PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3262523-8	1988	The data indicate a specific interaction between retinoid acid and EGF which results in the potentiation of the EGF-stimulated cell growth.	retinoid acid	49-62	epidermal growth factor	Homo sapiens	67-70
3262523-8	1988	The data indicate a specific interaction between retinoid acid and EGF which results in the potentiation of the EGF-stimulated cell growth.	retinoid acid	49-62	epidermal growth factor	Homo sapiens	112-115
33176587-1	2021	A transgenic Acute Promyelocytic Leukemia (APL) murine model established by Michael Bishop by cloning a human PML-RARalpha cDNA into the hMRP8 expression cassette has been widely used in the all-trans retinoid acid and arsenic preparations for the research of APL.	retinoid acid	201-214	S100 calcium binding protein A8	Homo sapiens	137-142
33351133-0	2020	IGFBP7 activates retinoid acid-induced responses in acute myeloid leukemia stem and progenitor cells.	retinoid acid	17-30	insulin like growth factor binding protein 7	Homo sapiens	0-6
32865619-0	2020	Protein Kinase C Alpha (PKCalpha) overexpression leads to a better response to retinoid acid therapy through Retinoic Acid Receptor Beta (RARbeta) activation in mammary cancer cells.	retinoid acid	79-92	protein kinase C alpha	Homo sapiens	0-22
32865619-0	2020	Protein Kinase C Alpha (PKCalpha) overexpression leads to a better response to retinoid acid therapy through Retinoic Acid Receptor Beta (RARbeta) activation in mammary cancer cells.	retinoid acid	79-92	protein kinase C alpha	Homo sapiens	24-32
32865619-0	2020	Protein Kinase C Alpha (PKCalpha) overexpression leads to a better response to retinoid acid therapy through Retinoic Acid Receptor Beta (RARbeta) activation in mammary cancer cells.	retinoid acid	79-92	retinoic acid receptor beta	Homo sapiens	109-136
32865619-0	2020	Protein Kinase C Alpha (PKCalpha) overexpression leads to a better response to retinoid acid therapy through Retinoic Acid Receptor Beta (RARbeta) activation in mammary cancer cells.	retinoid acid	79-92	retinoic acid receptor alpha	Homo sapiens	138-145
32678003-7	2020	RESULTS: qRT-PCR results showed that manipulating each one of bone morphogenetic protein (BMP), fibroblast growth factor (FGF), and retinoid acid (RA) signaling was effective for the upregulation of SANLC markers.	retinoid acid	132-145	bone morphogenetic protein 1	Homo sapiens	62-88
30621740-3	2019	The aim of this study was to investigate the potential utility of all-trans retinoid acid (ATRA), an inhibitor of the annexin A2-S100A10 signalling pathway, as a new therapeutic against serous ovarian cancer.	retinoid acid	76-89	annexin A2	Homo sapiens	118-128
32120841-1	2020	The retinoid acid-related orphan receptor alpha (RORalpha), a member of the orphan nuclear receptor superfamily, functions as an unknown ligand-dependent transcription factor.	retinoid acid	4-17	RAR related orphan receptor A	Homo sapiens	49-57
31037154-13	2019	The gap junction intercellular communication (GJIC) potentiator retinoid acid increased the quantity of mitochondria transfer from BMSCs to neurons, while GJIC inhibitor 18beta glycyrrhetinic acid decreased mitochondria transfer.	retinoid acid	64-77	RAS p21 protein activator 1	Rattus norvegicus	4-7
30621740-3	2019	The aim of this study was to investigate the potential utility of all-trans retinoid acid (ATRA), an inhibitor of the annexin A2-S100A10 signalling pathway, as a new therapeutic against serous ovarian cancer.	retinoid acid	76-89	S100 calcium binding protein A10	Homo sapiens	129-136
30415545-6	2018	p,p"-DDE induced a decrease in the expression of genes involved in the retinoid acid biosynthesis pathway (Crabp1; -2.07-fold; p = 0.018), eNOS activation (Nos1; -1.64-fold; p = 0.012), and regulation and urea cycle (Ass1; -2.07-fold; p = 0.02).	retinoid acid	71-84	cellular retinoic acid binding protein 1	Rattus norvegicus	107-113
30337838-8	2018	In addition, R-spondin2 promotes stem cell self-renewal and suppresses retinoid acid- or growth factor deprivation-induced differentiation, indicating R-spondin 2 maintains stem cell traits in GBM.	retinoid acid	71-84	R-spondin 2	Homo sapiens	13-23
