PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21356152-1	2011	The eicosanoids 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), which are generated from the metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes, possess a wide array of biological actions, including the regulation of blood flow to organs.	epoxyeicosatrienoic acids	62-87	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	159-174
21356152-1	2011	The eicosanoids 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), which are generated from the metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes, possess a wide array of biological actions, including the regulation of blood flow to organs.	epoxyeicosatrienoic acids	62-87	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	176-179
21164107-8	2011	Furthermore, 15d-PGJ(2) and sEH antagonists also increased coronary effluent epoxyeicosatrienoic acids consistent with their vasodilatory actions.	epoxyeicosatrienoic acids	77-102	epoxide hydrolase 2, cytoplasmic	Mus musculus	28-31
21039415-1	2011	BACKGROUND AND PURPOSE: Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase metabolites of arachidonic acid that are metabolized into dihydroxyepoxyeicosatrienoic acids (DHET) by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	24-49	epoxide hydrolase 2	Rattus norvegicus	192-217
21039415-1	2011	BACKGROUND AND PURPOSE: Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase metabolites of arachidonic acid that are metabolized into dihydroxyepoxyeicosatrienoic acids (DHET) by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	24-49	epoxide hydrolase 2	Rattus norvegicus	219-222
20869469-1	2011	Cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA), such as epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid, serve as second messengers of various hormones and growth factors and play pivotal roles in the regulation of vascular, renal and cardiac function.	epoxyeicosatrienoic acids	78-103	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
21040800-0	2011	Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes.	epoxyeicosatrienoic acids	23-48	insulin	Homo sapiens	59-66
21040800-0	2011	Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes.	epoxyeicosatrienoic acids	23-48	insulin	Homo sapiens	90-97
21059750-1	2011	Cytochrome P-450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess potent anti-inflammatory effects in vitro.	epoxyeicosatrienoic acids	31-56	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-16
21059750-1	2011	Cytochrome P-450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess potent anti-inflammatory effects in vitro.	epoxyeicosatrienoic acids	31-56	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	18-21
21030485-1	2011	Cytochrome P450 2J2 (CYP2J2) epoxygenase converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs) that exert multiple biological effects in the cardiovascular system and in various human solid cancers.	epoxyeicosatrienoic acids	89-114	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-19
21030485-1	2011	Cytochrome P450 2J2 (CYP2J2) epoxygenase converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs) that exert multiple biological effects in the cardiovascular system and in various human solid cancers.	epoxyeicosatrienoic acids	89-114	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	21-27
21566342-7	2011	Previously, we showed that CYP3A4 can produce epoxyeicosatrienoic acids (EETs) from arachidonic acid.	epoxyeicosatrienoic acids	46-71	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	27-33
20869469-1	2011	Cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA), such as epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid, serve as second messengers of various hormones and growth factors and play pivotal roles in the regulation of vascular, renal and cardiac function.	epoxyeicosatrienoic acids	78-103	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
21098312-1	2011	Cytochrome P450-derived epoxyeicosatrienoic acids are potent vasodilators in preclinical models and are hydrolyzed by soluble epoxide hydrolase (EPHX2).	epoxyeicosatrienoic acids	24-49	epoxide hydrolase 2	Homo sapiens	145-150
20460345-1	2010	OBJECTIVES: Cytochrome P450 (CYP) 2C19 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which are potent endogenous vasodilators and inhibitors of vascular inflammation.	epoxyeicosatrienoic acids	132-157	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	12-38
20732876-4	2010	CYP2C/2J isoforms converting AA to epoxyeicosatrienoic acids (EETs) preferentially epoxidized the omega-3 double bond and thereby produced 17,18-epoxyeicosatetraenoic (17,18-EEQ) and 19,20-epoxydocosapentaenoic acid (19,20-EDP) from EPA and DHA.	epoxyeicosatrienoic acids	35-60	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	0-7
20495177-1	2010	Renal cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) regulate sodium transport and blood pressure.	epoxyeicosatrienoic acids	36-61	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	6-21
20495177-1	2010	Renal cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) regulate sodium transport and blood pressure.	epoxyeicosatrienoic acids	36-61	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	23-26
20888937-3	2010	Pharmacological inhibition of sEH increases the level of epoxyeicosatrienoic acids, which may have a cardiovascular protective effect.	epoxyeicosatrienoic acids	57-82	epoxide hydrolase 2	Homo sapiens	30-33
20493836-1	2010	Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) catalyzed by cytochrome P450 (CYP), have many essential biologic roles in the cardiovascular system including inhibition of apoptosis in cardiomyocytes.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	84-99
20429668-1	2010	IMPORTANCE OF THE FIELD: Soluble epoxide hydrolase (sEH) inhibitors have been shown to effectively increase the levels of epoxyeicosatrienoic acids and reduce the levels of dihydroxyeicosatrienoic acids, which may be translated to therapeutic potentials for multiple disease indications.	epoxyeicosatrienoic acids	122-147	epoxide hydrolase 2	Homo sapiens	25-50
21416942-2	2010	Epoxyeicosatrienoic acids (EETs), as metabolites of arachidonic acid, are degraded by sEH.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	86-89
20733953-3	2010	Soluble epoxide hydrolase (sEH) is an enzyme that converts endogenous anti-inflammatory compounds, the epoxyeicosatrienoic acids (EETs), to the less anti-inflammatory dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	103-128	epoxide hydrolase 2	Homo sapiens	0-25
20733953-3	2010	Soluble epoxide hydrolase (sEH) is an enzyme that converts endogenous anti-inflammatory compounds, the epoxyeicosatrienoic acids (EETs), to the less anti-inflammatory dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	103-128	epoxide hydrolase 2	Homo sapiens	27-30
20493836-1	2010	Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) catalyzed by cytochrome P450 (CYP), have many essential biologic roles in the cardiovascular system including inhibition of apoptosis in cardiomyocytes.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	101-104
20429668-1	2010	IMPORTANCE OF THE FIELD: Soluble epoxide hydrolase (sEH) inhibitors have been shown to effectively increase the levels of epoxyeicosatrienoic acids and reduce the levels of dihydroxyeicosatrienoic acids, which may be translated to therapeutic potentials for multiple disease indications.	epoxyeicosatrienoic acids	122-147	epoxide hydrolase 2	Homo sapiens	52-55
19969453-1	2010	Inhibition of sEH is hypothesized to lead to an increase in epoxyeicosatrienoic acids resulting in the potentiation of their anti-inflammatory and vasodilatory effects.	epoxyeicosatrienoic acids	60-85	epoxide hydrolase 2	Rattus norvegicus	14-17
19896470-3	2010	Inhibition of sEH stabilizes the cytochrome P450 (CYP450) products epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	67-92	epoxide hydrolase 2, cytoplasmic	Mus musculus	14-17
19940786-1	2010	OBJECTIVE: The contribution of epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) as cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip (2K1C) Goldblatt hypertensive rats was investigated during the phases of initial and stable hypertension, that is, 7 or 27 days after clipping, respectively.	epoxyeicosatrienoic acids	31-56	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	113-129
20093140-4	2010	CYP epoxygenases such as CYP1A2, CYP2C, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which generally possess vasodilating, anti-inflammatory, anti-apoptotic, anti-thrombotic, natriuretic, and cardioprotective effects.	epoxyeicosatrienoic acids	82-107	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	25-31
20093140-4	2010	CYP epoxygenases such as CYP1A2, CYP2C, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which generally possess vasodilating, anti-inflammatory, anti-apoptotic, anti-thrombotic, natriuretic, and cardioprotective effects.	epoxyeicosatrienoic acids	82-107	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	33-38
20093140-4	2010	CYP epoxygenases such as CYP1A2, CYP2C, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which generally possess vasodilating, anti-inflammatory, anti-apoptotic, anti-thrombotic, natriuretic, and cardioprotective effects.	epoxyeicosatrienoic acids	82-107	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	44-50
20045729-1	2010	Cytochrome P450 (CYP) generated cardioprotective metabolites, epoxyeicosatrienoic acids (EETs), and cardiotoxic metabolites, hydroxyeicosatetraenoic acids (HETEs) levels are determined by many factors, including the induction or repression of the CYP enzymes, responsible for their formation.	epoxyeicosatrienoic acids	62-87	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
20045729-1	2010	Cytochrome P450 (CYP) generated cardioprotective metabolites, epoxyeicosatrienoic acids (EETs), and cardiotoxic metabolites, hydroxyeicosatetraenoic acids (HETEs) levels are determined by many factors, including the induction or repression of the CYP enzymes, responsible for their formation.	epoxyeicosatrienoic acids	62-87	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	17-20
20224870-1	2010	Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced by the vascular endothelium in response to agonists such as bradykinin and acetylcholine or physical stimuli such as shear stress or cyclic stretch.	epoxyeicosatrienoic acids	0-25	kininogen 1	Homo sapiens	163-173
20178979-2	2010	The epoxygenase products, the epoxyeicosatrienoic acids, are pro-angiogenic, and down-regulation of their biosynthesis by peroxisomal proliferator-activated receptor alpha (PPARalpha) ligands reduces tumor angiogenesis and growth.	epoxyeicosatrienoic acids	30-55	peroxisome proliferator activated receptor alpha	Homo sapiens	173-182
20050826-1	2010	Recent studies have shown that the renal CYP450 (cytochrome P450) metabolites of AA (arachidonic acid), the vasoconstrictor 20-HETE (20-hydroxyeicosatetraenoic acid) and the vasodilator EETs (epoxyeicosatrienoic acids), play an important role in the pathophysiology of AngII (angiotensin II)-dependent forms of hypertension and the associated target organ damage.	epoxyeicosatrienoic acids	192-217	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	41-47
20050826-1	2010	Recent studies have shown that the renal CYP450 (cytochrome P450) metabolites of AA (arachidonic acid), the vasoconstrictor 20-HETE (20-hydroxyeicosatetraenoic acid) and the vasodilator EETs (epoxyeicosatrienoic acids), play an important role in the pathophysiology of AngII (angiotensin II)-dependent forms of hypertension and the associated target organ damage.	epoxyeicosatrienoic acids	192-217	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	49-64
20050826-1	2010	Recent studies have shown that the renal CYP450 (cytochrome P450) metabolites of AA (arachidonic acid), the vasoconstrictor 20-HETE (20-hydroxyeicosatetraenoic acid) and the vasodilator EETs (epoxyeicosatrienoic acids), play an important role in the pathophysiology of AngII (angiotensin II)-dependent forms of hypertension and the associated target organ damage.	epoxyeicosatrienoic acids	192-217	angiotensinogen	Rattus norvegicus	269-274
20050826-1	2010	Recent studies have shown that the renal CYP450 (cytochrome P450) metabolites of AA (arachidonic acid), the vasoconstrictor 20-HETE (20-hydroxyeicosatetraenoic acid) and the vasodilator EETs (epoxyeicosatrienoic acids), play an important role in the pathophysiology of AngII (angiotensin II)-dependent forms of hypertension and the associated target organ damage.	epoxyeicosatrienoic acids	192-217	angiotensinogen	Rattus norvegicus	276-290
20008276-1	2010	Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs), primarily 14,15-EET.	epoxyeicosatrienoic acids	44-69	epoxide hydrolase 2	Homo sapiens	0-25
20008276-1	2010	Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs), primarily 14,15-EET.	epoxyeicosatrienoic acids	44-69	epoxide hydrolase 2	Homo sapiens	27-30
19891972-1	2010	The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	110-135	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-19
19891972-1	2010	The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	110-135	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-24
19891972-1	2010	The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	110-135	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	56-61
19891972-1	2010	The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	110-135	epoxide hydrolase 2	Homo sapiens	217-242
19891972-1	2010	The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	110-135	epoxide hydrolase 2	Homo sapiens	244-247
21081214-1	2010	Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced by the vascular endothelium in responses to various stimuli such as the agonists acetylcholine (ACH) or bradykinin or by shear stress which activates phospholipase A(2) to release arachidonic acid.	epoxyeicosatrienoic acids	0-25	kininogen 1	Homo sapiens	207-217
19716829-3	2009	sEH catalizes the conversion of epoxyeicosatrienoic acids (EETs) to form the corresponding dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	32-57	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
19847158-2	2010	Epoxyeicosatrienoic acids are generated by soluble epoxide hydrolase, an enzyme hydrolyzing the epoxide moiety of juvenile hormones in insects, and are endothelium-derived hyperpolarizing factors that induce vessel dilation for cardioprotection.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	43-68
19847158-3	2010	Pharmacological inhibition and genetic ablation of soluble epoxide hydrolase increases the level of epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	100-125	epoxide hydrolase 2	Rattus norvegicus	51-76
19847158-5	2010	Treatment with soluble epoxide hydrolase-selective inhibitors in angiotensin II-infused hypertensive rats increases the level of epoxyeicosatrienoic acids, with attendant decrease in systolic blood pressure.	epoxyeicosatrienoic acids	129-154	epoxide hydrolase 2	Rattus norvegicus	15-40
19847158-5	2010	Treatment with soluble epoxide hydrolase-selective inhibitors in angiotensin II-infused hypertensive rats increases the level of epoxyeicosatrienoic acids, with attendant decrease in systolic blood pressure.	epoxyeicosatrienoic acids	129-154	angiotensinogen	Rattus norvegicus	65-79
19782755-1	2010	Soluble epoxide hydrolase (sEH) is a key enzyme involved in the metabolism of epoxy fatty acid mediators such as epoxyeicosatrienoic acids with emerging roles in the regulations of hypertension and inflammation.	epoxyeicosatrienoic acids	113-138	epoxide hydrolase 2	Homo sapiens	0-25
19782755-1	2010	Soluble epoxide hydrolase (sEH) is a key enzyme involved in the metabolism of epoxy fatty acid mediators such as epoxyeicosatrienoic acids with emerging roles in the regulations of hypertension and inflammation.	epoxyeicosatrienoic acids	113-138	epoxide hydrolase 2	Homo sapiens	27-30
19889059-10	2009	Both 3-MC and BaP treatments increased the dihydroxyeicosatrienoic acids (DHETs) : epoxyeicosatrienoic acids (EETs) ratio and the 20-hydroxyeicosatetraenoic acid (20-HETE) : total EETs ratio.	epoxyeicosatrienoic acids	83-108	prohibitin 2	Rattus norvegicus	14-17
19679679-1	2010	AIMS: The C-terminal domain of the soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity.	epoxyeicosatrienoic acids	79-104	epoxide hydrolase 2, cytoplasmic	Mus musculus	35-60
19679679-1	2010	AIMS: The C-terminal domain of the soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity.	epoxyeicosatrienoic acids	79-104	epoxide hydrolase 2, cytoplasmic	Mus musculus	62-65
19935798-2	2009	cytochrome P450 (CYP)2C8/9 metabolise arachidonic acid to epoxyeicosatrienoic acids, which enhance migration and invasion in vitro and promote angiogenesis in vivo.	epoxyeicosatrienoic acids	58-83	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	0-24
19944311-2	2009	Cytochrome P-450 (CYP) 2J2 that is expressed in endothelial cells metabolizes arachidonic acids to biologically active epoxyeicosatrienoic acids (EETs) that possess anti-inflammatory and anti-thrombotic effects.	epoxyeicosatrienoic acids	119-144	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-26
19746975-1	2009	Inhibition of soluble epoxide hydrolase (sEH) is hypothesized to lead to an increase in circulating levels of epoxyeicosatrienoic acids, resulting in the potentiation of their in vivo pharmacological properties.	epoxyeicosatrienoic acids	110-135	epoxide hydrolase 2	Rattus norvegicus	14-39
19746975-1	2009	Inhibition of soluble epoxide hydrolase (sEH) is hypothesized to lead to an increase in circulating levels of epoxyeicosatrienoic acids, resulting in the potentiation of their in vivo pharmacological properties.	epoxyeicosatrienoic acids	110-135	epoxide hydrolase 2	Rattus norvegicus	41-44
19458064-2	2009	sEH converts epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), and the phosphatase activity is suggested to be involved in cholesterol metabolism.	epoxyeicosatrienoic acids	13-38	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
19643090-1	2009	Soluble epoxide hydrolase (sEH) is the major enzyme responsible for the metabolism and inactivation of epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	103-128	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
19643090-1	2009	Soluble epoxide hydrolase (sEH) is the major enzyme responsible for the metabolism and inactivation of epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	103-128	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
19594405-4	2009	Arachidonic acid is metabolized via the epoxidation and omega-hydroxylation to many biologically active eicosanoids such as epoxyeicosatrienoic acids and hydroxyeicosatetraenoic acids by multiple P450 isoforms including CYP2C, CYP2E1 and CYP4A11.	epoxyeicosatrienoic acids	124-149	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	227-233
19594405-4	2009	Arachidonic acid is metabolized via the epoxidation and omega-hydroxylation to many biologically active eicosanoids such as epoxyeicosatrienoic acids and hydroxyeicosatetraenoic acids by multiple P450 isoforms including CYP2C, CYP2E1 and CYP4A11.	epoxyeicosatrienoic acids	124-149	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	238-245
19285984-1	2009	Epoxyeicosatrienoic acids (EETs) are polyunsaturated fatty acids synthesized from arachidonic acid by CYP2J2 epoxygenase and inactivated by soluble epoxide hydrolase (sEH or Ephx2) to dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	102-108
19505190-1	2009	BACKGROUND: CYP enzymes from the CYP2C and CYP2J subfamilies metabolize arachidonic acid in a regiospecific and stereoselective manner to eight epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	144-169	peptidylprolyl isomerase G	Homo sapiens	12-15
19471280-1	2009	Soluble epoxide hydrolase (sEH), a key enzyme in the metabolism of vasodilator eicosanoids called epoxyeicosatrienoic acids (EETs), is sexually dimorphic and suppressed by estrogen.	epoxyeicosatrienoic acids	98-123	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
19471280-1	2009	Soluble epoxide hydrolase (sEH), a key enzyme in the metabolism of vasodilator eicosanoids called epoxyeicosatrienoic acids (EETs), is sexually dimorphic and suppressed by estrogen.	epoxyeicosatrienoic acids	98-123	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
19285984-1	2009	Epoxyeicosatrienoic acids (EETs) are polyunsaturated fatty acids synthesized from arachidonic acid by CYP2J2 epoxygenase and inactivated by soluble epoxide hydrolase (sEH or Ephx2) to dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	167-170
19285984-1	2009	Epoxyeicosatrienoic acids (EETs) are polyunsaturated fatty acids synthesized from arachidonic acid by CYP2J2 epoxygenase and inactivated by soluble epoxide hydrolase (sEH or Ephx2) to dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	174-179
19289568-1	2009	The cytochrome P450 epoxygenase, CYP2J2, converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	89-114	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	33-39
19333883-3	2009	Cardioprotective effects were also achieved when metabolism of the endogenous epoxyeicosatrienoic acids (EETs) by their major enzymatic hydrolysis pathway was blocked in gene knockout mice (EPHX2-/-) or by inhibitors of soluble epoxide hydrolase (sEH), such as 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA).	epoxyeicosatrienoic acids	78-103	epoxide hydrolase 2, cytoplasmic	Mus musculus	190-195
19304946-1	2009	Epoxyeicosatrienoic acids (EETs) are potent vasodilators produced from arachidonic acid by cytochrome P-450 (CYP) epoxygenases and metabolized to vicinal diols by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	163-188
19304946-1	2009	Epoxyeicosatrienoic acids (EETs) are potent vasodilators produced from arachidonic acid by cytochrome P-450 (CYP) epoxygenases and metabolized to vicinal diols by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	190-193
19333883-3	2009	Cardioprotective effects were also achieved when metabolism of the endogenous epoxyeicosatrienoic acids (EETs) by their major enzymatic hydrolysis pathway was blocked in gene knockout mice (EPHX2-/-) or by inhibitors of soluble epoxide hydrolase (sEH), such as 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA).	epoxyeicosatrienoic acids	78-103	epoxide hydrolase 2, cytoplasmic	Mus musculus	220-245
19333883-3	2009	Cardioprotective effects were also achieved when metabolism of the endogenous epoxyeicosatrienoic acids (EETs) by their major enzymatic hydrolysis pathway was blocked in gene knockout mice (EPHX2-/-) or by inhibitors of soluble epoxide hydrolase (sEH), such as 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA).	epoxyeicosatrienoic acids	78-103	epoxide hydrolase 2, cytoplasmic	Mus musculus	247-250
19779591-1	2009	Soluble epoxide hydrolase (sEH) is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	119-144	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
19779591-1	2009	Soluble epoxide hydrolase (sEH) is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	119-144	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
19126686-2	2009	Epoxyeicosatrienoic acids, hydrolyzed and degraded by soluble epoxide hydrolase (sEH), can function as endothelium-derived hyperpolarizing factors to induce dilation of coronary arteries and thus are cardioprotective.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	54-79
19126686-2	2009	Epoxyeicosatrienoic acids, hydrolyzed and degraded by soluble epoxide hydrolase (sEH), can function as endothelium-derived hyperpolarizing factors to induce dilation of coronary arteries and thus are cardioprotective.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	81-84
18787075-0	2008	Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis.	epoxyeicosatrienoic acids	0-25	vascular endothelial growth factor A	Homo sapiens	42-46
18725458-1	2008	Recent findings have indicated a role for cytochrome P-450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) in acute hypoxic pulmonary vasoconstriction (HPV).	epoxyeicosatrienoic acids	85-110	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	42-58
18725458-1	2008	Recent findings have indicated a role for cytochrome P-450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) in acute hypoxic pulmonary vasoconstriction (HPV).	epoxyeicosatrienoic acids	85-110	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	60-63
19000441-1	2008	BACKGROUND & OBJECTIVE: Epoxyeicosatrienoic acids (EETs) are generated from arachidomic acid by cytochrome P450(CYP).	epoxyeicosatrienoic acids	28-53	peptidylprolyl isomerase G	Homo sapiens	116-119
19226702-1	2009	OBJECTIVES: The soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to their less active dihydroxy derivatives.	epoxyeicosatrienoic acids	60-85	epoxide hydrolase 2	Rattus norvegicus	16-41
19226702-1	2009	OBJECTIVES: The soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to their less active dihydroxy derivatives.	epoxyeicosatrienoic acids	60-85	epoxide hydrolase 2	Rattus norvegicus	43-46
18973759-1	2009	Cytochrome P450 epoxygenases metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs) which are in turn converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	65-90	epoxide hydrolase 2, cytoplasmic	Mus musculus	170-195
18973759-1	2009	Cytochrome P450 epoxygenases metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs) which are in turn converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	65-90	epoxide hydrolase 2, cytoplasmic	Mus musculus	197-200
18215190-4	2008	The TRPV4 channels in arterial myocytes are activated by epoxyeicosatrienoic acids, and activation of the channels enhances Ca2+ spark and transient Ca2+-sensitive K+ channel activity, thereby hyperpolarizing and relaxing vascular smooth muscle cells.	epoxyeicosatrienoic acids	57-82	transient receptor potential cation channel subfamily V member 4	Homo sapiens	4-9
18835921-1	2008	Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	44-69	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
18835921-1	2008	Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	44-69	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
18554159-3	2008	While one urchin enzyme did not exhibit EH activity, the second enzyme hydrolyzed several lipid messenger molecules metabolized by the mammalian sEH, including the epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	164-189	epoxide hydrolase 2	Homo sapiens	145-148
18776712-1	2008	Epoxyeicosatrienoic acids (EETs), including 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET, are produced by cytochrome P450 (P450) such as CYP2C8 and 2C9; and they are hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by epoxide hydrolase.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	135-141
18769365-2	2008	Cytochrome P450 2C8 (CYP2C8) and CYP2J2 are polymorphic enzymes expressed in the kidney that metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids, promoting kidney homeostasis.	epoxyeicosatrienoic acids	129-154	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	0-19
18769365-2	2008	Cytochrome P450 2C8 (CYP2C8) and CYP2J2 are polymorphic enzymes expressed in the kidney that metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids, promoting kidney homeostasis.	epoxyeicosatrienoic acids	129-154	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	21-27
18769365-2	2008	Cytochrome P450 2C8 (CYP2C8) and CYP2J2 are polymorphic enzymes expressed in the kidney that metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids, promoting kidney homeostasis.	epoxyeicosatrienoic acids	129-154	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	33-39
18769365-12	2008	CONCLUSION: Inheritance of CYP2C8*3 is associated with a higher risk of developing renal toxicity in patients treated chronically with CNIs, and especially Tac, possibly by reducing formation of kidney protecting vasodilatory epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	226-251	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	27-33
18340006-1	2008	OBJECTIVE: Cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) are known to stimulate angiogenesis, but the mechanisms involved are incompletely understood.	epoxyeicosatrienoic acids	53-78	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	11-26
18340006-1	2008	OBJECTIVE: Cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) are known to stimulate angiogenesis, but the mechanisms involved are incompletely understood.	epoxyeicosatrienoic acids	53-78	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	28-31
17868191-1	2008	The arachidonic acid metabolizing CYP enzymes with prominent roles in vascular regulation are epoxygenases of the two gene family which generate epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	145-170	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	34-37
18496133-2	2008	CYP2J2, CYP2C8, and CYP2C9 are known to be a source of epoxyeicosatrienoic acids in cardiac tissues.	epoxyeicosatrienoic acids	55-80	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
18496133-2	2008	CYP2J2, CYP2C8, and CYP2C9 are known to be a source of epoxyeicosatrienoic acids in cardiac tissues.	epoxyeicosatrienoic acids	55-80	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	8-14
18496133-2	2008	CYP2J2, CYP2C8, and CYP2C9 are known to be a source of epoxyeicosatrienoic acids in cardiac tissues.	epoxyeicosatrienoic acids	55-80	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	20-26
18192241-0	2008	Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	108-133	sphingosine kinase 1	Homo sapiens	14-34
