PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 22369721-10 2012 The transfected cells with transporters were used to investigate drug-drug interactions (DDIs) between JBP485 and other substrates (cephalexin or lisinopril) of PEPT1 and PEPT2. Cephalexin 132-142 solute carrier family 15 member 1 Homo sapiens 161-166 20980636-2 2010 In this study, we first investigated the effects of LP consumption on plasma amino acid concentrations and PepT1-mediated absorption of cephalexin in the small intestine of wild-type (WT) mice and interleukin-10 knockout (IL-10(-/-)) mice, a model of spontaneous colitis. Cephalexin 136-146 solute carrier family 15 (oligopeptide transporter), member 1 Mus musculus 107-112 22263689-3 2012 Over 60 candidate structures containing various dipeptide sequences were obtained with high purity, and screened in a PEPT1 overexpressing cell model for their abilities to compete with the known ligand cephalexin. Cephalexin 203-213 solute carrier family 15 member 1 Homo sapiens 118-123 21999946-6 2011 Inhibition of pH-dependent glycylsarcosine uptake by low concentration of cephalexin, which is a beta-lactam antibiotics recognized by Pepts, indicates a predominant role of high affinity type Pept2, but not low affinity type Pept1, in the PTCs. Cephalexin 74-84 solute carrier family 15 member 1 Rattus norvegicus 226-231 20884889-5 2010 Oligopeptide transporter 1 (PepT1)-mediated transepithelial transport was evaluated by measuring the plasma cephalexin concentration. Cephalexin 108-118 solute carrier family 15 (oligopeptide transporter), member 1 Mus musculus 28-33 20884889-8 2010 PepT1 expression was increased, accompanied with an enhanced cephalexin transport. Cephalexin 61-71 solute carrier family 15 (oligopeptide transporter), member 1 Mus musculus 0-5 22943882-5 2012 The favorable effect of the local transplantation of culture expanded (cEx)-BM CD34(+) cells on rat unhealing fractures was equivalent or higher than that of nonexpanded (fresh) BM CD34(+) cells exhibiting sufficient therapeutic outcome with frequent vasculogenic/osteogenic differentiation of transplanted cEx-BM CD34(+) cells and fresh BM CD34(+) cells as well as intrinsic enhancement of angiogenesis/osteogenesis at the treated fracture sites. Cephalexin 71-74 CD34 molecule Rattus norvegicus 79-83 21497459-10 2011 The results provide a strong indication that cephalexin selects for E. coli producing plasmid-borne CMY-2 beta-lactamase. Cephalexin 45-55 CMY-2 beta-lactamase Escherichia coli 100-120 21035968-8 2011 Four novel variants (bla(OKP-A-13), bla(OKP-A-14), bla(OKP-A-15), and bla(OKP-A-16)) were identified among the 10 OKP beta-lactamase-producing K. pneumoniae isolates resistant to ampicillin, amoxicillin, oxacillin, cefalexin, and cefadroxil. Cephalexin 215-224 TEM beta-lactamase Klebsiella pneumoniae 21-24 21553652-1 2011 The characteristics of intestinal absorption of mizoribine and cephalexin, that are mediated by concentrative nucleoside transporters (CNTs) and PEPT1, respectively, was examined in lipopolysaccharide (LPS)-treated rats. Cephalexin 63-73 solute carrier family 15 member 1 Rattus norvegicus 145-150 21084767-0 2011 Effects of sodium bicarbonate and ammonium chloride pre-treatments on PEPT2 (SLC15A2) mediated renal clearance of cephalexin in healthy subjects. Cephalexin 114-124 solute carrier family 15 member 2 Homo sapiens 70-75 21084767-0 2011 Effects of sodium bicarbonate and ammonium chloride pre-treatments on PEPT2 (SLC15A2) mediated renal clearance of cephalexin in healthy subjects. Cephalexin 114-124 solute carrier family 15 member 2 Homo sapiens 77-84 20980636-4 2010 LP consumption (10(9) colony-forming units/0.5 mL) delivered by gavage once per day for 4 wk increased the total plasma amino acid concentration and the concentration of plasma cephalexin through enhancement of PepT1-mediated uptake in LP treated IL-10(-/-) mice compared with IL-10(-/-) mice. Cephalexin 177-187 solute carrier family 15 (oligopeptide transporter), member 1 Mus musculus 211-216 20211890-1 2010 Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime. Cephalexin 151-161 beta-lactamase Staphylococcus aureus 82-96 20484555-0 2010 Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. Cephalexin 52-62 solute carrier family 47, member 1 Mus musculus 66-71 20484555-1 2010 Multidrug and toxin extrusion 1 (MATE1/solute carrier 47A1) mediates the transport of not only organic cations but also zwitterions such as cephalexin. Cephalexin 140-150 solute carrier family 47, member 1 Mus musculus 33-38 20484555-2 2010 However, the contribution of MATE1 to tubular secretion of cephalexin in vivo has not been elucidated. Cephalexin 59-69 solute carrier family 47, member 1 Mus musculus 29-34 20484555-4 2010 Cephalexin uptake by human MATE1-expressing human embryonic kidney 293 cells exhibited saturable kinetics (K(m) = 5.9 +/- 0.5 mM) and a bell-shaped pH profile with a maximum at pH 7.0. Cephalexin 0-10 solute carrier family 47 member 1 Homo sapiens 27-32 20484555-5 2010 We confirmed that mouse MATE1 also transported cephalexin. Cephalexin 47-57 solute carrier family 47, member 1 Mus musculus 24-29 20484555-6 2010 After a single intravenous administration of cephalexin (5 mg/kg), Mate1(-/-) mice showed higher plasma concentrations of cephalexin than wild-type [Mate1(+/+)] mice. Cephalexin 45-55 solute carrier family 47, member 1 Mus musculus 67-72 20484555-6 2010 After a single intravenous administration of cephalexin (5 mg/kg), Mate1(-/-) mice showed higher plasma concentrations of cephalexin than wild-type [Mate1(+/+)] mice. Cephalexin 45-55 solute carrier family 47, member 1 Mus musculus 149-154 20484555-6 2010 After a single intravenous administration of cephalexin (5 mg/kg), Mate1(-/-) mice showed higher plasma concentrations of cephalexin than wild-type [Mate1(+/+)] mice. Cephalexin 122-132 solute carrier family 47, member 1 Mus musculus 67-72 20484555-8 2010 The renal clearance of cephalexin in Mate1(-/-) mice was approximately 60% of that in Mate1(+/+) mice and seemed to be near the creatinine clearance. Cephalexin 23-33 solute carrier family 47, member 1 Mus musculus 37-42 20484555-10 2010 In this study, we demonstrated that MATE1 is responsible for renal tubular secretion of a zwitterionic substrate cephalexin in vivo. Cephalexin 