PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17908202-2	2007	The Sac1 lipid phosphatase regulates endoplasmic reticulum (ER) and Golgi phosphatidylinositol-4-phosphate [PI(4)P] in response to nutrient levels and cell growth stages.	pi(4)p	108-114	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	4-8
20348433-8	2010	Additionally, we find that POL and PLL1 directly bind to multiple lipids and that POL is catalytically activated by phosphatidylinositol (4) phosphate [PI(4)P] in vitro.	pi(4)p	152-158	Protein phosphatase 2C family protein	Arabidopsis thaliana	27-30
20348433-8	2010	Additionally, we find that POL and PLL1 directly bind to multiple lipids and that POL is catalytically activated by phosphatidylinositol (4) phosphate [PI(4)P] in vitro.	pi(4)p	152-158	Protein phosphatase 2C family protein	Arabidopsis thaliana	82-85
20348433-9	2010	Based on these results, we propose that the upstream receptors in the CLE/WOX signaling pathways may function to either limit PI(4)P availability or antagonize PI(4)P stimulation of POL/PLL1.	pi(4)p	160-166	Protein phosphatase 2C family protein	Arabidopsis thaliana	182-185
19795375-2	2010	Here we extend the knowledge of the mechanism of action of Rab31 by demonstrating its interaction with OCRL-1, a phosphatidylinositol 4,5-diphosphate 5-phosphatase (PI(4,5)P(2) 5-phosphatase) that regulates the levels of PI(4,5)P(2) and PI(4)P, molecules involved in transport and Golgi/TGN organization.	pi(4)p	237-243	RAB31, member RAS oncogene family	Homo sapiens	59-64
19795375-2	2010	Here we extend the knowledge of the mechanism of action of Rab31 by demonstrating its interaction with OCRL-1, a phosphatidylinositol 4,5-diphosphate 5-phosphatase (PI(4,5)P(2) 5-phosphatase) that regulates the levels of PI(4,5)P(2) and PI(4)P, molecules involved in transport and Golgi/TGN organization.	pi(4)p	237-243	OCRL inositol polyphosphate-5-phosphatase	Homo sapiens	103-109
18281508-5	2008	RHD4 displayed a preference for phosphatidylinositol-4-phosphate [PI(4)P] in vitro, and rhd4-1 roots accumulated higher levels of PI(4)P in vivo.	pi(4)p	66-72	Phosphoinositide phosphatase family protein	Arabidopsis thaliana	0-4
18281508-5	2008	RHD4 displayed a preference for phosphatidylinositol-4-phosphate [PI(4)P] in vitro, and rhd4-1 roots accumulated higher levels of PI(4)P in vivo.	pi(4)p	130-136	Phosphoinositide phosphatase family protein	Arabidopsis thaliana	88-92
18281508-6	2008	In wild-type root hairs, PI(4)P accumulated primarily in a tip-localized plasma membrane domain, but in rhd4-1 mutants, significant levels of PI(4)P were detected associated with internal membranes.	pi(4)p	142-148	Phosphoinositide phosphatase family protein	Arabidopsis thaliana	104-108
18281508-8	2008	We propose that RHD4 is selectively recruited to RabA4b-labeled membranes that are involved in polarized expansion of root hair cells and that, in conjunction with the phosphoinositide kinase PI-4Kbeta1, RHD4 regulates the accumulation of PI(4)P on membrane compartments at the tips of growing root hairs.	pi(4)p	239-245	Phosphoinositide phosphatase family protein	Arabidopsis thaliana	16-20
20348433-9	2010	Based on these results, we propose that the upstream receptors in the CLE/WOX signaling pathways may function to either limit PI(4)P availability or antagonize PI(4)P stimulation of POL/PLL1.	pi(4)p	160-166	poltergeist like 1	Arabidopsis thaliana	186-190
19542373-3	2009	Herein, we show that the positively charged residues of the BRS enable this region of CD3 epsilon to complex a subset of acidic phospholipids, including PI(3)P, PI(4)P, PI(5)P, PI(3,4,5)P(3), and PI(4,5)P(2).	pi(4)p	161-167	CD3 antigen, epsilon polypeptide	Mus musculus	86-89
18390907-10	2008	Conversion of PI(4,5)P(2) to PI(4)P by a rapamycin-inducible PI(4,5)P(2) 5-phosphatase inhibited TRPV6 currents in whole-cell experiments.	pi(4)p	29-35	transient receptor potential cation channel subfamily V member 6	Homo sapiens	97-102
18281508-8	2008	We propose that RHD4 is selectively recruited to RabA4b-labeled membranes that are involved in polarized expansion of root hair cells and that, in conjunction with the phosphoinositide kinase PI-4Kbeta1, RHD4 regulates the accumulation of PI(4)P on membrane compartments at the tips of growing root hairs.	pi(4)p	239-245	RAB GTPase homolog A4B	Arabidopsis thaliana	49-55
18281508-8	2008	We propose that RHD4 is selectively recruited to RabA4b-labeled membranes that are involved in polarized expansion of root hair cells and that, in conjunction with the phosphoinositide kinase PI-4Kbeta1, RHD4 regulates the accumulation of PI(4)P on membrane compartments at the tips of growing root hairs.	pi(4)p	239-245	phosphatidylinositol 4-OH kinase beta1	Arabidopsis thaliana	192-202
18281508-8	2008	We propose that RHD4 is selectively recruited to RabA4b-labeled membranes that are involved in polarized expansion of root hair cells and that, in conjunction with the phosphoinositide kinase PI-4Kbeta1, RHD4 regulates the accumulation of PI(4)P on membrane compartments at the tips of growing root hairs.	pi(4)p	239-245	Phosphoinositide phosphatase family protein	Arabidopsis thaliana	204-208
17909536-4	2007	rSac3 displays PIPPase activity with PI(3)P, PI(4)P and PI(3,5)P(2) as substrates in vitro, and a mutation in the catalytic core of the Sac domain abolishes its enzymatic activity.	pi(4)p	45-51	FIG4 phosphoinositide 5-phosphatase	Rattus norvegicus	0-5