18378855-1	2008	The aim of the present cross-sectional study was to investigate whether activation of the renin-angiotensin system in renovascular disease affects the cytochrome P450 omega/omega-1 hydroxylase (20-hydroxyeicosatetraenoic acid [20-HETE]) and epoxygenase (epoxyeicosatrienoic acids [EETs]) pathways of arachidonic acid metabolism in vivo, each of which interacts with angiotensin II.	epoxyeicosatrienoic acids	254-279	renin	Homo sapiens	90-95
18443590-4	2008	Specifically, we found that cis variation at Ephx2 segregated with heart failure and with increased transcript expression, protein expression and enzyme activity, leading to a more rapid hydrolysis of cardioprotective epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	218-243	epoxide hydrolase 2	Rattus norvegicus	45-50
18181170-2	2008	Cytochrome P450 (CYP) epoxygenase-2J2 (CYP2J2) is abundant in the heart endothelium, and its AA metabolites epoxyeicosatrienoic acids (EETs) mitigates inflammation through NF-kappabeta.	epoxyeicosatrienoic acids	108-133	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	172-184
18055514-0	2008	Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia.	epoxyeicosatrienoic acids	81-106	AKT serine/threonine kinase 1	Rattus norvegicus	43-46
17126841-1	2007	OBJECTIVES: Cytochrome P450 (CYP) 2J2 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which are potent endogenous vasodilators and inhibitors of vascular inflammation.	epoxyeicosatrienoic acids	131-156	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	12-37
18216721-2	2008	This study investigated whether two common polymorphisms in genes believed to be influential in regulating circulating levels of epoxyeicosatrienoic acids, namely cytochrome P450 2J2 (CYP2J2) G-50T and soluble epoxide hydrolase (EPHX2) G860A, were associated with ischemic stroke risk in a Chinese population.	epoxyeicosatrienoic acids	129-154	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	163-182
18216721-2	2008	This study investigated whether two common polymorphisms in genes believed to be influential in regulating circulating levels of epoxyeicosatrienoic acids, namely cytochrome P450 2J2 (CYP2J2) G-50T and soluble epoxide hydrolase (EPHX2) G860A, were associated with ischemic stroke risk in a Chinese population.	epoxyeicosatrienoic acids	129-154	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	184-190
18216721-2	2008	This study investigated whether two common polymorphisms in genes believed to be influential in regulating circulating levels of epoxyeicosatrienoic acids, namely cytochrome P450 2J2 (CYP2J2) G-50T and soluble epoxide hydrolase (EPHX2) G860A, were associated with ischemic stroke risk in a Chinese population.	epoxyeicosatrienoic acids	129-154	epoxide hydrolase 2	Homo sapiens	229-234
17728042-1	2008	The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 arachidonic acid epoxygenases and metabolized through multiple pathways, including soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	21-46	epoxide hydrolase 2, cytoplasmic	Mus musculus	169-194
17728042-1	2008	The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 arachidonic acid epoxygenases and metabolized through multiple pathways, including soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	21-46	epoxide hydrolase 2, cytoplasmic	Mus musculus	196-199
18086949-1	2008	Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids and represents a novel therapeutic target in cardiovascular disease treatment.	epoxyeicosatrienoic acids	44-69	epoxide hydrolase 2	Rattus norvegicus	0-25
18086949-1	2008	Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids and represents a novel therapeutic target in cardiovascular disease treatment.	epoxyeicosatrienoic acids	44-69	epoxide hydrolase 2	Rattus norvegicus	27-30
18276983-2	2008	The Cytochrome P450 (CYP)-derived eicosanoids, 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) have been implicated in the regulation of blood pressure via their vasoactive properties as vasoconstrictors and vasodilators, respectively, as well as via inhibition and activation of endothelial nitric oxide synthase.	epoxyeicosatrienoic acids	93-118	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	4-19
18276983-2	2008	The Cytochrome P450 (CYP)-derived eicosanoids, 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) have been implicated in the regulation of blood pressure via their vasoactive properties as vasoconstrictors and vasodilators, respectively, as well as via inhibition and activation of endothelial nitric oxide synthase.	epoxyeicosatrienoic acids	93-118	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	21-24
17872452-2	2007	Here we address the mechanisms by which cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) contribute to this effect in native and cultured endothelial cells.	epoxyeicosatrienoic acids	70-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-55
17872452-2	2007	Here we address the mechanisms by which cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) contribute to this effect in native and cultured endothelial cells.	epoxyeicosatrienoic acids	70-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	57-60
17638876-1	2007	Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EET), which exert diverse biological activities in a variety of systems.	epoxyeicosatrienoic acids	82-107	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
17652182-1	2007	CYP2J2 is abundant in cardiac tissue and active in the biosynthesis of eicosanoids such as epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	91-116	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
17979511-1	2007	The cytochrome (CYP) P450 epoxygenase pathway catalyzes the epoxidation of arachidonic acids to epoxyeicosatrienoic acids, which are subsequently hydrolyzed to less active dihydroxyeicosatrienoic acids by soluble epoxide hydrolase.	epoxyeicosatrienoic acids	96-121	peptidylprolyl isomerase G	Homo sapiens	16-19
17979511-2	2007	Numerous preclinical studies have demonstrated that CYP-derived epoxyeicosatrienoic acids possess potent vasodilatory and anti-inflammatory properties in the cardiovascular system.	epoxyeicosatrienoic acids	64-89	peptidylprolyl isomerase G	Homo sapiens	52-55
17764757-1	2007	Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) are lipid signalling molecules that elicit vasodilatation and modulate various intracellular signalling cascades.	epoxyeicosatrienoic acids	30-55	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
17764757-1	2007	Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) are lipid signalling molecules that elicit vasodilatation and modulate various intracellular signalling cascades.	epoxyeicosatrienoic acids	30-55	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
17638876-1	2007	Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EET), which exert diverse biological activities in a variety of systems.	epoxyeicosatrienoic acids	82-107	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
17220242-1	2007	The cytochrome P450 (P450) enzymes CYP2C8, CYP2C9, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids, which are known to be vital in regulation of vascular tone and cardiovascular homeostasis.	epoxyeicosatrienoic acids	93-118	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	35-41
17639071-1	2007	The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are endogenous lipid mediators produced in the brain by P450 epoxygenases and metabolized through multiple pathways, including soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	21-46	epoxide hydrolase 2	Rattus norvegicus	181-206
17639071-1	2007	The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are endogenous lipid mediators produced in the brain by P450 epoxygenases and metabolized through multiple pathways, including soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	21-46	epoxide hydrolase 2	Rattus norvegicus	208-211
17429317-1	2007	OBJECTIVE: The cytochromes P450 epoxygenases CYP2J2 and CYP2C8 synthesize epoxyeicosatrienoic acids, which regulate endothelial function.	epoxyeicosatrienoic acids	74-99	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	45-51
17429317-1	2007	OBJECTIVE: The cytochromes P450 epoxygenases CYP2J2 and CYP2C8 synthesize epoxyeicosatrienoic acids, which regulate endothelial function.	epoxyeicosatrienoic acids	74-99	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	56-62
17341586-1	2007	TRPV4, a Ca(2+)-permeable member of the vanilloid subgroup of the transient receptor potential (TRP) channels, is activated by cell swelling and moderate heat (>27 degrees C) as well as by diverse chemical compounds including synthetic 4 alpha-phorbol esters, the plant extract bisandrographolide A, and endogenous epoxyeicosatrienoic acids (EETs; 5,6-EET and 8,9-EET).	epoxyeicosatrienoic acids	318-343	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
17460077-2	2007	EPHX2 encodes for soluble epoxide hydrolase (sEH), an important enzyme in the metabolic breakdown of arachidonic acid-derived eicosanoids referred to as epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	153-178	epoxide hydrolase 2	Homo sapiens	0-5
17460077-2	2007	EPHX2 encodes for soluble epoxide hydrolase (sEH), an important enzyme in the metabolic breakdown of arachidonic acid-derived eicosanoids referred to as epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	153-178	epoxide hydrolase 2	Homo sapiens	18-43
17460077-2	2007	EPHX2 encodes for soluble epoxide hydrolase (sEH), an important enzyme in the metabolic breakdown of arachidonic acid-derived eicosanoids referred to as epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	153-178	epoxide hydrolase 2	Homo sapiens	45-48
17220242-1	2007	The cytochrome P450 (P450) enzymes CYP2C8, CYP2C9, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids, which are known to be vital in regulation of vascular tone and cardiovascular homeostasis.	epoxyeicosatrienoic acids	93-118	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	43-49
17220242-1	2007	The cytochrome P450 (P450) enzymes CYP2C8, CYP2C9, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids, which are known to be vital in regulation of vascular tone and cardiovascular homeostasis.	epoxyeicosatrienoic acids	93-118	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	55-61
17164129-4	2007	A number of these enzymes, including members of the CYP 4 family, predominantly catalyze conversion of AA to 20-hydroxyeicosatetraenoic acid (20-HETE) while the CYP epoxygenases generate mainly epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	194-219	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	52-55
23045145-3	2007	Early work suggested a role of sEH in detoxifying a wide array of xenobiotic epoxides; however, recent findings clearly implicate the sEH in the regulation of blood pressure, pain, and inflammation through the hydrolysis of endogenous epoxy fatty acids such as epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	261-286	epoxide hydrolase 2	Homo sapiens	134-137
17159084-4	2007	Cytochrome P450 enzymes located in the vasculature can metabolize arachidonic acid to produce epoxyeicosatrienoic acids, known vasodilators.	epoxyeicosatrienoic acids	94-119	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-15
17202322-3	2007	Inflammatory cells are capable of releasing arachidonic acid, which may be further metabolized by cyclooxygenase, lipoxygenase, and cytochrome P450 monooxygenase enzymes to biologically active products, including PGs, leukotrienes, epoxyeicosatrienoic acids, and hydroxyeicosatetraenoic acids.	epoxyeicosatrienoic acids	232-257	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	132-161
21204503-3	2007	Although TRPV4 was originally identified as an osmotically activated channel [1-3], recent evidence demonstrates that the channel can be activated by diverse stimuli including hypoosmotic swelling [1-3], shear stress [4], nonnoxious temperatures [5,6], acidity [7], phorbol esters (both protein kinase C-activating and nonactivating phorbol esters) [4,8,9], and downstream metabolites of arachidonic acid (epoxyeicosatrienoic acids) [10,11].	epoxyeicosatrienoic acids	406-431	transient receptor potential cation channel subfamily V member 4	Homo sapiens	9-14
16545818-1	2007	Soluble epoxide hydrolase (EPHX2) catalyses the degradation of the vasoactive and anti-inflammatory epoxyeicosatrienoic acids and may play a role in the pathophysiology of atherosclerosis.	epoxyeicosatrienoic acids	100-125	epoxide hydrolase 2	Homo sapiens	27-32
17164129-4	2007	A number of these enzymes, including members of the CYP 4 family, predominantly catalyze conversion of AA to 20-hydroxyeicosatetraenoic acid (20-HETE) while the CYP epoxygenases generate mainly epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	194-219	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	161-164
17164133-1	2007	Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases the expression of which is determined by hemodynamic and pharmacological stimuli as well as by hypoxia.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	72-87
17164133-1	2007	Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases the expression of which is determined by hemodynamic and pharmacological stimuli as well as by hypoxia.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-92
16734988-3	2006	C6 cells expressed rat epoxygenase mRNAs, CYP1A1, CYP2B1 and CYP2J3, which converted arachidonic acid to epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	105-130	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	42-48
16904368-0	2006	Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	64-89	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	54-60
16380164-1	2006	Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	72-87
16380164-1	2006	Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-92
17130447-4	2006	We tested the use of soluble epoxide hydrolase (sEH) inhibitors as a means to enhance the biological activities of epoxyeicosatrienoic acids (EETs) to treat cardiac hypertrophy.	epoxyeicosatrienoic acids	115-140	epoxide hydrolase 2, cytoplasmic	Mus musculus	21-46
17130447-4	2006	We tested the use of soluble epoxide hydrolase (sEH) inhibitors as a means to enhance the biological activities of epoxyeicosatrienoic acids (EETs) to treat cardiac hypertrophy.	epoxyeicosatrienoic acids	115-140	epoxide hydrolase 2, cytoplasmic	Mus musculus	48-51
16868033-1	2006	CYP2J2 metabolizes arachidonic acid to 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids (EETs), which play a critical role in the regulation of renal, pulmonary, cardiac, and vascular function.	epoxyeicosatrienoic acids	75-100	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
17130543-4	2006	Deficient LXA4 production is not due to deficient lipoxygenase (LO) activity, but is related to increased soluble epoxide hydrolase (sEH), involved in metabolism of anti-inflammatory epoxyeicosatrienoic acids (EET).	epoxyeicosatrienoic acids	183-208	epoxide hydrolase 2, cytoplasmic	Mus musculus	106-131
17130543-4	2006	Deficient LXA4 production is not due to deficient lipoxygenase (LO) activity, but is related to increased soluble epoxide hydrolase (sEH), involved in metabolism of anti-inflammatory epoxyeicosatrienoic acids (EET).	epoxyeicosatrienoic acids	183-208	epoxide hydrolase 2, cytoplasmic	Mus musculus	133-136
16793897-1	2006	We have reported that epoxyeicosatrienoic acids (EETs), the cytochrome P450 (CYP) epoxygenase metabolites of arachidonic acid (AA), are potent sarcolemmal ATP-sensitive K+ (KATP) channel activators.	epoxyeicosatrienoic acids	22-47	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	60-75
16793897-1	2006	We have reported that epoxyeicosatrienoic acids (EETs), the cytochrome P450 (CYP) epoxygenase metabolites of arachidonic acid (AA), are potent sarcolemmal ATP-sensitive K+ (KATP) channel activators.	epoxyeicosatrienoic acids	22-47	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	77-80
16857962-1	2006	Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (Ephx2, sEH).	epoxyeicosatrienoic acids	60-85	epoxide hydrolase 2, cytoplasmic	Mus musculus	184-189
16857962-1	2006	Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (Ephx2, sEH).	epoxyeicosatrienoic acids	60-85	epoxide hydrolase 2, cytoplasmic	Mus musculus	191-194
16307767-1	2006	Epoxyeicosatrienoic acids produced by mouse CYP2B19 have been implicated in mechanisms regulating epidermal cornification (Ladd, P.A., Du, L., Capdevila, J.H., Mernaugh, R., Keeney, D.S., 2003.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 2, subfamily b, polypeptide 19	Mus musculus	44-51
16734988-3	2006	C6 cells expressed rat epoxygenase mRNAs, CYP1A1, CYP2B1 and CYP2J3, which converted arachidonic acid to epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	105-130	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	50-56
16734988-3	2006	C6 cells expressed rat epoxygenase mRNAs, CYP1A1, CYP2B1 and CYP2J3, which converted arachidonic acid to epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	105-130	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	61-67
16267130-2	2005	In this study, we investigated whether epoxyeicosatrienoic acids (EETs), the catalytic products of cytochrome P450 epoxygenases, are PPARgamma ligands.	epoxyeicosatrienoic acids	39-64	peroxisome proliferator activated receptor gamma	Homo sapiens	133-142
16505204-4	2006	Whereas the epoxygenase inhibitor attenuated hypoxic pulmonary constriction (by 52%), the soluble epoxide hydrolase inhibitor enhanced the response (by 39%), indicating that CYP epoxygenase-derived epoxyeicosatrienoic acids elicit pulmonary vasoconstriction.	epoxyeicosatrienoic acids	198-223	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	174-177
16523628-1	2006	The mammalian soluble epoxide hydrolase (sEH) plays a role in the regulation of blood pressure and vascular homeostasis through its hydrolysis of the endothelial-derived messenger molecules, the epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	195-220	epoxide hydrolase 2	Homo sapiens	14-39
16523628-1	2006	The mammalian soluble epoxide hydrolase (sEH) plays a role in the regulation of blood pressure and vascular homeostasis through its hydrolysis of the endothelial-derived messenger molecules, the epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	195-220	epoxide hydrolase 2	Homo sapiens	41-44
16490839-1	2006	Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by cytochrome P450 (CYP) epoxygenases.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-94
16490839-1	2006	Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by cytochrome P450 (CYP) epoxygenases.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	96-99
18221075-2	2006	Soluble epoxide hydrolase (sEH, formerly referred to as cytosolic epoxide hydrolase), which is widely distributed in mammalian tissues, is the primary enzyme responsible for the conversion of epoxyeicosatrienoic acids (EETs), the bioactive lipid mediators formed from arachidonic acid by cytochrome P450 epoxygenase, to their corresponding diols.	epoxyeicosatrienoic acids	192-217	epoxide hydrolase 2	Homo sapiens	0-25
18221075-2	2006	Soluble epoxide hydrolase (sEH, formerly referred to as cytosolic epoxide hydrolase), which is widely distributed in mammalian tissues, is the primary enzyme responsible for the conversion of epoxyeicosatrienoic acids (EETs), the bioactive lipid mediators formed from arachidonic acid by cytochrome P450 epoxygenase, to their corresponding diols.	epoxyeicosatrienoic acids	192-217	epoxide hydrolase 2	Homo sapiens	27-30
16291720-1	2005	Recent studies suggest that cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) elicit cell proliferation and promote angiogenesis.	epoxyeicosatrienoic acids	70-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	28-43
16291720-1	2005	Recent studies suggest that cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) elicit cell proliferation and promote angiogenesis.	epoxyeicosatrienoic acids	70-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	45-48
15895105-0	2005	Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	130-155	kininogen 1	Homo sapiens	0-10
16008525-1	2005	The human cytochrome P450 2J2 (CYP2J2) generates cytoprotective epoxyeicosatrienoic acids from arachidonic acid.	epoxyeicosatrienoic acids	64-89	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	10-29
16008525-1	2005	The human cytochrome P450 2J2 (CYP2J2) generates cytoprotective epoxyeicosatrienoic acids from arachidonic acid.	epoxyeicosatrienoic acids	64-89	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	31-37
16179585-3	2005	Activation by cell swelling and AA requires cytochrome P450 (CYP) epoxygenase activity to convert AA to epoxyeicosatrienoic acids (EETs) such as 5,6-EET, 8,9-EET, which both act as direct TRPV4 agonists.	epoxyeicosatrienoic acids	104-129	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	44-59
16179585-3	2005	Activation by cell swelling and AA requires cytochrome P450 (CYP) epoxygenase activity to convert AA to epoxyeicosatrienoic acids (EETs) such as 5,6-EET, 8,9-EET, which both act as direct TRPV4 agonists.	epoxyeicosatrienoic acids	104-129	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	61-64
16179585-3	2005	Activation by cell swelling and AA requires cytochrome P450 (CYP) epoxygenase activity to convert AA to epoxyeicosatrienoic acids (EETs) such as 5,6-EET, 8,9-EET, which both act as direct TRPV4 agonists.	epoxyeicosatrienoic acids	104-129	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	188-193
16157792-1	2005	The present study tested the hypothesis that increasing epoxyeicosatrienoic acids by inhibition of soluble epoxide hydrolase (sEH) would lower blood pressure and ameliorate renal damage in salt-sensitive hypertension.	epoxyeicosatrienoic acids	56-81	epoxide hydrolase 2	Rattus norvegicus	99-124
16157792-1	2005	The present study tested the hypothesis that increasing epoxyeicosatrienoic acids by inhibition of soluble epoxide hydrolase (sEH) would lower blood pressure and ameliorate renal damage in salt-sensitive hypertension.	epoxyeicosatrienoic acids	56-81	epoxide hydrolase 2	Rattus norvegicus	126-129
16315601-0	2005	Effects of epoxyeicosatrienoic acids on levels of eNOS phosphorylation and relevant signaling transduction pathways involved.	epoxyeicosatrienoic acids	11-36	nitric oxide synthase 3	Bos taurus	50-54
16315601-3	2005	We have demonstrated that cytochrome P450 (CYP) epoxygenase-dependent metabolites of arachidonic acid, epoxyeicosatrienoic acids (EETs), can robustly up-regulate eNOS expression and its activity, however the relevant signaling pathways responsible for activity regulation are not well known.	epoxyeicosatrienoic acids	103-128	nitric oxide synthase 3	Bos taurus	162-166
15814528-1	2005	Cytochrome P-450 (CYP)-dependent epoxyeicosatrienoic acids (EETs) dilate rat preglomerular microvessels when adenosine(2A) receptors (A(2A)R) are stimulated.	epoxyeicosatrienoic acids	33-58	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
15814528-1	2005	Cytochrome P-450 (CYP)-dependent epoxyeicosatrienoic acids (EETs) dilate rat preglomerular microvessels when adenosine(2A) receptors (A(2A)R) are stimulated.	epoxyeicosatrienoic acids	33-58	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	18-21
15729289-3	2005	Cytochrome P450 2C11 is an arachidonic acid (AA) epoxygenase expressed in astrocytes, which metabolizes AA to epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	110-135	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	11-15
15895105-1	2005	In coronary arteries, bradykinin opens endothelial intermediate- and small-conductance Ca2+-sensitive K+ channels (IK(Ca) and SK(Ca)) and, additionally, releases epoxyeicosatrienoic acids (EETs) from the endothelium.	epoxyeicosatrienoic acids	162-187	kininogen 1	Homo sapiens	22-32
15699457-1	2005	The soluble epoxide hydrolase (sEH) metabolizes vasodilatory epoxyeicosatrienoic acids (EETs) to their di-hydroxy derivatives.	epoxyeicosatrienoic acids	61-86	epoxide hydrolase 2, cytoplasmic	Mus musculus	4-29
15840038-2	2005	Recent studies suggest that an endothelial cytochrome P450 (CYP) epoxygenase (CYP 2C9) can modulate endothelium-dependent vasodilatation in two different ways: (1) by the production of epoxyeicosatrienoic acids (EETs), which elicit hyperpolarization and relaxation; and (2) by the release of oxygen-derived free radicals, which compromise the bioavailability of nitric oxide.	epoxyeicosatrienoic acids	185-210	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	78-85
15930289-4	2005	In addition, forced overexpression of CYP2J2, and CYP BM3F87V or addition of epoxyeicosatrienoic acids (EET) in cultured carcinoma cell lines in vitro markedly accelerated proliferation by analyses of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, cell accounts, and cell cycle analysis, and protected carcinoma cells from apoptosis induced by tumor necrosis factor alpha (TNF-alpha) in cultures.	epoxyeicosatrienoic acids	77-102	tumor necrosis factor	Homo sapiens	359-386
15930289-4	2005	In addition, forced overexpression of CYP2J2, and CYP BM3F87V or addition of epoxyeicosatrienoic acids (EET) in cultured carcinoma cell lines in vitro markedly accelerated proliferation by analyses of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, cell accounts, and cell cycle analysis, and protected carcinoma cells from apoptosis induced by tumor necrosis factor alpha (TNF-alpha) in cultures.	epoxyeicosatrienoic acids	77-102	tumor necrosis factor	Homo sapiens	388-397
15699457-1	2005	The soluble epoxide hydrolase (sEH) metabolizes vasodilatory epoxyeicosatrienoic acids (EETs) to their di-hydroxy derivatives.	epoxyeicosatrienoic acids	61-86	epoxide hydrolase 2, cytoplasmic	Mus musculus	31-34
15652503-0	2005	Biosynthesis of epoxyeicosatrienoic acids varies between polymorphic CYP2C enzymes.	epoxyeicosatrienoic acids	16-41	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	69-74
15680914-0	2005	Evidence that cytochrome P450 CYP2B19 is the major source of epoxyeicosatrienoic acids in mouse skin.	epoxyeicosatrienoic acids	61-86	cytochrome P450, family 2, subfamily b, polypeptide 19	Mus musculus	30-37
15680914-2	2005	We aimed to establish whether CYP2B19 is the source of epidermal epoxyeicosatrienoic acids (EETs), which are implicated in mechanisms regulating epidermal cornification.	epoxyeicosatrienoic acids	65-90	cytochrome P450, family 2, subfamily b, polypeptide 19	Mus musculus	30-37
15652503-1	2005	Arachidonic acid is oxidized by cytochromes P450 2C (CYP2C) to epoxyeicosatrienoic acids (EETs), possessing vasoactive properties, with 11,12-EET as the endothelium derived hyperpolarization factor.	epoxyeicosatrienoic acids	63-88	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	32-51
15652503-1	2005	Arachidonic acid is oxidized by cytochromes P450 2C (CYP2C) to epoxyeicosatrienoic acids (EETs), possessing vasoactive properties, with 11,12-EET as the endothelium derived hyperpolarization factor.	epoxyeicosatrienoic acids	63-88	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	53-58
15329052-3	2004	It has been proposed that ACh elicits a hyperpolarization of the coronary endothelial cells which may be accompanied by the activation of cytochrome P450 (CYP) and the resulting release of epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	189-214	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	155-158
15569819-0	2005	Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells.	epoxyeicosatrienoic acids	27-52	prostaglandin-endoperoxide synthase 2	Homo sapiens	78-94
15383399-1	2005	Epoxyeicosatrienoic acids (EETs), which belong to cytochrome P-450 (CYP)-derived eicosanoids, have been implicated to vasodilate renal arterioles, inhibit sodium transport in the nephron, and regulate blood pressure in several animal models.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	50-66
15383399-1	2005	Epoxyeicosatrienoic acids (EETs), which belong to cytochrome P-450 (CYP)-derived eicosanoids, have been implicated to vasodilate renal arterioles, inhibit sodium transport in the nephron, and regulate blood pressure in several animal models.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	68-71
15637425-1	2005	BACKGROUND: Cytochrome P450 (CYP) isoenzymes (CYP2C and CYP2J) are involved in the production of epoxyeicosatrienoic acids, which are postulated as endothelium-derived hyperpolarizing factors (EDHFs).	epoxyeicosatrienoic acids	97-122	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	46-51
15466638-1	2004	BACKGROUND: Cytochrome P450 (CYP) 2J2 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	135-160	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	12-37
15190971-3	2004	Since CYP2C11 and CYP2J4 convert arachidonic acid to vasodilative epoxyeicosatrienoic acids, and CYP4A3 metabolizes arachidonic acid to both epoxyeicosatrienoic acids and vasoconstrictive 19,20-hydroxyeicosatetraenoic acid, the aim of this study was to examine the expression of these isoforms in sepsis and their association with hemodynamic changes.	epoxyeicosatrienoic acids	66-91	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	6-13
15503650-4	2004	Cytochrome P450 metabolism of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) or epoxyeicosatrienoic acids (EETs) provides a mechanism for the constriction and relaxation of cerebral arteries, respectively.	epoxyeicosatrienoic acids	95-120	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
15353362-4	2004	We have demonstrated that leukotrienes (LTs; 5-LOX-derived eicosanoids) and various isomers of epoxyeicosatrienoic acids (EETs; epoxygenase-derived eicosanoids) contribute to the process of endogenous antipyresis or cryogenesis, which limits the height of fever.	epoxyeicosatrienoic acids	95-120	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	128-139
