PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12214853-2	2002	Cryptotanshinone (1) and 15,16-dihydrotanshinone I (3) exhibited potent DGAT inhibitory activities dose-dependently with IC50 values of 10.5 microg/ml and 11.1 microg/ml.	dhts	25-50	diacylglycerol O-acyltransferase 1	Rattus norvegicus	72-76
34538671-0	2022	Dihydrotanshinone I inhibits the growth of hepatoma cells by direct inhibition of Src.	dhts	0-19	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	82-85
10575380-3	1999	Among them, 15,16-dihydrotanshinone-I and cryptotanshinone demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells in a dose-dependent manner; the IC50 values were calculated as 16 and 36 microM, respectively.	dhts	12-37	O-GlcNAcase	Rattus norvegicus	113-132
10575380-3	1999	Among them, 15,16-dihydrotanshinone-I and cryptotanshinone demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells in a dose-dependent manner; the IC50 values were calculated as 16 and 36 microM, respectively.	dhts	12-37	RB transcriptional corepressor like 2	Rattus norvegicus	147-152
34318905-6	2021	In addition, DHT significantly reduced MAD2 expression, a target of HuR with a relevant role in ATC.	dhts	13-16	mitotic arrest deficient 2 like 1	Homo sapiens	39-43
34721038-0	2021	Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo.	dhts	0-19	NLR family, pyrin domain containing 3	Mus musculus	42-47
34721038-3	2021	We found that dihydrotanshinone I (DHT) specifically blocked the canonical and non-canonical activation of the NLRP3 inflammasome.	dhts	14-33	NLR family, pyrin domain containing 3	Mus musculus	111-116
34581263-4	2021	The databases MEDLINE, PsycINFO, EMBASE, Web of Science, CNKI, WANFANG, and VIP were systemically searched for English and Chinese language articles evaluating DHTs for people with mental health problems in mainland China.	dhts	160-164	vasoactive intestinal peptide	Homo sapiens	76-79
34318905-6	2021	In addition, DHT significantly reduced MAD2 expression, a target of HuR with a relevant role in ATC.	dhts	13-16	ELAV like RNA binding protein 1	Homo sapiens	68-71
34318905-8	2021	In conclusion, to the best of our knowledge, the present study is the first to demonstrate that DHT exerts antitumor effects on ATC cells by reducing MAD2 expression levels.	dhts	96-99	mitotic arrest deficient 2 like 1	Homo sapiens	150-154
34531747-0	2021	Enhanced Bioavailability of Dihydrotanshinone I-Bovine Serum Albumin Nanoparticles for Stroke Therapy.	dhts	28-47	albumin	Rattus norvegicus	55-68
34062127-0	2021	Identification of dihydrotanshinone I as an ERp57 inhibitor with anti-breast cancer properties via the UPR pathway.	dhts	18-37	protein disulfide isomerase family A member 3	Homo sapiens	44-49
34062127-3	2021	Herein, the active ingredient dihydrotanshinone I (DHT) in Salvia miltiorrhiza extract (SME), which binds ERp57 was identified and verified by an enzymatic solid-phase method combined with LC-MS/MS.	dhts	30-49	protein disulfide isomerase family A member 3	Homo sapiens	106-111
34198325-7	2021	We developed a protease assay that was used to screen a custom compound library from which we identified dihydrotanshinone I and Ro 08-2750 as compounds that inhibit PLpro in protease and isopeptidase assays and also inhibit viral replication in cell culture-based assays.	dhts	105-124	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	166-171
34457194-0	2021	STAT3-mediated activation of mitochondrial pathway contributes to antitumor effect of dihydrotanshinone I in esophageal squamous cell carcinoma cells.	dhts	86-105	signal transducer and activator of transcription 3	Homo sapiens	0-5
34457194-8	2021	Immunofluorescence was used to detect the expression of phosphorylated STAT3 (pSTAT3) in DHTS-treated ESCC cells.	dhts	89-93	signal transducer and activator of transcription 3	Homo sapiens	71-76
34457194-13	2021	Annexin V-PE/7-AAD double staining assay and Hoechst 33258 staining revealed that DHTS induced obvious apoptosis in KYSE30 and Eca109 cells.	dhts	82-86	annexin A5	Homo sapiens	0-9
34457194-17	2021	CONCLUSION: DHTS exerts antitumor effect in ESCC via STAT3-mediated activation of the mitochondrial pathway.	dhts	12-16	signal transducer and activator of transcription 3	Homo sapiens	53-58
34400891-6	2021	Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed downregulated activity of the hypoxia-inducible factor 1 alpha (HIF-1alpha) signaling pathway in EOMA cells following treatment with DHTS.	dhts	199-203	hypoxia inducible factor 1, alpha subunit	Mus musculus	96-128
34400891-6	2021	Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed downregulated activity of the hypoxia-inducible factor 1 alpha (HIF-1alpha) signaling pathway in EOMA cells following treatment with DHTS.	dhts	199-203	hypoxia inducible factor 1, alpha subunit	Mus musculus	130-140
34400891-8	2021	Our results revealed that DHTS downregulated HIF-1alpha expression by interfering in its posttranscriptional processing, and the RNA-binding protein HuR participated in this mechanism.	dhts	26-30	hypoxia inducible factor 1, alpha subunit	Mus musculus	45-55
34400891-8	2021	Our results revealed that DHTS downregulated HIF-1alpha expression by interfering in its posttranscriptional processing, and the RNA-binding protein HuR participated in this mechanism.	dhts	26-30	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)	Mus musculus	149-152
34319041-9	2021	RESULTS: MTT assay revealed IC50 of MDA-MB-468 cells at 2 microM for 24 h. Subsequently, DHTS treatment in TNBC cell lines (MDA-MB-468 and MDA-MB-231) led to decrease in mesenchymal markers i.e. vimentin, N-cadherin and, active beta-catenin.	dhts	89-93	vimentin	Homo sapiens	195-203
34319041-9	2021	RESULTS: MTT assay revealed IC50 of MDA-MB-468 cells at 2 microM for 24 h. Subsequently, DHTS treatment in TNBC cell lines (MDA-MB-468 and MDA-MB-231) led to decrease in mesenchymal markers i.e. vimentin, N-cadherin and, active beta-catenin.	dhts	89-93	cadherin 2	Homo sapiens	205-215
34319041-9	2021	RESULTS: MTT assay revealed IC50 of MDA-MB-468 cells at 2 microM for 24 h. Subsequently, DHTS treatment in TNBC cell lines (MDA-MB-468 and MDA-MB-231) led to decrease in mesenchymal markers i.e. vimentin, N-cadherin and, active beta-catenin.	dhts	89-93	catenin beta 1	Homo sapiens	228-240
34319041-10	2021	DHTS treated MDA-MB-468 cells showed a decrease in adhesion protein CD44 and an increase in epithelial protein E-cadherin.	dhts	0-4	CD44 molecule (Indian blood group)	Homo sapiens	68-72
34319041-10	2021	DHTS treated MDA-MB-468 cells showed a decrease in adhesion protein CD44 and an increase in epithelial protein E-cadherin.	dhts	0-4	cadherin 1	Homo sapiens	111-121
34243610-0	2021	Dihydrotanshinone I inhibits aortic valve interstitial cell calcification via the SMAD1/5/8/NF-kappaB/ERK pathway.	dhts	0-19	SMAD family member 1	Homo sapiens	82-91
34243610-0	2021	Dihydrotanshinone I inhibits aortic valve interstitial cell calcification via the SMAD1/5/8/NF-kappaB/ERK pathway.	dhts	0-19	nuclear factor kappa B subunit 1	Homo sapiens	92-101
34243610-0	2021	Dihydrotanshinone I inhibits aortic valve interstitial cell calcification via the SMAD1/5/8/NF-kappaB/ERK pathway.	dhts	0-19	mitogen-activated protein kinase 1	Homo sapiens	102-105
35074488-0	2022	Dihydrotanshinone I inhibits ovarian tumor growth by activating oxidative stress through Keap1-mediated Nrf2 ubiquitination degradation.	dhts	0-19	kelch like ECH associated protein 1	Homo sapiens	89-94
35074488-0	2022	Dihydrotanshinone I inhibits ovarian tumor growth by activating oxidative stress through Keap1-mediated Nrf2 ubiquitination degradation.	dhts	0-19	NFE2 like bZIP transcription factor 2	Homo sapiens	104-108
33995073-9	2021	Immunofluorescence results have showed that DHTS decreased STAT3 nuclear translocation.	dhts	44-48	signal transducer and activator of transcription 3	Homo sapiens	59-64
34034851-10	2021	The development of DHT-specific content for HTA frameworks is hampered by DHTs having varied benefit and risk profiles.	dhts	74-78	hepatocellular carcinoma associated transcript 5	Homo sapiens	44-47
34034851-11	2021	By focusing on DHTs that actively monitor/treat chronic noncommunicable diseases at home, we have extended DHT-specific content to all nine HTA Core Model domains.	dhts	15-19	hepatocellular carcinoma associated transcript 5	Homo sapiens	140-143
33995073-10	2021	Moreover, Western blot results have demonstrated that DHTS suppressed the activation of JAK2/STAT3 signaling pathway.	dhts	54-58	Janus kinase 2	Homo sapiens	88-92
