PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21289522-1	2011	BACKGROUND: AT-101 is an inhibitor of Bcl-2 family proteins including Bcl-2, Bcl-xL, Mcl-1, and Bcl-w.	gossypol acetic acid	12-18	BCL2 apoptosis regulator	Homo sapiens	38-43
22112969-0	2012	Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer.	gossypol acetic acid	86-92	BCL2 apoptosis regulator	Homo sapiens	117-122
22112969-1	2012	BACKGROUND: AT-101 (A), a small molecule oral inhibitor of the Bcl-2 family, has activity alone and in combination with docetaxel (Taxotere) and prednisone (DP) in metastatic castration-resistant prostate cancer (mCRPC).	gossypol acetic acid	12-18	BCL2 apoptosis regulator	Homo sapiens	63-68
22411600-0	2012	Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels.	gossypol acetic acid	18-24	TNF superfamily member 10	Homo sapiens	34-89
22411600-0	2012	Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels.	gossypol acetic acid	18-24	TNF superfamily member 10	Homo sapiens	91-96
22411600-2	2012	AT-101, an (-)-enantiomer of gossypol, is a potent anticancer agent that is shown to be an inhibitor of Bcl-2/Bcl-XL.	gossypol acetic acid	0-6	BCL2 apoptosis regulator	Homo sapiens	104-109
22411600-2	2012	AT-101, an (-)-enantiomer of gossypol, is a potent anticancer agent that is shown to be an inhibitor of Bcl-2/Bcl-XL.	gossypol acetic acid	0-6	BCL2 like 1	Homo sapiens	110-116
22411600-11	2012	CONCLUSIONS: These findings all together, strongly suggest that pretreatment with AT-101 enhances TRAIL-induced death-inducing signaling complex resulting in the engagement of the mitochondrial pathway to apoptosis in breast cancer cells.	gossypol acetic acid	82-88	TNF superfamily member 10	Homo sapiens	98-103
22171982-0	2012	Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner.	gossypol acetic acid	26-32	BCL2 apoptosis regulator	Homo sapiens	18-22
22171982-7	2012	This effect was further enhanced with pre-treatment of tumour cells with AT-101 (a BH3 mimetic that functions as BCL2 antagonist).	gossypol acetic acid	73-79	BCL2 apoptosis regulator	Homo sapiens	113-117
23185240-0	2012	Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells.	gossypol acetic acid	20-26	BCL2 apoptosis regulator	Homo sapiens	4-9
23185240-0	2012	Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells.	gossypol acetic acid	20-26	epidermal growth factor receptor	Homo sapiens	58-62
23185240-5	2012	We found that pretreatment of tumor cells with AT-101 enhanced susceptibility of L3.6pl and MiaPaCa-2 tumor cells to ATC and aATC-mediated cytotoxicity, which was in part mediated via enhanced release of cytolytic granule GrzB from ATC and aATC.	gossypol acetic acid	47-53	granzyme B	Homo sapiens	222-226
23185240-7	2012	Priming (conditioning) of PC cells with AT-101 can significantly enhance the anti-tumor activity of EGFRBi armed ATC through increased IFN-gamma induced activation of pS(727)-Stat1 and inhibition of pY(705)-Stat3 phosphorylation, and resulting in increased ratio of pro-apoptotic to anti-apoptotic proteins.	gossypol acetic acid	40-46	interferon gamma	Homo sapiens	135-144
23185240-7	2012	Priming (conditioning) of PC cells with AT-101 can significantly enhance the anti-tumor activity of EGFRBi armed ATC through increased IFN-gamma induced activation of pS(727)-Stat1 and inhibition of pY(705)-Stat3 phosphorylation, and resulting in increased ratio of pro-apoptotic to anti-apoptotic proteins.	gossypol acetic acid	40-46	signal transducer and activator of transcription 1	Homo sapiens	175-180
21505732-0	2011	[Gossypol acetic acid induces DNA double-strand breaks in human mucoepidermoid carcinoma cell MEC-1].	gossypol acetic acid	1-21	ATR serine/threonine kinase	Homo sapiens	94-99
21505732-1	2011	The present study was conducted to investigate the effects of gossypol acetic acid (GAA) on the proliferation of human mucoepidermoid carcinoma cell line MEC-1 in vitro and its possible molecular mechanisms of DNA double-strand breaks (DSB).	gossypol acetic acid	62-82	alpha glucosidase	Homo sapiens	84-87
21505732-1	2011	The present study was conducted to investigate the effects of gossypol acetic acid (GAA) on the proliferation of human mucoepidermoid carcinoma cell line MEC-1 in vitro and its possible molecular mechanisms of DNA double-strand breaks (DSB).	gossypol acetic acid	62-82	ATR serine/threonine kinase	Homo sapiens	154-159
21289522-1	2011	BACKGROUND: AT-101 is an inhibitor of Bcl-2 family proteins including Bcl-2, Bcl-xL, Mcl-1, and Bcl-w.	gossypol acetic acid	12-18	BCL2 apoptosis regulator	Homo sapiens	70-75
21289522-1	2011	BACKGROUND: AT-101 is an inhibitor of Bcl-2 family proteins including Bcl-2, Bcl-xL, Mcl-1, and Bcl-w.	gossypol acetic acid	12-18	BCL2 like 1	Homo sapiens	77-83
21289522-1	2011	BACKGROUND: AT-101 is an inhibitor of Bcl-2 family proteins including Bcl-2, Bcl-xL, Mcl-1, and Bcl-w.	gossypol acetic acid	12-18	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	85-90
21289522-1	2011	BACKGROUND: AT-101 is an inhibitor of Bcl-2 family proteins including Bcl-2, Bcl-xL, Mcl-1, and Bcl-w.	gossypol acetic acid	12-18	BCL2 like 2	Homo sapiens	96-101
21289522-19	2011	AT-101 is the first oral, pan Bcl-2 family inhibitor to exhibit a possible survival benefit in a randomized study.	gossypol acetic acid	0-6	BCL2 apoptosis regulator	Homo sapiens	30-35
21357440-7	2011	TRA-8 combined with AT-101 or BH3I-2", inhibitors of antiapoptotic Bcl-2 proteins, produced synergistic cytotoxicity against ZR-75-1, BT-474, and T47D cells.	gossypol acetic acid	20-26	BCL2 apoptosis regulator	Homo sapiens	67-72
20832445-1	2010	Gossypol acetic acid (GAA) displays anti-fertility and antioxidant behavior.	gossypol acetic acid	0-20	alpha glucosidase	Rattus norvegicus	22-25
20808253-1	2010	INTRODUCTION: AT-101 is an oral, pan Bcl-2 family protein inhibitor that has demonstrated activity in small cell lung cancer (SCLC) models.	gossypol acetic acid	14-20	BCL2 apoptosis regulator	Homo sapiens	37-42
20589722-8	2010	VCaP cells treated with AT-101 demonstrated an increase in apoptosis and downregulation of Bcl-2 pro-survival proteins.	gossypol acetic acid	24-30	BCL2 apoptosis regulator	Homo sapiens	91-96
19556859-11	2009	AT-101, which also neutralizes Mcl1, had single-agent cytotoxicity, further augmented by Mcl1 knockdown.	gossypol acetic acid	0-6	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	31-35
20354451-0	2010	AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer.	gossypol acetic acid	0-6	BCL2 apoptosis regulator	Homo sapiens	14-19
