PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12271460-2	2002	A functional and cell biological analysis of Kre5p was conducted to further elucidate the role of this diverged protein glucosyltransferase-like protein in beta-1,6-glucan synthesis.	beta-1,6-glucan	156-171	Kre5p	Saccharomyces cerevisiae S288C	45-50
12112232-0	2002	Saccharomyces cerevisiae Big1p, a putative endoplasmic reticulum membrane protein required for normal levels of cell wall beta-1,6-glucan.	beta-1,6-glucan	122-137	Big1p	Saccharomyces cerevisiae S288C	25-30
12112232-1	2002	Deletion of Saccharomyces cerevisiae BIG1 causes an approximately 95% reduction in cell wall beta-1,6-glucan, an essential polymer involved in the cell wall attachment of many surface mannoproteins.	beta-1,6-glucan	93-108	Big1p	Saccharomyces cerevisiae S288C	37-41
12185837-0	2002	Mutations in Fks1p affect the cell wall content of beta-1,3- and beta-1,6-glucan in Saccharomyces cerevisiae.	beta-1,6-glucan	65-80	1,3-beta-D-glucan synthase	Saccharomyces cerevisiae S288C	13-18
12185837-2	2002	Analysis of fks1 delta mutants showed a partial K1 killer toxin-resistant phenotype and a 30% reduction in alkali-soluble beta-1,3-glucan that was accompanied by a modest reduction in beta-1,6-glucan.	beta-1,6-glucan	184-199	1,3-beta-D-glucan synthase	Saccharomyces cerevisiae S288C	12-16
12185837-4	2002	Overexpression of FKS2 suppressed the killer toxin phenotype of fks1 delta mutants, implicating Fks2p in the biosynthesis of the residual beta-1,6-glucan present in fks1 delta cells.	beta-1,6-glucan	138-153	1,3-beta-glucan synthase GSC2	Saccharomyces cerevisiae S288C	18-22
12185837-4	2002	Overexpression of FKS2 suppressed the killer toxin phenotype of fks1 delta mutants, implicating Fks2p in the biosynthesis of the residual beta-1,6-glucan present in fks1 delta cells.	beta-1,6-glucan	138-153	1,3-beta-glucan synthase GSC2	Saccharomyces cerevisiae S288C	96-101
12185837-4	2002	Overexpression of FKS2 suppressed the killer toxin phenotype of fks1 delta mutants, implicating Fks2p in the biosynthesis of the residual beta-1,6-glucan present in fks1 delta cells.	beta-1,6-glucan	138-153	1,3-beta-D-glucan synthase	Saccharomyces cerevisiae S288C	165-169
12185837-8	2002	We analysed Fks1p and Fks2p in beta-1,6-glucan deficient mutants and found that they were mislocalized and that the mutants had reduced in vitro glucan synthase activity, possibly contributing to the observed beta-1,6-glucan defects.	beta-1,6-glucan	31-46	1,3-beta-D-glucan synthase	Saccharomyces cerevisiae S288C	12-17
12185837-8	2002	We analysed Fks1p and Fks2p in beta-1,6-glucan deficient mutants and found that they were mislocalized and that the mutants had reduced in vitro glucan synthase activity, possibly contributing to the observed beta-1,6-glucan defects.	beta-1,6-glucan	31-46	1,3-beta-glucan synthase GSC2	Saccharomyces cerevisiae S288C	22-27
12185837-8	2002	We analysed Fks1p and Fks2p in beta-1,6-glucan deficient mutants and found that they were mislocalized and that the mutants had reduced in vitro glucan synthase activity, possibly contributing to the observed beta-1,6-glucan defects.	beta-1,6-glucan	209-224	1,3-beta-D-glucan synthase	Saccharomyces cerevisiae S288C	12-17
12185837-8	2002	We analysed Fks1p and Fks2p in beta-1,6-glucan deficient mutants and found that they were mislocalized and that the mutants had reduced in vitro glucan synthase activity, possibly contributing to the observed beta-1,6-glucan defects.	beta-1,6-glucan	209-224	1,3-beta-glucan synthase GSC2	Saccharomyces cerevisiae S288C	22-27
11427965-1	2001	The Saccharomyces cerevisiae cwh43-2 mutant, originally isolated for its Calcofluor white hypersensitivity, displays several cell wall defects similar to mutants in the PKC1-MPK1 pathway, including a growth defect and increased release of beta-1,6-glucan and beta-glucosylated proteins into the growth medium at increased temperatures.	beta-1,6-glucan	239-254	Cwh43p	Saccharomyces cerevisiae S288C	29-34
