PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35470784-1	2022	Human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR; EC 1.1.1.34) catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, which has been defined as the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus playing a critical role in cellular cholesterol homeostasis.	3-hydroxy-3-methylglutaryl-coenzyme A	103-136	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	6-53
8621648-2	1996	The enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyzes the conversion of 3-hydroxy-3-methylglutaryl-CoA to mevalonic acid, considered the rate-limiting step in isoprenoid biosynthesis.	3-hydroxy-3-methylglutaryl-coenzyme A	11-41	3-hydroxy-3-methylglutaryl-coenzyme A reductase 1	Solanum lycopersicum	53-57
8095409-1	1993	(S)-(3-Hydroxy-3-methyl-1-thionoglutaryl)-Coenzyme A (HMG[= S]CoA), a dithioester analog of (S)-(3-hydroxy-3-methylglutaryl)-CoA (HMG-CoA), acts as an efficient alternative substrate for avian HMG-CoA lyase.	3-hydroxy-3-methylglutaryl-coenzyme A	92-128	3-hydroxy-3-methylglutaryl-CoA lyase	Homo sapiens	193-206
1466790-1	1992	Stereochemically pure samples of enzymically active (3S)-3-hydroxy-3-methylglutaryl-CoA and its enzymically inactive R diastereomer were prepared in good yield with a genetically engineered catalytic fragment of human 3-hydroxy-3-methylglutaryl-CoA reductase.	3-hydroxy-3-methylglutaryl-coenzyme A	52-87	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	218-258
35470784-1	2022	Human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR; EC 1.1.1.34) catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, which has been defined as the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus playing a critical role in cellular cholesterol homeostasis.	3-hydroxy-3-methylglutaryl-coenzyme A	103-136	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	55-60
35470784-1	2022	Human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR; EC 1.1.1.34) catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, which has been defined as the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus playing a critical role in cellular cholesterol homeostasis.	3-hydroxy-3-methylglutaryl-coenzyme A	138-145	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	6-53
35470784-1	2022	Human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR; EC 1.1.1.34) catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, which has been defined as the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus playing a critical role in cellular cholesterol homeostasis.	3-hydroxy-3-methylglutaryl-coenzyme A	138-145	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	55-60
34975302-10	2022	In addition, L-NAME and AMPK inhibitor repressed the MPE-induced total and phosphorylated 3-hydroxy-3-methylglutaryl coenzyme A (HMG-Co A) level.	3-hydroxy-3-methylglutaryl-coenzyme A	90-127	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	24-28
34975302-10	2022	In addition, L-NAME and AMPK inhibitor repressed the MPE-induced total and phosphorylated 3-hydroxy-3-methylglutaryl coenzyme A (HMG-Co A) level.	3-hydroxy-3-methylglutaryl-coenzyme A	129-137	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	24-28
31712757-6	2019	First, HISE1 downregulates the protein levels of the beta-hydroxy beta-methylglutaryl-CoA reductases HMGR1 and HMGR2, which are rate-limiting enzymes in the sterol synthesis pathway, resulting in suppression of sterol overproduction.	3-hydroxy-3-methylglutaryl-coenzyme A	53-89	hydroxy methylglutaryl CoA reductase 1	Arabidopsis thaliana	101-106
6860631-1	1983	3-Hydroxy-3-methylglutaryl-CoA lyase, which performs the cleavage of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to acetoacetate and acetyl-CoA by a Claisen-type reaction, also catalyzes enolization of acetyl-CoA.	3-hydroxy-3-methylglutaryl-coenzyme A	101-108	3-hydroxy-3-methylglutaryl-CoA lyase	Homo sapiens	0-36
33872413-3	2021	In-silico results revealed that SR-5, SR-8, SR-9 and SR-10 exhibited high affinity with 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) possessing binding energy values of -8.2, -8.4, -8.6 and -9.5 Kcal/mol respectively and moderate (< -8 Kcal/mol) against other selected targets.	3-hydroxy-3-methylglutaryl-coenzyme A	88-125	Stress response QTL 5	Rattus norvegicus	32-36