17908202-6	2007	Starvation-induced shuttling of Sac1p to the Golgi specifically eliminates a pool of PI(4)P generated by the lipid kinase Pik1p.	pi(4)p	85-91	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	32-37
16888807-8	2007	Instead, the kinetic data are consistent with a model in which mPIP5K-Ibeta initially binds to the lipid micelle and subsequently binds the PI(4)P substrate.	pi(4)p	140-146	phosphatidylinositol-4-phosphate 5-kinase, type 1 beta	Mus musculus	63-75
17555516-3	2007	In human epithelial HeLa cells, both PI4KIIalpha and PI4KIIbeta isoforms are corecruited with Met around InlB-coated beads or wild-type Listeria during the early steps of internalization, and phosphatidylinositol 4-phosphate [PI(4)P] is detected at the entry site.	pi(4)p	226-232	phosphatidylinositol 4-kinase type 2 beta	Homo sapiens	53-63
17356130-5	2007	The NH(2) terminus of SGK1, which shares sequence homology with the phosphoinositide 3-phosphate [PI(3)P] binding domain of SGK3, binds phosphoinositides in protein lipid overlay assays, interacting specifically with PI(3)P, PI(4)P, and PI(5)P, but not with PI(3,4,5)P(3).	pi(4)p	225-231	serum/glucocorticoid regulated kinase 1	Homo sapiens	22-26
17356130-5	2007	The NH(2) terminus of SGK1, which shares sequence homology with the phosphoinositide 3-phosphate [PI(3)P] binding domain of SGK3, binds phosphoinositides in protein lipid overlay assays, interacting specifically with PI(3)P, PI(4)P, and PI(5)P, but not with PI(3,4,5)P(3).	pi(4)p	225-231	serum/glucocorticoid regulated kinase family member 3	Homo sapiens	124-128
16888807-9	2007	In addition, the kinetics indicate substrate inhibition, suggesting that mPIP5K-Ibeta contains an inhibitory PI(4)P-binding site.	pi(4)p	109-115	phosphatidylinositol-4-phosphate 5-kinase, type 1 beta	Mus musculus	73-85
16888807-10	2007	These results suggest a model in which mPIP5K-Ibeta is surrounded by PI(4)P, but is unable to catalyze its conversion to PI(4,5)P2 unless PA is bound.	pi(4)p	69-75	phosphatidylinositol-4-phosphate 5-kinase, type 1 beta	Mus musculus	39-51
15870270-4	2005	In migrating primary mouse embryonic fibroblasts (MEFs) from Ajuba(-/-) mice the level of PI(4,5)P2 was decreased with a corresponding increase in the level of the substrate PI(4)P.	pi(4)p	174-180	ajuba LIM protein	Mus musculus	61-66
17954247-2	2007	In mammalian cells, PI(4,5)P(2) is synthesized predominantly by phosphatidylinositol 4-phosphate [PI(4)P] 5-kinase (PIP5K) through phosphorylation of PI(4)P at the D-5 position of the inositol ring.	pi(4)p	98-104	phosphoinositide kinase, FYVE-type zinc finger containing	Homo sapiens	116-121
16081809-4	2005	The PB region of Rac1 showed strong phospholipid interaction with PI(3)P, PI(4)P, PI(5)P, PI(3,4,5)P3, and phosphatidic acid, however, that of Rac2 did not.	pi(4)p	74-80	Rac family small GTPase 1	Homo sapiens	17-21
15659215-4	2005	Exogenous, myristoylated NCS-1 stimulated nerve ending phosphatidylinositol 4-phosphate [PI(4)P] synthesis, but non-myristoylated-NCS-1 did not.	pi(4)p	89-95	neuronal calcium sensor 1	Homo sapiens	25-30
15659215-5	2005	The N-terminal peptide of NCS-1 interfered with PI(4)P synthesis, and with spontaneous and Ca(2+)-evoked release of both [(3)H]-norepinephrine (NA) and [(14)C]-glutamate (glu) in a concentration-dependent manner.	pi(4)p	48-54	neuronal calcium sensor 1	Homo sapiens	26-31
15659215-6	2005	An antibody raised against the N-terminal of NCS-1 inhibited perforated nerve ending PI(4)P synthesis, but the C-terminal antibody had no effects.	pi(4)p	85-91	neuronal calcium sensor 1	Homo sapiens	45-50
14607934-7	2003	Our results indicate that PI(4)P, produced by the Golgi-localized PI4Kbeta, is the rate-limiting factor in the synthesis of the pool of PI(4,5)P(2) that serves as substrate for the generation of lipid-derived second messengers in FcepsilonRI-triggered cells.	pi(4)p	26-32	phosphatidylinositol 4-kinase beta	Rattus norvegicus	66-74
12914695-5	2003	This AP-1 binding defect is rescued by adding back PI(4)P.	pi(4)p	51-57	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	5-9
12857747-5	2003	Activation by exogenous PI(4,5)P2 is more apparent with PI(3,4)P2 as a substrate than with PI(3,4,5)P3, probably because hydrolysis of PI(3,4)P2 yields PI(4)P, which is not an activator.	pi(4)p	152-158	peptidase inhibitor 3	Homo sapiens	56-65
12857747-5	2003	Activation by exogenous PI(4,5)P2 is more apparent with PI(3,4)P2 as a substrate than with PI(3,4,5)P3, probably because hydrolysis of PI(3,4)P2 yields PI(4)P, which is not an activator.	pi(4)p	152-158	peptidase inhibitor 3	Homo sapiens	135-144
12914695-7	2003	We propose that PI4KIIalpha establishes the Golgi"s unique lipid-defined organelle identity by generating PI(4)P-rich domains that specify the docking of the AP-1 coat machinery.	pi(4)p	106-112	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	158-162
8394081-7	1993	Thrombin stimulation of genistein-pretreated cells intensified this tendency, i.e. a further increase in the amount of PI(4)P and a decrease in the amount of PI(4,5)P2 in an inversely proportional manner.	pi(4)p	119-125	coagulation factor II, thrombin	Homo sapiens	0-8
