PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18424135-5	2008	Substitution of the 2-chloro atom with larger and more hydrophobic substituents, such as iodo and alkynyl groups, tended to increase the A(3)AR selectivity (up to 430-fold) in mouse and preserve it in human.	2-chloro	20-28	adenosine A3 receptor	Mus musculus	137-143
21579807-1	2010	In the title compound, C(8)H(5)Br(3)ClNO, the conformation of the N-H bond is syn to the 2-chloro substituent in the benzene ring.	2-chloro	89-97	synemin	Homo sapiens	78-81
21583670-1	2009	The conformation of the N-H bond in the structure of the title compound, C(8)H(7)BrClNO, is syn to the 2-chloro substituent in the aniline ring and anti to both the C=O and C-Br bonds in the side chain, similar to that observed in 2-chloro-N-(2-chloro-phen-yl)acetamide.	2-chloro	103-111	synemin	Homo sapiens	92-95
16840788-9	2006	The 2-chloro pharmacophore, rather than the 2"-deoxyribose was responsible for the reduced 2CdA uptake by hCNT2.	2-chloro	4-12	solute carrier family 28 member 2	Homo sapiens	106-111
21200964-1	2007	The conformation of the N-H bond in the title compound, C(8)H(5)Cl(4)NO, is syn to the 2-chloro substituent and anti to the 5-chloro substituent in the aromatic ring.	2-chloro	87-95	synemin	Homo sapiens	76-79
27863045-3	2016	The fluorescence of the probe was quenched by 2-chloro and 6-phenyl selenium groups; the probe shows high selectivity with NaOCl among other ROS/RNS, and gives a turn-on response.	2-chloro	46-54	FAM20C golgi associated secretory pathway kinase	Homo sapiens	145-148
29753773-4	2018	In particular, compounds having 2-chloro, 3-nitro and 4-methylthio aniline groups at C-4 displayed significant enzymatic inhibitory activity against CDK2 with single digit micromolar IC50 values.	2-chloro	32-40	complement C4A (Rodgers blood group)	Homo sapiens	85-88
29753773-4	2018	In particular, compounds having 2-chloro, 3-nitro and 4-methylthio aniline groups at C-4 displayed significant enzymatic inhibitory activity against CDK2 with single digit micromolar IC50 values.	2-chloro	32-40	cyclin dependent kinase 2	Homo sapiens	149-153
15771421-3	2005	The compounds, mainly 2-chloro-substituted derivatives, were tested in both binding and functional assays at human adenosine receptors (ARs), and many were found to be highly potent and selective A(3)AR agonists.	2-chloro	22-30	adenosine A3 receptor	Homo sapiens	196-202