PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8668188-0	1996	Site-specific excision repair of 1-nitrosopyrene-induced DNA adducts at the nucleotide level in the HPRT gene of human fibroblasts: effect of adduct conformation on the pattern of site-specific repair.	1-nitrosopyrene	33-48	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	100-104
7592980-2	1995	We tested this by measuring the rate of excision repair of guanine adducts formed in the HPRT gene of diploid human fibroblasts and in the overall genome by two structurally related polycyclic carcinogens, 1-nitrosopyrene (1-NOP) and N-acetoxy-2-acetylaminofluorene (N-AcO-AAF) and comparing the results with those we found previously using benzo[a]pyrene diol epoxide (BPDE).	1-nitrosopyrene	206-221	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	89-93
1586993-0	1992	DNA sequence analysis of 1-nitrosopyrene-induced mutations in the hprt gene of Chinese hamster ovary cells.	1-nitrosopyrene	25-40	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	66-70
8033153-0	1994	Kinds and locations of mutations induced in the hypoxanthine-guanine phosphoribosyltransferase gene of human T-lymphocytes by 1-nitrosopyrene, including those caused by V(D)J recombinase.	1-nitrosopyrene	126-141	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	48-94
8033153-2	1994	We exposed adult human T-cells in vitro to 1-nitrosopyrene (1-NOP), a partially reduced metabolite of 1-nitropyrene, a ubiquitous environmental carcinogen.	1-nitrosopyrene	43-58	prepronociceptin	Homo sapiens	62-65
1586993-1	1992	DNA sequence was determined in 21 mutants induced at the hprt locus of Chinese hamster ovary (CHO) cells by 1-nitrosopyrene, a metabolite of the tumorigenic environmental pollutant 1-nitropyrene.	1-nitrosopyrene	108-123	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	57-61
1586993-8	1992	The results indicate a specificity for the induction of mutations in the hprt gene of CHO cells by 1-nitrosopyrene with respect to both the types of mutations produced and their location in the hprt gene.	1-nitrosopyrene	99-114	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	73-77
1586993-8	1992	The results indicate a specificity for the induction of mutations in the hprt gene of CHO cells by 1-nitrosopyrene with respect to both the types of mutations produced and their location in the hprt gene.	1-nitrosopyrene	99-114	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	194-198
3062380-7	1988	USA 84:3787-3791, 1987), we treated a shuttle vector with tritiated 1-nitrosopyrene (1-NOP), a carcinogenic mutagenic intermediate metabolite of 1-nitropyrene which forms the same DNA adduct as the parent compound, and introduced the plasmids into a human embryonic kidney cell line, 293, for DNA replication to take place.	1-nitrosopyrene	68-83	prepronociceptin	Homo sapiens	87-90
1541256-1	1992	1-Nitrosopyrene, a metabolite of the tumorigenic environmental pollutant 1-nitropyrene, is a potent mutagen at the hprt locus in Chinese hamster ovary (CHO) cells.	1-nitrosopyrene	0-15	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	115-119
1541256-7	1992	Using polymerase chain reaction amplification of cDNA synthesized from RNA, the hprt protein-coding region could be amplified from 23 of the 1-nitrosopyrene-induced mutants and 11 of the control mutants.	1-nitrosopyrene	141-156	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	80-84
1541256-10	1992	A large number of both control and 1-nitrosopyrene-induced mutants exhibited a marked reduction in hprt mRNA concentration or possessed truncated mRNA hprt protein coding sequence.	1-nitrosopyrene	35-50	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	99-103
1541256-10	1992	A large number of both control and 1-nitrosopyrene-induced mutants exhibited a marked reduction in hprt mRNA concentration or possessed truncated mRNA hprt protein coding sequence.	1-nitrosopyrene	35-50	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	151-155
3943146-1	1986	The cytotoxic and mutagenic effects of 1-nitropyrene (1-NP) and its reduced metabolite 1-nitrosopyrene (1-NOP) were determined in diploid human fibroblasts.	1-nitrosopyrene	87-102	prepronociceptin	Homo sapiens	106-109
3269256-4	1988	For example, 1-nitropyrene (1-NP) is activated by enzymatic reduction to 1-nitrosopyrene (1-NOP), followed by reduction to the hydroxylamine, which undergoes decomposition to yield a nitrenium ion, that reacts with DNA.	1-nitrosopyrene	73-88	prepronociceptin	Homo sapiens	92-95