PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28857290-2	2017	Modification of the first generation cis-amide bioisostere imidazole to alter the angle between the resorcinol ring and the benzyl side chain via cis-amide replacements produced compounds with improved Grp94 affinity and selectivity.	cis-amide	37-46	heat shock protein 90 beta family member 1	Homo sapiens	202-207
9871540-0	1998	Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors.	cis-amide	61-70	coagulation factor II, thrombin	Homo sapiens	95-103
9871540-1	1998	Substituted pyrazoles, 1,2,4-triazoles, and tetrazoles are good surrogates for cis-amide bonds in a series of boronate ester thrombin inhibitors.	cis-amide	79-88	coagulation factor II, thrombin	Homo sapiens	125-133
30258544-1	2018	The X-ray structure of the previously reported PPARdelta modulator 1 bound to the ligand binding domain (LBD) revealed that the amide moiety in 1 exists in the thermodynamically disfavored cis-amide orientation.	cis-amide	189-198	peroxisome proliferator activated receptor delta	Homo sapiens	47-56
28857290-2	2017	Modification of the first generation cis-amide bioisostere imidazole to alter the angle between the resorcinol ring and the benzyl side chain via cis-amide replacements produced compounds with improved Grp94 affinity and selectivity.	cis-amide	146-155	heat shock protein 90 beta family member 1	Homo sapiens	202-207
19435295-0	2009	Design, synthesis, and biological evaluation of conformationally constrained cis-amide Hsp90 inhibitors.	cis-amide	77-86	heat shock protein 90 alpha family class A member 1	Homo sapiens	87-92
27003516-5	2016	Incorporation of a cis-amide bioisostere into the radamide scaffold led to development of the original Grp94-selective inhibitor, BnIm.	cis-amide	19-28	heat shock protein 90 beta family member 1	Homo sapiens	103-108
23511419-5	2013	Protein crystallography established that the new compounds bind to Hsp90 with, as expected, a cis-amide conformation.	cis-amide	94-103	heat shock protein 90 alpha family class A member 1	Homo sapiens	67-72
23223799-5	2013	This allowed us to select for the all cis-amide conformation of the peptide with a pseudo-helical arrangement of extended side chains as a faithful representative structure of [RhoB(Spiro)-Ahx]-[But](6A)NH(2).	cis-amide	38-47	nuclear receptor subfamily 0 group B member 1	Homo sapiens	189-192
19435295-1	2009	Conformationally constrained cis-amide chimeric inhibitors of Hsp90 have been synthesized and evaluated for their Hsp90 inhibitory activity.	cis-amide	29-38	heat shock protein 90 alpha family class A member 1	Homo sapiens	62-67
19435295-1	2009	Conformationally constrained cis-amide chimeric inhibitors of Hsp90 have been synthesized and evaluated for their Hsp90 inhibitory activity.	cis-amide	29-38	heat shock protein 90 alpha family class A member 1	Homo sapiens	114-119
12725864-5	2003	We speculate that 17-DMAG analogs constrained to a cis-amide in the ground state could provide a significant increase in affinity for Hsp90.	cis-amide	51-60	heat shock protein 90 alpha family class A member 1	Homo sapiens	134-139
16754679-5	2006	Evidence for a cis-amide configuration was also observed in the noncovalent complex between elastase and an alpha1-antitrypsin-derived tetrapeptide.	cis-amide	15-24	serpin family A member 1	Homo sapiens	108-126