PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2996557-3	1985	Omeprazole, a substituted benzimidazole, while almost completely abolishing acid production at 10(-4) M, strongly stimulated secretion of preformed and newly synthesized pepsinogen.	benzimidazole	26-39	pepsin II-2/3	Oryctolagus cuniculus	170-180
6326439-1	1984	A number of acyclo nucleosides of benzimidazole derivatives has been synthesized, in which the benzimidazole ring includes substituents at C(5), C(6) and C(2).	benzimidazole	34-47	complement C5	Homo sapiens	139-143
6326439-1	1984	A number of acyclo nucleosides of benzimidazole derivatives has been synthesized, in which the benzimidazole ring includes substituents at C(5), C(6) and C(2).	benzimidazole	34-47	complement C6	Homo sapiens	145-149
6326439-1	1984	A number of acyclo nucleosides of benzimidazole derivatives has been synthesized, in which the benzimidazole ring includes substituents at C(5), C(6) and C(2).	benzimidazole	34-47	complement C2	Homo sapiens	154-158
6326439-1	1984	A number of acyclo nucleosides of benzimidazole derivatives has been synthesized, in which the benzimidazole ring includes substituents at C(5), C(6) and C(2).	benzimidazole	95-108	complement C5	Homo sapiens	139-143
6326439-1	1984	A number of acyclo nucleosides of benzimidazole derivatives has been synthesized, in which the benzimidazole ring includes substituents at C(5), C(6) and C(2).	benzimidazole	95-108	complement C6	Homo sapiens	145-149
6326439-1	1984	A number of acyclo nucleosides of benzimidazole derivatives has been synthesized, in which the benzimidazole ring includes substituents at C(5), C(6) and C(2).	benzimidazole	95-108	complement C2	Homo sapiens	154-158
6419624-0	1983	Effects of KCl and insulin on benzimidazole-inhibited canine gastric secretion.	benzimidazole	30-43	insulin	Canis lupus familiaris	19-26
7097715-2	1982	Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats.	benzimidazole	11-24	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	50-78
6825202-1	1983	A series of benzimidazole derivatives containing additional fused and non-fused aromatic groupings were effective inhibitors of aryl hydrocarbon hydroxylase (PB/AHH) and aminopyrine N-demethylase (ADPM) activities in hepatic microsomes from phenobarbitone(PB)-induced rats.	benzimidazole	12-25	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	128-156
6825202-1	1983	A series of benzimidazole derivatives containing additional fused and non-fused aromatic groupings were effective inhibitors of aryl hydrocarbon hydroxylase (PB/AHH) and aminopyrine N-demethylase (ADPM) activities in hepatic microsomes from phenobarbitone(PB)-induced rats.	benzimidazole	12-25	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	161-164
849331-0	1977	N-Methylation of benzimidazole by catechol-O-methyltransferase.	benzimidazole	17-30	catechol-O-methyltransferase	Homo sapiens	34-62
361093-6	1978	The data presented suggest that several sites of both the tubulin and ligand molecule are involved in the binding of benzimidazole compounds to fungal tubulin.	benzimidazole	117-130	PEX2_027410	Penicillium expansum	58-65
361093-6	1978	The data presented suggest that several sites of both the tubulin and ligand molecule are involved in the binding of benzimidazole compounds to fungal tubulin.	benzimidazole	117-130	PEX2_027410	Penicillium expansum	151-158
284380-2	1979	It is shown that analogs with methyl, amino, or methylamino substituents at position 2 of the benzimidazole ring (position 8 of the purine ring) have predominantly anti conformations, whereas analogs with chloro, aza, methoxy, or methylmercapto substituents have predominantly syn conformations.	benzimidazole	94-107	synemin	Homo sapiens	277-280
33979615-3	2021	Here, we show that PIF proteins control apical hook opening by regulating the expression of Budding Uninhibited by Benzimidazole 3.1 (BUB3.1) and affecting cytokinesis.	benzimidazole	115-128	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	134-140
13653104-0	1959	[Pharmacological study of an antihistaminic from the benzimidazole series: 1-p-chlorobenzyl-2-(1-pyrrolidinylmethyl)-benzimidazole (P-48)].	benzimidazole	53-66	interferon regulatory factor 9	Homo sapiens	132-136
33789191-0	2021	Selective, pH sensitive, "turn on" fluorescence sensing of carbonate ions by a benzimidazole.	benzimidazole	79-92	phenylalanine hydroxylase	Homo sapiens	11-13
33789191-3	2021	A pH-sensitive & selective benzimidazole-based fluorescent sensor has been developed for rapid detection of carbonate ions which can detect carbonate ions in low nanomolar concentrations.	benzimidazole	27-40	phenylalanine hydroxylase	Homo sapiens	2-4
34029540-0	2021	Design, synthesis, and antitumor activity of PLGA nanoparticles incorporating a discovered benzimidazole derivative as EZH2 inhibitor.	benzimidazole	91-104	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	119-123
33348096-2	2021	In this work, a novel quinoline-benzimidazole conjugate containing one carboxylic acid group (QBM) was designed, and the QBM displayed highly selective fluorescence quenching response towards Pd2+ over other metal cations in aqueous solution.	benzimidazole	32-45	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	192-195
33842435-0	2021	New Cationic fac-[Re(CO)3(deeb)B2]+ Complex, Where B2 Is a Benzimidazole Derivative, as a Potential New Luminescent Dye for Proteins Separated by SDS-PAGE.	benzimidazole	59-72	FA complementation group C	Homo sapiens	13-16
31135232-0	2021	Investigation of the toxicological and inhibitory effects of some benzimidazole agents on acetylcholinesterase and butyrylcholinesterase enzymes.	benzimidazole	66-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-110
31135232-0	2021	Investigation of the toxicological and inhibitory effects of some benzimidazole agents on acetylcholinesterase and butyrylcholinesterase enzymes.	benzimidazole	66-79	butyrylcholinesterase	Homo sapiens	115-136
33626870-2	2021	Here, several benzimidazole derivatives have been identified as novel agonists of the melatonin receptors MT1 and MT2.	benzimidazole	14-27	metallothionein 1	Rattus norvegicus	106-109
33663368-0	2022	Synthesis of Some Novel Benzimidazole Derivatives as Anticancer Agent, and Evaluation for CDK2 Inhibition Activity.	benzimidazole	24-37	cyclin dependent kinase 2	Homo sapiens	90-94
33626870-2	2021	Here, several benzimidazole derivatives have been identified as novel agonists of the melatonin receptors MT1 and MT2.	benzimidazole	14-27	metallothionein 2A	Rattus norvegicus	114-117
32955008-0	2021	Repurposing of Benzimidazole Scaffolds for HER-2 Positive Breast Cancer Therapy: An In-Silico Approach.	benzimidazole	15-28	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-48
33738049-0	2021	Novel Benzimidazole Derivatives as Transient Receptor Potential Channel 6 (TRPC6) Inhibitors.	benzimidazole	6-19	transient receptor potential cation channel subfamily C member 6	Homo sapiens	35-73
33738049-0	2021	Novel Benzimidazole Derivatives as Transient Receptor Potential Channel 6 (TRPC6) Inhibitors.	benzimidazole	6-19	transient receptor potential cation channel subfamily C member 6	Homo sapiens	75-80
33535550-0	2021	Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein.	benzimidazole	96-109	BCL2 apoptosis regulator	Homo sapiens	160-165
33535550-3	2021	Within the current work, we aimed to design and synthesize a new series of benzimidazole- and indole-based derivatives as inhibitors of Bcl-2 protein.	benzimidazole	75-88	BCL2 apoptosis regulator	Homo sapiens	136-141
33285268-0	2021	Discovery of a benzimidazole series as the first highly potent and selective ACSL1 inhibitors.	benzimidazole	15-28	acyl-CoA synthetase long-chain family member 1	Mus musculus	77-82
33285268-2	2021	Structure activity relationship studies based on HTS hit compound 1 delivered the benzimidazole series as the first selective and highly potent ACSL1 inhibitors.	benzimidazole	82-95	acyl-CoA synthetase long-chain family member 1	Mus musculus	144-149
33494672-6	2021	Results and Conclusion: It was observed that structures of the GSK-3 inhibitors comprised of benzopyridine, benzthiazole, pyrazole, pyrazine, dioxolo-benzoxazin, oxadiazole, benzimidazole in the skeletal with cyclopropylamide, phenyl carbamothioate, 3-[(propan-2-yl)oxy]propan-1-amine in side chain.	benzimidazole	174-187	glycogen synthase kinase 3 beta	Mus musculus	63-68
33090631-1	2021	Multi ligand self-assembly to attain the AgI-NHC built hexanuclear organometallic cages of composition [Ag6(3a,b)4](PF6)6 from the reaction of benzimidazole derived tris(azolium) salts [H3-3a,b](PF6)3 with Ag2O is presented.	benzimidazole	143-156	H3.3 histone A	Homo sapiens	186-193
33092905-4	2021	Here we utilized the azaindole-based scaffold of FDA-approved BRAF inhibitor vemurafenib 1, which displays off-target activity on MKK4, as a starting point in our fluorescent compound design.	benzimidazole	21-30	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	62-66
33092905-4	2021	Here we utilized the azaindole-based scaffold of FDA-approved BRAF inhibitor vemurafenib 1, which displays off-target activity on MKK4, as a starting point in our fluorescent compound design.	benzimidazole	21-30	mitogen-activated protein kinase kinase 4	Homo sapiens	130-134
32575154-6	2020	Benzimidazole derivative having 4-methoxyphenyl substitution (compound 25) was found to be a selective MAGL inhibitor (IC50 = 9.4 nM), with an IC50 value above 50 microM against FAAH.	benzimidazole	0-13	monoglyceride lipase	Homo sapiens	103-107
33391284-3	2020	Utilizing a recently established TRPC3/6/7 selective, photochromic benzimidazole agonist OptoBI-1, we set out to test this concept for mast cell NFAT signaling.	benzimidazole	67-80	transient receptor potential cation channel, subfamily C, member 3	Rattus norvegicus	33-42
33210922-4	2020	In this work, we present the development of a novel class of azaindole SHP2 inhibitors.	benzimidazole	61-70	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	71-75
33210922-6	2020	The most potent azaindole 45 inhibits SHP2 with an IC50 = 0.031 muM in an enzymatic assay and with an IC50 = 2.6 muM in human pancreas cells (HPAF-II).	benzimidazole	16-25	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	38-42
33174071-2	2021	Results from the in vivo and in vitro tests were compared with benzimidazole (BZ)-resistance-associated beta-tubulin allele frequencies determined using Pyrosequencing .	benzimidazole	63-76	beta-tubulin	Ovis aries	104-116
33174071-2	2021	Results from the in vivo and in vitro tests were compared with benzimidazole (BZ)-resistance-associated beta-tubulin allele frequencies determined using Pyrosequencing .	benzimidazole	78-80	beta-tubulin	Ovis aries	104-116
33174071-6	2021	Genotyping indicated that the susceptible strain had 10% BZ-resistant beta-tubulin codon 200 alleles and the resistant strain had 26% respective resistant alleles.	benzimidazole	57-59	beta-tubulin	Ovis aries	70-82
33391284-6	2020	Expression of any of three benzimidazole-sensitive TRPC isoforms (TRPC3/6/7) reconstituted plasma membrane TRPC conductances in RBL cells, and expression of TRPC6 or TRPC7 enabled light-mediated generation of temporally defined Ca2+ signaling patterns.	benzimidazole	27-40	transient receptor potential cation channel, subfamily C, member 3	Rattus norvegicus	66-75
33391284-6	2020	Expression of any of three benzimidazole-sensitive TRPC isoforms (TRPC3/6/7) reconstituted plasma membrane TRPC conductances in RBL cells, and expression of TRPC6 or TRPC7 enabled light-mediated generation of temporally defined Ca2+ signaling patterns.	benzimidazole	27-40	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	157-162
33391284-6	2020	Expression of any of three benzimidazole-sensitive TRPC isoforms (TRPC3/6/7) reconstituted plasma membrane TRPC conductances in RBL cells, and expression of TRPC6 or TRPC7 enabled light-mediated generation of temporally defined Ca2+ signaling patterns.	benzimidazole	27-40	transient receptor potential cation channel, subfamily C, member 7	Rattus norvegicus	166-171
32575154-6	2020	Benzimidazole derivative having 4-methoxyphenyl substitution (compound 25) was found to be a selective MAGL inhibitor (IC50 = 9.4 nM), with an IC50 value above 50 microM against FAAH.	benzimidazole	0-13	fatty acid amide hydrolase	Homo sapiens	178-182
33207204-2	2020	A major player in determining this balance is the PP2A-B56 phosphatase, which is recruited to the kinase attachment regulatory domain (KARD) of budding uninhibited by benzimidazole 1-related 1 (BUBR1) in a phospho-dependent manner.	benzimidazole	167-180	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	194-199
32738568-0	2020	Novel benzimidazole-triazole hybrids as apoptosis inducing agents in lung cancer: Design, synthesis, 18F-radiolabeling & galectin-1 inhibition studies.	benzimidazole	6-19	galectin 1	Homo sapiens	121-131
32466633-4	2020	MeBib is an HDAC6 inhibitor derived from a benzimidazole scaffold.	benzimidazole	43-56	histone deacetylase 6	Rattus norvegicus	12-17
33247742-8	2020	CONCLUSIONS: The degradation products were identified as benzimidazole (DP1) and amine N-oxide of bilastine (DP2).	benzimidazole	57-70	prostaglandin D2 receptor	Homo sapiens	72-75
32981322-0	2020	Design, Synthesis and Characterization of Benzimidazole Derivatives as PET Imaging Ligands for Metabotropic Glutamate Receptor 2 (mGluR2).	benzimidazole	42-55	glutamate metabotropic receptor 2	Rattus norvegicus	95-128
32981322-0	2020	Design, Synthesis and Characterization of Benzimidazole Derivatives as PET Imaging Ligands for Metabotropic Glutamate Receptor 2 (mGluR2).	benzimidazole	42-55	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	130-136
32981322-1	2020	Three benzimidazole derivatives (13-15) have been synthetized as potential PET imaging ligands for mGluR2 in the brain.	benzimidazole	6-19	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	99-105
32881503-2	2020	The prodrug moiety is attached to a benzimidazole nitrogen via an oxymethyl linkage to allow for rapid and complete release of the drug for absorption following phosphate removal by intestinal alkaline phosphatase.	benzimidazole	36-49	alkaline phosphatase, intestinal	Mus musculus	182-213
32681791-0	2020	Synthesis, investigation of biological effects and in silico studies of new benzimidazole derivatives as aromatase inhibitors.	benzimidazole	76-89	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	105-114
32777641-2	2020	High-throughput virtual screening (HTVS) of a Maybridge small molecule library using the PARP1-benzimidazole-4-carboxamide co-crystal structure and pharmacophore model led to the identification of eleven compounds.	benzimidazole	95-108	poly(ADP-ribose) polymerase 1	Homo sapiens	89-94
32738568-1	2020	In this study, we have synthesized a new series of benzimidazole-triazole hybrids as galectin-1 (gal-1) mediated apoptosis-inducing agents, and evaluated for their potential anticancer activity against a panel of human cancer cell lines viz.	benzimidazole	51-64	galectin 1	Homo sapiens	85-95
32738568-1	2020	In this study, we have synthesized a new series of benzimidazole-triazole hybrids as galectin-1 (gal-1) mediated apoptosis-inducing agents, and evaluated for their potential anticancer activity against a panel of human cancer cell lines viz.	benzimidazole	51-64	galectin 1	Homo sapiens	97-102
32738568-12	2020	Therefore, the novel benzimidazole-triazole hybrids as apoptosis-inducing agents in lung cancer would be potential cytotoxic and PET imaging agents via gal-1.	benzimidazole	21-34	galectin 1	Homo sapiens	152-157
32874920-7	2020	Primary cultured rat and human hepatocytes were considered to be useful for the evaluation of effects of the benzimidazole compounds on their inducibility and inhibitory activities of cytochrome P450 forms.	benzimidazole	109-122	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	184-199
32298535-4	2020	Inspired by the  pharmacodynamics of HYL-6d and the selective PPARgamma ligand VSP-51, the benzimidazole was replaced by a carbazole or an indole core .	benzimidazole	91-104	peroxisome proliferator activated receptor gamma	Homo sapiens	62-71
32713342-0	2021	Design, Synthesis and invitro biological evaluation of Pyridine,thiadazole, Benzimidazole and Acetyl thiophneAnalogues as Anti tubercular Agents Targeting enzyme InhA.	benzimidazole	76-89	inhibin subunit alpha	Homo sapiens	162-166
32713342-4	2021	METHODS: Thus, a series of Pyridine, Thiadiazole, Benzimidazole; and Acetyl thiophene based molecules were designed and docked against crucial mtb enzyme target InhA (Enoyl Acyl Carrier Protein Reductase) Enzyme.	benzimidazole	50-63	inhibin subunit alpha	Homo sapiens	161-165
31382868-4	2020	An interesting benzimidazole fragment was selected from the in silico studies and presented as potential zing binding group for the development of novel HDAC6 selective inhibitors.	benzimidazole	15-28	histone deacetylase 6	Homo sapiens	153-158
32344183-0	2020	Synthesis and anticancer evaluation of novel 1H-benzo[d]imidazole derivatives of dehydroabietic acid as PI3Kalpha inhibitors.	benzimidazole	45-65	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	104-113
32120825-4	2020	Here, we report efficient control of NFAT1 nuclear translocation in human embryonic kidney 293 (HEK293) cells by light, using a new photochromic TRPC benzimidazole activator (OptoBI-1) and a TRPC3 mutant with modified activator sensitivity.	benzimidazole	150-163	nuclear factor of activated T cells 2	Homo sapiens	37-42
32251945-0	2020	Discovery of novel dual PPARalpha/delta agonists based on benzimidazole scaffold for the treatment of non-alcoholic fatty liver disease.	benzimidazole	58-71	peroxisome proliferator activated receptor alpha	Homo sapiens	24-33
32426613-7	2020	Moreover, these devices exhibited lower efficiency roll-off than the CBP-hosted device using the same emitters, which demonstrated the bipolar charge carrier property of carbazole/benzimidazole-based molecules.	benzimidazole	180-193	CREB binding protein	Homo sapiens	69-72
32150677-0	2020	Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity.	benzimidazole	27-40	indoleamine 2,3-dioxygenase 1	Homo sapiens	56-85
32150677-0	2020	Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity.	benzimidazole	27-40	indoleamine 2,3-dioxygenase 1	Homo sapiens	87-91
32150677-1	2020	In this study, a successful medicinal chemistry campaign that exploited virtual, biophysical, and biological investigations led to the identification of a novel class of IDO1 inhibitors based on a benzimidazole substructure.	benzimidazole	197-210	indoleamine 2,3-dioxygenase 1	Homo sapiens	170-174
32307260-0	2020	Synthesis, state-of-the-art NMR-binding and molecular modeling study of new benzimidazole core derivatives as Pin1 inhibitors: Targeting breast cancer.	benzimidazole	76-89	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	110-114
32169404-0	2020	Interruption of Vif/Elongin C interaction: In silico and experimental elucidation of the underlying molecular mechanism of benzimidazole-based APOBEC3G stabilizers.	benzimidazole	123-136	Vif	Human immunodeficiency virus 1	16-19
32169404-0	2020	Interruption of Vif/Elongin C interaction: In silico and experimental elucidation of the underlying molecular mechanism of benzimidazole-based APOBEC3G stabilizers.	benzimidazole	123-136	elongin C	Homo sapiens	20-29
32169404-0	2020	Interruption of Vif/Elongin C interaction: In silico and experimental elucidation of the underlying molecular mechanism of benzimidazole-based APOBEC3G stabilizers.	benzimidazole	123-136	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	143-151
32169404-1	2020	In 2014, two novel and promising benzimidazole-based APOBEC3G stabilizers MM-1 and MM-2 (MMs) were uncovered with an elusive mechanism of action.	benzimidazole	33-46	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	53-61
32169404-1	2020	In 2014, two novel and promising benzimidazole-based APOBEC3G stabilizers MM-1 and MM-2 (MMs) were uncovered with an elusive mechanism of action.	benzimidazole	33-46	plexin B2	Homo sapiens	74-78
32169404-1	2020	In 2014, two novel and promising benzimidazole-based APOBEC3G stabilizers MM-1 and MM-2 (MMs) were uncovered with an elusive mechanism of action.	benzimidazole	33-46	PNMA family member 2	Homo sapiens	83-87
32014680-0	2020	Structural features and functional activities of benzimidazoles as NOD2 antagonists.	benzimidazole	49-63	nucleotide binding oligomerization domain containing 2	Homo sapiens	67-71
31854124-5	2020	To circumvent legislative control measures, SCRA manufacturers have created a wide range of SCRA analogs that contain, more recently, previously unencountered azaindole, gamma-carbolinone, or carbazole heterocyclic scaffolds.	benzimidazole	159-168	anillin, actin binding protein	Homo sapiens	44-48
31854124-5	2020	To circumvent legislative control measures, SCRA manufacturers have created a wide range of SCRA analogs that contain, more recently, previously unencountered azaindole, gamma-carbolinone, or carbazole heterocyclic scaffolds.	benzimidazole	159-168	anillin, actin binding protein	Homo sapiens	92-96
31669219-0	2020	Benzimidazole-based dual dipeptidyl peptidase-4 and xanthine oxidase inhibitors.	benzimidazole	0-13	dipeptidyl peptidase 4	Homo sapiens	25-47
32053964-0	2020	Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles.	benzimidazole	125-157	kinase insert domain receptor	Homo sapiens	35-42
32053964-3	2020	Our second objective was to further optimize the structures of the benzimidazole derivatives through elongation of the side chains at their one-position for the design of more potent type II-like VEGFR-2 inhibitors.	benzimidazole	67-80	kinase insert domain receptor	Homo sapiens	196-203
32053964-4	2020	The designed 1,2-disubstituted benzimidazoles demonstrated potent cytotoxic activity against the HepG2 cell line, reaching IC50 = 1.98 muM in comparison to sorafenib (IC50 = 10.99 muM).	benzimidazole	31-45	latexin	Homo sapiens	135-138
32053964-4	2020	The designed 1,2-disubstituted benzimidazoles demonstrated potent cytotoxic activity against the HepG2 cell line, reaching IC50 = 1.98 muM in comparison to sorafenib (IC50 = 10.99 muM).	benzimidazole	31-45	latexin	Homo sapiens	180-183
32053964-7	2020	Molecular docking studies of the synthesized 1,2-disubstituted benzimidazoles in the VEGFR-2 active site displayed their ability to accomplish the essential hydrogen bonding and hydrophobic interactions for optimum inhibitory activity.	benzimidazole	63-77	kinase insert domain receptor	Homo sapiens	85-92
31922163-1	2020	The mild and efficient palladium-catalyzed ortho C(sp2)-H diversification of (NH)-free 2-substituted benzimidazole, quinazoline, and imidazopyridine is reported using hypervalent iodine as the key reagent.	benzimidazole	101-114	Sp2 transcription factor	Homo sapiens	49-54
31450223-3	2020	Here, we have investigated the mechanism of interaction between AGP and potential Cu/Zn metallo-drugs of benzimidazole derived organic motifs (CuL2 and ZnL2, where L is Schiff base ligand) by applying integrated spectroscopic, biophysical techniques and computational molecular docking analyses.	benzimidazole	105-118	cullin 2	Homo sapiens	143-147
31669219-3	2020	In this study a small series of benzimidazole derivatives (1-9) was evaluated for inhibitory activity against dipeptidyl peptidase-4 (DPP-4) and XO.	benzimidazole	32-45	dipeptidyl peptidase 4	Homo sapiens	110-132
31669219-3	2020	In this study a small series of benzimidazole derivatives (1-9) was evaluated for inhibitory activity against dipeptidyl peptidase-4 (DPP-4) and XO.	benzimidazole	32-45	dipeptidyl peptidase 4	Homo sapiens	134-139
31838286-0	2020	Synthesis and biological evaluation of new benzimidazole-1,2,3-triazole hybrids as potential alpha-glucosidase inhibitors.	benzimidazole	43-71	sucrase-isomaltase	Homo sapiens	93-110
31699396-0	2020	Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study.	benzimidazole	62-75	sucrase-isomaltase	Homo sapiens	20-37
31699396-5	2020	Current study deals with the synthesis and biological screening of benzimidazole bearing bis-Schiff bases (1-19) for their alpha-glucosidase inhibitory activity.	benzimidazole	67-80	sucrase-isomaltase	Homo sapiens	123-140
32357823-0	2020	Synthesis of Some Benzimidazole-derived Molecules and Their Effects on PARP-1 Activity and MDA-MB-231, MDA-MB-436, MDA-MB-468 Breast Cancer Cell Viability.	benzimidazole	18-31	poly(ADP-ribose) polymerase 1	Homo sapiens	71-77
31838286-1	2020	In this study, a series of benzimidazole-1,2,3-triazole hybrids 8a-n as new alpha-glucosidase inhibitors were designed and synthesized.	benzimidazole	27-55	sucrase-isomaltase	Homo sapiens	76-93
31571509-3	2019	Several benzimidazole derivatives 5a-5g and 6a-6c containing various hydrophobic moieties were synthesised, and their inhibitory activity against FLT3 was evaluated.	benzimidazole	8-21	fms related receptor tyrosine kinase 3	Homo sapiens	146-150
31408200-2	2019	Recently, anthelminthic benzimidazoles were shown to promote HIF-1alpha transcription in vitro and were proposed to activate Nurr1 via their benzimidazole group.	benzimidazole	24-37	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	61-71
31408200-2	2019	Recently, anthelminthic benzimidazoles were shown to promote HIF-1alpha transcription in vitro and were proposed to activate Nurr1 via their benzimidazole group.	benzimidazole	24-37	nuclear receptor subfamily 4, group A, member 2	Rattus norvegicus	125-130
31915112-2	2020	The newly synthesized benzimidazole derivatives were evaluated against 4 physiologically relevant CA isoforms (hCA I, II, IX, and XII), and especially the sulfonamide-containing benzimidazoles demonstrated intriguing inhibitory activity against tumor associated CA IX and XII with KI values in the range of 5.2-29.3 nM and 9.9-41.7 nM, respectively.	benzimidazole	22-35	HCA1	Homo sapiens	98-100
31915112-2	2020	The newly synthesized benzimidazole derivatives were evaluated against 4 physiologically relevant CA isoforms (hCA I, II, IX, and XII), and especially the sulfonamide-containing benzimidazoles demonstrated intriguing inhibitory activity against tumor associated CA IX and XII with KI values in the range of 5.2-29.3 nM and 9.9-41.7 nM, respectively.	benzimidazole	22-35	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	111-133
31915112-2	2020	The newly synthesized benzimidazole derivatives were evaluated against 4 physiologically relevant CA isoforms (hCA I, II, IX, and XII), and especially the sulfonamide-containing benzimidazoles demonstrated intriguing inhibitory activity against tumor associated CA IX and XII with KI values in the range of 5.2-29.3 nM and 9.9-41.7 nM, respectively.	benzimidazole	22-35	carbonic anhydrase 9	Homo sapiens	262-267
31915112-2	2020	The newly synthesized benzimidazole derivatives were evaluated against 4 physiologically relevant CA isoforms (hCA I, II, IX, and XII), and especially the sulfonamide-containing benzimidazoles demonstrated intriguing inhibitory activity against tumor associated CA IX and XII with KI values in the range of 5.2-29.3 nM and 9.9-41.7 nM, respectively.	benzimidazole	178-192	HCA1	Homo sapiens	98-100
31915112-2	2020	The newly synthesized benzimidazole derivatives were evaluated against 4 physiologically relevant CA isoforms (hCA I, II, IX, and XII), and especially the sulfonamide-containing benzimidazoles demonstrated intriguing inhibitory activity against tumor associated CA IX and XII with KI values in the range of 5.2-29.3 nM and 9.9-41.7 nM, respectively.	benzimidazole	178-192	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	111-133
31915112-2	2020	The newly synthesized benzimidazole derivatives were evaluated against 4 physiologically relevant CA isoforms (hCA I, II, IX, and XII), and especially the sulfonamide-containing benzimidazoles demonstrated intriguing inhibitory activity against tumor associated CA IX and XII with KI values in the range of 5.2-29.3 nM and 9.9-41.7 nM, respectively.	benzimidazole	178-192	carbonic anhydrase 9	Homo sapiens	262-267
33602088-0	2020	Synthesis, Molecular Docking, and Biological Evaluation of Benzimidazole Derivatives as Selective Butyrylcholinesterase Inhibitors.	benzimidazole	59-72	butyrylcholinesterase	Homo sapiens	98-119
33602088-1	2020	Benzimidazole is an interesting pharmacophore, and its derivatives have been previously shown to possess cholinesterase inhibitory activity.	benzimidazole	0-13	butyrylcholinesterase	Homo sapiens	105-119
33602088-2	2020	In this study, benzimidazole derivatives were synthesized via a 4-step reaction scheme and screened for their acetylcholinesterase and butyrylcholinesterase inhibitory activities.	benzimidazole	15-28	butyrylcholinesterase	Homo sapiens	135-156
31678134-3	2020	Modeling of the interaction of new benzoxazole and benzimidazole derivatives with androgen receptor revealed the destabilization of helix 12, constituting activation function 2 (AF2) site, by mentioned compounds, similar to one induced by known antagonist galeterone.	benzimidazole	51-64	androgen receptor	Homo sapiens	82-99
31787052-2	2019	BubR1 (budding uninhibited by benzimidazole-related 1) is a multifaceted kinase that functions as a mitotic checkpoint.	benzimidazole	30-43	BUB1B, mitotic checkpoint serine/threonine kinase	Mus musculus	0-5
30422010-2	2019	A series of 6,7-dimethoxy-4-anilinoquinolines possessing benzimidazole moiety were synthesised and identified as potent inhibitors of the tyrosine kinase c-Met.	benzimidazole	57-70	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	154-159
31754201-7	2019	We showed that treatment with a benzimidazole derivative bearing a pyrrolidine side chain (compound 9a) inhibited the proliferation of SR cells by blocking the phosphorylation of AKT, p70S6 and the downstream molecule RPS6.	benzimidazole	32-45	ribosomal protein S6	Homo sapiens	218-222
31728454-1	2019	A series of Schiff bases (3.a-f) bearing benzimidazole moiety was successfully synthesized in ethanol by refluxing Oct-2-ynoic acid (1,3-dihydrobenzimidazole-2-ylidene)amide with substituted amines.	benzimidazole	41-54	POU class 2 homeobox 2	Homo sapiens	115-120
31744088-3	2019	In this study, we synthesized novel FXR agonists 1-4 possessing isoxazole and N-substituted benzimidazole moieties, and compared their effects on osteoblast differentiation with the known FXR agonists, chenodeoxycholic acid and a synthetic compound, GW4064.	benzimidazole	92-105	nuclear receptor subfamily 1, group H, member 4	Mus musculus	36-39