113-123 solute carrier family 47, member 1 Mus musculus 36-41 20546869-9 2010 iNOS protein expression and NO production were also reduced by CEX treatment. Cephalexin 63-66 nitric oxide synthase 2, inducible Mus musculus 0-4 20211890-1 2010 Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime. Cephalexin 151-161 beta-lactamase Staphylococcus aureus 98-101 20211890-1 2010 Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime. Cephalexin 151-161 beta-lactamase Staphylococcus aureus 170-173 18766334-0 2009 Interethnic differences of PEPT2 (SLC15A2) polymorphism distribution and associations with cephalexin pharmacokinetics in healthy Asian subjects. Cephalexin 91-101 solute carrier family 15 member 2 Homo sapiens 27-32 19652390-2 2009 Although the L-diastereomer of the beta-lactam antibiotic cephalexin (L-cephalexin) is likely to be transported by PEPT1, there has been no direct demonstration of PEPT1-mediated L-cephalexin transport. Cephalexin 58-68 solute carrier family 15 member 1 Homo sapiens 115-120 19652390-2 2009 Although the L-diastereomer of the beta-lactam antibiotic cephalexin (L-cephalexin) is likely to be transported by PEPT1, there has been no direct demonstration of PEPT1-mediated L-cephalexin transport. Cephalexin 70-82 solute carrier family 15 member 1 Homo sapiens 115-120 19652390-3 2009 Indeed, after the incubation with L-cephalexin, the intact form of L-cephalexin has not been identified inside vesicles/proteoliposomes prepared from brush border membrane of intestinal epithelial cells or cultured cell lines exogenously transfected with PEPT1 gene. Cephalexin 67-79 solute carrier family 15 member 1 Homo sapiens 255-260 19652390-4 2009 Thus, it appears that L-cephalexin is rapidly metabolized by PEPT1 or PEPT1-associated proteins. Cephalexin 22-34 solute carrier family 15 member 1 Homo sapiens 61-66 19652390-4 2009 Thus, it appears that L-cephalexin is rapidly metabolized by PEPT1 or PEPT1-associated proteins. Cephalexin 22-34 solute carrier family 15 member 1 Homo sapiens 70-75 19652390-5 2009 Here, we attempted to verify whether L-cephalexin is transported by PEPT1 and whether it is hydrolyzed by PEPT1 itself, by using budded baculovirus expressing PEPT1 protein. Cephalexin 37-49 solute carrier family 15 member 1 Homo sapiens 68-73 19652390-6 2009 Marked uptake of L-cephalexin in PEPT1-expressing budded baculovirus, compared with wild-type virus, indicated that L-cephalexin is a substrate for PEPT1. Cephalexin 17-29 solute carrier family 15 member 1 Homo sapiens 33-38 19652390-6 2009 Marked uptake of L-cephalexin in PEPT1-expressing budded baculovirus, compared with wild-type virus, indicated that L-cephalexin is a substrate for PEPT1. Cephalexin 17-29 solute carrier family 15 member 1 Homo sapiens 148-153 19652390-6 2009 Marked uptake of L-cephalexin in PEPT1-expressing budded baculovirus, compared with wild-type virus, indicated that L-cephalexin is a substrate for PEPT1. Cephalexin 116-128 solute carrier family 15 member 1 Homo sapiens 33-38 19652390-6 2009 Marked uptake of L-cephalexin in PEPT1-expressing budded baculovirus, compared with wild-type virus, indicated that L-cephalexin is a substrate for PEPT1. Cephalexin 116-128 solute carrier family 15 member 1 Homo sapiens 148-153 19652390-8 2009 Thus, L-cephalexin is transported by PEPT1 itself. Cephalexin 6-18 solute carrier family 15 member 1 Homo sapiens 37-42 19652390-9 2009 Upon the transport of both L- and D-cephalexin by PEPT1, dose-dependent membrane depolarization was observed; the EC(50) values of 0.18 and 2.9 mM, respectively, indicate that the affinity of L-cephalexin for PEPT1-mediated transport is much higher than that of the D-diastereomer. Cephalexin 192-204 solute carrier family 15 member 1 Homo sapiens 50-55 19652390-9 2009 Upon the transport of both L- and D-cephalexin by PEPT1, dose-dependent membrane depolarization was observed; the EC(50) values of 0.18 and 2.9 mM, respectively, indicate that the affinity of L-cephalexin for PEPT1-mediated transport is much higher than that of the D-diastereomer. Cephalexin 192-204 solute carrier family 15 member 1 Homo sapiens 209-214 19652390-11 2009 We conclude that L-cephalexin is transported by PEPT1 with high affinity, but is not metabolized by PEPT1 itself. Cephalexin 17-29 solute carrier family 15 member 1 Homo sapiens 48-53 18766334-12 2009 The association between the PEPT2 haplotype and cephalexin pharmacokinetics could not be confirmed, and future studies under better controlled conditions are needed. Cephalexin 48-58 solute carrier family 15 member 2 Homo sapiens 28-33 18784906-0 2009 Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats. Cephalexin 68-78 solute carrier family 15 member 1 Rattus norvegicus 27-32 18784906-2 2009 The objective of this study is to quantitatively evaluate the contribution of PEPT1 to oral absorption of cephalexin, a typical substrate for PEPT1, in rats. Cephalexin 106-116 solute carrier family 15 member 1 Rattus norvegicus 78-83 18784906-2 2009 The objective of this study is to quantitatively evaluate the contribution of PEPT1 to oral absorption of cephalexin, a typical substrate for PEPT1, in rats. Cephalexin 106-116 solute carrier family 15 member 1 Rattus norvegicus 142-147 18784906-3 2009 MATERIALS AND METHODS: The absorbability of cephalexin via PEPT1 or passive diffusion was assessed in five intestinal segments by utilizing glycyl-proline as a competitive inhibitor by in-situ closed loop method. Cephalexin 44-54 solute carrier family 15 member 1 Rattus norvegicus 59-64 18784906-8 2009 Plasma concentration-time profile of cephalexin was successfully predicted and the substantial contribution of PEPT1 to the oral absorption was calculated to be from 46% to 60% of total absorption. Cephalexin 37-47 solute carrier family 15 member 1 Rattus norvegicus 111-116 18784906-9 2009 Simulation study indicated that 83% bioavailability would be expected for cephalexin even though PEPT1 does not function. Cephalexin 74-84 solute carrier family 15 member 1 Rattus norvegicus 97-102 18784906-10 2009 CONCLUSIONS: PEPT1 substantially contributes to oral absorption of cephalexin, around a half of total absorption. Cephalexin 67-77 solute carrier family 15 member 1 Rattus norvegicus 13-18 18784906-11 2009 However, the function of PEPT1 can be compensated