and C18:3n-6, Delta9-18 and Delta6-desaturase activity index in the liver were decreased, and the proportion of C18:3n-3 acid was increased, compared to the LD group. Chlorogenic acid 3-19 fatty acid desaturase 2 Rattus norvegicus 188-199 26927040-0 2016 Antidepressant Potential of Chlorogenic Acid-Enriched Extract from Eucommia ulmoides Oliver Bark with Neuron Protection and Promotion of Serotonin Release through Enhancing Synapsin I Expression. Chlorogenic acid 28-44 synapsin I Rattus norvegicus 173-183 27847821-9 2016 Following that, we found rutin and chlorogenic acid (10-100 muM) could significantly increase cell viability and decrease the production of IL-6 in UVB models. Chlorogenic acid 35-51 interleukin 6 Mus musculus 140-144 26386740-0 2016 Chlorogenic acid improves ex vivo vessel function and protects endothelial cells against HOCl-induced oxidative damage, via increased production of nitric oxide and induction of Hmox-1. Chlorogenic acid 0-16 heme oxygenase 1 Homo sapiens 178-184 27168850-0 2016 Chlorogenic acid induces apoptosis to inhibit inflammatory proliferation of IL-6-induced fibroblast-like synoviocytes through modulating the activation of JAK/STAT and NF-kappaB signaling pathways. Chlorogenic acid 0-16 interleukin 6 Homo sapiens 76-80 27168850-0 2016 Chlorogenic acid induces apoptosis to inhibit inflammatory proliferation of IL-6-induced fibroblast-like synoviocytes through modulating the activation of JAK/STAT and NF-kappaB signaling pathways. Chlorogenic acid 0-16 nuclear factor kappa B subunit 1 Homo sapiens 168-177 26984670-1 2016 In the present study, we investigated the effects and molecular mechanism of 5-caffeoylquinic acid (5-CQA), a natural phenolic compound isolated from Ligularia fischeri, on cell invasion, proliferation and adhesion in p53 wild-type A549 and p53-deficient H1299 non-small cell lung cancer (NSCLC) cells. Chlorogenic acid 100-105 tumor protein p53 Homo sapiens 218-221 26984670-4 2016 Anti-invasive activity of 5-CQA in A549 cells was mediated by the inactivation of p70(S6K)-dependent signaling pathway. Chlorogenic acid 26-31 ribosomal protein S6 kinase B1 Homo sapiens 82-85 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Chlorogenic acid 16-32 interleukin 6 Homo sapiens 89-93 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Chlorogenic acid 16-32 C-C motif chemokine ligand 7 Homo sapiens 108-112 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Chlorogenic acid 16-32 C-X-C motif chemokine ligand 8 Homo sapiens 117-122 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Chlorogenic acid 16-32 interleukin 31 Homo sapiens 141-157 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Chlorogenic acid 16-32 interleukin 6 Homo sapiens 255-259 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Chlorogenic acid 16-32 C-X-C motif chemokine ligand 8 Homo sapiens 261-266 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Chlorogenic acid 16-32 C-C motif chemokine ligand 2 Homo sapiens 268-272 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Chlorogenic acid 16-32 C-C motif chemokine ligand 7 Homo sapiens 277-281 26756813-5 2016 Further study showed that treating the pulp discs with CHA remarkably reduced levels of lipoxygenase, beta-galactosidase, NADP-malic enzyme, and enzymatic activities of lipoxygenase and UDP-glucose pyrophosphorylase, all of which are known as promoters of fruit ripening and senescence. Chlorogenic acid 55-58 beta-galactosidase Malus domestica 102-120 26777909-0 2015 Chlorogenic Acid Maintains Glucose Homeostasis through Modulating the Expression of SGLT-1, GLUT-2, and PLG in Different Intestinal Segments of Sprague-Dawley Rats Fed a High-Fat Diet. Chlorogenic acid 0-16 solute carrier family 2 member 2 Rattus norvegicus 92-98 25981047-7 2015 Our analysis using leaf and petal tissues of the transgenic plants indicates that AtMYB11 enhances flavonol and chlorogenic acid (CGA) biosynthesis in tobacco through up-regulation of the biosynthetic genes. Chlorogenic acid 112-128 myb domain protein 11 Arabidopsis thaliana 82-89 26514546-11 2015 The verapamil (a P-gp inhibitor) and intestinal dysbacteriosis model induced by norfloxacin increased the P(app) and K(a) of intestinal absorption of chlorogenic acid. Chlorogenic acid 150-166 phosphoglycolate