PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29575058-1	2018	The absolute configurations of the diastereomers of novel amino acid ester derivatives of 2,3-substituted isoindolinones, which are known as apoptosis activators due to their ability to inhibit the MDM2-p53 PPI, were assigned using NMR and computational methods.	2,3-substituted isoindolinones	90-120	MDM2 proto-oncogene	Homo sapiens	198-202
29575058-1	2018	The absolute configurations of the diastereomers of novel amino acid ester derivatives of 2,3-substituted isoindolinones, which are known as apoptosis activators due to their ability to inhibit the MDM2-p53 PPI, were assigned using NMR and computational methods.	2,3-substituted isoindolinones	90-120	tumor protein p53	Homo sapiens	203-206
29089230-1	2017	A series of novel amino acid ester derivatives of 2,3-substituted isoindolinones was synthesized and evaluated for p53-mediated apoptotic activity.	2,3-substituted isoindolinones	50-80	tumor protein p53	Homo sapiens	115-118
29089230-2	2017	The rationale for augmentation of the target activity of 2,3-substituted isoindolinones was based on the introduction of new fragments in the structure of the inhibitor that would provide additional binding sites in the hydrophobic cavity of MDM2.	2,3-substituted isoindolinones	57-87	MDM2 proto-oncogene	Homo sapiens	242-246