11136466-4	2001	In addition, we found high levels of Cwp1p, which was double-anchored through both the novel alkali-sensitive bond to beta1,3-glucan and the alkali-resistant GPI-derived linkage to beta1,6-glucan.	beta-1,6-glucan	181-195	Cwp1p	Saccharomyces cerevisiae S288C	37-42
10601196-2	1999	It has been postulated that the synthesis of beta1,6-glucan begins in the endoplasmic reticulum with the formation of protein-bound primer structures and that these primer structures are extended in the Golgi complex by two putative glucosyltransferases that are functionally redundant, Kre6 and Skn1.	beta-1,6-glucan	45-59	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	287-291
10601196-2	1999	It has been postulated that the synthesis of beta1,6-glucan begins in the endoplasmic reticulum with the formation of protein-bound primer structures and that these primer structures are extended in the Golgi complex by two putative glucosyltransferases that are functionally redundant, Kre6 and Skn1.	beta-1,6-glucan	45-59	beta-glucan synthesis-associated protein SKN1	Saccharomyces cerevisiae S288C	296-300
10601196-4	1999	We have reinvestigated the role of Kre6 and Skn1 in the biogenesis of beta1,6-glucan.	beta-1,6-glucan	70-84	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	35-39
10601196-4	1999	We have reinvestigated the role of Kre6 and Skn1 in the biogenesis of beta1,6-glucan.	beta-1,6-glucan	70-84	beta-glucan synthesis-associated protein SKN1	Saccharomyces cerevisiae S288C	44-48
10209754-0	1999	The contribution of the O-glycosylated protein Pir2p/Hsp150 to the construction of the yeast cell wall in wild-type cells and beta 1,6-glucan-deficient mutants.	beta-1,6-glucan	126-141	heat shock protein HSP150	Saccharomyces cerevisiae S288C	47-52
10209754-0	1999	The contribution of the O-glycosylated protein Pir2p/Hsp150 to the construction of the yeast cell wall in wild-type cells and beta 1,6-glucan-deficient mutants.	beta-1,6-glucan	126-141	heat shock protein HSP150	Saccharomyces cerevisiae S288C	53-59
9748432-0	1998	Isolation of Candida glabrata homologs of the Saccharomyces cerevisiae KRE9 and KNH1 genes and their involvement in cell wall beta-1,6-glucan synthesis.	beta-1,6-glucan	126-141	Kre9p	Saccharomyces cerevisiae S288C	71-75
9748432-0	1998	Isolation of Candida glabrata homologs of the Saccharomyces cerevisiae KRE9 and KNH1 genes and their involvement in cell wall beta-1,6-glucan synthesis.	beta-1,6-glucan	126-141	Knh1p	Saccharomyces cerevisiae S288C	80-84
9763440-0	1998	The role of glucosidase I (Cwh41p) in the biosynthesis of cell wall beta-1,6-glucan is indirect.	beta-1,6-glucan	68-83	mannosyl-oligosaccharide glucosidase	Saccharomyces cerevisiae S288C	27-33
9763440-1	1998	CWH41, a gene involved in the assembly of cell wall beta-1,6-glucan, has recently been shown to be the structural gene for Saccharomyces cerevisiae glucosidase I that is responsible for initiating the trimming of terminal alpha-1,2-glucose residue in the N-glycan processing pathway.	beta-1,6-glucan	52-67	mannosyl-oligosaccharide glucosidase	Saccharomyces cerevisiae S288C	0-5
9763440-4	1998	The strong genetic interactions of CWH41 with KRE6 and KRE1, two other genes involved in the beta-1,6-glucan biosynthetic pathway, disappear in the absence of dolichol-P-glucose synthase (alg5Delta).	beta-1,6-glucan	93-108	mannosyl-oligosaccharide glucosidase	Saccharomyces cerevisiae S288C	35-40
9763440-4	1998	The strong genetic interactions of CWH41 with KRE6 and KRE1, two other genes involved in the beta-1,6-glucan biosynthetic pathway, disappear in the absence of dolichol-P-glucose synthase (alg5Delta).	beta-1,6-glucan	93-108	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	46-50
9763440-4	1998	The strong genetic interactions of CWH41 with KRE6 and KRE1, two other genes involved in the beta-1,6-glucan biosynthetic pathway, disappear in the absence of dolichol-P-glucose synthase (alg5Delta).	beta-1,6-glucan	93-108	Kre1p	Saccharomyces cerevisiae S288C	55-59