33995073-10	2021	Moreover, Western blot results have demonstrated that DHTS suppressed the activation of JAK2/STAT3 signaling pathway.	dhts	54-58	signal transducer and activator of transcription 3	Homo sapiens	93-98
33995073-11	2021	In addition, xenograft results have showed that DHTS suppressed tumor growth of SMMC7721 cells in vivo by inhibiting the p-STAT3.	dhts	48-52	signal transducer and activator of transcription 3	Homo sapiens	123-128
33995073-12	2021	Thus, we demonstrated that DHTS could inhibit HCC by suppressing the JAK2/STAT3 pathway.	dhts	27-31	Janus kinase 2	Homo sapiens	69-73
33995073-12	2021	Thus, we demonstrated that DHTS could inhibit HCC by suppressing the JAK2/STAT3 pathway.	dhts	27-31	signal transducer and activator of transcription 3	Homo sapiens	74-79
32169842-6	2020	Accordingly, targeting HuR by its inhibitor DHTS inhibited splenic Th17 cell differentiation and reduced experimental autoimmune encephalomyelitis severity.	dhts	44-48	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)	Mus musculus	23-26
33291318-4	2020	Molecular Mechanics/Generalized Born Surface Area (MM/GBSA) rescoring and structural fingerprint clustering of docking poses from virtual screening highlighted that the diterpenoid dihydrotanshinone (DHTS) clustered with the well-known P2X7R antagonist JNJ47965567.	dhts	200-204	purinergic receptor P2X 7	Homo sapiens	236-241
33291318-10	2020	In conclusion, we provided new findings pointing out the therapeutic potential of DHTS, which is an inhibitor of P2X7R, in terms of preventing and/or counteracting the BRB dysfunctions elicited by HG conditions.	dhts	82-86	purinergic receptor P2X 7	Homo sapiens	113-118
32323566-0	2021	Dihydrotanshinone I attenuates plaque vulnerability in ApoE-/- mice: role of RIP3.	dhts	0-19	apolipoprotein E	Mus musculus	55-59
32323566-0	2021	Dihydrotanshinone I attenuates plaque vulnerability in ApoE-/- mice: role of RIP3.	dhts	0-19	myosin phosphatase Rho interacting protein	Mus musculus	77-81
33532181-3	2021	Dihydrotanshinone-I (DT) is an active component in Salvia miltiorrhiza with NRF2 induction potency.	dhts	0-19	nuclear factor, erythroid derived 2, like 2	Mus musculus	76-80
32447214-12	2020	Results showed DHTS significantly reduced DAI, intestinal mucosal damage and inflammatory response in CIM mice by decreasing serum IL-6 and TNFalpha.	dhts	15-19	interleukin 6	Mus musculus	131-135
32447214-12	2020	Results showed DHTS significantly reduced DAI, intestinal mucosal damage and inflammatory response in CIM mice by decreasing serum IL-6 and TNFalpha.	dhts	15-19	tumor necrosis factor	Mus musculus	140-148
32678213-8	2020	We found that dihydrotanshinone-I (DHTS-I), a plant-derived product which prevents HuR binding to specific RNAs, prevented HuR-mediated upregulation of TRIM21, while increasing the HuR-mediated upregulation of p53.	dhts	14-33	ELAV like RNA binding protein 1	Homo sapiens	83-86
32678213-8	2020	We found that dihydrotanshinone-I (DHTS-I), a plant-derived product which prevents HuR binding to specific RNAs, prevented HuR-mediated upregulation of TRIM21, while increasing the HuR-mediated upregulation of p53.	dhts	14-33	ELAV like RNA binding protein 1	Homo sapiens	123-126
32678213-8	2020	We found that dihydrotanshinone-I (DHTS-I), a plant-derived product which prevents HuR binding to specific RNAs, prevented HuR-mediated upregulation of TRIM21, while increasing the HuR-mediated upregulation of p53.	dhts	14-33	tripartite motif containing 21	Homo sapiens	152-158
32678213-8	2020	We found that dihydrotanshinone-I (DHTS-I), a plant-derived product which prevents HuR binding to specific RNAs, prevented HuR-mediated upregulation of TRIM21, while increasing the HuR-mediated upregulation of p53.	dhts	14-33	ELAV like RNA binding protein 1	Homo sapiens	123-126
32678213-8	2020	We found that dihydrotanshinone-I (DHTS-I), a plant-derived product which prevents HuR binding to specific RNAs, prevented HuR-mediated upregulation of TRIM21, while increasing the HuR-mediated upregulation of p53.	dhts	14-33	tumor protein p53	Homo sapiens	210-213
30799630-0	2019	HIF-1alpha Preconditioning Potentiates Antioxidant Activity in Ischemic Injury: The Role of Sequential Administration of Dihydrotanshinone I and Protocatechuic Aldehyde in Cardioprotection.	dhts	121-140	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10
32200384-5	2020	RESULTS: In the current study, we discover that dihydrotanshinone I (DTS I), extracted from Radix Salviae, can obviously inhibit mTOR phosphorylation and increase autophagy via increasing AMPK phosphorylation.	dhts	48-67	mechanistic target of rapamycin kinase	Homo sapiens	129-133
32200384-5	2020	RESULTS: In the current study, we discover that dihydrotanshinone I (DTS I), extracted from Radix Salviae, can obviously inhibit mTOR phosphorylation and increase autophagy via increasing AMPK phosphorylation.	dhts	48-67	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	188-192
29689254-10	2018	Dihydrotanshinone I had moderate noncompetitive inhibition on CYP2J2 (Ki = 6.59 muM), but mechanism-based inhibition on CYP2C8 (KI = 0.43 muM, kinact = 0.097 min-1).	dhts	0-19	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	62-68
31379467-0	2019	Dihydrotanshinone I Alleviates Crystalline Silica-Induced Pulmonary Inflammation by Regulation of the Th Immune Response and Inhibition of STAT1/STAT3.	dhts	0-19	signal transducer and activator of transcription 1	Mus musculus	139-144
31379467-0	2019	Dihydrotanshinone I Alleviates Crystalline Silica-Induced Pulmonary Inflammation by Regulation of the Th Immune Response and Inhibition of STAT1/STAT3.	dhts	0-19	signal transducer and activator of transcription 3	Mus musculus	145-150
31308689-0	2019	Dihydrotanshinone I inhibits the growth of osteosarcoma through the Wnt/beta-catenin signaling pathway.	dhts	0-19	catenin (cadherin associated protein), beta 1	Mus musculus	72-84
31019654-5	2019	DHTS induced NOX5 activation by increasing calcium, and NOX5 activation induced reactive oxygen species (ROS) production.	dhts	0-4	NADPH oxidase 5	Homo sapiens	13-17
31019654-7	2019	DHTS deregulated the dynamic equilibrium from non-stem cancer cells to CSCs by dephosphorylating Stat3 and decreasing IL-6 secretion and inhibiting CSC formation.	dhts	0-4	signal transducer and activator of transcription 3	Homo sapiens	97-102
31019654-7	2019	DHTS deregulated the dynamic equilibrium from non-stem cancer cells to CSCs by dephosphorylating Stat3 and decreasing IL-6 secretion and inhibiting CSC formation.	dhts	0-4	interleukin 6	Homo sapiens	118-122
31019654-8	2019	These novel findings showed that DHTS-induced ROS deregulated the Stat3/IL-6 pathway and induced CSC death.	dhts	33-37	signal transducer and activator of transcription 3	Homo sapiens	66-71
31019654-8	2019	These novel findings showed that DHTS-induced ROS deregulated the Stat3/IL-6 pathway and induced CSC death.	dhts	33-37	interleukin 6	Homo sapiens	72-76
31019654-9	2019	NOX5 activation by DHTS inhibits CSC formation through ROS/Stat3/IL-6 signaling, and DHTS may be a promising potential therapeutic agent against breast CSCs.	dhts	19-23	NADPH oxidase 5	Homo sapiens	0-4
31019654-9	2019	NOX5 activation by DHTS inhibits CSC formation through ROS/Stat3/IL-6 signaling, and DHTS may be a promising potential therapeutic agent against breast CSCs.	dhts	19-23	signal transducer and activator of transcription 3	Homo sapiens	59-64
31019654-9	2019	NOX5 activation by DHTS inhibits CSC formation through ROS/Stat3/IL-6 signaling, and DHTS may be a promising potential therapeutic agent against breast CSCs.	dhts	19-23	interleukin 6	Homo sapiens	65-69
29689254-10	2018	Dihydrotanshinone I had moderate noncompetitive inhibition on CYP2J2 (Ki = 6.59 muM), but mechanism-based inhibition on CYP2C8 (KI = 0.43 muM, kinact = 0.097 min-1).	dhts	0-19	latexin	Homo sapiens	80-83
29689254-10	2018	Dihydrotanshinone I had moderate noncompetitive inhibition on CYP2J2 (Ki = 6.59 muM), but mechanism-based inhibition on CYP2C8 (KI = 0.43 muM, kinact = 0.097 min-1).	dhts	0-19	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	120-126
29689254-10	2018	Dihydrotanshinone I had moderate noncompetitive inhibition on CYP2J2 (Ki = 6.59 muM), but mechanism-based inhibition on CYP2C8 (KI = 0.43 muM, kinact = 0.097 min-1).	dhts	0-19	latexin	Homo sapiens	138-141
30003065-4	2018	Therefore, the present study investigated the anti-cancer effect of DHTS in terms of cell cycle regulation and the regulation of the AMP-activated protein kinase (AMPK)/Akt/mTOR signaling pathway in SK-HEP-1 human hepatocellular carcinoma cells.	dhts	68-72	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	133-161
