PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34510656-5	2021	Soil GN increases significantly with soil total N, microbial biomass, and soil pH, but decreases significantly with carbon (C) to N ratio (C: N).	gossypolone	5-7	phenylalanine hydroxylase	Homo sapiens	79-81
11006482-4	2000	The cytotoxicity of gossypol and gossypolone was increased when the tests were performed in the absence of serum and decreased when catalase as well as mannitol were added to the culture medium.	gossypolone	33-44	catalase	Homo sapiens	132-140
33312224-16	2020	The enrichment analysis results showed that the treatment of GN with PS was mainly involved in the TGF-beta1 signaling pathway, MAPK signaling pathway, TNF signaling pathway, NF-kappaB signaling pathway, and PI3K Akt signaling pathway.	gossypolone	61-63	transforming growth factor, beta 1	Rattus norvegicus	99-108
3287100-2	1988	Ninety-two per cent of the GN and 20% of the GP isolates degraded the FN.	gossypolone	27-29	fibronectin 1	Homo sapiens	70-72
4877662-9	1968	Both E M B and SS were more effective when used after GN and Silliker"s than after Selenite.	gossypolone	54-56	embigin	Homo sapiens	5-10
33312224-16	2020	The enrichment analysis results showed that the treatment of GN with PS was mainly involved in the TGF-beta1 signaling pathway, MAPK signaling pathway, TNF signaling pathway, NF-kappaB signaling pathway, and PI3K Akt signaling pathway.	gossypolone	61-63	tumor necrosis factor	Rattus norvegicus	152-155
33312224-16	2020	The enrichment analysis results showed that the treatment of GN with PS was mainly involved in the TGF-beta1 signaling pathway, MAPK signaling pathway, TNF signaling pathway, NF-kappaB signaling pathway, and PI3K Akt signaling pathway.	gossypolone	61-63	AKT serine/threonine kinase 1	Rattus norvegicus	213-216
30097032-6	2018	We validated Gn binding to MSI1 using surface plasmon resonance, nuclear magnetic resonance, and cellular thermal shift assay, and tested the effects of Gn on colon cancer cells and colon cancer DLD-1 xenografts in nude mice.	gossypolone	13-15	musashi RNA-binding protein 1	Mus musculus	27-31
32828311-7	2020	Our results revealed that a Gly-Asn sequence after the initiating Met at the newly generated N-terminus was responsible for delaying corin trafficking in the Golgi.	gossypolone	28-35	corin, serine peptidase	Homo sapiens	133-138
32112355-6	2020	Treatment with AhR agonist benzo(a)pyrene aggravated GN as indicated by a significant increase in serum creatinine, BUN, KIM1, NAGL, CD-86, and urinary albumin/creatinine ratio.	gossypolone	53-55	aryl hydrocarbon receptor	Rattus norvegicus	15-18
32112355-7	2020	On the other hand, treatment with AhR antagonist resveratrol ameliorated GN as manifested by a pronounced decrease in the aforementioned parameters.	gossypolone	73-75	aryl hydrocarbon receptor	Rattus norvegicus	34-37
29916086-6	2018	Our results indicated that the extent of ISD fragmentation could be modulated by CNP and GN concentrations, to obtain MS2 and pseudo-MS3 spectra.	gossypolone	89-91	MS2	Homo sapiens	118-121
29916086-6	2018	Our results indicated that the extent of ISD fragmentation could be modulated by CNP and GN concentrations, to obtain MS2 and pseudo-MS3 spectra.	gossypolone	89-91	MS3	Homo sapiens	133-136
30587978-10	2018	Conclusion: Our findings revealed that DN, GO and GN might interfere with xenobiotic and drug metabolism in the liver by interactions with CYP isoenzymes responsible for the process.	gossypolone	50-52	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	139-142
28117305-5	2017	Noticeable cytotoxicity was observed as the GN dose exceeded this threshold due to upregulated receptor of activator of nuclear factor kB-ligand expression and downregulated osteoprotegerin expression.	gossypolone	44-46	TNF receptor superfamily member 11b	Homo sapiens	174-189
29669828-2	2018	Bovine herpesvirus type 1 (BHV-1) UL49.5 (a gN homolog) contains two predicted cysteine residues, C42 and C78.	gossypolone	44-46	tegument protein VP22	Bovine alphaherpesvirus 1	34-38
28067516-4	2017	It was found that both monomer and dimer forms of HD5 bind to the surface of the GN membrane rather than embedding in the hydrophobic core region of the bilayer.	gossypolone	81-83	defensin alpha 5	Homo sapiens	50-53
12824871-7	2003	Additionally, we also demonstrated coexpression of Gly-Asn-Asn-Lys510-513 (GNNK) + and GNNK - isoforms of the c-kit gene with dominance of the GNNK - transcript in all testicular GCTs.	gossypolone	51-58	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	110-115
20216992-3	2010	Addition of the sugar N -acetyl-D-glucosamine (GN) inhibits responses induced by 0/37 degrees C. Incubation at 0 degrees C shifts GPIbalpha from the membrane skeleton to the cytoskeleton.	gossypolone	47-49	glycoprotein Ib platelet subunit alpha	Homo sapiens	130-139
26835546-3	2016	Due to the strong electrostatic interaction of hBD3 with POPG lipids, which are more prevalent on the GP membrane, its adhesion to the GP membrane is stronger than to the GN membrane and stabilized more rapidly.	gossypolone	171-173	defensin beta 103B	Homo sapiens	47-51