9763440-8	1998	These results demonstrate that the role of glucosidase I (Cwh41p) in the biosynthesis of cell wall beta-1,6-glucan is indirect and that dolichol-P-glucose is not an intermediate in this pathway.	beta-1,6-glucan	99-114	mannosyl-oligosaccharide glucosidase	Saccharomyces cerevisiae S288C	58-64
9707560-0	1998	The Candida albicans KRE9 gene is required for cell wall beta-1, 6-glucan synthesis and is essential for growth on glucose.	beta-1,6-glucan	57-73	Kre9p	Saccharomyces cerevisiae S288C	21-25
9707560-1	1998	We have isolated CaKRE9, a gene from Candida albicans, that is a functional homologue of the Saccharomyces cerevisiae KRE9 gene involved in beta-1,6-glucan synthesis.	beta-1,6-glucan	140-155	Kre9p	Saccharomyces cerevisiae S288C	19-23
9611196-6	1998	We also observe a approximately 30% decrease in beta-1,6-glucan upon disruption of the CNE1 gene, a phenotype that is additive with other beta-1,6-glucan synthetic mutants.	beta-1,6-glucan	48-63	calnexin	Saccharomyces cerevisiae S288C	87-91
9611196-6	1998	We also observe a approximately 30% decrease in beta-1,6-glucan upon disruption of the CNE1 gene, a phenotype that is additive with other beta-1,6-glucan synthetic mutants.	beta-1,6-glucan	138-153	calnexin	Saccharomyces cerevisiae S288C	87-91
9363789-4	1997	However, we found that beta-1,3-glucanase solubilized Tir1p/Srp1p from the cell wall and the purified Tir1p/Srp1p reacted with antiserum to beta-1,6-glucan and contained glucose.	beta-1,6-glucan	140-155	GPI-anchored mannoprotein	Saccharomyces cerevisiae S288C	102-107
9363789-4	1997	However, we found that beta-1,3-glucanase solubilized Tir1p/Srp1p from the cell wall and the purified Tir1p/Srp1p reacted with antiserum to beta-1,6-glucan and contained glucose.	beta-1,6-glucan	140-155	karyopherin alpha	Saccharomyces cerevisiae S288C	108-113
9363789-5	1997	These results suggest that Tir1p/Srp1p is a major structural cell wall protein in the static-cultured yeast cells and is bound to the cell wall through beta-1,6-glucan.	beta-1,6-glucan	152-167	GPI-anchored mannoprotein	Saccharomyces cerevisiae S288C	27-32
9363789-5	1997	These results suggest that Tir1p/Srp1p is a major structural cell wall protein in the static-cultured yeast cells and is bound to the cell wall through beta-1,6-glucan.	beta-1,6-glucan	152-167	karyopherin alpha	Saccharomyces cerevisiae S288C	33-38
9363442-4	1997	In the present work, it is shown that Cwh41p, a yeast endoplasmic reticulum protein previously identified as being required for normal cell wall beta-1,6-glucan synthesis (Jiang, Sheraton, Ram, Dijkgraaf, Klis, and Bussey (1996) J.	beta-1,6-glucan	145-160	mannosyl-oligosaccharide glucosidase	Saccharomyces cerevisiae S288C	38-44
9079924-2	1997	We have isolated the C. albicans cDNAs for KRE6 and SKN1, the genes required for beta-1,6-glucan synthesis in Saccharomyces cerevisiae.	beta-1,6-glucan	81-96	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	43-47
9079924-2	1997	We have isolated the C. albicans cDNAs for KRE6 and SKN1, the genes required for beta-1,6-glucan synthesis in Saccharomyces cerevisiae.	beta-1,6-glucan	81-96	beta-glucan synthesis-associated protein SKN1	Saccharomyces cerevisiae S288C	52-56
9079924-7	1997	Although we never succeeded in generating the homozygous C. albicans kre6 delta null mutant, the hemizygous kre6 delta mutation decreased the KRE6 mRNA level by about 60% and also caused a more than 80% reduction of beta-1,6-glucan without affecting beta-1,3-glucan.	beta-1,6-glucan	216-231	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	108-112
9079924-10	1997	These results demonstrate that KRE6 plays important roles in beta-1,6-glucan synthesis and budding in C. albicans.	beta-1,6-glucan	61-76	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	31-35
9090049-4	1997	Cells carrying PBS2 at multiple copy show a small decrease in cell wall beta(1-6) glucans.	beta-1,6-glucan	72-89	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	15-19
