PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29034965-0	2018	Role of serum albumin as a nanoparticulate carrier for nose-to-brain delivery of R-flurbiprofen: implications for the treatment of Alzheimer"s disease.	tarenflurbil	81-95	albumin	Mus musculus	8-21
19916560-0	2010	R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75(NTR) induction.	tarenflurbil	0-14	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	102-105
22072415-7	2011	Eadie-Hofstee plot analysis showed that (S)-flurbiprofen and (R)-flurbiprofen inhibited hOAT1 and hOAT3 in a competitive manner.	tarenflurbil	61-77	solute carrier family 22 member 6	Homo sapiens	88-93
22072415-7	2011	Eadie-Hofstee plot analysis showed that (S)-flurbiprofen and (R)-flurbiprofen inhibited hOAT1 and hOAT3 in a competitive manner.	tarenflurbil	61-77	solute carrier family 22 member 8	Homo sapiens	98-103
21097678-1	2010	The nonsteroidal anti-inflammatory drugs (NSAID) R-flurbiprofen and ibuprofen have been shown to induce expression of p75(NTR) (neurotrophin receptor) in prostate cancer cell lines.	tarenflurbil	49-63	neurotensin receptor 1	Homo sapiens	118-126
21097678-5	2010	Here, we show that treatment with R-flurbiprofen and ibuprofen induces expression of the NSAID-activated gene-1 (Nag-1) protein, a divergent member of the TGF beta (TGF-beta) family, in PC-3 cells.	tarenflurbil	34-48	growth differentiation factor 15	Homo sapiens	89-111
21097678-5	2010	Here, we show that treatment with R-flurbiprofen and ibuprofen induces expression of the NSAID-activated gene-1 (Nag-1) protein, a divergent member of the TGF beta (TGF-beta) family, in PC-3 cells.	tarenflurbil	34-48	growth differentiation factor 15	Homo sapiens	113-118
21097678-5	2010	Here, we show that treatment with R-flurbiprofen and ibuprofen induces expression of the NSAID-activated gene-1 (Nag-1) protein, a divergent member of the TGF beta (TGF-beta) family, in PC-3 cells.	tarenflurbil	34-48	transforming growth factor beta 1	Homo sapiens	155-163
21097678-5	2010	Here, we show that treatment with R-flurbiprofen and ibuprofen induces expression of the NSAID-activated gene-1 (Nag-1) protein, a divergent member of the TGF beta (TGF-beta) family, in PC-3 cells.	tarenflurbil	34-48	transforming growth factor beta 1	Homo sapiens	165-173
20937024-10	2010	Genistein, alpha-difluoromethylornithine, toremifene, R-flurbiprofen, celecoxib, and green tea polyphenols have been shown to prevent prostate cancer development in TRAMP mice.	tarenflurbil	54-68	tumor necrosis factor receptor superfamily, member 25	Mus musculus	165-170
19916560-4	2010	Nevertheless, when gastric cancer cells were treated with different NSAIDs, the non-Cox-2-inhibiting R-flurbiprofen was most effective at reducing proliferation of gastric cancer cells in vitro.	tarenflurbil	101-115	cytochrome c oxidase II, mitochondrial	Mus musculus	84-89
19916560-7	2010	Mechanistically, R-flurbiprofen was found to have pleiotropic effects, changing levels of cell cycle factors like Cyclin D1 and CKD4, apoptotic protwins like caspase3 and Bcl-2, and protwins that affect metastasis, like metalloproteases.	tarenflurbil	17-31	cyclin D1	Mus musculus	114-123
18090435-0	2007	Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals.	tarenflurbil	92-106	amyloid beta precursor protein	Homo sapiens	44-49
19916560-7	2010	Mechanistically, R-flurbiprofen was found to have pleiotropic effects, changing levels of cell cycle factors like Cyclin D1 and CKD4, apoptotic protwins like caspase3 and Bcl-2, and protwins that affect metastasis, like metalloproteases.	tarenflurbil	17-31	caspase 3	Mus musculus	158-166