31252306-0	2019	Design, synthesis and in vitro evaluation of 6-amide-2-aryl benzoxazole/benzimidazole derivatives against tumor cells by inhibiting VEGFR-2 kinase.	benzimidazole	72-85	kinase insert domain receptor	Homo sapiens	132-139
31671914-0	2019	Antiproliferative Aspect of Benzimidazole Derivatives" Activity and Their Impact on NF-kappaB Expression.	benzimidazole	28-41	nuclear factor kappa B subunit 1	Homo sapiens	84-93
31252306-2	2019	A library of thirty-seven 6-amide-2-aryl benzoxazole/benzimidazole derivatives has been designed and synthesized based on the highly conserved active site of VEGFR-2.	benzimidazole	53-66	kinase insert domain receptor	Homo sapiens	158-165
31384837-3	2019	The selected data set of synthesized benzimidazole compounds was evaluated for its in vitro anticancer activity against cancer cell lines (HCT116 and MCF7) by sulforhodamine B (SRB) assay.	benzimidazole	37-50	chaperonin containing TCP1 subunit 4	Homo sapiens	159-175
31103446-0	2019	Design, synthesis and biological evaluation of benzimidazole derivatives as novel human Pin1 inhibitors.	benzimidazole	47-60	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	88-92
31103446-1	2019	In this work, a series of novel benzimidazole derivatives were designed and synthesized as Pin1 inhibitors.	benzimidazole	32-45	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	91-95
31103446-5	2019	The structure-activity relationships of R1, R2, R3 and linker of the benzimidazole derivatives were analyzed in detail, which would help further exploration of new Pin1 inhibitors.	benzimidazole	69-82	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	164-168
31131561-7	2019	In general, these results indicate that these 6-arylurea-2-arylbenzoxazole/benzimidazole derivatives are promising inhibitors of VEGFR-2 kinase for potential development into anti-angiogenesis drugs.	benzimidazole	75-88	kinase insert domain receptor	Homo sapiens	129-136
31384837-3	2019	The selected data set of synthesized benzimidazole compounds was evaluated for its in vitro anticancer activity against cancer cell lines (HCT116 and MCF7) by sulforhodamine B (SRB) assay.	benzimidazole	37-50	chaperonin containing TCP1 subunit 4	Homo sapiens	177-180
31054862-2	2019	In this study, a benzothiazole- and benzimidazole set of 1-aryl-3-(4-methoxybenzyl)ureas were synthesised as proposed Cys199-targeted covalent inhibitors of GSK-3beta, through the incorporation of an electrophilic warhead onto their ring scaffolds.	benzimidazole	36-49	glycogen synthase kinase 3 alpha	Homo sapiens	157-166
31009910-0	2019	Design, synthesis and docking studies of benzimidazole derivatives as potential EGFR inhibitors.	benzimidazole	41-54	epidermal growth factor receptor	Homo sapiens	80-84
31181622-9	2019	The results indicate the potential for repurposing the benzimidazole anthelmintics for the treatment of cancers overexpressing p53 negative regulators.	benzimidazole	55-68	tumor protein p53	Homo sapiens	127-130
30798155-0	2019	A single point mutation in the TRPC3 lipid-recognition window generates supersensitivity to benzimidazole channel activators.	benzimidazole	92-105	transient receptor potential cation channel subfamily C member 3	Homo sapiens	31-36
30952592-2	2019	Through a highly collaborative and iterative library design, synthesis and testing, a benzimidazole lead was rapidly and systematically advanced to a highly potent, selective and bioavailable DGAT1 inhibitor with the potential for further development.	benzimidazole	86-99	diacylglycerol O-acyltransferase 1	Homo sapiens	192-197
30862488-0	2019	Drug library screen reveals benzimidazole derivatives as selective cytotoxic agents for KRAS-mutant lung cancer.	benzimidazole	28-41	KRAS proto-oncogene, GTPase	Homo sapiens	88-92
30862488-6	2019	The screening identified the cytotoxic effects of benzimidazole derivatives on KRAS-mutant lung cancer cells.	benzimidazole	50-63	KRAS proto-oncogene, GTPase	Homo sapiens	79-83
30862488-7	2019	Treatments with two benzimidazole derivatives, methiazole and fenbendazole-both of which are structurally specific-yielded significant suppression of the RAS-related signaling pathways in KRAS-mutated cells.	benzimidazole	20-33	KRAS proto-oncogene, GTPase	Homo sapiens	188-192
30862488-9	2019	Our study demonstrates that these benzimidazole derivatives play an important role in suppressing KRAS-mutant lung cancer cells, thus offering a novel combinatorial therapeutic approach against such cancer cells.	benzimidazole	34-47	KRAS proto-oncogene, GTPase	Homo sapiens	98-102
30047307-3	2019	Interestingly, the crystal structure of Eg-5 bound to benzimidazole unveils two chemically different allosteric pockets (PDB ID: 3ZCW).	benzimidazole	54-67	kinesin family member 11	Homo sapiens	40-44
30926247-0	2019	Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.	benzimidazole	0-13	diacylglycerol O-acyltransferase 1	Mus musculus	20-25
30926247-1	2019	Previously disclosed benzimidazole-based DGAT1 inhibitors containing a cyclohexane carboxylic acid moiety suffer from isomerization at the alpha position of the carboxylic acid group, generating active metabolites which exhibit DGAT1 inhibition comparable to the corresponding parent compounds.	benzimidazole	21-34	diacylglycerol O-acyltransferase 1	Mus musculus	41-46
30926247-1	2019	Previously disclosed benzimidazole-based DGAT1 inhibitors containing a cyclohexane carboxylic acid moiety suffer from isomerization at the alpha position of the carboxylic acid group, generating active metabolites which exhibit DGAT1 inhibition comparable to the corresponding parent compounds.	benzimidazole	21-34	diacylglycerol O-acyltransferase 1	Mus musculus	228-233
30926247-2	2019	In this report, we describe the design, synthesis and profiling of benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.	benzimidazole	67-80	diacylglycerol O-acyltransferase 1	Mus musculus	87-92
32255081-5	2019	As the plug, the beta-CD ring was initially located at the Bz position.	benzimidazole	59-61	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	17-24
32255081-6	2019	In an acidic tumor microenvironment, the pH sensitive Bz was protonated and the complex formation constant between Bz and beta-CD decreased.	benzimidazole	54-56	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	122-129
32255081-6	2019	In an acidic tumor microenvironment, the pH sensitive Bz was protonated and the complex formation constant between Bz and beta-CD decreased.	benzimidazole	115-117	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	122-129
30940396-1	2019	Indole- and azaindole-based glyoxylyl amide derivatives have been described as HIV-1 attachment inhibitors (AIs) that act by blocking the interaction between the viral gp120 coat protein and the human host cell CD4 receptor.	benzimidazole	12-21	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	168-173
30940396-1	2019	Indole- and azaindole-based glyoxylyl amide derivatives have been described as HIV-1 attachment inhibitors (AIs) that act by blocking the interaction between the viral gp120 coat protein and the human host cell CD4 receptor.	benzimidazole	12-21	CD4 molecule	Homo sapiens	211-223
31103918-11	2019	Molecular docking studies show that the amino acid residues 664-666 in the hinge region of the cytosolic domain of CSF1R to be the preferred region of binding for nitroindole and azaindole derivatives.	benzimidazole	179-188	colony stimulating factor 1 receptor	Homo sapiens	115-120
30714356-1	2019	Using a scaffold-hopping approach, imidazo[1,2-a]pyridine analogues of the ZSTK474 (benzimidazole) class of phosphatidylinositol 3-kinase (PI3K) inhibitors have been synthesized for biological evaluation.	benzimidazole	84-97	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	108-137
30707023-3	2019	High-throughput screening resulted in the identification of benzimidazole derivatives as novel hEP4-R antagonists.	benzimidazole	60-73	prostaglandin E receptor 4	Homo sapiens	95-99
30934730-0	2019	Structure-Based Design of Novel Benzimidazole Derivatives as Pin1 Inhibitors.	benzimidazole	32-45	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	61-65
30934730-3	2019	Aiming to develop potent Pin1 inhibitors, a series of benzimidazole derivatives were designed and synthesized.	benzimidazole	54-67	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	25-29
30934730-6	2019	Taken together, these unique benzimidazole derivatives exhibited great potential to be further explored as potent Pin1 inhibitors with improved potency.	benzimidazole	29-42	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	114-118
29608549-3	2019	Budding uninhibited by benzimidazole-1 (Bub1) plays a role in Akt and JNK signaling, which control TF and TM, respectively.	benzimidazole	23-36	BUB1, mitotic checkpoint serine/threonine kinase	Mus musculus	40-44
30496702-2	2019	In this study, heat shock delayed the onset of anaphase by increasing the number of misoriented cells, accompanied by the kinetochore localization of budding uninhibited by benzimidazole-related (BubR)1 in a monopolar spindle (Mps)1-dependent manner.	benzimidazole	173-186	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	196-202
29608549-3	2019	Budding uninhibited by benzimidazole-1 (Bub1) plays a role in Akt and JNK signaling, which control TF and TM, respectively.	benzimidazole	23-36	thymoma viral proto-oncogene 1	Mus musculus	62-65
29608549-3	2019	Budding uninhibited by benzimidazole-1 (Bub1) plays a role in Akt and JNK signaling, which control TF and TM, respectively.	benzimidazole	23-36	mitogen-activated protein kinase 8	Mus musculus	70-73
29608549-3	2019	Budding uninhibited by benzimidazole-1 (Bub1) plays a role in Akt and JNK signaling, which control TF and TM, respectively.	benzimidazole	23-36	coagulation factor III	Mus musculus	99-101
30809119-5	2019	Benzimidazole derivatives also reduced TNF-alpha expression in mice.	benzimidazole	0-13	tumor necrosis factor	Mus musculus	39-48
30823470-0	2019	Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives.	benzimidazole	46-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-18
30823470-5	2019	Among them, compounds 3d and 3h, which featured 3,4-dihydroxy substitution at the phenyl ring and 5(6)-chloro substitution at the benzimidazole ring were found to be potent inhibitors of AChE.	benzimidazole	130-143	acetylcholinesterase (Cartwright blood group)	Homo sapiens	187-191
30664786-2	2019	In a screen for compounds that restore radiosensitivity in p53 mutant zebrafish while tolerated in non-irradiated wild-type animals, we identified the benzimidazole anthelmintic oxfendazole.	benzimidazole	151-164	tumor protein p53	Danio rerio	59-62
29777201-4	2019	Here, based on published structure and activity of GDC-0449 inhibitor class, we replaced its amide core with benzimidazole which retained bulk of the SMO-targeting activity as measured in our Hh/SMO/Gli1-reporter system.	benzimidazole	109-122	smoothened, frizzled class receptor	Mus musculus	150-153
29777201-4	2019	Here, based on published structure and activity of GDC-0449 inhibitor class, we replaced its amide core with benzimidazole which retained bulk of the SMO-targeting activity as measured in our Hh/SMO/Gli1-reporter system.	benzimidazole	109-122	smoothened, frizzled class receptor	Mus musculus	195-198
29777201-4	2019	Here, based on published structure and activity of GDC-0449 inhibitor class, we replaced its amide core with benzimidazole which retained bulk of the SMO-targeting activity as measured in our Hh/SMO/Gli1-reporter system.	benzimidazole	109-122	GLI-Kruppel family member GLI1	Mus musculus	199-203
30538066-4	2019	Work reported here evaluates the benzimidazole scaffold and substituents resulting in the discovery of AC1903, a TRPC5 inhibitor that is active in multiple animal models of CKD.	benzimidazole	33-46	transient receptor potential cation channel subfamily C member 5	Homo sapiens	113-118
30538065-2	2019	Core hopping from our previously reported phenylimidazole leads has allowed the identification of a novel series of benzimidazole NaV1.8 blockers.	benzimidazole	116-129	sodium voltage-gated channel alpha subunit 10	Homo sapiens	130-136
29992893-2	2019	Bendamustine (Alkylating agent), Nocodazole (Mitotic inhibitor), Veliparib (PARP inhibitor), and Glasdegib (SMO inhibitor) are being clinically used as anticancer therapeutic which bear benzimidazole moiety.	benzimidazole	186-199	poly(ADP-ribose) polymerase 1	Homo sapiens	76-80
30280671-0	2019	3D-QSAR and Molecular Docking Studies on Oxadiazole Substituted Benzimidazole Derivatives: Validation of Experimental Inhibitory Potencies Towards COX-2.	benzimidazole	64-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
30280671-2	2019	Benzimidazole derivatives showed promising anti-inflammatory activity through the inhibition of COX-2 enzyme.	benzimidazole	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
30727904-14	2019	The present series of 1H-benzimidazoles could be considered promising broad-spectrum antimicrobial candidates that deserve in future for preclinical antimicrobial evaluation and development of newer antimicrobial agents targeting microbial DHFR.	benzimidazole	22-39	dihydrofolate reductase	Homo sapiens	240-244
29992893-2	2019	Bendamustine (Alkylating agent), Nocodazole (Mitotic inhibitor), Veliparib (PARP inhibitor), and Glasdegib (SMO inhibitor) are being clinically used as anticancer therapeutic which bear benzimidazole moiety.	benzimidazole	186-199	smoothened, frizzled class receptor	Homo sapiens	108-111
30310908-0	2018	Acylhydrazone functionalized benzimidazole-based metallogel for the efficient detection and separation of Cr3.	benzimidazole	29-42	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	106-109
30264679-3	2019	As in literature, azaindole is a very potent moiety, its derivatives displayed a number of biological activities such as kinase inhibitors, cytotoxic agents, anti-angiogenic activity, CRTh2 receptor antagonists, melanin agonists, nicotine agonists, effectiveness in alzheimer disease, cytokinin analogs, Orai inhibitors in asthma and chemokine receptor- 2 (CCR2) antagonists.	benzimidazole	18-27	prostaglandin D2 receptor 2	Homo sapiens	184-189
30264679-3	2019	As in literature, azaindole is a very potent moiety, its derivatives displayed a number of biological activities such as kinase inhibitors, cytotoxic agents, anti-angiogenic activity, CRTh2 receptor antagonists, melanin agonists, nicotine agonists, effectiveness in alzheimer disease, cytokinin analogs, Orai inhibitors in asthma and chemokine receptor- 2 (CCR2) antagonists.	benzimidazole	18-27	C-C motif chemokine receptor 2	Homo sapiens	334-355
30264679-3	2019	As in literature, azaindole is a very potent moiety, its derivatives displayed a number of biological activities such as kinase inhibitors, cytotoxic agents, anti-angiogenic activity, CRTh2 receptor antagonists, melanin agonists, nicotine agonists, effectiveness in alzheimer disease, cytokinin analogs, Orai inhibitors in asthma and chemokine receptor- 2 (CCR2) antagonists.	benzimidazole	18-27	C-C motif chemokine receptor 2	Homo sapiens	357-361
30547095-4	2018	To extend the SAR investigation of the indole-2-carboxamide class of CB1 allosteric modulators, azaindole (pyrrolopyridine) rings were used to replace the indole ring of Org27569 analogs to explore the potential of azaindole-2-carboxamides as CB1 allosteric modulators.	benzimidazole	96-105	cannabinoid receptor 1	Homo sapiens	243-246
30371063-7	2018	Furthermore, several representative privileged substructures that are essential for FXR binders, such as benzimidazole, indole, and stilbene moiety, were detected using information gain and substructure frequency analysis.	benzimidazole	105-118	nuclear receptor subfamily 1 group H member 4	Homo sapiens	84-87
30500781-5	2018	The anticancer potential of the selected benzimidazole derivatives was evaluated against two selected cell lines (human colorectal cancer, HCT-116 and breast adenocarcinoma, MCF-7) using sulforhodamine B (SRB) assay.	benzimidazole	41-54	chaperonin containing TCP1 subunit 4	Homo sapiens	187-203
30500781-5	2018	The anticancer potential of the selected benzimidazole derivatives was evaluated against two selected cell lines (human colorectal cancer, HCT-116 and breast adenocarcinoma, MCF-7) using sulforhodamine B (SRB) assay.	benzimidazole	41-54	chaperonin containing TCP1 subunit 4	Homo sapiens	205-208
30075436-0	2018	A new multifunctional benzimidazole tagged coumarin as ratiometric fluorophore for the detection of Cd2+/F- ions and imaging in live cells.	benzimidazole	22-35	CD2 molecule	Homo sapiens	100-103
30310908-3	2018	A novel metallogel chemosensor (BMG-Fe) based on functionalized benzimidazole (BM) and Fe3+ was constructed, which could fluorescently detect and separate Cr3+.	benzimidazole	64-77	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	155-158
30310908-3	2018	A novel metallogel chemosensor (BMG-Fe) based on functionalized benzimidazole (BM) and Fe3+ was constructed, which could fluorescently detect and separate Cr3+.	benzimidazole	32-34	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	155-158
30170943-1	2018	Utilizing the already described 3,4-bi-aryl pyridine series as a starting point, incorporation of a second ring system with a hydrogen bond donor and additional hydrophobic contacts yielded the azaindole series which exhibited potent, picomolar RSK2 inhibition and the most potent in vitro target modulation seen thus far for a RSK inhibitor.	benzimidazole	194-203	ribosomal protein S6 kinase A3	Homo sapiens	245-249
30270370-2	2018	Herein, we report the exploration of benzimidazole-containing aramid fibers (B-ANF) for the naked-eye detection of heavy metal ions in aqueous solution.	benzimidazole	37-50	HESX homeobox 1	Homo sapiens	79-82
30270370-3	2018	Firstly, B-ANF was prepared by hydroxylation from benzimidazole-containing aramid fiber.	benzimidazole	50-63	HESX homeobox 1	Homo sapiens	11-14
30411010-0	2018	Efficient Synthesis and in Silico Studies of the Benzimidazole Hybrid Scaffold with the Quinolinyloxadiazole Skeleton with Potential alpha-Glucosidase Inhibitory, Anticoagulant, and Antiplatelet Activities for Type-II Diabetes Mellitus Management and Treating Thrombotic Disorders.	benzimidazole	49-62	sucrase-isomaltase	Homo sapiens	133-150
30411010-4	2018	In addition, molecular docking studies revealed that benzimidazole-containing quinolinyl oxadiazoles can correctly dock into the target receptor protein of the human intestinal alpha-glucosidase, while their bioavailability/drug-likeness was predicted to be acceptable but requires further optimization.	benzimidazole	53-66	sucrase-isomaltase	Homo sapiens	177-194
30411010-9	2018	These findings reveal that benzimidazole-containing quinolinyl oxadiazoles act as alpha-glucosidase inhibitors to develop novel therapeutics for treating type-II diabetes mellitus and can act as lead molecules in drug discovery as potential antidiabetic and antithrombotic agents.	benzimidazole	27-40	sucrase-isomaltase	Homo sapiens	82-99
30277375-4	2018	The oligoethylenimine-conjugated beta-cyclodextrin (beta-CD-PEI600) and benzimidazole-modified four-arm-polycaprolactone-initiated hyperbranched polyglycerol (PCL-HPG-BM) were synthesized as the host and guest molecules, respectively, and then the co-delivery carrier of PCL-HPG-PEI600 was formed from the pH-mediated inclusion interaction between beta-CD and BM.	benzimidazole	72-85	PHD finger protein 1	Homo sapiens	159-162
30277375-4	2018	The oligoethylenimine-conjugated beta-cyclodextrin (beta-CD-PEI600) and benzimidazole-modified four-arm-polycaprolactone-initiated hyperbranched polyglycerol (PCL-HPG-BM) were synthesized as the host and guest molecules, respectively, and then the co-delivery carrier of PCL-HPG-PEI600 was formed from the pH-mediated inclusion interaction between beta-CD and BM.	benzimidazole	72-85	PHD finger protein 1	Homo sapiens	271-274
30170943-1	2018	Utilizing the already described 3,4-bi-aryl pyridine series as a starting point, incorporation of a second ring system with a hydrogen bond donor and additional hydrophobic contacts yielded the azaindole series which exhibited potent, picomolar RSK2 inhibition and the most potent in vitro target modulation seen thus far for a RSK inhibitor.	benzimidazole	194-203	ribosomal protein S6 kinase A3	Homo sapiens	245-248
30157472-3	2018	Among the intracellular factors, age-dependent decrease of BubR1 (budding uninhibited by benzimidazole-related 1), YAP (Yes-associated protein) and SIRT1 (Sirtuin-1) have been associated to dampening of tissue reconstitution and inhibition of cell cycle genes following partial hepatectomy.	benzimidazole	89-102	BUB1B, mitotic checkpoint serine/threonine kinase	Mus musculus	59-64
30205005-0	2018	Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.	benzimidazole	46-59	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	82-86
30205005-4	2018	Here, we describe a new series of benzimidazole-derived SOS1 agonists.	benzimidazole	34-47	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	56-60
30647880-1	2018	Herein we continued our previous work on the development of CB2 ligands, reporting the design and synthesis of a series of benzimidazole-containing derivatives that were explored as selective CB2 ligands with binding affinity towards both CB1 and CB2 receptors.	benzimidazole	123-136	cannabinoid receptor 2	Homo sapiens	60-63
30647880-1	2018	Herein we continued our previous work on the development of CB2 ligands, reporting the design and synthesis of a series of benzimidazole-containing derivatives that were explored as selective CB2 ligands with binding affinity towards both CB1 and CB2 receptors.	benzimidazole	123-136	cannabinoid receptor 2	Homo sapiens	192-195
30647880-1	2018	Herein we continued our previous work on the development of CB2 ligands, reporting the design and synthesis of a series of benzimidazole-containing derivatives that were explored as selective CB2 ligands with binding affinity towards both CB1 and CB2 receptors.	benzimidazole	123-136	cannabinoid receptor 1	Homo sapiens	239-242
30647880-1	2018	Herein we continued our previous work on the development of CB2 ligands, reporting the design and synthesis of a series of benzimidazole-containing derivatives that were explored as selective CB2 ligands with binding affinity towards both CB1 and CB2 receptors.	benzimidazole	123-136	cannabinoid receptor 2	Homo sapiens	192-195
29966873-0	2018	Biological properties and structural study of new aminoalkyl derivatives of benzimidazole and benzotriazole, dual inhibitors of CK2 and PIM1 kinases.	benzimidazole	76-89	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	136-140
29864685-2	2018	In light of this, a series of benzimidazole scaffold based hybrid molecules were designed by integrating benzimidazoles (containing pharmacophoric elements for COXs and LOXs inhibitors) with phthalimide subunit of thalidomide (pharmacophore element for TNF-alpha inhibitor) under one construct via molecular hybridization strategy.	benzimidazole	30-43	tumor necrosis factor	Mus musculus	253-262
30396261-2	2018	Recently, the spindle checkpoint kinase budding uninhibited by benzimidazole-related 1 (BubR1) has emerged as a key determinant for age-related pathology in various tissues including brain.	benzimidazole	63-76	BUB1B, mitotic checkpoint serine/threonine kinase	Mus musculus	88-93
29775710-2	2018	Dual pH-sensitive supramolecular micelles were formed from beta-CD-(PDMAEMA)7 and benzimidazole modified poly(epsilon-caprolactone) (BM-PCL) through the host-guest interactions between beta-CD and benzimidazole.	benzimidazole	82-95	PHD finger protein 1	Homo sapiens	136-139
29571113-0	2018	Synthesis of stable benzimidazole derivatives bearing pyrazole as anticancer and EGFR receptor inhibitors.	benzimidazole	20-33	epidermal growth factor receptor	Homo sapiens	81-85
29989628-2	2018	The 1H NMR and crystal structure measurements indicate that both 1 PF6 and 2 PF6 contain intramolecular pipi stacking interactions between the non-coordinated N-methylbenzoimidazole/benzimidazole unit and the tpy ligand, but there are no such pipi interactions in 3 PF6.	benzimidazole	182-195	sperm associated antigen 17	Homo sapiens	67-70
28974341-1	2018	OBJECTIVES: Budding uninhibited by benzimidazole-related 1 (BubR1), a cell cycle-related protein, is an essential component of the spindle checkpoint that regulates cell division.	benzimidazole	35-48	BUB1B, mitotic checkpoint serine/threonine kinase	Mus musculus	60-65
29989628-2	2018	The 1H NMR and crystal structure measurements indicate that both 1 PF6 and 2 PF6 contain intramolecular pipi stacking interactions between the non-coordinated N-methylbenzoimidazole/benzimidazole unit and the tpy ligand, but there are no such pipi interactions in 3 PF6.	benzimidazole	182-195	sperm associated antigen 17	Homo sapiens	77-80
29989628-2	2018	The 1H NMR and crystal structure measurements indicate that both 1 PF6 and 2 PF6 contain intramolecular pipi stacking interactions between the non-coordinated N-methylbenzoimidazole/benzimidazole unit and the tpy ligand, but there are no such pipi interactions in 3 PF6.	benzimidazole	182-195	sperm associated antigen 17	Homo sapiens	77-80
28784429-8	2018	FLAP inhibitors reviewed herein are classified into four sub-classes as the first-generation FLAP inhibitors (indole and quinoline derivatives), the second-generation FLAP inhibitors (diaryl-alkanes and biaryl amino-heteroarenes), the benzimidazole-containing FLAP inhibitors and other FLAP inhibitors with polypharmacology for easiness of the reader.	benzimidazole	235-248	arachidonate 5-lipoxygenase activating protein	Homo sapiens	0-4
29991770-0	2018	Radiobrominated benzimidazole-quinoline derivatives as Platelet-derived growth factor receptor beta (PDGFRbeta) imaging probes.	benzimidazole	16-29	platelet derived growth factor receptor beta	Homo sapiens	55-99
29991770-0	2018	Radiobrominated benzimidazole-quinoline derivatives as Platelet-derived growth factor receptor beta (PDGFRbeta) imaging probes.	benzimidazole	16-29	platelet derived growth factor receptor beta	Homo sapiens	101-110
29748388-6	2018	We identified specific interactions of CENP-F and CENP-E with budding uninhibited by benzimidazole 1 (BUB1) and BUB1-related (BUBR1) mitotic checkpoint Ser/Thr kinases, respectively, paralogous proteins involved in mitotic checkpoint control and chromosome alignment.	benzimidazole	85-98	centromere protein F	Homo sapiens	39-45
29748388-6	2018	We identified specific interactions of CENP-F and CENP-E with budding uninhibited by benzimidazole 1 (BUB1) and BUB1-related (BUBR1) mitotic checkpoint Ser/Thr kinases, respectively, paralogous proteins involved in mitotic checkpoint control and chromosome alignment.	benzimidazole	85-98	centromere protein E	Homo sapiens	50-56
29754833-0	2018	Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.	benzimidazole	13-26	renin	Rattus norvegicus	56-61
29754833-7	2018	Consequently, a series of novel benzimidazole derivatives were discovered as potent and orally bioavailable renin inhibitors.	benzimidazole	32-45	renin	Rattus norvegicus	108-113
29748388-6	2018	We identified specific interactions of CENP-F and CENP-E with budding uninhibited by benzimidazole 1 (BUB1) and BUB1-related (BUBR1) mitotic checkpoint Ser/Thr kinases, respectively, paralogous proteins involved in mitotic checkpoint control and chromosome alignment.	benzimidazole	85-98	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	102-106
29669921-3	2018	Herein, we describe the design, synthesis, and evaluation of a collection of N-arylated benzimidazole derivatives (BIMs), one of which (BIM1) shows unparalleled (>20-fold) selectivity for CLC-Ka over CLC-Kb, the two most closely related human CLC homologs.	benzimidazole	88-101	Charcot-Leyden crystal galectin	Homo sapiens	191-194
29669921-3	2018	Herein, we describe the design, synthesis, and evaluation of a collection of N-arylated benzimidazole derivatives (BIMs), one of which (BIM1) shows unparalleled (>20-fold) selectivity for CLC-Ka over CLC-Kb, the two most closely related human CLC homologs.	benzimidazole	88-101	chloride voltage-gated channel Kb	Homo sapiens	203-209
29669921-3	2018	Herein, we describe the design, synthesis, and evaluation of a collection of N-arylated benzimidazole derivatives (BIMs), one of which (BIM1) shows unparalleled (>20-fold) selectivity for CLC-Ka over CLC-Kb, the two most closely related human CLC homologs.	benzimidazole	88-101	Charcot-Leyden crystal galectin	Homo sapiens	203-206
29783777-0	2018	Preferential Inhibition of Wnt/beta-Catenin Signaling by Novel Benzimidazole Compounds in Triple-Negative Breast Cancer.	benzimidazole	63-76	catenin beta 1	Homo sapiens	31-43
28585189-2	2018	The new anticoagulant dabigatran etexilate (DE) is a direct thrombin inhibitor that owns benzimidazole group, which has been proposed to activate Nurr1.	benzimidazole	89-102	coagulation factor II	Rattus norvegicus	60-68
28585189-2	2018	The new anticoagulant dabigatran etexilate (DE) is a direct thrombin inhibitor that owns benzimidazole group, which has been proposed to activate Nurr1.	benzimidazole	89-102	nuclear receptor subfamily 4, group A, member 2	Rattus norvegicus	146-151
29731445-7	2018	Among all Angiotensin II Receptor Antagonists/Blockers (ARBs), Telmisartan, Milfasartan and many others have benzimidazole ring in their structure.	benzimidazole	109-122	angiotensinogen	Homo sapiens	10-24
29597170-3	2018	C (5)-substitution of the benzimidazole ring of BRP-7 by carboxylic acid and its bioisosteres provided compounds, exemplified by 57 that potently suppress LT formation (IC50 = 0.05 muM) by targeting FLAP along with inhibition of mPGES-1 (IC50 = 0.42 muM).	benzimidazole	26-39	arachidonate 5-lipoxygenase activating protein	Homo sapiens	199-203
29597170-3	2018	C (5)-substitution of the benzimidazole ring of BRP-7 by carboxylic acid and its bioisosteres provided compounds, exemplified by 57 that potently suppress LT formation (IC50 = 0.05 muM) by targeting FLAP along with inhibition of mPGES-1 (IC50 = 0.42 muM).	benzimidazole	26-39	prostaglandin E synthase	Mus musculus	229-236