9090049-9	1997	Cells carrying the amino portion of MHP1 at multiple copy show a decrease in high molecular weight cell wall beta(1-6) glucans and were killer toxin resistant while a disruption strain was viable and killer toxin super-sensitive.	beta-1,6-glucan	109-126	Mhp1p	Saccharomyces cerevisiae S288C	36-40
8980634-6	1996	Western analysis of a fusion protein consisting of Cwp2p and the reporter enzyme alpha-galactosidase revealed that this protein is glycosyl phosphatidylinositol-anchored in the intracellular precursor form and is recognized by an anti beta-1,6-glucan antiserum in the cell wall bound form.	beta-1,6-glucan	235-250	Cwp2p	Saccharomyces cerevisiae S288C	51-56
8980634-7	1996	The cell wall bound forms of fusion proteins consisting of the anchor regions of Sed1p or Flo1p and alpha-galactosidase were also recognized by an anti beta-1,6-glucan antiserum.	beta-1,6-glucan	152-167	Sed1p	Saccharomyces cerevisiae S288C	81-86
8980634-7	1996	The cell wall bound forms of fusion proteins consisting of the anchor regions of Sed1p or Flo1p and alpha-galactosidase were also recognized by an anti beta-1,6-glucan antiserum.	beta-1,6-glucan	152-167	flocculin FLO1	Saccharomyces cerevisiae S288C	90-95
8810042-2	1996	The product encoded by the KNH1 gene, Knhlp, shares 46% overall identity with Kre9p, a protein required for cell surface beta 1,6-glucan synthesis.	beta-1,6-glucan	121-136	Knh1p	Saccharomyces cerevisiae S288C	27-31
8810042-2	1996	The product encoded by the KNH1 gene, Knhlp, shares 46% overall identity with Kre9p, a protein required for cell surface beta 1,6-glucan synthesis.	beta-1,6-glucan	121-136	Kre9p	Saccharomyces cerevisiae S288C	78-83
8810042-3	1996	While disruption of the KNH1 locus had no effect on cell growth, killer toxin sensitivity or beta 1,6-glucan levels, overexpression of KNH1 was found to suppress the severe growth defect of a kre9 delta mutant and restored the level of alkali-insoluble beta 1,6-glucan to almost wild-type levels.	beta-1,6-glucan	253-268	Knh1p	Saccharomyces cerevisiae S288C	135-139
8724141-4	1996	The beta-1,6-glucan moiety could be removed from Cwp1p and other cell wall proteins by cleaving phosphodiester bridges either enzymatically using phosphodiesterases or chemically using ice-cold aqueous hydrofluoric acid.	beta-1,6-glucan	4-19	Cwp1p	Saccharomyces cerevisiae S288C	49-54
8576053-0	1996	CWH41 encodes a novel endoplasmic reticulum membrane N-glycoprotein involved in beta 1,6-glucan assembly.	beta-1,6-glucan	80-95	mannosyl-oligosaccharide glucosidase	Homo sapiens	0-5
8576053-2	1996	Disruption of the CWH41 gene leads to a K1 killer toxin-resistant phenotype and a 50% reduction in the cell wall beta 1,6-glucan level.	beta-1,6-glucan	113-128	mannosyl-oligosaccharide glucosidase	Homo sapiens	18-23
8576053-3	1996	CWH41 also displays strong genetic interactions with KRE1 and KRE6, two genes known to be involved in the beta 1,6-glucan biosynthetic pathway.	beta-1,6-glucan	106-121	mannosyl-oligosaccharide glucosidase	Homo sapiens	0-5
8576053-4	1996	The cwh41 delta kre6 delta double mutant is nonviable; and the cwh41 delta kre1 delta double mutation results in strong synergistic defects, with a severely slow-growth phenotype, a 75% reduction in beta 1,6-glucan level, and the secretion of a cell wall glucomannoprotein, Cwp1p.	beta-1,6-glucan	199-214	mannosyl-oligosaccharide glucosidase	Homo sapiens	63-68
8576053-5	1996	These results provide strong genetic evidence indicating that Cwh41p plays a functional role, possibly as a new synthetic component, in the assembly of cell wall beta 1,6-glucan.	beta-1,6-glucan	162-177	mannosyl-oligosaccharide glucosidase	Homo sapiens	62-68
7565587-5	1995	Overexpression of EXG1 on a 2 mu plasmid led to reduction in a cell wall beta 1,6-glucan and caused killer resistance in wild type cells; while the exg1 delta mutant displayed modest increases in killer sensitivity and beta 1,6-glucan levels.	beta-1,6-glucan	73-88	glucan 1,3-beta-glucosidase	Saccharomyces cerevisiae S288C	18-22