19916560-7	2010	Mechanistically, R-flurbiprofen was found to have pleiotropic effects, changing levels of cell cycle factors like Cyclin D1 and CKD4, apoptotic protwins like caspase3 and Bcl-2, and protwins that affect metastasis, like metalloproteases.	tarenflurbil	17-31	B cell leukemia/lymphoma 2	Mus musculus	171-176
19916560-8	2010	Consistent with reports on other cancer cell types, NSAID treatment with R-flurbiprofen increased levels of the tumor suppressor neurotrophin receptor (p75(NTR)) in gastric cancer cells.	tarenflurbil	73-87	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	152-155
19916560-9	2010	The anticancer effects of R-flurbiprofen were found to require induction of p75(NTR) via the p38 signaling pathway, suggesting a possible mechanism of action.	tarenflurbil	26-40	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	76-79
19916560-9	2010	The anticancer effects of R-flurbiprofen were found to require induction of p75(NTR) via the p38 signaling pathway, suggesting a possible mechanism of action.	tarenflurbil	26-40	mitogen-activated protein kinase 14	Mus musculus	93-96
20930267-4	2010	We report that ibuprofen (100-500 muM), R-flurbiprofen (100-500 muM), and CHF5074 (10-30 muM) caused a concentration-dependent stellation of astrocytes in primary cultures, associated with the reorganization of GFAP and actin filaments.	tarenflurbil	40-54	latexin	Homo sapiens	64-67
20930267-4	2010	We report that ibuprofen (100-500 muM), R-flurbiprofen (100-500 muM), and CHF5074 (10-30 muM) caused a concentration-dependent stellation of astrocytes in primary cultures, associated with the reorganization of GFAP and actin filaments.	tarenflurbil	40-54	latexin	Homo sapiens	64-67
20930267-4	2010	We report that ibuprofen (100-500 muM), R-flurbiprofen (100-500 muM), and CHF5074 (10-30 muM) caused a concentration-dependent stellation of astrocytes in primary cultures, associated with the reorganization of GFAP and actin filaments.	tarenflurbil	40-54	glial fibrillary acidic protein	Homo sapiens	211-215
18648507-5	2008	In addition, we found that a series of non-steroidal anti-inflammatory drugs (NSAIDs) including salicylate, sulindac sulfide, indomethacin, ibuprofen and R-flurbiprofen depolarize mitochondria and inhibit mitochondrial Ca(2+) overload, cytochrome c release and cell death induced by Abeta oligomers.	tarenflurbil	154-168	cytochrome c, somatic	Homo sapiens	236-248
18648507-5	2008	In addition, we found that a series of non-steroidal anti-inflammatory drugs (NSAIDs) including salicylate, sulindac sulfide, indomethacin, ibuprofen and R-flurbiprofen depolarize mitochondria and inhibit mitochondrial Ca(2+) overload, cytochrome c release and cell death induced by Abeta oligomers.	tarenflurbil	154-168	amyloid beta precursor protein	Homo sapiens	283-288
18056468-7	2007	We also observed that siRNA knockdown of MAPK-activated protein kinase (MK)-2 and MK3, the kinases downstream of p38 MAPK that are responsible for the mRNA stabilizing effects of the p38 MAPK pathway, also prevented an induction of p75(NTR) by R-flurbiprofen and ibuprofen.	tarenflurbil	244-258	TNF receptor superfamily member 1B	Homo sapiens	232-235
18056468-7	2007	We also observed that siRNA knockdown of MAPK-activated protein kinase (MK)-2 and MK3, the kinases downstream of p38 MAPK that are responsible for the mRNA stabilizing effects of the p38 MAPK pathway, also prevented an induction of p75(NTR) by R-flurbiprofen and ibuprofen.	tarenflurbil	244-258	neurotensin receptor 1	Homo sapiens	236-239
18056468-9	2007	Collectively, the data suggest that R-flurbiprofen and ibuprofen induce p75(NTR) expression by increased mRNA stability that is mediated through the p38 MAPK pathway.	tarenflurbil	36-50	TNF receptor superfamily member 1B	Homo sapiens	72-75
18056468-9	2007	Collectively, the data suggest that R-flurbiprofen and ibuprofen induce p75(NTR) expression by increased mRNA stability that is mediated through the p38 MAPK pathway.	tarenflurbil	36-50	neurotensin receptor 1	Homo sapiens	76-79