15190971-3	2004	Since CYP2C11 and CYP2J4 convert arachidonic acid to vasodilative epoxyeicosatrienoic acids, and CYP4A3 metabolizes arachidonic acid to both epoxyeicosatrienoic acids and vasoconstrictive 19,20-hydroxyeicosatetraenoic acid, the aim of this study was to examine the expression of these isoforms in sepsis and their association with hemodynamic changes.	epoxyeicosatrienoic acids	66-91	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	18-24
15190971-3	2004	Since CYP2C11 and CYP2J4 convert arachidonic acid to vasodilative epoxyeicosatrienoic acids, and CYP4A3 metabolizes arachidonic acid to both epoxyeicosatrienoic acids and vasoconstrictive 19,20-hydroxyeicosatetraenoic acid, the aim of this study was to examine the expression of these isoforms in sepsis and their association with hemodynamic changes.	epoxyeicosatrienoic acids	141-166	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	6-13
15190971-3	2004	Since CYP2C11 and CYP2J4 convert arachidonic acid to vasodilative epoxyeicosatrienoic acids, and CYP4A3 metabolizes arachidonic acid to both epoxyeicosatrienoic acids and vasoconstrictive 19,20-hydroxyeicosatetraenoic acid, the aim of this study was to examine the expression of these isoforms in sepsis and their association with hemodynamic changes.	epoxyeicosatrienoic acids	141-166	cytochrome P450, family 4, subfamily a, polypeptide 3	Rattus norvegicus	97-103
15102943-6	2004	CYP2C50 and CYP2C54 metabolize AA to epoxyeicosatrienoic acids (EETs) primarily, and linoleic acid to epoxyoctadecenoic acids (EOAs) primarily, whereas CYP2C55 metabolizes AA to EETs and hydroxyeicosatetraenoic acids and linoleic acid to EOAs and hydroxyoctadecadienoic acids.	epoxyeicosatrienoic acids	37-62	cytochrome P450, family 2, subfamily c, polypeptide 50	Mus musculus	0-7
15102943-6	2004	CYP2C50 and CYP2C54 metabolize AA to epoxyeicosatrienoic acids (EETs) primarily, and linoleic acid to epoxyoctadecenoic acids (EOAs) primarily, whereas CYP2C55 metabolizes AA to EETs and hydroxyeicosatetraenoic acids and linoleic acid to EOAs and hydroxyoctadecadienoic acids.	epoxyeicosatrienoic acids	37-62	cytochrome P450, family 2, subfamily c, polypeptide 54	Mus musculus	12-19
14978252-1	2004	Mouse CYP2J5 is abundant in kidney and active in the metabolism of arachidonic acid to epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	87-112	cytochrome P450, family 2, subfamily j, polypeptide 5	Mus musculus	6-12
15202615-4	2004	RECENT FINDINGS: Studies have demonstrated that the expression of cytochrome P-450 enzymes and the synthesis of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in the kidney and peripheral vasculature are altered in many genetic and experimental models of hypertension.	epoxyeicosatrienoic acids	148-173	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	66-82
12892558-3	2003	In particular, there has been considerable support for a role for the cytochrome P450 metabolites, the epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	103-128	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-85
12865253-1	2003	Nitric oxide (NO) inhibits hemoproteins, including cytochrome (CYP) 2C, the gene responsible for the production of epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	115-140	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	0-70
12975498-1	2003	Cytochrome P450 (P450)-dependent metabolites of arachidonic acid, the epoxyeicosatrienoic acids (EETs), are proposed to be endothelium-derived hyperpolarizing factors (EDHF) that affect vascular tone; however, the effects of EDHF on endothelial-derived nitric oxide biosynthesis remain unknown.	epoxyeicosatrienoic acids	70-95	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-21
14670845-10	2004	Moreover, GC-MS analysis indicated a significantly increased production of epoxyeicosatrienoic acids, vasodilator metabolites of CYP/epoxygenase, in arterioles incubated with 17beta-E2, a response that was prevented by ICI 182780 and wortmannin, respectively.	epoxyeicosatrienoic acids	75-100	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	129-132
14707014-3	2004	TRPV4, which displays 45% sequence identity with TRPV1, is characterized by a surprising gating promiscuity: it is activated by hypotonic cell swelling, heat, synthetic 4alpha-phorbols, and several endogenous substances including arachidonic acid (AA), the endocannabinoids anandamide and 2-AG, and cytochrome P-450 metabolites of AA, such as epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	343-368	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
14707014-3	2004	TRPV4, which displays 45% sequence identity with TRPV1, is characterized by a surprising gating promiscuity: it is activated by hypotonic cell swelling, heat, synthetic 4alpha-phorbols, and several endogenous substances including arachidonic acid (AA), the endocannabinoids anandamide and 2-AG, and cytochrome P-450 metabolites of AA, such as epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	343-368	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-54
14718251-1	2004	Activation of rat adenosine2A receptors (A2A R) dilates preglomerular microvessels (PGMV), an effect mediated by epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	113-138	adenosine A2a receptor	Rattus norvegicus	18-39
14718251-1	2004	Activation of rat adenosine2A receptors (A2A R) dilates preglomerular microvessels (PGMV), an effect mediated by epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	113-138	adenosine A2a receptor	Rattus norvegicus	41-46
12939236-2	2003	Renal cytochrome P450 (CYP)-derived eicosanoids--hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DHETs)--have been shown to play an important role in the regulation of renal function, vascular tone, and blood pressure.	epoxyeicosatrienoic acids	88-113	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	6-21
12939236-2	2003	Renal cytochrome P450 (CYP)-derived eicosanoids--hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DHETs)--have been shown to play an important role in the regulation of renal function, vascular tone, and blood pressure.	epoxyeicosatrienoic acids	88-113	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	23-26
12016269-2	2002	The epoxyeicosatrienoic acids (EETs), which are products of cytochrome P450 (CYP) epoxygenases, possess vasodilatory, antiinflammatory, and fibrinolytic properties.	epoxyeicosatrienoic acids	4-29	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	60-75
14626496-2	2003	CYP-AA metabolites, 19- and 20-hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs) and diHETEs have different biological properties based on sites of production and can be stored in tissue lipids and released in response to hormonal stimuli.	epoxyeicosatrienoic acids	70-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
12870664-2	2003	Cytochrome P450 (CYP), shown to mediate endothelium-dependent hyperpolarization via epoxyeicosatrienoic acids, is one of the candidates for EDHF.	epoxyeicosatrienoic acids	84-109	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
12870664-2	2003	Cytochrome P450 (CYP), shown to mediate endothelium-dependent hyperpolarization via epoxyeicosatrienoic acids, is one of the candidates for EDHF.	epoxyeicosatrienoic acids	84-109	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
12586744-0	2003	Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR).	epoxyeicosatrienoic acids	28-53	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	0-19
12586744-0	2003	Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR).	epoxyeicosatrienoic acids	28-53	epidermal growth factor receptor	Homo sapiens	98-130
12586744-0	2003	Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR).	epoxyeicosatrienoic acids	28-53	epidermal growth factor receptor	Homo sapiens	132-136
12675279-6	2003	Purified CYP3A4 produced epoxyeicosatrienoic acids (EETs) from arachidonic acid, and the production was abolished by a selective CYP3A inhibitor, ketoconazole.	epoxyeicosatrienoic acids	25-50	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	9-15
12879072-0	2003	Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels.	epoxyeicosatrienoic acids	36-61	transient receptor potential cation channel subfamily V member 4	Homo sapiens	74-79
12879072-4	2003	Here we show that the endocannabinoid anandamide and its metabolite arachidonic acid activate TRPV4 in an indirect way involving the cytochrome P450 epoxygenase-dependent formation of epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	184-209	transient receptor potential cation channel subfamily V member 4	Homo sapiens	94-99
12623785-2	2003	We hypothesized that increased production of arachidonic acid metabolites such as the cyclooxygenase product prostacyclin or cytochrome p-450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) contributes to VSM cell hyperpolarization following CH.	epoxyeicosatrienoic acids	168-193	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	125-141
12623785-2	2003	We hypothesized that increased production of arachidonic acid metabolites such as the cyclooxygenase product prostacyclin or cytochrome p-450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) contributes to VSM cell hyperpolarization following CH.	epoxyeicosatrienoic acids	168-193	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	143-146
12016269-2	2002	The epoxyeicosatrienoic acids (EETs), which are products of cytochrome P450 (CYP) epoxygenases, possess vasodilatory, antiinflammatory, and fibrinolytic properties.	epoxyeicosatrienoic acids	4-29	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	77-80
11773611-1	2002	Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and that these compounds play critical roles in the regulation of renal, pulmonary, and cardiac function and vascular tone.	epoxyeicosatrienoic acids	215-240	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	80-96
11964373-2	2002	Here, we assessed the mechanisms by which the epoxyeicosatrienoic acids (EETs) generated by a CYP 2C enzyme control interendothelial gap junctional communication.	epoxyeicosatrienoic acids	46-71	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	94-100
11789779-2	2001	The cytochrome P-450-monooxygenase metabolites of arachidonic acid (epoxyeicosatrienoic acids [EETs]) have been suggested to be EDHF.	epoxyeicosatrienoic acids	68-93	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	4-34
11773611-1	2002	Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and that these compounds play critical roles in the regulation of renal, pulmonary, and cardiac function and vascular tone.	epoxyeicosatrienoic acids	215-240	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	98-101
11679404-5	2001	This review summarizes the vascular effects of epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid, both of which are CYP-derived metabolites of arachidonic acid, endogenously generated within endothelial and vascular smooth muscle cells.	epoxyeicosatrienoic acids	47-72	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	128-131
11811373-3	2001	Among the vasorelaxants are nitric oxide (NO), prostacyclin, various endothelium-derived hyperpolarizing factors (EDHFs, such as cytochrome P-450 monooxygenase metabolites of arachidonic acid like epoxyeicosatrienoic acids, and endocannabinoids), and C-type natriuretic peptide.	epoxyeicosatrienoic acids	197-222	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	129-159
11566953-10	2001	These data suggest that during development of kidney failure, there is induction of the AT(2) receptors, which may account for increased Ang II-dependent vasodilatation through the predominant release of epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	204-229	angiotensinogen	Rattus norvegicus	137-143
11195057-1	2001	Recent studies indicate that arachidonic acid is primarily metabolized by cytochrome P450 enzymes of the 4A and 2C families in the kidney to 20-hydroxyeicosatetraenoic acid (HETE), epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	181-206	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	74-89
11139472-2	2001	As some CYP enzymes are reported to generate reactive oxygen species (ROS), we hypothesized that the coronary EDHF synthase may modulate vascular homeostasis by the simultaneous production of ROS and epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	200-225	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	8-11
11455018-1	2001	CYP2J2 is abundant in human heart and its arachidonic acid metabolites, the epoxyeicosatrienoic acids (EETs), have potent vasodilatory, antiinflammatory and cardioprotective properties.	epoxyeicosatrienoic acids	76-101	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
11279071-0	2001	Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	101-126	plasminogen activator, tissue type	Homo sapiens	45-78
11125019-1	2001	Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites of cytochrome P450 monooxygenase, which are released from endothelial cells and dilate arteries.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	69-98
11001943-1	2000	Renal microsomal cytochrome P-450 monooxygenase-dependent metabolism of arachidonic acid generates a series of regioisomeric epoxyeicosatrienoic acids that can be further metabolized by soluble epoxide hydrolase to the corresponding dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	125-150	cytochrome P450, family 20, subfamily a, polypeptide 1	Mus musculus	17-47
11001943-1	2000	Renal microsomal cytochrome P-450 monooxygenase-dependent metabolism of arachidonic acid generates a series of regioisomeric epoxyeicosatrienoic acids that can be further metabolized by soluble epoxide hydrolase to the corresponding dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	125-150	epoxide hydrolase 2, cytoplasmic	Mus musculus	186-211
11090543-0	2000	Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	61-86	epoxide hydrolase 2	Rattus norvegicus	0-25
9694933-1	1998	Epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids, products of the cytochrome P450 arachidonic acid epoxygenase pathway, have been shown to affect electrolyte transport in the kidney; however, the effects of these compounds on airway epithelial ion transport have not been investigated.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 2, subfamily c, polypeptide 23	Rattus norvegicus	100-128
11071299-2	2000	Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP)-dependent pathways to epoxyeicosatrienoic acids (EET) and 20-hydroxyeicosatetraenoic acid (20-HETE) in the kidney and the peripheral vasculature.	epoxyeicosatrienoic acids	84-109	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	40-55
11071299-2	2000	Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP)-dependent pathways to epoxyeicosatrienoic acids (EET) and 20-hydroxyeicosatetraenoic acid (20-HETE) in the kidney and the peripheral vasculature.	epoxyeicosatrienoic acids	84-109	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	57-60
9927620-1	1999	Epoxyeicosatrienoic acids (EETs), products of the cytochrome P-450 monooxygenase metabolism of arachidonic acid, can regulate the activity of ion channels.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	50-80
9876291-9	1998	The postulated main contenders are epoxyeicosatrienoic acids or endocannabinoid agonists for the CB1-receptors.	epoxyeicosatrienoic acids	35-60	cannabinoid receptor 1	Homo sapiens	97-100
10924087-1	2000	Epoxyeicosatrienoic acids (EETs) are cytochrome P-450 metabolites of arachidonic acid involved in the regulation of vascular tone.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	37-53
10779386-1	2000	Epoxyeicosatrienoic acids (EETs) are major products of cytochrome P450 (CYP)-catalyzed metabolism of arachidonic acid in the kidney.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	55-70
10779386-1	2000	Epoxyeicosatrienoic acids (EETs) are major products of cytochrome P450 (CYP)-catalyzed metabolism of arachidonic acid in the kidney.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	72-75
11239797-2	2000	Not only is there strong evidence suggesting that the putative coronary EDHF synthase is an endothelially expressed CYP epoxygenase, but CYP products such as epoxyeicosatrienoic acids and reactive oxygen species have been implicated in the regulation of intracellular signalling cascades and vascular cell proliferation.	epoxyeicosatrienoic acids	158-183	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	137-140
10364221-14	1999	In light of the well documented effects of epoxyeicosatrienoic acids in modulating renal tubular transport processes, we postulate that CYP2J5 products play important functional roles in the kidney.	epoxyeicosatrienoic acids	43-68	cytochrome P450, family 2, subfamily j, polypeptide 5	Mus musculus	136-142
9430380-1	1997	Arachidonic acid is converted to epoxyeicosatrienoic acids (EETs) by cytochrome P450 monooxygenases.	epoxyeicosatrienoic acids	33-58	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	69-84
9617761-1	1998	Although epoxyeicosatrienoic acids, cytochrome P-450 mono-oxygenase metabolites of arachidonic acid, have been demonstrated to play a crucial role in endothelial cell Ca2+ homeostasis and endothelium-dependent vasorelaxation, the understanding of the actions of epoxyeicosatrienoic acids is limited.	epoxyeicosatrienoic acids	9-34	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	36-67
9617761-1	1998	Although epoxyeicosatrienoic acids, cytochrome P-450 mono-oxygenase metabolites of arachidonic acid, have been demonstrated to play a crucial role in endothelial cell Ca2+ homeostasis and endothelium-dependent vasorelaxation, the understanding of the actions of epoxyeicosatrienoic acids is limited.	epoxyeicosatrienoic acids	262-287	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	36-67
9617761-5	1998	This effect of arachidonic acid was abolished in the presence of the cytochrome P-450 mono-oxygenase inhibitor thiopentone sodium, indicating that arachidonic acids needs to be converted to epoxyeicosatrienoic acids by the endothelial cytochrome P-450 mono-oxygenase to stimulate tyrosine kinase.	epoxyeicosatrienoic acids	190-215	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	69-100
9617761-5	1998	This effect of arachidonic acid was abolished in the presence of the cytochrome P-450 mono-oxygenase inhibitor thiopentone sodium, indicating that arachidonic acids needs to be converted to epoxyeicosatrienoic acids by the endothelial cytochrome P-450 mono-oxygenase to stimulate tyrosine kinase.	epoxyeicosatrienoic acids	190-215	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	235-266
9478043-3	1998	Thereafter, it may be metabolized by at least two cyclooxygenase (COX) isoforms to prostaglandins and related compounds, via lipoxygenases to leukotrienes and via p450-catalyzed metabolism to epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	192-217	cytochrome c oxidase subunit 8A	Homo sapiens	66-69
9242187-1	1997	Epoxyeicosatrienoic acids (EETs) are potent endothelium-derived vasodilators formed from cytochrome P-450 metabolism of arachidonic acid.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-105
8897950-1	1996	Arachidonic acid (AA) is metabolized by the cytochrome P-450 (P-450) epoxygenase pathway to epoxyeicosatrienoic acids (EETs) in the brain parenchymal tissue and perivascular astrocytes.	epoxyeicosatrienoic acids	92-117	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	44-60
9187259-7	1997	Direct evidence for the in vivo epoxidation of arachidonic acid by intestinal cytochrome P450 was provided by documenting, for the first time, the presence of epoxyeicosatrienoic acids in human jejunum by gas chromatography/mass spectrometry.	epoxyeicosatrienoic acids	159-184	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	78-93
9048644-8	1997	These data together with previous work showing effects of epoxyeicosatrienoic acids in stimulating insulin and glucagon secretion from isolated rat pancreatic islets support the hypothesis that epoxygenase products may be involved in stimulus-secretion coupling in the pancreas.	epoxyeicosatrienoic acids	58-83	insulin	Homo sapiens	99-106
8940291-1	1996	As a participant of the endogenous arachidonic acid metabolic cascade, microsomal cytochrome P450 metabolizes the fatty acid to biologically active hydroxyeicosatetraenoic and epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	176-201	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	82-97
8651708-5	1996	Importantly, the chirality of liver epoxyeicosatrienoic acids matched that previously reported for recombinant CYP2C8 (Zeldin et al.	epoxyeicosatrienoic acids	36-61	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	111-117
8687505-8	1996	The precocious expression of CYP2C in SIDS could result in a higher production of epoxyeicosatrienoic acids in the neonate, believed to act as relaxant of pulmonary smooth muscles.	epoxyeicosatrienoic acids	82-107	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	29-34
8651708-12	1996	We conclude, based on these data, that CYP2C8 is one of the primary, constitutive hepatic arachidonic acid epoxygenases responsible for formation of epoxyeicosatrienoic acids and that cytosolic epoxide hydrolase is the principal liver enzyme which forms the dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	149-174	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	39-45
7625847-3	1995	Liver CYP arachidonate products include epoxyeicosatrienoic acids (EETs) and monohydroxylated products (HETEs).	epoxyeicosatrienoic acids	40-65	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	6-9
8631948-8	1996	The in vivo significance of CYP2J2 was suggested by documenting the presence of epoxyeicosatrienoic acids in the human heart using gas chromatography/mass spectroscopy.	epoxyeicosatrienoic acids	80-105	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	28-34
8631948-10	1996	We propose that CYP2J2 is one of the enzymes responsible for epoxidation of endogenous arachidonic acid pools in human heart and that epoxyeicosatrienoic acids may, therefore, play important functional roles in cardiac physiology.	epoxyeicosatrienoic acids	134-159	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	16-22
7840649-0	1995	Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis.	epoxyeicosatrienoic acids	14-39	epoxide hydrolase 2	Rattus norvegicus	43-70
7721444-1	1995	Phospholipase A2 (Naja mocambique) catalyzed release of epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) from phospholipids of isolated human platelets.	epoxyeicosatrienoic acids	56-81	phospholipase A2 group IB	Homo sapiens	0-16
8022420-0	1994	Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	169-194	cytochrome P450IIB	Cavia porcellus	110-129
7952074-1	1994	A chromatographic method was developed to separate enantiomers of four regioisomeric epoxyeicosatrienoic acids (EETs), which are cytochrome P-450 monooxygenase products of arachidonic acid.	epoxyeicosatrienoic acids	85-110	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	129-159
8205390-5	1994	Regioselectivity of arachidonic acid oxygenation was observed in suncus liver microsomes; rat liver microsomal cytochrome P-450 generated epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acid as major products while the cytochrome P-450-dependent monooxygenase in suncus liver microsomes yielded omega- and (omega-1)-hydroxyarachidonic acids as major reaction products.	epoxyeicosatrienoic acids	138-163	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	111-127
33811614-0	2021	Dihydroxyeicosatrienoic Acid, a Metabolite of Epoxyeicosatrienoic Acids Upregulates Endothelial Nitric Oxide Synthase Expression Through Transcription: Mechanism of Vascular Endothelial Function Protection.	epoxyeicosatrienoic acids	46-71	nitric oxide synthase 3, endothelial cell	Mus musculus	84-117
1457335-3	1992	AA is metabolized by the renal cytochrome P-450 epoxygenase and omega/omega 1 hydroxylases to epoxyeicosatrienoic acids and omega/omega-1 alcohols (20- and 19-mono-hydroxyeicosatetraenoic acids), respectively.	epoxyeicosatrienoic acids	94-119	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	31-47
2124686-1	1990	In the presence of NADPH cytochrome P-450-dependent monooxygenases oxidize arachidonic acid giving rise to four epoxyeicosatrienoic acids (EETs) which are hydrolyzed enzymatically to dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	112-137	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	25-41
8246128-6	1993	Arachidonic acid metabolism catalyzed by expressed CYP2C23 indicated that CYP2C23 efficiently produced epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	103-128	cytochrome P450, family 2, subfamily c, polypeptide 23	Rattus norvegicus	51-58
8246128-6	1993	Arachidonic acid metabolism catalyzed by expressed CYP2C23 indicated that CYP2C23 efficiently produced epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	103-128	cytochrome P450, family 2, subfamily c, polypeptide 23	Rattus norvegicus	74-81
1400301-0	1992	Epoxyeicosatrienoic acids inhibit Ca2+ entry into platelets stimulated by thapsigargin and thrombin.	epoxyeicosatrienoic acids	0-25	coagulation factor II, thrombin	Homo sapiens	91-99
1740420-1	1992	The different regioisomers of epoxyeicosatrienoic acids derived from cytochrome P-450 monooxygenase are readily esterified into phospholipids of mastocytoma cells.	epoxyeicosatrienoic acids	30-55	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	69-99
1968382-1	1990	The epoxyeicosatrienoic acids (EETs) were discovered as products of a cyclooxygenase/lipoxygenase-independent, cytochrome P-450 catalyzed metabolism of arachidonic acid (AA) termed the "epoxygenase" pathway.	epoxyeicosatrienoic acids	4-29	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	111-127
33777999-2	2020	The aim of this study was to assess the cardiovascular impact of the pharmacological inhibition of soluble epoxide hydrolase (sEH), which metabolizes the endothelium-derived vasodilatory and anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acid (DHETs), in the 5/6 nephrectomy (Nx) mouse model.	epoxyeicosatrienoic acids	209-234	epoxide hydrolase 2, cytoplasmic	Mus musculus	99-124
33777999-2	2020	The aim of this study was to assess the cardiovascular impact of the pharmacological inhibition of soluble epoxide hydrolase (sEH), which metabolizes the endothelium-derived vasodilatory and anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acid (DHETs), in the 5/6 nephrectomy (Nx) mouse model.	epoxyeicosatrienoic acids	209-234	epoxide hydrolase 2, cytoplasmic	Mus musculus	126-129
33588415-2	2020	sEH metabolizes biologically highly active and generally cytoprotective epoxyeicosatrienoic acids (EETs), generated from arachidonic acid metabolism by CYP epoxygenases (CYP2C and CYP2J subfamilies), to less active corresponding diols.	epoxyeicosatrienoic acids	72-97	epoxide hydrolase 2	Homo sapiens	0-3
34774051-1	2021	BACKGROUND: Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert anti-inflammatory, anti-apoptotic, pro-proliferative, and antioxidant effects on the cardiovascular system.	epoxyeicosatrienoic acids	85-110	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	12-43
34794001-2	2021	The soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatetraenoic acids.	epoxyeicosatrienoic acids	47-72	epoxide hydrolase 2	Rattus norvegicus	31-34
34597782-0	2021	Epoxyeicosatrienoic Acids Prevent Cardiomyocytes against Sepsis by A2AR-induced Activation of PI3K and PPARgamma.	epoxyeicosatrienoic acids	0-25	adenosine A2a receptor	Mus musculus	67-71
34597782-0	2021	Epoxyeicosatrienoic Acids Prevent Cardiomyocytes against Sepsis by A2AR-induced Activation of PI3K and PPARgamma.	epoxyeicosatrienoic acids	0-25	peroxisome proliferator activated receptor gamma	Mus musculus	103-112
34774051-1	2021	BACKGROUND: Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert anti-inflammatory, anti-apoptotic, pro-proliferative, and antioxidant effects on the cardiovascular system.	epoxyeicosatrienoic acids	85-110	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	45-51
34411643-7	2021	Furthermore, inhibition of sEH could ameliorate neuroinflammation, neuronal death, and oxidative stress via stabilizing the in vivo level of epoxyeicosatrienoic acids (EETs), especially 8,9-EET and 14,15-EET, further resulting in the anti-AD effect through the regulation of GSK3beta-mediated NF-kappaB, p53, and Nrf2 signaling pathways.	epoxyeicosatrienoic acids	141-166	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
34672113-2	2022	Epoxyeicosatrienoic acids (EETs) are endogenous anti-inflammatory mediators, rapidly metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	100-125
34672113-2	2022	Epoxyeicosatrienoic acids (EETs) are endogenous anti-inflammatory mediators, rapidly metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	127-130
34592333-2	2021	Soluble epoxide hydrolase (sEH) is the key enzyme in the epoxyeicosatrienoic acids (EETs) signaling.	epoxyeicosatrienoic acids	57-82	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
34592333-2	2021	Soluble epoxide hydrolase (sEH) is the key enzyme in the epoxyeicosatrienoic acids (EETs) signaling.	epoxyeicosatrienoic acids	57-82	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
34411643-7	2021	Furthermore, inhibition of sEH could ameliorate neuroinflammation, neuronal death, and oxidative stress via stabilizing the in vivo level of epoxyeicosatrienoic acids (EETs), especially 8,9-EET and 14,15-EET, further resulting in the anti-AD effect through the regulation of GSK3beta-mediated NF-kappaB, p53, and Nrf2 signaling pathways.	epoxyeicosatrienoic acids	141-166	glycogen synthase kinase 3 alpha	Mus musculus	275-283
