PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35287432-6	2022	First, we report studies of solvent isotope effects for the N202S CYP17A1 mutant in the presence of 17OH-PREG and 17OH-PROG, which suggest that the ferric peroxo species is the predominant catalytically active intermediate in the lyase step.	ferric peroxo	148-161	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	66-73
29758981-6	2018	Adding to a previous study of PREG and 17-OH PREG metabolism, the current work provides definitive evidence for a more facile protonation of the initially formed ferric peroxo-intermediate for 17-OH PROG-bound CYP17A1, compared to the complex with 17-OH PREG.	ferric peroxo	162-175	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	210-217
21894985-5	2011	On the basis of these calculations and extensive analysis of structure-mutagenicity data, we suggest that mutagenic metabolites are generated by ferric peroxo intermediate, (CYP1A2)Fe(III)-OO(-), in a three-step heterolytic mechanism.	ferric peroxo	145-158	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	174-180