PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2534127-6	1989	From the results of the lectin-binding to these glycoproteins after sialidase treatment, CD45 antigens and leukosialin molecules on lpr T cells were found to have many more terminal alpha 2,3-linked sialic acids than those on +/+ T cells, and this fact explains why lpr T cells have more binding sites for PHA-E4 but fewer binding sites for RCA.	Sialic Acids	199-211	protein tyrosine phosphatase, receptor type, C	Mus musculus	89-93
2534127-6	1989	From the results of the lectin-binding to these glycoproteins after sialidase treatment, CD45 antigens and leukosialin molecules on lpr T cells were found to have many more terminal alpha 2,3-linked sialic acids than those on +/+ T cells, and this fact explains why lpr T cells have more binding sites for PHA-E4 but fewer binding sites for RCA.	Sialic Acids	199-211	sialophorin	Mus musculus	107-118
2534127-6	1989	From the results of the lectin-binding to these glycoproteins after sialidase treatment, CD45 antigens and leukosialin molecules on lpr T cells were found to have many more terminal alpha 2,3-linked sialic acids than those on +/+ T cells, and this fact explains why lpr T cells have more binding sites for PHA-E4 but fewer binding sites for RCA.	Sialic Acids	199-211	Fas (TNF receptor superfamily member 6)	Mus musculus	132-135
2633047-9	1989	Cleavage of terminal sialic acids from native C9 by neuraminidase results in an Mr 67,000 product with nearly unaltered hemolytic activity.	Sialic Acids	21-33	neuraminidase 1	Homo sapiens	52-65
2472199-10	1989	Periodate oxidation abolished reactivity of the antibodies to GD3 but not that to O-AcGD3, revealing that the glycerol side chain of the sialic acids in both GD3s was an important structure of the epitope.	Sialic Acids	137-149	GRDX	Homo sapiens	62-65
2808392-4	1989	Bovine and equine submaxillary mucins that contain 9(7,8)-O-acetyl and 4-O-acetylsialic acids were potent inhibitors in contrast to the non-acetylated sialic acids of ovine submaxillary mucin.	Sialic Acids	81-93	mucin 1, cell surface associated	Bos taurus	31-36
2476488-8	1989	Thus, these results demonstrate that the Ag determinants recognized by the UCHL1 and the anti-220/205/190-kDa mAb, which are topographically unrelated, are associated with sialic acids from O-linked-type oligosaccharides, emphasizing the contribution of carbohydrates to the Ag heterogeneity of CD45 molecular complex.	Sialic Acids	172-184	ubiquitin C-terminal hydrolase L1	Homo sapiens	75-80
2476488-8	1989	Thus, these results demonstrate that the Ag determinants recognized by the UCHL1 and the anti-220/205/190-kDa mAb, which are topographically unrelated, are associated with sialic acids from O-linked-type oligosaccharides, emphasizing the contribution of carbohydrates to the Ag heterogeneity of CD45 molecular complex.	Sialic Acids	172-184	protein tyrosine phosphatase receptor type C	Homo sapiens	295-299
2472199-10	1989	Periodate oxidation abolished reactivity of the antibodies to GD3 but not that to O-AcGD3, revealing that the glycerol side chain of the sialic acids in both GD3s was an important structure of the epitope.	Sialic Acids	137-149	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	158-162
2562505-1	1989	Periodate oxidation of terminal N-acetyl- and N-glycoloylneuraminic acid residues in the mucins from edible bird nest substance and pig submandibular gland, respectively, can be carried out under conditions which exclusively give rise to the formation of the C-7 analogues of these sialic acids.	Sialic Acids	282-294	complement C7	Sus scrofa	259-262
2470764-9	1989	The one unique feature of the carbohydrate groups of equine and guinea pig alpha 2-macroglobulins was the presence of 4-O-Ac-Neu5Ac as 30-50% of the total sialic acids, while human alpha 2-macroglobulin contained only Neu 5Ac.	Sialic Acids	155-167	alpha-2-macroglobulin	Homo sapiens	75-96
2470765-7	1989	These 4-O-acetylated sialic acids have been found in few species, making their coincidence with high inhibitory potency in equine and guinea pig alpha 2-macroglobulin striking.	Sialic Acids	21-33	alpha-2-macroglobulin	Homo sapiens	145-166
2765299-3	1989	After treatment with neuraminidase 2.92 nmol/mg dry weight and 3.73 nmol/mg dry weight of sialic acid were freed from U 251 cells and C6 cell, but only 8.11% (U 251 cell) and 11.24% (C 6 cell) of these sialic acids originated from glycolipid, and thus the major part of sialic acid might be released from glycoprotein of the cells.	Sialic Acids	202-214	neuraminidase 2	Homo sapiens	21-36
2535773-4	1989	The nature of the intraindividual biochemical variation can be explained by differences in sialic acid content because after digestion with neuraminidase the terminal sialic acids are removed to yield a single major band corresponding to the C1R polypeptide.	Sialic Acids	167-179	complement C1r	Homo sapiens	242-245
2906937-2	1988	Following removal of sialic acids with the exoglycosidase, neuraminidase, [125I]N-azidophenethylspiperone photoincorporated into a protein of Mr = 54,000 with the appropriate pharmacological profile for D2 receptors.	Sialic Acids	21-33	neuraminidase 1	Homo sapiens	59-72
2487679-6	1989	It was concluded that two types of N-linked oligosaccharides as well as sialic acids mediate at least in part the tissue type-specific membrane activity for Thy-1 alloantibody response.	Sialic Acids	72-84	Thy-1 cell surface antigen	Homo sapiens	157-162
3219349-10	1988	Enzymatic deglycosylation of the 18-21-kDa TGF alpha species by sequential removal of sialic acids and O- and N-linked carbohydrate reduced the molecular weight to 11K.	Sialic Acids	86-98	transforming growth factor alpha	Rattus norvegicus	43-52
3225199-2	1988	Identification of neuraminidase-sensitive and neuraminidase-resistant sialic acids and their side chain O-acyl variants.	Sialic Acids	70-82	neuraminidase 1	Homo sapiens	18-31
3225199-2	1988	Identification of neuraminidase-sensitive and neuraminidase-resistant sialic acids and their side chain O-acyl variants.	Sialic Acids	70-82	neuraminidase 1	Homo sapiens	46-59
3217921-0	1988	The effect of enzymatic removal of sialic acids on the functional properties of protein C.	Sialic Acids	35-47	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	80-89
3779103-5	1986	These results indicate that differences in peripheral, neuraminidase-accessible sialic acids are important determinants of the gel electrophoretic mobility of the SMGs of the HL-60 line and sublines but are not likely related to the differentiation-resistance mechanism.	Sialic Acids	80-92	neuraminidase 1	Homo sapiens	55-68
2456204-3	1988	The pI of SP-hCG is 10.0, suggesting deficiency of sialic acids.	Sialic Acids	51-63	chorionic gonadotropin subunit beta 5	Homo sapiens	13-16
3630016-2	1987	When the glycomacropeptide was used as a substrate of neuraminidase, it exhibited many advantages as compared with ovomucin (high molecular substrate of the enzyme) due to increased content of sialic acids in the glycomacropeptide composition and to high solubility.	Sialic Acids	193-205	neuraminidase 1	Homo sapiens	54-67
2847818-5	1988	It was demonstrated that the specific binding of CP to erythrocyte receptors is determined by its interaction with two structural sites of the carbohydrate moiety of the CP molecule, i.e., the terminal residues of sialic acids and a site, (formula; see text) located at a large distance from the chain terminus.	Sialic Acids	214-226	ceruloplasmin	Homo sapiens	49-51
2847818-5	1988	It was demonstrated that the specific binding of CP to erythrocyte receptors is determined by its interaction with two structural sites of the carbohydrate moiety of the CP molecule, i.e., the terminal residues of sialic acids and a site, (formula; see text) located at a large distance from the chain terminus.	Sialic Acids	214-226	ceruloplasmin	Homo sapiens	170-172
3165384-4	1988	Incubation of liver endothelium with double-labeled TF (sialic acids with 3H and protein core with 125I or 59Fe) led initially to a concordant uptake of the two labels, which were then dissociated and 3H was retained by the cell.	Sialic Acids	56-68	transferrin	Rattus norvegicus	52-54
3711146-3	1986	Adhesion is mediated by a carbohydrate-binding protein and can be inhibited by N-acetylneuraminic acid or mucin, a glycoprotein with high sialic acids content.	Sialic Acids	138-150	solute carrier family 13 member 2	Rattus norvegicus	106-111
3780977-3	1986	The fact that calmodulin decreased the specific activity of UDP-N-acetyl-D-glucosamine 2"-epimerase, a key regulatory enzyme in the biosynthesis of glycoprotein sialic acids, and that trifluoperazine prevented the desialylation indicates that the membrane desialylation is a calmodulin-dependent process.	Sialic Acids	161-173	calmodulin 1	Homo sapiens	14-24
3800894-7	1986	The gel patterns showing higher-molecular-mass components are obtained when terminal sialic acid addition is prevented by the incubation of lung tissue with monensin or when terminal sialic acids are digested from the fully processed protein with neuraminidase.	Sialic Acids	183-195	neuraminidase 1	Homo sapiens	247-260
3711146-5	1986	Experiments to block adhesion by pretreatment of cells with either neuraminidase or mucin show that the sialic acids-rich moiety is on the nerve cells, while its receptor is on the muscle fibers.	Sialic Acids	104-116	solute carrier family 13 member 2	Rattus norvegicus	84-89
2427759-6	1986	Periodic acid and neuraminidase treatments on tissue sections suggested that the chemical nature of the antigenic determinant of YH206 antigen was carbohydrate in nature which might be masked by sialic acids.	Sialic Acids	195-207	neuraminidase 1	Homo sapiens	18-31
6698805-4	1984	The sialic acids of the crude glycoproteins isolated from normal ileum were significantly less neuraminidase-susceptible and more C4 substituted (P less than 0.01) than those of the glycoproteins isolated either from normal upper small intestine (duodenum and jejunum) or from cases of Crohn"s disease of the ileum.	Sialic Acids	4-16	neuraminidase 1	Homo sapiens	95-108
3861610-7	1985	The lentil lectin-reactive glycophorin A molecules increased to Mr = 39,000 during chase and obtained sialic acids after 9 min of chase reflecting terminal N- and O-glycosylation.	Sialic Acids	102-114	glycophorin A (MNS blood group)	Homo sapiens	27-40
3893431-0	1985	Removal of sialic acids from the purified insulin receptor results in enhanced insulin-binding and kinase activities.	Sialic Acids	11-23	insulin receptor	Homo sapiens	42-58
3893431-0	1985	Removal of sialic acids from the purified insulin receptor results in enhanced insulin-binding and kinase activities.	Sialic Acids	11-23	insulin	Homo sapiens	42-49
4033233-6	1985	Treatment of young RBC with neuraminidase, which resulted in reduction of membrane-bound sialic acids to an extent similar to that of physiologically aged RBC, resulted in the concomitant exposure of PNA binding sites and in the agglutination of these cells by autologous serum.	Sialic Acids	89-101	neuraminidase 1	Homo sapiens	28-41
3936778-1	1985	The contribution of sialic acids and of N-linked sugars to the biological activity of the receptor for IL 2 has been evaluated by treating activated cells with Neuraminidase or by growing them in the presence of inhibitors of N-linked glycosylation or processing.	Sialic Acids	20-32	interleukin 2	Mus musculus	103-107
4063159-1	1985	Sialic acids present on luminal surfaces of vascular endothelium were determined by perfusing neuraminidase free of proteolytic activity through carotid arteries, iliac arteries and jugular veins of anaesthetized rabbits and guinea-pigs and through human umbilical veins.	Sialic Acids	0-12	neuraminidase 1	Homo sapiens	94-107
4063159-2	1985	Total sialic acids released in I h from arteries and veins, determined fluorimetrically, were 24-51 X 10(6) molecules/micron 2 endothelial surface; this was more, by up to two orders of magnitude, than sialic acids releasable by neuraminidase from other types of cells, i.e. from 0.15 X 10(6) for human erythrocytes to 15 X 10(6) for human platelets.	Sialic Acids	6-18	neuraminidase 1	Homo sapiens	229-242
6203875-0	1984	Histochemical identification of side chain substituted O-acylated sialic acids: the PAT-KOH-Bh-PAS and the PAPT-KOH-Bh-PAS procedures.	Sialic Acids	66-78	poly(A) polymerase beta	Homo sapiens	107-111
6698805-7	1984	The fractions differed significantly from one another with respect to the neuraminidase susceptibility of their sialic acids (P less than 0.01), the percentage of C4 (P less than 0.01) and side-chain substituted sialic acids (P less than 0.05), and the molar fucose-sialic acid ratio (P less than 0.05).	Sialic Acids	112-124	neuraminidase 1	Homo sapiens	74-87
6841529-0	1983	Analysis of sialic acids by gas chromatography of the mannosamine derivatives released by the action of N-acetylneuraminate lyase.	Sialic Acids	12-24	N-acetylneuraminate pyruvate lyase	Homo sapiens	104-129
6630194-0	1983	A neuraminidase from Streptococcus sanguis that can release O-acetylated sialic acids.	Sialic Acids	73-85	neuraminidase 1	Homo sapiens	2-15
6680308-3	1983	It was demonstrated that enzymatic removal of some thyroglobulin sialic acids results in increasing its resistance to proteolysis.	Sialic Acids	65-77	thyroglobulin	Homo sapiens	51-64
6680308-4	1983	Apparently, sialic acids are essential for maintaining an optimal thyroglobulin conformation for the action of proteases at hormonal biosynthesis from the reserve form.	Sialic Acids	12-24	thyroglobulin	Homo sapiens	66-79
6300382-1	1983	Bound sialic acids on rat spermatozoa were assayed by oxidation with 1 mM-NaIO4 at 0 degree C, liberating C-9 as formaldehyde which was further quantitated using 3-methyl-2-benzothiazolinone.	Sialic Acids	6-18	complement C9	Rattus norvegicus	106-109
6425424-4	1984	These results suggest that the heterogeneity of IFN-gamma induced in our system was the result of the difference in the content of sialic acids.	Sialic Acids	131-143	interferon gamma	Homo sapiens	48-57
6841529-1	1983	A convenient method for the analysis of sialic acids is proposed, which is based on their dissociation into pyruvate and N-acylmannosamines by the action of N-acetylneuraminate lyase, followed by gas-chromatographic analysis of the latter products as trimethylsilylated diethyl dithioacetals.	Sialic Acids	40-52	N-acetylneuraminate pyruvate lyase	Homo sapiens	157-182
6841529-2	1983	Conjugated sialic acids should be freed with neuraminidase before being subjected to the action of the lyase, but these sequential enzymic reactions may be performed in one pot.	Sialic Acids	11-23	neuraminidase 1	Homo sapiens	45-58
7060593-5	1982	After denaturation with sodium dodecyl sulfate, Vibrio cholerae neuraminidase also liberated the N-acetylgalactosamine-bound sialic acids.	Sialic Acids	125-137	neuraminidase 1	Homo sapiens	64-77
7085659-2	1982	The labeling procedure cleaves the sialic acids to a neuraminidase-sensitive 7-carbon derivative, 5-acetamido-3,5-dideoxy-L-arabino-heptulosonic acid, termed AcNeu7 (Van Lenten, L., and Ashwell, G. (1971) J. Biol.	Sialic Acids	35-47	neuraminidase 1	Homo sapiens	53-66
7060593-7	1982	The results show that distal sialic acids linked to galactose are readily available to neuraminidase, and that their negative charge gives an increased electrophoretic mobility in polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate.	Sialic Acids	29-41	neuraminidase 1	Homo sapiens	87-100
7060593-8	1982	In contrast, most of the N-acetylgalactosamine-linked sialic acids of glycophorin A are not liberated by neuraminidase without denaturation of the substrate.	Sialic Acids	54-66	glycophorin A (MNS blood group)	Homo sapiens	70-83
7150713-5	1982	Aggregation can be inhibited by addition of human serum albumin and neuraminidase treatment (removal of sialic acids).	Sialic Acids	104-116	neuraminidase 1	Homo sapiens	68-81
6168144-0	1981	[Effect of the sialic acids of mucin on its ability to increase the virulence of serotype A meningococci].	Sialic Acids	15-27	LOC100508689	Homo sapiens	31-36
6168144-1	1981	The influence of the content of bound sialic acids in mucin on its capacity to decrease the infective dose of meningococcal culture has been studied; as a result, the direct relationship with a high degree of correlation between these two characteristics has been revealed.	Sialic Acids	38-50	LOC100508689	Homo sapiens	54-59
6168144-2	1981	The direct relationship between the content of bound sialic acids and the viscosity of aqueous mucin solutions has also been revealed in this study.	Sialic Acids	53-65	LOC100508689	Homo sapiens	95-100
6168144-3	1981	The above-mentioned biological activity of mucin is not observed in the presence of free sialic acids.	Sialic Acids	89-101	LOC100508689	Homo sapiens	43-48
7354217-3	1980	Chemical analysis of the normal glycoproteins indicated that the great majority of the sialic acids were resistant to digestion with Vibrio cholerae neuraminidase, presumably due to an ester substituent at C4.	Sialic Acids	87-99	neuraminidase 1	Homo sapiens	149-162
6168157-1	1981	The demonstration of 0-acylated sialic acids in the mucin of cancer metastases by Culling"s periodic acid-borohydride-potassium hydroxide-periodic acid-Schiff method (PB/KOH/PAS) is helpful in distinguishing between mucin-producing primary colorectal adenocarcinoma (which will be in 60 to 70% positive) and mucin-producing primary lung adenocarcinoma (which will be negative).	Sialic Acids	32-44	LOC100508689	Homo sapiens	52-57
6168157-2	1981	In addition to colorectal mucin, the 0-acylated sialic acids may be demonstrated in the mucin of some gastric and gallbladder carcinomas, and only exceptionally in pancreatic, ovarian, and prostatic cancers.	Sialic Acids	48-60	LOC100508689	Homo sapiens	88-93
6255459-3	1980	By either criterion, treatment of the cells with Vibrio cholerae neuraminidase to remove cell surface sialic acids rendered them resistant to infection by Sendai virus.	Sialic Acids	102-114	neuraminidase 1	Homo sapiens	65-78
7354217-4	1980	The sialic acids of the tumor glycoproteins were significantly different from normal, in that they were less resistant to digestion with neuraminidase (p greater than 0.01), and therefore had a lower percentage of substitution at C4 (p greater than 0.01).	Sialic Acids	4-16	neuraminidase 1	Homo sapiens	137-150
6153110-5	1980	Removal of sialic acids with neuraminidase or inhibition of glycosylation with tunicamycin reduced the microheterogeneity of both DR subunits.	Sialic Acids	11-23	neuraminidase 1	Homo sapiens	29-42
928327-1	1977	In studying the formation of insulin complexes with transferrin the role played by sialic acids in this process was ascertained.	Sialic Acids	83-95	insulin	Homo sapiens	29-36
291010-7	1979	These results suggest that specific gangliosides or related sialic acid-containing glycoconjugates on the cell surface may act as the receptors for fibronectin.	Sialic Acids	60-71	fibronectin 1	Bos taurus	148-159
292622-5	1979	Neuraminidase experiments indicate the presence of sialic acid in the anodal component of the double-band pattern.	Sialic Acids	51-62	neuraminidase 1	Pan troglodytes	0-13
744535-2	1978	showed the possibility of using KOH/PAS effect (visualisation of C7 and C8O-acylated sialic acids characteristic to colon mucin) for differential diagnosis of metastatic colorectal cancer.	Sialic Acids	85-97	LOC100508689	Homo sapiens	122-127
39290-1	1979	Frog sartorius muscle fibres were incubated with the enzyme neuraminidase which is known to remove surface-bound sialic acids.	Sialic Acids	113-125	neuraminidase 1	Homo sapiens	60-73
304362-5	1978	6.7 residues/mol of galactose and 7.1 residues/mol of sialic acid which is essentially the same as the carbohydrate composition of the M-type alpha-1-antitrypsin.	Sialic Acids	54-65	serpin family A member 1	Homo sapiens	142-161
928327-0	1977	[Study of the role of sialic acids in the formation of bound form of insulin].	Sialic Acids	22-34	insulin	Homo sapiens	69-76
928327-1	1977	In studying the formation of insulin complexes with transferrin the role played by sialic acids in this process was ascertained.	Sialic Acids	83-95	transferrin	Homo sapiens	52-63
928327-3	1977	To study the role played by sialic acids of transferrin molecule in the formation of complexes with insulin the author used transferrin untreated and treated with neuraminidase, an enzyme splitting the sialic acid molecules from grycoprotein specifically.	Sialic Acids	28-40	transferrin	Homo sapiens	44-55
928327-3	1977	To study the role played by sialic acids of transferrin molecule in the formation of complexes with insulin the author used transferrin untreated and treated with neuraminidase, an enzyme splitting the sialic acid molecules from grycoprotein specifically.	Sialic Acids	28-40	insulin	Homo sapiens	100-107
928327-3	1977	To study the role played by sialic acids of transferrin molecule in the formation of complexes with insulin the author used transferrin untreated and treated with neuraminidase, an enzyme splitting the sialic acid molecules from grycoprotein specifically.	Sialic Acids	28-40	neuraminidase 1	Homo sapiens	163-176
33340149-3	2021	Cell surface sialic acids are sensed by complement factor H (FH) to inhibit complement activation or by sialic acid-binding immunoglobulin-like lectin (SIGLEC) receptors to inhibit microglial activation, phagocytosis, and oxidative burst.	Sialic Acids	13-25	complement factor H	Homo sapiens	51-59
985458-0	1976	Increase in sialic acids removable by neuraminidase during the shape change of platelets.	Sialic Acids	12-24	neuraminidase 1	Homo sapiens	38-51
985458-2	1976	The shape change associated with activation gave rise to an increase in sialic acids removable by neuraminidase.	Sialic Acids	72-84	neuraminidase 1	Homo sapiens	98-111
4850957-4	1974	Transitional mucosa showed increased levels of total hexosamines and sialic acid as compared with the normal and this was accompanied by an increase in neuraminidase-sensitive sialic acids.	Sialic Acids	176-188	neuraminidase 1	Homo sapiens	152-165
4705641-1	1973	The role of the surface charge of human red blood cells (RBC"s) in affecting RBC aggregation by macromolecules was studied by comparing the behavior of normal RBC"s with that of RBC"s treated with neuraminidase, which removes the sialic acids from the cell membrane and reduces the zeta potential.	Sialic Acids	230-242	neuraminidase 1	Homo sapiens	197-210
1245486-8	1976	The first group of proteins contains sialic acids linked to the penultimate galactosyl/N-acetylgalactosaminyl residues, which are efficiently labeled only after pretreatment with neuraminidase.	Sialic Acids	37-49	neuraminidase 1	Homo sapiens	179-192
1183043-3	1975	After digestion with neuraminidase, the enzyme was shown to interact with ricin, and a good correlation was found between the amount of liberated sialic acids and the extent of agglutination.	Sialic Acids	146-158	neuraminidase 1	Bos taurus	21-34
33872695-9	2021	Further, the surface level of alpha2,3-linked sialic acids was negatively correlated with the sensitivity of AML cell lines to MEK/ERK inhibitors.	Sialic Acids	46-58	immunoglobulin kappa variable 2-24	Homo sapiens	30-38
33872695-9	2021	Further, the surface level of alpha2,3-linked sialic acids was negatively correlated with the sensitivity of AML cell lines to MEK/ERK inhibitors.	Sialic Acids	46-58	mitogen-activated protein kinase kinase 7	Homo sapiens	127-130
33872695-9	2021	Further, the surface level of alpha2,3-linked sialic acids was negatively correlated with the sensitivity of AML cell lines to MEK/ERK inhibitors.	Sialic Acids	46-58	mitogen-activated protein kinase 1	Homo sapiens	131-134
33340149-3	2021	Cell surface sialic acids are sensed by complement factor H (FH) to inhibit complement activation or by sialic acid-binding immunoglobulin-like lectin (SIGLEC) receptors to inhibit microglial activation, phagocytosis, and oxidative burst.	Sialic Acids	13-25	complement factor H	Homo sapiens	61-63
33983135-8	2021	Knock-down of Sdhb and Vhl in an in vitro model demonstrated that inositol metabolism and sialic acids were similarly modulated as in tumors of the respective cluster.	Sialic Acids	90-102	succinate dehydrogenase complex iron sulfur subunit B	Rattus norvegicus	14-18
33788378-8	2021	The sialic acids on UMOD, local pH and sodium concentration could impact the binding capacity between UMOD and cFH and thus regulate the activation of complement AP.	Sialic Acids	4-16	uromodulin	Homo sapiens	20-24
33788378-8	2021	The sialic acids on UMOD, local pH and sodium concentration could impact the binding capacity between UMOD and cFH and thus regulate the activation of complement AP.	Sialic Acids	4-16	uromodulin	Homo sapiens	102-106
33788378-8	2021	The sialic acids on UMOD, local pH and sodium concentration could impact the binding capacity between UMOD and cFH and thus regulate the activation of complement AP.	Sialic Acids	4-16	complement factor H	Homo sapiens	111-114
33320370-2	2021	The pathogenicity of IgG, i.e. the ability to elicit stimulatory effects via FcgammaRs, can be modulated by attachment of sugar moieties, including sialic acids.	Sialic Acids	148-160	immunoglobulin heavy variable V1-62	Mus musculus	21-24
33320370-6	2021	Using cell cultures of murine osteoclasts, we show that IgG complexes without sialic acids (de-IgG complexes) enhance receptor activator of nuclear factor kappa-Beta ligand (RANKL)-stimulated osteoclastogenesis, an effect associated with increased FcgammaRIII expression.	Sialic Acids	78-90	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	174-179
33909065-6	2021	However, recent in vitro and ex vivo studies of sialic acids on ACE2 receptor confirmed an opposite role for SARS-CoV-2 binding.	Sialic Acids	48-60	angiotensin converting enzyme 2	Homo sapiens	64-68
33909065-8	2021	Further, the ACE2 glycosylation mutants indicate that sialic acids on ACE2 receptor prevent ACE2-spike protein interaction.	Sialic Acids	54-66	angiotensin converting enzyme 2	Homo sapiens	13-17
33909065-8	2021	Further, the ACE2 glycosylation mutants indicate that sialic acids on ACE2 receptor prevent ACE2-spike protein interaction.	Sialic Acids	54-66	angiotensin converting enzyme 2	Homo sapiens	70-74
33909065-8	2021	Further, the ACE2 glycosylation mutants indicate that sialic acids on ACE2 receptor prevent ACE2-spike protein interaction.	Sialic Acids	54-66	angiotensin converting enzyme 2	Homo sapiens	70-74
33909065-8	2021	Further, the ACE2 glycosylation mutants indicate that sialic acids on ACE2 receptor prevent ACE2-spike protein interaction.	Sialic Acids	54-66	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	97-102
33862336-5	2021	Furthermore, these cells expressed both alpha-2,3- and alpha-2,6-linked sialic acids with alpha-2,3 linkage being more abundant.	Sialic Acids	72-84	glycoprotein hormone subunit alpha 2	Homo sapiens	55-62
33758080-5	2021	In contrast, the disruption of O-glycosylation on the N-terminal Thr/Ser residues or the removal of alpha2,3-linked sialic acids from O-glycans enhanced the GPR15L binding.	Sialic Acids	116-128	G protein-coupled receptor 15	Homo sapiens	157-162
33862336-5	2021	Furthermore, these cells expressed both alpha-2,3- and alpha-2,6-linked sialic acids with alpha-2,3 linkage being more abundant.	Sialic Acids	72-84	glycoprotein hormone subunit alpha 2	Homo sapiens	55-62
33459939-1	2021	Sialic acids occur ubiquitously throughout vertebrate glycomes and often endcap glycans in either alpha2,3- or alpha2,6-linkage with diverse biological roles.	Sialic Acids	0-12	immunoglobulin kappa variable 2-24	Homo sapiens	98-107
