PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 25636602-4 2015 Therefore the aim of this study was to investigate the effects of chronic 3-bromo 7-nitroindazole (3-Br 7-NI), specific neuronal nitric oxide synthase (nNOS) inhibitor, administration on spatial learning and memory performance in rats using the Morris water maze (MWM) paradigm. 3-bromo-7-nitroindazole 74-97 nitric oxide synthase 1 Rattus norvegicus 152-156 28634231-10 2017 Finally, we show that a recently discovered chemical inhibitor of cry1, 3-bromo-7-nitroindazole, competes for ATP binding and thereby diminishes FADH formation, which demonstrates that both processes are important for cry1 function. 3-bromo-7-nitroindazole 72-95 cryptochrome 1 Arabidopsis thaliana 66-70 28634231-10 2017 Finally, we show that a recently discovered chemical inhibitor of cry1, 3-bromo-7-nitroindazole, competes for ATP binding and thereby diminishes FADH formation, which demonstrates that both processes are important for cry1 function. 3-bromo-7-nitroindazole 72-95 cryptochrome 1 Arabidopsis thaliana 219-223 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 0-23 nitric oxide synthase 1 Rattus norvegicus 60-64 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 0-23 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 201-229 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 0-23 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 231-236 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 0-23 DNA-damage inducible transcript 3 Rattus norvegicus 239-263 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 0-23 DNA-damage inducible transcript 3 Rattus norvegicus 265-269 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 0-23 caspase 12 Rattus norvegicus 283-293 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 0-23 nitric oxide synthase 1 Homo sapiens 350-354 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 25-34 nitric oxide synthase 1 Rattus norvegicus 60-64 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 25-34 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 201-229 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 25-34 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 231-236 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 25-34 DNA-damage inducible transcript 3 Rattus norvegicus 239-263 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 25-34 DNA-damage inducible transcript 3 Rattus norvegicus 265-269 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 25-34 caspase 12 Rattus norvegicus 283-293 28656194-6 2017 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole 25-34 nitric oxide synthase 1 Homo sapiens 350-354 25636602-6 2015 Daily administration of the specific neuronal nitric oxide synthase (nNOS) inhibitor, 3-Br 7-NI impaired the acquisition of the MWM task. 3-bromo-7-nitroindazole 86-95 nitric oxide synthase 1 Rattus norvegicus 69-73 12137973-6 2002 The vasorelaxant effect of PACAP could be significantly reduced by the inhibitor of neuronal N-type calcium channels omega-conotoxin GVIA (omega-CgTx), as well as by 3-bromo-7-nitroindazole (3Br-7-Ni), an inhibitor of the neuronal nitric oxide-synthase (nNOS). 3-bromo-7-nitroindazole 168-189 adenylate cyclase activating polypeptide 1 Rattus norvegicus 27-32 22385503-10 2012 CUMS also significantly decreased BDNF protein levels in the CA1 and CA3 regions of the hippocampus, which was reversed by 3-Br-7-NI and ODQ administration. 3-bromo-7-nitroindazole 123-132 brain-derived neurotrophic factor Rattus norvegicus 34-38 22385503-10 2012 CUMS also significantly decreased BDNF protein levels in the CA1 and CA3 regions of the hippocampus, which was reversed by 3-Br-7-NI and ODQ administration. 3-bromo-7-nitroindazole 123-132 carbonic anhydrase 1 Rattus norvegicus 61-64 22385503-10 2012 CUMS also significantly decreased BDNF protein levels in the CA1 and CA3 regions of the hippocampus, which was reversed by 3-Br-7-NI and ODQ administration. 3-bromo-7-nitroindazole 123-132 carbonic anhydrase 3 Rattus norvegicus 69-72 22075494-0 2012 3-Bromo-7-nitroindazole attenuates brain ischemic injury in diabetic stroke via inhibition of endoplasmic reticulum stress pathway involving CHOP. 3-bromo-7-nitroindazole 0-23 DNA-damage inducible transcript 3 Rattus norvegicus 141-145 22075494-2 2012 The aim of the study was to investigate the neuroprotective potential of 3-bromo-7-nitroindazole (3-BNI), a potent and selective neuronal nitric oxide synthase (nNOS) inhibitor against ER stress and focal cerebral I/R injury associated with comorbid type 2 diabetes in-vivo. 3-bromo-7-nitroindazole 73-96 nitric oxide synthase 1 Rattus norvegicus 129-159 22075494-2 2012 The aim of the study was to investigate the neuroprotective potential of 3-bromo-7-nitroindazole (3-BNI), a potent and selective neuronal nitric oxide synthase (nNOS) inhibitor against ER stress and focal cerebral I/R injury associated with comorbid type 2 diabetes in-vivo. 3-bromo-7-nitroindazole 73-96 nitric oxide synthase 1 Rattus norvegicus 161-165 22075494-2 2012 The aim of the study was to investigate the neuroprotective potential of 3-bromo-7-nitroindazole (3-BNI), a potent and selective neuronal nitric oxide synthase (nNOS) inhibitor against ER stress and focal cerebral I/R injury associated with comorbid type 2 diabetes in-vivo. 3-bromo-7-nitroindazole 98-103 nitric oxide synthase 1 Rattus norvegicus 129-159 22075494-2 2012 The aim of the study was to investigate the neuroprotective potential of 3-bromo-7-nitroindazole (3-BNI), a potent and selective neuronal nitric oxide synthase (nNOS) inhibitor against ER stress and focal cerebral I/R injury associated with comorbid type 2 diabetes in-vivo. 3-bromo-7-nitroindazole 98-103 nitric oxide synthase 1 Rattus norvegicus 161-165 19162139-7 2009 The higher doses of the nNOS inhibitors 1-[2-(trifluoromethyl)phenyl] imidazole (TRIM) and 3-bromo-7-nitroindazole (3Br7NI) inhibited clonic-tonic convulsions induced by a convulsive dose of PTZ (60 mg/kg) in nNOS(+/+) mice. 3-bromo-7-nitroindazole 91-114 nitric oxide synthase 1, neuronal Mus musculus 24-28 19162139-7 2009 The higher doses of the nNOS inhibitors 1-[2-(trifluoromethyl)phenyl] imidazole (TRIM) and 3-bromo-7-nitroindazole (3Br7NI) inhibited clonic-tonic convulsions induced by a convulsive dose of PTZ (60 mg/kg) in nNOS(+/+) mice. 3-bromo-7-nitroindazole 91-114 nitric oxide synthase 1, neuronal Mus musculus 209-213 19162139-7 2009 The higher doses of the nNOS inhibitors 1-[2-(trifluoromethyl)phenyl] imidazole (TRIM) and 3-bromo-7-nitroindazole (3Br7NI) inhibited clonic-tonic convulsions induced by a convulsive dose of PTZ (60 mg/kg) in nNOS(+/+) mice. 3-bromo-7-nitroindazole 116-122 nitric oxide synthase 1, neuronal Mus musculus 209-213 17469926-5 2007 Similar results were observed in mice treated with the selective nNOS inhibitor 3-bromo-7-nitroindazole (3BrN). 3-bromo-7-nitroindazole 80-103 nitric oxide synthase 1, neuronal Mus musculus 65-69 17469926-5 2007 Similar results were observed in mice treated with the selective nNOS inhibitor 3-bromo-7-nitroindazole (3BrN). 3-bromo-7-nitroindazole 105-109 nitric oxide synthase 1, neuronal Mus musculus 65-69 17345819-1 2006 INTRODUCTION: New nitric oxide synthase (NOS) inhibitors: 3-bromo-7-nitroindazole (3-Br-7-NI), 1-(2-trifluoromethylphenyl) imidazole (TRIM), S-methyl-L-thiocitrulline (S-Me-TC) and 7-nitroindazole (7-NI) reduce spontaneous locomotor activity in mice. 3-bromo-7-nitroindazole 58-81 nitric oxide synthase 1, neuronal Mus musculus 18-39 17345819-1 2006 INTRODUCTION: New nitric oxide synthase (NOS) inhibitors: 3-bromo-7-nitroindazole (3-Br-7-NI), 1-(2-trifluoromethylphenyl) imidazole (TRIM), S-methyl-L-thiocitrulline (S-Me-TC) and 7-nitroindazole (7-NI) reduce spontaneous locomotor activity in mice. 3-bromo-7-nitroindazole 83-92 nitric oxide synthase 1, neuronal Mus musculus 18-39 12137973-6 2002 The vasorelaxant effect of PACAP could be significantly reduced by the inhibitor of neuronal N-type calcium channels omega-conotoxin GVIA (omega-CgTx), as well as by 3-bromo-7-nitroindazole (3Br-7-Ni), an inhibitor of the neuronal nitric oxide-synthase (nNOS). 3-bromo-7-nitroindazole 191-199 adenylate cyclase activating polypeptide 1 Rattus norvegicus 27-32 10657997-8 2000 Both DNA damage and cell death in the cerebral cortical neurons were abolished by treatment with 3-bromo-7-nitroindazole (30 mg/kg, intraperitoneal), which specifically inhibited nNOS. 3-bromo-7-nitroindazole 97-120 nitric oxide synthase 1, neuronal Mus musculus 179-183 10195468-2 1999 This study investigated the effects of nitro-L-arginine-methyl ester (L-NAME) and 3-bromo-7-nitroindazole (7-NI) treatment on cNOS catalytic activity and sensorimotor behavioral outcome after TBI. 3-bromo-7-nitroindazole 82-105 nitric oxide synthase 3 Rattus norvegicus 126-130 10195468-2 1999 This study investigated the effects of nitro-L-arginine-methyl ester (L-NAME) and 3-bromo-7-nitroindazole (7-NI) treatment on cNOS catalytic activity and sensorimotor behavioral outcome after TBI. 3-bromo-7-nitroindazole 107-111 nitric oxide synthase 3 Rattus norvegicus 126-130 10195468-5 1999 Pretreatment with L-NAME and 7-NI significantly reduced injury-induced cNOS activation (47.7 +/- 42.6 %, p < 0.05, and 96.16 +/- 12.76, p < 0.05, respectively). 3-bromo-7-nitroindazole 29-33 nitric oxide synthase 3 Rattus norvegicus 71-75 10195468-6 1999 Pretreatment with L-NAME and 7-NI also inhibited cNOS activity within the contralateral noninjured cerebral cortex compared to vehicle-treated rats (L-NAME 43.7 +/- 12.47%, p < 0.05; 7-NI 36.8 +/- 7.47%, p < 0.05). 3-bromo-7-nitroindazole 29-33 nitric oxide synthase 3 Rattus norvegicus 49-53