by passive diffusion for cephalexin. Cephalexin 75-85 solute carrier family 15 member 1 Rattus norvegicus 25-30 18322073-3 2008 GI absorption of cephalexin, a substrate of PEPT1, after p.o. Cephalexin 17-27 solute carrier family 15 (oligopeptide transporter), member 1 Mus musculus 44-49 17329854-6 2007 These findings indicate that capsaicin affects both transcellular and paracellular pathways of intestinal cephalexin absorption by interacting with the TRP cation channels in intestinal tissues, in which capsaicin seems to change the transport activity of H+/peptide co-transporter 1 (PEPT1), and to a lesser degree, it seems to alter the paracellular permeability of the intestinal epithelia. Cephalexin 106-116 solute carrier family 15 member 1 Rattus norvegicus 256-283 17372819-1 2007 The effect of colitis induced with dextran sodium sulfate (DSS) in rats on the bioavailability of drugs transported by the oligopeptide transporter PepT-1 was analyzed by studying the pharmacokinetics of PepT-1 substrates: cephalexin and valacyclovir, the prodrug of antiviral acyclovir. Cephalexin 223-233 solute carrier family 15 member 1 Rattus norvegicus 148-154 17891554-6 2008 Cefadroxil, cefazolin, cefmetazole, cefoperazone, cefsulodin, and cephalexin, though not cefotaxime or ceftriaxone, were also substrates of Oatp2. Cephalexin 66-76 solute carrier organic anion transporter family, member 1a4 Rattus norvegicus 140-145 17854115-1 2007 This study dealt with the potential of MEKC with LIF detection involving derivatization with sulfoindocyanine succinimidyl ester (Cy5) for the separation and determination of beta-lactam antibiotics (ampicillin, amoxicillin, cephradine, and cephalexin) in environmental water samples. Cephalexin 241-251 LIF interleukin 6 family cytokine Homo sapiens 49-52 17509534-7 2007 Although their affinity for hMATE1 and hMATE2-K was similar, the zwitterionic cephalexin and cephradine were revealed to be specific substrates of hMATE1, but not of hMATE2-K. Levofloxacin and ciprofloxacin were not transported, but were demonstrated to be potent inhibitors of these transporters. Cephalexin 78-88 solute carrier family 47 member 1 Homo sapiens 147-153 17142565-0 2007 Functional expression of stereoselective metabolism of cephalexin by exogenous transfection of oligopeptide transporter PEPT1. Cephalexin 55-65 solute carrier family 15 member 1 Homo sapiens 120-125 17142565-1 2007 Gastrointestinal absorption of the beta-lactam antibiotic cephalexin (CEX) is highly stereoselective: l- and d-CEX are both taken up by intestinal epithelial cells through the brush-border membrane, most likely via oligopeptide transporter PEPT1, but l-CEX is not found in serum or urine after administration p.o. Cephalexin 58-68 solute carrier family 15 member 1 Homo sapiens 240-245 17142565-1 2007 Gastrointestinal absorption of the beta-lactam antibiotic cephalexin (CEX) is highly stereoselective: l- and d-CEX are both taken up by intestinal epithelial cells through the brush-border membrane, most likely via oligopeptide transporter PEPT1, but l-CEX is not found in serum or urine after administration p.o. Cephalexin 70-73 solute carrier family 15 member 1 Homo sapiens 240-245 17142565-3 2007 We examined the contribution of PEPT1 to the stereoselective uptake and metabolism of CEX. Cephalexin 86-89 solute carrier family 15 member 1 Homo sapiens 32-37 17142565-4 2007 We observed stereoselective metabolism of CEX after exogenous transfection of PEPT1 alone into mammalian cell lines: l-CEX, but not d-CEX, was metabolized to 7-aminodesacetoxycephalosporanic acid (7-ADCA) in HeLa and human embryonic kidney 293 cells stably and transiently expressing human PEPT1, respectively, whereas such metabolism was minor in cells expressing the vector alone. Cephalexin 42-45 solute carrier family 15 member 1 Homo sapiens 78-83 17142565-4 2007 We observed stereoselective metabolism of CEX after exogenous transfection of PEPT1 alone into mammalian cell lines: l-CEX, but not d-CEX, was metabolized to 7-aminodesacetoxycephalosporanic acid (7-ADCA) in HeLa and human embryonic kidney 293 cells stably and transiently expressing human PEPT1, respectively, whereas such metabolism was minor in cells expressing the vector alone. Cephalexin 42-45 solute carrier family 15 member 1 Homo sapiens 290-295 17142565-9 2007 The present findings show that stereoselectivity in CEX absorption can be fully explained in terms of PEPT1, implying that the l-CEX hydrolase is PEPT1 itself or is induced by PEPT1. Cephalexin 52-55 solute carrier family 15 member 1 Homo sapiens 102-107 17142565-9 2007 The present findings show that stereoselectivity in CEX absorption can be fully explained in terms of PEPT1, implying that the l-CEX hydrolase is PEPT1 itself or is induced by PEPT1. Cephalexin 52-55 solute carrier family 15 member 1 Homo sapiens 146-151 17142565-9 2007 The present findings show that stereoselectivity in CEX absorption can be fully explained in terms of PEPT1, implying that the l-CEX hydrolase is PEPT1 itself or is induced by PEPT1. Cephalexin 52-55 solute carrier family 15 member 1 Homo sapiens 146-151 16634069-9 2006 PepT1-mediated transport of R1518 was supported by results of competitive transport studies of R1518 with the PepT1 substrates enalapril, Gly-Sar, valganciclovir, and cephalexin. Cephalexin 167-177 solute carrier family 15 member 1 Homo sapiens 0-5 17727793-3 2007 The purpose of this study was to determine if the hPEPT1 substrate, cephalexin, inhibits the absorption of the N-formylated peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine ("fMLP"), thereby preventing hyperpermeability in Caco2 cells. Cephalexin 68-78 solute carrier family 15 member 1 Homo sapiens 50-56 17727793-3 2007 The purpose of this study was to determine if the hPEPT1 substrate, cephalexin, inhibits the absorption of the N-formylated peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine ("fMLP"), thereby preventing hyperpermeability in Caco2 cells. Cephalexin 68-78 formyl peptide receptor 1 Homo sapiens 181-185 17727793-8 2007 RESULTS: Cephalexin 10 mM significantly reduced fMLP permeability (p=0.007). Cephalexin 9-19 formyl peptide receptor 1 Homo sapiens 48-52 17727793-9 2007 Monolayer integrity (as indicated mannitol permeability) was decreased in cultures treated with inflammatory