33872413-3	2021	In-silico results revealed that SR-5, SR-8, SR-9 and SR-10 exhibited high affinity with 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) possessing binding energy values of -8.2, -8.4, -8.6 and -9.5 Kcal/mol respectively and moderate (< -8 Kcal/mol) against other selected targets.	3-hydroxy-3-methylglutaryl-coenzyme A	127-133	Stress response QTL 5	Rattus norvegicus	32-36
32905056-1	2020	Mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG Co-A) synthase (mHS) deficiency is an autosomal recessive disorder of ketone body synthesis which has traditionally been associated with hypoketotic hypoglycemia, hepatomegaly and encephalopathy, presenting in early childhood following a period of fasting.	3-hydroxy-3-methylglutaryl-coenzyme A	14-44	Coenzyme A synthase	Homo sapiens	50-64
32905056-1	2020	Mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG Co-A) synthase (mHS) deficiency is an autosomal recessive disorder of ketone body synthesis which has traditionally been associated with hypoketotic hypoglycemia, hepatomegaly and encephalopathy, presenting in early childhood following a period of fasting.	3-hydroxy-3-methylglutaryl-coenzyme A	14-44	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Mus musculus	66-69
32004772-1	2020	Fluvastatin and atorvastatin are inhibitors of hydroxy-methylglutaryl-CoA (HMG-CoA) reductase, the enzyme that converts HMG-CoA to mevalonic acid (MVA).	3-hydroxy-3-methylglutaryl-coenzyme A	47-73	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	75-93
31905933-9	2019	Although genes with a role in lipid metabolism, like 3-hydroxy-3-methylglutaryl-coenzym-A--reductase, were overexpressed in tumors of animals with high chemerin-156, total hepatic cholesterol, diacylglycerol and triglyceride levels, and distribution of individual lipid species were normal.	3-hydroxy-3-methylglutaryl-coenzyme A	53-89	retinoic acid receptor responder (tazarotene induced) 2	Mus musculus	152-160
6643457-1	1983	3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) converts HMG-CoA to mevalonate, a key intermediate in the formation of cholesterol and several nonsterol isoprenoid compounds.	3-hydroxy-3-methylglutaryl-coenzyme A	49-56	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Cricetulus griseus	0-47
31817290-2	2019	The mitochondrial HMG-CoA lyase was the first to be described, and catalyzes the cleavage of 3-hydroxy-3-methylglutaryl CoA to acetoacetate and acetyl-CoA, the common final step in ketogenesis and leucine catabolism.	3-hydroxy-3-methylglutaryl-coenzyme A	93-123	3-hydroxy-3-methylglutaryl-CoA lyase	Homo sapiens	18-31
31779269-3	2019	The aims of this study were to verify the mechanisms and therapeutic potential of the ketogenesis rate-limiting enzyme 3-Hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) in HCC.	3-hydroxy-3-methylglutaryl-coenzyme A	119-146	3-hydroxy-3-methylglutaryl-CoA synthase 2	Homo sapiens	159-165
31712757-6	2019	First, HISE1 downregulates the protein levels of the beta-hydroxy beta-methylglutaryl-CoA reductases HMGR1 and HMGR2, which are rate-limiting enzymes in the sterol synthesis pathway, resulting in suppression of sterol overproduction.	3-hydroxy-3-methylglutaryl-coenzyme A	53-89	3-hydroxy-3-methylglutaryl-CoA reductase 2	Arabidopsis thaliana	111-116
30470158-2	2019	HMGR catalyses the reduction of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate at the expense of two NADPH molecules in a two-step reversible reaction.	3-hydroxy-3-methylglutaryl-coenzyme A	32-69	high mobility group AT-hook 1	Homo sapiens	0-4
30470158-2	2019	HMGR catalyses the reduction of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate at the expense of two NADPH molecules in a two-step reversible reaction.	3-hydroxy-3-methylglutaryl-coenzyme A	71-78	high mobility group AT-hook 1	Homo sapiens	0-4
30470158-3	2019	In the present study, we constructed a model of human HMGR (hHMGR) to explore the conformational changes of HMGR in complex with HMG-CoA and NADPH.	3-hydroxy-3-methylglutaryl-coenzyme A	129-136	high mobility group AT-hook 1	Homo sapiens	54-58