7565587-5	1995	Overexpression of EXG1 on a 2 mu plasmid led to reduction in a cell wall beta 1,6-glucan and caused killer resistance in wild type cells; while the exg1 delta mutant displayed modest increases in killer sensitivity and beta 1,6-glucan levels.	beta-1,6-glucan	219-234	glucan 1,3-beta-glucosidase	Saccharomyces cerevisiae S288C	18-22
7565587-6	1995	Disruption of PTC1/CWH47 and overexpression of PBS2 gave rise to similar beta-glucan related phenotypes, with higher levels of EXG1 transcription, increased exo-beta-glucanase activity, reduced beta 1,6-glucan levels, and resistance to killer toxin.	beta-1,6-glucan	194-209	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	47-51
8026578-8	1994	88 11295-11299], cells lacking functional KRE6 had a reduced level of the cell wall beta-1,6-glucan compared to that in cells harboring the normal KRE6.	beta-1,6-glucan	84-99	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	42-46
3053174-3	1988	The presence of surface beta-(1----6)glucan (but not beta(1----3)glucan) was observed only after extensive alpha-mannosidase and alkaline phosphatase treatments of blastoconidia.	beta-1,6-glucan	24-43	alpha-mannosidase	Saccharomyces cerevisiae S288C	107-124
33392480-7	2021	This analysis also provided further insights into the functions of actin filaments and the transglutaminase-like protein Cyk3 in cytokinesis and, in addition, defined Kre6 as the likely enzyme that catalyzes beta-1,6-glucan synthesis to drive cell wall maturation during cell growth and division.	beta-1,6-glucan	208-223	Cyk3p	Saccharomyces cerevisiae S288C	121-125
31761915-1	2019	Fluorescence intensities of water-soluble beta-(1,3-1,6)-d-glucan (beta-1,3-glucan)-complexed porphyrin derivatives were very weak as a result of self-quenching.	beta-1,6-glucan	42-65	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	67-75
30507002-0	2019	Blocking beta-1,6-glucan synthesis by deleting KRE6 and SKN1 attenuates the virulence of Candida albicans.	beta-1,6-glucan	9-24	skin antigen 1	Mus musculus	56-60
28732129-9	2017	Given that the big1  mutation caused a failure to attach a GPI-anchored reporter, Cwp2-GFP, to the spore wall, beta-1,6-glucan is involved in tethering of GPI-anchored proteins in the spore wall as well as in the vegetative cell wall.	beta-1,6-glucan	111-126	Big1p	Saccharomyces cerevisiae S288C	15-19
28732129-9	2017	Given that the big1  mutation caused a failure to attach a GPI-anchored reporter, Cwp2-GFP, to the spore wall, beta-1,6-glucan is involved in tethering of GPI-anchored proteins in the spore wall as well as in the vegetative cell wall.	beta-1,6-glucan	111-126	Cwp2p	Saccharomyces cerevisiae S288C	82-86
25165136-8	2014	This suggests that the presumed transglycosidases Dfg5 and Dcw1 of cdc1-314(ts) transfer GPI proteins to cell wall beta1,6-glucans inefficiently.	beta-1,6-glucan	115-130	putative lipid phosphatase CDC1	Saccharomyces cerevisiae S288C	67-71
23296468-7	2013	beta-(1,6)-glucan binding depended on both the stereotypic Ig heavy and light chains, as well as on a distinct amino acid in the IGHV-CDR3.	beta-1,6-glucan	0-17	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	129-133
23296468-8	2013	Reversion of IGHV mutations to germline configuration reduced the affinity for beta-(1,6)-glucan, indicating that these BCRs are indeed affinity-selected for their cognate antigen.	beta-1,6-glucan	79-96	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	13-17
22492205-1	2012	Rot1 is an essential yeast protein originally shown to be implicated in such diverse processes such as beta-1,6-glucan synthesis, actin cytoskeleton dynamics or lysis of autophagic bodies.	beta-1,6-glucan	103-118	Rot1p	Saccharomyces cerevisiae S288C	0-4
22447934-0	2012	Action of multiple endoplasmic reticulum chaperon-like proteins is required for proper folding and polarized localization of Kre6 protein essential in yeast cell wall beta-1,6-glucan synthesis.	beta-1,6-glucan	167-182	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	125-129