33752328-2	2021	Changes of alpha-2,3-linked sialic acids in sialylated N-glycans are especially important in monitoring the initiation and progression of diseases.	Sialic Acids	28-40	glycoprotein hormone subunit alpha 2	Homo sapiens	11-18
33420022-4	2021	Next, we show that sialic acids present on ACE2 prevent efficient spike/ACE2-interaction.	Sialic Acids	19-31	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	66-71
33651882-4	2021	In contrast with FH, FHR-1 lacks the capacity to bind sialic acids, which prevents C3b-binding competition between FH and FHR-1 in host cell surfaces.	Sialic Acids	54-66	complement factor H related 1	Homo sapiens	21-26
33651882-4	2021	In contrast with FH, FHR-1 lacks the capacity to bind sialic acids, which prevents C3b-binding competition between FH and FHR-1 in host cell surfaces.	Sialic Acids	54-66	endogenous retrovirus group K member 3	Homo sapiens	83-86
33651882-4	2021	In contrast with FH, FHR-1 lacks the capacity to bind sialic acids, which prevents C3b-binding competition between FH and FHR-1 in host cell surfaces.	Sialic Acids	54-66	complement factor H	Homo sapiens	21-23
33651882-4	2021	In contrast with FH, FHR-1 lacks the capacity to bind sialic acids, which prevents C3b-binding competition between FH and FHR-1 in host cell surfaces.	Sialic Acids	54-66	complement factor H related 1	Homo sapiens	122-127
33651882-5	2021	aHUS-associated FHR-1 mutants are pathogenic because they have acquired the capacity to bind sialic acids, which increases FHR-1 avidity for surface-bound C3-activated fragments and results in C3b-binding competition with FH.	Sialic Acids	93-105	complement factor H related 1	Homo sapiens	16-21
33651882-5	2021	aHUS-associated FHR-1 mutants are pathogenic because they have acquired the capacity to bind sialic acids, which increases FHR-1 avidity for surface-bound C3-activated fragments and results in C3b-binding competition with FH.	Sialic Acids	93-105	complement factor H related 1	Homo sapiens	123-128
33651882-5	2021	aHUS-associated FHR-1 mutants are pathogenic because they have acquired the capacity to bind sialic acids, which increases FHR-1 avidity for surface-bound C3-activated fragments and results in C3b-binding competition with FH.	Sialic Acids	93-105	endogenous retrovirus group K member 3	Homo sapiens	193-196
33651882-5	2021	aHUS-associated FHR-1 mutants are pathogenic because they have acquired the capacity to bind sialic acids, which increases FHR-1 avidity for surface-bound C3-activated fragments and results in C3b-binding competition with FH.	Sialic Acids	93-105	complement factor H	Homo sapiens	16-18
33732239-9	2021	In contrast, the two amino acids substantially affected the binding of FH and FHR-1 to alpha2,3-linked sialic acids as host surfaces markers, with the S-to-L substitution causing an almost complete loss of recognition.	Sialic Acids	103-115	complement factor H related 1	Homo sapiens	78-83
33732239-9	2021	In contrast, the two amino acids substantially affected the binding of FH and FHR-1 to alpha2,3-linked sialic acids as host surfaces markers, with the S-to-L substitution causing an almost complete loss of recognition.	Sialic Acids	103-115	immunoglobulin kappa variable 2-24	Homo sapiens	87-95
33655075-0	2021	Correction to "The SARS-COV-2 Spike Protein Binds Sialic Acids, and Enables Rapid Detection in a Lateral Flow Point of Care Diagnostic Device".	Sialic Acids	50-62	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	30-35
33130090-6	2021	The reelin glycoprotein was found to carry the beta-N-Acetylglucosamine, alpha-Mannose, beta-Galactose, and alpha-2,3 and alpha2,6 linked sialic acids by lectin blotting.	Sialic Acids	138-150	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	122-130
33526785-3	2021	OC is accompanied by low expression of cytosolic sialidase (Neu2) and ~10-fold more alpha2,6- than alpha2,3-linked sialic acids found through qPCR, western blot, and flow cytometry.	Sialic Acids	115-127	immunoglobulin kappa variable 2-24	Homo sapiens	99-107
33526785-4	2021	Interestingly, Neu2 overexpression cleaved alpha2,6- and alpha2,3-linked sialic acids and reduced cell viability.	Sialic Acids	73-85	neuraminidase 2	Homo sapiens	15-19
33526785-4	2021	Interestingly, Neu2 overexpression cleaved alpha2,6- and alpha2,3-linked sialic acids and reduced cell viability.	Sialic Acids	73-85	glycoprotein hormone subunit alpha 2	Homo sapiens	43-65
33526785-15	2021	Taken together, it is the first report demonstrating that Atg5 is a sialoglycoprotein having alpha2,6- and alpha2,3-linked sialic acids and its desialylation by overexpressed Neu2 leads to its activation for autophagosome formation, which induced apoptosis/anoikis in OC.	Sialic Acids	123-135	autophagy related 5	Homo sapiens	58-62
33526785-15	2021	Taken together, it is the first report demonstrating that Atg5 is a sialoglycoprotein having alpha2,6- and alpha2,3-linked sialic acids and its desialylation by overexpressed Neu2 leads to its activation for autophagosome formation, which induced apoptosis/anoikis in OC.	Sialic Acids	123-135	immunoglobulin kappa variable 2-24	Homo sapiens	107-115
33526785-15	2021	Taken together, it is the first report demonstrating that Atg5 is a sialoglycoprotein having alpha2,6- and alpha2,3-linked sialic acids and its desialylation by overexpressed Neu2 leads to its activation for autophagosome formation, which induced apoptosis/anoikis in OC.	Sialic Acids	123-135	neuraminidase 2	Homo sapiens	175-179
33532574-6	2021	The level of alpha2,6-linked sialic acids in the two sublines was found to be consistent with the expression of a specific glycosyl transferase, ST6GAL1.	Sialic Acids	29-41	glycoprotein hormone subunit alpha 2	Homo sapiens	13-19
33532574-6	2021	The level of alpha2,6-linked sialic acids in the two sublines was found to be consistent with the expression of a specific glycosyl transferase, ST6GAL1.	Sialic Acids	29-41	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	145-152
33413322-6	2021	RESULTS: In the present study, we generated genetically engineered chicken DF-1 cell lines overexpressing transmembrane protease, serine 2 (TMPRSS2, which cleaves HA), ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3GAL1, which plays a role in synthesis of alpha-2,3 linked sialic acids to which avian-adapted viruses bind preferentially), or both.	Sialic Acids	281-293	transmembrane protease, serine 2	Gallus gallus	106-138
33413322-6	2021	RESULTS: In the present study, we generated genetically engineered chicken DF-1 cell lines overexpressing transmembrane protease, serine 2 (TMPRSS2, which cleaves HA), ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3GAL1, which plays a role in synthesis of alpha-2,3 linked sialic acids to which avian-adapted viruses bind preferentially), or both.	Sialic Acids	281-293	transmembrane protease, serine 2	Gallus gallus	140-147
33867926-4	2021	The recent discovery of CD33, a microglial Siglec, as a novel genetic risk factor for late-onset Alzheimer"s disease (AD), highlights the potential role of sialic acids in the development of microglial dysfunction and neuroinflammation in AD.	Sialic Acids	156-168	CD33 molecule	Homo sapiens	24-28
33614627-5	2020	The main receptor for SARS-CoV-2 is represented by the angiotensin-converting enzyme-2 (ACE-2), although it also binds to sialic acids linked to host cell surface gangliosides.	Sialic Acids	122-134	angiotensin converting enzyme 2	Homo sapiens	55-86
33614627-5	2020	The main receptor for SARS-CoV-2 is represented by the angiotensin-converting enzyme-2 (ACE-2), although it also binds to sialic acids linked to host cell surface gangliosides.	Sialic Acids	122-134	angiotensin converting enzyme 2	Homo sapiens	88-93
33420022-4	2021	Next, we show that sialic acids present on ACE2 prevent efficient spike/ACE2-interaction.	Sialic Acids	19-31	angiotensin converting enzyme 2	Homo sapiens	43-47
33420022-4	2021	Next, we show that sialic acids present on ACE2 prevent efficient spike/ACE2-interaction.	Sialic Acids	19-31	angiotensin converting enzyme 2	Homo sapiens	72-76
33397354-11	2021	Further experiments performed in HEK293T cells transiently overexpressing Siglec-E and CD36 and peritoneal macrophages demonstrated that depletion of cell surface sialic acids by treatment with sialyltransferase inhibitor or sialidase did not affect interaction between Siglec-E and CD36 but retarded Siglec-E-mediated inhibition on oxidized LDL uptake.	Sialic Acids	163-175	sialic acid binding Ig-like lectin E	Mus musculus	74-82
33397354-11	2021	Further experiments performed in HEK293T cells transiently overexpressing Siglec-E and CD36 and peritoneal macrophages demonstrated that depletion of cell surface sialic acids by treatment with sialyltransferase inhibitor or sialidase did not affect interaction between Siglec-E and CD36 but retarded Siglec-E-mediated inhibition on oxidized LDL uptake.	Sialic Acids	163-175	sialic acid binding Ig-like lectin E	Mus musculus	270-278
33397354-11	2021	Further experiments performed in HEK293T cells transiently overexpressing Siglec-E and CD36 and peritoneal macrophages demonstrated that depletion of cell surface sialic acids by treatment with sialyltransferase inhibitor or sialidase did not affect interaction between Siglec-E and CD36 but retarded Siglec-E-mediated inhibition on oxidized LDL uptake.	Sialic Acids	163-175	sialic acid binding Ig-like lectin E	Mus musculus	270-278
33340902-0	2021	Glycocalyx sialic acids regulate Nrf2-mediated signaling by fluid shear stress in human endothelial cells.	Sialic Acids	11-23	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
33908016-3	2021	Sialic acid chemical derivatization can be used to determine the isomeric linkage (alpha2,3 or alpha2,6) of sialic acids attached to N-glycans, while endoglycosidase F3 (Endo F3) can be enzymatically applied to preferentially release alpha1,6-linked core fucosylated glycans, further describing the linkage of fucose on N-glycans.	Sialic Acids	108-120	immunoglobulin kappa variable 2-24	Homo sapiens	83-91
33908016-3	2021	Sialic acid chemical derivatization can be used to determine the isomeric linkage (alpha2,3 or alpha2,6) of sialic acids attached to N-glycans, while endoglycosidase F3 (Endo F3) can be enzymatically applied to preferentially release alpha1,6-linked core fucosylated glycans, further describing the linkage of fucose on N-glycans.	Sialic Acids	108-120	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	95-103
33009208-1	2020	BACKGROUND: Sialic acids, e.g., alpha2,6-sialic acids (alpha2,6-SIAs), can link to conserved N-glycans of immunoglobulin G (IgG).	Sialic Acids	12-24	G protein-coupled receptor 162	Mus musculus	32-38
33320246-1	2021	The ST6GAL1 sialyltransferase, which adds alpha2-6 linked sialic acids to N-glycosylated proteins, is overexpressed in a wide range of human malignancies.	Sialic Acids	58-70	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	42-50
33009208-1	2020	BACKGROUND: Sialic acids, e.g., alpha2,6-sialic acids (alpha2,6-SIAs), can link to conserved N-glycans of immunoglobulin G (IgG).	Sialic Acids	12-24	G protein-coupled receptor 162	Mus musculus	55-61
33166339-8	2020	Given that ST6Gal-I activity modulated LPS-dependent signaling, we conducted pull-down assays using SNA (a lectin specific for alpha2-6 sialic acids) to show that the LPS receptor, TLR4, is a substrate for sialylation by ST6Gal-I.	Sialic Acids	136-148	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	11-19
33269329-0	2020	The SARS-COV-2 Spike Protein Binds Sialic Acids and Enables Rapid Detection in a Lateral Flow Point of Care Diagnostic Device.	Sialic Acids	35-47	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	15-20
33166339-8	2020	Given that ST6Gal-I activity modulated LPS-dependent signaling, we conducted pull-down assays using SNA (a lectin specific for alpha2-6 sialic acids) to show that the LPS receptor, TLR4, is a substrate for sialylation by ST6Gal-I.	Sialic Acids	136-148	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	127-135
32911203-6	2020	These results expand our understanding of hNEU enzyme specificity and suggest that naturally occurring modifications of sialic acids can play a role in regulating hNEU activity.	Sialic Acids	120-132	neuraminidase 1	Homo sapiens	42-46
33148698-1	2021	ST6Gal-I, an enzyme upregulated in numerous malignancies, adds alpha2-6-linked sialic acids to select membrane receptors, thereby modulating receptor signaling and cell phenotype.	Sialic Acids	79-91	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	0-8
33148698-1	2021	ST6Gal-I, an enzyme upregulated in numerous malignancies, adds alpha2-6-linked sialic acids to select membrane receptors, thereby modulating receptor signaling and cell phenotype.	Sialic Acids	79-91	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	63-71
32911203-6	2020	These results expand our understanding of hNEU enzyme specificity and suggest that naturally occurring modifications of sialic acids can play a role in regulating hNEU activity.	Sialic Acids	120-132	neuraminidase 1	Homo sapiens	163-167
32723915-15	2020	In contrast, HPyV12 VP1 engages terminal sialic acids in a manner similar to the human Trichodysplasia spinulosa-associated polyomavirus.	Sialic Acids	41-53	VP1	Human polyomavirus 12	20-23
32763973-10	2020	Protection from TNF-induced apoptosis was dependent on ST6Gal-I overexpression, since forced ST6Gal-I overexpression in normal gastric stem cell-differentiated monolayers inhibited TNF-induced apoptosis, and cleavage of alpha2,6-linked sialic acids from gastric cancer organoid-derived monolayers restored susceptibility to TNF-induced apoptosis.	Sialic Acids	236-248	tumor necrosis factor	Homo sapiens	16-19
32763973-10	2020	Protection from TNF-induced apoptosis was dependent on ST6Gal-I overexpression, since forced ST6Gal-I overexpression in normal gastric stem cell-differentiated monolayers inhibited TNF-induced apoptosis, and cleavage of alpha2,6-linked sialic acids from gastric cancer organoid-derived monolayers restored susceptibility to TNF-induced apoptosis.	Sialic Acids	236-248	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	55-63
32763973-10	2020	Protection from TNF-induced apoptosis was dependent on ST6Gal-I overexpression, since forced ST6Gal-I overexpression in normal gastric stem cell-differentiated monolayers inhibited TNF-induced apoptosis, and cleavage of alpha2,6-linked sialic acids from gastric cancer organoid-derived monolayers restored susceptibility to TNF-induced apoptosis.	Sialic Acids	236-248	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	93-101
33013909-5	2020	Among these receptors, Siglec 7 (p75/AIRM-1), LAIR-1 and IRp60, recognize ligands including sialic acids, extracellular matrix/collagen or aminophospholipids, respectively.	Sialic Acids	92-104	sialic acid binding Ig like lectin 7	Homo sapiens	23-31
33013909-5	2020	Among these receptors, Siglec 7 (p75/AIRM-1), LAIR-1 and IRp60, recognize ligands including sialic acids, extracellular matrix/collagen or aminophospholipids, respectively.	Sialic Acids	92-104	sialic acid binding Ig like lectin 7	Homo sapiens	33-36
33013909-5	2020	Among these receptors, Siglec 7 (p75/AIRM-1), LAIR-1 and IRp60, recognize ligands including sialic acids, extracellular matrix/collagen or aminophospholipids, respectively.	Sialic Acids	92-104	sialic acid binding Ig like lectin 7	Homo sapiens	37-43
33013909-5	2020	Among these receptors, Siglec 7 (p75/AIRM-1), LAIR-1 and IRp60, recognize ligands including sialic acids, extracellular matrix/collagen or aminophospholipids, respectively.	Sialic Acids	92-104	leukocyte associated immunoglobulin like receptor 1	Homo sapiens	46-52
33013909-5	2020	Among these receptors, Siglec 7 (p75/AIRM-1), LAIR-1 and IRp60, recognize ligands including sialic acids, extracellular matrix/collagen or aminophospholipids, respectively.	Sialic Acids	92-104	CD300a molecule	Homo sapiens	57-62
32548688-3	2020	Deletion of sur7 resulted in reduced conidiation capacity and impaired conidial quality, which was featured by slower germination, attenuated virulence, and reduced carbohydrate epitopes (beta-N-acetylglucosamine and sialic acids).	Sialic Acids	217-229	Sur7p	Saccharomyces cerevisiae S288C	12-16
32562764-3	2020	Furthermore, it is emphasized that the viral spike protein is prevented from binding gangliosides, which are composed of a glycosphingolipid with one or more sialic acids, in the presence of chloroquine or hydroxychloroquine.	Sialic Acids	158-170	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	45-50
32975669-1	2020	Neuraminidase (NEU)1 forms a multienzyme complex with beta-galactosidase (beta-GAL) and protective-protein/cathepsin (PPC) A, which cleaves sialic-acids from cell surface glycoconjugates.	Sialic Acids	140-152	neuraminidase 1	Mus musculus	0-20
32975669-1	2020	Neuraminidase (NEU)1 forms a multienzyme complex with beta-galactosidase (beta-GAL) and protective-protein/cathepsin (PPC) A, which cleaves sialic-acids from cell surface glycoconjugates.	Sialic Acids	140-152	galactosidase, beta 1	Mus musculus	54-72
31903639-0	2020	Sialic acids rather than glycosaminoglycans affect normal and sickle red blood cell rheology by binding to four major sites on fibrinogen.	Sialic Acids	0-12	fibrinogen beta chain	Homo sapiens	127-137
32350996-8	2020	Alterations in genes responsible for sialic acids (Sia) synthesis (GNE) and UDP-galactose (GALE) and lactosamine (LacNAc) (B4GALT1) profoundly affect circulating platelet counts.	Sialic Acids	37-49	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	67-70
32391973-5	2020	In this regard, siglec-7 and -9 are found on immune cells, such as natural killer cells, T-cells, and dendritic cells and they can promote immune suppression when binding to sialic acids expressed on target cells.	Sialic Acids	174-186	sialic acid binding Ig like lectin 7	Homo sapiens	16-31
32576593-4	2020	Serum amyloid P (SAP), a pentameric serum glycoprotein that has two sialic acids on each polypeptide, inhibits the differentiation of monocytes into fibrocytes and promotes human PBMCs to accumulate high extracellular levels of IL-10.	Sialic Acids	68-80	amyloid P component, serum	Homo sapiens	0-15
32576593-4	2020	Serum amyloid P (SAP), a pentameric serum glycoprotein that has two sialic acids on each polypeptide, inhibits the differentiation of monocytes into fibrocytes and promotes human PBMCs to accumulate high extracellular levels of IL-10.	Sialic Acids	68-80	amyloid P component, serum	Homo sapiens	17-20
32406685-5	2020	Addition of a single, or multiple sialic acids conferred remarkable enhancement to biophysical stability of human insulin, while maintaining its potency.	Sialic Acids	34-46	insulin	Homo sapiens	114-121
32609845-7	2020	Uptake of influenza virus particles by platelets requires binding to sialoglycans and results in the removal of sialic acids by the virus neuraminidase, a trigger for hepatic clearance of platelets.	Sialic Acids	112-124	neuraminidase 1	Homo sapiens	138-151
32126199-6	2020	Moreover, we demonstrated that alpha2-3-linked sialic acids on VSV G protein were involved in antagonizing NF-kappaB- and MAPK-mediated pro-inflammatory responses.	Sialic Acids	47-59	immunoglobulin kappa variable 2-24	Homo sapiens	31-39
32126199-6	2020	Moreover, we demonstrated that alpha2-3-linked sialic acids on VSV G protein were involved in antagonizing NF-kappaB- and MAPK-mediated pro-inflammatory responses.	Sialic Acids	47-59	nuclear factor kappa B subunit 1	Homo sapiens	107-116
31697432-0	2020	On the structure and function of Escherichia coli YjhC: an oxidoreductase involved in bacterial sialic acid metabolism.	Sialic Acids	96-107	oxidoreductase	Escherichia coli	59-73
31697432-3	2020	The role of the yjhBC encoded proteins is not known-here we demonstrate that the enzyme YjhC is an oxidoreductase involved in bacterial sialic acid degradation.	Sialic Acids	136-147	oxidoreductase	Escherichia coli	99-113
32326143-3	2020	It was reported that the shift from glycoproteins containing alpha-2,6-linked sialic acids to those that contain alpha-2,3 was associated with the onset of common types of arthritis.	Sialic Acids	78-90	glycoprotein hormone subunit alpha 2	Homo sapiens	61-68
31753616-3	2020	If and how intrinsic sources of negative charge in mucins, e.g., sulfated glycans and sialic acid residues, are relevant for the tribological behavior of mucin solutions has, however, not been addressed yet.	Sialic Acids	86-97	LOC100508689	Homo sapiens	51-56
32164705-8	2020	Moreover, the function of sialic acids on fibronectin-integrin alpha5beta1 interaction were assayed by immunoprecipitation and ELISA.	Sialic Acids	26-38	fibronectin 1	Homo sapiens	42-53
32164705-11	2020	RESULTS: (1) Downregulation of NEU1 was primarily responsible for aberrant expression of sialic acids in bladder cancer cells.	Sialic Acids	89-101	neuraminidase 1	Mus musculus	31-35
31846645-7	2020	Peptide-mediated modulation of Orai1 involved cell surface sialic acids as inhibition of sialylation as well as chemical blocking of sialic acids reduced rapid cytoplasmic uptake, which could be reconstituted by thapsigargin.	Sialic Acids	59-71	ORAI calcium release-activated calcium modulator 1	Homo sapiens	31-36
31846645-7	2020	Peptide-mediated modulation of Orai1 involved cell surface sialic acids as inhibition of sialylation as well as chemical blocking of sialic acids reduced rapid cytoplasmic uptake, which could be reconstituted by thapsigargin.	Sialic Acids	133-145	ORAI calcium release-activated calcium modulator 1	Homo sapiens	31-36
31753616-4	2020	In this manuscript, we show that the removal of either sialic acid or sulfate groups, which comprise only a minor amount of the total molecular weight, from MUC5B drastically reduces its lubricity.	Sialic Acids	55-66	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	157-162
31888963-11	2020	The additional analysis of CD32a from monocytes revealed different features than observed for CD16a including the presence of a predominantly biantennary complex-type N-glycans with two sialic acids at both sites (N64 and N145).	Sialic Acids	186-198	Fc gamma receptor IIa	Homo sapiens	27-32
31892066-3	2020	Here, we developed a whole-surface accessible method of accurate SERS quantification of SA level on a single cell, in which silver nanoparticles functionalized with 4-mercaptophenylboric acid and 4-mercaptobenzenitrile was used as the background-free SERS probe.	Sialic Acids	88-90	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	65-69
31892066-3	2020	Here, we developed a whole-surface accessible method of accurate SERS quantification of SA level on a single cell, in which silver nanoparticles functionalized with 4-mercaptophenylboric acid and 4-mercaptobenzenitrile was used as the background-free SERS probe.	Sialic Acids	88-90	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	251-255
31831633-7	2020	M2-like macrophages induced the expression of the glycosyltransferase ST6GALNAC1, an enzyme that adds sialic acid to O-linked GalNAc residues, promoting the formation of tumor-associated sialyl-Tn (sTn) O-glycans.	Sialic Acids	102-113	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	Homo sapiens	70-80
31801810-11	2020	Collectively, PSA-NCAM colocalized with VGluT3+/CCK+ cells in the CA1 region of the hippocampus may play a unique role in the regulation of antidepressant efficacy via the serotonergic pathway.SIGNIFICANCE STATEMENTPolysialic acid (PSA) is composed of eight or more alpha2,8-linked sialic acids.	Sialic Acids	282-294	neural cell adhesion molecule 1	Mus musculus	18-22
31801810-11	2020	Collectively, PSA-NCAM colocalized with VGluT3+/CCK+ cells in the CA1 region of the hippocampus may play a unique role in the regulation of antidepressant efficacy via the serotonergic pathway.SIGNIFICANCE STATEMENTPolysialic acid (PSA) is composed of eight or more alpha2,8-linked sialic acids.	Sialic Acids	282-294	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8	Mus musculus	40-46
31801810-11	2020	Collectively, PSA-NCAM colocalized with VGluT3+/CCK+ cells in the CA1 region of the hippocampus may play a unique role in the regulation of antidepressant efficacy via the serotonergic pathway.SIGNIFICANCE STATEMENTPolysialic acid (PSA) is composed of eight or more alpha2,8-linked sialic acids.	Sialic Acids	282-294	cholecystokinin	Mus musculus	48-51
31947579-6	2020	Our data also indicated that, while the mammalian ST8Sia family is comprised of six subfamilies forming di-, oligo-, or polymers of alpha2,8-linked sialic acids, the fish ST8Sia family, amounting to a total of 10 genes in fish, appears to be much more diverse and shows a patchy distribution among fish species.	Sialic Acids	148-160	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	132-140
31998308-3	2019	More recent evidence suggests that terminal alpha2,6 linked sialic acids can be attached to antibodies post IgG secretion.	Sialic Acids	60-72	calmegin	Mus musculus	44-52
31829566-8	2020	Complex N-glycans from alpha-1-acid glycoprotein were analyzed using this approach, revealing that a limited number of alpha2-6 linked sialic acids were present, with biantennary, triantennary, and tetraantennary N-glycans of alpha-1-acid glycoprotein generally containing 0 or 1 alpha2-6 linked sialic acid.	Sialic Acids	135-146	immunoglobulin binding protein 1	Homo sapiens	119-127
31913287-4	2020	Moreover, IgA1 and IgA2 have different glycosylation profiles, with IgA1 possessing more sialic acid than IgA2.	Sialic Acids	89-100	immunoglobulin heavy constant alpha 1	Homo sapiens	10-14
31913287-4	2020	Moreover, IgA1 and IgA2 have different glycosylation profiles, with IgA1 possessing more sialic acid than IgA2.	Sialic Acids	89-100	immunoglobulin heavy constant alpha 1	Homo sapiens	68-72
31913287-5	2020	Removal of sialic acid increases the pro-inflammatory capacity of IgA1, making it comparable to IgA2.	Sialic Acids	11-22	immunoglobulin heavy constant alpha 1	Homo sapiens	66-70
31829566-2	2020	A capillary electrophoresis method is reported that integrates a unique combination of enzymes and lectins to modify sialylated N-glycans in real time in the capillary so that N-glycan structures containing alpha2-6 linked sialic acid are easily separated, detected, and quantified.	Sialic Acids	223-234	immunoglobulin binding protein 1	Homo sapiens	207-215
31216452-4	2020	Evidences cleared that EPO"s activity increased by numbers of N-glycan moieties with presence of sialic acids at their terminus.	Sialic Acids	97-109	erythropoietin	Homo sapiens	23-26
31829566-3	2020	In this study, N-glycans were sequentially cleaved by enzymes at the head of the separation capillary so that the presence of alpha2-6 linked sialic acids corresponded to a shift in the analyte migration time in a manner that enabled interpretation of the N-glycan structure.	Sialic Acids	142-154	immunoglobulin binding protein 1	Homo sapiens	126-134
31829566-5	2020	With this treatment complete, a third zone of alpha2-3,6,8 sialidase converted the remaining alpha2-6-linked sialic acid to terminal galactose.	Sialic Acids	109-120	immunoglobulin binding protein 1	Homo sapiens	93-101
31829566-6	2020	With these enzyme processing steps, the alpha2-6 linked sialic acid residues on an N-glycan correlated directly to the number of terminal galactose residues that remained.	Sialic Acids	56-67	immunoglobulin binding protein 1	Homo sapiens	40-48
31829566-8	2020	Complex N-glycans from alpha-1-acid glycoprotein were analyzed using this approach, revealing that a limited number of alpha2-6 linked sialic acids were present, with biantennary, triantennary, and tetraantennary N-glycans of alpha-1-acid glycoprotein generally containing 0 or 1 alpha2-6 linked sialic acid.	Sialic Acids	135-147	immunoglobulin binding protein 1	Homo sapiens	119-127