30470158-3	2019	In the present study, we constructed a model of human HMGR (hHMGR) to explore the conformational changes of HMGR in complex with HMG-CoA and NADPH.	3-hydroxy-3-methylglutaryl-coenzyme A	129-136	high mobility group AT-hook 1	Homo sapiens	60-65
30470158-3	2019	In the present study, we constructed a model of human HMGR (hHMGR) to explore the conformational changes of HMGR in complex with HMG-CoA and NADPH.	3-hydroxy-3-methylglutaryl-coenzyme A	129-136	high mobility group AT-hook 1	Homo sapiens	61-65
29023415-1	2017	3-Hydroxy-3-methylglutaryl-CoA synthase (HMGS) is one of the rate-limiting enzymes in the mevalonate pathway as it catalyzes the condensation of acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA.	3-hydroxy-3-methylglutaryl-coenzyme A	169-199	hydroxymethylglutaryl-CoA synthase	Saccharomyces cerevisiae S288C	41-45
31469273-1	2019	The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR), in most organisms, catalyzes the four-electron reduction of the thioester (S)-HMG-CoA to the primary alcohol (R)-mevalonate, utilizing NADPH as the hydride donor.	3-hydroxy-3-methylglutaryl-coenzyme A	151-162	high mobility group AT-hook 1	Homo sapiens	70-74
31547031-6	2019	Moreover, AHR significantly decreased hepatic mRNA expression levels of cholesterol synthesis genes, such as 3-hydroxy-3-methylglutaryl CoA reductase, sterol regulatory element-binding transcription factor (SREBP)-2, and low-density lipoprotein receptor, as well as fatty acid synthesis genes, such as SREBP-1c and fatty acid synthase.	3-hydroxy-3-methylglutaryl-coenzyme A	109-139	aryl-hydrocarbon receptor	Mus musculus	10-13
30829216-1	2019	During intrinsic cholesterol formation 3-hydroxy-3-methylgutaryl coenzyme A reductase (HMGCR) converts HMGCoA to mevalonate, in biosynthetic cascade of cholesterol.	3-hydroxy-3-methylglutaryl-coenzyme A	103-109	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	87-92
27585573-2	2016	Feedback inhibition of HMGCoA reductase (HMGCR) catalytic activity in the transformation of HMG-CoA to mevalonate is a significant regulatory step in sterol biosynthetic pathway.	3-hydroxy-3-methylglutaryl-coenzyme A	92-99	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	23-39
29077483-3	2017	Biosynthesis of the plasma cholesterol and other isoprenoids is catalyzed by 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) through the conversion of HMG-CoA to mevalonic acid in mevalonate pathway.	3-hydroxy-3-methylglutaryl-coenzyme A	152-159	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	77-117
29077483-3	2017	Biosynthesis of the plasma cholesterol and other isoprenoids is catalyzed by 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) through the conversion of HMG-CoA to mevalonic acid in mevalonate pathway.	3-hydroxy-3-methylglutaryl-coenzyme A	152-159	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	119-124
26758949-3	2017	The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR) catalyzes the conversion of HMG-CoA to MVA, and is the rate-limiting step in the biosynthesis of cholesterol.	3-hydroxy-3-methylglutaryl-coenzyme A	50-57	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	70-75
28468827-3	2017	Using an RNAi-based screen targeting the majority of the known metabolic proteins, we recently found that oncogenic BRAFV600E up-regulates HMG-CoA lyase (HMGCL), which converts HMG-CoA to acetyl-CoA and a ketone body, acetoacetate, that selectively enhances BRAFV600E-dependent MEK1 activation in human cancer.	3-hydroxy-3-methylglutaryl-coenzyme A	139-146	3-hydroxy-3-methylglutaryl-CoA lyase	Homo sapiens	154-159
28468827-3	2017	Using an RNAi-based screen targeting the majority of the known metabolic proteins, we recently found that oncogenic BRAFV600E up-regulates HMG-CoA lyase (HMGCL), which converts HMG-CoA to acetyl-CoA and a ketone body, acetoacetate, that selectively enhances BRAFV600E-dependent MEK1 activation in human cancer.	3-hydroxy-3-methylglutaryl-coenzyme A	139-146	mitogen-activated protein kinase kinase 1	Homo sapiens	278-282