28766169-0	2018	Retinoid acid and taurine promote NeuroD1-induced differentiation of induced pluripotent stem cells into retinal ganglion cells.	retinoid acid	0-13	neuronal differentiation 1	Homo sapiens	34-41
29482449-0	2018	P53 Promotes Retinoid Acid-induced Smooth Muscle Cell Differentiation by Targeting Myocardin.	retinoid acid	13-26	transformation related protein 53	Mus musculus	0-3
29482449-0	2018	P53 Promotes Retinoid Acid-induced Smooth Muscle Cell Differentiation by Targeting Myocardin.	retinoid acid	13-26	myocardin	Mus musculus	83-92
29482449-4	2018	Using retinoid acid (RA)-induced SMC differentiation models, we observed that p53 expression is increased during in vitro differentiation of mouse ESCs into SMCs.	retinoid acid	6-19	transformation related protein 53	Mus musculus	78-81
28766169-6	2018	Retinoid acid (RA) and taurine further improved the differentiation efficiency of iPSCs overexpressing NeuroD1.	retinoid acid	0-13	neuronal differentiation 1	Homo sapiens	103-110
29163067-0	2017	The BAF45D Protein Is Preferentially Expressed in Adult Neurogenic Zones and in Neurons and May Be Required for Retinoid Acid Induced PAX6 Expression.	retinoid acid	112-125	double PHD fingers 2	Homo sapiens	4-10
29163067-0	2017	The BAF45D Protein Is Preferentially Expressed in Adult Neurogenic Zones and in Neurons and May Be Required for Retinoid Acid Induced PAX6 Expression.	retinoid acid	112-125	paired box 6	Homo sapiens	134-138
27910960-9	2016	Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation.	retinoid acid	112-125	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	23-28
28677156-3	2017	Using WB, FACS, and immunofluorescence methodologies, we found dioscin significantly activated the transcription and translation of Cx43 via the retinoid acid signaling pathway and simultaneously enhanced the transporting function of Cx43.	retinoid acid	145-158	gap junction protein, alpha 1	Mus musculus	132-136
27593925-2	2017	Among other functions, SWI/SNF orchestrates the response to retinoid acid (RA) and glucocorticoids (GC) involving downregulation of MYC.	retinoid acid	60-73	myelocytomatosis oncogene	Mus musculus	132-135
27889377-0	2017	Retinoid acid-induced microRNA-27b-3p impairs C2C12 myoblast proliferation and differentiation by suppressing alpha-dystrobrevin.	retinoid acid	0-13	dystrobrevin alpha	Mus musculus	110-128
27910960-9	2016	Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation.	retinoid acid	112-125	netrin 1	Homo sapiens	37-41
27910960-9	2016	Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation.	retinoid acid	112-125	unc-5 netrin receptor B	Homo sapiens	59-64
27251573-8	2016	The effectiveness of the immunotoxin can be further increased by stimulating CD38 expression using retinoid acid.	retinoid acid	99-112	CD38 molecule	Homo sapiens	77-81
25753732-10	2015	Using Cdx1 as an entry point, we identified the retinoid acid (RA) and canonical Wnt pathways as downstream targets of Gpr161.	retinoid acid	48-61	caudal type homeobox 1	Mus musculus	6-10
27104669-7	2016	CONCLUSIONS These results indicate that the combination of these novel natural agents with retinoid acid may be clinically effective in NRAS mutant melanoma.	retinoid acid	91-104	NRAS proto-oncogene, GTPase	Homo sapiens	136-140
26080448-0	2015	Arginine methylation of HSP70 regulates retinoid acid-mediated RARbeta2 gene activation.	retinoid acid	40-53	heat shock protein family A (Hsp70) member 4	Homo sapiens	24-29
26080448-3	2015	Functional studies revealed that HSP70 could directly regulate retinoid acid (RA)-induced retinoid acid receptor beta2 (RARbeta2) gene transcription through its binding to chromatin, with R469me1 being essential in this process.	retinoid acid	63-76	heat shock protein family A (Hsp70) member 4	Homo sapiens	33-38
26080448-3	2015	Functional studies revealed that HSP70 could directly regulate retinoid acid (RA)-induced retinoid acid receptor beta2 (RARbeta2) gene transcription through its binding to chromatin, with R469me1 being essential in this process.	retinoid acid	63-76	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	113-118
