PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24044418-5	2013	Heating of the tap water with low pH led to a more significant increase of chloroform and a more significant short-term increase of DCAN.	Chloroform	75-85	nuclear RNA export factor 1	Homo sapiens	15-18
23989307-2	2013	Oddly, the presence of a sterically demanding tert-butyl group adjacent to the PH2 centre renders the molecule very sensitive to loss of PH3 and formation of 3,5-di-tert-butyl-phenol in chloroform solutions in the presence of air.	Chloroform	186-196	polyhomeotic homolog 2	Homo sapiens	79-82
23996390-4	2013	METHODS: IGF-1 was extracted from the six deer antler velvet supplements using chloroform and acetonitrile precipitation methods.	Chloroform	79-89	insulin like growth factor 1	Homo sapiens	9-14
24028122-3	2013	Our MP2/6-31G+(d) results show substantial increases of the dipole moment of both retinal derivatives in solution as compared with the gas-phase results (between 22% and 26% in chloroform and between 55% and 99% in water).	Chloroform	177-187	tryptase pseudogene 1	Homo sapiens	4-7
23763335-10	2013	DISCUSSION AND CONCLUSION: The cold chloroform extract of young fruits from Northern region appeared to contain anticancer active compounds against KB cells because of its high anti-proliferation and MMP-2 inhibition activities.	Chloroform	36-46	matrix metallopeptidase 2	Homo sapiens	200-205
23922034-6	2013	It has been concluded that while DFT 6-31+G(d,p) method provides accurate enol ratio in DMSO, MeOH, and DCM, in order to obtain accurate results for the other solvents the MP2 aug-cc-pVDZ level calculations should be used for CH3CN and CHCl3 solutions.	Chloroform	236-241	tryptase pseudogene 1	Homo sapiens	172-175
24354242-4	2013	In this study we analyzed at the molecular level, the amplification of c-Met receptor mRNA from gastric tumor tissue of patients who underwent gastrectomy, using the acid guanidinium-thiocyanate-phenol-chloroform method and the semiquantitative Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) method.	Chloroform	202-212	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	71-76
23837445-0	2013	Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways.	Chloroform	51-61	nuclear factor kappa B subunit 1	Homo sapiens	122-131
23837445-0	2013	Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways.	Chloroform	51-61	tumor protein p53	Homo sapiens	133-136
23837445-0	2013	Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways.	Chloroform	51-61	BCL2 apoptosis regulator	Homo sapiens	141-146
22674731-5	2013	The n-hexane and chloroform fraction of the methanol extract of C. sadleriana exhibited remarkable COX-1 and COX-2 inhibiting effects in vitro.	Chloroform	17-27	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	99-104
23548280-13	2013	Further separation of this fraction in a less polar solvent (30:1 chloroform:methanol) resolved at least 5 lipid-containing compounds, which likely contribute to the anti-RV activity associated with bovine MFGM.	Chloroform	66-76	milk fat globule EGF and factor V/VIII domain containing	Bos taurus	206-210
23590386-2	2013	Among the solvents used, including dichloromethane, chloroform, tetrahydrofuran, and carbon disulfide (CS2), CS2 was the best to induce fibril formation because its solubility parameter is closest to those of the P3AT derivatives.	Chloroform	52-62	chorionic somatomammotropin hormone 2	Homo sapiens	109-112
23611474-1	2013	This paper describes an investigation of the interfacial chemistry that enables formation of a multielectron ground-state charge-transfer (CT) complex of oleate-coated PbS quantum dots (QDs) and tetracyanoquinodimethane (TCNQ) in CHCl3 dispersions.	Chloroform	230-235	cholinergic receptor muscarinic 3	Homo sapiens	168-171
22674731-5	2013	The n-hexane and chloroform fraction of the methanol extract of C. sadleriana exhibited remarkable COX-1 and COX-2 inhibiting effects in vitro.	Chloroform	17-27	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	109-114
23402364-4	2013	In contrast, reddish-orange compound(s) characteristic of o-quinone- and nitroso-VP-16 were readily generated in a hydrophobic medium (chloroform) in an oxygen-dependent manner.	Chloroform	135-145	host cell factor C1	Homo sapiens	81-86
23402364-5	2013	Similar products were also formed when the VP-16 radical, generated from VP-16 and horseradish peroxidase/H2O2, was exposed directly to ( )NO in chloroform in the presence of oxygen.	Chloroform	145-155	host cell factor C1	Homo sapiens	43-48
23402364-5	2013	Similar products were also formed when the VP-16 radical, generated from VP-16 and horseradish peroxidase/H2O2, was exposed directly to ( )NO in chloroform in the presence of oxygen.	Chloroform	145-155	host cell factor C1	Homo sapiens	73-78
23437193-2	2013	We recently reported anti-oxidant property of chloroform fraction of Centratherum anthelminticum (L.) seeds (CACF) by inhibiting tumor necrosis factor-alpha (TNF-alpha)-induced growth of human breast cancer cells.	Chloroform	46-56	tumor necrosis factor	Homo sapiens	129-156
22834918-4	2013	However, organic solvents, such as chloroform or dichloromethane, are usually used for the fabrication of a PLCL scaffold through conventional methods.	Chloroform	35-45	phospholipase C-like 1	Mus musculus	108-112
23143927-0	2013	Application of an updated physiologically based pharmacokinetic model for chloroform to evaluate CYP2E1-mediated renal toxicity in rats and mice.	Chloroform	74-84	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	97-103
23864896-0	2013	Baicalein, Ethyl Acetate, and Chloroform Extracts of Scutellaria baicalensis Inhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses.	Chloroform	30-40	neuraminidase 1	Homo sapiens	89-102
23864896-2	2013	Ethyl acetate (EtOAc) and chloroform extracts inhibited in vitro neuraminidase (NA) enzymatic activity and viral replication more than methanol (MeOH) extract.	Chloroform	26-36	neuraminidase 1	Homo sapiens	65-78
23448585-3	2013	The results indicate that CCl(4) was reduced by AA at a pH of 13 (>pKa(2, AA) of 11.79) and chloroform (CHCl3) was a transformation byproduct of CCl(4).	Chloroform	95-105	C-C motif chemokine ligand 4	Homo sapiens	26-32
23448585-3	2013	The results indicate that CCl(4) was reduced by AA at a pH of 13 (>pKa(2, AA) of 11.79) and chloroform (CHCl3) was a transformation byproduct of CCl(4).	Chloroform	95-105	C-C motif chemokine ligand 4	Homo sapiens	148-154
23448585-3	2013	The results indicate that CCl(4) was reduced by AA at a pH of 13 (>pKa(2, AA) of 11.79) and chloroform (CHCl3) was a transformation byproduct of CCl(4).	Chloroform	107-112	C-C motif chemokine ligand 4	Homo sapiens	26-32
23448585-3	2013	The results indicate that CCl(4) was reduced by AA at a pH of 13 (>pKa(2, AA) of 11.79) and chloroform (CHCl3) was a transformation byproduct of CCl(4).	Chloroform	107-112	C-C motif chemokine ligand 4	Homo sapiens	148-154
23448585-4	2013	When CCl(4) levels were reduced to near complete disappearance, the decrease of CHCl(3) was then observed.	Chloroform	80-87	C-C motif chemokine ligand 4	Homo sapiens	5-11
23448585-8	2013	In the absence or presence of iron minerals, the fraction of CCl(4) transformed to CHCl(3) was less than 1, indicating simultaneous one- and two-electron transfer processes.	Chloroform	83-90	C-C motif chemokine ligand 4	Homo sapiens	61-67
24003692-2	2013	Since "tthe middle of 2007 the concentration of chloroform and other TGM in tests of tap water were established to be defined at levels steadily below hygienic maximum concentration limits.	Chloroform	48-58	nuclear RNA export factor 1	Homo sapiens	85-88
23376522-7	2013	Correlations among DBP levels varied, with the strongest linear correlation observed between chloroform and chloral hydrate levels (R(2)=0.77).	Chloroform	93-103	D-box binding PAR bZIP transcription factor	Homo sapiens	19-22
23222181-5	2012	When considering both THM exposure and maternal genotypes, the largest associations were found for third trimester among total THM (TTHM) and chloroform-exposed women with the GSTM1-0 genotype (OR: 4.37; 95% CI: 1.36-14.08 and OR: 5.06; 95% CI: 1.50-17.05, respectively).	Chloroform	142-152	glutathione S-transferase mu 1	Homo sapiens	176-181
23222181-6	2012	A test of interaction between internal THM dose and GSTM1-0 genotype suggested a modifying effect of exposure to chloroform and bromodichloromethane on LBW risk.	Chloroform	113-123	glutathione S-transferase mu 1	Homo sapiens	52-57
23204928-8	2012	In negative mode as well, the maximum number of MS2 features was detected in methanol/chloroform/water and acetone/isopropanol extracts.	Chloroform	86-96	MS2	Homo sapiens	48-51
24278618-6	2012	We found that the chloroform fraction of C. tschonoskii inhibited MDC at both the protein and mRNA levels in HaCaT cells, acting via the inhibition of STAT1 in the IFN-gamma signaling pathway.	Chloroform	18-28	signal transducer and activator of transcription 1	Homo sapiens	151-156
24278618-6	2012	We found that the chloroform fraction of C. tschonoskii inhibited MDC at both the protein and mRNA levels in HaCaT cells, acting via the inhibition of STAT1 in the IFN-gamma signaling pathway.	Chloroform	18-28	interferon gamma	Homo sapiens	164-173
23443381-7	2012	Using the strategy, the toxicity from test wastewater with 2.5 mg L-1 Hg2+, 0.5 mg L-1 allythiourea, or 0.25 mg L-1 chloroform could be successfully detected.	Chloroform	116-126	immunoglobulin kappa variable 1-16	Homo sapiens	66-69
23443381-7	2012	Using the strategy, the toxicity from test wastewater with 2.5 mg L-1 Hg2+, 0.5 mg L-1 allythiourea, or 0.25 mg L-1 chloroform could be successfully detected.	Chloroform	116-126	immunoglobulin kappa variable 1-16	Homo sapiens	83-86
23443381-7	2012	Using the strategy, the toxicity from test wastewater with 2.5 mg L-1 Hg2+, 0.5 mg L-1 allythiourea, or 0.25 mg L-1 chloroform could be successfully detected.	Chloroform	116-126	immunoglobulin kappa variable 1-16	Homo sapiens	83-86
24900570-6	2013	A model, which correlates the computed solvation free energy differences obtained in water and chloroform with Pgp-mediated efflux (in logarithmic scale), was successful in predicting Pgp efflux ratios for a wide range of chemically diverse compounds with a R(2) and root-mean-square error of 0.65 and 0.29, respectively.	Chloroform	95-105	ATP binding cassette subfamily B member 1	Homo sapiens	111-114
24900570-6	2013	A model, which correlates the computed solvation free energy differences obtained in water and chloroform with Pgp-mediated efflux (in logarithmic scale), was successful in predicting Pgp efflux ratios for a wide range of chemically diverse compounds with a R(2) and root-mean-square error of 0.65 and 0.29, respectively.	Chloroform	95-105	ATP binding cassette subfamily B member 1	Homo sapiens	184-187
23437193-2	2013	We recently reported anti-oxidant property of chloroform fraction of Centratherum anthelminticum (L.) seeds (CACF) by inhibiting tumor necrosis factor-alpha (TNF-alpha)-induced growth of human breast cancer cells.	Chloroform	46-56	tumor necrosis factor	Homo sapiens	158-167
22819394-6	2012	Interestingly, the opposite phenomenon was observed in CHCl(3) system, namely, the orange solution of HSA/1 in CHCl(3) was turned to a red-transparent gel by exposure to UV light.	Chloroform	55-62	olfactory receptor family 5 subfamily AC member 2	Homo sapiens	102-107
22819394-6	2012	Interestingly, the opposite phenomenon was observed in CHCl(3) system, namely, the orange solution of HSA/1 in CHCl(3) was turned to a red-transparent gel by exposure to UV light.	Chloroform	111-118	olfactory receptor family 5 subfamily AC member 2	Homo sapiens	102-107
22872137-4	2012	The computed reduction potentials of the Co(2+)/Co(+) couple imply that the Co(+)-H(H(2)O) interaction causes a greater anodic shift [5-98 mV vs. the normal hydrogen electrode (NHE) in chloroform solvent] than the analogous Co(+)-H(imidazole) interaction (1 mV vs. NHE) in the reduction potential of the Co(2+)/Co(+) couple.	Chloroform	185-195	solute carrier family 9 member C1	Homo sapiens	177-180
21919561-5	2012	Promising GI50 values of 1.96, 4.34 and 4.65 microg mL-1 were observed for the extract, its chloroform and ethyl acetate fractions, respectively.	Chloroform	92-102	L1 cell adhesion molecule	Mus musculus	52-56
22690917-0	2012	Photochemical molecular storage of Cl2, HCl, and COCl2: synthesis of organochlorine compounds, salts, ureas, and polycarbonate with photodecomposed chloroform.	Chloroform	148-158	endogenous retrovirus group W member 5	Homo sapiens	35-38
22474512-0	2012	Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells.	Chloroform	0-10	tumor necrosis factor	Homo sapiens	70-97
22935376-5	2012	Along with the characterization of the morphology of the obtained polymers via SEM and BET analysis, the beneficial nature of chloroform as porogen for imprinting 4-NP was experimentally demonstrated and verified by findings obtained from complementary molecular dynamics simulations.	Chloroform	126-136	delta/notch like EGF repeat containing	Homo sapiens	87-90
21919561-6	2012	The chloroform active subfraction I (GI50 = 2.97 microg mL-1) yielded betulin (1), betulinic acid (2) and ursolic acid (3) upon purification.	Chloroform	4-14	L1 cell adhesion molecule	Mus musculus	56-60
22024336-7	2011	In HEK 293 cells stably expressing cardiac ion channel genes, trichloromethane reduced hNav1.5, HCN2, and hERG currents with IC(50)s of 8.2, 3.3, and 4.0mM, respectively.	Chloroform	62-78	sodium voltage-gated channel alpha subunit 5	Homo sapiens	87-94
22004473-3	2012	All the concentrations (3.125-200 mg mL-1) of chloroform, ethyl acetate and n-butanol fractions of leaf extract, and n-hexane fraction of fruit extract completely inhibited the target fungal growth.	Chloroform	46-56	L1 cell adhesion molecule	Mus musculus	37-41
22024336-7	2011	In HEK 293 cells stably expressing cardiac ion channel genes, trichloromethane reduced hNav1.5, HCN2, and hERG currents with IC(50)s of 8.2, 3.3, and 4.0mM, respectively.	Chloroform	62-78	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	96-100
22024336-7	2011	In HEK 293 cells stably expressing cardiac ion channel genes, trichloromethane reduced hNav1.5, HCN2, and hERG currents with IC(50)s of 8.2, 3.3, and 4.0mM, respectively.	Chloroform	62-78	ETS transcription factor ERG	Homo sapiens	106-110
22024336-8	2011	These results demonstrate for the first time that trichloromethane can induce bradycardia or ventricular fibrillation, and the arrhythmogenic effect of trichloromethane is related to the inhibition of multiple ionic currents including I(Ca.L), I(to), I(Na), HCN2, and hERG channels.	Chloroform	152-168	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	258-262
22024336-8	2011	These results demonstrate for the first time that trichloromethane can induce bradycardia or ventricular fibrillation, and the arrhythmogenic effect of trichloromethane is related to the inhibition of multiple ionic currents including I(Ca.L), I(to), I(Na), HCN2, and hERG channels.	Chloroform	152-168	ETS transcription factor ERG	Homo sapiens	268-272
21565308-4	2011	The total volume of chloroform was reduced to 50 muL in comparison with 10 mL consumed in batch.	Chloroform	20-30	tripartite motif containing 37	Homo sapiens	49-52
21907259-2	2011	Microarray analyses and quantitative real-time PCR using human renal tubular cells showed that the mRNA expression of VNN-1 which encodes vanin-1, increased after the exposure of these cells to organic solvents (allyl alcohol, ethylene glycol, formaldehyde, chloroform, and phenol) for 24h.	Chloroform	258-268	vanin 1	Homo sapiens	118-123
21907259-2	2011	Microarray analyses and quantitative real-time PCR using human renal tubular cells showed that the mRNA expression of VNN-1 which encodes vanin-1, increased after the exposure of these cells to organic solvents (allyl alcohol, ethylene glycol, formaldehyde, chloroform, and phenol) for 24h.	Chloroform	258-268	vanin 1	Homo sapiens	138-145
22375399-2	2011	METHOD: APR essential oil was extracted by steam distillation, and the chemical components were identified by GC-MS. Enzymatic activity was performed by using recombinant NAAA-overexpressing protein and detected by LC-MS. Lipids were extracted by methonal/chloroform mixure and analyzed by LC-MS. mRNA and protein expression levels of proinflammatory genes were examined by Real time-PCR and ELISA assay kit, respectively.	Chloroform	256-266	N-acylethanolamine acid amidase	Mus musculus	171-175
20842417-8	2011	The levels of T-lymphocyte subsets in the TCM group were quite different from the WM group, with much more the percentage of CD4+ and the CD4+/CD8+ ratio on days 7, 14, and 28 and much less the percentage of CD8+ on days 4 and 28.	Chloroform	42-45	CD4 molecule	Homo sapiens	125-128
20842417-8	2011	The levels of T-lymphocyte subsets in the TCM group were quite different from the WM group, with much more the percentage of CD4+ and the CD4+/CD8+ ratio on days 7, 14, and 28 and much less the percentage of CD8+ on days 4 and 28.	Chloroform	42-45	CD4 molecule	Homo sapiens	138-141
20842417-8	2011	The levels of T-lymphocyte subsets in the TCM group were quite different from the WM group, with much more the percentage of CD4+ and the CD4+/CD8+ ratio on days 7, 14, and 28 and much less the percentage of CD8+ on days 4 and 28.	Chloroform	42-45	CD8a molecule	Homo sapiens	143-146
20842417-8	2011	The levels of T-lymphocyte subsets in the TCM group were quite different from the WM group, with much more the percentage of CD4+ and the CD4+/CD8+ ratio on days 7, 14, and 28 and much less the percentage of CD8+ on days 4 and 28.	Chloroform	42-45	CD8a molecule	Homo sapiens	208-211
21766123-1	2011	The FTIR spectra of chloroform (Cl(3)CH) in mixtures with various electron donors (B = CH(3)CCH, HCCH, NCCD(3), ClCD(3) and CO) have been studied in liquefied Kr.	Chloroform	20-30	RUNX family transcription factor 2	Homo sapiens	112-116
21596018-4	2011	In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway.	Chloroform	86-96	epidermal growth factor receptor	Homo sapiens	147-151
21596018-4	2011	In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway.	Chloroform	86-96	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	163-168
21596018-4	2011	In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway.	Chloroform	86-96	mitogen-activated protein kinase 3	Homo sapiens	183-189
21596018-4	2011	In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway.	Chloroform	86-96	epidermal growth factor receptor	Homo sapiens	213-217
21596018-4	2011	In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway.	Chloroform	86-96	zinc fingers and homeoboxes 2	Homo sapiens	165-168
21596018-4	2011	In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway.	Chloroform	86-96	mitogen-activated protein kinase kinase 7	Homo sapiens	226-229
21596018-4	2011	In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway.	Chloroform	86-96	mitogen-activated protein kinase 3	Homo sapiens	230-236
21970764-3	2011	Scattering data for the PgC(11)Cu and PgC(13)Cu in chloroform fitted as core-shell spheres with a total spherical radius of about 22.7 and 22.9 A respectively.	Chloroform	51-61	progastricsin	Homo sapiens	24-27
21970764-3	2011	Scattering data for the PgC(11)Cu and PgC(13)Cu in chloroform fitted as core-shell spheres with a total spherical radius of about 22.7 and 22.9 A respectively.	Chloroform	51-61	progastricsin	Homo sapiens	38-41
21938745-8	2011	The photophysical properties of [(TTF-salphen)CuDy(hfac)(3)] (3) in chloroform solution highlight the redshift of the TTF salphen charge transfer (400 cm(-1)) relative to the analogue excitations in (TTF-salphen)Cu, which attest to the stability of these structures in solution.	Chloroform	68-78	ras homolog family member H	Homo sapiens	34-37
21938745-8	2011	The photophysical properties of [(TTF-salphen)CuDy(hfac)(3)] (3) in chloroform solution highlight the redshift of the TTF salphen charge transfer (400 cm(-1)) relative to the analogue excitations in (TTF-salphen)Cu, which attest to the stability of these structures in solution.	Chloroform	68-78	ras homolog family member H	Homo sapiens	118-121
21938745-8	2011	The photophysical properties of [(TTF-salphen)CuDy(hfac)(3)] (3) in chloroform solution highlight the redshift of the TTF salphen charge transfer (400 cm(-1)) relative to the analogue excitations in (TTF-salphen)Cu, which attest to the stability of these structures in solution.	Chloroform	68-78	ras homolog family member H	Homo sapiens	118-121
21889640-7	2011	For detection of 2,4,6-trinitrotoluene, the chloroform-based fluorescent microparticles achieved a lower limit of detection of 0.1 muM, as compared to 100 muM for the water-based fluorescent microparticles.	Chloroform	44-54	latexin	Homo sapiens	131-134
21889640-7	2011	For detection of 2,4,6-trinitrotoluene, the chloroform-based fluorescent microparticles achieved a lower limit of detection of 0.1 muM, as compared to 100 muM for the water-based fluorescent microparticles.	Chloroform	44-54	latexin	Homo sapiens	155-158
21635016-3	2011	The formation of the binuclear complex from the reaction of HATN-Me(6) with 2 equiv of Re(CO)(5)Cl in chloroform results in a 1:1 ratio of the syn and anti isomers.	Chloroform	102-112	synemin	Homo sapiens	143-146
21780487-3	2011	The block copolymeric thin film was initially cast from chloroform which is a good solvent for PEO.	Chloroform	56-66	twinkle mtDNA helicase	Homo sapiens	95-98
21290074-1	2011	The structures and intermolecular interactions in the halogen bonded complexes of anaesthetics (chloroform, halothane, enflurane and isoflurane) with formaldehyde were studied by ab initio MP2 and CCSD(T) methods.	Chloroform	96-106	tryptase pseudogene 1	Homo sapiens	189-192
21036577-5	2011	The chloroform-soluble fraction (ZAC) of the crude extract of this plant showed cytotoxic activity against human promyelocytic leukemia (HL-60) and myelomonocytic leukemia (WEHI-3) cells with IC(50) values of 73.06 and 42.22 mug/mL, respectively.	Chloroform	4-14	PLAG1 like zinc finger 1	Homo sapiens	33-36
21300767-2	2011	Of all the extracts tested, chloroform and ethyl acetate extracts of M piperita showed significant dose- and time-dependent anticarcinogenic activity leading to G1 cell cycle arrest and mitochondrial-mediated apoptosis, perturbation of oxidative balance, upregulation of Bax gene, elevated expression of p53 and p21 in the treated cells, acquisition of senescence phenotype, while inducing pro-inflammatory cytokines response.	Chloroform	28-38	BCL2 associated X, apoptosis regulator	Homo sapiens	271-274
21300767-2	2011	Of all the extracts tested, chloroform and ethyl acetate extracts of M piperita showed significant dose- and time-dependent anticarcinogenic activity leading to G1 cell cycle arrest and mitochondrial-mediated apoptosis, perturbation of oxidative balance, upregulation of Bax gene, elevated expression of p53 and p21 in the treated cells, acquisition of senescence phenotype, while inducing pro-inflammatory cytokines response.	Chloroform	28-38	tumor protein p53	Homo sapiens	304-307
21300767-2	2011	Of all the extracts tested, chloroform and ethyl acetate extracts of M piperita showed significant dose- and time-dependent anticarcinogenic activity leading to G1 cell cycle arrest and mitochondrial-mediated apoptosis, perturbation of oxidative balance, upregulation of Bax gene, elevated expression of p53 and p21 in the treated cells, acquisition of senescence phenotype, while inducing pro-inflammatory cytokines response.	Chloroform	28-38	H3 histone pseudogene 16	Homo sapiens	312-315
21288335-7	2011	RESULTS: Chloroform extract of H. antidysenterica (HA-2) and petroleum ether extract of V. canescens (VC-1) plants significantly reduced parasitaemia in P. berghei infected mice.	Chloroform	9-19	keratin 34	Mus musculus	51-55
20868645-7	2011	Lung samples of control and LVS-inoculated mice were quickly extracted with a methanol/chloroform solution, and the crude extract was directly analyzed by DESI-MS, with a total turnaround time of less than 10 min/sample.	Chloroform	87-97	lacking vigorous sperm	Mus musculus	28-31
22083995-8	2011	The chloroform fraction also suppressed p38, JNK and ERK1/2.	Chloroform	4-14	mitogen-activated protein kinase 14	Mus musculus	40-43
22083995-8	2011	The chloroform fraction also suppressed p38, JNK and ERK1/2.	Chloroform	4-14	mitogen-activated protein kinase 8	Mus musculus	45-48
22083995-0	2011	The chloroform fraction of Solanum nigrum suppresses nitric oxide and tumor necrosis factor-alpha in LPS-stimulated mouse peritoneal macrophages through inhibition of p38, JNK and ERK1/2.	Chloroform	4-14	mitogen-activated protein kinase 14	Mus musculus	167-170
22083995-8	2011	The chloroform fraction also suppressed p38, JNK and ERK1/2.	Chloroform	4-14	mitogen-activated protein kinase 3	Mus musculus	53-59
22083995-0	2011	The chloroform fraction of Solanum nigrum suppresses nitric oxide and tumor necrosis factor-alpha in LPS-stimulated mouse peritoneal macrophages through inhibition of p38, JNK and ERK1/2.	Chloroform	4-14	mitogen-activated protein kinase 8	Mus musculus	172-175
22083995-0	2011	The chloroform fraction of Solanum nigrum suppresses nitric oxide and tumor necrosis factor-alpha in LPS-stimulated mouse peritoneal macrophages through inhibition of p38, JNK and ERK1/2.	Chloroform	4-14	mitogen-activated protein kinase 3	Mus musculus	180-186
22083995-12	2011	The inhibition of iNOS, TNF-alpha and IL-6 by the chloroform fraction may be partly due to the suppression of p38, JNK and ERK1/2.	Chloroform	50-60	mitogen-activated protein kinase 14	Mus musculus	110-113
22083995-12	2011	The inhibition of iNOS, TNF-alpha and IL-6 by the chloroform fraction may be partly due to the suppression of p38, JNK and ERK1/2.	Chloroform	50-60	mitogen-activated protein kinase 8	Mus musculus	115-118
22083995-12	2011	The inhibition of iNOS, TNF-alpha and IL-6 by the chloroform fraction may be partly due to the suppression of p38, JNK and ERK1/2.	Chloroform	50-60	mitogen-activated protein kinase 3	Mus musculus	123-129
22083996-7	2011	Chloroform fractions also decreased LPS-induced NO production and expressions of iNOS and COX-2 in RAW264.7 cells.	Chloroform	0-10	nitric oxide synthase 2, inducible	Mus musculus	81-85
22083996-7	2011	Chloroform fractions also decreased LPS-induced NO production and expressions of iNOS and COX-2 in RAW264.7 cells.	Chloroform	0-10	cytochrome c oxidase II, mitochondrial	Mus musculus	90-95
20407683-9	2010	The computed results at the DFT/MP2 level also indicated that the IR intensity of the H-bond donor CH-stretch increases by two to three orders of magnitude for the CHCl(3) complex whereas for the fluoroform complex the same decreases by an order of magnitude, which are consistent with the trend reported in the case of C-HO type of blue shifting hydrogen bonds.	Chloroform	164-171	tryptase pseudogene 1	Homo sapiens	32-35
20933271-9	2011	Degrease with methanol/chloroform dramatically reduced the contents of VEGF, b-FGF, TGF-beta, and TNF-alpha within SISii, but further treatment could not significantly reduced the contents of growth factors.	Chloroform	23-33	vascular endothelial growth factor A	Rattus norvegicus	71-75
20933271-9	2011	Degrease with methanol/chloroform dramatically reduced the contents of VEGF, b-FGF, TGF-beta, and TNF-alpha within SISii, but further treatment could not significantly reduced the contents of growth factors.	Chloroform	23-33	tumor necrosis factor	Rattus norvegicus	98-107
20940364-7	2011	In 1847, the Scot James Young Simpson began to use chloroform as an anesthetic for obstetrics in Edinburgh.	Chloroform	51-61	3-oxoacid CoA-transferase 1	Homo sapiens	13-17
21115185-4	2011	The hydrophilic proteins were more effective precursors of chloroform (35.9 mumol L(-1) at 120 min), 35 times greater than that from the hydrophobic proteins; whereas the hydrophobic proteins were more potent precursors of direct-acting mutagens (maximum level of 50.1 rev muL(-1) at 30 s) than the hydrophilic proteins (maximum level of 3.38 rev muL(-1) at 60 min).	Chloroform	59-69	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	273-279
21115185-4	2011	The hydrophilic proteins were more effective precursors of chloroform (35.9 mumol L(-1) at 120 min), 35 times greater than that from the hydrophobic proteins; whereas the hydrophobic proteins were more potent precursors of direct-acting mutagens (maximum level of 50.1 rev muL(-1) at 30 s) than the hydrophilic proteins (maximum level of 3.38 rev muL(-1) at 60 min).	Chloroform	59-69	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	347-353
21506424-2	2011	METHOD: Mix and cultivate the chloroform extract of Chansu and MGC-803.	Chloroform	30-40	Mix paired-like homeobox	Homo sapiens	8-11
21117638-4	2010	Photolysis (270 nm) of diazoacetone in chloroform leads mainly to the ketene species through a concerted process, consistent with the predominance of the syn conformation in the diazoacetone electronic ground state and a zero quantum yield of the internal conversion process.	Chloroform	39-49	synemin	Homo sapiens	154-157
20601245-3	2010	A subtle structural rearrangement of the alpha/beta-subunits within the quaternary structure of HbA is responsible for the HbA fibril formation in the presence of 0.5% CHCl3.	Chloroform	168-173	sodium voltage-gated channel alpha subunit 2	Homo sapiens	96-99
20601245-3	2010	A subtle structural rearrangement of the alpha/beta-subunits within the quaternary structure of HbA is responsible for the HbA fibril formation in the presence of 0.5% CHCl3.	Chloroform	168-173	sodium voltage-gated channel alpha subunit 2	Homo sapiens	123-126
21139873-2	2010	A multi-route PBPK model described previously was used for computing the internal dose metrics in adults, neonates, children, the elderly and pregnant women following a multi-route exposure scenario to chloroform and to tri- and tetra-chloroethylene (TCE and PERC).	Chloroform	202-212	PPARG coactivator 1 beta	Homo sapiens	259-263
21166641-1	2010	Proteins tightly bound to DNA (TBP) comprise a group of proteins that remain bound to DNA after usual deproteinization procedures such as salting out and treatment with phenol or chloroform.	Chloroform	179-189	TATA-box binding protein	Homo sapiens	31-34
20379959-1	2010	CHCl(3) extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro.	Chloroform	0-7	aldo-keto reductase family 1 member B	Homo sapiens	105-121
26781239-11	2010	pentosaceus OZF for chloroform demonstrates the basic property of a cell, which may be due to the presence of carboxylic groups on the cell surface.	Chloroform	20-30	zinc finger protein 146	Homo sapiens	12-15
20576841-0	2010	Chloroform extract of hog barn dust modulates skeletal muscle ryanodine receptor calcium-release channel (RyR1).	Chloroform	0-10	ryanodine receptor 1	Homo sapiens	106-110
20673058-6	2010	The chloroform fraction significantly suppressed production of NO, PGE(2), and two pro-inflammatory cytokines (TNF-alpha and IL-1beta) in a dose-dependent manner with 50% inhibitory concentration values of 66.51, 90.96, 114.76, and 171.06 microg/mL, respectively.	Chloroform	4-14	tumor necrosis factor	Mus musculus	111-120
20673058-6	2010	The chloroform fraction significantly suppressed production of NO, PGE(2), and two pro-inflammatory cytokines (TNF-alpha and IL-1beta) in a dose-dependent manner with 50% inhibitory concentration values of 66.51, 90.96, 114.76, and 171.06 microg/mL, respectively.	Chloroform	4-14	interleukin 1 beta	Mus musculus	125-133
20673058-8	2010	The chloroform and ethyl acetate fractions reduced LPS-induced expressions of iNOS and COX-2 and activation of MAP kinases in a dose-dependent manner.	Chloroform	4-14	nitric oxide synthase 2, inducible	Mus musculus	78-82
20673058-8	2010	The chloroform and ethyl acetate fractions reduced LPS-induced expressions of iNOS and COX-2 and activation of MAP kinases in a dose-dependent manner.	Chloroform	4-14	cytochrome c oxidase II, mitochondrial	Mus musculus	87-92
20795624-4	2010	pTB adopts a single right-handed beta(6.3)-helical structure in a 1:1 mixture of methanol/chloroform with a length of approximately 45 A and a hydrophilic pore of ca.	Chloroform	90-100	polypyrimidine tract binding protein 1	Homo sapiens	0-3
19596853-2	2009	Here we demonstrate a simple method for rapid isolation of proteoglycans (RIP) employing phenol/guanidine/chloroform reagent to purify heparan sulfate (HS) PGs quantitatively from various tissues and cells.	Chloroform	106-116	regulation of phenobarbitol-inducible P450	Mus musculus	74-77
19885922-2	2010	For both pSer-Pro and pThr-Pro peptides in the gas phase and in chloroform, the most preferred conformation has the alpha-helical structure for the pSer/pThr residue, the down-puckered polyproline I structure for the Pro residue, and the cis prolyl peptide bond between the two residues, in which two hydrogen bonds between the phosphate oxygens with the backbone N--H groups seem to play a role.	Chloroform	64-74	parathyroid hormone 1 receptor	Homo sapiens	22-26
19885922-2	2010	For both pSer-Pro and pThr-Pro peptides in the gas phase and in chloroform, the most preferred conformation has the alpha-helical structure for the pSer/pThr residue, the down-puckered polyproline I structure for the Pro residue, and the cis prolyl peptide bond between the two residues, in which two hydrogen bonds between the phosphate oxygens with the backbone N--H groups seem to play a role.	Chloroform	64-74	parathyroid hormone 1 receptor	Homo sapiens	153-157
20150224-0	2010	Apoptotic effects of Physalis minima L. chloroform extract in human breast carcinoma T-47D cells mediated by c-myc-, p53-, and caspase-3-dependent pathways.	Chloroform	40-50	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	109-114
20150224-0	2010	Apoptotic effects of Physalis minima L. chloroform extract in human breast carcinoma T-47D cells mediated by c-myc-, p53-, and caspase-3-dependent pathways.	Chloroform	40-50	tumor protein p53	Homo sapiens	117-120
20150224-0	2010	Apoptotic effects of Physalis minima L. chloroform extract in human breast carcinoma T-47D cells mediated by c-myc-, p53-, and caspase-3-dependent pathways.	Chloroform	40-50	caspase 3	Homo sapiens	127-136
20150224-4	2010	The c-myc was significantly induced by the chloroform extract at the earlier phase of treatment, followed by p53 and caspase-3.	Chloroform	43-53	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	4-9
20150224-4	2010	The c-myc was significantly induced by the chloroform extract at the earlier phase of treatment, followed by p53 and caspase-3.	Chloroform	43-53	tumor protein p53	Homo sapiens	109-112
20150224-4	2010	The c-myc was significantly induced by the chloroform extract at the earlier phase of treatment, followed by p53 and caspase-3.	Chloroform	43-53	caspase 3	Homo sapiens	117-126
20150224-7	2010	Thus, the results from this study strongly suggest that the chloroform extract of P. minima induced apoptotic cell death via p53-, caspase-3-, and c-myc-dependent pathways.	Chloroform	60-70	tumor protein p53	Homo sapiens	125-128
20150224-7	2010	Thus, the results from this study strongly suggest that the chloroform extract of P. minima induced apoptotic cell death via p53-, caspase-3-, and c-myc-dependent pathways.	Chloroform	60-70	caspase 3	Homo sapiens	131-140
20150224-7	2010	Thus, the results from this study strongly suggest that the chloroform extract of P. minima induced apoptotic cell death via p53-, caspase-3-, and c-myc-dependent pathways.	Chloroform	60-70	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	147-152
19917107-11	2009	RESULTS: The chloroform fraction (I.2) derived from crude MeOH extract of the plant, in addition to Y2+3, a FA mix isolated from this fraction and containing palmitic acid, C18:2 and C18:1 isomers and stearic acid (1:5:8:1 ratio), reduced ET-induced IL-6 levels in SCp2 cells without affecting cell viability or morphology.	Chloroform	13-23	sterol carrier protein 2, liver	Mus musculus	265-269
19707680-2	2009	This phenomenon has been found by investigating the supramolecular assembly state of L-1 in mixed solvents of various chloroform (CHCl(3))/n-hexane (Hx) ratios.	Chloroform	118-128	immunoglobulin kappa variable 1-16	Homo sapiens	85-88
19707680-2	2009	This phenomenon has been found by investigating the supramolecular assembly state of L-1 in mixed solvents of various chloroform (CHCl(3))/n-hexane (Hx) ratios.	Chloroform	130-137	immunoglobulin kappa variable 1-16	Homo sapiens	85-88
20495720-1	2010	The reaction of Ru(3)(CO)(12) in chloroform with thioether ligands after 25 min of irradiation leads to the formation of mononuclear ruthenium(II) complexes of the general formula fac-[Ru(CO)(3)Cl(2)(S)] (S = thioether) if monodentate ligands are introduced.	Chloroform	33-43	FA complementation group C	Homo sapiens	180-183
20358949-6	2010	To control the roughness of the MEH-PPV organic layer, solvent printing was proposed in this work with various solvent mixture of chloroform, chlorobenzene and 1,2-dichlorobenzene on the top of the gravure printed MEH-PPV layers and a significant reduction in roughness was achieved.	Chloroform	130-140	epoxide hydrolase 1	Homo sapiens	32-35
19969449-3	2010	The maximum conversion yield (75%) was obtained using 240 IU of immobilized lipase, a benzoic acid/eugenol molar ratio of 1.22 dissolved in 4.6 ml chloroform at 41 degrees Celsius.	Chloroform	147-157	lipase	Staphylococcus aureus	76-82
20055405-2	2010	The 154 experimental ROE distance bounds that determine a beta-helical fold in chloroform are all satisfied in MD simulations starting from the folded and from a refolded structure.	Chloroform	79-89	amyloid beta precursor protein	Homo sapiens	56-62
19663434-10	2009	Fluorescence studies on PF2/6 in chloroform solution suggest there are no significant interchain interactions under these conditions.	Chloroform	33-43	sperm associated antigen 17	Homo sapiens	24-29
19673520-3	2009	Here we provide the first demonstration that bovine submaxillary mucin and porcine gastric mucin accelerate the rate of fatty acid p-nitrophenol ester hydrolysis up to 337 times and a carbon-carbon bond-forming Diels-Alder reaction between N-propylmaleimide and anthracene up to 200 times relative to the rates of the reference processes, which were performed in water and chloroform, respectively.	Chloroform	373-383	mucin 1, cell surface associated	Bos taurus	65-70