34411643-7	2021	Furthermore, inhibition of sEH could ameliorate neuroinflammation, neuronal death, and oxidative stress via stabilizing the in vivo level of epoxyeicosatrienoic acids (EETs), especially 8,9-EET and 14,15-EET, further resulting in the anti-AD effect through the regulation of GSK3beta-mediated NF-kappaB, p53, and Nrf2 signaling pathways.	epoxyeicosatrienoic acids	141-166	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	293-302
34411643-7	2021	Furthermore, inhibition of sEH could ameliorate neuroinflammation, neuronal death, and oxidative stress via stabilizing the in vivo level of epoxyeicosatrienoic acids (EETs), especially 8,9-EET and 14,15-EET, further resulting in the anti-AD effect through the regulation of GSK3beta-mediated NF-kappaB, p53, and Nrf2 signaling pathways.	epoxyeicosatrienoic acids	141-166	transformation related protein 53, pseudogene	Mus musculus	304-307
34411643-7	2021	Furthermore, inhibition of sEH could ameliorate neuroinflammation, neuronal death, and oxidative stress via stabilizing the in vivo level of epoxyeicosatrienoic acids (EETs), especially 8,9-EET and 14,15-EET, further resulting in the anti-AD effect through the regulation of GSK3beta-mediated NF-kappaB, p53, and Nrf2 signaling pathways.	epoxyeicosatrienoic acids	141-166	nuclear factor, erythroid derived 2, like 2	Mus musculus	313-317
34646152-1	2021	Background: Soluble epoxide hydrolase inhibitors (sEHis) inhibit the degradation of epoxyeicosatrienoic acids (EETs) in cells, and EETs have antiarrhythmic effects.	epoxyeicosatrienoic acids	84-109	epoxide hydrolase 2, cytoplasmic	Mus musculus	12-37
34509915-1	2021	Soluble epoxide hydrolase (sEH), an enzyme that broadly regulates the cardiovascular system, hydrolyses epoxyeicosatrienoic acids (EETs) to their corresponding dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	104-129	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
34509915-1	2021	Soluble epoxide hydrolase (sEH), an enzyme that broadly regulates the cardiovascular system, hydrolyses epoxyeicosatrienoic acids (EETs) to their corresponding dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	104-129	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
35354305-13	2022	POR deletion reduced endothelial stores of CYP-derived epoxyeicosatrienoic acids but increased vascular prostanoids.	epoxyeicosatrienoic acids	55-80	cytochrome p450 oxidoreductase	Mus musculus	0-3
34548575-0	2021	Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicit vasoconstriction of the murine ophthalmic artery.	epoxyeicosatrienoic acids	28-53	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	0-7
34142887-2	2021	Epoxyeicosatrienoic acids (EETs), hydrolyzed by soluble epoxide hydrolase (sEH), have beneficial effects against vascular dysfunction.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	48-73
34142887-2	2021	Epoxyeicosatrienoic acids (EETs), hydrolyzed by soluble epoxide hydrolase (sEH), have beneficial effects against vascular dysfunction.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	75-78
34063817-1	2021	Soluble epoxide hydrolase (sEH) is abundant in the brain, is upregulated in type 2 diabetes mellitus (DM2), and is possible mediator of ischemic injury via the breakdown of neuroprotective epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	189-214	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
34063817-1	2021	Soluble epoxide hydrolase (sEH) is abundant in the brain, is upregulated in type 2 diabetes mellitus (DM2), and is possible mediator of ischemic injury via the breakdown of neuroprotective epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	189-214	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
34707002-0	2021	CYP2J2-produced epoxyeicosatrienoic acids contribute to the ferroptosis resistance of pancreatic ductal adenocarcinoma in a PPARgamma-dependent manner.	epoxyeicosatrienoic acids	16-41	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
34707002-0	2021	CYP2J2-produced epoxyeicosatrienoic acids contribute to the ferroptosis resistance of pancreatic ductal adenocarcinoma in a PPARgamma-dependent manner.	epoxyeicosatrienoic acids	16-41	peroxisome proliferator activated receptor gamma	Homo sapiens	124-133
34707002-4	2021	Cytochrome P450 2J2 (CYP2J2) is the main enzyme which mediates arachidonic acid to produce epoxyeicosatrienoic acids (EETs) in human tissues.	epoxyeicosatrienoic acids	91-116	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-19
34707002-4	2021	Cytochrome P450 2J2 (CYP2J2) is the main enzyme which mediates arachidonic acid to produce epoxyeicosatrienoic acids (EETs) in human tissues.	epoxyeicosatrienoic acids	91-116	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	21-27
34405218-0	2021	(Endogenous protective effects of arachidonic acid epoxygenase metabolites, epoxyeicosatrienoic acids, in cardiovascular system).	epoxyeicosatrienoic acids	76-101	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	34-62
35344709-3	2022	Epoxyeicosatrienoic acids (EETs) were reported to have anti-hypertensive effects, which could be degraded by soluble epoxide hydrolase (sEH), encoded by EPHX2.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	109-134
35344709-3	2022	Epoxyeicosatrienoic acids (EETs) were reported to have anti-hypertensive effects, which could be degraded by soluble epoxide hydrolase (sEH), encoded by EPHX2.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	136-139
2556446-1	1989	AA is metabolized by a cytochrome P450, NADPH-dependent epoxygenase to four regioisomeric epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	90-115	cytochrome P-450	Oryctolagus cuniculus	23-38
35344709-3	2022	Epoxyeicosatrienoic acids (EETs) were reported to have anti-hypertensive effects, which could be degraded by soluble epoxide hydrolase (sEH), encoded by EPHX2.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	153-158
35484372-4	2022	We focused on inhibition of soluble epoxide hydrolase to prolong the activation of epoxyeicosatrienoic acids, which have vasodilatory and anti-inflammatory properties.	epoxyeicosatrienoic acids	83-108	epoxide hydrolase 2, cytoplasmic	Mus musculus	28-53
35474783-2	2022	On the other hand, CYP2C8 is not only crucial for alteration in the pharmacokinetics of drugs to cause drug interaction but also unequivocally important for the metabolism of endogenous substances like the formation of epoxyeicosatrienoic acids (EETs), which are considered as signaling molecules against hallmarks of cancer.	epoxyeicosatrienoic acids	219-244	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	19-25
2563927-0	1989	Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs.	epoxyeicosatrienoic acids	10-35	growth hormone 1	Homo sapiens	39-53
2584196-5	1989	These results demonstrate the enzymatic origin of the epoxyeicosatrienoic acids present in rat liver and document a novel metabolic function for cytochrome P-450 in the regio- and enatioselective epoxygenation of endogenous pools of arachidonic acid.	epoxyeicosatrienoic acids	54-79	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	145-161
2563927-1	1989	Growth hormone secretion was stimulated in vitro by products of arachidonic acid epoxygenase, the epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	98-123	growth hormone 1	Homo sapiens	0-14
2563927-1	1989	Growth hormone secretion was stimulated in vitro by products of arachidonic acid epoxygenase, the epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	98-123	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	64-92
2563927-9	1989	These data are suggestive that the epoxyeicosatrienoic acids may have a role in the secretion of growth hormone.	epoxyeicosatrienoic acids	35-60	growth hormone 1	Homo sapiens	97-111
3580381-0	1987	Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine.	epoxyeicosatrienoic acids	43-68	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-28
4051502-1	1985	The catalysis of glutathione (GSH) conjugation to epoxyeicosatrienoic acids (EETs) by various purified isozymes of glutathione S-transferase was studied.	epoxyeicosatrienoic acids	50-75	glutathione S-transferase kappa 1	Homo sapiens	115-140
3105909-0	1987	Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase.	epoxyeicosatrienoic acids	27-52	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	97-126
6411091-2	1983	Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the in vitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	43-65
33387601-0	2021	Epoxyeicosatrienoic acids Improve Glucose Homeostasis by Preventing NF-kappaB-mediated Transcription of SGLT2 in Renal Tubular Epithelial Cells.	epoxyeicosatrienoic acids	0-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	68-77
6859878-1	1983	Epoxyeicosatrienoic acids, formed during the cytochrome P-450-catalyzed oxidation of arachidonic acid, react with a liver cytosolic epoxide hydrolase to form vicinal diols of eicosatrienoic acid.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	45-61
34038767-5	2021	We postulated that hyperglycemia-induced elevation in sEH leads to a reduction in its substrates, epoxyeicosatrienoic acids (EETs), and attenuates the function of beta-cells.	epoxyeicosatrienoic acids	98-123	epoxide hydrolase 2	Homo sapiens	54-57
33976432-6	2021	We demonstrated a moderate positive correlation between the expression of CYP2C8 and sEH in chorioamnionitis (Spearman r = 0.5654), suggesting enhanced degradation of anti-inflammatory epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	185-210	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	74-80
33976432-6	2021	We demonstrated a moderate positive correlation between the expression of CYP2C8 and sEH in chorioamnionitis (Spearman r = 0.5654), suggesting enhanced degradation of anti-inflammatory epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	185-210	epoxide hydrolase 2	Homo sapiens	85-88
33595911-4	2021	Soluble epoxide hydrolase (sEH) is an enzyme that degrades epoxyeicosatrienoic acids (EETs), which have multiple protective effects by suppressing inflammation, apoptosis and oxidative stress.	epoxyeicosatrienoic acids	59-84	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
33595911-4	2021	Soluble epoxide hydrolase (sEH) is an enzyme that degrades epoxyeicosatrienoic acids (EETs), which have multiple protective effects by suppressing inflammation, apoptosis and oxidative stress.	epoxyeicosatrienoic acids	59-84	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
34044117-1	2021	Extrahepatic CYP2J2 metabolism of arachidonic acid (AA) to bioactive regioisomeric epoxyeicosatrienoic acids (EETs) is implicated in both physiological and pathological conditions.	epoxyeicosatrienoic acids	83-108	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	13-19
33990688-1	2021	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that are rapidly metabolized into diols by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	112-137
33990688-1	2021	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that are rapidly metabolized into diols by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	139-142
33994786-1	2020	Purpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury owing to their participation in the regulation of vascular tone and cerebral blood flow.	epoxyeicosatrienoic acids	112-137	epoxide hydrolase 2	Homo sapiens	9-34
33994786-1	2020	Purpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury owing to their participation in the regulation of vascular tone and cerebral blood flow.	epoxyeicosatrienoic acids	112-137	epoxide hydrolase 2	Homo sapiens	36-39
33994786-1	2020	Purpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury owing to their participation in the regulation of vascular tone and cerebral blood flow.	epoxyeicosatrienoic acids	112-137	epoxide hydrolase 1	Homo sapiens	45-73
33994786-1	2020	Purpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury owing to their participation in the regulation of vascular tone and cerebral blood flow.	epoxyeicosatrienoic acids	112-137	epoxide hydrolase 1, microsomal	Mus musculus	75-78
33378686-2	2021	Soluble epoxide hydrolase (sEH) is the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), which have biological activity of regulating lipid metabolism.	epoxyeicosatrienoic acids	69-94	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
33378686-2	2021	Soluble epoxide hydrolase (sEH) is the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), which have biological activity of regulating lipid metabolism.	epoxyeicosatrienoic acids	69-94	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
33387601-0	2021	Epoxyeicosatrienoic acids Improve Glucose Homeostasis by Preventing NF-kappaB-mediated Transcription of SGLT2 in Renal Tubular Epithelial Cells.	epoxyeicosatrienoic acids	0-25	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	104-109
33580125-1	2021	This study addressed the hypothesis that epoxyeicosatrienoic acids (EETs) synthesized by CYP450 and catabolized by soluble epoxide hydrolase (sEH) are involved in the maintenance of renal allograft function, either directly or through modulation of cardiovascular function.	epoxyeicosatrienoic acids	41-66	epoxide hydrolase 2, cytoplasmic	Mus musculus	115-140
33580125-1	2021	This study addressed the hypothesis that epoxyeicosatrienoic acids (EETs) synthesized by CYP450 and catabolized by soluble epoxide hydrolase (sEH) are involved in the maintenance of renal allograft function, either directly or through modulation of cardiovascular function.	epoxyeicosatrienoic acids	41-66	epoxide hydrolase 2, cytoplasmic	Mus musculus	142-145
33279296-2	2021	In addition to the two metabolic pathways regulated by cyclooxygenase and lipoxygenase, AA has a third metabolic pathway through which cytochrome P450 (CYP) enzymes produce hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	215-240	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	135-150
33279296-2	2021	In addition to the two metabolic pathways regulated by cyclooxygenase and lipoxygenase, AA has a third metabolic pathway through which cytochrome P450 (CYP) enzymes produce hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	215-240	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	152-155
32767848-2	2021	Epoxyeicosatrienoic acids (EETs) are vasodilators; their actions are potentiated by soluble epoxide hydrolase (sEH) inhibition.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	84-109
33369424-2	2021	The inhibition of sEH can effectively maintain endogenous epoxyeicosatrienoic acids (EETs) levels and reduce dihydroxyeicosatrienoic acids (DHETs) levels, resulting in therapeutic potentials for cardiovascular, central nervous system, and metabolic diseases.	epoxyeicosatrienoic acids	58-83	epoxide hydrolase 2	Homo sapiens	18-21
32767848-2	2021	Epoxyeicosatrienoic acids (EETs) are vasodilators; their actions are potentiated by soluble epoxide hydrolase (sEH) inhibition.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	111-114
33456570-2	2021	Lack of 12/15LOX dampens proinflammatory mediator 12-(S)-hydroxyeicosatetraenoic acid (12-(S)-HETE), improves post-MI survival, through the biosynthesis of endogenous mediators epoxyeicosatrienoic acids (EETs; cypoxins) to resolve post-MI inflammation.	epoxyeicosatrienoic acids	177-202	arachidonate 15-lipoxygenase	Mus musculus	8-16
33239900-3	2020	Giving the importance of epoxyeicosatrienoic acids (EETs) in kidney health, we aimed to study the association between two SNPs in the genes controlling synthesis and degradation of EETs (CYP2J2 rs2280275 and EPHX2 rs751141 respectively) and susceptibility of type 2 diabetes mellitus (T2DM) patients to develop DN.	epoxyeicosatrienoic acids	25-50	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	187-193
33255197-2	2020	The substrate-specific hydrolase activity of sEH converts epoxyeicosatrienoic acids (EETs) to less bioactive dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	58-83	epoxide hydrolase 2	Homo sapiens	45-48
33239900-3	2020	Giving the importance of epoxyeicosatrienoic acids (EETs) in kidney health, we aimed to study the association between two SNPs in the genes controlling synthesis and degradation of EETs (CYP2J2 rs2280275 and EPHX2 rs751141 respectively) and susceptibility of type 2 diabetes mellitus (T2DM) patients to develop DN.	epoxyeicosatrienoic acids	25-50	epoxide hydrolase 2	Homo sapiens	208-213
32224017-1	2020	INTRODUCTION: Cytochrome P450 (CYP) 2J2 is a major enzyme that controls epoxyeicosatrienoic acids biosynthesis, which may play a role in chronic obstructive pulmonary disease (COPD) development.	epoxyeicosatrienoic acids	72-97	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	14-39
32294527-1	2020	Epoxyeicosatrienoic acids (EETs) are synthetized from arachidonic acid by the action of members of the CYP2C and CYP2J subfamilies of cytochrome P450 (CYPs).	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	103-108
32452554-0	2020	Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages.	epoxyeicosatrienoic acids	0-25	NLR family, pyrin domain containing 3	Mus musculus	52-57
32736189-2	2020	Epoxyeicosatrienoic acids (EETs) are endogenous anti-inflammatory compounds, which are quickly converted by the soluble epoxide hydrolase (sEH) enzyme into a less active form with decreased biological effects.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	112-137
32736189-2	2020	Epoxyeicosatrienoic acids (EETs) are endogenous anti-inflammatory compounds, which are quickly converted by the soluble epoxide hydrolase (sEH) enzyme into a less active form with decreased biological effects.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	139-142
33475089-1	2020	Stabilization of epoxyeicosatrienoic acids (EETs) levels via soluble epoxide hydrolase (sEH) deletion or its pharmacological inhibition have been shown to have beneficial effects on inflammation, ischemia, hypertension and diabetes.	epoxyeicosatrienoic acids	17-42	epoxide hydrolase 2	Rattus norvegicus	61-86
32560362-0	2020	The Metabolism of Epoxyeicosatrienoic Acids by Soluble Epoxide Hydrolase Is Protective against the Development of Vascular Calcification.	epoxyeicosatrienoic acids	18-43	epoxide hydrolase 2	Homo sapiens	47-72
32400048-1	2020	Epoxyeicosatrienoic acids (EET) and related epoxy fatty acids (EpFA) are endogenous anti-inflammatory compounds, which are converted by the soluble epoxide hydrolase (sEH) to dihydroxylethersatrienoic acids (DHETs) with lessened biological effects.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	140-165
32400048-1	2020	Epoxyeicosatrienoic acids (EET) and related epoxy fatty acids (EpFA) are endogenous anti-inflammatory compounds, which are converted by the soluble epoxide hydrolase (sEH) to dihydroxylethersatrienoic acids (DHETs) with lessened biological effects.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	167-170
32560362-1	2020	This study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes endothelium-derived epoxyeicosatrienoic acids, plays a role in vascular calcification.	epoxyeicosatrienoic acids	112-137	epoxide hydrolase 2	Homo sapiens	41-66
32560362-1	2020	This study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes endothelium-derived epoxyeicosatrienoic acids, plays a role in vascular calcification.	epoxyeicosatrienoic acids	112-137	epoxide hydrolase 2	Homo sapiens	68-71
32560362-5	2020	Similarly, exogenous epoxyeicosatrienoic acids potentiated the calcification of rat aortic rings through a protein kinase A (PKA)-dependent mechanism and of human aortic vascular smooth muscle cells when sEH was inhibited by t-AUCB.	epoxyeicosatrienoic acids	21-46	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	107-123
32560362-5	2020	Similarly, exogenous epoxyeicosatrienoic acids potentiated the calcification of rat aortic rings through a protein kinase A (PKA)-dependent mechanism and of human aortic vascular smooth muscle cells when sEH was inhibited by t-AUCB.	epoxyeicosatrienoic acids	21-46	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	125-128
32560362-5	2020	Similarly, exogenous epoxyeicosatrienoic acids potentiated the calcification of rat aortic rings through a protein kinase A (PKA)-dependent mechanism and of human aortic vascular smooth muscle cells when sEH was inhibited by t-AUCB.	epoxyeicosatrienoic acids	21-46	epoxide hydrolase 2	Homo sapiens	204-207
32560362-7	2020	These results show that sEH hydrolase plays a protective role against vascular calcification by reducing the bioavailability of epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	128-153	epoxide hydrolase 2	Homo sapiens	24-27
31318834-3	2020	N-[1-(1-oxopropyl)-4-piperidinyl]-N"-[4-(trifluoromethoxy)phenyl)-urea (TPPU) is an inhibitor of soluble epoxide hydrolase (sEH), which can rapidly hydrolyze epoxyeicosatrienoic acids (EETs) to the bio-inactive dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	158-183	epoxide hydrolase 2, cytoplasmic	Mus musculus	97-122
32114358-1	2020	Arachidonic acid can be metabolized to prostaglandins and epoxyeicosatrienoic acids (EETs) by cyclooxygenase-2 (COX-2) and cytochrome P450 (CYP), respectively.	epoxyeicosatrienoic acids	58-83	prostaglandin-endoperoxide synthase 2	Mus musculus	94-110
32114358-1	2020	Arachidonic acid can be metabolized to prostaglandins and epoxyeicosatrienoic acids (EETs) by cyclooxygenase-2 (COX-2) and cytochrome P450 (CYP), respectively.	epoxyeicosatrienoic acids	58-83	prostaglandin-endoperoxide synthase 2	Mus musculus	112-117
32439839-2	2020	Soluble epoxide hydrolase (sEH) is an enzyme that can hydrolyze epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids (EpFAs) into the less biologically active metabolites.	epoxyeicosatrienoic acids	64-89	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
32439839-2	2020	Soluble epoxide hydrolase (sEH) is an enzyme that can hydrolyze epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids (EpFAs) into the less biologically active metabolites.	epoxyeicosatrienoic acids	64-89	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
31415769-3	2019	Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP) epoxygenase-derived metabolites of arachidonic acid, protecting against diabetes and DN.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	37-52
32308747-7	2020	Decrease mRNA expression of Cyp2j9, Cyp2j6, and Cyp2j5 was observed, which metabolize ARA into epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	95-120	cytochrome P450, family 2, subfamily j, polypeptide 9	Mus musculus	28-34
32308747-7	2020	Decrease mRNA expression of Cyp2j9, Cyp2j6, and Cyp2j5 was observed, which metabolize ARA into epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	95-120	cytochrome P450, family 2, subfamily j, polypeptide 6	Mus musculus	36-42
32308747-7	2020	Decrease mRNA expression of Cyp2j9, Cyp2j6, and Cyp2j5 was observed, which metabolize ARA into epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	95-120	cytochrome P450, family 2, subfamily j, polypeptide 5	Mus musculus	48-54
32210298-1	2020	CYP2J2, a member of the Cytochrome P450 family of enzymes, is the most abundant epoxygenase in the heart and has multifunctional properties including bioactivation of arachidonic acid to epoxyeicosatrienoic acids, which, in turn, have been implicated in mediating several cardiovascular conditions.	epoxyeicosatrienoic acids	187-212	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
32192153-2	2020	EPHX2 metabolizes anti-inflammatory epoxyeicosatrienoic acids into pro-inflammatory diols.	epoxyeicosatrienoic acids	36-61	epoxide hydrolase 2	Homo sapiens	0-5
31295013-3	2019	Expressed in the vascular endothelium, cytochrome P450 (CYP) 2J2 is one of the CYP epoxygenases that metabolize arachidonic acid to produce epoxyeicosatrienoic acids and exert pleiotropic protective effects on the vasculature.	epoxyeicosatrienoic acids	140-165	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	39-64
31150667-0	2020	Nax-positive glial cells in the organum vasculosum laminae terminalis produce epoxyeicosatrienoic acids to induce water intake in response to increases in [Na+] in body fluids.	epoxyeicosatrienoic acids	78-103	sodium channel, voltage-gated, type VII, alpha	Mus musculus	0-3
31150667-3	2020	Our pharmacological experiments suggested that Nax signals led to activation of neurons bearing TRPV4 by using epoxyeicosatrienoic acids (EETs) as gliotransmitters to stimulate water intake.	epoxyeicosatrienoic acids	111-136	sodium channel, voltage-gated, type VII, alpha	Mus musculus	47-50
31150667-3	2020	Our pharmacological experiments suggested that Nax signals led to activation of neurons bearing TRPV4 by using epoxyeicosatrienoic acids (EETs) as gliotransmitters to stimulate water intake.	epoxyeicosatrienoic acids	111-136	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	96-101
32001002-3	2020	Soluble epoxide hydrolase (sEH) is an enzyme that degrades epoxyeicosatrienoic acids (EETs), which have multiple protective effects on vascular structure and functions.	epoxyeicosatrienoic acids	59-84	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
32001002-3	2020	Soluble epoxide hydrolase (sEH) is an enzyme that degrades epoxyeicosatrienoic acids (EETs), which have multiple protective effects on vascular structure and functions.	epoxyeicosatrienoic acids	59-84	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
31902555-1	2020	BACKGROUND: Cytochrome P450 2J2 is mostly expressed in extrahepatic tissues; it metabolizes arachidonic acid to epoxyeicosatrienoic acids, with various cardio protective and anti-inflammatory effects.	epoxyeicosatrienoic acids	112-137	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	12-31
31622444-1	2019	Cytochrome P450 (CYP) enzymes metabolize arachidonic acid to vasoactive eicosanoids such as epoxyeicosatrienoic acids (EETs) and 20-Hydroxyeicosatetraenoic acid (20-HETE), whilst soluble epoxide hydrolase, encoded by the EPHX2 gene, is in charge of EETs degradation.	epoxyeicosatrienoic acids	92-117	epoxide hydrolase 2	Homo sapiens	221-226
31415769-3	2019	Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP) epoxygenase-derived metabolites of arachidonic acid, protecting against diabetes and DN.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	54-57
31271766-1	2019	Cytochrome P450 (CYP) epoxygenases and their metabolic products, epoxyeicosatrienoic acids (EETs), have been proposed as important therapeutic targets in the brain.	epoxyeicosatrienoic acids	65-90	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	17-20
31306370-3	2019	Of interest, cytochrome P450 2J (CYP2J) and soluble epoxide hydrolase (sEH) are known to control the maintenance of cardiovascular health through the regulation of cardioprotective epoxyeicosatrienoic acids (EETs) and its less active products, dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	181-206	epoxide hydrolase 2	Homo sapiens	44-69
31306370-3	2019	Of interest, cytochrome P450 2J (CYP2J) and soluble epoxide hydrolase (sEH) are known to control the maintenance of cardiovascular health through the regulation of cardioprotective epoxyeicosatrienoic acids (EETs) and its less active products, dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	181-206	epoxide hydrolase 2	Homo sapiens	71-74
30610956-2	2019	Meanwhile, Nox4 dependent reactive oxygen species (ROS) signaling and soluble epoxide hydrolase (sEH)/epoxyeicosatrienoic acids (EETs) are both involved in vascular inflammation.	epoxyeicosatrienoic acids	102-127	epoxide hydrolase 2, cytoplasmic	Mus musculus	70-95
30610956-2	2019	Meanwhile, Nox4 dependent reactive oxygen species (ROS) signaling and soluble epoxide hydrolase (sEH)/epoxyeicosatrienoic acids (EETs) are both involved in vascular inflammation.	epoxyeicosatrienoic acids	102-127	epoxide hydrolase 2, cytoplasmic	Mus musculus	97-100
30804206-6	2019	Also, administration of an sEH inhibitor, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea, significantly attenuated the HFD-caused renal injury, decreased renal sEH consistently at mRNA and protein levels, modified the renal levels of sEH-mediated epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids (DHETs) as expected, and increased renal Pax2 and Ampk at mRNA and/or protein levels.	epoxyeicosatrienoic acids	259-284	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
30988740-4	2019	Epoxyeicosatrienoic acids (EETs) are natural anti-inflammatory factors and angiogenic mediators degraded by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	108-133
30988740-4	2019	Epoxyeicosatrienoic acids (EETs) are natural anti-inflammatory factors and angiogenic mediators degraded by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	135-138
31002701-1	2019	Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	142-147
31002701-1	2019	Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	149-168
31002701-1	2019	Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	205-208
30716359-3	2019	Recently, enhancing the concentration of epoxyeicosatrienoic acids (EETs) through blocking their hydrolytic degradation by soluble epoxide hydrolase (sEH) has been applied towards reducing the long-term damage associated with central neurologic insults.	epoxyeicosatrienoic acids	41-66	epoxide hydrolase 2	Homo sapiens	123-148
30716359-3	2019	Recently, enhancing the concentration of epoxyeicosatrienoic acids (EETs) through blocking their hydrolytic degradation by soluble epoxide hydrolase (sEH) has been applied towards reducing the long-term damage associated with central neurologic insults.	epoxyeicosatrienoic acids	41-66	epoxide hydrolase 2	Homo sapiens	150-153
30789748-2	2019	Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids, attenuating their cardiovascular protective effects.	epoxyeicosatrienoic acids	43-68	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