11704666-3	2002	Because phosphatidylinositol 4-kinase (PI4K)-mediated phosphatidylinositol 4-phosphate (PI(4)P) production has been suggested to regulate biosynthetic traffic in yeast and mammalian cells, we have examined the role of PI4Kbeta in protein delivery in polarized MDCK cells, at different levels of the biosynthetic pathway.	pi(4)p	88-94	phosphatidylinositol 4-kinase beta	Homo sapiens	218-226
25724886-3	2015	Lipid kinases that generate phosphatidylinositol 4-phosphate [PI(4)P] at the Golgi (Pik1p) or PI(4,5)P2 at the plasma membrane (PM) (Mss4p and Stt4p) were required for filamentous-growth MAPK pathway signaling.	pi(4)p	62-68	1-phosphatidylinositol 4-kinase	Saccharomyces cerevisiae S288C	84-89
25724886-3	2015	Lipid kinases that generate phosphatidylinositol 4-phosphate [PI(4)P] at the Golgi (Pik1p) or PI(4,5)P2 at the plasma membrane (PM) (Mss4p and Stt4p) were required for filamentous-growth MAPK pathway signaling.	pi(4)p	62-68	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	133-138
34796518-8	2022	In addition, the level of PI(4)P and PI(3,4,5)P decreased and phosphorylation of P-AKT and P-mTOR were downregulated in FAPP2 knock-down cells.	pi(4)p	26-32	pleckstrin homology domain containing A8	Homo sapiens	120-125
34821358-3	2022	The recently characterized lipid transfer protein TMEM24 dynamically localize to ER-PM contact sites and provide phosphatidylinositol, a precursor of PI(4)P and PI(4,5)P2, to the plasma membrane.	pi(4)p	150-156	C2CD2 like	Homo sapiens	50-56
34796518-9	2022	In summary, our results show that decreased expression of FAPP2 inhibited cell proliferation, resulted in the sub-G1 phase accumulation of T-ALL cells, and enhanced autophagy of T-ALL cells, likely mediated by PI(4)P, PI(3,4,5)P, and PI3K/AKT/mTOR pathway.	pi(4)p	210-216	pleckstrin homology domain containing A8	Homo sapiens	58-63
33857182-5	2021	ORP3 binds PI(4)P by the residues around tunnel entrance and in the hydrophobic pocket, whereas it lacks sterol binding due to the narrow hydrophobic tunnel.	pi(4)p	11-17	oxysterol binding protein like 3	Homo sapiens	0-4
34320354-5	2021	Mechanistically, the loss of SAC1 results in aberrant accumulation of phosphatidylinositol-4-phosphate (PI(4)P) on Salmonella-containing autophagosomes, thus facilitating recruitment of SteA, a PI(4)P-binding Salmonella effector protein, which impedes lysosomal fusion.	pi(4)p	104-110	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	29-33
34320354-5	2021	Mechanistically, the loss of SAC1 results in aberrant accumulation of phosphatidylinositol-4-phosphate (PI(4)P) on Salmonella-containing autophagosomes, thus facilitating recruitment of SteA, a PI(4)P-binding Salmonella effector protein, which impedes lysosomal fusion.	pi(4)p	194-200	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	29-33
35164565-13	2022	The significance of this work is in identifying a plasma membrane phospholipid that has an infection-specific role, which is attributed to the loss of plasma membrane PI(4)P resulting in beta(1,3)-glucan unmasking.	pi(4)p	167-173	UDP glycosyltransferase 1 family, polypeptide A10	Mus musculus	187-195
34571985-2	2021	GOLPH3 binding to Golgi membranes depends on phosphatidylinositol 4-phosphate (PI(4)P) and regulates Golgi architecture and vesicle trafficking.	pi(4)p	79-85	sauron	Drosophila melanogaster	0-6
33857182-7	2021	In contrast, the PI(4)P-binding site mutant of ORP3 did not complement the OSH knockout cells.	pi(4)p	17-23	oxysterol binding protein like 3	Homo sapiens	47-51
33037125-5	2020	We show that cbe mutation impairs localization of the Phosphatidylinositol 4-phosphate [PI(4)P] binding protein Golgi phosphoprotein 3 (GOLPH3) and maintenance of centralspindlin at the cell equator of telophase cells.	pi(4)p	88-94	sauron	Drosophila melanogaster	112-134
33037125-5	2020	We show that cbe mutation impairs localization of the Phosphatidylinositol 4-phosphate [PI(4)P] binding protein Golgi phosphoprotein 3 (GOLPH3) and maintenance of centralspindlin at the cell equator of telophase cells.	pi(4)p	88-94	sauron	Drosophila melanogaster	136-142
32492390-3	2020	(2020) now demonstrate that PI(4)P-containing Golgi-derived vesicles also modulate mitochondrial fission, driven by Arf1 and PI(4)KIIIbeta activity, identifying a new organelle contact involved in maintaining mitochondrial homeostasis.	pi(4)p	28-34	ADP ribosylation factor 1	Homo sapiens	116-120
32294532-11	2020	Studies with subgenomic HCV replicons and an expression system revealed that C19orf66 expression impairs HCV-induced elevation of PI(4)P, alters the morphology of the viral replication organelle designated membranous web and thereby targets viral RNA replication.	pi(4)p	130-136	shiftless antiviral inhibitor of ribosomal frameshifting	Homo sapiens	77-85
32086008-1	2020	Phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3] is a phosphorylated derivative of phosphatidylinositol 4-phosphate [PI(4)P] and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], which recruit and activate AKT in the plasma membrane (PM) to promote cellular survival.	pi(4)p	123-129	thymoma viral proto-oncogene 1	Mus musculus	213-216
32086008-2	2020	ORP5 anchors at the endoplasmic reticulum (ER)-PM contact sites and acts as a PI(4)P and PI(4,5)P2/phosphatidylserine (PS) exchanger.	pi(4)p	78-84	oxysterol binding protein-like 5	Mus musculus	0-4
32492390-3	2020	(2020) now demonstrate that PI(4)P-containing Golgi-derived vesicles also modulate mitochondrial fission, driven by Arf1 and PI(4)KIIIbeta activity, identifying a new organelle contact involved in maintaining mitochondrial homeostasis.	pi(4)p	28-34	phosphatidylinositol 4-kinase beta	Homo sapiens	125-138