cytokines and fMLP, an effect that was attenuated by cephalexin (p<0.01). Cephalexin 162-172 formyl peptide receptor 1 Homo sapiens 123-127 17727793-10 2007 CONCLUSION: Cephalexin inhibits fMLP transport across cultured intestinal monolayers, and partially attenuates PMN-induced intestinal hyperpermeability. Cephalexin 12-22 formyl peptide receptor 1 Homo sapiens 32-36 17009119-5 2006 Inhibition of PepT1 by Gly-Gly completely abolished cephalexin absorption from the colon of resection rats. Cephalexin 52-62 solute carrier family 15 member 1 Rattus norvegicus 14-19 16850272-7 2006 MATE1 transported not only organic cations such as cimetidine and metformin but also the zwitterionic compound cephalexin. Cephalexin 111-121 solute carrier family 47 member 1 Rattus norvegicus 0-5 16850272-10 2006 CONCLUSIONS: These findings indicate that MATE1 is expressed in the renal proximal tubules and can mediate the transport of various organic cations and cephalexin using an oppositely directed H+ gradient. Cephalexin 152-162 solute carrier family 47 member 1 Rattus norvegicus 42-47 15567297-4 2005 Cefadroxil, cefaclor, cyclacillin, cephradine, cephalexin and moxalactam were recognized by PEPT2 with very high affinity comparable to that of natural dipeptides (K(i)=3-100microM). Cephalexin 47-57 solute carrier family 15 member 2 Homo sapiens 92-97 16627568-7 2006 Our results indicate that the substrate selectivity of hPEPT1 is: Gly-Sar > NAAG, delta-ALA, bestatin > cefadroxil, cephalexin > ampicillin, amoxicillin. Cephalexin 122-132 solute carrier family 15 member 1 Homo sapiens 55-61 14600416-3 2003 Absorption clearance (CLabs) decreased in the presence of glycylsarcosine, cephalexin or cephradine, substrates for H+/oligopeptide cotransporter (PEPT1). Cephalexin 75-85 solute carrier family 15 member 1 Rattus norvegicus 147-152 15056866-2 2004 In the present study, we investigated the effects of progesterone and its related compounds on the uptake of cephalexin, a typical PEPT1 substrate, using the human intestinal cell line Caco-2. Cephalexin 109-119 solute carrier family 15 member 1 Homo sapiens 131-136 15056866-12 2004 Therefore the quantitative decrease in PEPT1 density is considered to be one cause of the decrease in cephalexin uptake with progesterone and norethisterone treatments. Cephalexin 102-112 solute carrier family 15 member 1 Homo sapiens 39-44 14987855-9 2004 Moreover, cephalexin appears to behave as monoanionic tridentate ligand coordinating the tin(IV) atom through ester-type carboxylate, as well as through beta-lactam carbonyl oxygen atoms and the amino nitrogen donor atoms in Alk(2)SnOHceph(. Cephalexin 10-20 ALK receptor tyrosine kinase Homo sapiens 225-228 14987855-13 2004 )H(2)O derivatives are concerned, cephalexin coordinated the Alk(3)Sn moiety through the carboxylate acting as a bridging bidentate monoanionic group. Cephalexin 34-44 ALK receptor tyrosine kinase Homo sapiens 61-64 14706815-0 2004 Effect of insulin on cephalexin uptake and transepithelial transport in the human intestinal cell line Caco-2. Cephalexin 21-31 insulin Homo sapiens 10-17 14706815-1 2004 We investigated whether cephalexin transport in Caco-2 cells is regulated by insulin. Cephalexin 24-34 insulin Homo sapiens 77-84 14706815-3 2004 Cephalexin uptake was significantly increased by the insulin pretreatment. Cephalexin 0-10 insulin Homo sapiens 53-60 14706815-4 2004 Insulin significantly increased cephalexin saturable uptake, but had no significant effect on the non-saturable one. Cephalexin 32-42 insulin Homo sapiens 0-7 14706815-6 2004 The enhancement of cephalexin uptake by the insulin pretreatment was inhibited by genistein, a tyrosine kinase inhibitor, and colchicine, an agent that disrupts protein translocation. Cephalexin 19-29 insulin Homo sapiens 44-51 14706815-7 2004 Apical-to-basolateral transport of cephalexin has increased by the insulin pretreatment at the apical side and long-term insulin pretreatment at the basolateral side. Cephalexin 35-45 insulin Homo sapiens 67-74 14706815-7 2004 Apical-to-basolateral transport of cephalexin has increased by the insulin pretreatment at the apical side and long-term insulin pretreatment at the basolateral side. Cephalexin 35-45 insulin Homo sapiens 121-128 15244036-2 2002 Absorption clearance (CLabs) decreased in the presence of glycylsarcosine, cephalexin or cephradine, substrates for H+/oligopeptide cotransporter (PEPT1). Cephalexin 75-85 solute carrier family 15 member 1 Rattus norvegicus 147-152 12821497-3 2003 Coadministration of the human peptide transporter 1 (hPEPT1) substrates valacyclovir and cephalexin minimally reduced the acyclovir AUC. Cephalexin 89-99 solute carrier family 15 member 1 Homo sapiens 53-59 12679938-2 2003 METHODS: A human intestinal cell monolayer (Caco-2) was used as the in vitro model of human small intestine and cephalexin as the model substrate for dipeptide transporter (PepT1). Cephalexin 112-122 solute carrier family 15 member 1 Homo sapiens 173-178 12356285-3 2002 These molecules have both peptide bonds and aromatic rings, and are similar in structure to cephalexin and cephadroxil, which are transported by PEPT1. Cephalexin 92-102 solute carrier family 15 member 1 Homo sapiens 145-150 10900220-1 2000 Di- and tripeptides, as well as peptidomimetic drugs such as cephalexin (CFX), are absorbed by enterocytes via the oligopeptide transporter PepT1. Cephalexin 61-71 solute carrier family 15 member 1 Homo sapiens 140-145 15618660-3 2002 The expression of rOAT1 significantly stimulated the uptake of cefazolin, cefotiam and cephalexin into oocytes, but not of cefoperazone. Cephalexin 87-97 solute carrier family 22 member 6 Rattus norvegicus 18-23 11714740-0 2001 PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine. Cephalexin 54-64 solute carrier family 15 member 1 Homo sapiens 0-5 11117234-12 2000 These findings provide evidence that the change in the total amount of CEX is an index of the active transport function, probably by intestinal peptide transporter (PEPT1), and is well reflected by histopathological changes in the intestinal mucosa induced by MTX. Cephalexin 71-74 solute carrier family 15 member 1 Rattus norvegicus 165-170 15618660-4 2002 The inhibition constants of these cephalosporins to rOAT1-mediated p-aminohippurate (PAH) uptake