PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23179605-3	2013	However, the GBD-1 prepropeptide is shorter by 18 amino acids due to the presence of the stop codon UAA at position 209-211 in GBD-1 mRNA.	prepropeptide	19-32	LOW QUALITY PROTEIN: beta-defensin 1	Capra hircus	13-18
23179605-3	2013	However, the GBD-1 prepropeptide is shorter by 18 amino acids due to the presence of the stop codon UAA at position 209-211 in GBD-1 mRNA.	prepropeptide	19-32	LOW QUALITY PROTEIN: beta-defensin 1	Capra hircus	127-132
14669991-2	2003	The amino acid sequence deduced from a full-length cDNA revealed that transmembrane serine protease-1 (TMSP-1) is a member of the clan SA/family S1 of serine proteases, comprising a 30 amino acid prepropeptide, a mature form sequence of 274 amino acids starting with the Ile-Val-Gly-Gly-Gln motif, and a common catalytic triad of serine proteases.	prepropeptide	196-209	protease, serine, 30	Rattus norvegicus	70-101
22934245-1	2012	The proopiomelanocortin (Pomc) gene encodes a prepropeptide with essential functions in the response to stress and energy balance, which is expressed in the pituitary and hypothalamus of vertebrate animals.	prepropeptide	46-59	proopiomelanocortin	Homo sapiens	4-23
22934245-1	2012	The proopiomelanocortin (Pomc) gene encodes a prepropeptide with essential functions in the response to stress and energy balance, which is expressed in the pituitary and hypothalamus of vertebrate animals.	prepropeptide	46-59	proopiomelanocortin	Homo sapiens	25-29
19394425-1	2009	In humans, the Apelin gene is located on chromosome Xq25-26.1 and it encodes a 77-aminoacid prepropeptide.	prepropeptide	92-105	apelin	Homo sapiens	15-21
18996160-5	2009	Suncus motilin is predicted to exist as a 117-residue prepropeptide that undergoes proteolytic cleavage to form a 22-amino-acid mature peptide.	prepropeptide	54-67	motilin	Homo sapiens	7-14
18162287-2	2008	Like other members of the transforming growth factor-beta (TGFbeta) superfamily, GDF9 is synthesized as a prepropeptide which needs processing by furin-like proteases to result in an active mature protein.	prepropeptide	106-119	growth differentiation factor 9	Homo sapiens	81-85
17412804-2	2007	VP is synthesized as part of a prepropeptide in magnocellular neurons of the hypothalamic supraoptic nucleus (SON) and paraventricular nucleus.	prepropeptide	31-44	arginine vasopressin	Rattus norvegicus	0-2
21084715-4	2011	Using specific antibodies developed for zebrafish Igf3, both the Igf3 prepropeptide and the mature peptide forms of Igf3 were found to be predominantly expressed in the zebrafish ovary.	prepropeptide	70-83	insulin-like growth factor 3	Danio rerio	50-54
21084715-4	2011	Using specific antibodies developed for zebrafish Igf3, both the Igf3 prepropeptide and the mature peptide forms of Igf3 were found to be predominantly expressed in the zebrafish ovary.	prepropeptide	70-83	insulin-like growth factor 3	Danio rerio	65-69
21084715-4	2011	Using specific antibodies developed for zebrafish Igf3, both the Igf3 prepropeptide and the mature peptide forms of Igf3 were found to be predominantly expressed in the zebrafish ovary.	prepropeptide	70-83	insulin-like growth factor 3	Danio rerio	65-69
21829727-5	2011	This human In1-ghrelin variant would encode a new prepropeptide that conserves the first 12aa of native-ghrelin (including the Ser3-potential octanoylation site) but has a different C-terminal tail.	prepropeptide	50-63	appetite-regulating hormone	Capra hircus	15-22
21829727-5	2011	This human In1-ghrelin variant would encode a new prepropeptide that conserves the first 12aa of native-ghrelin (including the Ser3-potential octanoylation site) but has a different C-terminal tail.	prepropeptide	50-63	appetite-regulating hormone	Capra hircus	104-111
