PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 30107495-9 2018 We used structural models of human Argonaute 2 in complex with guide siRNA featuring 2"-F,4"-Calpha-OMe-U or 2"-F,4"-Cbeta-OMe-U at various sites in the seed region to interpret in vitro activities of siRNAs with the corresponding 2"-/4"-C-modifications. f,4"-calpha-ome 88-103 argonaute RISC catalytic component 2 Homo sapiens 35-46