20030926-6	2009	At the same time, gossypol acetic acid could also down-regulate the mitochondrial membrane potential, up-regulate the expression of the apoptosis-related protein such as BAX and caspase-3.	gossypol acetic acid	18-38	BCL2 associated X, apoptosis regulator	Homo sapiens	170-173
20030926-6	2009	At the same time, gossypol acetic acid could also down-regulate the mitochondrial membrane potential, up-regulate the expression of the apoptosis-related protein such as BAX and caspase-3.	gossypol acetic acid	18-38	caspase 3	Homo sapiens	178-187
19852810-0	2009	AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis.	gossypol acetic acid	0-6	BCL2 apoptosis regulator	Homo sapiens	53-58
19852810-0	2009	AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis.	gossypol acetic acid	0-6	mitogen-activated protein kinase 9	Homo sapiens	89-93
19852810-0	2009	AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis.	gossypol acetic acid	0-6	mitogen-activated protein kinase 9	Homo sapiens	94-97
19852810-10	2009	Like radiation, AT-101 activated SAPK/JNK which was blocked by the kinase inhibitor SP600125.	gossypol acetic acid	16-22	mitogen-activated protein kinase 9	Homo sapiens	33-37
19852810-10	2009	Like radiation, AT-101 activated SAPK/JNK which was blocked by the kinase inhibitor SP600125.	gossypol acetic acid	16-22	mitogen-activated protein kinase 9	Homo sapiens	38-41
19852810-12	2009	CONCLUSION: Our data show that AT-101 strongly enhances radiation-induced apoptosis in human leukemic cells and indicate a requirement for the SAPK/JNK pathway in AT-101-induced apoptosis.	gossypol acetic acid	163-169	mitogen-activated protein kinase 9	Homo sapiens	143-147
19852810-12	2009	CONCLUSION: Our data show that AT-101 strongly enhances radiation-induced apoptosis in human leukemic cells and indicate a requirement for the SAPK/JNK pathway in AT-101-induced apoptosis.	gossypol acetic acid	163-169	mitogen-activated protein kinase 9	Homo sapiens	148-151
19556859-11	2009	AT-101, which also neutralizes Mcl1, had single-agent cytotoxicity, further augmented by Mcl1 knockdown.	gossypol acetic acid	0-6	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	89-93
17597109-9	2007	Furthermore, an intraperitoneal injection of GOS or gossypol acetic acid (GAA) significantly reduced the growth of colorectal carcinoma induced by a subcutaneous injection of COLO205 cells in nude mice.	gossypol acetic acid	52-72	alpha glucosidase	Homo sapiens	74-77
18836097-0	2009	AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance.	gossypol acetic acid	0-6	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	76-81
18836097-3	2009	Because AT-101 binds to the BH3 motif of all Bcl-2-family antiapoptotic proteins, we hypothesized that this molecule could overcome resistance.	gossypol acetic acid	8-14	BCL2 apoptosis regulator	Homo sapiens	45-50
18836097-6	2009	However, AT-101 induced similar extent of down-regulation of Mcl-1 and apoptosis in CLL lymphocytes cultured in suspension or on stroma (P = .999).	gossypol acetic acid	9-15	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	61-66
18346839-2	2008	R-(-)-gossypol (AT-101) is a small molecule that mimics the BH3 domain of cellular Bcl-2 inhibitors and interferes with the function of prosurvival Bcl-2 proteins.	gossypol acetic acid	16-22	BCL2 apoptosis regulator	Homo sapiens	83-88
18346839-2	2008	R-(-)-gossypol (AT-101) is a small molecule that mimics the BH3 domain of cellular Bcl-2 inhibitors and interferes with the function of prosurvival Bcl-2 proteins.	gossypol acetic acid	16-22	BCL2 apoptosis regulator	Homo sapiens	148-153
18346839-8	2008	Apoptosis was activated via the mitochondrial pathway in multiple myeloma cell lines treated with AT-101 as demonstrated by an increased Bax to Bcl-2 ratio, mitochondrial membrane depolarization, and caspase activation.	gossypol acetic acid	98-104	BCL2 associated X, apoptosis regulator	Homo sapiens	137-140
18346839-8	2008	Apoptosis was activated via the mitochondrial pathway in multiple myeloma cell lines treated with AT-101 as demonstrated by an increased Bax to Bcl-2 ratio, mitochondrial membrane depolarization, and caspase activation.	gossypol acetic acid	98-104	BCL2 apoptosis regulator	Homo sapiens	144-149
18292288-3	2008	AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members including Bcl-2, Bcl-X(L), and Mcl-1.	gossypol acetic acid	0-6	B cell leukemia/lymphoma 2	Mus musculus	72-77
18292288-3	2008	AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members including Bcl-2, Bcl-X(L), and Mcl-1.	gossypol acetic acid	0-6	B cell leukemia/lymphoma 2	Mus musculus	103-108
18292288-3	2008	AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members including Bcl-2, Bcl-X(L), and Mcl-1.	gossypol acetic acid	0-6	BCL2-like 1	Mus musculus	110-118
18292288-3	2008	AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members including Bcl-2, Bcl-X(L), and Mcl-1.	gossypol acetic acid	0-6	myeloid cell leukemia sequence 1	Mus musculus	124-129
18084610-4	2007	Here, we investigated the efficacy of AT-101 (R-(-)-gossypol acetic acid; a pan small molecule inhibitor of Bcl-2, Bcl-x(L), and Mcl-1) in combination with surgical castration to delay the onset of androgen-independent growth in vivo.	gossypol acetic acid	46-72	BCL2 apoptosis regulator	Homo sapiens	108-113
18084610-4	2007	Here, we investigated the efficacy of AT-101 (R-(-)-gossypol acetic acid; a pan small molecule inhibitor of Bcl-2, Bcl-x(L), and Mcl-1) in combination with surgical castration to delay the onset of androgen-independent growth in vivo.	gossypol acetic acid	46-72	BCL2 like 1	Homo sapiens	115-120
18084610-4	2007	Here, we investigated the efficacy of AT-101 (R-(-)-gossypol acetic acid; a pan small molecule inhibitor of Bcl-2, Bcl-x(L), and Mcl-1) in combination with surgical castration to delay the onset of androgen-independent growth in vivo.	gossypol acetic acid	46-72	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	129-134
18084610-8	2007	CONCLUSIONS: We conclude that AT-101 in combination with surgical castration delays the onset of androgen-independent prostate cancer in vivo by disrupting the antiapoptotic activity of Bcl-2 upregulation during the transition to androgen independence.	gossypol acetic acid	30-36	BCL2 apoptosis regulator	Homo sapiens	186-191
10231019-1	1999	Gossypol acetic acid (GAA) has been shown to have male antifertility effects, but there are pronounced differences among animal species.	gossypol acetic acid	0-20	alpha glucosidase	Homo sapiens	22-25
9879931-0	1998	Induction of c-fos, and cytochrome c oxidase subunits I and II by gossypol acetic acid in rat liver cells.	gossypol acetic acid	66-86	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-18
