PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31316818-0 2019 Supramolecular synthon hierarchy in sulfonamide cocrystals with syn-amides and N-oxides. n-oxides 79-87 synemin Homo sapiens 15-18 30282042-5 2018 Therefore, we examined the effects and mechanisms of strychnine and brucine, two main ingredients of Nux vomica, and their N-oxides on hERG channels. n-oxides 123-131 ETS transcription factor ERG Homo sapiens 135-139 29377789-1 2018 1,2-Dehydro-pyrrolizidine alkaloids (PA) and their N-oxides (PANO) exhibit acute and chronic toxic effects on the liver and other organs and therefore are a hazard for animal and human health. n-oxides 51-59 proapoptotic nucleolar protein 1 Homo sapiens 61-65 29856598-7 2018 The enzyme has been found to exist in two isoforms, mARC1 and mARC2, both being capable of reducing a variety of N-oxygenated compounds, including nonphysiological N-oxides. n-oxides 164-172 mitochondrial amidoxime reducing component 2 Mus musculus 52-57 29856598-7 2018 The enzyme has been found to exist in two isoforms, mARC1 and mARC2, both being capable of reducing a variety of N-oxygenated compounds, including nonphysiological N-oxides. n-oxides 164-172 mitochondrial amidoxime reducing component 2 Mus musculus 62-67 29977388-3 2018 These new transformations displayed complete regioselectivity for the C-6 position of bipyridinones and the C-8 position of quinoline N-oxides and tolerated a broad range of functionalities, such as halogens, ethers, or trifluoromethyl groups. n-oxides 134-142 homeobox C8 Homo sapiens 108-111 28888950-3 2017 AOX is also reported to catalyze the reductive metabolism of nitro-compounds, N-oxides, sulfoxides, isoxazoles, isothiazoles, nitrite and hydroxamic acids. n-oxides 78-86 aldehyde oxidase 1 Homo sapiens 0-3 29126730-10 2018 Compared with the fluoroethyl derivative 1a, the carbazole N-atom of the fluoroisopropyl derivative 13a (Ki(CB2) = 2.9 nM) is better shielded against the attack of CYP enzymes as formation of N-oxides was not observed and N-dealkylation took place to a less amount. n-oxides 192-200 cannabinoid receptor 2 (macrophage) Mus musculus 108-111 28952306-3 2017 The key intramolecular O-arylation reaction was achieved by nucleophilic attack of enolates to C2 of N-oxides under PyBrop or Ac2O activation conditions. n-oxides 101-109 adenylate cyclase 2 Homo sapiens 126-129 12189042-10 2002 However, oxygenated myoglobin readily reacts with *NO to yield higher order N-oxides such as nitrate, while both the ferrous and ferric forms of the protein form a stable complex with *NO. n-oxides 76-84 myoglobin Homo sapiens 20-29 27853934-8 2017 RESULTS: N-oxides of clozapine (CYP2B6/2C19) and voriconazole (CYP2C9/3A4) showed CYP inhibition >=50%. n-oxides 9-17 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 32-38 27853934-8 2017 RESULTS: N-oxides of clozapine (CYP2B6/2C19) and voriconazole (CYP2C9/3A4) showed CYP inhibition >=50%. n-oxides 9-17 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 63-69 25690669-7 2015 The results of this research demonstrate the utility of the heterozygous p53 knockout mouse model for further investigation of comparative carcinogenesis of structurally and toxicologically different DHPAs and their N-oxides. n-oxides 216-224 transformation related protein 53, pseudogene Mus musculus 73-76 26002730-6 2015 CYP enzymes utilize hydroperoxides, peracids, perborate, percarbonate, periodate, chlorite, iodosobenzene and N-oxides as surrogate oxygen atom donors to oxygenate substrates via the shunt pathway in the absence of NAD(P)H/O2 and reduction-oxidation (redox) auxiliary proteins. n-oxides 110-118 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 22390194-4 2012 The N-oxides 1, 5, and 6 have closed-shell singlet ground states and low-lying, singlet biradical (SP-1, SP-6) or biradicaloid (SP-5) excited states. n-oxides 4-12 Sp1 transcription factor Homo sapiens 99-109 21859103-6 2011 Finally, one of the N-oxides showed potent ability to inhibit the enzymatic function of NQO2 in cells, and therefore, it may be useful as a pharmacological probe to study the properties of the enzyme in vitro and in vivo. n-oxides 20-28 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 88-92 27471846-0 2016 N-Oxides rescue Ru(v) in catalytic Griffith-Ley (TPAP) alcohol oxidations. n-oxides 0-8 poly(A) polymerase beta Homo sapiens 49-53 25316345-2 2014 Introducing the N-oxides into the