PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28856713-2	2018	Although both exercise (ie, mechanical stimulation) and branched-chain amino acid leucine supplementation have been reported to stimulate muscle protein synthesis by activating the mammalian target of rapamycin (mTOR) signaling pathway independently, the mechanisms underlying their synergistic effects are largely unknown.	branched-chain amino acid leucine	56-89	mechanistic target of rapamycin kinase	Homo sapiens	181-210
29617841-7	2018	Other components of alpha-lactalbumin that may have usefulness in nutritional supplements include the branched-chain amino acid leucine, which promotes protein accretion in skeletal muscle, and bioactive peptides, which possess prebiotic and antibacterial properties.	branched-chain amino acid leucine	102-135	lactalbumin alpha	Homo sapiens	20-37
28856713-2	2018	Although both exercise (ie, mechanical stimulation) and branched-chain amino acid leucine supplementation have been reported to stimulate muscle protein synthesis by activating the mammalian target of rapamycin (mTOR) signaling pathway independently, the mechanisms underlying their synergistic effects are largely unknown.	branched-chain amino acid leucine	56-89	mechanistic target of rapamycin kinase	Homo sapiens	212-216
18716165-6	2008	In comparison, the branched-chain amino acid leucine (Leu) activated pp70(s6k), was a weaker stimulator of migration (23% coverage), and did not increase NO.	branched-chain amino acid leucine	19-52	ribosomal protein S6 kinase B1	Rattus norvegicus	74-77
23129808-2	2013	The branched-chain amino acid leucine is an essential nutrient that stimulates mTORC1 to promote protein synthesis by activating p70 S6 kinase 1 (S6K1).	branched-chain amino acid leucine	4-37	CREB regulated transcription coactivator 1	Mus musculus	79-85
23129808-2	2013	The branched-chain amino acid leucine is an essential nutrient that stimulates mTORC1 to promote protein synthesis by activating p70 S6 kinase 1 (S6K1).	branched-chain amino acid leucine	4-37	ribosomal protein S6 kinase B1	Homo sapiens	133-144
23129808-2	2013	The branched-chain amino acid leucine is an essential nutrient that stimulates mTORC1 to promote protein synthesis by activating p70 S6 kinase 1 (S6K1).	branched-chain amino acid leucine	4-37	ribosomal protein S6 kinase B1	Homo sapiens	146-150
22354780-6	2012	The branched-chain amino acid leucine is critical for muscle growth and acts in part through activation of mTORC1.	branched-chain amino acid leucine	4-37	CREB regulated transcription coactivator 1	Mus musculus	107-113
21791619-1	2011	The branched-chain amino acid leucine stimulates muscle protein synthesis in part by directly activating the mTOR signaling pathway.	branched-chain amino acid leucine	4-37	mechanistic target of rapamycin kinase	Rattus norvegicus	109-113
19266162-2	2009	We tested the hypothesis that the branched-chain amino acid leucine reduces acute insulin action in primary myotubes via a negative feedback mechanism involving ribosomal protein S6 kinase 1 (S6K1).	branched-chain amino acid leucine	34-67	insulin	Homo sapiens	82-89
19266162-2	2009	We tested the hypothesis that the branched-chain amino acid leucine reduces acute insulin action in primary myotubes via a negative feedback mechanism involving ribosomal protein S6 kinase 1 (S6K1).	branched-chain amino acid leucine	34-67	ribosomal protein S6 kinase B1	Homo sapiens	192-196
15640518-3	2004	We have proposed that the branched-chain amino acid leucine is a key to the metabolic advantage of a higher protein diet because of its unique roles in regulation of muscle protein synthesis, insulin signaling and glucose re-cycling via alanine.	branched-chain amino acid leucine	26-59	insulin	Homo sapiens	192-199
16581023-1	2006	Branched-chain amino acid leucine has been shown to activate the translational regulators through the mammalian target of rapamycin.	branched-chain amino acid leucine	0-33	mechanistic target of rapamycin kinase	Homo sapiens	102-131
15228219-1	2004	The indispensable branched-chain amino acid leucine acts as a key regulator of mRNA translation by modulating the phosphorylation of proteins that represent important control points in translation initiation, including the translational repressor, eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (S6K1).	branched-chain amino acid leucine	18-51	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	248-303