30003065-4	2018	Therefore, the present study investigated the anti-cancer effect of DHTS in terms of cell cycle regulation and the regulation of the AMP-activated protein kinase (AMPK)/Akt/mTOR signaling pathway in SK-HEP-1 human hepatocellular carcinoma cells.	dhts	68-72	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	163-167
30003065-4	2018	Therefore, the present study investigated the anti-cancer effect of DHTS in terms of cell cycle regulation and the regulation of the AMP-activated protein kinase (AMPK)/Akt/mTOR signaling pathway in SK-HEP-1 human hepatocellular carcinoma cells.	dhts	68-72	AKT serine/threonine kinase 1	Homo sapiens	169-172
30003065-4	2018	Therefore, the present study investigated the anti-cancer effect of DHTS in terms of cell cycle regulation and the regulation of the AMP-activated protein kinase (AMPK)/Akt/mTOR signaling pathway in SK-HEP-1 human hepatocellular carcinoma cells.	dhts	68-72	mechanistic target of rapamycin kinase	Homo sapiens	173-177
30003065-5	2018	Methods: The anti-proliferative effects of DHTS were evaluated by the sulforhodamine B assay in SK-HEP-1 cells.	dhts	43-47	DNL-type zinc finger	Homo sapiens	99-104
30003065-8	2018	Results: DHTS showed a significant anti-proliferative activity against SK-HEP-1 cells.	dhts	9-13	DNL-type zinc finger	Homo sapiens	74-79
30003065-9	2018	DHTS induced cell cycle arrest in the G0/G1 phase, which was mediated by downregulation of cyclin D1, cyclin A, cyclin E, CDK4, CDK2, c-Myc and p-Rb expression and with increased expression of the CDK inhibitor p21.	dhts	0-4	cyclin D1	Homo sapiens	91-100
30003065-9	2018	DHTS induced cell cycle arrest in the G0/G1 phase, which was mediated by downregulation of cyclin D1, cyclin A, cyclin E, CDK4, CDK2, c-Myc and p-Rb expression and with increased expression of the CDK inhibitor p21.	dhts	0-4	cyclin A2	Homo sapiens	102-110
30003065-9	2018	DHTS induced cell cycle arrest in the G0/G1 phase, which was mediated by downregulation of cyclin D1, cyclin A, cyclin E, CDK4, CDK2, c-Myc and p-Rb expression and with increased expression of the CDK inhibitor p21.	dhts	0-4	cyclin dependent kinase 4	Homo sapiens	122-126
30003065-9	2018	DHTS induced cell cycle arrest in the G0/G1 phase, which was mediated by downregulation of cyclin D1, cyclin A, cyclin E, CDK4, CDK2, c-Myc and p-Rb expression and with increased expression of the CDK inhibitor p21.	dhts	0-4	cyclin dependent kinase 2	Homo sapiens	128-132
30003065-9	2018	DHTS induced cell cycle arrest in the G0/G1 phase, which was mediated by downregulation of cyclin D1, cyclin A, cyclin E, CDK4, CDK2, c-Myc and p-Rb expression and with increased expression of the CDK inhibitor p21.	dhts	0-4	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	134-139
30003065-9	2018	DHTS induced cell cycle arrest in the G0/G1 phase, which was mediated by downregulation of cyclin D1, cyclin A, cyclin E, CDK4, CDK2, c-Myc and p-Rb expression and with increased expression of the CDK inhibitor p21.	dhts	0-4	RB transcriptional corepressor 1	Homo sapiens	144-148
30003065-9	2018	DHTS induced cell cycle arrest in the G0/G1 phase, which was mediated by downregulation of cyclin D1, cyclin A, cyclin E, CDK4, CDK2, c-Myc and p-Rb expression and with increased expression of the CDK inhibitor p21.	dhts	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	211-214
30003065-10	2018	DHTS also activated the AMPK signaling.	dhts	0-4	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	24-28
30003065-11	2018	In addition, DHTS downregulated the Akt/mTOR and MAPK signaling pathways.	dhts	13-17	AKT serine/threonine kinase 1	Homo sapiens	36-39
30003065-11	2018	In addition, DHTS downregulated the Akt/mTOR and MAPK signaling pathways.	dhts	13-17	mechanistic target of rapamycin kinase	Homo sapiens	40-44
30003065-12	2018	Conclusions: Our results suggest that the anti-proliferative activity of DHTS might be associated with the induction of G0/G1 phase cell cycle arrest and regulation of AMPK/Akt/mTOR and MAPK signaling pathways in SK-HEP-1 cells.	dhts	73-77	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	168-172
30003065-12	2018	Conclusions: Our results suggest that the anti-proliferative activity of DHTS might be associated with the induction of G0/G1 phase cell cycle arrest and regulation of AMPK/Akt/mTOR and MAPK signaling pathways in SK-HEP-1 cells.	dhts	73-77	AKT serine/threonine kinase 1	Homo sapiens	173-176
30003065-12	2018	Conclusions: Our results suggest that the anti-proliferative activity of DHTS might be associated with the induction of G0/G1 phase cell cycle arrest and regulation of AMPK/Akt/mTOR and MAPK signaling pathways in SK-HEP-1 cells.	dhts	73-77	mechanistic target of rapamycin kinase	Homo sapiens	177-181
30003065-12	2018	Conclusions: Our results suggest that the anti-proliferative activity of DHTS might be associated with the induction of G0/G1 phase cell cycle arrest and regulation of AMPK/Akt/mTOR and MAPK signaling pathways in SK-HEP-1 cells.	dhts	73-77	DNL-type zinc finger	Homo sapiens	216-221
29313684-2	2018	We previously found that dihydrotanshinone-I (DHTS, 1) prevents the association of HuR with its RNA substrate, thus imparing its function.	dhts	25-44	ELAV like RNA binding protein 1	Homo sapiens	83-86
29313684-2	2018	We previously found that dihydrotanshinone-I (DHTS, 1) prevents the association of HuR with its RNA substrate, thus imparing its function.	dhts	46-50	ELAV like RNA binding protein 1	Homo sapiens	83-86
26553968-0	2015	Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function.	dhts	0-19	ELAV like RNA binding protein 1	Homo sapiens	64-67
29259227-4	2017	We found that 15,16-dihydrotanshinone I (DHTS), as a C1-Ten protein tyrosine phosphatase inhibitor, increased IRS-1 stability, improved glucose tolerance and reduced muscle atrophy.	dhts	14-39	tensin 2	Homo sapiens	53-59
29259227-4	2017	We found that 15,16-dihydrotanshinone I (DHTS), as a C1-Ten protein tyrosine phosphatase inhibitor, increased IRS-1 stability, improved glucose tolerance and reduced muscle atrophy.	dhts	14-39	insulin receptor substrate 1	Homo sapiens	110-115
29259227-4	2017	We found that 15,16-dihydrotanshinone I (DHTS), as a C1-Ten protein tyrosine phosphatase inhibitor, increased IRS-1 stability, improved glucose tolerance and reduced muscle atrophy.	dhts	41-45	tensin 2	Homo sapiens	53-59
29259227-4	2017	We found that 15,16-dihydrotanshinone I (DHTS), as a C1-Ten protein tyrosine phosphatase inhibitor, increased IRS-1 stability, improved glucose tolerance and reduced muscle atrophy.	dhts	41-45	insulin receptor substrate 1	Homo sapiens	110-115
29259227-5	2017	Identification of DHTS as a C1-Ten inhibitor revealed a new function of C1-Ten in AMPK inhibition, possibly through regulation of IRS-1.	dhts	18-22	tensin 2	Homo sapiens	28-34
29259227-5	2017	Identification of DHTS as a C1-Ten inhibitor revealed a new function of C1-Ten in AMPK inhibition, possibly through regulation of IRS-1.	dhts	18-22	tensin 2	Homo sapiens	72-78
29259227-5	2017	Identification of DHTS as a C1-Ten inhibitor revealed a new function of C1-Ten in AMPK inhibition, possibly through regulation of IRS-1.	dhts	18-22	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	82-86
29259227-5	2017	Identification of DHTS as a C1-Ten inhibitor revealed a new function of C1-Ten in AMPK inhibition, possibly through regulation of IRS-1.	dhts	18-22	insulin receptor substrate 1	Homo sapiens	130-135
29259227-6	2017	These findings suggest that C1-Ten inhibition by DHTS could provide a novel therapeutic strategy for insulin resistance-associated metabolic syndrome through dual targeting of IRS-1 and AMPK.	dhts	49-53	tensin 2	Homo sapiens	28-34
29259227-6	2017	These findings suggest that C1-Ten inhibition by DHTS could provide a novel therapeutic strategy for insulin resistance-associated metabolic syndrome through dual targeting of IRS-1 and AMPK.	dhts	49-53	insulin	Homo sapiens	101-108
29259227-6	2017	These findings suggest that C1-Ten inhibition by DHTS could provide a novel therapeutic strategy for insulin resistance-associated metabolic syndrome through dual targeting of IRS-1 and AMPK.	dhts	49-53	insulin receptor substrate 1	Homo sapiens	176-181
29259227-6	2017	These findings suggest that C1-Ten inhibition by DHTS could provide a novel therapeutic strategy for insulin resistance-associated metabolic syndrome through dual targeting of IRS-1 and AMPK.	dhts	49-53	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	186-190
28257144-0	2017	The anti-hepatic fibrosis effects of dihydrotanshinone I are mediated by disrupting the yes-associated protein and transcriptional enhancer factor D2 complex and stimulating autophagy.	dhts	37-56	Yes1 associated transcriptional regulator	Rattus norvegicus	88-110