32269127-9	2020	Reduction in the PI(4)P level due to chemical inhibition in plant protoplasts; depletion of two PI(4)P kinases, Stt4p and Pik1p; or sequestration of free PI(4)P via expression of a PI(4)P-binding protein in yeast strongly inhibited TBSV replication.	pi(4)p	17-23	1-phosphatidylinositol 4-kinase STT4	Saccharomyces cerevisiae S288C	112-117
32269127-9	2020	Reduction in the PI(4)P level due to chemical inhibition in plant protoplasts; depletion of two PI(4)P kinases, Stt4p and Pik1p; or sequestration of free PI(4)P via expression of a PI(4)P-binding protein in yeast strongly inhibited TBSV replication.	pi(4)p	17-23	1-phosphatidylinositol 4-kinase	Saccharomyces cerevisiae S288C	122-127
32193326-4	2020	Here, we found that microdomains of phosphatidylinositol 4-phosphate [PI(4)P] on trans-Golgi network (TGN) vesicles were recruited to mitochondria-ER contact sites and could drive mitochondrial division downstream of Drp1.	pi(4)p	70-76	dynamin 1 like	Homo sapiens	217-221
32193326-5	2020	The loss of the small guanosine triphosphatase ADP-ribosylation factor 1 (Arf1) or its effector, phosphatidylinositol 4-kinase IIIbeta [PI(4)KIIIbeta], in different mammalian cell lines prevented PI(4)P generation and led to a hyperfused and branched mitochondrial network marked with extended mitochondrial constriction sites.	pi(4)p	196-202	ADP ribosylation factor 1	Homo sapiens	47-72
31034465-1	2019	PIK3C2A is a class II member of the phosphoinositide 3-kinase (PI3K) family that catalyzes the phosphorylation of phosphatidylinositol (PI) into PI(3)P and the phosphorylation of PI(4)P into PI(3,4)P2.	pi(4)p	179-185	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	0-7
31913757-4	2020	TGFbeta induced rapid decreases in PI(4,5)P2 at the plasma membrane (PM) with increases in PI(4)P, followed by increases in PI(3,4)P2, in a TGFbeta receptor kinase ALK5-dependent manner.	pi(4)p	91-97	transforming growth factor alpha	Homo sapiens	0-7
31339948-6	2019	In yeast, the subcellular localization of SopF is dependent on the activity of Mss4, a phosphatidylinositol 4-phosphate 5-kinase that generates PI(4,5)P2 from PI(4)P, indicating that membrane recruitment of SopF requires specific phospholipids.	pi(4)p	159-165	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	79-83
32187552-3	2020	We report that in podocytes, either APOL1 C-terminal helix truncation (APOL1Delta) or APOL3 deletion (APOL3KO) induces similar actomyosin reorganization linked to the inhibition of phosphatidylinositol-4-phosphate [PI(4)P] synthesis by the Golgi PI(4)-kinase IIIB (PI4KB).	pi(4)p	215-221	apolipoprotein L1	Homo sapiens	36-41
31813476-11	2020	We demonstrate that Coq1 an enzyme required for coenzyme Q synthesis (also involved in sterol metabolism indirectly), Sac1, and Stt4 the enzymes governing PI(4)P level modify Sch A toxicity and finally propose Sch A disrupts sterol/PI(4)P exchange between membranes by occupying the sterol/PI(4)P binding pocket in Osh2.	pi(4)p	155-161	trans-hexaprenyltranstransferase	Saccharomyces cerevisiae S288C	20-24
31813476-11	2020	We demonstrate that Coq1 an enzyme required for coenzyme Q synthesis (also involved in sterol metabolism indirectly), Sac1, and Stt4 the enzymes governing PI(4)P level modify Sch A toxicity and finally propose Sch A disrupts sterol/PI(4)P exchange between membranes by occupying the sterol/PI(4)P binding pocket in Osh2.	pi(4)p	155-161	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	118-122
31813476-11	2020	We demonstrate that Coq1 an enzyme required for coenzyme Q synthesis (also involved in sterol metabolism indirectly), Sac1, and Stt4 the enzymes governing PI(4)P level modify Sch A toxicity and finally propose Sch A disrupts sterol/PI(4)P exchange between membranes by occupying the sterol/PI(4)P binding pocket in Osh2.	pi(4)p	155-161	1-phosphatidylinositol 4-kinase STT4	Saccharomyces cerevisiae S288C	128-132
31813476-11	2020	We demonstrate that Coq1 an enzyme required for coenzyme Q synthesis (also involved in sterol metabolism indirectly), Sac1, and Stt4 the enzymes governing PI(4)P level modify Sch A toxicity and finally propose Sch A disrupts sterol/PI(4)P exchange between membranes by occupying the sterol/PI(4)P binding pocket in Osh2.	pi(4)p	232-238	trans-hexaprenyltranstransferase	Saccharomyces cerevisiae S288C	20-24
31813476-11	2020	We demonstrate that Coq1 an enzyme required for coenzyme Q synthesis (also involved in sterol metabolism indirectly), Sac1, and Stt4 the enzymes governing PI(4)P level modify Sch A toxicity and finally propose Sch A disrupts sterol/PI(4)P exchange between membranes by occupying the sterol/PI(4)P binding pocket in Osh2.	pi(4)p	232-238	1-phosphatidylinositol 4-kinase STT4	Saccharomyces cerevisiae S288C	128-132
31813476-11	2020	We demonstrate that Coq1 an enzyme required for coenzyme Q synthesis (also involved in sterol metabolism indirectly), Sac1, and Stt4 the enzymes governing PI(4)P level modify Sch A toxicity and finally propose Sch A disrupts sterol/PI(4)P exchange between membranes by occupying the sterol/PI(4)P binding pocket in Osh2.	pi(4)p	232-238	trans-hexaprenyltranstransferase	Saccharomyces cerevisiae S288C	20-24
