PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21548881-9	2011	The structure of DUT1 and site-directed mutagenesis support a role of the conserved Phe142 in the interaction with the uracil base.	polyphenylalanine	84-90	bifunctional dITP/dUTP diphosphatase	Saccharomyces cerevisiae S288C	17-21
30970526-0	2019	The interaction between CSE/H2S and the iNOS/NO-mediated resveratrol/poly(ethylene glycol)-poly(phenylalanine) complex alleviates intestinal ischemia/reperfusion injuries in diabetic rats.	polyphenylalanine	91-110	cystathionine gamma-lyase	Rattus norvegicus	24-27
30970526-0	2019	The interaction between CSE/H2S and the iNOS/NO-mediated resveratrol/poly(ethylene glycol)-poly(phenylalanine) complex alleviates intestinal ischemia/reperfusion injuries in diabetic rats.	polyphenylalanine	91-110	nitric oxide synthase 2	Rattus norvegicus	40-44
8714201-10	1995	Poly(U)-directed polyphenylalanine synthesis by yeast ribosomes is inhibited by dC6.	polyphenylalanine	17-34	labial associated factor	Drosophila melanogaster	80-83
15094376-3	2004	Both globular monomeric (G-actin) and filamentous (F-actin) forms of actin appear to be inhibitory on the action of elongation factors 1 and 2 (eEF1 and eEF2) in polyPhe synthesis with the inhibitory effect of G-actin proving to be stronger.	polyphenylalanine	162-169	eukaryotic translation elongation factor 1 alpha 1	Rattus norvegicus	144-148
15094376-3	2004	Both globular monomeric (G-actin) and filamentous (F-actin) forms of actin appear to be inhibitory on the action of elongation factors 1 and 2 (eEF1 and eEF2) in polyPhe synthesis with the inhibitory effect of G-actin proving to be stronger.	polyphenylalanine	162-169	eukaryotic translation elongation factor 2	Rattus norvegicus	153-157
15094376-4	2004	Some component(s) in the postribosomal supernatant (S-130) fraction and also DNase I prevent actin-promoted inhibition of polyPhe synthesis.	polyphenylalanine	122-129	deoxyribonuclease 1	Rattus norvegicus	77-84
12460565-1	2002	Translation of polyphenylalanine from a polyuridine template by the ribosome in the absence of the elongation factors EFG and EFTu (and the energy derived from GTP hydrolysis) is promoted by modification of the ribosome with thiol-specific reagents such as para-chloromercuribenzoate (pCMB).	polyphenylalanine	15-32	Tu translation elongation factor, mitochondrial	Homo sapiens	126-130
9150873-10	1996	In polyphenylalanine synthesis programmed by polyuridylic acid, misincorporation of isoleucine, leucine or a mixture of amino acids was stimulated upto 17-fold when RRF was omitted from the in vitro system.	polyphenylalanine	3-20	mitochondrial ribosome recycling factor	Homo sapiens	165-168
12785003-6	2003	Endotoxin elicited clinical signs of an inflammatory reaction, prominent release of all cytokines and O2- synthesis by neutrophils (N-formyl-methionin-leucyl-phenylalanin-stimulated cells measured by cytochrome C reduction).	polyphenylalanine	158-170	cytochrome c, somatic	Homo sapiens	200-212
7957240-14	1994	In an in vitro system, one can demonstrate a small but consistent stimulatory effect of yeast EF-3 on polyphenylalanine synthesis by pig liver ribosomes only when EF-1 alpha is present at a limited concentration.	polyphenylalanine	102-119	EF1ALPHA	Sus scrofa	163-173
2050694-7	1991	Phosphorylation of valyl-tRNA synthetase in response to PMA is reproducibly accompanied by a 1.7-fold increase in aminoacylation activity, whereas phosphorylation of EF-1 is associated with a 2.0-2.2-fold stimulation of activity, as measured by poly(U)-directed polyphenylalanine synthesis.	polyphenylalanine	262-279	valine--tRNA ligase	Oryctolagus cuniculus	19-40
8075071-6	1994	In poly(U)-directed poly(phenylalanine) synthesis, the number of peptide chains synthesized using EF-Tu D138N.XTP was 30% higher than with EF-Tu wild type (wt).GTP.	polyphenylalanine	20-39	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	98-103