26547530-12	2015	The apoptosis induced by DHTS was suppressed by knockdown of apoptosis inducing factor (AIF), inhibition of caspase-3/9 but was increased after knockdown of caspase-2.	dhts	25-29	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	61-86
26547530-12	2015	The apoptosis induced by DHTS was suppressed by knockdown of apoptosis inducing factor (AIF), inhibition of caspase-3/9 but was increased after knockdown of caspase-2.	dhts	25-29	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	88-91
26547530-12	2015	The apoptosis induced by DHTS was suppressed by knockdown of apoptosis inducing factor (AIF), inhibition of caspase-3/9 but was increased after knockdown of caspase-2.	dhts	25-29	caspase 3	Mus musculus	108-119
26547530-12	2015	The apoptosis induced by DHTS was suppressed by knockdown of apoptosis inducing factor (AIF), inhibition of caspase-3/9 but was increased after knockdown of caspase-2.	dhts	25-29	caspase 2	Mus musculus	157-166
26547530-13	2015	Meantime, knockdown of caspase-2, pretreatment with Z-VAD-fmk or NAC (N-Acety-L-Cysteine) efficiently inhibited the autophagy induced by DHTS.	dhts	137-141	caspase 2	Mus musculus	23-32
29441017-14	2018	DHTS increased the expression of several apoptosis-related proteins, including caspase9, caspase3, PARP, AIF, BAX, cytochrome c, caspase8 and FADD and significantly inhibited angiogenesis, as indicated by reduced tube formation and diminished expression of vascular endothelial cell growth factor receptor 2 and matrix metalloproteinase 9.	dhts	0-4	caspase 9	Mus musculus	79-87
29441017-14	2018	DHTS increased the expression of several apoptosis-related proteins, including caspase9, caspase3, PARP, AIF, BAX, cytochrome c, caspase8 and FADD and significantly inhibited angiogenesis, as indicated by reduced tube formation and diminished expression of vascular endothelial cell growth factor receptor 2 and matrix metalloproteinase 9.	dhts	0-4	caspase 3	Mus musculus	89-97
29441017-14	2018	DHTS increased the expression of several apoptosis-related proteins, including caspase9, caspase3, PARP, AIF, BAX, cytochrome c, caspase8 and FADD and significantly inhibited angiogenesis, as indicated by reduced tube formation and diminished expression of vascular endothelial cell growth factor receptor 2 and matrix metalloproteinase 9.	dhts	0-4	poly (ADP-ribose) polymerase family, member 1	Mus musculus	99-103
29441017-14	2018	DHTS increased the expression of several apoptosis-related proteins, including caspase9, caspase3, PARP, AIF, BAX, cytochrome c, caspase8 and FADD and significantly inhibited angiogenesis, as indicated by reduced tube formation and diminished expression of vascular endothelial cell growth factor receptor 2 and matrix metalloproteinase 9.	dhts	0-4	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	105-108
29441017-14	2018	DHTS increased the expression of several apoptosis-related proteins, including caspase9, caspase3, PARP, AIF, BAX, cytochrome c, caspase8 and FADD and significantly inhibited angiogenesis, as indicated by reduced tube formation and diminished expression of vascular endothelial cell growth factor receptor 2 and matrix metalloproteinase 9.	dhts	0-4	BCL2-associated X protein	Mus musculus	110-113
29441017-14	2018	DHTS increased the expression of several apoptosis-related proteins, including caspase9, caspase3, PARP, AIF, BAX, cytochrome c, caspase8 and FADD and significantly inhibited angiogenesis, as indicated by reduced tube formation and diminished expression of vascular endothelial cell growth factor receptor 2 and matrix metalloproteinase 9.	dhts	0-4	caspase 8	Mus musculus	129-137
29441017-14	2018	DHTS increased the expression of several apoptosis-related proteins, including caspase9, caspase3, PARP, AIF, BAX, cytochrome c, caspase8 and FADD and significantly inhibited angiogenesis, as indicated by reduced tube formation and diminished expression of vascular endothelial cell growth factor receptor 2 and matrix metalloproteinase 9.	dhts	0-4	Fas (TNFRSF6)-associated via death domain	Mus musculus	142-146
29441017-14	2018	DHTS increased the expression of several apoptosis-related proteins, including caspase9, caspase3, PARP, AIF, BAX, cytochrome c, caspase8 and FADD and significantly inhibited angiogenesis, as indicated by reduced tube formation and diminished expression of vascular endothelial cell growth factor receptor 2 and matrix metalloproteinase 9.	dhts	0-4	matrix metallopeptidase 9	Mus musculus	266-338
28934484-0	2017	Regulation of HuR structure and function by dihydrotanshinone-I.	dhts	44-63	ELAV like RNA binding protein 1	Homo sapiens	14-17
28934484-2	2017	The natural product dihydrotanshinone-I (DHTS) prevents the association of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to RNA.	dhts	20-39	ELAV like RNA binding protein 1	Homo sapiens	75-78
28934484-2	2017	The natural product dihydrotanshinone-I (DHTS) prevents the association of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to RNA.	dhts	20-39	ELAV like RNA binding protein 1	Homo sapiens	161-164
28934484-2	2017	The natural product dihydrotanshinone-I (DHTS) prevents the association of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to RNA.	dhts	41-45	ELAV like RNA binding protein 1	Homo sapiens	75-78
28934484-2	2017	The natural product dihydrotanshinone-I (DHTS) prevents the association of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to RNA.	dhts	41-45	ELAV like RNA binding protein 1	Homo sapiens	161-164
28934484-3	2017	Here, we report the structural determinants of the interaction between DHTS and HuR and the impact of DHTS on HuR binding to target mRNAs transcriptome-wide.	dhts	71-75	ELAV like RNA binding protein 1	Homo sapiens	80-83
28934484-3	2017	Here, we report the structural determinants of the interaction between DHTS and HuR and the impact of DHTS on HuR binding to target mRNAs transcriptome-wide.	dhts	102-106	ELAV like RNA binding protein 1	Homo sapiens	110-113
28934484-4	2017	NMR titration and Molecular Dynamics simulation identified the residues within RRM1 and RRM2 responsible for the interaction between DHTS and HuR.	dhts	133-137	ribonucleotide reductase catalytic subunit M1	Homo sapiens	79-83
28934484-4	2017	NMR titration and Molecular Dynamics simulation identified the residues within RRM1 and RRM2 responsible for the interaction between DHTS and HuR.	dhts	133-137	ribonucleotide reductase regulatory subunit M2	Homo sapiens	88-92
28934484-4	2017	NMR titration and Molecular Dynamics simulation identified the residues within RRM1 and RRM2 responsible for the interaction between DHTS and HuR.	dhts	133-137	ELAV like RNA binding protein 1	Homo sapiens	142-145
28934484-5	2017	RNA Electromobility Shifts and Alpha Screen Assays showed that DHTS interacts with HuR through the same binding regions as target RNAs, stabilizing HuR in a locked conformation that hampers RNA binding competitively.	dhts	63-67	ELAV like RNA binding protein 1	Homo sapiens	83-86
28934484-5	2017	RNA Electromobility Shifts and Alpha Screen Assays showed that DHTS interacts with HuR through the same binding regions as target RNAs, stabilizing HuR in a locked conformation that hampers RNA binding competitively.	dhts	63-67	ELAV like RNA binding protein 1	Homo sapiens	148-151
28934484-7	2017	In vivo, DHTS potently inhibited xenograft tumor growth in a HuR-dependent model without systemic toxicity.	dhts	9-13	ELAV like RNA binding protein 1	Homo sapiens	61-64
26478521-7	2017	RESULTS: DHTI treatment inhibited the proliferation of 143B cells in a dose- and time-dependent manner through arresting cells in G1 phase by reducing the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6, p-Rb, E2F1, SKP2 and increasing the expression of P53, P21cip1, P27kip1.	dhts	9-13	cyclin D1	Homo sapiens	169-178
26478521-7	2017	RESULTS: DHTI treatment inhibited the proliferation of 143B cells in a dose- and time-dependent manner through arresting cells in G1 phase by reducing the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6, p-Rb, E2F1, SKP2 and increasing the expression of P53, P21cip1, P27kip1.	dhts	9-13	cyclin E1	Homo sapiens	180-189
26478521-7	2017	RESULTS: DHTI treatment inhibited the proliferation of 143B cells in a dose- and time-dependent manner through arresting cells in G1 phase by reducing the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6, p-Rb, E2F1, SKP2 and increasing the expression of P53, P21cip1, P27kip1.	dhts	9-13	cyclin dependent kinase 2	Homo sapiens	191-195