27585573-2	2016	Feedback inhibition of HMGCoA reductase (HMGCR) catalytic activity in the transformation of HMG-CoA to mevalonate is a significant regulatory step in sterol biosynthetic pathway.	3-hydroxy-3-methylglutaryl-coenzyme A	92-99	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	41-46
22722993-3	2012	The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR, EC 1.1.1.34) catalyzes the conversion of HMG-CoA to mevalonate, which is the first stage in the cytosolic pathway for biosynthesis of isoprenoid in plants.	3-hydroxy-3-methylglutaryl-coenzyme A	93-100	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	4-44
26381177-1	2015	HMG-CoA reductase (HMGCR) catalyzes the conversion of HMG-CoA to mevalonic acid (MVA); this is the rate-limiting enzyme of the mevalonate pathway that synthesizes cholesterol.	3-hydroxy-3-methylglutaryl-coenzyme A	0-7	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	19-24
24270073-1	2014	The enzyme 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR) catalyzes the conversion of HMG-Co-A into mevalonate.	3-hydroxy-3-methylglutaryl-coenzyme A	94-102	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	11-58
22822071-3	2012	Here, we show that several coenzyme A (CoA) derivatives, such as acetyl-CoA, butyryl-CoA, HMG-CoA, and malonyl-CoA, as well as NADPH but not NADP(+), NADH, or NAD(+), act as allosteric activators of recombinant HDAC1 and HDAC2 in vitro following a mixed activation kinetic.	3-hydroxy-3-methylglutaryl-coenzyme A	90-97	2,4-dienoyl-CoA reductase 1	Homo sapiens	127-132
24582968-2	2014	The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR) is the rate-limiting step in cholesterol biosynthesis and catalyzes the conversion of HMG-CoA to MVA.	3-hydroxy-3-methylglutaryl-coenzyme A	50-57	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	70-75
24333427-1	2014	Hydroxymethylglutaryl coenzyme A reductase (HMGCR) catalyzes the rate limiting step in cholesterol biosynthesis converting HMG-CoA into mevalonic acid (MVA), which equilibrates with mevalonic acid lactone (MVL) under neutral pH conditions.	3-hydroxy-3-methylglutaryl-coenzyme A	123-130	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	0-42
24333427-1	2014	Hydroxymethylglutaryl coenzyme A reductase (HMGCR) catalyzes the rate limiting step in cholesterol biosynthesis converting HMG-CoA into mevalonic acid (MVA), which equilibrates with mevalonic acid lactone (MVL) under neutral pH conditions.	3-hydroxy-3-methylglutaryl-coenzyme A	123-130	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	44-49
22722993-3	2012	The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR, EC 1.1.1.34) catalyzes the conversion of HMG-CoA to mevalonate, which is the first stage in the cytosolic pathway for biosynthesis of isoprenoid in plants.	3-hydroxy-3-methylglutaryl-coenzyme A	93-100	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	46-50
22177940-1	2012	The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) catalyzes the conversion of HMG-CoA to mevalonate, a four-electron oxidoreduction that is the rate-limiting step in the synthesis of cholesterol and other isoprenoids.	3-hydroxy-3-methylglutaryl-coenzyme A	95-102	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	11-58
22177940-1	2012	The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) catalyzes the conversion of HMG-CoA to mevalonate, a four-electron oxidoreduction that is the rate-limiting step in the synthesis of cholesterol and other isoprenoids.	3-hydroxy-3-methylglutaryl-coenzyme A	95-102	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	60-65
21118482-1	2010	BACKGROUND: PUFAs are potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme catalyzing the conversion of HMGCoA to mevalonate, the rate limiting step in cholesterol biosynthesis.	3-hydroxy-3-methylglutaryl-coenzyme A	141-147	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	43-100
22645493-2	2012	The aim of the paper was to investigate the effect its dose-dependent drug-drug interaction with simvastatin inhibitor HMGCo-A has on PAI-1 blood level, heart rate and blood pressure.	3-hydroxy-3-methylglutaryl-coenzyme A	119-126	serpin family E member 1	Rattus norvegicus	134-139