18056468-9	2007	Collectively, the data suggest that R-flurbiprofen and ibuprofen induce p75(NTR) expression by increased mRNA stability that is mediated through the p38 MAPK pathway.	tarenflurbil	36-50	mitogen-activated protein kinase 14	Homo sapiens	149-152
18974393-2	2008	Previously, we showed that treatment with R-flurbiprofen or ibuprofen induced p75(NTR) expression in several prostate cancer cell lines leading to p75(NTR)-mediated decreased survival.	tarenflurbil	42-56	TNF receptor superfamily member 1B	Homo sapiens	78-81
18974393-2	2008	Previously, we showed that treatment with R-flurbiprofen or ibuprofen induced p75(NTR) expression in several prostate cancer cell lines leading to p75(NTR)-mediated decreased survival.	tarenflurbil	42-56	neurotensin receptor 1	Homo sapiens	82-85
18974393-2	2008	Previously, we showed that treatment with R-flurbiprofen or ibuprofen induced p75(NTR) expression in several prostate cancer cell lines leading to p75(NTR)-mediated decreased survival.	tarenflurbil	42-56	TNF receptor superfamily member 1B	Homo sapiens	147-150
18974393-2	2008	Previously, we showed that treatment with R-flurbiprofen or ibuprofen induced p75(NTR) expression in several prostate cancer cell lines leading to p75(NTR)-mediated decreased survival.	tarenflurbil	42-56	neurotensin receptor 1	Homo sapiens	151-154
18056468-2	2007	Previously, we showed that treatment with R-flurbiprofen or ibuprofen induced p75(NTR) expression in PC-3 and DU-145 cells leading to p75(NTR)-mediated decreased survival.	tarenflurbil	42-56	TNF receptor superfamily member 1B	Homo sapiens	78-81
18056468-2	2007	Previously, we showed that treatment with R-flurbiprofen or ibuprofen induced p75(NTR) expression in PC-3 and DU-145 cells leading to p75(NTR)-mediated decreased survival.	tarenflurbil	42-56	neurotensin receptor 1	Homo sapiens	82-85
18056468-2	2007	Previously, we showed that treatment with R-flurbiprofen or ibuprofen induced p75(NTR) expression in PC-3 and DU-145 cells leading to p75(NTR)-mediated decreased survival.	tarenflurbil	42-56	TNF receptor superfamily member 1B	Homo sapiens	134-137
18056468-2	2007	Previously, we showed that treatment with R-flurbiprofen or ibuprofen induced p75(NTR) expression in PC-3 and DU-145 cells leading to p75(NTR)-mediated decreased survival.	tarenflurbil	42-56	neurotensin receptor 1	Homo sapiens	138-141
18056468-4	2007	We show that the observed increase in p75(NTR) protein due to R-flurbiprofen and ibuprofen treatment was accompanied by an increase in p75(NTR) mRNA, and this increase in mRNA was the result of increased mRNA stability and not by an up-regulation of transcription.	tarenflurbil	62-76	TNF receptor superfamily member 1B	Homo sapiens	38-41
18056468-4	2007	We show that the observed increase in p75(NTR) protein due to R-flurbiprofen and ibuprofen treatment was accompanied by an increase in p75(NTR) mRNA, and this increase in mRNA was the result of increased mRNA stability and not by an up-regulation of transcription.	tarenflurbil	62-76	neurotensin receptor 1	Homo sapiens	42-45
18056468-4	2007	We show that the observed increase in p75(NTR) protein due to R-flurbiprofen and ibuprofen treatment was accompanied by an increase in p75(NTR) mRNA, and this increase in mRNA was the result of increased mRNA stability and not by an up-regulation of transcription.	tarenflurbil	62-76	TNF receptor superfamily member 1B	Homo sapiens	135-138
18056468-4	2007	We show that the observed increase in p75(NTR) protein due to R-flurbiprofen and ibuprofen treatment was accompanied by an increase in p75(NTR) mRNA, and this increase in mRNA was the result of increased mRNA stability and not by an up-regulation of transcription.	tarenflurbil	62-76	neurotensin receptor 1	Homo sapiens	139-142