29407951-0	2018	Design, synthesis and biological evaluation of novel indole-benzimidazole hybrids targeting estrogen receptor alpha (ER-alpha).	benzimidazole	60-73	estrogen receptor 1	Homo sapiens	92-115
29382705-3	2018	Here, we report the discovery of the azaindole compounds BDP8900 and BDP9066 as potent and selective MRCK inhibitors that reduce substrate phosphorylation, leading to morphologic changes in cancer cells along with inhibition of their motility and invasive character.	benzimidazole	37-46	CDC42 binding protein kinase alpha	Homo sapiens	101-105
29174667-2	2018	The dye-labeled probe aptamer (PA) product was adsorbed onto the benzimidazole derivative-containing Cu-MOG via electrostatic incorporation and strong pi-pi stacking interactions, which significantly increased the FA value due to the enlargement of the molecular volume of the PA/Cu-MOG complex.	benzimidazole	65-78	myelin oligodendrocyte glycoprotein	Homo sapiens	104-107
29174667-2	2018	The dye-labeled probe aptamer (PA) product was adsorbed onto the benzimidazole derivative-containing Cu-MOG via electrostatic incorporation and strong pi-pi stacking interactions, which significantly increased the FA value due to the enlargement of the molecular volume of the PA/Cu-MOG complex.	benzimidazole	65-78	myelin oligodendrocyte glycoprotein	Homo sapiens	283-286
29593119-8	2018	Hydrophobic interactions between the molecules and HIF1alpha are also a key factor, especially the interactions between the hydrophobic groups (benzimidazole) of the molecules and the hydrophobic residues inside the binding cave.	benzimidazole	144-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-60
29459277-3	2018	Here, we describe the binding of benzimidazole-carbazole ligands to G-quadruplex structures formed in G-rich DNA sequences containing the promoter regions of human c-MYC, c-KIT1, c-KIT2, VEGF and BCL2 proto-oncogenes.	benzimidazole	33-46	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	164-169
29459277-3	2018	Here, we describe the binding of benzimidazole-carbazole ligands to G-quadruplex structures formed in G-rich DNA sequences containing the promoter regions of human c-MYC, c-KIT1, c-KIT2, VEGF and BCL2 proto-oncogenes.	benzimidazole	33-46	vascular endothelial growth factor A	Homo sapiens	187-191
29459277-3	2018	Here, we describe the binding of benzimidazole-carbazole ligands to G-quadruplex structures formed in G-rich DNA sequences containing the promoter regions of human c-MYC, c-KIT1, c-KIT2, VEGF and BCL2 proto-oncogenes.	benzimidazole	33-46	BCL2 apoptosis regulator	Homo sapiens	196-200
29407951-0	2018	Design, synthesis and biological evaluation of novel indole-benzimidazole hybrids targeting estrogen receptor alpha (ER-alpha).	benzimidazole	60-73	estrogen receptor 1	Homo sapiens	117-125
28638907-0	2017	Ruthenium(ii) p-cymene complexes of a benzimidazole-based ligand capable of VEGFR2 inhibition: hydrolysis, reactivity and cytotoxicity studies.	benzimidazole	38-51	kinase insert domain receptor	Homo sapiens	76-82
29334584-1	2018	RATIONALE: A novel benzimidazole compound ZLN005 was previously identified as a transcriptional activator of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) in certain metabolic tissues.	benzimidazole	19-32	PPARG coactivator 1 alpha	Rattus norvegicus	109-176
29334584-1	2018	RATIONALE: A novel benzimidazole compound ZLN005 was previously identified as a transcriptional activator of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) in certain metabolic tissues.	benzimidazole	19-32	PPARG coactivator 1 alpha	Rattus norvegicus	178-188
30338731-1	2018	AIM AND OBJECTIVE: The benzimidazole derivatives have been obtained via weightreducing aid (L-Carnitine) as a cheap catalyst.	benzimidazole	23-36	activation induced cytidine deaminase	Homo sapiens	87-90
29133046-3	2018	Additional Western blot analyses showed different mechanisms of cytostatic activity between compounds 10c and 11f that could be associated with the nature of aromatic substituent at 1-(1,2,3-triazolyl) and amidino moiety at C-5 position of benzimidazole ring.	benzimidazole	240-253	Rho GTPase activating protein 9	Homo sapiens	102-105
29111367-0	2017	Synthesis and biological evaluation of novel radioiodinated benzimidazole derivatives for imaging alpha-synuclein aggregates.	benzimidazole	60-73	synuclein alpha	Homo sapiens	98-113
29111367-3	2017	In order to develop imaging probes targeting alpha-syn aggregates, we synthesized and evaluated three novel radioiodinated benzimidazole (BI) derivatives for selective imaging of alpha-syn aggregates.	benzimidazole	123-136	synuclein alpha	Homo sapiens	179-188
29111367-3	2017	In order to develop imaging probes targeting alpha-syn aggregates, we synthesized and evaluated three novel radioiodinated benzimidazole (BI) derivatives for selective imaging of alpha-syn aggregates.	benzimidazole	138-140	synuclein alpha	Homo sapiens	45-54
29111367-3	2017	In order to develop imaging probes targeting alpha-syn aggregates, we synthesized and evaluated three novel radioiodinated benzimidazole (BI) derivatives for selective imaging of alpha-syn aggregates.	benzimidazole	138-140	synuclein alpha	Homo sapiens	179-188
29111367-4	2017	In binding experiments, BI-2 exhibited the highest selective binding affinity for alpha-syn aggregates among the BI derivatives.	benzimidazole	24-26	synuclein alpha	Homo sapiens	82-91
28949377-2	2017	In this study, the antiplatelet activity of three newly synthesized saccharide based benzimidazole derivatives, M3BIM, Malto-BIM and Melibio-BIM, in collagen and thrombin-stimulated human platelets in vitro was examined.	benzimidazole	85-98	coagulation factor II, thrombin	Homo sapiens	162-170
28603987-7	2017	We have thus identified the novel benzimidazole derivatives 10, 21, 27, and 30, which are highly potent AC inhibitors.	benzimidazole	34-47	N-acylsphingosine amidohydrolase 1	Homo sapiens	104-106
27602589-4	2017	The central benzimidazole ring, however, remained intact considering its great affinity toward AT1R and PPARgamma.	benzimidazole	12-25	angiotensin II receptor type 1	Homo sapiens	95-99
27602589-4	2017	The central benzimidazole ring, however, remained intact considering its great affinity toward AT1R and PPARgamma.	benzimidazole	12-25	peroxisome proliferator activated receptor gamma	Homo sapiens	104-113
28638907-3	2017	In our work, we have generated a bispyrazole-containing benzimidazole ligand with potency against vascular endothelial growth factor receptor 2 (VEGFR2), which is known to have roles in vasculogenesis/angiogenesis.	benzimidazole	56-69	kinase insert domain receptor	Homo sapiens	98-143
28638907-3	2017	In our work, we have generated a bispyrazole-containing benzimidazole ligand with potency against vascular endothelial growth factor receptor 2 (VEGFR2), which is known to have roles in vasculogenesis/angiogenesis.	benzimidazole	56-69	kinase insert domain receptor	Homo sapiens	145-151
28498655-0	2017	Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans.	benzimidazole	36-49	diacylglycerol O-acyltransferase 1	Canis lupus familiaris	50-82
28498655-0	2017	Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans.	benzimidazole	36-49	diacylglycerol O-acyltransferase 1	Canis lupus familiaris	84-89
28498655-1	2017	Modification of a gut restricted class of benzimidazole DGAT1 inhibitor 1 led to 9 with good oral bioavailability.	benzimidazole	42-55	diacylglycerol O-acyltransferase 1	Canis lupus familiaris	56-61
28137469-0	2017	Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor.	benzimidazole	43-56	cannabinoid receptor 2	Homo sapiens	120-123
28460359-0	2017	Synthesis and biological evaluation of benzimidazole derivatives as the G9a Histone Methyltransferase inhibitors that induce autophagy and apoptosis of breast cancer cells.	benzimidazole	39-52	euchromatic histone lysine methyltransferase 2	Homo sapiens	72-101
28340412-6	2017	Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives.	benzimidazole	135-150	poly(ADP-ribose) polymerase 1	Homo sapiens	66-72
28328217-4	2017	To achieve this goal, we synthesized a series of benzimidazole-based derivatives of Cl-amidine, hypothesizing that this scaffold would allow access to a series of PAD2-selective inhibitors with enhanced cellular efficacy.	benzimidazole	49-62	peptidyl arginine deiminase 2	Homo sapiens	163-167
28915607-8	2017	Moreover, the expression of the spindle checkpoint-related proteins, mitotic arrest defective 2 (Mad2), budding uninhibited in benzimidazole 1 (Bub1), and anaphase-promoting complex (APC), indicators of abnormal chromosomes and carcinogenesis, reduced in CTPE-treated BEAS-2B cells at Passage 30 compared with the vehicle control using real-time PCR and immunohistochemistry.	benzimidazole	127-140	mitotic arrest deficient 2 like 1	Homo sapiens	69-95
28915607-8	2017	Moreover, the expression of the spindle checkpoint-related proteins, mitotic arrest defective 2 (Mad2), budding uninhibited in benzimidazole 1 (Bub1), and anaphase-promoting complex (APC), indicators of abnormal chromosomes and carcinogenesis, reduced in CTPE-treated BEAS-2B cells at Passage 30 compared with the vehicle control using real-time PCR and immunohistochemistry.	benzimidazole	127-140	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	144-148
28233680-0	2017	Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/beta-catenin signaling with selectivity over effects on ATP homeostasis.	benzimidazole	0-13	catenin beta 1	Homo sapiens	68-80
28043913-3	2017	We recently identified a series of benzimidazole analogs as potent inhibitors of Wnt/beta-catenin signaling.	benzimidazole	35-48	catenin beta 1	Homo sapiens	85-97
28190654-0	2017	Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists.	benzimidazole	30-43	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	90-100
28190654-0	2017	Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists.	benzimidazole	30-43	nuclear receptor subfamily 1 group H member 4	Homo sapiens	102-105
28190654-1	2017	We describe here a novel chemotype with substituted benzimidazole scaffold for nonsteroidal farnesoid X receptor (FXR) antagonists starting from the identification of a screening hit, BB-4.	benzimidazole	52-65	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	102-112
28190654-1	2017	We describe here a novel chemotype with substituted benzimidazole scaffold for nonsteroidal farnesoid X receptor (FXR) antagonists starting from the identification of a screening hit, BB-4.	benzimidazole	52-65	nuclear receptor subfamily 1 group H member 4	Homo sapiens	114-117
28086233-0	2017	A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma.	benzimidazole	8-21	mitogen-activated protein kinase 8	Mus musculus	116-119
28138686-2	2017	Two modes of cycloaddition ([4 + 1] cycloaddition and [4 + 2] cycloaddition) occurred during condensation, causing the in situ generation of two benzimidazole derivative ligands (L1 and L3) and a quinoxaline derivative ligand (L2).	benzimidazole	145-158	immunoglobulin kappa variable 1-16	Homo sapiens	179-188
27987485-0	2017	Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors.	benzimidazole	57-70	epidermal growth factor receptor	Homo sapiens	110-114
27854075-0	2017	Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way.	benzimidazole	0-13	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	82-88
28146092-0	2017	Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives and Analogs Targeting the NLRP3 Inflammasome.	benzimidazole	45-58	NLR family pyrin domain containing 3	Homo sapiens	97-102
27923497-6	2017	Molecular docking study showed that morpholine and oxadiazole rings linked to the benzimidazole nucleus play an important role in binding with the COX-2.	benzimidazole	82-95	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	147-152
27987485-0	2017	Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors.	benzimidazole	57-70	erb-b2 receptor tyrosine kinase 2	Homo sapiens	119-124
27987485-1	2017	The synthesis of benzimidazole linked oxadiazole derivatives designed as potential EGFR and erbB2 receptor inhibitors with anticancer and apoptotic activity were studied.	benzimidazole	17-30	epidermal growth factor receptor	Homo sapiens	83-87
27987485-1	2017	The synthesis of benzimidazole linked oxadiazole derivatives designed as potential EGFR and erbB2 receptor inhibitors with anticancer and apoptotic activity were studied.	benzimidazole	17-30	erb-b2 receptor tyrosine kinase 2	Homo sapiens	92-97
27979595-2	2017	Previously reported benzimidazole CYP11B2 inhibitors led the way for bioisosteric imidazopyridines that are both potent and selective over CYP11B1.	benzimidazole	20-33	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	34-41
28197323-4	2017	Substitution at the 2-position of the azaindole ring generated somewhat less potent analogues, but reduced AO-mediated metabolism.	benzimidazole	38-47	aldehyde oxidase 1	Homo sapiens	107-109
27979595-2	2017	Previously reported benzimidazole CYP11B2 inhibitors led the way for bioisosteric imidazopyridines that are both potent and selective over CYP11B1.	benzimidazole	20-33	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	139-146
27689533-0	2016	Iodinated benzimidazole PARP radiotracer for evaluating PARP1/2 expression in vitro and in vivo.	benzimidazole	10-23	poly(ADP-ribose) polymerase 1	Homo sapiens	24-28
27930648-2	2016	The benzimidazole (BZ) drugs albendazole (ABZ) and mebendazole (MBZ) are used for treatment of human STH infections and this use is increasing dramatically with massive drug donations.	benzimidazole	4-17	saitohin	Homo sapiens	101-104
27930648-2	2016	The benzimidazole (BZ) drugs albendazole (ABZ) and mebendazole (MBZ) are used for treatment of human STH infections and this use is increasing dramatically with massive drug donations.	benzimidazole	19-21	saitohin	Homo sapiens	101-104
27689533-0	2016	Iodinated benzimidazole PARP radiotracer for evaluating PARP1/2 expression in vitro and in vivo.	benzimidazole	10-23	poly(ADP-ribose) polymerase family member 12	Homo sapiens	56-63
27677422-0	2016	Microwave-Assisted Syntheses of Benzimidazole-Containing Selenadiazole Derivatives That Induce Cell-Cycle Arrest and Apoptosis in Human Breast Cancer Cells by Activation of the ROS/AKT Pathway.	benzimidazole	32-45	AKT serine/threonine kinase 1	Homo sapiens	181-184
27560280-0	2016	Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor.	benzimidazole	69-82	cannabinoid receptor 2	Homo sapiens	146-149
27560280-2	2016	To test the hypothesis that the lack of a hydrogen bond interaction between benzimidazole and benzothiophene derivatives with Lys192 reduces their affinity for CB1 receptors (as we previously reported) and leads to CB2 selectivity, most of the tested compounds do not exhibit hydrogen bond acceptors.	benzimidazole	76-89	cannabinoid receptor 1	Homo sapiens	160-163
27560280-2	2016	To test the hypothesis that the lack of a hydrogen bond interaction between benzimidazole and benzothiophene derivatives with Lys192 reduces their affinity for CB1 receptors (as we previously reported) and leads to CB2 selectivity, most of the tested compounds do not exhibit hydrogen bond acceptors.	benzimidazole	76-89	cannabinoid receptor 2	Homo sapiens	215-218
27647702-2	2016	The use of benzimidazole as a bridging ligand at the meso position enables the binding of two BF2 units to provide sufficient rigidity and enhanced electron-withdrawing strength.	benzimidazole	11-24	forkhead box G1	Homo sapiens	94-97
27406796-0	2016	Synthesis of benzimidazole based thiadiazole and carbohydrazide conjugates as glycogen synthase kinase-3beta inhibitors with anti-depressant activity.	benzimidazole	13-26	glycogen synthase kinase 3 beta	Homo sapiens	78-108
27664806-1	2016	BACKGROUND: Budding uninhibited by benzimidazole-related 1 (BubR1), a cell cycle-related protein, is an essential component of the spindle checkpoint that regulates cell division.	benzimidazole	35-48	BUB1B, mitotic checkpoint serine/threonine kinase	Mus musculus	60-65
27561386-2	2016	BubR1 (budding uninhibited by benzimidazole-related 1) controls chromosome mitotic segregation through the spindle assembly checkpoint, and BubR1 down-regulation promotes aging-associated phenotypes.	benzimidazole	30-43	BUB1B, mitotic checkpoint serine/threonine kinase	Mus musculus	0-5
27301679-3	2016	Pyridazin-4(1H)-one derivative 1 was linked with a benzimidazole group through an alkyl spacer to interact with the OH of Tyr683 and fill the PDE10A selectivity pocket.	benzimidazole	51-64	phosphodiesterase 10A	Homo sapiens	142-148
27301679-5	2016	The crystal structure of 16f bound to PDE10A revealed that the benzimidazole moiety was located deep within the PDE10A selectivity pocket and interacted with Tyr683.	benzimidazole	63-76	phosphodiesterase 10A	Homo sapiens	38-44
27301679-5	2016	The crystal structure of 16f bound to PDE10A revealed that the benzimidazole moiety was located deep within the PDE10A selectivity pocket and interacted with Tyr683.	benzimidazole	63-76	phosphodiesterase 10A	Homo sapiens	112-118
27572707-0	2016	A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies.	benzimidazole	83-96	sucrase-isomaltase	Homo sapiens	56-73
27406796-1	2016	A series of benzimidazole based thiadiazole and carbohydrazide conjugates have been synthesized and evaluated for inhibition of glycogen synthase kinase-3beta and anti-depressant effect.	benzimidazole	12-25	glycogen synthase kinase 3 beta	Homo sapiens	128-158
27406796-2	2016	Compounds 4f, 4j, 5b, 5g and 5i were found to be the most potent inhibitors of GSK-3beta in vitro amongst the twenty-five benzimidazole based thiadiazole and carbohydrazide conjugates synthesized.	benzimidazole	122-135	glycogen synthase kinase 3 beta	Homo sapiens	79-88
27112449-4	2016	Among these, a lead compound 6a bearing a 1H-benzimidazole motif showed comparable binding affinity to MCHR1 to the corresponding imidazopyridine derivative 1.	benzimidazole	42-58	melanin-concentrating hormone receptor 1	Rattus norvegicus	103-108
27089212-4	2016	Following this approach, the interaction between triazine-benzimidazole analogues and bovine serum albumin (BSA) has been investigated with UV-Visible and fluorescence spectroscopic methods under physiological conditions.	benzimidazole	58-71	albumin	Homo sapiens	93-106
27261178-0	2016	Novel JAK1-selective benzimidazole inhibitors with enhanced membrane permeability.	benzimidazole	21-34	Janus kinase 1	Homo sapiens	6-10
27117261-1	2016	To develop non-basic melanin-concentrating hormone receptor 1 (MCHR1) antagonists with a high probability of target selectivity and therapeutic window, we explored neutral bicyclic motifs that could replace the previously reported imidazo[1,2-a]pyridine or 1H-benzimidazole motif.	benzimidazole	257-273	melanin-concentrating hormone receptor 1	Rattus norvegicus	63-68
27009905-0	2016	Plasmin inhibitors with hydrophobic amino acid-based linker between hydantoin moiety and benzimidazole scaffold enhance inhibitory activity.	benzimidazole	89-102	plasminogen	Homo sapiens	0-7
27058429-2	2016	Herein, we design a cRGD-polycarboxybetaine methacrylate-b-polybenzimidazole methacrylate (cRGD-PCB-b-PBBMZ) copolymer to self-assemble into smart drug-loaded nanoparticles (cRGD-PCM NPs) which can target alphavbeta3 integrin overexpressed cancer tissue by cRGD peptide unit and release drug quickly in cancer cells by protonation of benzimidazole groups.	benzimidazole	63-76	pyruvate carboxylase	Homo sapiens	96-99
27009905-1	2016	In this letter we report the design and synthesis of a series of plasmin inhibitors, which share the amino acid-based linker with limited free rotation between the hydantoin moiety and the benzimidazole scaffold.	benzimidazole	189-202	plasminogen	Homo sapiens	65-72
27096045-1	2016	To identify BCATm inhibitors suitable for in vivo study, Encoded Library Technology (ELT) was used to affinity screen a 117 million member benzimidazole based DNA encoded library, which identified an inhibitor series with both biochemical and cellular activities.	benzimidazole	139-152	branched chain aminotransferase 2, mitochondrial	Mus musculus	12-17
26952080-4	2016	Here, we describe a direct comparison of tetrazine ligation and strain promoted azide-alkyne cycloaddition using benzimidazole based probes to bind their known target, the gastric proton pump, ATP4A.	benzimidazole	113-126	ATPase H+/K+ transporting subunit alpha	Homo sapiens	193-198
26952080-6	2016	In addition, we have identified several novel binding partners of benzimidazole probes: Isoform 2 of deleted in malignant brain tumors 1 protein (DMBT1) and three uncharacterized proteins.	benzimidazole	66-79	ZP domain-containing protein LOC729800-like	Homo sapiens	101-144
26952080-6	2016	In addition, we have identified several novel binding partners of benzimidazole probes: Isoform 2 of deleted in malignant brain tumors 1 protein (DMBT1) and three uncharacterized proteins.	benzimidazole	66-79	ZP domain-containing protein LOC729800-like	Homo sapiens	146-151
26894559-1	2016	Benzimidazole analogs 1-27 were synthesized, characterized by EI-MS and (1)HNMR and their alpha-glucosidase inhibitory activities were found out experimentally.	benzimidazole	0-13	sucrase-isomaltase	Homo sapiens	90-107
26976506-1	2016	For finding the novel inhibitor of nuclear factor kappaB activity, a series of benzimidazole derivatives were rationally designed, synthesized and systematically studied for their in vitro activities against LPS induced NF-kappaB inhibition in RAW 264.7 cells using the SEAP assay based on the flexible chalcone JSH ((E)-1-(2-hydroxy-6-(isopentyloxy)phenyl)-3-(4-hydroxy phenyl)prop-2-en-1-one) which was previously reported.	benzimidazole	79-92	toll-like receptor 4	Mus musculus	208-211
26976506-1	2016	For finding the novel inhibitor of nuclear factor kappaB activity, a series of benzimidazole derivatives were rationally designed, synthesized and systematically studied for their in vitro activities against LPS induced NF-kappaB inhibition in RAW 264.7 cells using the SEAP assay based on the flexible chalcone JSH ((E)-1-(2-hydroxy-6-(isopentyloxy)phenyl)-3-(4-hydroxy phenyl)prop-2-en-1-one) which was previously reported.	benzimidazole	79-92	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	220-229
26878127-0	2016	Design, synthesis and molecular modeling studies of few chalcone analogues of benzimidazole for epidermal growth factor receptor inhibitor in search of useful anticancer agent.	benzimidazole	78-91	epidermal growth factor receptor	Homo sapiens	96-128
26669310-0	2016	Mibefradil represents a new class of benzimidazole TRPM7 channel agonists.	benzimidazole	37-50	transient receptor potential cation channel subfamily M member 7	Homo sapiens	51-56
26669310-8	2016	Here, we demonstrate that mibefradil and NNC 50-0396, two benzimidazole relatives of the TRPM7 inhibitor NS8593, are positive modulators of TRPM7.	benzimidazole	58-71	transient receptor potential cation channel subfamily M member 7	Homo sapiens	89-94
26669310-8	2016	Here, we demonstrate that mibefradil and NNC 50-0396, two benzimidazole relatives of the TRPM7 inhibitor NS8593, are positive modulators of TRPM7.	benzimidazole	58-71	transient receptor potential cation channel subfamily M member 7	Homo sapiens	140-145
26901666-5	2016	Thus, the newly designed benzimidazole 29g showed in vivo CRF1 receptor antagonistic activity and good brain penetration, indicating that it is a promising lead for CRF1 receptor antagonist drug discovery research.	benzimidazole	25-38	corticotropin releasing hormone receptor 1	Mus musculus	58-71
26901666-5	2016	Thus, the newly designed benzimidazole 29g showed in vivo CRF1 receptor antagonistic activity and good brain penetration, indicating that it is a promising lead for CRF1 receptor antagonist drug discovery research.	benzimidazole	25-38	corticotropin releasing hormone receptor 1	Mus musculus	165-178
26526214-1	2015	In this Letter, we report the continued optimization of the N-acyl-2-aminobenzimidazole series, focusing in particular on the N-alkyl substituent and 5-position of the benzimidazole based on the binding mode and the early SAR.	benzimidazole	74-87	sarcosine dehydrogenase	Homo sapiens	222-225
27194865-1	2016	BACKGROUND: Budding uninhibited by benzimidazole related 1 (BUBR1) is an important protein in the mitotic spindle assembly checkpoint.	benzimidazole	35-48	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	60-65
26056978-2	2015	In this work benzimidazole based metal organic thin films of dichlorobis (1H-Benzimidazole) Co(II) and dichlorobis (1H-Benzimidazole) Cu(II) were deposited by chemical bath deposition method.	benzimidazole	13-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
26088338-5	2015	Benzimidazole derivatives have shown a wide variety of pharmacological activities including PARP and DHODH inhibition.	benzimidazole	0-13	dihydroorotate dehydrogenase (quinone)	Homo sapiens	101-106
26088338-0	2015	Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH.	benzimidazole	0-13	poly(ADP-ribose) polymerase 1	Homo sapiens	59-65
25935642-1	2015	A novel series of CXCR4 antagonists with substituted piperazines as benzimidazole replacements is described.	benzimidazole	68-81	C-X-C motif chemokine receptor 4	Homo sapiens	18-23
26330080-4	2015	Three hydrazone derivatives of benzimidazole significantly increased the cellular ATP levels, reduced caspase-3 activity, reduced nitrite production and increased glucose-stimulated insulin secretion in the presence of proinflammatory cytokines.	benzimidazole	31-44	caspase 3	Homo sapiens	102-111
26330080-4	2015	Three hydrazone derivatives of benzimidazole significantly increased the cellular ATP levels, reduced caspase-3 activity, reduced nitrite production and increased glucose-stimulated insulin secretion in the presence of proinflammatory cytokines.	benzimidazole	31-44	insulin	Homo sapiens	182-189
26370442-1	2015	A new quinazoline functionalized benzimidazole-based fluorogenic chemosensor H3L is synthesized and fully characterized by conventional techniques including single crystal X-ray analysis.	benzimidazole	33-46	H3 clustered histone 2	Homo sapiens	77-80
26351728-0	2015	Benzimidazole Derivatives as Potent JAK1-Selective Inhibitors.	benzimidazole	0-13	Janus kinase 1	Homo sapiens	36-40
26351728-5	2015	A clear structure-activity relationship was observed with respect to JAK1 selectivity; this highlighted the importance of hydrogen bond donors at both N(1) and R2 positions located within a specific distance from the benzimidazole core.	benzimidazole	217-230	Janus kinase 1	Homo sapiens	69-73
26073618-0	2015	Synthesis of benzimidazole derivatives as potent beta-glucuronidase inhibitors.	benzimidazole	13-26	glucuronidase beta	Homo sapiens	49-67
26088338-0	2015	Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH.	benzimidazole	0-13	dihydroorotate dehydrogenase (quinone)	Homo sapiens	70-75
26088338-5	2015	Benzimidazole derivatives have shown a wide variety of pharmacological activities including PARP and DHODH inhibition.	benzimidazole	0-13	poly(ADP-ribose) polymerase 1	Homo sapiens	92-96
26088338-6	2015	We hereby report the design, synthesis and bioactivities of a series of benzimidazole derivatives as inhibitors of both the PARP-1 and DHODH enzymes.	benzimidazole	72-85	poly(ADP-ribose) polymerase 1	Homo sapiens	124-130
26088338-6	2015	We hereby report the design, synthesis and bioactivities of a series of benzimidazole derivatives as inhibitors of both the PARP-1 and DHODH enzymes.	benzimidazole	72-85	dihydroorotate dehydrogenase (quinone)	Homo sapiens	135-140
32689708-0	2015	Corrigendum to "Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2" [Bioorg.	benzimidazole	57-70	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	103-108
32689708-0	2015	Corrigendum to "Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2" [Bioorg.	benzimidazole	57-70	kinase insert domain receptor	Homo sapiens	113-120
26001340-0	2015	Novel 2,5-disubtituted-1,3,4-oxadiazoles with benzimidazole backbone: a new class of beta-glucuronidase inhibitors and in silico studies.	benzimidazole	46-59	glucuronidase beta	Homo sapiens	85-103
25388787-3	2015	Benzimidazole libraries were prepared using an efficient solution-phase approach and screened for inhibition of the MDM2-p53 and MDMX-p53 protein-protein interactions.	benzimidazole	0-13	MDM2 proto-oncogene	Homo sapiens	116-120
25388787-3	2015	Benzimidazole libraries were prepared using an efficient solution-phase approach and screened for inhibition of the MDM2-p53 and MDMX-p53 protein-protein interactions.	benzimidazole	0-13	tumor protein p53	Homo sapiens	121-124
25388787-3	2015	Benzimidazole libraries were prepared using an efficient solution-phase approach and screened for inhibition of the MDM2-p53 and MDMX-p53 protein-protein interactions.	benzimidazole	0-13	MDM4 regulator of p53	Homo sapiens	129-133
25388787-3	2015	Benzimidazole libraries were prepared using an efficient solution-phase approach and screened for inhibition of the MDM2-p53 and MDMX-p53 protein-protein interactions.	benzimidazole	0-13	tumor protein p53	Homo sapiens	134-137
25819489-6	2015	This effort culminated in the identification of a benzimidazole, non-glycoside SGLT2 hit with an EC50 value of 0.62 muM by high-throughput screening of 41,000 compounds.	benzimidazole	50-63	solute carrier family 5 member 2	Homo sapiens	79-84
27314076-3	2016	We found that DNA damage-induced PIDDosome formation is blocked by the mitotic checkpoint factor BUBR1 (budding uninhibited by benzimidazole-related 1), via a direct interaction that disrupts the PIDDosome core scaffold.	benzimidazole	127-140	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	97-102
25921265-3	2015	The results of the former gave us pivotal information on the further optimization of the P4 moiety in plasmin inhibitors and those of the latter revealed that appropriate moieties extending from the benzimidazole scaffold engaged with S4 pocket in the active site of plasmin.	benzimidazole	199-212	plasminogen	Homo sapiens	102-109
25921265-3	2015	The results of the former gave us pivotal information on the further optimization of the P4 moiety in plasmin inhibitors and those of the latter revealed that appropriate moieties extending from the benzimidazole scaffold engaged with S4 pocket in the active site of plasmin.	benzimidazole	199-212	plasminogen	Homo sapiens	267-274
25352112-5	2015	This review will further be helpful for the researcher on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for developing an SAR on benzimidazole drugs/compounds.	benzimidazole	175-188	sarcosine dehydrogenase	Homo sapiens	168-171
