PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2993772-6 1985 Both extrinsic and intrinsic asthmatics had significantly enhanced 5-lipoxygenase activity, which was expressed as the sum of percentage conversion of 14C-arachidonic acid into 5-HETE and 5,12-diHETE. 14c-arachidonic acid 151-171 arachidonate 5-lipoxygenase Homo sapiens 67-81 3923563-1 1985 5,8,11,14-eicosatetraynoic acid (ETYA), a widely used inhibitor of cyclooxygenase and lipoxygenase, inhibited the incorporation of 14C-arachidonic acid into cell lipids of the murine thymoma EL4 whereas oleic acid had no effect. 14c-arachidonic acid 131-151 epilepsy 4 Mus musculus 191-194 6431000-11 1984 Incorporation of 14C-arachidonic acid into 23A4 cells, followed by stimulation of the cells with GEF, resulted in the release of 14C-arachidonate. 14c-arachidonic acid 17-37 rho/rac guanine nucleotide exchange factor (GEF) 2 Mus musculus 97-100 6431565-1 1984 When human polymorphonuclear leukocytes (PMNL) were incubated with exogenous 14C-arachidonic acid only traces of 5-lipoxygenase products including 5-HETE and leukotriene B4 were detected. 14c-arachidonic acid 77-97 arachidonate 5-lipoxygenase Homo sapiens 113-127 6421543-1 1984 In the present study we compared the synthesis of various cyclooxygenase products in albino rabbit, dog (puppy and adult), cat, cow and human ocular tissues from 14C-arachidonic acid (AA). 14c-arachidonic acid 162-182 prostaglandin-endoperoxide synthase 1 Canis lupus familiaris 58-72 6819604-7 1982 Endothelial cells released 14C-arachidonic acid as well as 14C-prostaglandins in response to either histamine or bradykinin. 14c-arachidonic acid 27-47 kininogen 1 Homo sapiens 113-123 7030066-3 1981 In paired experiments, in the presence of endotoxin, the addition of the aggregating agent thrombin (0.5 U/ml) caused human platelets to release 29.1 +/- 3.4% of 14C-arachidonic acid from prelabeled platelet phospholipids. 14c-arachidonic acid 162-182 coagulation factor II, thrombin Homo sapiens 91-99 197570-4 1977 The influence of PGE1 with theophylline, and dibutyryl cyclic AMP on the thrombin induced release of 14C-arachidonic acid from platelet membrane phospholipids was also investigated. 14c-arachidonic acid 101-121 coagulation factor II, thrombin Homo sapiens 73-81 9211348-6 1997 Compared to adults, neonates had a lower renal cortical cytosolic PLA2 (cPLA2) activity, assessed as the release of 14C-arachidonic acid (AA) from labeled phosphatidyl choline (0.44 +/- 0.10 vs. 0.74 +/- 0.06% 14C-AA released/min/mg protein, P < 0.05) and microsomal PLA2 activity (0.32 +/- 0.03 vs. 1.20 +/- 0.13% 14C-AA released/min/mg protein, P < 0.001). 14c-arachidonic acid 116-136 cytosolic phospholipase A2 Oryctolagus cuniculus 72-77 9211348-6 1997 Compared to adults, neonates had a lower renal cortical cytosolic PLA2 (cPLA2) activity, assessed as the release of 14C-arachidonic acid (AA) from labeled phosphatidyl choline (0.44 +/- 0.10 vs. 0.74 +/- 0.06% 14C-AA released/min/mg protein, P < 0.05) and microsomal PLA2 activity (0.32 +/- 0.03 vs. 1.20 +/- 0.13% 14C-AA released/min/mg protein, P < 0.001). 14c-arachidonic acid 116-136 phospholipase A2 Oryctolagus cuniculus 66-70 8106748-7 1994 Finally, UVA exposure almost completely abolished the EGF-induced increase in diacylglycerol production from 14C-arachidonic acid-labeled lipids in both cell types. 14c-arachidonic acid 109-129 epidermal growth factor Homo sapiens 54-57 2968795-3 1988 The activity of cellular phospholipase A2 was considered as the release of free 14C-Arachidonic acid in the cell supernatant. 14c-arachidonic acid 80-100 phospholipase A2, group IB, pancreas Mus musculus 25-41 3203637-6 1988 PLA2 was measured by the liberation of 14C-arachidonic acid from 1-stearoyl-2-[1-14C]arachidonyl-L-3-phosphatidylcholine. 14c-arachidonic acid 39-59 phospholipase A2 group IB Homo sapiens 0-4 2836681-2 1988 The reaction was dependent on lipoxygenation, was potentiated by indomethacin (IM) and was inhibited by nordihidro-guairetic acid (NDGA), (iii) both 14C-arachidonic acid (14C-AA) release and leukotriene B4 (LTB4) synthesis of ME-treated PMNLs were elevated as compared to those of FMLP triggered cells. 14c-arachidonic acid 149-169 formyl peptide receptor 1 Homo sapiens 281-285 3131780-1 1988 In an attempt to elucidate the possible involvements of eicosanoids in esophageal functions and disorders, we have investigated the formation of both cyclooxygenase and lipoxygenase metabolites from 14C-arachidonic acid by rabbit esophageal tissues. 14c-arachidonic acid 199-219 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 169-181 3131780-9 1988 The present findings indicate that rabbit esophageal tissues can convert 14C-arachidonic acid into lipoxygenase as well cyclo-oxygenase products which may have a role in esophageal physiology and pathophysiology. 14c-arachidonic acid 73-93 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 99-111 3124291-2 1987 Bovine coronary endothelial cells converted 14C-arachidonic acid to radioactive 6-keto PGF1 alpha (the stable metabolite of PGI2) and to a lesser extent PGE2. 14c-arachidonic acid 44-64 prostaglandin F synthase 2 Bos taurus 87-91 2444995-2 1987 Bradykinin, histamine, and phosphatidic acid were found to liberate 14C-arachidonic acid from membrane phospholipids, whereas leukotrienes B4 and C4 were ineffective in this respect. 14c-arachidonic acid 68-88 kininogen 1 Homo sapiens 0-10 3936117-2 1985 Here the presence of 5-lipoxygenase activity in the whole ovary and in the Graafian follicle is estimated by a chemiluminescence assay using unlabeled arachidonic acid as substrate in the presence of luminol and by conversion of 14C-arachidonic acid into lipoxygenase products as separated by HPLC. 14c-arachidonic acid 229-249 arachidonate 5-lipoxygenase Rattus norvegicus 21-35