19673520-3	2009	Here we provide the first demonstration that bovine submaxillary mucin and porcine gastric mucin accelerate the rate of fatty acid p-nitrophenol ester hydrolysis up to 337 times and a carbon-carbon bond-forming Diels-Alder reaction between N-propylmaleimide and anthracene up to 200 times relative to the rates of the reference processes, which were performed in water and chloroform, respectively.	Chloroform	373-383	mucin 1, cell surface associated	Bos taurus	91-96
19479293-17	2009	Although a correlation of single compounds and AOX is difficult, chloroform was the predominant AOX.	Chloroform	65-75	acyl-CoA oxidase 1	Homo sapiens	96-99
19798983-1	2009	The effects of stirring speed, carrier concentration and reaction temperature on the transport of Pb(II) ion through bulk liquid membrane were studied with chloroform as membrane solvent and 2-ethylhexyl phosphonic acid-mono-2-ethylhexylester as carrier.	Chloroform	156-166	submaxillary gland androgen regulated protein 3B	Homo sapiens	98-104
19435638-2	2009	The organic carbon-normalized sorption coefficients (K(OC)) for diuron and phenanthrene (determined from single initial concentrations of 0.8mgL(-1) and 1.5mgL(-1), respectively) were consistently higher following solvent-conditioning of a whole soil with five organic solvents (acetonitrile, acetone, methanol, chloroform and dichloromethane).	Chloroform	312-322	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	53-58
19435638-3	2009	The relative increase in K(OC) was inversely related to the polarity of the conditioning solvent (i.e. greater increases in K(OC) were observed for the least polar solvents: chloroform and dichloromethane).	Chloroform	174-184	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	25-30
19435638-3	2009	The relative increase in K(OC) was inversely related to the polarity of the conditioning solvent (i.e. greater increases in K(OC) were observed for the least polar solvents: chloroform and dichloromethane).	Chloroform	174-184	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	124-129
19628070-3	2009	METHODS: The expression of CD154 was measured in 4 subsets-naive (N) and memory (M) CD154+ T-helper (Th) and T-cytotoxic (Tc) cells (ie, CD154+ ThN, CD154+ ThM, CD154+ TcN, and CD154+ TcM, respectively)-in the MLR of single blood samples obtained from 32 children with SBTx within 60 days of SBTx biopsy.	Chloroform	184-187	CD40 ligand	Homo sapiens	27-32
19402495-2	2009	Electrochemical reductive dechlorination of chloroform in acidic system was investigated using the Pd/PPy/foam-Ni electrode at ambient temperature.	Chloroform	44-54	pancreatic polypeptide	Homo sapiens	102-105
19569334-3	2009	Evaluation of reaction kinetics, product distribution, and C-isotope fractionation suggest that polychlorinated ethanes containing three alpha-Cl atoms reacted via reductive beta-elimination to the corresponding ethenes while CCl4-reduction leads predominantly to the formation of chloroform.	Chloroform	281-291	C-C motif chemokine ligand 4	Homo sapiens	226-230
18335002-1	2009	Volunteer studies suggest that showering/bathing with chlorinated tap water contributes to daily chloroform inhalation exposure for the majority of US adults.	Chloroform	97-107	nuclear RNA export factor 1	Homo sapiens	66-69
18335002-5	2009	Significant predictors of log personal air chloroform in our model (R(2)=0.34) included age, chloroform concentrations in home tap water, having no windows open at home during the sampling period, visiting a swimming pool during the sampling period, living in a mobile home/trailer or apartment versus living in a single family (detached) home, and being Non-Hispanic Black versus Non-Hispanic White, although the race/ethnicity estimates appear influenced by several outlying observations.	Chloroform	43-53	nuclear RNA export factor 1	Homo sapiens	127-130
19459745-5	2009	Anti-inflammatory screening revealed that N. sativa, N. orientalis, N. hispanica, N. arvensis n-hexane, and N. hispanica chloroform extracts had strong inhibitory activity (more than 80%) on COX-1 and N. orientalis, N. arvensis, and N. hispanica n-hexane extracts were most effective against COX-2, when the concentration of extracts was 100 microg/mL in both COX assays.	Chloroform	121-131	cytochrome c oxidase subunit 2	Saccharomyces cerevisiae S288C	292-297
19114462-7	2009	The hexane- and chloroform-soluble fractions at 50 microg/ml were the most potent, inhibiting by 77 and 63%, respectively, suggesting that the CYP3A inhibitors reside largely in these more lipophilic fractions.	Chloroform	16-26	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	143-148
19323732-2	2009	The GOX-containing microfibers were electrospun from emulsions prepared by dispersing aqueous GOX in PLA dissolved in a chloroform and N,N-dimethylformamide blend, using sorbitan monopalmitate as an emulsifier.	Chloroform	120-130	hydroxyacid oxidase 1	Homo sapiens	4-7
19402495-7	2009	Dechlorination experimental results indicate that, with the integrated analysis of removal efficiency and current efficiency, with the high current efficiency of 44.17%, the removal efficiency of chloroform on Pd/PPy/foam-Ni electrode was 49.23%, under the optimum conditions of the dechlorination current density of 0.05 mA x cm(-2) and the dechlorination time of 180 min.	Chloroform	196-206	pancreatic polypeptide	Homo sapiens	213-216
18950781-1	2009	The effect of chloroform on the chiroselective reaction between bilirubin (BR) and bovine serum albumin (BSA) at the interface between a heptane phase (including CHCl(3)) and an aqueous phase was investigated by means of the absorption and circular dichroism (CD) spectroscopies combined with a centrifugal liquid membrane (CLM) method, and a CLM microscopic fluorescence spectroscopy as well.	Chloroform	14-24	albumin	Homo sapiens	90-103
18950781-0	2009	Effect of chloroform on complexation and chiral aggregation of bilirubin-bovine serum albumin at heptane/water interface.	Chloroform	10-20	albumin	Homo sapiens	80-93
19123823-4	2009	But, the anti-syn interconversion occurs relatively faster in water solvent than in chloroform solvent.	Chloroform	84-94	synemin	Homo sapiens	14-17
18926719-5	2009	Herein, one such application has been further demonstrated in the detection and identification of background ions from LC solvents and APPI dopants, including water, acetonitrile, chloroform, methylene chloride, methanol, 2-propanol, hexanes, heptane, cyclohexane, acetone, tetrahydrofuran (THF), 1,4-dioxane, toluene, and anisole.	Chloroform	180-190	amyloid beta precursor protein	Homo sapiens	135-139
19373924-1	2009	The conformational study of N-acetyl-N"-methylamide of L-3,4-dehydroproline (Ac-Dhp-NHMe, the Dhp dipeptide) is carried out using hybrid density functional methods with the self-consistent reaction field method in the gas phase and in solution (chloroform and water).	Chloroform	245-255	immunoglobulin kappa variable 2-14 (pseudogene)	Homo sapiens	55-58
19373924-1	2009	The conformational study of N-acetyl-N"-methylamide of L-3,4-dehydroproline (Ac-Dhp-NHMe, the Dhp dipeptide) is carried out using hybrid density functional methods with the self-consistent reaction field method in the gas phase and in solution (chloroform and water).	Chloroform	245-255	dihydropyrimidinase	Homo sapiens	80-83
19373924-1	2009	The conformational study of N-acetyl-N"-methylamide of L-3,4-dehydroproline (Ac-Dhp-NHMe, the Dhp dipeptide) is carried out using hybrid density functional methods with the self-consistent reaction field method in the gas phase and in solution (chloroform and water).	Chloroform	245-255	dihydropyrimidinase	Homo sapiens	94-97
19514942-6	2009	Following chloroform administration, there was a decreased number of circulating neutrophils in the blood in all treatment groups, but neutrophil function in lung homogenates, as evaluated using an assay for myeloperoxidase activity following lipopolysaccharide and N-Formyl-Met-Leu-Phe stimulation, was not compromised.	Chloroform	10-20	myeloperoxidase	Mus musculus	208-223
18998729-1	2008	The Et(3)N-assisted addition of beta-ketoester 3 to MVK in chloroform is catalyzed with high turnover efficiency by the phenyl-substituted uranyl-salophen compound 2b but not by the parent compound 1b.	Chloroform	59-69	mevalonate kinase	Homo sapiens	52-55
19032039-2	2008	The presence of a lipophilic dodecyl appendage at imidazolium nitrogen in 3 successfully allows the selective determination of AcO(-) ions in protic (CHCl(3)-MeOH, 1:1) solvent.	Chloroform	150-157	kallikrein related peptidase 15	Homo sapiens	127-130
21202516-0	2008	mu-Bis(diphenyl-phosphan-yl)borato-kappaP:P"-bis-[dicarbon-yl(eta-cyclo-penta-dien-yl)iron(II)] tetrachloridoferrate(III) chloro-form solvate.	Chloroform	122-133	endothelin receptor type A	Homo sapiens	62-65
18627523-1	2008	Under 254 or 313 nm irradiation in chloroform, [IrCl(CO)(PPh3)2] is converted cleanly to [IrCl2(CO)H(PPh3)2] through the addition of HCl, produced photochemically.	Chloroform	35-45	caveolin 1	Homo sapiens	57-61
18627523-1	2008	Under 254 or 313 nm irradiation in chloroform, [IrCl(CO)(PPh3)2] is converted cleanly to [IrCl2(CO)H(PPh3)2] through the addition of HCl, produced photochemically.	Chloroform	35-45	caveolin 1	Homo sapiens	101-105
18627523-2	2008	Under 254 nm irradiation, some of the reaction of [IrCl(CO)(PPh3)2] occurs by direct photolysis of chloroform, though a greater contribution arises from a reaction initiated through absorption of light by the metal complex.	Chloroform	99-109	caveolin 1	Homo sapiens	60-64
18627523-5	2008	Instead it is proposed that an association complex between excited state [IrCl(CO)(PPh3)2] and CHCl3 leads to dissociation of a chlorine atom from CHCl3, yielding HCl after abstraction of a hydrogen from another CHCl3.	Chloroform	95-100	caveolin 1	Homo sapiens	83-87
18627523-5	2008	Instead it is proposed that an association complex between excited state [IrCl(CO)(PPh3)2] and CHCl3 leads to dissociation of a chlorine atom from CHCl3, yielding HCl after abstraction of a hydrogen from another CHCl3.	Chloroform	147-152	caveolin 1	Homo sapiens	83-87
18627523-5	2008	Instead it is proposed that an association complex between excited state [IrCl(CO)(PPh3)2] and CHCl3 leads to dissociation of a chlorine atom from CHCl3, yielding HCl after abstraction of a hydrogen from another CHCl3.	Chloroform	147-152	caveolin 1	Homo sapiens	83-87
18729334-2	2008	Surface reactions of O2, CHCl3, and CCl4 on the Ag particles and bulk Ag(111) surfaces were studied by X-ray photoelectron spectroscopy (XPS), and it has been shown that size dependence of O2 and CHCl3 reactions on Ag differs from that of CCl4.	Chloroform	196-201	C-C motif chemokine ligand 4	Homo sapiens	36-40
18802629-9	2008	MD simulations in chloroform and acetonitrile boxes show that all molecules except DDDD adopt very similar conformations characterized by an up-down-up-down arrangement of the spacer groups.	Chloroform	18-28	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	83-87
18605682-2	2008	In the gas phase and in chloroform, the conformation tB with a trans depsipeptide bond is most preferred for the Lac dipeptide, whose backbone torsion angles are phi approximately -150 degrees and psi approximately -5 degrees , juxtaposed to those of the 3 10-helical structure.	Chloroform	24-34	lactase	Homo sapiens	113-116
18709138-5	2008	We determined posterior distributions for chloroform concentration in tap water and ambient household air using U.S. Environmental Protection Agency Total Exposure Assessment Methodology (TEAM) data as prior distributions for the Bayesian analysis.	Chloroform	42-52	nuclear RNA export factor 1	Homo sapiens	70-73
18709138-6	2008	RESULTS: Posterior distributions for exposure indicate that 95% of the population represented by the NHANES III data had likely chloroform exposures < or = 67 microg/L [corrected] in tap water and < or = 0.02 microg/L in ambient household air.	Chloroform	128-138	nuclear RNA export factor 1	Homo sapiens	186-189
18582016-3	2008	The beta-pleated conformer precipitates from solutions of DMSO-denatured insulin upon dilution with chloroform.	Chloroform	100-110	insulin	Homo sapiens	73-80
18204473-6	2008	KEY RESULTS: TRPC5 activation by carbachol, Gd3+ or LPC was inhibited by halothane and chloroform at > or =0.1 and 0.2 mM respectively.	Chloroform	87-97	transient receptor potential cation channel subfamily C member 5	Homo sapiens	13-18
18338874-4	2008	A net attraction is predicted for all four benzene complexes, whereas for the CHX3.C6F6 complexes, it was found that MP2/6-31G(d) predicts a net attraction for the CH4, CHCl3, and CHBr3 complexes and does not predict a stable complex for CHF3.C6F6.	Chloroform	169-174	major intrinsic protein of lens fiber	Homo sapiens	117-122
18204473-0	2008	Modulation of TRPC5 cation channels by halothane, chloroform and propofol.	Chloroform	50-60	transient receptor potential cation channel subfamily C member 5	Homo sapiens	14-19
18204473-3	2008	Here we report the effects of inhalational (halothane and chloroform) and intravenous (propofol) general anaesthetics upon TRPC5.	Chloroform	58-68	transient receptor potential cation channel subfamily C member 5	Homo sapiens	123-128
18294946-8	2008	Molecular mass measurement of intact recombinant NTS1 was performed using a mixture of chloroform/methanol/aqueous trifluoroacetic acid as the mobile phase for size exclusion chromatography-ESI-MS analysis.	Chloroform	87-97	neurotensin	Homo sapiens	49-53
18215046-3	2008	In addition, a one-pot RCM-isomerization reaction followed by cyclopropanation with CHCl3/NaOH allows the synthesis of products related to iNOS (nitric oxide synthase) inhibitors, which are currently under clinical evaluation.	Chloroform	84-89	nitric oxide synthase 2	Homo sapiens	139-143
17659831-3	2008	Photocatalytic decomposition of CCl4 may proceed via a two-electron transfer process that yields mainly CHCl3, Cl- and H2.	Chloroform	104-109	C-C motif chemokine ligand 4	Homo sapiens	32-36
17639562-0	2007	A steroid fraction of chloroform extract from bee pollen of Brassica campestris induces apoptosis in human prostate cancer PC-3 cells.	Chloroform	22-32	chromobox 8	Homo sapiens	123-127
18031782-5	2008	At a chloroform dose of 150 mg/kg, the levels of blood urea nitrogen (BUN) were five times higher in the exposed group than in the vehicle-treated one for the liver-Cpr-null mice, but they were only slightly higher in the exposed group than in the vehicle-treated group for the wild-type mice.	Chloroform	5-15	cytochrome p450 oxidoreductase	Mus musculus	165-168
18031782-7	2008	At a chloroform dose of 300 mg/kg, severe kidney lesions were observed in both strains, yet the BUN levels were still higher in the liver-Cpr-null than in the wild-type mice.	Chloroform	5-15	cytochrome p450 oxidoreductase	Mus musculus	138-141
18031782-8	2008	Higher chloroform levels were found in the tissues of the liver-Cpr-null mice.	Chloroform	7-17	cytochrome p450 oxidoreductase	Mus musculus	64-67
18350910-1	2008	Cytochrome P450 2E1 (CYP2E1) is a key enzyme in the mammalian metabolism of several low molecular weight volatile organic compounds (VOCs), such as trichloroethylene (TCE), vinyl chloride (VC), carbon tetrachloride (CT), benzene, chloroform, and bromodichloromethane (BDCM), which are all common environmental pollutants that pose risks to human health.	Chloroform	230-240	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-19
18350910-1	2008	Cytochrome P450 2E1 (CYP2E1) is a key enzyme in the mammalian metabolism of several low molecular weight volatile organic compounds (VOCs), such as trichloroethylene (TCE), vinyl chloride (VC), carbon tetrachloride (CT), benzene, chloroform, and bromodichloromethane (BDCM), which are all common environmental pollutants that pose risks to human health.	Chloroform	230-240	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	21-27
18173153-1	2007	OBJECTIVE: To observe the clinical effect of TCM treatment for dissolving phlegm and dispelling stasis (DP-DS) on acute cerebral infarction (ACI) and its influences on plasma protein C and S and soluble thrombomodulin (TM).	Chloroform	45-48	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	175-184
18173153-1	2007	OBJECTIVE: To observe the clinical effect of TCM treatment for dissolving phlegm and dispelling stasis (DP-DS) on acute cerebral infarction (ACI) and its influences on plasma protein C and S and soluble thrombomodulin (TM).	Chloroform	45-48	thrombomodulin	Homo sapiens	203-217
18173153-1	2007	OBJECTIVE: To observe the clinical effect of TCM treatment for dissolving phlegm and dispelling stasis (DP-DS) on acute cerebral infarction (ACI) and its influences on plasma protein C and S and soluble thrombomodulin (TM).	Chloroform	45-48	thrombomodulin	Homo sapiens	219-221
18792040-3	2008	However, spectrophotometric studies in CHCl3 solution have shown that only the poorly basic NO3 - ion is able to form authentic hydrogen-bond complexes with thiourea subunits, whereas all the other investigated anions (CH3COO-, NO2 -, F-) induce deprotonation of the N-H fragment.	Chloroform	39-44	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
17719596-1	2007	Amphiphilic colloids of CdS and noble metal nanoparticles, which can be dispersed both in water and organic solvents such as ethanol, N,N-dimethylformamide, chloroform, and toluene, are studied.	Chloroform	157-167	CDP-diacylglycerol synthase 1	Homo sapiens	24-27
17963866-7	2007	Docking analysis of rohitukine, the alkaloid isolated from active chloroform soluble fraction, to estrogen receptor (ERalpha) was conducted using AutoDock 3.0.5 on a Linux workstation.	Chloroform	66-76	estrogen receptor 1	Rattus norvegicus	98-115
17646068-4	2007	Chloroform extract (CE-C) of deer antler inhibited osteoclast differentiation in mouse bone marrow cultures stimulated by receptor activator of NF-kappaB ligand (RANKL) and macrophage-colony stimulating factor (M-CSF).	Chloroform	0-10	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	122-160
17918935-1	2007	This Article introduces a simple chemical model of a beta-sheet (artificial beta-sheet) that dimerizes by parallel beta-sheet formation in chloroform solution.	Chloroform	139-149	amyloid beta precursor protein	Homo sapiens	51-57
17914843-2	2007	1H NMR and fluorescence titrations revealed that receptors 2a and 2b, incorporating suitable positioned amine and oxime moieties, are able to form strong 1:1 complexes (Ka1 approximately 10(5) M-1) with dodecyl alpha- and beta-maltoside in chloroform solutions.	Chloroform	240-250	glutamate ionotropic receptor kainate type subunit 4	Homo sapiens	169-172
17728870-4	2007	The classical Carr-Price reaction between retinol (vitamin A) and the Lewis acid SbCl(3) in saturated chloroform solution was reinvestigated by VIS, NMR, EPR, dynamic light scattering and chemical quenching.	Chloroform	102-112	arrestin 3	Homo sapiens	14-18
17646068-4	2007	Chloroform extract (CE-C) of deer antler inhibited osteoclast differentiation in mouse bone marrow cultures stimulated by receptor activator of NF-kappaB ligand (RANKL) and macrophage-colony stimulating factor (M-CSF).	Chloroform	0-10	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	162-167
17646068-4	2007	Chloroform extract (CE-C) of deer antler inhibited osteoclast differentiation in mouse bone marrow cultures stimulated by receptor activator of NF-kappaB ligand (RANKL) and macrophage-colony stimulating factor (M-CSF).	Chloroform	0-10	colony stimulating factor 1 (macrophage)	Mus musculus	173-209
17646068-4	2007	Chloroform extract (CE-C) of deer antler inhibited osteoclast differentiation in mouse bone marrow cultures stimulated by receptor activator of NF-kappaB ligand (RANKL) and macrophage-colony stimulating factor (M-CSF).	Chloroform	0-10	colony stimulating factor 1 (macrophage)	Mus musculus	211-216
17764247-1	2007	Molecular association of chloroform with ammonia is studied by high-level quantum chemical calculations including correlated MP2 and CCSD(T) calculations with basis sets up to6-311++G(d,p) and counterpoise corrected energies, geometries, and frequencies.	Chloroform	25-35	tryptase pseudogene 1	Homo sapiens	125-128
17728215-9	2007	In vitro, expression of OGR1, but not GPR4, inhibited cell migration (mean percentage of cells migrated, 30.2% versus 100%, difference = 69.8%, 95% CI = 63.0% to 75.9%; P<.001) via increased expression of G alpha(i1) and the secretion of a chloroform/methanol-extractable heat-insensitive factor into the conditioned medium through a PTX-sensitive pathway.	Chloroform	243-253	G protein-coupled receptor 68	Mus musculus	24-28
17592598-5	2007	In chlorinated solvents such as dichloromethane or chloroform, [5]PF(6) rapidly abstracts chloride by reductive dechlorination of the solvent to yield [(TL(tBu))CuCl]PF6, [8]PF6 quantitatively.	Chloroform	51-61	sperm associated antigen 17	Homo sapiens	166-169
17622411-3	2007	It is shown that adding cs3 to a chloroform phase improves the solvation of all partners of the extraction system, i.e. the free calixarene ligand L, its LCs(+) complex and its counterion.	Chloroform	33-43	myozenin 3	Homo sapiens	24-27
17622411-9	2007	twice as small in the cs3-modified solution than in a pure chloroform phase.	Chloroform	59-69	myozenin 3	Homo sapiens	22-25
17592598-5	2007	In chlorinated solvents such as dichloromethane or chloroform, [5]PF(6) rapidly abstracts chloride by reductive dechlorination of the solvent to yield [(TL(tBu))CuCl]PF6, [8]PF6 quantitatively.	Chloroform	51-61	sperm associated antigen 17	Homo sapiens	174-177
17202693-1	2007	In our investigation on the chemical constituents of Hippophae rhamnoides L., the chloroform-soluble fraction of the 80% acetone extract of branch bark was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide and recombinant mouse interferon-gamma-activated murine macrophage-like cell line, RAW 264.7 cells.	Chloroform	82-92	interferon gamma	Mus musculus	251-267
17547394-14	2007	A molecular association was observed between chloroform and oxomolybdenum(V) corrole 1 through MoO...H/CCl3 hydrogen-bonding interactions.	Chloroform	45-55	C-C motif chemokine ligand 3	Homo sapiens	103-107
17663194-6	2007	All of the solvent fractions significantly suppressed NO production in RAW264.7 cells induced by lipopolysaccharide (LPS, 0.1 microg/ml) and of the fractions, only the chloroform (CHC) fraction completely blocked the expression of inducible NO synthase (iNOS).	Chloroform	168-178	nitric oxide synthase 2, inducible	Mus musculus	231-252
17663194-6	2007	All of the solvent fractions significantly suppressed NO production in RAW264.7 cells induced by lipopolysaccharide (LPS, 0.1 microg/ml) and of the fractions, only the chloroform (CHC) fraction completely blocked the expression of inducible NO synthase (iNOS).	Chloroform	168-178	nitric oxide synthase 2, inducible	Mus musculus	254-258
17438791-6	2007	Lowering the temperature from 40 to 30 degrees C resulted in a decreased average chloroform yield from 0.50 to 0.37 mol chloroform/mol triclosan consumed after 1 min of reaction time for an initial free chlorine concentration of 4.0 mg/L as Cl2.	Chloroform	81-91	endogenous retrovirus group W member 5	Homo sapiens	241-244
17438791-6	2007	Lowering the temperature from 40 to 30 degrees C resulted in a decreased average chloroform yield from 0.50 to 0.37 mol chloroform/mol triclosan consumed after 1 min of reaction time for an initial free chlorine concentration of 4.0 mg/L as Cl2.	Chloroform	120-130	endogenous retrovirus group W member 5	Homo sapiens	241-244
17438791-7	2007	At 40 degrees C the average molar chloroform yields decreased to 0.29 and <0.1 when the initial free chlorine concentration was decreased to either 2.0 or 1.0 mg/L as Cl2, respectively.	Chloroform	34-44	endogenous retrovirus group W member 5	Homo sapiens	170-173
17348850-2	2007	Both the chloroform and hexane fractions and a few of their sub-fractions showed moderate to very good activity against P388, HL60 and LL2 cancer cell lines.	Chloroform	9-19	peroxiredoxin 2, pseudogene 1	Mus musculus	135-138
17269773-1	2007	Reversible coordination networks were prepared by combining diphenylphosphinite telechelic polytetrahydrofuran (2) with [RhCl(COD)]2 or [IrCl(COD)]2 in chloroform.	Chloroform	152-162	COD2	Homo sapiens	136-148
17559452-4	2007	DNA was extracted from all 40 individuals; the polymerase chain reaction (PCR) for MSX1 was carried out with Phenol: Chloroform: Isoamylalchol (PCI) extraction method.	Chloroform	117-127	msh homeobox 1	Homo sapiens	83-87
17456423-11	2007	Best adsorption properties for TNT vapour until now showed a PAA-MIP synthesized with chloroform.	Chloroform	86-96	chromosome 16 open reading frame 82	Homo sapiens	31-34
17091496-4	2007	An analog of peptide 1 with an Aib-Gly turn-nucleated hairpin (Boc-W-L-W-U-G-W-L-W-OMe (peptide 2)) shows a preference for helical structures in solution, in both chloroform and methanol.	Chloroform	163-173	ANIB1	Homo sapiens	31-34
16980512-7	2007	A soluble proinflammatory substance was separated from the bacterial recombinant HMGB1 by chloroform-methanol treatment.	Chloroform	90-100	high mobility group box 1	Homo sapiens	81-86
16574409-3	2006	Degradation of benzene ring of NP-10 was studied using UV-absorbance at 277 nm in chloroform.	Chloroform	82-92	nuclear receptor subfamily 4 group A member 1	Homo sapiens	31-36
17168610-2	2006	It was found that for N-protected indoles the reaction proceeded smoothly in the presence of 5 mol % of Pd(acac)2 and 10 mol % of PPh3 at 80 degrees C in HOAc, while for N-unprotected indoles, the reaction was carried out by using 5 mol % of Pd(dba)2 or 2.5 mol % of Pd2(dba)3.CHCl3 with 10 mol % of 2,2"-bipyridine as the catalyst in toluene.	Chloroform	277-282	caveolin 1	Homo sapiens	130-134
17954255-4	2007	The lipid phosphate phosphatase activities of DPP1-encoded and LPP1-encoded enzymes are measured by following the release of water-soluble radioactive inorganic phosphate from chloroform-soluble radioactive lipid phosphate substrate following a chloroform/methanol/water phase partition.	Chloroform	176-186	bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase	Saccharomyces cerevisiae S288C	46-50
17954255-4	2007	The lipid phosphate phosphatase activities of DPP1-encoded and LPP1-encoded enzymes are measured by following the release of water-soluble radioactive inorganic phosphate from chloroform-soluble radioactive lipid phosphate substrate following a chloroform/methanol/water phase partition.	Chloroform	176-186	phosphatidate phosphatase LPP1	Saccharomyces cerevisiae S288C	63-67
17954255-4	2007	The lipid phosphate phosphatase activities of DPP1-encoded and LPP1-encoded enzymes are measured by following the release of water-soluble radioactive inorganic phosphate from chloroform-soluble radioactive lipid phosphate substrate following a chloroform/methanol/water phase partition.	Chloroform	245-255	bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase	Saccharomyces cerevisiae S288C	46-50
17954255-4	2007	The lipid phosphate phosphatase activities of DPP1-encoded and LPP1-encoded enzymes are measured by following the release of water-soluble radioactive inorganic phosphate from chloroform-soluble radioactive lipid phosphate substrate following a chloroform/methanol/water phase partition.	Chloroform	245-255	phosphatidate phosphatase LPP1	Saccharomyces cerevisiae S288C	63-67
17489406-7	2007	Water samples stored in the epoxy-lined pipes showed a significant increase in the leaching of organic compounds (as TOC), and this TOC was demonstrated to react with free chlorine to form trichloromethane.	Chloroform	189-205	rhomboid 5 homolog 2	Homo sapiens	132-135
17165934-1	2006	[Structure: see text] Photocatalytic carbon-carbon bond formation of 9,10-dimethylanthracene (DMA) in chloroform occurs efficiently via the electron-transfer oxidation of DMA with the photoinduced electron-transfer state of 9-mesityl-10-methylacridinium ion (Acr+-Mes), followed by deprotonation from the methyl group of DMA radical cation and the radical coupling reaction between anthracenylmethyl radicals to produce dimethyllepidopterene.	Chloroform	102-112	acrosin	Homo sapiens	259-262
17029470-2	2006	The CCl2 parent molecule was generated in a molecular beam by pyrolysis of CHCl3, and both CCl2 and the CCl photofragment were detected by laser fluorescence excitation.	Chloroform	75-80	C-C motif chemokine ligand 2	Homo sapiens	4-8
16879906-8	2006	Exposure to styrene or chloroform alone slightly increased Th2 cytokine production by lung-draining lymph node cells cultured with concanavaline A, except for the IL-4 level in the chloroform exposure group, which decreased.	Chloroform	23-33	heart and neural crest derivatives expressed 2	Mus musculus	59-62
16815507-8	2006	Kidney GSH and glutathione reductase activity were upregulated, with a concomitant reduction in oxidized glutathione in the primed mice following lethal dose challenge, leading to decreased renal covalent binding of (14)C-chloroform-derived radiolabel, in the absence of any change in CYP2E1 levels.	Chloroform	222-232	glutathione reductase	Mus musculus	15-36
16647228-0	2006	In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform.	Chloroform	63-78	potassium voltage-gated channel subfamily H member 2	Homo sapiens	23-27
16647228-5	2006	To further investigate the electrophysiological basis of the arrhythmogenic potential of chloroform, we analysed inhibitory effects of chloroform on cloned HERG potassium channels, heterologously expressed in Xenopus oocytes and in Human Embryonic Kidney (HEK 293) cells using the double-electrode voltage-clamp technique and the whole-cell patch-clamp technique, respectively.	Chloroform	135-145	potassium voltage-gated channel subfamily H member 2	Homo sapiens	156-160
16647228-6	2006	In HEK cells, chloroform blocked HERG tail currents with an IC(50) of 4.97mM.	Chloroform	14-24	potassium voltage-gated channel subfamily H member 2	Homo sapiens	33-37
16647228-0	2006	In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform.	Chloroform	133-143	potassium voltage-gated channel subfamily H member 2	Homo sapiens	23-27
16647228-11	2006	Chloroform dependent block of HERG channels was voltage dependent with a decrease of inhibition at more positive membrane potentials.	Chloroform	0-10	potassium voltage-gated channel subfamily H member 2	Homo sapiens	30-34
16878909-2	2006	Complexation of CsF with the ditopic uranyl-salen receptor results in a solid-state structure, in which the coordination sphere of cesium is filled by ligation to one of the chlorine atoms of the solvent chloroform.	Chloroform	204-214	colony stimulating factor 2	Homo sapiens	16-19
16647228-13	2006	In summary, chloroform blocked HERG potassium channels probably in a toxicologically relevant concentration.	Chloroform	12-22	potassium voltage-gated channel subfamily H member 2	Homo sapiens	31-35
16819213-2	2006	These methods are based on the formation of chloroform soluble ion-association complexes of TRH with bromothymol blue (BTB) and with bromocresol purple (BCP) in KCl-HCl buffer of pH 2.0 (for BTB) and in NaOAc-AcOH buffer of pH of 3.6 (for BCP) with absorption maximum at 423 nm and at 408 nm for BTB and BCP, respectively.	Chloroform	44-54	opsin 1, short wave sensitive	Homo sapiens	153-156
16885125-6	2006	Pegylated IFN alpha encapsulated multivesicular liposomes were prepared by double emulsification technique followed by evaporation of organic solvents from chloroform ether spherules suspended in water.	Chloroform	156-166	interferon alpha 2	Homo sapiens	10-19
16819223-1	2006	In vitro anti-allergic screening of medicinal herbal extracts revealed that the chloroform extract of the rhizoma of Kadsura coccinea inhibited nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage like cell line RAW 264.7.	Chloroform	80-90	interferon gamma	Mus musculus	225-241
16819223-1	2006	In vitro anti-allergic screening of medicinal herbal extracts revealed that the chloroform extract of the rhizoma of Kadsura coccinea inhibited nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage like cell line RAW 264.7.	Chloroform	80-90	interferon gamma	Mus musculus	243-252
16885125-8	2006	In process stability studies of pegylated IFN alpha protein exhibited better stability when exposed to chloroform: diethyl ether (1:1 ratio) mixture as well as variable vortexing time as compared to native IFN alpha.	Chloroform	103-113	interferon alpha 2	Homo sapiens	42-51
16734465-3	2006	Unexpectedly, the receptor shows completely different binding modes in chlorobenzene and CHCl3/CS2 mixtures.	Chloroform	89-94	chorionic somatomammotropin hormone 2	Homo sapiens	95-98
16581538-9	2006	For chloroform from showering, strong correlations were observed for indoor air and exhaled breath, blood and exhaled breath, indoor air and blood, and tap water and blood.	Chloroform	4-14	nuclear RNA export factor 1	Homo sapiens	152-155
16584636-10	2006	On the contrary, the levels of antioxidant enzymes such as catalase, superoxide dismutase and glutathione-S-transferase that had gone down in mice orally fed with chloroform were significantly elevated in protein pretreated ones.	Chloroform	163-173	catalase	Mus musculus	59-67
16584636-10	2006	On the contrary, the levels of antioxidant enzymes such as catalase, superoxide dismutase and glutathione-S-transferase that had gone down in mice orally fed with chloroform were significantly elevated in protein pretreated ones.	Chloroform	163-173	hematopoietic prostaglandin D synthase	Mus musculus	94-119
15978860-6	2006	Chemical oxidation of CuL2x with (NH4)2[Ce(NO3)6] in CHCl3 and MeCN solutions at 300 K affords gradually disappearance of their ESR signals and dramatic changes in the electronic spectra as well as the appearance of new maximum bands at 530-672 (CHCl3) and 670-700 nm (MeCN), suggesting generation of Cu(II)-phenoxyl radical species.	Chloroform	53-58	cullin 2	Homo sapiens	22-26
16490389-4	2006	The appearance of this complex could be explained having in mind donor-acceptor properties of complexes, solvents and the resultant reaction of Cu(octxant)2 with the ester of diselenocarbamic acid yielded in Cu(Et2dsc)2 destruction by CCl4 or CHCl3.	Chloroform	243-248	C-C motif chemokine ligand 4	Homo sapiens	235-239
16542568-2	2006	The Fourier transform infrared (FT-IR) spectra of the enzyme obtained in chloroform, methanol, and acetonitrile showed an absorption band at 1617 cm(-1) indicative of significant protein aggregation, whereas spectra of lipoxygenase in hexane and octane exhibited substantially less aggregate formation.	Chloroform	73-83	linoleate 9S-lipoxygenase-4	Glycine max	219-231
15978860-6	2006	Chemical oxidation of CuL2x with (NH4)2[Ce(NO3)6] in CHCl3 and MeCN solutions at 300 K affords gradually disappearance of their ESR signals and dramatic changes in the electronic spectra as well as the appearance of new maximum bands at 530-672 (CHCl3) and 670-700 nm (MeCN), suggesting generation of Cu(II)-phenoxyl radical species.	Chloroform	246-251	cullin 2	Homo sapiens	22-26
16154195-2	2006	The most dominant THM compounds are chloroform, bromodichloromethane (BDCM), and dibromochloromethane (DBCM) in Istanbul tap water.	Chloroform	36-46	nuclear RNA export factor 1	Homo sapiens	121-124
16154195-5	2006	The lifetime cancer risks of chloroform, BDCM, and DBCM from tap water of all 15 districts were higher than 10(-6), the negligible risk level defined by the USEPA.	Chloroform	29-39	nuclear RNA export factor 1	Homo sapiens	61-64
16931441-5	2006	Treatment of the cells with CHCl3 decreased cellular viability and increased GPT and LDH.	Chloroform	28-33	glutamic--pyruvic transaminase	Homo sapiens	77-80
16873089-5	2006	The percentage change in ex vivo-induced level of inflammatory cytokine IL-18 was significantly lower in the TCM group than in the placebo group after taking the capsules for 24 weeks (p < 0.05).	Chloroform	109-112	interleukin 18	Homo sapiens	72-77
16931441-6	2006	Cells treated with the protein before and immediately after CHCl3 application showed a marked improvement in their viability and reduced leakage of GPT and LDH.	Chloroform	60-65	glutamic--pyruvic transaminase	Homo sapiens	148-151
16931441-7	2006	The levels of CAT and GSH, which were diminished in cells treated with CHCl3, were restored by protein treatment.	Chloroform	71-76	catalase	Homo sapiens	14-17
20050553-6	2006	Transformation into CCl4 was also detected for CHCl3 decomposition reaction.	Chloroform	47-52	C-C motif chemokine ligand 4	Homo sapiens	20-24
16122163-1	2005	This work proposes a new method for Co(II) determination based on the use of the triblock copolymer as micellar medium instead of chloroform.	Chloroform	130-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
16393471-11	2006	In addition, chloroform and ethyl acetate fractions significantly blocked the expression of inducible nitric oxide synthetase (iNOS) and interleukin-6 (IL-6) from the RAW264.7 cells stimulated by LPS.	Chloroform	13-23	interleukin 6	Mus musculus	137-150
16393471-11	2006	In addition, chloroform and ethyl acetate fractions significantly blocked the expression of inducible nitric oxide synthetase (iNOS) and interleukin-6 (IL-6) from the RAW264.7 cells stimulated by LPS.	Chloroform	13-23	interleukin 6	Mus musculus	152-156
16288619-4	2005	Later, the Boer Wars (1899-1902) helped stabilise the popularity of chloroform after the Hyderabad Commissions but were of little experimental value to anaesthesia.	Chloroform	68-78	tryptophanyl-tRNA synthetase 1	Homo sapiens	16-20
16212342-3	2005	When grown in chloroform, 1 displays an octahedral coordination around Co(II), resulting in a 2D coordination network.	Chloroform	14-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
16146375-3	2005	Chloroform is essential for this reaction, and palladium complex that was prepared from Pd(PPh3)4 with CHCl3 showed good catalytic acitivity as well.	Chloroform	0-10	caveolin 1	Homo sapiens	91-95
16146375-3	2005	Chloroform is essential for this reaction, and palladium complex that was prepared from Pd(PPh3)4 with CHCl3 showed good catalytic acitivity as well.	Chloroform	103-108	caveolin 1	Homo sapiens	91-95
15848114-4	2005	The first-order degradation rate constants and the sonolysis efficiencies followed the decreasing order of CHCl3 > CHBrCl2 > CHBr2Cl > CHBr3 > CHI3.	Chloroform	107-112	chitinase 1	Homo sapiens	155-159