26005536-0	2015	Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.	benzimidazole	13-26	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	27-34
26039085-1	2015	The novel field-induced single-molecule magnet based on a tetracoordinate mononuclear heteroleptic Co(II) complex involving two heterocyclic benzimidazole (bzi) and two thiocyanido ligands, [Co(bzi)2(NSC)2], (CoL4), was prepared and thoroughly characterized.	benzimidazole	141-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
26039085-1	2015	The novel field-induced single-molecule magnet based on a tetracoordinate mononuclear heteroleptic Co(II) complex involving two heterocyclic benzimidazole (bzi) and two thiocyanido ligands, [Co(bzi)2(NSC)2], (CoL4), was prepared and thoroughly characterized.	benzimidazole	156-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
25847768-4	2015	Here we report the screening, synthesis and SAR studies of benzimidazole derivatives as potent inhibitors against HIV-1 replication via protecting A3G protein.	benzimidazole	59-72	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	147-150
26191374-1	2015	Benzimidazole 1 is the lead compound resulting from an antibacterial program targeting dual inhibitors of bacterial DNA gyrase and topoisomerase IV.	benzimidazole	0-13	DNA topoisomerase II alpha	Homo sapiens	116-126
26005536-1	2015	We report the discovery of a benzimidazole series of CYP11B2 inhibitors.	benzimidazole	29-42	cytochrome P450 family 11 subfamily B member 2	Macaca mulatta	53-60
25766325-0	2015	A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells.	benzimidazole	2-15	epidermal growth factor receptor	Homo sapiens	64-68
25766325-0	2015	A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells.	benzimidazole	2-15	erb-b2 receptor tyrosine kinase 2	Homo sapiens	73-77
25766325-0	2015	A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells.	benzimidazole	2-15	TNF receptor superfamily member 10b	Homo sapiens	103-106
25599839-5	2015	The synthesis, biological evaluation and SAR of novel benzimidazole derivatives as KOR agonists are described.	benzimidazole	54-67	sarcosine dehydrogenase	Homo sapiens	41-44
25415586-3	2015	However, depending on concentration, this cationic benzimidazole derivative exhibits paradoxical positive or negative effects on the phosphorylation of Akt that are not well understood.	benzimidazole	51-64	AKT serine/threonine kinase 1	Homo sapiens	152-155
25592707-0	2015	Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors.	benzimidazole	57-70	phosphodiesterase 10A	Homo sapiens	84-105
25599839-5	2015	The synthesis, biological evaluation and SAR of novel benzimidazole derivatives as KOR agonists are described.	benzimidazole	54-67	opioid receptor kappa 1	Homo sapiens	83-86
25499880-1	2015	Herein we report the identification of a highly potent and selective CB2 agonist, RQ-00202730 (40), obtained by lead optimization of the benzimidazole scaffold.	benzimidazole	137-150	cannabinoid receptor 2	Rattus norvegicus	69-72
25886260-8	2015	RESULTS: A benzimidazole derivative, named MB21, was found to be the most potent in inhibiting the cloned protease (IC50 = 5.95 muM).	benzimidazole	11-24	latexin	Homo sapiens	128-131
25641513-4	2015	These results confirm our previously reported QSAR model on benzimidazole derivatives, providing new information for the development of small molecules with high CB1 affinity.	benzimidazole	60-73	cannabinoid receptor 1	Homo sapiens	162-165
25685063-8	2015	siRNA-mediated knock-down of Noxa completely rescued benzimidazole-potentiated navitoclax activity.	benzimidazole	53-66	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	29-33
25685063-9	2015	In addition, inhibiting caspase 3 and 9 partially rescued benzimidazole-potentiated navitoclax activity.	benzimidazole	58-71	caspase 3	Homo sapiens	24-33
25748233-2	2015	identified a previously undetected participant mediating both canonical signaling, i.e., TGF-beta receptor kinase mediated, and non-canonical signaling, budding uninhibited by benzimidazole 1 (BUB1).	benzimidazole	176-189	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	193-197
25134430-0	2015	Synthesis and evaluation of benzimidazole derivatives as selective COX-2 inhibitors.	benzimidazole	28-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
25415869-3	2015	Examples are a recently discovered group II PAK (PAK4, -5, -6) selective inhibitor series based on a benzimidazole core, a group I PAK selective series based on a pyrido[2,3-d]pyrimidine-7-one core, and an allosteric dibenzodiazepine PAK1 inhibitor series.	benzimidazole	101-114	p21 (RAC1) activated kinase 4	Homo sapiens	44-47
25415869-3	2015	Examples are a recently discovered group II PAK (PAK4, -5, -6) selective inhibitor series based on a benzimidazole core, a group I PAK selective series based on a pyrido[2,3-d]pyrimidine-7-one core, and an allosteric dibenzodiazepine PAK1 inhibitor series.	benzimidazole	101-114	p21 (RAC1) activated kinase 4	Homo sapiens	49-53
25415869-3	2015	Examples are a recently discovered group II PAK (PAK4, -5, -6) selective inhibitor series based on a benzimidazole core, a group I PAK selective series based on a pyrido[2,3-d]pyrimidine-7-one core, and an allosteric dibenzodiazepine PAK1 inhibitor series.	benzimidazole	101-114	p21 (RAC1) activated kinase 4	Homo sapiens	49-52
26680714-1	2015	A molecular modeling study is performed on series of benzimidazol-based inhibitors of human dipeptidyl peptidase III (DPP III).	benzimidazole	53-65	dipeptidyl peptidase 3	Homo sapiens	92-116
26680714-1	2015	A molecular modeling study is performed on series of benzimidazol-based inhibitors of human dipeptidyl peptidase III (DPP III).	benzimidazole	53-65	dipeptidyl peptidase 3	Homo sapiens	118-125
26680714-3	2015	This study is aimed to elucidate the structural features of benzimidazole derivatives required for antagonism of human DPP III activity using Quantitative Structure-Activity Relationship (QSAR) analysis, and to understand the mechanism of one of the most potent inhibitor binding into the active site of this enzyme, by molecular dynamics (MD) simulations.	benzimidazole	60-73	dipeptidyl peptidase 3	Homo sapiens	119-126
25303727-0	2014	Design and synthesis of benzimidazole analogs endowed with oxadiazole as selective COX-2 inhibitor.	benzimidazole	24-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
25514817-0	2014	Correction to Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors.	benzimidazole	58-71	adenosine deaminase 2	Homo sapiens	90-93
25234256-4	2014	In contrast, when the imidazole groups in L(1) are replaced with benzoimidazole groups (L(3)), L(3) also yields the 4:2 complex [(L(3))4-(Zn(2+))2] at a molar ratio of 0.50.	benzimidazole	65-79	immunoglobulin kappa variable 2-14 (pseudogene)	Homo sapiens	88-92
25234256-4	2014	In contrast, when the imidazole groups in L(1) are replaced with benzoimidazole groups (L(3)), L(3) also yields the 4:2 complex [(L(3))4-(Zn(2+))2] at a molar ratio of 0.50.	benzimidazole	65-79	immunoglobulin kappa variable 2-14 (pseudogene)	Homo sapiens	95-99
25234256-4	2014	In contrast, when the imidazole groups in L(1) are replaced with benzoimidazole groups (L(3)), L(3) also yields the 4:2 complex [(L(3))4-(Zn(2+))2] at a molar ratio of 0.50.	benzimidazole	65-79	immunoglobulin kappa variable 2-14 (pseudogene)	Homo sapiens	95-99
25816587-1	2014	Specifically synthesized group of benzimidazole derivatives possessing varying degrees of delocalization of the positive charge in the cation group of the molecule has been studied in order to search for potential cholinergically active compounds and to study the role of the Coulomb interaction in cholinesterase catalysis.	benzimidazole	34-47	butyrylcholinesterase	Homo sapiens	299-313
25349648-1	2014	We report the discovery of a novel series of DGAT1 inhibitors in the benzimidazole class with a piperdinyl-oxy-cyclohexanecarboxylic acid moiety.	benzimidazole	69-82	diacylglycerol O-acyltransferase 1	Mus musculus	45-50
25255762-1	2014	The reactions of the benzimidazole nitrogen atoms and the exocyclic amino group of 2-aminobenzimidazole with CS2 in NaOH basic medium followed by methylation with methyl iodide was explored.	benzimidazole	21-34	chorionic somatomammotropin hormone 2	Homo sapiens	109-112
25082515-0	2014	Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2.	benzimidazole	41-54	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	87-92
25082515-0	2014	Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2.	benzimidazole	41-54	kinase insert domain receptor	Homo sapiens	97-104
25082515-3	2014	Among these compounds bearing quinazoline and benzimidazole fragments, compound 7j exhibited the most potent inhibitory activity against c-Met and VEGFR-2 with IC50 of 0.05muM and 0.02muM, respectively.	benzimidazole	46-59	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	137-142
25082515-3	2014	Among these compounds bearing quinazoline and benzimidazole fragments, compound 7j exhibited the most potent inhibitory activity against c-Met and VEGFR-2 with IC50 of 0.05muM and 0.02muM, respectively.	benzimidazole	46-59	kinase insert domain receptor	Homo sapiens	147-154
24992072-1	2014	Two series of novel benzimidazole derivatives were designed, synthesized and evaluated for their SIRT1 and SIRT2 inhibitory activity.	benzimidazole	20-33	sirtuin 1	Homo sapiens	97-102
24992072-1	2014	Two series of novel benzimidazole derivatives were designed, synthesized and evaluated for their SIRT1 and SIRT2 inhibitory activity.	benzimidazole	20-33	sirtuin 2	Homo sapiens	107-112
25123063-6	2014	In addition, we found that a benzimidazole-based compound known to have a binding pocket on the surface of the HIV-1 capsid prevents the binding of MxB to capsid.	benzimidazole	29-42	MX dynamin like GTPase 2	Homo sapiens	148-151
25221654-0	2014	Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors.	benzimidazole	44-57	adenosine deaminase 2	Homo sapiens	76-79
25072161-0	2014	Pharmacophore modeling, 3D-QSAR and molecular docking studies of benzimidazole derivatives as potential FXR agonists.	benzimidazole	65-78	nuclear receptor subfamily 1 group H member 4	Homo sapiens	104-107
25072161-2	2014	Atom-based three-dimensional quantitative structure activity relationship (3D-QSAR) models were developed for a series of 48 benzimidazole-based agonists of FXR.	benzimidazole	125-138	nuclear receptor subfamily 1 group H member 4	Homo sapiens	157-160
25072161-6	2014	Furthermore, molecular docking simulation was performed to understand the binding affinity of 48 benzimidazole-based compounds against the active site of human FXR protein.	benzimidazole	97-110	nuclear receptor subfamily 1 group H member 4	Homo sapiens	160-163
25072161-9	2014	Substitution effects at different positions of benzimidazole derivatives would lead to the discovery of new agonists against human FXR protein.	benzimidazole	47-60	nuclear receptor subfamily 1 group H member 4	Homo sapiens	131-134
25060336-2	2014	Periodic administration of benzimidazole drugs is the mainstay for global STH control but it does not prevent re-infection, and is unlikely to interrupt transmission as a stand-alone intervention.	benzimidazole	27-40	saitohin	Homo sapiens	74-77
25221654-1	2014	Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors.	benzimidazole	0-13	adenosine deaminase 2	Homo sapiens	62-65
24756216-1	2014	The objective of this study was to investigate the expression and clinical role of the spindle checkpoint kinase budding uninhibited by benzimidazole 1 (Bub1) in primary and metastatic advanced-stage ovarian serous carcinoma.	benzimidazole	136-149	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	153-157
24837154-0	2014	Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability.	benzimidazole	6-19	phosphodiesterase 10A	Homo sapiens	35-56
24837154-0	2014	Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability.	benzimidazole	6-19	phosphodiesterase 10A	Homo sapiens	58-64
24680957-5	2014	Modification of the substituents on the two 1H-benzimidazole groups of BBP resulted in analogues equipotent in anti-BVDV activity (EC50=0.7+-0.1muM), devoid of cytotoxicity (S.I.=142).	benzimidazole	44-60	transmembrane protein 158	Homo sapiens	71-74
24641614-0	2014	The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).	benzimidazole	10-23	arachidonate 5-lipoxygenase	Homo sapiens	109-123
24641614-0	2014	The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).	benzimidazole	10-23	arachidonate 5-lipoxygenase activating protein	Homo sapiens	144-148
24641614-2	2014	We recently identified the benzimidazole derivative BRP-7 as chemotype for anti-LT agents by virtual screening targeting 5-LOX-activating protein (FLAP).	benzimidazole	27-40	arachidonate 5-lipoxygenase activating protein	Homo sapiens	147-151
23627317-1	2014	Two series of compounds (AB and APB) bearing substituted phenoxy groups at 2-position of benzimidazole nucleus through amino or phenyleneamino were synthesized and evaluated through PASS software for predicting the activity spectrum of each compound.	benzimidazole	89-102	arginyl aminopeptidase	Homo sapiens	32-35
24665903-0	2014	A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators.	benzimidazole	17-30	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	66-70
25379167-4	2014	Furthermore, computational analysis, taken together with experimental data, provides evidence that azaindole- and indole-based attachment inhibitors bind gp120 at an accessory hydrophobic pocket beneath the CD4-binding site and can also adopt multiple unique binding modes in interacting with gp120.	benzimidazole	99-108	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	154-159
25379167-4	2014	Furthermore, computational analysis, taken together with experimental data, provides evidence that azaindole- and indole-based attachment inhibitors bind gp120 at an accessory hydrophobic pocket beneath the CD4-binding site and can also adopt multiple unique binding modes in interacting with gp120.	benzimidazole	99-108	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	293-298
24509821-5	2014	Among 27 lead interactions, the most avid interaction is between a benzimidazole (1) and precursor microRNA-96.	benzimidazole	67-80	microRNA 96	Homo sapiens	99-110
24656800-4	2014	Aminothiazole and benzimidazole derivatives were identified as novel scaffolds that bind to the catalytic triad of sEH with good ligand efficiency.	benzimidazole	18-31	epoxide hydrolase 2	Homo sapiens	115-118
24602793-7	2014	Compounds 3c &4c enhanced hPreP-mediated proteolysis of Abeta (1-42), pF1beta (2-54) and fluorogenic-substrate V. These results suggest that activation of hPreP by small benzimidazole derivatives provide a promising avenue for AD treatment.	benzimidazole	170-183	prolyl endopeptidase	Homo sapiens	26-31
24602793-7	2014	Compounds 3c &4c enhanced hPreP-mediated proteolysis of Abeta (1-42), pF1beta (2-54) and fluorogenic-substrate V. These results suggest that activation of hPreP by small benzimidazole derivatives provide a promising avenue for AD treatment.	benzimidazole	170-183	prolyl endopeptidase	Homo sapiens	155-160
25844392-10	2014	The benzimidazole microtubule/tubulin inhibitor, mebendazole complemented the anti-neoplastic cytotoxicity of gemcitabine-(C4-amide)-[anti-EGFR] in dual-combination with epirubicin-(C3-amide)-[anti-HER2/neu].	benzimidazole	4-17	epidermal growth factor receptor	Homo sapiens	139-143
25844392-10	2014	The benzimidazole microtubule/tubulin inhibitor, mebendazole complemented the anti-neoplastic cytotoxicity of gemcitabine-(C4-amide)-[anti-EGFR] in dual-combination with epirubicin-(C3-amide)-[anti-HER2/neu].	benzimidazole	4-17	erb-b2 receptor tyrosine kinase 2	Homo sapiens	198-202
25844392-12	2014	The benzimidazole tubulin/microtubule inhibitor, mebendazole also possessed anti-neoplastic cytotoxicity against chemotherapeutic-resistant mammary adenocarcinoma (SKBr-3) and complemented the potency and efficacy of gemcitabine-(C4-amide)-[anti-EGFR] in dual-combination with epirubicin-(C3-amide)-[anti-HER2/neu].	benzimidazole	4-17	epidermal growth factor receptor	Homo sapiens	246-250
25844392-12	2014	The benzimidazole tubulin/microtubule inhibitor, mebendazole also possessed anti-neoplastic cytotoxicity against chemotherapeutic-resistant mammary adenocarcinoma (SKBr-3) and complemented the potency and efficacy of gemcitabine-(C4-amide)-[anti-EGFR] in dual-combination with epirubicin-(C3-amide)-[anti-HER2/neu].	benzimidazole	4-17	erb-b2 receptor tyrosine kinase 2	Homo sapiens	305-309
24461289-0	2014	Benzimidazole CB2 agonists: design, synthesis and SAR.	benzimidazole	0-13	cannabinoid receptor 2	Homo sapiens	14-17
24587137-4	2014	Structure-activity analysis identified a core benzimidazole-phenyl-succinamide structure as being essential to inhibition of mGPDH while modifications to the benzimidazole ring system modulated both potency and off-target effects.	benzimidazole	46-59	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	125-130
24461289-0	2014	Benzimidazole CB2 agonists: design, synthesis and SAR.	benzimidazole	0-13	sarcosine dehydrogenase	Homo sapiens	50-53
24461289-1	2014	A new series of CB2-selective agonists containing a benzimidazole core is reported.	benzimidazole	52-65	cannabinoid receptor 2	Homo sapiens	16-19
24360999-3	2014	Compound 10 showed ten and eleven folds more activity than respective quinazoline and benzimidazole class of compounds with GI50 value of 1.64 muM.	benzimidazole	86-99	latexin	Homo sapiens	143-146
24387981-1	2014	A total of 15 novel benzimidazole derivatives were designed, synthesized and evaluated for their SIRT1 and SIRT2 inhibitory activity.	benzimidazole	20-33	sirtuin 1	Homo sapiens	97-102
24428639-2	2014	The most potent inhibitors in this series contained a five-membered heterocycle at the 2-position of the benzimidazole, leading to highly potent and selective compounds that exploit the differences in the size of a binding pocket adjacent to the NADPH cofactor between the bacterial and human DHFR enzymes.	benzimidazole	105-118	dihydrofolate reductase	Homo sapiens	293-297
23356363-0	2014	Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII.	benzimidazole	25-38	carbonic anhydrase 1	Homo sapiens	65-95
24387105-0	2014	Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells.	benzimidazole	32-45	aldehyde dehydrogenase 3 family member A1	Homo sapiens	10-17
24387981-1	2014	A total of 15 novel benzimidazole derivatives were designed, synthesized and evaluated for their SIRT1 and SIRT2 inhibitory activity.	benzimidazole	20-33	sirtuin 2	Homo sapiens	107-112
24392830-0	2014	Topomer CoMFA and virtual screening studies of azaindole class renin inhibitors.	benzimidazole	47-56	renin	Homo sapiens	63-68
24268539-0	2014	Design, synthesis, and enzyme kinetics of novel benzimidazole and quinoxaline derivatives as methionine synthase inhibitors.	benzimidazole	48-61	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	93-112
24268539-2	2014	Benzimidazole and deazatetrahydrofolates derivatives have been shown to inhibit methionine synthase by competing with the substrate 5-methyltetrahydrofolate.	benzimidazole	0-13	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	80-99
24392830-2	2014	In this paper, a series of azaindole class renin inhibitors were subjected to 3D-QSAR study using Topomer CoMFA.	benzimidazole	27-36	renin	Homo sapiens	43-48
24045148-3	2013	Compound III is a benzoimidazole, which has a submicromolar IC50 in both human and rat recombinant mPGES-1.	benzimidazole	18-32	prostaglandin E synthase	Mus musculus	99-106
24316668-0	2014	Discovery of a benzimidazole series of ADAMTS-5 (aggrecanase-2) inhibitors by scaffold hopping.	benzimidazole	15-28	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	39-47
24316668-0	2014	Discovery of a benzimidazole series of ADAMTS-5 (aggrecanase-2) inhibitors by scaffold hopping.	benzimidazole	15-28	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	49-62
24238902-0	2013	Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition.	benzimidazole	30-43	phosphodiesterase 10A	Homo sapiens	59-80
24238902-0	2013	Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition.	benzimidazole	30-43	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	105-111
24238902-2	2013	Introduction of an isopropyl group at the 2-position and a methoxy group at the 5-position of the benzimidazole ring of lead compound 1 resulted in the identification of 2-{[(2-isopropyl-5-methoxy-1-phenyl-1H-benzimidazol-6-yl)oxy]methyl}quinoline (25b), which exhibited potent PDE10A inhibitory activity with reduced CYP1A2 inhibitory activity compared to compound 1.	benzimidazole	98-111	phosphodiesterase 10A	Homo sapiens	278-284
24238902-2	2013	Introduction of an isopropyl group at the 2-position and a methoxy group at the 5-position of the benzimidazole ring of lead compound 1 resulted in the identification of 2-{[(2-isopropyl-5-methoxy-1-phenyl-1H-benzimidazol-6-yl)oxy]methyl}quinoline (25b), which exhibited potent PDE10A inhibitory activity with reduced CYP1A2 inhibitory activity compared to compound 1.	benzimidazole	98-111	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	318-324
24533813-9	2014	In this article benzimidazole inhibitors are reported with their mechanisms of action, structure-activity relationship (SAR) and biological properties.	benzimidazole	16-29	sarcosine dehydrogenase	Homo sapiens	87-124
24120542-3	2013	Extensive optimization resulted in azaindole 26 (Cdc7 IC50=1.1 nM, pMCM2 IC50=32 nM) that demonstrated robust lowering of pMCM2 in a mouse pharmacodynamic (PD) model when dosed orally.	benzimidazole	35-44	cell division cycle 7 (S. cerevisiae)	Mus musculus	49-53
24288780-1	2013	Benzimidazole and their metal analogs that can act as multimodal agent and have non-peptidic CCK-B receptor antagonist were synthesized and characterized on the basis of spectroscopic techniques such as FT-IR, NMR, FAB-MS and also evaluated for biologic efficacy.	benzimidazole	0-13	cholecystokinin B receptor	Rattus norvegicus	93-107
24689236-0	2013	[Synthesis and activity evaluation of PARP-1 inhibitors with azaindole skeleton].	benzimidazole	61-70	poly(ADP-ribose) polymerase 1	Homo sapiens	38-44
24260527-10	2013	The benzylvanillin alone (Bn1) has weak anticancer activity even after it was combined with the benzimidazole (2MP), but after addition of another benzylvanillin structure (2XP), stronger activity was observed.	benzimidazole	96-109	C-C motif chemokine receptor 6	Homo sapiens	26-29
24121339-0	2013	Crystal structure of a complex of human chymase with its benzimidazole derived inhibitor.	benzimidazole	57-70	chymase 1	Homo sapiens	40-47
24121339-1	2013	The crystal structure of human chymase complexed with a novel benzimidazole inhibitor, TJK002, was determined at 2.8 A resolution.	benzimidazole	62-75	chymase 1	Homo sapiens	31-38
24121339-2	2013	The X-ray crystallographic study shows that the benzimidazole inhibitor forms a non-covalent interaction with the catalytic domain of human chymase.	benzimidazole	48-61	chymase 1	Homo sapiens	140-147
23981529-0	2013	Synthesis and antiproliferative evaluation of novel benzoimidazole-contained oxazole-bridged analogs of combretastatin A-4.	benzimidazole	52-66	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	119-122
24936240-1	2013	A de novo hit-to-lead effort involving the redesign of benzimidazole-containing antagonists of the CXCR4 receptor resulted in the discovery of a novel series of 1,2,3,4-tetrahydroisoquinoline (TIQ) analogues.	benzimidazole	55-68	C-X-C motif chemokine receptor 4	Homo sapiens	99-104
23810496-1	2013	A series of benzimidazole derivatives with a phenylcyclohexyl acetic acid group as DGAT-1 inhibitors was developed.	benzimidazole	12-25	diacylglycerol O-acyltransferase 1	Homo sapiens	83-89
23891231-0	2013	Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors.	benzimidazole	65-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	97-117
23763627-2	2013	Changing the two benzimidazole groups of the DDDD unit to triazole groups replaces two of the NH   N hydrogen bonds with CH   N interactions (complex [5 6]), but only reduces the association constant in CH3CN by 2 orders of magnitude (K(a) = 2.6 x 10(4) M(-1) in CH3CN; K(a) > 1 x 10(7) M(-1) in CH2Cl2).	benzimidazole	17-30	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	45-49
23544603-5	2013	In the present review, benzimidazole derivatives with different pharmacological activities are described on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for the development of SAR on benzimidazoles for each activity.	benzimidazole	23-36	sarcosine dehydrogenase	Homo sapiens	223-226
23805983-1	2013	The chlorotropy observed by NMR in this study occurred by the rapid intermolecular transfer of a chloro group between 1-chlorobenzimidazole and benzimidazole in CCl4/CH3OH/K2CO3 solution.	benzimidazole	126-139	C-C motif chemokine ligand 4	Homo sapiens	161-165
23886696-0	2013	Synthesis, characterization, and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors.	benzimidazole	69-82	butyrylcholinesterase	Homo sapiens	98-112
23886696-1	2013	Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containing benzimidazole core structure were synthesized by a four-step reaction pathway starting from 4-fluoro-3-nitrobenzoic acid as the basic compound.	benzimidazole	103-116	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-40
23886696-1	2013	Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containing benzimidazole core structure were synthesized by a four-step reaction pathway starting from 4-fluoro-3-nitrobenzoic acid as the basic compound.	benzimidazole	103-116	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-46
23886696-1	2013	Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containing benzimidazole core structure were synthesized by a four-step reaction pathway starting from 4-fluoro-3-nitrobenzoic acid as the basic compound.	benzimidazole	103-116	butyrylcholinesterase	Homo sapiens	52-73
23886696-1	2013	Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containing benzimidazole core structure were synthesized by a four-step reaction pathway starting from 4-fluoro-3-nitrobenzoic acid as the basic compound.	benzimidazole	103-116	butyrylcholinesterase	Homo sapiens	75-79
23743277-1	2013	Benzimidazole and indane are the two key fragments in our potent and selective MCH-1 receptor (MCHR1) antagonists.	benzimidazole	0-13	melanin concentrating hormone receptor 1	Homo sapiens	95-100
23713567-2	2013	Using structure activity analysis, we established that the benzimidazole moiety at C-17 is essential and optimal and also that hydrophilic and heteroaromatic groups at C-3 enhance both antiproliferative (AP) and AR degrading (ARD) activities.	benzimidazole	59-72	cytokine like 1	Homo sapiens	83-87
23481650-3	2013	Synthesis of focused indole and azaindole analogs yielded potent and selective 5-azaindole Cdc7 inhibitors with improved intrinsic metabolic stability (ie 36).	benzimidazole	32-41	cell division cycle 7	Homo sapiens	91-95
23815580-5	2013	In the present review, benzimidazole derivatives with different pharmacological activities are described on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for the development of SAR on benzimidazoles for each activity.	benzimidazole	23-36	sarcosine dehydrogenase	Homo sapiens	223-226
24900745-0	2013	Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety.	benzimidazole	31-44	diacylglycerol O-acyltransferase 1	Mus musculus	7-12
24900745-1	2013	We report the design and synthesis of a series of novel DGAT1 inhibitors in the benzimidazole class with a pyridyl-oxy-cyclohexanecarboxylic acid moiety.	benzimidazole	80-93	diacylglycerol O-acyltransferase 1	Mus musculus	56-61
23629894-0	2013	Two one-dimensional coordination polymers generated from a new benzimidazole bridging ligand and CdX2 (X = Br and I).	benzimidazole	63-76	RE1 silencing transcription factor	Homo sapiens	103-115
23525274-1	2013	A conceptually new and general strategy has been developed for the construction of a benzimidazole or a benzoxazole ring fused with isoquinolinone affording a diverse and unique class of small molecules as potential and novel inhibitors of PDE4.	benzimidazole	85-98	phosphodiesterase 4A	Homo sapiens	240-244
23392733-1	2013	BUBR1 (budding uninhibited by benzimidazole-related 1) represents the component of a controlling complex in mitosis.	benzimidazole	30-43	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	0-5
23440991-2	2013	The budding uninhibited by benzimidazole 1 (BUB1) gene is a highly conserved protein that plays a critical role at the spindle assembly checkpoint during cell division.	benzimidazole	27-40	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	44-48
23360431-5	2013	A predictive model was developed from the initial SAR in which the potency of the analogues correlated with the ability of the substituent in the 7-position of the azaindole to adopt a coplanar conformation by either forming internal hydrogen bonds or avoiding repulsive substitution patterns.	benzimidazole	164-173	sarcosine dehydrogenase	Homo sapiens	50-53
22946527-0	2013	Synthesis, p38 kinase inhibitory and anti-inflammatory activity of new substituted benzimidazole derivatives.	benzimidazole	83-96	mitogen-activated protein kinase 14	Homo sapiens	11-14
22812394-3	2013	In this study, we prepared a group of Co(II)-pbzim complexes that bear variable numbers of both positive charges and benzimidazole (bzim) groups.	benzimidazole	117-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
22812394-3	2013	In this study, we prepared a group of Co(II)-pbzim complexes that bear variable numbers of both positive charges and benzimidazole (bzim) groups.	benzimidazole	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
23438747-3	2013	Using a high-throughput chemical screen, we identified a benzimidazole compound, wALADin1, that selectively targets the delta-aminolevulinic acid dehydratase (ALAD) of Wolbachia (wALAD) and exhibits macrofilaricidal effects on Wolbachia-containing filarial worms in vitro.	benzimidazole	57-70	aminolevulinate dehydratase	Homo sapiens	120-157
23438747-3	2013	Using a high-throughput chemical screen, we identified a benzimidazole compound, wALADin1, that selectively targets the delta-aminolevulinic acid dehydratase (ALAD) of Wolbachia (wALAD) and exhibits macrofilaricidal effects on Wolbachia-containing filarial worms in vitro.	benzimidazole	57-70	aminolevulinate dehydratase	Homo sapiens	82-86