9879931-0	1998	Induction of c-fos, and cytochrome c oxidase subunits I and II by gossypol acetic acid in rat liver cells.	gossypol acetic acid	66-86	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	24-62
9408707-1	1997	In our earlier study, we have observed that hypokalemia in langur monkeys, following gossypol acetic acid (GAA) treatment (5 mg dose level) when used as an antispermatogenic agent, and potassium salt supplementation partially maintained body potassium level of the animals.	gossypol acetic acid	85-105	alpha glucosidase	Homo sapiens	107-110
8000225-2	1994	The binding capacity of cytosolic estradiol receptor (E2R) and progesterone receptor (PR) in groups treated with gossypol acetate or progesterone decreased.	gossypol acetic acid	113-129	progesterone receptor	Homo sapiens	63-84
8835944-2	1996	Platinum compounds inhibited the enzyme in the forward reaction (pyruvate-->lactate) only, n-hexanediol and colchicine showed no inhibition and gossypol acetic acid (GAA) strongly inhibited both the forward and reverse reactions and the reactions were time-dependent.	gossypol acetic acid	147-167	alpha glucosidase	Homo sapiens	169-172
8000225-2	1994	The binding capacity of cytosolic estradiol receptor (E2R) and progesterone receptor (PR) in groups treated with gossypol acetate or progesterone decreased.	gossypol acetic acid	113-129	progesterone receptor	Homo sapiens	86-88
3340619-1	1988	Carbon disulfide (CS2), tetraethyl lead (TEL), tetraethyl tin (TeET), dithiothreitol (DTT), and gossypol acetic acid (GAA) significantly decreased brain norepinephrine (NE) in rats.	gossypol acetic acid	96-116	alpha glucosidase	Rattus norvegicus	118-121
2063399-2	1991	The control group (n = 5) were injected with vehicle intramuscularly on the 17th, 18th and 19th day of pregnancy, and the gossypol treated group (n = 4) were injected with gossypol acetic acid (GAA) (25 mg/kg of body weight) intramuscularly on the 17th, 18th and 19th day and were decapitated on the 20th day of pregnancy.	gossypol acetic acid	172-192	alpha glucosidase	Rattus norvegicus	194-197
3402348-1	1988	Gossypol-acetic acid (GAA) has been shown to be a powerful chelator of iron.	gossypol acetic acid	0-20	alpha glucosidase	Rattus norvegicus	22-25
2975138-0	1988	[Effects of gossypol acetic acid on heart mitochondrial membranes ATPase].	gossypol acetic acid	12-32	dynein axonemal heavy chain 8	Homo sapiens	66-72
1668561-0	1991	[Effect of gossypol acetic acid on hCG-stimulated progesterone production of dissociated rat luteal cells].	gossypol acetic acid	11-31	hypertrichosis 2 (generalised, congenital)	Homo sapiens	35-38
1668561-1	1991	The effect of gossypol acetic acid on hCG-stimulated progesterone synthesis and secretion in isolated rat luteal cells and its possible mechanism were investigated.	gossypol acetic acid	14-34	hypertrichosis 2 (generalised, congenital)	Homo sapiens	38-41
1668561-6	1991	The present experiment indicates that gossypol acetic acid can inhibit the progesterone production stimulated by hCG in isolated rat luteal cells through direct cellular mechanism.	gossypol acetic acid	38-58	hypertrichosis 2 (generalised, congenital)	Homo sapiens	113-116
2083490-4	1990	Subcutaneous administration in both low (15 mg/kg) and high (30 mg/kg) doses of gossypol acetic acid for five consecutive days significantly (P less than 0.00001) reduced hepatic aniline hydroxylase activity, as well as cytochrome P-450 and b5 levels.	gossypol acetic acid	80-100	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	220-243
34827665-2	2021	Gossypol acetic acid (GAA), a natural product taken from the seeds of cotton plants, prevents oxidative stress.	gossypol acetic acid	0-20	alpha glucosidase	Rattus norvegicus	22-25
35484333-8	2022	Most importantly, gossypol-acetic acid (GAA) was recently reported by our team as the first specific inhibitor of LRPPRC.	gossypol acetic acid	18-38	alpha glucosidase	Homo sapiens	40-43
35484333-8	2022	Most importantly, gossypol-acetic acid (GAA) was recently reported by our team as the first specific inhibitor of LRPPRC.	gossypol acetic acid	18-38	leucine rich pentatricopeptide repeat containing	Homo sapiens	114-120
3190716-0	1988	Inhibition kinetics of lactate dehydrogenase isoenzymes by gossypol acetic acid.	gossypol acetic acid	59-79	lactate dehydrogenase	Capra hircus	23-44
3447817-1	1987	The studies in this report evaluate the inhibitory effects of long-term gossypol acetic acid (gossypol) administration on spermatozoal lactate dehydrogenase (LDH-X) activity, fertility and reversibility.	gossypol acetic acid	72-92	lactate dehydrogenase C	Rattus norvegicus	158-163
3626595-1	1987	Gossypol acetic acid (GAA) at the dosage of 30 mg/kg daily for 2 weeks could prolong the sleeping time of pentobarbital, increase the SGPT level, decrease the liver concentration of cytochrome P-450 and GSH content, inhibit the activity of cytochrome C reductase and aminopyrine-N-demethylase, but was without effect on cytochrome b5 and aniline hydroxylase.	gossypol acetic acid	0-20	alpha glucosidase	Rattus norvegicus	22-25
3625427-2	1987	Gossypol acetic acid (GAA), fed to juvenile chickens from 1 to 35 days, caused a decreased weight gain when compared to controls on untreated feed.	gossypol acetic acid	0-20	alpha glucosidase 2	Gallus gallus	22-25
3626595-1	1987	Gossypol acetic acid (GAA) at the dosage of 30 mg/kg daily for 2 weeks could prolong the sleeping time of pentobarbital, increase the SGPT level, decrease the liver concentration of cytochrome P-450 and GSH content, inhibit the activity of cytochrome C reductase and aminopyrine-N-demethylase, but was without effect on cytochrome b5 and aniline hydroxylase.	gossypol acetic acid	0-20	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	182-206
3626595-1	1987	Gossypol acetic acid (GAA) at the dosage of 30 mg/kg daily for 2 weeks could prolong the sleeping time of pentobarbital, increase the SGPT level, decrease the liver concentration of cytochrome P-450 and GSH content, inhibit the activity of cytochrome C reductase and aminopyrine-N-demethylase, but was without effect on cytochrome b5 and aniline hydroxylase.	gossypol acetic acid	0-20	cytochrome b5 type A	Rattus norvegicus	320-333
6454365-2	1981	Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa.	gossypol acetic acid	10-30	dynein axonemal heavy chain 8	Homo sapiens	51-57
2939980-0	1985	[Synergic effects of gossypol acetate and sulphadiazine on the LDH-x activity and viability of human sperm].	gossypol acetic acid	21-37	lactate dehydrogenase C	Homo sapiens	63-68