31678878-8	2020	Blood Pb levels were negatively correlated with salivary sialic acids, in which IL-6 played as a mediator of the association between blood Pb levels and saliva sialic acid concentrations according to the mediation model.	Sialic Acids	57-69	interleukin 6	Homo sapiens	80-84
31678878-8	2020	Blood Pb levels were negatively correlated with salivary sialic acids, in which IL-6 played as a mediator of the association between blood Pb levels and saliva sialic acid concentrations according to the mediation model.	Sialic Acids	57-68	interleukin 6	Homo sapiens	80-84
32053088-1	2020	Sialuria is a rare inborn error of metabolism caused by excessive synthesis of sialic acid due to the mutation in the binding site of the cytidine monophosphate-sialic acid of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE/MNK).	Sialic Acids	79-90	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	214-217
32053088-1	2020	Sialuria is a rare inborn error of metabolism caused by excessive synthesis of sialic acid due to the mutation in the binding site of the cytidine monophosphate-sialic acid of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE/MNK).	Sialic Acids	79-90	ATPase copper transporting alpha	Homo sapiens	218-221
31449929-4	2019	As APBA has a boronic acid group, it can form a high-affinity complex with sialic acids present in the ocular mucin, which contributes to extension of corneal retention time and improvement of drug delivery.	Sialic Acids	75-87	LOC100508689	Homo sapiens	110-115
31861617-4	2019	Here we focus on the role of Siglec-1, a sialic acid-binding type I lectin receptor potently upregulated by type I interferons on DCs, that acts as a double edge sword, containing viral replication through the induction of antiviral immunity, but also favoring viral spread within tissues.	Sialic Acids	41-52	sialic acid binding Ig like lectin 1	Homo sapiens	29-37
31861617-5	2019	Such is the case for distant enveloped viruses like human immunodeficiency virus (HIV)-1 or Ebola virus (EBOV), which incorporate sialic acid-containing gangliosides on their viral membrane and are effectively recognized by Siglec-1.	Sialic Acids	130-141	sialic acid binding Ig like lectin 1	Homo sapiens	224-232
31796537-9	2019	Knocking out CasD1 removed 7,9-O- and 9-O-acetyl Sia expression, confirming previous reports.	Sialic Acids	49-52	CAS1 domain containing 1	Homo sapiens	13-18
30805710-10	2019	Lectin microarray analyses revealed glycosylation of CD133 by sialic acids as the major glycosylation among diverse others responsible for the glycosylation of exosomal CD133.	Sialic Acids	62-74	prominin 1	Homo sapiens	53-58
30805710-10	2019	Lectin microarray analyses revealed glycosylation of CD133 by sialic acids as the major glycosylation among diverse others responsible for the glycosylation of exosomal CD133.	Sialic Acids	62-74	prominin 1	Homo sapiens	169-174
31824923-4	2019	NEU3 was able to modify the sialic acid content of purified LFA-1 in vitro.	Sialic Acids	28-39	neuraminidase 3	Homo sapiens	0-4
31824923-4	2019	NEU3 was able to modify the sialic acid content of purified LFA-1 in vitro.	Sialic Acids	28-39	integrin subunit alpha L	Homo sapiens	60-65
31781090-11	2019	Comparable results were achieved, when sialic acids were targeted by neuraminidase digestion, indicating a sialic acid dependent inhibition of NET release.	Sialic Acids	39-51	neuraminidase 1	Bos taurus	69-82
31730330-3	2019	Herein, we described a sequential selective derivatization method, by which alpha-2,6- and alpha-2,3-linked sialic acids are sequentially labeled with methylamide incorporated with different sta-ble-isotope.	Sialic Acids	76-120	GCY	Homo sapiens	191-194
31577134-1	2019	Sialic acids form the terminal sugars in glycan chains on glycoproteins via alpha2,3, alpha2,6, or alpha2,8 linkages, and structural isomers of sialyl linkages play various functional roles in cell recognition and other physiological processes.	Sialic Acids	0-12	immunoglobulin kappa variable 2-24	Homo sapiens	76-84
31577134-1	2019	Sialic acids form the terminal sugars in glycan chains on glycoproteins via alpha2,3, alpha2,6, or alpha2,8 linkages, and structural isomers of sialyl linkages play various functional roles in cell recognition and other physiological processes.	Sialic Acids	0-12	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	86-94
31577134-1	2019	Sialic acids form the terminal sugars in glycan chains on glycoproteins via alpha2,3, alpha2,6, or alpha2,8 linkages, and structural isomers of sialyl linkages play various functional roles in cell recognition and other physiological processes.	Sialic Acids	0-12	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	99-107
31449929-10	2019	APBA-ChS, which is present on the surface of DEX-NLC and contains the boronic acid group, can form complex with sialic acids in the ocular mucin, hence leading to prolonged precorneal retention.	Sialic Acids	112-124	LOC100508689	Homo sapiens	139-144
31649671-4	2019	Here, we initiated a comprehensive study on the modulation of TLR4 sialylation in Leishmania donovani (L. d)-infected macrophages by a mammalian sialidase/neuraminidase-1 (Neu1) having substrate specificity toward alpha2,3-linked sialic acids.	Sialic Acids	230-242	neuraminidase 1	Homo sapiens	145-170
31610800-1	2019	BACKGROUND: The ST6Gal-I glycosyltransferase, which adds alpha2-6-linked sialic acids to N-glycosylated proteins is upregulated in a wide range of malignancies including ovarian cancer.	Sialic Acids	73-85	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	16-24
31610800-1	2019	BACKGROUND: The ST6Gal-I glycosyltransferase, which adds alpha2-6-linked sialic acids to N-glycosylated proteins is upregulated in a wide range of malignancies including ovarian cancer.	Sialic Acids	73-85	immunoglobulin binding protein 1	Homo sapiens	57-65
31695778-10	2019	N-glycomics of CEA revealed that complex N-glycans are capped with alpha2-3 linked sialic acid (Neu5Acalpha2-3Galbeta1-4GlcNAc).	Sialic Acids	83-94	CEA cell adhesion molecule 5	Homo sapiens	15-18
31649671-4	2019	Here, we initiated a comprehensive study on the modulation of TLR4 sialylation in Leishmania donovani (L. d)-infected macrophages by a mammalian sialidase/neuraminidase-1 (Neu1) having substrate specificity toward alpha2,3-linked sialic acids.	Sialic Acids	230-242	neuraminidase 1	Homo sapiens	172-176
31649671-14	2019	This novel finding establishes a link between enhanced alpha2,3-linked sialic acids on TLR4 and reduced membrane-bound Neu1 which plays a significant role for inhibiting downstream signaling to establish successful infection in the host cells.	Sialic Acids	71-83	neuraminidase 1	Homo sapiens	119-123
31167913-1	2019	Middle East respiratory syndrome coronavirus (MERS-CoV) uses the S1B domain of its spike protein to bind to dipeptidyl peptidase 4 (DPP4), its functional receptor, and its S1A domain to bind to sialic acids.	Sialic Acids	194-206	dipeptidyl peptidase 4	Homo sapiens	132-136
31681675-9	2019	Results: Data showed a significant correlation between salivary SOD, GPx, MDA, and SA in group 1, group 2, and group 3.	Sialic Acids	83-85	superoxide dismutase 1	Homo sapiens	64-67
31632959-5	2019	Plant-derived HER2-IgE exhibited N-glycans terminating with GlcNAc, galactose or sialic acid, lacking, or carrying core fucose and xylose.	Sialic Acids	81-92	immunoglobulin heavy constant epsilon	Homo sapiens	14-22
31243129-1	2019	Group A rotaviruses, an important cause of severe diarrhea in children and young animals, initiate infection via interactions of the VP8* domain of the VP4 spike protein with cell surface sialic acids (SAs) or histo-blood group antigens (HBGAs).	Sialic Acids	188-200	outer capsid spike protein VP4	Rotavirus A	152-155
31243129-1	2019	Group A rotaviruses, an important cause of severe diarrhea in children and young animals, initiate infection via interactions of the VP8* domain of the VP4 spike protein with cell surface sialic acids (SAs) or histo-blood group antigens (HBGAs).	Sialic Acids	202-205	outer capsid spike protein VP4	Rotavirus A	152-155
31243129-8	2019	In addition, these data also suggested that P[5]-bearing strains have potential for cross-species transmission.IMPORTANCE Group A rotaviruses initiate infection through the binding of the VP8* domain of the VP4 protein to sialic acids (SAs) or histo-blood group antigens (HBGAs).	Sialic Acids	222-234	outer capsid spike protein VP4	Rotavirus A	207-210
31243129-8	2019	In addition, these data also suggested that P[5]-bearing strains have potential for cross-species transmission.IMPORTANCE Group A rotaviruses initiate infection through the binding of the VP8* domain of the VP4 protein to sialic acids (SAs) or histo-blood group antigens (HBGAs).	Sialic Acids	236-239	outer capsid spike protein VP4	Rotavirus A	207-210
31636638-7	2019	Interestingly, inflammation of mouse cremaster tissues or ear skin as induced by TNF-stimulation induced a rapid (within 16 h) remodeling of the LV glycocalyx, as observed by reduced expression of HS and galactosyl moieties, whilst levels of alpha2,3-linked sialic acids remains unchanged.	Sialic Acids	258-270	tumor necrosis factor	Mus musculus	81-84
31744945-4	2019	Here we present a review of current knowledge in GNE myopathy, a rare neuromuscular disorder caused by mutations in the GNE gene that catalyzes the biosynthesis of sialic acid.	Sialic Acids	164-175	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	49-52
31744945-4	2019	Here we present a review of current knowledge in GNE myopathy, a rare neuromuscular disorder caused by mutations in the GNE gene that catalyzes the biosynthesis of sialic acid.	Sialic Acids	164-175	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	120-123
31332008-7	2019	Ldlr -/- mice with human-like Cmah deficiency fed a sialic acids (Sias)-free high-fat diet (HFD) showed ~1.9-fold increased atherogenesis over Cmah wild-type Ldlr -/- mice, associated with elevated macrophage cytokine expression and enhanced hyperglycemia.	Sialic Acids	52-64	low density lipoprotein receptor	Mus musculus	0-4
31332008-7	2019	Ldlr -/- mice with human-like Cmah deficiency fed a sialic acids (Sias)-free high-fat diet (HFD) showed ~1.9-fold increased atherogenesis over Cmah wild-type Ldlr -/- mice, associated with elevated macrophage cytokine expression and enhanced hyperglycemia.	Sialic Acids	52-64	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	30-34
31332008-7	2019	Ldlr -/- mice with human-like Cmah deficiency fed a sialic acids (Sias)-free high-fat diet (HFD) showed ~1.9-fold increased atherogenesis over Cmah wild-type Ldlr -/- mice, associated with elevated macrophage cytokine expression and enhanced hyperglycemia.	Sialic Acids	52-64	low density lipoprotein receptor	Homo sapiens	158-162
31332008-7	2019	Ldlr -/- mice with human-like Cmah deficiency fed a sialic acids (Sias)-free high-fat diet (HFD) showed ~1.9-fold increased atherogenesis over Cmah wild-type Ldlr -/- mice, associated with elevated macrophage cytokine expression and enhanced hyperglycemia.	Sialic Acids	66-70	low density lipoprotein receptor	Mus musculus	0-4
31332008-7	2019	Ldlr -/- mice with human-like Cmah deficiency fed a sialic acids (Sias)-free high-fat diet (HFD) showed ~1.9-fold increased atherogenesis over Cmah wild-type Ldlr -/- mice, associated with elevated macrophage cytokine expression and enhanced hyperglycemia.	Sialic Acids	66-70	low density lipoprotein receptor	Homo sapiens	158-162
30852321-7	2019	Enzymatic removal of sialic acids results in the removal of galactose residues from the EPS upon subsequent treatment with beta-galactosidase, indicating a linkage between galactose and sialic acid at the terminus of glycan chains.	Sialic Acids	21-33	galactosidase beta 1	Homo sapiens	123-141
31598119-0	2019	Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N-Acetylneuraminate Lyase in a Continuous Flow Reactor.	Sialic Acids	28-39	N-acetylneuraminate pyruvate lyase	Homo sapiens	70-95
30771974-5	2019	The added SA selectively recognized the C-dots, leading to the fluorescence quenching of the C-dots in a linear range of 80-4000 muM with a detection limit of 54 muM.	Sialic Acids	10-12	latexin	Homo sapiens	129-132
30771974-5	2019	The added SA selectively recognized the C-dots, leading to the fluorescence quenching of the C-dots in a linear range of 80-4000 muM with a detection limit of 54 muM.	Sialic Acids	10-12	latexin	Homo sapiens	162-165
31247730-4	2019	Herein, we report a novel approach for Abeta-SA interaction analysis and highly sensitive Abeta detection by mimicing the cell surface presentation of SA clusters through engineering of SA-modified peptide nanofiber (SANF).	Sialic Acids	45-47	amyloid beta precursor protein	Homo sapiens	39-44
31247730-4	2019	Herein, we report a novel approach for Abeta-SA interaction analysis and highly sensitive Abeta detection by mimicing the cell surface presentation of SA clusters through engineering of SA-modified peptide nanofiber (SANF).	Sialic Acids	151-153	amyloid beta precursor protein	Homo sapiens	39-44
31247730-6	2019	Using FAM-labeled Abeta fragments of Abeta1-16, Abeta16-23, and Abeta24-40, the interaction between Abeta and SA was evaluated by the fluorescence titration experiments.	Sialic Acids	110-112	amyloid beta precursor protein	Homo sapiens	18-23
31247730-6	2019	Using FAM-labeled Abeta fragments of Abeta1-16, Abeta16-23, and Abeta24-40, the interaction between Abeta and SA was evaluated by the fluorescence titration experiments.	Sialic Acids	110-112	amyloid beta precursor protein	Homo sapiens	37-42
30597004-1	2019	We used Casd1-deficient mice to confirm that this enzyme is responsible for 9-O-acetylation of sialic acids in vivo.	Sialic Acids	95-107	CAS1 domain containing 1	Mus musculus	8-13
31950000-4	2020	Plasma SA significantly increased with an increase in lipid peroxidation of RBCs (LPO-RBC) (P < 0.001) in the diabetic patients without complication.	Sialic Acids	7-9	lactoperoxidase	Homo sapiens	82-85
31950000-5	2020	RBC-SA significantly decreased with an elevation in LPO-RBC (P < 0.001) in all the diabetic patients and those with nephropathy.	Sialic Acids	4-6	lactoperoxidase	Homo sapiens	52-55
31950000-7	2020	In multiple logistic regression analysis, RBC-SA was independently related to LPO-RBC in all the diabetic patients and those with nephropathy.	Sialic Acids	46-48	lactoperoxidase	Homo sapiens	78-81
31950000-8	2020	We conclude that the induction of LPO-RBC in diabetic patients and those with nephropathy may influence the SA decomposition of RBC membrane, thereby altering its functions and transporter activities.	Sialic Acids	108-110	lactoperoxidase	Homo sapiens	34-37
31064828-0	2019	Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway.	Sialic Acids	44-56	myosin heavy chain 9	Homo sapiens	0-32
31064828-0	2019	Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway.	Sialic Acids	44-56	transmembrane immune signaling adaptor TYROBP	Homo sapiens	129-134
31064828-0	2019	Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway.	Sialic Acids	44-56	spleen associated tyrosine kinase	Homo sapiens	135-138
31064828-3	2019	We identified that cell surface NMHC-IIA recognized sialic acids on sialylated RNA viruses during early infections and interacted with an immune adaptor DNAX activation protein of 12 kDa (DAP12) to recruit downstream spleen tyrosine kinase (Syk), leading to suppressed virus-triggered proinflammatory responses.	Sialic Acids	52-64	myosin heavy chain 9	Homo sapiens	32-40
31064828-7	2019	Here, we identified that NMHC-IIA recognizes sialic acids on sialylated RNA viruses, vesicular stomatitis virus (VSV) and porcine reproductive and respiratory syndrome virus (PRRSV).	Sialic Acids	45-57	myosin heavy chain 9	Homo sapiens	25-33
30641231-4	2019	Seven intact glycan isomers with alpha2-6 linked sialic acids, five of them also fucosylated, were the most meaningful to distinguish between PDAC and ChrP patients.	Sialic Acids	49-61	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	33-41
31143186-6	2019	The abundance of sialic acids on tumor cell surface is hypothesized to regulate NK cell-mediated cytotoxicity by interacting with Siglec-7 and Siglec-9, causing a dampening of NK cell activation pathways.	Sialic Acids	17-29	sialic acid binding Ig like lectin 7	Homo sapiens	130-138
31143186-6	2019	The abundance of sialic acids on tumor cell surface is hypothesized to regulate NK cell-mediated cytotoxicity by interacting with Siglec-7 and Siglec-9, causing a dampening of NK cell activation pathways.	Sialic Acids	17-29	sialic acid binding Ig like lectin 9	Homo sapiens	143-151
30578646-3	2019	Here, we report that CRISPR/Cas9-mediated knock out of the CMAS gene, encoding a key enzyme in the sialylation pathway, in the mouse colorectal cancer MC38 cell line completely abrogated cell surface expression of sialic acids (MC38-Sianull ) and, unexpectedly, significantly increased in vivo tumor growth compared to the control MC38-MOCK cells.	Sialic Acids	214-226	cytidine monophospho-N-acetylneuraminic acid synthetase	Mus musculus	59-63
30626673-10	2019	A VP2 (major capsid protein) EVE sequence from a mouse genome assembled into capsids that had a similar structure and biophysical properties to extant parvoviruses and also bound sialic acids and entered rodent cells.	Sialic Acids	179-191	complement factor D	Rattus norvegicus	29-32
30866786-1	2019	Influenza virus haemagglutinin (HA) and neuraminidase (NA) are involved in the recognition and modulation of sialic acids on the cell surface as the virus receptor.	Sialic Acids	109-121	neuraminidase 1	Homo sapiens	40-53
30716138-4	2019	Knockout of MUC1 in HT29-MTX cells or removal of MUC1 sialic acids by neuraminidase treatment reduced Salmonella apical invasion but did not affect lateral invasion that is not hampered by a defensive barrier.	Sialic Acids	54-66	mucin 1, cell surface associated	Homo sapiens	49-53
30716138-4	2019	Knockout of MUC1 in HT29-MTX cells or removal of MUC1 sialic acids by neuraminidase treatment reduced Salmonella apical invasion but did not affect lateral invasion that is not hampered by a defensive barrier.	Sialic Acids	54-66	neuraminidase 1	Homo sapiens	70-83
30468716-1	2019	Sialic acids (Sia) are involved in various biological and pathological processes, and are often found attached to non-reducing ends of glycans through either alpha2,3- or alpha2,6-linkages.	Sialic Acids	0-12	immunoglobulin kappa variable 2-24	Homo sapiens	158-167
30866786-1	2019	Influenza virus haemagglutinin (HA) and neuraminidase (NA) are involved in the recognition and modulation of sialic acids on the cell surface as the virus receptor.	Sialic Acids	109-121	neuraminidase 1	Homo sapiens	55-57
30866786-8	2019	Using recombinant viruses with altered HA bindings preference between alpha2,3- and alpha2,6-linked sialic acids, we also found that NA function against different substrates is correlated with the HA-receptor specificity.	Sialic Acids	100-112	neuraminidase 1	Homo sapiens	133-135
31767053-4	2019	Determination of the sialic acids" content and complexity by glycan mapping therefore appears critical to ensure the quality and efficacy of the EPO therapeutic products.	Sialic Acids	21-33	erythropoietin	Homo sapiens	145-148
30559744-6	2018	While CD22 binds alpha2,6-linked sialic acids, Siglec-G can bind both alpha2,6-linked and alpha2,3-linked sialic acids.	Sialic Acids	33-45	CD22 molecule	Homo sapiens	6-10
30340996-0	2018	De-O-Acetylation of mucin-derived sialic acids by recombinant NanS-p esterases of Escherichia coli O157:H7 strain EDL933.	Sialic Acids	34-46	N-acetylneuraminate synthase	Bos taurus	62-66
30349315-6	2018	Loss of Neu5Ac by enzymatic removal or siRNA knockdown of cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS), which activates cellular sialic acids for glycoprotein conjugation, had no significant effect on cell proliferation, but decreased the ability of BPLER to invade through a basement membrane.	Sialic Acids	149-161	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	58-115
30220337-0	2018	Role of L-selectin on leukocytes in the binding of sialic acids on sperm surface during the phagocytosis of sperm in female reproductive tract.	Sialic Acids	51-63	selectin L	Homo sapiens	8-18
30220337-6	2018	Since the sialic acids are considered as ligands of L-selectin, we propose that leukocytes bind to the sperm through the L-selectin on leukocytes and sialic acid on sperm surface during the sperm phagocytosis in female reproductive tract.	Sialic Acids	10-22	selectin L	Homo sapiens	52-62
30220337-6	2018	Since the sialic acids are considered as ligands of L-selectin, we propose that leukocytes bind to the sperm through the L-selectin on leukocytes and sialic acid on sperm surface during the sperm phagocytosis in female reproductive tract.	Sialic Acids	10-22	selectin L	Homo sapiens	121-131
30349315-6	2018	Loss of Neu5Ac by enzymatic removal or siRNA knockdown of cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS), which activates cellular sialic acids for glycoprotein conjugation, had no significant effect on cell proliferation, but decreased the ability of BPLER to invade through a basement membrane.	Sialic Acids	149-161	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	117-121
30214141-4	2018	The extracts were treated with neuraminidase A to cleave the sialic acids in MUC5AC.	Sialic Acids	61-73	neuraminidase 1	Homo sapiens	31-44
30214141-4	2018	The extracts were treated with neuraminidase A to cleave the sialic acids in MUC5AC.	Sialic Acids	61-73	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	77-83
29735266-1	2018	OBJECTIVES: Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism.	Sialic Acids	52-64	neuraminidase 1	Mus musculus	12-27
29706017-12	2018	Deposition of C3 fragments is also needed, which implies that in aHUS, the problem is in simultaneous recognition of C3 fragments and glycosaminoglycans or sialic acids by FH, not just the inability of FH to recognize glomerular endothelium as such.	Sialic Acids	156-168	ferritin heavy polypeptide 1	Mus musculus	172-174
30424240-4	2018	Glycoprotein mucin is tested here as a good candidate to assemble the microparticles because of high charge due to sialic acids, mucoadhesive properties, and a tendency to self-assemble, forming gels.	Sialic Acids	115-127	LOC100508689	Homo sapiens	13-18
30424240-6	2018	Desialylated mucin has weaker binding to the crystals most probably due to electrostatic interactions between sialic acids and calcium ions on the crystal surface.	Sialic Acids	110-122	LOC100508689	Homo sapiens	13-18
29902433-3	2018	(2018) show that binding to a specific sialylated cellular protein facilitates infection: engagement of sialic acids linked to the Ca2+ channel CaV1.2 induces Ca2+ oscillations, which promote infectious entry.	Sialic Acids	104-116	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	144-150
29735266-1	2018	OBJECTIVES: Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism.	Sialic Acids	52-64	neuraminidase 1	Mus musculus	29-33
29341588-5	2018	To investigate the substrate activity of 9- O-acetylated sialic acids (Neu5,9Ac2), we synthesized an acetylated fluorogenic hNEU substrate 2"-(4-methylumbelliferyl)-9- O-acetyl-alpha-d- N-acetylneuraminic acid.	Sialic Acids	57-69	neuraminidase 1	Homo sapiens	124-128
29725338-5	2018	CD22 (also known as Siglec-2) is an inhibitory molecule preferentially expressed in B lymphocytes (B cells) and is constitutively bound and functionally regulated by alpha2,6 sialic acids expressed on the same cell (cis-ligands).	Sialic Acids	175-187	CD22 antigen	Mus musculus	0-4
29725338-5	2018	CD22 (also known as Siglec-2) is an inhibitory molecule preferentially expressed in B lymphocytes (B cells) and is constitutively bound and functionally regulated by alpha2,6 sialic acids expressed on the same cell (cis-ligands).	Sialic Acids	175-187	CD22 antigen	Mus musculus	20-28
29725338-7	2018	When B cells are activated by B cell antigen receptor (BCR) ligation, both GSC718 and GSC839 downregulate proliferation of B cells, and this regulation requires both CD22 and alpha2,6 sialic acids.	Sialic Acids	184-196	BCR activator of RhoGEF and GTPase	Mus musculus	30-53
29725338-7	2018	When B cells are activated by B cell antigen receptor (BCR) ligation, both GSC718 and GSC839 downregulate proliferation of B cells, and this regulation requires both CD22 and alpha2,6 sialic acids.	Sialic Acids	184-196	BCR activator of RhoGEF and GTPase	Mus musculus	55-58
29328525-3	2018	These interactions were suggested to depend on sialic acid-containing glycans of MMP-9, but the roles of sialic acids in the interaction between SSL5 and MMP-9 are still controversial.	Sialic Acids	105-117	matrix metallopeptidase 9	Homo sapiens	154-159
29483296-3	2018	Here, we describe biochemical characterisation of recombinant NanH, including its action on host-relevant sialoglycans such as sialyl Lewis A and sialyl Lewis X (SLeA/X), and on human cell-attached sialic acids directly, uncovering that it is a highly active broad specificity sialidase.	Sialic Acids	198-210	neuraminidase 1	Homo sapiens	62-66
29146181-3	2018	Cis-ligands are most extensively studied in CD22 (also known as Siglec-2), an inhibitory B lymphocyte receptor specifically recognizing alpha2,6 sialic acids.	Sialic Acids	145-157	CD22 antigen	Mus musculus	44-48
29203541-2	2018	This bacterium can utilize free sialic acid for growth, but most sialic acids in the GI tract are sequestered on macromolecules, such as the mucin proteins of mucus or glycoconjugates in host cells.	Sialic Acids	65-77	LOC100508689	Homo sapiens	141-146
29146181-3	2018	Cis-ligands are most extensively studied in CD22 (also known as Siglec-2), an inhibitory B lymphocyte receptor specifically recognizing alpha2,6 sialic acids.	Sialic Acids	145-157	CD22 antigen	Mus musculus	64-72
28958711-4	2017	Herein, we employed tandem mass spectrometry (MS/MS) to demonstrate that the N-glycanson the recombinant human integrin binding sialoprotein (rhiBSP) are also enriched in sialic acids (SAs) at their termini.	Sialic Acids	171-183	integrin binding sialoprotein	Homo sapiens	111-140
29029079-5	2017	Using glycan maturation-defective CHO mutant cells, we further revealed that the presence of terminal sialic acids in the N-glycans of EC-SOD enhanced both the secretion and furin-mediated C-terminal cleavage of EC-SOD.	Sialic Acids	102-114	superoxide dismutase 3	Homo sapiens	135-141
29029079-5	2017	Using glycan maturation-defective CHO mutant cells, we further revealed that the presence of terminal sialic acids in the N-glycans of EC-SOD enhanced both the secretion and furin-mediated C-terminal cleavage of EC-SOD.	Sialic Acids	102-114	furin	Cricetulus griseus	174-179
29029079-5	2017	Using glycan maturation-defective CHO mutant cells, we further revealed that the presence of terminal sialic acids in the N-glycans of EC-SOD enhanced both the secretion and furin-mediated C-terminal cleavage of EC-SOD.	Sialic Acids	102-114	superoxide dismutase 3	Homo sapiens	212-218
28130415-1	2017	A sialidase NEU1 that removes sialic acids from glycoconjugates has been implicated in diverse cellular functions.	Sialic Acids	30-42	neuraminidase 1	Mus musculus	12-16
28786023-11	2017	When comparing the two NK cell subpopulations CD56bright and CD56dim, CD56bright NK cells had a higher amount of sialic acids on their surface compared to CD56dim NK cells regardless of body weight.	Sialic Acids	113-125	neural cell adhesion molecule 1	Homo sapiens	61-65
28554385-1	2017	Terminal sialic acids on N-glycan of recombinant human erythropoietin are very important for in vivo half-life, as this glycoprotein has three N-glycosylation sites.	Sialic Acids	9-21	erythropoietin	Homo sapiens	55-69