24900653-0	2013	Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195.	benzimidazole	0-9	cell division cycle 7	Homo sapiens	30-34
24900653-2	2013	X-ray cocrystallization using a surrogate protein, GSK3beta, and modeling studies confirmed the azaindole motif as the hinge binder.	benzimidazole	96-105	glycogen synthase kinase 3 beta	Homo sapiens	51-59
24155042-4	2012	Based on these findings, we designed and synthesized new PPARgamma ligands with a benzimidazole (agonists 4-5 and 4-6), benzothiophene (agonists 5-5 and 5-6) or benzofuran (agonists 6-5 and 6-6) moiety either at position 5 or 6 of the benzimidazole core structure.	benzimidazole	82-95	peroxisome proliferator activated receptor gamma	Mus musculus	57-66
23206862-0	2013	Identification of a novel benzimidazole derivative as a highly potent NPY Y5 receptor antagonist with an anti-obesity profile.	benzimidazole	26-39	neuropeptide Y receptor Y5	Mus musculus	70-85
23026385-0	2012	Docking investigation and binding interaction of benzimidazole derivative with bovine serum albumin.	benzimidazole	49-62	albumin	Homo sapiens	86-99
23025998-0	2012	Identification of a novel and orally available benzimidazole derivative as an NPY Y5 receptor antagonist with in vivo efficacy.	benzimidazole	47-60	neuropeptide Y receptor Y5	Homo sapiens	78-93
23141914-0	2012	Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors.	benzimidazole	31-44	diacylglycerol O-acyltransferase 1	Homo sapiens	60-90
23141914-1	2012	A novel series of benzimidazole derivatives was prepared and evaluated for their diacylglycerol acyltransferase (DGAT) inhibitory activity using microsome from rat liver.	benzimidazole	18-31	diacylglycerol O-acyltransferase 1	Rattus norvegicus	81-111
23141914-1	2012	A novel series of benzimidazole derivatives was prepared and evaluated for their diacylglycerol acyltransferase (DGAT) inhibitory activity using microsome from rat liver.	benzimidazole	18-31	diacylglycerol O-acyltransferase 1	Rattus norvegicus	113-117
23058106-0	2012	Benzimidazole inhibitors of the protein kinase CHK2: clarification of the binding mode by flexible side chain docking and protein-ligand crystallography.	benzimidazole	0-13	checkpoint kinase 2	Homo sapiens	47-51
23058106-1	2012	Two closely related binding modes have previously been proposed for the ATP-competitive benzimidazole class of checkpoint kinase 2 (CHK2) inhibitors; however, neither binding mode is entirely consistent with the reported SAR.	benzimidazole	88-101	checkpoint kinase 2	Homo sapiens	111-130
23058106-1	2012	Two closely related binding modes have previously been proposed for the ATP-competitive benzimidazole class of checkpoint kinase 2 (CHK2) inhibitors; however, neither binding mode is entirely consistent with the reported SAR.	benzimidazole	88-101	checkpoint kinase 2	Homo sapiens	132-136
23058106-1	2012	Two closely related binding modes have previously been proposed for the ATP-competitive benzimidazole class of checkpoint kinase 2 (CHK2) inhibitors; however, neither binding mode is entirely consistent with the reported SAR.	benzimidazole	88-101	sarcosine dehydrogenase	Homo sapiens	221-224
23058106-2	2012	Unconstrained rigid docking of benzimidazole ligands into representative CHK2 protein crystal structures reveals an alternative binding mode involving a water-mediated interaction with the hinge region; docking which incorporates protein side chain flexibility for selected residues in the ATP binding site resulted in a refinement of the water-mediated hinge binding mode that is consistent with observed SAR.	benzimidazole	31-44	checkpoint kinase 2	Homo sapiens	73-77
23058106-2	2012	Unconstrained rigid docking of benzimidazole ligands into representative CHK2 protein crystal structures reveals an alternative binding mode involving a water-mediated interaction with the hinge region; docking which incorporates protein side chain flexibility for selected residues in the ATP binding site resulted in a refinement of the water-mediated hinge binding mode that is consistent with observed SAR.	benzimidazole	31-44	sarcosine dehydrogenase	Homo sapiens	406-409
23058106-3	2012	The flexible docking results are in good agreement with the crystal structures of four exemplar benzimidazole ligands bound to CHK2 which unambiguously confirmed the binding mode of these inhibitors, including the water-mediated interaction with the hinge region, and which is significantly different from binding modes previously postulated in the literature.	benzimidazole	96-109	checkpoint kinase 2	Homo sapiens	127-131
24155042-4	2012	Based on these findings, we designed and synthesized new PPARgamma ligands with a benzimidazole (agonists 4-5 and 4-6), benzothiophene (agonists 5-5 and 5-6) or benzofuran (agonists 6-5 and 6-6) moiety either at position 5 or 6 of the benzimidazole core structure.	benzimidazole	235-248	peroxisome proliferator activated receptor gamma	Mus musculus	57-66
22564276-0	2012	Novel benzimidazole analogs as inhibitors of EGFR tyrosine kinase.	benzimidazole	6-19	epidermal growth factor receptor	Homo sapiens	45-49
22854224-0	2012	Antioxidant benzimidazole bind bovine serum albumin.	benzimidazole	12-25	albumin	Homo sapiens	38-51
22519452-0	2012	Modulation of PAR(1)  signalling by benzimidazole compounds.	benzimidazole	36-49	Prader Willi/Angelman region RNA 1	Homo sapiens	14-20
22921743-8	2012	Two inhibitors are benzimidazole-like compounds that reversibly and competitively inhibit human DDAH-1 with Ligand Efficiency values >=0.3 kcal/mol/heavy (non-hydrogen) atom, indicating their suitability for further development.	benzimidazole	19-32	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	96-102
22877085-2	2012	Using a structure-based design approach, we have identified a series of potent and selective benzimidazole-based inhibitors of PI3Kdelta.	benzimidazole	93-106	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	127-136
22853998-0	2012	Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles.	benzimidazole	46-59	neuropeptide Y receptor Y5	Homo sapiens	89-104
22519452-11	2012	CONCLUSIONS AND IMPLICATIONS: The Q94 and Q109 benzimidazole derivatives represent a novel scaffold for the development of new PAR(1)  inhibitors and provide a starting point to develop dual signalling pathway-selective positive/negative modulators of PAR(1) .	benzimidazole	47-60	Prader Willi/Angelman region RNA 1	Homo sapiens	127-133
22801646-1	2012	The lead optimization of a series of potent azaindole IKK2 inhibitors is described.	benzimidazole	44-53	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	54-58
22519452-11	2012	CONCLUSIONS AND IMPLICATIONS: The Q94 and Q109 benzimidazole derivatives represent a novel scaffold for the development of new PAR(1)  inhibitors and provide a starting point to develop dual signalling pathway-selective positive/negative modulators of PAR(1) .	benzimidazole	47-60	Prader Willi/Angelman region RNA 1	Homo sapiens	252-258
22863183-0	2012	Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin.	benzimidazole	45-58	albumin	Homo sapiens	110-123
22863183-4	2012	The interaction evaluation of compound 11d with bovine serum albumin (BSA) by Fluorescence and UV-vis absorption spectroscopic method showed that BSA could generate fluorescent quenching under approximately human physiological conditions by the prepared benzimidazole compound 11d as result of the formation of ground-state compound 11d-BSA complex.	benzimidazole	254-267	albumin	Homo sapiens	55-68
24900520-0	2012	Substituted benzimidazole and imidazopyridine compounds useful as cyp17 modulators: patent highlight.	benzimidazole	12-25	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	66-71
22765895-4	2012	Through targeted SAR and structure-guided design, new imidazopyridine and imidazopyridazine scaffolds were identified that demonstrated superior inhibition of mTOR in cellular assays, selectivity over the closely related PIKK family and improved in vivo clearance over our previously reported benzimidazole series.	benzimidazole	293-306	sarcosine dehydrogenase	Homo sapiens	17-20
22765895-4	2012	Through targeted SAR and structure-guided design, new imidazopyridine and imidazopyridazine scaffolds were identified that demonstrated superior inhibition of mTOR in cellular assays, selectivity over the closely related PIKK family and improved in vivo clearance over our previously reported benzimidazole series.	benzimidazole	293-306	mechanistic target of rapamycin kinase	Homo sapiens	159-163
22357520-2	2012	To understand how telmisartan partially activates PPARgamma, we determined the ternary complex structure of PPARgamma, telmisartan, and a coactivator peptide from steroid receptor coactivator-1 at a resolution of 2.18 A. Crystallographic analysis revealed that telmisartan exhibits an unexpected binding mode in which the central benzimidazole ring is engaged in a non-canonical--and suboptimal--hydrogen-bonding network around helix 12 (H12).	benzimidazole	330-343	peroxisome proliferator activated receptor gamma	Homo sapiens	108-117
22481174-2	2012	The mutual interaction of this benzimidazole derivative (MBTBI) with bovine serum albumin (BSA) was investigated using solution spectral studies.	benzimidazole	31-44	albumin	Homo sapiens	76-95
22127612-8	2012	Concurrently, we identified several unique binding features of benzimidazole derivatives and showed that alkoxy-substituents of the benzimidazole ring are located within a FPR1 hole bounded by Thr199, Thr265, Ile268, and Leu271 or in a groove in the vicinity of Leu198, Arg201, Gly202, and Arg205.	benzimidazole	63-76	formyl peptide receptor 1	Homo sapiens	172-176
22607880-0	2012	Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP).	benzimidazole	24-37	arachidonate 5-lipoxygenase	Homo sapiens	123-137
22607880-0	2012	Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP).	benzimidazole	24-37	arachidonate 5-lipoxygenase activating protein	Homo sapiens	158-162
22127612-8	2012	Concurrently, we identified several unique binding features of benzimidazole derivatives and showed that alkoxy-substituents of the benzimidazole ring are located within a FPR1 hole bounded by Thr199, Thr265, Ile268, and Leu271 or in a groove in the vicinity of Leu198, Arg201, Gly202, and Arg205.	benzimidazole	132-145	formyl peptide receptor 1	Homo sapiens	172-176
22127612-9	2012	The understanding of these molecular features will likely prove beneficial in future design of novel FPR1 agonists based on the benzimidazole scaffold.	benzimidazole	128-141	formyl peptide receptor 1	Homo sapiens	101-105
24900459-1	2012	A novel series of benzimidazole designed multiple ligands (DMLs) with activity at the neuronal nitric oxide synthase (nNOS) enzyme and the mu-opioid receptor was developed.	benzimidazole	18-31	nitric oxide synthase 1	Homo sapiens	86-116
22464457-0	2012	In silico binding free energy predictability with pi-pi interaction energy-augmented scoring function: benzimidazole Raf inhibitors as a case study.	benzimidazole	103-116	zinc fingers and homeoboxes 2	Homo sapiens	117-120
22268420-1	2012	One pharmacophore model and three quantitative structure-activity relationship models were developed on a series of benzimidazole and imidazole inhibitors of histone deacetylase 2.	benzimidazole	116-129	histone deacetylase 2	Homo sapiens	158-179
22530898-0	2012	Synthesis and beta-glucuronidase inhibitory potential of benzimidazole derivatives.	benzimidazole	57-70	glucuronidase beta	Homo sapiens	14-32
22530898-1	2012	Benzimidazole derivatives 1-24 have been synthesized and their in vitro beta-glucuronidase inhibitory activitiy was evaluated.	benzimidazole	0-13	glucuronidase beta	Homo sapiens	72-90
22237832-2	2012	Benzimidazole forming ring closure was enabled under microwave irradiation in the presence of 10% TFA/DCE.	benzimidazole	0-13	24-dehydrocholesterol reductase	Homo sapiens	102-105
22524426-0	2012	Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kbeta inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers.	benzimidazole	34-47	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	86-94
22524426-0	2012	Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kbeta inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers.	benzimidazole	34-47	phosphatase and tensin homolog	Homo sapiens	127-159
22524426-0	2012	Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kbeta inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers.	benzimidazole	34-47	phosphatase and tensin homolog	Homo sapiens	161-165
22524426-3	2012	Herein we describe the discovery and optimization of a new series of benzimidazole- and benzoxazole-pyrimidones as small molecular mass PI3Kbeta-selective inhibitors.	benzimidazole	69-82	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	136-144
22856146-3	2012	Several potential benzimidazole--plant FtsZ protein binding sites were identified.	benzimidazole	18-31	Tubulin/FtsZ family protein	Arabidopsis thaliana	39-43
22366657-0	2012	A novel series of benzimidazole NR2B-selective NMDA receptor antagonists.	benzimidazole	18-31	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	32-36
24900459-1	2012	A novel series of benzimidazole designed multiple ligands (DMLs) with activity at the neuronal nitric oxide synthase (nNOS) enzyme and the mu-opioid receptor was developed.	benzimidazole	18-31	nitric oxide synthase 1	Homo sapiens	118-122
22204908-1	2012	The newly synthesized benzimidazole compounds were suggested to be inhibitors of Plasmodium falciparum plasmepsin II and human cathepsin D by virtual screening of an internal library of synthetic compounds.	benzimidazole	22-35	cathepsin D	Homo sapiens	127-138
21724404-0	2011	Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors.	benzimidazole	13-26	epidermal growth factor receptor	Homo sapiens	61-65
22119126-2	2012	The benzimidazole (L) crystallizes in the space group P2(1)/c with a = 8.6660(3) A, b = 16.6739(7) A, c = 9.8611(4) A and beta = 113.505(3)   and forms an infinite chain structure with a trans-zigzag type along the crystallographic axis "a", through the intermolecular H-bond.	benzimidazole	4-17	H3 histone pseudogene 16	Homo sapiens	54-59
23109848-0	2012	A combination of 3D-QSAR, molecular docking and molecular dynamics simulation studies of benzimidazole-quinolinone derivatives as iNOS inhibitors.	benzimidazole	89-102	nitric oxide synthase 2	Homo sapiens	130-134
23109848-2	2012	In previous studies, a series of benzimidazole-quinolinone derivatives with high inhibitory activity against human iNOS were discovered.	benzimidazole	33-46	nitric oxide synthase 2	Homo sapiens	115-119
21723881-5	2011	In contrast, several novel benzimidazole openers showed selectivity for KCNQ2/3 and KCNQ2 and retain activity at KCNQ2(W236L).	benzimidazole	27-40	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	72-79
21723881-5	2011	In contrast, several novel benzimidazole openers showed selectivity for KCNQ2/3 and KCNQ2 and retain activity at KCNQ2(W236L).	benzimidazole	27-40	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	72-77
21723881-5	2011	In contrast, several novel benzimidazole openers showed selectivity for KCNQ2/3 and KCNQ2 and retain activity at KCNQ2(W236L).	benzimidazole	27-40	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	84-89
21820945-0	2011	Synthesis and interaction studies of benzimidazole derivative with human serum albumin.	benzimidazole	37-50	albumin	Homo sapiens	73-86
21798739-0	2011	Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARgamma partial agonist.	benzimidazole	53-66	peroxisome proliferator activated receptor gamma	Homo sapiens	67-76
21798739-2	2011	A novel benzimidazole series of centrally penetrant PPARgamma partial agonists has been identified.	benzimidazole	8-21	peroxisome proliferator activated receptor gamma	Homo sapiens	52-61
21724404-0	2011	Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors.	benzimidazole	13-26	kinase insert domain receptor	Homo sapiens	67-74
21724404-0	2011	Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors.	benzimidazole	13-26	platelet derived growth factor receptor beta	Homo sapiens	79-84
21724404-2	2011	In this work, we used two virtual screening methods, support vector machines (SVM) and molecular docking, to identify a novel series of benzimidazole derivatives, 2-aryl benzimidazole compounds, as multi-target EGFR, VEGFR-2 and PDGFR inhibitors.	benzimidazole	136-149	epidermal growth factor receptor	Homo sapiens	211-215
21724404-2	2011	In this work, we used two virtual screening methods, support vector machines (SVM) and molecular docking, to identify a novel series of benzimidazole derivatives, 2-aryl benzimidazole compounds, as multi-target EGFR, VEGFR-2 and PDGFR inhibitors.	benzimidazole	136-149	kinase insert domain receptor	Homo sapiens	217-224
21724404-2	2011	In this work, we used two virtual screening methods, support vector machines (SVM) and molecular docking, to identify a novel series of benzimidazole derivatives, 2-aryl benzimidazole compounds, as multi-target EGFR, VEGFR-2 and PDGFR inhibitors.	benzimidazole	136-149	platelet derived growth factor receptor beta	Homo sapiens	229-234
21724404-7	2011	Our study discovered a novel series of benzimidazole derivatives as multi-target EGFR, VEGFR-2 and PDGFR kinases inhibitors.	benzimidazole	39-52	epidermal growth factor receptor	Homo sapiens	81-85
21724404-7	2011	Our study discovered a novel series of benzimidazole derivatives as multi-target EGFR, VEGFR-2 and PDGFR kinases inhibitors.	benzimidazole	39-52	kinase insert domain receptor	Homo sapiens	87-94
21724404-7	2011	Our study discovered a novel series of benzimidazole derivatives as multi-target EGFR, VEGFR-2 and PDGFR kinases inhibitors.	benzimidazole	39-52	platelet derived growth factor receptor beta	Homo sapiens	99-104
21319800-2	2011	The benzimidazole derivative AKT inhibitor-IV (ChemBridge 5233705) affects this pathway and exhibits potent anticancer and antiviral activity.	benzimidazole	4-17	AKT serine/threonine kinase 1	Homo sapiens	29-32
21669533-1	2011	A series of benzimidazole CB(2) receptor agonists were prepared and their properties investigated.	benzimidazole	12-25	cannabinoid receptor 2	Rattus norvegicus	26-40
20607332-3	2011	In this work, molecular modeling and QSAR studies of a set of 30 compounds, indole and benzimidazole derivatives, as H(4)R antagonists were performed.	benzimidazole	87-100	histamine receptor H4	Homo sapiens	117-122
20697761-0	2011	3D-QSAR and molecular docking studies of azaindole derivatives as Aurora B kinase inhibitors.	benzimidazole	41-50	aurora kinase B	Homo sapiens	66-74
20697761-2	2011	Recently a series of azaindole derivatives with Aurora B inhibitory activities were reported.	benzimidazole	21-30	aurora kinase B	Homo sapiens	48-56
20697761-3	2011	To explore the relationship between the structures of substituted azaindole derivatives and their inhibition of Aurora B, 3D-QSAR and molecular docking studies were performed on a dataset of 41 compounds.	benzimidazole	66-75	aurora kinase B	Homo sapiens	112-120
21366329-0	2011	Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship.	benzimidazole	0-13	NIMA related kinase 2	Homo sapiens	100-104
21481591-0	2011	2-Arylbenzothiazole, benzoxazole and benzimidazole derivatives as fluorogenic substrates for the detection of nitroreductase and aminopeptidase activity in clinically important bacteria.	benzimidazole	37-50	carboxypeptidase Q	Homo sapiens	129-143
21130741-6	2011	Telmisartan has a unique binding mode to the AT1 receptor due to its distal benzimidazole portion.	benzimidazole	76-89	angiotensin II receptor type 1	Homo sapiens	45-57
21269824-0	2011	Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties.	benzimidazole	33-46	nuclear receptor subfamily 1, group H, member 4	Mus musculus	75-78
21185722-2	2011	The SAR leading to the identification of the optimal azaindole regioisomer as well as the pharmacokinetics and off-target activities of the most potent antagonists are disclosed.	benzimidazole	53-62	sarcosine dehydrogenase	Homo sapiens	4-7
21128593-0	2011	Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists.	benzimidazole	27-40	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	52-93
21128593-0	2011	Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists.	benzimidazole	27-40	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	95-100
21128593-3	2011	The design, synthesis, and optimization of a class of selective TRPM8 antagonists based on a benzimidazole scaffold is described, leading to the identification of compounds that exhibited potent antagonism of TRPM8 in cell-based functional assays for human, rat, and canine TRPM8 channels.	benzimidazole	93-106	transient receptor potential cation channel subfamily M member 8	Homo sapiens	64-69
21128593-3	2011	The design, synthesis, and optimization of a class of selective TRPM8 antagonists based on a benzimidazole scaffold is described, leading to the identification of compounds that exhibited potent antagonism of TRPM8 in cell-based functional assays for human, rat, and canine TRPM8 channels.	benzimidazole	93-106	transient receptor potential cation channel subfamily M member 8	Homo sapiens	209-214
21128593-3	2011	The design, synthesis, and optimization of a class of selective TRPM8 antagonists based on a benzimidazole scaffold is described, leading to the identification of compounds that exhibited potent antagonism of TRPM8 in cell-based functional assays for human, rat, and canine TRPM8 channels.	benzimidazole	93-106	transient receptor potential cation channel subfamily M member 8	Canis lupus familiaris	209-214
20951033-1	2010	A novel class of benzimidazole NPY Y5 receptor antagonists was prepared exploiting a privileged spirocarbamate moiety.	benzimidazole	17-30	neuropeptide Y receptor Y5	Rattus norvegicus	31-46
21144757-0	2011	Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25.	benzimidazole	58-71	cyclin dependent kinase 5	Homo sapiens	92-96
21144757-0	2011	Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25.	benzimidazole	58-71	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	97-100
21220496-10	2011	These data suggest that benzimidazole IGF-1R/InsR inhibitors may select for upregulation and be effluxed by the ATP-binding cassette transporter, BCRP, contributing to resistance.	benzimidazole	24-37	insulin like growth factor 1 receptor	Homo sapiens	38-44
21220496-10	2011	These data suggest that benzimidazole IGF-1R/InsR inhibitors may select for upregulation and be effluxed by the ATP-binding cassette transporter, BCRP, contributing to resistance.	benzimidazole	24-37	insulin receptor	Homo sapiens	45-49
21220496-10	2011	These data suggest that benzimidazole IGF-1R/InsR inhibitors may select for upregulation and be effluxed by the ATP-binding cassette transporter, BCRP, contributing to resistance.	benzimidazole	24-37	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	146-150
21220496-0	2011	Drug efflux by breast cancer resistance protein is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924.	benzimidazole	84-97	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	15-47
21067921-0	2010	Discovery of new azaindole-based PI3Kalpha inhibitors: apoptotic and antiangiogenic effect on cancer cells.	benzimidazole	17-26	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	33-42
21067921-3	2010	By varying groups at the 3,5-positions of azaindole, we developed the SAR (Structure-activity relationship) and identified a series of potent PI3Kalpha inhibitors.	benzimidazole	42-51	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	142-151
20937029-0	2010	Substituted benzimidazole derivatives as angiotensin II-AT1 receptor antagonist: a review.	benzimidazole	12-25	angiotensinogen	Homo sapiens	41-55
20937029-10	2010	Research efforts for development of new molecules with similar structural features have led to the discovery of various non-peptidic Ang II receptor antagonists with different substituted heterocyclic such as imidazole (losartan) and benzimidazole (candesartan and telmisartan).	benzimidazole	234-247	angiotensinogen	Homo sapiens	133-139
20937029-11	2010	In this study we have critically reviewed various benzimidazole substituted compounds as Ang II-AT(1) receptor antagonists and explored other potential clinical uses for this class of compounds.	benzimidazole	50-63	angiotensinogen	Homo sapiens	89-95
20965737-1	2010	In a prior communication we identified a novel class of benzimidazole-based inhibitors of EGF-induced phosphorylation of ERK5.	benzimidazole	56-69	mitogen-activated protein kinase 7	Homo sapiens	121-125
20933412-1	2010	A series of potent, benzimidazole-based SCD inhibitors which demonstrate selectivity for the hSCD1 enzyme over the hSCD5 isoform are described.	benzimidazole	20-33	stearoyl-CoA desaturase	Homo sapiens	40-43
20933412-1	2010	A series of potent, benzimidazole-based SCD inhibitors which demonstrate selectivity for the hSCD1 enzyme over the hSCD5 isoform are described.	benzimidazole	20-33	stearoyl-CoA desaturase	Homo sapiens	93-98
20965737-2	2010	In this paper we examine the biological activity of several 1-isopropyl-4-amino-6-ether linked benzimidazole-based compounds for their ability to selectively inhibit EGF-mediated ERK5 phosphorylation; potential utility of variation at the 6-position was indicated by the initial structural feature survey.	benzimidazole	95-108	mitogen-activated protein kinase 7	Homo sapiens	179-183
20933412-1	2010	A series of potent, benzimidazole-based SCD inhibitors which demonstrate selectivity for the hSCD1 enzyme over the hSCD5 isoform are described.	benzimidazole	20-33	stearoyl-CoA desaturase 5	Homo sapiens	115-120
20153189-0	2010	SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors.	benzimidazole	30-43	sarcosine dehydrogenase	Homo sapiens	0-3
20642456-10	2010	We synthesized five elaborated benzimidazole compounds and characterized their binding to PNMT, showing for the first time how this class of inhibitors interact with the noradrenaline-binding site.	benzimidazole	31-44	phenylethanolamine N-methyltransferase	Homo sapiens	90-94
20660191-8	2010	Moreover, LANA associated with another kinetochore protein, Bub1 (budding uninhibited by benzimidazole 1), which is known to form a complex with CENP-F.	benzimidazole	89-102	LANA	Human gammaherpesvirus 8	10-14
20660191-8	2010	Moreover, LANA associated with another kinetochore protein, Bub1 (budding uninhibited by benzimidazole 1), which is known to form a complex with CENP-F.	benzimidazole	89-102	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	60-64
20660191-8	2010	Moreover, LANA associated with another kinetochore protein, Bub1 (budding uninhibited by benzimidazole 1), which is known to form a complex with CENP-F.	benzimidazole	89-102	centromere protein F	Homo sapiens	145-151
20724156-2	2010	The synthesis and biological evaluation of novel benzimidazole derivatives as MCHR1 antagonists are described.	benzimidazole	49-62	melanin concentrating hormone receptor 1	Homo sapiens	78-83
20174844-1	2010	Novel classes of cannabinoid 2 receptor (CB2) agonists based on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole scaffolds have shown high binding affinity toward CB2 receptor and good selectivity over cannabinoid 1 receptor (CB1).	benzimidazole	107-120	cannabinoid receptor 2	Homo sapiens	171-174
20174844-1	2010	Novel classes of cannabinoid 2 receptor (CB2) agonists based on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole scaffolds have shown high binding affinity toward CB2 receptor and good selectivity over cannabinoid 1 receptor (CB1).	benzimidazole	107-120	cannabinoid receptor 1	Homo sapiens	210-232
20174844-1	2010	Novel classes of cannabinoid 2 receptor (CB2) agonists based on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole scaffolds have shown high binding affinity toward CB2 receptor and good selectivity over cannabinoid 1 receptor (CB1).	benzimidazole	107-120	cannabinoid receptor 1	Homo sapiens	234-237
20649571-0	2010	2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase.	benzimidazole	59-72	mitogen-activated protein kinase 8	Homo sapiens	174-197
20545947-1	2010	From an azaindole lead, identified in high throughput screen, a series of potent bis-azaindole inhibitors of IGF1-R have been synthesized using rational drug design and SAR based on a in silico binding mode hypothesis.	benzimidazole	8-17	insulin like growth factor 1 receptor	Homo sapiens	109-115
20545947-1	2010	From an azaindole lead, identified in high throughput screen, a series of potent bis-azaindole inhibitors of IGF1-R have been synthesized using rational drug design and SAR based on a in silico binding mode hypothesis.	benzimidazole	8-17	sarcosine dehydrogenase	Homo sapiens	169-172
20484153-0	2010	Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands.	benzimidazole	79-92	histamine receptor H4	Homo sapiens	121-142
20875744-1	2010	In this study, the benzimidazole derivatives were synthesized and evaluated as imaging agents for the NR2B subtype of NMDA receptor.	benzimidazole	19-32	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	102-106
20828702-3	2010	Based on the chromatographic behaviors for the resolution of PPI analogues on CSP 1, a chiral recognition mechanism utilizing the sulfoxide oxygen and the benzimidazole ring nitrogen of PPIs as bidentate coordination donors to form an enantioselective ternary complex with the central Cu(II) ion and the chiral stationary bidentate ligand was proposed.	benzimidazole	155-168	regulator of calcineurin 1	Homo sapiens	78-83
20174844-0	2010	CoMFA and CoMSIA analyses on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole derivatives as selective CB2 receptor agonists.	benzimidazole	72-85	cannabinoid receptor 2	Homo sapiens	111-114
20174844-1	2010	Novel classes of cannabinoid 2 receptor (CB2) agonists based on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole scaffolds have shown high binding affinity toward CB2 receptor and good selectivity over cannabinoid 1 receptor (CB1).	benzimidazole	107-120	cannabinoid receptor 2	Homo sapiens	17-39
20174844-1	2010	Novel classes of cannabinoid 2 receptor (CB2) agonists based on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole scaffolds have shown high binding affinity toward CB2 receptor and good selectivity over cannabinoid 1 receptor (CB1).	benzimidazole	107-120	cannabinoid receptor 2	Homo sapiens	41-44