30789748-2	2019	Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids, attenuating their cardiovascular protective effects.	epoxyeicosatrienoic acids	43-68	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
30885203-1	2019	BACKGROUND: This pathophysiological study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes the vasodilator and anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), contributes to conduit artery endothelial dysfunction in type 2 diabetes.	epoxyeicosatrienoic acids	161-186	epoxide hydrolase 2	Homo sapiens	72-97
30885203-1	2019	BACKGROUND: This pathophysiological study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes the vasodilator and anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), contributes to conduit artery endothelial dysfunction in type 2 diabetes.	epoxyeicosatrienoic acids	161-186	epoxide hydrolase 2	Homo sapiens	99-102
30644034-5	2019	We found that TPPU and the sEH substrate epoxyeicosatrienoic acids (EETs) protected PC12 cells from the CORT-induced injury by increasing cell viability and inhibiting apoptosis.	epoxyeicosatrienoic acids	41-66	epoxide hydrolase 2	Rattus norvegicus	27-30
30644034-5	2019	We found that TPPU and the sEH substrate epoxyeicosatrienoic acids (EETs) protected PC12 cells from the CORT-induced injury by increasing cell viability and inhibiting apoptosis.	epoxyeicosatrienoic acids	41-66	cortistatin	Rattus norvegicus	104-108
30560267-4	2018	CYP450 epoxygenase metabolites epoxyeicosatrienoic acids (EETs) are mainly produced in renal microvessels.	epoxyeicosatrienoic acids	31-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-6
30518987-1	2019	This study investigated whether common polymorphisms of cytochrome P450 2J2 (CYP2J2), a major enzyme that controls the biosynthesis of vasoactive epoxyeicosatrienoic acids, are collectively involved in the molecular basis of essential hypertension (EH).	epoxyeicosatrienoic acids	146-171	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	56-75
30518987-1	2019	This study investigated whether common polymorphisms of cytochrome P450 2J2 (CYP2J2), a major enzyme that controls the biosynthesis of vasoactive epoxyeicosatrienoic acids, are collectively involved in the molecular basis of essential hypertension (EH).	epoxyeicosatrienoic acids	146-171	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	77-83
30728778-2	2019	Previous studies have shown that increasing kidney epoxyeicosatrienoic acids (EETs) by blocking soluble epoxide hydrolase (sEH), an enzyme responsible for EETs degradation, improves the survival rate in CHF induced by aorto-caval fistula (ACF) and attenuates CKD progression.	epoxyeicosatrienoic acids	51-76	epoxide hydrolase 2	Rattus norvegicus	96-121
30728778-2	2019	Previous studies have shown that increasing kidney epoxyeicosatrienoic acids (EETs) by blocking soluble epoxide hydrolase (sEH), an enzyme responsible for EETs degradation, improves the survival rate in CHF induced by aorto-caval fistula (ACF) and attenuates CKD progression.	epoxyeicosatrienoic acids	51-76	epoxide hydrolase 2	Rattus norvegicus	123-126
30420806-1	2018	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450 (CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	73-88
30400671-2	2018	Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), vasoactive and natriuretic metabolites that contribute to blood pressure (BP) regulation.	epoxyeicosatrienoic acids	76-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-55
30400671-2	2018	Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), vasoactive and natriuretic metabolites that contribute to blood pressure (BP) regulation.	epoxyeicosatrienoic acids	76-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	57-63
31430751-1	2019	OBJECTIVE: We evaluated the hypothesis that the development of renal dysfunction and congestive heart failure (CHF) caused by volume overload in rats with angiotensin II (ANG II)-dependent hypertension is associated with altered renal vascular responsiveness to ANG II and to epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	276-301	angiotensinogen	Rattus norvegicus	155-169
31430751-1	2019	OBJECTIVE: We evaluated the hypothesis that the development of renal dysfunction and congestive heart failure (CHF) caused by volume overload in rats with angiotensin II (ANG II)-dependent hypertension is associated with altered renal vascular responsiveness to ANG II and to epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	276-301	angiotensinogen	Rattus norvegicus	171-177
30420806-1	2018	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450 (CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	90-93
30420806-1	2018	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450 (CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	129-154
30420806-1	2018	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450 (CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	156-159
30365528-4	2018	Transient receptor potential vanilloid 4 (TRPV4) is activated by mechanical stimuli and some epoxyeicosatrienoic acids and becomes sensitized under inflammatory conditions.	epoxyeicosatrienoic acids	93-118	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	0-40
30365528-4	2018	Transient receptor potential vanilloid 4 (TRPV4) is activated by mechanical stimuli and some epoxyeicosatrienoic acids and becomes sensitized under inflammatory conditions.	epoxyeicosatrienoic acids	93-118	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	42-47
30047995-2	2018	Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) to less bioactive diols, and EETs have cardioprotective properties.	epoxyeicosatrienoic acids	43-68	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
30047995-2	2018	Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) to less bioactive diols, and EETs have cardioprotective properties.	epoxyeicosatrienoic acids	43-68	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
29717935-2	2018	Epoxyeicosatrienoic acids (EETs), which are rapidly metabolized to dihydroxyeicosatrienoic acids by the soluble epoxide hydrolase (sEH), have multiple biological functions, including vasodilation, anti-inflammatory action, and others.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	104-129
29717935-2	2018	Epoxyeicosatrienoic acids (EETs), which are rapidly metabolized to dihydroxyeicosatrienoic acids by the soluble epoxide hydrolase (sEH), have multiple biological functions, including vasodilation, anti-inflammatory action, and others.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	131-134
29851077-1	2018	BACKGROUND AND OBJECTIVE: Soluble epoxide hydrolase (sEH) is an enzyme in the arachidonate cascade which converts epoxy fatty acids (EpFAs), such as epoxyeicosatrienoic acids (EETs) produced by cytochrome P450 enzymes, to dihydroxy-eicosatrienoic acids.	epoxyeicosatrienoic acids	149-174	epoxide hydrolase 2, cytoplasmic	Mus musculus	26-51
29851077-1	2018	BACKGROUND AND OBJECTIVE: Soluble epoxide hydrolase (sEH) is an enzyme in the arachidonate cascade which converts epoxy fatty acids (EpFAs), such as epoxyeicosatrienoic acids (EETs) produced by cytochrome P450 enzymes, to dihydroxy-eicosatrienoic acids.	epoxyeicosatrienoic acids	149-174	epoxide hydrolase 2, cytoplasmic	Mus musculus	53-56
29580941-0	2018	Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression.	epoxyeicosatrienoic acids	10-35	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	118-124
29960002-1	2018	CYP epoxygenases metabolize arachidonic acid into four regioisomers of epoxyeicosatrienoic acids (EETs) which are hydrolysed into their corresponding diols by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	71-96	epoxide hydrolase 2	Homo sapiens	159-184
29960002-1	2018	CYP epoxygenases metabolize arachidonic acid into four regioisomers of epoxyeicosatrienoic acids (EETs) which are hydrolysed into their corresponding diols by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	71-96	epoxide hydrolase 2	Homo sapiens	186-189
30066055-2	2018	CYP-derived AA epoxides, called epoxyeicosatrienoic acids (EETs), also promote the growth of tumor epithelia.	epoxyeicosatrienoic acids	32-57	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
29908721-1	2018	CYP2C and CYP2 J enzymes, commonly named as cytochrome P450 (CYP) epoxygenases, convert arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs), biologically active eicosanoids with many functions in organism.	epoxyeicosatrienoic acids	127-152	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	44-59
29908721-1	2018	CYP2C and CYP2 J enzymes, commonly named as cytochrome P450 (CYP) epoxygenases, convert arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs), biologically active eicosanoids with many functions in organism.	epoxyeicosatrienoic acids	127-152	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
29569766-13	2018	CONCLUSIONS: LAL promoted cell proliferation and survival via metabolism of epoxyeicosatrienoic acids and activation of the Src/Akt pathway.	epoxyeicosatrienoic acids	76-101	lipase A, lysosomal acid type	Homo sapiens	13-16
29695613-1	2018	Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)-derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome P450 2J2 (CYP2J2).	epoxyeicosatrienoic acids	110-135	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	158-177
29695613-1	2018	Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)-derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome P450 2J2 (CYP2J2).	epoxyeicosatrienoic acids	110-135	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	179-185
29345370-3	2018	Soluble epoxide hydrolase (sEH) is known to play a pro-inflammatory role during inflammation by metabolizing anti-inflammatory epoxyeicosatrienoic acids (EETs) to pro-inflammatory diols.	epoxyeicosatrienoic acids	127-152	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
29345370-3	2018	Soluble epoxide hydrolase (sEH) is known to play a pro-inflammatory role during inflammation by metabolizing anti-inflammatory epoxyeicosatrienoic acids (EETs) to pro-inflammatory diols.	epoxyeicosatrienoic acids	127-152	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
30012669-1	2018	Increased expression of cytochrome P450 CYP2C9, together with elevated levels of its products epoxyeicosatrienoic acids (EET), is associated with aggressiveness in cancer.	epoxyeicosatrienoic acids	94-119	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	40-46
29361048-2	2018	Cytochrome P(CYP)-450 enzymes metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acids.	epoxyeicosatrienoic acids	61-86	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	13-16
29527914-1	2018	We showed recently that increasing kidney epoxyeicosatrienoic acids (EETs) by blocking soluble epoxide hydrolase (sEH), an enzyme responsible for EETs degradation, retarded the development of renal dysfunction and progression of aorto-caval fistula(ACF)-induced congestive heart failure (CHF) in Ren-2 transgenic hypertensive rats (TGR).	epoxyeicosatrienoic acids	42-67	epoxide hydrolase 2	Rattus norvegicus	87-112
29527914-1	2018	We showed recently that increasing kidney epoxyeicosatrienoic acids (EETs) by blocking soluble epoxide hydrolase (sEH), an enzyme responsible for EETs degradation, retarded the development of renal dysfunction and progression of aorto-caval fistula(ACF)-induced congestive heart failure (CHF) in Ren-2 transgenic hypertensive rats (TGR).	epoxyeicosatrienoic acids	42-67	epoxide hydrolase 2	Rattus norvegicus	114-117
29615440-1	2018	EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids.	epoxyeicosatrienoic acids	78-103	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-5
29615440-1	2018	EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids.	epoxyeicosatrienoic acids	78-103	epoxide hydrolase 2, cytoplasmic	Mus musculus	16-41
29615440-1	2018	EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids.	epoxyeicosatrienoic acids	78-103	epoxide hydrolase 2, cytoplasmic	Mus musculus	43-46
29715548-4	2018	In the current study, we tested the NO-mediated regulation of CYP2J2 that metabolizes arachidonic acids to bioactive epoxyeicosatrienoic acids, as well as therapeutic drugs such as astemizole and ebastine.	epoxyeicosatrienoic acids	117-142	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	62-68
29574653-8	2018	Moreover, the levels of epoxyeicosatrienoic acids and heme oxygenase-1 activity were notably elevated in sEH-/- mice compared with those in wild-type mice after exposure to 100% O2 for 72 h. The nucleotide-binding domains and leucine-rich repeat pyrin domains containing 3 (NLRP3) inflammasome activation and caspase-1 activity induced by hyperoxia were inhibited in sEH-/- mice compared with those in wild-type mice.	epoxyeicosatrienoic acids	24-49	epoxide hydrolase 2, cytoplasmic	Mus musculus	105-108
29580941-0	2018	Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression.	epoxyeicosatrienoic acids	10-35	epoxide hydrolase 2	Homo sapiens	137-162
29427791-2	2018	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acids to form epoxyeicosatrienoic acids (EETs), which exert beneficial roles in the cardiovascular system, but their role in alcoholic cardiomyopathy is elusive.	epoxyeicosatrienoic acids	72-97	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
29290096-2	2018	CYP-450 epoxygenase metabolizes AA to epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	38-63	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-7
29588470-1	2018	Epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 epoxygenases from arachidonic acid, and their rapid metabolism is mainly through soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	146-171
29588470-1	2018	Epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 epoxygenases from arachidonic acid, and their rapid metabolism is mainly through soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	173-176
29427791-2	2018	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acids to form epoxyeicosatrienoic acids (EETs), which exert beneficial roles in the cardiovascular system, but their role in alcoholic cardiomyopathy is elusive.	epoxyeicosatrienoic acids	72-97	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	17-20
29433675-2	2018	CYP2J2 inhibitors can significantly reduce proliferation, migration and promote apoptosis of tumor cells by inhibiting epoxyeicosatrienoic acids (EETs) biosynthesis.	epoxyeicosatrienoic acids	119-144	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
29311641-1	2018	Inhibition and deletion of soluble epoxide hydrolase (sEH) has been suggested to ameliorate infarction in experimental ischemic stroke possibly via vasoactive epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	159-184	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-52
29311641-1	2018	Inhibition and deletion of soluble epoxide hydrolase (sEH) has been suggested to ameliorate infarction in experimental ischemic stroke possibly via vasoactive epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	159-184	epoxide hydrolase 2, cytoplasmic	Mus musculus	54-57
28958841-1	2017	Cardiac enzymes such as cytochrome P450 2J2 (CYP2J2) metabolize arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs), which in turn are metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	106-131	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	24-43
29529602-1	2018	BACKGROUND/AIMS: We found recently that increasing renal epoxyeicosatrienoic acids (EETs) levels by blocking soluble epoxide hydrolase (sEH), an enzyme responsible for EETs degradation, shows renoprotective actions and retards the progression of chronic kidney disease (CKD) in Ren-2 transgenic hypertensive rats (TGR) after 5/6 renal ablation (5/6 NX).	epoxyeicosatrienoic acids	57-82	epoxide hydrolase 2	Rattus norvegicus	109-134
29529602-1	2018	BACKGROUND/AIMS: We found recently that increasing renal epoxyeicosatrienoic acids (EETs) levels by blocking soluble epoxide hydrolase (sEH), an enzyme responsible for EETs degradation, shows renoprotective actions and retards the progression of chronic kidney disease (CKD) in Ren-2 transgenic hypertensive rats (TGR) after 5/6 renal ablation (5/6 NX).	epoxyeicosatrienoic acids	57-82	epoxide hydrolase 2	Rattus norvegicus	136-139
28958841-1	2017	Cardiac enzymes such as cytochrome P450 2J2 (CYP2J2) metabolize arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs), which in turn are metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	106-131	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	45-51
28958841-1	2017	Cardiac enzymes such as cytochrome P450 2J2 (CYP2J2) metabolize arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs), which in turn are metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	106-131	epoxide hydrolase 2	Homo sapiens	173-198
28958841-1	2017	Cardiac enzymes such as cytochrome P450 2J2 (CYP2J2) metabolize arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs), which in turn are metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	106-131	epoxide hydrolase 2	Homo sapiens	200-203
28919040-2	2017	CYP3A4 was unexpectedly associated with breast cancer mitochondria and synthesized arachidonic acid (AA)-derived epoxyeicosatrienoic acids (EETs), which promoted the electron transport chain/respiration and inhibited AMPKalpha.	epoxyeicosatrienoic acids	113-138	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
28835580-0	2017	Epoxyeicosatrienoic Acids are Mediated by EPHX2 Variants and may be a Predictor of Early Neurological Deterioration in Acute Minor Ischemic Stroke.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	42-47
29285425-1	2017	Background: Soluble epoxide hydrolase (sEH) expressed by endothelial cells catalyzes the metabolism of epoxyeicosatrienoic acids (EETs), which are vasoactive agents.	epoxyeicosatrienoic acids	103-128	epoxide hydrolase 2	Homo sapiens	12-37
29285425-1	2017	Background: Soluble epoxide hydrolase (sEH) expressed by endothelial cells catalyzes the metabolism of epoxyeicosatrienoic acids (EETs), which are vasoactive agents.	epoxyeicosatrienoic acids	103-128	epoxide hydrolase 2	Homo sapiens	39-42
29178914-2	2017	Soluble epoxide hydrolase (sEH) is known to induce neuroinflammatory responses via degradation of anti-inflammatory epoxyeicosatrienoic acids (EET), and sEH is upregulated in response to brain injury.	epoxyeicosatrienoic acids	116-141	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
29178914-2	2017	Soluble epoxide hydrolase (sEH) is known to induce neuroinflammatory responses via degradation of anti-inflammatory epoxyeicosatrienoic acids (EET), and sEH is upregulated in response to brain injury.	epoxyeicosatrienoic acids	116-141	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
28741242-1	2017	A still growing body of evidence suggests the importance of epoxyeicosatrienoic acids (EETs) in the regulation of inflammatory response; therefore, drugs that stabilize their levels by targeting the soluble epoxide hydrolase (sEH), an enzyme responsible for their metabolism, are currently under investigation.	epoxyeicosatrienoic acids	60-85	epoxide hydrolase 2	Rattus norvegicus	199-224
28741242-1	2017	A still growing body of evidence suggests the importance of epoxyeicosatrienoic acids (EETs) in the regulation of inflammatory response; therefore, drugs that stabilize their levels by targeting the soluble epoxide hydrolase (sEH), an enzyme responsible for their metabolism, are currently under investigation.	epoxyeicosatrienoic acids	60-85	epoxide hydrolase 2	Rattus norvegicus	226-229
28874838-1	2017	TRPV4 cation channel activation by cytochrome P450-mediated derivatives of arachidonic acid (AA), epoxyeicosatrienoic acids (EETs), constitute a major mechanisms of endothelium-derived vasodilatation.	epoxyeicosatrienoic acids	98-123	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
28374982-1	2017	Cytochrome P450 (CYP) 2C9, CYP2C8 and CYP2J2 enzymes, which metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids, have cardioprotective effects including anti-inflammation and vasodilation.	epoxyeicosatrienoic acids	96-121	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	0-25
28374982-1	2017	Cytochrome P450 (CYP) 2C9, CYP2C8 and CYP2J2 enzymes, which metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids, have cardioprotective effects including anti-inflammation and vasodilation.	epoxyeicosatrienoic acids	96-121	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	27-33
28374982-1	2017	Cytochrome P450 (CYP) 2C9, CYP2C8 and CYP2J2 enzymes, which metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids, have cardioprotective effects including anti-inflammation and vasodilation.	epoxyeicosatrienoic acids	96-121	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	38-44
28798352-3	2017	Soluble epoxide hydrolase (sEH) is an endogenous key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	131-156	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
28839250-2	2017	Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	208-233	arachidonate 5-lipoxygenase	Homo sapiens	12-26
28839250-2	2017	Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	208-233	arachidonate 5-lipoxygenase activating protein	Homo sapiens	47-51
28839250-2	2017	Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	208-233	arachidonate 5-lipoxygenase	Homo sapiens	82-96
28839250-2	2017	Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	208-233	arachidonate 5-lipoxygenase	Homo sapiens	98-103
28839250-2	2017	Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	208-233	epoxide hydrolase 2	Homo sapiens	149-174
28839250-2	2017	Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	208-233	epoxide hydrolase 2	Homo sapiens	176-179
28736260-2	2017	Here we found soluble epoxide hydrolase (sEH), which metabolizes cardioprotective epoxyeicosatrienoic acids into less effective diols, was rapidly activated during myocardial reperfusion in both mouse and rat models in expression-independent manner.	epoxyeicosatrienoic acids	82-107	epoxide hydrolase 2, cytoplasmic	Mus musculus	14-39
28736260-2	2017	Here we found soluble epoxide hydrolase (sEH), which metabolizes cardioprotective epoxyeicosatrienoic acids into less effective diols, was rapidly activated during myocardial reperfusion in both mouse and rat models in expression-independent manner.	epoxyeicosatrienoic acids	82-107	epoxide hydrolase 2, cytoplasmic	Mus musculus	41-44
28798352-3	2017	Soluble epoxide hydrolase (sEH) is an endogenous key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	131-156	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
28411230-9	2017	Deletion of 12/15-LOX in mice led to increased cytochrome P-450-derived bioactive lipid mediator epoxyeicosatrienoic acids (EETs), i.e., 11,12-EpETrE and 14,15-EpETrE, which were further enhanced by acute PUFA intake post-MI.	epoxyeicosatrienoic acids	97-122	arachidonate 15-lipoxygenase	Mus musculus	18-21
28554983-0	2017	CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Galpha12/13.	epoxyeicosatrienoic acids	20-45	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	57-63
28237650-2	2017	CYP2J2 is a major cardiac CYP450 and primarily metabolizes polyunsaturated fatty acids such as arachidonic acid to cardioactive epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	128-153	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
28554983-0	2017	CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Galpha12/13.	epoxyeicosatrienoic acids	20-45	guanine nucleotide binding protein, alpha 12	Mus musculus	111-119
28319086-1	2017	Epoxyeicosatrienoic acids (EETs) are the epoxidation products of arachidonic acid catalyzed by cytochrome P450 (CYP) epoxygenases, which possess multiple biological activities.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	95-110
28319086-1	2017	Epoxyeicosatrienoic acids (EETs) are the epoxidation products of arachidonic acid catalyzed by cytochrome P450 (CYP) epoxygenases, which possess multiple biological activities.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	112-115
28890385-2	2017	Adenosine A2AAR-deficient (A2AAR-/-) mice have increased expression of soluble epoxide hydrolase (sEH); the enzyme responsible for breaking down the cardioprotective epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	166-191	adenosine A2a receptor	Mus musculus	10-15
28473204-3	2017	Cirrhotic tissues had a higher ratio of epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs) following increased CYP2C11 expression, which may be a protective response.	epoxyeicosatrienoic acids	40-65	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	134-141
28890385-2	2017	Adenosine A2AAR-deficient (A2AAR-/-) mice have increased expression of soluble epoxide hydrolase (sEH); the enzyme responsible for breaking down the cardioprotective epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	166-191	adenosine A2a receptor	Mus musculus	27-35
28890385-2	2017	Adenosine A2AAR-deficient (A2AAR-/-) mice have increased expression of soluble epoxide hydrolase (sEH); the enzyme responsible for breaking down the cardioprotective epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	166-191	epoxide hydrolase 2, cytoplasmic	Mus musculus	71-96
28890385-2	2017	Adenosine A2AAR-deficient (A2AAR-/-) mice have increased expression of soluble epoxide hydrolase (sEH); the enzyme responsible for breaking down the cardioprotective epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	166-191	epoxide hydrolase 2, cytoplasmic	Mus musculus	98-101
28713267-2	2017	Epoxyeicosatrienoic acids (EETs) are Cyp epoxygenase arachidonic acid metabolites that demonstrate biological actions that result in kidney protection.	epoxyeicosatrienoic acids	0-25	peptidyl-prolyl isomerase G (cyclophilin G)	Mus musculus	37-40
28352940-0	2017	Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans.	epoxyeicosatrienoic acids	36-61	insulin	Homo sapiens	76-83
28007573-1	2017	OBJECTIVE: Prominent among the endothelium-derived hyperpolarizing factors (EDHFs) are the Cytochrome P450 (CYP) epoxygenase-derived arachidonic acid metabolites-the epoxyeicosatrienoic acids (EETs), that are known as vasodilators in the microcirculation.	epoxyeicosatrienoic acids	166-191	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	91-106
28356494-1	2017	Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid derived from the cytochrome P450 enzymes, are mainly metabolized by soluble epoxide hydrolase (sEH) to their corresponding diols.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	134-159
28707660-2	2017	The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators.	epoxyeicosatrienoic acids	41-66	epoxide hydrolase 2	Rattus norvegicus	4-7
28616567-2	2017	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	72-79
27782740-2	2017	Recent studies have revealed striking differences in the role of epoxyeicosatrienoic acids (EETs), active products of cytochrome P-450-dependent epoxygenase pathway of arachidonic acid, in the progression of aorto-caval fistula (ACF)-induced CHF between hypertensive Ren-2 renin transgenic rats (TGR) and transgene-negative normotensive Hannover Sprague-Dawley (HanSD) controls.	epoxyeicosatrienoic acids	65-90	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	118-134
28002622-1	2017	Epoxyeicosatrienoic acids (EETs) are synthesized in astrocytes, and inhibitors of soluble epoxide hydrolase (sEH), which hydrolyzes EETs, reduce infarct volume in ischemic stroke.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	82-107
28002622-1	2017	Epoxyeicosatrienoic acids (EETs) are synthesized in astrocytes, and inhibitors of soluble epoxide hydrolase (sEH), which hydrolyzes EETs, reduce infarct volume in ischemic stroke.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	109-112
28218273-4	2017	The soluble epoxide hydrolase (sEH) converts AA-derived anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatetraenoic acids (di-HETEs).	epoxyeicosatrienoic acids	74-99	epoxide hydrolase 2	Homo sapiens	4-29
28218273-4	2017	The soluble epoxide hydrolase (sEH) converts AA-derived anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatetraenoic acids (di-HETEs).	epoxyeicosatrienoic acids	74-99	epoxide hydrolase 2	Homo sapiens	31-34
28007573-1	2017	OBJECTIVE: Prominent among the endothelium-derived hyperpolarizing factors (EDHFs) are the Cytochrome P450 (CYP) epoxygenase-derived arachidonic acid metabolites-the epoxyeicosatrienoic acids (EETs), that are known as vasodilators in the microcirculation.	epoxyeicosatrienoic acids	166-191	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	108-111
28332266-1	2017	Epoxyeicosatrienoic acids (EETs) are endogenous ligands that undergo hydrolysis by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	83-108
28332266-1	2017	Epoxyeicosatrienoic acids (EETs) are endogenous ligands that undergo hydrolysis by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	110-113
29138698-1	2017	Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid and metabolized by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	86-111
29138698-1	2017	Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid and metabolized by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	113-116
27087514-1	2016	AIM: To better understand the relationship between the interactions among rs17110453, rs751141, and rs9333025 variants and plasma levels of cytochrome P450 (CYP) metabolites, i.e.,20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DiHETEs) in ischemia stroke (IS).	epoxyeicosatrienoic acids	223-248	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	157-160