28701401-11	2017	H10 viruses preferentially bind "avian-like" sialic acids, although several isolates also displayed binding to "human-like" sialic acid receptors.	Sialic Acids	45-57	H1.0 linker histone	Homo sapiens	0-3
28505249-8	2017	Our data provide evidence of additional important function of sialic acids as a ROS scavenger in skeletal muscles, expanding our understanding on how sialic acid deficiency contributes to disease pathology, and identify oxidative stress as a therapeutic target in GNE myopathy.	Sialic Acids	62-74	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	264-267
27874015-6	2017	In addition to sialic acids, moDCs also expressed the sialic acid-binding immunoglobulin-like lectins (Siglecs) -3, -5, -7, -9 and -10, immune inhibitory receptors recognizing these sialic acids.	Sialic Acids	182-194	sialic acid binding Ig like lectin 5	Homo sapiens	54-134
28679431-5	2017	RESULTS: IgA1 O-glycans bore more sialic acids in patients with RA than in control subjects.	Sialic Acids	34-46	immunoglobulin heavy constant alpha 1	Homo sapiens	9-13
28395125-4	2017	In this study, we devised several approaches to investigate the donor specificity of the human beta-d-galactoside sialyltransferases ST6Gal I and ST3Gal I by using two CMP-sialic acids: CMP-Neu5Ac, and CMP-Neu5N-(4pentynoyl)neuraminic acid (CMP-SiaNAl), an unnatural CMP-sialic acid donor with an extended and functionalized N-acyl moiety.	Sialic Acids	172-184	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	133-141
28395125-4	2017	In this study, we devised several approaches to investigate the donor specificity of the human beta-d-galactoside sialyltransferases ST6Gal I and ST3Gal I by using two CMP-sialic acids: CMP-Neu5Ac, and CMP-Neu5N-(4pentynoyl)neuraminic acid (CMP-SiaNAl), an unnatural CMP-sialic acid donor with an extended and functionalized N-acyl moiety.	Sialic Acids	172-184	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	146-154
27899210-1	2017	Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids.	Sialic Acids	104-116	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	0-12
27899210-1	2017	Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids.	Sialic Acids	104-116	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	14-16
28359758-3	2017	In the peripheral lymphatics, extracellular vesicles are captured via their sialic acids by lymph node macrophages expressing the CD169 (sialoadhesin) molecule, thereby suppressing the immune response.	Sialic Acids	76-88	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	130-135
28359758-3	2017	In the peripheral lymphatics, extracellular vesicles are captured via their sialic acids by lymph node macrophages expressing the CD169 (sialoadhesin) molecule, thereby suppressing the immune response.	Sialic Acids	76-88	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	137-149
28757018-1	2017	Group A rotaviruses (RVAs) are divided into neuraminidase (NA)-sensitive and NA-insensitive strains depending upon their binding affinity to the VP8* domain in the terminal sialic acids (SAs) of cell surface carbohydrates.	Sialic Acids	173-185	neuraminidase 1	Bos taurus	44-57
28745640-0	2017	Determination of Sialic Acids in Liver and Milk Samples of Wild-type and CMAH Knock-out Mice.	Sialic Acids	17-29	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Mus musculus	73-77
28393207-5	2017	In addition, immunoprecipitation assays demonstrated that downregulation of ppGalNAc-T1 led to a reduction in the number of terminal alpha2,3 sialic acids on O-linked glycans of the matrix metalloproteinase-14 (MMP14) glycoprotein.	Sialic Acids	142-154	matrix metallopeptidase 14	Homo sapiens	182-209
27874015-7	2017	Treatment with Ac53FaxNeu5Ac abrogated putative cis and trans interactions between sialic acids and Siglec-7/-9.	Sialic Acids	83-95	sialic acid binding Ig like lectin 7	Homo sapiens	100-111
27874015-8	2017	Together, these data indicate that sialic acids limit the activation of moDCs via the TLR pathway, potentially by interacting with Siglec-7 or Siglec-9.	Sialic Acids	35-47	sialic acid binding Ig like lectin 7	Homo sapiens	131-139
27874015-8	2017	Together, these data indicate that sialic acids limit the activation of moDCs via the TLR pathway, potentially by interacting with Siglec-7 or Siglec-9.	Sialic Acids	35-47	sialic acid binding Ig like lectin 9	Homo sapiens	143-151
28096183-2	2017	The primary pneumococcal neuraminidase, NanA, which is a sialidase that catalyzes the cleavage of terminal sialic acids from host glycoconjugates, is involved in both of these processes.	Sialic Acids	107-119	neuraminidase 1	Homo sapiens	25-38
28069944-10	2017	Targeting sialic acids may be a general mechanism for pleiotropic actions of soluble klotho.	Sialic Acids	10-22	klotho	Mus musculus	85-91
28049733-2	2017	The major sialic acids in most mammalian tissues are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), the latter being derived from Neu5Ac via addition of one oxygen atom at the sugar nucleotide level by CMP-Neu5Ac hydroxylase (Cmah).	Sialic Acids	10-22	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	228-250
28049733-2	2017	The major sialic acids in most mammalian tissues are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), the latter being derived from Neu5Ac via addition of one oxygen atom at the sugar nucleotide level by CMP-Neu5Ac hydroxylase (Cmah).	Sialic Acids	10-22	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	252-256
27424943-4	2016	These two glycoproteins both recognize the sialic acid and have complementary activities, the HA binds the sialic acid through its receptor-binding site, the NA is a receptor-destroying enzyme that cleaves alpha2-3 and alpha2-6-linked sialic acids.	Sialic Acids	235-247	immunoglobulin binding protein 1	Homo sapiens	219-227
27825034-1	2017	We studied the ability of monoclonal Abs (mAbs) recognizing the major hemagglutinin (HA) antigenic sites to inhibit neuraminidase (NA) cleavage of sialic acids on fetuin.	Sialic Acids	147-159	neuraminidase 1	Homo sapiens	116-129
27917893-1	2016	Neuraminidase 1 (NEU1) is a lysosomal sialidase catalyzing the removal of terminal sialic acids from sialyloconjugates.	Sialic Acids	83-95	neuraminidase 1	Homo sapiens	0-15
27917893-1	2016	Neuraminidase 1 (NEU1) is a lysosomal sialidase catalyzing the removal of terminal sialic acids from sialyloconjugates.	Sialic Acids	83-95	neuraminidase 1	Homo sapiens	17-21
27584569-4	2016	ST3GAL sialyltransferases catalyze the transfer of sialic acids in the alpha2,3 linkage to termini of N- and O-glycans.	Sialic Acids	51-63	tumor-suppressor, HELA cell type	Homo sapiens	0-3
27704662-4	2016	Here, we investigated the expression of the genes encoding alpha2,3- and alpha2,6-galactoside sialyltransferases (ST3GAL1-6 and ST6GAL1-2) and the localization of sialic acids in the Fallopian tube of women with or without ectopic implantation.	Sialic Acids	163-175	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	128-137
27746785-0	2016	HA Antibody-Mediated FcgammaRIIIa Activity Is Both Dependent on FcR Engagement and Interactions between HA and Sialic Acids.	Sialic Acids	111-123	Fc gamma receptor IIIa	Homo sapiens	21-33
27746785-6	2016	However, the FcgammaRIIIa activation was inhibited when a mutant HA, unable to bind sialic acids, was used.	Sialic Acids	84-96	Fc gamma receptor IIIa	Homo sapiens	13-25
27448041-8	2016	CONCLUSION: Tobacco smoking has an influence on number of sialic acids residues in the transferrin and seems to change conversion of Tf isoforms, and this may disturb iron transport and in consequence influence on foetal development and nourishment.	Sialic Acids	58-70	transferrin	Homo sapiens	87-98
27893774-6	2016	By characterizing the Siglec-9-EC mutants, we could conclude that R120 in the V domain likely interacts with the terminal sialic acids of hAOC3 attached glycans whereas residues R284 and R290 in C22 are involved in the interactions with the active site channel of hAOC3.	Sialic Acids	122-134	sialic acid binding Ig like lectin 9	Homo sapiens	22-33
27893774-6	2016	By characterizing the Siglec-9-EC mutants, we could conclude that R120 in the V domain likely interacts with the terminal sialic acids of hAOC3 attached glycans whereas residues R284 and R290 in C22 are involved in the interactions with the active site channel of hAOC3.	Sialic Acids	122-134	amine oxidase copper containing 3	Homo sapiens	138-143
27393384-3	2016	The actual discrimination is performed by factor H, which has binding sites for polyanions (sialic acids, glycosaminoglycans, phospholipids).	Sialic Acids	92-104	complement factor H	Homo sapiens	42-50
26192491-3	2016	Elevated sialyltransferase activity leads to overexpression of cell surface sialic acids and contributes to many disease developments, such as cancer and inflammation.	Sialic Acids	76-88	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	9-26
27037841-1	2016	UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme for the biosynthesis of sialic acids.	Sialic Acids	111-123	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	64-67
31557988-8	2016	Furthermore, sialic acid-binding of red blood cells (RBC) could be inhibited with mAbs recognizing different epitopes and all mAb showed internalization of Sn.	Sialic Acids	13-24	sialic acid binding Ig like lectin 1	Homo sapiens	156-158
26647968-2	2016	Extracellular vesicles express membrane-bound sialic acids, which enable their capture by CD169 (sialoadhesin; Siglec-1) expressing macrophages in the lymph node and spleen.	Sialic Acids	46-58	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	90-95
26647968-2	2016	Extracellular vesicles express membrane-bound sialic acids, which enable their capture by CD169 (sialoadhesin; Siglec-1) expressing macrophages in the lymph node and spleen.	Sialic Acids	46-58	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	97-109
26647968-2	2016	Extracellular vesicles express membrane-bound sialic acids, which enable their capture by CD169 (sialoadhesin; Siglec-1) expressing macrophages in the lymph node and spleen.	Sialic Acids	46-58	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	111-119
27148485-4	2016	Differentially, humans express twenty different STs in a tissue-specific manner, each of which catalyzes the attachment of sialic acids via different glycosidic linkages (alpha2-3, alpha2-6, or alpha2-8) to the underlying glycan chain.	Sialic Acids	123-135	immunoglobulin binding protein 1	Homo sapiens	181-189
27148485-4	2016	Differentially, humans express twenty different STs in a tissue-specific manner, each of which catalyzes the attachment of sialic acids via different glycosidic linkages (alpha2-3, alpha2-6, or alpha2-8) to the underlying glycan chain.	Sialic Acids	123-135	immunoglobulin binding protein 1	Homo sapiens	194-202
26833330-8	2016	Metabolic labeling of sialic acids in fibroblasts confirmed deficient Golgi glycosylation, which was restored by lentiviral transduction with wild-type TMEM199.	Sialic Acids	22-34	transmembrane protein 199	Homo sapiens	152-159
26833332-9	2016	Abnormal N- and mucin type O-glycosylation was found on serum proteins, and reduced metabolic labeling of sialic acids was found in fibroblasts, which was restored after complementation with wild-type CCDC115.	Sialic Acids	106-118	coiled-coil domain containing 115	Homo sapiens	201-208
26411873-1	2016	UNLABELLED: Inhibitory CD33-related Siglec receptors regulate immune cell activation upon engaging ubiquitous sialic acids (Sias) on host cell surface glycans.	Sialic Acids	110-122	CD33 molecule	Homo sapiens	23-27
26829325-9	2016	Utilising peptide N-glycosidase-F and neuraminidase to remove N-glycans and sialic acids, respectively, we found that N-glycan composition (but not sialylation alone) were responsible for this reduction in molecular weight.	Sialic Acids	76-88	neuraminidase 1	Homo sapiens	38-51
26824057-4	2015	Cleavage of LAMP1 sialic acids by NEU1 limits the extent of lysosomal exocytosis.	Sialic Acids	18-30	lysosomal associated membrane protein 1	Homo sapiens	12-17
27063181-6	2016	An excellent source of sialic acids is edible bird nest substance (Collocalia mucin) which was used for the synthesis of sialylation inhibitors.	Sialic Acids	23-35	LOC100508689	Homo sapiens	78-83
28791106-5	2016	This method has been successfully used for in situ imaging of sialic acids on the target protein EpCAM on an MCF-7 cell surface and for the monitoring of the expression variation of protein-specific glycosylation during drug treatment.	Sialic Acids	62-74	epithelial cell adhesion molecule	Homo sapiens	97-102
26824057-4	2015	Cleavage of LAMP1 sialic acids by NEU1 limits the extent of lysosomal exocytosis.	Sialic Acids	18-30	neuraminidase 1	Homo sapiens	34-38
25552652-5	2015	In a novel SLC35A1-deficient cell model, we demonstrated a lack of alpha-DG O-mannosylation, ligand binding and incorporation of sialic acids.	Sialic Acids	129-141	solute carrier family 35 member A1	Homo sapiens	11-18
26370074-7	2015	MLV released from cells carrying N-acyl-modified sialic acids displayed strikingly different capacities for Siglec-1-mediated capture and trans-infection; N-butanoyl, N-isobutanoyl, N-glycolyl, or N-pentanoyl side chain modifications resulted in up to 92 and 80% reduction of virus particle capture and trans-infection, respectively, whereas N-propanoyl or N-cyclopropylcarbamyl side chains had no effect.	Sialic Acids	49-61	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	108-116
26092603-4	2015	Transferrin with two sialic acids (disialotransferrin) was fractionated from serum using HPLC, digested with trypsin, and evaluated using MALDI-TOF MS.	Sialic Acids	21-33	transferrin	Homo sapiens	0-11
25982064-9	2015	Consistent with this, TNSALP (P108L) acquired endo-beta-N-acetylglucosaminidase H resistance and sialic acids, as evidenced by glycosidase treatments.	Sialic Acids	97-109	alkaline phosphatase, biomineralization associated	Homo sapiens	22-28
26169044-0	2015	9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate.	Sialic Acids	19-31	CAS1 domain containing 1	Homo sapiens	48-53
25926653-5	2015	Pretreatment of RD cells with neuraminidase (NA) and trypsin greatly reduced the binding, suggesting that the binding was mediated by sialic acids on glycoproteins.	Sialic Acids	134-146	neuraminidase 1	Homo sapiens	30-43
25552652-6	2015	Removal of sialic acids from HAP1 wild-type cells after incorporation or preventing sialylation during synthesis did not affect alpha-DG O-mannosylation or ligand binding but did affect sialylation.	Sialic Acids	11-23	huntingtin associated protein 1	Homo sapiens	29-33
25754427-2	2015	Our objective was to investigate the expression level of the terminal alpha2-3- and alpha2-6-linked sialic acids in human saliva from type 2 diabetes mellitus (T2DM), liver disease and gastric cancer (GC) patients and assess the binding activity of these linked sialic acids against influenza A viruses (IAV).	Sialic Acids	100-112	immunoglobulin binding protein 1	Homo sapiens	84-92
25726973-6	2015	Mass spectrometric analysis (HPLC-ESI-MS/MS) of GP5 N-glycans revealed an abundance of N-acetylglucosamine (GlcNAc) and N-acetyllactosamine (LacNAc) oligomers in addition to sialic acids.	Sialic Acids	174-186	glycoprotein V platelet	Homo sapiens	48-51
25754427-2	2015	Our objective was to investigate the expression level of the terminal alpha2-3- and alpha2-6-linked sialic acids in human saliva from type 2 diabetes mellitus (T2DM), liver disease and gastric cancer (GC) patients and assess the binding activity of these linked sialic acids against influenza A viruses (IAV).	Sialic Acids	262-274	immunoglobulin binding protein 1	Homo sapiens	84-92
25754427-3	2015	We observed that the expression level of the terminal alpha2-3-linked sialic acids of elderly individuals with T2DM and liver disease were down-regulated significantly, and the terminal alpha2-6 linked sialic acids were up-regulated slightly or had no significant alteration.	Sialic Acids	202-214	immunoglobulin binding protein 1	Homo sapiens	186-194
25378396-3	2014	Secreted Klotho (sKL) up-regulates the TRPV5 calcium channel from the cell exterior by removing sialic acids from N-glycan of the channel and inhibiting its endocytosis.	Sialic Acids	96-108	klotho	Homo sapiens	9-15
25613425-5	2015	The important role of the sialosyl group of GM3 was demonstrated using NEU3, a plasma membrane-associated sialidase that selectively remove sialic acids from gangliosides GM3 and GD1a and is up-regulated in many human cancer cells.	Sialic Acids	140-152	neuraminidase 3	Homo sapiens	71-75
25575834-3	2015	Sialic acids play important roles in a variety of biological functions, such as development, recognition, and cell adhesion and are synthesized by conserved enzymatic pathways that include sialic acid synthase (SAS).	Sialic Acids	0-12	N-acetylneuraminate synthase	Homo sapiens	189-209
25575834-3	2015	Sialic acids play important roles in a variety of biological functions, such as development, recognition, and cell adhesion and are synthesized by conserved enzymatic pathways that include sialic acid synthase (SAS).	Sialic Acids	0-12	N-acetylneuraminate synthase	Homo sapiens	211-214
25494612-2	2015	Recent findings from our studies indicate that basal autophagy is required for the efficient lysosomal catabolism of sialyloligosaccharides, and that the downregulation of sialin, a lysosomal transporter of sialic acids can cause a significant delay in the cytosolic accumulation of such glycans.	Sialic Acids	207-219	solute carrier family 17 member 5	Homo sapiens	172-178
25033754-1	2015	Neuraminidase (NA) is the second most abundant influenza surface glycoprotein and contributes to virus replication in several ways, most notably by removing sialic acids from the host and viral glycoproteins, releasing newly formed virus particles from infected cells.	Sialic Acids	157-169	neuraminidase 1	Homo sapiens	0-13
26640816-11	2015	Moreover, a neuraminidase (sialidase), a component of the viral envelope of Newcastle Disease, Mumps, and Sendai viruses, can cleave sialic acids on the surface of malignant cells thereby unmasking cancer antigens and exposing them to the immune system.	Sialic Acids	133-145	neuraminidase 1	Homo sapiens	12-25
24276958-2	2015	MAG binds with high preference to sialic acids alpha(2-3)-linked to D-galactose.	Sialic Acids	34-46	myelin associated glycoprotein	Homo sapiens	0-3
25378396-3	2014	Secreted Klotho (sKL) up-regulates the TRPV5 calcium channel from the cell exterior by removing sialic acids from N-glycan of the channel and inhibiting its endocytosis.	Sialic Acids	96-108	transient receptor potential cation channel subfamily V member 5	Homo sapiens	39-44
24255917-2	2014	We determined that sialoadhesin (CD169; Siglec-1) is required for the capture of B cell-derived exosomes via their surface-expressed alpha2,3-linked sialic acids.	Sialic Acids	149-161	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	19-31
25008942-5	2014	In support of this structural observation, interactions of VP1 with alpha2,3- and alpha2,6-linked sialic acids could not be detected in solution by nuclear magnetic resonance spectroscopy.	Sialic Acids	98-110	VP1	Human polyomavirus 6	59-62
24966944-11	2014	The presence of sialic acids on tumor cell surface can be an indicative of poor prognosis and our study provides further evidence that SNA lectin can be used as a prognostic probe in IDC and DCIS patients.	Sialic Acids	16-28	snail family transcriptional repressor 1	Homo sapiens	135-138
24377426-3	2014	Birds and humans have alpha2-3 and alpha2-6 linked sialic acids, respectively.	Sialic Acids	51-63	immunoglobulin binding protein 1	Homo sapiens	35-43
24255917-2	2014	We determined that sialoadhesin (CD169; Siglec-1) is required for the capture of B cell-derived exosomes via their surface-expressed alpha2,3-linked sialic acids.	Sialic Acids	149-161	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	33-38
25116630-0	2014	Terminal sialic acids on CD44 N-glycans can block hyaluronan binding by forming competing intramolecular contacts with arginine sidechains.	Sialic Acids	9-21	CD44 molecule (Indian blood group)	Homo sapiens	25-29
25225409-1	2014	Certain pathogenic bacteria are known to modulate the innate immune response by decorating themselves with sialic acids, which can engage the myelomonocytic lineage inhibitory receptor Siglec-9, thereby evading immunosurveillance.	Sialic Acids	107-119	sialic acid binding Ig-like lectin E	Mus musculus	185-193
25002414-2	2014	Genetic approaches have provided evidence that this inhibition of B-cell antigen receptor (BCR) signaling by Siglecs is dependent on ligand binding to sialic acids in specific linkages.	Sialic Acids	151-163	BCR activator of RhoGEF and GTPase	Homo sapiens	66-89
25002414-2	2014	Genetic approaches have provided evidence that this inhibition of B-cell antigen receptor (BCR) signaling by Siglecs is dependent on ligand binding to sialic acids in specific linkages.	Sialic Acids	151-163	BCR activator of RhoGEF and GTPase	Homo sapiens	91-94
24578376-7	2014	The removal of sialic acids by neuraminidase induces iPS-MBMC and hES cells differentiation, prompting an ectoderm commitment.	Sialic Acids	15-27	neuraminidase 1	Homo sapiens	31-44
24255917-2	2014	We determined that sialoadhesin (CD169; Siglec-1) is required for the capture of B cell-derived exosomes via their surface-expressed alpha2,3-linked sialic acids.	Sialic Acids	149-161	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	40-48
25566667-2	2014	Moreover, we also investigated the type of sialic acids binding with its glycans using sialospecific lectins MAA and SNA.	Sialic Acids	43-55	snail family transcriptional repressor 1	Homo sapiens	117-120
24076232-4	2014	METHODS: RBCs are treated with neuraminidase to specifically remove sialic acids from their surface followed by the evaluation of their deformability, zeta potential and membrane proteins.	Sialic Acids	68-80	neuraminidase 1	Homo sapiens	31-44
23880766-5	2013	Moreover, knockdown of sialin, a lysosomal transporter of sialic acids, resulted in a significant reduction of sialyloligosaccharides, implying that autophagy affects the substrate specificity of this transporter.	Sialic Acids	58-70	solute carrier family 17 member 5	Homo sapiens	23-29
24349002-3	2013	The key enzyme of sialic acid biosynthesis is the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), which catalyses the first two steps of Sia biosynthesis in the cytosol.	Sialic Acids	172-175	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	127-130
24261589-0	2013	Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase.	Sialic Acids	46-58	neuraminidase 1	Homo sapiens	64-77
24261589-1	2013	BACKGROUND: Influenza A virus (IAV) neuraminidase (NA) cleaves sialic acids (Sias) from glycans.	Sialic Acids	63-75	neuraminidase 1	Homo sapiens	36-49
24261589-1	2013	BACKGROUND: Influenza A virus (IAV) neuraminidase (NA) cleaves sialic acids (Sias) from glycans.	Sialic Acids	77-81	neuraminidase 1	Homo sapiens	36-49
24307735-3	2014	Previous studies demonstrated that PTX3 and the short pentraxin serum amyloid P express sialic acids that are recognized by the hemagglutinin (HA) glycoprotein of certain influenza A viruses (IAV), resulting in virus neutralization and anti-IAV activity.	Sialic Acids	88-100	pentraxin related gene	Mus musculus	35-39
23519810-1	2013	The enzyme N-acetylneuraminate lyase (EC 4.1.3.3) is involved in the metabolism of sialic acids.	Sialic Acids	83-95	AT695_RS02220	Staphylococcus aureus	11-36
23535562-1	2013	A series of STn-MUC1 and ST-MUC1 glycopeptides containing naturally occurring and non-natural sialic acids have been chemoenzymatically synthesized from Tn-MUC1 glycopeptide using one-pot multienzyme (OPME) approaches.	Sialic Acids	94-106	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	12-15
23535562-1	2013	A series of STn-MUC1 and ST-MUC1 glycopeptides containing naturally occurring and non-natural sialic acids have been chemoenzymatically synthesized from Tn-MUC1 glycopeptide using one-pot multienzyme (OPME) approaches.	Sialic Acids	94-106	mucin 1, cell surface associated	Homo sapiens	16-20
23535562-1	2013	A series of STn-MUC1 and ST-MUC1 glycopeptides containing naturally occurring and non-natural sialic acids have been chemoenzymatically synthesized from Tn-MUC1 glycopeptide using one-pot multienzyme (OPME) approaches.	Sialic Acids	94-106	mucin 1, cell surface associated	Homo sapiens	28-32
23535562-1	2013	A series of STn-MUC1 and ST-MUC1 glycopeptides containing naturally occurring and non-natural sialic acids have been chemoenzymatically synthesized from Tn-MUC1 glycopeptide using one-pot multienzyme (OPME) approaches.	Sialic Acids	94-106	mucin 1, cell surface associated	Homo sapiens	28-32
23836650-3	2013	With its extracellular domain, CD22 binds to sialic acids in alpha2,6 linkages in cis, on the surface of the same B cell or in trans, on other cells.	Sialic Acids	45-57	CD22 antigen	Mus musculus	31-35
23161284-10	2013	Collectively, these results demonstrate that CXCL14 binding to glycoproteins harboring heparan sulfate proteoglycans and sialic acids leads proliferation and migration of some cancer cells.	Sialic Acids	121-133	C-X-C motif chemokine ligand 14	Homo sapiens	45-51
23363739-1	2013	Human sialidase 2 (NEU2) is a cytoplasmic sialidase that degrades sialylglycoconjugates, including glycoproteins and gangliosides, via hydrolysis of terminal sialic acids to produce asialo-type molecules.	Sialic Acids	158-170	neuraminidase 2	Homo sapiens	6-17
23363739-1	2013	Human sialidase 2 (NEU2) is a cytoplasmic sialidase that degrades sialylglycoconjugates, including glycoproteins and gangliosides, via hydrolysis of terminal sialic acids to produce asialo-type molecules.	Sialic Acids	158-170	neuraminidase 2	Homo sapiens	19-23
23708432-7	2013	Each EPO product showed a characteristic glycoform profile with respect to sialylation, glycan size, O-acetylation of sialic acids and O-glycosylation.	Sialic Acids	118-130	erythropoietin	Homo sapiens	5-8
23462539-10	2013	Hu-recA1PI contained both alpha(2-3)- and alpha(2-6)-linked sialic acids and had very similar sialylation levels as pd-A1PI.	Sialic Acids	60-72	serpin family A member 1	Homo sapiens	6-10
23139156-0	2013	Channel sialic acids limit hERG channel activity during the ventricular action potential.	Sialic Acids	8-20	ETS transcription factor ERG	Homo sapiens	27-31
23298785-4	2013	In the present study, we investigated the expression profile of ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 (ST8Sia VI) in the suprachiasmatic nucleus (SCN), which is one of the modification transferases that add sialic acids to type O carbohydrate chains.	Sialic Acids	230-242	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	Homo sapiens	64-124
23298785-4	2013	In the present study, we investigated the expression profile of ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 (ST8Sia VI) in the suprachiasmatic nucleus (SCN), which is one of the modification transferases that add sialic acids to type O carbohydrate chains.	Sialic Acids	230-242	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	Homo sapiens	126-135
23727924-1	2013	Mammalian sialidases (NEU1, NEU2, NEU3 and NEU4) that remove sialic acids from glycoconjugates have been implicated in diverse cellular functions.	Sialic Acids	61-73	neuraminidase 1	Mus musculus	22-26
23035012-6	2013	The enhanced TGF-beta production required a direct interaction between the two cell lines through sialic acids.	Sialic Acids	98-110	transforming growth factor beta 1	Homo sapiens	13-21