16124297-3	2005	In the present study, the abiotic dehalogenation of CCl4 by Fe(II) present at the surface of different iron minerals has been characterized in terms of the reaction rates and carbon isotopic fractionation (delta13C) of carbon tetrachloride (CCl4) as well as the yields and isotopic signatures of chloroform (CHCl3), one of the main transformation products.	Chloroform	296-306	C-C motif chemokine ligand 4	Homo sapiens	52-56
16124297-3	2005	In the present study, the abiotic dehalogenation of CCl4 by Fe(II) present at the surface of different iron minerals has been characterized in terms of the reaction rates and carbon isotopic fractionation (delta13C) of carbon tetrachloride (CCl4) as well as the yields and isotopic signatures of chloroform (CHCl3), one of the main transformation products.	Chloroform	308-313	C-C motif chemokine ligand 4	Homo sapiens	52-56
15914208-6	2005	Comparison of the in vivo response of the luciferase reporter with markers of toxicity measured ex vivo (differential gene expression of adaptive antioxidant response genes, clinical chemistry and microscopic examination) confirms the gender-specific difference in chloroform renal toxicity in HO-1.luc transgenic mice and its reversal following androgenisation of females and correlates with the expression of the endogenous haem oxygenase-1 (HO-1) gene.	Chloroform	265-275	heme oxygenase 1	Mus musculus	426-449
16025433-2	2005	Chloroform targets the liver in humans, where cytochrome P-450-dependent biotransformation to phosgene results in mitochondrial damage and cell death.	Chloroform	0-10	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	46-62
15984786-6	2005	Chloroform (CHCl3), the major chlorinated product in CCl4 dechlorination, accumulated at a concentration up to 13 microM in the GR(Cl) system alone, but was completely dechlorinated within 9 h in the GR(Cl)-Cu(II) suspension.	Chloroform	0-10	C-C motif chemokine ligand 4	Homo sapiens	53-57
15984786-6	2005	Chloroform (CHCl3), the major chlorinated product in CCl4 dechlorination, accumulated at a concentration up to 13 microM in the GR(Cl) system alone, but was completely dechlorinated within 9 h in the GR(Cl)-Cu(II) suspension.	Chloroform	12-17	C-C motif chemokine ligand 4	Homo sapiens	53-57
15869269-4	2005	These findings underlie the presence of specific, oriented interactions between the ionic liquid, 1-alkyl-3-methylimidazolium bis{(trifluoromethyl)sulfonyl}amide, [Cnmim][NTf2], and trichloromethane, as well as aggregation phenomena.	Chloroform	182-198	nuclear transport factor 2	Homo sapiens	171-175
15913136-1	2005	A chloroform membrane system containing a given mixture of ketoconazole and oleic acid was applied for the uphill transport of Cd2+ ions as CdI42-.	Chloroform	2-12	CD2 molecule	Homo sapiens	127-130
15867250-1	2005	PURPOSE: In this study, we have examined the antitumor effects of chloroform extract of Angelica sinensis (AS-C), a traditional Chinese medicine, on glioblastoma multiforme (GBM) brain tumors in vitro and in vivo.	Chloroform	66-76	PYD and CARD domain containing	Rattus norvegicus	107-111
15605154-1	2005	Reactions of the halides X- (X- = chloride, bromide or iodide) with the substituted cluster Rh6(CO)15(PPh3) in oxygen-free chloroform lead to [Rh5(CO)14(PPh3)]-, Rh(CO)2(PPh3)2X and [Rh(CO)2X2]- in the molar ratios 2:1: approximately 13.	Chloroform	123-133	protein phosphatase 4 catalytic subunit	Homo sapiens	102-106
15845001-4	2005	The free energies derived from the syn/anti ratios in chloroform range from slightly positive (0.2 kcal/mol) to considerably negative (-0.98 kcal mol) values.	Chloroform	54-64	synemin	Homo sapiens	35-38
15740765-4	2005	Similar to previous findings, the winter chloroform concentration in tap water treated with chlorine (22.1 microg/l, median) was significantly higher than that in the tap water treated with ozone-chlorine (16.8 microg/l, median).	Chloroform	41-51	nuclear RNA export factor 1	Homo sapiens	69-72
15632970-1	2005	Boc-protected L-phenylalanine has been connected to a spacer-armed ureido-acetic acid derivative, which can form multiple supramolecular complexes with urea-adamantyl modified poly(propylene imine) dendrimers in chloroform.	Chloroform	212-222	BOC cell adhesion associated, oncogene regulated	Homo sapiens	0-3
15757336-8	2005	Previous work has shown that CHCl3 can be generated either through hydrogen abstraction by a trichloromethyl radical (radical CCl3), or through proton abstraction by the trichlorocarbanion (-:CCl3).	Chloroform	29-34	C-C motif chemokine ligand 3	Homo sapiens	126-130
15757336-8	2005	Previous work has shown that CHCl3 can be generated either through hydrogen abstraction by a trichloromethyl radical (radical CCl3), or through proton abstraction by the trichlorocarbanion (-:CCl3).	Chloroform	29-34	C-C motif chemokine ligand 3	Homo sapiens	192-196
15605154-1	2005	Reactions of the halides X- (X- = chloride, bromide or iodide) with the substituted cluster Rh6(CO)15(PPh3) in oxygen-free chloroform lead to [Rh5(CO)14(PPh3)]-, Rh(CO)2(PPh3)2X and [Rh(CO)2X2]- in the molar ratios 2:1: approximately 13.	Chloroform	123-133	protein phosphatase 4 catalytic subunit	Homo sapiens	153-157
15605154-1	2005	Reactions of the halides X- (X- = chloride, bromide or iodide) with the substituted cluster Rh6(CO)15(PPh3) in oxygen-free chloroform lead to [Rh5(CO)14(PPh3)]-, Rh(CO)2(PPh3)2X and [Rh(CO)2X2]- in the molar ratios 2:1: approximately 13.	Chloroform	123-133	protein phosphatase 4 catalytic subunit	Homo sapiens	153-157
18969645-9	2004	Low levels of dichloromethane and chloroform ranging from 0.04 to 1.13mugg(-1) were found in samples obtained from small gardens irrigated with tap water.	Chloroform	34-44	nuclear RNA export factor 1	Homo sapiens	144-147
15514851-2	2004	This study was designed to characterize the protective effects of the chloroform fraction of the ethanol extract of T. catappa leaves (TCCE) against carbon tetrachloride (CCl4)-induced hepatotoxicity in mice, and analyze the changes in expression level of interleukin-6 (IL-6) in the process.	Chloroform	70-80	chemokine (C-C motif) ligand 4	Mus musculus	171-175
15262451-0	2004	A simple stopped assay for fatty acid amide hydrolase avoiding the use of a chloroform extraction phase.	Chloroform	76-86	fatty acid amide hydrolase	Homo sapiens	27-53
15262451-4	2004	It is concluded that the acidic charcoal extraction method provides a robust and simple stopped assay for FAAH without the need to use potentially hazardous solvents like chloroform.	Chloroform	171-181	fatty acid amide hydrolase	Homo sapiens	106-110
15123558-7	2004	To confirm that this is reflected in a different current density, whole cell TREK-1 currents, activated by chloroform, were recorded with patch clamp techniques in epicardial and endocardial cells.	Chloroform	107-117	potassium two pore domain channel subfamily K member 2	Rattus norvegicus	77-83
15323522-3	2004	The self-assembled films were prepared by immersing the mica in dilute chloroform or tetrahydrofuran (THF) solutions.	Chloroform	71-81	MHC class I polypeptide-related sequence A	Homo sapiens	56-60
15308043-2	2004	METHODS: Using genomic DNA extracted with phenol:chloroform:isoamyl alcohol from the blood of 94 healthy smokers and 88 COPD smokers, three single nucleotide polymorphism (SNP) sites in IL-13 gene marked as 1103C/T, 4257G/A, 4738G/A were determined by polymerase chain reaction/restriction fragment length polymorphism analysis or polymerase chain reaction/single strand conformation analysis.	Chloroform	49-59	interleukin 13	Homo sapiens	186-191
15267966-0	2004	Mass spectrometry study of the fragmentation of valence and core-shell (Cl 2p) excited CHCl3 and CDCl3 molecules.	Chloroform	87-92	endogenous retrovirus group W member 5	Homo sapiens	72-77
15120965-9	2004	For instance, carbon tetrachloride and chloroform treatments were found to decrease the expression of the cytochrome P450 isoform 3A1 gene while enhancing the expression of the multiple drug resistance gene MDR1 in liver, clearly demonstrating that the CYP3A1 and MDR1 genes were not co-regulated as postulated by some researchers.	Chloroform	39-49	ATP binding cassette subfamily B member 1	Homo sapiens	207-211
15120965-9	2004	For instance, carbon tetrachloride and chloroform treatments were found to decrease the expression of the cytochrome P450 isoform 3A1 gene while enhancing the expression of the multiple drug resistance gene MDR1 in liver, clearly demonstrating that the CYP3A1 and MDR1 genes were not co-regulated as postulated by some researchers.	Chloroform	39-49	ATP binding cassette subfamily B member 1	Homo sapiens	264-268
15129551-5	2004	However, the Michaelis-Menten rate constants for CHCl3 oxidation have not been derived in vitro, and the specific activity of CYP2E1 toward CHCl3 has not been reported.	Chloroform	140-145	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	126-132
14961569-10	2004	Finally, we show suppression of PKR activity was still present following ultrafilitration through a 10,000 Da cutoff filter but was lost upon extraction with phenol/chloroform or by high salt washing.	Chloroform	165-175	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	32-35
15129551-0	2004	The metabolic rate constants and specific activity of human and rat hepatic cytochrome P-450 2E1 toward toluene and chloroform.	Chloroform	116-126	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	76-96
15129551-3	2004	The metabolism of CHCl3 is via cytochrome P-450 2E1 (CYP2E1)-mediated oxidation to phosgene, which is known to obey a saturable mechanism.	Chloroform	18-23	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	31-51
15129551-3	2004	The metabolism of CHCl3 is via cytochrome P-450 2E1 (CYP2E1)-mediated oxidation to phosgene, which is known to obey a saturable mechanism.	Chloroform	18-23	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	53-59
15129551-7	2004	The specific activity of CYP2E1 toward CHCl3 in rats and humans was 5.29 and 5.24 pmol/min/pmol CYP2E1, respectively.	Chloroform	39-44	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	25-31
15129551-7	2004	The specific activity of CYP2E1 toward CHCl3 in rats and humans was 5.29 and 5.24 pmol/min/pmol CYP2E1, respectively.	Chloroform	39-44	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	96-102
15129551-8	2004	Toluene metabolism to benzyl alcohol (BA), another CYP2E1-dependent reaction, was also highly dependent on CYP2E1 content in humans, and was more efficient than was CHCl3 metabolism.	Chloroform	165-170	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	51-57
15129551-10	2004	These results demonstrate that differences in CYP2E1 content of MSP among individuals and between species are largely responsible for observed differences in toluene and CHCl3 metabolism in vitro.	Chloroform	170-175	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	46-52
15049622-2	2004	In CHCl(3) both, anti- and syn-squaramide rotamers are observed by NMR.	Chloroform	3-10	synemin	Homo sapiens	27-30
15112807-3	2004	We investigated mechanisms and product formation of CCl4 reduction by Fe(II) sorbed to goethite, which may lead to completely dehalogenated products or to chloroform (CHCl3), a toxic product which is fairly persistent under anoxic conditions.	Chloroform	155-165	C-C motif chemokine ligand 4	Homo sapiens	52-56
15112807-3	2004	We investigated mechanisms and product formation of CCl4 reduction by Fe(II) sorbed to goethite, which may lead to completely dehalogenated products or to chloroform (CHCl3), a toxic product which is fairly persistent under anoxic conditions.	Chloroform	167-172	C-C motif chemokine ligand 4	Homo sapiens	52-56
15112807-4	2004	A simultaneous transfer of two electrons and cleavage of two C-Cl bonds of CCl4 would completely circumvent chloroform production.	Chloroform	108-118	C-C motif chemokine ligand 4	Homo sapiens	75-79
15112807-7	2004	At pH 7, reduction of CCl4 by Fe(II)/ goethite produced approximately 33% CHCl3, 20% carbon monoxide (CO), and up to 40% formate (HCOO-).	Chloroform	74-79	C-C motif chemokine ligand 4	Homo sapiens	22-26
15112807-8	2004	Addition of 2-propanol-d8 resulted in 33% CDCl3 and only 4% CO, indicating that both products were generated from trichloromethyl radicals (*CCl3), chloroform by reaction with hydrogen radical donors and CO by an alternative pathway likely to involve surface-bound intermediates.	Chloroform	114-138	C-C motif chemokine ligand 3	Homo sapiens	141-145
15112807-8	2004	Addition of 2-propanol-d8 resulted in 33% CDCl3 and only 4% CO, indicating that both products were generated from trichloromethyl radicals (*CCl3), chloroform by reaction with hydrogen radical donors and CO by an alternative pathway likely to involve surface-bound intermediates.	Chloroform	148-158	C-C motif chemokine ligand 3	Homo sapiens	141-145
14962510-5	2004	Results showed that chloroform extract (CE) and ethanol extract (EE) from cigarette smoke dose-dependently stimulated gastric cancer cell proliferation, which was accompanied with an activation of ornithine decarboxylase (ODC) activity, COX-2, and c-myc expressions.	Chloroform	20-30	ornithine decarboxylase 1	Homo sapiens	197-220
14962510-5	2004	Results showed that chloroform extract (CE) and ethanol extract (EE) from cigarette smoke dose-dependently stimulated gastric cancer cell proliferation, which was accompanied with an activation of ornithine decarboxylase (ODC) activity, COX-2, and c-myc expressions.	Chloroform	20-30	prostaglandin-endoperoxide synthase 2	Homo sapiens	237-242
14744530-9	2004	GAL, AR, and NR activities were significantly different after treatment with bromate, chloroform, BDCM, and MX, but not the mixture.	Chloroform	86-96	galactosidase, beta 1	Rattus norvegicus	0-3
14643286-2	2004	The most dominant THMs are chloroform and bromodichloromethane (BDCM) in Hong Kong tap water.	Chloroform	27-37	nuclear RNA export factor 1	Homo sapiens	83-86
14744530-9	2004	GAL, AR, and NR activities were significantly different after treatment with bromate, chloroform, BDCM, and MX, but not the mixture.	Chloroform	86-96	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	5-7
14750886-8	2004	Analysis of tap water, spiked with chloroform or carbon tetrachloride, gave recoveries within 1.0-2.6% of the recoveries by the standard GC method.	Chloroform	35-45	nuclear RNA export factor 1	Homo sapiens	12-15
15468919-4	2004	The pKO-HPRT was linearized by Not I, extracted by ethidium bromide, butanol and phenol/chloroform, and dialyzed by 0.025 microlmol/L Millipore.	Chloroform	88-98	hypoxanthine phosphoribosyltransferase 1	Rattus norvegicus	8-12
12636402-1	2003	Activity-monitored fractionation of a CHCl(3)-soluble extract of Deprea subtriflora using a quinone reductase induction assay led to the purification of subtrifloralactones A-J (1-10), 10 novel C-18 norwithanolides based on a new C(27) skeleton.	Chloroform	38-45	crystallin, zeta	Mus musculus	92-109
14705028-3	2004	In simulations in chloroform, the Hao-containing peptide 9 (i-PrCO-Phe-Hao-Val-NHBu) forms a beta-sheet-like hydrogen-bonded dimer, in good agreement with the available experimental data.	Chloroform	18-28	amyloid beta precursor protein	Homo sapiens	91-97
14705028-5	2004	MD simulations also reproduce the folding of the synthetic peptide 1a (i-PrCO-Hao-Ut-Phe-Ile-Leu-NHMe) into a beta-hairpin-like structure in chloroform.	Chloroform	141-151	amyloid beta precursor protein	Homo sapiens	108-114
15617504-0	2003	[Hepatoprotective effects of chloroform extract from leaf of Terminalia catappa in relation to the inhibition of liver IL-6 expression].	Chloroform	29-39	interleukin 6	Mus musculus	119-123
12727595-5	2003	The correlation between simulated uptakes and home tap chloroform concentration was 0.6.	Chloroform	55-65	nuclear RNA export factor 1	Homo sapiens	51-54
12708612-4	2003	CCl4 is activated by cytochrome (CYP)2E1, CYP2B1 or CYP2B2, and possibly CYP3A, to form the trichloromethyl radical, CCl3*.	Chloroform	92-115	C-C motif chemokine ligand 4	Homo sapiens	0-4
12505447-0	2003	Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury.	Chloroform	69-79	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	23-28
12584152-11	2003	The role of human CYP2E1 in CHCl(3) metabolism at low levels, typical of actual human exposure, provides insight into the molecular basis for eventual difference in susceptibility to chloroform-induced effects due to either genetic, pathophysiological, or environmental factors.	Chloroform	28-35	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	18-24
12584152-11	2003	The role of human CYP2E1 in CHCl(3) metabolism at low levels, typical of actual human exposure, provides insight into the molecular basis for eventual difference in susceptibility to chloroform-induced effects due to either genetic, pathophysiological, or environmental factors.	Chloroform	183-193	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	18-24
12609614-4	2003	The most suitable system is based on reagent VIII (pH 7.5) with chloroform as the extraction solvent.	Chloroform	64-74	cytochrome c oxidase subunit 8A	Homo sapiens	45-49
12708612-4	2003	CCl4 is activated by cytochrome (CYP)2E1, CYP2B1 or CYP2B2, and possibly CYP3A, to form the trichloromethyl radical, CCl3*.	Chloroform	92-115	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	73-78
12708612-4	2003	CCl4 is activated by cytochrome (CYP)2E1, CYP2B1 or CYP2B2, and possibly CYP3A, to form the trichloromethyl radical, CCl3*.	Chloroform	92-115	C-C motif chemokine ligand 3	Homo sapiens	117-121
12220494-2	2002	GC/MS and NMR analysis of chloroform/methanol extracts from purified HNF4alpha and HNF4gamma LBDs identified mixtures of saturated and cis-monounsaturated C14-18 fatty acids.	Chloroform	26-36	hepatocyte nuclear factor 4 alpha	Homo sapiens	69-78
12595880-5	2003	Chloroform was the predominant THM in all water types apart from the ground water of one supplier.	Chloroform	0-10	THM	Homo sapiens	31-34
12368294-8	2002	TLC analysis of (14)C-labeled bile acids synthesized in cells overexpressing StAR showed a 5-fold increase in muricholic acid; in chloroform-extractable products, a dramatic increase was seen in bile acid biosynthesis intermediates (27- and 7,27-hydroxycholesterol).	Chloroform	130-140	steroidogenic acute regulatory protein	Rattus norvegicus	77-81
12359718-4	2002	Surprisingly however, Fuc-TIV-generated sLe(x) was resistant to proteinase K and trypsin treatment and could be removed from cells by delipidation with chloroform/methanol, whereas 80-90% of Fuc-TVII-generated sLe(x) was protease-sensitive, and most of it resistant to delipidation.	Chloroform	152-162	fucosyltransferase 4	Mus musculus	22-29
12465028-2	2002	We recently solved the three-dimensional structure of chemically synthesized, unphosphorylated, monomeric PLN (C41F) by high-resolution nuclear magnetic resonance spectroscopy in chloroform/methanol.	Chloroform	179-189	phospholamban	Homo sapiens	106-109
12776536-6	2002	AE-1 elevated 5-HT level in the striatum and the NE and DA level in the cortex, chloroform fraction (AE-2) only significantly increased DA level in cortex.	Chloroform	80-90	solute carrier family 4 (anion exchanger), member 2	Mus musculus	101-105
15562719-4	2002	The chloroform fraction markedly enhanced the lymphocytes proliferation induced by ConA or LPS.	Chloroform	4-14	toll-like receptor 4	Mus musculus	91-94
12223239-3	2002	Using the CHCl(3)/MeOH (5:1 v/v) spreading solvent, we found an average molecular area of ZL-DHP of approximately 1200 A(2).	Chloroform	10-17	dihydropyrimidinase	Homo sapiens	93-96
12510749-5	2002	CL intensities of CH2Cl2, CHCl3, and CCl4 at the same concentration increased in the order CH2Cl2 < CHCl3 < CCl4.	Chloroform	26-31	C-C motif chemokine ligand 4	Homo sapiens	114-118
12510749-5	2002	CL intensities of CH2Cl2, CHCl3, and CCl4 at the same concentration increased in the order CH2Cl2 < CHCl3 < CCl4.	Chloroform	103-108	C-C motif chemokine ligand 4	Homo sapiens	37-41
12510749-5	2002	CL intensities of CH2Cl2, CHCl3, and CCl4 at the same concentration increased in the order CH2Cl2 < CHCl3 < CCl4.	Chloroform	103-108	C-C motif chemokine ligand 4	Homo sapiens	114-118
12619290-1	2002	The transfer behavior of Pb(II) through the bulk liquid membrane system of PC-88A-CHCl3 was studied.	Chloroform	82-87	submaxillary gland androgen regulated protein 3B	Homo sapiens	25-31
12220494-2	2002	GC/MS and NMR analysis of chloroform/methanol extracts from purified HNF4alpha and HNF4gamma LBDs identified mixtures of saturated and cis-monounsaturated C14-18 fatty acids.	Chloroform	26-36	hepatocyte nuclear factor 4 gamma	Homo sapiens	83-92
12162870-2	2002	The general population in Canada is exposed to chloroform principally through inhalation of indoor air, particularly during showering, and through ingestion of tap water.	Chloroform	47-57	nuclear RNA export factor 1	Rattus norvegicus	160-163
12224751-5	2002	Results of the analysis suggest that toxicological scientists want to close the door on the "chloroform issue" due to increasing evidence that chloroform is safe at low doses, because epidemiological scientists can no longer move forward the cancer science until significant improvements can be made in assessing human exposures, and because the scientific foci of research on DBP have shifted accordingly.	Chloroform	93-103	D-box binding PAR bZIP transcription factor	Homo sapiens	377-380
12084067-7	2002	Employing NMR spectroscopy we found this part of Vpr to be almost completely alpha helical in the presence of micelles, as well as in trifluoroethanol containing and methanol/chloroform solvent.	Chloroform	175-185	Vpr	Human immunodeficiency virus 1	49-52
11893390-1	2002	In our earlier communication on urea denaturation of bovine serum albumin (BSA), we showed significant unfolding of domain III along with domain I prior to intermediate formation around 4.6-5.2 M urea based on the binding results of domain specific ligands:chloroform, bilirubin and diazepam for domains I, II and III, respectively.	Chloroform	257-267	albumin	Homo sapiens	60-73
11993865-4	2002	Cobb County, GA, tap water exhibited high THM concentrations composed primarily of chloroform.	Chloroform	83-93	nuclear RNA export factor 1	Homo sapiens	17-20
12005512-2	2002	The solubilized cytochrome c was stable and showed peroxidase activity in chloroform.	Chloroform	74-84	cytochrome c, somatic	Homo sapiens	16-28
11960421-1	2002	The structure of one of the three previously separated isomers of {Er2@C82} has been determined through a single-crystal X-ray structure determination of the noncovalent adduct, {Er2@C82 Isomer I}.{CoII(OEP)}.1.4(C6H6).0.3(CHCl3).	Chloroform	223-228	complement C8 beta chain	Homo sapiens	71-74
11960421-1	2002	The structure of one of the three previously separated isomers of {Er2@C82} has been determined through a single-crystal X-ray structure determination of the noncovalent adduct, {Er2@C82 Isomer I}.{CoII(OEP)}.1.4(C6H6).0.3(CHCl3).	Chloroform	223-228	complement C8 beta chain	Homo sapiens	183-186
11931710-3	2002	PI3 -K was assayed by incubating recombinant PI3-K p110beta with phosphatidylinositol-4,5-bisphosphate and [gamma-32P]ATP; the [32 P]-radiolabeled lipids were extracted with chloroform and methanol, assessed by thin layer chromatography and visualized by autoradiography.	Chloroform	174-184	peptidase inhibitor 3	Homo sapiens	0-3
11931710-3	2002	PI3 -K was assayed by incubating recombinant PI3-K p110beta with phosphatidylinositol-4,5-bisphosphate and [gamma-32P]ATP; the [32 P]-radiolabeled lipids were extracted with chloroform and methanol, assessed by thin layer chromatography and visualized by autoradiography.	Chloroform	174-184	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	51-59
11855835-6	2002	Then, total RNA was extracted by phenol/chloroform from 1 ml urine of healthy volunteers, and S100A5 was amplified by RT-PCR from all samples (n = 12), indicating that the transcript of S100A5 is detectable even in the cells released into urine.	Chloroform	40-50	S100 calcium binding protein A5	Homo sapiens	186-192
11839208-6	2002	Interaction of [3H] pBR 322 DNA with chlorpromazine, perphenazine, and chloroquine was studied using these compounds as their free bases dissolved in chloroform, followed by their impregnation onto Whatman No.	Chloroform	150-160	translocator protein	Homo sapiens	20-23
11911460-4	2002	From the highest inhibitory fraction, the chloroform fraction (75%) on AChE, the single compound, was obtained by the Sep-Pak Cartridge (C18: reverse phase column).	Chloroform	42-52	acetylcholinesterase	Rattus norvegicus	71-75
12659121-1	2002	N-Bromosuccinimide (NBS) was found to afford photochemical bromination of N-substituted 3-methyl-2-pyrazolin-5-one in chloroform solution.	Chloroform	118-128	nibrin	Homo sapiens	20-23
11520031-1	2001	Pulmonary surfactant protein SP-C has been isolated from porcine lungs and treated with dansyl isothiocyanate in chloroform:methanol 2:1 (v/v) solutions,under conditions optimized to introduce a single dansyl group covalently attached to the N-terminalamine group of the protein without loss of its native thioesther-linked palmitic chains.	Chloroform	113-123	surfactant protein C	Homo sapiens	29-33
11834892-2	2002	Tryptophan fluorescence quenching has been used previously to show that halothane and chloroform bind saturably to serum albumin, and a similar approach is used here to demonstrate that TCE also binds to albumin.	Chloroform	86-96	albumin	Homo sapiens	115-128
15348357-7	2001	Metalloproteinase (MMP-2) activity was detected in all the samples analyzed but a higher expression of MMP-9 was detected in those implants treated with chloroform/methanol and ethanol.	Chloroform	153-163	matrix metallopeptidase 2	Rattus norvegicus	19-24
15348357-7	2001	Metalloproteinase (MMP-2) activity was detected in all the samples analyzed but a higher expression of MMP-9 was detected in those implants treated with chloroform/methanol and ethanol.	Chloroform	153-163	matrix metallopeptidase 9	Rattus norvegicus	103-108
11783791-8	2001	A partial transfer of the [CoX4]2- species from a "water pool" into the CHCl3 phase by the addition of the metal salts may be suspected.	Chloroform	72-77	cytochrome c oxidase subunit 4I2	Homo sapiens	27-33
11377088-2	2001	These methods are based on the formation of chloroform soluble complexes between CTZH with bromocresol purple (BCP) or bromophenol blue (BPB) in Walpole buffer of pH 2.64 with an absorption maximum at 409 nm and at 414 nm for BCP and BPB, respectively.	Chloroform	44-54	opsin 1, short wave sensitive	Homo sapiens	111-114
11377088-2	2001	These methods are based on the formation of chloroform soluble complexes between CTZH with bromocresol purple (BCP) or bromophenol blue (BPB) in Walpole buffer of pH 2.64 with an absorption maximum at 409 nm and at 414 nm for BCP and BPB, respectively.	Chloroform	44-54	opsin 1, short wave sensitive	Homo sapiens	226-237
11340656-2	2001	Experimental studies indicate that while the helical fold of SP-C is thermodynamically stable in phospholipid micelles, it is metastable in a mixed organic solvent of CHCl3/CH3OH/0.1 M HCl at 32:64:5 (v/v/v), in which it undergoes an irreversible transformation to an insoluble aggregate that contains beta-sheet.	Chloroform	167-172	surfactant protein C	Homo sapiens	61-65
11373082-1	2001	We have developed an enzyme-linked immunosorbent assay (ELISA) that uses polyclonal or monoclonal anti-surfactant protein SP-B antibodies to quantitate purified SP-B in chloroform/methanol and in chloroform/methanol extracts of whole pulmonary surfactant at nanogram levels.	Chloroform	169-179	surfactant protein B	Homo sapiens	161-165
11137464-4	2000	Two different fractions (ethanol or chloroform soluble extracts) of CSE with their chemical types identified showed a time- and dose-dependent increase on IL-8 secretion from ECV304 cell line.	Chloroform	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
11323233-10	2001	This carbonyl complex was used for the direct labelling of surfactant protein B (SP-B) under non-reductive conditions by direct incubation with SP-B at elevated temperature followed by extraction into CHCl(3)/MeOH.	Chloroform	201-208	surfactant protein B	Homo sapiens	59-79
11323233-10	2001	This carbonyl complex was used for the direct labelling of surfactant protein B (SP-B) under non-reductive conditions by direct incubation with SP-B at elevated temperature followed by extraction into CHCl(3)/MeOH.	Chloroform	201-208	surfactant protein B	Homo sapiens	81-85
11137464-6	2000	Protein tyrosine kinase (PTK) inhibitor genistein and protein kinase A (PKA) inhibitor H8 at respective concentrations significantly reduced chloroform and ethanol soluble extract-induced IL-8 expression by about 34 and 35% respectively at 8 h after incubation.	Chloroform	141-151	EPH receptor A8	Homo sapiens	0-23
11196994-3	2000	Complex 3 undergoes extensive rearrangement in CHCl3 at room temperature by transfer of a PPh3 ligand from Pd to W, eliminating [W(CO)5(PPh3)] (7), while the PPh2CS2Me ligand transfers from W to Pd to give [[(Ph3P)Pd[mu-eta 1,eta 2-(CS2Me)PPh2]]2] (6).	Chloroform	47-52	protein phosphatase 4 catalytic subunit	Homo sapiens	90-94
11137464-6	2000	Protein tyrosine kinase (PTK) inhibitor genistein and protein kinase A (PKA) inhibitor H8 at respective concentrations significantly reduced chloroform and ethanol soluble extract-induced IL-8 expression by about 34 and 35% respectively at 8 h after incubation.	Chloroform	141-151	EPH receptor A8	Homo sapiens	25-28
11064134-2	2000	FTIR-ATR (attenuated total reflectance) spectroscopy was used to monitor the polyanhydride/anhydride reaction rates in dichloromethane, dichloroethane, chloroform, and 1,4-dioxane solutions at room temperature.	Chloroform	152-162	ATR serine/threonine kinase	Homo sapiens	5-8
11140442-4	2000	Chloroform was generally, but not always, the most predominant DBP.	Chloroform	0-10	D-box binding PAR bZIP transcription factor	Homo sapiens	63-66
10880510-12	2000	As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.	Chloroform	70-80	potassium two pore domain channel subfamily K member 2	Homo sapiens	8-13
10880510-12	2000	As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.	Chloroform	70-80	potassium two pore domain channel subfamily K member 10	Homo sapiens	15-20
10993252-0	2000	Detecting hydrogen bonding by NMR relaxation of the acceptor nuclei The formation of hydrogen bonds (HB) between phenol or N-methyltrifluoroacetamide and several acceptors (pyridine, carbonyl compounds, nitriles, amides) in CCl4 or CHCl3 been investigated through the analysis of NMR relaxation times (T1) of the heteronuclei (14N and 17O) directly involved in the HB interaction.	Chloroform	232-237	C-C motif chemokine ligand 4	Homo sapiens	224-228
10901162-4	2000	The chloroform solubles, which were high in inhibitory effect of acetylcholinesterase, were repeatedly subjected to open column chromatography on silica gel.	Chloroform	4-14	acetylcholinesterase	Rattus norvegicus	65-85
18967996-2	2000	The solvent extraction of Pb(II) and of Cu(II) from buffered aqueous solutions of varying pH into chloroform by ligands 1-5 is examined in relation to the molecular structure of the dicarboxylic acid extractant.	Chloroform	98-108	submaxillary gland androgen regulated protein 3B	Homo sapiens	26-46
11196994-3	2000	Complex 3 undergoes extensive rearrangement in CHCl3 at room temperature by transfer of a PPh3 ligand from Pd to W, eliminating [W(CO)5(PPh3)] (7), while the PPh2CS2Me ligand transfers from W to Pd to give [[(Ph3P)Pd[mu-eta 1,eta 2-(CS2Me)PPh2]]2] (6).	Chloroform	47-52	protein phosphatase 4 catalytic subunit	Homo sapiens	136-140
11196994-3	2000	Complex 3 undergoes extensive rearrangement in CHCl3 at room temperature by transfer of a PPh3 ligand from Pd to W, eliminating [W(CO)5(PPh3)] (7), while the PPh2CS2Me ligand transfers from W to Pd to give [[(Ph3P)Pd[mu-eta 1,eta 2-(CS2Me)PPh2]]2] (6).	Chloroform	47-52	secreted phosphoprotein 1	Homo sapiens	220-225
11196994-3	2000	Complex 3 undergoes extensive rearrangement in CHCl3 at room temperature by transfer of a PPh3 ligand from Pd to W, eliminating [W(CO)5(PPh3)] (7), while the PPh2CS2Me ligand transfers from W to Pd to give [[(Ph3P)Pd[mu-eta 1,eta 2-(CS2Me)PPh2]]2] (6).	Chloroform	47-52	DNA polymerase iota	Homo sapiens	226-231
10845788-2	2000	Raman spectroscopy is used to characterize the behavior of the C18 bonded ligands equilibrated at temperatures from 45 to 2 degrees C in neat, single-component, mobile phase solvents including: water, acetonitrile, methanol, and chloroform.	Chloroform	229-239	Bardet-Biedl syndrome 9	Homo sapiens	63-66
10722078-4	2000	The chromatographic analysis of the fat-soluble vitamins was carried out after their sequential elution with methanol and chloroform from C18 sorbent, on the above column.	Chloroform	122-132	Bardet-Biedl syndrome 9	Homo sapiens	138-141
10845776-5	2000	[3H]Palmitoylation of synaptobrevin 2 was resistant to chloroform/methanol extraction, but sensitive to reducing agents indicating a covalent fatty acid bond to cysteine residues.	Chloroform	55-65	vesicle-associated membrane protein 2	Rattus norvegicus	22-37
10757281-11	2000	Chloroform, having a concentration lower than 1 ppb, was detected in tap water.	Chloroform	0-10	nuclear RNA export factor 1	Homo sapiens	69-72
10738214-4	2000	Phenol-chloroform-extracted DNA specimens were employed for the detection of HBV infection and p53 gene mutations.	Chloroform	7-17	tumor protein p53	Homo sapiens	95-98
18967721-5	1999	A sequential extraction of a water sample with n-hexane and ethyl acetate is used to separate NS and other interferents as well as dichloromethane and chloroform for the separation of PEG into LC- and SC-fractions.	Chloroform	151-161	progestagen associated endometrial protein	Homo sapiens	184-187
12541595-6	2000	So it"s quite more evident on NH2 column than on C18 column that the delaying effect of the solvent, with methanol, acetone and chloroform in decreasing sequence, encourages the elution of the analytes during continuous injections.	Chloroform	128-138	Bardet-Biedl syndrome 9	Homo sapiens	49-52
11931114-3	2000	Oxidative deprotonation of [Ru(II)(Por)(NH2-p-C6H4Cl)2] in chloroform by air generated bis(arylamido)ruthenium(IV) porphyrins, [RuIV(Por)(NH-p-C6H4Cl)2] (Por=TTP.	Chloroform	59-69	cytochrome p450 oxidoreductase	Homo sapiens	35-38
11931114-3	2000	Oxidative deprotonation of [Ru(II)(Por)(NH2-p-C6H4Cl)2] in chloroform by air generated bis(arylamido)ruthenium(IV) porphyrins, [RuIV(Por)(NH-p-C6H4Cl)2] (Por=TTP.	Chloroform	59-69	cytochrome p450 oxidoreductase	Homo sapiens	133-136
11931114-3	2000	Oxidative deprotonation of [Ru(II)(Por)(NH2-p-C6H4Cl)2] in chloroform by air generated bis(arylamido)ruthenium(IV) porphyrins, [RuIV(Por)(NH-p-C6H4Cl)2] (Por=TTP.	Chloroform	59-69	cytochrome p450 oxidoreductase	Homo sapiens	133-136
11307469-6	2000	In comparison with other classes of material, Ketac Endo was the least soluble in chloroform and halothane (P < 0.01), with less than 1% weight loss after 10 min exposure to either solvent.	Chloroform	82-92	mannosidase endo-alpha	Homo sapiens	52-56
10607459-1	1999	Chloroform in tap water has been a significant problem because it may be a carcinogenic substituent.	Chloroform	0-10	nuclear RNA export factor 1	Homo sapiens	14-17
10527910-0	1999	Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney, and nose of male mice.	Chloroform	14-24	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	28-47
10527910-12	1999	Induced pathological changes and regenerative cell proliferation were absent in these target sites in Cyp2e1-/- mice exposed to 90 ppm chloroform.	Chloroform	135-145	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	102-108
18967721-9	1999	An initial separation of PEG from these samples by extraction with chloroform is carried out.	Chloroform	67-77	progestagen associated endometrial protein	Homo sapiens	25-28
10478140-3	1999	Previously, in a published case of chloroform poisoning, we serially assayed serum biomarkers of hepatocellular necrosis (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase) and markers of hepatocellular regeneration (alpha-fetoprotein, retinol-binding protein, gamma-glutamyl transferase, and des-gamma-carboxyprothrombin).	Chloroform	35-45	alpha fetoprotein	Homo sapiens	265-282
10444367-3	1999	We report here a method for quantitative measurement of iNOS mRNA levels with rtPCR directly from cells lysed with a single step phenol/chloroform/ether extraction.	Chloroform	136-146	nitric oxide synthase 2, inducible	Mus musculus	56-60
10477824-10	1999	However, SP-B can be recovered from the walls of polypropylene and Teflon tubes by washing with chloroform:methanol.	Chloroform	96-106	surfactant protein B	Canis lupus familiaris	9-13
10321245-4	1999	Chloroform, diethyl ether, halothane and isoflurane activated TREK-1, whereas only halothane and isoflurane activated TASK.	Chloroform	0-10	potassium two pore domain channel subfamily K member 2	Homo sapiens	62-68
10367377-8	1999	The ion pair formed is extracted in chloroform at pH 4, and its absorbance is measured at 562 nm.	Chloroform	36-46	prolyl 4-hydroxylase, transmembrane	Homo sapiens	50-54
11783303-1	1999	OBJECTIVE: To explore the effect of TCM on plasma beta-endorphin (beta-EP) and placental endocrine function in patients of threatened abortions (TA).	Chloroform	36-39	proopiomelanocortin	Homo sapiens	50-64
10076065-2	1999	SOD-1 samples were prepared from erythrocytes by removing hemoglobin using hemoglobind gel followed by ethanol and chloroform extraction.	Chloroform	115-125	superoxide dismutase 1	Homo sapiens	0-5
10229719-3	1999	In 1976, chloroform, a trihalomethane (THM) and a principal DBP, was shown to be carcinogenic in rodents.	Chloroform	9-19	D-box binding PAR bZIP transcription factor	Homo sapiens	60-63
11783303-1	1999	OBJECTIVE: To explore the effect of TCM on plasma beta-endorphin (beta-EP) and placental endocrine function in patients of threatened abortions (TA).	Chloroform	36-39	proopiomelanocortin	Homo sapiens	66-73
9915333-2	1999	In the case of bovine serum albumin, the sites of halothane and chloroform binding have been identified as being located in the IB and IIA subdomains.	Chloroform	64-74	albumin	Homo sapiens	22-35
9874700-6	1999	CsA gave many new peaks in the 1H NMR spectrum when the solvent was changed from chloroform to methanol/water, suggesting conformational diversity of CsA in polar solvents.	Chloroform	81-91	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	0-3