27966642-3	2016	In TNFalpha-stimulated primary human retinal microvascular endothelial cells, total levels of epoxyeicosatrienoic acids (EETs), but not epoxydocosapentaenoic acids (EDPs), were significantly decreased.	epoxyeicosatrienoic acids	94-119	tumor necrosis factor	Homo sapiens	3-11
27663770-2	2016	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	72-79
28293507-4	2016	Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are inactivated by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	109-134
27815261-3	2016	Epoxyeicosatrienoic acids (EETs) are pulmonary vasoconstrictors, which are metabolized to less vasoactive dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	147-172
27815261-3	2016	Epoxyeicosatrienoic acids (EETs) are pulmonary vasoconstrictors, which are metabolized to less vasoactive dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	174-177
27924507-3	2016	Inhibition of soluble epoxide hydrolase (sEH) metabolism has been shown to effectively increase the accumulation of epoxyeicosatrienoic acids (EETs), which are cytochrome P450 metabolites of arachidonic acid and have been demonstrated to have neuroprotective effects.	epoxyeicosatrienoic acids	116-141	epoxide hydrolase 2	Homo sapiens	14-39
27924507-3	2016	Inhibition of soluble epoxide hydrolase (sEH) metabolism has been shown to effectively increase the accumulation of epoxyeicosatrienoic acids (EETs), which are cytochrome P450 metabolites of arachidonic acid and have been demonstrated to have neuroprotective effects.	epoxyeicosatrienoic acids	116-141	epoxide hydrolase 2	Homo sapiens	41-44
27591243-1	2016	Epoxyeicosatrienoic acids (EETs) are metabolic products of free arachidonic acid, which are produced through cytochrome P-450 (CYP) epoxygenases.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	109-125
27591243-1	2016	Epoxyeicosatrienoic acids (EETs) are metabolic products of free arachidonic acid, which are produced through cytochrome P-450 (CYP) epoxygenases.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	127-130
26975734-1	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to generate epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	75-100	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
27629787-1	2016	Soluble epoxide hydrolase (sEH) converts epoxyeicosatrienoic acids that are endothelium-derived hyperpolarizing factors into less active dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	41-66	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
27629787-1	2016	Soluble epoxide hydrolase (sEH) converts epoxyeicosatrienoic acids that are endothelium-derived hyperpolarizing factors into less active dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	41-66	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
26975734-1	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to generate epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	75-100	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
27115337-1	2016	BACKGROUND: Epoxyeicosatrienoic acids (EETs) derived from cytochrome P450 (CYP)-dependent metabolism of arachidonic acid are increased in the plasma of women with preeclampsia as compared with normal pregnancy and are significantly higher in fetal than in maternal plasma and erythrocytes.	epoxyeicosatrienoic acids	12-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	58-73
27416746-0	2016	CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPKalpha2 and enhancing nuclear translocation of Akt1.	epoxyeicosatrienoic acids	28-53	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	99-109
27416746-0	2016	CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPKalpha2 and enhancing nuclear translocation of Akt1.	epoxyeicosatrienoic acids	28-53	thymoma viral proto-oncogene 1	Mus musculus	149-153
27416746-1	2016	Cytochrome P450 epoyxgenase 2J2 and epoxyeicosatrienoic acids (EETs) are known to protect against cardiac hypertrophy and heart failure, which involve the activation of 5"-AMP-activated protein kinase (AMPK) and Akt.	epoxyeicosatrienoic acids	36-61	thymoma viral proto-oncogene 1	Mus musculus	212-215
27358055-5	2016	Cytochrome P-450 epoxygenase metabolites of arachidonic acid, epoxyeicosatrienoic acids (EETs), have potent vasodilator and antihypertensive properties in addition to many cytoprotective effects, but their effects on CNI-induced nephrotoxicity have not been explored.	epoxyeicosatrienoic acids	62-87	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
27496380-2	2016	Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid, are known to have anti-inflammatory effects and are hydrolyzed by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	133-158
27496380-2	2016	Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid, are known to have anti-inflammatory effects and are hydrolyzed by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	160-163
27401401-2	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into bioactive epoxyeicosatrienoic acids (EETs), which have potent anti-inflammatory and protective effects.	epoxyeicosatrienoic acids	78-103	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-15
27401401-2	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into bioactive epoxyeicosatrienoic acids (EETs), which have potent anti-inflammatory and protective effects.	epoxyeicosatrienoic acids	78-103	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	17-20
27448715-5	2016	Pharmacological inhibition of epoxide hydrolase or deletion of the gene encoding soluble epoxide hydrolase (Ephx2) preserves islet cells in rodent models of type 1 diabetes and enhances insulin sensitivity in models of type 2 diabetes, as does administration of epoxyeicosatrienoic acids or their stable analogues.	epoxyeicosatrienoic acids	262-287	epoxide hydrolase 2	Homo sapiens	108-113
27448715-6	2016	In humans, circulating concentrations of epoxyeicosatrienoic acids correlate with insulin sensitivity, and a loss-of-function genetic polymorphism in EPHX2 is associated with insulin sensitivity.	epoxyeicosatrienoic acids	41-66	epoxide hydrolase 2	Homo sapiens	150-155
27252474-7	2016	Similar results were obtained with the administration of miconazole, which inhibits the biosynthesis of epoxyeicosatrienoic acids (EETs), endogenous agonists for TRPV4, from arachidonic acid (AA).	epoxyeicosatrienoic acids	104-129	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	162-167
27583776-3	2016	sEH is involved in the main catabolic pathway of epoxyeicosatrienoic acids (EETs), which are converted into dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	49-74	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
27092411-1	2016	Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) in the metabolic pathway of arachidonic acid and has been considered as an important therapeutic target for chronic diseases such as hypertension, diabetes and inflammation.	epoxyeicosatrienoic acids	43-68	epoxide hydrolase 2	Homo sapiens	0-25
27092411-1	2016	Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) in the metabolic pathway of arachidonic acid and has been considered as an important therapeutic target for chronic diseases such as hypertension, diabetes and inflammation.	epoxyeicosatrienoic acids	43-68	epoxide hydrolase 2	Homo sapiens	27-30
27224420-0	2016	Epoxyeicosatrienoic Acids Regulate Adipocyte Differentiation of Mouse 3T3 Cells, Via PGC-1alpha Activation, Which Is Required for HO-1 Expression and Increased Mitochondrial Function.	epoxyeicosatrienoic acids	0-25	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	85-95
27115337-1	2016	BACKGROUND: Epoxyeicosatrienoic acids (EETs) derived from cytochrome P450 (CYP)-dependent metabolism of arachidonic acid are increased in the plasma of women with preeclampsia as compared with normal pregnancy and are significantly higher in fetal than in maternal plasma and erythrocytes.	epoxyeicosatrienoic acids	12-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	75-78
27100515-1	2016	Cytochrome P450s enzymes catalyze the metabolism of arachidonic acid to epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid and hydroxyeicosatetraeonic acid (HETEs).	epoxyeicosatrienoic acids	72-97	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
27375480-2	2016	This study investigated the hypothesis that inhibiting soluble epoxide hydrolase (sEH), responsible for converting epoxyeicosatrienoic acids to dihydroxyeicosatrienoic acids protects mitochondrial from injury caused by myocardial infarction.	epoxyeicosatrienoic acids	115-140	epoxide hydrolase 2, cytoplasmic	Mus musculus	55-80
27375480-2	2016	This study investigated the hypothesis that inhibiting soluble epoxide hydrolase (sEH), responsible for converting epoxyeicosatrienoic acids to dihydroxyeicosatrienoic acids protects mitochondrial from injury caused by myocardial infarction.	epoxyeicosatrienoic acids	115-140	epoxide hydrolase 2, cytoplasmic	Mus musculus	82-85
27016584-1	2016	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via CYP/epoxygenases, which are catabolized by soluble epoxide hydrolase (sEH) and known to possess cardioprotective properties.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	116-141
27016584-1	2016	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via CYP/epoxygenases, which are catabolized by soluble epoxide hydrolase (sEH) and known to possess cardioprotective properties.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	143-146
26620151-1	2016	AIMS: Endothelial-derived epoxyeicosatrienoic acids may regulate vascular tone and are metabolized by soluble epoxide hydrolase enzymes (sEH).	epoxyeicosatrienoic acids	26-51	epoxide hydrolase 2	Homo sapiens	102-135
26859195-1	2016	AIMS: The aim of the present study was to investigate how cytochrome P450 (CYP)2J2-derived epoxyeicosatrienoic acids (EETs) regulate the AKT1 and FOXO1 and BIM pathway and protect against endothelial apoptosis in the development and progression of atherosclerosis.	epoxyeicosatrienoic acids	91-116	thymoma viral proto-oncogene 1	Mus musculus	137-141
26859195-1	2016	AIMS: The aim of the present study was to investigate how cytochrome P450 (CYP)2J2-derived epoxyeicosatrienoic acids (EETs) regulate the AKT1 and FOXO1 and BIM pathway and protect against endothelial apoptosis in the development and progression of atherosclerosis.	epoxyeicosatrienoic acids	91-116	forkhead box O1	Mus musculus	146-151
27354541-1	2016	Epoxyeicosatrienoic acids (EETs) are cardioprotective mediators metabolized by soluble epoxide hydrolase (sEH) to form corresponding diols (DHETs).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	79-104
27354541-1	2016	Epoxyeicosatrienoic acids (EETs) are cardioprotective mediators metabolized by soluble epoxide hydrolase (sEH) to form corresponding diols (DHETs).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	106-109
26686738-3	2016	CYP plasma metabolite levels [20-hydroxyeicosatetraenoic acid (HETE), total epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DiHETEs)] were assessed in a subsample of 90 patients with carotid stenosis and 96 patients without carotid stenosis.	epoxyeicosatrienoic acids	76-101	peptidylprolyl isomerase G	Homo sapiens	0-3
26918316-1	2016	Cytochrome P450 (P450) enzymes metabolize arachidonic acid (AA) to several biologically active epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs).	epoxyeicosatrienoic acids	95-120	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-21
25663200-3	2016	Soluble epoxide hydrolase (sEH) is an endogenous key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	131-156	epoxide hydrolase 2	Rattus norvegicus	0-25
25663200-3	2016	Soluble epoxide hydrolase (sEH) is an endogenous key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	131-156	epoxide hydrolase 2	Rattus norvegicus	27-30
26845235-1	2016	Soluble epoxide hydrolase (sEH) is involved in the regulation of many biological processes by metabolizing the key bioactive lipid mediator, epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	141-166	epoxide hydrolase 2	Homo sapiens	0-25
26845235-1	2016	Soluble epoxide hydrolase (sEH) is involved in the regulation of many biological processes by metabolizing the key bioactive lipid mediator, epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	141-166	epoxide hydrolase 2	Homo sapiens	27-30
26838069-1	2016	AIM: CYP2J3 in myocardium metabolizes arachidonic acid to 4 regioisomeric epoxyeicosatrienoic acids (EETs), which have diverse biological activities in rat heart.	epoxyeicosatrienoic acids	74-99	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	5-11
27224420-0	2016	Epoxyeicosatrienoic Acids Regulate Adipocyte Differentiation of Mouse 3T3 Cells, Via PGC-1alpha Activation, Which Is Required for HO-1 Expression and Increased Mitochondrial Function.	epoxyeicosatrienoic acids	0-25	heme oxygenase 1	Mus musculus	130-134
26621325-2	2016	Epoxyeicosatrienoic acids can be further hydrolyzed to less active diols by the enzyme soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	87-112
26621325-2	2016	Epoxyeicosatrienoic acids can be further hydrolyzed to less active diols by the enzyme soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	114-117
26882208-1	2016	There is an increasing interest in the development of soluble epoxide hydrolase (sEH) inhibitors, which block the degradation of endogenous anti-inflammatory epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	158-183	epoxide hydrolase 2	Homo sapiens	54-79
26882208-1	2016	There is an increasing interest in the development of soluble epoxide hydrolase (sEH) inhibitors, which block the degradation of endogenous anti-inflammatory epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	158-183	epoxide hydrolase 2	Homo sapiens	81-84
26222277-7	2016	PAF induced formation of epoxyeicosatrienoic acids by neutrophils, which, in turn, stimulated TRPV4-dependent Ca(2+) signaling, whereas inhibition of epoxyeicosatrienoic acid formation inhibited the Ca(2+) response to PAF.	epoxyeicosatrienoic acids	25-50	patchy fur	Mus musculus	0-3
26222277-7	2016	PAF induced formation of epoxyeicosatrienoic acids by neutrophils, which, in turn, stimulated TRPV4-dependent Ca(2+) signaling, whereas inhibition of epoxyeicosatrienoic acid formation inhibited the Ca(2+) response to PAF.	epoxyeicosatrienoic acids	25-50	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	94-99
26222277-7	2016	PAF induced formation of epoxyeicosatrienoic acids by neutrophils, which, in turn, stimulated TRPV4-dependent Ca(2+) signaling, whereas inhibition of epoxyeicosatrienoic acid formation inhibited the Ca(2+) response to PAF.	epoxyeicosatrienoic acids	25-50	patchy fur	Mus musculus	218-221
26620151-1	2016	AIMS: Endothelial-derived epoxyeicosatrienoic acids may regulate vascular tone and are metabolized by soluble epoxide hydrolase enzymes (sEH).	epoxyeicosatrienoic acids	26-51	epoxide hydrolase 2	Homo sapiens	137-140
26683769-3	2016	The soluble epoxide hydrolase (sEH), a pro-inflammatory enzyme, generally inactivates anti-inflammatory and anti-pain epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	118-143	epoxide hydrolase 2, cytoplasmic	Mus musculus	4-29
26683769-3	2016	The soluble epoxide hydrolase (sEH), a pro-inflammatory enzyme, generally inactivates anti-inflammatory and anti-pain epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	118-143	epoxide hydrolase 2, cytoplasmic	Mus musculus	31-34
26310139-1	2016	Epoxyeicosatrienoic acids (EETs), the metabolites of arachidonic acid derived from the cytochrome P450 (CYP450) epoxygenases, are mainly metabolized by soluble epoxide hydrolase (sEH) to their corresponding diols.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	152-177
26310139-1	2016	Epoxyeicosatrienoic acids (EETs), the metabolites of arachidonic acid derived from the cytochrome P450 (CYP450) epoxygenases, are mainly metabolized by soluble epoxide hydrolase (sEH) to their corresponding diols.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	179-182
26545915-3	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active eicosanoids called epoxyeicosatrienoic acids (EETs), which are further converted by soluble epoxide hydrolase (sEH) to less bioactive diols.	epoxyeicosatrienoic acids	105-130	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
26545915-3	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active eicosanoids called epoxyeicosatrienoic acids (EETs), which are further converted by soluble epoxide hydrolase (sEH) to less bioactive diols.	epoxyeicosatrienoic acids	105-130	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	17-20
26545915-3	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active eicosanoids called epoxyeicosatrienoic acids (EETs), which are further converted by soluble epoxide hydrolase (sEH) to less bioactive diols.	epoxyeicosatrienoic acids	105-130	epoxide hydrolase 2	Rattus norvegicus	170-195
26545915-3	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active eicosanoids called epoxyeicosatrienoic acids (EETs), which are further converted by soluble epoxide hydrolase (sEH) to less bioactive diols.	epoxyeicosatrienoic acids	105-130	epoxide hydrolase 2	Rattus norvegicus	197-200
26727266-1	2016	AIM: 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-dependent eicosanoids that play opposite roles in the regulation of vascular tone, inflammation, and apoptosis.	epoxyeicosatrienoic acids	51-76	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	88-103
26727266-1	2016	AIM: 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-dependent eicosanoids that play opposite roles in the regulation of vascular tone, inflammation, and apoptosis.	epoxyeicosatrienoic acids	51-76	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	105-108
26722025-2	2016	In the process of long-standing chronic inflammation, aberrant metabolites of arachidonic acid play a crucial role in promoting carcinogenesis, in which the soluble epoxide hydrolase (sEH), as a pro-inflammatory enzyme, generally inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	260-285	epoxide hydrolase 2, cytoplasmic	Mus musculus	157-182
27451096-3	2016	The CYP pathway produces two types of eicosanoid products: epoxyeicosatrienoic acids (EETs), formed by CYP epoxygenases, and hydroxyeicosatetraenoic acids (HETEs), formed by CYP hydroxylases.	epoxyeicosatrienoic acids	59-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-7
27451096-3	2016	The CYP pathway produces two types of eicosanoid products: epoxyeicosatrienoic acids (EETs), formed by CYP epoxygenases, and hydroxyeicosatetraenoic acids (HETEs), formed by CYP hydroxylases.	epoxyeicosatrienoic acids	59-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-106
27451096-3	2016	The CYP pathway produces two types of eicosanoid products: epoxyeicosatrienoic acids (EETs), formed by CYP epoxygenases, and hydroxyeicosatetraenoic acids (HETEs), formed by CYP hydroxylases.	epoxyeicosatrienoic acids	59-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-106
27144772-1	2016	Soluble epoxide hydrolase (sEH) converts highly active epoxyeicosatrienoic acids (EETs) generated by cytochrome P450 (CYP) epoxygenases from arachidonic acid to less active dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	55-80	epoxide hydrolase 2	Homo sapiens	0-25
27144772-1	2016	Soluble epoxide hydrolase (sEH) converts highly active epoxyeicosatrienoic acids (EETs) generated by cytochrome P450 (CYP) epoxygenases from arachidonic acid to less active dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	55-80	epoxide hydrolase 2	Homo sapiens	27-30
27144772-1	2016	Soluble epoxide hydrolase (sEH) converts highly active epoxyeicosatrienoic acids (EETs) generated by cytochrome P450 (CYP) epoxygenases from arachidonic acid to less active dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	55-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	101-116
27144772-1	2016	Soluble epoxide hydrolase (sEH) converts highly active epoxyeicosatrienoic acids (EETs) generated by cytochrome P450 (CYP) epoxygenases from arachidonic acid to less active dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	55-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	118-121
26747234-7	2016	Several elegant studies have contributed to defining the importance of stabilizing the levels of epoxyeicosatrienoic acids (EETs), by inhibiting or deleting soluble epoxide hydrolase (sEH), in stroke research.	epoxyeicosatrienoic acids	97-122	epoxide hydrolase 2	Homo sapiens	157-182
26467040-2	2016	CYP2C8, an important member of this subfamily, metabolizes the anticancer drug paclitaxel, certain antidiabetic drugs, and endogenous substrates, including arachidonic acid, to physiologically active epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	200-225	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	0-6
26722025-2	2016	In the process of long-standing chronic inflammation, aberrant metabolites of arachidonic acid play a crucial role in promoting carcinogenesis, in which the soluble epoxide hydrolase (sEH), as a pro-inflammatory enzyme, generally inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	260-285	epoxide hydrolase 2, cytoplasmic	Mus musculus	184-187
26322503-6	2015	Serum levels of epoxyeicosatrienoic acids (EETs) and its mainly metabolic enzyme-soluble epoxide hydrolase (sEH) were measured.	epoxyeicosatrienoic acids	16-41	epoxide hydrolase 2	Homo sapiens	108-111
26453332-1	2015	We hypothesized that potentiating the bioavailability of endothelial epoxyeicosatrienoic acids (EETs) via deletion of the gene for soluble epoxide hydrolase (sEH), or downregulation of sEH expression, enhances flow/shear stress-induced dilator responses (FID) of arterioles.	epoxyeicosatrienoic acids	69-94	epoxide hydrolase 2, cytoplasmic	Mus musculus	131-156
26453332-1	2015	We hypothesized that potentiating the bioavailability of endothelial epoxyeicosatrienoic acids (EETs) via deletion of the gene for soluble epoxide hydrolase (sEH), or downregulation of sEH expression, enhances flow/shear stress-induced dilator responses (FID) of arterioles.	epoxyeicosatrienoic acids	69-94	epoxide hydrolase 2, cytoplasmic	Mus musculus	158-161
26494028-1	2015	BACKGROUND: The soluble epoxide hydrolase (sEH) is an important enzyme chiefly involved in the metabolism of fatty acid signaling molecules termed epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	147-172	epoxide hydrolase 2, cytoplasmic	Mus musculus	16-41
26494028-1	2015	BACKGROUND: The soluble epoxide hydrolase (sEH) is an important enzyme chiefly involved in the metabolism of fatty acid signaling molecules termed epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	147-172	epoxide hydrolase 2, cytoplasmic	Mus musculus	43-46
26214067-1	2015	BACKGROUND: Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP) enzymes to vasoactive metabolites (mainly epoxyeicosatrienoic acids) which are known to play a protective role against damaging processes that may occur after re-oxygenation of the graft.	epoxyeicosatrienoic acids	116-141	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	52-67
26214067-1	2015	BACKGROUND: Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP) enzymes to vasoactive metabolites (mainly epoxyeicosatrienoic acids) which are known to play a protective role against damaging processes that may occur after re-oxygenation of the graft.	epoxyeicosatrienoic acids	116-141	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	69-72
26489615-0	2015	CYP2C8-derived epoxyeicosatrienoic acids decrease oxidative stress-induced endothelial apoptosis in development of atherosclerosis: Role of Nrf2 activation.	epoxyeicosatrienoic acids	15-40	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	0-6
26489615-0	2015	CYP2C8-derived epoxyeicosatrienoic acids decrease oxidative stress-induced endothelial apoptosis in development of atherosclerosis: Role of Nrf2 activation.	epoxyeicosatrienoic acids	15-40	NFE2 like bZIP transcription factor 2	Homo sapiens	140-144
26489615-1	2015	The aim of the present study is to investigate how cytochrome P450 enzymes (CYP) 2C8-derived epoxyeicosatrienoic acids (EETs) regulate the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and protect against oxidative stress-induced endothelial injuries in the development and progression of atherosclerosis.	epoxyeicosatrienoic acids	93-118	NFE2 like bZIP transcription factor 2	Homo sapiens	139-182
26489615-1	2015	The aim of the present study is to investigate how cytochrome P450 enzymes (CYP) 2C8-derived epoxyeicosatrienoic acids (EETs) regulate the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and protect against oxidative stress-induced endothelial injuries in the development and progression of atherosclerosis.	epoxyeicosatrienoic acids	93-118	NFE2 like bZIP transcription factor 2	Homo sapiens	184-188
26341485-1	2015	sEH (soluble epoxide hydrolase), which is encoded by the EPHX2 gene, regulates the actions of bioactive lipids, EETs (epoxyeicosatrienoic acids).	epoxyeicosatrienoic acids	118-143	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
26341485-1	2015	sEH (soluble epoxide hydrolase), which is encoded by the EPHX2 gene, regulates the actions of bioactive lipids, EETs (epoxyeicosatrienoic acids).	epoxyeicosatrienoic acids	118-143	epoxide hydrolase 2, cytoplasmic	Mus musculus	5-30
26341485-1	2015	sEH (soluble epoxide hydrolase), which is encoded by the EPHX2 gene, regulates the actions of bioactive lipids, EETs (epoxyeicosatrienoic acids).	epoxyeicosatrienoic acids	118-143	epoxide hydrolase 2, cytoplasmic	Mus musculus	57-62
26043075-1	2015	Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that is sensitive to cell swelling, arachidonic acid and its metabolites, epoxyeicosatrienoic acids, which are associated with cerebral ischemia.	epoxyeicosatrienoic acids	161-186	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	42-47
25626689-0	2015	Epoxyeicosatrienoic acids regulate macrophage polarization and prevent LPS-induced cardiac dysfunction.	epoxyeicosatrienoic acids	0-25	toll-like receptor 4	Mus musculus	71-74
26165641-3	2015	Epoxyeicosatrienoic acids (EETs) have an anti-inflammatory effect and are metabolized by soluble epoxide hydrolase (sEH: encoded by EPHX2 gene).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	89-114
26165641-3	2015	Epoxyeicosatrienoic acids (EETs) have an anti-inflammatory effect and are metabolized by soluble epoxide hydrolase (sEH: encoded by EPHX2 gene).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	116-119
26165641-3	2015	Epoxyeicosatrienoic acids (EETs) have an anti-inflammatory effect and are metabolized by soluble epoxide hydrolase (sEH: encoded by EPHX2 gene).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	132-137
25986738-1	2015	Soluble epoxide hydrolase (sEH) plays an essential role in chronic kidney disease by hydrolyzing renoprotective epoxyeicosatrienoic acids to the corresponding inactive dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	112-137	epoxide hydrolase 2	Rattus norvegicus	0-25
25986738-1	2015	Soluble epoxide hydrolase (sEH) plays an essential role in chronic kidney disease by hydrolyzing renoprotective epoxyeicosatrienoic acids to the corresponding inactive dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	112-137	epoxide hydrolase 2	Rattus norvegicus	27-30
25936480-2	2015	Cytochrome P-450 (CYP) is a variegated family of enzymes that, among many other activities, metabolize arachidonic acid to the vasoactive epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	138-163	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
25936480-2	2015	Cytochrome P-450 (CYP) is a variegated family of enzymes that, among many other activities, metabolize arachidonic acid to the vasoactive epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	138-163	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	18-21
26043075-1	2015	Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that is sensitive to cell swelling, arachidonic acid and its metabolites, epoxyeicosatrienoic acids, which are associated with cerebral ischemia.	epoxyeicosatrienoic acids	161-186	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	0-40
25951330-6	2015	Moreover, mesenteric bed and carotid were harvested to measure CYP2C23 and CYP2J2, the key isoenzymes in the formation of epoxyeicosatrienoic acids, and the soluble epoxide hydrolase, which is responsible for their degradation in the corresponding diols.	epoxyeicosatrienoic acids	122-147	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	75-81
26071213-1	2015	Roles of soluble epoxide hydrolase (sEH), the enzyme responsible for hydrolysis of epoxyeicosatrienoic acids (EETs) to their diols (DHETs), in the coronary circulation and cardiac function remain unknown.	epoxyeicosatrienoic acids	83-108	epoxide hydrolase 2, cytoplasmic	Mus musculus	9-34
26071213-1	2015	Roles of soluble epoxide hydrolase (sEH), the enzyme responsible for hydrolysis of epoxyeicosatrienoic acids (EETs) to their diols (DHETs), in the coronary circulation and cardiac function remain unknown.	epoxyeicosatrienoic acids	83-108	epoxide hydrolase 2, cytoplasmic	Mus musculus	36-39
25724490-1	2015	This study addressed the hypothesis that inhibiting the soluble epoxide hydrolase (sEH)-mediated degradation of epoxy-fatty acids, notably epoxyeicosatrienoic acids, has an additional impact against cardiovascular damage in insulin resistance, beyond its previously demonstrated beneficial effect on glucose homeostasis.	epoxyeicosatrienoic acids	139-164	epoxide hydrolase 2, cytoplasmic	Mus musculus	56-81
25724490-1	2015	This study addressed the hypothesis that inhibiting the soluble epoxide hydrolase (sEH)-mediated degradation of epoxy-fatty acids, notably epoxyeicosatrienoic acids, has an additional impact against cardiovascular damage in insulin resistance, beyond its previously demonstrated beneficial effect on glucose homeostasis.	epoxyeicosatrienoic acids	139-164	epoxide hydrolase 2, cytoplasmic	Mus musculus	83-86