23727924-1	2013	Mammalian sialidases (NEU1, NEU2, NEU3 and NEU4) that remove sialic acids from glycoconjugates have been implicated in diverse cellular functions.	Sialic Acids	61-73	neuraminidase 2	Mus musculus	28-32
23727924-1	2013	Mammalian sialidases (NEU1, NEU2, NEU3 and NEU4) that remove sialic acids from glycoconjugates have been implicated in diverse cellular functions.	Sialic Acids	61-73	neuraminidase 3	Mus musculus	34-38
23727924-1	2013	Mammalian sialidases (NEU1, NEU2, NEU3 and NEU4) that remove sialic acids from glycoconjugates have been implicated in diverse cellular functions.	Sialic Acids	61-73	sialidase 4	Mus musculus	43-47
22987365-0	2012	The impact of sialic acids on the pharmacokinetics of a PEGylated erythropoietin.	Sialic Acids	14-26	erythropoietin	Homo sapiens	66-80
22901108-2	2012	Derivatization of the sialic acids with 2-aminoacridone (2-AMAC), using classical reductive amination in a nonaqueous solvent, led to the spontaneous decarboxylation of the sialic acid residues as determined by CE-LIF and offline mass spectrometric analysis.	Sialic Acids	22-34	solute carrier family 35 member G5	Homo sapiens	59-63
22853823-3	2012	RESULTS: We demonstrated that the attachment of EV71 to RD and SK-N-SH cells was diminished after the removal of cell surface sialic acids by neuraminidase.	Sialic Acids	126-138	neuraminidase 1	Homo sapiens	142-155
22542522-2	2012	It is built as a homopolymer of up to 150 molecules of alpha 2-8-linked sialic acids on N-glycans of the fifth immunoglobulin-like domain of NCAM.	Sialic Acids	72-84	neural cell adhesion molecule 1	Homo sapiens	141-145
22093819-1	2011	Human plasma membrane-associated sialidase (Neu3) is one of several sialidases that hydrolyze sialic acids in the terminal position of the carbohydrate groups of glycolipids and glycoproteins.	Sialic Acids	94-106	neuraminidase 3	Homo sapiens	13-48
22665810-7	2012	Chimpanzee Siglec-13 and the resurrected human Siglec-17 recruit a signaling adapter and bind sialic acids.	Sialic Acids	94-106	sialic acid-binding Ig-like lectin 13	Pan troglodytes	11-20
22449099-1	2012	BACKGROUND: Previously, we found that beta-galactoside alpha2,6-sialyltransferase (ST6Gal I), an enzyme that adds sialic acids to N-linked oligosaccharides of glycoproteins and is frequently overexpressed in cancer cells, is up-regulated by ionizing radiation (IR) and cleaved to a form possessing catalytic activity comparable to that of the Golgi-localized enzyme.	Sialic Acids	114-126	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	83-91
22396165-4	2012	Removal of terminal sialic acids from N-glycan chains of the epithelial Ca(2+) channel TRPV5 and the renal K(+) channel ROMK by secreted Klotho exposes the underlying disaccharide galactose-N-acetylglucosamine, a ligand for galectin-1.	Sialic Acids	20-32	transient receptor potential cation channel subfamily V member 5	Homo sapiens	87-92
22396165-4	2012	Removal of terminal sialic acids from N-glycan chains of the epithelial Ca(2+) channel TRPV5 and the renal K(+) channel ROMK by secreted Klotho exposes the underlying disaccharide galactose-N-acetylglucosamine, a ligand for galectin-1.	Sialic Acids	20-32	klotho	Homo sapiens	137-143
22396165-4	2012	Removal of terminal sialic acids from N-glycan chains of the epithelial Ca(2+) channel TRPV5 and the renal K(+) channel ROMK by secreted Klotho exposes the underlying disaccharide galactose-N-acetylglucosamine, a ligand for galectin-1.	Sialic Acids	20-32	galectin 1	Homo sapiens	224-234
21803834-0	2012	Regulation of O-acetylation of sialic acids by sialate-O-acetyltransferase and sialate-O-acetylesterase activities in childhood acute lymphoblastic leukemia.	Sialic Acids	31-43	sterol O-acyltransferase 1	Homo sapiens	47-74
21803834-0	2012	Regulation of O-acetylation of sialic acids by sialate-O-acetyltransferase and sialate-O-acetylesterase activities in childhood acute lymphoblastic leukemia.	Sialic Acids	31-43	sialic acid acetylesterase	Homo sapiens	79-103
21803834-2	2012	Sialate-O-acetyltransferase (SOAT) and sialate-O-acetylesterase (SIAE) are the two main enzymes responsible for the quantity of the O-acetyl ester groups on sialic acids (Sias).	Sialic Acids	157-169	sterol O-acyltransferase 1	Homo sapiens	0-27
21803834-2	2012	Sialate-O-acetyltransferase (SOAT) and sialate-O-acetylesterase (SIAE) are the two main enzymes responsible for the quantity of the O-acetyl ester groups on sialic acids (Sias).	Sialic Acids	157-169	sterol O-acyltransferase 1	Homo sapiens	29-33
21803834-2	2012	Sialate-O-acetyltransferase (SOAT) and sialate-O-acetylesterase (SIAE) are the two main enzymes responsible for the quantity of the O-acetyl ester groups on sialic acids (Sias).	Sialic Acids	157-169	sialic acid acetylesterase	Homo sapiens	39-63
21803834-2	2012	Sialate-O-acetyltransferase (SOAT) and sialate-O-acetylesterase (SIAE) are the two main enzymes responsible for the quantity of the O-acetyl ester groups on sialic acids (Sias).	Sialic Acids	157-169	sialic acid acetylesterase	Homo sapiens	65-69
22575822-7	2012	These results suggest that Cheongja 3 black soybean seed coat anthocyanins have brain neuroprotective effects against oxidative stress (H(2)O(2)) by inhibiting the activation of ASK1-JNK/p38 pathways, scavenging ROS, stimulating the expression of HO-1 and, more interestingly, recruiting cellular free sialic acids through up-regulation of Neu1 sialidase gene expression.	Sialic Acids	302-314	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	178-182
22575822-7	2012	These results suggest that Cheongja 3 black soybean seed coat anthocyanins have brain neuroprotective effects against oxidative stress (H(2)O(2)) by inhibiting the activation of ASK1-JNK/p38 pathways, scavenging ROS, stimulating the expression of HO-1 and, more interestingly, recruiting cellular free sialic acids through up-regulation of Neu1 sialidase gene expression.	Sialic Acids	302-314	mitogen-activated protein kinase 8	Homo sapiens	183-186
22408387-9	2012	The multiple spots detected for cerebrospinal fluid transferrin were mainly due to heterogeneity of di-antennary and tri-antennary glycans harboring a varying number of terminal N-acetylneuraminic acids and the existence of a high mannose and high N-acetylhexosamine glycosylated species.	Sialic Acids	178-202	transferrin	Homo sapiens	52-63
22377735-1	2012	This study was aimed at obtaining insight into the diversity of sialic acids in cancer- and non-cancer-related CA125 antigen, tumour marker of serous ovarian cancer.	Sialic Acids	64-76	mucin 16, cell surface associated	Homo sapiens	111-116
22152306-6	2011	In addition, neuraminidase treatment of apoC-III which removes the sialic acids from its glycan chain decreases its potential to inhibit LPL.	Sialic Acids	67-79	neuraminidase 1	Homo sapiens	13-26
22152306-6	2011	In addition, neuraminidase treatment of apoC-III which removes the sialic acids from its glycan chain decreases its potential to inhibit LPL.	Sialic Acids	67-79	apolipoprotein C3	Homo sapiens	40-48
22152306-6	2011	In addition, neuraminidase treatment of apoC-III which removes the sialic acids from its glycan chain decreases its potential to inhibit LPL.	Sialic Acids	67-79	lipoprotein lipase	Homo sapiens	137-140
22243251-11	2011	We conclude that pig KLK4 has NA2, NA2F, and NA3 N-glycan cores with no, or with one, two, or three sialic acids.	Sialic Acids	100-112	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	Mus musculus	21-25
22243251-12	2011	Mouse KLK4 has NA2, NA2F, and NA3F N-glycan cores with no, or with one or two sialic acids.	Sialic Acids	78-90	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	Mus musculus	6-10
21919466-11	2011	They also provide the strongest proof to date that DmSAS is a key enzyme in the biosynthesis of sialic acids in Dm CNS neurons, and the observed subcellular distribution of the newly synthesized sialic acids offers insights into their biological function.	Sialic Acids	96-108	N-acetylneuraminic acid synthase	Drosophila melanogaster	51-56
21945320-0	2011	Biochemical engineering of the N-acyl side chain of sialic acids alters the kinetics of a glycosylated potassium channel Kv3.1.	Sialic Acids	52-64	potassium voltage-gated channel subfamily C member 1	Homo sapiens	121-126
21604388-5	2011	RESULTS: Sialic acids were found in LPS, Pla-protease, allergen pestin PP, and all cholera O-AG; their absence was demonstrated in MSA and F1.	Sialic Acids	9-21	plasminogen activator protease precursor	Yersinia pestis	41-44
21690238-9	2011	In vitro studies demonstrated that GBS sialic acids participate in the suppression of murine polymorphonuclear leukocyte (PMN) bactericidal activities, in addition to reducing levels of IL-1alpha, tumor necrosis factor alpha, IL-1beta, MIP-1alpha, and KC produced by PMNs.	Sialic Acids	39-51	interleukin 1 alpha	Mus musculus	186-195
21690238-9	2011	In vitro studies demonstrated that GBS sialic acids participate in the suppression of murine polymorphonuclear leukocyte (PMN) bactericidal activities, in addition to reducing levels of IL-1alpha, tumor necrosis factor alpha, IL-1beta, MIP-1alpha, and KC produced by PMNs.	Sialic Acids	39-51	tumor necrosis factor	Mus musculus	197-224
21690238-9	2011	In vitro studies demonstrated that GBS sialic acids participate in the suppression of murine polymorphonuclear leukocyte (PMN) bactericidal activities, in addition to reducing levels of IL-1alpha, tumor necrosis factor alpha, IL-1beta, MIP-1alpha, and KC produced by PMNs.	Sialic Acids	39-51	interleukin 1 beta	Mus musculus	226-234
21690238-9	2011	In vitro studies demonstrated that GBS sialic acids participate in the suppression of murine polymorphonuclear leukocyte (PMN) bactericidal activities, in addition to reducing levels of IL-1alpha, tumor necrosis factor alpha, IL-1beta, MIP-1alpha, and KC produced by PMNs.	Sialic Acids	39-51	chemokine (C-C motif) ligand 3	Mus musculus	236-246
21606496-5	2011	In contrast, sialylation of 2B4 has a negative impact on ligand binding, as the interaction between 2B4 and CD48 is increased after the removal of sialic acids.	Sialic Acids	147-159	CD244 molecule	Homo sapiens	28-31
21606496-5	2011	In contrast, sialylation of 2B4 has a negative impact on ligand binding, as the interaction between 2B4 and CD48 is increased after the removal of sialic acids.	Sialic Acids	147-159	CD244 molecule	Homo sapiens	100-103
21606496-5	2011	In contrast, sialylation of 2B4 has a negative impact on ligand binding, as the interaction between 2B4 and CD48 is increased after the removal of sialic acids.	Sialic Acids	147-159	CD48 molecule	Homo sapiens	108-112
21464904-8	2011	Our data also show that the sialic acids exposed on the erythrocyte membrane contribute for the interaction with fibrinogen, possibly by facilitating its binding to the erythrocyte membrane receptor.	Sialic Acids	28-40	fibrinogen beta chain	Homo sapiens	113-123
20711574-5	2010	The surface-displayed recombinant NanH protein was expressed as a fully active sialidase and also transferred sialic acids from pNP-alpha-sialoside, a sialic acid donor substrate, to human-type asialo-N-glycans.	Sialic Acids	110-122	neuraminidase 1	Homo sapiens	34-38
21285368-2	2011	It is unresolved how host and nonhost surfaces are distinguished at the molecular level, but key components are domains 19-20 of the complement regulator factor H (FH), which interact with host (i.e., nonactivator surface glycosaminoglycans or sialic acids) and the C3d part of C3b.	Sialic Acids	244-256	complement factor H	Homo sapiens	154-162
21285368-2	2011	It is unresolved how host and nonhost surfaces are distinguished at the molecular level, but key components are domains 19-20 of the complement regulator factor H (FH), which interact with host (i.e., nonactivator surface glycosaminoglycans or sialic acids) and the C3d part of C3b.	Sialic Acids	244-256	complement factor H	Homo sapiens	164-166
20739279-10	2010	The modification of SynCAM 1 with sialic acids contributes to the glycan-dependent strengthening of its binding.	Sialic Acids	34-46	cell adhesion molecule 1	Homo sapiens	20-28
20711574-6	2010	Moreover, this system was capable of attaching sialic acids to the glycans of asialofetuin via alpha(2,3)- or alpha(2,6)-linkage.	Sialic Acids	47-59	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	95-104
20711574-6	2010	Moreover, this system was capable of attaching sialic acids to the glycans of asialofetuin via alpha(2,3)- or alpha(2,6)-linkage.	Sialic Acids	47-59	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	110-119
20711574-7	2010	The cell surface-expressed C. diphtheriae sialidase showed its potential as a useful whole cell biocatalyst for the transfer of sialic acid as well as the hydrolysis of N-glycans containing alpha(2,3)- and alpha(2,6)-linked sialic acids for glycoprotein remodeling.	Sialic Acids	224-236	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	190-199
20711574-7	2010	The cell surface-expressed C. diphtheriae sialidase showed its potential as a useful whole cell biocatalyst for the transfer of sialic acid as well as the hydrolysis of N-glycans containing alpha(2,3)- and alpha(2,6)-linked sialic acids for glycoprotein remodeling.	Sialic Acids	224-236	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	206-215
20826457-7	2010	Cleavage by neuraminidase of sialic acids, as well as lectin binding to sialic acids on the surfaces, enhanced the engulfment of apoptotic cells and blebs.	Sialic Acids	29-41	neuraminidase 1	Homo sapiens	12-25
20721346-6	2010	Moreover, microglial neurotoxicity is alleviated via interaction of Siglec-11 with sialic acids on the neuronal glycocalyx.	Sialic Acids	83-95	sialic acid binding Ig like lectin 11	Homo sapiens	68-77
20587060-12	2010	If the cells were treated with neuraminidase to remove cis-acting sialic acids that hinder the interaction of the virus with Sn, the amount of infected cells with macrophage grown virus increased.	Sialic Acids	66-78	neuraminidase 1	Homo sapiens	31-44
20534525-4	2010	MAG inhibition of axon outgrowth in some neurons is reversed by treatment with sialidase, an enzyme that hydrolyzes sialic acids and eliminates MAG-sialoglycan binding.	Sialic Acids	116-128	myelin-associated glycoprotein	Rattus norvegicus	0-3
20085901-5	2010	K27, JISH118, L280 and MON29 were categorized as high SA-containing strains having enhanced 9-O-acetyl sialic acid (9-O-AcSA(high)) whereas LV4 and LV81 evidenced considerably reduced SA.	Sialic Acids	54-56	acyl-CoA synthetase short chain family member 2	Homo sapiens	120-124
20348402-9	2010	The O-glycans on pro-BNP had sialic acids at their termini, protecting it from O-glycosidase digestion.	Sialic Acids	29-41	natriuretic peptide B	Homo sapiens	21-24
20172905-4	2010	We conducted a proteomics scale study to identify candidate trans ligands of CD22 on B-cells by UV photocross-linking CD22-Fc chimera bound to B-cell glycoproteins engineered to carry sialic acids with a 9-aryl azide moiety.	Sialic Acids	184-196	CD22 molecule	Homo sapiens	77-81
20172905-4	2010	We conducted a proteomics scale study to identify candidate trans ligands of CD22 on B-cells by UV photocross-linking CD22-Fc chimera bound to B-cell glycoproteins engineered to carry sialic acids with a 9-aryl azide moiety.	Sialic Acids	184-196	CD22 molecule	Homo sapiens	118-122
20438083-3	2010	We report here that replacement of sialic acids on cell surfaces with fluorinated congeners dramatically decreases cell adhesion to E- and P-selectin-coated surfaces.	Sialic Acids	35-47	selectin P	Homo sapiens	139-149
19947630-0	2009	Chemoenzymatic synthesis of GD3 oligosaccharides and other disialyl glycans containing natural and non-natural sialic acids.	Sialic Acids	111-123	GRDX	Homo sapiens	28-31
20436925-8	2010	Treatment of neurons with sialidase, an enzyme that cleaves the terminal sialic acids required for MAG binding, reversed MAG"s protective effect, as did treatment with (1R,2R)-1-phenyl-2-hexadecanoylamino-3-pyrrolidino-1-propanol, an inhibitor of glycosphingolipid biosynthesis.	Sialic Acids	73-85	myelin-associated glycoprotein	Mus musculus	121-124
19800998-9	2010	Importantly, a considerable shift towards alpha-2,3-linked sialic acids and alpha-2,3-specific SiaT mRNA levels occurred in primary chondrocytes treated with IL-1beta or tumour necrosis factor-alpha (TNF-alpha).	Sialic Acids	59-71	interleukin 1 beta	Homo sapiens	158-166
19800998-9	2010	Importantly, a considerable shift towards alpha-2,3-linked sialic acids and alpha-2,3-specific SiaT mRNA levels occurred in primary chondrocytes treated with IL-1beta or tumour necrosis factor-alpha (TNF-alpha).	Sialic Acids	59-71	tumor necrosis factor	Homo sapiens	200-209
19947630-1	2009	In order to understand the biological importance of naturally occurring sialic acid variations on disialyl structures in nature, we developed an efficient two-step multienzyme approach for the synthesis of a series of GD3 ganglioside oligosaccharides and other disialyl glycans containing a terminal Siaalpha2-8Sia component with different natural and non-natural sialic acids.	Sialic Acids	364-376	GRDX	Homo sapiens	218-221
19630432-2	2009	Advantages of this newly developed synthesis include the use of economically available materials and reagents, the ease of operations and the excellent control of stereochemistry, as well as the convenience in application to the C-4 modifications of sialic acids.	Sialic Acids	250-262	complement C4A (Rodgers blood group)	Homo sapiens	229-232
19735140-7	2009	Neuraminidase action leads to an important decrease in the interphase charge density by removing sialic acids from the cell soft surface layer.	Sialic Acids	97-109	neuraminidase 1	Homo sapiens	0-13
19630432-0	2009	Efficient synthesis of 4-amido-N(5)-acetyl-4-deoxyneuraminic acid and its application to the C-4 modification of sialic acids.	Sialic Acids	113-125	complement C4A (Rodgers blood group)	Homo sapiens	93-96
19349416-6	2009	Here, we report that KLe treatment increases the cell-membrane abundance of the renal K(+) channel renal outer medullary potassium channel 1 (ROMK1) by removing terminal sialic acids from N-glycan of the channel.	Sialic Acids	170-182	potassium voltage-gated channel subfamily A member 5	Homo sapiens	121-140
19426133-1	2009	The key enzyme for the biosynthesis of N-acetylneuraminic acid, from which all other sialic acids are formed, is the bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).	Sialic Acids	85-97	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	137-199
19426133-1	2009	The key enzyme for the biosynthesis of N-acetylneuraminic acid, from which all other sialic acids are formed, is the bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).	Sialic Acids	85-97	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	201-204
19361277-3	2009	Sialic acids are synthesized in the cytosol starting from UDP-N-acetylglucosamine by the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE), which is the key enzyme in the biosynthesis of sialic acid that catalyzes the generation of N-acetylmannosamine, which in turn is an intermediate of the sialic acid pathway that represents the natural molecular precursor of all sialic acids.	Sialic Acids	0-12	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	89-151
19361277-3	2009	Sialic acids are synthesized in the cytosol starting from UDP-N-acetylglucosamine by the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE), which is the key enzyme in the biosynthesis of sialic acid that catalyzes the generation of N-acetylmannosamine, which in turn is an intermediate of the sialic acid pathway that represents the natural molecular precursor of all sialic acids.	Sialic Acids	0-12	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	153-156
19361277-3	2009	Sialic acids are synthesized in the cytosol starting from UDP-N-acetylglucosamine by the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE), which is the key enzyme in the biosynthesis of sialic acid that catalyzes the generation of N-acetylmannosamine, which in turn is an intermediate of the sialic acid pathway that represents the natural molecular precursor of all sialic acids.	Sialic Acids	387-399	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	89-151
19361277-3	2009	Sialic acids are synthesized in the cytosol starting from UDP-N-acetylglucosamine by the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE), which is the key enzyme in the biosynthesis of sialic acid that catalyzes the generation of N-acetylmannosamine, which in turn is an intermediate of the sialic acid pathway that represents the natural molecular precursor of all sialic acids.	Sialic Acids	387-399	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	153-156
19594633-4	2009	CD22 interacts specifically with ligands carrying alpha2-6-linked sialic acids.	Sialic Acids	66-78	CD22 molecule	Homo sapiens	0-4
19349416-6	2009	Here, we report that KLe treatment increases the cell-membrane abundance of the renal K(+) channel renal outer medullary potassium channel 1 (ROMK1) by removing terminal sialic acids from N-glycan of the channel.	Sialic Acids	170-182	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	142-147
19349416-7	2009	Removal of sialic acids exposes underlying disaccharide galactose-N-acetylglucosamine, a ligand for a ubiquitous galactoside-binding lectin galectin-1.	Sialic Acids	11-23	galectin 1	Homo sapiens	140-150
18815882-1	2009	The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme for the biosynthesis of sialic acids, terminal components of glycoconjugates associated with a variety of physiological and pathological processes.	Sialic Acids	135-147	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	24-86
19572026-7	2009	Quantitation of sialic acids released from the cellular membranes demonstrated that the presence of the DeltaF508 CFTR is associated with markedly decreased membrane sialylation, but similar cytoplasmic sialylation.	Sialic Acids	16-28	CF transmembrane conductance regulator	Homo sapiens	114-118
18815882-1	2009	The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme for the biosynthesis of sialic acids, terminal components of glycoconjugates associated with a variety of physiological and pathological processes.	Sialic Acids	135-147	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	88-91
19084340-3	2009	Glycophorin A (GPA), which is a major carrier of the sialic acids on RBCs, is a possible invasive receptor for Babesia parasites.	Sialic Acids	53-65	glycophorin A	Mus musculus	15-18
19714866-1	2009	BACKGROUND: Neuraminidase-1 (NEU1) catabolizes the hydrolysis of sialic acids from sialo-glycoconjugates.	Sialic Acids	65-77	neuraminidase 1	Homo sapiens	12-27
19714866-1	2009	BACKGROUND: Neuraminidase-1 (NEU1) catabolizes the hydrolysis of sialic acids from sialo-glycoconjugates.	Sialic Acids	65-77	neuraminidase 1	Homo sapiens	29-33
18788072-5	2009	Sialic acids were in both alpha2-3 and alpha2-6 linkage as determined by MALDI-TOF MS following linkage-specific derivatization.	Sialic Acids	0-12	immunoglobulin binding protein 1	Homo sapiens	39-47
18703050-5	2008	Correspondingly, collagen binding is reduced by enzymatic removal of cell surface sialic acids from ras-expressors with high ST6Gal-I levels (i.e., no shRNA).	Sialic Acids	82-94	beta galactoside alpha 2,6 sialyltransferase 1	Mus musculus	125-133
18708363-8	2008	However, removal of sialic acids by neuraminidase 2 or knockdown of expression by short interfering RNA targeting ST6Gal I restored radiation-induced cell death phenotypes.	Sialic Acids	20-32	neuraminidase 2	Homo sapiens	36-51
18384747-1	2008	Sialidase Neu2 is an exoglycosidase that removes terminal sialic acids from glycolipids and glycoproteins.	Sialic Acids	58-70	neuraminidase 2	Homo sapiens	10-14
18606998-6	2008	Here, we report that the extracellular domain of Klotho activates plasma-membrane resident TRPV5 through removing terminal sialic acids from their glycan chains.	Sialic Acids	123-135	klotho	Homo sapiens	49-55
18606998-6	2008	Here, we report that the extracellular domain of Klotho activates plasma-membrane resident TRPV5 through removing terminal sialic acids from their glycan chains.	Sialic Acids	123-135	transient receptor potential cation channel subfamily V member 5	Homo sapiens	91-96
18606998-7	2008	Removal of sialic acids exposes underlying disaccharide galactose-N-acetylglucosamine, a ligand for a ubiquitous galactoside-binding lectin galectin-1.	Sialic Acids	11-23	galectin 1	Homo sapiens	140-150
18606142-3	2008	Here we show that neuraminidase NEU1 negatively regulates lysosomal exocytosis in hematopoietic cells by processing the sialic acids on the lysosomal membrane protein LAMP-1.	Sialic Acids	120-132	neuraminidase 1	Mus musculus	32-36
18606142-3	2008	Here we show that neuraminidase NEU1 negatively regulates lysosomal exocytosis in hematopoietic cells by processing the sialic acids on the lysosomal membrane protein LAMP-1.	Sialic Acids	120-132	lysosomal-associated membrane protein 1	Mus musculus	167-173
17651898-5	2007	Flow cytometric analysis showed a remarkable reduction of Maackia amurensis lectin II binding to the surface of GPA(-/-) RBCs relative to control RBCs, indicating an appreciable loss of alpha2-3-linked sialic acids on the RBC surface of GPA(-/-) mice.	Sialic Acids	202-214	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	186-194
18339327-8	2008	The molecular mechanisms involved in Neu3-involved inhibition of CD41b surface antigen expression in K562 cells have been suggested: the Neu3 degrades membrane sialic acids and the resulting signaling pathway of the PKC/ERKs/p38 MAPK is down-regulated, causing a decrease in CD41b surface antigen expression and inhibition of megakaryocytic differentiation of K562 cells.	Sialic Acids	160-172	neuraminidase 3	Homo sapiens	37-41
18339327-8	2008	The molecular mechanisms involved in Neu3-involved inhibition of CD41b surface antigen expression in K562 cells have been suggested: the Neu3 degrades membrane sialic acids and the resulting signaling pathway of the PKC/ERKs/p38 MAPK is down-regulated, causing a decrease in CD41b surface antigen expression and inhibition of megakaryocytic differentiation of K562 cells.	Sialic Acids	160-172	integrin subunit alpha 2b	Homo sapiens	65-70
18339327-8	2008	The molecular mechanisms involved in Neu3-involved inhibition of CD41b surface antigen expression in K562 cells have been suggested: the Neu3 degrades membrane sialic acids and the resulting signaling pathway of the PKC/ERKs/p38 MAPK is down-regulated, causing a decrease in CD41b surface antigen expression and inhibition of megakaryocytic differentiation of K562 cells.	Sialic Acids	160-172	neuraminidase 3	Homo sapiens	137-141
18339327-8	2008	The molecular mechanisms involved in Neu3-involved inhibition of CD41b surface antigen expression in K562 cells have been suggested: the Neu3 degrades membrane sialic acids and the resulting signaling pathway of the PKC/ERKs/p38 MAPK is down-regulated, causing a decrease in CD41b surface antigen expression and inhibition of megakaryocytic differentiation of K562 cells.	Sialic Acids	160-172	mitogen-activated protein kinase 3	Homo sapiens	220-224
18339327-8	2008	The molecular mechanisms involved in Neu3-involved inhibition of CD41b surface antigen expression in K562 cells have been suggested: the Neu3 degrades membrane sialic acids and the resulting signaling pathway of the PKC/ERKs/p38 MAPK is down-regulated, causing a decrease in CD41b surface antigen expression and inhibition of megakaryocytic differentiation of K562 cells.	Sialic Acids	160-172	mitogen-activated protein kinase 1	Homo sapiens	225-228