31813476-11	2020	We demonstrate that Coq1 an enzyme required for coenzyme Q synthesis (also involved in sterol metabolism indirectly), Sac1, and Stt4 the enzymes governing PI(4)P level modify Sch A toxicity and finally propose Sch A disrupts sterol/PI(4)P exchange between membranes by occupying the sterol/PI(4)P binding pocket in Osh2.	pi(4)p	232-238	1-phosphatidylinositol 4-kinase STT4	Saccharomyces cerevisiae S288C	128-132
31484747-2	2019	VAPs are known to recruit lipid transfer proteins to the ER, including oxysterol binding protein (OSBP), which has been previously shown to be necessary for cholesterol delivery to the HCV replication organelle in exchange for phosphatidylinositol 4-phosphate [PI(4)P].	pi(4)p	261-267	oxysterol binding protein	Homo sapiens	71-96
31484747-2	2019	VAPs are known to recruit lipid transfer proteins to the ER, including oxysterol binding protein (OSBP), which has been previously shown to be necessary for cholesterol delivery to the HCV replication organelle in exchange for phosphatidylinositol 4-phosphate [PI(4)P].	pi(4)p	261-267	oxysterol binding protein	Homo sapiens	98-102
31484747-5	2019	We propose that Nir2 functions to replenish phosphoinositides at the HCV replication organelle to maintain elevated steady-state levels of PI(4)P, which is removed by OSBP.	pi(4)p	139-145	phosphatidylinositol transfer protein membrane associated 1	Homo sapiens	16-20
31484747-5	2019	We propose that Nir2 functions to replenish phosphoinositides at the HCV replication organelle to maintain elevated steady-state levels of PI(4)P, which is removed by OSBP.	pi(4)p	139-145	oxysterol binding protein	Homo sapiens	167-171
31484747-7	2019	Elevated levels of phosphatidylinositol 4-phosphate [PI(4)P] in HCV replication organelles (ROs) recruits lipid transfer proteins (LTPs), like oxysterol-binding protein (OSBP).	pi(4)p	53-59	oxysterol binding protein	Homo sapiens	143-168
31484747-7	2019	Elevated levels of phosphatidylinositol 4-phosphate [PI(4)P] in HCV replication organelles (ROs) recruits lipid transfer proteins (LTPs), like oxysterol-binding protein (OSBP).	pi(4)p	53-59	oxysterol binding protein	Homo sapiens	170-174
31484747-8	2019	OSBP exchanges PI(4)P with cholesterol, thus removing PI(4)P from the HCV RO.	pi(4)p	15-21	oxysterol binding protein	Homo sapiens	0-4
31484747-8	2019	OSBP exchanges PI(4)P with cholesterol, thus removing PI(4)P from the HCV RO.	pi(4)p	54-60	oxysterol binding protein	Homo sapiens	0-4
30590084-4	2019	ORP2 showed specific affinity for PI(4,5)P2, PI(3,4,5)P3 and PI(4)P, with suggestive Kd values in the muM range.	pi(4)p	61-67	oxysterol binding protein like 2	Homo sapiens	0-4
30543784-6	2019	When small proportions of the phosphoinositide PI(4)P were included in receptor SUVs (either with PI or not), Sec14 showed substantially increased rates of NBD-PC pick-up, whereas the PITPs were unaffected.	pi(4)p	47-53	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	110-115
30590084-10	2019	Our data demonstrates that ORP2 binds several phosphoinositides, both PI(4)P and multiply phosphorylated species.	pi(4)p	70-76	oxysterol binding protein like 2	Homo sapiens	27-31
30125555-10	2018	In conclusion, two-hit model of ethanol exposure disrupts NXN/DVL homeostatic status to allow DVL/FZD/PI4K2A complex formation and stimulates PI(4)P production.	pi(4)p	142-148	nucleoredoxin	Homo sapiens	58-61
29879417-1	2018	OSBP binds, extracts and transfers sterols and phosphatidylinositol-4-phosphate (PI(4)P between liposomes, but the sequence of steps at the membrane surface leading to ligand removal is poorly characterized.	pi(4)p	81-87	oxysterol binding protein	Homo sapiens	0-4
29879417-2	2018	In this study, we used dual polarization interferometry (DPI), a label-free surface analytical technique, to characterize the interaction of recombinant, purified OSBP as it flows over immobilized dioleoyl-phosphatidylcholine (DOPC) bilayers containing PI(4)P, cholesterol or 25-hydroxycholesterol.	pi(4)p	253-259	oxysterol binding protein	Homo sapiens	163-167
29879417-3	2018	Kinetics of membrane interaction were analyzed for PI(4)P-binding and phosphorylation mutants of OSBP.	pi(4)p	51-57	oxysterol binding protein	Homo sapiens	97-101
29879417-4	2018	Wild-type OSBP demonstrated a distinctive association with immobilized DOPC bilayers containing 1-8 mol% PI(4)P that was characterized by initial saturable binding followed by desorption, indicative of PI(4)P extraction.	pi(4)p	105-111	oxysterol binding protein	Homo sapiens	10-14
29879417-4	2018	Wild-type OSBP demonstrated a distinctive association with immobilized DOPC bilayers containing 1-8 mol% PI(4)P that was characterized by initial saturable binding followed by desorption, indicative of PI(4)P extraction.	pi(4)p	202-208	oxysterol binding protein	Homo sapiens	10-14
29879417-5	2018	In support of this conclusion, an OSBP mutant with impaired binding and extraction of PI(4)P was stably absorbed to PI(4)P-containing membranes, while a pleckstrin homology domain mutant did not associate with PI(4)P-containing membranes.	pi(4)p	86-92	oxysterol binding protein	Homo sapiens	34-38
29879417-5	2018	In support of this conclusion, an OSBP mutant with impaired binding and extraction of PI(4)P was stably absorbed to PI(4)P-containing membranes, while a pleckstrin homology domain mutant did not associate with PI(4)P-containing membranes.	pi(4)p	116-122	oxysterol binding protein	Homo sapiens	34-38
