PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26522449-0	2015	The azetidine derivative, KHG26792 protects against ATP-induced activation of NFAT and MAPK pathways through P2X7 receptor in microglia.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	26-34	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	109-122
29966582-5	2018	Treatment of KHG26792 significantly attenuated MPP+-induced changes in the protein levels of Bcl-2 and Bax together with efficient suppression of MPP+-induced activation of caspase-3 activity.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	13-21	BCL2 apoptosis regulator	Homo sapiens	93-98
29966582-5	2018	Treatment of KHG26792 significantly attenuated MPP+-induced changes in the protein levels of Bcl-2 and Bax together with efficient suppression of MPP+-induced activation of caspase-3 activity.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	103-106
29966582-5	2018	Treatment of KHG26792 significantly attenuated MPP+-induced changes in the protein levels of Bcl-2 and Bax together with efficient suppression of MPP+-induced activation of caspase-3 activity.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	13-21	caspase 3	Homo sapiens	173-182
29966582-8	2018	Moreover, the protective effect of KHG26792 is mediated through regulation of glutathione peroxidase and GDNF levels.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	35-43	glial cell derived neurotrophic factor	Homo sapiens	105-109
27756444-1	2016	We recently reported the anti-inflammatory effects of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride (KHG26792) on the ATP-induced activation of the NFAT and MAPK pathways through the P2X7 receptor in microglia.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	54-111	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	195-208
27756444-1	2016	We recently reported the anti-inflammatory effects of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride (KHG26792) on the ATP-induced activation of the NFAT and MAPK pathways through the P2X7 receptor in microglia.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	113-121	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	195-208
27756444-3	2016	The administration of KHG26792 significantly reduced the hypoxia-induced expression and activity of caspase-3 in BV-2 microglial cells.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	22-30	caspase 3	Mus musculus	100-109
29111328-0	2018	3-(Naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride attenuates NLRP3 inflammasome-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglial cells.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-57	NLR family, pyrin domain containing 3	Mus musculus	69-74
29111328-9	2018	Furthermore, KHG26792 successfully blocked LPS-activated adenosine triphosphate (ATP) level, likely through the purinergic receptor P2X ligand-gated ion channel 7 (P2X7) receptor.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	13-21	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	112-162
29111328-9	2018	Furthermore, KHG26792 successfully blocked LPS-activated adenosine triphosphate (ATP) level, likely through the purinergic receptor P2X ligand-gated ion channel 7 (P2X7) receptor.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	13-21	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	164-178
29111328-10	2018	Our results suggest that the anti-inflammatory functions of KHG26792 may be, at least in part, due to regulation of the P2X7R/NLRP3-mediated signaling pathway during microglial activation.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	60-68	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	120-125
29111328-10	2018	Our results suggest that the anti-inflammatory functions of KHG26792 may be, at least in part, due to regulation of the P2X7R/NLRP3-mediated signaling pathway during microglial activation.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	60-68	NLR family, pyrin domain containing 3	Mus musculus	126-131
29065971-1	2017	We aimed to assess the anti-inflammatory and antioxidative properties of KHG26792, a novel azetidine derivative, in amyloid beta (Abeta)-treated primary microglial cells.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	73-81	amyloid beta precursor protein	Homo sapiens	130-135
29065971-2	2017	KHG26792 attenuated the Abeta-induced production of inflammatory mediators such as IL-6, IL-1beta, TNF-alpha, and nitric oxide.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-8	amyloid beta precursor protein	Homo sapiens	24-29
29065971-2	2017	KHG26792 attenuated the Abeta-induced production of inflammatory mediators such as IL-6, IL-1beta, TNF-alpha, and nitric oxide.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-8	interleukin 6	Homo sapiens	83-87
29065971-2	2017	KHG26792 attenuated the Abeta-induced production of inflammatory mediators such as IL-6, IL-1beta, TNF-alpha, and nitric oxide.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-8	interleukin 1 beta	Homo sapiens	89-97