18056468-5	2007	In addition, we show that treatment with R-flurbiprofen or ibuprofen led to sustained activation of the p38 mitogen-activated protein kinase (MAPK) pathway.	tarenflurbil	41-55	mitogen-activated protein kinase 14	Homo sapiens	104-140
18056468-6	2007	Furthermore, inhibition of the p38 MAPK pathway with the p38 MAPK-specific inhibitor SB202190 or by small interfering RNA (siRNA) knockdown of p38 MAPK protein prevented induction of p75(NTR) by R-flurbiprofen and ibuprofen.	tarenflurbil	195-209	mitogen-activated protein kinase 14	Homo sapiens	31-34
18056468-6	2007	Furthermore, inhibition of the p38 MAPK pathway with the p38 MAPK-specific inhibitor SB202190 or by small interfering RNA (siRNA) knockdown of p38 MAPK protein prevented induction of p75(NTR) by R-flurbiprofen and ibuprofen.	tarenflurbil	195-209	TNF receptor superfamily member 1B	Homo sapiens	183-186
18056468-6	2007	Furthermore, inhibition of the p38 MAPK pathway with the p38 MAPK-specific inhibitor SB202190 or by small interfering RNA (siRNA) knockdown of p38 MAPK protein prevented induction of p75(NTR) by R-flurbiprofen and ibuprofen.	tarenflurbil	195-209	neurotensin receptor 1	Homo sapiens	187-190
18056468-7	2007	We also observed that siRNA knockdown of MAPK-activated protein kinase (MK)-2 and MK3, the kinases downstream of p38 MAPK that are responsible for the mRNA stabilizing effects of the p38 MAPK pathway, also prevented an induction of p75(NTR) by R-flurbiprofen and ibuprofen.	tarenflurbil	244-258	MAPK activated protein kinase 3	Homo sapiens	82-85
18056468-7	2007	We also observed that siRNA knockdown of MAPK-activated protein kinase (MK)-2 and MK3, the kinases downstream of p38 MAPK that are responsible for the mRNA stabilizing effects of the p38 MAPK pathway, also prevented an induction of p75(NTR) by R-flurbiprofen and ibuprofen.	tarenflurbil	244-258	mitogen-activated protein kinase 14	Homo sapiens	113-116
18056468-7	2007	We also observed that siRNA knockdown of MAPK-activated protein kinase (MK)-2 and MK3, the kinases downstream of p38 MAPK that are responsible for the mRNA stabilizing effects of the p38 MAPK pathway, also prevented an induction of p75(NTR) by R-flurbiprofen and ibuprofen.	tarenflurbil	244-258	mitogen-activated protein kinase 14	Homo sapiens	183-186
17409433-6	2007	The most efficacious compounds for induction of p75(NTR) and decreased survival, in rank-order, were R-flurbiprofen, ibuprofen, oxaprozin, fenoprofen, naproxen, and ketoprofen.	tarenflurbil	101-115	TNF receptor superfamily member 1B	Homo sapiens	48-51
17409433-6	2007	The most efficacious compounds for induction of p75(NTR) and decreased survival, in rank-order, were R-flurbiprofen, ibuprofen, oxaprozin, fenoprofen, naproxen, and ketoprofen.	tarenflurbil	101-115	neurotensin receptor 1	Homo sapiens	52-55
17409433-8	2007	Whereas treatment with R-flurbiprofen or ibuprofen resulted in a massive induction of p75(NTR) protein levels, the expression of Fas, p55(TNFR), DR3, DR4, DR5, and DR6 remained largely unchanged.	tarenflurbil	23-37	TNF receptor superfamily member 1B	Homo sapiens	86-89
17409433-8	2007	Whereas treatment with R-flurbiprofen or ibuprofen resulted in a massive induction of p75(NTR) protein levels, the expression of Fas, p55(TNFR), DR3, DR4, DR5, and DR6 remained largely unchanged.	tarenflurbil	23-37	neurotensin receptor 1	Homo sapiens	90-93
17409433-8	2007	Whereas treatment with R-flurbiprofen or ibuprofen resulted in a massive induction of p75(NTR) protein levels, the expression of Fas, p55(TNFR), DR3, DR4, DR5, and DR6 remained largely unchanged.	tarenflurbil	23-37	TNF receptor superfamily member 21	Homo sapiens	164-167