29879417-5	2018	In support of this conclusion, an OSBP mutant with impaired binding and extraction of PI(4)P was stably absorbed to PI(4)P-containing membranes, while a pleckstrin homology domain mutant did not associate with PI(4)P-containing membranes.	pi(4)p	116-122	oxysterol binding protein	Homo sapiens	34-38
29879417-8	2018	These real-time flow studies allow us to dissect the association of OSBP with PI(4)P into discrete components; initial recruitment to PI(4)P membranes by the PH domain, detection and extraction of PI(4)P, and desorption due to ligand depletion.	pi(4)p	78-84	oxysterol binding protein	Homo sapiens	68-72
30125555-10	2018	In conclusion, two-hit model of ethanol exposure disrupts NXN/DVL homeostatic status to allow DVL/FZD/PI4K2A complex formation and stimulates PI(4)P production.	pi(4)p	142-148	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	62-65
29217618-13	2018	Taken together the data indicate that LPS triggers S-palmitoylation and activation of PI4KIIbeta, which generates PI(4)P involved in signaling pathways controlling production of proinflammatory cytokines.	pi(4)p	114-120	toll-like receptor 4	Mus musculus	38-41
29930082-1	2018	Oxysterol binding protein (OSBP)-related protein 4L (ORP4L, also known as OSBPL2), a closely related paralogue and interacting partner of OSBP, binds sterols and phosphatidylinositol 4-phosphate [PI(4)P] and regulates cell proliferative signalling at the plasma membrane (PM).	pi(4)p	196-202	oxysterol binding protein like 2	Homo sapiens	74-80
29930082-1	2018	Oxysterol binding protein (OSBP)-related protein 4L (ORP4L, also known as OSBPL2), a closely related paralogue and interacting partner of OSBP, binds sterols and phosphatidylinositol 4-phosphate [PI(4)P] and regulates cell proliferative signalling at the plasma membrane (PM).	pi(4)p	196-202	oxysterol binding protein	Homo sapiens	27-31
29596003-0	2018	The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol.	pi(4)p	49-55	oxysterol binding protein	Homo sapiens	4-29
28196861-9	2017	Furthermore, we found a strong and specific binding preference of Naa60 toward membranes containing the phosphatidylinositol PI(4)P, thus possibly explaining the primary residency of Naa60 at the PI(4)P-rich Golgi.	pi(4)p	125-131	N-alpha-acetyltransferase 60, NatF catalytic subunit	Homo sapiens	66-71
28865956-3	2017	At 30 min after Tfn treatment, DRG2 localized to membrane tubules which were enriched with phosphatidylinositol 4-monophosphate [PI(4)P] and did not contain Rab5.	pi(4)p	129-135	developmentally regulated GTP binding protein 2	Homo sapiens	31-35
28720663-3	2017	Earlier work demonstrated that the endolysosomal lipid PI(3,5)P2 activates V-ATPases containing the vacuolar a-subunit isoform in Saccharomyces cerevisiae Here we demonstrate that PI(4)P, the predominant Golgi phosphatidylinositol (PI) species, directly interacts with the cytosolic amino terminal (NT) domain of the yeast Golgi V-ATPase a-isoform Stv1.	pi(4)p	180-186	H(+)-transporting V0 sector ATPase subunit a	Saccharomyces cerevisiae S288C	348-352
28720663-4	2017	Lysine-84 of Stv1NT is essential for interaction with PI(4)P in vitro and in vivo, and interaction with PI(4)P is required for efficient localization of Stv1-containing V-ATPases.	pi(4)p	54-60	H(+)-transporting V0 sector ATPase subunit a	Saccharomyces cerevisiae S288C	13-17
28196861-9	2017	Furthermore, we found a strong and specific binding preference of Naa60 toward membranes containing the phosphatidylinositol PI(4)P, thus possibly explaining the primary residency of Naa60 at the PI(4)P-rich Golgi.	pi(4)p	125-131	N-alpha-acetyltransferase 60, NatF catalytic subunit	Homo sapiens	183-188
27217553-6	2016	Further experiments using the rapamycin-recruitable phosphatase Sac1 to hydrolyze PI(4)P and the P4M probe to visualize PI(4)P suggested that PI(4)P levels increased after myo-inositol supplementation with SMIT1 expression.	pi(4)p	82-88	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	64-68
28319008-5	2017	We discovered that Osh1 ORD binds ergosterol and phosphatidylinositol 4-phosphate PI(4)P in a competitive manner, suggesting counter-transport function of the two lipids.	pi(4)p	82-88	oxysterol-binding protein related protein SWH1	Saccharomyces cerevisiae S288C	19-23
28319008-6	2017	Ergosterol is bound to the hydrophobic pocket in a head-down orientation, and the structure of the PI(4)P-binding site in Osh1 is well conserved.	pi(4)p	99-105	oxysterol-binding protein related protein SWH1	Saccharomyces cerevisiae S288C	122-126
28319008-7	2017	Our results suggest that Osh1 performs non-vesicular transport of ergosterol and PI(4)P at the NVJ.	pi(4)p	81-87	oxysterol-binding protein related protein SWH1	Saccharomyces cerevisiae S288C	25-29
27511903-5	2016	This process is driven by the disruption of PI(4)P-dependent anterograde trafficking from the Golgi, and it also exists in Atg5-deficient mammalian cells.	pi(4)p	44-50	autophagy related 5	Homo sapiens	123-127
25754030-5	2015	We conclude that PI(4,5)P2 and potentially its precursor PI(4)P are positive cofactors for TRPV1, acting via direct interaction with the channel, and their depletion by Ca(2+)-induced activation of phospholipase Cdelta isoforms (PLCdelta) limits channel activity during capsaicin-induced desensitization.	pi(4)p	57-63	transient receptor potential cation channel subfamily V member 1	Homo sapiens	91-96