20955171-3	2011	Hepcidin is encoded as an 84 amino acid prepropeptide that is successively cleaved to yield prohepcidin and the mature 25 amino acid hepcidin.	prepropeptide	40-53	hepcidin antimicrobial peptide	Homo sapiens	0-8
20955171-3	2011	Hepcidin is encoded as an 84 amino acid prepropeptide that is successively cleaved to yield prohepcidin and the mature 25 amino acid hepcidin.	prepropeptide	40-53	hepcidin antimicrobial peptide	Homo sapiens	95-103
20861221-1	2010	TGF-beta family ligands are translated as prepropeptide precursors and are processed into mature C-terminal dimers that signal by assembling a serine/threonine kinase receptor complex containing type I and II components.	prepropeptide	42-55	transforming growth factor beta 1	Homo sapiens	0-8
17905609-1	2008	Hepcidin is encoded as an 84 amino acid prepropeptide containing a typical N-terminal 24 amino acid endoplasmic reticulum targeting signal sequence, and a 35 amino acid proregion (pro) with a consensus furin cleavage site immediately followed by the C-terminal 25 amino acid bioactive iron-regulatory hormone (mature peptide).	prepropeptide	40-53	hepcidin antimicrobial peptide	Homo sapiens	0-8
16249312-1	2006	The magnocellular neurons (MCNs) of the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus are the principal site of biosynthesis of prepropeptide precursor of the antidiuretic hormone vasopressin (VP).	prepropeptide	161-174	arginine vasopressin	Rattus norvegicus	213-224
16249312-1	2006	The magnocellular neurons (MCNs) of the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus are the principal site of biosynthesis of prepropeptide precursor of the antidiuretic hormone vasopressin (VP).	prepropeptide	161-174	arginine vasopressin	Rattus norvegicus	226-228
15043943-5	2004	Zebrafish hepcidin genes consist of two introns and three exons that encode a prepropeptide (91 amino acids).	prepropeptide	78-91	hepcidin antimicrobial peptide	Homo sapiens	10-18
14669991-2	2003	The amino acid sequence deduced from a full-length cDNA revealed that transmembrane serine protease-1 (TMSP-1) is a member of the clan SA/family S1 of serine proteases, comprising a 30 amino acid prepropeptide, a mature form sequence of 274 amino acids starting with the Ile-Val-Gly-Gly-Gln motif, and a common catalytic triad of serine proteases.	prepropeptide	196-209	protease, serine, 30	Rattus norvegicus	103-109
11159841-4	2001	This suggested that nuclear PTHrP proteins contain part of the prepropeptide and likely arise from alternate initiation of translation at downstream non-AUG codons within the signal sequence.	prepropeptide	63-76	parathyroid hormone like hormone	Homo sapiens	28-33
14675762-4	2003	By means of reverse pharmacology screening using a peptide library generated from human hemofiltrate, we have isolated and identified TIG2 as the natural ligand of ChemR23 and report the specific molecular form of the bioactive, circulating TIG2, representing the amino-acid residues 21 to 154 of the 163 amino acid-containing prepropeptide.	prepropeptide	327-340	retinoic acid receptor responder 2	Homo sapiens	134-138
14675762-4	2003	By means of reverse pharmacology screening using a peptide library generated from human hemofiltrate, we have isolated and identified TIG2 as the natural ligand of ChemR23 and report the specific molecular form of the bioactive, circulating TIG2, representing the amino-acid residues 21 to 154 of the 163 amino acid-containing prepropeptide.	prepropeptide	327-340	retinoic acid receptor responder 2	Homo sapiens	241-245
