PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12679883-9	2003	In the cells, formycin B, a representative CNT2 ligand, had cis-inhibitory and trans-stimulatory effects on THP uptake.	formycin B	14-24	solute carrier family 28 (sodium-coupled nucleoside transporter), member 2	Mus musculus	43-47
16569664-6	2006	Moreover, inhibition of adenosine transport through the concentrative adenosine plasma membrane transporter CNT2 with formycin B results in the blockade of adenosine-mediated AMPK signaling.	formycin B	118-128	solute carrier family 28 member 2	Rattus norvegicus	108-112
16569664-6	2006	Moreover, inhibition of adenosine transport through the concentrative adenosine plasma membrane transporter CNT2 with formycin B results in the blockade of adenosine-mediated AMPK signaling.	formycin B	118-128	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	175-179
3012799-5	1986	Similar results were obtained with two mutants each of the class B and C type (selected in presence of C-nucleosides formycin A and formycin B), which are also affected in AK but show novel properties.	formycin B	132-142	adenosine kinase	Cricetulus griseus	172-174
1874800-5	1991	A nucleoside transport mutant of S49 cells, AE-1, lacked both the NBTI-sensitive, facilitated and Na(+)-dependent, concentrative formycin B transport activity, but Na(+)-dependent, concentrative transport of alpha-aminoisobutyrate was not affected.	formycin B	129-139	solute carrier family 4 (anion exchanger), member 1	Mus musculus	44-48
3261757-2	1988	In the presence of coformycin, an adenosine deaminase inhibitor, or formycin B, a purine nucleoside phosphorylase inhibitor, DNA cleavage was induced by these nucleosides at concentrations of less than 50 microM.	formycin B	68-78	purine nucleoside phosphorylase	Homo sapiens	82-113
12802208-5	2003	Uptake of [3H]-adenosine via concentrative transporters was studied using the subtype-specific inhibitors thymidine (cit), formycin-B (cif) and tubercidin (cib) and was significantly reduced by thymidine and formycin-B but not by tubercidin.	formycin B	208-218	calcium and integrin binding 1	Rattus norvegicus	156-159
2114620-1	1990	Formycin B [9-deazainosine] was reacted with epoxy-activated Sepharose 6B to form an affinity resin for purine nucleoside phosphorylase (PNPase).	formycin B	0-10	polyribonucleotide nucleotidyltransferase 1	Homo sapiens	137-143
6312294-0	1983	Formycin B-resistant mutants of Chinese hamster ovary cells: novel genetic and biochemical phenotype affecting adenosine kinase.	formycin B	0-10	adenosine kinase	Cricetulus griseus	111-127
2992490-7	1985	These observations strongly indicate that in CHO cells, formycin B is phosphorylated via AK and that like other nucleoside analogs its phosphorylation may be essential for the drugs cellular toxicity.	formycin B	56-66	adenosine kinase	Cricetulus griseus	89-91
2992490-0	1985	Involvement of adenosine kinase in the phosphorylation of formycin B in CHO cells.	formycin B	58-68	adenosine kinase	Cricetulus griseus	15-31
2992490-4	1985	Formycin B-resistant mutants of CHO cells are also affected in AK, as indicated by the absence of AK activity in cell extracts.	formycin B	0-10	adenosine kinase	Cricetulus griseus	63-65
2992490-4	1985	Formycin B-resistant mutants of CHO cells are also affected in AK, as indicated by the absence of AK activity in cell extracts.	formycin B	0-10	adenosine kinase	Cricetulus griseus	98-100
2992490-5	1985	Both types of AK- mutants showed reduced uptake and phosphorylation of [3H]formycin B in comparison to the parental (AK+) cells.	formycin B	75-85	adenosine kinase	Cricetulus griseus	14-16
6771276-1	1980	Purine nucleoside phosphorylase (EC 2.4.2.1) has been purified 715-fold from human granulocytes by formycin B affinity chromatography.	formycin B	99-109	purine nucleoside phosphorylase	Homo sapiens	0-31
6771276-9	1980	Purine nucleoside phosphorylase activity is inhibited by formycin B in a competitive manner and by adenine in a mixed noncompetitive manner.	formycin B	57-67	purine nucleoside phosphorylase	Homo sapiens	0-31
6772548-6	1980	The possibility that formycin B was inhibiting adenosine deaminase, for which it is a product analogue, was studied by the analysis of reaction progress curves using the integrated rate equation.	formycin B	21-31	adenosine deaminase	Homo sapiens	47-66
143819-5	1977	The conformations of formycin and formycin B have strong analogies with those of the 8-bromopurineribosides and differ significantly from those of the 8-azapurineribosides since they adopt preferentially the syn-S-g+ conformation.	formycin B	34-44	synemin	Homo sapiens	208-211
1206009-11	1975	From these results, it was estimated that, under the conditions of replacement culture, formycin B would be converted to formycin in vivo by the action of novel enzyme(s) rather than by the action of enzyme system including adenylosuccinate synthetase and adenylosuccinate lyase.	formycin B	88-98	adenylosuccinate lyase	Homo sapiens	256-278