26478521-7	2017	RESULTS: DHTI treatment inhibited the proliferation of 143B cells in a dose- and time-dependent manner through arresting cells in G1 phase by reducing the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6, p-Rb, E2F1, SKP2 and increasing the expression of P53, P21cip1, P27kip1.	dhts	9-13	cyclin dependent kinase 4	Homo sapiens	197-201
26478521-7	2017	RESULTS: DHTI treatment inhibited the proliferation of 143B cells in a dose- and time-dependent manner through arresting cells in G1 phase by reducing the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6, p-Rb, E2F1, SKP2 and increasing the expression of P53, P21cip1, P27kip1.	dhts	9-13	cyclin dependent kinase 6	Homo sapiens	203-207
26478521-7	2017	RESULTS: DHTI treatment inhibited the proliferation of 143B cells in a dose- and time-dependent manner through arresting cells in G1 phase by reducing the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6, p-Rb, E2F1, SKP2 and increasing the expression of P53, P21cip1, P27kip1.	dhts	9-13	RB transcriptional corepressor 1	Homo sapiens	209-213
26478521-7	2017	RESULTS: DHTI treatment inhibited the proliferation of 143B cells in a dose- and time-dependent manner through arresting cells in G1 phase by reducing the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6, p-Rb, E2F1, SKP2 and increasing the expression of P53, P21cip1, P27kip1.	dhts	9-13	E2F transcription factor 1	Homo sapiens	215-219
26478521-7	2017	RESULTS: DHTI treatment inhibited the proliferation of 143B cells in a dose- and time-dependent manner through arresting cells in G1 phase by reducing the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6, p-Rb, E2F1, SKP2 and increasing the expression of P53, P21cip1, P27kip1.	dhts	9-13	S-phase kinase associated protein 2	Homo sapiens	221-225
26478521-7	2017	RESULTS: DHTI treatment inhibited the proliferation of 143B cells in a dose- and time-dependent manner through arresting cells in G1 phase by reducing the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6, p-Rb, E2F1, SKP2 and increasing the expression of P53, P21cip1, P27kip1.	dhts	9-13	tumor protein p53	Homo sapiens	259-262
26478521-7	2017	RESULTS: DHTI treatment inhibited the proliferation of 143B cells in a dose- and time-dependent manner through arresting cells in G1 phase by reducing the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6, p-Rb, E2F1, SKP2 and increasing the expression of P53, P21cip1, P27kip1.	dhts	9-13	cyclin dependent kinase inhibitor 1A	Homo sapiens	264-271
26478521-7	2017	RESULTS: DHTI treatment inhibited the proliferation of 143B cells in a dose- and time-dependent manner through arresting cells in G1 phase by reducing the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6, p-Rb, E2F1, SKP2 and increasing the expression of P53, P21cip1, P27kip1.	dhts	9-13	cyclin dependent kinase inhibitor 1B	Homo sapiens	273-280
26478521-8	2017	In addition, DHTI induced apoptosis of 143B cells through caspase pathways to activate caspase-3, caspase-8, caspase-9, Bax, and PARP cleavage but reduce the expression of Bcl-2.	dhts	13-17	caspase 8	Homo sapiens	58-65
26478521-8	2017	In addition, DHTI induced apoptosis of 143B cells through caspase pathways to activate caspase-3, caspase-8, caspase-9, Bax, and PARP cleavage but reduce the expression of Bcl-2.	dhts	13-17	caspase 3	Homo sapiens	87-96
26478521-8	2017	In addition, DHTI induced apoptosis of 143B cells through caspase pathways to activate caspase-3, caspase-8, caspase-9, Bax, and PARP cleavage but reduce the expression of Bcl-2.	dhts	13-17	caspase 8	Homo sapiens	98-107
26478521-8	2017	In addition, DHTI induced apoptosis of 143B cells through caspase pathways to activate caspase-3, caspase-8, caspase-9, Bax, and PARP cleavage but reduce the expression of Bcl-2.	dhts	13-17	caspase 9	Homo sapiens	109-118
26478521-8	2017	In addition, DHTI induced apoptosis of 143B cells through caspase pathways to activate caspase-3, caspase-8, caspase-9, Bax, and PARP cleavage but reduce the expression of Bcl-2.	dhts	13-17	BCL2 associated X, apoptosis regulator	Homo sapiens	120-123
26478521-8	2017	In addition, DHTI induced apoptosis of 143B cells through caspase pathways to activate caspase-3, caspase-8, caspase-9, Bax, and PARP cleavage but reduce the expression of Bcl-2.	dhts	13-17	collagen type XI alpha 2 chain	Homo sapiens	129-133
26478521-8	2017	In addition, DHTI induced apoptosis of 143B cells through caspase pathways to activate caspase-3, caspase-8, caspase-9, Bax, and PARP cleavage but reduce the expression of Bcl-2.	dhts	13-17	BCL2 apoptosis regulator	Homo sapiens	172-177
26478521-9	2017	Furthermore, DHTI treatment attenuated cell migration by down-regulating adhesion molecules VCAM-1 and ICAM-1.	dhts	13-17	vascular cell adhesion molecule 1	Homo sapiens	92-98
26478521-9	2017	Furthermore, DHTI treatment attenuated cell migration by down-regulating adhesion molecules VCAM-1 and ICAM-1.	dhts	13-17	intercellular adhesion molecule 1	Homo sapiens	103-109
27891092-0	2016	Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-Deficient Mice: Role of NOX4/NF-kappaB Mediated Lectin-Like Oxidized LDL Receptor-1 (LOX-1) of the Endothelium.	dhts	0-19	apolipoprotein E	Mus musculus	50-54
27891092-0	2016	Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-Deficient Mice: Role of NOX4/NF-kappaB Mediated Lectin-Like Oxidized LDL Receptor-1 (LOX-1) of the Endothelium.	dhts	0-19	NADPH oxidase 4	Mus musculus	79-83
27891092-0	2016	Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-Deficient Mice: Role of NOX4/NF-kappaB Mediated Lectin-Like Oxidized LDL Receptor-1 (LOX-1) of the Endothelium.	dhts	0-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	84-93
27891092-0	2016	Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-Deficient Mice: Role of NOX4/NF-kappaB Mediated Lectin-Like Oxidized LDL Receptor-1 (LOX-1) of the Endothelium.	dhts	0-19	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	103-138
27891092-0	2016	Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-Deficient Mice: Role of NOX4/NF-kappaB Mediated Lectin-Like Oxidized LDL Receptor-1 (LOX-1) of the Endothelium.	dhts	0-19	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	140-145
26553968-3	2015	We identified the low molecular weight compound 15,16-dihydrotanshinone-I (DHTS), well known in traditional Chinese medicine practice, through a validated high throughput screening on a set of anti-inflammatory agents for its ability to prevent HuR:RNA complex formation.	dhts	48-73	ELAV like RNA binding protein 1	Homo sapiens	245-248
26553968-3	2015	We identified the low molecular weight compound 15,16-dihydrotanshinone-I (DHTS), well known in traditional Chinese medicine practice, through a validated high throughput screening on a set of anti-inflammatory agents for its ability to prevent HuR:RNA complex formation.	dhts	75-79	ELAV like RNA binding protein 1	Homo sapiens	245-248
26553968-4	2015	We found that DHTS interferes with the association step between HuR and the RNA with an equilibrium dissociation constant in the nanomolar range in vitro (Ki = 3.74 +- 1.63 nM).	dhts	14-18	ELAV like RNA binding protein 1	Homo sapiens	64-67
26553968-5	2015	In breast cancer cell lines, short term exposure to DHTS influences mRNA stability and translational efficiency of TNF in a HuR-dependent manner and also other functional readouts of its post-transcriptional control, such as the stability of selected pre-mRNAs.	dhts	52-56	tumor necrosis factor	Homo sapiens	115-118
26553968-5	2015	In breast cancer cell lines, short term exposure to DHTS influences mRNA stability and translational efficiency of TNF in a HuR-dependent manner and also other functional readouts of its post-transcriptional control, such as the stability of selected pre-mRNAs.	dhts	52-56	ELAV like RNA binding protein 1	Homo sapiens	124-127
26553968-6	2015	Importantly, we show that migration and sensitivity of breast cancer cells to DHTS are modulated by HuR expression, indicating that HuR is among the preferential intracellular targets of DHTS.	dhts	78-82	ELAV like RNA binding protein 1	Homo sapiens	100-103
26553968-6	2015	Importantly, we show that migration and sensitivity of breast cancer cells to DHTS are modulated by HuR expression, indicating that HuR is among the preferential intracellular targets of DHTS.	dhts	78-82	ELAV like RNA binding protein 1	Homo sapiens	132-135
26553968-6	2015	Importantly, we show that migration and sensitivity of breast cancer cells to DHTS are modulated by HuR expression, indicating that HuR is among the preferential intracellular targets of DHTS.	dhts	187-191	ELAV like RNA binding protein 1	Homo sapiens	100-103