6421193-1	1983	Male adult Wistar rats were exposed daily or every other day to oral gossypol acetic acid (GAA) concentrations of 2.5-30 mg/kg for 10-20 weeks.	gossypol acetic acid	69-89	alpha glucosidase	Rattus norvegicus	91-94
7114507-1	1982	Fertility response and sperm motility of male Wistar rats exposed to various concentrations (2.5 - 30 mg / kg / day) of gossypol acetic acid (GAA) was studied.	gossypol acetic acid	120-140	alpha glucosidase	Rattus norvegicus	142-145
3568662-1	1987	Gossypol acetic acid could induce total infertility in male Wistar/NIN strain rats at a dose of 30 mg per kg body weight per day, for 52 days.	gossypol acetic acid	0-20	ninein	Rattus norvegicus	67-70
3735252-1	1986	The inhibitory effect of (+)-, (-)-, (+/-)-gossypol and (+/-)-gossypol acetic acid upon testicular cytosolic LDH-X was measured in vitro.	gossypol acetic acid	56-82	lactate dehydrogenase C	Homo sapiens	109-114
3735252-2	1986	Gossypol acetic acid (0-100 mumol/l) inhibited LDH-X prepared from the testes of the mouse greater than rabbit greater than human greater than rat greater than hamster.	gossypol acetic acid	0-20	lactate dehydrogenase C	Mus musculus	47-52
6868221-0	1983	Ultrastructural analysis of rat testes after gossypol acetic acid (GAA) treatment.	gossypol acetic acid	45-65	alpha glucosidase	Rattus norvegicus	67-70
7160182-3	1982	Varying concentrations of gossypol acetic acid were incubated with 3H-methyl-S-adenosyl-methionine, COMT, a different concentrations of norepinephrine.	gossypol acetic acid	26-46	catechol-O-methyltransferase	Rattus norvegicus	100-104
31264066-0	2020	In vivo and in vitro inhibition of osteosarcoma growth by the pan Bcl-2 inhibitor AT-101.	gossypol acetic acid	82-88	BCL2 apoptosis regulator	Homo sapiens	66-71
32982170-3	2020	Gossypol-acetic acid (GAA) is a male contraceptive agent that shows anti-tumor effects on multiple types of cancers.	gossypol acetic acid	0-20	alpha glucosidase	Homo sapiens	22-25
33495516-6	2021	Gossypol acetate dose-dependently inhibited the enzymatic activity of VCP in vitro with IC50 of 6.53+-0.6 muM.	gossypol acetic acid	0-16	valosin containing protein	Homo sapiens	70-73
33495516-9	2021	Taken together, gossypol acetate acted through a gain-of-function way to induce the formation of VCP-LC3-mHTT ternary complex, triggering autophagic degradation of mHTT.	gossypol acetic acid	16-32	valosin containing protein	Mus musculus	97-100
33495516-9	2021	Taken together, gossypol acetate acted through a gain-of-function way to induce the formation of VCP-LC3-mHTT ternary complex, triggering autophagic degradation of mHTT.	gossypol acetic acid	16-32	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	101-104
33487592-3	2021	We sought to elucidate the antitumour action of a BCL-2 inhibitor, AT101 in GEC in vitro, in vivo and in a clinical trial.	gossypol acetic acid	67-72	BCL2 apoptosis regulator	Homo sapiens	50-55
33487592-7	2021	AT-101 induced apoptosis, reduced proliferation and tumour sphere formation in MCL-1/BCL-2 high GC cells.	gossypol acetic acid	0-6	BCL2 apoptosis regulator	Homo sapiens	85-90
33487592-10	2021	In vivo studies confirmed the combination of AT101 and docetaxel demonstrated stronger antitumour activity accompanied with significant decrease of CSCs biomarkers (YAP1/SOX9).	gossypol acetic acid	45-50	Yes1 associated transcriptional regulator	Homo sapiens	165-169
33487592-10	2021	In vivo studies confirmed the combination of AT101 and docetaxel demonstrated stronger antitumour activity accompanied with significant decrease of CSCs biomarkers (YAP1/SOX9).	gossypol acetic acid	45-50	SRY-box transcription factor 9	Homo sapiens	170-174
31264066-10	2020	Our results demonstrated that AT-101 inhibits prosurvival signaling pathways depending on Akt, p38 MAPK and JNK.	gossypol acetic acid	30-36	AKT serine/threonine kinase 1	Homo sapiens	90-93
31264066-10	2020	Our results demonstrated that AT-101 inhibits prosurvival signaling pathways depending on Akt, p38 MAPK and JNK.	gossypol acetic acid	30-36	mitogen-activated protein kinase 14	Homo sapiens	95-98
31264066-10	2020	Our results demonstrated that AT-101 inhibits prosurvival signaling pathways depending on Akt, p38 MAPK and JNK.	gossypol acetic acid	30-36	mitogen-activated protein kinase 8	Homo sapiens	108-111
31388792-2	2020	This phase I trial investigated the MTD of AT-101 in combination with paclitaxel and carboplatin in patients with advanced solid tumors.	gossypol acetic acid	43-49	metallothionein 1E	Homo sapiens	36-39
31657561-7	2019	The screened compound, gossypol-acetic acid (GAA), is an old medicine which can accomplish the new function for targeted LRPPRC knockdown.	gossypol acetic acid	23-43	leucine rich pentatricopeptide repeat containing	Homo sapiens	121-127
31657561-7	2019	The screened compound, gossypol-acetic acid (GAA), is an old medicine which can accomplish the new function for targeted LRPPRC knockdown.	gossypol acetic acid	45-48	leucine rich pentatricopeptide repeat containing	Homo sapiens	121-127
30605780-4	2019	The present study investigated the inhibitory effects of gossypol acetate on rat 5alpha-reductase 1, 3alpha-hydroxysteroid dehydrogenase, and retinol dehydrogenase 2 for androgen metabolism.	gossypol acetic acid	57-73	aldo-keto reductase family 1, member C14	Rattus norvegicus	101-136
30605780-9	2019	Gossypol acetate inhibited 5alpha-reductase 1 and 3alpha-hydroxysteroid dehydrogenase with IC50 values of 3.33 +- 0.07 and 0.52 +- 0.06 x 10-6 M in the expressed enzymes as well as 8.512 +- 0.079 and 1.032 +- 0.068 x 10-6 M in intact rat immature Leydig cells, respectively.	gossypol acetic acid	0-16	aldo-keto reductase family 1, member C14	Rattus norvegicus	50-85
30605780-11	2019	Gossypol acetate weakly inhibited retinol dehydrogenase 2 with IC50 value over 1 x 10-4 M. Molecular docking analysis showed that gossypol partially bound to the steroid-binding site of the crystal structure of rat 3alpha-hydroxysteroid dehydrogenase.	gossypol acetic acid	0-16	retinol dehydrogenase 16	Rattus norvegicus	34-57
30605780-11	2019	Gossypol acetate weakly inhibited retinol dehydrogenase 2 with IC50 value over 1 x 10-4 M. Molecular docking analysis showed that gossypol partially bound to the steroid-binding site of the crystal structure of rat 3alpha-hydroxysteroid dehydrogenase.	gossypol acetic acid	0-16	aldo-keto reductase family 1, member C14	Rattus norvegicus	215-250
30605780-12	2019	Gossypol acetate is a potent inhibitor of rat 5alpha-reductase 1 and 3alpha-hydroxysteroid dehydrogenase, possibly inhibiting the formation of androgen in the prostate cancer cells.	gossypol acetic acid	0-16	aldo-keto reductase family 1, member C14	Rattus norvegicus	69-104