11504119-2	2001	Endothelin-1, the most potent vasoconstrictor peptide of the endothelin family, is synthesized initially as a large prepropeptide that requires multiple steps of post-translational processing for activation.	prepropeptide	116-129	endothelin-1	Oryctolagus cuniculus	0-12
12466190-1	2002	Members of the TGF-beta superfamily, which includes TGF-betas, growth differentiation factors, bone morphogenetic proteins, activins, inhibins, and glial cell line-derived neurotrophic factor, are synthesized as prepropeptide precursors and then processed and secreted as homodimers or heterodimers.	prepropeptide	212-225	glial cell derived neurotrophic factor	Homo sapiens	148-191
11254635-5	2001	The precursor of gallinacin-3 contained a long C-terminal extension not present in the prepropeptide.	prepropeptide	87-100	avian beta-defensin 3	Gallus gallus	17-29
10051766-2	1999	Here we show that in the snail Lymnaea the SCP gene exists in one interrupted copy that produces a single species of transcript which encodes a prepropeptide containing two structurally related SCPs SGYLAFPRMamide (SCP(A)) and pQNYLAFPRMamide (SCP(B)).	prepropeptide	144-157	urocortin 3	Homo sapiens	43-46
10719625-4	1999	One mutant, delta C18 osmotin, had a nonsense mutation near the C-terminus that deleted the carboxyl terminal prepropeptide (CTPP) of 18 amino acids.	prepropeptide	110-123	osmotin	Nicotiana tabacum	22-29
9268634-3	1997	The 362-bp cDNA encoded a prepropeptide that corresponded precisely to the recently identified human beta-defensin HBD-1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization.	prepropeptide	26-39	defensin beta 1	Homo sapiens	115-120
9188469-4	1997	Key structural features of the sPLA2 include: (i) a long prepropeptide ending with an arginine doublet, (ii) 16 cysteines located at positions that are characteristic of both group I and group II sPLA2s, (iii) a C-terminal extension typical of group II sPLA2s, (iv) and the absence of elapid and pancreatic loops that are characteristic of group I sPLA2s.	prepropeptide	57-70	phospholipase A2 group X	Homo sapiens	31-36
10499420-3	1999	The encoded, putative prepropeptide can be processed into an amidated NPF with 36 residues that is related to invertebrate NPF"s and the neuropeptide Y family of vertebrates.	prepropeptide	22-35	neuropeptide F	Drosophila melanogaster	70-73
10499420-3	1999	The encoded, putative prepropeptide can be processed into an amidated NPF with 36 residues that is related to invertebrate NPF"s and the neuropeptide Y family of vertebrates.	prepropeptide	22-35	neuropeptide F	Drosophila melanogaster	123-126
8895381-0	1996	Neurohypophyseal and fluid homeostasis in transgenic rats expressing a tagged rat vasopressin prepropeptide in hypothalamic neurons.	prepropeptide	94-107	arginine vasopressin	Rattus norvegicus	82-93
2849988-7	1988	RSKG-3 is highly homologous to RSKG-7 in terms of its sequence and structure; it encodes a 28,730-dalton prepropeptide consisting of a signal peptide of 18 aa, a profragment of 6 aa, and an active peptide of 235 aa.	prepropeptide	105-118	kallikrein 1-related peptidase C12	Rattus norvegicus	0-6
1542665-4	1992	Here we show by cDNA analysis that the prepropeptide for the human granulins is a 593-residue glycoprotein, containing seven tandem repeats of the 12-cysteine granulin domain.	prepropeptide	39-52	granulin precursor	Homo sapiens	67-76
1542665-4	1992	Here we show by cDNA analysis that the prepropeptide for the human granulins is a 593-residue glycoprotein, containing seven tandem repeats of the 12-cysteine granulin domain.	prepropeptide	39-52	granulin precursor	Rattus norvegicus	67-75
7506260-2	1994	One of these transcripts has a structure identical to that of the hypothalamic RNA that encodes the vasopressin prepropeptide, but is present at such low levels that it can only be detected by the polymerase chain reaction.	prepropeptide	112-125	arginine vasopressin	Rattus norvegicus	100-111