26553968-6	2015	Importantly, we show that migration and sensitivity of breast cancer cells to DHTS are modulated by HuR expression, indicating that HuR is among the preferential intracellular targets of DHTS.	dhts	187-191	ELAV like RNA binding protein 1	Homo sapiens	132-135
26553968-7	2015	Here, we disclose a previously unrecognized molecular mechanism exerted by DHTS, opening new perspectives to therapeutically target the HuR mediated, post-transcriptional control in inflammation and cancer cells.	dhts	75-79	ELAV like RNA binding protein 1	Homo sapiens	136-139
26287183-3	2015	We found that treatment with 1.5 mug/mL DHTS increased proapoptotic Bax and Bad protein expressions and activated caspases-3, -8, and -9, thus leading to poly ADP ribose polymerase (PARP) cleavage and resulting in cell apoptosis.	dhts	40-44	BCL2 associated X, apoptosis regulator	Homo sapiens	68-71
26282490-0	2015	Dihydrotanshinone I inhibits the translational expression of hypoxia-inducible factor-1alpha.	dhts	0-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-92
26282490-4	2015	We here demonstrated the effect of DHTS on hypoxia-inducible factor-1 (HIF-1) activation.	dhts	35-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-69
26282490-4	2015	We here demonstrated the effect of DHTS on hypoxia-inducible factor-1 (HIF-1) activation.	dhts	35-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-76
26282490-5	2015	DHTS dose-dependently decreased the hypoxia-induced accumulation and activation of HIF-1alpha protein.	dhts	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
26282490-6	2015	Further analysis revealed that DHTS inhibited HIF-1alpha protein synthesis, without affecting the expression level of HIF-1alpha mRNA or degradation of HIF-1alpha protein.	dhts	31-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56
26282490-8	2015	Furthermore, DHTS prevented hypoxia-induced expression of HIF-1 target genes and flow cytometric analysis indicated that DHTS induced G1 phase arrest in HeLa cell.	dhts	13-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-63
26282490-9	2015	In vivo studies further confirmed the inhibitory effect of DHTS on the expression of HIF-1alpha proteins, leading to a decrease in growth of HeLa cells in a xenograft tumor model.	dhts	59-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-95
26282490-10	2015	These results show that DHTS inhibited HIF-1alpha protein synthesis by downregulating the mTOR/p70S6K/4E-BP1 and MEK/ERK pathways.	dhts	24-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-49
26282490-10	2015	These results show that DHTS inhibited HIF-1alpha protein synthesis by downregulating the mTOR/p70S6K/4E-BP1 and MEK/ERK pathways.	dhts	24-28	mechanistic target of rapamycin kinase	Homo sapiens	90-94
26282490-10	2015	These results show that DHTS inhibited HIF-1alpha protein synthesis by downregulating the mTOR/p70S6K/4E-BP1 and MEK/ERK pathways.	dhts	24-28	ribosomal protein S6 kinase B1	Homo sapiens	95-101
26282490-10	2015	These results show that DHTS inhibited HIF-1alpha protein synthesis by downregulating the mTOR/p70S6K/4E-BP1 and MEK/ERK pathways.	dhts	24-28	mitogen-activated protein kinase kinase 7	Homo sapiens	113-116
26282490-10	2015	These results show that DHTS inhibited HIF-1alpha protein synthesis by downregulating the mTOR/p70S6K/4E-BP1 and MEK/ERK pathways.	dhts	24-28	mitogen-activated protein kinase 1	Homo sapiens	117-120
26282490-11	2015	These conclusions suggest that DHTS is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity.	dhts	31-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-70
26283590-2	2015	We identified dihydrotanshinone I as an inhibitor of NF-kappaB activation through our research on Salvia miltiorrhiza Bunge.	dhts	14-33	nuclear factor kappa B subunit 1	Homo sapiens	53-62
26283590-3	2015	In this study, we found that dihydrotanshinone I significantly inhibited the expression of NF-kappaB reporter gene induced by TNF-alpha in a dose-dependent manner.	dhts	29-48	nuclear factor kappa B subunit 1	Homo sapiens	91-100
26283590-3	2015	In this study, we found that dihydrotanshinone I significantly inhibited the expression of NF-kappaB reporter gene induced by TNF-alpha in a dose-dependent manner.	dhts	29-48	tumor necrosis factor	Homo sapiens	126-135
26283590-4	2015	And dihydrotanshinone I also inhibited TNF-alpha induced phosphorylation and degradation of IkappaBalpha, phosphorylation and nuclear translocation of p65.	dhts	4-23	tumor necrosis factor	Homo sapiens	39-48
26283590-4	2015	And dihydrotanshinone I also inhibited TNF-alpha induced phosphorylation and degradation of IkappaBalpha, phosphorylation and nuclear translocation of p65.	dhts	4-23	NFKB inhibitor alpha	Homo sapiens	92-104
26283590-4	2015	And dihydrotanshinone I also inhibited TNF-alpha induced phosphorylation and degradation of IkappaBalpha, phosphorylation and nuclear translocation of p65.	dhts	4-23	RELA proto-oncogene, NF-kB subunit	Homo sapiens	151-154
26283590-6	2015	We also demonstrated that dihydrotanshinone I potentiated TNF-alpha-induced apoptosis.	dhts	26-45	tumor necrosis factor	Homo sapiens	58-67
26283590-7	2015	Moreover, dihydrotanshinone I significantly impaired activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38 and stress-activated protein kinase/c-Jun NH2-terminal kinase (JNK/SAPK).	dhts	10-29	mitogen-activated protein kinase 1	Homo sapiens	67-108
26283590-7	2015	Moreover, dihydrotanshinone I significantly impaired activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38 and stress-activated protein kinase/c-Jun NH2-terminal kinase (JNK/SAPK).	dhts	10-29	mitogen-activated protein kinase 3	Homo sapiens	110-116
26283590-7	2015	Moreover, dihydrotanshinone I significantly impaired activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38 and stress-activated protein kinase/c-Jun NH2-terminal kinase (JNK/SAPK).	dhts	10-29	mitogen-activated protein kinase 1	Homo sapiens	119-122
26283590-7	2015	Moreover, dihydrotanshinone I significantly impaired activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38 and stress-activated protein kinase/c-Jun NH2-terminal kinase (JNK/SAPK).	dhts	10-29	mitogen-activated protein kinase 8	Homo sapiens	186-194
26283590-8	2015	In vivo studies demonstrated that dihydrotanshinone I suppressed the growth of HeLa cells in a xenograft tumor model, which could be correlated with its modulation of TNF-alpha production.	dhts	34-53	tumor necrosis factor	Homo sapiens	167-176
26283590-9	2015	Taken together, dihydrotanshinone I could be a valuable candidate for the intervention of NF-kappaB-dependent pathological conditions such as inflammation and cancer.	dhts	16-35	nuclear factor kappa B subunit 1	Homo sapiens	90-99
26287183-3	2015	We found that treatment with 1.5 mug/mL DHTS increased proapoptotic Bax and Bad protein expressions and activated caspases-3, -8, and -9, thus leading to poly ADP ribose polymerase (PARP) cleavage and resulting in cell apoptosis.	dhts	40-44	caspase 3	Homo sapiens	114-136
26287183-3	2015	We found that treatment with 1.5 mug/mL DHTS increased proapoptotic Bax and Bad protein expressions and activated caspases-3, -8, and -9, thus leading to poly ADP ribose polymerase (PARP) cleavage and resulting in cell apoptosis.	dhts	40-44	poly(ADP-ribose) polymerase 1	Homo sapiens	154-180
26287183-3	2015	We found that treatment with 1.5 mug/mL DHTS increased proapoptotic Bax and Bad protein expressions and activated caspases-3, -8, and -9, thus leading to poly ADP ribose polymerase (PARP) cleavage and resulting in cell apoptosis.	dhts	40-44	poly(ADP-ribose) polymerase 1	Homo sapiens	182-186
26287183-4	2015	DHTS induced sustained c-Jun N-terminal kinase (JNK) phosphorylation and Fas ligand (FasL) expression.	dhts	0-4	mitogen-activated protein kinase 8	Homo sapiens	23-46
26287183-4	2015	DHTS induced sustained c-Jun N-terminal kinase (JNK) phosphorylation and Fas ligand (FasL) expression.	dhts	0-4	mitogen-activated protein kinase 8	Homo sapiens	48-51
26287183-4	2015	DHTS induced sustained c-Jun N-terminal kinase (JNK) phosphorylation and Fas ligand (FasL) expression.	dhts	0-4	Fas ligand	Homo sapiens	73-83
26287183-4	2015	DHTS induced sustained c-Jun N-terminal kinase (JNK) phosphorylation and Fas ligand (FasL) expression.	dhts	0-4	Fas ligand	Homo sapiens	85-89
26287183-5	2015	The anti-Fas blocking antibody reversed the DHTS-induced cell death, and the JNK-specific inhibitor, SP600125, inhibited DHTS-induced caspase-3, -8, -9, and PARP cleavage.	dhts	121-125	mitogen-activated protein kinase 8	Homo sapiens	77-80
26287183-5	2015	The anti-Fas blocking antibody reversed the DHTS-induced cell death, and the JNK-specific inhibitor, SP600125, inhibited DHTS-induced caspase-3, -8, -9, and PARP cleavage.	dhts	121-125	caspase 3	Homo sapiens	134-151
