PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21558026-0	2011	Induction of hypoxia inducible factor (HIF-1alpha) in rat kidneys by iron chelation with the hydroxypyridinone, CP94.	1,2-diethyl-3-hydroxypyridin-4-one	112-116	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	39-49
21558026-3	2011	We show that induction of HIF-1alpha in rat kidneys can be achieved by iron reduction by the hydroxypyridin-4 one (CP94), an iron chelator administered intraperitoneally in rats.	1,2-diethyl-3-hydroxypyridin-4-one	115-119	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	26-36
15182309-2	2004	Earlier studies have shown that 5-HT(1B)-knockout (KO) mice eat more and are heavier than wild-type (WT) controls and that the selective 5-HT(1B) receptor agonist CP-94,253 reduces food intake in food-deprived mice.	1,2-diethyl-3-hydroxypyridin-4-one	163-168	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	32-39
18071678-2	2008	OBJECTIVE: These experiments examine a 5-HT(1B) agonist, CP-94,253, and attempt to distinguish between its effects on seeking to perform three rewarding behaviors: aggression, drinking, and wheel running.	1,2-diethyl-3-hydroxypyridin-4-one	57-62	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	39-46
16470405-5	2006	RESULTS: The 5-HT(2C/1B) receptor agonist mCPP and the selective 5-HT1B receptor agonist CP-94,253 both suppressed food intake in WT mice.	1,2-diethyl-3-hydroxypyridin-4-one	89-94	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	65-80
17440711-6	2007	In the first experiment, the 5-HT(1B) receptor agonist, CP-94,253 (0-10 mg/kg, IP), was given 30 min before the FI 10 schedule.	1,2-diethyl-3-hydroxypyridin-4-one	56-61	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	29-46
17440711-7	2007	To confirm that CP-94,253 achieved its effects via 5-HT(1B) receptors, the 5HT(1B/1D) receptor antagonist, GR 127,935 (10 mg/kg, IP) was administrated before the agonist injection.	1,2-diethyl-3-hydroxypyridin-4-one	16-21	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	51-58
17440711-7	2007	To confirm that CP-94,253 achieved its effects via 5-HT(1B) receptors, the 5HT(1B/1D) receptor antagonist, GR 127,935 (10 mg/kg, IP) was administrated before the agonist injection.	1,2-diethyl-3-hydroxypyridin-4-one	16-21	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	75-81
15182309-2	2004	Earlier studies have shown that 5-HT(1B)-knockout (KO) mice eat more and are heavier than wild-type (WT) controls and that the selective 5-HT(1B) receptor agonist CP-94,253 reduces food intake in food-deprived mice.	1,2-diethyl-3-hydroxypyridin-4-one	163-168	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	137-144
15182309-3	2004	Here we characterize the behavioural effects of both CP-94,253 and the selective 5-HT(1B) receptor antagonist SB224289 on feeding and other behaviours within the behavioural satiety sequence, and also report a c-fos mapping study using CP-94,253.	1,2-diethyl-3-hydroxypyridin-4-one	53-58	FBJ osteosarcoma oncogene	Mus musculus	210-215
15182309-7	2004	CP-94,253 induced c-fos in a range of structures previously implicated in the expression of feeding behaviour.	1,2-diethyl-3-hydroxypyridin-4-one	0-5	FBJ osteosarcoma oncogene	Mus musculus	18-23
14996544-5	2004	A combination of the 5-HT1B receptor agonist CP-94,253 (20 mg/kg) and the 5-HT1A receptor agonist 8-OH-DPAT (0.5 mg/kg) induced marked hyperactivity in WT but not in 5-HT2C KO mice, nor in mice treated with the selective 5-HT2C receptor antagonist, SB 242084 (1.5 mg/kg).	1,2-diethyl-3-hydroxypyridin-4-one	45-50	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	21-36
14996544-5	2004	A combination of the 5-HT1B receptor agonist CP-94,253 (20 mg/kg) and the 5-HT1A receptor agonist 8-OH-DPAT (0.5 mg/kg) induced marked hyperactivity in WT but not in 5-HT2C KO mice, nor in mice treated with the selective 5-HT2C receptor antagonist, SB 242084 (1.5 mg/kg).	1,2-diethyl-3-hydroxypyridin-4-one	45-50	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	221-236
10550489-0	1999	Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253.	1,2-diethyl-3-hydroxypyridin-4-one	107-112	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	81-98