were 72 microM for cefazolin, 298 microM for cefoperazone, 718 microM for cefotiam and 6 mM for cephalexin. Cephalexin 193-203 solute carrier family 22 member 6 Rattus norvegicus 52-57 11602669-2 2001 In this study, we determined the correlation between PEPT1 protein expression and the permeability of cephalexin, a substrate of PEPT1, in human PEPT1 (hPEPT1)-overexpressed Caco-2 cells (Caco-2/hPEPT1 cells) and rat jejunum. Cephalexin 102-112 solute carrier family 15 member 1 Homo sapiens 53-58 11602669-2 2001 In this study, we determined the correlation between PEPT1 protein expression and the permeability of cephalexin, a substrate of PEPT1, in human PEPT1 (hPEPT1)-overexpressed Caco-2 cells (Caco-2/hPEPT1 cells) and rat jejunum. Cephalexin 102-112 solute carrier family 15 member 1 Homo sapiens 129-134 11602669-2 2001 In this study, we determined the correlation between PEPT1 protein expression and the permeability of cephalexin, a substrate of PEPT1, in human PEPT1 (hPEPT1)-overexpressed Caco-2 cells (Caco-2/hPEPT1 cells) and rat jejunum. Cephalexin 102-112 solute carrier family 15 member 1 Homo sapiens 129-134 11602669-2 2001 In this study, we determined the correlation between PEPT1 protein expression and the permeability of cephalexin, a substrate of PEPT1, in human PEPT1 (hPEPT1)-overexpressed Caco-2 cells (Caco-2/hPEPT1 cells) and rat jejunum. Cephalexin 102-112 solute carrier family 15 member 1 Homo sapiens 152-158 11602669-2 2001 In this study, we determined the correlation between PEPT1 protein expression and the permeability of cephalexin, a substrate of PEPT1, in human PEPT1 (hPEPT1)-overexpressed Caco-2 cells (Caco-2/hPEPT1 cells) and rat jejunum. Cephalexin 102-112 solute carrier family 15 member 1 Homo sapiens 195-201 11602669-6 2001 In Caco-2/hPEPT1 cells, an excellent correlation was observed between cephalexin uptake and hPEPT1 expression (R2 = 0.96, P < 0.005). Cephalexin 70-80 solute carrier family 15 member 1 Homo sapiens 10-16 11602669-6 2001 In Caco-2/hPEPT1 cells, an excellent correlation was observed between cephalexin uptake and hPEPT1 expression (R2 = 0.96, P < 0.005). Cephalexin 70-80 solute carrier family 15 member 1 Homo sapiens 92-98 11602669-7 2001 This demonstrates that cephalexin uptake is directly proportional to hPEPT1 expression. Cephalexin 23-33 solute carrier family 15 member 1 Homo sapiens 69-75 11602669-10 2001 A very significant correlation between PEPT1 expression and cephalexin permeability with an R2 = 0.63 (P < 0.001) was observed. Cephalexin 60-70 solute carrier family 15 member 1 Homo sapiens 39-44 11602669-11 2001 This indicates that the variation in PEPT1 expression is one of the major factors accounting for variable intestinal cephalexin absorption. Cephalexin 117-127 solute carrier family 15 member 1 Homo sapiens 37-42 11729356-5 2001 METHODS: Balb/c female mice were immunized intraperitoneally with alum and conjugates of different amoxicillins or cephalexins with ovalbumin (OVA). Cephalexin 115-126 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 132-141 7592745-8 1995 Expression of PEPT 1 or PEPT 2 in HeLa cells was found to induce H(+)-coupled cephalexin uptake in these cells. Cephalexin 78-88 solute carrier family 15 member 1 Homo sapiens 14-20 9492022-6 1998 After pertussis toxin treatment (200 ng/ml; 5 h), the peptone- and cephalexin-induced CCK secretion was significantly reduced, suggesting the involvement of pertussis toxin-sensitive heterotrimeric G protein(s) in the secretory activity of STC-1 cells. Cephalexin 67-77 cholecystokinin Rattus norvegicus 86-89 9492022-6 1998 After pertussis toxin treatment (200 ng/ml; 5 h), the peptone- and cephalexin-induced CCK secretion was significantly reduced, suggesting the involvement of pertussis toxin-sensitive heterotrimeric G protein(s) in the secretory activity of STC-1 cells. Cephalexin 67-77 stanniocalcin 1 Rattus norvegicus 240-245 9374833-4 1997 Other beta-lactams, such as cephalexin, cefadroxil, and cephradine (aminocephalosporins), inhibited modestly the PEPT1-mediated glycylsarcosine uptake. Cephalexin 28-38 solute carrier family 15 member 1 Rattus norvegicus 113-118 9374833-6 1997 Comparison of the inhibition constant (Ki) values between cefadroxil and cephalexin suggested that the hydroxyl group at the NH2-terminal phenyl ring increased affinity for both PEPT1 and PEPT2. Cephalexin 73-83 solute carrier family 15 member 1 Rattus norvegicus 178-183 10681320-8 2000 Faropenem transport by Npt1 was significantly inhibited by beta-lactam antibiotics such as benzylpenicillin, ampicillin, cephalexin, and cefazolin to 24.9, 40. Cephalexin 121-131 solute carrier family 17 (sodium phosphate), member 1 Mus musculus 23-27 10411577-3 1999 Penicillin G, carbenicillin, cephaloridine, cephalothin, cefazolin, and cephalexin inhibited [(14)C]PAH uptake via OAT1 in a competitive manner (K(i) = 0.29-2.33 mM). Cephalexin 72-82 solute carrier family 22 member 6 Rattus norvegicus 115-119 7592745-8 1995 Expression of PEPT 1 or PEPT 2 in HeLa cells was found to induce H(+)-coupled cephalexin uptake in these cells. Cephalexin 78-88 solute carrier family 15 member 2 Homo sapiens 24-30 1294622-4 1992 Among the beta-lactams the most active were the cephalosporins (cephalexin, cefamandol, ceftazidin, and a sulbactam-ampicillin combination) in inducing the release of TNF, IL-1 alpha, and IL-6 from monocytes, and releasing IL-4 and IFN-tau from lymphocytes. Cephalexin 64-74 tumor necrosis factor Homo sapiens 167-170 7794953-7 1995 The affinity of the ACE-inhibitors for the intestinal peptide carrier has been evaluated based on their ability to inhibit the transport rate of cephalexin. Cephalexin 145-155 angiotensin I converting enzyme Rattus norvegicus 20-23 2143009-1 1990 The effect of two cephalosporins, cefadroxil and cefalexine, was in vitro studied by using two models of regulation of the IgE production in healthy humans, e.g. the induction of CD23-antigens on B-cells and the IgE synthesis in cell culture supernatants after stimulation by recombinant interleukin-4. Cephalexin 49-59 Fc epsilon receptor II Homo sapiens 179-183 34703227-9 2021 Cex-HSA/DOX/MDR1 siRNA (C-H/D/M) was characterized by dynamic light scattering and transmission electron microscopy. Cephalexin 0-3 ATP binding cassette subfamily B member 1 Homo sapiens 