26287183-5	2015	The anti-Fas blocking antibody reversed the DHTS-induced cell death, and the JNK-specific inhibitor, SP600125, inhibited DHTS-induced caspase-3, -8, -9, and PARP cleavage.	dhts	121-125	poly(ADP-ribose) polymerase 1	Homo sapiens	157-161
26287183-7	2015	Taken together, these results suggest that DHTS can induce HL-60 cell apoptosis in vitro and inhibit HL-60 cell growth in vivo; the underlying mechanisms might be mediated through activation of the JNK and FasL signal pathways.	dhts	43-47	mitogen-activated protein kinase 8	Homo sapiens	198-201
26287183-7	2015	Taken together, these results suggest that DHTS can induce HL-60 cell apoptosis in vitro and inhibit HL-60 cell growth in vivo; the underlying mechanisms might be mediated through activation of the JNK and FasL signal pathways.	dhts	43-47	Fas ligand	Homo sapiens	206-210
25917838-0	2015	15,16-Dihydrotanshinone I suppresses IgE-Ag stimulated mouse bone marrow-derived mast cell activation by inhibiting Syk kinase.	dhts	0-25	spleen tyrosine kinase	Mus musculus	116-119
25917838-3	2015	AIM OF THE STUDY: The aim of this study was to evaluate the anti-allergic inflammatory effects of DHT-I on degranulation and on the generation of eicosanoids, such as, prostaglandin D2 (PGD2) and leukotriene C4 (LTC4), in IgE/Ag-stimulated bone marrow-derived mast cells (BMMCs).	dhts	98-103	prostaglandin D2 synthase (brain)	Mus musculus	168-184
24900610-0	2013	Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility.	dhts	50-69	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-40
24040835-0	2013	The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.	dhts	20-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-136
24900610-4	2013	Structures of recombinant human acetylcholinesterase in complex with the natural product inhibitors dihydrotanshinone I and territrem B reveal dihydrotanshinone I binding that is specific to only the peripheral site and territrem B binding that spans both sites and distorts the protein backbone in the peripheral site.	dhts	100-119	acetylcholinesterase (Cartwright blood group)	Homo sapiens	32-52
23871989-7	2013	DHTS induced a selective cytotoxicity and apoptosis in both HCT116 p53(-/-) and HCT116 p53(+/+) colon cancer cells.	dhts	0-4	tumor protein p53	Homo sapiens	67-70
23871989-7	2013	DHTS induced a selective cytotoxicity and apoptosis in both HCT116 p53(-/-) and HCT116 p53(+/+) colon cancer cells.	dhts	0-4	tumor protein p53	Homo sapiens	87-90
23871989-13	2013	SIGNIFICANCE: We report for the first time that DHTS induces apoptosis in colon cancer cells through a p53-independent pathway.	dhts	48-52	tumor protein p53	Homo sapiens	103-106
17869226-10	2007	The fact that DHTS-induced apoptosis could be blocked by pretreating cells with pan-caspase inhibitor confirmed that it is mediated through activation of the caspase-3-dependent pathway.	dhts	14-18	caspase 3	Homo sapiens	158-167
24223062-7	2013	The in vitro study showed that dihydrotanshinone I in the extract could inhibit CYP3A, while tanshinone IIA and cryptotanshinone could induce CYP3A.	dhts	31-50	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	80-85
21787715-7	2011	Our preliminary studies demonstrated that RSM ethanol extract, total tanshinones, tanshinone I and dihydrotanshinone I had remarkable inhibition effects on acetylcholinesterase in vitro.	dhts	99-118	acetylcholinesterase	Rattus norvegicus	156-176
19218247-4	2009	Herein we demonstrate for the first time that human AKR1C enzymes (AKR1C1-4) are able to reduce conjugated steroids such as Dht-17beta-glucuronide (DhtG), Dht-17beta-sulfate (DhtS), and Tib-17beta-sulfate (TibS).	dhts	175-179	aldo-keto reductase family 1 member C1	Homo sapiens	67-75
19218247-6	2009	The product profile of the reduction of each steroid conjugate by the individual AKR1C isoform was similar to that of the corresponding free steroid except for the reduction of DhtG catalyzed by AKR1C2, where a complete inversion in stereochemical preference to 3beta-reduction (with DhtG) from 3alpha-reduction (with Dht and DhtS) was observed.	dhts	326-330	aldo-keto reductase family 1 member C2	Homo sapiens	195-201
17869226-5	2007	When analyzing the expression of cell cycle-related proteins, we found that DHTS reduced cyclin D1, cyclin D3, cyclin E, and CDK4 expression, and increased CDK inhibitor p27 expression in a dose-dependent manner.	dhts	76-80	cyclin D1	Homo sapiens	89-98
23898083-0	2013	15,16-Dihydrotanshinone I-induced apoptosis in human colorectal cancer cells: involvement of ATF3.	dhts	0-25	activating transcription factor 3	Homo sapiens	93-97
23898083-3	2013	Activating transcription factor (ATF)-3, a basic leucine zipper-type transcription factor, was found to be predominantly up-regulated in DHTS-treated SW480 and SW620 cells.	dhts	137-141	activating transcription factor 3	Homo sapiens	0-39
23898083-5	2013	Overexpression of ATF3 resulted in a significant augmentation of DHTS-induced apoptosis of SW480 cells, but resistance to DHTS-induced apoptosis of SW620 cells.	dhts	65-69	activating transcription factor 3	Homo sapiens	18-22
23898083-5	2013	Overexpression of ATF3 resulted in a significant augmentation of DHTS-induced apoptosis of SW480 cells, but resistance to DHTS-induced apoptosis of SW620 cells.	dhts	122-126	activating transcription factor 3	Homo sapiens	18-22
23898083-7	2013	In addition, ATF3 has a dual role in DHTS-induced apoptosis, depending on the degree of malignancy of colorectal cancer.	dhts	37-41	activating transcription factor 3	Homo sapiens	13-17
21274285-4	2011	DHTS was able to induce ER stress as evidenced by the upregulation of glucose regulation protein 78 (GRP78/Bip) and CAAT/enhancer binding protein homologous protein/growth arrest- and DNA damage-inducible gene 153 (CHOP/GADD153), as well as increases in phosphorylated eukaryotic initiation factor 2alpha (eIF2alpha), c-jun N-terminal kinase (JNK), and X-box-binding protein 1 (XBP1) mRNA splicing forms.	dhts	0-4	heat shock protein family A (Hsp70) member 5	Homo sapiens	101-106
21274285-4	2011	DHTS was able to induce ER stress as evidenced by the upregulation of glucose regulation protein 78 (GRP78/Bip) and CAAT/enhancer binding protein homologous protein/growth arrest- and DNA damage-inducible gene 153 (CHOP/GADD153), as well as increases in phosphorylated eukaryotic initiation factor 2alpha (eIF2alpha), c-jun N-terminal kinase (JNK), and X-box-binding protein 1 (XBP1) mRNA splicing forms.	dhts	0-4	heat shock protein family A (Hsp70) member 5	Homo sapiens	107-110
21274285-4	2011	DHTS was able to induce ER stress as evidenced by the upregulation of glucose regulation protein 78 (GRP78/Bip) and CAAT/enhancer binding protein homologous protein/growth arrest- and DNA damage-inducible gene 153 (CHOP/GADD153), as well as increases in phosphorylated eukaryotic initiation factor 2alpha (eIF2alpha), c-jun N-terminal kinase (JNK), and X-box-binding protein 1 (XBP1) mRNA splicing forms.	dhts	0-4	DNA damage inducible transcript 3	Homo sapiens	215-219
21274285-4	2011	DHTS was able to induce ER stress as evidenced by the upregulation of glucose regulation protein 78 (GRP78/Bip) and CAAT/enhancer binding protein homologous protein/growth arrest- and DNA damage-inducible gene 153 (CHOP/GADD153), as well as increases in phosphorylated eukaryotic initiation factor 2alpha (eIF2alpha), c-jun N-terminal kinase (JNK), and X-box-binding protein 1 (XBP1) mRNA splicing forms.	dhts	0-4	DNA damage inducible transcript 3	Homo sapiens	220-227
21274285-4	2011	DHTS was able to induce ER stress as evidenced by the upregulation of glucose regulation protein 78 (GRP78/Bip) and CAAT/enhancer binding protein homologous protein/growth arrest- and DNA damage-inducible gene 153 (CHOP/GADD153), as well as increases in phosphorylated eukaryotic initiation factor 2alpha (eIF2alpha), c-jun N-terminal kinase (JNK), and X-box-binding protein 1 (XBP1) mRNA splicing forms.	dhts	0-4	eukaryotic translation initiation factor 2A	Homo sapiens	306-315
21274285-4	2011	DHTS was able to induce ER stress as evidenced by the upregulation of glucose regulation protein 78 (GRP78/Bip) and CAAT/enhancer binding protein homologous protein/growth arrest- and DNA damage-inducible gene 153 (CHOP/GADD153), as well as increases in phosphorylated eukaryotic initiation factor 2alpha (eIF2alpha), c-jun N-terminal kinase (JNK), and X-box-binding protein 1 (XBP1) mRNA splicing forms.	dhts	0-4	mitogen-activated protein kinase 8	Homo sapiens	318-341