12162714-4	2002	By comparing the spectral characteristics of the CP94 3-O- and 4-O-methyl derivatives with CP94 and the CP94 glucuronides formed during incubation, evidence was obtained which enabled the assignment of these two isomeric glucuronides to the 3-O-glucuronide and 4-O-glucuronide of CP94.	1,2-diethyl-3-hydroxypyridin-4-one	91-95	surfactant protein D	Rattus norvegicus	49-64
10688630-6	2000	The present findings suggest that, on systemic administration, both 8-OH-PIPAT and CP 94,253 are potent and selective agonists at the somatodendritic 5-HT(1A) autoreceptor and terminal 5-HT(1B/1D) autoreceptor, respectively, and are each able to cause decreases in extracellular levels of 5-HT in the mouse striatum by activating a distinct set of receptors.	1,2-diethyl-3-hydroxypyridin-4-one	83-88	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	150-157
10550489-2	1999	OBJECTIVES: To investigate and compare the effects of a 5-HT(1B) selective agonist, CP-94,253, on aggression that was heightened as a result of 1) social instigation or 2) alcohol treatment.	1,2-diethyl-3-hydroxypyridin-4-one	84-89	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	56-63
10402674-2	1999	A quantitative investigation of A1(III) complex equilibria with desferrioxamine, 2,3-dihydroxybenzoic acid, Tiron, CP20 (L1), and CP94 under physiological conditions, and computer-aided assessment of the aluminum-mobilizing capacities of these ligands in vivo.	1,2-diethyl-3-hydroxypyridin-4-one	130-134	BCL2 related protein A1	Homo sapiens	32-39
8417963-7	1993	Addition of further iron-saturated transferrin also corrected inhibition by the CP94-iron complex.	1,2-diethyl-3-hydroxypyridin-4-one	80-84	transferrin	Mus musculus	35-46
7501681-6	1995	The behavioural profile of CP-94,253, but not CGS 12066B, supports the proposal that 5-HT1B receptors inhibit agonistic behaviour without concomitant sedative or anxiogenic effects.	1,2-diethyl-3-hydroxypyridin-4-one	27-32	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	85-91
9440321-2	1997	In addition, the iron chelator 1,2-diethyl-3-hydroxypyridin-4-one (CP94) was used.	1,2-diethyl-3-hydroxypyridin-4-one	31-65	beaded filament structural protein 1	Homo sapiens	67-71
9028337-8	1997	The results show that CP94 could cause protoporphyria in individuals of low iron status, perhaps through specifically targeting particular iron pools available to ferrochelatase and by concomitantly stimulating heme synthesis.	1,2-diethyl-3-hydroxypyridin-4-one	22-26	ferrochelatase	Mus musculus	163-177
7981322-0	1994	HPLC determination of 1,2-diethyl-3-hydroxypyridin-4-one (CP94), its iron complex [Fe(III) (CP94)3] and glucuronide conjugate [CP94-GLUC] in serum and urine of thalassaemic patients.	1,2-diethyl-3-hydroxypyridin-4-one	22-56	beaded filament structural protein 1	Homo sapiens	58-62
7981322-1	1994	Sensitive and selective high performance liquid chromatographic (HPLC) methods for the quantification of 1,2-diethyl-3-hydroxypyridin-4-one (CP94), its iron complex [Fe(III) (CP94)3] and glucuronide metabolite (CP94-GLUC) in urine and serum of thalassaemic patients are described.	1,2-diethyl-3-hydroxypyridin-4-one	105-139	beaded filament structural protein 1	Homo sapiens	141-145
8251385-0	1993	Contrasting interspecies efficacy and toxicology of 1,2-diethyl-3-hydroxypyridin-4-one, CP94, relates to differing metabolism of the iron chelating site.	1,2-diethyl-3-hydroxypyridin-4-one	52-86	beaded filament structural protein 1	Rattus norvegicus	88-92
1564101-1	1992	A sensitive and selective high-performance liquid chromatographic (HPLC) method for the analysis of 1,2-diethyl-3-hydroxypyridin-4-one (CP94, I) and its 2-(1-hydroxyethyl) metabolite (II) in rat blood is described.	1,2-diethyl-3-hydroxypyridin-4-one	100-134	beaded filament structural protein 1	Rattus norvegicus	136-140
27888284-6	2017	Intracranial infusions of CP 94,253 (0, 0.25, 0.5, or 1.0 mug/side) were administered to inhibit local 5-HT release via activation of 5-HT1B autoreceptors.	1,2-diethyl-3-hydroxypyridin-4-one	26-31	5-hydroxytryptamine receptor 1B	Rattus norvegicus	134-140