29065971-2	2017	KHG26792 attenuated the Abeta-induced production of inflammatory mediators such as IL-6, IL-1beta, TNF-alpha, and nitric oxide.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-8	tumor necrosis factor	Homo sapiens	99-108
29065971-4	2017	The effects of KHG26792 against the Abeta-induced increases in inflammatory cytokine levels and oxidative stress were achieved by increasing the phosphorylation of Akt/ GSK-3beta signaling and by decreasing the Abeta-induced translocation of NF-kappaB.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	15-23	amyloid beta precursor protein	Homo sapiens	36-41
29065971-4	2017	The effects of KHG26792 against the Abeta-induced increases in inflammatory cytokine levels and oxidative stress were achieved by increasing the phosphorylation of Akt/ GSK-3beta signaling and by decreasing the Abeta-induced translocation of NF-kappaB.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	15-23	AKT serine/threonine kinase 1	Homo sapiens	164-167
29065971-4	2017	The effects of KHG26792 against the Abeta-induced increases in inflammatory cytokine levels and oxidative stress were achieved by increasing the phosphorylation of Akt/ GSK-3beta signaling and by decreasing the Abeta-induced translocation of NF-kappaB.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	15-23	glycogen synthase kinase 3 beta	Homo sapiens	169-178
29065971-4	2017	The effects of KHG26792 against the Abeta-induced increases in inflammatory cytokine levels and oxidative stress were achieved by increasing the phosphorylation of Akt/ GSK-3beta signaling and by decreasing the Abeta-induced translocation of NF-kappaB.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	15-23	amyloid beta precursor protein	Homo sapiens	211-216
29065971-4	2017	The effects of KHG26792 against the Abeta-induced increases in inflammatory cytokine levels and oxidative stress were achieved by increasing the phosphorylation of Akt/ GSK-3beta signaling and by decreasing the Abeta-induced translocation of NF-kappaB.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	15-23	nuclear factor kappa B subunit 1	Homo sapiens	242-251
29065971-6	2017	Nevertheless, further investigations of cellular signaling are required to clarify the in vivo effects of KHG26792 against Abeta-induced toxicity.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	106-114	amyloid beta precursor protein	Homo sapiens	123-128
26522449-3	2015	Here, we have investigated the effects of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride (KHG26792) on ATP-induced activation of NFAT and MAPK through P2X7 receptor in the BV-2 mouse microglial cell line.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	101-109	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	162-175
26522449-4	2015	KHG26792 decreased ATP-induced TNF-alpha release from BV-2 microglia by suppressing, at least partly, P2X7 receptor stimulation.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-8	tumor necrosis factor	Mus musculus	31-40
26522449-4	2015	KHG26792 decreased ATP-induced TNF-alpha release from BV-2 microglia by suppressing, at least partly, P2X7 receptor stimulation.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-8	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	102-115
26522449-5	2015	KHG26792 also inhibited the ATP-induced increase in IL-6, PGE2, NO, ROS, CXCL2, and CCL3.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-8	interleukin 6	Mus musculus	52-56
26522449-5	2015	KHG26792 also inhibited the ATP-induced increase in IL-6, PGE2, NO, ROS, CXCL2, and CCL3.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-8	chemokine (C-X-C motif) ligand 2	Mus musculus	73-78
26522449-5	2015	KHG26792 also inhibited the ATP-induced increase in IL-6, PGE2, NO, ROS, CXCL2, and CCL3.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-8	chemokine (C-C motif) ligand 3	Mus musculus	84-88
26522449-7	2015	KHG26792 inhibited an ATP-induced increase in iNOS protein and ERK phosphorylation.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-8	nitric oxide synthase 2, inducible	Mus musculus	46-50
24976765-4	2014	KHG26792 activated extracellular signal-regulated kinase (ERK), whereas an ERK pathway inhibitor, PD98059, rescued KHG26792-induced hypopigmentation.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-8	mitogen-activated protein kinase 1	Mus musculus	19-56
24976765-4	2014	KHG26792 activated extracellular signal-regulated kinase (ERK), whereas an ERK pathway inhibitor, PD98059, rescued KHG26792-induced hypopigmentation.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-8	mitogen-activated protein kinase 1	Mus musculus	58-61
24976765-5	2014	These results suggest that KHG26792 decreases melanin production via ERK activation.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	27-35	mitogen-activated protein kinase 1	Mus musculus	69-72