8075071-6	1994	In poly(U)-directed poly(phenylalanine) synthesis, the number of peptide chains synthesized using EF-Tu D138N.XTP was 30% higher than with EF-Tu wild type (wt).GTP.	polyphenylalanine	20-39	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	139-144
2061327-11	1991	Phosphorylation of the valyl-tRNA synthetase.EF-1 complex results in a 3-fold increase in activity of EF-1 as measured by poly(U)-directed polyphenylalanine synthesis; no effect of phosphorylation is detected with valyl-tRNA synthetase and isolated EF-1 alpha.	polyphenylalanine	139-156	valine--tRNA ligase	Oryctolagus cuniculus	23-44
35609420-4	2022	Biochemical functional assays showed that RA-VII inhibits poly(U)-dependent polyphenylalanine synthesis in the presence of animal elongation factors eEF1A and eEF2.	polyphenylalanine	76-93	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	149-154
1989969-6	1991	Anti-28 S and its Fab fragments strongly inhibited poly(U)-directed polyphenylalanine synthesis, but had no effect on ribosomal peptidyltransferase activity.	polyphenylalanine	68-85	FA complementation group B	Homo sapiens	18-21
2157494-11	1990	The binding of GTPox to EF-2 inhibited only partially the subsequent ribosome-dependent GTP binding, and GTPase reaction or polyphenylalanine (polyPhe) synthesis.	polyphenylalanine	124-141	eukaryotic translation elongation factor 2	Rattus norvegicus	24-28
2157494-11	1990	The binding of GTPox to EF-2 inhibited only partially the subsequent ribosome-dependent GTP binding, and GTPase reaction or polyphenylalanine (polyPhe) synthesis.	polyphenylalanine	143-150	eukaryotic translation elongation factor 2	Rattus norvegicus	24-28
35609420-4	2022	Biochemical functional assays showed that RA-VII inhibits poly(U)-dependent polyphenylalanine synthesis in the presence of animal elongation factors eEF1A and eEF2.	polyphenylalanine	76-93	eukaryotic translation elongation factor 2	Homo sapiens	159-163
3142291-1	1988	Two novel affinity tails, polycysteine and polyphenylalanine, have been genetically attached to galactokinase (EC 2.7.1.6) and beta-galactosidase (EC 3.2.1.23) in order to facilitate their purification.	polyphenylalanine	43-60	galactosidase beta 1	Homo sapiens	127-145
974064-1	1976	The extent of the inhibitory effect of ricin in polyphenylalanine synthesis by eukaryotic ribosomes is strongly dependent upon the concentration of ribosomes and the elongation factors EF 1 and EF2.	polyphenylalanine	48-65	eukaryotic translation elongation factor 2	Homo sapiens	194-197
3386756-5	1988	This work shows that the phosphorylation of EF-2 by the EF-2 kinase results in a drastic inhibition of polyphenylalanine synthesis in poly(U)-directed translation.	polyphenylalanine	103-120	eukaryotic translation elongation factor 2	Homo sapiens	44-48
3386756-5	1988	This work shows that the phosphorylation of EF-2 by the EF-2 kinase results in a drastic inhibition of polyphenylalanine synthesis in poly(U)-directed translation.	polyphenylalanine	103-120	eukaryotic translation elongation factor 2	Homo sapiens	56-60
7017364-1	1981	Des-phe-insulins are modified insulins in which phenylalanin is eliminated from the b-chain of the normal insulin.	polyphenylalanine	48-60	insulin	Homo sapiens	8-15
7440577-3	1980	Beta-Endorphin, Leu-enkephalin, and Met-enkephalin inhibit the incorporation of radioactive leucine into globin in the presence of reticulocyte poly(A)+ RNA and of radioactive phenylalanine into polyphenylalanine in the presence of poly(U); however, the poly(U)-dependent synthesis of polyphenylalanine from Phe-tRNA is not inhibited.	polyphenylalanine	195-212	proopiomelanocortin	Homo sapiens	0-14