21579212-1	2010	In the title salt, C(18)H(19)N(4)O(+) PF(6) (-), the dihedral angle between the benzimidazolium and benzimidazole ring systems is 16.24 (2) .	benzimidazole	100-113	sperm associated antigen 17	Homo sapiens	38-43
20379528-1	2010	A coordination polymer, [Co(II)(bIM)(acetate)] (bIM = benzimidazole) was synthesized using a solvothermal method; the complex has a two dimensional non-interpenetrated network structure and exhibits a spin-canted antiferromagnetic behaviour at low temperature and a high coercive field.	benzimidazole	54-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
20379528-1	2010	A coordination polymer, [Co(II)(bIM)(acetate)] (bIM = benzimidazole) was synthesized using a solvothermal method; the complex has a two dimensional non-interpenetrated network structure and exhibits a spin-canted antiferromagnetic behaviour at low temperature and a high coercive field.	benzimidazole	54-67	BCL2 like 11	Homo sapiens	32-35
20379528-1	2010	A coordination polymer, [Co(II)(bIM)(acetate)] (bIM = benzimidazole) was synthesized using a solvothermal method; the complex has a two dimensional non-interpenetrated network structure and exhibits a spin-canted antiferromagnetic behaviour at low temperature and a high coercive field.	benzimidazole	54-67	BCL2 like 11	Homo sapiens	48-51
20185309-0	2010	Benzimidazole Thumb Pocket I finger-loop inhibitors of HCV NS5B polymerase: improved drug-like properties through C-2 SAR in three sub-series.	benzimidazole	0-13	complement C2	Homo sapiens	114-117
20185309-0	2010	Benzimidazole Thumb Pocket I finger-loop inhibitors of HCV NS5B polymerase: improved drug-like properties through C-2 SAR in three sub-series.	benzimidazole	0-13	sarcosine dehydrogenase	Homo sapiens	118-121
20185309-1	2010	SAR at the C-2 position of benzimidazole-based Thumb Pocket I inhibitors of HCV NS5B polymerase revealed parallel activity for distinct sub-series that harbor 5-hydroxytryptophan amides, neutral thiazole isosteres or recently disclosed cinnamic acid diamides.	benzimidazole	27-40	sarcosine dehydrogenase	Homo sapiens	0-3
20185309-1	2010	SAR at the C-2 position of benzimidazole-based Thumb Pocket I inhibitors of HCV NS5B polymerase revealed parallel activity for distinct sub-series that harbor 5-hydroxytryptophan amides, neutral thiazole isosteres or recently disclosed cinnamic acid diamides.	benzimidazole	27-40	complement C2	Homo sapiens	11-14
20153189-0	2010	SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors.	benzimidazole	30-43	nuclear receptor subfamily 1 group I member 2	Homo sapiens	7-10
20153189-0	2010	SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors.	benzimidazole	30-43	insulin like growth factor 1 receptor	Homo sapiens	50-56
20078106-6	2010	This combined experimental and computational study has permitted to propose the molecular mechanisms by which the new benzimidazole derivatives act as 5-HT(6)R antagonists.	benzimidazole	118-131	5-hydroxytryptamine receptor 6	Homo sapiens	151-159
20073471-2	2010	On the basis of these findings and docking pose similarity between telmisartan and rosiglitazone in PPAR gamma active site, two classes of benzimidazole derivatives were designed and synthesized as dual PPAR gamma agonist/angiotensin II antagonists for the possible treatment of metabolic syndrome.	benzimidazole	139-152	peroxisome proliferator activated receptor gamma	Homo sapiens	203-213
20073471-2	2010	On the basis of these findings and docking pose similarity between telmisartan and rosiglitazone in PPAR gamma active site, two classes of benzimidazole derivatives were designed and synthesized as dual PPAR gamma agonist/angiotensin II antagonists for the possible treatment of metabolic syndrome.	benzimidazole	139-152	angiotensinogen	Homo sapiens	222-236
20078106-0	2010	Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists.	benzimidazole	0-13	5-hydroxytryptamine receptor 6	Homo sapiens	33-57
20073471-2	2010	On the basis of these findings and docking pose similarity between telmisartan and rosiglitazone in PPAR gamma active site, two classes of benzimidazole derivatives were designed and synthesized as dual PPAR gamma agonist/angiotensin II antagonists for the possible treatment of metabolic syndrome.	benzimidazole	139-152	peroxisome proliferator activated receptor gamma	Homo sapiens	100-110
20042333-0	2010	Benzimidazole- and indole-substituted 1,3"-bipyrrolidine benzamides as histamine H3 receptor antagonists.	benzimidazole	0-13	histamine receptor H3	Homo sapiens	71-92
20055427-3	2010	Efforts to enhance the inhibitory potency of the initial purine series of fructose-1,6-bisphosphatase (FBPase) inhibitors led to the discovery of a series of benzimidazole analogues with human FBPase IC(50)s < 100 nM.	benzimidazole	158-171	fructose-bisphosphatase 2	Rattus norvegicus	103-109
20055427-3	2010	Efforts to enhance the inhibitory potency of the initial purine series of fructose-1,6-bisphosphatase (FBPase) inhibitors led to the discovery of a series of benzimidazole analogues with human FBPase IC(50)s < 100 nM.	benzimidazole	158-171	fructose-bisphosphatase 2	Rattus norvegicus	193-199
20082612-11	2010	CONCLUSIONS AND IMPLICATIONS: These results demonstrate that XK1 and XK2 are effective neuroprotective agents in vitro and indicate that 5-substituted benzimidazole derivatives inhibit GluN1/GluN2B receptors via direct binding to the ATD of the GluN2B subunit.	benzimidazole	151-164	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	185-190
20082612-11	2010	CONCLUSIONS AND IMPLICATIONS: These results demonstrate that XK1 and XK2 are effective neuroprotective agents in vitro and indicate that 5-substituted benzimidazole derivatives inhibit GluN1/GluN2B receptors via direct binding to the ATD of the GluN2B subunit.	benzimidazole	151-164	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	191-197
20082612-11	2010	CONCLUSIONS AND IMPLICATIONS: These results demonstrate that XK1 and XK2 are effective neuroprotective agents in vitro and indicate that 5-substituted benzimidazole derivatives inhibit GluN1/GluN2B receptors via direct binding to the ATD of the GluN2B subunit.	benzimidazole	151-164	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	245-251
20110603-1	2010	We describe the interactions of two benzimidazole derivatives, astemizole (AST) and lansoprazole (LNS), with anomalous aggregates of tau protein (neurofibrillary tangles).	benzimidazole	36-49	microtubule associated protein tau	Homo sapiens	133-136
19433063-0	2009	A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathway.	benzimidazole	8-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-76
19769332-4	2009	Systematic replacement of each of the unfused carbon atoms in the phenyl ring of the indole moiety by a nitrogen atom provided four different azaindole derivatives that displayed a clear SAR for antiviral activity and all of which displayed marked improvements in pharmaceutical properties.	benzimidazole	142-151	sarcosine dehydrogenase	Homo sapiens	187-190
19888760-0	2009	Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents.	benzimidazole	67-80	poly (ADP-ribose) polymerase family, member 1	Mus musculus	87-116
19888760-0	2009	Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents.	benzimidazole	67-80	poly (ADP-ribose) polymerase family, member 1	Mus musculus	118-124
19888760-2	2009	As one of the strategies to expand our portfolio of PARP-1 inhibitors, we pursued unsaturated heterocycles to replace the saturated cyclic amine derivatives appended to the benzimidazole core.	benzimidazole	173-186	poly (ADP-ribose) polymerase family, member 1	Mus musculus	52-58
19716296-1	2009	SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides as novel inhibitors of the hedgehog pathway.	benzimidazole	58-71	sarcosine dehydrogenase	Homo sapiens	0-3
20014869-2	2009	The synthesis and characterization of a novel polycyclic azaindole based derivative is disclosed, and its binding to JAK2 is described.	benzimidazole	57-66	Janus kinase 2	Homo sapiens	117-121
19632115-3	2009	Structure-based design employing an active site homology model derived from PKA led to the preparation of benzimidazole 5-substituted compounds 26 and 27 as highly potent inhibitors (K(i) <1nM) of p70S6K, with >100-fold selectivity against PKA, ROCK and GSK3.	benzimidazole	106-119	ribosomal protein S6 kinase B1	Homo sapiens	200-206
19540111-2	2009	Systematic modification of benzimidazole lead 5a identified from a high-throughput screening led to the discovery of a potent and metabolically stable glucokinase activator 16p(R) with greater structural diversity from GKAs reported to date.	benzimidazole	27-40	glucokinase	Rattus norvegicus	151-162
19433063-2	2009	We report the novel benzimidazole analogue AC1-004, obtained from a chemical library using an HRE-dependent cell-based assay in colorectal carcinoma HCT-116 cells.	benzimidazole	20-33	long intergenic non-protein coding RNA 1587	Homo sapiens	43-50
19433063-7	2009	These results suggest the benzimidazole analogue AC1-004 is a novel HIF inhibitor that targets HIF-1alpha via the Hsp90-Akt pathway, and that it can be used as a new lead in developing anticancer drugs.	benzimidazole	26-39	long intergenic non-protein coding RNA 1587	Homo sapiens	49-56
19433063-7	2009	These results suggest the benzimidazole analogue AC1-004 is a novel HIF inhibitor that targets HIF-1alpha via the Hsp90-Akt pathway, and that it can be used as a new lead in developing anticancer drugs.	benzimidazole	26-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-105
19433063-7	2009	These results suggest the benzimidazole analogue AC1-004 is a novel HIF inhibitor that targets HIF-1alpha via the Hsp90-Akt pathway, and that it can be used as a new lead in developing anticancer drugs.	benzimidazole	26-39	AKT serine/threonine kinase 1	Homo sapiens	120-123
19119060-1	2009	Seven transition metal complexes of benzimidazole ligand (HL) are reported and characterized based on elemental analyses, IR, solid reflectance, magnetic moment, molar conductance and thermal analyses (TGA and DTA).	benzimidazole	36-49	T-box transcription factor 1	Homo sapiens	202-205
19398200-0	2009	Optimization of benzimidazole series as opioid receptor-like 1 (ORL1) antagonists: SAR study directed toward improvement of selectivity over hERG activity.	benzimidazole	16-29	opioid related nociceptin receptor 1	Homo sapiens	40-62
19398200-0	2009	Optimization of benzimidazole series as opioid receptor-like 1 (ORL1) antagonists: SAR study directed toward improvement of selectivity over hERG activity.	benzimidazole	16-29	opioid related nociceptin receptor 1	Homo sapiens	64-68
19398200-0	2009	Optimization of benzimidazole series as opioid receptor-like 1 (ORL1) antagonists: SAR study directed toward improvement of selectivity over hERG activity.	benzimidazole	16-29	ETS transcription factor ERG	Homo sapiens	141-145
19398200-1	2009	A structure-activity relationship (SAR) study on the benzimidazole series of opioid receptor-like 1 (ORL1) antagonists related to 1 is described.	benzimidazole	53-66	opioid related nociceptin receptor 1	Homo sapiens	77-99
19398200-1	2009	A structure-activity relationship (SAR) study on the benzimidazole series of opioid receptor-like 1 (ORL1) antagonists related to 1 is described.	benzimidazole	53-66	opioid related nociceptin receptor 1	Homo sapiens	101-105
19327988-1	2009	The indole ring systems of the cytosolic phospholipase A(2)alpha (cPLA(2)alpha) inhibitor 1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid (2) and the isomeric 6-carboxylic acid (3) were replaced by benzimidazole, benzotriazole and indazole scaffolds, respectively.	benzimidazole	209-222	phospholipase A2 group IVA	Homo sapiens	66-78
19307115-0	2009	Discovery of potent and selective DP1 receptor antagonists in the azaindole series.	benzimidazole	66-75	transcription factor Dp-1	Homo sapiens	34-37
19307115-1	2009	Azaindole based structures were evaluated as DP1 receptor antagonists.	benzimidazole	0-9	transcription factor Dp-1	Homo sapiens	45-48
19929839-3	2009	Pyrazole and azaindole fragment hits with micromolar activity were rapidly progressed to nanomolar inhibitors of PKB with activity in cells using crystallographic analysis of inhibitor binding modes to guide medicinal chemistry.	benzimidazole	13-22	protein tyrosine kinase 2 beta	Homo sapiens	113-116
19143569-1	2009	We have developed a series of cyclic amine-containing benzimidazole carboxamide PARP inhibitors with a methyl-substituted quaternary center at the point of attachment to the benzimidazole ring system.	benzimidazole	54-67	poly(ADP-ribose) polymerase 1	Homo sapiens	80-84
18586490-0	2008	Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent.	benzimidazole	59-72	sarcosinemia autosomal recessive	Mus musculus	14-17
18574696-3	2008	An Aurora A high throughput screen revealed a promising sub-micromolar indazole-benzimidazole lead.	benzimidazole	80-93	aurora kinase A	Homo sapiens	3-11
18819794-0	2008	Itk kinase inhibitors: initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead.	benzimidazole	105-118	IL2 inducible T cell kinase	Homo sapiens	0-3
18819794-1	2008	Previously, we reported a series of novel benzimidazole based Itk inhibitors that exhibited excellent enzymatic potency and selectivity but low microsomal stability.	benzimidazole	42-55	IL2 inducible T cell kinase	Homo sapiens	62-65
18819799-1	2008	A series of novel potent benzimidazole based inhibitors of interleukin-2 T-cell kinase (Itk) were prepared.	benzimidazole	25-38	IL2 inducible T cell kinase	Homo sapiens	59-86
18819799-1	2008	A series of novel potent benzimidazole based inhibitors of interleukin-2 T-cell kinase (Itk) were prepared.	benzimidazole	25-38	IL2 inducible T cell kinase	Homo sapiens	88-91
18763755-1	2008	We previously reported that 1 (BMS-536924), a benzimidazole inhibitor of the insulin-like growth factor-1 receptor, had demonstrated in vivo antitumor activity.	benzimidazole	46-59	insulin like growth factor 1 receptor	Homo sapiens	77-114
18541433-1	2008	We have developed a series of cyclic amine-containing benzimidazole carboxamide poly(ADP-ribose)polymerase (PARP) inhibitors, with good PARP-1 enzyme potency, as well as cellular potency.	benzimidazole	54-67	poly (ADP-ribose) polymerase family, member 1	Mus musculus	80-106
18541433-1	2008	We have developed a series of cyclic amine-containing benzimidazole carboxamide poly(ADP-ribose)polymerase (PARP) inhibitors, with good PARP-1 enzyme potency, as well as cellular potency.	benzimidazole	54-67	poly (ADP-ribose) polymerase family, member 1	Mus musculus	108-112
18541433-1	2008	We have developed a series of cyclic amine-containing benzimidazole carboxamide poly(ADP-ribose)polymerase (PARP) inhibitors, with good PARP-1 enzyme potency, as well as cellular potency.	benzimidazole	54-67	poly (ADP-ribose) polymerase family, member 1	Mus musculus	136-142
18586490-0	2008	Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent.	benzimidazole	59-72	poly (ADP-ribose) polymerase family, member 1	Mus musculus	87-114
18586490-0	2008	Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent.	benzimidazole	59-72	poly (ADP-ribose) polymerase family, member 1	Mus musculus	116-120
18976926-0	2008	Synthesis and biological activities of novel nonpeptide angiotensin II receptor antagonists based on benzimidazole derivatives bearing a heterocyclic ring.	benzimidazole	101-114	angiotensinogen	Homo sapiens	56-70
18006194-6	2008	Our analysis suggests that stabilizing interactions between the halogen atom at the benzimidazole ring and the Ser-122 of the D(2)-like and Trp-358 of the 5-HT(1A) receptor.	benzimidazole	84-97	5-hydroxytryptamine receptor 1A	Homo sapiens	155-172
18572407-0	2008	Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors.	benzimidazole	50-63	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-35
18572407-0	2008	Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors.	benzimidazole	50-63	insulin like growth factor 1 receptor	Homo sapiens	70-76
18586490-3	2008	Utilizing a benzimidazole carboxamide scaffold in which the amide forms a key intramolecular hydrogen bond for optimal interaction with the enzyme, we have identified a novel series of PARP inhibitors containing a quaternary methylene-amino substituent at the C-2 position of the benzimidazole.	benzimidazole	12-25	poly (ADP-ribose) polymerase family, member 1	Mus musculus	185-189
18522867-0	2008	Novel benzimidazole derivatives as selective CB2 agonists.	benzimidazole	6-19	cannabinoid receptor 2	Homo sapiens	45-48
18539028-0	2008	Discovery of potent, orally active benzimidazole glucagon receptor antagonists.	benzimidazole	35-48	glucagon receptor	Mus musculus	49-66
18522867-1	2008	The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported.	benzimidazole	75-88	cannabinoid receptor 2	Homo sapiens	51-54
18394887-1	2008	A novel series of benzimidazole CB2-receptor agonists was synthesized and the structure-activity relationship explored.	benzimidazole	18-31	cannabinoid receptor 2	Rattus norvegicus	32-44
18468891-0	2008	Identification of novel benzimidazole series of potent and selective ORL1 antagonists.	benzimidazole	24-37	opioid related nociceptin receptor 1	Homo sapiens	69-73
18468891-1	2008	Structure-activity studies on benzimidazole lead 1 obtained from library screening led to the discovery of potent and selective ORL1 antagonist 28, 5-chloro-2-[(1-ethyl-1-methylpropyl)thio]-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1H-benzimidazole, which is structurally distinct from conventional non-peptide antagonists known to date.	benzimidazole	30-43	opioid related nociceptin receptor 1	Homo sapiens	128-132
18192899-7	2008	The SNPs 200Tyr, 167Tyr in beta-tubulin isotype 1 have been described to confer benzimidazole resistance in nematodes and recently 198Ala has also been associated with benzimidazole resistance.	benzimidazole	80-93	beta-tubulin	Ovis aries	27-39
18346892-0	2008	Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors.	benzimidazole	40-53	dipeptidyl peptidase 4	Homo sapiens	69-92
18346892-1	2008	A novel series of non-covalent, benzimidazole-based inhibitors of DPP-4 has been developed from a small fragment hit using structure-based drug design.	benzimidazole	32-45	dipeptidyl peptidase 4	Homo sapiens	66-71
18242988-0	2008	Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3.	benzimidazole	28-41	C-X-C motif chemokine receptor 3	Homo sapiens	80-85
18242988-2	2008	Systematic modification of the benzimidazole core and tethered acetophenone moiety established tractable SAR of analogs with improved physicochemical properties and sub-micromolar activity across both human and murine receptors.	benzimidazole	31-44	sarcosine dehydrogenase	Homo sapiens	105-108
18065684-4	2008	Using this system, we have screened more than 8000 compounds in the DIVERSet chemical library for repressors of a matrix metalloproteinase-9 (MMP-9) promoter and identified 5-methyl-2-(4-methylphenyl)-1H-benzimidazole (MPBD) inhibitory for MMP-9 gene expression.	benzimidazole	201-217	matrix metallopeptidase 9	Homo sapiens	142-147
18207395-3	2008	N-methylation of the benzimidazole moiety within the lead structure significantly reduced P-gp susceptibility while increasing potency, giving rise to good brain penetration.	benzimidazole	21-34	phosphoglycolate phosphatase	Homo sapiens	90-94
18343620-2	2008	The development of high performance liquid chromatography method on amylose-based stationary phases (Chiralpak AD) has permitted to achieve the preparative enantioseparation of one benzimidazole derivative, potent-AMP-kinase (AMPK) activator with satisfactory yields.	benzimidazole	181-194	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	207-224
18343620-2	2008	The development of high performance liquid chromatography method on amylose-based stationary phases (Chiralpak AD) has permitted to achieve the preparative enantioseparation of one benzimidazole derivative, potent-AMP-kinase (AMPK) activator with satisfactory yields.	benzimidazole	181-194	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	226-230
18192899-7	2008	The SNPs 200Tyr, 167Tyr in beta-tubulin isotype 1 have been described to confer benzimidazole resistance in nematodes and recently 198Ala has also been associated with benzimidazole resistance.	benzimidazole	168-181	beta-tubulin	Ovis aries	27-39
18192899-9	2008	These genetic analyses indicate that there is a correlation between exposure and/or resistance to MLs and an increase in the frequency of the beta-tubulin alleles containing codons, which are determinant for benzimidazole resistance.	benzimidazole	208-221	beta-tubulin	Ovis aries	142-154
18036341-3	2008	The budding uninhibited by benzimidazole (Bub1) is a key component of mitotic checkpoint.	benzimidazole	27-40	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	42-46
17676829-3	2007	The SAR results were also supported by the X-ray crystallographic elucidation of the role of the N1 nitrogen and the urea moiety when the benzimidazole-urea compounds were bound to the VEGFR-2 enzyme.	benzimidazole	138-151	kinase insert domain receptor	Homo sapiens	185-192
17937984-1	2007	A series of benzimidazole compounds containing pendant alcohol and amine moieties was found to be active against checkpoint kinase Chk2.	benzimidazole	12-25	checkpoint kinase 2	Homo sapiens	131-135
18791270-3	2008	METHODS: We analyzed the mRNA expression levels of the major mitotic checkpoint genes of the budding uninhibited by benzimidazole family (BUB1, BUBR1, BUB3) and of the MAD gene family (MAD1, MAD2L1, MAD2L2) by real-time quantitative PCR in 39 ccRCC and in 36 normal kidney tissue samples.	benzimidazole	116-129	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	138-142
17934515-7	2007	Only the kinases TRK und FLT3 were inhibited by azaindole 1 in the sub-micromolar range, albeit with IC50 values of 252 and 303 nM, respectively.	benzimidazole	48-57	Fms related receptor tyrosine kinase 3	Rattus norvegicus	25-29
17576060-1	2007	Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity.	benzimidazole	24-37	tankyrase	Homo sapiens	0-6
17499505-0	2007	Hit-to-lead studies on benzimidazole inhibitors of ITK: discovery of a novel class of kinase inhibitors.	benzimidazole	23-36	IL2 inducible T cell kinase	Homo sapiens	51-54
17482821-1	2007	We have prepared a set of heterocyclic benzimidazole derivatives bearing amidino substituents at C-5 of benzimidazole ring, by introducing various heterocyclic nuclei (pyridine, N-methyl-pyrrole or imidazole) at C-2, and evaluated their antitumor and antiviral activities.	benzimidazole	39-52	complement C5	Homo sapiens	97-100
17368898-1	2007	Two different benzimidazole analogues act as multimodal agent, first one as novel non-peptidic CCK-B receptor antagonist and similarly as potent anti-fungal agent, designated as [Bz-Im].	benzimidazole	14-27	cholecystokinin B receptor	Rattus norvegicus	95-109
17482821-1	2007	We have prepared a set of heterocyclic benzimidazole derivatives bearing amidino substituents at C-5 of benzimidazole ring, by introducing various heterocyclic nuclei (pyridine, N-methyl-pyrrole or imidazole) at C-2, and evaluated their antitumor and antiviral activities.	benzimidazole	39-52	complement C2	Homo sapiens	212-215
17482821-1	2007	We have prepared a set of heterocyclic benzimidazole derivatives bearing amidino substituents at C-5 of benzimidazole ring, by introducing various heterocyclic nuclei (pyridine, N-methyl-pyrrole or imidazole) at C-2, and evaluated their antitumor and antiviral activities.	benzimidazole	104-117	complement C5	Homo sapiens	97-100
17416530-0	2007	Inhibition of monoamine oxidase B by selected benzimidazole and caffeine analogues.	benzimidazole	46-59	monoamine oxidase B	Homo sapiens	14-33
17416530-3	2007	In the present study, we have prepared additional caffeine and benzimidazole analogues in an attempt to identify compounds with improved MAO-B inhibition potency while still acting reversibly.	benzimidazole	63-76	monoamine oxidase B	Homo sapiens	137-142
17416530-5	2007	The most potent inhibitor among the benzimidazole analogues was (E)-2-(4-trifluoromethylstyryl)-1-methylbenzimidazole with a K(i) value of 430 nM.	benzimidazole	36-49	cystatin 12, pseudogene	Homo sapiens	64-69
17178222-0	2007	Quinazoline and benzimidazole MCH-1R antagonists.	benzimidazole	16-29	melanin concentrating hormone receptor 1	Homo sapiens	30-36
17419606-3	2007	A similar, but weaker effect was also observed when using a benzimidazole-phenoxazine derivative as Pgp inhibitor.	benzimidazole	60-73	phosphoglycolate phosphatase	Homo sapiens	100-103
17274763-5	2007	In haptocorrin, it provides hydrophobic contacts to the benzimidazole moiety through the apolar regions of Arg357, Trp359 and Tyr362.	benzimidazole	56-69	transcobalamin 1	Homo sapiens	3-14
16513356-0	2006	Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators.	benzimidazole	39-52	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	75-103
18193694-1	2007	The following paper addresses an attempt to determine the trace levels of two benzimidazole fungicides (carbendazim, CAS 10605-21-7 and thiabendazole, CAS 148-79-8) in drinking water samples using the newly proposed linear modulated stochastic resonance algorithm.	benzimidazole	78-91	BCAR1 scaffold protein, Cas family member	Homo sapiens	117-120
18193694-1	2007	The following paper addresses an attempt to determine the trace levels of two benzimidazole fungicides (carbendazim, CAS 10605-21-7 and thiabendazole, CAS 148-79-8) in drinking water samples using the newly proposed linear modulated stochastic resonance algorithm.	benzimidazole	78-91	BCAR1 scaffold protein, Cas family member	Homo sapiens	151-154
16904318-0	2006	Novel benzimidazole-based MCH R1 antagonists.	benzimidazole	6-19	melanin concentrating hormone receptor 1	Homo sapiens	26-32
16904318-1	2006	The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists.	benzimidazole	95-108	melanin concentrating hormone receptor 1	Homo sapiens	25-31
16904318-1	2006	The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists.	benzimidazole	95-108	melanin concentrating hormone receptor 1	Homo sapiens	115-121
16690315-2	2006	Novel benzimidazole analogues with increased chemical stability, devoid of the potential carcinogenic liability associated with a biarylamine moiety, were synthesized and evaluated to be potent MCH R1 antagonists.	benzimidazole	6-19	melanin concentrating hormone receptor 1	Homo sapiens	194-200
17209555-4	2007	Analogously, adding the equivalent of N-3 to low-fidelity benzimidazole-derived bases (i.e., bases that pol alpha rapidly incorporates opposite all four natural bases) and to generate 1-deazapurines significantly strengthens the ability of pol alpha to identify the resulting 1-deazapurines as wrong.	benzimidazole	58-71	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	104-113
17209555-4	2007	Analogously, adding the equivalent of N-3 to low-fidelity benzimidazole-derived bases (i.e., bases that pol alpha rapidly incorporates opposite all four natural bases) and to generate 1-deazapurines significantly strengthens the ability of pol alpha to identify the resulting 1-deazapurines as wrong.	benzimidazole	58-71	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	240-249
16760428-3	2006	We show that Plk1 binds to budding uninhibited by benzimidazole 1 (Bub1) in mitotic human cells.	benzimidazole	50-63	polo like kinase 1	Homo sapiens	13-17
16760428-3	2006	We show that Plk1 binds to budding uninhibited by benzimidazole 1 (Bub1) in mitotic human cells.	benzimidazole	50-63	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	67-71
16513356-1	2006	Design, synthesis and structure-activity relationships of benzimidazole derivatives as activators of the AMP-activated protein kinase (AMPK) are presented in this paper.	benzimidazole	58-71	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	105-133
16513356-1	2006	Design, synthesis and structure-activity relationships of benzimidazole derivatives as activators of the AMP-activated protein kinase (AMPK) are presented in this paper.	benzimidazole	58-71	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	135-139
16563760-2	2006	Benzimidazole and indazolone derivatives prepared retained good potency in vitro and indazolone 4a was identified as a novel TRPV1 receptor antagonist suitable for evaluating orally in animal models of analgesia.	benzimidazole	0-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	125-130
16789735-0	2006	Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic.	benzimidazole	7-20	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	33-64
16789735-2	2006	An X-ray cocrystal structure of inhibitor 46/PTP1B at 1.8 A resolution demonstrated that the benzimidazole sulfonamides form a bidentate H bond to Asp48 as designed, although the aryl group of the sulfonamide unexpectedly interacts intramolecularly in a pi-stacking manner with the benzimidazole.	benzimidazole	93-106	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	45-50
16700898-6	2006	Pantoprazole and tenatoprazole, a novel proton pump inhibitor which has an imidazopyridine ring in place of the benzimidazole moiety found in other proton pump inhibitors, are activated more slowly than other proton pump inhibitors but their inhibition is resistant to reversal.	benzimidazole	112-125	ATPase H+/K+ transporting subunit alpha	Homo sapiens	40-51
16700898-8	2006	The chemical and pharmacological characteristics of tenatoprazole give it theoretical advantages over benzimidazole-based proton pump inhibitors that should translate into improved acid control, particularly during the night.	benzimidazole	102-115	ATPase H+/K+ transporting subunit alpha	Homo sapiens	122-133
16039125-0	2005	Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists.	benzimidazole	57-70	angiotensinogen	Homo sapiens	84-98
16442290-2	2006	Chem.2005, 48, 1873], we described the discovery of a class of benzimidazole chk2 kinase inhibitors, exemplified by compound 1, which had radio-protective effects in human T-cells subjected to ionizing radiation.	benzimidazole	63-76	checkpoint kinase 2	Homo sapiens	77-81
16442290-3	2006	Here, a series of non-benzimidazole analogs intended to define the scope of the SAR about this new series of inhibitor, and allow for refinement of the binding model of these compounds to the chk2 kinase is described.	benzimidazole	22-35	sarcosine dehydrogenase	Homo sapiens	80-83