9914470-1	1999	The anesthetics benzyl alcohol and the nonaromatic chloroform and diethyl ether, abolish P-glycoprotein (Pgp) ATPase activity in a mode that does not fit classical competitive, noncompetitive, or uncompetitive inhibition.	Chloroform	51-61	ATP binding cassette subfamily B member 1	Homo sapiens	89-103
9914470-1	1999	The anesthetics benzyl alcohol and the nonaromatic chloroform and diethyl ether, abolish P-glycoprotein (Pgp) ATPase activity in a mode that does not fit classical competitive, noncompetitive, or uncompetitive inhibition.	Chloroform	51-61	ATP binding cassette subfamily B member 1	Homo sapiens	105-108
9914470-1	1999	The anesthetics benzyl alcohol and the nonaromatic chloroform and diethyl ether, abolish P-glycoprotein (Pgp) ATPase activity in a mode that does not fit classical competitive, noncompetitive, or uncompetitive inhibition.	Chloroform	51-61	dynein axonemal heavy chain 8	Homo sapiens	110-116
9874700-6	1999	CsA gave many new peaks in the 1H NMR spectrum when the solvent was changed from chloroform to methanol/water, suggesting conformational diversity of CsA in polar solvents.	Chloroform	81-91	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	150-153
9512070-8	1998	Such paradoxical effects were at least partially explained when different extracts of the leaves were used; a weakly basic chloroform fraction caused an increase in MAO A inhibitory activity, whereas butanol extracts brought about a decrease.	Chloroform	123-133	monoamine oxidase A	Rattus norvegicus	165-170
9887287-8	1999	Revised liquid state 1H and 13C (29Si) CSA data are presented for chloroform and TPSi.	Chloroform	66-76	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	39-42
11672368-1	1998	In chloroform solution, the syn/anti rotamer ratios for N-(2-pyridyl)carbamates, 3, and N-phenylcarbamates, 4, are close to 0.05.	Chloroform	3-13	synemin	Homo sapiens	28-31
9747604-5	1998	Both CHCl3 and BDCM induced dose-dependent hepatotoxicity; serum alanine aminotransferase, aspartate aminotransferase, and sorbitol dehydrogenase were elevated significantly over control at 1.5, 1.0, and 0.5 mmol/kg.	Chloroform	5-10	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	91-117
9718740-12	1998	Although ingestion is commonly considered to be the primary source of exposure to chloroform from tap water, inhalation and skin absorption exposure concentrations were found to be even higher.	Chloroform	82-92	nuclear RNA export factor 1	Homo sapiens	98-101
9865947-2	1998	The alpha-helical form of SP-C observed in freshly prepared solutions in a mixed solvent of CHCl3/CH3OH/0.1 M HCl 32:64:5 (v/v/v) at 10 degrees C undergoes within a few days an irreversible transformation to an insoluble aggregate that contains beta-sheet secondary structure.	Chloroform	92-97	surfactant protein C	Homo sapiens	26-30
9849623-2	1998	The rate of consumption of H2O2 in chloroform catalyzed by the lyophilized catalase with 3 was enhanced more than 10 times that by catalase without 3.	Chloroform	35-45	catalase	Bos taurus	75-83
9849623-2	1998	The rate of consumption of H2O2 in chloroform catalyzed by the lyophilized catalase with 3 was enhanced more than 10 times that by catalase without 3.	Chloroform	35-45	catalase	Bos taurus	131-139
9849623-3	1998	The dispersibility and solubility of lyophilized catalase with 3 in chloroform were improved in comparison with catalase itself.	Chloroform	68-78	catalase	Bos taurus	49-57
18967183-7	1998	Preceded by decomposition of organolead compounds with concentrated nitric acid, then ashing at 300 degrees C and a solvent extraction of Pb(II) benzoylacetonate in chloroform, the suitability of the proposed method for the determination of lead in free-lead gasoline and gas oil was demonstrated as a typical example of application.	Chloroform	165-175	submaxillary gland androgen regulated protein 3B	Homo sapiens	138-144
9518582-2	1998	Pulmonary surfactant proteins SP-B and SP-C were isolated from the extracts using gel-exclusion chromatography on LH-60 with chloroform:methanol acidified with hydrochloric acid.	Chloroform	125-135	surfactant protein C	Homo sapiens	39-43
9518582-3	1998	Monolayers of pure SP-B or SP-C isolated from butanol lipid extracts spread at the air-water interface showed larger molecular areas than those determined in films of SP-B or SP-C isolated from chloroform surfactant extracts.	Chloroform	194-204	surfactant protein C	Homo sapiens	175-179
9518582-4	1998	Aqueous dispersions of dipalmitoylphosphatidylcholine (DPPC) supplemented with 2.5 and 5.0 wt% of SP-B or SP-C obtained from butanol extracts adsorbed faster to the air-water interface than their counterparts reconstituted with proteins isolated from chloroform extracts.	Chloroform	251-261	surfactant protein B	Homo sapiens	98-102
9518582-4	1998	Aqueous dispersions of dipalmitoylphosphatidylcholine (DPPC) supplemented with 2.5 and 5.0 wt% of SP-B or SP-C obtained from butanol extracts adsorbed faster to the air-water interface than their counterparts reconstituted with proteins isolated from chloroform extracts.	Chloroform	251-261	surfactant protein C	Homo sapiens	106-110
9814691-6	1998	Ligands on LDL for beta2-GPI seemed to be intermediate oxidative derivatives which were extractable into the chloroform phase by Bligh and Dyer"s extraction, but not MDA.	Chloroform	109-119	apolipoprotein H	Homo sapiens	19-28
9531722-3	1998	Other DBP"s which may be responsible for eye irritation include halogenated carboxyl compounds (HCC"s) which act as precursors during the formation of chloroform.	Chloroform	151-161	vitamin D-binding protein	Oryctolagus cuniculus	6-9
9585263-0	1998	Long-term mutagenicity studies with chloroform and dimethylnitrosamine in female lacI transgenic B6C3F1 mice.	Chloroform	36-46	tissue factor pathway inhibitor	Mus musculus	81-85
9585263-3	1998	The purpose of the present study was to evaluate the potential mutagenic activity of chloroform in the B6C3F1 lacI transgenic mouse liver mutagenesis assay including mutagenic events that might occur secondary to cytolethality.	Chloroform	85-95	tissue factor pathway inhibitor	Mus musculus	110-114
9348725-11	1997	Liver weight and liver content of triglyceride and MDA significantly increased at 30 mg/kg of CCl4, while significant increase in GPT activity was observed at 300 mg/kg of CCl4 and CHCl3.	Chloroform	181-186	glutamic--pyruvic transaminase	Rattus norvegicus	130-133
9497799-4	1997	In this work, proteinase K-phenol-chloroform-treated sections of frozen cervical biopsies were split in two.	Chloroform	34-44	endogenous retrovirus group K member 25	Homo sapiens	14-24
9341907-2	1997	PC and 1,8-octanediol were conjugated by transesterification reaction of Streptomyces phospholipase D (PLD) under a water-chloroform biphasic system to afford phosphatidyloctanol, which was condensed with a protected 2-chloro-2-deoxyneuraminic acid derivative by using silver trifluoromethanesulfonate as an activator in chloroform and converted, after deprotection, to SPL.	Chloroform	122-132	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	86-101
9341907-2	1997	PC and 1,8-octanediol were conjugated by transesterification reaction of Streptomyces phospholipase D (PLD) under a water-chloroform biphasic system to afford phosphatidyloctanol, which was condensed with a protected 2-chloro-2-deoxyneuraminic acid derivative by using silver trifluoromethanesulfonate as an activator in chloroform and converted, after deprotection, to SPL.	Chloroform	122-132	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	103-106
9341907-2	1997	PC and 1,8-octanediol were conjugated by transesterification reaction of Streptomyces phospholipase D (PLD) under a water-chloroform biphasic system to afford phosphatidyloctanol, which was condensed with a protected 2-chloro-2-deoxyneuraminic acid derivative by using silver trifluoromethanesulfonate as an activator in chloroform and converted, after deprotection, to SPL.	Chloroform	321-331	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	86-101
9341907-2	1997	PC and 1,8-octanediol were conjugated by transesterification reaction of Streptomyces phospholipase D (PLD) under a water-chloroform biphasic system to afford phosphatidyloctanol, which was condensed with a protected 2-chloro-2-deoxyneuraminic acid derivative by using silver trifluoromethanesulfonate as an activator in chloroform and converted, after deprotection, to SPL.	Chloroform	321-331	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	103-106
9201608-3	1997	The results indicated that the CHCl3 fraction and EtOAc fractions exhibited the greatest hepatoprotective effects on CCl4-induced liver injuries, the CHCl3 fraction and n-hexane fraction are most potent against D-GalN-induced intoxication, and the CHCl3 fraction represented the most liver-protective effect on APAP-induced hepatotoxicity.	Chloroform	31-36	C-C motif chemokine ligand 4	Rattus norvegicus	117-121
9218421-4	1997	Chloroform quenches the steady-state tryptophan fluorescence of bovine serum albumin (BSA) in a concentration-dependent, saturable manner with a Kd = 2.7 +/- 0.2 mM.	Chloroform	0-10	albumin	Homo sapiens	71-84
9299539-2	1997	The procedure employs homogenization of central nervous system (CNS) tissue in chloroform, which specifically extracts MBP.	Chloroform	79-89	myelin basic protein	Mus musculus	119-122
9417990-5	1997	Separation was achieved by preferential solubilization of non-glycosylated CHIP28 in CHCl3/MeOH/H2O mixtures.	Chloroform	85-90	aquaporin 1 (Colton blood group)	Homo sapiens	75-81
9184656-3	1997	Acid guanidinium isothiocyanate phenol-chloroform extraction of RNA appeared less efficient for IL-1 beta mRNA detection by RT-PCR than proteinase K digestion followed by phenol-chloroform extraction.	Chloroform	39-49	interleukin 1 beta	Homo sapiens	96-105
9201608-3	1997	The results indicated that the CHCl3 fraction and EtOAc fractions exhibited the greatest hepatoprotective effects on CCl4-induced liver injuries, the CHCl3 fraction and n-hexane fraction are most potent against D-GalN-induced intoxication, and the CHCl3 fraction represented the most liver-protective effect on APAP-induced hepatotoxicity.	Chloroform	150-155	C-C motif chemokine ligand 4	Rattus norvegicus	117-121
9201608-3	1997	The results indicated that the CHCl3 fraction and EtOAc fractions exhibited the greatest hepatoprotective effects on CCl4-induced liver injuries, the CHCl3 fraction and n-hexane fraction are most potent against D-GalN-induced intoxication, and the CHCl3 fraction represented the most liver-protective effect on APAP-induced hepatotoxicity.	Chloroform	150-155	C-C motif chemokine ligand 4	Rattus norvegicus	117-121
9095367-6	1997	A clear redox response of the PEO-modified myoglobin was observed after methanol treatment of these layers cast from chloroform or a benzene solution.	Chloroform	117-127	myoglobin	Equus caballus	43-52
9095367-7	1997	This suggests that the conformational change of the adsorbed PEO-modified myoglobin layer on the ITO electrode cast from chloroform or a benzene solution was not irreversible.	Chloroform	121-131	myoglobin	Equus caballus	74-83
9068631-8	1997	When expressed from a tac promoter, the orf6 gene product caused immediate cell death without lysis, while cultures expressing the orf7 gene product grew at normal rates but lysed immediately after the addition of chloroform.	Chloroform	214-224	hypothetical protein	Escherichia coli	131-135
9155741-7	1997	However, when the medium was subjected to organic extraction by the Bligh-Dyer (methanol/chloroform) method and the resulting extract added to equivalent media, embryo-derived PAF was readily degraded by PAF:AH.	Chloroform	89-99	patchy fur	Mus musculus	176-179
9155741-7	1997	However, when the medium was subjected to organic extraction by the Bligh-Dyer (methanol/chloroform) method and the resulting extract added to equivalent media, embryo-derived PAF was readily degraded by PAF:AH.	Chloroform	89-99	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	Mus musculus	204-210
9893740-8	1997	These results also suggest that the destruction of cytochrome P450 during anaerobic dechlorination of carbon tetrachloride in microsomes was caused by direct attack by the trichloromethyl radical, rather than by carbon tetrachloride-induced lipid peroxidation.	Chloroform	172-195	cytochrome P450 3A14	Cavia porcellus	51-66
9332701-3	1997	The CYP content and the activity of CYP2E1 markedly decreased in the CCl4-treated rats 3 h after treatment compared to much lower decreases in the CHCl3-treated rats.	Chloroform	147-152	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	4-7
9332701-7	1997	In both groups of rats, ALT and AST activities reached a maximum at 24 h, and gradually decreased, remaining at abnormal levels at 72 h. Hepatic cells in the CCl4-treated rats were found to be necrotic as early as 3 h post-treatment, whereas few or no morphological changes appeared in the liver of CHCl3-treated rats.	Chloroform	299-304	C-C motif chemokine ligand 4	Rattus norvegicus	158-162
9007029-14	1997	The dose- and route-dependent differences in the effect of enzyme induction on the metabolism and toxicity between CHCl3 and CCl4 can be explained by a supposition that the hepatic blood flow rate-limits the metabolism of a low dose of CHCl3 (perfusion-limited metabolism), whereas the metabolic capacity of the liver limits the metabolism of CCl4 (capacity-limited metabolism) irrespective of dose.	Chloroform	115-120	C-C motif chemokine ligand 4	Rattus norvegicus	343-347
9007029-14	1997	The dose- and route-dependent differences in the effect of enzyme induction on the metabolism and toxicity between CHCl3 and CCl4 can be explained by a supposition that the hepatic blood flow rate-limits the metabolism of a low dose of CHCl3 (perfusion-limited metabolism), whereas the metabolic capacity of the liver limits the metabolism of CCl4 (capacity-limited metabolism) irrespective of dose.	Chloroform	236-241	C-C motif chemokine ligand 4	Rattus norvegicus	125-129
9007029-14	1997	The dose- and route-dependent differences in the effect of enzyme induction on the metabolism and toxicity between CHCl3 and CCl4 can be explained by a supposition that the hepatic blood flow rate-limits the metabolism of a low dose of CHCl3 (perfusion-limited metabolism), whereas the metabolic capacity of the liver limits the metabolism of CCl4 (capacity-limited metabolism) irrespective of dose.	Chloroform	236-241	C-C motif chemokine ligand 4	Rattus norvegicus	343-347
8975762-9	1996	The results support the hypothesis that DCA increases CHCl3 metabolism, and therefore hepatotoxicity, by inducing CYP2E1.	Chloroform	54-59	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	114-120
9490511-4	1997	According to features of the inotropic action the studied agents were divided into two groups: Cth values of the former group were dependent on stimulation frequency (V, methanol, ethanol, isopropanol, chloral hydrate and acetone); Cth values of agents of the latter group were independent on stimulation frequency (n-butanol, n-pentanol, n-hexanol, and chloroform).	Chloroform	354-364	V-set and immunoglobulin domain containing 2	Homo sapiens	95-98
9148421-4	1996	The method studied is a nested RT-PCR that amplifies the CK19 expression from the sample RNA extracted following the method of phenol-chloroform.	Chloroform	134-144	keratin 19	Homo sapiens	57-61
8660611-4	1996	GSL containing silica gel was scraped off and extracted with chloroform:methanol:water (30:60:8, by vol).	Chloroform	61-71	cathepsin A	Homo sapiens	0-3
8660611-6	1996	Finally, a stepwise chloroform:methanol gradient chromatography on a small silica gel K60 column was employed to remove non-GSL impurities.	Chloroform	20-30	cathepsin A	Homo sapiens	124-127
8822049-5	1996	The activity of TNF alpha induction was mainly found in the methanol-phase, but not in the chloroform-phase, where lipid and glycolipid of the microorganisms were generally thought to be accumulated.	Chloroform	91-101	tumor necrosis factor	Homo sapiens	16-25
8665616-2	1996	Results from anaerobic in vitro experiments with hepatic microsomes isolated from male F-344 rats indicate that chlorofom (CHCl3) formation from CCl4 is nonlinear with dose.	Chloroform	123-128	C-C motif chemokine ligand 4	Rattus norvegicus	145-149
8665616-6	1996	Dose-response curves, based on total amount of CCl4 added to the microsomes, revealed a nonlinear, biphasic appearance of CHCl3, with fasting slightly increasing CHCl3 production in microsomes prepared from fasted rats.	Chloroform	122-127	C-C motif chemokine ligand 4	Rattus norvegicus	47-51
8665616-13	1996	In conclusion, a pharmacokinetic model has been developed for anaerobic in vitro metabolism of CCl4 to CHCl3 that estimates metabolic rates based on CHCl3 formation and actual CCl4 concentration in the microsomal suspension.	Chloroform	103-108	C-C motif chemokine ligand 4	Rattus norvegicus	95-99
8665616-13	1996	In conclusion, a pharmacokinetic model has been developed for anaerobic in vitro metabolism of CCl4 to CHCl3 that estimates metabolic rates based on CHCl3 formation and actual CCl4 concentration in the microsomal suspension.	Chloroform	103-108	C-C motif chemokine ligand 4	Rattus norvegicus	176-180
8665616-13	1996	In conclusion, a pharmacokinetic model has been developed for anaerobic in vitro metabolism of CCl4 to CHCl3 that estimates metabolic rates based on CHCl3 formation and actual CCl4 concentration in the microsomal suspension.	Chloroform	149-154	C-C motif chemokine ligand 4	Rattus norvegicus	95-99
8658503-1	1996	The purpose of this study was to find out how liver injury caused by two well-known hepatotoxins, chloroform and thioacetamide, alters the expression of hepatic xenobiotic metabolizing cytochrome P450 (CYP) enzymes of DBA/2N mice.	Chloroform	98-108	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	185-200
8658503-1	1996	The purpose of this study was to find out how liver injury caused by two well-known hepatotoxins, chloroform and thioacetamide, alters the expression of hepatic xenobiotic metabolizing cytochrome P450 (CYP) enzymes of DBA/2N mice.	Chloroform	98-108	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	202-205
9176742-3	1996	At 0.1 mM CHCl3 concentration, the only major contribution to its oxidative biotransformation in liver microsomes from untreated rats was due to CYP2E1, as shown by metabolic inhibition due to 4-methylpyrazole or by anti-CYP2E1 antibodies.	Chloroform	10-15	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	145-151
9176742-3	1996	At 0.1 mM CHCl3 concentration, the only major contribution to its oxidative biotransformation in liver microsomes from untreated rats was due to CYP2E1, as shown by metabolic inhibition due to 4-methylpyrazole or by anti-CYP2E1 antibodies.	Chloroform	10-15	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	221-227
9176742-5	1996	At 5 mM chloroform, in control rat liver microsomes, CYP2B1/2 was the major participant responsible for chloroform activation, while CYP2E1 and CYP2C11 were also significantly involved.	Chloroform	8-18	cytochrome P450, family 2, subfamily b, polypeptide 12	Rattus norvegicus	53-61
9176742-5	1996	At 5 mM chloroform, in control rat liver microsomes, CYP2B1/2 was the major participant responsible for chloroform activation, while CYP2E1 and CYP2C11 were also significantly involved.	Chloroform	8-18	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	133-139
9176742-5	1996	At 5 mM chloroform, in control rat liver microsomes, CYP2B1/2 was the major participant responsible for chloroform activation, while CYP2E1 and CYP2C11 were also significantly involved.	Chloroform	8-18	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	144-151
9176742-5	1996	At 5 mM chloroform, in control rat liver microsomes, CYP2B1/2 was the major participant responsible for chloroform activation, while CYP2E1 and CYP2C11 were also significantly involved.	Chloroform	104-114	cytochrome P450, family 2, subfamily b, polypeptide 12	Rattus norvegicus	53-61
8818866-5	1996	These results indicate that trichloromethyl radical, an intermediate product of carbon tetrachloride, easily combines to the haeme part of cytochrome P-450, whereas the protein part combines to isoflurane after being reduced by NADPH, which results in acceleration of carbon tetrachloride dechlorination under a lower concentration of carbon tetrachloride.	Chloroform	28-51	cytochrome P450 3A14	Cavia porcellus	139-155
8625290-0	1996	Levels of myc, fos, Ha-ras, met and hepatocyte growth factor mRNA during regenerative cell proliferation in female mouse liver and male rat kidney after a cytotoxic dose of chloroform.	Chloroform	173-183	myelocytomatosis oncogene	Mus musculus	10-13
8625290-0	1996	Levels of myc, fos, Ha-ras, met and hepatocyte growth factor mRNA during regenerative cell proliferation in female mouse liver and male rat kidney after a cytotoxic dose of chloroform.	Chloroform	173-183	hepatocyte growth factor	Mus musculus	36-60
8625290-8	1996	This pattern of gene expression is consistent with that induced by other cytotoxic carcinogens and suggest that alteration of the myc and fos genes could be involved in the regenerative cell proliferation that ultimately could play a role in chloroform-induced tumors.	Chloroform	242-252	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	130-133
8625290-8	1996	This pattern of gene expression is consistent with that induced by other cytotoxic carcinogens and suggest that alteration of the myc and fos genes could be involved in the regenerative cell proliferation that ultimately could play a role in chloroform-induced tumors.	Chloroform	242-252	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	138-141
8834861-0	1996	Ingestion, inhalation, and dermal exposures to chloroform and trichloroethene from tap water.	Chloroform	47-57	nuclear RNA export factor 1	Homo sapiens	83-86
9176742-6	1996	Consistently, at this chloroform concentration, the effect of phenobarbital (CYP2B1/2 inducer) was maximal, producing very high levels of adducts.	Chloroform	22-32	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	77-83
9176742-11	1996	Therefore, it can be argued that the CYP2B1/2-mediated induction of CHCl3 activation is the basis for the effect of PB in potentiating chloroform hepatotoxicity.	Chloroform	68-73	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	37-43
9176742-11	1996	Therefore, it can be argued that the CYP2B1/2-mediated induction of CHCl3 activation is the basis for the effect of PB in potentiating chloroform hepatotoxicity.	Chloroform	135-145	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	37-43
9176742-12	1996	Moreover, processes other than CYP2E1-mediated metabolic induction may be more relevant in the ketones potentiation of chloroform-induced acute toxicity.	Chloroform	119-129	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	31-37
7623807-9	1995	A factor(s) extracted with methanol-chloroform from transformed membranes or membranes from Sf9 cells coexpressing Ras and SrcY527F significantly enhanced the activity of Raf-1 Y340D or active Raf-1 but not that of inactive Raf-1.	Chloroform	36-46	v-raf-leukemia viral oncogene 1	Mus musculus	171-176
24414897-4	1995	When Fraction A-2 was treated with cetyltrimethylammonium hydroxide and chloroform/butanol (24:1, v/v), it behaved as a proteinbound polysaccharide, with a molecular mass estimated to be 154 kDa by gel filtration.	Chloroform	72-82	G protein-coupled receptor 162	Mus musculus	14-17
8554577-2	1995	A monomeric analogue of phospholamban PLN(C41F), in which Cys41 was replaced by a Phe, was synthesized and its conformation studied by 1H NMR spectroscopy in a 1:1 mixture of chloroform/methanol.	Chloroform	175-185	phospholamban	Homo sapiens	38-41
8590942-4	1995	The ethyl acetate is removed under vacuum, and the residue derivatized with R-(-)-1-(1-naphthyl)ethyl isocyanate (NEIC, 0.005% in chloroform) in the presence of trace quantities of carbonate buffer.	Chloroform	130-140	CD1b molecule	Homo sapiens	76-83
7503424-2	1995	Sph-1-P was first extracted from cells into the upper aqueous phase under alkaline conditions by Folch"s phase separation and then reextracted into the lower chloroform phase under acidic conditions.	Chloroform	158-168	ankyrin 1	Homo sapiens	0-5
7623807-9	1995	A factor(s) extracted with methanol-chloroform from transformed membranes or membranes from Sf9 cells coexpressing Ras and SrcY527F significantly enhanced the activity of Raf-1 Y340D or active Raf-1 but not that of inactive Raf-1.	Chloroform	36-46	v-raf-leukemia viral oncogene 1	Mus musculus	193-198
7623807-9	1995	A factor(s) extracted with methanol-chloroform from transformed membranes or membranes from Sf9 cells coexpressing Ras and SrcY527F significantly enhanced the activity of Raf-1 Y340D or active Raf-1 but not that of inactive Raf-1.	Chloroform	36-46	v-raf-leukemia viral oncogene 1	Mus musculus	193-198
8076368-0	1994	Hyperphosphorylation of p53 induced by benzene, toluene, and chloroform.	Chloroform	61-71	tumor protein p53	Homo sapiens	24-27
7645016-6	1995	These findings suggest that CYP2E1 is a low Km isoform and CYP2B1/2 a high Km isoform for chloroform activation.	Chloroform	90-100	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	28-34
7645016-6	1995	These findings suggest that CYP2E1 is a low Km isoform and CYP2B1/2 a high Km isoform for chloroform activation.	Chloroform	90-100	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	59-65
7645016-10	1995	Immunoinhibition and immunoblot analyses showed that the high dose of chloroform induced CYP2E1 in control rats but decreased CYP2B1/2 in all pretreated rats.	Chloroform	70-80	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	89-95
7645016-10	1995	Immunoinhibition and immunoblot analyses showed that the high dose of chloroform induced CYP2E1 in control rats but decreased CYP2B1/2 in all pretreated rats.	Chloroform	70-80	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	126-132
7645016-11	1995	These results suggest that although both CYP2E1 and CYP2B1/2 contribute to chloroform-induced hepatic damage, they do so quite differently.	Chloroform	75-85	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	41-47
7645016-11	1995	These results suggest that although both CYP2E1 and CYP2B1/2 contribute to chloroform-induced hepatic damage, they do so quite differently.	Chloroform	75-85	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	52-58
7624875-7	1995	Finally, with microsomes, the inactivation was larger with CCl4 (CO binding, 58%; haem assay, 50%; porphyrin fluorescence, 33%) than with CCl3Br (CO binding, 33%; haem assay, 10%) or CHCl3 (haem assay, 9%; CO binding, 6%).	Chloroform	183-188	C-C motif chemokine ligand 4	Homo sapiens	59-63
7624875-9	1995	A correlation between potential for free radical formation (CCl3Br > CCl4 > CHCl3 > CH2Cl2) and extent of haem inactivation was observed with all methods for Hb, but not for microsomal P-450 or MHA.	Chloroform	82-87	C-C motif chemokine ligand 4	Homo sapiens	72-76
7945370-8	1994	The inhibitor was destroyed by treatment with DNase I and resisted phenol-chloroform extraction.	Chloroform	74-84	deoxyribonuclease-1	Oryctolagus cuniculus	46-53
7925454-4	1994	The purified protein P15, identified by N-terminal sequence analysis, showed a strong lytic activity against chloroform-treated Gram-negative cells.	Chloroform	109-119	muramidase	Enterobacteria phage PRD1	21-24
7645016-0	1995	Different contributions of cytochrome P450 2E1 and P450 2B1/2 to chloroform hepatotoxicity in rat.	Chloroform	65-75	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	27-46
7645016-1	1995	The contribution of cytochrome P450 isozymes CYP2E1 and CYP2B1/2 to chloroform-induced hepatotoxicity taken at 18 hr after the treatment was investigated in rats treated with n-hexane as an inducer of CYP2E1, 2-hexanone as an inducer of CYP2E1 and CYP2B1/2, and phenobarbital (PB) as an inducer of CYP2B1/2.	Chloroform	68-78	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	45-51
7645016-1	1995	The contribution of cytochrome P450 isozymes CYP2E1 and CYP2B1/2 to chloroform-induced hepatotoxicity taken at 18 hr after the treatment was investigated in rats treated with n-hexane as an inducer of CYP2E1, 2-hexanone as an inducer of CYP2E1 and CYP2B1/2, and phenobarbital (PB) as an inducer of CYP2B1/2.	Chloroform	68-78	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	56-62
8076368-6	1994	Hyperphosphorylation of p53 may be involved in tumor promotion by benzene, toluene and chloroform.	Chloroform	87-97	tumor protein p53	Homo sapiens	24-27
7765181-3	1994	Tyrosinase was first immobilized in a thin film of water formed on the inner surface of the membrane and then allowed to catalyze p-cresol oxidation in chloroform.	Chloroform	152-162	tyrosinase	Homo sapiens	0-10
8063750-7	1994	PMP2 encodes a 43-amino acid polypeptide that can be extracted from the membrane with chloroform/methanol.	Chloroform	86-96	proteolipid ATPase	Saccharomyces cerevisiae S288C	0-4
8003044-1	1994	New fluorogenic substrate of carboxypeptidase H, Cum-Phe-Ala-Arg-OH, is hydrolyzed by this enzyme to give Cum-Phe-Ala-OH, which is completely extracted by chloroform from the reaction mixture and whose fluorescence increases remarkably by the presence of triethylamine.	Chloroform	155-165	carboxypeptidase E	Homo sapiens	29-47
8179181-2	1994	SP-C was purified from calf lung surfactant extract by gel filtration on LH-20 and LH-60 columns in chloroform:methanol:0.1 N HCl (19:19:2).	Chloroform	100-110	surfactant protein C	Bos taurus	0-4
8177023-4	1994	In the second step, "bound" PAF, i.e., PAF not extractable with ethanol, is extracted from the protein precipitate with chloroform/methanol/water.	Chloroform	120-130	PCNA clamp associated factor	Homo sapiens	28-31
8177023-4	1994	In the second step, "bound" PAF, i.e., PAF not extractable with ethanol, is extracted from the protein precipitate with chloroform/methanol/water.	Chloroform	120-130	PCNA clamp associated factor	Homo sapiens	39-42
8179181-5	1994	Polyacrylamide gel electrophoresis followed by fluorography demonstrated that the intensity of the 14C-labeled SP-C bands correlated with the chloroform-soluble radioactivity.	Chloroform	142-152	surfactant protein C	Bos taurus	111-115
8144421-4	1993	In addition, beta-lactamase released by osmotic shock treatment was found to be unstable during storage at -20 degrees C or during the 18 h period of iso-electric focusing at +4 degrees C. Chloroform treatment produced similar band patterns and at least as good an enzyme yield as ultrasonic disintegration and was equally simple and fast to perform.	Chloroform	189-199	beta-lactamase	Escherichia coli	13-27
8005369-7	1994	Cytochrome P450 loss was significant as early as 3 hr following exposure to BrCCl3, alone or when added with CHCl3.	Chloroform	109-114	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
8259594-4	1993	Twenty-percent chloroform (wt/wt) and a dithizone concentration of 5.0 x 10(-5) M combined in paraffin (TP-2) produced optimal color change from pink to green after > 1500 cGy.	Chloroform	15-25	transition protein 2	Homo sapiens	104-108
7691667-7	1993	Our results provide direct evidence that the epitopes recognized by the MICA are destroyed by methanol/chloroform treatment but reveal a high stability to Pronase digestion compared to proinsulin epitopes.	Chloroform	103-113	MHC class I polypeptide-related sequence A	Homo sapiens	72-76
8397901-5	1993	The workers exposed to chloroform at 29.51 mg/m3 had slight liver damage indicated by the higher rates of abnormal serum prealbumin and transferrin levels than those of control workers.	Chloroform	23-33	transferrin	Rattus norvegicus	136-147
16668783-5	1992	VM 23 was partially extracted from the vacuolar membranes with chloroform:methanol, indicating its high hydrophobicity.	Chloroform	63-73	aquaporin TIP1-2-like	Raphanus sativus	0-5
8437114-3	1993	AHR-16329, a representative sulfamate, has an acidic (sulfonamide, pKa 8.9) and basic (imidazole, pKa 6.0) group and has desirable physicochemical properties for topical intraocular pressure lowering: good water solubility below pH 6.0, a CHCl3/buffer ratio of 0.5 at pH 7.0 and a Kl against CA-II of 7 nM.	Chloroform	239-244	aryl hydrocarbon receptor	Homo sapiens	0-3
8300327-3	1993	An intraperitoneal injection of chloroform markedly stimulates the ODC activity, as in the deficient rat as in the normal animal; the response following stimulation is even relatively higher under avitaminosis A.	Chloroform	32-42	ornithine decarboxylase 1	Rattus norvegicus	67-70
8300327-7	1993	The chloroform stimulation induced relatively a moderate increase in the normal rat (2 fold over baseline level); it is more intense (4 fold) in deficient animal and the ODC activity is well above those of normally fed control in absolute value.	Chloroform	4-14	ornithine decarboxylase 1	Rattus norvegicus	170-173
1418688-3	1992	Among some solvents capable of solubilizing all of the reaction components (PEG-modified CEH, cholesterol, and linoleic acid), chloroform was most suitable for enzymatic cholesterol linoleate synthesis, and the synthetic activity for cholesterol linoleate decreased in the order chloroform, benzene, toluene, and cyclohexane.	Chloroform	127-137	carboxylesterase 1	Homo sapiens	89-92
1453350-7	1992	Chloroform administration strongly enhances liver ODC activity in normal rats.	Chloroform	0-10	ornithine decarboxylase 1	Rattus norvegicus	50-53
1453350-11	1992	Moreover, deficient animals maintain a non negligible capacity of ODC response under chloroform stimulation.	Chloroform	85-95	ornithine decarboxylase 1	Rattus norvegicus	66-69
1332612-2	1992	Fractionation of organic extracts by thin layer chromatography in chloroform/acetone/methanol/acetic acid/water (50/20/10/10/5, v/v) revealed two insulin-sensitive glucosaminyl lipid fractions, the TLC origin (the Rf 0.0 fraction) and a fraction that migrated with Rf 0.18-0.2 (the Rf 0.2 fraction).	Chloroform	66-76	insulin	Homo sapiens	146-153
1354081-1	1992	In this study we demonstrate that chloroform, a widely used industrial solvent, a medicinal chemical and a common drinking water contaminant, reduces the number of detectable preneoplastic enzyme-altered foci [gamma-glutamyltranspeptidase-positive (GGT+) and placental form glutathione S-transferase-positive (GST-P+)] in the liver of male Fischer 344 rats.	Chloroform	34-44	glutathione S-transferase pi 1	Rattus norvegicus	310-315
1616060-5	1992	SP-B partitioned into chloroform-methanol, which was evaporated under N2.	Chloroform	22-32	surfactant protein B	Bos taurus	0-4
1553751-1	1992	It was found that the four toxigenic agents, CCl4, CHCl3, CBrCl3, and 1,1-dichloroethylene (vinylidene chloride) all share the property of activating phospholipase A2 (PLA2) of isolated hepatocytes in suspension, as determined over a 60- or 120-min time period.	Chloroform	51-56	phospholipase A2 group IB	Rattus norvegicus	150-166
1547853-1	1992	The characteristic circular dichroism of bilirubin bound to human serum albumin undergoes a remarkable sign inversion on addition of halothane, chloroform and other volatile anesthetics.	Chloroform	144-154	albumin	Homo sapiens	66-79
1553751-1	1992	It was found that the four toxigenic agents, CCl4, CHCl3, CBrCl3, and 1,1-dichloroethylene (vinylidene chloride) all share the property of activating phospholipase A2 (PLA2) of isolated hepatocytes in suspension, as determined over a 60- or 120-min time period.	Chloroform	51-56	phospholipase A2 group IB	Rattus norvegicus	168-172
1553751-0	1992	Phospholipase A2 activation and cell injury in isolated rat hepatocytes exposed to bromotrichloromethane, chloroform, and 1,1-dichloroethylene as compared to effects of carbon tetrachloride.	Chloroform	106-116	phospholipase A2 group IB	Rattus norvegicus	0-16
1463393-1	1992	The effect of coadministration of CHCl3 on CCl4-induced hepatic damage was investigated at low dose inhalation.	Chloroform	34-39	C-C motif chemokine ligand 4	Rattus norvegicus	43-47
1298167-4	1992	In MDCC-MSB1 cell cultures, a chloroform-resistant virus smaller than 50 nm in diameter, resistant to heating at 70 degrees C for 30 min, and antigenically very closely related to the Cux-1 strain of CAV was isolated from the liver of naturally diseased broilers.	Chloroform	30-40	cut like homeobox 1	Gallus gallus	184-189
1463393-5	1992	These results suggest that the concentration of 10 ppm CCl4 may be significant for CHCl3 to potentiate the hepatic damage caused by CCl4 in ethanol-treated rats.	Chloroform	83-88	C-C motif chemokine ligand 4	Rattus norvegicus	55-59
1463393-5	1992	These results suggest that the concentration of 10 ppm CCl4 may be significant for CHCl3 to potentiate the hepatic damage caused by CCl4 in ethanol-treated rats.	Chloroform	83-88	C-C motif chemokine ligand 4	Rattus norvegicus	132-136
1771271-5	1991	However, because the U.S. Environmental Protection Agency"s (EPA"s) Cancer Potency Factor (CPF) for inhalation of chloroform is much higher than the CPF for ingestion, the ratios of incremental lifetime cancer risk from inhalation of chloroform to risk from ingestion are much larger than the corresponding ratios for dose.	Chloroform	114-124	nuclear receptor subfamily 5 group A member 2	Homo sapiens	68-89
1819701-1	1991	Approximately 75% of the PAF present in saliva is recovered on extraction of whole saliva (0.8 vol) with chloroform/methanol/water (2:2:1, v/v/v).	Chloroform	105-115	PCNA clamp associated factor	Homo sapiens	25-28
1764111-0	1991	Inhibition of vitamin B12-dependent methionine biosynthesis by chloroform and carbon tetrachloride.	Chloroform	63-73	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	22-25
1771271-5	1991	However, because the U.S. Environmental Protection Agency"s (EPA"s) Cancer Potency Factor (CPF) for inhalation of chloroform is much higher than the CPF for ingestion, the ratios of incremental lifetime cancer risk from inhalation of chloroform to risk from ingestion are much larger than the corresponding ratios for dose.	Chloroform	114-124	nuclear receptor subfamily 5 group A member 2	Homo sapiens	91-94
18965293-2	1991	A standard solution of bromine in chloroform was used as titrant and the end-points were detected with a small platinum indicator electrode, and an Ag/AgCl electrode in 0.01M Et(4)NCl in chloroform as reference.	Chloroform	187-197	nucleolin	Homo sapiens	180-183
