PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15337764-4	2004	Active phenylurea-based compounds dissociated effector protease caspase-3 but not initiator protease caspase-9 from XIAP in vitro and restored caspase-3 but not caspase-9 enzymatic activity.	N-phenylurea	7-17	caspase 3	Homo sapiens	64-73
15771462-3	2005	SAR studies showed that the 3-acetylphenyl urea of 32 could be replaced with heterocyclic ureas or heterocyclic-substituted phenyl ureas and still maintain the potency (inhibition of eotaxin-induced chemotaxis) of this class of compounds in the low-picomolar range (IC(50) = 10-60 pM), representing some of the most potent CCR3 antagonists reported to date.	N-phenylurea	124-136	chemokine (C-C motif) ligand 11	Mus musculus	183-190
16380255-0	2006	Phenyl ureas of creatinine as mGluR5 antagonists.	N-phenylurea	0-12	glutamate receptor, ionotropic, kainate 1	Mus musculus	30-36
15337764-4	2004	Active phenylurea-based compounds dissociated effector protease caspase-3 but not initiator protease caspase-9 from XIAP in vitro and restored caspase-3 but not caspase-9 enzymatic activity.	N-phenylurea	7-17	X-linked inhibitor of apoptosis	Homo sapiens	116-120
15337764-4	2004	Active phenylurea-based compounds dissociated effector protease caspase-3 but not initiator protease caspase-9 from XIAP in vitro and restored caspase-3 but not caspase-9 enzymatic activity.	N-phenylurea	7-17	caspase 3	Homo sapiens	143-152
15337764-4	2004	Active phenylurea-based compounds dissociated effector protease caspase-3 but not initiator protease caspase-9 from XIAP in vitro and restored caspase-3 but not caspase-9 enzymatic activity.	N-phenylurea	7-17	caspase 9	Homo sapiens	161-170
15337764-6	2004	Apoptosis induced by active phenylurea-based compounds was blocked by chemical inhibitors of caspases, with inhibitors of downstream effector caspases displaying more effective suppression than inhibitors of upstream initiator caspases.	N-phenylurea	28-38	caspase 9	Homo sapiens	93-101
15337764-7	2004	Phenylurea-based XIAP antagonists induced apoptosis (defined by annexin V staining) prior to mitochondrial membrane depolarization, in contrast to cytotoxic anticancer drugs.	N-phenylurea	0-10	X-linked inhibitor of apoptosis	Homo sapiens	17-21
10435283-0	1998	Application of an androgen receptor assay for the characterisation of the androgenic or antiandrogenic activity of various phenylurea herbicides and their derivatives.	N-phenylurea	123-133	androgen receptor	Bos taurus	18-35
9990096-4	1999	In vitro enzyme assays showed that the gene product of one heterologously expressed P450 cDNA (CYP71A10) specifically catalyzed the metabolism of phenylurea herbicides, converting four herbicides of this class (fluometuron, linuron, chlortoluron, and diuron) into more polar compounds.	N-phenylurea	146-156	cytochrome P450 71A10	Glycine max	95-103
10467457-4	1999	The increase in liver glutathione (GSH) contents observed after CCl4 treatment was further increased by PHU treatment.	N-phenylurea	104-107	C-C motif chemokine ligand 4	Rattus norvegicus	64-68
10467457-6	1999	PHU administration further inhibited the decrease in liver catalase activity after CCl4 treatment.	N-phenylurea	0-3	C-C motif chemokine ligand 4	Rattus norvegicus	83-87
10467457-7	1999	These results indicate that PHU administration can prevent liver injury induced by CCl4 in rats by inhibiting enhanced lipid peroxidation and by improving disrupted active oxygen metabolism in the injured liver.	N-phenylurea	28-31	C-C motif chemokine ligand 4	Rattus norvegicus	83-87
9862022-3	1998	PHU prevented the increase in hepatic glutathione (GSH) and lipid peroxidation induced by CCl4.	N-phenylurea	0-3	C-C motif chemokine ligand 4	Rattus norvegicus	90-94
10467457-2	1999	Significant prevention of liver injury by PHU was found after CCl4 treatment, judging by the changes of serum biochemical parameters, and hepatic protein and triglyceride contents.	N-phenylurea	42-45	C-C motif chemokine ligand 4	Rattus norvegicus	62-66
10467457-3	1999	The increased liver lipid peroxidation, and decreased liver vitamin C concentrations observed after CCl4 treatment were significantly prevented by PHU administration.	N-phenylurea	147-150	C-C motif chemokine ligand 4	Rattus norvegicus	100-104
9862022-1	1998	The effect of oral administration of a preparation of human urine (PHU) on the progression of acute liver injury was examined in rats intoxicated with carbon tetrachloride (CCl4) and alpha-naphthylisothiocyanate (ANIT) PHU protected the liver from CCl4-induced injury as judged by morphological and biochemical observations.	N-phenylurea	67-70	C-C motif chemokine ligand 4	Rattus norvegicus	173-177