18339327-8	2008	The molecular mechanisms involved in Neu3-involved inhibition of CD41b surface antigen expression in K562 cells have been suggested: the Neu3 degrades membrane sialic acids and the resulting signaling pathway of the PKC/ERKs/p38 MAPK is down-regulated, causing a decrease in CD41b surface antigen expression and inhibition of megakaryocytic differentiation of K562 cells.	Sialic Acids	160-172	integrin subunit alpha 2b	Homo sapiens	275-280
18275518-10	2008	The receptor-binding domain of PSG17 and PSG19 is post-translationally modified by the addition of N-linked carbohydrates and, when expressed in CHO cells, terminal sialic acids are detected.	Sialic Acids	165-177	pregnancy specific glycoprotein 17	Mus musculus	31-36
18275518-10	2008	The receptor-binding domain of PSG17 and PSG19 is post-translationally modified by the addition of N-linked carbohydrates and, when expressed in CHO cells, terminal sialic acids are detected.	Sialic Acids	165-177	pregnancy specific glycoprotein 19	Mus musculus	41-46
17520282-4	2008	We found that both SP-A1 and SP-A2 equally displayed alpha(2,3)-linked sialic acids, and had similar activity against a strain (PR-8) that preferentially binds to alpha(2,3)-linked sialic acids.	Sialic Acids	71-83	surfactant protein A1	Homo sapiens	19-24
17520282-4	2008	We found that both SP-A1 and SP-A2 equally displayed alpha(2,3)-linked sialic acids, and had similar activity against a strain (PR-8) that preferentially binds to alpha(2,3)-linked sialic acids.	Sialic Acids	71-83	surfactant protein A2	Homo sapiens	29-34
17520282-4	2008	We found that both SP-A1 and SP-A2 equally displayed alpha(2,3)-linked sialic acids, and had similar activity against a strain (PR-8) that preferentially binds to alpha(2,3)-linked sialic acids.	Sialic Acids	181-193	surfactant protein A1	Homo sapiens	19-24
17520282-4	2008	We found that both SP-A1 and SP-A2 equally displayed alpha(2,3)-linked sialic acids, and had similar activity against a strain (PR-8) that preferentially binds to alpha(2,3)-linked sialic acids.	Sialic Acids	181-193	surfactant protein A2	Homo sapiens	29-34
17580316-1	2007	CD33-related-Siglecs are lectins on immune cells that recognize sialic acids via extracellular domains, and deliver negative signals via cytosolic tyrosine-based regulatory motifs.	Sialic Acids	64-76	CD33 molecule	Homo sapiens	0-4
18043943-7	2008	The effect of sialic acids on channel gating, particularly inactivation gating, and the impact of other N-linked sugars on channel gating kinetics are unique to the ShB isoform.	Sialic Acids	14-26	shb	Drosophila melanogaster	165-168
17685443-4	2007	We treated cells with neuraminidase to remove sialic acids; as expected, this decreased total cell surface charge.	Sialic Acids	46-58	neuraminidase 1	Homo sapiens	22-35
17685443-11	2007	Because neuraminidase inhibited directional motility, we also conclude that sialic acids are required constituents of some cell surface molecule(s) through which electric fields mount a polarized transmembrane response.	Sialic Acids	76-88	neuraminidase 1	Homo sapiens	8-21
18341211-4	2007	CD34+CD38+ cells present either in diagnostic PB or BM always showed enhanced expression of both alpha2-3 and alpha2-6 linked sialic acids, Neu5,9Ac2-GPs, L- and P-selectins and VCAM-1, compared to CD34+CD38- population, as confirmed by higher mean fluorescence intensity (MFI).	Sialic Acids	126-138	CD34 molecule	Homo sapiens	0-4
18341211-4	2007	CD34+CD38+ cells present either in diagnostic PB or BM always showed enhanced expression of both alpha2-3 and alpha2-6 linked sialic acids, Neu5,9Ac2-GPs, L- and P-selectins and VCAM-1, compared to CD34+CD38- population, as confirmed by higher mean fluorescence intensity (MFI).	Sialic Acids	126-138	immunoglobulin binding protein 1	Homo sapiens	110-118
17692467-8	2007	Pgp isolated from MES-SA/Dx5 cells contains at least two different complex N-glycans--one high mannose tree, detected by GNA, and one branched hybrid oligosaccharide-capped with terminal sialic acids, detected by SNA and MAA.	Sialic Acids	187-199	ATP binding cassette subfamily B member 1	Homo sapiens	0-3
17637967-0	2007	Efficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids.	Sialic Acids	121-133	albumin	Homo sapiens	57-70
17448495-1	2007	The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is a key enzyme for the biosynthesis of sialic acids, the terminal sugars of glycoconjugates associated with a variety of physiological and pathological processes such as cell adhesion, development, inflammation and cancer.	Sialic Acids	133-145	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	24-86
17604005-2	2007	We and others have shown that Abeta binds with relatively high affinity to clustered sialic acid residues on cell surfaces and that removal of cell surface sialic acids attenuates Abeta toxicity.	Sialic Acids	156-168	amyloid beta precursor protein	Homo sapiens	30-35
17597614-1	2007	The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme of the biosynthesis of sialic acids, terminal components of glycoconjugates associated with a variety of cellular processes.	Sialic Acids	134-146	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	24-86
17597614-1	2007	The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme of the biosynthesis of sialic acids, terminal components of glycoconjugates associated with a variety of cellular processes.	Sialic Acids	134-146	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	88-91
17448495-1	2007	The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is a key enzyme for the biosynthesis of sialic acids, the terminal sugars of glycoconjugates associated with a variety of physiological and pathological processes such as cell adhesion, development, inflammation and cancer.	Sialic Acids	133-145	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	88-91
17490484-9	2007	We investigated whether a virus specific for alpha2-6 sialyloligosaccharides shows differential entry into cells that have varying proportions of alpha2-6 and alpha2-3 sialic acids, including human A549 and HeLa cells with high levels of alpha2-6 sialic acid, and CHO cells that have only alpha2-3 sialic acid.	Sialic Acids	168-180	immunoglobulin binding protein 1	Homo sapiens	45-53
16982154-2	2006	We and others have shown that Abeta binds with relatively high affinity to clustered sialic acid residues on cell surfaces and that removal of cell surface sialic acids attenuate Abeta toxicity.	Sialic Acids	156-168	amyloid beta precursor protein	Homo sapiens	30-35
17118363-6	2006	In this study, we searched for novel function of the GNE protein beside its enzymatic function in the Sia biosynthesis.	Sialic Acids	102-105	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	53-56
16923886-6	2006	A homologue of the NeuA C-terminal domain (Pm1710) in Pasteurella multocida was also shown to be an esterase, suggesting that it functions in the catabolism of acetylated environmental sialic acids.	Sialic Acids	185-197	alpha/beta fold hydrolase	Pasteurella multocida	100-108
16490286-5	2006	Using enzymatic deglycosylation of clusterin isolated from cerebrospinal fluid, we found that the carbohydrates attached to clusterin were of the N-linked type and sialic acids.	Sialic Acids	164-176	clusterin	Homo sapiens	35-44
16569393-1	2006	Sialic acids and proteins bound to mucins are known to form complexes with calcium, and this mechanism may hamper the remineralization of calcium-containing mucin-based saliva substitutes.	Sialic Acids	0-12	mucin 1, cell surface associated	Bos taurus	35-40
16841601-1	2006	OBJECTIVES: Remineralization of dentin by mucin-containing saliva substitutes might be inhibited by sialic acids bound to mucin, which are known to complex calcium.	Sialic Acids	100-112	mucin 1, cell surface associated	Bos taurus	42-47
16841601-1	2006	OBJECTIVES: Remineralization of dentin by mucin-containing saliva substitutes might be inhibited by sialic acids bound to mucin, which are known to complex calcium.	Sialic Acids	100-112	mucin 1, cell surface associated	Bos taurus	122-127
16490286-5	2006	Using enzymatic deglycosylation of clusterin isolated from cerebrospinal fluid, we found that the carbohydrates attached to clusterin were of the N-linked type and sialic acids.	Sialic Acids	164-176	clusterin	Homo sapiens	124-133
16469746-11	2006	The decreased hyaluronan binding of SPACR was induced by an inhibitory effect of the excess of sialic acids in the adult stage.	Sialic Acids	95-107	interphotoreceptor matrix proteoglycan 1	Gallus gallus	36-41
16622833-5	2006	The variability of the number of antennae and hence sialic acids on glycosylation site N107, which even contained minute amounts of tetraantennary structures, emerged as a major cause for the IEF pattern of A1PI.	Sialic Acids	52-64	serpin family A member 1	Homo sapiens	207-211
16497558-1	2006	Erythrocyte-binding antigen 175 (EBA175) is one of the best-characterized Plasmodium falciparum merozoite ligands; the recently solved crystal structure of EBA175 reveals that terminal sialic acids on the erythrocyte glycoprotein glycophorin A are a crucial factor for erythrocyte recognition by EBA175 because they lock into pockets on its surface.	Sialic Acids	185-197	PRSY57_0010500D	Plasmodium reichenowi	33-39
16497558-1	2006	Erythrocyte-binding antigen 175 (EBA175) is one of the best-characterized Plasmodium falciparum merozoite ligands; the recently solved crystal structure of EBA175 reveals that terminal sialic acids on the erythrocyte glycoprotein glycophorin A are a crucial factor for erythrocyte recognition by EBA175 because they lock into pockets on its surface.	Sialic Acids	185-197	PRSY57_0010500D	Plasmodium reichenowi	156-162
16497558-1	2006	Erythrocyte-binding antigen 175 (EBA175) is one of the best-characterized Plasmodium falciparum merozoite ligands; the recently solved crystal structure of EBA175 reveals that terminal sialic acids on the erythrocyte glycoprotein glycophorin A are a crucial factor for erythrocyte recognition by EBA175 because they lock into pockets on its surface.	Sialic Acids	185-197	PRSY57_0010500D	Plasmodium reichenowi	156-162
16575520-5	2006	However, the current evidence suggests that even these neuraminidase-resistant strains might interact with sialic acids located in context different from that of the sialic acids used by the neuraminidase-sensitive strains.	Sialic Acids	107-119	neuraminidase 1	Homo sapiens	55-68
16314420-8	2006	We postulate that neuraminidase-1 catalyzes removal of the terminal sialic acids from carbohydrate chains of microfibrillar glycoproteins and other adjacent matrix glycoconjugates, unmasking their penultimate galactosugars.	Sialic Acids	68-80	neuraminidase 1	Homo sapiens	18-33
16575520-5	2006	However, the current evidence suggests that even these neuraminidase-resistant strains might interact with sialic acids located in context different from that of the sialic acids used by the neuraminidase-sensitive strains.	Sialic Acids	166-178	neuraminidase 1	Homo sapiens	55-68
16014806-6	2005	Moreover, Western blot analysis with lectins specific for alpha(2,3) and alpha(2,6)-linked sialic acids and lectin-binding enzyme-linked immunosorbent assay support a direct effect on TSHR cell-surface expression mediated by sialic acid transfer to the TSHR.	Sialic Acids	91-103	thyroid stimulating hormone receptor	Homo sapiens	184-188
16575520-5	2006	However, the current evidence suggests that even these neuraminidase-resistant strains might interact with sialic acids located in context different from that of the sialic acids used by the neuraminidase-sensitive strains.	Sialic Acids	166-178	neuraminidase 1	Homo sapiens	191-204
16190864-3	2006	Although lung and salivary gp-340 are identical in protein sequence, salivary gp-340 from one donor had significantly greater antiviral activity against avian-like IAV strains which preferentially bind sialic acids in alpha(2,3) linkage.	Sialic Acids	202-214	deleted in malignant brain tumors 1	Homo sapiens	78-84
16190864-4	2006	A greater density of alpha(2,3)-linked sialic acids was present on the salivary gp-340 from this donor as compared with salivary gp-340 from another donor or several preparations of lung gp-340.	Sialic Acids	39-51	deleted in malignant brain tumors 1	Homo sapiens	80-86
16489296-1	2006	The new biochemical marker of chronic alcohol abuse are transferrin isoforms with a reduced number of sialic acids (asialo-, monosialo-, and disialotransferrin) called carbohydrate-deficient transferrins (CDTs).	Sialic Acids	102-114	transferrin	Homo sapiens	56-67
16439595-4	2006	More detailed analysis of Tf by electrospray ionization mass spectrometry (ESI-MS) showed a plethora of abnormal glycosylations that included loss of 1-2 sialic acids and 1-2 galactose units, typical of Group II defects.	Sialic Acids	154-166	transferrin	Homo sapiens	26-28
16373174-7	2006	In a direct ligand binding assay, desialylated alpha3beta1 integrin exhibited significantly higher fibronectin-binding capability than untreated integrin, providing evidence that sialic acids play a direct role in ligand-receptor interaction.	Sialic Acids	179-191	fibronectin 1	Homo sapiens	99-110
16137682-1	2005	Sialic acids are expressed as terminal sugars in many glycoconjugates and play an important role during development and regeneration, as they are involved as polysialic acid in a variety of cell-cell interactions mediated by the neural cell adhesion molecule NCAM.	Sialic Acids	0-12	neural cell adhesion molecule 1	Homo sapiens	259-263
15950996-2	2005	The influenza neuraminidase (NA) can cleave both alpha2,3- and alpha2,6-linked sialic acids, but all influenza NAs have a marked preference for the non-human alpha2,3 linkage.	Sialic Acids	79-91	neuraminidase 1	Homo sapiens	14-27
15515124-1	2005	Sialic acids occupy terminal positions on gastric mucus glycoprotein where they contribute to the high viscosity of mucin.	Sialic Acids	0-12	solute carrier family 13 member 2	Rattus norvegicus	116-121
15950996-2	2005	The influenza neuraminidase (NA) can cleave both alpha2,3- and alpha2,6-linked sialic acids, but all influenza NAs have a marked preference for the non-human alpha2,3 linkage.	Sialic Acids	79-91	neuraminidase 1	Homo sapiens	29-31
15510212-2	2004	Sialic acids cleaved off from degraded sialoglycoconjugates are exported from lysosomes by a membrane transporter, named sialin, which is defective in two allelic inherited diseases: infantile sialic acid storage disease (ISSD) and Salla disease.	Sialic Acids	0-12	solute carrier family 17 member 5	Homo sapiens	121-127
16002706-3	2005	In view of the implication of positively charged amino acid residues present in variable regions in IgG3 cryoglobulin activity, we explored the role of terminal sialic acids in oligosaccharide side chains for the cryogenic activity of IgG3 mAb.	Sialic Acids	161-173	Immunoglobulin heavy constant gamma 3	Mus musculus	235-239
16002706-8	2005	Our results thus suggest that the content of negatively charged sialic acids in oligosaccharide side chains is one of the critical factors to determine IgG3 cryoglobulin activity, along with amino acid sequences of the IgG3 variable regions.	Sialic Acids	64-76	Immunoglobulin heavy constant gamma 3	Mus musculus	152-156
15922967-4	2005	Removal of negatively charged sialic acids in ProDer p 1 or increasing the ionic strength reduced the binding of ProDer p 1 to the cationic liposomes and resulted in a decrease of the allergen immunogenicity, suggesting that complexation is required for triggering an optimal immune response.	Sialic Acids	30-42	zinc finger protein 185	Mus musculus	53-56
15922967-4	2005	Removal of negatively charged sialic acids in ProDer p 1 or increasing the ionic strength reduced the binding of ProDer p 1 to the cationic liposomes and resulted in a decrease of the allergen immunogenicity, suggesting that complexation is required for triggering an optimal immune response.	Sialic Acids	30-42	zinc finger protein 185	Mus musculus	120-123
15770663-9	2005	Taken together, it is reasonable to hypothesise that O-acetylation of sialic acids on PBMC(ALL) may be an additional mechanism that promotes the survival of lymphoblasts by avoiding apoptosis via IFN-gamma-induced NO production.	Sialic Acids	70-82	interferon gamma	Homo sapiens	196-205
15516336-1	2005	In Neisseria meningitidis and related bacterial pathogens, sialic acids play critical roles in mammalian cell immunity evasion and are synthesized by a conserved enzymatic pathway that includes sialic acid synthase (NeuB, SiaC, or SynC).	Sialic Acids	59-71	N-acetylneuraminate synthase	Homo sapiens	194-214
15498764-2	2004	The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase is the key enzyme for the biosynthesis of sialic acids.	Sialic Acids	129-141	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	24-86
15383529-8	2004	These data define the region in the RPTPbeta extracellular domain critical for VacA binding, in particular the sequence QTTQP at positions 747-751 with crucial threonines at positions 748 and 749 and are consistent with a role for terminal sialic acids possibly because of threonine glycosylation.	Sialic Acids	240-252	protein tyrosine phosphatase receptor type Z1	Homo sapiens	36-44
14672916-4	2004	Hemagglutination inhibition analysis shows that the distinct interactions of pSP-D with IAV mediated by the N-linked carbohydrate moiety in the carbohydrate recognition domain of pSP-D depend on the terminal sialic acids (SAs) present on this carbohydrate.	Sialic Acids	208-220	surfactant protein D	Homo sapiens	77-82
15240561-2	2004	CD22 recognizes alpha2-6-linked sialic acids (Sias) via an amino-terminal Ig-like domain.	Sialic Acids	32-44	CD22 molecule	Homo sapiens	0-4
15316006-7	2004	Data also suggest an interaction between the cis effect of alpha sialic acids and the trans effect of beta1 sialic acids on channel gating.	Sialic Acids	108-120	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	102-107
15316006-10	2004	Together, the data indicate that beta1 N-linked sialic acids can modulate Nav gating through an apparent saturating electrostatic mechanism.	Sialic Acids	48-60	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	33-38
15242781-0	2004	Selective inhibition of polysialyltransferase ST8SiaII by unnatural sialic acids.	Sialic Acids	68-80	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	46-54
14672916-4	2004	Hemagglutination inhibition analysis shows that the distinct interactions of pSP-D with IAV mediated by the N-linked carbohydrate moiety in the carbohydrate recognition domain of pSP-D depend on the terminal sialic acids (SAs) present on this carbohydrate.	Sialic Acids	208-220	surfactant protein D	Homo sapiens	179-184
14672916-4	2004	Hemagglutination inhibition analysis shows that the distinct interactions of pSP-D with IAV mediated by the N-linked carbohydrate moiety in the carbohydrate recognition domain of pSP-D depend on the terminal sialic acids (SAs) present on this carbohydrate.	Sialic Acids	222-225	surfactant protein D	Homo sapiens	77-82
14672916-4	2004	Hemagglutination inhibition analysis shows that the distinct interactions of pSP-D with IAV mediated by the N-linked carbohydrate moiety in the carbohydrate recognition domain of pSP-D depend on the terminal sialic acids (SAs) present on this carbohydrate.	Sialic Acids	222-225	surfactant protein D	Homo sapiens	179-184
15099204-6	2004	Cells were treated with (i) alpha-galactosidase, and then (ii) neuraminidase, which digests sialic acids, including NeuGc epitopes.	Sialic Acids	92-104	neuraminidase 1	Homo sapiens	63-76
12888916-0	2003	Sialic acids linked to glycoconjugates of Fas regulate the caspase-9-dependent and mitochondria-mediated pathway of Fas-induced apoptosis in Jurkat T cell lymphoma.	Sialic Acids	0-12	caspase 9	Homo sapiens	59-68
14750790-1	2004	The "epimerisation" of UDP-GlcNAc to ManNAc, the first step in the biosynthesis of sialic acids, is catalyzed by UDP-GlcNAc 2-epimerase.	Sialic Acids	83-95	renin binding protein	Homo sapiens	117-135
15133980-4	2004	This study investigated the effects of exposure to transforming growth factor-beta 1 (TGF-beta 1) and tumor necrosis factor-a (TNF-a) on the expression of cell surface GAGs and sialic acids on human umbilical vein endothelial cells (HUVECs).	Sialic Acids	177-189	transforming growth factor beta 1	Homo sapiens	86-94
15133980-4	2004	This study investigated the effects of exposure to transforming growth factor-beta 1 (TGF-beta 1) and tumor necrosis factor-a (TNF-a) on the expression of cell surface GAGs and sialic acids on human umbilical vein endothelial cells (HUVECs).	Sialic Acids	177-189	tumor necrosis factor	Homo sapiens	127-132
15133980-9	2004	These data indicate that TNF-a and TGF-beta 1 play a role in the expression of GAG chains and sialic acids on the cell surface.	Sialic Acids	94-106	tumor necrosis factor	Homo sapiens	25-30
15133980-9	2004	These data indicate that TNF-a and TGF-beta 1 play a role in the expression of GAG chains and sialic acids on the cell surface.	Sialic Acids	94-106	transforming growth factor beta 1	Homo sapiens	35-45
14717696-3	2004	Two enzymes are thought to be primarily responsible for the turnover of O-acetyl ester groups on sialic acids; sialate-O-acetyltransferase (OAT) and sialate-O-acetylesterase (OAE).	Sialic Acids	97-109	sialic acid acetylesterase	Homo sapiens	149-173
14717696-3	2004	Two enzymes are thought to be primarily responsible for the turnover of O-acetyl ester groups on sialic acids; sialate-O-acetyltransferase (OAT) and sialate-O-acetylesterase (OAE).	Sialic Acids	97-109	sialic acid acetylesterase	Homo sapiens	175-178
14717696-6	2004	Utilizing matched resection margin and cancer tissue from colorectal carcinoma patients we provide strong evidence suggesting that the level of O-acetylated sialic acids present in normal and diseased human colon may be dependent on the relative activities of OAT to lysosomal OAE.	Sialic Acids	157-169	sialic acid acetylesterase	Homo sapiens	277-280
14730275-7	2004	Experimental studies demonstrate that viral NA exposes pneumococcal receptors on host cells by removing terminal sialic acids.	Sialic Acids	113-125	neuraminidase 1	Homo sapiens	44-46
14522992-6	2003	Incomplete processing of the protein and enzymatic removal of the oligosaccharides chain or the terminal sialic acids from neuroligin-1 enhance its activity, whereas deglycosylation of neurexin-1beta did not alter its association capacity.	Sialic Acids	105-117	neuroligin 1	Homo sapiens	123-135
14562042-5	2003	Results from RT-PCR analyses suggest that differential integrin sialylation is due to a ras-dependent alteration in the expression of ST6Gal I, the enzyme that adds alpha2-6-linked sialic acids.	Sialic Acids	181-193	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	134-142
14562042-5	2003	Results from RT-PCR analyses suggest that differential integrin sialylation is due to a ras-dependent alteration in the expression of ST6Gal I, the enzyme that adds alpha2-6-linked sialic acids.	Sialic Acids	181-193	immunoglobulin binding protein 1	Homo sapiens	165-173
14562042-8	2003	Finally, using a cell-free receptor/ligand-binding assay, we show that purified, desialylated alpha1beta1 integrins have diminished collagen-binding capability, providing strong evidence that sialic acids play a causal role in regulating beta1 integrin function.	Sialic Acids	192-204	integrin subunit beta 1	Homo sapiens	100-114
12783618-3	2003	Darbepoetin alfa (Aranesp), Amgen Inc, Thousand Oaks, California), a new erythropoietic growth factor, has eight more sialic acids than epoetin alfa.	Sialic Acids	118-130	erythropoietin	Homo sapiens	4-11
22900313-5	2003	The importance of sialic acids in biochemical phenomena and the distinct roles played by specific forms of these amino sugars is adequately reflected in functional studies of selectin and sialoadhesin families of adhesion molecules.	Sialic Acids	18-30	sialic acid binding Ig like lectin 1	Homo sapiens	188-200
12395152-0	2002	Biochemical engineering of the acyl side chain of sialic acids stimulates integrin-dependent adhesion of HL60 cells to fibronectin.	Sialic Acids	50-62	fibronectin 1	Homo sapiens	119-130
12637583-4	2003	The O-glycan regions on the heavy (H) chains and the SC N-glycans have adhesin-binding glycan epitopes including galactose-linked beta1-4 and beta1-3 to GlcNAc, fucose-linked alpha1-3 and alpha1-4 to GlcNAc and alpha1-2 to galactose, and alpha2-3 and alpha2-6-linked sialic acids.	Sialic Acids	267-279	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	142-149
12637583-4	2003	The O-glycan regions on the heavy (H) chains and the SC N-glycans have adhesin-binding glycan epitopes including galactose-linked beta1-4 and beta1-3 to GlcNAc, fucose-linked alpha1-3 and alpha1-4 to GlcNAc and alpha1-2 to galactose, and alpha2-3 and alpha2-6-linked sialic acids.	Sialic Acids	267-279	adrenoceptor alpha 1D	Homo sapiens	161-196
12438625-5	2002	We found that VLP bound to sialoglycoproteins, including alpha1-acid glycoprotein, fetuin, and transferrin receptor, and that this binding depended on alpha2-3-linked sialic acids and N-linked sugar chains.	Sialic Acids	167-179	VHL like	Homo sapiens	14-17
12487819-7	2002	Removal of sialic acids from rgp120 with NA enhanced MBL binding.	Sialic Acids	11-23	neuraminidase 1	Homo sapiens	41-43
12487819-7	2002	Removal of sialic acids from rgp120 with NA enhanced MBL binding.	Sialic Acids	11-23	mannose binding lectin 2	Homo sapiens	53-56
12530538-3	2002	The sialidase removed terminal sialic acids from gangliosides GM3, GM4, GD3, GD2, GD1 a, GD1 b, GT1 b and GQ1 b, but was inactive toward gangliosides with sialic acid in a branching position (as in GM1 and GM2).	Sialic Acids	31-43	GRDX	Homo sapiens	72-75
12530538-3	2002	The sialidase removed terminal sialic acids from gangliosides GM3, GM4, GD3, GD2, GD1 a, GD1 b, GT1 b and GQ1 b, but was inactive toward gangliosides with sialic acid in a branching position (as in GM1 and GM2).	Sialic Acids	31-43	beta-1,4-galactosyltransferase 1	Homo sapiens	96-99
11986327-6	2002	First, it binds specifically to alpha2-8-linked sialic acids.	Sialic Acids	48-60	immunoglobulin binding protein 1	Homo sapiens	32-40
12223090-4	2002	Isolated enzyme in the presence of saccharide-acceptor can remove sialic acids from different lipoproteins, glycoproteins (fetuin, transferrin), and gangliosides (GM3, GD3, GM1, GD1a, GD1b).	Sialic Acids	66-78	transferrin	Homo sapiens	131-142
12223090-5	2002	Plasma enzyme translocates alpha2-6, alpha2-3 and to a lower extent alpha2-8 bonded sialic acids.	Sialic Acids	84-96	immunoglobulin binding protein 1	Homo sapiens	68-76
12048209-3	2002	In the present study, I discovered that dithreonine residues (Thr-15 and Thr-16) at the intravesicular domain of mouse Syt I are post-translationally modified by a complex form of O-linked sugar (i.e. the addition of sialic acids) in PC12 cells and that the O-glycosylation of Syt I in COS-7 cells depends on the coexpression of vesicle-associated membrane protein-2 (VAMP-2)/synaptobrevin.	Sialic Acids	217-229	synaptotagmin I	Mus musculus	119-124
12048209-3	2002	In the present study, I discovered that dithreonine residues (Thr-15 and Thr-16) at the intravesicular domain of mouse Syt I are post-translationally modified by a complex form of O-linked sugar (i.e. the addition of sialic acids) in PC12 cells and that the O-glycosylation of Syt I in COS-7 cells depends on the coexpression of vesicle-associated membrane protein-2 (VAMP-2)/synaptobrevin.	Sialic Acids	217-229	synaptotagmin 1	Rattus norvegicus	277-282
11322763-0	2001	Biochemical engineering of the side chain of sialic acids increases the biological stability of the highly sialylated cell adhesion molecule CEACAM1.	Sialic Acids	45-57	CEA cell adhesion molecule 1	Homo sapiens	141-148