26835546-6	2016	The results of both the GN and the GP membrane simulations show that Arg17, Arg36, and Arg38 form both polar and nonpolar interactions and are potentially the key residues for hBD3 antibacterial activity.	gossypolone	24-26	defensin beta 103B	Homo sapiens	176-180
26835546-7	2016	On the other hand, there was a significant difference in the energy contribution of Arg12 between the GP and GN membrane simulations, suggesting that Arg12 is a key factor in the toxicity of hBD3 to specifically GP bacteria.	gossypolone	109-111	defensin beta 103B	Homo sapiens	191-195
25209806-2	2014	Liquid chromatography-MS/MS analysis showed that the HHV-6 gM/gN complex interacts with the v-SNARE protein, vesicle-associated membrane protein 3 (VAMP3).	gossypolone	62-64	vesicle transport through interaction with t-SNAREs 1B	Homo sapiens	92-99
25209806-2	2014	Liquid chromatography-MS/MS analysis showed that the HHV-6 gM/gN complex interacts with the v-SNARE protein, vesicle-associated membrane protein 3 (VAMP3).	gossypolone	62-64	vesicle associated membrane protein 3	Homo sapiens	148-153
25209806-3	2014	VAMP3 colocalized with the gM/gN complex at the trans-Golgi network and other compartments, possibly the late endosome in HHV-6-infected cells, and its expression gradually increased during the late phase of virus infection.	gossypolone	30-32	vesicle associated membrane protein 3	Homo sapiens	0-5
25209806-4	2014	Finally, VAMP3 was incorporated into mature virions and may be transported with the gM/gN complex.	gossypolone	87-89	vesicle associated membrane protein 3	Homo sapiens	9-14
24646324-3	2014	Here, we show that endogenous PACAP is responsible for the transient arrest phase of GN at the level of the Purkinje cell layer (PCL) but has no effect on B/SC.	gossypolone	85-87	adenylate cyclase activating polypeptide 1	Homo sapiens	30-35
24646324-5	2014	Interestingly, plasminogen activator inhibitor 1 reduces the migration speed of GN in the ML and PCL, and that of B/SC in the ML.	gossypolone	80-82	serpin family E member 1	Homo sapiens	15-48
21990022-3	2011	In this experiment, a novel intravenous (IV) exposure model was used to determine if gestational nicotine (GN) treatment produced alterations in methamphetamine-induced sensitization and the expression of brain-derived neurotrophic factor (BDNF) in the mesocorticolimbic dopamine (DA) system of adolescent offspring.	gossypolone	107-109	brain-derived neurotrophic factor	Rattus norvegicus	205-238
21990022-3	2011	In this experiment, a novel intravenous (IV) exposure model was used to determine if gestational nicotine (GN) treatment produced alterations in methamphetamine-induced sensitization and the expression of brain-derived neurotrophic factor (BDNF) in the mesocorticolimbic dopamine (DA) system of adolescent offspring.	gossypolone	107-109	brain-derived neurotrophic factor	Rattus norvegicus	240-244
21990022-9	2011	Interestingly, GN, but not adolescent methamphetamine treatment, elevated levels of BDNF in the NAcc and Str; however, the GN-induced increase in BDNF in the FC was attenuated by adolescent methamphetamine treatment.	gossypolone	15-17	brain-derived neurotrophic factor	Rattus norvegicus	84-88
21990022-9	2011	Interestingly, GN, but not adolescent methamphetamine treatment, elevated levels of BDNF in the NAcc and Str; however, the GN-induced increase in BDNF in the FC was attenuated by adolescent methamphetamine treatment.	gossypolone	15-17	brain-derived neurotrophic factor	Rattus norvegicus	146-150
21990022-11	2011	These findings indicate that GN exposure will result in increased levels of BDNF protein throughout the mesocorticolimbic DA system during adolescent development and suggests that methamphetamine abuse will modulate the expression of BDNF in motivational circuitries of adolescent offspring exposed to GN.	gossypolone	29-31	brain-derived neurotrophic factor	Rattus norvegicus	76-80
21990022-11	2011	These findings indicate that GN exposure will result in increased levels of BDNF protein throughout the mesocorticolimbic DA system during adolescent development and suggests that methamphetamine abuse will modulate the expression of BDNF in motivational circuitries of adolescent offspring exposed to GN.	gossypolone	29-31	brain-derived neurotrophic factor	Rattus norvegicus	234-238
21990022-11	2011	These findings indicate that GN exposure will result in increased levels of BDNF protein throughout the mesocorticolimbic DA system during adolescent development and suggests that methamphetamine abuse will modulate the expression of BDNF in motivational circuitries of adolescent offspring exposed to GN.	gossypolone	302-304	brain-derived neurotrophic factor	Rattus norvegicus	76-80
21990022-11	2011	These findings indicate that GN exposure will result in increased levels of BDNF protein throughout the mesocorticolimbic DA system during adolescent development and suggests that methamphetamine abuse will modulate the expression of BDNF in motivational circuitries of adolescent offspring exposed to GN.	gossypolone	302-304	brain-derived neurotrophic factor	Rattus norvegicus	234-238
21819714-3	2011	CRP levels were statistically significantly lower on postoperative days 1 and 2 in patients in the DHS versus the GN group; no other differences were observed.	gossypolone	114-116	C-reactive protein	Homo sapiens	0-3