phosphatase Rattus norvegicus 17-21 26496857-0 2015 Amplification by (-)-epigallocatechin gallate and chlorogenic acid of TNF-alpha-stimulated interleukin-6 synthesis in osteoblasts. Chlorogenic acid 50-66 tumor necrosis factor Mus musculus 70-79 26496857-0 2015 Amplification by (-)-epigallocatechin gallate and chlorogenic acid of TNF-alpha-stimulated interleukin-6 synthesis in osteoblasts. Chlorogenic acid 50-66 interleukin 6 Mus musculus 91-104 26037533-6 2015 Chlorogenic acid (100 muM) showed inhibitory activity with the inhibitory percentage of 19.8%, while the other compounds showed no inhibitory activity. Chlorogenic acid 0-16 latexin Homo sapiens 22-25 26278267-9 2015 HPLC analysis of MCS showed this extract is containing chlorogenic acid as a phenolic compound. Chlorogenic acid 55-71 Miles-Carpenter X-linked mental retardation syndrome Homo sapiens 17-20 26713522-7 2015 RESULTS: The combination of lapatinib and chlorogenic acid inhibited the expression of CD206 induced by IL-13[(42.17%+-2.59%) vs (61.15%+-7.58%), P<0.05]. Chlorogenic acid 42-58 mannose receptor, C type 1 Mus musculus 87-92 26713522-7 2015 RESULTS: The combination of lapatinib and chlorogenic acid inhibited the expression of CD206 induced by IL-13[(42.17%+-2.59%) vs (61.15%+-7.58%), P<0.05]. Chlorogenic acid 42-58 interleukin 13 Mus musculus 104-109 26713522-9 2015 The combination of lapatinib and chlorogenic acid significantly reduced metastatic nodes in lung[P<0.05], and also significantly decreased the percentage of CD206(+) cells in breast cancer compared to controls[(6.08%+-2.60%) vs(29.04%+-5.86%), P<0.05]. Chlorogenic acid 33-49 mannose receptor, C type 1 Mus musculus 160-165 25959621-0 2015 Instant coffee extract with high chlorogenic acids content inhibits hepatic G-6-Pase in vitro, but does not reduce the glycaemia. Chlorogenic acid 33-50 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 76-84 26019132-0 2015 Chlorogenic Acid Activates CFTR-Mediated Cl- Secretion in Mice and Humans: Therapeutic Implications for Chronic Rhinosinusitis. Chlorogenic acid 0-16 cystic fibrosis transmembrane conductance regulator Mus musculus 27-31 26019132-7 2015 SUBJECTS AND METHODS: Chlorogenic acid was tested on primary murine nasal septal epithelial (MNSE) (CFTR(+/+) and transgenic CFTR(-/-)) and human sinonasal epithelial (HSNE) (CFTR(+/+) and F508del/F508del) cultures under pharmacologic conditions in Ussing chambers to evaluate effects on transepithelial Cl(-) transport. Chlorogenic acid 22-38 cystic fibrosis transmembrane conductance regulator Mus musculus 100-104 26019132-12 2015 However, the absence of elevated cellular cAMP and phosphorylation the CFTR R-D indicates chlorogenic acid does not work through a PKA-dependent mechanism. Chlorogenic acid 90-106 CF transmembrane conductance regulator Homo sapiens 71-75 26019132-13 2015 CONCLUSION: Chlorogenic acid is a water-soluble agent that promotes CFTR-mediated Cl(-) transport in mouse and human sinonasal epithelium. Chlorogenic acid 12-28 cystic fibrosis transmembrane conductance regulator Mus musculus 68-72 25186103-2 2015 5-Caffeoylquinic acid (5-CQA) is the most studied CGA, but the mechanism of its hypolipidaemic effect remains unclear. Chlorogenic acid 23-28 chromogranin A Rattus norvegicus 50-53 25959621-4 2015 Instant coffee extract with high chlorogenic acids content (37.8%) inhibited (p < 0.05) the G-6-Pase activity of the hepatocyte microsomal fraction in a dose-dependent way (up to 53), but IV administration of this extract did not change the glycaemia (p > 0.05). Chlorogenic acid 33-50 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 95-103 25959621-6 2015 It was concluded that instant coffee extract with high content of chlorogenic acids inhibited hepatic G-6-Pase in vitro, but failed to reduce the glycaemia probably because the coffee chlorogenic acids did not reach enough levels within the hepatocytes to inhibit the G-6-Pase and reduce the liver glucose output. Chlorogenic acid 66-83 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 102-110 25634525-0 2015 Shp2 regulates chlorogenic acid-induced proliferation and adipogenic differentiation of bone marrow-derived mesenchymal stem cells in adipogenesis. Chlorogenic acid 15-31 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 0-4