22447934-1	2012	Saccharomyces cerevisiae Kre6 is a type II membrane protein essential for cell wall beta-1,6-glucan synthesis.	beta-1,6-glucan	84-99	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	25-29
22447934-5	2012	All mutants of the calnexin cycle member homologues (cwh41, rot2, kre5, and cne1) showed defects in beta-1,6-glucan synthesis, although the calnexin chaperon system is considered not functional in yeast.	beta-1,6-glucan	100-115	mannosyl-oligosaccharide glucosidase	Saccharomyces cerevisiae S288C	53-58
22447934-5	2012	All mutants of the calnexin cycle member homologues (cwh41, rot2, kre5, and cne1) showed defects in beta-1,6-glucan synthesis, although the calnexin chaperon system is considered not functional in yeast.	beta-1,6-glucan	100-115	glucan 1,3-alpha-glucosidase ROT2	Saccharomyces cerevisiae S288C	60-64
22447934-5	2012	All mutants of the calnexin cycle member homologues (cwh41, rot2, kre5, and cne1) showed defects in beta-1,6-glucan synthesis, although the calnexin chaperon system is considered not functional in yeast.	beta-1,6-glucan	100-115	calnexin	Saccharomyces cerevisiae S288C	76-80
22447934-9	2012	In conclusion, the action of multiple ER chaperon-like proteins is required for proper folding and localization of Kre6 and probably Skn1 to function in beta-1,6-glucan synthesis.	beta-1,6-glucan	153-168	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	115-119
22447934-9	2012	In conclusion, the action of multiple ER chaperon-like proteins is required for proper folding and localization of Kre6 and probably Skn1 to function in beta-1,6-glucan synthesis.	beta-1,6-glucan	153-168	beta-glucan synthesis-associated protein SKN1	Saccharomyces cerevisiae S288C	133-137
21193403-0	2011	Kre6 protein essential for yeast cell wall beta-1,6-glucan synthesis accumulates at sites of polarized growth.	beta-1,6-glucan	43-58	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	0-4
21193403-1	2011	Saccharomyces cerevisiae Kre6 is a type II membrane protein with amino acid sequence homology with glycoside hydrolase and is essential for beta-1,6-glucan synthesis as revealed by the mutant phenotype, but its biochemical function is still unknown.	beta-1,6-glucan	140-155	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	25-29
21193403-6	2011	The truncated Kre6 without the N-terminal 230-amino acid cytoplasmic region did not show this polarized accumulation and had a severe defect in beta-1,6-glucan synthesis.	beta-1,6-glucan	144-159	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	14-18
20852022-4	2010	Characterization of the biochemical activity of the proteins indicated that Exg1 and Exg3 are active only against beta(1,6)-glucans while no activity was detected for Exg2.	beta-1,6-glucan	114-131	glucan 1,3-beta-glucosidase	Saccharomyces cerevisiae S288C	76-80
20945493-1	2010	Dectin-1, a specific pattern recognition receptor for beta-1,3/beta-1,6-glucans, is expressed mainly on phagocytes.	beta-1,6-glucan	63-79	C-type lectin domain containing 7A	Homo sapiens	0-8
20945493-1	2010	Dectin-1, a specific pattern recognition receptor for beta-1,3/beta-1,6-glucans, is expressed mainly on phagocytes.	beta-1,6-glucan	63-79	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	54-62
19734368-1	2009	Previous work, using solubilization of yeast cell walls by carboxymethylation, before or after digestion with beta(1-3)- or beta(1-6)glucanase, followed by size chromatography, showed that the transglycosylases Crh1p and Crh2p/Utr2p were redundantly required for the attachment of chitin to beta(1-6)glucan.	beta-1,6-glucan	124-139	transglycosylase	Saccharomyces cerevisiae S288C	211-216