1658604-2	1991	UV irradiation of TRP resulted in formation of chloroform-soluble photoproducts that can specifically bind to the Ah receptor (AhR), an intracellular protein that mediates the induction of AHH activity by xenobiotics.	Chloroform	47-57	aryl hydrocarbon receptor	Homo sapiens	114-125
1658604-2	1991	UV irradiation of TRP resulted in formation of chloroform-soluble photoproducts that can specifically bind to the Ah receptor (AhR), an intracellular protein that mediates the induction of AHH activity by xenobiotics.	Chloroform	47-57	aryl hydrocarbon receptor	Homo sapiens	127-130
1658604-2	1991	UV irradiation of TRP resulted in formation of chloroform-soluble photoproducts that can specifically bind to the Ah receptor (AhR), an intracellular protein that mediates the induction of AHH activity by xenobiotics.	Chloroform	47-57	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	189-192
1812278-6	1991	The active principles for the protection of CCl4-induced liver injury were recognized in a fraction (EF 3-3) obtained by using silica gel chromatography (solvent: CHCl3-MeOH-H2O).	Chloroform	163-168	C-C motif chemokine ligand 4	Rattus norvegicus	44-48
1786015-5	1991	All MAbs reacted in a direct enzyme-linked immunosorbent assay with Cux-1 antigen treated with 0.5% sodium dodecyl sulfate followed by extraction with chloroform, but not with MSB1 cells infected with Cux-1 or chloroform-extracts of these cells.	Chloroform	151-161	cut like homeobox 1	Gallus gallus	68-73
1786015-5	1991	All MAbs reacted in a direct enzyme-linked immunosorbent assay with Cux-1 antigen treated with 0.5% sodium dodecyl sulfate followed by extraction with chloroform, but not with MSB1 cells infected with Cux-1 or chloroform-extracts of these cells.	Chloroform	210-220	cut like homeobox 1	Gallus gallus	68-73
2027905-1	1991	Extraction of a solution of bilirubin configurational isomers in chloroform with an aqueous solution of human serum albumin was found to remove selectively the 4Z,15E-isomer.	Chloroform	65-75	albumin	Homo sapiens	110-123
1777966-5	1991	Extraction of saliva with chloroform/methanol/water resulted in 70-90% recovery of PAF.	Chloroform	26-36	PCNA clamp associated factor	Homo sapiens	83-86
1884917-1	1991	Previous studies have demonstrated that various compounds, including the common groundwater contaminants trichloroethylene (TCE) and chloroform (CHCl3), can produce a synergistic toxic response when coadministered with the model hepatotoxicant carbon tetrachloride (CCl4).	Chloroform	133-143	C-C motif chemokine ligand 4	Rattus norvegicus	266-270
1884917-1	1991	Previous studies have demonstrated that various compounds, including the common groundwater contaminants trichloroethylene (TCE) and chloroform (CHCl3), can produce a synergistic toxic response when coadministered with the model hepatotoxicant carbon tetrachloride (CCl4).	Chloroform	145-150	C-C motif chemokine ligand 4	Rattus norvegicus	266-270
1884917-10	1991	Although none of the pretreatments were detectably hepatoxic, rats which drank 15 and 40 mM TCE or 8 mM CHCl3 exhibited an enhanced response to CCl4.	Chloroform	104-109	C-C motif chemokine ligand 4	Rattus norvegicus	144-148
1915590-2	1991	Chloroform, benzyl alcohol and ethanol all partially activated PKC.	Chloroform	0-10	proline rich transmembrane protein 2	Homo sapiens	63-66
1915590-5	1991	Chloroform was the most potent activator stimulating PKC phosphotransferase activity up to a level 40% of that obtained by the endogenous activator, diacylglycerol.	Chloroform	0-10	proline rich transmembrane protein 2	Homo sapiens	53-56
2001359-1	1991	In an earlier publication, we reported that corrinoids catalyze the sequential reduction of CCl4 to CHCl3, CH2Cl2, CH3Cl, and CH4 with titanium(III) citrate as electron donor [Krone, U. E., Thauer, R. K., & Hogenkamp, H. P. C. (1989) Biochemistry 28, 4908-4914].	Chloroform	100-105	C-C motif chemokine ligand 4	Homo sapiens	92-96
1979609-11	1990	Pf of endosomes containing the VP-sensitive water channel decreased fourfold by increasing membrane fluidity with hexanol or chloroform (0-75 mM); Pf of phosphatidylcholine liposomes (0.002 cm/s) increased 2.5-fold under the same conditions.	Chloroform	125-135	arginine vasopressin	Homo sapiens	31-33
2287784-0	1990	Routes of chloroform exposure and body burden from showering with chlorinated tap water.	Chloroform	10-20	nuclear RNA export factor 1	Homo sapiens	78-81
2076453-3	1990	When a substrate (ethanol) in the oil phase of toluene or chloroform slowly migrated into the aqueous phase containing alcohol dehydrogenase and NAD+, oscillations were observed in the concentration of NADH produced.	Chloroform	58-68	aldo-keto reductase family 1 member A1	Homo sapiens	119-140
1696624-1	1990	Myelin basic protein (MBP) from the Whaler shark (Carcharhinus obscurus) has been purified from acid extracts of a chloroform/methanol pellet from whole brains.	Chloroform	115-125	myelin basic protein	Bos taurus	22-25
2386812-10	1990	The conformation obtained from the MD simulation in CCl4 nicely agrees with experimental atom-atom distance data as obtained from nmr experiments in chloroform.	Chloroform	149-159	C-C motif chemokine ligand 4	Homo sapiens	52-56
2397486-1	1990	Liver nuclear preparations from male Syrian Golden hamster (SG); C3H mice and Sprague-Dawley (SD) rats were able to biotransform CCl4 to CHCl3.	Chloroform	137-142	C-C motif chemokine ligand 4	Rattus norvegicus	129-133
2397486-4	1990	There was a correlation between liver nuclear ability to biotransform CCl4 to CHCl3 in the species tested and their liver carcinogenic response to CCl4.	Chloroform	78-83	chemokine (C-C motif) ligand 4	Mus musculus	70-74
2397486-4	1990	There was a correlation between liver nuclear ability to biotransform CCl4 to CHCl3 in the species tested and their liver carcinogenic response to CCl4.	Chloroform	78-83	chemokine (C-C motif) ligand 4	Mus musculus	147-151
2191770-1	1990	The frequency and mutational profile of H-ras gene activation were determined in spontaneous liver tumors of male C57BL/6 x C3H/He mice and in tumors induced with the genotoxic hepatocarcinogen benzidine.2 HCl or the nongenotoxic hepatocarcinogens phenobarbital, chloroform, and ciprofibrate.	Chloroform	263-273	Harvey rat sarcoma virus oncogene	Mus musculus	40-45
2135368-7	1990	Virus infectivity as measured by CPE was sensitive to chloroform and not inhibited by BuDR, suggesting that agent is an enveloped virus with RNA genome.	Chloroform	54-64	carboxypeptidase E	Homo sapiens	33-36
2104489-6	1990	Extracted by CHCl3:CH3OH:H2O (2:2:1.8), separated by thin layer chromatography (TLC) and determined by liquid scintillation counting, PAF released was inhibited significantly by Dau both in time (10-30 min) and dose (1-1000 mumol/L) dependent manners.	Chloroform	13-18	patchy fur	Mus musculus	134-137
2310409-4	1990	Results from experiments conducted to determine whether or not the CCl4-induced decrease in MT-thiol content was due to the scavenging of CCl4 metabolite(s) showed that the trichloromethyl radical, chloroform and phosgene as well as the products of CCl4-induced microsomal lipid peroxidation were not directly involved.	Chloroform	173-196	C-C motif chemokine ligand 4	Homo sapiens	67-71
2340978-9	1990	In combination, both CCl4/CHCl3 and CCl4/TCE displayed a synergistic (supraadditive) response for peak plasma enzyme activity.	Chloroform	26-31	C-C motif chemokine ligand 4	Rattus norvegicus	21-25
2310409-4	1990	Results from experiments conducted to determine whether or not the CCl4-induced decrease in MT-thiol content was due to the scavenging of CCl4 metabolite(s) showed that the trichloromethyl radical, chloroform and phosgene as well as the products of CCl4-induced microsomal lipid peroxidation were not directly involved.	Chloroform	173-196	C-C motif chemokine ligand 4	Homo sapiens	138-142
2310409-4	1990	Results from experiments conducted to determine whether or not the CCl4-induced decrease in MT-thiol content was due to the scavenging of CCl4 metabolite(s) showed that the trichloromethyl radical, chloroform and phosgene as well as the products of CCl4-induced microsomal lipid peroxidation were not directly involved.	Chloroform	173-196	C-C motif chemokine ligand 4	Homo sapiens	138-142
2310409-4	1990	Results from experiments conducted to determine whether or not the CCl4-induced decrease in MT-thiol content was due to the scavenging of CCl4 metabolite(s) showed that the trichloromethyl radical, chloroform and phosgene as well as the products of CCl4-induced microsomal lipid peroxidation were not directly involved.	Chloroform	198-208	C-C motif chemokine ligand 4	Homo sapiens	67-71
2310409-4	1990	Results from experiments conducted to determine whether or not the CCl4-induced decrease in MT-thiol content was due to the scavenging of CCl4 metabolite(s) showed that the trichloromethyl radical, chloroform and phosgene as well as the products of CCl4-induced microsomal lipid peroxidation were not directly involved.	Chloroform	198-208	C-C motif chemokine ligand 4	Homo sapiens	138-142
2310409-4	1990	Results from experiments conducted to determine whether or not the CCl4-induced decrease in MT-thiol content was due to the scavenging of CCl4 metabolite(s) showed that the trichloromethyl radical, chloroform and phosgene as well as the products of CCl4-induced microsomal lipid peroxidation were not directly involved.	Chloroform	198-208	C-C motif chemokine ligand 4	Homo sapiens	138-142
20702219-8	1990	Analysis of glutathione depletion/concentration relationships demonstrated that P-450j has high affinity for chloroform, as judged by reactive metabolite formation.	Chloroform	109-119	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	80-86
25016301-7	2014	The relative significance of lignin phenols as chlorination DBP precursors generally follows the order of TCAA > DCAA&chloroform.	Chloroform	125-135	D-box binding PAR bZIP transcription factor	Homo sapiens	60-63
25724770-5	2015	DLPC was dispersed in a chloroform/methanol mixture that was spread on a free PLA2 solution surface.	Chloroform	24-34	phospholipase A2 group IIA	Homo sapiens	78-82
25016301-8	2014	The relative significance of lignin phenols to DBP formation by chloramination follows the order: TCAA > DCAA&DCAN > chloroform.	Chloroform	127-137	D-box binding PAR bZIP transcription factor	Homo sapiens	47-50
34821331-6	2021	The unique conformation of the DCB core endows DCB-4F with higher solubility (8.2 mg mL-1 in chloroform) compared to CB-4F (2.2 mg mL-1) when using the same side chains.	Chloroform	93-103	L1 cell adhesion molecule	Mus musculus	85-89
34310880-2	2021	The nonmetalated host, H6L, was found to bind to alkali metal ions (Na+, K+, Rb+, Cs+; logKa = 3.37-6.67) in its well-defined cavity in DMSO/chloroform (1:9).	Chloroform	141-151	H6 family homeobox 2	Homo sapiens	23-26
34110164-3	2021	We studied the molecular combing of a series of poly(n-alkyl acrylate)s on mica from a chloroform solution by the dipping method and found that poly(n-alkyl acrylate)s with an alkyl group longer than n-octyl can be molecularly combed into straight chains under optimized conditions.	Chloroform	87-97	MHC class I polypeptide-related sequence A	Homo sapiens	75-79
34832937-12	2021	According to the different antioxidant mechanisms, hexane and chloroform fractions showed the highest antioxidant activities by FRAP and ORAC assays, respectively.	Chloroform	62-72	mechanistic target of rapamycin kinase	Homo sapiens	128-132
34415151-3	2021	In this context, we have investigated the conformational disorder effect on the real-time photobleaching kinetics of a poly(2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene) (MEH-PPV)/chloroform solution under deep-blue radiation.	Chloroform	187-197	epoxide hydrolase 1	Homo sapiens	178-181
34415151-7	2021	Consequently, the effective conjugation length of MEH-PPV in chloroform decreases from nine to three coplanar repetitive units after 1 h of excitation, producing a drastic drop in photoluminescence.	Chloroform	61-71	epoxide hydrolase 1	Homo sapiens	50-53
34225246-9	2021	METHODS: The chloroform (CHL) extracts are prepared from blossoms of CAVA by fractional extraction and are characterized using LC-MS assay.	Chloroform	13-23	carbonic anhydrase 5a, mitochondrial	Mus musculus	69-73
34323033-2	2021	Methods: The formulation of insulin-loaded water-in-oil-in-water solid lipid nanoparticles (INS-SNPs) was prepared by using a methanol-chloroform mixed solvent.	Chloroform	135-145	insulin	Homo sapiens	28-35
34190801-9	2021	Our results about bacterial cell protein leakage indicated that MDR isolates treated with chloroform extract of Fagonia indica showed maximum protein leakage of K. pneumoniae (59.14 microg mL-1) followed by S. aureus (56.7 microg mL-1).	Chloroform	90-100	L1 cell adhesion molecule	Mus musculus	189-193
34190801-9	2021	Our results about bacterial cell protein leakage indicated that MDR isolates treated with chloroform extract of Fagonia indica showed maximum protein leakage of K. pneumoniae (59.14 microg mL-1) followed by S. aureus (56.7 microg mL-1).	Chloroform	90-100	L1 cell adhesion molecule	Mus musculus	230-234
35124083-2	2022	The produced material has a feather-like morphology, and its adsorption of some chlorinated volatile organic compounds (Cl-VOC"s) such as benzyl chloride, chloroform and carbon tetrachloride (C7H7Cl, CHCl3 and CCl4) was investigated due to their potential carcinogenic effect on humans.	Chloroform	200-205	C-C motif chemokine ligand 4	Homo sapiens	210-214
34275853-8	2021	COX-2 inhibition was calculated which was high in RME (68.69%), ethyl acetate (56.52%), aqueous (55.21%) and chloroform fraction (53.47%).	Chloroform	109-119	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-5
35229900-6	2022	The phenol-chloroform method achieved a significantly higher frequency of cox1 gene amplification.	Chloroform	11-21	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	74-78
35597374-3	2022	Owing to the introduction of CS, the hydrogel displayed excellent nonswelling properties under aqueous solutions (pH = 1, 4 and 7), physiological saline, seawater, dodecane, n-hexane and chloroform.	Chloroform	187-197	citrate synthase	Homo sapiens	29-31
34908079-1	2022	In this study we self-assembled the four-armed porphyrin hetero dimer capsule Cap4, stabilized through amidinium-carboxylate salt bridges, in CH2Cl2 and CHCl3.	Chloroform	153-158	caspase 8	Homo sapiens	78-82
35414160-9	2022	The likely distribution of a few prominent NMVOC species in different environmental compartments, simulated by multimedia mass balance model TaPL3 (3.0), showed that almost the entire dissolved chloroform would be emitted to atmosphere (98%), followed by benzene (71%), in contrast to xylene that would primarily get partitioned into canal sediment (53%).	Chloroform	194-204	nuclear RNA export factor 3	Homo sapiens	141-146
35266945-6	2022	The syn-anti isomerization (epimerization) of the isolated complexes in chloroform was disclosed.	Chloroform	72-82	synemin	Homo sapiens	4-7
35237756-4	2022	Among the crude extract and its fractions, chloroform fraction exerted strong inhibition of acetylcholinesterase and butyrylcholinesterase enzymes with IC50 values of 40.06 and 18.78 microg/mL, respectively.	Chloroform	43-53	acetylcholinesterase	Mus musculus	92-112
35237756-10	2022	The chloroform fraction also significantly reduced the activity of acetylcholinesterase and oxidative stress in mice.	Chloroform	4-14	acetylcholinesterase	Mus musculus	67-87
35125087-15	2022	The bioassay guided isolation afforded four molecules AC-1 to AC-4 from chloroform fraction.	Chloroform	72-82	long intergenic non-protein coding RNA 1587	Homo sapiens	64-66
35448395-6	2022	Chloroform-based MMMs containing 10 and 30 wt.% MOF-808 showed 73% and 62% increase in CO2 permeability, respectively, without a decrease in separation factor compared to unfilled membranes.	Chloroform	0-10	lysine acetyltransferase 8	Homo sapiens	48-51
35424639-5	2022	The results show that, when the mass ratio of chloroform/ethanol is around 75/25, the rapid "in situ" formation of the PLA fibers can be realized with porous structures within 5-10 s. The establishment of a "nonsolvent-solvent-polymer" ternary phase diagram model has laid a theoretical foundation for the rapid formation of polymer porous fibers by ESP-NIPS.	Chloroform	46-56	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	350-353
35103263-4	2022	Here we describe the VCD spectroscopic characterization of the model peptide Boc-Val-Phe-nPr in chloroform as representative for a weakly interacting solvent and dimethyl sulfoxide (DMSO-d6) as a strongly hydrogen bonding solvent.	Chloroform	96-106	neuronal pentraxin receptor	Homo sapiens	89-92
2559772-10	1989	The kinetics of CHCl3 and CH2Cl2 formation from CCl4 were similar to those with coenzyme F430 or aquocobalamin as catalysts and titanium(III) citrate as the reductant.	Chloroform	16-21	C-C motif chemokine ligand 4	Homo sapiens	48-52
2531033-3	1989	The cytotoxic activity was recovered in the chloroform fraction of a Bligh-Dyer lipid extraction suggesting that the toxic moiety in the CD16+ NK cell-derived supernatants might be a lipid.	Chloroform	44-54	Fc gamma receptor IIIa	Homo sapiens	137-141
2628543-4	1989	In contrast to other haem-bromoperoxidases, the bromoperoxidase-catalase was stable when treated with an ethanol/chloroform mixture.	Chloroform	113-123	SVEN_RS24125	Streptomyces venezuelae ATCC 10712	48-72
2478540-7	1989	The HUVEC-derived kallikrein inhibitory activity was mostly C1 INH because it was reversed by chemically treating the lysate with chloroform and was neutralized by anti-C1 INH antibody.	Chloroform	130-140	kallikrein related peptidase 4	Homo sapiens	18-28
2478540-7	1989	The HUVEC-derived kallikrein inhibitory activity was mostly C1 INH because it was reversed by chemically treating the lysate with chloroform and was neutralized by anti-C1 INH antibody.	Chloroform	130-140	serpin family G member 1	Homo sapiens	60-66
2677012-2	1989	HDGF was purified from bovine myocardium using a procedure that involves denaturation of undesired proteins with methanol and chloroform.	Chloroform	126-136	heparin binding growth factor	Bos taurus	0-4
2818611-1	1989	Bovine liver dihydrofolate reductase has been solubilized in reverse micelles of cationic surfactant cetyltrimethylammonium bromide (CTAB) in isooctane-chloroform (1:1,V/V) mixture.	Chloroform	152-162	dihydrofolate reductase	Bos taurus	13-36
2735913-4	1989	These data are consistent with the hypothesis that the "alcohol-inducible" form of cytochrome P-450 is capable of CCl4- but not CHCl3-activation.	Chloroform	128-133	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	83-99
2475409-2	1989	Therefore some haematological parameters were investigated after oral administration of CCl4 and the CCl4-metabolite chloroform in rats.	Chloroform	117-127	C-C motif chemokine ligand 4	Rattus norvegicus	101-105
2502043-3	1989	Through the use of urea, chloroform, and ethanol in appropriate concentrations, apolipoproteins A-I and A-II were isolated by a simple extraction technique avoiding time-consuming ultracentrifugation.	Chloroform	25-35	apolipoprotein A1	Homo sapiens	80-108
2650039-4	1989	Chloroform is discussed as an example of cytochrome P-450-mediated activation and dihaloethanes and hexachloro-1,3-butadiene as examples of glutathione conjugation followed by activation.	Chloroform	0-10	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	41-57
2747250-2	1989	A chloroform extract of the nut significantly reduced acute carrageenan-induced paw oedema in rats and was active against the secondary lesions of adjuvant-induced arthritis.	Chloroform	2-12	NUT midline carcinoma, family member 1	Rattus norvegicus	28-31
18620263-6	1989	Estimates of the bound water content of tardigrades by DSC show that this can account for the dehydrated masses of these chloroform-rinsed animals and that all free water is probably transpired.	Chloroform	121-131	desmocollin 3	Homo sapiens	55-58
2724368-1	1989	The role of glutathione (GSH) and ornithine decarboxylase-antizyme (ODC-AZ) in the regulation of the chloroform-mediated stimulation of rat hepatic ornithine decarboxylase (ODC) was investigated.	Chloroform	101-111	ornithine decarboxylase antizyme 1	Rattus norvegicus	68-74
2724368-1	1989	The role of glutathione (GSH) and ornithine decarboxylase-antizyme (ODC-AZ) in the regulation of the chloroform-mediated stimulation of rat hepatic ornithine decarboxylase (ODC) was investigated.	Chloroform	101-111	ornithine decarboxylase 1	Rattus norvegicus	34-57
2724368-1	1989	The role of glutathione (GSH) and ornithine decarboxylase-antizyme (ODC-AZ) in the regulation of the chloroform-mediated stimulation of rat hepatic ornithine decarboxylase (ODC) was investigated.	Chloroform	101-111	ornithine decarboxylase 1	Rattus norvegicus	68-71
2724368-3	1989	In this study we examined the effect of pretreatment with diethyl maleate (DEM), a GSH-depleting agent, on the chloroform stimulation of the two forms of the rat hepatic ODC enzyme and the sensitivity of these two forms to inhibition by the ODC-AZ.	Chloroform	111-121	ornithine decarboxylase 1	Rattus norvegicus	170-173
2724368-4	1989	While the pretreatment with DEM provided a greater amount of the two forms of the ODC enzyme, it also resulted in a differential stimulation of each form when compared to chloroform alone.	Chloroform	171-181	ornithine decarboxylase 1	Rattus norvegicus	82-85
2724368-0	1989	Chloroform-induced multiple forms of ornithine decarboxylase: differential sensitivity of forms to enhancement by diethyl maleate and inhibition by ODC-antizyme.	Chloroform	0-10	ornithine decarboxylase 1	Rattus norvegicus	37-60
2724368-0	1989	Chloroform-induced multiple forms of ornithine decarboxylase: differential sensitivity of forms to enhancement by diethyl maleate and inhibition by ODC-antizyme.	Chloroform	0-10	ornithine decarboxylase 1	Rattus norvegicus	148-151
3222528-0	1988	Chloroform mediated refractory state against ornithine decarboxylase induction by serial chloroform treatment.	Chloroform	0-10	ornithine decarboxylase 1	Rattus norvegicus	45-68
3192678-2	1988	SOD activity was measured by pyrogallol assay in ethanol-chloroform extracts of the thyroid homogenates.	Chloroform	57-67	superoxide dismutase 1	Homo sapiens	0-3
3232318-6	1988	Deproteinization of CA-1 with chloroform and butanol followed by pronase treatment resulted in failure to protect mice from death.	Chloroform	30-40	carbonic anhydrase 1	Mus musculus	20-24
2567070-4	1989	At 54 and 160 mg/kg, chloroform increased hepatic ODC activity with minimal or no elevation in SGPT activity.	Chloroform	21-31	ornithine decarboxylase 1	Rattus norvegicus	50-53
2567070-5	1989	At 480 mg/kg chloroform increased hepatic ODC and SGPT activity.	Chloroform	13-23	ornithine decarboxylase 1	Rattus norvegicus	42-45
3222528-0	1988	Chloroform mediated refractory state against ornithine decarboxylase induction by serial chloroform treatment.	Chloroform	89-99	ornithine decarboxylase 1	Rattus norvegicus	45-68
3222528-1	1988	The chloroform mediated refractory state against ornithine decarboxylase induction in male and female rat liver was further studied.	Chloroform	4-14	ornithine decarboxylase 1	Rattus norvegicus	49-72
3132521-2	1988	Treatment of ether phospholipids in chloroform with BCl3 for 30 min at room temperature yielded almost quantitatively the corresponding glycerophosphoesters retaining the intact polar head group of the ether phospholipids.	Chloroform	36-46	BCL3 transcription coactivator	Homo sapiens	52-56
3183290-7	1988	However, when tested with CHCl3 (CHCl3 and CCl4-85:15), the mutagenic capability was lost.	Chloroform	26-31	C-C motif chemokine ligand 4	Homo sapiens	43-47
2832723-1	1988	CCl4 has been shown previously to be metabolized to the trichloromethyl radical (.CCl3) and to a novel oxygen-containing carbon dioxide anion radical (.CO2-) in the perfused rat liver and in vivo.	Chloroform	56-79	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
3145372-3	1988	A simple chloroform extraction process has been developed which eliminates several of the interfering factors from plasma samples and increases the amount of IL-1 beta detected by radioimmunoassay and lymphocyte activation assay.	Chloroform	9-19	interleukin 1 beta	Homo sapiens	158-167
2964865-1	1987	The bovine mitochondrial gene products ND2 and ND4, components of NADH dehydrogenase, have been purified from a chloroform/methanol extract of mitochondrial membranes, and the human mitochondrial gene products ND2 and cytochrome b have been obtained by similar procedures.	Chloroform	112-122	NADH dehydrogenase subunit 2	Bos taurus	39-42
2964865-1	1987	The bovine mitochondrial gene products ND2 and ND4, components of NADH dehydrogenase, have been purified from a chloroform/methanol extract of mitochondrial membranes, and the human mitochondrial gene products ND2 and cytochrome b have been obtained by similar procedures.	Chloroform	112-122	NADH dehydrogenase subunit 4	Bos taurus	47-50
3431551-10	1987	In addition, MEF partitioned to the aqueous phase during methanol-chloroform extraction procedures.	Chloroform	66-76	E74 like ETS transcription factor 4	Homo sapiens	13-16
3476960-6	1987	The membrane FBP, following delipidation with chloroform/methanol, contained 7.1 mol of fatty acid per mol of protein, of which 4.7 mol was amide-linked and 2.4 mol was ester-linked.	Chloroform	46-56	folate receptor beta	Homo sapiens	13-16
3104120-9	1987	The relationship between sensitivity to the hepatotoxic effects of CHCl3 and CCl4 was different for the gerbil and rat.	Chloroform	67-72	C-C motif chemokine ligand 4	Rattus norvegicus	77-81
3029264-2	1987	The G6PD-stimulating activity of both hypothalamic extract and plasma is soluble in water and insoluble in chloroform.	Chloroform	107-117	glucose-6-phosphate dehydrogenase	Rattus norvegicus	4-8
3805022-1	1987	The ligatin monomer is a polypeptide of Mr = 10,000 which is soluble in acidified chloroform:methanol, a characteristic similar to that of Folch-Lee proteolipid.	Chloroform	82-92	ligatin	Homo sapiens	4-11
2852264-4	1988	The chloroform layer was applied to an open silica gel column, and at a fraction with ethylacetate: methanol (60: 40, T-1 fraction), DLS and ATPI were eluted at the highest concentration.	Chloroform	4-14	ATP synthase inhibitory factor subunit 1	Rattus norvegicus	141-145
3143166-14	1988	The simplest kinetic explanation of the metabolite time course is that 4% of the initially metabolized CCl4 is directly converted to CO2 (probably via a chloroform intermediate) and the remainder of metabolized CCl4 binds to biological substrates.	Chloroform	153-163	C-C motif chemokine ligand 4	Rattus norvegicus	103-107
2464071-2	1988	Rapid and efficient separation of labelled PLP from other proteins and lipids was effected by extraction into chloroform/methanol/0.1 N HCl (10/10/1) and chromatography on Sephadex LH-60 in the same solvent.	Chloroform	110-120	proteolipid protein 1	Homo sapiens	43-46
3418748-0	1988	Chloroform induction of ornithine decarboxylase antizyme (ODC-AZ) in male rat liver.	Chloroform	0-10	ornithine decarboxylase antizyme 1	Rattus norvegicus	24-56
3418748-0	1988	Chloroform induction of ornithine decarboxylase antizyme (ODC-AZ) in male rat liver.	Chloroform	0-10	ornithine decarboxylase antizyme 1	Rattus norvegicus	58-64
3418748-1	1988	Chloroform stimulation of rat hepatic ODC is most dramatic at 18 h following a single injection.	Chloroform	0-10	ornithine decarboxylase 1	Rattus norvegicus	38-41
3418748-6	1988	Chloroform induced ODC-AZ activity in males at 3 and 7 d (26% and 37% inhibition of the ODC activity in the incubation medium, respectively).	Chloroform	0-10	ornithine decarboxylase antizyme 1	Rattus norvegicus	19-25
3418748-6	1988	Chloroform induced ODC-AZ activity in males at 3 and 7 d (26% and 37% inhibition of the ODC activity in the incubation medium, respectively).	Chloroform	0-10	ornithine decarboxylase 1	Rattus norvegicus	19-22
3418748-8	1988	Thus, it would appear that daily exposure of rats to chloroform results in a refractoriness of its induction of ODC activity accompanied by an induction of the ODC-AZ in males.	Chloroform	53-63	ornithine decarboxylase 1	Rattus norvegicus	112-115
3418748-8	1988	Thus, it would appear that daily exposure of rats to chloroform results in a refractoriness of its induction of ODC activity accompanied by an induction of the ODC-AZ in males.	Chloroform	53-63	ornithine decarboxylase antizyme 1	Rattus norvegicus	160-166
3322284-3	1987	DCX was purified by preparative thin layer chromatography from chloroform: methanol = 4:1 extracts of whole bacteria, and is chromatographically homogeneous.	Chloroform	63-73	doublecortin	Homo sapiens	0-3
3432737-0	1987	Studies on the mechanism of action of chloroform stimulation of rat hepatic ornithine decarboxylase (ODC).	Chloroform	38-48	ornithine decarboxylase 1	Rattus norvegicus	76-99
3432737-0	1987	Studies on the mechanism of action of chloroform stimulation of rat hepatic ornithine decarboxylase (ODC).	Chloroform	38-48	ornithine decarboxylase 1	Rattus norvegicus	101-104
3432737-1	1987	We have previously reported that chloroform is a very potent stimulator of rat hepatic Ornithine Decarboxylase (ODC) activity.	Chloroform	33-43	ornithine decarboxylase 1	Rattus norvegicus	87-110
3432737-1	1987	We have previously reported that chloroform is a very potent stimulator of rat hepatic Ornithine Decarboxylase (ODC) activity.	Chloroform	33-43	ornithine decarboxylase 1	Rattus norvegicus	112-115
2822029-1	1987	Stimulation of human or rabbit platelets with thrombin in the presence of fibrinogen caused a large decrease, compared with unstimulated controls, in the amount of phosphatidylinositol 4,5-bisphosphate (PIP2) that could be extracted with acidified chloroform/methanol (60% at 60 s).	Chloroform	248-258	prothrombin	Oryctolagus cuniculus	46-54
2822029-1	1987	Stimulation of human or rabbit platelets with thrombin in the presence of fibrinogen caused a large decrease, compared with unstimulated controls, in the amount of phosphatidylinositol 4,5-bisphosphate (PIP2) that could be extracted with acidified chloroform/methanol (60% at 60 s).	Chloroform	248-258	fibrinogen beta chain	Homo sapiens	74-84
3816733-8	1986	These results suggest that: in mouse hepatocytes, both CHCl3 and CCl4 are metabolized to toxic components by the MFOS; GSH plays a role in detoxifying those metabolites; free radicals are produced during the metabolism of CHCl3 and CCl4; and free radicals may be important mediators of the toxicity of these two halomethanes.	Chloroform	55-60	chemokine (C-C motif) ligand 4	Mus musculus	232-236
2828133-3	1987	Ubiquitin has been isolated from bovine erythrocytes by procedures in which the hemoglobin was removed by denaturation with either ethanol-chloroform mixtures or by heating.	Chloroform	139-149	ubiquitin	Bos taurus	0-9
2948556-1	1986	The stoichiometry and dissociation constants for the interaction of tetracaine with chloroform-released ATPase prepared from beef heart mitochondria were determined from the enhancement of tetracaine fluorescence intensity that occurs upon binding.	Chloroform	84-94	dynein axonemal heavy chain 8	Homo sapiens	104-110
3816733-8	1986	These results suggest that: in mouse hepatocytes, both CHCl3 and CCl4 are metabolized to toxic components by the MFOS; GSH plays a role in detoxifying those metabolites; free radicals are produced during the metabolism of CHCl3 and CCl4; and free radicals may be important mediators of the toxicity of these two halomethanes.	Chloroform	222-227	chemokine (C-C motif) ligand 4	Mus musculus	65-69
3816733-8	1986	These results suggest that: in mouse hepatocytes, both CHCl3 and CCl4 are metabolized to toxic components by the MFOS; GSH plays a role in detoxifying those metabolites; free radicals are produced during the metabolism of CHCl3 and CCl4; and free radicals may be important mediators of the toxicity of these two halomethanes.	Chloroform	222-227	chemokine (C-C motif) ligand 4	Mus musculus	232-236
3707616-2	1986	The administration of CHCl3 hardly affected cytochrome P450 content in non-treated rat liver, but caused a similar degree of depletion in the content as observed after CCl4 administration in PB-pretreated rats.	Chloroform	22-27	C-C motif chemokine ligand 4	Rattus norvegicus	168-172
3745175-1	1986	A protein termed endozepine (EP) which inhibits the binding of benzodiazepines to synaptosomal membranes (Ki approximately 5 microM) has been purified to electrophoretic homogeneity from bovine and human brain using acidic ethanol/chloroform extraction, Bio-Sil TSK-250 gel permeation chromatography, and reverse-phase high performance liquid chromatographies.	Chloroform	231-241	diazepam binding inhibitor, acyl-CoA binding protein	Bos taurus	29-31
3799198-4	1986	Determinations of chloroform:water partition coefficients showed that lipophilic complexes are formed at equilibrations between Ni2+ or Cd2+ and zinc pyridinethione.	Chloroform	18-28	CD2 antigen	Mus musculus	136-139
3697522-0	1986	Chloroform in tap water and human blood.	Chloroform	0-10	nuclear RNA export factor 1	Homo sapiens	14-17
3954800-7	1986	However, the chloroform extractable metabolites were found inactive in vitro towards this enzyme, suggesting that MAO inhibitory activity is mediated by one or more other non-identified metabolites.	Chloroform	13-23	monoamine oxidase A	Rattus norvegicus	114-117
3949114-7	1986	Hyperbaric O2 treatment inhibited in vivo conversion of CCl4 to its volatile metabolites CHCl3 and CO2 by 52% in the 10 h following CCl4 dosing.	Chloroform	89-94	C-C motif chemokine ligand 4	Rattus norvegicus	56-60
3840765-4	1985	The mean chloroform solubility of the biliary radioactivity increased from 17.0 +/- 8.4% to 69.4 +/- 15.1% after incubation with beta-glucuronidase.	Chloroform	9-19	glucuronidase beta	Homo sapiens	129-147
2869658-1	1985	Acidic chloroform-methanol soluble proteins possessing hydrophobic properties and capable of inhibiting in vitro transcriptase activity of influenza virus RNP were detected in native and partially purified human leukocyte interferon (IFN) preparations.	Chloroform	7-17	interferon alpha 1	Homo sapiens	212-238
3000632-3	1985	A significant reduction in the signal intensity was also produced by the addition of cytochrome P-450 inhibitors such as SKF-525A, metyrapone and carbon monoxide, indicating that free radical formation depended upon the reductive metabolism of chloroform mediated by the mixed oxidase system.	Chloroform	244-254	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	85-101
3956332-3	1986	Chloroform solubility of biliary radioactivity increased from 27.4 +/- 8.9% to 72.9 +/- 10.1% following incubation with beta-glucuronidase.	Chloroform	0-10	glucuronidase beta	Homo sapiens	120-138
3954332-2	1986	In contrast, chloroform/methanol extracted 3T3 cells inhibited the plating efficiency of neuroblastoma cells to the same extent as had been the case with living 3T3 cells.	Chloroform	13-23	Rho guanine nucleotide exchange factor (GEF) 16	Mus musculus	89-102
3917040-1	1985	The infrared absorption and 1H nuclear magnetic resonance analyses of chloroform solutions of the terminally-blocked segment corresponding to the 2-9 sequence of emerimicins III and IV, -(Aib)3-L-Val-Gly-L-Leu-(Aib)2-, are consistent with the presence of a 3(10)-helical structure of high thermal stability.	Chloroform	70-80	ANIB3	Homo sapiens	188-193
4067921-5	1985	All the embryo-derived PAF was found in the chloroform fraction after chloroform:methanol (2:1 v/v) extraction, as was PAF-acether.	Chloroform	44-54	patchy fur	Mus musculus	23-26
4067921-5	1985	All the embryo-derived PAF was found in the chloroform fraction after chloroform:methanol (2:1 v/v) extraction, as was PAF-acether.	Chloroform	70-80	patchy fur	Mus musculus	23-26
3987892-1	1985	Treatment of rats with ethanol or rabbits with either imidazole or pyrazole, agents known to induce the ethanol-inducible form of liver microsomal cytochrome P-450 (P-450 LMeb), caused, compared to controls, 3-25-fold enhanced rates of CCl4-dependent lipid peroxidation or chloroform production in isolated liver microsomes.	Chloroform	273-283	cytochrome P-450	Oryctolagus cuniculus	147-163
4085088-2	1985	Removal of the protective group by treatment with HCl in chloroform was followed by subsequent reaction with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) to form the fluorescent analogue of phosphatidylcholine, 1-oleoyl-2-(NBD)aminocaproyl-sn-glycero-3-phosphocholine, in good yield and with high isomeric purity.	Chloroform	57-67	OXA1L mitochondrial inner membrane protein	Homo sapiens	133-138
3988832-4	1985	Chloroform washing removes nearly all the 14C from [14C]IAP.	Chloroform	0-10	magnesium transporter 1	Homo sapiens	56-59
4083034-4	1985	Plasma BuChE activity increase was found to be a common reaction after exposure to TCE, perchloroethylene, chloroform, methylene chloride and carbon tetrachloride and also after exposure to ethanol.	Chloroform	107-117	butyrylcholinesterase	Mus musculus	7-12
4073474-3	1985	MAO produced aldehydic products which may be found in the incubation medium and may be extracted with the substrate in the chloroform phase by the LIEC method.	Chloroform	123-133	monoamine oxidase A	Rattus norvegicus	0-3
4041237-1	1985	Proteolipid protein (PLP) was isolated from white matter of human brain by chloroform/methanol extraction and further purified by chromatography.	Chloroform	75-85	proteolipid protein 1	Homo sapiens	0-25
6242242-1	1984	The following characteristics are reported for mitochondrial ATPase prepared by the chloroform extraction method: (1) The pH optimum for enzyme activity is at 8.0.	Chloroform	84-94	ATP synthase F1 subunit epsilon	Homo sapiens	47-67
3980412-2	1985	Carr-Price analysis required saponification of the sample with alcoholic potassium hydroxide, extraction with ether, and colorimetry with antimony trichloride in chloroform.	Chloroform	162-172	arrestin 3	Homo sapiens	0-4
6209352-9	1984	The addition of methylamine to plasma pretreated with chloroform in the plasma prekallikrein assay allowed for only a slight increase in the amount of kallikrein measured at 1 minute kaolin activation times, but provided for sustained measurement of activated prekallikrein when kaolin activation times were 5 to 7 minutes.	Chloroform	54-64	kallikrein related peptidase 4	Homo sapiens	82-92