27431492-4	2016	In this study, enhanced antitumor effect of AT-101, a-pan-Bcl-2 inhibitor, on gefitinib was explored in NSCLC with T790M mutation.	gossypol acetic acid	44-50	BCL2 apoptosis regulator	Homo sapiens	58-63
30483745-0	2019	AT-101 induces G1/G0 phase arrest via the beta-catenin/cyclin D1 signaling pathway in human esophageal cancer cells.	gossypol acetic acid	0-6	catenin beta 1	Homo sapiens	42-54
30483745-0	2019	AT-101 induces G1/G0 phase arrest via the beta-catenin/cyclin D1 signaling pathway in human esophageal cancer cells.	gossypol acetic acid	0-6	cyclin D1	Homo sapiens	55-64
30483745-1	2019	AT-101, an orally available and well-tolerated natural pan-Bcl-2 family protein inhibitor, has been reported to be effective against a variety of cancers.	gossypol acetic acid	0-6	BCL2 apoptosis regulator	Homo sapiens	59-64
28710745-0	2017	The pan-Bcl2 Inhibitor AT101 Activates the Intrinsic Apoptotic Pathway and Causes DNA Damage in Acute Myeloid Leukemia Stem-Like Cells.	gossypol acetic acid	23-28	BCL2 apoptosis regulator	Homo sapiens	8-12
28575052-8	2017	Treatment of hiPSC precursors with autophagy stimulators Rapamycin, Perifosine, or AT101 showed reduction in VCP pathology markers TDP-43, LC3-I/II and p62/SQSTM1.	gossypol acetic acid	83-88	valosin containing protein	Homo sapiens	109-112
28575052-8	2017	Treatment of hiPSC precursors with autophagy stimulators Rapamycin, Perifosine, or AT101 showed reduction in VCP pathology markers TDP-43, LC3-I/II and p62/SQSTM1.	gossypol acetic acid	83-88	TAR DNA binding protein	Homo sapiens	131-137
28575052-8	2017	Treatment of hiPSC precursors with autophagy stimulators Rapamycin, Perifosine, or AT101 showed reduction in VCP pathology markers TDP-43, LC3-I/II and p62/SQSTM1.	gossypol acetic acid	83-88	sequestosome 1	Homo sapiens	152-155
28575052-8	2017	Treatment of hiPSC precursors with autophagy stimulators Rapamycin, Perifosine, or AT101 showed reduction in VCP pathology markers TDP-43, LC3-I/II and p62/SQSTM1.	gossypol acetic acid	83-88	sequestosome 1	Homo sapiens	156-162
30459622-12	2018	In addition, the treatment with AT-101 was able to: (a) decrease the ErbB2 protein expression; (b) increase the EGFR protein expression; (c) affect the phosphorylation of ERK1/2, p38 and AKT; (d) stimulate JNK1/2 and c-jun phosphorylation.	gossypol acetic acid	32-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	69-74
30459622-12	2018	In addition, the treatment with AT-101 was able to: (a) decrease the ErbB2 protein expression; (b) increase the EGFR protein expression; (c) affect the phosphorylation of ERK1/2, p38 and AKT; (d) stimulate JNK1/2 and c-jun phosphorylation.	gossypol acetic acid	32-38	epidermal growth factor receptor	Homo sapiens	112-116
30459622-12	2018	In addition, the treatment with AT-101 was able to: (a) decrease the ErbB2 protein expression; (b) increase the EGFR protein expression; (c) affect the phosphorylation of ERK1/2, p38 and AKT; (d) stimulate JNK1/2 and c-jun phosphorylation.	gossypol acetic acid	32-38	mitogen-activated protein kinase 3	Homo sapiens	171-177
30459622-12	2018	In addition, the treatment with AT-101 was able to: (a) decrease the ErbB2 protein expression; (b) increase the EGFR protein expression; (c) affect the phosphorylation of ERK1/2, p38 and AKT; (d) stimulate JNK1/2 and c-jun phosphorylation.	gossypol acetic acid	32-38	mitogen-activated protein kinase 1	Homo sapiens	179-182
30459622-12	2018	In addition, the treatment with AT-101 was able to: (a) decrease the ErbB2 protein expression; (b) increase the EGFR protein expression; (c) affect the phosphorylation of ERK1/2, p38 and AKT; (d) stimulate JNK1/2 and c-jun phosphorylation.	gossypol acetic acid	32-38	AKT serine/threonine kinase 1	Homo sapiens	187-190
30459622-12	2018	In addition, the treatment with AT-101 was able to: (a) decrease the ErbB2 protein expression; (b) increase the EGFR protein expression; (c) affect the phosphorylation of ERK1/2, p38 and AKT; (d) stimulate JNK1/2 and c-jun phosphorylation.	gossypol acetic acid	32-38	mitogen-activated protein kinase 8	Homo sapiens	206-212
30459622-12	2018	In addition, the treatment with AT-101 was able to: (a) decrease the ErbB2 protein expression; (b) increase the EGFR protein expression; (c) affect the phosphorylation of ERK1/2, p38 and AKT; (d) stimulate JNK1/2 and c-jun phosphorylation.	gossypol acetic acid	32-38	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	217-222
27431492-9	2016	RESULTS: In this study, we found that treatment with AT-101 in combination with gefitinib significantly inhibited cell proliferation, as well as promoted apoptosis of EGFR TKIs resistant lung cancer cells.	gossypol acetic acid	53-59	epidermal growth factor receptor	Homo sapiens	167-171
27431492-10	2016	The apoptotic effects of the use of AT-101 was related to the blocking of antiapoptotic protein: Bcl-2, Bcl-xl, and Mcl-1 and downregrulation of the molecules in EGFR pathway.	gossypol acetic acid	36-42	BCL2 apoptosis regulator	Homo sapiens	97-102
27431492-10	2016	The apoptotic effects of the use of AT-101 was related to the blocking of antiapoptotic protein: Bcl-2, Bcl-xl, and Mcl-1 and downregrulation of the molecules in EGFR pathway.	gossypol acetic acid	36-42	BCL2 like 1	Homo sapiens	104-110
27431492-10	2016	The apoptotic effects of the use of AT-101 was related to the blocking of antiapoptotic protein: Bcl-2, Bcl-xl, and Mcl-1 and downregrulation of the molecules in EGFR pathway.	gossypol acetic acid	36-42	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	116-121
27431492-10	2016	The apoptotic effects of the use of AT-101 was related to the blocking of antiapoptotic protein: Bcl-2, Bcl-xl, and Mcl-1 and downregrulation of the molecules in EGFR pathway.	gossypol acetic acid	36-42	epidermal growth factor receptor	Homo sapiens	162-166
27431492-13	2016	The addition of AT-101 to gefitinib is a promising strategy to overcome EGFR TKIs resistance in NSCLC with EGFR T790M mutations.	gossypol acetic acid	16-22	epidermal growth factor receptor	Homo sapiens	72-76
27431492-13	2016	The addition of AT-101 to gefitinib is a promising strategy to overcome EGFR TKIs resistance in NSCLC with EGFR T790M mutations.	gossypol acetic acid	16-22	epidermal growth factor receptor	Homo sapiens	107-111
26721623-5	2016	AT-101 treatment induced a prominent conversion of LC3-I to LC3-II and apoptotic cell death characterized by the appearance of Annexin-positive/PI-negative early apoptotic cells and PARP cleavage.	gossypol acetic acid	0-6	collagen type XI alpha 2 chain	Homo sapiens	182-186