17409433-10	2007	Hence, R-flurbiprofen and ibuprofen selectively induce p75(NTR)-dependent decreased survival of prostate cancer cells independently of COX inhibition.	tarenflurbil	7-21	TNF receptor superfamily member 1B	Homo sapiens	55-58
17409433-10	2007	Hence, R-flurbiprofen and ibuprofen selectively induce p75(NTR)-dependent decreased survival of prostate cancer cells independently of COX inhibition.	tarenflurbil	7-21	neurotensin receptor 1	Homo sapiens	59-62
16949054-0	2006	Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase.	tarenflurbil	29-43	thymoma viral proto-oncogene 1	Mus musculus	143-146
16949054-0	2006	Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase.	tarenflurbil	69-83	thymoma viral proto-oncogene 1	Mus musculus	143-146
17650315-0	2007	Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.	tarenflurbil	26-40	amyloid beta (A4) precursor protein	Mus musculus	87-112
17650315-5	2007	In this study we report the effect of chronic R-flurbiprofen treatment on cognition and Abeta loads in Tg2576 APP mice.	tarenflurbil	46-60	amyloid beta (A4) precursor protein	Mus musculus	88-93
17650315-6	2007	RESULTS: A four-month preventative treatment regimen with R-flurbiprofen (10 mg/kg/day) was administered to young Tg2576 mice prior to robust plaque or Abeta pathology.	tarenflurbil	58-72	amyloid beta (A4) precursor protein	Mus musculus	152-157
15946992-9	2005	Celecoxib-induced beta-catenin degradation was also observed in various other tumor cell lines (HCT-116, MCF-7, and LNCAP) but was not seen after treatment of Caco-2 cells with either the anticarcinogenic nonsteroidal anti-inflammatory drug R-flurbiprofen or the highly COX-2-selective inhibitor rofecoxib.	tarenflurbil	241-255	catenin beta 1	Homo sapiens	18-30
15710360-5	2005	Here, we show that treatment of the human colon carcinoma cell line HCT116 with different concentrations of R-flurbiprofen leads to an accumulation of p53 protein which is accompanied by an increase in phosphorylated p53 at serine 15.	tarenflurbil	108-122	tumor protein p53	Homo sapiens	151-154
15710360-5	2005	Here, we show that treatment of the human colon carcinoma cell line HCT116 with different concentrations of R-flurbiprofen leads to an accumulation of p53 protein which is accompanied by an increase in phosphorylated p53 at serine 15.	tarenflurbil	108-122	tumor protein p53	Homo sapiens	217-220
15710360-6	2005	Mutation of serine 15 to alanine by site directed mutagenesis and overexpression of the mutated p53 gene in HCT116 cells, revealed that these cells are significantly less sensitive to apoptosis induced by R-flurbiprofen than pcDNA control cells, as measured by PARP-cleavage and flow cytometry.	tarenflurbil	205-219	tumor protein p53	Homo sapiens	96-99
15710360-9	2005	In conclusion, we were able to show that induction of apoptosis in HCT116 cells after R-flurbiprofen treatment is at least partly dependent on the tumor suppressor gene p53 and that mutation of p53 at serine 15 impairs the apoptotic potency of R-flurbiprofen.	tarenflurbil	86-100	tumor protein p53	Homo sapiens	169-172
15710360-9	2005	In conclusion, we were able to show that induction of apoptosis in HCT116 cells after R-flurbiprofen treatment is at least partly dependent on the tumor suppressor gene p53 and that mutation of p53 at serine 15 impairs the apoptotic potency of R-flurbiprofen.	tarenflurbil	86-100	tumor protein p53	Homo sapiens	194-197
15710360-9	2005	In conclusion, we were able to show that induction of apoptosis in HCT116 cells after R-flurbiprofen treatment is at least partly dependent on the tumor suppressor gene p53 and that mutation of p53 at serine 15 impairs the apoptotic potency of R-flurbiprofen.	tarenflurbil	244-258	tumor protein p53	Homo sapiens	194-197