15228219-1	2004	The indispensable branched-chain amino acid leucine acts as a key regulator of mRNA translation by modulating the phosphorylation of proteins that represent important control points in translation initiation, including the translational repressor, eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (S6K1).	branched-chain amino acid leucine	18-51	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	305-311
15228219-1	2004	The indispensable branched-chain amino acid leucine acts as a key regulator of mRNA translation by modulating the phosphorylation of proteins that represent important control points in translation initiation, including the translational repressor, eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (S6K1).	branched-chain amino acid leucine	18-51	ribosomal protein S6 kinase B1	Homo sapiens	346-351
12351422-5	2002	Recently, the ability of nutrients, in particular the branched-chain amino acid leucine, to activate mTOR independent of insulin by a process designated as nutrient signaling has been identified.	branched-chain amino acid leucine	54-87	mechanistic target of rapamycin kinase	Homo sapiens	101-105
12351422-5	2002	Recently, the ability of nutrients, in particular the branched-chain amino acid leucine, to activate mTOR independent of insulin by a process designated as nutrient signaling has been identified.	branched-chain amino acid leucine	54-87	insulin	Homo sapiens	121-128
11272147-1	2001	Recent findings have demonstrated that the branched-chain amino acid leucine can activate the translational regulators, phosphorylated heat- and acid-stable protein regulated by insulin (PHAS-I) and p70 S6 kinase (p70S6k), in an insulin-independent and rapamycin-sensitive manner through mammalian target of rapamycin (mTOR), although the mechanism for this activation is undefined.	branched-chain amino acid leucine	43-76	insulin	Homo sapiens	178-185
11272147-1	2001	Recent findings have demonstrated that the branched-chain amino acid leucine can activate the translational regulators, phosphorylated heat- and acid-stable protein regulated by insulin (PHAS-I) and p70 S6 kinase (p70S6k), in an insulin-independent and rapamycin-sensitive manner through mammalian target of rapamycin (mTOR), although the mechanism for this activation is undefined.	branched-chain amino acid leucine	43-76	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	187-193
11272147-1	2001	Recent findings have demonstrated that the branched-chain amino acid leucine can activate the translational regulators, phosphorylated heat- and acid-stable protein regulated by insulin (PHAS-I) and p70 S6 kinase (p70S6k), in an insulin-independent and rapamycin-sensitive manner through mammalian target of rapamycin (mTOR), although the mechanism for this activation is undefined.	branched-chain amino acid leucine	43-76	ribosomal protein S6 kinase B1	Homo sapiens	199-212
11272147-1	2001	Recent findings have demonstrated that the branched-chain amino acid leucine can activate the translational regulators, phosphorylated heat- and acid-stable protein regulated by insulin (PHAS-I) and p70 S6 kinase (p70S6k), in an insulin-independent and rapamycin-sensitive manner through mammalian target of rapamycin (mTOR), although the mechanism for this activation is undefined.	branched-chain amino acid leucine	43-76	ribosomal protein S6 kinase B1	Homo sapiens	214-220
11272147-1	2001	Recent findings have demonstrated that the branched-chain amino acid leucine can activate the translational regulators, phosphorylated heat- and acid-stable protein regulated by insulin (PHAS-I) and p70 S6 kinase (p70S6k), in an insulin-independent and rapamycin-sensitive manner through mammalian target of rapamycin (mTOR), although the mechanism for this activation is undefined.	branched-chain amino acid leucine	43-76	insulin	Homo sapiens	229-236
11272147-1	2001	Recent findings have demonstrated that the branched-chain amino acid leucine can activate the translational regulators, phosphorylated heat- and acid-stable protein regulated by insulin (PHAS-I) and p70 S6 kinase (p70S6k), in an insulin-independent and rapamycin-sensitive manner through mammalian target of rapamycin (mTOR), although the mechanism for this activation is undefined.	branched-chain amino acid leucine	43-76	mechanistic target of rapamycin kinase	Homo sapiens	288-317
11272147-1	2001	Recent findings have demonstrated that the branched-chain amino acid leucine can activate the translational regulators, phosphorylated heat- and acid-stable protein regulated by insulin (PHAS-I) and p70 S6 kinase (p70S6k), in an insulin-independent and rapamycin-sensitive manner through mammalian target of rapamycin (mTOR), although the mechanism for this activation is undefined.	branched-chain amino acid leucine	43-76	mechanistic target of rapamycin kinase	Homo sapiens	319-323