12-16 2099340-9 1990 The reaction of Cep1-2 with cephalexin-HSA was inhibited by cephalexin lysate. Cephalexin 28-38 CDC42 effector protein 1 Homo sapiens 16-20 2099340-10 1990 Cep2-2 and Cep6 were weakly inhibited by the binding to cephalexin-HSA by cephalexin lysate. Cephalexin 56-66 centrosomal protein 250 Homo sapiens 0-4 3488425-6 1986 Against E. coli and K. pneumoniae, the activity of BRL 25000 was superior to that of AMPC and approximately equal to CEX, CDX and CXD but 2-fold less than CCL. Cephalexin 117-120 bromodomain containing 1 Homo sapiens 51-54 34460299-1 2021 Cefalexin is a widely used 1st generation cephalosporin, and resistance in Escherichia coli is caused by Extended-Spectrum (e.g., CTX-M) and AmpC beta-lactamase production and therefore frequently coincides with 3rd generation cephalosporin resistance. Cephalexin 0-9 beta-lactamase Escherichia coli 141-145 34647114-0 2021 QM/MM modeling of class A beta-lactamases reveals distinct acylation pathways for ampicillin and cefalexin. Cephalexin 97-106 amyloid beta precursor protein Homo sapiens 24-30 35433490-11 2022 Results: Irradiated mice treated with OP-C or DXE combined with or without cephalexin significantly reduced mortality in mice and fibrosis levels by 1) reducing the deposition of collagen and accumulation of inflammatory cells and fibroblasts, 2) downgrading levels of the promote-fibrosis cytokine TGF-beta1, and 3) increasing SOD activity in the lung tissue compared with that of irradiated mice without treatment. Cephalexin 75-85 transforming growth factor, beta 1 Mus musculus 299-308 3141170-4 1988 Strains producing TEM-2 and CEP-1 were resistant to LY163892, cefaclor and cephalexin. Cephalexin 75-85 RASD family member 2 Homo sapiens 18-23 3141170-4 1988 Strains producing TEM-2 and CEP-1 were resistant to LY163892, cefaclor and cephalexin. Cephalexin 75-85 centriolin Homo sapiens 28-33 392100-1 1979 Two compounds, analogues of cephalexin with 2- and 4-pyridone groups at C-3, were prepared. Cephalexin 28-38 complement C3 Homo sapiens 72-75 6335045-9 1984 Antibiotic resistance to Ampicillin, Cephaloridine, Cephalexine and Cefazolin observed in receiving strains after conjugation is not only due to beta-lactamase transfer. Cephalexin 52-63 beta-lactamase Escherichia coli 145-159 3892076-10 1985 Against E. coli at an inoculum of 10(8) cells/ml, BRL 25000 showed antibacterial activity next to AMPC and CCL whilst at an inoculum of 10(6) cells/ml, it was inferior in the small MIC range but superior in the large MIC range to AMPC and CEX and was inferior to CCL but superior to CVA. Cephalexin 239-242 bromodomain containing 1 Homo sapiens 50-53 3892076-12 1985 Against P. mirabilis at inoculum sizes of 10(8) and 10(6) cells/ml, BRL 25000 was inferior in the small MIC range but equal or superior in the large MIC range to AMPC, and was superior to CVA and CEX. Cephalexin 196-199 bromodomain containing 1 Homo sapiens 68-71 356181-2 1978 In a prospective study of patients treated with cephalexin or co-trimoxazole, almost all isolated E. coli strains of intermediate susceptibility to ampicillin or cephalosporin (MIC 2-16 microgram/ml) were shown to produce beta-lactamase detectable with a chromogenic cephalosporin substrate, or by the clover-leaf test or the acidimetric method. Cephalexin 48-58 beta-lactamase Escherichia coli 222-236 356181-4 1978 In order to evaluate the clinical significance of this beta-lactamase production, 48 patients with urinary tract infection (UTI) were treated with cephalexin, an antibiotic hydrolysed by the enzyme. Cephalexin 147-157 beta-lactamase Escherichia coli 55-69 29298246-3 2020 METHODS: A local clinical pathway for uncomplicated UTI, introduced in June 2010, recommended empiric treatment with cephalexin, a narrow-spectrum (first-generation) cephalosporin antibiotic. Cephalexin 117-127 alpha-1-microglobulin/bikunin precursor Homo sapiens 52-55 33924433-4 2021 Extended-spectrum beta-lactamase (ESBL)-producing E. coli were isolated on deoxycholate hydrogen sulfide lactose agar, containing cephalexin (50 mug/mL) or cefotaxime (2 mug/mL), and were characterized with antimicrobial susceptibility testing, pulsed-field gel electrophoresis (PFGE), replicon typing, and beta-lactamase typing analyses. Cephalexin 130-140 EsbL Escherichia coli 0-32 32172148-0 2020 Design a new photocatalyst of sea sediment/titanate to remove cephalexin antibiotic from aqueous media in the presence of sonication/ultraviolet/hydrogen peroxide: Pathway and mechanism for degradation. Cephalexin 62-72 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 30-33 32172148-1 2020 The aim of the current study was directed to develop a new sea sediment/titanate photocatalyst to remove cephalexin from aqueous media in the presence of ultraviolet (UV) light, hydrogen peroxide (H2O2), and ultrasonic waves. Cephalexin 105-115 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 59-62 32172148-4 2020 The maximum cephalexin removal (94.71%) was obtained at the furnace temperature of 500 C, the furnace residence time of 2 h, and the sea sediment: titanium ratio of 1:6 (=12 mL TiO2/2 g sea sediment). Cephalexin 12-22 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 134-137 32172148-4 2020 The maximum cephalexin removal (94.71%) was obtained at the furnace temperature of 500 C, the furnace residence time of 2 h, and the sea sediment: titanium ratio of 1:6 (=12 mL TiO2/2 g sea sediment). Cephalexin 12-22 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 187-190 32172148-9 2020 The present investigation showed that the developed technique (sea sediment/titanate-UV-H2O2-ultrasonic) could be used as a promising alternative for attenuating cephalexin from aqueous solutions. Cephalexin 162-172 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 63-66 4199743-1 1973 A comparison has been made of the immunological properties of CEA (carcinoembryonic antigen) and another perchloric acid-soluble macromolecule which occurs in colonic and certain other carcinomata and which is here termed CEX. Cephalexin 222-225 CEA cell adhesion molecule 3 Homo sapiens 62-65 4199743-5 1973 CEX was found in foetal gut, in plasma and associated with CEA in virtually all the tissues and fluids in which the latter occurs; the two appear to go hand-in-hand and no proof was found that