26150791-11	2015	Thus, Kir6.2, a channel activated by PI(4,5)P2 and PI(4)P was insensitive to VSP.	pi(4)p	51-57	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	6-12
26305592-8	2015	Increasing ciliary PI(4,5)P2 levels or conferring the ability to bind PI(4)P on Tulp3 increases the ciliary localization of Tulp3.	pi(4)p	70-76	TUB like protein 3	Homo sapiens	80-85
26305592-8	2015	Increasing ciliary PI(4,5)P2 levels or conferring the ability to bind PI(4)P on Tulp3 increases the ciliary localization of Tulp3.	pi(4)p	70-76	TUB like protein 3	Homo sapiens	124-129
24843134-0	2014	Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current.	pi(4)p	35-41	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	101-106
24843134-8	2014	Recruiting the endoplasmic reticulum (ER) toward the Golgi membranes mimics the effects of depleting PI(4)P at the Golgi, apparently due to the trans actions of endogenous ER Sac1.	pi(4)p	101-107	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	175-179
25918361-2	2015	Here, we used the ability of the TRPV1 ion channel to discriminate between PI(4,5)P2 and PI(4)P to localize the region of TRPV1 sequence that interacts directly with the phosphoinositide.	pi(4)p	89-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	33-38
25918361-2	2015	Here, we used the ability of the TRPV1 ion channel to discriminate between PI(4,5)P2 and PI(4)P to localize the region of TRPV1 sequence that interacts directly with the phosphoinositide.	pi(4)p	89-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-127
25918361-5	2015	We used chemically induced and voltage-activated phosphatases to determine that PI(4)P continued to support TRPV1 activity even after depletion of PI(4,5)P2 from the plasma membrane.	pi(4)p	80-86	transient receptor potential cation channel subfamily V member 1	Homo sapiens	108-113
25918361-7	2015	Rather, conversion of a PI(4,5)P2-selective channel to a PI(4)P-selective channel indicates that a structured phosphoinositide-binding site mediates the regulation of TRPV1 activity and that the amino acid at position 721 likely interacts directly with the moiety at the 5" position of the phosphoinositide.	pi(4)p	57-63	transient receptor potential cation channel subfamily V member 1	Homo sapiens	167-172
25670203-2	2015	We found that activation of TRPV1 channels with capsaicin either in dorsal root ganglion neurons or in a heterologous expression system inhibited the mechanosensitive Piezo1 and Piezo2 channels by depleting phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and its precursor phosphatidylinositol 4-phosphate [PI(4)P] from the plasma membrane through Ca(2+)-induced phospholipase Cdelta (PLCdelta) activation.	pi(4)p	309-315	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-33
25670203-2	2015	We found that activation of TRPV1 channels with capsaicin either in dorsal root ganglion neurons or in a heterologous expression system inhibited the mechanosensitive Piezo1 and Piezo2 channels by depleting phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and its precursor phosphatidylinositol 4-phosphate [PI(4)P] from the plasma membrane through Ca(2+)-induced phospholipase Cdelta (PLCdelta) activation.	pi(4)p	309-315	piezo type mechanosensitive ion channel component 1	Homo sapiens	167-173
25670203-2	2015	We found that activation of TRPV1 channels with capsaicin either in dorsal root ganglion neurons or in a heterologous expression system inhibited the mechanosensitive Piezo1 and Piezo2 channels by depleting phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and its precursor phosphatidylinositol 4-phosphate [PI(4)P] from the plasma membrane through Ca(2+)-induced phospholipase Cdelta (PLCdelta) activation.	pi(4)p	309-315	piezo type mechanosensitive ion channel component 2	Homo sapiens	178-184
24843134-4	2014	Depleting PI(4)P at the PM with a recruitable 4-phosphatase (Sac1) results in a decrease of PI(4,5)P2 measured by electrical or optical indicators.	pi(4)p	10-16	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	61-65
24786584-11	2014	Mutations that abolish PI(4)P binding impair recruitment of GOLPH3 to both the Golgi and the cleavage furrow.	pi(4)p	23-29	sauron	Drosophila melanogaster	60-66
24786584-12	2014	Moreover telophase cells from mutants with defective GOLPH3-PI(4)P interaction fail to accumulate PI(4)P-and Rab11-associated secretory organelles at the cleavage site.	pi(4)p	60-66	sauron	Drosophila melanogaster	53-59
24786584-1	2014	The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein has been described as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi.	pi(4)p	119-125	sauron	Drosophila melanogaster	21-43
24786584-12	2014	Moreover telophase cells from mutants with defective GOLPH3-PI(4)P interaction fail to accumulate PI(4)P-and Rab11-associated secretory organelles at the cleavage site.	pi(4)p	60-66	Rab11	Drosophila melanogaster	109-114
24786584-1	2014	The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein has been described as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi.	pi(4)p	119-125	sauron	Drosophila melanogaster	45-51
24786584-10	2014	We demonstrate that the molecular mechanism underlying GOLPH3 function in cytokinesis is strictly dependent on the ability of this protein to interact with PI(4)P.	pi(4)p	156-162	sauron	Drosophila melanogaster	55-61