6511912-14	1984	Increases in O2 tension caused a fall in CHCl3 production, which indicated that it decreased CCl3.. GSH had no significant effect on CHCl3 production at any O2 tension.	Chloroform	41-46	C-C motif chemokine ligand 3	Rattus norvegicus	93-97
6093699-1	1984	Ubiquitin was isolated from bovine erythrocytes by a relatively simple procedure involving extraction with chloroform and ethanol, chromatography on DEAE-cellulose, and gel filtration.	Chloroform	107-117	ubiquitin	Bos taurus	0-9
6437407-7	1984	CHCl3 was the least abundant metabolite at low CCl4 doses, but the second most abundant at high doses.	Chloroform	0-5	C-C motif chemokine ligand 4	Rattus norvegicus	47-51
6437407-8	1984	Stronger associations were found between the magnitude of liver injury at 24 hr (quantitated as serum glutamate-pyruvate transaminase activity) and the extent or rate of CCl4 metabolism by pathways leading to CO2 and CHCl3 than by pathways leading to 14C-metabolites bound in liver or excreted in urine.	Chloroform	217-222	C-C motif chemokine ligand 4	Rattus norvegicus	170-174
6740677-3	1984	Metabolism of chloroform (CHCl3) by a cytochrome P-450-dependent process to a reactive metabolite may be required to elicit hepatic and renal toxicities.	Chloroform	14-24	cytochrome P-450	Oryctolagus cuniculus	38-54
6740677-3	1984	Metabolism of chloroform (CHCl3) by a cytochrome P-450-dependent process to a reactive metabolite may be required to elicit hepatic and renal toxicities.	Chloroform	26-31	cytochrome P-450	Oryctolagus cuniculus	38-54
6740677-5	1984	The experiments reported herein were designed to identify the relationship between metabolism and toxicity of CHCl3 in the kidney of rabbits, a species in which renal cytochrome P-450 is induced by phenobarbital.	Chloroform	110-115	cytochrome P-450	Oryctolagus cuniculus	167-183
6740725-0	1984	Effect of chloroform on hepatic and renal DNA synthesis and ornithine decarboxylase activity in mice and rats.	Chloroform	10-20	ornithine decarboxylase, structural 1	Mus musculus	60-83
6719466-3	1984	In vitro studies with male ICR mouse renal cortical slices have indicated that chloroform (CHCl3) is metabolized by the kidney to a nephrotoxic intermediate, possibly by a cytochrome P-450-dependent mechanism similar to that occurring in the liver.	Chloroform	79-89	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	172-188
6719466-3	1984	In vitro studies with male ICR mouse renal cortical slices have indicated that chloroform (CHCl3) is metabolized by the kidney to a nephrotoxic intermediate, possibly by a cytochrome P-450-dependent mechanism similar to that occurring in the liver.	Chloroform	91-96	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	172-188
6719466-4	1984	In this investigation, metabolism of 14CHCl3 by microsomes prepared from renal cortex and liver provided definitive evidence for a role of cytochrome P-450 in the renal metabolism and toxicity of CHCl3.	Chloroform	39-44	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	139-155
6719466-9	1984	These data support the hypothesis that renal cytochrome P-450 metabolizes CHCl3 to a nephrotoxic intermediate.	Chloroform	74-79	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	45-61
6145557-8	1984	Cytochrome P-450 in the microsomal and mitochondrial fraction of the kidney appeared to catalyze the metabolism of CHCl3 to COCl2.	Chloroform	115-120	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-16
6729829-6	1984	The data from this investigation are consistent with the concept that CHCl3 is metabolized by a cytochrome P-450-dependent mechanism in the kidney.	Chloroform	70-75	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	96-112
6420632-4	1984	The products of carboxypeptidase B-like activity on these substrates, 3H-benzoyl-Phe-Ala or 3H-benzoyl Phe-Leu partition quantitatively into chloroform, allowing rapid separation of product from substrate.	Chloroform	141-151	carboxypeptidase B1	Homo sapiens	16-34
6720194-3	1984	On transfer from CCl4 to chloroform, dimethyl sulfoxide, and water, the equilibrium is shifted stepwise towards the imino form, attaining a KT approximately 10 in favour of the imino species in aqueous medium.	Chloroform	25-35	C-C motif chemokine ligand 4	Homo sapiens	17-21
6440512-1	1984	Rate and extent of CCl4 metabolism by pathways leading to CO2 and CHCl3 were evaluated by measuring the amounts of these metabolites exhaled during discrete intervals following six different doses of CCl4.	Chloroform	66-71	C-C motif chemokine ligand 4	Homo sapiens	19-23
6658886-2	1983	1H NMR spectra of all four 17 xi-hydroxy/17 xi-methyl C-3 ketones and all eight C-3 alcohols were recorded in chloroform-d and pyridine-d5.	Chloroform	110-120	complement C3	Homo sapiens	54-57
6726635-7	1984	The hydrazone formation in the system of 2-(4"-hydroxyphenylazo)benzoic acid-triethylamine (1:1) in chloroform was affected only by enthalpy changes, in the same manner as in the system of 2-(4"-hydroxyphenylazo)benzoic acid-bovine serum albumin.	Chloroform	100-110	albumin	Homo sapiens	232-245
6661246-1	1983	The quinone of E-diethylstilbestrol (DES), a postulated metabolic intermediate derived from DES, has been synthesized by oxidation of DES in chloroform using silver oxide.	Chloroform	141-151	desmin	Rattus norvegicus	37-40
6661246-1	1983	The quinone of E-diethylstilbestrol (DES), a postulated metabolic intermediate derived from DES, has been synthesized by oxidation of DES in chloroform using silver oxide.	Chloroform	141-151	desmin	Rattus norvegicus	92-95
6661246-1	1983	The quinone of E-diethylstilbestrol (DES), a postulated metabolic intermediate derived from DES, has been synthesized by oxidation of DES in chloroform using silver oxide.	Chloroform	141-151	desmin	Rattus norvegicus	92-95
6661246-5	1983	DES quinone was stable only in non-protic solvents such as chloroform.	Chloroform	59-69	desmin	Rattus norvegicus	0-3
6671967-1	1983	An alpha-mannosidase was isolated from the extract of acetone powder of CHCl3-treated internal organs of the sea-squirt, Styela plicata.	Chloroform	72-77	alpha-mannosidase	Saccharomyces cerevisiae S288C	3-20
6615546-0	1983	Induction by chloroform of two forms of ornithine decarboxylase in rat liver.	Chloroform	13-23	ornithine decarboxylase 1	Rattus norvegicus	40-63
6615546-3	1983	The activity of both species of ODC was increased at least 20-fold by chloroform treatment of the rats.	Chloroform	70-80	ornithine decarboxylase 1	Rattus norvegicus	32-35
6615546-6	1983	The long-lived species of ODC activity, induced in rat liver by chloroform, has not been reported previously and might be related to the prolonged induction of ODC activity by chloroform and to tumor promotion and growth.	Chloroform	64-74	ornithine decarboxylase 1	Rattus norvegicus	26-29
6615546-6	1983	The long-lived species of ODC activity, induced in rat liver by chloroform, has not been reported previously and might be related to the prolonged induction of ODC activity by chloroform and to tumor promotion and growth.	Chloroform	64-74	ornithine decarboxylase 1	Rattus norvegicus	160-163
6615546-6	1983	The long-lived species of ODC activity, induced in rat liver by chloroform, has not been reported previously and might be related to the prolonged induction of ODC activity by chloroform and to tumor promotion and growth.	Chloroform	176-186	ornithine decarboxylase 1	Rattus norvegicus	26-29
6615546-6	1983	The long-lived species of ODC activity, induced in rat liver by chloroform, has not been reported previously and might be related to the prolonged induction of ODC activity by chloroform and to tumor promotion and growth.	Chloroform	176-186	ornithine decarboxylase 1	Rattus norvegicus	160-163
6857718-3	1983	The ratio CHCl3:CCl4 was lower in the livers of the fasted than in those of the fed mice.	Chloroform	10-15	chemokine (C-C motif) ligand 4	Mus musculus	16-20
6860298-10	1983	Both SOD-1 and SOD-2 were sensitive to CHCl3/EtOH extraction, but this sensitivity was not electromorph specific.	Chloroform	39-44	superoxide dismutase 1, soluble	Mus musculus	5-10
6860298-10	1983	Both SOD-1 and SOD-2 were sensitive to CHCl3/EtOH extraction, but this sensitivity was not electromorph specific.	Chloroform	39-44	superoxide dismutase 2, mitochondrial	Mus musculus	15-20
6678618-8	1983	For example, liver CHCl3 concentrations (as a measure of CCl4 metabolism) correlate strongly with increases in diene conjugation of microsomal lipids (as a measure of CCl4-induced lipid peroxidation); malonaldehyde production appears to be less sensitive as a measure of lipid peroxidation in vivo than diene conjugation.	Chloroform	19-24	C-C motif chemokine ligand 4	Rattus norvegicus	57-61
6678618-8	1983	For example, liver CHCl3 concentrations (as a measure of CCl4 metabolism) correlate strongly with increases in diene conjugation of microsomal lipids (as a measure of CCl4-induced lipid peroxidation); malonaldehyde production appears to be less sensitive as a measure of lipid peroxidation in vivo than diene conjugation.	Chloroform	19-24	C-C motif chemokine ligand 4	Rattus norvegicus	167-171
6658886-2	1983	1H NMR spectra of all four 17 xi-hydroxy/17 xi-methyl C-3 ketones and all eight C-3 alcohols were recorded in chloroform-d and pyridine-d5.	Chloroform	110-120	complement C3	Homo sapiens	80-83
6857699-3	1983	The hepatotoxicity induced by CHCl3 was determined by the serum glutamic-pyruvic transaminase (SGPT), serum glutamic-oxaloacetic transaminase (SGOT) and lactic dehydrogenase (LDH) activities and by the glucose-6-phosphatase (G6Pase) activity of the liver.	Chloroform	30-35	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	202-223
6857699-3	1983	The hepatotoxicity induced by CHCl3 was determined by the serum glutamic-pyruvic transaminase (SGPT), serum glutamic-oxaloacetic transaminase (SGOT) and lactic dehydrogenase (LDH) activities and by the glucose-6-phosphatase (G6Pase) activity of the liver.	Chloroform	30-35	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	225-231
6433926-3	1983	Subsequent treatment of the CRP-lecithin complex with chloroform and sodium citrate buffer enabled extraction of the CRP in the buffer layer.	Chloroform	54-64	C-reactive protein	Homo sapiens	28-31
6295746-1	1983	We report here partial isolation and characterization of at least two GnRH-receptor binding factors from the ethanol: chloroform: acetic acid (ECA) extracts of rat testis.	Chloroform	118-128	gonadotropin releasing hormone receptor	Rattus norvegicus	70-83
6433926-3	1983	Subsequent treatment of the CRP-lecithin complex with chloroform and sodium citrate buffer enabled extraction of the CRP in the buffer layer.	Chloroform	54-64	C-reactive protein	Homo sapiens	117-120
7151757-0	1982	Chloroform induction of ornithine decarboxylase activity in rats.	Chloroform	0-10	ornithine decarboxylase 1	Rattus norvegicus	24-47
6826281-2	1983	The conformations of chlamydocin and cyclo (Ala-Aib-Phe-D-Pro) (Ala4-chlamydocin) in chloroform have been investigated by nuclear magnetic resonance, infrared and circular dichroism spectroscopy.	Chloroform	85-95	ANIB1	Homo sapiens	48-51
6408356-1	1983	Isolates of Mycoplasma pneumoniae and M. salivarium could be subclassified at the strain level by inhibitors (ch-Mcin) derived from mycoplasmal cells treated with chloroform.	Chloroform	163-173	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	113-117
7151757-3	1982	Since induction of ornithine decarboxylase (ODC) activity has been proposed as a molecular marker for tumor promoters, we have investigated the effect of chloroform on ODC activity in rats.	Chloroform	154-164	ornithine decarboxylase 1	Rattus norvegicus	168-171
7151757-4	1982	Chloroform induced a dose-dependent increase of hepatic ODC with an apparent threshold at 100 mg/kg body weight.	Chloroform	0-10	ornithine decarboxylase 1	Rattus norvegicus	56-59
7151757-9	1982	The induction by chloroform of hepatic ODC activity might be associated with regenerative hyperplasia while the renal carcinogenicity of chloroform could not be demonstrated to be associated with ODC induction.	Chloroform	17-27	ornithine decarboxylase 1	Rattus norvegicus	39-42
6291543-1	1982	Diethyldithiocarbamate (DTC) and carbon disulfide (CS2), at nearly equimolar oral dose levels, protected mice against liver damage induced by carbon tetrachloride, chloroform, bromotrichloromethane, thioacetamide, bromobenzene, furosemide, acetaminophen, dimethylnitrosamine and trichloroethylene, as evidenced by the suppression of elevations in plasma GPT activity and liver calcium content, and of histopathological alterations.	Chloroform	164-174	calsyntenin 2	Mus musculus	51-54
6215060-1	1982	Periodate-oxidized ATP (o-ATP) was prepared as an affinity label of nucleotide binding sites on the chloroform-released ox heart mitochondrial ATPase.	Chloroform	100-110	dynein axonemal heavy chain 8	Homo sapiens	143-149
6180371-1	1982	Treatment of normal plasma with chloroform and ellagic acid yielded esterase activity against tosylarginine methyl ester, which reached a maximum within 2 h. After 2 h most or all of the activity as resistant to inhibition by soybean trypsin inhibitor (STI), but was still sensitive to the low molecular weight inhibitors di-isopropyl fluorophosphate, aprotinin and prolyl-phenylalanyl-arginyl chloromethane.	Chloroform	32-42	kunitz trypsin protease inhibitor	Glycine max	234-251
7132572-3	1982	ISOP pretreatment, which markedly enhanced the hepatotoxicity of CCl4, selectively enhanced the rate and total extent of 14CO2 and CHCl3 metabolite exhalation.	Chloroform	131-136	C-C motif chemokine ligand 4	Rattus norvegicus	65-69
7132572-4	1982	The pathways of CCl4 metabolism leading to CO2 and CHCl3 metabolite formation may be more relevant to the hepatotoxicity of CCl4 than the pathways leading to urinary, fecal or covalently bound metabolites.	Chloroform	51-56	C-C motif chemokine ligand 4	Rattus norvegicus	16-20
7132572-4	1982	The pathways of CCl4 metabolism leading to CO2 and CHCl3 metabolite formation may be more relevant to the hepatotoxicity of CCl4 than the pathways leading to urinary, fecal or covalently bound metabolites.	Chloroform	51-56	C-C motif chemokine ligand 4	Rattus norvegicus	124-128
6803857-4	1982	Plasma treated with chloroform to destroy inhibitors of kallikrein was activated with dilute kaolin (final concentration 1 mg/ml) for 1 min at 25 degrees C. Activated plasma prekallikrein had 78% (1.92 mumole/min/ml) of activity of purified kallikrein at plasma concentration.	Chloroform	20-30	kallikrein related peptidase 4	Homo sapiens	177-187
6282362-8	1982	Thin-layer chromatography analysis of chloroform-methanol extracts showed substances that comigrated with authentic 5-hydroxyeicosatetraenoic acid had a marked increase in radioactivity following PAF stimulation at 10(-7) M. PAF failed to stimulate release of granule enzymes, B-glucuronidase, lysozyme, or myeloperoxidase unless cytochalasin-B were added.	Chloroform	38-48	PCNA clamp associated factor	Homo sapiens	196-199
6282362-8	1982	Thin-layer chromatography analysis of chloroform-methanol extracts showed substances that comigrated with authentic 5-hydroxyeicosatetraenoic acid had a marked increase in radioactivity following PAF stimulation at 10(-7) M. PAF failed to stimulate release of granule enzymes, B-glucuronidase, lysozyme, or myeloperoxidase unless cytochalasin-B were added.	Chloroform	38-48	PCNA clamp associated factor	Homo sapiens	225-228
6282362-8	1982	Thin-layer chromatography analysis of chloroform-methanol extracts showed substances that comigrated with authentic 5-hydroxyeicosatetraenoic acid had a marked increase in radioactivity following PAF stimulation at 10(-7) M. PAF failed to stimulate release of granule enzymes, B-glucuronidase, lysozyme, or myeloperoxidase unless cytochalasin-B were added.	Chloroform	38-48	myeloperoxidase	Homo sapiens	277-322
6175874-1	1982	Two preparations of myelin basic protein (MBP) were derived from an acid excretion of chloroform-methanol defatted bovine spinal cord.	Chloroform	86-96	myelin basic protein	Bos taurus	20-40
7090007-2	1982	In rats fed a standard laboratory diet, treatment with PB prior to injection of CCl4 increased expiration of both CHCl3 and pentane.	Chloroform	114-119	C-C motif chemokine ligand 4	Rattus norvegicus	80-84
6175874-1	1982	Two preparations of myelin basic protein (MBP) were derived from an acid excretion of chloroform-methanol defatted bovine spinal cord.	Chloroform	86-96	myelin basic protein	Bos taurus	42-45
6171566-5	1981	Partially purified PGF-A was soluble in 80% ethanol and insoluble in chloroform or ethyl acetate.	Chloroform	69-79	placental growth factor	Homo sapiens	19-22
7098497-5	1982	After addition of beta-glucuronidase to the aqueous phase, about 90% of the radioactivity could be extracted into chloroform, demonstrating the DES-glucuronic acid is the primary metabolite.	Chloroform	114-124	glucuronidase, beta	Rattus norvegicus	18-36
7066349-3	1982	However, the stabilizing effect on lipoprotein lipase was reduced by 60-70% by the extraction of cells with chloroform/methanol (2:1).	Chloroform	108-118	lipoprotein lipase	Bos taurus	35-53
7036531-4	1982	Antibodies within the Ss blood group system were easily eluted using chloroform but not using ether.	Chloroform	69-79	glycophorin B (MNS blood group)	Homo sapiens	22-36
7036531-5	1982	Also, the chloroform method yielded informative eluates when prepared from red cells of patients with warm antibody autoimmune hemolytic anemia, drug-induced immune hemolytic anemia, hemolytic disease of the newborn caused by ABO or Rh fetal maternal incompatibility, or from patients having a positive direct antiglobulin test as a result of alloantibodies stimulated by recent transfusion ("delayed transfusion reaction").	Chloroform	10-20	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	226-229
7302959-3	1981	Multiple injections of CCl4 decreased both the metabolism of CCl4 to CHCl3 and the level of in vivo lipid peroxidation following administration of a subsequent dose of CCl4.	Chloroform	69-74	C-C motif chemokine ligand 4	Rattus norvegicus	23-27
7302959-3	1981	Multiple injections of CCl4 decreased both the metabolism of CCl4 to CHCl3 and the level of in vivo lipid peroxidation following administration of a subsequent dose of CCl4.	Chloroform	69-74	C-C motif chemokine ligand 4	Rattus norvegicus	61-65
7302959-3	1981	Multiple injections of CCl4 decreased both the metabolism of CCl4 to CHCl3 and the level of in vivo lipid peroxidation following administration of a subsequent dose of CCl4.	Chloroform	69-74	C-C motif chemokine ligand 4	Rattus norvegicus	61-65
7004725-7	1980	The renin binding substance of the dog was unstable to heat and low pH, but vitally resistant to Triton X-100 and chloroform.	Chloroform	114-124	renin	Canis lupus familiaris	4-9
6169709-1	1981	Cytochrome P-450 mRNA has been partially purified from membrane-bound polysomes of the livers of phenobarbital-treated rats by SDS-phenol-chloroform extraction, followed by poly(U)-Sepharose chromatography and by centrifugation through a sucrose density gradient.	Chloroform	138-148	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
7255876-0	1981	Effects of differential changes in rat hepatic and renal cytochrome P-450 concentrations on hepatotoxicity and nephrotoxicity of chloroform.	Chloroform	129-139	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	57-73
7378472-2	1980	The 15N-NMR data obtained in chloroform and methanol are reported for Boc-L-Val1-L-Pro2-Gly3-Gly4-OMe, a repeat tetrapeptide sequence of tropoelastin.	Chloroform	29-39	elastin	Homo sapiens	137-149
6449333-8	1980	All sera from liver disease patients contain the antibody directed against a mercurial-sensitive protein found in the chloroform-released ATPase preparation, and, in addition, varying titres of antibodies against two or more mercurial-resistant membrane components, of which at least one is on the inner membrane and one on the outer membrane.	Chloroform	118-128	dynein axonemal heavy chain 8	Homo sapiens	138-144
6259312-9	1980	These results suggest that lipid peroxidation hypothesis proposed for CCl4 hepatotoxicity may be applied to the case of CHCl3 though there exist some qualitatively different characteristics between these hepatotoxins, and that the mechanisms of the loss of microsomal G-6-Pase and cytochrome P-450 by either of these hepatotoxins might be different.	Chloroform	120-125	C-C motif chemokine ligand 4	Rattus norvegicus	70-74
160228-0	1979	MgATP-induced inhibition of the enzymic activity of chloroform-released ox-heart mitochondrial ATPase.	Chloroform	52-62	ATP synthase F1 subunit epsilon	Homo sapiens	81-101
549628-6	1979	Conditions which abolished the break enabled endogenous cardiolipin to be removed from the enzyme by chloroform/methanol extraction Cardiolipin from acetylcholinesterase incubated in high salt in Ca2+ -chelating conditions was not accessible to digestion by phospholipase A2, and was not separated from the enzyme by flotation in a sucrose density gradient or by Sephadex G-200 chromatography.	Chloroform	101-111	acetylcholinesterase	Bos taurus	149-169
156841-0	1979	Preparation of the soluble ATPase from mitochondria, chloroplasts, and bacteria by the chloroform technique.	Chloroform	87-97	dynein axonemal heavy chain 8	Homo sapiens	27-33
429090-6	1979	Oxytocin elutes with 33% MeOH-CHCl3.	Chloroform	30-35	oxytocin/neurophysin I prepropeptide	Homo sapiens	0-8
211261-4	1978	RNA prepared by phenol-chloroform extraction of mouse tissues, including embryos and livers of weanling mice, transferred Fv-1 locus-specific resistance into DEAE-dextran-treated SC-1 cells.	Chloroform	23-33	Friend virus susceptibility 1	Mus musculus	122-126
27728-6	1978	At higher pH values (5.5) SP could be transferred from an aqueous phase into an organic phase (chloroform:methanol, 2:1) and recombined with TLE (which was previously freed from endogenous SP) contained in this phase.	Chloroform	95-105	tachykinin precursor 1	Homo sapiens	26-28
751362-1	1978	A rapid and simole procedure for isolation of ceruloplasmin from porcine and bovine blood sera was elaborated; it involves DEAE-Sephadex A-50 chromatography, precipitation with an ethanol-chloroform mixture plus extraction with saline, and preparative polyacrylamide-gel electrophoresis.	Chloroform	188-198	ceruloplasmin and hephaestin like 1	Bos taurus	46-59
893311-3	1977	HC1, based on solvent extraction into chloroform of the complex formed with bromocresol green.	Chloroform	38-48	CYCS pseudogene 39	Homo sapiens	0-3
144099-8	1977	Pretreatment  of  frozen cryostat sections with a mixture of equal parts of chloroform and acetone give a good fixation of the plasma membrane enzymes 5"-nucleotidase, ATP-ase, alkaline phosphate and leucyl-beta-naphthylamidase.	Chloroform	76-86	5'-nucleotidase ecto	Homo sapiens	151-166
144099-8	1977	Pretreatment  of  frozen cryostat sections with a mixture of equal parts of chloroform and acetone give a good fixation of the plasma membrane enzymes 5"-nucleotidase, ATP-ase, alkaline phosphate and leucyl-beta-naphthylamidase.	Chloroform	76-86	dynein axonemal heavy chain 8	Homo sapiens	168-175
891779-2	1977	2 peaks of proteolipids eluted in chloroform-methanol 4/1 showed the binding capacity for C14 - 5-HT.	Chloroform	34-44	anti-Mullerian hormone receptor type 2	Rattus norvegicus	90-93
880222-1	1977	Treatment of the chloroform/methanol-insoluble residue of rat brain myelin with lithium 3,5-di-iodosalicylate solubilized the major myelin-associated glycoprotein along with most other proteins and glycoproteins.	Chloroform	17-27	myelin-associated glycoprotein	Rattus norvegicus	132-162
984122-5	1976	Results confirm that chloroform extraction yields more accurate clinical information in regard to Rh isoimmunized patients in whom a "bloody tap" is obtained.	Chloroform	21-31	nuclear RNA export factor 1	Homo sapiens	141-145
135588-5	1976	Bio-Gel A 0.5 m fractionation of CHCl3-extracted, PLG-depleted plasma reveals fractions with the following activities: (1) streptokinase-activatable, PLG-independent fibrinolytic activities; (2) PLG activator activities; and (3) plasmin-stimulated but PLG-independent fibrinolytic activities, which include activities inhibited by hexadimethrine bromide and which cofractionate in part with plasmin-stimulated procoagulant activities.	Chloroform	33-38	plasminogen	Homo sapiens	150-153
135588-5	1976	Bio-Gel A 0.5 m fractionation of CHCl3-extracted, PLG-depleted plasma reveals fractions with the following activities: (1) streptokinase-activatable, PLG-independent fibrinolytic activities; (2) PLG activator activities; and (3) plasmin-stimulated but PLG-independent fibrinolytic activities, which include activities inhibited by hexadimethrine bromide and which cofractionate in part with plasmin-stimulated procoagulant activities.	Chloroform	33-38	plasminogen	Homo sapiens	150-153
135588-5	1976	Bio-Gel A 0.5 m fractionation of CHCl3-extracted, PLG-depleted plasma reveals fractions with the following activities: (1) streptokinase-activatable, PLG-independent fibrinolytic activities; (2) PLG activator activities; and (3) plasmin-stimulated but PLG-independent fibrinolytic activities, which include activities inhibited by hexadimethrine bromide and which cofractionate in part with plasmin-stimulated procoagulant activities.	Chloroform	33-38	plasminogen	Homo sapiens	150-153
1254583-5	1976	After treatment of the rhodopsin with chloroform/methanol (2/1) to remove lipids and detergents, the carbohydrate content was measured by gas-liquid chromatography, colorimetric and enzymatic analyses, paper chromatography, and electrophoresis.	Chloroform	38-48	rhodopsin	Bos taurus	23-32
135588-7	1976	The findings indicate that the enhanced fibrinolytic activity resulting from CHCl3 treatment is independent of plasmin as the ultimate fibrinolytic enzyme, although activities stimulated by plasmin may contribute, and that such treatment is a useful maneuver for study of PLG-dependent and PLG-independent fibrinolytic mechanisms, and their interactions.	Chloroform	77-82	plasminogen	Homo sapiens	272-275
135588-7	1976	The findings indicate that the enhanced fibrinolytic activity resulting from CHCl3 treatment is independent of plasmin as the ultimate fibrinolytic enzyme, although activities stimulated by plasmin may contribute, and that such treatment is a useful maneuver for study of PLG-dependent and PLG-independent fibrinolytic mechanisms, and their interactions.	Chloroform	77-82	plasminogen	Homo sapiens	290-293
965337-2	1976	Similar blue colors were obtained using SbCl3, CF3COOH, and CCl3COOH in solutions of CHCl3, CH2Cl2 and C2H4Cl2.	Chloroform	85-90	C-C motif chemokine ligand 3	Homo sapiens	60-64
8823-4	1976	Addition of DPL in chloroform to distilled water before dispersion by sonication did not prevent the effect of the humidity.	Chloroform	19-29	prion like protein doppel	Homo sapiens	12-15
8823-5	1976	However, when the chloroform solution of DPL was added to 0.15 M NaCl before sonication, the adsorbed film produced immediately a stable gamma min of zero in a saturated atmosphere, 37 degrees C. In the absence of chloroform, with DPL adsorbed from either distilled water or 0.15 M NaCl, the effect of humidity was reversed either by removing the chamber and returning the wet film to room air or by introducing small quantities of dispersing agents such as cholesteryl palmitate.	Chloroform	18-28	prion like protein doppel	Homo sapiens	41-44
8823-5	1976	However, when the chloroform solution of DPL was added to 0.15 M NaCl before sonication, the adsorbed film produced immediately a stable gamma min of zero in a saturated atmosphere, 37 degrees C. In the absence of chloroform, with DPL adsorbed from either distilled water or 0.15 M NaCl, the effect of humidity was reversed either by removing the chamber and returning the wet film to room air or by introducing small quantities of dispersing agents such as cholesteryl palmitate.	Chloroform	18-28	prion like protein doppel	Homo sapiens	231-234
8823-5	1976	However, when the chloroform solution of DPL was added to 0.15 M NaCl before sonication, the adsorbed film produced immediately a stable gamma min of zero in a saturated atmosphere, 37 degrees C. In the absence of chloroform, with DPL adsorbed from either distilled water or 0.15 M NaCl, the effect of humidity was reversed either by removing the chamber and returning the wet film to room air or by introducing small quantities of dispersing agents such as cholesteryl palmitate.	Chloroform	214-224	prion like protein doppel	Homo sapiens	41-44
982615-3	1976	With an increase in R from the ethyl to butyl one the ability to the  additional inhibition of the brain own cholinesterase lowers due to incubation of homogenate at 37 degrees C, that evidences for an essential drop in the studied series of the free OPI fraction relative to the free OPI extracted by chloroform.	Chloroform	302-312	butyrylcholinesterase	Rattus norvegicus	109-123
7791-2	1976	In the repeated chloroform stress variant the first impulse determines the amplitude of TAT induction; the second stress can only produce superinduction if repeated 40 minutes after the onset of the first one.	Chloroform	16-26	tyrosine aminotransferase	Mus musculus	88-91
241644-8	1975	Components of the membrane fraction of rat liver mitochondria labeled in vitro displayed an unequal solubility in acidic (2 mM HC1) chloroform/methanol (2/1) mixture; as detected by sodium dodecylsulfate-polyacrylamide gel electrophoresis a single labeled component with apparent molecular weight of 10 000 was soluble in neutral chloroform/methanol.	Chloroform	132-142	Hypercalciuria QTL 1	Rattus norvegicus	127-130
54896-8	1976	Quantitation of arginine esterase activity in plasma treated with cloroform and ellagic acid indicated that both the total arginine esterase activity and that fraction of arginine esterase activity inhibited by soybean trypsin inhibitor (SBTI) were decreased in most CF homozygote and obligate heterozygote plasma samples relative to normal control values.	Chloroform	66-75	kunitz trypsin protease inhibitor	Glycine max	219-236
1147200-10	1975	CCl4 occupies a middle position between chloroform and halothane.	Chloroform	40-50	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
1120154-8	1975	The specific activities for the Ss blood group antigens were increased 3-10-fold by purificantion of GP-III from the aqueous phase of chloroform methanol extracts.	Chloroform	134-144	glycophorin B (MNS blood group)	Homo sapiens	32-46
18961635-1	1975	A rapid method of simultaneous spectrophotometric determination of up to 4 ppm of iron(II) and 20 ppm of copper(II) in a mixture by chloroform extraction of the syn-phenyl-alpha-pyridyl ketoxime complexes at pH 10.0, is developed.	Chloroform	132-142	synemin	Homo sapiens	161-164
4265360-0	1973	Myosin conformation and enzymatic activity: effect of chloroform, diethyl ether and halothane on optical rotatory dispersion and APTase.	Chloroform	54-64	myosin heavy chain 14	Homo sapiens	0-6
10793760-3	1974	The 5"-[unk]-acetyl derivative of [unk] has also been found to adopt the intramolecularly stacked conformation in dimethylsulphoxide, but a non-stacked one in chloroform.	Chloroform	159-169	unk zinc finger	Homo sapiens	8-11
10793760-3	1974	The 5"-[unk]-acetyl derivative of [unk] has also been found to adopt the intramolecularly stacked conformation in dimethylsulphoxide, but a non-stacked one in chloroform.	Chloroform	159-169	unk zinc finger	Homo sapiens	35-38
4404917-0	1972	[Formation of chloroform from carbon tetrachloride in liver microsomes, lipid peroxidation and destruction of cytochrome P-450].	Chloroform	14-24	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	110-127
5158903-2	1971	A simple two-phase chloroform-aqueous buffer system was used to investigate the interaction of insulin with phospholipids and other amphipathic substances.	Chloroform	19-29	insulin	Homo sapiens	95-102
18960936-1	1971	The colorimetric determination of cobalt with nitroso-R salt (NRS) has been modified and improved by the introduction of extraction of the Co-NRS chelate into a chloroform solution of trioctylmethylammonium chloride.	Chloroform	161-171	sphingolipid transporter 1 (putative)	Homo sapiens	46-60
5158903-9	1971	The two-phase system was adapted to act as a simple functional system with which to investigate possible effects of insulin on the structural and functional properties of phospholipid micelles in chloroform, by using the distribution of [(14)C]glucose between the two phases as a monitor of phospholipid-insulin interactions.	Chloroform	196-206	insulin	Homo sapiens	116-123
5158903-13	1971	The significance of these results and the molecular requirements for the formation of insulin-phospholipid complexes in chloroform are discussed.	Chloroform	120-130	insulin	Homo sapiens	86-93
18960936-1	1971	The colorimetric determination of cobalt with nitroso-R salt (NRS) has been modified and improved by the introduction of extraction of the Co-NRS chelate into a chloroform solution of trioctylmethylammonium chloride.	Chloroform	161-171	sphingolipid transporter 1 (putative)	Homo sapiens	62-65
18960936-1	1971	The colorimetric determination of cobalt with nitroso-R salt (NRS) has been modified and improved by the introduction of extraction of the Co-NRS chelate into a chloroform solution of trioctylmethylammonium chloride.	Chloroform	161-171	sphingolipid transporter 1 (putative)	Homo sapiens	142-145
4994906-1	1971	Absorbance at 260 nm due to Nonidet P40 in cytoplasmic extracts can effectively be reduced by extraction with CHCl(3) without appreciable loss of ribonucleic acid.	Chloroform	110-117	interleukin 9	Homo sapiens	36-39
4241814-6	1969	Evidence is presented that an additional component may be needed for the generation of fibrinolytic activity in mixtures containing Hageman factor, HF-cofactor, and plasminogen.The long-recognized generation of plasmin activity in chloroform-treated euglobulin fractions of plasma was found to be dependent upon the presence of Hageman factor.	Chloroform	231-241	coagulation factor XII	Homo sapiens	328-342
4338362-0	1971	In vivo effects of carbon tetrachloride and chloroform on liver and kidney glucose-6-phosphatase in mice.	Chloroform	44-54	glucose-6-phosphatase, catalytic	Mus musculus	75-96
13884381-0	1962	[On the hydrolysis of urinary corticosteroids with beta-glucuronidase in the presence of chloroform.	Chloroform	89-99	glucuronidase beta	Homo sapiens	51-69
18959902-2	1966	The matrix materials are separated from the manganese by extraction as cupferrates, after sample dissolution, then the red complex formed between manganese(II) and 1-(2-pyridylazo)-2-naphthol, PAN, is extracted into chloroform from an ammoniacal tartrate-cyanide medium.	Chloroform	216-226	adenosine deaminase 2	Homo sapiens	193-196
13658958-1	1959	Dichloromethane and chloroform have been found to inhibit the action of liver beta-glucuronidase on phenolphthalein glucuronic acid at concentrations which produce a considerable enhancement of bacterial beta-glucuronidase.	Chloroform	20-30	glucuronidase beta	Homo sapiens	78-96
13887179-1	1962	The proteolytic activity in chloroform-treated plasma euglobulins has been attributed to plasmin.	Chloroform	28-38	plasminogen	Homo sapiens	89-96
13887179-3	1962	Epsilon aminocaproic acid, which inhibits the activation of plasminogen, the precursor of plasmin, by streptokinase, urokinase, and tissue activators enhanced the development of casein hydrolytic activity in a mixture of chloroform and plasma euglobulins.	Chloroform	221-231	plasminogen	Homo sapiens	60-67
14440415-1	1960	The potentiating action of chloroform on bacterial beta-glucuronidase has been shown to increase as the interface area between the two liquid phases increases.	Chloroform	27-37	glucuronidase beta	Homo sapiens	51-69
13658958-1	1959	Dichloromethane and chloroform have been found to inhibit the action of liver beta-glucuronidase on phenolphthalein glucuronic acid at concentrations which produce a considerable enhancement of bacterial beta-glucuronidase.	Chloroform	20-30	glucuronidase beta	Homo sapiens	204-222
13105661-0	1953	Fibrinolysins of human plasma; a comparison of fibrinolytic plasma from normal subjects and from cadaver blood with plasmin prepared by activation with chloroform.	Chloroform	152-162	plasminogen	Homo sapiens	116-123
13084846-1	1953	Ca(++) potentiates the inactivation of human complement by streptokinase-activated plasmin and chloroform-activated bovine plasmin.	Chloroform	95-105	plasminogen	Bos taurus	123-130
13052820-4	1953	Chloroform-activated human plasmin and bovine plasmin also destroy these components of complement, but are less effective than the streptokinase-activated enzyme.	Chloroform	0-10	plasminogen	Homo sapiens	27-34
14791274-0	1950	[Chloroform anesthesia as an aid in the examination and treatment of the penis and prepuce of the bull].	Chloroform	1-11	activation induced cytidine deaminase	Homo sapiens	29-32
20274541-0	1946	The effect of chloroform and ether on the activity of cholinesterase.	Chloroform	14-24	butyrylcholinesterase	Homo sapiens	54-68
19870699-1	1937	The bleeding tendency in acute chloroform intoxication is due to deficiency in both plasma fibrinogen and plasma prothrombin.	Chloroform	31-41	fibrinogen beta chain	Homo sapiens	91-101
19870699-1	1937	The bleeding tendency in acute chloroform intoxication is due to deficiency in both plasma fibrinogen and plasma prothrombin.	Chloroform	31-41	coagulation factor II, thrombin	Homo sapiens	113-124
34040519-9	2021	In alpha-glucosidase inhibitory activity, maximum inhibition was observed in DCM and chloroform extracts of SBGC (>85% inhibition at 25% concentration), followed by KBGC (>80% inhibition at 25% concentration), JBGC and GC.	Chloroform	85-95	sucrase isomaltase (alpha-glucosidase)	Mus musculus	3-20
19873463-2	1946	The lipids released by the action of light on rhodopsin and iodopsin are found to be similar and to possess a labile absorption spectrum in chloroform, with a rising peak at about 390 mmicro and a declining peak in the region of 470 mmicro.	Chloroform	140-150	rhodopsin	Homo sapiens	46-55