CEX is either less or more cancer specific than CEA-it is merely found in greater quantity; neither substance showed absolute cancer specificity. Cephalexin 0-3 CEA cell adhesion molecule 3 Homo sapiens 59-62 4199743-6 1973 The usefulness of a radioimmunoassay for CEX is discussed, and also the possibility of interference by CEX in the radioimmunoassay for CEA. Cephalexin 103-106 CEA cell adhesion molecule 3 Homo sapiens 135-138 31776320-0 2020 Neoadjuvant chemotherapy of capecitabine + epirubicin + cyclophosphamide combination therapy ( "CEX" therapy) for HER-2 negative breast cancer, as retrospective study in our institute. Cephalexin 96-99 erb-b2 receptor tyrosine kinase 2 Homo sapiens 114-119 31776320-1 2020 BACKGROUND: We have modified and performed neoadjuvant chemotherapy (NAC) using capecitabine + epirubicin + cyclophosphamide combination therapy ( "CEX" ) for HER-2 negative breast cancer. Cephalexin 148-151 erb-b2 receptor tyrosine kinase 2 Homo sapiens 159-164 30925667-4 2019 The secondary structure of bovine serum albumin (BSA) was altered by the binding of drugs, like amoxicillin (Amox), cephalexin (Cefa), and azithromycin (Azit). Cephalexin 116-126 albumin Homo sapiens 34-47 31778961-11 2020 Both AEx and CEx increased the expression of liver glucose transporter 2 (GLUT-2) and muscle GLUT-4 with the highest level in CEx rats (P < 0.05). Cephalexin 13-16 solute carrier family 2 member 2 Rattus norvegicus 51-72 31778961-11 2020 Both AEx and CEx increased the expression of liver glucose transporter 2 (GLUT-2) and muscle GLUT-4 with the highest level in CEx rats (P < 0.05). Cephalexin 13-16 solute carrier family 2 member 2 Rattus norvegicus 74-80 31778961-11 2020 Both AEx and CEx increased the expression of liver glucose transporter 2 (GLUT-2) and muscle GLUT-4 with the highest level in CEx rats (P < 0.05). Cephalexin 13-16 solute carrier family 2 member 4 Rattus norvegicus 93-99 31913025-2 2020 Treatment of [Ir(PPh3)3Cl] prepared by a convenient method with Hdpp in the presence of KOtBu under the refluxing mixture solvent toluene/methanol (2:1, v/v) generates the N,N-chelating complex [Ir(K2N,N-dpp)(H)(Cl)(PPh3)2] (3) together with 1 and the N,N-chelating dihydride complex [Ir(K2N,N-dpp)(H)2(PPh3)2] (4). Cephalexin 266-275 protein phosphatase 4 catalytic subunit Homo sapiens 17-21 31913025-2 2020 Treatment of [Ir(PPh3)3Cl] prepared by a convenient method with Hdpp in the presence of KOtBu under the refluxing mixture solvent toluene/methanol (2:1, v/v) generates the N,N-chelating complex [Ir(K2N,N-dpp)(H)(Cl)(PPh3)2] (3) together with 1 and the N,N-chelating dihydride complex [Ir(K2N,N-dpp)(H)2(PPh3)2] (4). Cephalexin 266-275 protein phosphatase 4 catalytic subunit Homo sapiens 216-220 31913025-2 2020 Treatment of [Ir(PPh3)3Cl] prepared by a convenient method with Hdpp in the presence of KOtBu under the refluxing mixture solvent toluene/methanol (2:1, v/v) generates the N,N-chelating complex [Ir(K2N,N-dpp)(H)(Cl)(PPh3)2] (3) together with 1 and the N,N-chelating dihydride complex [Ir(K2N,N-dpp)(H)2(PPh3)2] (4). Cephalexin 266-275 protein phosphatase 4 catalytic subunit Homo sapiens 216-220 31828439-4 2019 The orange emission of the probe, with excitation/emission maxima at 295/590 nm, decreases linearly in the 2.5-50 mug L-1 cephalexin concentration range with a limit of detection (LOD) of 0.81 mug L-1. Cephalexin 122-132 immunoglobulin kappa variable 1-16 Homo sapiens 118-121 31828439-4 2019 The orange emission of the probe, with excitation/emission maxima at 295/590 nm, decreases linearly in the 2.5-50 mug L-1 cephalexin concentration range with a limit of detection (LOD) of 0.81 mug L-1. Cephalexin 122-132 immunoglobulin kappa variable 1-16 Homo sapiens 197-200 29728279-2 2019 Data gathered indicated that caffeine, paracetamol, atenolol, ibuprofen, cephalexin and bisphenol A occur in the mug L-1 range in streams near urban areas. Cephalexin 73-83 immunoglobulin kappa variable 1-16 Homo sapiens 117-120 28976065-2 2018 In the present study, we chose two typical antibiotics cefalexin/cefixime based on their structure, and investigated the interaction of cephalexin/cefixime with bovine serum albumin (BSA) using UV-vis absorption spectra, fluorescence spectroscopy, circular dichroism (CD) spectroscopy and molecular modeling approaches. Cephalexin 136-146 albumin Homo sapiens 168-181 30172043-0 2018 N, Ag co-doped TiO2 mediated modified in-situ dual process (modified photocatalysis and photo-Fenton) in fixed-mode for the degradation of Cephalexin under solar irradiations. Cephalexin 139-149 tiptop Drosophila melanogaster 15-18 30304029-8 2018 In contrast, the phosphorylation levels of AMP-activated protein kinase, ACC, and TBC1D1 (Ser660) were significantly higher in rats in the WEx and CEx groups than the CON group (p < 0.05) but did not differ significantly between rats in the WEx and CEx groups. Cephalexin 147-150 TBC1 domain family member 1 Rattus norvegicus 82-88 27565855-1 2016 Water dispersible, highly efficient nickel doped CdS nanoparticles anchored on graphene nanosheets as a photocatalyst for cephalexin and sulfamethoxazole photodegradation have been prepared in a facile microwave-furnace assisted method. Cephalexin 122-132 CDP-diacylglycerol synthase 1 Homo sapiens 49-52 32104323-1 2017 The aim of this study is to investigate the pharmacokinetics of 5"-valyl-cytarabine hydrochloride (OPC) when co-administered with cephalexin, which are both the substrates of PepT1. Cephalexin 130-140 solute carrier family 15 member 1 Rattus norvegicus 175-180 28576315-3 2017 After the optimization of the experimental conditions, a linear correlation was obtained between the peak height and the molar concentration of cefalexin in the range of 0.5 muM-700 muM, with a limit of detection of 34.74 ng mL-1. Cephalexin 144-153 latexin Homo sapiens 174-177 28576315-3 2017 After the optimization of the experimental conditions, a linear correlation was obtained between the peak height and the molar concentration of cefalexin in the range of 0.5 muM-700 muM, with a limit of detection of 34.74 ng mL-1. Cephalexin 144-153 latexin Homo sapiens 182-185 28576315-3 2017 After the optimization of the experimental conditions, a linear correlation was obtained between the peak height and the molar concentration of cefalexin in the