21274285-4	2011	DHTS was able to induce ER stress as evidenced by the upregulation of glucose regulation protein 78 (GRP78/Bip) and CAAT/enhancer binding protein homologous protein/growth arrest- and DNA damage-inducible gene 153 (CHOP/GADD153), as well as increases in phosphorylated eukaryotic initiation factor 2alpha (eIF2alpha), c-jun N-terminal kinase (JNK), and X-box-binding protein 1 (XBP1) mRNA splicing forms.	dhts	0-4	mitogen-activated protein kinase 8	Homo sapiens	343-346
21274285-4	2011	DHTS was able to induce ER stress as evidenced by the upregulation of glucose regulation protein 78 (GRP78/Bip) and CAAT/enhancer binding protein homologous protein/growth arrest- and DNA damage-inducible gene 153 (CHOP/GADD153), as well as increases in phosphorylated eukaryotic initiation factor 2alpha (eIF2alpha), c-jun N-terminal kinase (JNK), and X-box-binding protein 1 (XBP1) mRNA splicing forms.	dhts	0-4	X-box binding protein 1	Homo sapiens	353-376
21274285-4	2011	DHTS was able to induce ER stress as evidenced by the upregulation of glucose regulation protein 78 (GRP78/Bip) and CAAT/enhancer binding protein homologous protein/growth arrest- and DNA damage-inducible gene 153 (CHOP/GADD153), as well as increases in phosphorylated eukaryotic initiation factor 2alpha (eIF2alpha), c-jun N-terminal kinase (JNK), and X-box-binding protein 1 (XBP1) mRNA splicing forms.	dhts	0-4	X-box binding protein 1	Homo sapiens	378-382
21274285-5	2011	DHTS treatment also caused significant accumulation of polyubiquitinated proteins and hypoxia-inducible factor (HIF)-1alpha, indicating that DHTS might be a proteasome inhibitor that is known to induce ER stress or enhance apoptosis caused by the classic ER stress-dependent mechanism.	dhts	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-123
21274285-5	2011	DHTS treatment also caused significant accumulation of polyubiquitinated proteins and hypoxia-inducible factor (HIF)-1alpha, indicating that DHTS might be a proteasome inhibitor that is known to induce ER stress or enhance apoptosis caused by the classic ER stress-dependent mechanism.	dhts	141-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-123
21219824-6	2011	CONCLUSIONS: All of the four Tanshinones have proliferation inhibitory effects on SPC-A-1 cell line, among which the Dihydrotanshinone I is the most active one, followed by Tanshinone I, Tanshinone IIA and Cryptotanshinone subsequently.	dhts	117-136	proline rich protein gene cluster	Homo sapiens	82-85
20380878-5	2010	Here, we report that the lipophilic component, 15,16-dihydrotanshinone I (DHTH) from danshen potently antagonized both mineralocorticoid and glucocorticoid receptors, and efficiently inhibited the expression of their target genes like Na(+)/K(+) ATPase, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK).	dhts	47-72	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	254-275
20380878-5	2010	Here, we report that the lipophilic component, 15,16-dihydrotanshinone I (DHTH) from danshen potently antagonized both mineralocorticoid and glucocorticoid receptors, and efficiently inhibited the expression of their target genes like Na(+)/K(+) ATPase, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK).	dhts	47-72	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	277-283
20380878-5	2010	Here, we report that the lipophilic component, 15,16-dihydrotanshinone I (DHTH) from danshen potently antagonized both mineralocorticoid and glucocorticoid receptors, and efficiently inhibited the expression of their target genes like Na(+)/K(+) ATPase, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK).	dhts	47-72	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	290-323
20380878-5	2010	Here, we report that the lipophilic component, 15,16-dihydrotanshinone I (DHTH) from danshen potently antagonized both mineralocorticoid and glucocorticoid receptors, and efficiently inhibited the expression of their target genes like Na(+)/K(+) ATPase, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK).	dhts	47-72	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	325-330
20380878-5	2010	Here, we report that the lipophilic component, 15,16-dihydrotanshinone I (DHTH) from danshen potently antagonized both mineralocorticoid and glucocorticoid receptors, and efficiently inhibited the expression of their target genes like Na(+)/K(+) ATPase, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK).	dhts	74-78	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	254-275
20380878-5	2010	Here, we report that the lipophilic component, 15,16-dihydrotanshinone I (DHTH) from danshen potently antagonized both mineralocorticoid and glucocorticoid receptors, and efficiently inhibited the expression of their target genes like Na(+)/K(+) ATPase, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK).	dhts	74-78	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	277-283
20380878-5	2010	Here, we report that the lipophilic component, 15,16-dihydrotanshinone I (DHTH) from danshen potently antagonized both mineralocorticoid and glucocorticoid receptors, and efficiently inhibited the expression of their target genes like Na(+)/K(+) ATPase, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK).	dhts	74-78	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	290-323
20380878-5	2010	Here, we report that the lipophilic component, 15,16-dihydrotanshinone I (DHTH) from danshen potently antagonized both mineralocorticoid and glucocorticoid receptors, and efficiently inhibited the expression of their target genes like Na(+)/K(+) ATPase, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK).	dhts	74-78	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	325-330
20380878-6	2010	In addition, DHTH increased AMPKalpha phosphorylation and regulated its downstream pathways, including increasing acetyl-CoA carboxylase (ACC) phosphorylation, inhibiting transducer of regulated CREB activity 2 (TORC2) translocation and promoting glucose uptake.	dhts	13-17	CREB regulated transcription coactivator 2	Homo sapiens	212-217
18563358-4	2008	The electrophoretic mobility shift assay showed that cryptotanshinone and 15,16-dihydrotanshinone I also inhibited the activation of the transcription factors, such as nuclear transcription factor-kappaB and activator protein-1.	dhts	74-99	jun proto-oncogene	Mus musculus	208-227
17869226-5	2007	When analyzing the expression of cell cycle-related proteins, we found that DHTS reduced cyclin D1, cyclin D3, cyclin E, and CDK4 expression, and increased CDK inhibitor p27 expression in a dose-dependent manner.	dhts	76-80	cyclin D3	Homo sapiens	100-109
17869226-5	2007	When analyzing the expression of cell cycle-related proteins, we found that DHTS reduced cyclin D1, cyclin D3, cyclin E, and CDK4 expression, and increased CDK inhibitor p27 expression in a dose-dependent manner.	dhts	76-80	cyclin dependent kinase 4	Homo sapiens	125-129
17869226-5	2007	When analyzing the expression of cell cycle-related proteins, we found that DHTS reduced cyclin D1, cyclin D3, cyclin E, and CDK4 expression, and increased CDK inhibitor p27 expression in a dose-dependent manner.	dhts	76-80	interferon alpha inducible protein 27	Homo sapiens	170-173
17869226-6	2007	In addition, DHTS inhibited the kinase activities of CDK2 and CDK4 by an immunocomplex kinase assay.	dhts	13-17	cyclin dependent kinase 2	Homo sapiens	53-57
17869226-6	2007	In addition, DHTS inhibited the kinase activities of CDK2 and CDK4 by an immunocomplex kinase assay.	dhts	13-17	cyclin dependent kinase 4	Homo sapiens	62-66
17869226-8	2007	We found that DHTS decreased the anti-apoptotic protein Bcl-xL level and increased the loss of mitochondria membrane potential and the amount of cytochrome c released.	dhts	14-18	BCL2 like 1	Homo sapiens	56-62
17869226-8	2007	We found that DHTS decreased the anti-apoptotic protein Bcl-xL level and increased the loss of mitochondria membrane potential and the amount of cytochrome c released.	dhts	14-18	cytochrome c, somatic	Homo sapiens	145-157
17869226-9	2007	Moreover, DHTS activated caspase-9, caspase-3, and caspase-7 and caused cell apoptosis.	dhts	10-14	caspase 9	Homo sapiens	25-34
17869226-9	2007	Moreover, DHTS activated caspase-9, caspase-3, and caspase-7 and caused cell apoptosis.	dhts	10-14	caspase 3	Homo sapiens	36-45
17869226-9	2007	Moreover, DHTS activated caspase-9, caspase-3, and caspase-7 and caused cell apoptosis.	dhts	10-14	caspase 7	Homo sapiens	51-60
17714702-13	2007	In addition, cryptotanshinone and 15, 16-dihydrotanshinone I were found to have an inhibitory effect on acetylcholinesterase in vitro with IC(50) values 82 and 25 microM, respectively.	dhts	34-60	acetylcholinesterase	Mus musculus	104-124