26531719-0	2016	Octreotide in combination with AT-101 induces cytotoxicity and apoptosis through up-regulation of somatostatin receptors 2 and 5 in DU-145 prostate cancer cells.	gossypol acetic acid	31-37	somatostatin receptor 2	Homo sapiens	98-128
26476589-0	2016	A Phase II Study of AT-101 to Overcome Bcl-2--Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer.	gossypol acetic acid	20-26	BCL2 apoptosis regulator	Homo sapiens	39-44
26476589-1	2016	UNLABELLED: In a phase II multicenter study, men with castration sensitive metastatic prostate cancer were treated with AT-101, a small molecule Bcl-2 inhibitor, and androgen deprivation therapy.	gossypol acetic acid	120-126	BCL2 apoptosis regulator	Homo sapiens	145-150
26309203-0	2015	Gossypol acetate induced apoptosis of pituitary tumor cells by targeting the BCL-2 via the upregulated microRNA miR-15a.	gossypol acetic acid	0-16	BCL2, apoptosis regulator	Rattus norvegicus	77-82
26535659-1	2015	We investigated the effects of gossypol acetic acid (GAA) on the proliferation, apoptosis, and expression of DNA methyltransferase 1 (DNMT1) mRNA in human adenoid cystic carcinoma (ACC-M) cells in vitro.	gossypol acetic acid	31-51	DNA methyltransferase 1	Homo sapiens	109-132
26223311-0	2015	Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer.	gossypol acetic acid	34-40	BCL2 apoptosis regulator	Homo sapiens	25-30
26223311-5	2015	The aim of this study was to evaluate combined effects of radiation and the pan-Bcl-2 inhibitor AT-101 in HNSCC in vitro.	gossypol acetic acid	96-102	BCL2 apoptosis regulator	Homo sapiens	80-85
26309203-0	2015	Gossypol acetate induced apoptosis of pituitary tumor cells by targeting the BCL-2 via the upregulated microRNA miR-15a.	gossypol acetic acid	0-16	microRNA mir-15a	Rattus norvegicus	112-119
26089640-6	2015	AT-101 also enhanced the inhibitory effect of CDDP on DNA repair and redox activities of apurinic/apyrimidinic endonuclease 1 (APE1) in A549 cells.	gossypol acetic acid	0-6	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	127-131
26089640-8	2015	These results suggest that AT-101 can enhance the antitumor activity of CDDP in NSCLC via inhibition of APE1 DNA repair and redox activities and by angiogenesis and induction of apoptosis, but other mechanisms cannot be excluded.	gossypol acetic acid	27-33	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	104-108
26089640-0	2015	Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer.	gossypol acetic acid	51-57	BCL2 apoptosis regulator	Homo sapiens	35-40
25548514-0	2014	Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.	gossypol acetic acid	26-32	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	133-169
26089640-0	2015	Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer.	gossypol acetic acid	51-57	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	125-129
26089640-1	2015	AT-101 is a BH3 mimetic and pan-Bcl-2 inhibitor that has shown potent anticancer activity in non-small-cell lung cancer (NSCLC) in murine models, but failed to show clinical efficacy when used in combination with docetaxel in NSCLC patients.	gossypol acetic acid	0-6	B cell leukemia/lymphoma 2	Mus musculus	32-37
26089640-2	2015	Our recent study has demonstrated that AT-101 enhanced the antitumor effect of cisplatin (CDDP) in a murine model of NSCLC via inhibition of the interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway.	gossypol acetic acid	39-45	signal transducer and activator of transcription 3	Mus musculus	145-209
26089640-2	2015	Our recent study has demonstrated that AT-101 enhanced the antitumor effect of cisplatin (CDDP) in a murine model of NSCLC via inhibition of the interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway.	gossypol acetic acid	39-45	signal transducer and activator of transcription 3	Mus musculus	211-216
26089640-6	2015	AT-101 also enhanced the inhibitory effect of CDDP on DNA repair and redox activities of apurinic/apyrimidinic endonuclease 1 (APE1) in A549 cells.	gossypol acetic acid	0-6	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	89-125
25802279-0	2015	Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway.	gossypol acetic acid	0-20	forkhead box O3	Homo sapiens	109-114
25802279-0	2015	Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway.	gossypol acetic acid	0-20	sestrin 2	Homo sapiens	115-123
25802279-3	2015	In this study, we screened U.S. Food and Drug Administration-approved natural compounds and identified gossypol acetic acid (GAA) as a potent inhibitor of oxidative stress-induced RPE cell death.	gossypol acetic acid	103-123	alpha glucosidase	Homo sapiens	125-128
25885284-3	2015	The small-molecule pan-Bcl-2 inhibitor (-)-gossypol (AT-101) is known to induce apoptotic cell death, but can also induce autophagy through release of the pro-autophagic BH3 only protein Beclin-1 from Bcl-2.	gossypol acetic acid	53-59	BCL2 apoptosis regulator	Homo sapiens	23-28
25885284-3	2015	The small-molecule pan-Bcl-2 inhibitor (-)-gossypol (AT-101) is known to induce apoptotic cell death, but can also induce autophagy through release of the pro-autophagic BH3 only protein Beclin-1 from Bcl-2.	gossypol acetic acid	53-59	beclin 1	Homo sapiens	187-195
25885284-3	2015	The small-molecule pan-Bcl-2 inhibitor (-)-gossypol (AT-101) is known to induce apoptotic cell death, but can also induce autophagy through release of the pro-autophagic BH3 only protein Beclin-1 from Bcl-2.	gossypol acetic acid	53-59	BCL2 apoptosis regulator	Homo sapiens	201-206
25530717-0	2014	Induction of H2AX phosphorylation in tumor cells by gossypol acetic acid is mediated by phosphatidylinositol 3-kinase (PI3K) family.	gossypol acetic acid	52-72	H2A.X variant histone	Mus musculus	13-17
25530717-2	2014	Our study shows that gossypol acetic acid (GAA) alone can induce gammaH2AX in Human mucoepidermoid carcinoma cell line (MEC-1) in vitro.	gossypol acetic acid	21-41	alpha glucosidase	Homo sapiens	43-46
25530717-2	2014	Our study shows that gossypol acetic acid (GAA) alone can induce gammaH2AX in Human mucoepidermoid carcinoma cell line (MEC-1) in vitro.	gossypol acetic acid	21-41	H2A.X variant histone	Mus musculus	65-74
25530717-2	2014	Our study shows that gossypol acetic acid (GAA) alone can induce gammaH2AX in Human mucoepidermoid carcinoma cell line (MEC-1) in vitro.	gossypol acetic acid	21-41	ATR serine/threonine kinase	Homo sapiens	120-125
26113054-1	2015	PURPOSE: AT-101 is considered as a putative pan-inhibitor of anti-apoptotic Bcl-2 family protein members acting as a BH3 mimetic.	gossypol acetic acid	9-15	B cell leukemia/lymphoma 2	Mus musculus	76-81