range of 0.5 muM-700 muM, with a limit of detection of 34.74 ng mL-1. Cephalexin 144-153 L1 cell adhesion molecule Mus musculus 225-229 28253390-14 2017 When RFS and survival of the patients were compared within the subgroups defined by cancer steroid hormone receptor status (ER and/or PR positive vs ER and PR negative) and HER2 status (positive vs negative), TX+CEX was more effective than T+CEF in the subset of patients with TNBC (HR, 0.53; 95% CI, 0.31-0.92; P = .02; and HR, 0.55, 95% CI, 0.31-0.96; P = .03; respectively). Cephalexin 212-215 progesterone receptor Homo sapiens 134-136 28253390-14 2017 When RFS and survival of the patients were compared within the subgroups defined by cancer steroid hormone receptor status (ER and/or PR positive vs ER and PR negative) and HER2 status (positive vs negative), TX+CEX was more effective than T+CEF in the subset of patients with TNBC (HR, 0.53; 95% CI, 0.31-0.92; P = .02; and HR, 0.55, 95% CI, 0.31-0.96; P = .03; respectively). Cephalexin 212-215 progesterone receptor Homo sapiens 156-158 28253390-14 2017 When RFS and survival of the patients were compared within the subgroups defined by cancer steroid hormone receptor status (ER and/or PR positive vs ER and PR negative) and HER2 status (positive vs negative), TX+CEX was more effective than T+CEF in the subset of patients with TNBC (HR, 0.53; 95% CI, 0.31-0.92; P = .02; and HR, 0.55, 95% CI, 0.31-0.96; P = .03; respectively). Cephalexin 212-215 erb-b2 receptor tyrosine kinase 2 Homo sapiens 173-177 28368864-5 2017 All ESBL producers were resistant to ampicillin, cephalexin, cefalotin, cefpodoxime, ceftiofur, enrofloxacin, marbofloxacin, and trimethoprim/sulfamethoxazole, but were susceptible to imipenem and amoxicillin/clavulanic acid. Cephalexin 49-59 EsbL Escherichia coli 4-8 24072682-9 2013 H(+):Gly-Sar absorption was completely inhibited by cephalexin (a competitive inhibitor of PepT1) and was activated by GIP. Cephalexin 52-62 solute carrier family 15 (oligopeptide transporter), member 1 Mus musculus 91-96 26511749-9 2016 ESBL-positive organisms were associated with increases in drug resistance, particularly amongst fluoroquinolones, trimethoprim, and cephalexin. Cephalexin 132-142 EsbL Escherichia coli 0-4 26590007-4 2016 In addition, MFLX significantly decreased the cephalexin and valacyclovir uptake in HeLa/PEPT1 cells. Cephalexin 46-56 solute carrier family 15 member 1 Homo sapiens 89-94 26852864-1 2016 We investigated the influence of sweet and umami (savory) tastants on the intestinal absorption of cephalexin (CEX), a substrate of peptide transporter 1 (PEPT1, SLC15A1) in rats. Cephalexin 99-109 solute carrier family 15 member 1 Rattus norvegicus 132-153 26852864-1 2016 We investigated the influence of sweet and umami (savory) tastants on the intestinal absorption of cephalexin (CEX), a substrate of peptide transporter 1 (PEPT1, SLC15A1) in rats. Cephalexin 99-109 solute carrier family 15 member 1 Rattus norvegicus 155-160 26852864-1 2016 We investigated the influence of sweet and umami (savory) tastants on the intestinal absorption of cephalexin (CEX), a substrate of peptide transporter 1 (PEPT1, SLC15A1) in rats. Cephalexin 99-109 solute carrier family 15 member 1 Rattus norvegicus 162-169 26852864-1 2016 We investigated the influence of sweet and umami (savory) tastants on the intestinal absorption of cephalexin (CEX), a substrate of peptide transporter 1 (PEPT1, SLC15A1) in rats. Cephalexin 111-114 solute carrier family 15 member 1 Rattus norvegicus 132-153 26422788-0 2015 Mucin-drugs interaction: The case of theophylline, prednisolone and cephalexin. Cephalexin 68-78 LOC100508689 Homo sapiens 0-5 26422788-1 2015 The binding of mucin with three commercially available drugs (theophylline, cephalexin and prednisolone) belonging to different pharmaceutical classes was investigated. Cephalexin 76-86 LOC100508689 Homo sapiens 15-20 25119667-7 2014 Flux of cephalexin (CFX) across the tissue mounted in Ussing chambers was used as an indicator of PepT-1 activity. Cephalexin 8-18 solute carrier family 15 member 1 Sus scrofa 98-104 27489646-3 2014 And 1 day after starting therapy, the patient developed an extensive erythematous rash accompanied by skin sloughing; 4 days after receiving cephalexin, the patient was directly admitted to the burn intensive care unit and was diagnosed with toxic epidermal necrolysis involving 56% of the total body surface area. Cephalexin 141-151 WD repeat and HMG-box DNA binding protein 1 Homo sapiens 0-5 24360441-1 2014 A fast and effective extraction method has been developed for measuring the residue of cephalosporins (cefalexin, cefazolin, cefoperazone) in milk by using magnetic core-mesoporous shell microspheres with C18-functionalized interior pore-walls (C18-Fe3O4@mSiO2) as adsorbent. Cephalexin 103-112 Bardet-Biedl syndrome 9 Homo sapiens 205-208 25008848-3 2014 The uptake was pH-dependent, being highest at pH 6.0, and was significantly decreased in the presence of PEPT1 inhibitors [glycylsarcosine (Gly-Sar), cephalexin, valaciclovir, glycylglycine, and glycylproline]. Cephalexin 150-160 solute carrier family 15 member 1 Homo sapiens 105-110 23192864-8 2013 The established ruminant MDCKII-ABCG2 cell culture models in conjunction with the H33342 transport assay showed interaction of various drugs such as cefalexin and albendazole with bABCG2, oABCG2 or cABCG2. Cephalexin 149-158 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 32-37 23400747-1 2013 In this study, the authors compared the effects of amlodipine (AML) on the bioavailability of cephalexin (LEX) and cefuroxime axetil (CXM). Cephalexin 94-104 fucosyltransferase 4 Homo sapiens 106-109 22760735-1 2012 Fibrinogen-modified bismuth-gold nanoparticles (Fib-Bi-Au NPs) are prepared and used as enzyme mimics for the H(2)O(2)-mediated reaction with Amplex Red (AR), which is further employed for determining thrombin activity and drug screening. Cephalexin 142-148 fibrinogen beta chain Homo sapiens 0-10 22760735-1 2012 Fibrinogen-modified bismuth-gold nanoparticles (Fib-Bi-Au NPs) are prepared and used as enzyme mimics for the H(2)O(2)-mediated reaction with Amplex Red (AR), which is further employed for determining thrombin activity and drug screening. Cephalexin 142-148 coagulation factor II, thrombin Homo sapiens 201-209