20843083-1	2010	Density functional theory was applied to study the binding mode of new flavonoids as possible inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), an enzyme that catalyzes the four-electron reduction of HMGCoA to mevalonate, the committed step in the biosynthesis of sterols.	3-hydroxy-3-methylglutaryl-coenzyme A	217-223	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	112-152
20843083-1	2010	Density functional theory was applied to study the binding mode of new flavonoids as possible inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), an enzyme that catalyzes the four-electron reduction of HMGCoA to mevalonate, the committed step in the biosynthesis of sterols.	3-hydroxy-3-methylglutaryl-coenzyme A	217-223	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	154-158
20418539-3	2010	We propose a rapid and versatile reverse phase-HPLC method for assaying HMGR activity capable of monitoring the levels of both substrates (HMG-CoA and NADPH) and products (CoA, mevalonate, and NADP(+)) in a single 20 min run with no pretreatment required.	3-hydroxy-3-methylglutaryl-coenzyme A	139-146	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	72-76
20019585-2	2010	Statins work by inhibiting HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, thus stopping the conversion of HMG-CoA to mevalonate, which is found in the cholesterol synthesis cascade.	3-hydroxy-3-methylglutaryl-coenzyme A	27-34	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	36-84
20346956-1	2010	3-Hydroxy-3-methylglutaryl coenzyme A (CoA) synthase (HMGCS) catalyzes the condensation of acetyl-CoA and acetoacetyl-CoA into 3-hydroxy-3-methylglutaryl CoA.	3-hydroxy-3-methylglutaryl-coenzyme A	127-157	Coenzyme A synthase	Homo sapiens	27-52
20346956-1	2010	3-Hydroxy-3-methylglutaryl coenzyme A (CoA) synthase (HMGCS) catalyzes the condensation of acetyl-CoA and acetoacetyl-CoA into 3-hydroxy-3-methylglutaryl CoA.	3-hydroxy-3-methylglutaryl-coenzyme A	127-157	3-hydroxy-3-methylglutaryl-CoA synthase 1	Homo sapiens	54-59
18787645-5	2008	Statin, 3-hydroxy-3- methyl-glutaryl (HMG)-CoA reductase inhibitor therapy inhibits conversion of HMG-CoA to mevalonate and lowers plasma CoQ(10) concentrations.	3-hydroxy-3-methylglutaryl-coenzyme A	98-105	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	8-56
17210580-12	2007	Liquid chromatography-tandem mass spectrometry measurements of acetyl-CoA, acetoacetyl-CoA, succinyl-CoA, hydroxymethylglutaryl-CoA, and malonyl-CoA confirmed that they were increased by insulin secretagogues.	3-hydroxy-3-methylglutaryl-coenzyme A	106-131	insulin	Homo sapiens	187-194
12454262-2	2002	HMG-CoA reductase (HMGCR) catalyzes the conversion of HMG-CoA to mevalonate, the rate-limiting step of eukaryotic isoprenoid biosynthesis, and is the main target of cholesterol-lowering drugs.	3-hydroxy-3-methylglutaryl-coenzyme A	0-7	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	19-24
11079678-13	2000	CONCLUSIONS: In humans, SVEC inhibition of HMG-CoA/mevalonate pathway contributes to the enhanced eNOS expression and NO release by cerivastatin, whereas in SMC, inhibition of this pathway only partially explains cerivastatin-induced cell growth arrest.	3-hydroxy-3-methylglutaryl-coenzyme A	43-50	nitric oxide synthase 3	Homo sapiens	98-102
11913531-1	2002	Purpose of the present study was to evaluate the myopathy risk using a urethane infusion method following oral administration of five kinds of commercial HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitors (HCRIs), (pravastatin (PV), simvastatin (SV), cerivastatin (CeV), atorvastatin (AV), and fluvastatin (FV)) alone or with coadministration of bezafibrate (BF).	3-hydroxy-3-methylglutaryl-coenzyme A	154-161	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	163-211
11673457-8	2002	Recombinant PTE-2 showed a broad chain length specificity with acyl-CoAs from short- and medium-, to long-chain acyl-CoAs, and other substrates including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA, and branched chain acyl-CoAs, all of which are present in peroxisomes.	3-hydroxy-3-methylglutaryl-coenzyme A	182-207	acyl-CoA thioesterase 8	Mus musculus	12-17