32638314-4	2021	This is due to the generation of photo-active reactive oxygen species (HO  and HO2 -/O2 -) under photolysis in STP effluent, as verified by experiments in the presence of 2-propanol and chloroform.	Chloroform	186-196	heme oxygenase 2	Homo sapiens	79-82
33968577-3	2021	Therefore, in the present study, chloroform bioactive fraction of P. santalinus (CFP) was isolated and evaluated for its activity against adipogenesis and adipogenesis-induced inflammation in 3T3-L1 cell culture model.	Chloroform	33-43	complement factor properdin	Mus musculus	81-84
33823106-4	2021	It was observed that the remaining aqueous fraction has higher total phenolic content while higher activity in the CUPRAC and FRAP assays was displayed for the methanolic extract and chloroform fraction.	Chloroform	183-193	mechanistic target of rapamycin kinase	Homo sapiens	126-130
3966926-0	1985	Chloroform-induced alteration of glutathione S-transferase activity.	Chloroform	0-10	hematopoietic prostaglandin D synthase	Rattus norvegicus	33-58
3966926-5	1985	Twenty-four hours after chloroform treatment, glutathione S-transferases A and C were clearly detectable as was D + E and a small amount of B. Hepatic cytosolic glutathione S-transferase activity was decreased by chloroform treatment, and reached a minimum at 5 hr after treatment.	Chloroform	24-34	hematopoietic prostaglandin D synthase	Rattus norvegicus	46-71
3966926-5	1985	Twenty-four hours after chloroform treatment, glutathione S-transferases A and C were clearly detectable as was D + E and a small amount of B. Hepatic cytosolic glutathione S-transferase activity was decreased by chloroform treatment, and reached a minimum at 5 hr after treatment.	Chloroform	213-223	hematopoietic prostaglandin D synthase	Rattus norvegicus	46-71
3966926-6	1985	Corresponding to the decrease of hepatic cytosol glutathione S-transferase activity, serum glutathione S-transferase activity was elevated maximally 5 hr after chloroform treatment and returned to almost normal by 24 hr.	Chloroform	160-170	hematopoietic prostaglandin D synthase	Rattus norvegicus	49-74
3966926-6	1985	Corresponding to the decrease of hepatic cytosol glutathione S-transferase activity, serum glutathione S-transferase activity was elevated maximally 5 hr after chloroform treatment and returned to almost normal by 24 hr.	Chloroform	160-170	hematopoietic prostaglandin D synthase	Rattus norvegicus	91-116
3966926-7	1985	Treatment of rats with SKF 525-A or cysteine inhibited the chloroform-induced elevation of serum glutathione S-transferase activity.	Chloroform	59-69	hematopoietic prostaglandin D synthase	Rattus norvegicus	97-122
3966926-8	1985	The chromatographic properties of the glutathione S-transferases present in serum were similar to glutathione S-transferase D + E. Furthermore, after incubation of partially purified cytosolic glutathione S-transferases with chloroform in the presence of hepatic microsomes and NADPH, only transferase D + E was detected.	Chloroform	225-235	hematopoietic prostaglandin D synthase	Rattus norvegicus	38-63
3966926-9	1985	The addition of bilirubin to partially purified cytosolic glutathione S-transferase decreased the basic character of glutathione S-transferases B and C. In conclusion, chloroform caused a release of hepatic cytosolic glutathione S-transferases into serum.	Chloroform	168-178	hematopoietic prostaglandin D synthase	Rattus norvegicus	58-83
33933799-4	2021	This study focuses on the local structures of Br- in hexadecyltrimethylammonium bromide (HTAB) RMs formed in chloroform and 10% hexanol/heptane.	Chloroform	109-119	chromosome 12 open reading frame 73	Homo sapiens	46-48
33428425-7	2021	Using these parameters, IS-SPA accounts for asymmetry of charge solvation and reproduces the explicit solvent potential of mean force of dimerization of two oppositely charged Lennard-Jones spheres in chloroform with high fidelity.	Chloroform	201-211	surfactant protein A1	Homo sapiens	27-30
33855299-2	2021	We reported earlier a high acetylcholinesterase inhibitory and antioxidant activity in the chloroform fraction of this plant.	Chloroform	91-101	acetylcholinesterase (Cartwright blood group)	Homo sapiens	27-47
33855299-3	2021	Therefore, this study was designed to explore the compounds with acetylcholinesterase inhibitory and antioxidant activities from the chloroform fraction of Vanda roxburghii.	Chloroform	133-143	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-85
33338791-7	2021	Anthropogenic CCl4 was found with an average concentration of 44.9 pmol/L, and there was a strong positive relationship between CCl4 and CHCl3 in the upper water, indicating their similar source of pollutant transport caused by anthropogenic activities.	Chloroform	137-142	C-C motif chemokine ligand 4	Homo sapiens	128-132
33797536-6	2021	The chloroform fraction of P. undulata was the most potent, exhibiting an EC50 of 1.4 mug mL-1 and SI value of 12.1.	Chloroform	4-14	L1 cell adhesion molecule	Mus musculus	90-94
33540490-3	2021	However, for the hexameric Ac-(deltaAc5 a)6 -NHMe, the mixed H16/14 helical structure was found to be most preferred in chloroform (populated at 68 %), whereas the H14 helical structure was the most dominant conformation in water (populated at 60 %).	Chloroform	120-130	H1.6 linker histone, cluster member	Homo sapiens	61-64
33478055-7	2021	These results suggest that the chloroform- and hexane-soluble fraction mediated the mitogen-activated protein kinase (MAPK) inhibition, in particular the JNK pathway, thereby lowering the inflammatory cascades in LPS-activated murine microglia.	Chloroform	31-41	mitogen-activated protein kinase 8	Mus musculus	154-157
31145050-8	2021	CCl4 (10 mg/L) was almost completely dechlorinated within 60 min and the predominant intermediate products were CHCl3, C2Cl4 and C2HCl3.	Chloroform	112-117	C-C motif chemokine ligand 4	Homo sapiens	0-4
33297068-9	2021	Its regulation by antioxidative defense enzymes activities can be attributed to observed decline in these enzymes (catalase, ascorbate peroxidase, guaiacol peroxidase) activities with increasing concentration again where TCAA found more significantly affected than TBM and TCM over control.	Chloroform	273-276	catalase	Vigna radiata	115-123
32648128-5	2020	RESULTS: T and CHOL concentrations along with 3beta-HSD activity were significantly higher in the animals treated with the low dose than in those treated with the high dose of the chloroform extract (P<0.05).	Chloroform	180-190	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	46-55
32648128-9	2020	Only the high dose of chloroform extract had significant inhibitory effects on MPO activity (P<0.05).	Chloroform	22-32	myeloperoxidase	Rattus norvegicus	79-82
33306055-0	2020	In Silico Molecular Docking Analysis of Potential Anti-Alzheimer"s Compounds Present in Chloroform Extract of Carissa carandas Leaf Using Gas Chromatography MS/MS.	Chloroform	88-98	gastrin	Homo sapiens	138-141
33306055-7	2020	The chloroform extract was subjected to gas chromatography-MS/MS analysis, and the observed chromatogram revealed the presence of 48 chemical constituents.	Chloroform	4-14	gastrin	Homo sapiens	40-43
33306055-11	2020	Conclusions: The chloroform leaf extract of C carandas was found to contain constituents that have affinities for the 2 targets tested; that is, amyloid beta and acetylcholinesterase.	Chloroform	17-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	162-182
33867327-4	2020	The animal study was conducted on mice treated with CCl4 using methanolic and chloroform extracts (100, 200 and 300mg/kg b.w), with silymarin as a positive control.	Chloroform	78-88	chemokine (C-C motif) ligand 4	Mus musculus	52-56
32984682-4	2020	The syn-form of 3 was obtained by the recrystallization from toluene and CHCl3.	Chloroform	73-78	synemin	Homo sapiens	4-7
32562503-1	2020	We report the catalytic activity for the complexes - cis-[RuCl2 (dppb)(bipy)] (A), and [eta6 -(p-cymene)Ru (dppb)Cl]PF6 (B), wherein dppb = 1,4-bis (diphenylphosphine)butane, and bipy = 2,2"-bipyridine - for the synthesis of CDCl3 from CHCl3 using D2 O as deuterium source.	Chloroform	236-241	sperm associated antigen 17	Homo sapiens	116-119
33138135-6	2020	NCI-H929 displayed pronounced sensitivity towards T. vulgaris (TCF) and A. lappa (ACF) chloroform fractions with IC50 values of 6.49 +- 1.48 and 21.9 +- 0.69 mug/mL, respectively.	Chloroform	87-97	ACF	Homo sapiens	82-85
33025115-5	2020	Based on ESP maps, doping of Cr, Ti, Fe, and Ni is the cause of strong electrophilic region creation which is very useful for adsorption process CH2Cl2 and CHCl3 on nanocages.	Chloroform	156-161	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	9-12
32994707-8	2020	Also, the hepatoprotective chloroform fraction mildly activated CYP3A4 in HepG2 cells (dual-luciferase assay).	Chloroform	27-37	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	64-70
33583801-4	2020	The animal study was conducted on mice treated with CCl4 using methanolic and chloroform extracts (100, 200 and 300 mg/kg b.w), with silymarin as a positive control.	Chloroform	78-88	chemokine (C-C motif) ligand 4	Mus musculus	52-56
32867254-5	2020	To address this drawback, chloroform at a concentration of more than 2% (v/v) was found to remove NSP efficiently without damaging the FMDV particles.	Chloroform	26-36	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	98-101
32639731-0	2020	Solvation Thermodynamics in Different Solvents - Water-Chloroform Partition Coefficients from Grid Inhomogeneous Solvation Theory.	Chloroform	55-65	GRB2 related adaptor protein 2	Homo sapiens	94-98
32623889-2	2020	ATR-FTIR spectroscopy and quantum chemical calculations were performed on tert-butyl alcohol (t-BuOH) and its binary solutions with CCl4 and CHCl3.	Chloroform	141-146	ATR serine/threonine kinase	Homo sapiens	0-3
32623889-5	2020	Unexpectedly, CCl4 was found not to be an inert solvent and, similar to CHCl3, forms hydrogen-/halogen-bonds (H-/X-bond) with t-BuOH.	Chloroform	72-77	C-C motif chemokine ligand 4	Homo sapiens	14-18
32623889-6	2020	It was observed that the free-OH band in t-BuOH-CHCl3 system is larger and more red-shifted than that in t-BuOH-CCl4 system, indicating the stronger intermolecular interactions in the former system.	Chloroform	48-53	C-C motif chemokine ligand 4	Homo sapiens	112-116
32467161-6	2020	General anesthetics, such as chloroform, isoflurane, diethyl ether, xenon, and propofol, disrupt lipid rafts and activate PLD2.	Chloroform	29-39	phospholipase D2	Homo sapiens	122-126
32289492-3	2020	Hydrophobic complexes were formed between bovine serum albumin (BSA) and either dodecyl sulfate, cetyl trimethylammonium or 1,2-dipalmitoyl-sn-glycero-3-phosphate applying the organic solvent-free method, Bligh-Dyer method and biphasic metathesis reaction either with ethyl acetate or chloroform as organic phase.	Chloroform	285-295	albumin	Homo sapiens	49-62
32335358-1	2020	Investigation of components of the chloroform-soluble and ethyl acetate-soluble extracts of the aerial parts of Chromolaena odorata L. selected by PCSK9 mRNA expression monitoring assay in HepG2 cells led to the isolation of a new stilbene dimer, (+)-8b-epi-ampelopsin A (1), and 30 known compounds (2-31).	Chloroform	35-45	proprotein convertase subtilisin/kexin type 9	Homo sapiens	147-152
32467161-3	2020	Here we show that inhaled anesthetics (chloroform and isoflurane) activate TREK-1 through disruption of phospholipase D2 (PLD2) localization to lipid rafts and subsequent production of signaling lipid phosphatidic acid (PA).	Chloroform	39-49	potassium two pore domain channel subfamily K member 2	Homo sapiens	75-81
32467161-3	2020	Here we show that inhaled anesthetics (chloroform and isoflurane) activate TREK-1 through disruption of phospholipase D2 (PLD2) localization to lipid rafts and subsequent production of signaling lipid phosphatidic acid (PA).	Chloroform	39-49	phospholipase D2	Homo sapiens	104-120
32467161-3	2020	Here we show that inhaled anesthetics (chloroform and isoflurane) activate TREK-1 through disruption of phospholipase D2 (PLD2) localization to lipid rafts and subsequent production of signaling lipid phosphatidic acid (PA).	Chloroform	39-49	phospholipase D2	Homo sapiens	122-126
31743764-11	2020	RESULTS: The results of the study indicate that the chloroform and ethanol extract of Convolvulus pluricaulis showed neuroprotective activity by a significant decrease in lipid peroxidation (p &lt; 0.001) and an increase in superoxide dismutase (p &lt; 0.01, p &lt; 0.001), catalase (p &lt; 0.01, p &lt; 0.001), glutathione (p &lt; 0.001), and total thiol (p &lt; 0.001) levels in extract-treated groups as compared to control group.	Chloroform	52-62	catalase	Rattus norvegicus	274-282
31987857-6	2020	RESULTS: All the investigated VAs (chloroform, halothane, isoflurane, sevoflurane) inhibited both the agonist-induced (pregnenolone sulfate, CIM0216) and heat-activated Ca2+ signals and transmembrane currents in a concentration dependent way in HEK293T cells overexpressing recombinant TRPM3.	Chloroform	35-45	transient receptor potential cation channel subfamily M member 3	Homo sapiens	286-291
31720798-4	2020	Millimolar concentration currents representing a 1:10000 dilution of commercially available chloroform were used in laboratories that augment neuronal Kir3.1/3.2 currents as well as cardiac Kir3.1/3.4.	Chloroform	92-102	potassium inwardly-rectifying channel, subfamily J, member 3	Mus musculus	151-157
32149090-6	2020	Among all fractions, the chloroform fraction of the D. dichotoma displayed the highest cytotoxic activity and was most effective in MCF-7, PC3, and CACO cells (IC50 = 1.93 +- 0.25, 2.2 +- 0.18, and 2.71 +- 0.53 mug/mL, respectively).	Chloroform	25-35	chromobox 8	Homo sapiens	139-142
31778078-4	2022	Pretreatment with chloroform or petroleum ether extracts significantly (p &lt; 0.05) prevented the ISO-induced alteration; they upregulated VEGF expression.	Chloroform	18-28	vascular endothelial growth factor A	Rattus norvegicus	140-144
32378555-6	2020	Compared with the control group, the levels of Abeta40 and Abeta42 declined notably and the activity of BACE1 was inhibited significantly in the APP/PS1 CHO cells after treatment with the chloroform extract of G. delavayi flower.	Chloroform	188-198	beta-secretase 1	Cricetulus griseus	104-109
31102122-3	2019	The fractionation of the chloroform fraction (CF-PL) through chromatographic methods afforded the known compound PL-1.	Chloroform	25-35	lethal, Chr 9, Russell 1	Mus musculus	113-117
31539958-7	2019	Importantly, HAcAms showed 5.83-7.13 x 104 times higher toxicity than the well-clarified DBP chloroform, clearly demonstrating the increased toxicity of HAcAms.	Chloroform	93-103	D-box binding PAR bZIP transcription factor	Homo sapiens	89-92
31496250-4	2019	Moreover, CDB1 (o) reveals blue-/NIR light-induced reversible fluorescent switching behaviors in toluene, chloroform, poly(methyl methacrylate) (PMMA) film, and powder state, while its analogue CDB2 (o) in the powder state exhibits no fluorescence due to a strong intermolecular pi-pi stacking interaction, and the fluorescent switching performance is observed only in toluene and PMMA film.	Chloroform	106-116	transforming growth factor beta induced	Homo sapiens	10-14
31623258-2	2019	Acetylcholinesterase (AChE) enzyme was immobilized onto three gold interfaces with different morphologies, and the sensor response to chloroform was measured.	Chloroform	134-144	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
31623258-2	2019	Acetylcholinesterase (AChE) enzyme was immobilized onto three gold interfaces with different morphologies, and the sensor response to chloroform was measured.	Chloroform	134-144	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
31076338-5	2019	In our investigations of different types of compounds with Vpr inhibitory activity, we found that the CHCl3 soluble, crude extract of the whole Swertia chirata plant inhibited the expression of Vpr in Hela cells harboring the TREx plasmid encoding full-length Vpr (TREx-HeLa-Vpr cells).	Chloroform	102-107	Vpr	Human immunodeficiency virus 1	59-62
31076338-5	2019	In our investigations of different types of compounds with Vpr inhibitory activity, we found that the CHCl3 soluble, crude extract of the whole Swertia chirata plant inhibited the expression of Vpr in Hela cells harboring the TREx plasmid encoding full-length Vpr (TREx-HeLa-Vpr cells).	Chloroform	102-107	Vpr	Human immunodeficiency virus 1	194-197
31076338-5	2019	In our investigations of different types of compounds with Vpr inhibitory activity, we found that the CHCl3 soluble, crude extract of the whole Swertia chirata plant inhibited the expression of Vpr in Hela cells harboring the TREx plasmid encoding full-length Vpr (TREx-HeLa-Vpr cells).	Chloroform	102-107	Vpr	Human immunodeficiency virus 1	194-197
31076338-5	2019	In our investigations of different types of compounds with Vpr inhibitory activity, we found that the CHCl3 soluble, crude extract of the whole Swertia chirata plant inhibited the expression of Vpr in Hela cells harboring the TREx plasmid encoding full-length Vpr (TREx-HeLa-Vpr cells).	Chloroform	102-107	Vpr	Human immunodeficiency virus 1	194-197
31148251-3	2019	Using DBU as the organic base for the reaction of acetone, chloroform and methanol in acetonitrile afforded MMA in 66 % yield.	Chloroform	59-69	monocyte to macrophage differentiation associated	Homo sapiens	108-111
31569451-8	2019	However, the chloroform extract significantly lowered only IL-6 and ESR, but not TNF-alpha or MPO levels.	Chloroform	13-23	interleukin 6	Rattus norvegicus	59-63
31430123-4	2019	Luminescent investigations reveal that Ag3-iah can selectively detect dichloromethane or trichloromethane in tetrachloromethane.	Chloroform	89-105	anterior gradient 3, protein disulphide isomerase family member	Homo sapiens	39-42
30878659-8	2019	Low molecular weight SMPs fractions (MW&lt;10 kDa) were major precursors for DBP in which trichloromethane (TCM) was the most abundant.	Chloroform	90-106	D-box binding PAR bZIP transcription factor	Homo sapiens	77-80
30818765-2	2019	meso-Tetraphenyl-porphyrin chelates (CuII, NiII, CoII) upon reaction wit e.g., itric acid (yellow HNO3, d = 1.52, diluted to 25-50%) in CHCl3 formed a mixture of nitro-derivatives with combined yields of ca 80%.	Chloroform	136-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
31045298-6	2019	The largest temperature dependence is observed for D-1 in CHCl3 , while the temperature effect is less pronounced for L-1 in CHCl3 and for both peptides in CH3 CN.	Chloroform	125-130	immunoglobulin kappa variable 1-16	Homo sapiens	118-121
30954631-7	2019	The metabolic profiling of both atria from relaxin-2-treated and control rats was carried out using two separate ultra-high performance liquid chromatography (UHPLC)-Time of Flight-MS based platforms analyzing methanol and chloroform/methanol extracts combined with a UHPLC-single quadrupole-MS based platform used to analyze aminoacids and with a methanol/water extract platform that covered polar metabolites.	Chloroform	223-233	relaxin 2	Homo sapiens	43-52
30039335-2	2019	Factors that change lipid bilayer composition/properties (including volatile anesthetics, chloroform, chlorpromazine, shear stress, and cell swelling/shrinkage) modify TRESK current, but despite the importance of anionic phospholipids (e.g., PIP2) in the regulation of many ion channels, it remains unknown if membrane lipids affect TRESK function.	Chloroform	90-100	potassium two pore domain channel subfamily K member 18	Homo sapiens	168-173
31702502-7	2019	Upon fractionation, chloroform fraction (Aa.Chm) exhibited the highest antiproliferative activity with IC50 6.55 +- 1.2 microg/ml followed by ethyl acetate (Aa.Et) fraction (IC50, 24.59 +- 0.85 microg/ml) and n-hexane (Aa.Hex) fraction (IC50 29.53 +- 1.5microg/ml).	Chloroform	20-30	CHM Rab escort protein	Homo sapiens	44-47
30565461-3	2019	Here we show that a detoxifying transgene, mammalian cytochrome P450 2e1 can be expressed in a houseplant, Epipremnum aureum, pothos ivy, and that the resulting genetically modified plant has sufficient detoxifying activity against benzene and chloroform to suggest that biofilters using transgenic plants could remove VOCs from home air at useful rates.	Chloroform	244-254	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	53-72
32523324-7	2019	Receptor 2 was also found to form a complex with CsF in chloroform/methanol (4/1, v/v) solution, albeit with a different binding mode than is seen in the solid state.	Chloroform	56-66	colony stimulating factor 2	Homo sapiens	49-52
30077149-6	2018	Chlorination of BP3 and BP4 generated remarkably higher levels of DBPs than chloramination, with high pH conditions facilitating the formation of chloroform but inhibiting the formation of haloacetic acid (HAAs).	Chloroform	146-156	BP3	Homo sapiens	16-19
30387356-6	2018	The decaphyrins were treated with BF3 OEt2/triethylamine in CHCl3 at reflux temperature, followed by column chromatography, to afford bis-BF2 complexes of decaphyrin in 34-40% yields.	Chloroform	60-65	forkhead box G1	Homo sapiens	138-141
30318665-2	2018	SG SH exhibits the largest fluorescent enhancement in chloroform due to supramolecular assembly-induced emission enhancement, while only LG LH turns into supramolecular gel with stimuli responsiveness owing to their most flexible arms.	Chloroform	54-64	N-sulfoglucosamine sulfohydrolase	Homo sapiens	0-5
30077149-6	2018	Chlorination of BP3 and BP4 generated remarkably higher levels of DBPs than chloramination, with high pH conditions facilitating the formation of chloroform but inhibiting the formation of haloacetic acid (HAAs).	Chloroform	146-156	BP4	Homo sapiens	24-27
30320850-8	2018	Coating the ATR element with a LLDPE film (crystallinity = 12%) reduced the detection time for various hydrocarbons, including toluene, benzene and chloroform.	Chloroform	148-158	ATR serine/threonine kinase	Homo sapiens	12-15
30350940-6	2018	Because of the dimerization of the DTBDT in the SM2 core, highly crystalline films with compact lamellae and an enhanced donor/acceptor interdigitation were formed, and all of these factors led to a high efficiency of 8.64% with chloroform and 8.37% with the o-xylene solvent systems.	Chloroform	229-239	SM2	Homo sapiens	48-51
30218295-2	2018	P33 dissolved in chloroform is investigated by steady-state absorption, linear/non-linear fluorescence spectroscopies and time-resolved fluorescence spectroscopy.	Chloroform	17-27	inhibitor of growth family member 1	Homo sapiens	0-3
30224244-8	2018	The RPL4 gene was amplified up to 72 h, ACTB gene up to 14 days and GPD1 gene up to 28 days from tissue fixed in phosphate-buffered formalin using phenol-chloroform-isoamylalcohol protocol for DNA isolation.	Chloroform	154-164	ribosomal protein L4	Homo sapiens	4-8
30377670-7	2018	As compared to model group, the concentrations of AST, ALT, AKP and LDH in chloroform groups and ethyl acetate groups were significantly decreased.	Chloroform	75-85	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	50-53
30375462-5	2018	In addition, electrophysiological recordings from dorsal longitudinal muscle fibers and behavioral observations of TDP-43 flies exposed to the volatile anaesthetics, diethyl ether or chloroform, showed paradoxical responses, which were normalized upon Mpe or Wse treatment.	Chloroform	183-193	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	115-121
30377670-7	2018	As compared to model group, the concentrations of AST, ALT, AKP and LDH in chloroform groups and ethyl acetate groups were significantly decreased.	Chloroform	75-85	glutamic pyruvic transaminase, soluble	Mus musculus	55-58
30007606-3	2018	Such modified CNC (CNC-g-LA) exhibits excellent thermostability and nano-sized dispersion in chloroform.	Chloroform	93-103	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	14-17
30007606-3	2018	Such modified CNC (CNC-g-LA) exhibits excellent thermostability and nano-sized dispersion in chloroform.	Chloroform	93-103	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	19-27
30067911-10	2018	Uncovering chloroform and isoflurane modulatory sites will further our understanding of the TRPV1 molecular machinery and open the possibility of developing site-specific drugs.	Chloroform	11-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	92-97
30258361-5	2018	The CHCl3 fraction was found to inhibit CSC-induced IL-6 expression in human airway epithelial cells and to suppress the infiltration of inflammatory cells (neutrophils and macrophages) and secretion of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in the mouse model.	Chloroform	4-9	interleukin 6	Homo sapiens	52-56
30258361-5	2018	The CHCl3 fraction was found to inhibit CSC-induced IL-6 expression in human airway epithelial cells and to suppress the infiltration of inflammatory cells (neutrophils and macrophages) and secretion of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in the mouse model.	Chloroform	4-9	tumor necrosis factor	Homo sapiens	235-262
30258361-5	2018	The CHCl3 fraction was found to inhibit CSC-induced IL-6 expression in human airway epithelial cells and to suppress the infiltration of inflammatory cells (neutrophils and macrophages) and secretion of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in the mouse model.	Chloroform	4-9	tumor necrosis factor	Homo sapiens	264-273
30258361-5	2018	The CHCl3 fraction was found to inhibit CSC-induced IL-6 expression in human airway epithelial cells and to suppress the infiltration of inflammatory cells (neutrophils and macrophages) and secretion of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in the mouse model.	Chloroform	4-9	interleukin 6	Homo sapiens	279-292
30258361-5	2018	The CHCl3 fraction was found to inhibit CSC-induced IL-6 expression in human airway epithelial cells and to suppress the infiltration of inflammatory cells (neutrophils and macrophages) and secretion of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in the mouse model.	Chloroform	4-9	interleukin 6	Homo sapiens	294-298
30258361-6	2018	Similarly, each of the seven lignans isolated from the CHCl3 fraction also suppressed the infiltration of inflammatory cells (neutrophils and macrophages) and secretion of inflammatory mediators such as reactive oxygen species (ROS), TNF-alpha, and IL-6 in vivo.	Chloroform	55-60	tumor necrosis factor	Homo sapiens	234-243
30036772-4	2018	In the 2,4-D solution without any treatment system (O system), trichloromethane (TCM) as the only detected DBP increased with the increase of chlorine dosage.	Chloroform	63-79	D-box binding PAR bZIP transcription factor	Homo sapiens	107-110
30036772-4	2018	In the 2,4-D solution without any treatment system (O system), trichloromethane (TCM) as the only detected DBP increased with the increase of chlorine dosage.	Chloroform	81-84	D-box binding PAR bZIP transcription factor	Homo sapiens	107-110
30124697-6	2018	In chloroform or CCl4, where disordered H-aggregates are formed, an energy transfer channel among aggregates with different composition and size is observed, leading to the non-radiative decay towards the lower energy dark state of the aggregates.	Chloroform	3-13	C-C motif chemokine ligand 4	Homo sapiens	17-21
30258361-6	2018	Similarly, each of the seven lignans isolated from the CHCl3 fraction also suppressed the infiltration of inflammatory cells (neutrophils and macrophages) and secretion of inflammatory mediators such as reactive oxygen species (ROS), TNF-alpha, and IL-6 in vivo.	Chloroform	55-60	interleukin 6	Homo sapiens	249-253
28659017-1	2018	This paper presents the combination of TiO2/GAC catalyst and NTP for the decomposition of chloroform using a DBD reactor.	Chloroform	90-100	glutaminase	Homo sapiens	44-47
28659017-8	2018	Our findings suggest that the hybrid of NTP with TiO2/GAC will highly be effective in the abatement of chloroform, and the addition of H2O will successfully decline harmful chlorinated by-products.	Chloroform	103-113	glutaminase	Homo sapiens	54-57
29961439-5	2018	The highest value of per cent hydrophobicity was recorded with chloroform in HM1 (L. casei) (97 10 +- 3 35%) and LGG (98 92 +- 1 24%).	Chloroform	63-73	small nuclear ribonucleoprotein U11/U12 subunit 35	Homo sapiens	77-80
29797173-2	2018	Nitric oxide production was inhibited and TNF-alpha secretion was supressed in stimulated RAW cells treated with the chloroform extract and dimethyl octenol of T. decandra.	Chloroform	117-127	tumor necrosis factor	Mus musculus	42-51
30090308-9	2018	In MeOH/CHCl3 (1/1 vol) both compounds selectively bind cyanide to form the corresponding mu(1,2) chelate complexes with a B-C[triple bond, length as m-dash]N-B bridge at their cores.	Chloroform	8-13	glutathione S-transferase mu 1	Homo sapiens	90-96
28641452-3	2018	The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-precipitated and chloroform fractions strongly inhibited the myeloperoxidase activity in ear tissue.	Chloroform	128-138	myeloperoxidase	Mus musculus	172-187
29928328-0	2018	Chloroform fraction of Serratulae chinensis S. Moore suppresses proliferation and induces apoptosis via the phosphatidylinositide 3-kinase/Akt pathway in human gastric cancer cells.	Chloroform	0-10	AKT serine/threonine kinase 1	Homo sapiens	139-142
29491634-9	2018	Experimentally, butanolic tuber fraction confirmed promising antioxidant potential (ABTS: IC50: 271.67 mug/ml; DPPH: IC50: 723.41 mug/ml) with a noteworthy amount of FRAP (195.96 mug/mg), total phenolic content (0.087 mug/mg), and total flavonoid content (7.5 mug/mg) while chloroform fraction (leaves) showed considerable reduction in the cell viability of MCF-7 cell line.	Chloroform	274-284	mechanistic target of rapamycin kinase	Homo sapiens	166-170
29532845-4	2018	Here, we study the tip-sample interaction with polystyrene droplets swollen in chloroform vapour, where we can utilize the solvent vapour concentration to adjust the specimen"s mechanical properties from a stiff solid to a fluid film.	Chloroform	79-89	TOR signaling pathway regulator	Homo sapiens	19-22
29222980-5	2018	DOX more strongly bound to HSA than silica also affects structure of interfacial water layers that depends on dispersion media because chloroform as immiscible with water changes the water organization to enlarge water structures.	Chloroform	135-145	albumin	Homo sapiens	27-30
29950069-6	2018	The results showed that the chloroform fraction extracted from EER could significantly increase the moisture content in mice feces, duodenum and colon, and decrease AQP1 protein expression level, increase AQP3 and AQP4 protein expression levels in the colon.	Chloroform	28-38	aquaporin 1	Mus musculus	165-169
29950069-6	2018	The results showed that the chloroform fraction extracted from EER could significantly increase the moisture content in mice feces, duodenum and colon, and decrease AQP1 protein expression level, increase AQP3 and AQP4 protein expression levels in the colon.	Chloroform	28-38	aquaporin 3	Mus musculus	205-209
29950069-6	2018	The results showed that the chloroform fraction extracted from EER could significantly increase the moisture content in mice feces, duodenum and colon, and decrease AQP1 protein expression level, increase AQP3 and AQP4 protein expression levels in the colon.	Chloroform	28-38	aquaporin 4	Mus musculus	214-218
29555591-3	2018	To further emphasize the significance of this moiety for developing Cu(II) ionophores, we herein designed a beta-diketo analog of piperlongumine, PL-I, characterized by the presence of high proportion of the keto-enol form in dimethylsulfoxide and chloroform, and identified its keto-enol structure by NMR and theoretical calculations.	Chloroform	248-258	amyloid beta precursor protein	Homo sapiens	106-112
29555591-3	2018	To further emphasize the significance of this moiety for developing Cu(II) ionophores, we herein designed a beta-diketo analog of piperlongumine, PL-I, characterized by the presence of high proportion of the keto-enol form in dimethylsulfoxide and chloroform, and identified its keto-enol structure by NMR and theoretical calculations.	Chloroform	248-258	serpin family F member 2	Homo sapiens	146-150
29536690-9	2018	PAF expression in TCM group and methylprednisolone group were lower than that of model group at 7, 14 day afer treatment significantly (P&lt;0.05); but there were no significant difference between TCM group and methylprednisolone group (P&gt;0.05).	Chloroform	18-21	PCNA clamp associated factor	Rattus norvegicus	0-3
29292455-4	2018	In this work, we monitored the chain scission of the model polymer MEH-PPV in chloroform solutions under different conditions by assessing its molecular weight using gel permeation chromatography and optical spectral measurements.	Chloroform	78-88	epoxide hydrolase 1	Homo sapiens	67-70
29669987-4	2018	At 24 h after intraperitoneal injection of 0.5 mL/kg chloroform, serum alanine aminotransferase (ALT) levels were increased significantly; extensive necrosis and inflammation occurred as identified by histological examinations.	Chloroform	53-63	glutamic pyruvic transaminase, soluble	Mus musculus	71-95
29669987-4	2018	At 24 h after intraperitoneal injection of 0.5 mL/kg chloroform, serum alanine aminotransferase (ALT) levels were increased significantly; extensive necrosis and inflammation occurred as identified by histological examinations.	Chloroform	53-63	glutamic pyruvic transaminase, soluble	Mus musculus	97-100
29669987-8	2018	Further mechanistic insights demonstrated that chloroform up-regulated pro-inflammatory cytokine, IL-1beta, in the livers and blood, which was suppressed by 3-MA.	Chloroform	47-57	interleukin 1 beta	Mus musculus	98-106
29669987-9	2018	Surprisingly, Western blots results showed that after 24-hours of chloroform treatment 3-MA activated autophagy as indicated by decreased levels of LC3B II and p62 protein.	Chloroform	66-76	nucleoporin 62	Mus musculus	160-163
29273919-7	2017	The greatest cytotoxic activity against both of the evaluated cell lines was obtained from the chloroform extract of Labrenzia aggregata USBA 371 which had an IC50 &lt; 6 mug mL-1.	Chloroform	95-105	L1 cell adhesion molecule	Mus musculus	175-179
29344237-0	2017	Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.	Chloroform	0-10	AKT serine/threonine kinase 1	Homo sapiens	116-119
29344237-0	2017	Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.	Chloroform	0-10	mitogen-activated protein kinase 1	Homo sapiens	124-127
28671842-3	2017	Crystal-to-crystal transformations of CPs 1-6 were reversible under heat or in an appropriate solvent (acetonitrile, dichloromethane, chloroform, or benzene).	Chloroform	134-144	carbamoyl-phosphate synthase 1	Homo sapiens	38-43
29143006-2	2017	PDI-1, containing a carboxylic acid group, exhibits H-aggregation in a non-polar solvent decalin while in THF or chloroform it remains in the monomeric form.	Chloroform	113-123	peptidyl arginine deiminase 1	Homo sapiens	0-5
28737917-3	2017	The nuC-H band of donor CHCl3 undergoes a large red shift of ~33 cm-1.	Chloroform	24-29	nucleobindin 1	Homo sapiens	4-7
28445820-3	2017	Ph2(PDPP)2 exhibits high thermal stability and it can be soluble in common organic solvents such as chloroform and tetrahydrofuran.	Chloroform	100-110	polyhomeotic homolog 2	Homo sapiens	0-10
28610486-6	2017	The characterization results showed that resveratrol in glycyrrhizic acid-conjugated human serum albumin nanoparticles wrapping resveratrol nanoparticles existed in amorphous state and the residual amounts of chloroform and methanol in nanoparticles were separately less than the international conference on harmonization (ICH) limit.	Chloroform	209-219	albumin	Homo sapiens	91-104
28857572-2	2017	Recently, a very straightforward methodology for fabricating asymmetric polymersome was developed by Lodge"s group through the coassembly of polystyrene-b-poly(ethylene oxide) (PS-b-PEO) and polybutadiene-b-poly(ethylene oxide) (PB-b-PEO) block copolymers at the interface of a polystyrene/polybutadiene/chloroform (PS/PB/CHCl3) emulsion.	Chloroform	304-314	surfactant protein B	Homo sapiens	177-179
28857572-2	2017	Recently, a very straightforward methodology for fabricating asymmetric polymersome was developed by Lodge"s group through the coassembly of polystyrene-b-poly(ethylene oxide) (PS-b-PEO) and polybutadiene-b-poly(ethylene oxide) (PB-b-PEO) block copolymers at the interface of a polystyrene/polybutadiene/chloroform (PS/PB/CHCl3) emulsion.	Chloroform	304-314	twinkle mtDNA helicase	Homo sapiens	182-185
28857572-2	2017	Recently, a very straightforward methodology for fabricating asymmetric polymersome was developed by Lodge"s group through the coassembly of polystyrene-b-poly(ethylene oxide) (PS-b-PEO) and polybutadiene-b-poly(ethylene oxide) (PB-b-PEO) block copolymers at the interface of a polystyrene/polybutadiene/chloroform (PS/PB/CHCl3) emulsion.	Chloroform	322-327	surfactant protein B	Homo sapiens	177-179
28857572-2	2017	Recently, a very straightforward methodology for fabricating asymmetric polymersome was developed by Lodge"s group through the coassembly of polystyrene-b-poly(ethylene oxide) (PS-b-PEO) and polybutadiene-b-poly(ethylene oxide) (PB-b-PEO) block copolymers at the interface of a polystyrene/polybutadiene/chloroform (PS/PB/CHCl3) emulsion.	Chloroform	322-327	twinkle mtDNA helicase	Homo sapiens	182-185
28665506-1	2017	The formation of complexes between hexafluorophosphate (PF6- ) and tetraisobutyloctahydroxypyridine[4]arene has been thoroughly studied in the gas phase (ESI-QTOF-MS, IM-MS, DFT calculations), in the solid state (X-ray crystallography), and in chloroform solution (1 H, 19 F, and DOSY NMR spectroscopy).	Chloroform	244-254	sperm associated antigen 17	Homo sapiens	56-59
28700694-8	2017	In addition to the expected deficiencies in dotriacontanal and dotriacontan-1-ol for gl1 seedlings, an unexpected increase in fatty acid recovery was observed in gl1 seedlings extracted in chloroform, suggesting that chloroform extracts lipids from internal tissues of gl1 seedlings.	Chloroform	217-227	glossy 1	Zea mays	162-165
28700694-8	2017	In addition to the expected deficiencies in dotriacontanal and dotriacontan-1-ol for gl1 seedlings, an unexpected increase in fatty acid recovery was observed in gl1 seedlings extracted in chloroform, suggesting that chloroform extracts lipids from internal tissues of gl1 seedlings.	Chloroform	217-227	glossy 1	Zea mays	162-165