26113054-6	2015	Furthermore, we identified that AT-101 potentially acted on smoothened (Smo) by sharing the same binding site with cyclopamine, a classical Hh signaling pathway inhibitor.	gossypol acetic acid	32-38	smoothened, frizzled class receptor	Mus musculus	60-70
26113054-6	2015	Furthermore, we identified that AT-101 potentially acted on smoothened (Smo) by sharing the same binding site with cyclopamine, a classical Hh signaling pathway inhibitor.	gossypol acetic acid	32-38	smoothened, frizzled class receptor	Mus musculus	72-75
26113054-7	2015	Taking advantage of the patch+/-; p53-/- mouse medulloblastoma model, we observed that AT-101 significantly suppressed the Hh-driven medulloblastoma growth in vitro and in vivo.	gossypol acetic acid	87-93	transformation related protein 53, pseudogene	Mus musculus	34-37
26113054-8	2015	CONCLUSIONS: This study demonstrates that AT-101 significantly and selectively inhibits Hh pathway activity by potentially targeting Smo and consequently suppresses the growth of Hh-driven cancer.	gossypol acetic acid	42-48	smoothened, frizzled class receptor	Mus musculus	133-136
25548514-0	2014	Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.	gossypol acetic acid	26-32	interleukin 6	Homo sapiens	180-184
25548514-0	2014	Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.	gossypol acetic acid	26-32	signal transducer and activator of transcription 3	Homo sapiens	185-190
24434521-0	2014	RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo.	gossypol acetic acid	40-46	ras homolog family member A	Homo sapiens	0-4
24703900-0	2014	Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101.	gossypol acetic acid	145-151	BCL2 apoptosis regulator	Homo sapiens	108-113
24703900-4	2014	METHODS: We exposed GC-resistant MLL-rearranged SEMK2 cells to potent MCL1-inhibiting agents, including gossypol, AT-101, rapamycin, SU9516 and obatoclax (GX15-070) and determined GC sensitisation using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assays.	gossypol acetic acid	114-120	lysine methyltransferase 2A	Homo sapiens	33-36
24703900-6	2014	RESULTS: Only gossypol and its synthetic analogue AT-101 induced GC sensitivity in MLL-rearranged ALL cells.	gossypol acetic acid	50-56	lysine methyltransferase 2A	Homo sapiens	83-86
24703900-8	2014	CONCLUDING REMARKS: In conclusion, gossypol and AT-101 induce GC sensitivity in MLL-rearranged ALL cells, most likely mediated by the activation of BID and BIM without the necessity to down-regulate anti-apoptotic BCL-2 family members like MCL1.	gossypol acetic acid	48-54	lysine methyltransferase 2A	Homo sapiens	80-83
24703900-8	2014	CONCLUDING REMARKS: In conclusion, gossypol and AT-101 induce GC sensitivity in MLL-rearranged ALL cells, most likely mediated by the activation of BID and BIM without the necessity to down-regulate anti-apoptotic BCL-2 family members like MCL1.	gossypol acetic acid	48-54	BCL2 apoptosis regulator	Homo sapiens	214-219
24703900-8	2014	CONCLUDING REMARKS: In conclusion, gossypol and AT-101 induce GC sensitivity in MLL-rearranged ALL cells, most likely mediated by the activation of BID and BIM without the necessity to down-regulate anti-apoptotic BCL-2 family members like MCL1.	gossypol acetic acid	48-54	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	240-244
24703900-9	2014	Hence, co-administration of either gossypol or AT-101 during GC treatment of GC-resistant MLL-rearranged ALL patients may overcome GC resistance and improve prognosis in this high-risk childhood leukaemia.	gossypol acetic acid	47-53	lysine methyltransferase 2A	Homo sapiens	90-93
24236538-4	2014	Thus, we investigated the anti-tumour effects of a pan-BCL2 inhibitor, AT-101, which has high binding specificity for BCL2 and MCL1 in preclinical models of plasma cell cancers (Multiple myeloma and Waldenstrom macroglobulinaemia).	gossypol acetic acid	71-77	BCL2 apoptosis regulator	Homo sapiens	55-59
24236538-4	2014	Thus, we investigated the anti-tumour effects of a pan-BCL2 inhibitor, AT-101, which has high binding specificity for BCL2 and MCL1 in preclinical models of plasma cell cancers (Multiple myeloma and Waldenstrom macroglobulinaemia).	gossypol acetic acid	71-77	BCL2 apoptosis regulator	Homo sapiens	118-122
24236538-4	2014	Thus, we investigated the anti-tumour effects of a pan-BCL2 inhibitor, AT-101, which has high binding specificity for BCL2 and MCL1 in preclinical models of plasma cell cancers (Multiple myeloma and Waldenstrom macroglobulinaemia).	gossypol acetic acid	71-77	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	127-131
24236538-7	2014	This cytotoxic effect and BCL2 downregulation were further potentiated when AT-101 was combined with lenalidomide/dexamethasone (LDA).	gossypol acetic acid	76-82	BCL2 apoptosis regulator	Homo sapiens	26-30
24665650-1	2014	OBJECTIVE: This paper aims to study the effects of gossypol acetic acid (GAA) on proliferation and methylation level of human MutL homologue 1 (hMLH1) gene in human tongue cancer cell line Tca8113.	gossypol acetic acid	51-71	alpha glucosidase	Homo sapiens	73-76
24665650-1	2014	OBJECTIVE: This paper aims to study the effects of gossypol acetic acid (GAA) on proliferation and methylation level of human MutL homologue 1 (hMLH1) gene in human tongue cancer cell line Tca8113.	gossypol acetic acid	51-71	mutL homolog 1	Homo sapiens	144-149
24434521-0	2014	RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo.	gossypol acetic acid	40-46	phosphatase and tensin homolog	Homo sapiens	10-14
24434521-9	2014	Constitutively active Akt prevented the AT-101-induced Mcl-1 downregulation, Bad dephosphorylation, and apoptosis.	gossypol acetic acid	40-46	AKT serine/threonine kinase 1	Homo sapiens	22-25
24434521-9	2014	Constitutively active Akt prevented the AT-101-induced Mcl-1 downregulation, Bad dephosphorylation, and apoptosis.	gossypol acetic acid	40-46	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	55-60
24434521-11	2014	In vivo, the tumor growth inhibition caused by AT-101 was also associated with RhoA/ROCK1/PTEN activation and Akt inactivation in a mouse leukemia xenograft model.	gossypol acetic acid	47-53	ras homolog family member A	Mus musculus	79-83
24434521-11	2014	In vivo, the tumor growth inhibition caused by AT-101 was also associated with RhoA/ROCK1/PTEN activation and Akt inactivation in a mouse leukemia xenograft model.	gossypol acetic acid	47-53	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	84-89
24434521-11	2014	In vivo, the tumor growth inhibition caused by AT-101 was also associated with RhoA/ROCK1/PTEN activation and Akt inactivation in a mouse leukemia xenograft model.	gossypol acetic acid	47-53	phosphatase and tensin homolog	Mus musculus	90-94