25679385-0	2015	Overexpression of G-protein-coupled receptor 40 enhances the mitogenic response to epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	83-108	free fatty acid receptor 1	Homo sapiens	18-47
25467970-0	2015	Epoxyeicosatrienoic acids attenuate cigarette smoke extract-induced interleukin-8 production in bronchial epithelial cells.	epoxyeicosatrienoic acids	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	68-81
25733327-4	2015	The sEH is highly expressed in adipocytes, and it converts epoxyeicosatrienoic acids (EETs) into less bioactive dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	59-84	epoxide hydrolase 2, cytoplasmic	Mus musculus	4-7
25773261-0	2015	Erratum to: The protective effect of epoxyeicosatrienoic acids on cerebral ischemia/reperfusion injury is associated with PI3K/Akt pathway and ATP-sensitive potassium channels.	epoxyeicosatrienoic acids	37-62	AKT serine/threonine kinase 1	Homo sapiens	127-130
25511389-0	2015	Epoxyeicosatrienoic acids act through TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle membrane hyperpolarization and relaxation in human internal mammary arteries.	epoxyeicosatrienoic acids	0-25	transient receptor potential cation channel subfamily V member 4	Homo sapiens	38-43
25511389-0	2015	Epoxyeicosatrienoic acids act through TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle membrane hyperpolarization and relaxation in human internal mammary arteries.	epoxyeicosatrienoic acids	0-25	transient receptor potential cation channel subfamily C member 1	Homo sapiens	44-49
25511389-0	2015	Epoxyeicosatrienoic acids act through TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle membrane hyperpolarization and relaxation in human internal mammary arteries.	epoxyeicosatrienoic acids	0-25	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	50-56
25504503-2	2015	CYP2C enzymes have also been implicated in the metabolism of arachidonic acid to vasoactive epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	92-117	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-5
25560582-3	2015	CYP2C8, CYP2C9 and CYP2J2 gene involved in the metabolism of arachidonic acid, generates epoxyeicosatrienoic acids (EETs) that mediate dilation of coronary arteries improving post-ischemic cardiac contractile function, reduce vascular inflammation, and increase intravascular fibrinolysis.	epoxyeicosatrienoic acids	89-114	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	0-6
25560582-3	2015	CYP2C8, CYP2C9 and CYP2J2 gene involved in the metabolism of arachidonic acid, generates epoxyeicosatrienoic acids (EETs) that mediate dilation of coronary arteries improving post-ischemic cardiac contractile function, reduce vascular inflammation, and increase intravascular fibrinolysis.	epoxyeicosatrienoic acids	89-114	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	8-14
25560582-3	2015	CYP2C8, CYP2C9 and CYP2J2 gene involved in the metabolism of arachidonic acid, generates epoxyeicosatrienoic acids (EETs) that mediate dilation of coronary arteries improving post-ischemic cardiac contractile function, reduce vascular inflammation, and increase intravascular fibrinolysis.	epoxyeicosatrienoic acids	89-114	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	19-25
25377915-2	2015	Epoxyeicosatrienoic acids (EETs) are cytochrome P-450-dependent derivatives of arachidonic acid with antihypertensive, anti-inflammatory, and profibrinolytic functions.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	37-53
25642188-1	2014	Soluble epoxide hydrolase (sEH), a key enzyme in the metabolism of vasodilatory epoxyeicosatrienoic acids (EETs), is sexually dimorphic, suppressed by estrogen, and contributes to underlying sex differences in cerebral blood flow and injury after cerebral ischemia.	epoxyeicosatrienoic acids	80-105	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
25642188-1	2014	Soluble epoxide hydrolase (sEH), a key enzyme in the metabolism of vasodilatory epoxyeicosatrienoic acids (EETs), is sexually dimorphic, suppressed by estrogen, and contributes to underlying sex differences in cerebral blood flow and injury after cerebral ischemia.	epoxyeicosatrienoic acids	80-105	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
25277139-2	2014	CYP2J2 is the primary cytochrome P450 in the human heart and is most well known for the metabolism of AA to the biologically active epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	132-157	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
25870948-2	2015	The cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert an anti-inflammatory effect on the cardiovascular system.	epoxyeicosatrienoic acids	77-102	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	4-35
25870948-2	2015	The cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert an anti-inflammatory effect on the cardiovascular system.	epoxyeicosatrienoic acids	77-102	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	37-43
25427230-1	2015	PURPOSE OF REVIEW: Cytochrome (CYP) P450 metabolites of arachidonic acid, 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) contribute to the regulation of renal tubular and vascular function.	epoxyeicosatrienoic acids	120-145	peptidylprolyl isomerase G	Homo sapiens	31-34
25366463-0	2015	The protective effect of epoxyeicosatrienoic acids on cerebral ischemia/reperfusion injury is associated with PI3K/Akt pathway and ATP-sensitive potassium channels.	epoxyeicosatrienoic acids	25-50	AKT serine/threonine kinase 1	Rattus norvegicus	115-118
25677507-0	2015	Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway.	epoxyeicosatrienoic acids	12-37	heme oxygenase 1	Mus musculus	111-115
25677507-0	2015	Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway.	epoxyeicosatrienoic acids	12-37	wingless-type MMTV integration site family, member 1	Mus musculus	120-124
25677507-3	2015	Epoxyeicosatrienoic acids (EETs)-mediated up-regulation of heme oxygenase-1 (HO-1) protects against the detrimental consequences of MI in several animal models, however, the mechanism(s) by which this occurs remains unclear.	epoxyeicosatrienoic acids	0-25	heme oxygenase 1	Mus musculus	59-75
25677507-3	2015	Epoxyeicosatrienoic acids (EETs)-mediated up-regulation of heme oxygenase-1 (HO-1) protects against the detrimental consequences of MI in several animal models, however, the mechanism(s) by which this occurs remains unclear.	epoxyeicosatrienoic acids	0-25	heme oxygenase 1	Mus musculus	77-81
26632190-1	2015	Arachidonic acid (AA) is metabolized to epoxyeicosatrienoic acids (EETs) via cytochrome enzymes such as CYP 2C9, 2C8 and 2J2.	epoxyeicosatrienoic acids	40-65	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	104-111
25055826-4	2014	Cytochrome P450 epoxygenases (Cyp4x1 and Cyp2c11) are expressed in the brain and vasculature and metabolize arachidonic acid (AA) to form epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	138-163	cytochrome P450, family 4, subfamily x, polypeptide 1	Rattus norvegicus	30-36
25055826-4	2014	Cytochrome P450 epoxygenases (Cyp4x1 and Cyp2c11) are expressed in the brain and vasculature and metabolize arachidonic acid (AA) to form epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	138-163	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	41-48
25224811-7	2014	Acute BP-lowering effects of sEH inhibition in I3C-induced rats was associated with a marked increase in renal epoxyeicosatrienoic acids to dihydroxyeicosatrienoic acids ratio and acute natriuresis.	epoxyeicosatrienoic acids	111-136	epoxide hydrolase 2	Rattus norvegicus	29-32
25224811-9	2014	Our findings show that the acute BP-lowering effect of sEH inhibition in I3C-induced Cyp1a1-Ren-2 transgenic rats is mediated by a substantial increase in intrarenal epoxyeicosatrienoic acids and their natriuretic action without altering intrarenal renin-angiotensin system activity.	epoxyeicosatrienoic acids	166-191	epoxide hydrolase 2	Rattus norvegicus	55-58
25406731-1	2014	BACKGROUND: Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid by cytochrome P450 (CYP) and metabolized by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	12-37	epoxide hydrolase 2	Homo sapiens	123-148
25406731-1	2014	BACKGROUND: Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid by cytochrome P450 (CYP) and metabolized by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	12-37	epoxide hydrolase 2	Homo sapiens	150-153
25426071-1	2014	Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid through cytochrome P450 (CYP) epoxygenases have many biological functions.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	73-88
25426071-1	2014	Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid through cytochrome P450 (CYP) epoxygenases have many biological functions.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	90-93
25182955-1	2014	BACKGROUND: Cytochrome P450 (CYP) 2C9 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which have the crucial role in the modulation of cardiovascular homeostasis.	epoxyeicosatrienoic acids	135-160	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	12-37
24882266-2	2014	The main human CYP epoxygenases, i.e. CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	105-130	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	15-18
24882266-2	2014	The main human CYP epoxygenases, i.e. CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	105-130	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	38-44
24882266-2	2014	The main human CYP epoxygenases, i.e. CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	105-130	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	46-52
24882266-2	2014	The main human CYP epoxygenases, i.e. CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	105-130	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	54-61
24882266-2	2014	The main human CYP epoxygenases, i.e. CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	105-130	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	66-72
25310404-2	2014	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which have potent anti-inflammatory effects.	epoxyeicosatrienoic acids	86-111	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-15
25310404-2	2014	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which have potent anti-inflammatory effects.	epoxyeicosatrienoic acids	86-111	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	17-20
25151892-1	2014	Previous studies have indicated that cytochrome P450 (CYP) metabolites of arachidonic acid (AA), i.e., 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), play an important role in the regulation of renal tubular and vascular function.	epoxyeicosatrienoic acids	149-174	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	37-52
25151892-1	2014	Previous studies have indicated that cytochrome P450 (CYP) metabolites of arachidonic acid (AA), i.e., 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), play an important role in the regulation of renal tubular and vascular function.	epoxyeicosatrienoic acids	149-174	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	54-57
25173047-0	2014	Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans.	epoxyeicosatrienoic acids	31-56	insulin	Homo sapiens	77-84
25173047-1	2014	Epoxyeicosatrienoic acids (EETs) protect against the development of insulin resistance in rodents.	epoxyeicosatrienoic acids	0-25	insulin	Homo sapiens	68-75
24969701-6	2014	CYP2C11 produced epoxyeicosatrienoic acids (EETs) as 61.3%, and CYP2C6 produced midchain HETEs and EETs as 48.3 and 29.4%, respectively, of the total metabolites formed.	epoxyeicosatrienoic acids	17-42	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	0-7
24966089-1	2014	Cytochrome P-450, family 2, subfamily c, polypeptide 44 (Cyp2c44) epoxygenase metabolizes arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs) in kidney and vascular tissues.	epoxyeicosatrienoic acids	115-140	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	0-55
24966089-1	2014	Cytochrome P-450, family 2, subfamily c, polypeptide 44 (Cyp2c44) epoxygenase metabolizes arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs) in kidney and vascular tissues.	epoxyeicosatrienoic acids	115-140	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	57-64
24788058-1	2014	CYP2J2 enzyme is highly expressed in human tumors and carcinoma cell lines, and epoxyeicosatrienoic acids, CYP2J2-mediated metabolites, have been implicated in the pathologic development of human cancers.	epoxyeicosatrienoic acids	80-105	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
24788058-1	2014	CYP2J2 enzyme is highly expressed in human tumors and carcinoma cell lines, and epoxyeicosatrienoic acids, CYP2J2-mediated metabolites, have been implicated in the pathologic development of human cancers.	epoxyeicosatrienoic acids	80-105	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	107-113
25024195-1	2014	Prostaglandins derived from the cyclooxygenase (COX) pathway and epoxyeicosatrienoic acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH) pathway are important eicosanoids that regulate angiogenesis and tumorigenesis.	epoxyeicosatrienoic acids	65-90	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	107-148
25189712-1	2014	BACKGROUND: The cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) gene is expressed in the vascular endothelium, which metabolizes arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	212-237	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	16-69
25189712-1	2014	BACKGROUND: The cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) gene is expressed in the vascular endothelium, which metabolizes arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	212-237	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	71-77
25024195-1	2014	Prostaglandins derived from the cyclooxygenase (COX) pathway and epoxyeicosatrienoic acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH) pathway are important eicosanoids that regulate angiogenesis and tumorigenesis.	epoxyeicosatrienoic acids	65-90	epoxide hydrolase 2	Homo sapiens	150-153
24691274-2	2014	The omega-3 epoxide of DHA, 19, 20-EDP (epoxy docosapentaenoic acid), is metabolized by soluble epoxide hydrolase (sEH), which also metabolizes the anti-inflammatory and antihypertensive arachidonic acid epoxides, epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	214-239	epoxide hydrolase 2	Homo sapiens	88-113
24691274-2	2014	The omega-3 epoxide of DHA, 19, 20-EDP (epoxy docosapentaenoic acid), is metabolized by soluble epoxide hydrolase (sEH), which also metabolizes the anti-inflammatory and antihypertensive arachidonic acid epoxides, epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	214-239	epoxide hydrolase 2	Homo sapiens	115-118
24713619-0	2014	Epoxyeicosatrienoic acids attenuating hypotonic-induced apoptosis of IMCD cells via gamma-ENaC inhibition.	epoxyeicosatrienoic acids	0-25	sodium channel epithelial 1 subunit gamma	Homo sapiens	84-94
24917142-1	2014	PURPOSE: The purpose of this study was to investigate the role(s) of cytochrome P450 epoxygenases (CYPs) and their products, the epoxyeicosatrienoic acids (EETs), in hypoxia-induced VEGF production and pathologic retinal angiogenesis.	epoxyeicosatrienoic acids	129-154	vascular endothelial growth factor A	Homo sapiens	182-186
24510350-1	2014	Cytochrome P450 (CYP) 2C19 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which play a crucial role in either the detoxification or inactivation of potential carcinogens, or the bioactivation of some environmental procarcinogens to reactive DNA-binding metabolites.	epoxyeicosatrienoic acids	120-145	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-26
24824753-2	2014	sEH metabolizes neuroprotective epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	32-57	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
24285116-3	2014	In the present study, we explored the possible use of epoxyeicosatrienoic acids (EETs), epoxide metabolites of arachidonic acid, as therapeutic target against Abeta-induced mitochondrial impairment using cultured neonatal hippocampal astrocytes.	epoxyeicosatrienoic acids	54-79	amyloid beta precursor protein	Rattus norvegicus	159-164
24471737-2	2014	The aim of the present study was to test the hypothesis that increasing kidney tissue concentrations of epoxyeicosatrienoic acids (EETs) by preventing their degradation to the biologically inactive dihydroxyeicosatrienoic acids (DHETEs) using blockade of soluble epoxide hydrolase (sEH) would attenuate the progression of chronic kidney disease (CKD).	epoxyeicosatrienoic acids	104-129	epoxide hydrolase 2	Rattus norvegicus	255-280
24471737-2	2014	The aim of the present study was to test the hypothesis that increasing kidney tissue concentrations of epoxyeicosatrienoic acids (EETs) by preventing their degradation to the biologically inactive dihydroxyeicosatrienoic acids (DHETEs) using blockade of soluble epoxide hydrolase (sEH) would attenuate the progression of chronic kidney disease (CKD).	epoxyeicosatrienoic acids	104-129	epoxide hydrolase 2	Rattus norvegicus	282-285
24154693-2	2013	Similarly, renal cytochrome P-450 (CYP)-epoxygenase-derived arachidonic acid metabolites, epoxyeicosatrienoic acids (EETs), also are antihypertensive through inhibiting sodium reabsorption and vasodilation.	epoxyeicosatrienoic acids	90-115	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	17-33
24040964-0	2014	Influence of inflammation on cardiovascular protective effects of cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	102-127	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	66-81
24302581-3	2014	In this study, we show that targeting the formation of proangiogenic epoxyeicosatrienoic acids (EET) by the cytochrome P450 arachidonic acid epoxygenases (Cyp2c) represents a new and safe mechanism to treat NSCLC growth and progression.	epoxyeicosatrienoic acids	69-94	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	155-160
24903033-1	2014	BACKGROUND: Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acids to epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	86-111	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	12-43
24903033-1	2014	BACKGROUND: Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acids to epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	86-111	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	45-51
24154693-2	2013	Similarly, renal cytochrome P-450 (CYP)-epoxygenase-derived arachidonic acid metabolites, epoxyeicosatrienoic acids (EETs), also are antihypertensive through inhibiting sodium reabsorption and vasodilation.	epoxyeicosatrienoic acids	90-115	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	35-38
23474289-1	2013	Cytochrome p450 (CYP)2J2 is an epoxygenase enzyme that metabolises arachidonic acid to epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	87-112	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-24
24043255-1	2013	Soluble epoxide hydrolase (sEH) diminishes vasodilatory and neuroprotective effects of epoxyeicosatrienoic acids by hydrolyzing them to inactive dihydroxy metabolites.	epoxyeicosatrienoic acids	87-112	epoxide hydrolase 2	Rattus norvegicus	0-25
24043255-1	2013	Soluble epoxide hydrolase (sEH) diminishes vasodilatory and neuroprotective effects of epoxyeicosatrienoic acids by hydrolyzing them to inactive dihydroxy metabolites.	epoxyeicosatrienoic acids	87-112	epoxide hydrolase 2	Rattus norvegicus	27-30
24092818-1	2013	Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids into less active eicosanoids, and inhibitors of sEH have anti-inflammatory and antiapoptotic properties.	epoxyeicosatrienoic acids	60-85	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
24092818-1	2013	Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids into less active eicosanoids, and inhibitors of sEH have anti-inflammatory and antiapoptotic properties.	epoxyeicosatrienoic acids	60-85	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
24092818-1	2013	Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids into less active eicosanoids, and inhibitors of sEH have anti-inflammatory and antiapoptotic properties.	epoxyeicosatrienoic acids	60-85	epoxide hydrolase 2, cytoplasmic	Mus musculus	134-137
24092818-6	2013	Moreover, in pig kidney proximal tubule cells, cisplatin-induced mitochondrial trafficking of Bax and cytochrome c, caspase-3 activation, and oxidative stress are significantly attenuated in the presence of epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	207-232	apoptosis regulator BAX	Sus scrofa	94-97
24092818-6	2013	Moreover, in pig kidney proximal tubule cells, cisplatin-induced mitochondrial trafficking of Bax and cytochrome c, caspase-3 activation, and oxidative stress are significantly attenuated in the presence of epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	207-232	cytochrome c	Sus scrofa	102-114
24092818-6	2013	Moreover, in pig kidney proximal tubule cells, cisplatin-induced mitochondrial trafficking of Bax and cytochrome c, caspase-3 activation, and oxidative stress are significantly attenuated in the presence of epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	207-232	caspase 3	Sus scrofa	116-125
24324059-1	2013	Soluble epoxide hydrolase (sEH) hydrolyses/inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs) to their corresponding diols, and targeting sEH leads to strong anti-inflammatory effects.	epoxyeicosatrienoic acids	73-98	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
24324059-1	2013	Soluble epoxide hydrolase (sEH) hydrolyses/inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs) to their corresponding diols, and targeting sEH leads to strong anti-inflammatory effects.	epoxyeicosatrienoic acids	73-98	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
24324059-1	2013	Soluble epoxide hydrolase (sEH) hydrolyses/inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs) to their corresponding diols, and targeting sEH leads to strong anti-inflammatory effects.	epoxyeicosatrienoic acids	73-98	epoxide hydrolase 2, cytoplasmic	Mus musculus	150-153
22517541-1	2013	Soluble epoxide hydrolase (sEH) quickly inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs) by converting them to dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	70-95	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
24096258-2	2013	Cytochrome P450 (CYP450) eicosanoids derived from arachidonic acid include vasodilator epoxyeicosatrienoic acids (EETs) and the vasoconstrictor 20-hydroxyeicosatrienoic acid (20-HETE).	epoxyeicosatrienoic acids	87-112	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
24096258-2	2013	Cytochrome P450 (CYP450) eicosanoids derived from arachidonic acid include vasodilator epoxyeicosatrienoic acids (EETs) and the vasoconstrictor 20-hydroxyeicosatrienoic acid (20-HETE).	epoxyeicosatrienoic acids	87-112	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-23
23787000-10	2013	Cav-1(-/-) endothelium is deficient in shear stress-mediated generation of vasodilators including NO, prostaglandins, and epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	122-147	caveolin 1, caveolae protein	Mus musculus	0-5
23611540-1	2013	We have shown previously that inhibition of sEH (soluble epoxide hydrolase) increased EETs (epoxyeicosatrienoic acids) levels and reduced renal injury in diabetic mice and these changes were associated with induction of HO (haem oxygenase)-1.	epoxyeicosatrienoic acids	92-117	epoxide hydrolase 2, cytoplasmic	Mus musculus	44-47
23611540-1	2013	We have shown previously that inhibition of sEH (soluble epoxide hydrolase) increased EETs (epoxyeicosatrienoic acids) levels and reduced renal injury in diabetic mice and these changes were associated with induction of HO (haem oxygenase)-1.	epoxyeicosatrienoic acids	92-117	epoxide hydrolase 2, cytoplasmic	Mus musculus	49-74
23899929-3	2013	Soluble epoxide hydrolase (sEH) is a potential mediator of injury via its metabolism of neuroprotective epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	104-129	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
23899929-3	2013	Soluble epoxide hydrolase (sEH) is a potential mediator of injury via its metabolism of neuroprotective epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	104-129	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
23701967-2	2013	sEH readily hydrolyzes lipid signaling molecules, including the epoxyeicosatrienoic acids (EETs), epoxidized lipids produced from arachidonic acid by the action of cytochrome p450s.	epoxyeicosatrienoic acids	64-89	epoxide hydrolase 2	Homo sapiens	0-3
23729620-1	2013	Bradykinin causes vascular relaxations through release of endothelial relaxing factors including prostacyclin, nitric oxide (NO) and epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	133-158	kininogen 1	Bos taurus	0-10
24113215-1	2013	Cytochrome P450 2C19 (CYP2C19) is expressed in human endothelial cells and catalyzes the biosynthesis of vasoprotective epoxyeicosatrienoic acids and 19-hydroxyeicosatetraenoic acid from arachidonic acid.	epoxyeicosatrienoic acids	120-145	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-20
24113215-1	2013	Cytochrome P450 2C19 (CYP2C19) is expressed in human endothelial cells and catalyzes the biosynthesis of vasoprotective epoxyeicosatrienoic acids and 19-hydroxyeicosatetraenoic acid from arachidonic acid.	epoxyeicosatrienoic acids	120-145	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	22-29
22517541-1	2013	Soluble epoxide hydrolase (sEH) quickly inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs) by converting them to dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	70-95	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
23792539-1	2013	Accumulating evidence suggests that soluble epoxide hydrolase (sEH) plays a key role in controlling levels of lipid signaling molecules, and that the potent sEH inhibitors may be potential therapeutic drugs for a number of diseases associated with metabolism of epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	262-287	epoxide hydrolase 2, cytoplasmic	Mus musculus	36-61
23792539-1	2013	Accumulating evidence suggests that soluble epoxide hydrolase (sEH) plays a key role in controlling levels of lipid signaling molecules, and that the potent sEH inhibitors may be potential therapeutic drugs for a number of diseases associated with metabolism of epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	262-287	epoxide hydrolase 2, cytoplasmic	Mus musculus	63-66
23792539-1	2013	Accumulating evidence suggests that soluble epoxide hydrolase (sEH) plays a key role in controlling levels of lipid signaling molecules, and that the potent sEH inhibitors may be potential therapeutic drugs for a number of diseases associated with metabolism of epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	262-287	epoxide hydrolase 2, cytoplasmic	Mus musculus	157-160
22525341-1	2013	BACKGROUND: Epoxyeicosatrienoic acids (EETs) are natural angiogenic mediators regulated by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	12-37	epoxide hydrolase 2	Homo sapiens	118-121
23766516-7	2013	With Acsl4 knockdown, incubation with 17 mm glucose increased media epoxyeicosatrienoic acids (EETs) and reduced cell membrane levels of EETs.	epoxyeicosatrienoic acids	68-93	acyl-CoA synthetase long-chain family member 4	Rattus norvegicus	5-10
23684773-1	2013	BACKGROUND: Cytochrome P450 (CYP) 2J2 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	135-160	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	12-37
23967089-3	2013	Epoxyeicosatrienoic acids (EETs) are anti-inflammatory molecules synthesized by various cytochrome P450 (Cyp) enzymes from arachidonic acid.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	88-103
23967089-3	2013	Epoxyeicosatrienoic acids (EETs) are anti-inflammatory molecules synthesized by various cytochrome P450 (Cyp) enzymes from arachidonic acid.	epoxyeicosatrienoic acids	0-25	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	105-108
23000418-1	2013	Cyclooxygenase (COX)-derived prostaglandins and cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids are important regulators of inflammation; however, functional interactions between these pathways in the regulation of vascular inflammation in vivo have not been studied.	epoxyeicosatrienoic acids	90-115	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	48-63
23000418-1	2013	Cyclooxygenase (COX)-derived prostaglandins and cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids are important regulators of inflammation; however, functional interactions between these pathways in the regulation of vascular inflammation in vivo have not been studied.	epoxyeicosatrienoic acids	90-115	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	65-68
23434473-1	2013	Soluble epoxide hydrolase (sEH, EPHX2) metabolizes eicosanoid epoxides, including epoxyeicosatrienoic acids (EETs) to the corresponding dihydroxyeicosatrienoic acids (DHETs), and leukotoxin (LTX) to leukotoxin diol (LTX diol).	epoxyeicosatrienoic acids	82-107	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
23434473-1	2013	Soluble epoxide hydrolase (sEH, EPHX2) metabolizes eicosanoid epoxides, including epoxyeicosatrienoic acids (EETs) to the corresponding dihydroxyeicosatrienoic acids (DHETs), and leukotoxin (LTX) to leukotoxin diol (LTX diol).	epoxyeicosatrienoic acids	82-107	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
23434473-1	2013	Soluble epoxide hydrolase (sEH, EPHX2) metabolizes eicosanoid epoxides, including epoxyeicosatrienoic acids (EETs) to the corresponding dihydroxyeicosatrienoic acids (DHETs), and leukotoxin (LTX) to leukotoxin diol (LTX diol).	epoxyeicosatrienoic acids	82-107	epoxide hydrolase 2, cytoplasmic	Mus musculus	32-37