19220866-3	2009	The Rim101p-dependent alterations of the yeast transcriptome following exposure to propionic acid stress (at pH 4.0) include genes of the previously described Rim101p regulon but also new target genes, in particular KNH1, involved in cell wall beta-1,6-glucan synthesis and the uncharacterized ORF YIL029c, both required for maximal propionic acid resistance.	beta-1,6-glucan	244-259	alkaline-responsive transcriptional regulator RIM101	Saccharomyces cerevisiae S288C	4-11
17893149-0	2007	KEG1/YFR042w encodes a novel Kre6-binding endoplasmic reticulum membrane protein responsible for beta-1,6-glucan synthesis in Saccharomyces cerevisiae.	beta-1,6-glucan	97-112	Keg1p	Saccharomyces cerevisiae S288C	0-4
17893149-0	2007	KEG1/YFR042w encodes a novel Kre6-binding endoplasmic reticulum membrane protein responsible for beta-1,6-glucan synthesis in Saccharomyces cerevisiae.	beta-1,6-glucan	97-112	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	29-33
17893149-3	2007	Immunoprecipitation from the Triton X-100-solubilized cell lysate revealed that Keg1 binds to Kre6, which has been known to participate in beta-1,6-glucan synthesis.	beta-1,6-glucan	139-154	Keg1p	Saccharomyces cerevisiae S288C	80-84
17893149-3	2007	Immunoprecipitation from the Triton X-100-solubilized cell lysate revealed that Keg1 binds to Kre6, which has been known to participate in beta-1,6-glucan synthesis.	beta-1,6-glucan	139-154	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	94-98
17893149-5	2007	The keg1-1 mutant cells showed a common phenotype with Deltakre6 mutant including hypersensitivity to Calcofluor white, reduced sensitivity to the K1 killer toxin, and reduced content of beta-1,6-glucan in the cell wall.	beta-1,6-glucan	187-202	Keg1p	Saccharomyces cerevisiae S288C	4-8
17893149-6	2007	These results suggest that Keg1 and Kre6 have a cooperative role in beta-1,6-glucan synthesis in S. cerevisiae.	beta-1,6-glucan	68-83	Keg1p	Saccharomyces cerevisiae S288C	27-31
17893149-6	2007	These results suggest that Keg1 and Kre6 have a cooperative role in beta-1,6-glucan synthesis in S. cerevisiae.	beta-1,6-glucan	68-83	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	36-40
17397129-6	2007	In addition, the ROT1 gene, encoding protein involved in beta1,6-glucan synthesis (Machi et al., 2004) and protein folding (Takeuchi et al., 2006) acted as a multicopy suppressor of the temperature-sensitive phenotype of the sec59-1 mutant.	beta-1,6-glucan	57-71	Rot1p	Saccharomyces cerevisiae S288C	17-21
17397129-6	2007	In addition, the ROT1 gene, encoding protein involved in beta1,6-glucan synthesis (Machi et al., 2004) and protein folding (Takeuchi et al., 2006) acted as a multicopy suppressor of the temperature-sensitive phenotype of the sec59-1 mutant.	beta-1,6-glucan	57-71	dolichol kinase	Saccharomyces cerevisiae S288C	225-230
17368399-1	2007	The deletion of MCD4 leads to an increase in beta-1,6-glucan level and a decrease in glycosylphosphatidylinositol-anchored protein and mannan levels in the cell wall of Saccharomyces cerevisiae, suggesting that mcd4 deletion mutant (mcd4Delta) displays beta-glucans on the cell surface without a mannan cover.	beta-1,6-glucan	45-60	mannose-ethanolamine phosphotransferase MCD4	Saccharomyces cerevisiae S288C	16-20
17302808-0	2007	Crh1p and Crh2p are required for the cross-linking of chitin to beta(1-6)glucan in the Saccharomyces cerevisiae cell wall.	beta-1,6-glucan	64-79	transglycosylase	Saccharomyces cerevisiae S288C	0-5
17302808-0	2007	Crh1p and Crh2p are required for the cross-linking of chitin to beta(1-6)glucan in the Saccharomyces cerevisiae cell wall.	beta-1,6-glucan	64-79	Utr2p	Saccharomyces cerevisiae S288C	10-15
17302808-2	2007	By using a recently developed strategy for the study of cell wall cross-links, we have found that chitin linked to beta(1-6)glucan is diminished in mutants of the CRH1 or the CRH2/UTR2 gene and completely absent in a double mutant.	beta-1,6-glucan	115-130	transglycosylase	Saccharomyces cerevisiae S288C	163-167