24434521-11	2014	In vivo, the tumor growth inhibition caused by AT-101 was also associated with RhoA/ROCK1/PTEN activation and Akt inactivation in a mouse leukemia xenograft model.	gossypol acetic acid	47-53	thymoma viral proto-oncogene 1	Mus musculus	110-113
23708869-0	2013	Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo.	gossypol acetic acid	96-112	BCL2 apoptosis regulator	Homo sapiens	78-83
23685020-3	2014	PATIENTS AND METHODS: A retrospective analysis was conducted on 221 patients with mCRPC treated with docetaxel plus prednisone combined with AT-101 (bcl-2 antagonist) or placebo on a prospective randomized phase II trial.	gossypol acetic acid	141-147	BCL2 apoptosis regulator	Homo sapiens	149-154
24299314-0	2014	Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer.	gossypol acetic acid	50-56	BCL2 apoptosis regulator	Homo sapiens	34-39
23708869-0	2013	Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo.	gossypol acetic acid	96-112	BCL2 like 1	Homo sapiens	88-94
23410041-5	2013	The method was implemented with anticancer activity of Gossypol acetic acid against BCL2 target for colorectal cancer.	gossypol acetic acid	55-75	BCL2 apoptosis regulator	Homo sapiens	84-88
23410041-9	2013	The suggested compounds were further validated by docking study with Gossypol acetic acid and "Tetrahydroisoquinoline amide substituted phenyl pyrazole" cocrystallized with chimeric BCL2-XL (PDBID: 2W3L) protein.	gossypol acetic acid	69-89	BCL2 apoptosis regulator	Homo sapiens	182-186
23708869-7	2013	Bcl-2 and Bcl-xl expression was decreased by 86.5+-1.2% and 35.9+-3.6%, respectively, after treatment with gossypol acetate at 25 micromol/l for 24 h. Preliminary studies in vivo showed that a growth inhibition (T/C) of 30.9% (gossypol acetate 40 mg/kg) was obtained in Balb/C mice bearing Wus1 cells.	gossypol acetic acid	107-123	BCL2 apoptosis regulator	Homo sapiens	0-5
23708869-7	2013	Bcl-2 and Bcl-xl expression was decreased by 86.5+-1.2% and 35.9+-3.6%, respectively, after treatment with gossypol acetate at 25 micromol/l for 24 h. Preliminary studies in vivo showed that a growth inhibition (T/C) of 30.9% (gossypol acetate 40 mg/kg) was obtained in Balb/C mice bearing Wus1 cells.	gossypol acetic acid	107-123	BCL2 like 1	Homo sapiens	10-16
23708869-7	2013	Bcl-2 and Bcl-xl expression was decreased by 86.5+-1.2% and 35.9+-3.6%, respectively, after treatment with gossypol acetate at 25 micromol/l for 24 h. Preliminary studies in vivo showed that a growth inhibition (T/C) of 30.9% (gossypol acetate 40 mg/kg) was obtained in Balb/C mice bearing Wus1 cells.	gossypol acetic acid	227-243	BCL2 apoptosis regulator	Homo sapiens	0-5
23708869-7	2013	Bcl-2 and Bcl-xl expression was decreased by 86.5+-1.2% and 35.9+-3.6%, respectively, after treatment with gossypol acetate at 25 micromol/l for 24 h. Preliminary studies in vivo showed that a growth inhibition (T/C) of 30.9% (gossypol acetate 40 mg/kg) was obtained in Balb/C mice bearing Wus1 cells.	gossypol acetic acid	227-243	BCL2 like 1	Homo sapiens	10-16
23708869-9	2013	Our results demonstrated that the potent inhibitor of Bcl-2 and Bcl-xl gossypol acetate had significant antiproliferative and antiapoptotic effects on multiple myeloma cells in vitro and in vivo.	gossypol acetic acid	71-87	BCL2 like 1	Homo sapiens	64-70
23708869-10	2013	Gossypol acetate may represent a promising new anticancer agent with a novel molecular mechanism and warrants further investigation as a single agent, or in combination with other chemotherapeutics, for human multiple myeloma with Bcl-2 overexpression.	gossypol acetic acid	0-16	BCL2 apoptosis regulator	Homo sapiens	231-236
23734725-2	2013	Small molecule inhibitors such as AT-101 (a BH3-mimetic drug) have been developed to inhibit the antiapoptotic activity of Bcl-2 proteins, which proved effective in restoring radio- and chemo-sensitivity in head and neck cancer cells.	gossypol acetic acid	34-40	BCL2 apoptosis regulator	Homo sapiens	123-128
23734725-3	2013	However, high doses of AT-101 are associated with gastrointestinal, hepatic, and fertility side effects, which prompted the search for other Bcl-2 inhibitors.	gossypol acetic acid	23-29	BCL2 apoptosis regulator	Homo sapiens	141-146
23734725-8	2013	Results also show that combining "smart" anti-Bcl-2 particles with the IC25 of AT-101 (inhibitory concentration responsible for killing 25% of the cells) synergistically inhibits cancer cell proliferation and increases cell apoptosis, which reduce the survival of UM-SCC-17B cancer cells compared to treatment with AT-101 alone.	gossypol acetic acid	79-85	BCL2 apoptosis regulator	Homo sapiens	46-51
23734725-8	2013	Results also show that combining "smart" anti-Bcl-2 particles with the IC25 of AT-101 (inhibitory concentration responsible for killing 25% of the cells) synergistically inhibits cancer cell proliferation and increases cell apoptosis, which reduce the survival of UM-SCC-17B cancer cells compared to treatment with AT-101 alone.	gossypol acetic acid	315-321	BCL2 apoptosis regulator	Homo sapiens	46-51
23269627-1	2013	We investigated the effects of AT-101/cisplatin combination treatment on the expression levels of apoptotic proteins and epigenetic events such as DNA methyltransferase (DNMT) and histone deacetylase (HDAC) enzyme activities in OVCAR-3 and MDAH-2774 ovarian cancer cells.	gossypol acetic acid	31-37	DNA methyltransferase 1	Homo sapiens	147-168
23269627-1	2013	We investigated the effects of AT-101/cisplatin combination treatment on the expression levels of apoptotic proteins and epigenetic events such as DNA methyltransferase (DNMT) and histone deacetylase (HDAC) enzyme activities in OVCAR-3 and MDAH-2774 ovarian cancer cells.	gossypol acetic acid	31-37	DNA methyltransferase 1	Homo sapiens	170-174
23820203-0	2013	Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway.	gossypol acetic acid	0-20	caspase 9	Mus musculus	63-70
23820203-4	2013	Finally, the GA-induced cell apoptosis was evaluated by flow cytometry in the present of caspase inhibitors Z-VAD-FMK and Ac-LEHD-FMK, respectively.	gossypol acetic acid	13-15	caspase 9	Mus musculus	89-96
23820203-7	2013	Notably, GA-induced cell apoptosis was markedly inhibited by caspase inhibitors.	gossypol acetic acid	9-11	caspase 9	Mus musculus	61-68
23820203-8	2013	These results suggest that GA-induced RAW264.7 cell apoptosis may be mediated via a caspase-dependent mitochondrial signaling pathway.	gossypol acetic acid	27-29	caspase 9	Mus musculus	84-91