7440577-3	1980	Beta-Endorphin, Leu-enkephalin, and Met-enkephalin inhibit the incorporation of radioactive leucine into globin in the presence of reticulocyte poly(A)+ RNA and of radioactive phenylalanine into polyphenylalanine in the presence of poly(U); however, the poly(U)-dependent synthesis of polyphenylalanine from Phe-tRNA is not inhibited.	polyphenylalanine	195-212	prodynorphin	Homo sapiens	16-30
7440577-3	1980	Beta-Endorphin, Leu-enkephalin, and Met-enkephalin inhibit the incorporation of radioactive leucine into globin in the presence of reticulocyte poly(A)+ RNA and of radioactive phenylalanine into polyphenylalanine in the presence of poly(U); however, the poly(U)-dependent synthesis of polyphenylalanine from Phe-tRNA is not inhibited.	polyphenylalanine	195-212	proopiomelanocortin	Homo sapiens	36-50
7440577-3	1980	Beta-Endorphin, Leu-enkephalin, and Met-enkephalin inhibit the incorporation of radioactive leucine into globin in the presence of reticulocyte poly(A)+ RNA and of radioactive phenylalanine into polyphenylalanine in the presence of poly(U); however, the poly(U)-dependent synthesis of polyphenylalanine from Phe-tRNA is not inhibited.	polyphenylalanine	285-302	proopiomelanocortin	Homo sapiens	0-14
7440577-3	1980	Beta-Endorphin, Leu-enkephalin, and Met-enkephalin inhibit the incorporation of radioactive leucine into globin in the presence of reticulocyte poly(A)+ RNA and of radioactive phenylalanine into polyphenylalanine in the presence of poly(U); however, the poly(U)-dependent synthesis of polyphenylalanine from Phe-tRNA is not inhibited.	polyphenylalanine	285-302	prodynorphin	Homo sapiens	16-30
7440577-3	1980	Beta-Endorphin, Leu-enkephalin, and Met-enkephalin inhibit the incorporation of radioactive leucine into globin in the presence of reticulocyte poly(A)+ RNA and of radioactive phenylalanine into polyphenylalanine in the presence of poly(U); however, the poly(U)-dependent synthesis of polyphenylalanine from Phe-tRNA is not inhibited.	polyphenylalanine	285-302	proopiomelanocortin	Homo sapiens	36-50
488904-4	1979	The protein/polyphenylalanine ratio which represents a ratio of polysomes to monosomes was found increased in ribosomes from the gastrin-treated groups.	polyphenylalanine	12-29	gastrin	Homo sapiens	129-136
827374-1	1976	Poly U dependent polyphenylalanine synthesis from 14C phenylalanyl-tRNA, under known optimal conditions, in ribosomes obtained from NaF-treated Rabbit reticulocytes, is only slightly stimulated by the addition of ATP, GTP and UTP in the absence of phosphoenolpyruvate and pyruvate kinase.	polyphenylalanine	17-34	pyruvate kinase PKLR	Oryctolagus cuniculus	272-287
789367-2	1976	Concomitant with this inhibition, an increase in the activity of ribosome-bound EF-2 in polyphenylalanine synthesis was observed.	polyphenylalanine	88-105	eukaryotic translation elongation factor 2	Homo sapiens	80-84
3693353-14	1987	Dephospho-EF-2 could support poly(U)-directed polyphenylalanine synthesis in a reconstituted elongation system when combined with EF-1.	polyphenylalanine	46-63	eukaryotic translation elongation factor 2	Homo sapiens	10-14
6798570-1	1982	The notion that tRNA and 5S rRNA interact through evolutionarily conserved complementary sequences has been tested by nucleolytic modification of the 5S rRNA, using the modified rRNA to reconstitute the large ribosomal subunit, and assaying for poly(uridylic acid)-directed polyphenylalanine synthesis.	polyphenylalanine	274-291	mitochondrially encoded tRNA glycine	Homo sapiens	16-20
6104671-0	1980	The coupling with polypeptide synthesis of the GTPase activity dependent on elongation factor G. The coupling with polypeptide synthesis of the ribosome-elongation factor G (EF-G)-dependent GTPase activity was studied in a highly purified system with well characterized NH4Cl-washed ribosomes which were from 55 to 67% active in poly(U)-directed polyphenylalanine synthesis.	polyphenylalanine	346-363	G elongation factor mitochondrial 1	Homo sapiens	144-172