azacubanes could improve their detonation performance significantly due to the increase of the OB and rho but would also increase the sensitivity to some extent. n-oxides 16-24 rhodopsin Homo sapiens 129-139 25045021-0 2014 The mitochondrial amidoxime reducing component (mARC): involvement in metabolic reduction of N-oxides, oximes and N-hydroxyamidinohydrazones. n-oxides 93-101 activity regulated cytoskeletal-associated protein Mus musculus 48-52 25045021-2 2014 In this study, we tested the involvement of mARC in the reduction of N-oxides (amitriptyline-N-oxide, nicotinamide-N-oxide), oximes ((E)-/(Z)-2,4,6-trimethylacetophenonoxime) and a N-hydroxyamidinohydrazone (guanoxabenz). n-oxides 69-77 activity regulated cytoskeletal-associated protein Mus musculus 44-48 25045021-6 2014 However, differences in the reduction of oximes and N-oxides between the two isoforms, namely mARC1 and mARC2, were detectable; N-oxides are exclusively reduced by mARC1. n-oxides 52-60 mitochondrial amidoxime reducing component 2 Mus musculus 94-99 25045021-6 2014 However, differences in the reduction of oximes and N-oxides between the two isoforms, namely mARC1 and mARC2, were detectable; N-oxides are exclusively reduced by mARC1. n-oxides 52-60 mitochondrial amidoxime reducing component 2 Mus musculus 104-109 25045021-6 2014 However, differences in the reduction of oximes and N-oxides between the two isoforms, namely mARC1 and mARC2, were detectable; N-oxides are exclusively reduced by mARC1. n-oxides 52-60 mitochondrial amidoxime reducing component 2 Mus musculus 164-169 25045021-6 2014 However, differences in the reduction of oximes and N-oxides between the two isoforms, namely mARC1 and mARC2, were detectable; N-oxides are exclusively reduced by mARC1. n-oxides 128-136 mitochondrial amidoxime reducing component 2 Mus musculus 94-99 25045021-6 2014 However, differences in the reduction of oximes and N-oxides between the two isoforms, namely mARC1 and mARC2, were detectable; N-oxides are exclusively reduced by mARC1. n-oxides 128-136 mitochondrial amidoxime reducing component 2 Mus musculus 104-109 25045021-6 2014 However, differences in the reduction of oximes and N-oxides between the two isoforms, namely mARC1 and mARC2, were detectable; N-oxides are exclusively reduced by mARC1. n-oxides 128-136 mitochondrial amidoxime reducing component 2 Mus musculus 164-169 19839404-0 2007 Studies in 3,4-diaryl-1,2,5-oxadiazoles and their N-oxides: search for better COX-2 inhibitors. n-oxides 50-58 cytochrome c oxidase II, mitochondrial Rattus norvegicus 78-83 11334263-0 2001 Non-enzymatic reduction of aliphatic tertiary amine N-oxides mediated by the haem moiety of cytochrome P450. n-oxides 52-60 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 92-107 11522254-0 2001 Quinolones and their N-oxides as inhibitors of photosystem II and the cytochrome b(6)/f-complex. n-oxides 21-29 mitochondrially encoded cytochrome b Homo sapiens 70-82 11334263-2 2001 The mechanism of reduction of aliphatic tertiary amine N-oxides to tertiary amines in liver microsomes was examined and a novel type of reduction by cytochrome P450 was found. n-oxides 55-63 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 149-164 8486725-6 1993 In the presence of NADPH and NADPH-P450 reductase some reduction to N,N-dialkylamines occurred, along with N-dealkylation (to monoalkylanilines); there was also slow N-dealkylation in the absence of NADPH, which is interpreted in terms of homolytic scission of the N-O bond; N,N-dialkylanilines were not formed nor did the N-oxides support other oxygenation reactions. n-oxides 323-331 2,4-dienoyl-CoA reductase 1 Homo sapiens 19-24 10834270-5 1999 Both the N-oxides and the corresponding amines were more cytotoxic to an ERCC-1 mutant defective in nucleotide excision repair, indicating that DNA alkylation was the cytotoxic event. n-oxides 9-17 DNA excision repair protein ERCC-1 Cricetulus griseus 73-79 8826101-8 1995 In a sequela, TNF released by T cells seems to induce an excess synthesis of N-oxides which appear to be the final morbific agent. n-oxides 77-85 tumor necrosis factor Homo sapiens 14-17 8763844-3 1996 This study compares three intercalator N-oxides (NC-NO, DACA-NO and AQ4N), which, respectively, give nitracrine (NC), DACA and AQ4 on reduction. n-oxides 39-47 immunoglobulin kappa chain variable 4-61 Mus musculus 68-71 8597120-4 1995 The brain microsomal and