11751912-5	2002	Uptake of C-5- and C-9-substituted sialic acids resulted in the structural modification of up to 95% of sialic acids on the cell surface.	Sialic Acids	35-47	complement C5	Homo sapiens	10-13
11751912-5	2002	Uptake of C-5- and C-9-substituted sialic acids resulted in the structural modification of up to 95% of sialic acids on the cell surface.	Sialic Acids	35-47	complement C9	Homo sapiens	19-22
11751912-5	2002	Uptake of C-5- and C-9-substituted sialic acids resulted in the structural modification of up to 95% of sialic acids on the cell surface.	Sialic Acids	104-116	complement C5	Homo sapiens	10-13
11751912-5	2002	Uptake of C-5- and C-9-substituted sialic acids resulted in the structural modification of up to 95% of sialic acids on the cell surface.	Sialic Acids	104-116	complement C9	Homo sapiens	19-22
11886840-4	2002	The identification of a functional sialic acid synthase in Drosophila indicates that insects have the biosynthetic capability to produce sialic acids endogenously.	Sialic Acids	137-149	N-acetylneuraminic acid synthase	Drosophila melanogaster	35-55
11814568-5	2002	Similar to EBA-175, the binding of EBP2/BAEBL to human erythrocytes was dependent on sialic acids because neuraminidase treatment of those erythrocytes rendered them incapable of binding, but differed from EBA-175 in that trypsin treatment decreased EBP2/BAEBL binding by only twofold compared to a 10-fold reduction in EBA-175 binding.	Sialic Acids	85-97	EBNA1 binding protein 2	Homo sapiens	35-39
11814568-5	2002	Similar to EBA-175, the binding of EBP2/BAEBL to human erythrocytes was dependent on sialic acids because neuraminidase treatment of those erythrocytes rendered them incapable of binding, but differed from EBA-175 in that trypsin treatment decreased EBP2/BAEBL binding by only twofold compared to a 10-fold reduction in EBA-175 binding.	Sialic Acids	85-97	neuraminidase 1	Homo sapiens	106-119
11989668-5	2001	Buffalo plasma FN contained 2.23% neutral hexoses and 1.18% sialic acids.	Sialic Acids	60-72	fibronectin 1	Homo sapiens	15-17
11687291-4	2001	For example, the sialic acids of gelatinase B influence the catalytic activity of this enzyme in a complex with the tissue inhibitor of metalloproteinases-1 (TIMP-1).	Sialic Acids	17-29	TIMP metallopeptidase inhibitor 1	Homo sapiens	116-156
11687291-4	2001	For example, the sialic acids of gelatinase B influence the catalytic activity of this enzyme in a complex with the tissue inhibitor of metalloproteinases-1 (TIMP-1).	Sialic Acids	17-29	TIMP metallopeptidase inhibitor 1	Homo sapiens	158-164
11418585-8	2001	Treatment of cells with sialidase from Arthrobacter ureafaciens cleaving alpha 2-3-, alpha 2-6-, and alpha 2-8-linked sialic acids inhibited adhesion to fibronectin.	Sialic Acids	118-130	fibronectin 1	Homo sapiens	153-164
11786551-0	2002	Differential effects of unnatural sialic acids on the polysialylation of the neural cell adhesion molecule and neuronal behavior.	Sialic Acids	34-46	neural cell adhesion molecule 1	Homo sapiens	77-106
11786551-1	2002	In this study we have examined how unnatural sialic acids can alter polysialic acid expression and influence the adhesive properties of the neural cell adhesion molecule (NCAM).	Sialic Acids	45-57	neural cell adhesion molecule 1	Homo sapiens	140-169
11786551-1	2002	In this study we have examined how unnatural sialic acids can alter polysialic acid expression and influence the adhesive properties of the neural cell adhesion molecule (NCAM).	Sialic Acids	45-57	neural cell adhesion molecule 1	Homo sapiens	171-175
11826157-6	2002	Functional analysis of two chimeras, hSkM1P1 and hH1P1, indicated that the responsible sialic acids are localized to the hSkM1 S5-S6 loop of domain I.	Sialic Acids	87-99	sodium voltage-gated channel alpha subunit 4	Homo sapiens	37-42
11739166-8	2001	Determination of charge state after treatment of human serum EPO with Arthrobacter ureafaciens sialidase showed that the acidity of the oligosaccharide structures was caused by sialic acids.	Sialic Acids	177-189	erythropoietin	Homo sapiens	61-64
11579105-2	2001	Unlike most human Siglec-3 (hSiglec-3)-related Siglecs with promiscuous linkage specificity, mSiglec-F shows a strong preference for alpha2-3-linked sialic acids.	Sialic Acids	149-161	sialic acid binding Ig-like lectin F	Mus musculus	93-102
10978165-7	2000	Glycosylated HCC-1 exhibits a molecular mass of 9621 Da due to O-glycosylation at position 7 (Ser-7) with two N-acetylneuraminic acids and the disaccharide N-acetylgalactosamine galactose.	Sialic Acids	110-134	C-C motif chemokine ligand 14	Homo sapiens	13-18
11264365-2	2001	The HA binds to sialyloligosaccharide viral receptors, while the NA removes sialic acids from the host cell and viral sialyloligosaccarides.	Sialic Acids	76-88	neuraminidase 1	Homo sapiens	65-67
11300878-1	2001	Neuraminidase is a surface glycoprotein of influenza viruses that cleaves terminal sialic acids from carbohydrates.	Sialic Acids	83-95	neuraminidase 1	Homo sapiens	0-13
11160731-8	2001	Thus, neuraminidase-sensitive strains bind to external sialic acid residues in gangliosides, while neuraminidase-insensitive strains recognize gangliosides with internal sialic acids, which are resistant to neuraminidase treatment.	Sialic Acids	170-182	neuraminidase 1	Bos taurus	99-112
11160731-8	2001	Thus, neuraminidase-sensitive strains bind to external sialic acid residues in gangliosides, while neuraminidase-insensitive strains recognize gangliosides with internal sialic acids, which are resistant to neuraminidase treatment.	Sialic Acids	170-182	neuraminidase 1	Bos taurus	99-112
11511809-5	2000	Radio thin-layer chromatography analyses of propionic acid-released sialic acids showed that the incorporation of radioactivity correlated with the formation of a radiolabelled species that co-migrated with authentic Neu4,5Ac2.	Sialic Acids	68-80	neuraminidase 4	Equus caballus	217-226
11238305-7	2001	RESULTS: The LC-MS method demonstrated that the major abnormal Trf isoforms in CDG lack one complete oligosaccharide structure (mono-oligosaccharide) or both oligosaccharide structures (a-oligosaccharide), but not the sialic acids, as presumed on the basis of IEF methods.	Sialic Acids	218-230	transferrin	Homo sapiens	63-66
10460833-9	1999	Hence, cell surface sialic acids might play a role in VE-cadherin organization.	Sialic Acids	20-32	cadherin 5	Homo sapiens	54-65
10569415-5	1999	RESULTS: The cholesteatomas that exhibited the highest proportion of apoptotic cells were those which exhibited the highest level of sarcolectin-binding sites (i.e., sialic acids).	Sialic Acids	166-178	keratin 7	Homo sapiens	133-144
10486256-2	1999	In the present study we show the in vivo modulation of sialic acids in membrane-bound dipeptidyl peptidase IV (CD 26) from rat liver after administration of N-propanoyl-D-mannosamine.	Sialic Acids	55-67	dipeptidylpeptidase 4	Rattus norvegicus	86-109
10486256-2	1999	In the present study we show the in vivo modulation of sialic acids in membrane-bound dipeptidyl peptidase IV (CD 26) from rat liver after administration of N-propanoyl-D-mannosamine.	Sialic Acids	55-67	dipeptidylpeptidase 4	Rattus norvegicus	111-116
10801860-8	2000	A recombinant soluble form of the extracellular domain binds to alpha2-3 and alpha2-6-linked sialic acids.	Sialic Acids	93-105	immunoglobulin binding protein 1	Homo sapiens	77-85
10929819-0	2000	Determination of mucin in salivary glands using sialic acids as the marker by high-performance liquid chromatography with fluorometric detection.	Sialic Acids	48-60	LOC100508689	Homo sapiens	17-22
10814695-2	2000	We now report high titers of IgG antibodies directed against O-acetylated derivatives of sialic acids (O-AcSA) in serum of ALL patients.	Sialic Acids	89-101	acyl-CoA synthetase short chain family member 2	Homo sapiens	105-109
10215318-10	1999	Both poly alpha2,8 KDN and sialic acids on megalin may contribute to the binding of Ca2+ and cationic ligands.	Sialic Acids	27-39	LDL receptor related protein 2	Rattus norvegicus	43-50
10453033-4	1999	Removing both alpha 2,6- and alpha 2,3-linked sialic acids from IL-1 + IL-4-costimulated HUVEC by sialidase significantly increased VCAM-1-dependent adhesion, whereas removing alpha 2,3-linked sialic acid alone had no effect; adenovirus-mediated overexpression of ST6N with costimulation almost abolished the adhesion, which was reversible by sialidase.	Sialic Acids	46-58	interleukin 1 alpha	Homo sapiens	64-68
10453033-4	1999	Removing both alpha 2,6- and alpha 2,3-linked sialic acids from IL-1 + IL-4-costimulated HUVEC by sialidase significantly increased VCAM-1-dependent adhesion, whereas removing alpha 2,3-linked sialic acid alone had no effect; adenovirus-mediated overexpression of ST6N with costimulation almost abolished the adhesion, which was reversible by sialidase.	Sialic Acids	46-58	interleukin 4	Homo sapiens	71-75
10453033-4	1999	Removing both alpha 2,6- and alpha 2,3-linked sialic acids from IL-1 + IL-4-costimulated HUVEC by sialidase significantly increased VCAM-1-dependent adhesion, whereas removing alpha 2,3-linked sialic acid alone had no effect; adenovirus-mediated overexpression of ST6N with costimulation almost abolished the adhesion, which was reversible by sialidase.	Sialic Acids	46-58	vascular cell adhesion molecule 1	Homo sapiens	132-138
10453033-4	1999	Removing both alpha 2,6- and alpha 2,3-linked sialic acids from IL-1 + IL-4-costimulated HUVEC by sialidase significantly increased VCAM-1-dependent adhesion, whereas removing alpha 2,3-linked sialic acid alone had no effect; adenovirus-mediated overexpression of ST6N with costimulation almost abolished the adhesion, which was reversible by sialidase.	Sialic Acids	46-58	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	264-268
10353318-0	1999	Modification of lipoprotein lipase catalytic activity by sialic acids.	Sialic Acids	57-69	lipoprotein lipase	Homo sapiens	16-34
29711309-0	1998	Synthesis of Immobilized CMP-Sialic Acids and Their Enzymatic Transfer with Sialyltransferase.	Sialic Acids	29-41	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	76-93
19003337-6	1999	Under non- induced conditions, IFN expressed by alpha2,6-engineered cells contained 68% of the total sialic acids in the alpha2,6- conformation and the overall molar ratio of sialic acids to IFN was 2.3.	Sialic Acids	101-113	interferon alpha 1	Homo sapiens	31-34
19003337-6	1999	Under non- induced conditions, IFN expressed by alpha2,6-engineered cells contained 68% of the total sialic acids in the alpha2,6- conformation and the overall molar ratio of sialic acids to IFN was 2.3.	Sialic Acids	175-187	interferon alpha 1	Homo sapiens	31-34
19003337-7	1999	Sodium butyrate addition increased twofold the molar ratio of total sialic acids to IFN and 82% of total sialic acids on IFN were in the alpha2,6-conformation.	Sialic Acids	105-117	interferon alpha 1	Homo sapiens	121-124
9406434-8	1997	Sialic acid-induced heterogeneity has been documented for many enzymes, but neuraminidase treatment can often remove sialic acids and produce gel patterns that are easier to interpret.	Sialic Acids	117-129	neuraminidase 1	Homo sapiens	76-89
9804253-8	1998	In all cases, HMFG-1 reactivity could be restored by predigestion with keratanase or neuraminidase which removes keratan sulphates and sialic acids, respectively.	Sialic Acids	135-147	neuraminidase 1	Homo sapiens	85-98
10097520-4	1998	It is well known that in vivo bioactivity and metabolic fate of EPO are dependent on the number of sialic acids and the degree of branching in the carbohydrate moieties.	Sialic Acids	99-111	erythropoietin	Homo sapiens	64-67
9466714-6	1997	Upon neuraminidase treatment, which cleaves sialic acids, these differences in molecular weight were abolished.	Sialic Acids	44-56	neuraminidase 1	Homo sapiens	5-18
9438535-2	1997	The least sialylated isoforms of Tf; with 0 (asialo Tf), 1 (monosialo Tf), and 2 (disialo Tf) sialic acids are referred to as carbohydrate-deficient transferrin (CDT).	Sialic Acids	94-106	transferrin	Homo sapiens	33-35
9438535-2	1997	The least sialylated isoforms of Tf; with 0 (asialo Tf), 1 (monosialo Tf), and 2 (disialo Tf) sialic acids are referred to as carbohydrate-deficient transferrin (CDT).	Sialic Acids	94-106	transferrin	Homo sapiens	149-160
9874196-1	1998	The neuraminidase of influenza virus is a surface glycoprotein that catalyzes the hydrolysis of glycosidic linkages between terminal sialic acids and adjacent sugar moieties.	Sialic Acids	133-145	neuraminidase 1	Homo sapiens	4-17
9474014-2	1998	The isoelectric points of the variant and normal CD13 were 3.3 and 4.1, respectively, and both points converged at 4.4 after treatment with neuraminidase, indicating that more sialic acids are bound to the variant CD13 than normal.	Sialic Acids	176-188	alanyl aminopeptidase, membrane	Homo sapiens	49-53
9474014-2	1998	The isoelectric points of the variant and normal CD13 were 3.3 and 4.1, respectively, and both points converged at 4.4 after treatment with neuraminidase, indicating that more sialic acids are bound to the variant CD13 than normal.	Sialic Acids	176-188	neuraminidase 1	Homo sapiens	140-153
9474014-2	1998	The isoelectric points of the variant and normal CD13 were 3.3 and 4.1, respectively, and both points converged at 4.4 after treatment with neuraminidase, indicating that more sialic acids are bound to the variant CD13 than normal.	Sialic Acids	176-188	alanyl aminopeptidase, membrane	Homo sapiens	214-218
9201997-5	1997	In contrast, sialoadhesin had less exacting specificity, binding to gangliosides that bear either terminal alpha2,3- or alpha2,8-linked sialic acids with the following rank-order potency of binding: GQ1balpha > GD1a = GD1b = GT1b = GM3 = GM4 > GD3 = GQ1b >> GM1 (nonbinder).	Sialic Acids	136-148	sialic acid binding Ig like lectin 1	Homo sapiens	13-25
9299469-3	1997	Plate inhibition assays with isolated, structurally defined N-glycans as inhibitors of binding of NKR-P1A to GlcNAc16-BSA revealed that the removal of both the external sialic acids and the penultimate galactose residues resulted in attaining of significant inhibitory activities.	Sialic Acids	169-181	killer cell lectin-like receptor subfamily B, member 1A	Rattus norvegicus	98-105
9201997-11	1997	These data are consistent with sialoadhesin binding to one face of the sialic acid moiety, whereas MAG (and SMP) may have more complex binding sites or may bind sialic acids only in the context of more restricted oligosaccharide conformations.	Sialic Acids	161-173	myelin associated glycoprotein	Homo sapiens	99-102
9253768-0	1997	Determination of viral neuraminidase specificity for membrane-bound sialic acids by cell electrophoresis.	Sialic Acids	68-80	neuraminidase 1	Homo sapiens	23-36
21432455-6	1997	Thus the change rate of sialic acids (SA) increased significantly in both the IL-6 unchanged and increased groups.	Sialic Acids	24-36	interleukin 6	Homo sapiens	78-82
9249154-2	1997	Neuraminidase enzymes recognize and cleave terminal sialic acids from cell surfaces.	Sialic Acids	52-64	neuraminidase 1	Homo sapiens	0-13
9219830-5	1997	The O-acetylation of mucin-bound sialyl-Le(x) gradually decreased from N to M. HPLC analysis showed that in N about 70%, in T 45% and in M only 20% of mucin-bound sialic acids are O-acetylated.	Sialic Acids	163-175	LOC100508689	Homo sapiens	21-26
9219830-5	1997	The O-acetylation of mucin-bound sialyl-Le(x) gradually decreased from N to M. HPLC analysis showed that in N about 70%, in T 45% and in M only 20% of mucin-bound sialic acids are O-acetylated.	Sialic Acids	163-175	LOC100508689	Homo sapiens	151-156
9166429-3	1997	Using a recombinant soluble form of the Influenza C virus hemagglutinin-esterase as a probe for 9-O-acetylated sialic acids, we demonstrate here their preferential expression on the CD4 T cell lineage in normal B10.A mouse lymphoid organs.	Sialic Acids	111-123	CD4 antigen	Mus musculus	182-185
9166429-10	1997	Digestions with trypsin and O-sialoglycoprotease (OSGPase) and ELISA studies of lipid extracts indicate that the 9-O-acetylated sialic acids on peripheral CD4 T cells are predominantly on O-linked mucintype glycoproteins and to a lesser degree, on sialylated glycolipids (gangliosides).	Sialic Acids	128-140	CD4 antigen	Mus musculus	155-158
9166429-11	1997	In contrast, sialic acids on mucin type molecules of CD8 T cells are not O-acetylated; instead these molecules mask the recognition of O-acetylated gangliosides that seem to be present at similar levels as on CD4 cells.	Sialic Acids	13-25	CD4 antigen	Mus musculus	209-212
9166429-15	1997	Thus, 9-O-acetylation of sialic acids on cell surface mucins is a novel marker on CD4 T cells that appears on maturation and is modulated downwards upon activation.	Sialic Acids	25-37	CD4 antigen	Mus musculus	82-85
9253768-1	1997	The ability of the influenza virus neuraminidase (NA) to cleave specific sialic acids was measured by cell electrophoresis.	Sialic Acids	73-85	neuraminidase 1	Homo sapiens	35-48
8985161-4	1996	Postulating that sialic acids on G-form molecules make it difficult for rCD59#77 to access nascent membrane attack complexes on the cell surface, the sialic acids were removed by neuraminidase treatment.	Sialic Acids	17-29	CD59 molecule	Rattus norvegicus	72-77
9148865-2	1997	The L-ALP from the sera of normal adults and various liver diseases was found to show different chromatographic behaviours on DSA affinity column with multiple peaks of ALP activity after the L-ALP was treated with neuraminidase to remove the terminal sialic acids on the sugar chain of L-ALP.	Sialic Acids	252-264	ATHS	Homo sapiens	6-9
9148865-2	1997	The L-ALP from the sera of normal adults and various liver diseases was found to show different chromatographic behaviours on DSA affinity column with multiple peaks of ALP activity after the L-ALP was treated with neuraminidase to remove the terminal sialic acids on the sugar chain of L-ALP.	Sialic Acids	252-264	ATHS	Homo sapiens	169-172
9148865-2	1997	The L-ALP from the sera of normal adults and various liver diseases was found to show different chromatographic behaviours on DSA affinity column with multiple peaks of ALP activity after the L-ALP was treated with neuraminidase to remove the terminal sialic acids on the sugar chain of L-ALP.	Sialic Acids	252-264	ATHS	Homo sapiens	169-172
9148865-2	1997	The L-ALP from the sera of normal adults and various liver diseases was found to show different chromatographic behaviours on DSA affinity column with multiple peaks of ALP activity after the L-ALP was treated with neuraminidase to remove the terminal sialic acids on the sugar chain of L-ALP.	Sialic Acids	252-264	neuraminidase 1	Homo sapiens	215-228
9148865-2	1997	The L-ALP from the sera of normal adults and various liver diseases was found to show different chromatographic behaviours on DSA affinity column with multiple peaks of ALP activity after the L-ALP was treated with neuraminidase to remove the terminal sialic acids on the sugar chain of L-ALP.	Sialic Acids	252-264	ATHS	Homo sapiens	169-172
9020110-7	1997	Most of these complex glycans are terminated with alpha-galactose residues, a consequence in bovine cells of the removal of terminal sialic acids by the viral neuraminidase.	Sialic Acids	133-145	neuraminidase 1	Bos taurus	159-172
8995428-12	1997	Mild periodate oxidation of sialic acids to their corresponding seven-carbon (or eight-carbon) sialic acid aldehydes abolished MAG binding, as did further conversion to the corresponding primary alcohols.	Sialic Acids	28-40	LOC103161439	Cricetulus griseus	127-130
8985161-4	1996	Postulating that sialic acids on G-form molecules make it difficult for rCD59#77 to access nascent membrane attack complexes on the cell surface, the sialic acids were removed by neuraminidase treatment.	Sialic Acids	150-162	CD59 molecule	Rattus norvegicus	72-77
8940168-12	1996	Indeed, the binding of human complement factor H, a negative regulator of the alternative pathway, is shown to be blocked by O-acetylation of the sialic acids on MEL cells.	Sialic Acids	146-158	complement factor H	Homo sapiens	29-48
9143414-6	1997	Removing the sialic acids from the MUC1 or CD43 mucins by sialidase treatment abolished the inhibitory effect.	Sialic Acids	13-25	mucin 1, cell surface associated	Homo sapiens	35-39
9143414-6	1997	Removing the sialic acids from the MUC1 or CD43 mucins by sialidase treatment abolished the inhibitory effect.	Sialic Acids	13-25	sialophorin	Homo sapiens	43-47
8986239-5	1996	These results indicate that the microheterogeneity of serum Tf in patients with ALD may be a more complex abnormality of elongation and processing on the glycans than merely a loss of terminal sialic acids.	Sialic Acids	193-205	transferrin	Homo sapiens	60-62
8662867-6	1996	The recombinant Bungarus AChE, like the natural venom enzyme, showed a distinctive ladder pattern in nondenaturing electrophoresis, probably reflecting a variation in the number of sialic acids.	Sialic Acids	181-193	acetylcholinesterase	Rattus norvegicus	25-29
8918804-6	1996	Given the importance of 9-O-acetylation of sialic acids, the cloning of the cDNA encoding a sialic acid-specific 9-O-acetylesterase will be helpful in understanding further the regulation of this post-translational modification and the biological consequences thereof.	Sialic Acids	43-55	sialic acid acetylesterase	Mus musculus	92-131
8812867-8	1996	The multiply charged kallikrein isoforms are derived from different numbers of sialic acids attached at the detected Asn-linked carbohydrates.	Sialic Acids	79-91	kallikrein related peptidase 4	Homo sapiens	21-31
8702582-1	1996	Kv1.1 potassium (K+) channels contain significant amounts of negatively charged sialic acids.	Sialic Acids	80-92	potassium voltage-gated channel subfamily A member 1	Rattus norvegicus	0-5
8642261-9	1996	Removal of terminal sialic acids with neuraminidase or protease treatment of cells abrogated cell adhesion to both selectin substrates.	Sialic Acids	20-32	neuraminidase 1	Homo sapiens	38-51
8625974-8	1996	The VAP-1 molecule induced in skin is decorated with abundant sialic acids.	Sialic Acids	62-74	amine oxidase copper containing 3	Homo sapiens	4-9
8727791-5	1996	As with Gly-CAM-1 synthesized by lymph node HEV, alpha 2-3 linked sialic acids and sulfation seem to play a critical role in generating this L-selectin binding.	Sialic Acids	66-78	selectin L	Homo sapiens	141-151
8627168-5	1996	The sialic acids are indispensable for the function of VAP-1, since the desialylated form of VAP-1 no longer mediates lymphocyte binding.	Sialic Acids	4-16	amine oxidase copper containing 3	Homo sapiens	55-60
8627168-5	1996	The sialic acids are indispensable for the function of VAP-1, since the desialylated form of VAP-1 no longer mediates lymphocyte binding.	Sialic Acids	4-16	amine oxidase copper containing 3	Homo sapiens	93-98
9172781-5	1996	High-pH anion-exchange chromatography with pulsed amperometric detection (HPAEC/PAD) analysis of sialic acids and oligosaccharides released from the two preparations of HST revealed that the two preparations differed in sialic acid and sialylated oligosaccharide content.	Sialic Acids	97-109	fibroblast growth factor 4	Homo sapiens	169-172
8590756-6	1995	The sensitivity of neurochordin D to neuraminidase suggests the presence of sialic acids.	Sialic Acids	76-88	neuraminidase 1	Homo sapiens	37-50
8556161-7	1995	By reversed-phase HPLC of tryptic digested neuraminidase treated rFVIIa the glycopeptides containing the heavy chain N-glycosylated site elute as two peaks compared to the four peaks corresponding to glycopeptides with 0 to 3 N-acetyl-neuraminic acids seen for untreated rFVIIa.	Sialic Acids	226-251	neuraminidase 1	Homo sapiens	43-56
22358930-3	1996	The enzyme was expressed efficiently, and resulted in up to 60% of the total sialic acids on interferon-gamma being linked in the alpha2,6-conformation.	Sialic Acids	77-89	interferon gamma	Cricetulus griseus	93-109
8748149-0	1995	Enzymatic transfer of sialic acids modified at C-5 employing four different sialyltransferases.	Sialic Acids	22-34	complement C5	Rattus norvegicus	47-50
8748149-2	1995	Biochemical properties of sialic acids were modified by introducing formyl-, trifluoroacetyl-, benzyloxy-carbonyl-, and aminoacetyl-groups to the amino group at C-5 of neuraminic acid.	Sialic Acids	26-38	complement C5	Rattus norvegicus	161-164
7592484-6	1995	Enzyme assays demonstrated that ORF-1 did not possess sialyltransferase activity but mimicked GlmU function catalyzing the conversion of N-acetylglucosamine 1-phosphate into UDP-N-acetylglucosamine, which is a key metabolite in the syntheses of lipopolysaccharide, peptidoglycan, and sialic acids.	Sialic Acids	284-296	hypothetical protein	Escherichia coli	32-37
7539263-0	1995	Access to peptide regions of a surface mucin (MUC1) is reduced by sialic acids.	Sialic Acids	66-78	LOC100508689	Homo sapiens	39-44
7589075-13	1995	Thus, in cultured endothelial cells, VAP-1 is a 180-kDa protein which is devoid of post-translational modifications, and in particular, lacks the sialic acids crucial for the function of VAP-1 in tonsil vessels.	Sialic Acids	146-158	amine oxidase copper containing 3	Homo sapiens	37-42
7589075-6	1995	In tonsil HEV, VAP-1 is modified with abundant sialic acids.	Sialic Acids	47-59	amine oxidase copper containing 3	Homo sapiens	15-20
7627976-4	1995	Removal of most of the sialic acids from SW1990 mucins by neuraminidase greatly enhanced binding of two other MUC1 peptide specific antibodies, HMFG-2 and SM-3.	Sialic Acids	23-35	neuraminidase 1	Homo sapiens	58-71
7627976-4	1995	Removal of most of the sialic acids from SW1990 mucins by neuraminidase greatly enhanced binding of two other MUC1 peptide specific antibodies, HMFG-2 and SM-3.	Sialic Acids	23-35	mucin 1, cell surface associated	Homo sapiens	110-114
7627976-7	1995	Moreover, sialic acids play an important role in determining the net negative charge of sialyl-Lewis(a) and sialyl-Lewis(x) rich mucins and in obscuring MUC1 peptide regions.	Sialic Acids	10-22	mucin 1, cell surface associated	Homo sapiens	153-157
7539263-0	1995	Access to peptide regions of a surface mucin (MUC1) is reduced by sialic acids.	Sialic Acids	66-78	mucin 1, cell surface associated	Homo sapiens	46-50
7757221-8	1995	In particular, sialic acids are present in the structure of the cellular receptors for insulin.	Sialic Acids	15-27	insulin	Homo sapiens	87-94
7706300-10	1995	Since B lymphoma cells themselves also express high levels of alpha 2-6-linked sialic acids, their CD22 molecules might be rendered nonfunctional by endogenous ligands.	Sialic Acids	79-91	CD22 molecule	Homo sapiens	99-103
7875291-5	1995	N-Glycanase treatment and linkage-specific sialidase treatment of glycoproteins revealed that STX transfers sialic acids through alpha 2,8-linkages to only N-linked oligosaccharides of glycoproteins.	Sialic Acids	108-120	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Mus musculus	94-97
8034751-0	1994	Natural ligands of the B cell adhesion molecule CD22 beta can be masked by 9-O-acetylation of sialic acids.	Sialic Acids	94-106	CD22 antigen	Mus musculus	48-52
7742784-2	1995	Since sialic acids at the terminal of the carbohydrate chains bound to fibrinogen are part of the low affinity calcium binding site necessary for polymerization, they are closely involved in the network structure of fibrin clots.	Sialic Acids	6-18	fibrinogen beta chain	Homo sapiens	71-81
7696861-0	1994	Modifications of cell surface sialic acids modulate cell adhesion mediated by sialoadhesin and CD22.	Sialic Acids	30-42	sialic acid binding Ig like lectin 1	Homo sapiens	78-90
7696861-0	1994	Modifications of cell surface sialic acids modulate cell adhesion mediated by sialoadhesin and CD22.	Sialic Acids	30-42	CD22 molecule	Homo sapiens	95-99