6104671-0	1980	The coupling with polypeptide synthesis of the GTPase activity dependent on elongation factor G. The coupling with polypeptide synthesis of the ribosome-elongation factor G (EF-G)-dependent GTPase activity was studied in a highly purified system with well characterized NH4Cl-washed ribosomes which were from 55 to 67% active in poly(U)-directed polyphenylalanine synthesis.	polyphenylalanine	346-363	G elongation factor mitochondrial 1	Homo sapiens	174-178
6104671-3	1980	Under this condition, the apparent Km values for GTP of GTPase activity and polyphenylalanine synthesis are identical, and they are about an order of magnitude lower than the Km of the ribosome-EF-G-dependent GTPase activity uncoupled from polypeptide synthesis.	polyphenylalanine	76-93	G elongation factor mitochondrial 1	Homo sapiens	194-198
6989829-2	1980	Of the 18 Fabs tested, 3, anti-S10, anti-S12, and anti-S14, inhibited polyphenylalanine synthesis; antibodies against 3 of the 21 E. coli ribosomal proteins (S1, S16, and S17) were not tested.	polyphenylalanine	70-87	thyroid hormone responsive	Rattus norvegicus	55-58
395311-0	1979	Polyphenylalanine synthesis by crystallized trypsin-modified EF-Tu.GDP.	polyphenylalanine	0-17	Tu translation elongation factor, mitochondrial	Homo sapiens	61-66
340910-7	1977	In heterozygous (+/cry1) diploids both the sensitive and the resistant genes are expressed as shown by studies of the action of cryptopleurine on polyphenylalanine-synthesizing systems derived from each parental sensitive and resistant haploid strain and heterozygous diploid strains.	polyphenylalanine	146-163	ribosomal 40S subunit protein S14A	Saccharomyces cerevisiae S288C	19-23
853201-0	1977	Discontinuing the phenylalamine-restricted diet in young children with PKY.	polyphenylalanine	18-31	homeodomain interacting protein kinase 3	Homo sapiens	71-74
13996-6	1977	By means of 1H nuclear magnetic resonance spectroscopy and the action of D and L-amino acid oxidase the configuration of the phenylalamine has been shown to be (2R, 3S) and (2S, 3S), respectively.	polyphenylalanine	125-138	interleukin 4 induced 1	Homo sapiens	79-99
942410-0	1976	Prevention, by ribosome-bound nascent polyphenylalanine chains, of the functional interaction of t-2 toxin with its receptor site.	polyphenylalanine	38-55	solute carrier family 25 member 5	Homo sapiens	97-100
942410-2	1976	The inhibitory effects of T-2 toxin and trichodermin on poly(U)-directed polyphenylalanine synthesis were studied by using cell-free systems from reticulocytes.	polyphenylalanine	73-90	solute carrier family 25 member 5	Homo sapiens	26-29
942410-8	1976	In contrast, although T-2 toxin (40 mug/ml), when added at early incubation times, could inhibit polyphenylalanine synthesis with a maximum of 50%, the drug had no effect on the system when added after a critical time-period.	polyphenylalanine	97-114	solute carrier family 25 member 5	Homo sapiens	22-25
4643323-9	1972	A correlation was found between the ability of cell sap to stimulate polyphenylalanine synthesis and the relative cholesteryl 14-methylhexadecanoate content in the postmicrosomal supernatant at different time-intervals after administration of the ester.	polyphenylalanine	69-86	amyloid P component, serum	Rattus norvegicus	52-55
4619014-2	1974	Ricin, a toxic protein from the seeds of Ricinus communis which inhibits poly(U)-directed polyphenylalanine synthesis by rat liver ribosomes (Montanaro et al., 1973), does not affect protein synthesis by isolated rat liver mitochondria.	polyphenylalanine	90-107	ricin	Ricinus communis	0-5
4741155-0	1973	Polymerization of DL-phenylalanine NCA initiated by copolymer of sarcosine and DL-phenylalanine.	polyphenylalanine	18-34	CEA cell adhesion molecule 6	Homo sapiens	35-38
4741155-0	1973	Polymerization of DL-phenylalanine NCA initiated by copolymer of sarcosine and DL-phenylalanine.	polyphenylalanine	79-95	CEA cell adhesion molecule 6	Homo sapiens	35-38