28164404-4	2017	Detailed analysis of the kinetic data yields the association constant (K=3x102  m-1 ) of the putative HCl2 species in chloroform.	Chloroform	118-128	HCL2	Homo sapiens	102-106
28890764-6	2017	Chloroform precipitated bacteriocin retained antagonistic activities in the presence of catalase and lysozyme; and was completely inactivated by Proteinase K treatment.	Chloroform	0-10	prtP	Lactococcus lactis	145-155
28088446-6	2017	We further characterized that these unique vesicles are soluble in organic solvents (e.g. chloroform-methanol mixture and ethanol) which can be prevented by a lipid-stabilizing fixative (e.g. OsO4) and that they are co-localized with, but do not monopolize, the major markers (e.g. caveolin-1 and GM1) for lipid rafts (a nano-sized detergent-resistant domains in the plasma membrane).	Chloroform	90-100	caveolin 1	Homo sapiens	282-292
28649844-1	2017	Phytochemical investigation for a chloroform-soluble extract of dried Morus alba fruits, selected by proprotein convertase subtilisin-kexin type 9 (PCSK9) mRNA expression monitoring assay in HepG2 cells, led to the isolation of a new benzofuran, isomoracin D (1), and a naturally occurring compound, N-(N-benzoyl-l-phenylalanyl)-l-phenylalanol (2), along with 13 known compounds (3-15).	Chloroform	34-44	proprotein convertase subtilisin/kexin type 9	Homo sapiens	148-153
28424844-6	2017	THM1, was found to couple growth with dehalogenation of chloroform, bromoform, and 1,1,1-TCA.	Chloroform	56-66	tetratricopeptide repeat domain 21B	Homo sapiens	0-4
28424844-7	2017	Strain THM1 harbors a newly identified reductive dehalogenase (RDase), ThmA, which catalyzes chloroform, bromoform, and 1,1,1-TCA dehalogenation.	Chloroform	93-103	tetratricopeptide repeat domain 21B	Homo sapiens	7-11
28424844-7	2017	Strain THM1 harbors a newly identified reductive dehalogenase (RDase), ThmA, which catalyzes chloroform, bromoform, and 1,1,1-TCA dehalogenation.	Chloroform	93-103	THMA	Homo sapiens	71-75
28638077-3	2017	Introduction of PPI block in the block copolymer architecture enabled PTh- b -PPI film to exhibit solid-to-liquid crystal phase transition by exposure to chloroform vapour, accompanied with colour change (purple-to-yellow), which is the first report on a new phenomenon of "vapour-induced liquid crystallinity".	Chloroform	154-164	parathyroid hormone	Homo sapiens	70-73
28498458-0	2017	Chloroform fraction of Scutellaria barbata D. Don inhibits the growth of colorectal cancer cells by activating miR-34a.	Chloroform	0-10	microRNA 34a	Homo sapiens	111-118
30263568-0	2017	Inhibitory effect of Zizania latifolia chloroform fraction on allergy-related mediator production in RBL-2H3 cells.	Chloroform	39-49	RB transcriptional corepressor like 2	Rattus norvegicus	101-106
27397543-8	2016	Application of arachidonic acid (10 mumol/L), chloroform (1 mmol/L) or etomidate (10 mumol/L) substantially increased TREK-1 channel currents in CHO/hTREK-1 cells.	Chloroform	46-56	potassium two pore domain channel subfamily K member 2	Homo sapiens	118-124
27643755-6	2017	In the laboratory, NO emission pulses were up to 19x greater in chloroform-treated soils than in the controls, and these abiotic pulses increased with elevation as pH decreased (6.2-4.4) and soil organic matter (SOM) increased (18-157 mg C g-1 ).	Chloroform	64-74	erythrocyte membrane protein band 4.1 like 4B	Homo sapiens	238-243
28539724-15	2017	SUMMARY: Nine irregular seco-limonoids were isolated from Swietenia mahogani.Total extract and CHCl3 fraction of S. mahogani showed the significant inhibitory activities on 3T3-L1 cell differentiation.A tigloyl residue at C-3 in an aglycone may play a role in the anti-proliferative activity on adipogenesis.	Chloroform	95-100	complement component 3	Mus musculus	222-225
27754693-2	2016	The chloroform extract of the leaves of C. urticifolia showed potent inhibition of recombinant human monoamine oxidases (MAO-A and -B).	Chloroform	4-14	monoamine oxidase A	Homo sapiens	121-133
28177029-1	2017	Co-assembly of n-type semiconductors NDI and PDI with p-type pyrene derivatives resulted in the formation of stable organogels, which was induced by the strong charge transfer (CT) interactions between acceptors and donors in chloroform.	Chloroform	226-236	peptidyl arginine deiminase 1	Homo sapiens	45-48
28401088-4	2017	In brief, RSL powder was fractionated into n-hexane, chloroform, ethyl acetate, n-butanol, and water-soluble fractions.	Chloroform	53-63	regulator of sex limited protein-Slp	Mus musculus	10-13
28401088-9	2017	Furthermore, the expression of nuclear factor-kappa B (NF-kappaB), the key regulator of the transcriptional activation of the inflammatory cytokine genes, was reduced by the RSL chloroform fraction.	Chloroform	178-188	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	31-53
28401088-9	2017	Furthermore, the expression of nuclear factor-kappa B (NF-kappaB), the key regulator of the transcriptional activation of the inflammatory cytokine genes, was reduced by the RSL chloroform fraction.	Chloroform	178-188	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	55-64
28401088-9	2017	Furthermore, the expression of nuclear factor-kappa B (NF-kappaB), the key regulator of the transcriptional activation of the inflammatory cytokine genes, was reduced by the RSL chloroform fraction.	Chloroform	178-188	regulator of sex limited protein-Slp	Mus musculus	174-177
28197305-5	2017	CEHR2 transfers Ca2+ from an aqueous solution into CHCl3 to greater extent than alkali metal cations and Mg2+.	Chloroform	51-56	carbonic anhydrase 2	Homo sapiens	16-19
27380306-5	2016	Molar absorptivity and Sandell"s sensitivity of osmium(VIII)-2NBATCH complex in chloroform is 8.94x10(3)Lmol(-1)cm(-1) and 0.021mugcm(-2), respectively.	Chloroform	80-90	cytochrome c oxidase subunit 8A	Homo sapiens	55-59
27494316-4	2016	Chloroform was found as a chlorinated intermediate during the UV/chlorine reaction of both geosmin and 2-MIB.	Chloroform	0-10	MIB E3 ubiquitin protein ligase 1	Homo sapiens	105-108
27397543-8	2016	Application of arachidonic acid (10 mumol/L), chloroform (1 mmol/L) or etomidate (10 mumol/L) substantially increased TREK-1 channel currents in CHO/hTREK-1 cells.	Chloroform	46-56	potassium two pore domain channel subfamily K member 2	Homo sapiens	149-156
27231877-7	2016	The formation of chloroform is affected by Cl(-) concentration, by concentrations and ratios of biogenic substrates (TOC and AOX), and by the ratios of the substrates and the product (feedback control by chloroform itself).	Chloroform	17-27	acyl-CoA oxidase 1	Homo sapiens	125-128
27293214-7	2016	Acid hydrolysis of MUP with 6 N HCl liberates N-linked Hcy as Hcy-thiolactone, which is then extracted with chloroform/methanol.	Chloroform	108-118	major urinary protein 21	Mus musculus	19-22
27375189-2	2016	Pl-C extract, prepared from dried leaves by ultrasound assisted maceration (UAM) in chloroform, was profiled through using GC-MS techniques.	Chloroform	84-94	heparan sulfate proteoglycan 2	Homo sapiens	0-4
28920386-5	2016	UGT1A1 activity was inhibited by chloroform extract in rat liver microsomes and human liver microsomes (based on genkwanin, IC50=8.76, 10.36 mumol L-1).	Chloroform	33-43	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-6
28920386-7	2016	In conclusion, the results indicated that chloroform extract showed different inhibitory effects on UGTs and UGT1A1 activity, which may be one of the mechanisms of liver injury induced by Genkwa Flos.	Chloroform	42-52	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	109-115
28920386-0	2016	[In vitro effects of Genkwa Flos chloroform extract on activity of human liver microsomes UGTs and UGT1A1].	Chloroform	33-43	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	99-105
28920386-1	2016	To predict the mechanism of liver injury induced by Genkwa Flos, we investigated the effect of chloroform extract on UGTs and UGT1A1 activities of the liver microsomes in rat and human.	Chloroform	95-105	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	126-132
27132939-1	2016	Cyclization of the ether enyne 1 catalyzed by [Ru]NCCH3(+) ([Ru] = Cp(PPh3)2Ru) in CHCl3 generates a diastereomeric mixture of the substituted tetrahydropyran 11.	Chloroform	83-88	caveolin 1	Homo sapiens	70-74
27430329-14	2016	The in vitro studies indicated that chloroform fraction at 15 mug/ml more effectively inhibited the TNF-alpha induced synthesis of NFkB (85.0 +- 8.12 %, IC50 = 5.98 mug/ml) and LPS-instigated nitric oxide (78.23 +- 2.39 %, IC50 = 6.59 mug/ml) synthesis.	Chloroform	36-46	tumor necrosis factor	Homo sapiens	100-109
27430329-16	2016	Moreover, chloroform fraction had the ability to decrease (P &lt;0.001) the influx of leukocytes and the concentration of inflammatory mediators; TNF-alpha, NO, IL-6 and PGE2 in air pouch exudate.	Chloroform	10-20	tumor necrosis factor	Homo sapiens	146-155
27761064-7	2016	RESULTS: GS extracts showed differential effect on CYP activities in the following order of inhibitory potency: ethyl acetate &gt; Chloroform &gt; methanol &gt; n-hexane &gt; aqueous &gt; DGA.	Chloroform	131-141	peptidylprolyl isomerase G	Homo sapiens	51-54
27761064-9	2016	The ethyl acetate and chloroform extract exhibited moderate inhibition towards CYP1A2 and 3A4.	Chloroform	22-32	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	79-85
27761064-11	2016	CONCLUSION: The results of our study revealed that phytoconstituents contained in GS, particularly in ethyl acetate and chloroform extracts, were able to inhibit CYP1A2, 3A4 and 2C9.	Chloroform	120-130	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	162-168
26797827-4	2016	Urine samples from 15 Fabry patients and 21 healthy control subjects were processed to extract Gb3 by mixing equal volumes of urine, methanol containing an internal standard, and chloroform followed by sonication and centrifugation.	Chloroform	179-189	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	95-98
27114072-1	2016	The reaction of Fe(eta-C5H4NHC(O)PPh2)2 () with PtX2(PPh3)2 selectively formed cage-shaped complexes formulated as [(PtX)4()6]X4 CHCl3 (X = Cl, Br), in which the four square-planar Pt fragments were situated at each vertex and the six s were located in each side of a tetrahedral framework and hydrogen bonds existed between the NH groups in s and X(-) ions inside the cage.	Chloroform	129-134	endothelin receptor type A	Homo sapiens	19-22
27114072-1	2016	The reaction of Fe(eta-C5H4NHC(O)PPh2)2 () with PtX2(PPh3)2 selectively formed cage-shaped complexes formulated as [(PtX)4()6]X4 CHCl3 (X = Cl, Br), in which the four square-planar Pt fragments were situated at each vertex and the six s were located in each side of a tetrahedral framework and hydrogen bonds existed between the NH groups in s and X(-) ions inside the cage.	Chloroform	129-134	paired like homeodomain 2	Homo sapiens	48-52
27114072-1	2016	The reaction of Fe(eta-C5H4NHC(O)PPh2)2 () with PtX2(PPh3)2 selectively formed cage-shaped complexes formulated as [(PtX)4()6]X4 CHCl3 (X = Cl, Br), in which the four square-planar Pt fragments were situated at each vertex and the six s were located in each side of a tetrahedral framework and hydrogen bonds existed between the NH groups in s and X(-) ions inside the cage.	Chloroform	129-134	protein phosphatase 4 catalytic subunit	Homo sapiens	53-57
27075974-2	2016	The products are obtained by selective alkoxycarbonylation catalyzed by Pd2(dba)3, 1,4-bis(diphenylphisphino)butane (dppb), and syngas (CO/H2) in chloroform/alcohol.	Chloroform	146-156	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	72-75
26659559-2	2016	It was demonstrated that BP8-C is an efficient gelator which can gel various organic solvents, such as ethanol, benzene, toluene, chloroform, etc.	Chloroform	130-140	BP8	Homo sapiens	25-28
27168755-7	2016	Flowcytometry and annexin-V analysis indicated that the chloroform fraction induced necrosis in MCF-7 cells.	Chloroform	56-66	annexin A5	Homo sapiens	18-27
26659559-3	2016	Both an opaque gel (O-gel) and a transparent gel (T-gel), which is more stable, were obtained with BP8-C in chloroform at different incubation temperatures.	Chloroform	108-118	BP8	Homo sapiens	99-102
26593327-3	2016	The macrocycles bind anions that were once considered too weak to be coordinated, such as PF6 (-) , with surprisingly high affinities (beta2 =10(11)  M(-2) in 80:20 chloroform/methanol) and positive cooperativity, alpha=(4 K2 /K1 )=1200.	Chloroform	165-175	sperm associated antigen 17	Homo sapiens	90-93
26654547-5	2016	When both dry BMP-7 and VEGF were processed with chloroform, as is the case during the electrospraying process, reduced concentrations of the GFs were detected by ELISA; however, the biological effect on myoblast cells (C2C12) or endothelial cells (HUVECs) was unaffected.	Chloroform	49-59	bone morphogenetic protein 7	Mus musculus	14-19
26654547-5	2016	When both dry BMP-7 and VEGF were processed with chloroform, as is the case during the electrospraying process, reduced concentrations of the GFs were detected by ELISA; however, the biological effect on myoblast cells (C2C12) or endothelial cells (HUVECs) was unaffected.	Chloroform	49-59	vascular endothelial growth factor A	Mus musculus	24-28
26677968-5	2016	The reaction of bis-NPN alkyl complexes with CHCl3 is the simplest and most reliable protocol to synthesize bis-NPN-chlorido complexes [(NPN(tBu))2Ln-Cl] (Ln = Sc (12), Y (13), Nd (14), Sm (15), Gd (16), Tb (17), Yb (18) and Lu (19)), which can become new post-metallocene alternatives to the prominent organolanthanide building blocks [Cp*2LnX].	Chloroform	45-50	ligand of numb-protein X 1	Homo sapiens	341-344
26652192-4	2016	The surface-modified membrane, when used with chloroform-based solvent, exhibited superb permeate flux, breakthrough pressure, and also separation yield: it allowed separation of 95.5 +- 1.2% of converted lipid (FAME) in the chloroform phase from the water/MeOH phase with microalgal debris.	Chloroform	46-56	benign adult familial myoclonic epilepsy 1	Homo sapiens	212-216
26652192-4	2016	The surface-modified membrane, when used with chloroform-based solvent, exhibited superb permeate flux, breakthrough pressure, and also separation yield: it allowed separation of 95.5 +- 1.2% of converted lipid (FAME) in the chloroform phase from the water/MeOH phase with microalgal debris.	Chloroform	225-235	benign adult familial myoclonic epilepsy 1	Homo sapiens	212-216
26593327-3	2016	The macrocycles bind anions that were once considered too weak to be coordinated, such as PF6 (-) , with surprisingly high affinities (beta2 =10(11)  M(-2) in 80:20 chloroform/methanol) and positive cooperativity, alpha=(4 K2 /K1 )=1200.	Chloroform	165-175	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	135-140
26304751-6	2015	The expression of the FSHR gene was greater (P&lt;0.03) with the TCM-C than TCM-S treatment, while the relative amounts of mRNA for IGF1 was greater (P&lt;0.02) with MEM-S than TCM-S treatments and for VEGF was greater (P&lt;0.02) with MEM-C than TCM-C treatment.	Chloroform	76-81	follicle stimulating hormone receptor	Bos taurus	22-26
26474944-0	2015	Chloroform upregulates early growth response-1-dependent thymic stromal lymphopoietin expression via the JNK and ERK pathways in human keratinocytes.	Chloroform	0-10	mitogen-activated protein kinase 8	Homo sapiens	105-108
26474944-0	2015	Chloroform upregulates early growth response-1-dependent thymic stromal lymphopoietin expression via the JNK and ERK pathways in human keratinocytes.	Chloroform	0-10	mitogen-activated protein kinase 1	Homo sapiens	113-116
26474944-5	2015	METHODS: The present study demonstrates dose-dependent increases of TSLP protein and mRNA levels in keratinocytes following exposure to chloroform.	Chloroform	136-146	thymic stromal lymphopoietin	Homo sapiens	68-72
27333564-2	2016	The chloroform-extracted complex has a composition of 2:2:2 under the optimum conditions (pH 4.8-5.2, extraction time 3 min, concentration of TAO 3.4 x 10(-4) mol dm(-3), and concentration of TTC 9.4 x 10(-4) mol dm(-3)) and could be regarded as a dimer (D) of two 1:1:1 species (S) presented by the formula (TT+)[VO2(TAO)].	Chloroform	4-14	tetratricopeptide repeat domain 9	Homo sapiens	192-197
26474944-6	2015	We further investigated the regulatory mechanisms of chloroform-induced TSLP expression in human keratinocytes.	Chloroform	53-63	thymic stromal lymphopoietin	Homo sapiens	72-76
26474944-7	2015	RESULTS: Chloroform induces early growth response-1 (Egr-1) protein expression in human keratinocytes.	Chloroform	9-19	early growth response 1	Homo sapiens	53-58
26474944-9	2015	Inhibition of phosphorylated JNK and ERK significantly downregulated Egr-1 expression, which was subsequently associated with reduced TSLP expression in chloroform-exposed human keratinocytes.	Chloroform	153-163	mitogen-activated protein kinase 8	Homo sapiens	29-32
26474944-9	2015	Inhibition of phosphorylated JNK and ERK significantly downregulated Egr-1 expression, which was subsequently associated with reduced TSLP expression in chloroform-exposed human keratinocytes.	Chloroform	153-163	mitogen-activated protein kinase 1	Homo sapiens	37-40
26474944-9	2015	Inhibition of phosphorylated JNK and ERK significantly downregulated Egr-1 expression, which was subsequently associated with reduced TSLP expression in chloroform-exposed human keratinocytes.	Chloroform	153-163	early growth response 1	Homo sapiens	69-74
26474944-9	2015	Inhibition of phosphorylated JNK and ERK significantly downregulated Egr-1 expression, which was subsequently associated with reduced TSLP expression in chloroform-exposed human keratinocytes.	Chloroform	153-163	thymic stromal lymphopoietin	Homo sapiens	134-138
26474944-10	2015	Moreover, treatment of Egr-1 siRNA abolished chloroform-induced TSLP protein expression and TSLP promoter transcriptional activation.	Chloroform	45-55	early growth response 1	Homo sapiens	23-28
26474944-10	2015	Moreover, treatment of Egr-1 siRNA abolished chloroform-induced TSLP protein expression and TSLP promoter transcriptional activation.	Chloroform	45-55	thymic stromal lymphopoietin	Homo sapiens	64-68
26474944-11	2015	CONCLUSIONS: Taken together, these findings suggest that, in human keratinocytes, the upregulation of TSLP by chloroform is induced through an Egr-1-dependent mechanism that requires the c-JNK and ERK pathways.	Chloroform	110-120	thymic stromal lymphopoietin	Homo sapiens	102-106
26474944-11	2015	CONCLUSIONS: Taken together, these findings suggest that, in human keratinocytes, the upregulation of TSLP by chloroform is induced through an Egr-1-dependent mechanism that requires the c-JNK and ERK pathways.	Chloroform	110-120	early growth response 1	Homo sapiens	143-148
26474944-11	2015	CONCLUSIONS: Taken together, these findings suggest that, in human keratinocytes, the upregulation of TSLP by chloroform is induced through an Egr-1-dependent mechanism that requires the c-JNK and ERK pathways.	Chloroform	110-120	mitogen-activated protein kinase 8	Homo sapiens	189-192
26474944-11	2015	CONCLUSIONS: Taken together, these findings suggest that, in human keratinocytes, the upregulation of TSLP by chloroform is induced through an Egr-1-dependent mechanism that requires the c-JNK and ERK pathways.	Chloroform	110-120	mitogen-activated protein kinase 1	Homo sapiens	197-200
26474944-12	2015	Our results suggest that exposure to chloroform may aggravate allergic skin diseases such as AD through Egr-1-dependent TSLP regulation.	Chloroform	37-47	early growth response 1	Homo sapiens	104-109
26474944-12	2015	Our results suggest that exposure to chloroform may aggravate allergic skin diseases such as AD through Egr-1-dependent TSLP regulation.	Chloroform	37-47	thymic stromal lymphopoietin	Homo sapiens	120-124
26481652-13	2015	Significant cytotoxicity against human leukemia (THP-1) cell line was exhibited by the chloroform and n-hexane fruit extracts with IC50 4.52 and 3.49 mug/ml respectively.	Chloroform	87-97	GLI family zinc finger 2	Homo sapiens	49-54
26304751-6	2015	The expression of the FSHR gene was greater (P&lt;0.03) with the TCM-C than TCM-S treatment, while the relative amounts of mRNA for IGF1 was greater (P&lt;0.02) with MEM-S than TCM-S treatments and for VEGF was greater (P&lt;0.02) with MEM-C than TCM-C treatment.	Chloroform	65-68	follicle stimulating hormone receptor	Bos taurus	22-26
25885117-2	2015	CHCl3 and CHBr3 were the dominant compounds in air and water of the Cl-SP and Br-SP, respectively.	Chloroform	0-5	calmodulin like 5	Homo sapiens	68-83
26108919-3	2015	Further, the RGO/SnO2 QD based sensor shows good selectivity for H2 and LPG in the presence of other interfering gases such as ammonia, chloroform, toluene, benzene, acetone, n-butylacetate, acetic acid and formic acid.	Chloroform	136-146	strawberry notch homolog 1	Homo sapiens	17-20
25941966-1	2015	Fluorescent solid 5-pyridylimidazobenzothiadiazole displays a remarkable solvatofluorochromism and with Zn(AcO)2 and Cd(AcO)2, either in solution or under solvent-free conditions, forms ion-pair complexes that in the solid state can be discriminated and separated by fluorescence measurements and selective extraction with diethyl ether or chloroform.	Chloroform	340-350	aconitase 2	Homo sapiens	107-112
25953616-0	2015	The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane.	Chloroform	89-99	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-29
25953616-7	2015	The results revealed that chloroform activates DRG neurons via TRPV1 activation.	Chloroform	26-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	63-68
25953616-8	2015	Furthermore, chloroform activates TRPV1, and it also activates TRPM8 and functions as a potent inhibitor of the noxious chemical receptor TRPA1.	Chloroform	13-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	34-39
25953616-8	2015	Furthermore, chloroform activates TRPV1, and it also activates TRPM8 and functions as a potent inhibitor of the noxious chemical receptor TRPA1.	Chloroform	13-23	transient receptor potential cation channel subfamily M member 8	Homo sapiens	63-68
25953616-8	2015	Furthermore, chloroform activates TRPV1, and it also activates TRPM8 and functions as a potent inhibitor of the noxious chemical receptor TRPA1.	Chloroform	13-23	transient receptor potential cation channel subfamily A member 1	Homo sapiens	138-143
25953616-9	2015	The results also indicate that residues in the outer pore region of TRPV1 previously thought to be required for either proton or heat activation of the channel are also required for activation by chloroform and isoflurane.	Chloroform	196-206	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-73
26100408-0	2015	Vanda roxburghii chloroform extract as a potential source of polyphenols with antioxidant and cholinesterase inhibitory activities: identification of a strong phenolic antioxidant.	Chloroform	17-27	butyrylcholinesterase	Homo sapiens	94-108
26100408-10	2015	Likewise, the chloroform extract exhibited the highest inhibition against both the acetylcholinesterase and butyrylcholinesterase enzymes with IC50 values of 221.13 and 82.51 mug/ml, respectively.	Chloroform	14-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-103
26100408-10	2015	Likewise, the chloroform extract exhibited the highest inhibition against both the acetylcholinesterase and butyrylcholinesterase enzymes with IC50 values of 221.13 and 82.51 mug/ml, respectively.	Chloroform	14-24	butyrylcholinesterase	Homo sapiens	108-129
26100408-13	2015	CONCLUSION: These results suggest that the chloroform extract of V. roxburghii, possibly due to its phenolic compounds, exert potential antioxidant and cholinesterase inhibitory activities, which may be useful in the treatment of AD.	Chloroform	43-53	butyrylcholinesterase	Homo sapiens	152-166
25924055-7	2015	On the basis of the DFT calculations, we found that HCCl3 can be formed by ( )CCl3 and :CCl3(-)* on a deprotonated vivianite surface (an adsorbate on vivianite is denoted using an asterisk).	Chloroform	52-57	C-C motif chemokine ligand 3	Homo sapiens	78-82
25961364-3	2015	An optimal concentration of phosphate buffer for ethanol-chloroform treatment results in good recovery of CAT, SOD, and CA after extraction.	Chloroform	57-67	catalase	Homo sapiens	106-109
25961364-3	2015	An optimal concentration of phosphate buffer for ethanol-chloroform treatment results in good recovery of CAT, SOD, and CA after extraction.	Chloroform	57-67	superoxide dismutase 1	Homo sapiens	111-114
25941966-1	2015	Fluorescent solid 5-pyridylimidazobenzothiadiazole displays a remarkable solvatofluorochromism and with Zn(AcO)2 and Cd(AcO)2, either in solution or under solvent-free conditions, forms ion-pair complexes that in the solid state can be discriminated and separated by fluorescence measurements and selective extraction with diethyl ether or chloroform.	Chloroform	340-350	aconitase 2	Homo sapiens	120-125
25305621-2	2015	The charge-transfer interaction of the PPD2 electron donor and the PA acceptor has been studied in CHCl3.	Chloroform	99-104	limb development membrane protein 1	Homo sapiens	39-43
25305621-5	2015	On the other hand, the 1:31/2 iodine-PPD2 heptaiodide (I7(-)) charge-transfer complex has been studied spectrophotometrically in chloroform at room temperature with general formula [(PPD2)](+)I7(-).	Chloroform	129-139	limb development membrane protein 1	Homo sapiens	37-41
25514132-6	2015	Chloroform and HAA represented, respectively, only 1-8% and 14-15% of adsorbable organic halides (AOX) by monochloramination but up to 29% and 39% of AOX by chlorination.	Chloroform	0-10	acyl-CoA oxidase 1	Homo sapiens	98-101
25352249-4	2015	This study presents a simple method for the purification of mouse liver catalase using ethanol-chloroform treatment, sodium sulfate fractionation, dialysis and Sephadex G-200 gel filtration chromatography.	Chloroform	95-105	catalase	Mus musculus	72-80
26477797-0	2015	Chloroform Extract of Solanum lyratum Induced G0/G1 Arrest via p21/p16 and Induced Apoptosis via Reactive Oxygen Species, Caspases and Mitochondrial Pathways in Human Oral Cancer Cell Lines.	Chloroform	0-10	H3 histone pseudogene 16	Homo sapiens	63-66
26477797-0	2015	Chloroform Extract of Solanum lyratum Induced G0/G1 Arrest via p21/p16 and Induced Apoptosis via Reactive Oxygen Species, Caspases and Mitochondrial Pathways in Human Oral Cancer Cell Lines.	Chloroform	0-10	cyclin dependent kinase inhibitor 2A	Homo sapiens	67-70
26402444-6	2015	RESULTS: The percentage of CD8+ Tcm from pancreatic adenocarcinoma was higher than the healthy control (16.79 +- 9.43% vs. 11.41 +- 4.67%, p = 0.028), which also had a relationship with the lymph node status.	Chloroform	32-35	CD8a molecule	Homo sapiens	27-30
26402444-7	2015	Patients with high-level CD8+ Tcm had a significantly higher median survival than those with low CD8+ Tcm (18 vs. 12 months, p = 0.004); a similar result was obtained in absolute CD8+ Tcm count.	Chloroform	30-33	CD8a molecule	Homo sapiens	25-28
25514132-6	2015	Chloroform and HAA represented, respectively, only 1-8% and 14-15% of adsorbable organic halides (AOX) by monochloramination but up to 29% and 39% of AOX by chlorination.	Chloroform	0-10	acyl-CoA oxidase 1	Homo sapiens	150-153
25300965-7	2014	After fractionation of MEC using various solvents such as chloroform, hexane, ethyl acetate and butanol, the mechanism of anti-inflammatory effect of chloroform extract (CEC) of MEC was evaluated since it showed maximum beneficial effect at a dose of 50 mg/kg BW Treatment of carrageenan-induced rats with CEC exerted significantly decreased COX-2, MPO, and NOS activities when compared to carrageenan-induced rats.	Chloroform	150-160	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	342-347
25502562-4	2014	This results from the surprising finding that RNase A remains functional in a phenol:chloroform mixture, to our knowledge the only enzyme that survives this highly denaturing solvent environment.	Chloroform	85-95	ribonuclease A family member 1, pancreatic	Homo sapiens	46-53
25502562-5	2014	Although RNase A does not cleave the DNA backbone it is capable of binding to DNA, forming stable RNase A-DNA complexes that partition to the interphase or organic phase during phenol:chloroform purification.	Chloroform	184-194	ribonuclease A family member 1, pancreatic	Homo sapiens	9-16
25502562-5	2014	Although RNase A does not cleave the DNA backbone it is capable of binding to DNA, forming stable RNase A-DNA complexes that partition to the interphase or organic phase during phenol:chloroform purification.	Chloroform	184-194	ribonuclease A family member 1, pancreatic	Homo sapiens	98-105
27024926-1	2015	Evaluation of effects caused by environmental peroral exposure to chlorine organic compounds revealed that individuals with AG variation of HTR2A gene are a community with increased sensitivity to chloroform and a risk group for lipid and carbohydrates metabolism disorders.	Chloroform	197-207	5-hydroxytryptamine receptor 2A	Homo sapiens	140-145
25234391-1	2014	In this work, we demonstrated insulin signaling and the anti-inflammatory effects by the chloroform fraction of ethanolic extract of Nymphaea rubra flowers in TNF-alpha-induced insulin resistance in the rat skeletal muscle cell line (L6 myotubes) to dissect out its anti-hyperglycemic mechanism.	Chloroform	89-99	tumor necrosis factor	Rattus norvegicus	159-168
25300965-7	2014	After fractionation of MEC using various solvents such as chloroform, hexane, ethyl acetate and butanol, the mechanism of anti-inflammatory effect of chloroform extract (CEC) of MEC was evaluated since it showed maximum beneficial effect at a dose of 50 mg/kg BW Treatment of carrageenan-induced rats with CEC exerted significantly decreased COX-2, MPO, and NOS activities when compared to carrageenan-induced rats.	Chloroform	150-160	myeloperoxidase	Rattus norvegicus	349-352
25026347-10	2014	The three fractions of chloroform extract showed significant effect, while F-2 being the most potent (51.02%).	Chloroform	23-33	coagulation factor II	Rattus norvegicus	75-78
25441150-5	2014	Among the 5 layers, the chloroform layer had the greatest inhibitory effect on LPS-stimulated nitric oxide production and inducible nitric oxide synthase mRNA expression in Raw 264.7 cells.	Chloroform	24-34	toll-like receptor 4	Mus musculus	79-82
25441150-7	2014	On the other hand, treatment of cells with the chloroform layer of A. arguta before LPS stimulation also reduced them RNA expression of proinflammatory cytokines including tumor necrosis factor alpha and interleukin 1beta.	Chloroform	47-57	toll-like receptor 4	Mus musculus	84-87
25441150-8	2014	Nuclear translocation of NF-kappaB p50 and p65 subunits induced by LPS was also inhibited by treatment with the chloroform layer of A. arguta.	Chloroform	112-122	toll-like receptor 4	Mus musculus	67-70
24903378-9	2014	In addition, chloroform extract had the ability to inhibit human P-glycoprotein-mediated daunorubicin in K562/R7 leukaemic cells in a dose-dependent manner compared to the positive control, cyclosporin A.	Chloroform	13-23	ATP binding cassette subfamily B member 1	Homo sapiens	65-79
25924408-2	2014	The dechlorination of CCl4 to dichloromethane (CH2Cl2) and chloroform (CHCl3) with a molar ratio of 3:2 was catalyzed by carbon-supported silver (Ag/C) catalyst in methanol solution.	Chloroform	59-69	C-C motif chemokine ligand 4	Homo sapiens	22-26
25924408-2	2014	The dechlorination of CCl4 to dichloromethane (CH2Cl2) and chloroform (CHCl3) with a molar ratio of 3:2 was catalyzed by carbon-supported silver (Ag/C) catalyst in methanol solution.	Chloroform	71-76	C-C motif chemokine ligand 4	Homo sapiens	22-26
25125194-5	2014	The yield of FAME obtained through EHMT of lipids in wet microalgae is comparable to that obtained through direct transesterification of dried microalgae biomass with chloroform; however, FAME content in crude biodiesel obtained through EHMT is 86.74%, while that in crude biodiesel obtained through the chloroform-based process is 75.93%.	Chloroform	167-177	benign adult familial myoclonic epilepsy 1	Homo sapiens	13-17
25125194-5	2014	The yield of FAME obtained through EHMT of lipids in wet microalgae is comparable to that obtained through direct transesterification of dried microalgae biomass with chloroform; however, FAME content in crude biodiesel obtained through EHMT is 86.74%, while that in crude biodiesel obtained through the chloroform-based process is 75.93%.	Chloroform	304-314	benign adult familial myoclonic epilepsy 1	Homo sapiens	13-17
25171168-5	2014	Dual fluorescence was observed for the dimethylamino-substituted BF2 complex in toluene, 1,4-dioxane, and chloroform, corresponding to locally excited (LE) and twisted intramolecular charge-transfer (TICT) states.	Chloroform	106-116	forkhead box G1	Homo sapiens	65-68
25161521-1	2014	The title compound, [RuCl2(eta(6)-C6H6)(C12H22ClP)] CHCl3, was prepared by reaction of [RuCl2(eta(6)-C6H6)]2 with chloro-dicyclo-hexyl-phosphane in CHCl3 at 323 K under argon.	Chloroform	52-57	endothelin receptor type A	Homo sapiens	27-30
24999828-1	2014	In a screening of extracts of selected plants native to Ohio against the human bitterness receptor hTAS2R31, a chloroform-soluble extract of the aerial parts of Solidago canadensis (Canada goldenrod) was determined to have hTAS2R31 antagonistic activity and, thus, was fractionated for isolation of potential bitterness-masking agents.	Chloroform	111-121	taste 2 receptor member 31	Homo sapiens	99-107
24999828-1	2014	In a screening of extracts of selected plants native to Ohio against the human bitterness receptor hTAS2R31, a chloroform-soluble extract of the aerial parts of Solidago canadensis (Canada goldenrod) was determined to have hTAS2R31 antagonistic activity and, thus, was fractionated for isolation of potential bitterness-masking agents.	Chloroform	111-121	taste 2 receptor member 31	Homo sapiens	223-231
25001225-3	2014	By high-performance liquid chromatography (HPLC), we found that A2E and ATR-dimer were both altered by tetrahydrofuran (THF) and chloroform, but were stable in dimethyl sulfoxide (DMSO) or methanol (MeOH).	Chloroform	129-139	ATR serine/threonine kinase	Homo sapiens	72-75
25161521-1	2014	The title compound, [RuCl2(eta(6)-C6H6)(C12H22ClP)] CHCl3, was prepared by reaction of [RuCl2(eta(6)-C6H6)]2 with chloro-dicyclo-hexyl-phosphane in CHCl3 at 323 K under argon.	Chloroform	52-57	endothelin receptor type A	Homo sapiens	94-97
24446274-2	2014	Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting.	Chloroform	96-106	phospholipase C like 1 (inactive)	Homo sapiens	33-37
24402080-4	2014	Single channel recording via patch clamping showed that the TREK-1 outward currents in astrocytes could be activated by arachidonic acid (AA) or chloroform with the conductance of 113 +- 14 and 120 +- 13 pS, respectively.	Chloroform	145-155	potassium two pore domain channel subfamily K member 2	Rattus norvegicus	60-66
24684587-5	2014	By mixing solvents of varying spreading coefficients and evaporation rates, such as chloroform and chlorobenzene, MEH-PPV can be assembled into micrometer-sized ring structures.	Chloroform	84-94	epoxide hydrolase 1	Homo sapiens	114-117
24607130-3	2014	Among CH2Cl2, CHCl3 and CCl4, CCl4 was chosen as the modifier due to the best peak-to-peak resolution and stability towards the fluctuation of modifier concentration.	Chloroform	14-19	C-C motif chemokine ligand 4	Homo sapiens	30-34
24689807-6	2014	The propensity for methanol"s self-association in the solvents studied increases in the order: CH2Cl2 ~ CHCl3 &lt; C6H6 &lt; CCl4.	Chloroform	104-109	C-C motif chemokine ligand 4	Homo sapiens	125-129
24949447-2	2014	Chloroform, dichloromethane, and toluene are primarily metabolized in liver by CYP2E1, producing reactive electrophilic metabolites, and may also produce oxidative stress via the uncoupled CYP2E1 catalytic cycle.	Chloroform	0-10	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	79-85
24479629-6	2014	The AChE inhibitory activity of leaves and stem chloroform extracts and kaempferol were 80%, 93% and 85.8%, respectively.	Chloroform	48-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-8
24479629-11	2014	In conclusion, the inhibition of AChE by leaf and stem chloroform extracts of A. subintegra could be due to the presence of kaempferol.	Chloroform	55-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	33-37
24389872-8	2014	Moreover, phospho-Thr(172)-AMPK levels greatly increased upon PKC activation induced by PMA, and the PKC inhibitor Ro-32-0432 inhibits TCM-induced AMPK activation.	Chloroform	135-138	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	27-31
24389872-8	2014	Moreover, phospho-Thr(172)-AMPK levels greatly increased upon PKC activation induced by PMA, and the PKC inhibitor Ro-32-0432 inhibits TCM-induced AMPK activation.	Chloroform	135-138	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	147-151
24949447-2	2014	Chloroform, dichloromethane, and toluene are primarily metabolized in liver by CYP2E1, producing reactive electrophilic metabolites, and may also produce oxidative stress via the uncoupled CYP2E1 catalytic cycle.	Chloroform	0-10	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	189-195
24215354-13	2013	Meanwhile, eighteen fractions (RC1-RC18) were obtained after purification of the rhizome chloroform extract, of which fraction RC5 showed cytotoxicity against SKOV-3 cells with high selectivity index.	Chloroform	89-99	chromobox 8	Homo sapiens	31-34
24160998-0	2013	A mixed quantum-classical molecular dynamics study of anti-tetrol and syn-tetrol dissolved in liquid chloroform II: infrared emission spectra, vibrational excited-state lifetimes, and nonequilibrium hydrogen-bond dynamics.	Chloroform	101-114	synemin	Homo sapiens	70-73
25852760-6	2014	RESULTS: beta-actin-positive was detected in 279/330 (84%) and 272/304 (89%) samples by phenol-chloroform technique and salting-out, respectively.	Chloroform	95-105	POTE ankyrin domain family member F	Homo sapiens	9-19
24106805-2	2013	The present constant-pH MD study of the acylated and deacylated isoforms of SP-C in a chloroform/methanol/water mixture, often used to mimic the membrane environment, shows that the loss of the acyl groups has a structural destabilizing effect and that the increase of pH promotes intraprotein contacts which contribute to the loss of helical structure in solution.	Chloroform	86-96	surfactant protein C	Homo sapiens	76-80