7696861-1	1994	An increasing number of mammalian cell adhesion molecules, including sialoadhesion, CD22 and the family of selectins, have been found to bind cell surface glycoconjugates containing sialic acids.	Sialic Acids	182-194	CD22 molecule	Homo sapiens	84-88
7696861-5	1994	Of two synthetic sialic acids tested, only CD22 bound the N-formyl derivative, whereas a N-trifluoroacetyl residue was accepted by sialoadhesin.	Sialic Acids	17-29	CD22 molecule	Homo sapiens	43-47
7955382-2	1994	The predominant Tf C1 allele encodes a protein for which the most prevalent isoform has a pI of 5.4, i.e., four sialic acids and two bound ion molecules.	Sialic Acids	112-124	transferrin	Homo sapiens	16-18
8034751-13	1994	Thus, 9-O-acetylation of sialic acids on immune cells is in a position to negatively regulate CD22 beta adhesion events in a manner depending on both cell type and tissue localization.	Sialic Acids	25-37	CD22 antigen	Mus musculus	94-98
7506656-7	1993	Sialic acids were linked predominantly through alpha 2-6 linkages, although alpha 2-3 linkages were also present, and fucose was linked to the innermost N-acetylglucosamine through an alpha 1-6 linkage.	Sialic Acids	0-12	immunoglobulin binding protein 1	Homo sapiens	47-56
8185161-12	1994	The bovine CCKA receptor is of apparent size M(r) = 70-85 kD with N-linked complex carbohydrates and sialic acids.	Sialic Acids	101-113	cholecystokinin A receptor	Rattus norvegicus	11-24
8474169-5	1993	The virus also was treated with neuraminidase or endo-beta-galactosidase to remove terminal sialic acids.	Sialic Acids	92-104	galactosidase beta 1	Homo sapiens	54-72
8288440-5	1993	This review emphasizes the following characteristics of epsilon BP: (i) epsilon BP is secreted by cells such as macrophages; (ii) like many other lectins, epsilon BP functions at least bivalently; (iii) epsilon BP has specificity for distinct oligosaccharide structures that have a terminal galactose not masked by sialic acids; and (iv) in addition to binding IgE, epsilon BP binds to surfaces of various cell types via lectin-carbohydrate interaction.	Sialic Acids	315-327	galectin 3	Rattus norvegicus	56-66
8288440-5	1993	This review emphasizes the following characteristics of epsilon BP: (i) epsilon BP is secreted by cells such as macrophages; (ii) like many other lectins, epsilon BP functions at least bivalently; (iii) epsilon BP has specificity for distinct oligosaccharide structures that have a terminal galactose not masked by sialic acids; and (iv) in addition to binding IgE, epsilon BP binds to surfaces of various cell types via lectin-carbohydrate interaction.	Sialic Acids	315-327	galectin 3	Rattus norvegicus	72-82
8288440-5	1993	This review emphasizes the following characteristics of epsilon BP: (i) epsilon BP is secreted by cells such as macrophages; (ii) like many other lectins, epsilon BP functions at least bivalently; (iii) epsilon BP has specificity for distinct oligosaccharide structures that have a terminal galactose not masked by sialic acids; and (iv) in addition to binding IgE, epsilon BP binds to surfaces of various cell types via lectin-carbohydrate interaction.	Sialic Acids	315-327	galectin 3	Rattus norvegicus	72-82
8288440-5	1993	This review emphasizes the following characteristics of epsilon BP: (i) epsilon BP is secreted by cells such as macrophages; (ii) like many other lectins, epsilon BP functions at least bivalently; (iii) epsilon BP has specificity for distinct oligosaccharide structures that have a terminal galactose not masked by sialic acids; and (iv) in addition to binding IgE, epsilon BP binds to surfaces of various cell types via lectin-carbohydrate interaction.	Sialic Acids	315-327	galectin 3	Rattus norvegicus	72-82
8288440-5	1993	This review emphasizes the following characteristics of epsilon BP: (i) epsilon BP is secreted by cells such as macrophages; (ii) like many other lectins, epsilon BP functions at least bivalently; (iii) epsilon BP has specificity for distinct oligosaccharide structures that have a terminal galactose not masked by sialic acids; and (iv) in addition to binding IgE, epsilon BP binds to surfaces of various cell types via lectin-carbohydrate interaction.	Sialic Acids	315-327	galectin 3	Rattus norvegicus	72-82
7685350-7	1993	Here, we demonstrate that this P-selectin ligand carries alpha 2-3-linked sialic acids and the sialyl-Lewisx (SLex) tetrasaccharide motif.	Sialic Acids	74-86	selectin P	Homo sapiens	31-41
8512075-3	1993	Incubation of r-HuEPO with neuraminidase caused the slowest migrating species to diminish first in response, indicating that these contained the highest numbers of sialic acids.	Sialic Acids	164-176	neuraminidase 1	Homo sapiens	27-40
8449944-3	1993	On chromatofocusing, CDG syndrome transferrin was separated into three major isoforms, S4, S2, and S0, containing 4, 2, and 0 sialic acids/molecule at pH 5.12 (5.16), 5.42, and 5.80, respectively.	Sialic Acids	126-138	transferrin	Homo sapiens	34-45
8463234-4	1993	CD22-mediated adhesion is dependent upon the presence of sialic acids on ligands.	Sialic Acids	57-69	CD22 molecule	Homo sapiens	0-4
8463234-7	1993	Direct binding of CD22Rg to lymphoid cells also requires sialic acids and their side chains.	Sialic Acids	57-69	CD22 molecule	Homo sapiens	18-22
8358227-4	1993	Glycoproteins like fetuin and saponified bovine submandibular gland mucin, most of them having alpha(2-6) linked sialic acids, are preferred substrates, while sialic acids from gangliosides, sialyllactoses, or the alpha(2-8) linked sialic acid polymer (colominic acid) are hydrolysed at lower rates.	Sialic Acids	113-125	mucin 1, cell surface associated	Bos taurus	68-73
8444846-3	1993	Desialylation of Lp(a) dramatically decreased the ability of Lp(a) to aggregate, suggesting that sialic acids on Lp(a) were responsible for forming Ca2+ cross-bridges.	Sialic Acids	97-109	lipoprotein(a)	Homo sapiens	17-22
8444846-3	1993	Desialylation of Lp(a) dramatically decreased the ability of Lp(a) to aggregate, suggesting that sialic acids on Lp(a) were responsible for forming Ca2+ cross-bridges.	Sialic Acids	97-109	lipoprotein(a)	Homo sapiens	61-66
8444846-3	1993	Desialylation of Lp(a) dramatically decreased the ability of Lp(a) to aggregate, suggesting that sialic acids on Lp(a) were responsible for forming Ca2+ cross-bridges.	Sialic Acids	97-109	lipoprotein(a)	Homo sapiens	61-66
8444846-4	1993	Since a reduction of only 30% of the sialic acids on Lp(a) inhibited Ca(2+)-induced complex formation, it appears that only a small percentage of sialic acids on Lp(a) is involved in Ca(2+)-induced cross-bridging of Lp(a) particles.	Sialic Acids	37-49	lipoprotein(a)	Homo sapiens	53-58
8444846-4	1993	Since a reduction of only 30% of the sialic acids on Lp(a) inhibited Ca(2+)-induced complex formation, it appears that only a small percentage of sialic acids on Lp(a) is involved in Ca(2+)-induced cross-bridging of Lp(a) particles.	Sialic Acids	146-158	lipoprotein(a)	Homo sapiens	162-167
8444846-4	1993	Since a reduction of only 30% of the sialic acids on Lp(a) inhibited Ca(2+)-induced complex formation, it appears that only a small percentage of sialic acids on Lp(a) is involved in Ca(2+)-induced cross-bridging of Lp(a) particles.	Sialic Acids	146-158	lipoprotein(a)	Homo sapiens	162-167
8358227-4	1993	Glycoproteins like fetuin and saponified bovine submandibular gland mucin, most of them having alpha(2-6) linked sialic acids, are preferred substrates, while sialic acids from gangliosides, sialyllactoses, or the alpha(2-8) linked sialic acid polymer (colominic acid) are hydrolysed at lower rates.	Sialic Acids	159-171	mucin 1, cell surface associated	Bos taurus	68-73
1616876-5	1992	It is not clear whether rat CBG contains a carbohydrate structure with sialic acids attached to both galactose and N-acetylglucosamine on the same antenna, or a terminal disialylated structure (sialic acid linked alpha 2-8 to sialic acid).	Sialic Acids	71-83	serpin family A member 6	Rattus norvegicus	28-31
7679216-0	1993	Enhanced interaction of L-selectin with the high endothelial venule ligand via selectively oxidized sialic acids.	Sialic Acids	100-112	selectin L	Homo sapiens	24-34
1378032-5	1992	These data suggest that at least a part of the structural basis for the difference between the serum levels of antigen MUSE11 and CA15-3 could be carbohydrate side chains including sialic acids.	Sialic Acids	181-193	mucin 1, cell surface associated	Homo sapiens	130-136
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	Sialic Acids	0-12	LOC100508689	Homo sapiens	97-102
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	Sialic Acids	0-12	LOC100508689	Homo sapiens	146-151
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	Sialic Acids	0-12	LOC100508689	Homo sapiens	146-151
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	Sialic Acids	195-207	LOC100508689	Homo sapiens	97-102
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	Sialic Acids	195-207	LOC100508689	Homo sapiens	146-151
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	Sialic Acids	195-207	LOC100508689	Homo sapiens	146-151
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	Sialic Acids	272-284	LOC100508689	Homo sapiens	97-102
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	Sialic Acids	272-284	LOC100508689	Homo sapiens	146-151
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	Sialic Acids	272-284	LOC100508689	Homo sapiens	146-151
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	Sialic Acids	272-284	LOC100508689	Homo sapiens	97-102
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	Sialic Acids	272-284	LOC100508689	Homo sapiens	146-151
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	Sialic Acids	272-284	LOC100508689	Homo sapiens	146-151
1398908-8	1992	We conclude that the presence of two or more O-acetyl groups on sialic acids inhibits enteric bacterial sialidases but that production of sialate O-acetylesterases by several populations of enteric bacteria lessens the likelihood that mucin oligosaccharide chains terminating in O-acetylated sialic acids are protected from degradation.	Sialic Acids	292-304	LOC100508689	Homo sapiens	235-240
1591399-6	1992	A decrease in mass by neuraminidase digestion, however, determined the average number of sialic acids in the molecule.	Sialic Acids	89-101	neuraminidase 1	Homo sapiens	22-35
1560005-7	1992	The in vitro activity and the affinity also correlated with the number of sialic acids bound to the deglycosylated hEPO preparations.	Sialic Acids	74-86	erythropoietin	Homo sapiens	115-119
1661839-6	1991	Treatment of the purified protein with neuraminidase reduced the apparent molecular weight by 9000, indicating the presence of terminal sialic acids on the oligosaccharide portion of this molecule.	Sialic Acids	136-148	neuraminidase 1	Bos taurus	39-52
1841675-6	1991	In addition, the proportion of di-O-acetylated sialic acids was higher in the major mucin.	Sialic Acids	47-59	mucin 1, cell surface associated	Bos taurus	84-89
1761628-4	1991	rtPA was treated with neuraminidase which removes the sialic acids from the carbohydrate chains.	Sialic Acids	54-66	neuraminidase 1	Homo sapiens	22-35
1713644-7	1991	Selective enzymatic removal of sialic acid showed that +A.FN had both sialic acids in an alpha 2----3 linkage, whereas -A.FN apparently had one alpha 2----3 and one alpha 2----6-linked sialic acid.	Sialic Acids	70-82	fibronectin 1	Rattus norvegicus	58-60
1651042-5	1991	Mucin histochemistry revealed the presence of O-acylated and non-O-acylated sialic acids in both neoplastic goblet cells in the adenocarcinomas and Paget cells in the anal mucosa.	Sialic Acids	76-88	LOC100508689	Homo sapiens	0-5
2124546-1	1990	HPLC analysis of sialic acids released from recombinant variants of human tissue plasminogen activator, human chimeric plasminogen activator, human erythropoietin, and human follitropin, expressed in Chinese hamster ovary cells, demonstrates for each glycoprotein the presence of N-acetylneuraminic acid and N-glycolylneuraminic acid in a ratio of 97:3.	Sialic Acids	17-29	chromosome 20 open reading frame 181	Homo sapiens	74-102
1725500-1	1991	Agglutination of human erythrocytes by the lectin concanavalin A is enhanced when the erythrocytes are pretreated with neuraminidase, which removes sialic acids, or with pronase, which degrades both the glycophorins and band 3 protein.	Sialic Acids	148-160	neuraminidase 1	Homo sapiens	119-132
2041217-1	1991	Sialic acids, derivatives of neuraminic acid, are present as structural components of mucoprotein mainly in the alpha 1 and alpha 2-globulin regions, and they are known to change in diseases associated with acute inflammation or tissue necrosis.	Sialic Acids	0-12	adrenoceptor alpha 1D	Homo sapiens	112-131
2269277-7	1990	Partially or fully de-N-glycosylated erythropoietin derivatives also showed lower in vivo activity but higher in vitro activity than the intact erythropoietin, dependent on the number of sialic acids.	Sialic Acids	187-199	erythropoietin	Homo sapiens	37-51
2269277-7	1990	Partially or fully de-N-glycosylated erythropoietin derivatives also showed lower in vivo activity but higher in vitro activity than the intact erythropoietin, dependent on the number of sialic acids.	Sialic Acids	187-199	erythropoietin	Homo sapiens	144-158
1999142-9	1991	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the glycosidase-treated receptor-[125I]hCG complex also revealed that neuraminidase was able to remove the sialic acids from both subunits of the receptor-bound hormone.	Sialic Acids	177-189	chorionic gonadotropin subunit beta 5	Homo sapiens	109-112
1999142-9	1991	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the glycosidase-treated receptor-[125I]hCG complex also revealed that neuraminidase was able to remove the sialic acids from both subunits of the receptor-bound hormone.	Sialic Acids	177-189	neuraminidase 1	Homo sapiens	140-153
1702721-6	1990	Furthermore, treatment of CD45 proteins with O-glycanase or neuraminidase resulted in the loss of both CD45R0 and CD45RB epitopes, although reactivity of the anti-CD45R0 and anti-CD45RB mAb was not affected by mAb preincubation with either sialic acids or sialyllactose in solution.	Sialic Acids	240-252	protein tyrosine phosphatase receptor type C	Homo sapiens	26-30
1702721-6	1990	Furthermore, treatment of CD45 proteins with O-glycanase or neuraminidase resulted in the loss of both CD45R0 and CD45RB epitopes, although reactivity of the anti-CD45R0 and anti-CD45RB mAb was not affected by mAb preincubation with either sialic acids or sialyllactose in solution.	Sialic Acids	240-252	neuraminidase 1	Homo sapiens	60-73
33763070-0	2021	Interplay Between Sialic Acids, Siglec-E, and Neu1 Regulates MyD88- and TRIF-Dependent Pathways for TLR4-Activation During Leishmania donovani Infection.	Sialic Acids	18-30	toll-like receptor 4	Mus musculus	100-104
2153181-3	1990	The data suggest that SA11 rotavirus binds to a specific sialic acid structure on BSM different from the sialic acids recognized by other viruses.	Sialic Acids	105-117	mucin-19	Bos taurus	82-85
2156701-12	1990	Thus resistance of erythropoietin to thermal inactivation is largely due to the presence of sugars, and terminal sialic acids greatly contribute to the stability.	Sialic Acids	113-125	erythropoietin	Homo sapiens	19-33
2138034-5	1990	Removal of sialic acids from SAP reduced the calcium-dependent binding activity for agarose by 7%, suggesting the terminal sialic acids were partially responsible for the binding.	Sialic Acids	11-23	amyloid P component, serum	Homo sapiens	29-32
2138034-5	1990	Removal of sialic acids from SAP reduced the calcium-dependent binding activity for agarose by 7%, suggesting the terminal sialic acids were partially responsible for the binding.	Sialic Acids	123-135	amyloid P component, serum	Homo sapiens	29-32
33763070-7	2021	Such sialic acids-siglec-E interaction enhanced siglec-E phosphorylation that mediated its strong association with SHP1/SHP2 and also upregulated their phosphorylation in both types of macrophages.	Sialic Acids	5-17	sialic acid binding Ig-like lectin E	Mus musculus	18-26
33763070-7	2021	Such sialic acids-siglec-E interaction enhanced siglec-E phosphorylation that mediated its strong association with SHP1/SHP2 and also upregulated their phosphorylation in both types of macrophages.	Sialic Acids	5-17	sialic acid binding Ig-like lectin E	Mus musculus	48-56
33763070-9	2021	Moreover, a reciprocal interplay between Neu1 and siglec-E differentially regulates MyD88- and TRIF-pathways through sialic acids on TLR4 as their common substrate during infection.	Sialic Acids	117-129	neuraminidase 1	Mus musculus	41-45
33763070-9	2021	Moreover, a reciprocal interplay between Neu1 and siglec-E differentially regulates MyD88- and TRIF-pathways through sialic acids on TLR4 as their common substrate during infection.	Sialic Acids	117-129	sialic acid binding Ig-like lectin E	Mus musculus	50-58
33763070-9	2021	Moreover, a reciprocal interplay between Neu1 and siglec-E differentially regulates MyD88- and TRIF-pathways through sialic acids on TLR4 as their common substrate during infection.	Sialic Acids	117-129	toll-like receptor 4	Mus musculus	133-137
33763070-16	2021	All these significantly inhibited parasite survival in macrophages thus demonstrating a previously unidentified dualistic regulation of TLR4signaling pathways activation through sialic acids by interplay of Neu1 and siglec-E during Leishmania infection.	Sialic Acids	178-190	neuraminidase 1	Mus musculus	207-211
33763070-16	2021	All these significantly inhibited parasite survival in macrophages thus demonstrating a previously unidentified dualistic regulation of TLR4signaling pathways activation through sialic acids by interplay of Neu1 and siglec-E during Leishmania infection.	Sialic Acids	178-190	sialic acid binding Ig-like lectin E	Mus musculus	216-224
34641547-5	2021	An increased ratio of isomers with more alpha-2,6-linked sialic acids was also observed.	Sialic Acids	57-69	glycoprotein hormone subunit alpha 2	Homo sapiens	40-47
34662214-4	2022	One hypothesis is that Salmonella can alter the electrical properties of the macrophages by modifying host cell surface glycan composition, which is supported by the fact that cleavage of surface-exposed sialic acids with a bacterial neuraminidase severely impairs macrophage galvanotaxis, as well as phagocytosis.	Sialic Acids	204-216	neuraminidase 1	Homo sapiens	234-247
34669428-12	2022	Using nanoparticles-displaying VP2 to probe a glycan array, we identified that VP2 binds both alpha2,3-linked and alpha2,6-linked sialic acids.	Sialic Acids	130-142	glycoprotein hormone subunit alpha 2	Homo sapiens	114-120
34506921-2	2021	Recent evidence suggests that along with angiotensin converting enzyme 2, certain cell surface sialic acids (Sia) may function as receptors for binding SARS-CoV-2 spike protein.	Sialic Acids	95-107	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	163-168
34687617-1	2021	Polysialic acid (polySia) is a linear homopolymer of alpha2-8-linked sialic acids that is highly expressed during early stages of mammalian brain development and modulates a multitude of cellular functions.	Sialic Acids	69-81	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	53-61
34494938-5	2021	Enveloped viruses for example have been shown to manipulate Siglec-1 to increase their virulence by binding to sialic acids present on the virus glycoproteins allowing them to spread or evade immune response.	Sialic Acids	111-123	sialic acid binding Ig like lectin 1	Homo sapiens	60-68
34572394-4	2021	Sialic acids binding to the N-terminal domain of the Spike protein are known to be crucial for viral entry into humans, and the role of Galectin-3 as a mediator of lung fibrosis has long been the object of study since its levels have been found to be abnormally high in alveolar macrophages following lung injury.	Sialic Acids	0-12	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	53-58
34572394-4	2021	Sialic acids binding to the N-terminal domain of the Spike protein are known to be crucial for viral entry into humans, and the role of Galectin-3 as a mediator of lung fibrosis has long been the object of study since its levels have been found to be abnormally high in alveolar macrophages following lung injury.	Sialic Acids	0-12	galectin 3	Homo sapiens	136-146
34157283-2	2021	The 9-carbon backbone of sialic acids can undergo extensive enzymatic modification in nature and O-acetylation at the C-4/7/8/9 position in particular is widely observed.	Sialic Acids	25-37	complement C4A (Rodgers blood group)	Homo sapiens	118-127
34328657-6	2021	In addition, we show that CD44 is modified by alpha2,6-linked sialic acids on N-glycans in hepatoma cells, and that CD44 sialylation affects its interaction with Siglec-15.	Sialic Acids	62-74	CD44 molecule (Indian blood group)	Homo sapiens	26-30
34282273-0	2021	NEU4 inhibits motility of HCC cells by cleaving sialic acids on CD44.	Sialic Acids	48-60	sialidase 4	Mus musculus	0-4
34282273-0	2021	NEU4 inhibits motility of HCC cells by cleaving sialic acids on CD44.	Sialic Acids	48-60	CD44 antigen	Mus musculus	64-68
34282273-3	2021	NEU4 is a sialidase that removes SAs from glycoconjugates, while the function of the NEU4 in HCC has not been clearly explored.	Sialic Acids	33-36	sialidase 4	Mus musculus	0-4
34368076-0	2021	Identification of Potential Binding Sites of Sialic Acids on the RBD Domain of SARS-CoV-2 Spike Protein.	Sialic Acids	45-57	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	90-95
34368076-4	2021	SARS-CoV-2 shares similar sequences of the spike protein with the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), which can invade host cells by binding to either DPP4 or sialic acids.	Sialic Acids	180-192	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	43-48
34368076-9	2021	This study shows that sialic acids can moderately interact with the spike protein of SARS-CoV-2 by binding between the two RBDs of the spike protein, indicating it could be a potential secondary or auxiliary receptor of SARS-CoV-2.	Sialic Acids	22-34	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	68-73
34368076-9	2021	This study shows that sialic acids can moderately interact with the spike protein of SARS-CoV-2 by binding between the two RBDs of the spike protein, indicating it could be a potential secondary or auxiliary receptor of SARS-CoV-2.	Sialic Acids	22-34	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	135-140
34197564-8	2021	We also show that viral NA acts on the heavily sialylated DAF and propose that the NA-dependent DAF removal of sialic acids exacerbates complement activation, leading to lung immunopathology.	Sialic Acids	111-123	CD55 molecule (Cromer blood group)	Homo sapiens	58-61
34292679-1	2021	Sialic acids (SA) determine the degree of molecular hydrophilia, relieve binding together and their transportation, they increase mucin viscosity, stabilize the protein and membrane structure.	Sialic Acids	0-12	LOC100508689	Homo sapiens	130-135
34292679-1	2021	Sialic acids (SA) determine the degree of molecular hydrophilia, relieve binding together and their transportation, they increase mucin viscosity, stabilize the protein and membrane structure.	Sialic Acids	14-16	LOC100508689	Homo sapiens	130-135
34197564-8	2021	We also show that viral NA acts on the heavily sialylated DAF and propose that the NA-dependent DAF removal of sialic acids exacerbates complement activation, leading to lung immunopathology.	Sialic Acids	111-123	CD55 molecule (Cromer blood group)	Homo sapiens	96-99
35581157-2	2022	Modification of sialic acids with O-acetyl esters is known to protect mucin glycans from degradation by bacterial sialidases.	Sialic Acids	16-28	mucin 1, cell surface associated	Bos taurus	70-75
34188220-1	2021	NEU1 sialidase hydrolyzes sialic acids from glycoconjugates in lysosomes.	Sialic Acids	26-38	neuraminidase 1	Danio rerio	0-4
35272171-2	2022	Targeting CSCs with dendritic cell (DC)-based vaccines have been an effective strategy, but sialic acids on the surface of DCs limit the interaction with loaded antigens.	Sialic Acids	92-104	decorin	Mus musculus	36-38
35371997-3	2022	The sialyltransferase ST6Gal1, with high expression in specific hematopoietic cell types, is the only enzyme thought to catalyze the terminal addition of sialic acids in an alpha2-6-linkage to galactose on N-glycans in such cells.	Sialic Acids	154-166	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	22-29
35326703-10	2022	We observed changes in the cancer invasive front, including higher expression of alpha2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region.	Sialic Acids	97-109	immunoglobulin kappa variable 2-24	Homo sapiens	81-89
35191576-0	2022	The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids:  A NMR View.	Sialic Acids	60-72	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	15-20
35191576-2	2022	The NMR-based distinction between the signals of those sialic acids in the glycans covalently attached to the spike protein and those belonging to the exogenous a2,3 and a2,6 sialyl N-Acetyllactosamine ligands has been achieved by synthesizing uniformly 13C-labelled trisaccharides at the sialic acid and galactose moieties.	Sialic Acids	55-67	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	110-115
35371997-3	2022	The sialyltransferase ST6Gal1, with high expression in specific hematopoietic cell types, is the only enzyme thought to catalyze the terminal addition of sialic acids in an alpha2-6-linkage to galactose on N-glycans in such cells.	Sialic Acids	154-166	calmegin	Mus musculus	173-181
35221292-1	2022	Sialic acids (SA) are derivatives of neuraminic acid; they are located at the terminal position in the chains of monosaccharide residues of various glycoconjugates.	Sialic Acids	0-12	acyl-CoA synthetase medium chain family member 3	Homo sapiens	14-16
35052006-1	2022	The GNE gene encodes an enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid, a precursor of sialic acids.	Sialic Acids	120-132	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	4-7
35014832-1	2022	Human neuraminidase 1 (NEU1) is a lysosomal glycosidase that cleaves the terminal sialic acids of sialylglycoconjugates.	Sialic Acids	82-94	neuraminidase 1	Homo sapiens	6-21
35014832-1	2022	Human neuraminidase 1 (NEU1) is a lysosomal glycosidase that cleaves the terminal sialic acids of sialylglycoconjugates.	Sialic Acids	82-94	neuraminidase 1	Homo sapiens	23-27
35014832-5	2022	In this study, we first purified the NEU1 from the isolated crystals produced by the HEK293 NEU1-KO cell transiently overexpressing the normal NEU1 and found that the N-glycans were high-mannose or complex types carrying terminal sialic acids.	Sialic Acids	230-242	neuraminidase 1	Homo sapiens	37-41
35014832-5	2022	In this study, we first purified the NEU1 from the isolated crystals produced by the HEK293 NEU1-KO cell transiently overexpressing the normal NEU1 and found that the N-glycans were high-mannose or complex types carrying terminal sialic acids.	Sialic Acids	230-242	neuraminidase 1	Homo sapiens	92-96
35014832-5	2022	In this study, we first purified the NEU1 from the isolated crystals produced by the HEK293 NEU1-KO cell transiently overexpressing the normal NEU1 and found that the N-glycans were high-mannose or complex types carrying terminal sialic acids.	Sialic Acids	230-242	neuraminidase 1	Homo sapiens	143-147
35041670-3	2022	Hence, this paper outlines a simple method to detect and quantify sialic acids in cancer cells for evaluating sialyltransferase activity of potential therapeutic compounds.	Sialic Acids	66-78	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	110-127