PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29098062-4	2017	We found that both the SMUG1 protein and the TDG protein exhibit DNA glycosylase activity against thymine mispaired with 8BrG and that the MUTYH protein exhibits DNA glycosylase activity against adenine mispaired with 8BrG.	8-bromoguanine	121-125	single-strand-selective monofunctional uracil-DNA glycosylase 1	Homo sapiens	23-28
29098062-4	2017	We found that both the SMUG1 protein and the TDG protein exhibit DNA glycosylase activity against thymine mispaired with 8BrG and that the MUTYH protein exhibits DNA glycosylase activity against adenine mispaired with 8BrG.	8-bromoguanine	121-125	thymine DNA glycosylase	Homo sapiens	45-48
29098062-4	2017	We found that both the SMUG1 protein and the TDG protein exhibit DNA glycosylase activity against thymine mispaired with 8BrG and that the MUTYH protein exhibits DNA glycosylase activity against adenine mispaired with 8BrG.	8-bromoguanine	121-125	mutY DNA glycosylase	Homo sapiens	139-144
29098062-4	2017	We found that both the SMUG1 protein and the TDG protein exhibit DNA glycosylase activity against thymine mispaired with 8BrG and that the MUTYH protein exhibits DNA glycosylase activity against adenine mispaired with 8BrG.	8-bromoguanine	218-222	single-strand-selective monofunctional uracil-DNA glycosylase 1	Homo sapiens	23-28
29098062-4	2017	We found that both the SMUG1 protein and the TDG protein exhibit DNA glycosylase activity against thymine mispaired with 8BrG and that the MUTYH protein exhibits DNA glycosylase activity against adenine mispaired with 8BrG.	8-bromoguanine	218-222	thymine DNA glycosylase	Homo sapiens	45-48
29098062-4	2017	We found that both the SMUG1 protein and the TDG protein exhibit DNA glycosylase activity against thymine mispaired with 8BrG and that the MUTYH protein exhibits DNA glycosylase activity against adenine mispaired with 8BrG.	8-bromoguanine	218-222	mutY DNA glycosylase	Homo sapiens	139-144
17090545-8	2007	We also investigated the kinetic mechanism of OGG1 stimulation by 8-bromoguanine and showed that this compound affects the rate of beta-elimination rather than pre-excision dynamics of DNA and the enzyme.	8-bromoguanine	66-80	8-oxoguanine DNA glycosylase	Homo sapiens	46-50
24425881-3	2014	To gain insights into the mechanism of misincorporation across haloG by polymerase, we determined seven x-ray structures of human DNA polymerase beta (polbeta) bound to DNA bearing 8-bromoguanine (BrG).	8-bromoguanine	181-195	DNA polymerase beta	Homo sapiens	130-149
24425881-3	2014	To gain insights into the mechanism of misincorporation across haloG by polymerase, we determined seven x-ray structures of human DNA polymerase beta (polbeta) bound to DNA bearing 8-bromoguanine (BrG).	8-bromoguanine	197-200	DNA polymerase beta	Homo sapiens	130-149
23955443-7	2013	Both mutants were notably stimulated in the presence of free 8-bromoguanine, indicating that this base can bind to the distorted OGG1 and facilitate beta-elimination.	8-bromoguanine	61-75	8-oxoguanine DNA glycosylase	Homo sapiens	129-133
11361142-3	2001	Guanine, 8-hydroxyguanine, 8-methylguanine, and 8-bromoguanine inhibited the enzyme activity in a GFRP-dependent and pH-dependent manner and induced complex formation between GTP cyclohydrolase I and GFRP.	8-bromoguanine	48-62	GTP cyclohydrolase I feedback regulator	Homo sapiens	98-102
11361142-3	2001	Guanine, 8-hydroxyguanine, 8-methylguanine, and 8-bromoguanine inhibited the enzyme activity in a GFRP-dependent and pH-dependent manner and induced complex formation between GTP cyclohydrolase I and GFRP.	8-bromoguanine	48-62	GTP cyclohydrolase 1	Homo sapiens	175-195
11361142-3	2001	Guanine, 8-hydroxyguanine, 8-methylguanine, and 8-bromoguanine inhibited the enzyme activity in a GFRP-dependent and pH-dependent manner and induced complex formation between GTP cyclohydrolase I and GFRP.	8-bromoguanine	48-62	GTP cyclohydrolase I feedback regulator	Homo sapiens	200-204
16024742-7	2005	hOgg1 interacted with a substrate containing an aldehydic AP site very slowly, but the addition of 8-bromoguanine (8-BrG) greatly accelerated the reaction, which was best described by two initial equilibrium steps followed by one irreversible chemical step and a final product release equilibrium step.	8-bromoguanine	115-120	8-oxoguanine DNA glycosylase	Homo sapiens	0-5