24206846-9	2013	Rescue experiments demonstrate requirements for PI4K2beta-AP-1 complex formation and PI4K2beta-mediated PI(4)P synthesis.	pi(4)p	104-110	phosphatidylinositol 4-kinase type 2 beta	Danio rerio	85-94
24314079-6	2013	In particular, we find that TRPV1 is more selective for PI(4,5)P2 than PI(4)P and activated by extremely low membrane mole fractions of PIPs.	pi(4)p	71-77	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-33
24209621-0	2013	A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP.	pi(4)p	28-34	oxysterol binding protein	Homo sapiens	100-104
24209621-0	2013	A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP.	pi(4)p	61-67	oxysterol binding protein	Homo sapiens	100-104
24209621-1	2013	Several proteins at endoplasmic reticulum (ER)-Golgi membrane contact sites contain a PH domain that interacts with the Golgi phosphoinositide PI(4)P, a FFAT motif that interacts with the ER protein VAP-A, and a lipid transfer domain.	pi(4)p	143-149	VAMP associated protein A	Homo sapiens	199-204
24209621-5	2013	Finally, PI(4)P is hydrolyzed in cis by the ER protein Sac1.	pi(4)p	9-15	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	55-59
24209621-8	2013	Thus, OSBP-mediated back transfer of PI(4)P might coordinate the transfer of other lipid species at the ER-Golgi interface.	pi(4)p	37-43	oxysterol binding protein	Homo sapiens	6-10
23552101-7	2013	PIP5K1B encodes phosphatidylinositol 4-phosphate 5-kinase beta type I (pip5k1beta), an enzyme functionally linked to actin cytoskeleton dynamics that phosphorylates phosphatidylinositol 4-phosphate [PI(4)P] to generate phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2].	pi(4)p	199-205	phosphatidylinositol-4-phosphate 5-kinase type 1 beta	Homo sapiens	0-7
23552101-7	2013	PIP5K1B encodes phosphatidylinositol 4-phosphate 5-kinase beta type I (pip5k1beta), an enzyme functionally linked to actin cytoskeleton dynamics that phosphorylates phosphatidylinositol 4-phosphate [PI(4)P] to generate phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2].	pi(4)p	199-205	phosphatidylinositol-4-phosphate 5-kinase type 1 alpha	Homo sapiens	71-81
23823324-2	2013	In this issue of Structure, Tong and colleagues find that the yeast OSBP homolog, Osh3, binds PI(4)P but not sterol, supporting the view that PI(4)P regulation, not sterol transport, is the key activity for OSBP homologs.	pi(4)p	94-100	oxysterol-binding protein related protein OSH3	Saccharomyces cerevisiae S288C	82-86
23823324-2	2013	In this issue of Structure, Tong and colleagues find that the yeast OSBP homolog, Osh3, binds PI(4)P but not sterol, supporting the view that PI(4)P regulation, not sterol transport, is the key activity for OSBP homologs.	pi(4)p	142-148	oxysterol-binding protein related protein OSH3	Saccharomyces cerevisiae S288C	82-86
21851817-4	2011	In this report, we find that phosphatidylinositol 4-kinase IIIbeta (PI4KIIIbeta), a lipid kinase that phosphorylates phosphatidylinositol (PI) to PI(4)P, disrupts in vitro mammary acinar formation.	pi(4)p	146-152	phosphatidylinositol 4-kinase beta	Homo sapiens	68-79
21851817-7	2011	Ectopic expression of PI4KIIIbeta or eEF1A2 alters the localization of PI(4)P and PI(4,5)P(2) within acini, indicating the importance of these lipids in acinar development.	pi(4)p	71-77	phosphatidylinositol 4-kinase beta	Homo sapiens	22-33
21851817-7	2011	Ectopic expression of PI4KIIIbeta or eEF1A2 alters the localization of PI(4)P and PI(4,5)P(2) within acini, indicating the importance of these lipids in acinar development.	pi(4)p	71-77	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	37-43
20921230-5	2010	Activation of Kir2.1 by phosphatidylinositol phosphates is also highly selective for PIP(2); PI, PI(4)P, and PI(5)P do not activate channels, and PI(3,4,5)P(3) causes minimal activity.	pi(4)p	97-103	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	14-20
23843517-6	2013	Maximal pharmacological TRPV1 stimulation led to a robust decrease of both PI(4,5)P2 and its precursor PI(4)P in sensory neurons.	pi(4)p	103-109	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	24-29
23843517-7	2013	Attenuating the decrease of either lipid significantly reduced desensitization, and simultaneous reduction of PI(4,5)P2 and PI(4)P independently of PLC inhibited TRPV1.	pi(4)p	124-130	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	162-167
23791945-4	2013	Osh3 recognizes PI(4)P by the highly conserved residues in the tunnel of ORD whereas it lacks sterol binding due to the narrow hydrophobic tunnel.	pi(4)p	16-22	oxysterol-binding protein related protein OSH3	Saccharomyces cerevisiae S288C	0-4
22404177-9	2012	All the PI(3)P-, PI(4)P- and PI(5)P-containing molecules tested induced TRPC1/C5/C6 channel activation, whereas only PI(3)P stimulated TRPC3/C7 channels.	pi(4)p	17-23	short transient receptor potential channel 1	Oryctolagus cuniculus	72-77
22404177-9	2012	All the PI(3)P-, PI(4)P- and PI(5)P-containing molecules tested induced TRPC1/C5/C6 channel activation, whereas only PI(3)P stimulated TRPC3/C7 channels.	pi(4)p	17-23	complement C5	Oryctolagus cuniculus	78-83
22289921-5	2012	The pleckstrin homology domain of wt ITK binds most prominently to phosphatidylinositol monophosphates (PI(3)P, PI(4)P, PI(5)P) and to lesser extend to its double or triple phosphorylated derivates (PIP2, PIP3), interactions which were dramatically reduced in the patient with the ITK(R29H) mutant.	pi(4)p	112-118	IL2 inducible T cell kinase	Homo sapiens	37-40