24920432-0	2014	Engineering the metabolism of the phenylurea herbicide chlortoluron in genetically modified Arabidopsis thaliana plants expressing the mammalian cytochrome P450 enzyme CYP1A2.	N-phenylurea	34-44	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	168-174
9089338-6	1997	Further investigation of the structure-activity profile following modification of the substituted phenylurea moiety appended off the lysine revealed that moving certain substituents, e.g. nitro or acetyl, from the 2- or 3-position on the phenyl ring to the 4-position, a relatively minor and subtle structural modification within the tetrapeptide, resulted in loss of CCK-A receptor selectivity and development of a trend toward CCK-B selectivity.	N-phenylurea	98-108	cholecystokinin A receptor	Homo sapiens	368-382
9089338-6	1997	Further investigation of the structure-activity profile following modification of the substituted phenylurea moiety appended off the lysine revealed that moving certain substituents, e.g. nitro or acetyl, from the 2- or 3-position on the phenyl ring to the 4-position, a relatively minor and subtle structural modification within the tetrapeptide, resulted in loss of CCK-A receptor selectivity and development of a trend toward CCK-B selectivity.	N-phenylurea	98-108	cholecystokinin B receptor	Homo sapiens	429-434
33746779-7	2021	Reduced muscle glycogen content at hatching of the pHu+ was concomitant with higher activation by phosphorylation of S6 kinase 1/ribosomal protein S6 pathway, known to activate protein synthesis in chicken muscle.	N-phenylurea	51-54	ribosomal protein S6	Gallus gallus	129-149
32210078-0	2020	Design, Synthesis and Biological Evaluation of Phenyl Urea Derivatives as IDO1 Inhibitors.	N-phenylurea	47-58	indoleamine 2,3-dioxygenase 1	Mus musculus	74-78
32210078-4	2020	Among them, the three phenyl urea derivatives i12, i23, i24 as showed potent IDO1 inhibition, with IC50 values of 0.1-0.6 muM and no compound exhibited TDO inhibitory activity.	N-phenylurea	22-33	indoleamine 2,3-dioxygenase 1	Mus musculus	77-81
31230150-5	2019	Under optimized conditions, response to phenylurea herbicides is linear in the 2.0-100 ng mL-1 concentration range for water samples, and 5.0-100 ng g-1 for leaf lettuces.	N-phenylurea	40-50	L1 cell adhesion molecule	Mus musculus	90-94
29982075-7	2018	The MYH7, UGP2, H2AFJ and VDAC3 were identified as potential indicators of pHu variations.	N-phenylurea	75-78	myosin-7	Bos taurus	4-8
29982075-7	2018	The MYH7, UGP2, H2AFJ and VDAC3 were identified as potential indicators of pHu variations.	N-phenylurea	75-78	UDP-glucose pyrophosphorylase 2	Bos taurus	10-14
29982075-7	2018	The MYH7, UGP2, H2AFJ and VDAC3 were identified as potential indicators of pHu variations.	N-phenylurea	75-78	H2A.J histone	Bos taurus	16-21
29982075-7	2018	The MYH7, UGP2, H2AFJ and VDAC3 were identified as potential indicators of pHu variations.	N-phenylurea	75-78	voltage-dependent anion-selective channel protein 3	Bos taurus	26-31
29982075-8	2018	CALM and NNT appeared to be interesting proteins to understand the metabolic pathways behind pHu.	N-phenylurea	93-96	calmodulin	Bos taurus	0-4
27454150-9	2016	FPR2 modulators include phenylurea, bridged spiro[2.4]heptane ester, naphthalene, aminotriazole, polycyclic pyrrolidine-2,5-dione, imidazolidine-2,4-dione, (2-ureidoacetamido)alkyl, amide, oxazolyl-methylether, oxazole, thiazole, and crystalline potassium salt derivatives.	N-phenylurea	24-34	formyl peptide receptor 2	Homo sapiens	0-4
26707846-3	2016	As a follow-up of our previous studies, and by using molecular docking method, we designed and synthesized a new series of 9-anilinoacridines containing phenyl-urea moieties as potential novel dual Src and MEK inhibitors.	N-phenylurea	153-164	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	198-201
26707846-3	2016	As a follow-up of our previous studies, and by using molecular docking method, we designed and synthesized a new series of 9-anilinoacridines containing phenyl-urea moieties as potential novel dual Src and MEK inhibitors.	N-phenylurea	153-164	mitogen-activated protein kinase kinase 7	Homo sapiens	206-209
19002402-3	1997	Phthalate plasticisers, for example, may disrupt the pituitary control of gonadal functions; prenatal/larval exposure to synthetic estrogen impairs sex differentiation and neuroendocrine sexual determination of the central nervous system; phenylurea herbicides block the androgen receptor; the biotransformation of weakly estrogenic plant sterol components of paper mill wastewater (e.g. beta-sitosterol) may lead to androgenic compounds.	N-phenylurea	239-249	androgen receptor	Homo sapiens	271-288
34653805-8	2022	ST1-ET(-ES/NES) maximized pHu reduction and provided an alternative for dark-cutting prevention in cold weather.	N-phenylurea	26-29	nestin	Bos taurus	11-14