16442290-3	2006	Here, a series of non-benzimidazole analogs intended to define the scope of the SAR about this new series of inhibitor, and allow for refinement of the binding model of these compounds to the chk2 kinase is described.	benzimidazole	22-35	checkpoint kinase 2	Homo sapiens	192-196
16539403-3	2006	Benzimidazole derivative 8b was active in an in vivo target (TGF-beta RI) inhibition assay.	benzimidazole	0-13	transforming growth factor beta receptor 1	Homo sapiens	61-72
16307491-3	2005	Triclabendazole, a benzimidazole derivative, has been routinely used since 1983 in veterinary medicine to control infections with Fasciola spp.	benzimidazole	19-32	histocompatibility minor 13	Homo sapiens	139-142
16125538-1	2005	This is the first report of the effects of a nonthiazolidinedione activator of peroxisome proliferator-activated receptor (PPAR) gamma, that is, FK-614 (a benzimidazole derivative), on glucose metabolism in vivo.	benzimidazole	155-168	peroxisome proliferator activated receptor gamma	Canis lupus familiaris	79-134
15664860-0	2005	Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists.	benzimidazole	0-13	gonadotropin releasing hormone 1	Homo sapiens	46-83
15703302-0	2005	Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2).	benzimidazole	26-39	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	49-81
15703302-0	2005	Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2).	benzimidazole	26-39	BCR pseudogene 1	Homo sapiens	83-87
15703302-0	2005	Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2).	benzimidazole	26-39	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	88-93
15664860-0	2005	Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists.	benzimidazole	0-13	gonadotropin releasing hormone 1	Homo sapiens	85-89
15099830-1	2004	Equilibrium binding dynamics is studied for a panel of benzimidazole-containing compounds at the remodeled interface between human growth hormone (hGH) and the extracellular domain of its receptor (hGHbp), engineered by mutating to glycine hot spot residues T175 from the hormone and W104 from the receptor.	benzimidazole	55-68	growth hormone 1	Homo sapiens	131-145
15664861-0	2005	Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists.	benzimidazole	0-13	gonadotropin releasing hormone 1	Homo sapiens	46-83
15664861-0	2005	Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists.	benzimidazole	0-13	gonadotropin releasing hormone 1	Homo sapiens	85-89
15261287-0	2004	Structure-activity relationships of potent and selective factor Xa inhibitors: benzimidazole derivatives with the side chain oriented to the prime site of factor Xa.	benzimidazole	79-92	coagulation factor X	Homo sapiens	57-66
15261287-0	2004	Structure-activity relationships of potent and selective factor Xa inhibitors: benzimidazole derivatives with the side chain oriented to the prime site of factor Xa.	benzimidazole	79-92	coagulation factor X	Homo sapiens	155-164
15261287-1	2004	A series of benzimidazole derivatives with the side chain on the nitrogen atom oriented to the prime site of factor Xa (FXa) were designed and synthesized.	benzimidazole	12-25	coagulation factor X	Homo sapiens	109-118
15261287-1	2004	A series of benzimidazole derivatives with the side chain on the nitrogen atom oriented to the prime site of factor Xa (FXa) were designed and synthesized.	benzimidazole	12-25	coagulation factor X	Homo sapiens	120-123
15278126-0	2004	A study on the mimics of Cu-Zn superoxide dismutase with high activity and stability: two copper(II) complexes of 1,4,7-triazacyclononane with benzimidazole groups.	benzimidazole	143-156	superoxide dismutase 1	Homo sapiens	25-51
15635167-2	2005	We previously reported that a benzoimidazole derivative, M50367, acted directly on naive Th cells to inhibit their differentiation into Th2 cells.	benzimidazole	30-44	heart and neural crest derivatives expressed 2	Mus musculus	136-139
15351401-1	2004	Part 5: design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.	benzimidazole	36-49	tankyrase	Homo sapiens	0-6
15351401-1	2004	Part 5: design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.	benzimidazole	36-49	5-hydroxytryptamine receptor 1A	Homo sapiens	93-99
15351401-2	2004	A series of new mixed benzimidazole-arylpiperazine derivatives were designed by incorporating in general structure III the pharmacophoric elements of 5-HT(1A) and 5-HT(3) receptors.	benzimidazole	22-35	5-hydroxytryptamine receptor 1A	Homo sapiens	150-157
15099830-1	2004	Equilibrium binding dynamics is studied for a panel of benzimidazole-containing compounds at the remodeled interface between human growth hormone (hGH) and the extracellular domain of its receptor (hGHbp), engineered by mutating to glycine hot spot residues T175 from the hormone and W104 from the receptor.	benzimidazole	55-68	growth hormone receptor	Homo sapiens	198-203
15099830-3	2004	The results of simulated tempering ligand dynamics at the protein-protein interface reveals a diversity of ligand binding modes that is consistent with the structural orientation of the benzimidazole ring which closely mimics the position of the mutated W104 hot spot residue in the wild-type hGH-hGHbp complex.	benzimidazole	186-199	growth hormone receptor	Homo sapiens	297-302
14987951-5	2004	The mechanism of benzimidazole-mediated induction of CYP1A1 was investigated by comparison with 3-MC, a prototypical AhR ligand.	benzimidazole	17-30	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	53-59
14691014-0	2004	A benzimidazole fungicide, benomyl, and its metabolite, carbendazim, induce aromatase activity in a human ovarian granulose-like tumor cell line (KGN).	benzimidazole	2-15	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	76-85
14987951-5	2004	The mechanism of benzimidazole-mediated induction of CYP1A1 was investigated by comparison with 3-MC, a prototypical AhR ligand.	benzimidazole	17-30	aryl hydrocarbon receptor	Rattus norvegicus	117-120
12951088-0	2003	Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.	benzimidazole	28-41	5-hydroxytryptamine receptor 1A	Homo sapiens	85-91
14691134-2	2003	The budding uninhibited by benzimidazole (Bub) 1, mitotic arrest-deficient (Mad) 1, and Mad2 proteins promote this checkpoint through sustained inhibition of the anaphase-promoting complex/cyclosome.	benzimidazole	27-40	MAX dimerization protein 1 L homeolog	Xenopus laevis	50-82
14517972-2	2003	Multiple docking simulations are conducted with the remodeled hGH-hGHbp complex for a panel of potent benzimidazole-containing inhibitors that can restore the binding affinity of the wild-type complex, and for a set of known nonactive small molecules that contain different heterocyclic motifs.	benzimidazole	102-115	growth hormone receptor	Homo sapiens	66-71
14517972-5	2003	Despite numerous pockets on the protein surface of the mutant hGH-hGHbp complex, the binding-site cavity presents the energetically favorable hot spot for the benzimidazole-containing inhibitors, whereas for a set of nonactive molecules, the lowest energy ligand conformations do not necessarily bind in the engineered cavity.	benzimidazole	159-172	growth hormone receptor	Homo sapiens	66-71
12519059-1	2003	Novel tricyclic benzimidazole carboxamide poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized.	benzimidazole	16-29	poly(ADP-ribose) polymerase 1	Homo sapiens	42-71
14525526-4	2003	Moreover, the spindle checkpoint component budding uninhibited by benzimidazole 1 (BUB1) localizes to kinetochores and is phosphorylated until anaphase of both meiotic M phases.	benzimidazole	66-79	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	83-87
12772307-4	2003	An analogous eta(6)-arene,eta(1)-carbene complex with a benzimidazole frame 6 was isolated from an in situ reaction between [RuCl(2)(p-cymene)](2), the corresponding benzimidazolium salt and cesium carbonate.	benzimidazole	56-69	endothelin receptor type A	Homo sapiens	13-16
12772307-4	2003	An analogous eta(6)-arene,eta(1)-carbene complex with a benzimidazole frame 6 was isolated from an in situ reaction between [RuCl(2)(p-cymene)](2), the corresponding benzimidazolium salt and cesium carbonate.	benzimidazole	56-69	endothelin receptor type A	Homo sapiens	26-29
12679136-5	2003	CYP3A4 was the only CYP3A isoform that was induced by all of the four benzimidazole derivatives, while CYP3A5, CYP3A7, and CYP3A43 were unaffected or even slightly downregulated by these drugs.	benzimidazole	70-83	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
12679136-5	2003	CYP3A4 was the only CYP3A isoform that was induced by all of the four benzimidazole derivatives, while CYP3A5, CYP3A7, and CYP3A43 were unaffected or even slightly downregulated by these drugs.	benzimidazole	70-83	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-5
15317289-4	2003	Reported herein is the pharmacology of potent, low molecular weight thrombin receptor antagonists from pyrroloquinazoline, benzimidazole, and himbacine series.	benzimidazole	123-136	coagulation factor II, thrombin	Homo sapiens	68-76
12591101-0	2003	New benzimidazole derivatives: selective and orally active 5-HT3 receptor antagonists.	benzimidazole	4-17	5-hydroxytryptamine receptor 3A	Rattus norvegicus	59-73
12591101-5	2003	These benzimidazole derivatives have proved to be 5-HT(3) receptor antagonists.	benzimidazole	6-19	5-hydroxytryptamine receptor 3A	Rattus norvegicus	50-66
12519059-1	2003	Novel tricyclic benzimidazole carboxamide poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized.	benzimidazole	16-29	poly(ADP-ribose) polymerase 1	Homo sapiens	73-79
12113886-5	2002	All three analogs (purine, benzimidazole, and 7-azaindole) exhibited affinity for PepT1 in binding studies, but only the purine analog (as the L-valine ester) showed PepT1-associated transcellular transport across Caco-2 cell monolayers.	benzimidazole	27-40	solute carrier family 15 member 1	Homo sapiens	82-87
12113886-6	2002	The benzimidazole and 7-azaindole analogs (as their L-valine esters) were rapidly metabolized by esterase when applied to the apical surface of Caco-2 cells, which probably explains their low penetration as the intact prodrugs via PepT1.	benzimidazole	4-17	solute carrier family 15 member 1	Homo sapiens	231-236
11825309-1	2001	Lansoprazole (Prevacid, TAP Pharmaceuticals, Inc.) is a substituted benzimidazole that inhibits gastric acid secretion.	benzimidazole	68-81	nuclear RNA export factor 1	Homo sapiens	24-27
11965377-1	2002	A novel potent and selective aminophenol scaffold for fXa inhibitors was developed from a previously reported benzimidazole-based naphthylamidine template.	benzimidazole	110-123	coagulation factor X	Homo sapiens	54-57
11965378-0	2002	Benzimidazole-based fXa inhibitors with improved thrombin and trypsin selectivity.	benzimidazole	0-13	coagulation factor X	Homo sapiens	20-23
11965378-0	2002	Benzimidazole-based fXa inhibitors with improved thrombin and trypsin selectivity.	benzimidazole	0-13	coagulation factor II, thrombin	Homo sapiens	49-57
11965378-1	2002	Optimization of the benzimidazole-based fXa inhibitors for selectivity versus thrombin and trypsin was achieved by substitution on the benzimidazole ring and replacement of the naphthylamidine group.	benzimidazole	20-33	coagulation factor X	Homo sapiens	40-43
11965378-1	2002	Optimization of the benzimidazole-based fXa inhibitors for selectivity versus thrombin and trypsin was achieved by substitution on the benzimidazole ring and replacement of the naphthylamidine group.	benzimidazole	20-33	coagulation factor II, thrombin	Homo sapiens	78-86
11965378-1	2002	Optimization of the benzimidazole-based fXa inhibitors for selectivity versus thrombin and trypsin was achieved by substitution on the benzimidazole ring and replacement of the naphthylamidine group.	benzimidazole	135-148	coagulation factor X	Homo sapiens	40-43
11965378-1	2002	Optimization of the benzimidazole-based fXa inhibitors for selectivity versus thrombin and trypsin was achieved by substitution on the benzimidazole ring and replacement of the naphthylamidine group.	benzimidazole	135-148	coagulation factor II, thrombin	Homo sapiens	78-86
11965378-2	2002	Substitution of a nitro group at the 4-position on the benzimidazole improves both potency against fXa and selectivity versus thrombin.	benzimidazole	55-68	coagulation factor X	Homo sapiens	99-102
11965378-2	2002	Substitution of a nitro group at the 4-position on the benzimidazole improves both potency against fXa and selectivity versus thrombin.	benzimidazole	55-68	coagulation factor II, thrombin	Homo sapiens	126-134
11597414-1	2001	Several benzimidazole derivatives have been identified as potent thrombin receptor (PAR-1) antagonists as represented by compound 1h, which showed an IC(50) of 33 nM.	benzimidazole	8-21	coagulation factor II thrombin receptor	Homo sapiens	84-89
12052197-3	2002	This article will review the development of the most important classes of 5-HT(4R) antagonists with an emphasis on benzimidazole derivatives, their structure-affinity relationships, ligand-receptor interactions and pharmacological applications.	benzimidazole	115-128	5-hydroxytryptamine receptor 4	Homo sapiens	74-81
11868391-4	2002	On the other hand, benzimidazole compounds can induce CYP1A1 without binding to the Ah receptor as a ligand (ligand-independent pathway).	benzimidazole	19-32	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	54-60
11300866-3	2001	Appropriate substitution on the benzimidazole ring, especially with small alkyl groups, led to dramatic increases in potency, both in a cellular assay of apoB secretion and especially in animal models of cholesterol lowering.	benzimidazole	32-45	apolipoprotein B-100	Macaca fascicularis	154-158
11055353-0	2000	1,2-Disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: a novel series of thrombin inhibitors.	benzimidazole	26-35	coagulation factor II, thrombin	Homo sapiens	109-117
11169164-3	2001	Only compound 7a, with the presence of both the pyridyl moiety bound at the ethylenic bridge in C-2 of benzimidazole and the nitro-group in the benzene ring, displays a selective antiproliferative effect against certain leukaemia cells and a good antiviral activity especially towards the Coxsackie B5 virus.	benzimidazole	103-116	complement C2	Homo sapiens	96-99
11063605-2	2000	Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase.	benzimidazole	39-52	poly(ADP-ribose) polymerase 1	Gallus gallus	89-116
11055353-0	2000	1,2-Disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: a novel series of thrombin inhibitors.	benzimidazole	40-53	coagulation factor II, thrombin	Homo sapiens	109-117
11055353-1	2000	A novel series of 1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing an amine moiety was identified as thrombin inhibitors.	benzimidazole	44-53	coagulation factor II, thrombin	Homo sapiens	129-137
11055353-1	2000	A novel series of 1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing an amine moiety was identified as thrombin inhibitors.	benzimidazole	58-71	coagulation factor II, thrombin	Homo sapiens	129-137
10103034-0	1999	Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells.	benzimidazole	90-103	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	67-86
10853669-0	2000	Design, synthesis, and in vitro biological activity of benzimidazole based factor Xa inhibitors.	benzimidazole	55-68	coagulation factor X	Homo sapiens	75-84
10853669-1	2000	Inhibitors based on the benzimidazole scaffold showed subnanomolar potency against Factor Xa with 500-1000-fold selectivity against thrombin and 50-100-fold selectivity against trypsin.	benzimidazole	24-37	coagulation factor X	Homo sapiens	83-92
10853669-1	2000	Inhibitors based on the benzimidazole scaffold showed subnanomolar potency against Factor Xa with 500-1000-fold selectivity against thrombin and 50-100-fold selectivity against trypsin.	benzimidazole	24-37	coagulation factor II, thrombin	Homo sapiens	132-140
10853669-2	2000	The 2-substituent on the benzimidazole ring had a strong impact on the FXa inhibitory activity.	benzimidazole	25-38	coagulation factor X	Homo sapiens	71-74
11079373-3	2000	We observed a marked increase in ALP activity in the serum of rats given a benzimidazole derivative by gavage, and detected it as slow-migrating ALPs (SM-ALPs), which were mALP-like but resistant to PIPLC and n-butanol treatment on disc PAGE.	benzimidazole	75-88	alopecia, recessive	Mus musculus	33-36
10936227-1	2000	Thiabendazole (TBZ), an anthelmintic and fungicide benzimidazole, was recently demonstrated to be extensively metabolized by cytochrome P450 (CYP) 1A2 in man and rabbit, yielding 5-hydroxythiabendazole (5OH-TBZ), the major metabolite furtherly conjugated, and two minor unidentified metabolites (M1 and M2).	benzimidazole	51-64	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	125-150
10660561-3	2000	In stably expressing HEK293 cells, the benzimidazole-reactive cysteines, Cys-321 (transmembrane helix (TM) 3), Cys-813 and Cys-822 (TM5/6), and Cys-892 (TM7/8) were mutated to the amino acids found in the SCH28080-resistant Na,K-ATPase and kinetic parameters of H,K-ATPase activity analyzed.	benzimidazole	39-52	tropomyosin 3	Homo sapiens	132-135
10605056-0	1999	Synthesis of benzimidazole derivatives as antiallergic agents with 5-lipoxygenase inhibiting action.	benzimidazole	13-26	arachidonate 5-lipoxygenase	Rattus norvegicus	67-81
10605056-1	1999	Syntheses were conducted of novel benzimidazole derivatives that suppress histamine release from mast cells, inhibit 5-lipoxygenase, and possess antioxidative action.	benzimidazole	34-47	arachidonate 5-lipoxygenase	Rattus norvegicus	117-131
10572257-2	1999	We also show results extending the knowledge of the range of compounds to which FLR1 gene confers resistance to the antimitotic systemic benzimidazole fungicide benomyl and the antitumor agent methotrexate, reinforcing the concept that the FLR1 gene is a multidrug resistance (MDR) determinant.	benzimidazole	137-150	Flr1p	Saccharomyces cerevisiae S288C	80-84
10572257-2	1999	We also show results extending the knowledge of the range of compounds to which FLR1 gene confers resistance to the antimitotic systemic benzimidazole fungicide benomyl and the antitumor agent methotrexate, reinforcing the concept that the FLR1 gene is a multidrug resistance (MDR) determinant.	benzimidazole	137-150	Flr1p	Saccharomyces cerevisiae S288C	240-244
10445394-1	1999	Benzimidazole compounds, such as omeprazole and thiabendazole, are a different type of CYP1A1-inducer from Ah receptor-ligands, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 3-methylcholanthrene.	benzimidazole	0-13	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-93
10103034-1	1999	The effect of several structurally different benzimidazole compounds on CYP1A1 expression at the transcriptional, mRNA and protein levels was investigated in the rat hepatoma H4IIE cell line.	benzimidazole	45-58	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	72-78
9702206-4	1998	The antiproliferative activity and the maximum potency of antiviral activity correlate with the presence of both the 2-pyridyl moiety bound at the ethylenic bridge in C-2 of benzimidazole and the nitro group in the benzene ring.	benzimidazole	174-187	complement C2	Homo sapiens	167-170
9990464-0	1999	Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.	benzimidazole	0-9	dopamine receptor D4	Homo sapiens	49-69
9873696-0	1998	Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.	benzimidazole	0-13	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	102-116
9873696-1	1998	In a 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists containing a benzimidazole as a novel arginine mimetic, we examined the effects of benzimidazole modifications and amide substitutions on both activity and pharmacokinetics.	benzimidazole	117-130	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	84-90
9784250-1	1998	Benzimidazole compounds, such as omeprazole and thiabendazole, are a different type of CYP1A1 inducer from Ah receptor-ligands, such as TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) and 3-methylcholanthrene.	benzimidazole	0-13	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-93
9784250-1	1998	Benzimidazole compounds, such as omeprazole and thiabendazole, are a different type of CYP1A1 inducer from Ah receptor-ligands, such as TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) and 3-methylcholanthrene.	benzimidazole	0-13	aryl hydrocarbon receptor	Homo sapiens	107-118
9873613-1	1998	A new family of PDE4 inhibitors based on a benzimidazole framework is described.	benzimidazole	43-56	phosphodiesterase 4A	Homo sapiens	16-20
9258368-8	1997	The inhibitory profile exhibited by this new class of NMT ligands is a function of the pKa of the imidazole substituent as illustrated by the benzimidazole analog 35 which is about 10-fold less potent than 31.	benzimidazole	142-155	N-myristoyltransferase 1	Homo sapiens	54-57
9699220-10	1998	This points to the importance of electronic properties of substituents in position 2 of benzimidazole ring for the D2/5-HT1A affinity ratio of this type of ligands.	benzimidazole	88-101	5-hydroxytryptamine receptor 1A	Bos taurus	118-124
9041675-2	1997	Induction of endogenous cytochrome P4501A1 (CYP1A1) by benzimidazole derivatives has been investigated in the human hepatoma cell line HepG2.	benzimidazole	55-68	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	24-42
9211916-9	1997	CobT phosphoribosylated alternative base substrates including benzimidazole, 4,5-dimethyl-1,2-phenylenediamine, imidazole, histidine, adenine, and guanine in vitro.	benzimidazole	62-75	nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	0-4
9041675-0	1997	Effects of benzimidazole derivatives on cytochrome P450 1A1 expression in a human hepatoma cell line.	benzimidazole	11-24	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	40-59
9041675-2	1997	Induction of endogenous cytochrome P4501A1 (CYP1A1) by benzimidazole derivatives has been investigated in the human hepatoma cell line HepG2.	benzimidazole	55-68	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	44-50
8900397-0	1996	Differences in inducibility of CYP1A1-mRNA by benzimidazole compounds between human and mouse cells: evidences of a human-specific signal transduction pathway for CYP1A1 induction.	benzimidazole	46-59	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-37
8967990-1	1996	We identified a novel azaindole derivative, L-750,667, that has high affinity (Ki = 0.51 nM) and >2000-fold selectivity for D4 dopamine receptors compared with its activity at D2 and D3 dopamine receptors.	benzimidazole	22-31	Rho GDP dissociation inhibitor beta	Homo sapiens	127-129
8900397-0	1996	Differences in inducibility of CYP1A1-mRNA by benzimidazole compounds between human and mouse cells: evidences of a human-specific signal transduction pathway for CYP1A1 induction.	benzimidazole	46-59	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	163-169
8855719-3	1996	A number of benzimidazole derivatives were synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity in order to study structure-activity relationships.	benzimidazole	12-25	cholecystokinin A receptor	Homo sapiens	89-104
8258826-2	1993	Systemic variation of several substituents at the benzimidazole ring positions 4-7 led to the finding that substitution in position 6 with acylamino groups results in highly active AII antagonists.	benzimidazole	50-63	angiotensinogen	Rattus norvegicus	181-184
7733914-1	1995	Benzimidazole derivatives are potent inducers of CYP1A1 in rabbit and human hepatocytes, but apparently do not bind the AH receptor.	benzimidazole	0-13	cytochrome P450 1A1	Oryctolagus cuniculus	49-55
7877171-6	1995	All H. contortus tub-1 constructs, which encoded Phe at position 200, conferred susceptibility to thiabendazole in BZ-resistant C. elegans ben-1 mutants.	benzimidazole	115-117	Tubby protein homolog 1	Caenorhabditis elegans	17-22
7877171-6	1995	All H. contortus tub-1 constructs, which encoded Phe at position 200, conferred susceptibility to thiabendazole in BZ-resistant C. elegans ben-1 mutants.	benzimidazole	115-117	Tubulin beta chain	Caenorhabditis elegans	139-144
7710270-8	1994	Thus, while introduction of a benzimidazole group into the PR inhibitors was a successful structural modification with regard to antiviral activity in cell culture, it completely abolished oral bioavailability.	benzimidazole	30-43	endogenous retrovirus group K member 25	Homo sapiens	59-61
8647108-0	1996	Induction of CYP1A1 gene by benzimidazole derivatives during Caco-2 cell differentiation.	benzimidazole	28-41	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
8647108-10	1996	The induction of CYP1A1 transcription by benzimidazole derivatives in Caco-2 cells occurred with no direct binding of benzimidazole derivatives to the aryl-hydrocarbon receptor, as in human hepatocytes.	benzimidazole	41-54	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	17-23
8647108-13	1996	These results question about the mechanism of ligand-independent activation of the aryl-hydrocarbon receptor and intracellular signaling, initiated by benzimidazole derivatives.	benzimidazole	151-164	aryl hydrocarbon receptor	Homo sapiens	83-108
20650191-9	1996	Different induction rates obtained with several benzimidazole drugs suggest that the sulfur atom within the molecule is critical for CYP1A1 induction.	benzimidazole	48-61	cytochrome P450 1A1	Oryctolagus cuniculus	133-139
20650191-10	1996	The widely used benzimidazole anthelmintics OFZ and FBZ may exert an inducing effect through an original pathway that does not require a specific binding step to the Ah receptor.	benzimidazole	16-29	aryl hydrocarbon receptor	Oryctolagus cuniculus	166-177
7877171-3	1995	Functional analysis of a conserved beta-tubulin isotype (tub-1) mutation near GTP-binding domain II, which is linked to BZ resistance, was carried out in C. elegans by heterologous expression of: (1) parasite BZ-sensitive alleles; (2) BZ-resistant alleles; and (3) in vitro mutagenised beta-tubulin gene constructs.	benzimidazole	120-122	Tubby protein homolog 1	Caenorhabditis elegans	57-62
7877171-3	1995	Functional analysis of a conserved beta-tubulin isotype (tub-1) mutation near GTP-binding domain II, which is linked to BZ resistance, was carried out in C. elegans by heterologous expression of: (1) parasite BZ-sensitive alleles; (2) BZ-resistant alleles; and (3) in vitro mutagenised beta-tubulin gene constructs.	benzimidazole	209-211	Tubby protein homolog 1	Caenorhabditis elegans	57-62
7877171-3	1995	Functional analysis of a conserved beta-tubulin isotype (tub-1) mutation near GTP-binding domain II, which is linked to BZ resistance, was carried out in C. elegans by heterologous expression of: (1) parasite BZ-sensitive alleles; (2) BZ-resistant alleles; and (3) in vitro mutagenised beta-tubulin gene constructs.	benzimidazole	209-211	Tubby protein homolog 1	Caenorhabditis elegans	57-62
8258826-4	1993	In contrast, analogous substitution of the benzimidazole moiety with basic heterocycles resulted in potent AII antagonists which were also well absorbed after oral application.	benzimidazole	43-56	angiotensinogen	Rattus norvegicus	107-110
8401764-4	1993	The preliminary SAR studies indicate the importance of chlorine atom at position 3 in diazine nucleus and of alkyl substituents in benzimidazole moiety for positive inotropic effects.	benzimidazole	131-144	sarcosine dehydrogenase	Homo sapiens	16-19
8488169-1	1993	BIBS 39 and BIBS 222 are novel, nonpeptide angiotensin II receptor antagonists with a benzimidazole structure.	benzimidazole	86-99	angiotensinogen	Rattus norvegicus	43-57
8487256-0	1993	Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists.	benzimidazole	56-69	thromboxane A2 receptor	Homo sapiens	117-140
1388592-1	1992	The influence of bioisosteric replacement of catechol moiety of L-Dopa and alpha-Methyldopa with benzimidazole and benzotriazole ring has been examined on dopamine beta-hydroxylase and tyrosinase, in order to evidentiate an inhibitory activity on the synthesis of catecholamines and a possible antihypertensive action.	benzimidazole	97-110	tyrosinase	Homo sapiens	185-195
1280125-1	1992	Omeprazole is a benzimidazole derivative which induces both P450 1A1 and 1A2 in human liver in vitro and in vivo.	benzimidazole	16-29	solute carrier family 45 member 2	Homo sapiens	65-68
1886288-1	1991	Antisecretory effects of a substituted benzimidazole, (+/-)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl]-1H-benzimidazole (AG-1749) were compared with those of a histamine H2-receptor antagonist, famotidine.	benzimidazole	39-52	histamine receptor H2	Canis lupus familiaris	185-206
1748033-3	1991	Omeprazole contains a benzimidazole moiety and thus has the potential to interact with the cytochrome P-450 enzyme group.	benzimidazole	22-35	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	91-107
2016714-0	1991	Receptor-based design of novel dihydrofolate reductase inhibitors: benzimidazole and indole derivatives.	benzimidazole	67-80	Dihydrofolate reductase	Escherichia coli	31-54
1548677-6	1992	The benzimidazole antagonists displaced AII in binding studies in vitro with IC50 values in the range 10(-5)-10(-7) M and antagonized the hypertensive effects of AII in vivo (rats) following intravenous administration with ED50 values in the range of 5-20 mg/kg.	benzimidazole	4-17	angiotensinogen	Rattus norvegicus	40-43
1548677-6	1992	The benzimidazole antagonists displaced AII in binding studies in vitro with IC50 values in the range 10(-5)-10(-7) M and antagonized the hypertensive effects of AII in vivo (rats) following intravenous administration with ED50 values in the range of 5-20 mg/kg.	benzimidazole	4-17	angiotensinogen	Rattus norvegicus	162-165
1738300-6	1992	Incubation of hookworms with some benzimidazole anthelmintics viz., mebendazole or albendazole significantly reduced the capacity of the worms to secrete cholinesterase and increase in enzyme activity within the parasite.	benzimidazole	34-47	butyrylcholinesterase	Homo sapiens	154-168
1738300-8	1992	These observations indicate role of microtubules in the secretion of cholinesterase by hookworms and as a target for the action of benzimidazole anthelmintics.	benzimidazole	131-144	butyrylcholinesterase	Homo sapiens	69-83