17302808-2	2007	By using a recently developed strategy for the study of cell wall cross-links, we have found that chitin linked to beta(1-6)glucan is diminished in mutants of the CRH1 or the CRH2/UTR2 gene and completely absent in a double mutant.	beta-1,6-glucan	115-130	Utr2p	Saccharomyces cerevisiae S288C	175-179
17302808-2	2007	By using a recently developed strategy for the study of cell wall cross-links, we have found that chitin linked to beta(1-6)glucan is diminished in mutants of the CRH1 or the CRH2/UTR2 gene and completely absent in a double mutant.	beta-1,6-glucan	115-130	Utr2p	Saccharomyces cerevisiae S288C	180-184
16552067-2	2006	We analyzed the C. albicans BIG1 homolog, which might be involved in beta-1,6-glucan biosynthesis in Saccharomyces cerevisiae.	beta-1,6-glucan	69-84	Big1p	Saccharomyces cerevisiae S288C	28-32
16233801-0	2005	Deletion of MCD 4 involved in glycosylphosphatidylinositol (GPI) anchor synthesis leads to an increase in beta-1,6-glucan level and a decrease in GPI-anchored protein and mannan levels in the cell wall of Saccharomyces cerevisiae.	beta-1,6-glucan	106-121	mannose-ethanolamine phosphotransferase MCD4	Saccharomyces cerevisiae S288C	12-17
15792805-3	2005	SKN1 was previously shown to be a KRE6 homologue, which is involved in beta-1,6-glucan biosynthesis.	beta-1,6-glucan	71-86	beta-glucan synthesis-associated protein SKN1	Saccharomyces cerevisiae S288C	0-4
15792805-3	2005	SKN1 was previously shown to be a KRE6 homologue, which is involved in beta-1,6-glucan biosynthesis.	beta-1,6-glucan	71-86	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	34-38
15590817-4	2004	S. cerevisiae KRE5 deletion strains show severely reduced levels of cell wall beta-1,6-glucan polymer, aberrant morphology, and extremely compromised growth or lethality, depending on the strain background.	beta-1,6-glucan	78-93	Kre5p	Saccharomyces cerevisiae S288C	14-18
15590817-6	2004	C. albicans kre5/kre5 mutants have significantly reduced levels of beta-1,6-glucan and more chitin and beta-1,3-glucan and less mannoprotein than the WT.	beta-1,6-glucan	67-82	Kre5p	Saccharomyces cerevisiae S288C	12-16
15590817-6	2004	C. albicans kre5/kre5 mutants have significantly reduced levels of beta-1,6-glucan and more chitin and beta-1,3-glucan and less mannoprotein than the WT.	beta-1,6-glucan	67-82	Kre5p	Saccharomyces cerevisiae S288C	17-21
15590817-8	2004	C. albicans KRE5 is a functional homologue of S. cerevisiae KRE5; it partially complements both the growth defect and reduced cell wall beta-1,6-glucan content of S. cerevisiae kre5 viable mutants.	beta-1,6-glucan	136-151	Kre5p	Saccharomyces cerevisiae S288C	12-16
15590817-8	2004	C. albicans KRE5 is a functional homologue of S. cerevisiae KRE5; it partially complements both the growth defect and reduced cell wall beta-1,6-glucan content of S. cerevisiae kre5 viable mutants.	beta-1,6-glucan	136-151	Kre5p	Saccharomyces cerevisiae S288C	60-64
15590817-8	2004	C. albicans KRE5 is a functional homologue of S. cerevisiae KRE5; it partially complements both the growth defect and reduced cell wall beta-1,6-glucan content of S. cerevisiae kre5 viable mutants.	beta-1,6-glucan	136-151	Kre5p	Saccharomyces cerevisiae S288C	177-181
15093776-1	2004	KRE6 (YPR159W) encodes a Golgi membrane protein required for normal beta-1,6-glucan levels in the cell wall.	beta-1,6-glucan	68-83	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	0-4
14676317-6	2003	This proposal was supported by the observation that several stt3 mutants exhibited a 60-70% reduction in the content of cell wall beta1,6-glucan as compared with WT cells.	beta-1,6-glucan	130-144	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3	Saccharomyces cerevisiae S288C	60-64
12909191-8	2003	CNP-induced apoptosis could be blocked by HS 142-1 (a mixture of 20-30 kinds of linear beta-1, 6-glucan esterified by capronic acid, an antagonist of type A and B natriuretic peptide receptors), and KT 5823 (C29H25N3O5), the inhibitor of cGMP-dependent protein kinase).	beta-1,6-glucan	87-103	natriuretic peptide C	Rattus norvegicus	0-3