3188024-15	1988	Our findings indicate that Gin-1 cells are a useful model in which to study inducers of antioxidant enzymes in vitro and that the phenylurea compound EDU induces SOD and CAT activities both in vitro and in vivo.	N-phenylurea	130-140	gypsy retrotransposon integrase 1	Homo sapiens	27-32
3188024-15	1988	Our findings indicate that Gin-1 cells are a useful model in which to study inducers of antioxidant enzymes in vitro and that the phenylurea compound EDU induces SOD and CAT activities both in vitro and in vivo.	N-phenylurea	130-140	catalase	Homo sapiens	170-173
3705970-1	1986	Short-term effect of eight substituted phenylurea herbicides has been investigated on the induction of rat hepatic microsomal epoxide hydrolase activity using an HPLC method with unlabelled styrene oxide as substrate.	N-phenylurea	39-49	epoxide hydrolase 1	Rattus norvegicus	115-143
31888388-4	2021	The results indicated that insertion of phenylurea group with a linker at position C-28 of OA can increase the activity against VEGFR-2 significantly.	N-phenylurea	40-50	kinase insert domain receptor	Homo sapiens	128-135
30460410-4	2018	The resulting Fe3O4/KAP is shown to be a viable magnetic sorbent for various organic materials such as the phenylurea herbicides (PUHs), including metoxuron, monuron, chlortoluron, monolinuron and buturon, and also for various phthalates, polycyclic aromatic hydrocarbons and chlorophenols.	N-phenylurea	107-117	napsin A aspartic peptidase	Homo sapiens	20-23
29096286-5	2018	The haplotype [g.-995G:g.-311G:c.89A:c.154G:c.595G] was associated with pHu (P=0.024), glycolytic potential (P=0.040) and cathepsin B activity (P=0.086).	N-phenylurea	72-75	cathepsin B	Sus scrofa	122-133
28343382-4	2017	Some consistencies were found, by the common correlation of pHu with MyHC-IIa and MyHC-IIx.	N-phenylurea	60-63	myosin heavy chain 2	Bos taurus	69-77
28343382-4	2017	Some consistencies were found, by the common correlation of pHu with MyHC-IIa and MyHC-IIx.	N-phenylurea	60-63	myosin heavy chain 1	Bos taurus	82-90
27189888-0	2016	Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents.	N-phenylurea	20-30	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	43-68
25597706-4	2015	In the high-throughput screen of a compound library, we identified the phenylurea BX430 (1-(2,6-dibromo-4-isopropyl-phenyl)-3-(3-pyridyl)urea, molecular weight = 413), with antagonist properties on human P2X4-mediated calcium uptake.	N-phenylurea	71-81	purinergic receptor P2X 4	Homo sapiens	204-208
24920432-2	2014	Transgenic A. thaliana plants expressing CYP1A2 gene showed remarkable resistance to the phenylurea herbicide chlortoluron (CTU) supplemented either in plant growth medium or sprayed on foliar parts of the plants.	N-phenylurea	89-99	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	41-47
22578477-4	2012	PRKAG3 on SSC15 was associated with pHu.	N-phenylurea	36-39	protein kinase AMP-activated non-catalytic subunit gamma 3	Homo sapiens	0-6
19904270-3	2010	METHODS: A phenylurea-based small molecule inhibitor of XIAP, XIAP antagonist compound (XAC) 1396-11, was investigated preclincally to determine its ability to sensitise to clinically relevant cytotoxics, potentially allowing dose reduction while maintaining therapeutic efficacy.	N-phenylurea	11-21	X-linked inhibitor of apoptosis	Homo sapiens	56-60
19904270-3	2010	METHODS: A phenylurea-based small molecule inhibitor of XIAP, XIAP antagonist compound (XAC) 1396-11, was investigated preclincally to determine its ability to sensitise to clinically relevant cytotoxics, potentially allowing dose reduction while maintaining therapeutic efficacy.	N-phenylurea	11-21	X-linked inhibitor of apoptosis	Homo sapiens	62-66
21784029-7	2009	A pronounced CYP1A1 and CYP1A2 mRNA induction was given by the phenyl urea herbicide diuron and benzodiazole insecticide piperonylbutoxide, respectively.	N-phenylurea	63-74	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
21784029-7	2009	A pronounced CYP1A1 and CYP1A2 mRNA induction was given by the phenyl urea herbicide diuron and benzodiazole insecticide piperonylbutoxide, respectively.	N-phenylurea	63-74	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	24-30
24148447-1	2013	A direct Laser Photo-Induced Fluorescence (DL-PIF) method is developed for the determination of two phenylurea pesticides, namely fenuron and diflubenzuron.	N-phenylurea	100-110	PIF1 5'-to-3' DNA helicase	Homo sapiens	46-49
24148447-4	2013	The analytical performances of this method for the determination of both pesticides are satisfactory in comparison to other classical PIF methods published for the determination of phenylurea pesticides.	N-phenylurea	181-191	PIF1 5'-to-3' DNA helicase	Homo sapiens	134-137
21277205-0	2011	Discovery of substituted phenyl urea derivatives as novel long-acting beta2-adrenoreceptor agonists.	N-phenylurea	25-36	adrenoceptor beta 2	Homo sapiens	70-90