34931332-0	2022	Design, synthesis, biological activity, molecular docking, and molecular dynamics of novel benzimidazole derivatives as potential AChE/MAO-B dual inhibitors.	benzimidazole	91-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	130-134
33764593-0	2021	Theoretical Insights into Molecular Mechanism and Energy Criteria of PARP-2 Enzyme Inhibition by Benzimidazole Analogues.	benzimidazole	97-110	poly(ADP-ribose) polymerase 2	Homo sapiens	69-75
34971430-2	2021	BRP-201, a novel benzimidazole-based FLAP antagonist, inhibits leukotriene biosynthesis in isolated leukocytes.	benzimidazole	17-30	arachidonate 5-lipoxygenase activating protein	Homo sapiens	37-41
33766769-0	2021	Exploring naltrexamine derivatives featuring azaindole moiety via nitrogen-walk approach to investigate their in vitro pharmacological profiles at the mu opioid receptor.	benzimidazole	45-54	opioid receptor mu 1	Homo sapiens	151-169
34931332-0	2022	Design, synthesis, biological activity, molecular docking, and molecular dynamics of novel benzimidazole derivatives as potential AChE/MAO-B dual inhibitors.	benzimidazole	91-104	monoamine oxidase B	Homo sapiens	135-140
34931332-1	2022	To develop new acetylcholinesterase (AChE)-monoamine oxidase-B (MAO-B) dual inhibitors against Alzheimer"s disease, the benzimidazole ring, which has a propargyl side chain with previously proven selective MAO-B inhibitory activity, was used as the main structure.	benzimidazole	120-133	acetylcholinesterase (Cartwright blood group)	Homo sapiens	15-35
34931332-1	2022	To develop new acetylcholinesterase (AChE)-monoamine oxidase-B (MAO-B) dual inhibitors against Alzheimer"s disease, the benzimidazole ring, which has a propargyl side chain with previously proven selective MAO-B inhibitory activity, was used as the main structure.	benzimidazole	120-133	acetylcholinesterase (Cartwright blood group)	Homo sapiens	37-41
34931332-1	2022	To develop new acetylcholinesterase (AChE)-monoamine oxidase-B (MAO-B) dual inhibitors against Alzheimer"s disease, the benzimidazole ring, which has a propargyl side chain with previously proven selective MAO-B inhibitory activity, was used as the main structure.	benzimidazole	120-133	monoamine oxidase B	Homo sapiens	43-62
34931332-1	2022	To develop new acetylcholinesterase (AChE)-monoamine oxidase-B (MAO-B) dual inhibitors against Alzheimer"s disease, the benzimidazole ring, which has a propargyl side chain with previously proven selective MAO-B inhibitory activity, was used as the main structure.	benzimidazole	120-133	monoamine oxidase B	Homo sapiens	64-69
34931332-1	2022	To develop new acetylcholinesterase (AChE)-monoamine oxidase-B (MAO-B) dual inhibitors against Alzheimer"s disease, the benzimidazole ring, which has a propargyl side chain with previously proven selective MAO-B inhibitory activity, was used as the main structure.	benzimidazole	120-133	monoamine oxidase B	Homo sapiens	206-211
34561907-3	2021	In this study, a 1D-3D mixed-dimensional perovskite material is explored by adding an organic salt with a bulk benzimidazole cation (Bn+ ).	benzimidazole	111-124	zinc finger protein of the cerebellum 3	Mus musculus	133-136
34225075-3	2021	The present study introduces Beta-cyclodextrin (beta-CD) as a novel/effective organic nano-container for Benzimidazole (BM) encapsulation to obtain reliable active protection property via a controlled-release property.	benzimidazole	105-118	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	48-55
34852738-4	2022	METHODS: About 25 articles were collected that discussed various benzimidazole derivatives and categorized them under various subheadings based on the targets such as BACE 1, JNK, MAO, choline esterase enzyme, oxidative stress, mitochondrial dysfunction in which they act.	benzimidazole	65-78	beta-secretase 1	Homo sapiens	167-173
34852738-4	2022	METHODS: About 25 articles were collected that discussed various benzimidazole derivatives and categorized them under various subheadings based on the targets such as BACE 1, JNK, MAO, choline esterase enzyme, oxidative stress, mitochondrial dysfunction in which they act.	benzimidazole	65-78	mitogen-activated protein kinase 8	Homo sapiens	175-178
34225075-3	2021	The present study introduces Beta-cyclodextrin (beta-CD) as a novel/effective organic nano-container for Benzimidazole (BM) encapsulation to obtain reliable active protection property via a controlled-release property.	benzimidazole	120-122	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	48-55
34225075-10	2021	The dispersion-corrected Density Functional Theory (DFT)-D explorations ascertained the inclusion capacity of benzimidazole inside the beta-CD.	benzimidazole	110-123	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	135-142
34225180-0	2021	Benzimidazole-galactosides bind selectively to the Galectin-8 N-Terminal domain: Structure-based design and optimisation.	benzimidazole	0-13	galectin 8	Homo sapiens	51-61
34737234-8	2021	Using a proprietary translational technology platform, a drug library screen identified a substituted benzimidazole as a Bach1 inhibitor that was validated as a nonelectrophile.	benzimidazole	102-115	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	121-126
34225180-6	2021	Thus, the benzimidazole-derivatised galactosides represent promising compounds for studies of the pathological implications of galectin-8, as well as a starting point for the development of anti-tumour and anti-inflammatory therapeutics targeting galectin-8.	benzimidazole	10-23	galectin 8	Homo sapiens	127-137
34517794-10	2022	CONCLUSION: Benzothiazole, benzoxazole, benzimidazole, and sulfhydryl derivatives stand out as TIM inhibitors.	benzimidazole	40-53	triosephosphate isomerase 1	Homo sapiens	95-98
34795863-2	2021	The design, synthesis, and protein affinity evaluation of a set of C-3 substituted benzimidazole and quinoline d-galactal derivatives identified a d-galactal-benzimidazole hybrid as a selective ligand for the galectin-8 N-terminal domain (galectin-8N), with a K d of 48 muM and 15-fold selectivity over galectin-3 and even better selectivity over the other mammalian galectins.	benzimidazole	83-96	galectin 8	Homo sapiens	209-219
34795863-2	2021	The design, synthesis, and protein affinity evaluation of a set of C-3 substituted benzimidazole and quinoline d-galactal derivatives identified a d-galactal-benzimidazole hybrid as a selective ligand for the galectin-8 N-terminal domain (galectin-8N), with a K d of 48 muM and 15-fold selectivity over galectin-3 and even better selectivity over the other mammalian galectins.	benzimidazole	158-171	galectin 8	Homo sapiens	209-219
34795863-2	2021	The design, synthesis, and protein affinity evaluation of a set of C-3 substituted benzimidazole and quinoline d-galactal derivatives identified a d-galactal-benzimidazole hybrid as a selective ligand for the galectin-8 N-terminal domain (galectin-8N), with a K d of 48 muM and 15-fold selectivity over galectin-3 and even better selectivity over the other mammalian galectins.	benzimidazole	158-171	galectin 3	Homo sapiens	303-313
34651438-0	2021	Insights into the structure and drug design of benzimidazole derivatives targeting the epidermal growth factor receptor (EGFR).	benzimidazole	47-60	epidermal growth factor receptor	Homo sapiens	87-119
34651438-0	2021	Insights into the structure and drug design of benzimidazole derivatives targeting the epidermal growth factor receptor (EGFR).	benzimidazole	47-60	epidermal growth factor receptor	Homo sapiens	121-125
34651438-5	2021	Despite numerous publications on the design, synthesis and biological assays of benzimidazole derivatives, their inhibitory activities against epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK), have not been specifically analysed.	benzimidazole	80-93	epidermal growth factor receptor	Homo sapiens	143-175
34651438-5	2021	Despite numerous publications on the design, synthesis and biological assays of benzimidazole derivatives, their inhibitory activities against epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK), have not been specifically analysed.	benzimidazole	80-93	epidermal growth factor receptor	Homo sapiens	177-181
34651438-6	2021	This review covers recent research reports on the anticancer activity of benzimidazole derivatives focusing on EGFR expression cell lines, based on their structure-activity relationship study.	benzimidazole	73-86	epidermal growth factor receptor	Homo sapiens	111-115
34651438-7	2021	We believe it would aid researchers to envision the challenges and explore benzimidazole"s potentials as tyrosine kinase inhibitors.	benzimidazole	75-88	TXK tyrosine kinase	Homo sapiens	105-120
34681742-4	2021	Following a previous lead scaffold, benzimidazole moiety was modified with various aryl groups and hydroxylation, and the resulting compounds exhibited JNK3 inhibitory activity with improved potency and selectivity.	benzimidazole	36-49	mitogen activated protein kinase 10	Rattus norvegicus	152-156
34516105-1	2021	Substitution of apical halide ligands in ({Re6Sei8}Xa6)3- (X = Cl, Br) by benzimidazole (bimzH) accompanied by a self-assembly process leads to the formation of microporous Re6-based hydrogen-bonded organic frameworks (Re6-HOFs) constructed on N-H   X hydrogen bonds and pi-pi-stacking interactions between bimzH ligands.	benzimidazole	74-87	chromosome 12 open reading frame 73	Homo sapiens	67-69
34579637-0	2022	Inhibition of iNOS by Benzimidazole Derivatives: Synthesis, Docking, and Biological Evaluations.	benzimidazole	22-35	nitric oxide synthase 2	Rattus norvegicus	14-18
34579637-3	2022	OBJECTIVE: The present work was aimed to design, synthesize and evaluate benzimidazole-coumarin coupled molecules as anti-iNOS agents through in silico and pharmacological studies.	benzimidazole	73-86	nitric oxide synthase 2	Rattus norvegicus	122-126
34579637-14	2022	CONCLUSION: The newly synthesized benzimidazole-coumarin hybrids may serve as potential leads for the development of novel anti-iNOS agents.	benzimidazole	34-47	nitric oxide synthase 2	Rattus norvegicus	128-132
34482215-4	2021	The study aimed to generate a homology model for the beta-tubulin of S. mansoni using the crystal structure of O visaries (Sheep) beta-tubulin (PDB ID: 3N2G D) as a template, then different beta-tubulin models were generated and two previously reported benzimidazole derivatives (NBTP-F and NBTP-OH) were docked to the generated models, the binding results indicated that both S. mansoni, S. haematobium were susceptible to the two NBTP derivatives.	benzimidazole	253-266	beta-tubulin	Ovis aries	53-65
34482215-7	2021	Moreover, additional seven new benzimidazole derivatives were synthesized and tested by molecular docking on the generated model binding site of S. mansoni beta-tubulin and were found to have good interaction inside the pocket.	benzimidazole	31-44	beta-tubulin	Ovis aries	156-168
34423556-8	2021	Finally, all atom molecular dynamics simulations determined the most energetically favorable binding mode for PQ912, in the active site of sQC, which is similar to that of LSB-09, a recently reported sQC inhibitor containing benzimidazole-6-carboxamide moiety.	benzimidazole	225-238	glutaminyl-peptide cyclotransferase	Homo sapiens	200-203
34722993-1	2021	A novel triazole-bridged coumarin-benzimidazole-conjugated fluorescence sensor (4) has been developed for selective detection of Cd2+ over other competitive metal ions.	benzimidazole	34-47	CD2 molecule	Homo sapiens	129-132
34722993-4	2021	The involvement of benzimidazole and triazole moieties in Cd2+ binding was confirmed by different spectroscopic techniques such as UV-vis, Fourier transform infrared, nuclear magnetic resonance, and ESI mass.	benzimidazole	19-32	CD2 molecule	Homo sapiens	58-61
34403955-0	2021	Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity.	benzimidazole	13-26	aldehyde dehydrogenase 1 family member A1	Homo sapiens	63-89
34403955-0	2021	Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity.	benzimidazole	13-26	aldehyde dehydrogenase 1 family member A1	Homo sapiens	91-98
34128259-0	2021	Design, synthesis, and biological evaluation of novel benzimidazole derivatives as sphingosine kinase 1 inhibitor.	benzimidazole	54-67	sphingosine kinase 1	Homo sapiens	83-103
34128259-4	2021	Our design strategy is twofold: It aimed first to study the effect of replacing the 5-position of the benzimidazole ring with a polar carboxylic acid group on the SphK1-inhibitory activity and cytotoxicity.	benzimidazole	102-115	sphingosine kinase 1	Homo sapiens	163-168
34128259-7	2021	The binding affinity of the benzimidazole derivatives toward SphK1 was measured by fluorescence binding and molecular docking.	benzimidazole	28-41	sphingosine kinase 1	Homo sapiens	61-66
34337627-1	2021	Introduction of the propyl-sulfonic acid group at N1 of the coordinated 2-(2-pyridyl)benzimidazole ligand (L) in (RhCl(eta5-C5Me5)L)(CF3SO3) gives rise to a water-soluble complex, which can bind to the model protein lysozyme via non-covalent interactions.	benzimidazole	84-98	lysozyme	Homo sapiens	216-224
34586727-0	2021	Dual blocking of PI3K and mTOR signaling by DHW-221, a novel benzimidazole derivative, exerts antitumor activity in human non-small cell lung cancer.	benzimidazole	61-74	mechanistic target of rapamycin kinase	Homo sapiens	26-30
34153810-4	2021	The target benzimidazole 3f containing hydroxyl motif at para-position of phenyl revealed an important activity inhibitor against alpha- amylase (IC50 = 12.09 +- 0.38 microM) and alpha-glucosidase (IC50 = 11.02 +- 0.04 microM) comparable to the reference drug acarbose.	benzimidazole	11-24	sucrase-isomaltase	Homo sapiens	179-196
34121397-0	2021	Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORgamma Inverse Agonist.	benzimidazole	34-47	RAR-related orphan receptor gamma	Mus musculus	110-118
34373541-1	2021	We have recently described Pz-1, a benzimidazole-based type-2 RET and VEGFR2 inhibitor.	benzimidazole	35-48	ret proto-oncogene	Homo sapiens	62-65
34373541-1	2021	We have recently described Pz-1, a benzimidazole-based type-2 RET and VEGFR2 inhibitor.	benzimidazole	35-48	kinase insert domain receptor	Homo sapiens	70-76
34225394-2	2022	In this paper, we look for the in vitro cytotoxic capability of novel benzimidazole-based N-heterocyclic carbene (NHC) precursor (1) and its Ag(I)-NHC complex (2).	benzimidazole	70-83	high mobility group nucleosomal binding domain 4	Homo sapiens	114-117
34225394-2	2022	In this paper, we look for the in vitro cytotoxic capability of novel benzimidazole-based N-heterocyclic carbene (NHC) precursor (1) and its Ag(I)-NHC complex (2).	benzimidazole	70-83	high mobility group nucleosomal binding domain 4	Homo sapiens	147-150
34121397-2	2021	Herein, we report our effort on the discovery, optimization, and evaluation of benzothiazole and benzimidazole derivatives as novel inverse agonists of RORgamma.	benzimidazole	97-110	RAR-related orphan receptor gamma	Mus musculus	152-160
34567143-7	2021	Compound B18, a benzimidazole derivative, has an excellent binding affinity towards CRF-1 protein compared to reference molecules; hence, this compound could be a potential drug candidate for stress-dependent disorders.	benzimidazole	16-29	corticotropin releasing hormone receptor 1	Homo sapiens	84-89
34101459-1	2021	The spectroscopic characterization of the benzimidazole (BIM) homodimer was carried out in a molecular beam in the ground state as well as in the cationic state using the R2PI and RIDIR methods.	benzimidazole	42-55	superoxide dismutase 1	Homo sapiens	62-71
34101459-1	2021	The spectroscopic characterization of the benzimidazole (BIM) homodimer was carried out in a molecular beam in the ground state as well as in the cationic state using the R2PI and RIDIR methods.	benzimidazole	57-60	superoxide dismutase 1	Homo sapiens	62-71
35569250-0	2022	Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti-proliferative activity in multiple cancer cells.	benzimidazole	19-32	E1A binding protein p300	Homo sapiens	55-59
35513222-4	2022	However, there have been few reports of direct AMPK activator with high potency for beta2-AMPK isoform, which is thought to be important for glucose homeostasis, and their chemical structure is limited to benzimidazole core.	benzimidazole	205-218	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	47-51
35513222-4	2022	However, there have been few reports of direct AMPK activator with high potency for beta2-AMPK isoform, which is thought to be important for glucose homeostasis, and their chemical structure is limited to benzimidazole core.	benzimidazole	205-218	ATPase H+ transporting V0 subunit a2	Homo sapiens	84-89
35636123-7	2022	The benzimidazole-quinazolinone derivatives 14f,g revealed potent RAF kinases inhibitory activities on BRAF (wt), BRAF (V600E) and CRAF showing IC50 values 0.002-0.1 microM, whereas, the benzimidazole-quinazolinone derivatives 14i and 14k showed moderate VEGFR-2 inhibitory activity (IC50 = 20.60 and 6.14 microM, respectively).	benzimidazole	4-17	zinc fingers and homeoboxes 2	Homo sapiens	66-69
35513222-4	2022	However, there have been few reports of direct AMPK activator with high potency for beta2-AMPK isoform, which is thought to be important for glucose homeostasis, and their chemical structure is limited to benzimidazole core.	benzimidazole	205-218	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	90-94
35489524-3	2022	Although most benzimidazole derivatives are commonly less toxic, their effects on SIRTs and cytochrome P450 (CYP) regulations have not been explored alongside toxicity assessments.	benzimidazole	14-27	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	92-107
35489524-3	2022	Although most benzimidazole derivatives are commonly less toxic, their effects on SIRTs and cytochrome P450 (CYP) regulations have not been explored alongside toxicity assessments.	benzimidazole	14-27	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	109-112
35595366-4	2022	In this study, we developed a fluorescent probe for the discriminative sensing of Cl- and Br- using a naphthalimide-benzimidazole conjugate-based Ag+ complex (L1-Ag+ complex) by exploiting the strong interaction between Ag+ and halide ions with selectivity control by pH variation.	benzimidazole	116-129	chromosome 12 open reading frame 73	Homo sapiens	82-92
35595366-4	2022	In this study, we developed a fluorescent probe for the discriminative sensing of Cl- and Br- using a naphthalimide-benzimidazole conjugate-based Ag+ complex (L1-Ag+ complex) by exploiting the strong interaction between Ag+ and halide ions with selectivity control by pH variation.	benzimidazole	116-129	S100 calcium binding protein A8	Homo sapiens	159-164
35576659-1	2022	Ligands comprising a benzimidazole rather than the imidazole ring that is common in AT2R ligands e.g. in the AT2R agonist C21, can provide both high affinity and receptor selectivity.	benzimidazole	21-34	TBL1X/Y related 1	Homo sapiens	122-125
35636123-7	2022	The benzimidazole-quinazolinone derivatives 14f,g revealed potent RAF kinases inhibitory activities on BRAF (wt), BRAF (V600E) and CRAF showing IC50 values 0.002-0.1 microM, whereas, the benzimidazole-quinazolinone derivatives 14i and 14k showed moderate VEGFR-2 inhibitory activity (IC50 = 20.60 and 6.14 microM, respectively).	benzimidazole	4-17	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	103-107
35636123-7	2022	The benzimidazole-quinazolinone derivatives 14f,g revealed potent RAF kinases inhibitory activities on BRAF (wt), BRAF (V600E) and CRAF showing IC50 values 0.002-0.1 microM, whereas, the benzimidazole-quinazolinone derivatives 14i and 14k showed moderate VEGFR-2 inhibitory activity (IC50 = 20.60 and 6.14 microM, respectively).	benzimidazole	4-17	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	114-118
35636123-7	2022	The benzimidazole-quinazolinone derivatives 14f,g revealed potent RAF kinases inhibitory activities on BRAF (wt), BRAF (V600E) and CRAF showing IC50 values 0.002-0.1 microM, whereas, the benzimidazole-quinazolinone derivatives 14i and 14k showed moderate VEGFR-2 inhibitory activity (IC50 = 20.60 and 6.14 microM, respectively).	benzimidazole	4-17	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	131-135
35636123-7	2022	The benzimidazole-quinazolinone derivatives 14f,g revealed potent RAF kinases inhibitory activities on BRAF (wt), BRAF (V600E) and CRAF showing IC50 values 0.002-0.1 microM, whereas, the benzimidazole-quinazolinone derivatives 14i and 14k showed moderate VEGFR-2 inhibitory activity (IC50 = 20.60 and 6.14 microM, respectively).	benzimidazole	187-200	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	103-107
35636123-7	2022	The benzimidazole-quinazolinone derivatives 14f,g revealed potent RAF kinases inhibitory activities on BRAF (wt), BRAF (V600E) and CRAF showing IC50 values 0.002-0.1 microM, whereas, the benzimidazole-quinazolinone derivatives 14i and 14k showed moderate VEGFR-2 inhibitory activity (IC50 = 20.60 and 6.14 microM, respectively).	benzimidazole	187-200	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	114-118
35636123-7	2022	The benzimidazole-quinazolinone derivatives 14f,g revealed potent RAF kinases inhibitory activities on BRAF (wt), BRAF (V600E) and CRAF showing IC50 values 0.002-0.1 microM, whereas, the benzimidazole-quinazolinone derivatives 14i and 14k showed moderate VEGFR-2 inhibitory activity (IC50 = 20.60 and 6.14 microM, respectively).	benzimidazole	187-200	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	131-135
35636124-2	2022	Herein, to develop specific pharmacologic inhibitors of HIPK2, we designed and synthesized a series of compounds containing benzimidazole and pyrimidine scaffolds via fragment-based drug design strategy.	benzimidazole	124-137	homeodomain interacting protein kinase 2	Rattus norvegicus	56-61
35557491-0	2022	Further exploration of the benzimidazole scaffold as TRPC5 inhibitors: identification of 1-alkyl-2-(pyrrolidin-1-yl)-1H-benzo(d)imidazoles as potent and selective inhibitors.	benzimidazole	27-40	transient receptor potential cation channel subfamily C member 5	Homo sapiens	53-58
35438328-0	2022	Computational study reveals substituted benzimidazole derivatives" binding selectivity to PI3Kdelta and PI3Kgamma.	benzimidazole	40-53	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	90-99
35624746-0	2022	Study on the Neuroprotective, Radical-Scavenging and MAO-B Inhibiting Properties of New Benzimidazole Arylhydrazones as Potential Multi-Target Drugs for the Treatment of Parkinson"s Disease.	benzimidazole	88-101	monoamine oxidase B	Homo sapiens	53-58
35438328-0	2022	Computational study reveals substituted benzimidazole derivatives" binding selectivity to PI3Kdelta and PI3Kgamma.	benzimidazole	40-53	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	104-113
35438328-4	2022	Preliminary studies have obtained PI3K inhibitors bearing a benzimidazole structural motif with a certain selectivity for PI3Kdelta and PI3Kgamma subtypes.	benzimidazole	60-73	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	122-131
35438328-4	2022	Preliminary studies have obtained PI3K inhibitors bearing a benzimidazole structural motif with a certain selectivity for PI3Kdelta and PI3Kgamma subtypes.	benzimidazole	60-73	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	136-145
35033885-0	2022	Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia.	benzimidazole	15-28	fms related receptor tyrosine kinase 3	Homo sapiens	40-44
35184951-1	2022	Benzimidazole 1 (BUB1) and budding uninhibited by benzimidazole 1-related 1 (BUBR1) are multidomain paralogs with key roles in chromosome alignment during mitosis and the spindle assembly checkpoint (SAC), an evolutionarily conserved signaling pathway that monitors errors in chromosome segregation during cell division in eukaryotes.	benzimidazole	0-13	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	17-21
35184951-1	2022	Benzimidazole 1 (BUB1) and budding uninhibited by benzimidazole 1-related 1 (BUBR1) are multidomain paralogs with key roles in chromosome alignment during mitosis and the spindle assembly checkpoint (SAC), an evolutionarily conserved signaling pathway that monitors errors in chromosome segregation during cell division in eukaryotes.	benzimidazole	50-63	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	77-82
35319364-11	2022	We hope that enlightened by the previous researches, more researches of AD site should be occurred and more effective benzimidazole PARP-1 inhibitors could be designed, synthesized, and applied to clinics.	benzimidazole	118-131	poly(ADP-ribose) polymerase 1	Homo sapiens	132-138
35152061-0	2022	Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase.	benzimidazole	13-26	prostaglandin E synthase	Mus musculus	73-80
35152061-0	2022	Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase.	benzimidazole	13-26	leukotriene C4 synthase	Homo sapiens	132-155
35319364-0	2022	Recent Progress of the research on the benzimidazole PARP-1 inhibitors.	benzimidazole	39-52	poly(ADP-ribose) polymerase 1	Homo sapiens	53-59
35319364-5	2022	However, the commercial available benzimidazole PARP-1 inhibitors have some shortcomings such as serious toxicity in combination with chemotherapy drugs, in vivo cardiovascular side effects such as anemia.	benzimidazole	34-47	poly(ADP-ribose) polymerase 1	Homo sapiens	48-54
35319364-6	2022	Therefore it"s crucial for scientists to explore more structure-activity relationships of the benzimidazole PARP-1 inhibitors and access safer and more effective PARP inhibitors.	benzimidazole	94-107	poly(ADP-ribose) polymerase 1	Homo sapiens	108-114
35319364-7	2022	As the binding region of PARP-1 and the substrates is usually characterized as NI site and AD site, the modification of benzimidazoles mainly occurs on the benzimidazole skeleton (NI site), and the side chain of benzimidazole on 2-C position (AD site).	benzimidazole	156-169	poly(ADP-ribose) polymerase 1	Homo sapiens	25-31
35319364-7	2022	As the binding region of PARP-1 and the substrates is usually characterized as NI site and AD site, the modification of benzimidazoles mainly occurs on the benzimidazole skeleton (NI site), and the side chain of benzimidazole on 2-C position (AD site).	benzimidazole	212-225	poly(ADP-ribose) polymerase 1	Homo sapiens	25-31
35156516-3	2022	The expression level of miR-664b-3p and Budding uninhibited by benzimidazole 3 (Bub3) in colon cancer cell lines and tissues were detected and analyzed using quantitative real-time PCR and bioinformatics method.	benzimidazole	63-76	BUB3 mitotic checkpoint protein	Homo sapiens	80-84
35148084-0	2022	Identification of the Benzoimidazole Compound as a Selective FLT3 Inhibitor by Cell-Based High-Throughput Screening of a Diversity Library.	benzimidazole	22-36	fms related receptor tyrosine kinase 3	Homo sapiens	61-65
35148084-7	2022	Our findings establish the specific activity of the benzoimidazole compound against FLT3/ITD leukemia and warrant further investigation in this subset of leukemia patients with poor prognosis.	benzimidazole	52-66	fms related receptor tyrosine kinase 3	Homo sapiens	84-88
35193612-1	2022	Novel temperature and pH dual-sensitive amphiphilic micelles were fabricated exploiting the host-guest interaction between benzimidazole-terminated PHEMA-g-(PCL-BM) and beta-CD-star-PMAA-b-PNIPAM.	benzimidazole	123-136	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	169-176
35033885-0	2022	Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia.	benzimidazole	15-28	neurotrophic receptor tyrosine kinase 1	Homo sapiens	45-49
35033885-4	2022	Guided by ligand-based design and structure simplification of the FLT3 inhibitor, quizartinib, we developed a benzimidazole-based small molecule, 4ACP, that exhibited nanomolar activity against wild-type FLT3, FLT3-Internal tandem duplications (FLT3-ITD), and FLT3-D835Y (FLT3-TKD) mutation (IC50 = 43.8, 97.2, and 92.5 nM respectively).	benzimidazole	110-123	fms related receptor tyrosine kinase 3	Homo sapiens	66-70
35033885-4	2022	Guided by ligand-based design and structure simplification of the FLT3 inhibitor, quizartinib, we developed a benzimidazole-based small molecule, 4ACP, that exhibited nanomolar activity against wild-type FLT3, FLT3-Internal tandem duplications (FLT3-ITD), and FLT3-D835Y (FLT3-TKD) mutation (IC50 = 43.8, 97.2, and 92.5 nM respectively).	benzimidazole	110-123	fms related receptor tyrosine kinase 3	Homo sapiens	204-208
35033885-4	2022	Guided by ligand-based design and structure simplification of the FLT3 inhibitor, quizartinib, we developed a benzimidazole-based small molecule, 4ACP, that exhibited nanomolar activity against wild-type FLT3, FLT3-Internal tandem duplications (FLT3-ITD), and FLT3-D835Y (FLT3-TKD) mutation (IC50 = 43.8, 97.2, and 92.5 nM respectively).	benzimidazole	110-123	fms related receptor tyrosine kinase 3	Homo sapiens	210-214
35033885-4	2022	Guided by ligand-based design and structure simplification of the FLT3 inhibitor, quizartinib, we developed a benzimidazole-based small molecule, 4ACP, that exhibited nanomolar activity against wild-type FLT3, FLT3-Internal tandem duplications (FLT3-ITD), and FLT3-D835Y (FLT3-TKD) mutation (IC50 = 43.8, 97.2, and 92.5 nM respectively).	benzimidazole	110-123	fms related receptor tyrosine kinase 3	Homo sapiens	245-249
35033885-4	2022	Guided by ligand-based design and structure simplification of the FLT3 inhibitor, quizartinib, we developed a benzimidazole-based small molecule, 4ACP, that exhibited nanomolar activity against wild-type FLT3, FLT3-Internal tandem duplications (FLT3-ITD), and FLT3-D835Y (FLT3-TKD) mutation (IC50 = 43.8, 97.2, and 92.5 nM respectively).	benzimidazole	110-123	fms related receptor tyrosine kinase 3	Homo sapiens	260-264
35033885-4	2022	Guided by ligand-based design and structure simplification of the FLT3 inhibitor, quizartinib, we developed a benzimidazole-based small molecule, 4ACP, that exhibited nanomolar activity against wild-type FLT3, FLT3-Internal tandem duplications (FLT3-ITD), and FLT3-D835Y (FLT3-TKD) mutation (IC50 = 43.8, 97.2, and 92.5 nM respectively).	benzimidazole	110-123	fms related receptor tyrosine kinase 3	Homo sapiens	272-276
2592410-7	1989	Since the deletion strains appear to be fully resistant to the drugs, the ben-1 product appears to be the only benzimidazole-sensitive beta-tubulin in C. elegans.	benzimidazole	111-124	Tubulin beta chain	Caenorhabditis elegans	74-79