mitochondrial P450 systems are capable of metabolizing a variety of xenobiotics, while the brain FMO efficiently metabolizes a variety of psychoactive drugs to their respective N-oxides. n-oxides 202-210 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 39-43 8486725-6 1993 In the presence of NADPH and NADPH-P450 reductase some reduction to N,N-dialkylamines occurred, along with N-dealkylation (to monoalkylanilines); there was also slow N-dealkylation in the absence of NADPH, which is interpreted in terms of homolytic scission of the N-O bond; N,N-dialkylanilines were not formed nor did the N-oxides support other oxygenation reactions. n-oxides 323-331 2,4-dienoyl-CoA reductase 1 Homo sapiens 29-34 8486725-6 1993 In the presence of NADPH and NADPH-P450 reductase some reduction to N,N-dialkylamines occurred, along with N-dealkylation (to monoalkylanilines); there was also slow N-dealkylation in the absence of NADPH, which is interpreted in terms of homolytic scission of the N-O bond; N,N-dialkylanilines were not formed nor did the N-oxides support other oxygenation reactions. n-oxides 323-331 2,4-dienoyl-CoA reductase 1 Homo sapiens 29-34 8486725-7 1993 P450 2B1 (with its reductase and NADPH) formed N-oxides at low rates from several N,N-dialkylaniline derivatives, including N,N-dimethylaniline, N,N-diethylaniline, N-ethyl-N-methylaniline, 4-methyl-N,N-dimethylaniline, 4-cyano-N,N-dimethylaniline, N-phenylpyrrolidine, and N,N-dimethyl-2-aminofluorene. n-oxides 47-55 2,4-dienoyl-CoA reductase 1 Homo sapiens 33-38 3397989-2 1988 The C-9 and C-7 monoesters and C-7, C-9 diesters of heliotridine with (S)-(+) and (R)-(-)-2-hydroxy-2-phenylbutyric acid were prepared, converted into their N-oxides, and compared with the corresponding C-9 monoesters of retronecine in the in vivo P388 lymphocytic leukemia screen. n-oxides 157-165 complement C9 Homo sapiens 4-7 1488451-6 1992 Thus the aromatic heterocycle yields three N-oxides (M-4, M-5, M-7). n-oxides 43-51 cholinergic receptor, muscarinic 4 Rattus norvegicus 53-56 35137743-0 2022 N-Oxides amplify catalyst reactivity and isoselectivity in the ring-opening polymerization of rac-beta-butyrolactone. n-oxides 0-8 AKT serine/threonine kinase 2 Homo sapiens 94-102 35137743-1 2022 N-Oxides can amplify the performance of a lanthanum aminobisphenolate catalyst in the ring-opening polymerization (ROP) of rac-beta-butyrolactone (rac-BBL) to unprecedented levels (TOF/Pm; At RT: 1900 h-1/0.73, At -30 C: 200 h-1/0.82). n-oxides 0-8 AKT serine/threonine kinase 2 Homo sapiens 123-131 35137743-1 2022 N-Oxides can amplify the performance of a lanthanum aminobisphenolate catalyst in the ring-opening polymerization (ROP) of rac-beta-butyrolactone (rac-BBL) to unprecedented levels (TOF/Pm; At RT: 1900 h-1/0.73, At -30 C: 200 h-1/0.82). n-oxides 0-8 FEZ family zinc finger 2 Homo sapiens 181-184 3397989-2 1988 The C-9 and C-7 monoesters and C-7, C-9 diesters of heliotridine with (S)-(+) and (R)-(-)-2-hydroxy-2-phenylbutyric acid were prepared, converted into their N-oxides, and compared with the corresponding C-9 monoesters of retronecine in the in vivo P388 lymphocytic leukemia screen. n-oxides 157-165 complement C7 Homo sapiens 31-34 7115339-8 1982 The ability of forming low-spin adducts with ferrous cytochrome P-450 absorbing around 440 nm appears to be an inherent property of different types of N-oxides. n-oxides 151-159 cytochrome P-450 Oryctolagus cuniculus 53-69 33228195-0 2020 Aerobic Cytotoxicity of Aromatic N-Oxides: The Role of NAD(P)H:Quinone Oxidoreductase (NQO1). n-oxides 33-41 crystallin zeta Homo sapiens 63-85 33228195-0 2020 Aerobic Cytotoxicity of Aromatic N-Oxides: The Role of NAD(P)H:Quinone Oxidoreductase (NQO1). n-oxides 33-41 NAD(P)H quinone dehydrogenase 1 Homo sapiens 87-91 33228195-8 2020 These data demonstrate that NQO1 is a potentially important target of action of heteroaromatic N-oxides. n-oxides 95-103 NAD(P)H quinone dehydrogenase 1 Homo sapiens 28-32 32121600-1 2020 Pyrrolizidine alkaloids (PA) and their N-oxides (PANO) are a group of toxic secondary plant metabolites occurring predominantly as contaminants in (herbal) teas, honeys and food supplements, as well as in spices and culinary herbs. n-oxides 39-47 proapoptotic nucleolar protein 1 Homo sapiens 49-53 28473-0 1978 Reduction of tertiary amine N-oxides by cytochrome P-450. n-oxides 28-36 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-56