2071595-1	1991	Several cDNA clones, encoding prepropeptide of human collagen alpha 1(V) chain, have been isolated.	prepropeptide	30-43	collagen type V alpha 1 chain	Homo sapiens	62-72
2071595-2	1991	The prepropeptide (1838 amino acids length) of the alpha 1(V) chain was composed of a putative signal peptide, a large NH2-terminal noncollagenous region, a main collagenous region, and a COOH-terminal noncollagenous region.	prepropeptide	4-17	collagen type V alpha 1 chain	Homo sapiens	51-61
1696253-1	1990	Sucrose gradient and Northern analyses were used to study the translational status of endogenous multiple mRNAs encoding the prepropeptide for human insulin-like growth factor II.	prepropeptide	125-138	insulin like growth factor 2	Homo sapiens	149-178
35144664-8	2022	We then showed that cocaine and amphetamine regulated transcript prepropeptide (CARTPT) and breast cancer-associated transcript 54 (BRCAT54) mRNA-previously shown by microarray analysis to be highly expressed in DCIS-were detectable in these samples.	prepropeptide	65-78	CART prepropeptide	Homo sapiens	80-86
2849988-7	1988	RSKG-3 is highly homologous to RSKG-7 in terms of its sequence and structure; it encodes a 28,730-dalton prepropeptide consisting of a signal peptide of 18 aa, a profragment of 6 aa, and an active peptide of 235 aa.	prepropeptide	105-118	kallikrein 1	Rattus norvegicus	31-37
3001722-3	1986	[International nomenclature starting at the end of the signal peptide of the recently sequenced prepropeptide is used; thus, ANF-(101-126) corresponds to the earlier designation ANF-(8-33), ANF-(103-123) to rat atriopeptin I, and ANF-(103-125) to rat atriopeptin II.]	prepropeptide	96-109	natriuretic peptide A	Rattus norvegicus	125-128
3184206-2	1988	Rat NGF shows very high homology with other known NGFs in both the prepropeptide and the 3" untranslated regions.	prepropeptide	67-80	nerve growth factor	Rattus norvegicus	4-7
3606613-5	1987	These results suggest that the nascent chain of cathepsin H has a transient N-terminal prepropeptide.	prepropeptide	87-100	cathepsin H	Homo sapiens	48-59
6135195-0	1983	Chick pro alpha 2 (I) collagen gene: exon location and coding potential for the prepropeptide.	prepropeptide	80-93	collagen type I alpha 2 chain	Gallus gallus	10-30
6089171-4	1984	The predicted 403-amino acid preprorenin consists of mature renin and a 66-residue amino-terminal prepropeptide.	prepropeptide	98-111	renin	Homo sapiens	35-40
6405383-6	1983	Our findings indicate that apo A-I is synthesized as a prepropeptide, which undergoes intracellular and extracellular proteolysis to attain the major plasma apo A-I4 isoprotein form.	prepropeptide	55-68	apolipoprotein A1	Homo sapiens	27-34
32852148-2	2020	LOX-v2 lacks the N-terminal prepropeptide region of LOX but contains the C-terminal domains required for amine oxidase activity.	prepropeptide	28-41	lysyl oxidase	Homo sapiens	0-3
25846300-1	2015	Arginine vasopressin (AVP) is a neurohypophysial hormone synthesized as a part of a prepropeptide precursor containing the signal peptide, AVP hormone, AVP-associated neurophysin II and copeptin in the hypothalamic neurosecretory neurons.	prepropeptide	84-97	arginine vasopressin	Rattus norvegicus	9-20
23796362-3	2013	In the present study full-length ghrelin cDNA was isolated from bubaline abomasum, which encodes the entire prepropeptide of 116 amino acids.	prepropeptide	108-121	ghrelin and obestatin prepropeptide	Bos taurus	33-40
23829781-4	2013	Our strategy utilized a prepropeptide from the C. albicans secreted aspartic proteinase, Sap2p.	prepropeptide	24-37	ribonuclease A family member 7	Homo sapiens	89-94