23647230-2	2013	In cardiac tissues, CYP2J2 can adopt arachidonic acid as a major substrate to produce epoxyeicosatrienoic acids (EETs), which can protect endothelial cells from ischemic or hypoxic injuries and have been implicated in the pathogenesis of coronary artery disease and hypertension.	epoxyeicosatrienoic acids	86-111	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	20-26
22922020-1	2013	Cardioprotective effects of epoxyeicosatrienoic acids (EETs) have been demonstrated in models of young mice with either the cardiomyocyte specific over-expression of cytochrome P450 2J2 (CYP2J2 Tr) or deletion of soluble epoxide hydrolase (sEH null).	epoxyeicosatrienoic acids	28-53	epoxide hydrolase 2, cytoplasmic	Mus musculus	213-238
22922020-1	2013	Cardioprotective effects of epoxyeicosatrienoic acids (EETs) have been demonstrated in models of young mice with either the cardiomyocyte specific over-expression of cytochrome P450 2J2 (CYP2J2 Tr) or deletion of soluble epoxide hydrolase (sEH null).	epoxyeicosatrienoic acids	28-53	epoxide hydrolase 2, cytoplasmic	Mus musculus	240-243
24216999-2	2013	Cytochrome P450 (CYP) activity and synthesis of both epoxyeicosatrienoic acids (EETs) and 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), together with vascular endothelial growth factor (VEGF) and heme oxygenase system (HO) have emerged as important modulators of tumor growth and metastasis.	epoxyeicosatrienoic acids	53-78	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
24216999-2	2013	Cytochrome P450 (CYP) activity and synthesis of both epoxyeicosatrienoic acids (EETs) and 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), together with vascular endothelial growth factor (VEGF) and heme oxygenase system (HO) have emerged as important modulators of tumor growth and metastasis.	epoxyeicosatrienoic acids	53-78	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
23122666-1	2013	BACKGROUND: Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess angiogenic effects.	epoxyeicosatrienoic acids	42-67	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	12-27
23122666-1	2013	BACKGROUND: Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess angiogenic effects.	epoxyeicosatrienoic acids	42-67	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	29-32
23725831-1	2013	AIM: To investigate the relationship between cerebroprotection of pinocembrin and epoxyeicosatrienoic acids (EETs) and their regulating enzyme soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	82-107	epoxide hydrolase 2	Rattus norvegicus	143-168
23725831-1	2013	AIM: To investigate the relationship between cerebroprotection of pinocembrin and epoxyeicosatrienoic acids (EETs) and their regulating enzyme soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	82-107	epoxide hydrolase 2	Rattus norvegicus	170-173
23232840-1	2013	Epoxyeicosatrienoic acids, substrates for soluble epoxide hydrolase (sEH), exhibit vasodilatory and antihypertrophic activities.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	42-67
23039246-1	2013	The aim of the present study was to evaluate the hypothesis that the antihypertensive effects of inhibition of soluble epoxide hydrolase (sEH) are mediated by increased intrarenal availability of epoxyeicosatrienoic acids (EETs), with consequent improvement in renal haemodynamic autoregulatory efficiency and the pressure-natriuresis relationship.	epoxyeicosatrienoic acids	196-221	epoxide hydrolase 2	Rattus norvegicus	111-136
23039246-1	2013	The aim of the present study was to evaluate the hypothesis that the antihypertensive effects of inhibition of soluble epoxide hydrolase (sEH) are mediated by increased intrarenal availability of epoxyeicosatrienoic acids (EETs), with consequent improvement in renal haemodynamic autoregulatory efficiency and the pressure-natriuresis relationship.	epoxyeicosatrienoic acids	196-221	epoxide hydrolase 2	Rattus norvegicus	138-141
23619744-8	2013	Surprisingly, the CYP metabolites of AA, epoxyeicosatrienoic acids (EETs), were much less potent activators of TRPV4, and CYP inhibitors did not affect EET production in HCAECs.	epoxyeicosatrienoic acids	41-66	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	18-21
23585883-1	2013	Soluble Epoxide Hydrolase (sEH) is a key enzyme in the metabolism and termination of action of epoxyeicosatrienoic acids, derivatives of arachidonic acid, which are protective against ischemic stroke.	epoxyeicosatrienoic acids	95-120	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
23585883-1	2013	Soluble Epoxide Hydrolase (sEH) is a key enzyme in the metabolism and termination of action of epoxyeicosatrienoic acids, derivatives of arachidonic acid, which are protective against ischemic stroke.	epoxyeicosatrienoic acids	95-120	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
23232840-1	2013	Epoxyeicosatrienoic acids, substrates for soluble epoxide hydrolase (sEH), exhibit vasodilatory and antihypertrophic activities.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	69-72
22641086-4	2012	sEH contributes to neuronal cell death by inactivating neuroprotective epoxyeicosatrienoic acids (EETs).	epoxyeicosatrienoic acids	71-96	epoxide hydrolase 2	Homo sapiens	0-3
23403888-0	2013	Effect of ischemia reperfusion injury and epoxyeicosatrienoic acids on caveolin expression in mouse myocardium.	epoxyeicosatrienoic acids	42-67	caveolin 1, caveolae protein	Mus musculus	71-79
23152298-1	2013	Epoxyeicosatrienoic acids, hydrolyzed by soluble epoxide hydrolase (sEH), have multiple biological functions, including the regulation of vascular tone, renal tubular transport, and being anti-inflammatory.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	41-66
23152298-1	2013	Epoxyeicosatrienoic acids, hydrolyzed by soluble epoxide hydrolase (sEH), have multiple biological functions, including the regulation of vascular tone, renal tubular transport, and being anti-inflammatory.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	68-71
23237835-2	2013	The inhibition of soluble epoxide hydrolase leads to elevated levels of epoxyeicosatrienoic acids (EETs), and thus inhibitors of sEH represent one of a novel approach to the development of vasodilatory and anti-inflammatory drugs.	epoxyeicosatrienoic acids	72-97	epoxide hydrolase 2	Homo sapiens	18-43
23237835-2	2013	The inhibition of soluble epoxide hydrolase leads to elevated levels of epoxyeicosatrienoic acids (EETs), and thus inhibitors of sEH represent one of a novel approach to the development of vasodilatory and anti-inflammatory drugs.	epoxyeicosatrienoic acids	72-97	epoxide hydrolase 2	Homo sapiens	129-132
23020295-1	2013	The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by soluble epoxide hydrolase (sEH) to 1,2-diols were first reported 30 years ago.	epoxyeicosatrienoic acids	16-41	epoxide hydrolase 2	Homo sapiens	84-109
23020295-1	2013	The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by soluble epoxide hydrolase (sEH) to 1,2-diols were first reported 30 years ago.	epoxyeicosatrienoic acids	16-41	epoxide hydrolase 2	Homo sapiens	111-114
22588244-1	2012	BACKGROUND: Soluble epoxide hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids (EETs) into their much less active dihydroxy derivatives dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	74-99	epoxide hydrolase 2, cytoplasmic	Mus musculus	12-37
22588244-1	2012	BACKGROUND: Soluble epoxide hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids (EETs) into their much less active dihydroxy derivatives dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	74-99	epoxide hydrolase 2, cytoplasmic	Mus musculus	39-42
23283969-0	2013	Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation.	epoxyeicosatrienoic acids	0-25	mitogen-activated protein kinase 1	Homo sapiens	80-121
23283969-0	2013	Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation.	epoxyeicosatrienoic acids	0-25	mitogen-activated protein kinase 3	Homo sapiens	123-129
23107877-2	2013	TRPV4 channels are expressed in both endothelium and vascular smooth muscle cells and can be activated by numerous stimuli including mechanical (eg, shear stress, cell swelling, and heat) and chemical (eg, epoxyeicosatrienoic acids, endocannabinoids, and 4alpha-phorbol esters).	epoxyeicosatrienoic acids	206-231	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
21912424-1	2013	The omega-hydroxylase CYP4A11 catalyzes the transformation of epoxyeicosatrienoic acids (EETs) to omega-hydroxylated EETs, endogenous peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists.	epoxyeicosatrienoic acids	62-87	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	22-29
21912424-1	2013	The omega-hydroxylase CYP4A11 catalyzes the transformation of epoxyeicosatrienoic acids (EETs) to omega-hydroxylated EETs, endogenous peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists.	epoxyeicosatrienoic acids	62-87	peroxisome proliferator activated receptor alpha	Homo sapiens	134-182
21912424-1	2013	The omega-hydroxylase CYP4A11 catalyzes the transformation of epoxyeicosatrienoic acids (EETs) to omega-hydroxylated EETs, endogenous peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists.	epoxyeicosatrienoic acids	62-87	peroxisome proliferator activated receptor alpha	Homo sapiens	184-193
23688134-11	2013	CYP2J2 and its role in the metabolism of arachidonic acid to epoxyeicosatrienoic acids and angiogenesis will also be examined.	epoxyeicosatrienoic acids	61-86	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
22865388-2	2012	Recent data have shown that pharmacological inhibition of soluble epoxide hydrolase (sEH), an enzyme that decreases the endogenous levels of protective epoxyeicosatrienoic acids (EETs), improves glucose homeostasis in insulin-resistant mice.	epoxyeicosatrienoic acids	152-177	epoxide hydrolase 2, cytoplasmic	Mus musculus	58-83
22865388-2	2012	Recent data have shown that pharmacological inhibition of soluble epoxide hydrolase (sEH), an enzyme that decreases the endogenous levels of protective epoxyeicosatrienoic acids (EETs), improves glucose homeostasis in insulin-resistant mice.	epoxyeicosatrienoic acids	152-177	epoxide hydrolase 2, cytoplasmic	Mus musculus	85-88
22307673-1	2012	A significant endothelium-dependent vasodilation persists after inhibition of nitric oxide synthase (NOS) and cyclooxygenase (COX) in the coronary vasculature, which has been linked to the activation of cytochrome P-450 (CYP) epoxygenases expressed in endothelial cells and subsequent generation of vasodilator epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	311-336	nitric oxide synthase 2	Sus scrofa	78-99
22621785-3	2012	Epoxyeicosatrienoic acids (EETs), products of cytochrome P-450 epoxidation of arachidonic acid, have vasculoprotective and anti-inflammatory effects including inhibition of platelet activation, cell migration, and adhesion.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	46-62
22624559-1	2012	Epoxyeicosatrienoic acids (EETs) are active metabolites of arachidonic acid that are inactivated by soluble epoxide hydrolase enzyme (sEH) to dihydroxyeicosatrienoic acid.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	100-132
22624559-1	2012	Epoxyeicosatrienoic acids (EETs) are active metabolites of arachidonic acid that are inactivated by soluble epoxide hydrolase enzyme (sEH) to dihydroxyeicosatrienoic acid.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	134-137
22414856-2	2012	Epoxyeicosatrienoic acids (EETs) are anti-inflammatory cytochrome P450-derived eicosanoids that are abundantly produced in the kidney and metabolized by soluble epoxide hydrolase (sEH; Ephx2) to less active dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	153-178
22414856-2	2012	Epoxyeicosatrienoic acids (EETs) are anti-inflammatory cytochrome P450-derived eicosanoids that are abundantly produced in the kidney and metabolized by soluble epoxide hydrolase (sEH; Ephx2) to less active dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	180-183
22414856-2	2012	Epoxyeicosatrienoic acids (EETs) are anti-inflammatory cytochrome P450-derived eicosanoids that are abundantly produced in the kidney and metabolized by soluble epoxide hydrolase (sEH; Ephx2) to less active dihydroxyeicosatrienoic acids.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2, cytoplasmic	Mus musculus	185-190
22173545-2	2012	Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as candidate mediators in the development of hypertension in several animal models, with remarkable sex-specific effect.	epoxyeicosatrienoic acids	70-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
22173545-2	2012	Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as candidate mediators in the development of hypertension in several animal models, with remarkable sex-specific effect.	epoxyeicosatrienoic acids	70-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
22260463-1	2012	The cytochrome P450 epoxygenase, CYP2J2, converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs), which are highly abundant in the kidney and considered renoprotective.	epoxyeicosatrienoic acids	89-114	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	33-39
22354938-2	2012	Soluble epoxide hydrolase (sEH) is a major enzyme that hydrolyzes epoxyeicosatrienoic acids and attenuates their cardiovascular protective effects.	epoxyeicosatrienoic acids	66-91	epoxide hydrolase 2	Homo sapiens	0-25
22354938-2	2012	Soluble epoxide hydrolase (sEH) is a major enzyme that hydrolyzes epoxyeicosatrienoic acids and attenuates their cardiovascular protective effects.	epoxyeicosatrienoic acids	66-91	epoxide hydrolase 2	Homo sapiens	27-30
22412088-0	2012	Epoxyeicosatrienoic acids contribute with altered nitric oxide and endothelin-1 pathways to conduit artery endothelial dysfunction in essential hypertension.	epoxyeicosatrienoic acids	0-25	endothelin 1	Homo sapiens	67-79
22313298-2	2011	Inhibition of sEH by a highly selective and potent sEH inhibitor (sEHI) elevates the epoxyeicosatrienoic acids (EETs) level in vivo leading to decreased inflammation.	epoxyeicosatrienoic acids	85-110	epoxide hydrolase 2	Homo sapiens	14-17
22155000-1	2012	Epoxyeicosatrienoic acids (EETs), cytochrome P450-derived metabolites of arachidonic acid, are endogenously produced epoxides that act as substrates for the soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	157-182
22155000-1	2012	Epoxyeicosatrienoic acids (EETs), cytochrome P450-derived metabolites of arachidonic acid, are endogenously produced epoxides that act as substrates for the soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	184-187
22071359-1	2012	BACKGROUND: Cytochrome P450 (CYP)2C19 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids, which play a key role in regulating vascular tone.	epoxyeicosatrienoic acids	131-156	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	12-37
22072631-2	2012	The role of sEH hydrolase activity in the metabolism of epoxyeicosatrienoic acids (EETs) and the activation of endothelial nitric oxide synthase (eNOS) in endothelial cells (ECs) has been well defined.	epoxyeicosatrienoic acids	56-81	epoxide hydrolase 2, cytoplasmic	Mus musculus	12-15
22415079-0	2012	Heme oxygenase (HO-1) rescue of adipocyte dysfunction in HO-2 deficient mice via recruitment of epoxyeicosatrienoic acids (EETs) and adiponectin.	epoxyeicosatrienoic acids	96-121	heme oxygenase 1	Mus musculus	16-20
22720061-2	2012	Soluble epoxide hydrolase (sEH) is a major enzyme hydrolyzing epoxyeicosatrienoic acids and attenuates their cardiovascular protective and anti-inflammatory effects.	epoxyeicosatrienoic acids	62-87	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
22720061-2	2012	Soluble epoxide hydrolase (sEH) is a major enzyme hydrolyzing epoxyeicosatrienoic acids and attenuates their cardiovascular protective and anti-inflammatory effects.	epoxyeicosatrienoic acids	62-87	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
22590647-1	2012	Soluble epoxide hydrolase (sEH) in endothelial cells determines the plasma concentrations of epoxyeicosatrienoic acids (EETs), which may act as vasoactive agents to control vascular tone.	epoxyeicosatrienoic acids	93-118	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
22590647-1	2012	Soluble epoxide hydrolase (sEH) in endothelial cells determines the plasma concentrations of epoxyeicosatrienoic acids (EETs), which may act as vasoactive agents to control vascular tone.	epoxyeicosatrienoic acids	93-118	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
21887579-0	2011	Cytochrome P450-derived epoxyeicosatrienoic acids accelerate wound epithelialization and neovascularization in the hairless mouse ear wound model.	epoxyeicosatrienoic acids	24-49	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-15
21996372-2	2011	TRPV4 is also thermosensitive and responds to moderate heat (from 24 to 27  C) as well as to phorbol esters (4alpha-PDD) and several endogenous substances including arachidonic acid (AA), the endocannabinoids anandamide and 2-AG, and cytochrome P-450 metabolites of AA, such as epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	278-303	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
22155238-1	2012	The study addressed the hypothesis that soluble epoxide hydrolase (sEH) inhibition, which increases cardiovascular protective epoxyeicosatrienoic acids (EETs), exerts beneficial effects in an established chronic heart failure (CHF) model.	epoxyeicosatrienoic acids	126-151	epoxide hydrolase 2	Rattus norvegicus	40-65
22155238-1	2012	The study addressed the hypothesis that soluble epoxide hydrolase (sEH) inhibition, which increases cardiovascular protective epoxyeicosatrienoic acids (EETs), exerts beneficial effects in an established chronic heart failure (CHF) model.	epoxyeicosatrienoic acids	126-151	epoxide hydrolase 2	Rattus norvegicus	67-70
22975950-1	2012	Epoxyeicosatrienoic acids (EETs) produced by cytochrome P450 (CYP)-dependent epoxidation of arachidonic acid (AA) inhibit thrombocyte adhesion to the vascular wall.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	45-60
22975950-1	2012	Epoxyeicosatrienoic acids (EETs) produced by cytochrome P450 (CYP)-dependent epoxidation of arachidonic acid (AA) inhibit thrombocyte adhesion to the vascular wall.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	62-65
22848834-1	2012	Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-118
22848834-1	2012	Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	120-123
22848834-1	2012	Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	180-205
22848834-1	2012	Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs).	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Homo sapiens	207-210
23106500-1	2012	Epoxyeicosatrienoic acids (EETs) and their regulating enzyme soluble epoxide hydrolase (sEH) have been associated with ischemic stroke.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	61-86
23106500-1	2012	Epoxyeicosatrienoic acids (EETs) and their regulating enzyme soluble epoxide hydrolase (sEH) have been associated with ischemic stroke.	epoxyeicosatrienoic acids	0-25	epoxide hydrolase 2	Rattus norvegicus	88-91
22182836-1	2012	Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	68-83
22182836-1	2012	Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases.	epoxyeicosatrienoic acids	0-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	85-88
22189162-1	2011	Accumulating evidence suggests that cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs) which play important roles in various pathophysiological processes.	epoxyeicosatrienoic acids	104-129	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	36-51
22189162-1	2011	Accumulating evidence suggests that cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs) which play important roles in various pathophysiological processes.	epoxyeicosatrienoic acids	104-129	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	53-56
22180071-1	2011	Cytochrome P450 (CYP) 2C19 metabolizes arachidonic  acid to biologically active epoxyeicosatrienoic acids, which significantly  promote proliferation of cancer cells in vitro and in vivo.	epoxyeicosatrienoic acids	80-105	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-26
22183943-1	2011	Cytochrome P450  (CYP) 2C19 metabolizes arachidonic acid to biologically active  epoxyeicosatrienoic acids, which strongly promote proliferation of cancer cells in vitro and in vivo.	epoxyeicosatrienoic acids	81-106	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-27
22313298-2	2011	Inhibition of sEH by a highly selective and potent sEH inhibitor (sEHI) elevates the epoxyeicosatrienoic acids (EETs) level in vivo leading to decreased inflammation.	epoxyeicosatrienoic acids	85-110	epoxide hydrolase 2	Homo sapiens	51-54
21753077-1	2011	Cytochrome P-450 metabolites of arachidonic acid, the epoxyeicosatrienoic acids (EETs) and hydrogen peroxide (H(2)O(2)), are important signaling molecules in the kidney.	epoxyeicosatrienoic acids	54-79	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
21757024-6	2011	A recent publication has demonstrated that stabilizing the levels of epoxyeicosatrienoic acids (EETs), CYP eicosanoids, by inhibiting or deleting soluble epoxide hydrolase (sEH) improves beta-cell function and reduces beta-cell apoptosis in diabetes.	epoxyeicosatrienoic acids	69-94	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-106
21062421-4	2011	In endothelial cells, TRPV1 is activated by endocannabinoids, TRPV3 by dietary agonists and TRPV4 by shear stress, epoxyeicosatrienoic acids (EETs) and downstream of Gq-coupled receptor activation.	epoxyeicosatrienoic acids	115-140	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-27
21062421-4	2011	In endothelial cells, TRPV1 is activated by endocannabinoids, TRPV3 by dietary agonists and TRPV4 by shear stress, epoxyeicosatrienoic acids (EETs) and downstream of Gq-coupled receptor activation.	epoxyeicosatrienoic acids	115-140	transient receptor potential cation channel subfamily V member 4	Homo sapiens	92-97
21642892-1	2011	OBJECTIVE: Common polymorphisms within cytochrome P450 2J2 (CYP2J2) and epoxide hydrolase 2 (EPHX2), which are involved in the generation or hydrolysis of epoxyeicosatrienoic acids, may determine susceptibility to the development of cardiovascular disease.	epoxyeicosatrienoic acids	155-180	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	39-58
21642892-1	2011	OBJECTIVE: Common polymorphisms within cytochrome P450 2J2 (CYP2J2) and epoxide hydrolase 2 (EPHX2), which are involved in the generation or hydrolysis of epoxyeicosatrienoic acids, may determine susceptibility to the development of cardiovascular disease.	epoxyeicosatrienoic acids	155-180	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	60-66
21642892-1	2011	OBJECTIVE: Common polymorphisms within cytochrome P450 2J2 (CYP2J2) and epoxide hydrolase 2 (EPHX2), which are involved in the generation or hydrolysis of epoxyeicosatrienoic acids, may determine susceptibility to the development of cardiovascular disease.	epoxyeicosatrienoic acids	155-180	epoxide hydrolase 2	Homo sapiens	72-91
21642892-1	2011	OBJECTIVE: Common polymorphisms within cytochrome P450 2J2 (CYP2J2) and epoxide hydrolase 2 (EPHX2), which are involved in the generation or hydrolysis of epoxyeicosatrienoic acids, may determine susceptibility to the development of cardiovascular disease.	epoxyeicosatrienoic acids	155-180	epoxide hydrolase 2	Homo sapiens	93-98
21519968-1	2011	INTRODUCTION: Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs), which in turn are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	74-99	epoxide hydrolase 2	Homo sapiens	180-205
21519968-1	2011	INTRODUCTION: Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs), which in turn are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	74-99	epoxide hydrolase 2	Homo sapiens	207-210
21697548-1	2011	Cytochrome P450 (CYP) epoxygenases CYP2C8 and CYP2J2 generate epoxyeicosatrienoic acids (EETs) from arachidonic acid.	epoxyeicosatrienoic acids	62-87	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	35-41
21683067-2	2011	Epoxyeicosatrienoic acids (EETs) are cytochrome P-450 metabolites of arachidonic acid reported to have multiple biological functions, including blocking of leukocyte recruitment to inflamed endothelium in cell culture through reduction of adhesion molecule expression.	epoxyeicosatrienoic acids	0-25	uncharacterized protein LOC107819388	Nicotiana tabacum	37-53
21476972-6	2011	CYP isoforms expressed in the heart are critical for generation of epoxyeicosatrienoic acids (EETs) and ROS.	epoxyeicosatrienoic acids	67-92	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
21757024-6	2011	A recent publication has demonstrated that stabilizing the levels of epoxyeicosatrienoic acids (EETs), CYP eicosanoids, by inhibiting or deleting soluble epoxide hydrolase (sEH) improves beta-cell function and reduces beta-cell apoptosis in diabetes.	epoxyeicosatrienoic acids	69-94	epoxide hydrolase 2	Homo sapiens	146-171
21757024-6	2011	A recent publication has demonstrated that stabilizing the levels of epoxyeicosatrienoic acids (EETs), CYP eicosanoids, by inhibiting or deleting soluble epoxide hydrolase (sEH) improves beta-cell function and reduces beta-cell apoptosis in diabetes.	epoxyeicosatrienoic acids	69-94	epoxide hydrolase 2	Homo sapiens	173-176
21411763-2	2011	A previous study indicated that bioavailability of cytochrome P-450 metabolites epoxyeicosatrienoic acids (EETs) is decreased while that of 20-hydroxyeicosatetraenoic acids (20-HETE) is increased in this model.	epoxyeicosatrienoic acids	80-105	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	51-67
21332417-1	2011	OBJECTIVES: Cytochrome P450 (CYP) 2C19 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which play a centralrole in regulating renal tubular fluid-electrolyte transport and vascular tone.	epoxyeicosatrienoic acids	132-157	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	12-38
21155804-1	2011	It has recently been reported that soluble epoxide hydrolase (sEH), the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), is expressed in axons of cortical neurons; however, the functional relevance of axonal sEH localization is unknown.	epoxyeicosatrienoic acids	102-127	epoxide hydrolase 2	Homo sapiens	35-60
21451419-1	2011	OBJECTIVES: The study addresses the hypothesis that endothelial dysfunction in experimental arterial hypertension can be related to an alteration in epoxyeicosatrienoic acids (EETs) pathway and can be prevented by the inhibition of EETs degradation by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	149-174	epoxide hydrolase 2, cytoplasmic	Mus musculus	252-277
21451419-1	2011	OBJECTIVES: The study addresses the hypothesis that endothelial dysfunction in experimental arterial hypertension can be related to an alteration in epoxyeicosatrienoic acids (EETs) pathway and can be prevented by the inhibition of EETs degradation by soluble epoxide hydrolase (sEH).	epoxyeicosatrienoic acids	149-174	epoxide hydrolase 2, cytoplasmic	Mus musculus	279-282
21155804-1	2011	It has recently been reported that soluble epoxide hydrolase (sEH), the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), is expressed in axons of cortical neurons; however, the functional relevance of axonal sEH localization is unknown.	epoxyeicosatrienoic acids	102-127	epoxide hydrolase 2	Homo sapiens	62-65
21266668-1	2011	We hypothesized that perinatal inhibition of soluble epoxide hydrolase (SEH), which metabolizes epoxyeicosatrienoic acids in the arachidonic acid (AA) cascade, with an orally active SEH inhibitor, 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), would persistently reduce blood pressure (BP) in adult SHR despite discontinuation of AUDA at 4 wk of age.	epoxyeicosatrienoic acids	96-121	epoxide hydrolase 2	Rattus norvegicus	45-70
21266668-1	2011	We hypothesized that perinatal inhibition of soluble epoxide hydrolase (SEH), which metabolizes epoxyeicosatrienoic acids in the arachidonic acid (AA) cascade, with an orally active SEH inhibitor, 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), would persistently reduce blood pressure (BP) in adult SHR despite discontinuation of AUDA at 4 wk of age.	epoxyeicosatrienoic acids	96-121	epoxide hydrolase 2	Rattus norvegicus	72-75
21266668-1	2011	We hypothesized that perinatal inhibition of soluble epoxide hydrolase (SEH), which metabolizes epoxyeicosatrienoic acids in the arachidonic acid (AA) cascade, with an orally active SEH inhibitor, 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), would persistently reduce blood pressure (BP) in adult SHR despite discontinuation of AUDA at 4 wk of age.	epoxyeicosatrienoic acids	96-121	epoxide hydrolase 2	Rattus norvegicus	182-185
20433684-4	2011	Soluble epoxide hydrolase (sEH) is an enzyme that catalyzes the hydrolysis of epoxyeicosatrienoic acids (EETs), which are lipid mediators derived from arachidonic acid through the cytochrome P450 epoxygenase pathway.	epoxyeicosatrienoic acids	78-103	epoxide hydrolase 2	Homo sapiens	0-25
20433684-4	2011	Soluble epoxide hydrolase (sEH) is an enzyme that catalyzes the hydrolysis of epoxyeicosatrienoic acids (EETs), which are lipid mediators derived from arachidonic acid through the cytochrome P450 epoxygenase pathway.	epoxyeicosatrienoic acids	78-103	epoxide hydrolase 2	Homo sapiens	27-30
21217101-6	2011	This is of particular physiological relevance because sEH is emerging as a novel drug target due to its major role in the hydrolysis of important lipid signaling molecules such as epoxyeicosatrienoic acids.	epoxyeicosatrienoic acids	180-205	epoxide hydrolase 2	Homo sapiens	54-57