25753732-10	2015	Using Cdx1 as an entry point, we identified the retinoid acid (RA) and canonical Wnt pathways as downstream targets of Gpr161.	retinoid acid	48-61	G protein-coupled receptor 161	Mus musculus	119-125
25292047-0	2014	A novel all-trans retinoid acid derivative N-(3-trifluoromethyl- phenyl)- retinamide inhibits lung adenocarcinoma A549 cell migration through down-regulating expression of myosin light chain kinase.	retinoid acid	18-31	myosin light chain kinase	Homo sapiens	172-197
25887926-0	2015	All-trans retinoid acid promotes allogeneic corneal graft survival in mice by regulating Treg-Th17 balance in the presence of TGF-beta.	retinoid acid	10-23	transforming growth factor, beta 1	Mus musculus	126-134
24691220-4	2014	Here, we show that recipient CCR7(+), but not CCR7(-), DCs in MLN induced donor T cell expression of gut-specific homing and chemokine receptors in a retinoid acid-dependent manner.	retinoid acid	150-163	C-C motif chemokine receptor 7	Homo sapiens	29-33
24513686-1	2014	BACKGROUND: As an important component of retinoid acid signaling pathway, the retinoid X receptor alpha (RXRA) is considered to play an important role in the pathogenesis of tetralogy of Fallot (TOF).	retinoid acid	41-54	retinoid X receptor alpha	Homo sapiens	78-103
24513686-1	2014	BACKGROUND: As an important component of retinoid acid signaling pathway, the retinoid X receptor alpha (RXRA) is considered to play an important role in the pathogenesis of tetralogy of Fallot (TOF).	retinoid acid	41-54	retinoid X receptor alpha	Homo sapiens	105-109
24308840-10	2014	CONCLUSIONS AND IMPLICATIONS: This blocker of retinoid acid signalling also exerted non-genomic effects through activating the pain-initiating TRPV1 and TRPA1 channels.	retinoid acid	46-59	transient receptor potential cation channel subfamily V member 1	Homo sapiens	143-148
24308840-10	2014	CONCLUSIONS AND IMPLICATIONS: This blocker of retinoid acid signalling also exerted non-genomic effects through activating the pain-initiating TRPV1 and TRPA1 channels.	retinoid acid	46-59	transient receptor potential cation channel subfamily A member 1	Homo sapiens	153-158
23602051-0	2013	A novel all-trans retinoid acid derivatives inhibits the migration of breast cancer cell lines MDA-MB-231 via myosin light chain kinase involving p38-MAPK pathway.	retinoid acid	18-31	myosin light chain kinase	Homo sapiens	110-135
25522241-13	2014	Studying retinoid acid (RA) response of SH-SY5Y cell line, a model of human metastatic neuroblastoma, we found that HOXD-AS1 is a subject to morphogenic regulation, is activated by PI3K/Akt pathway and itself is involved in control of RA-induced cell differentiation.	retinoid acid	9-22	HOXD antisense growth-associated long non-coding RNA	Homo sapiens	116-124
24824789-2	2014	Knockdown of HOTAIRM1 in the NB4 acute promyelocytic leukemia cell line retarded all-trans retinoid acid (ATRA)-induced granulocytic differentiation, resulting in a significantly larger population of immature and proliferating cells that maintained cell cycle progression from G1 to S phases.	retinoid acid	91-104	HOXA transcript antisense RNA, myeloid-specific 1	Homo sapiens	13-21
24065740-5	2013	We further demonstrated that H3.3 actively marks enhancers and determines the transcriptional potential of retinoid acid (RA)-regulated genes via creating an open chromatin signature that enables the binding of RAR/RXR.	retinoid acid	107-120	retinoid X receptor alpha	Homo sapiens	215-218
23602051-0	2013	A novel all-trans retinoid acid derivatives inhibits the migration of breast cancer cell lines MDA-MB-231 via myosin light chain kinase involving p38-MAPK pathway.	retinoid acid	18-31	mitogen-activated protein kinase 14	Homo sapiens	146-149
23175366-2	2013	Among virus-encoded proteins, the 3C protein compromises the type I interferon (IFN-I) response mediated by retinoid acid-inducible gene-I (RIG-I) or Toll-like receptor 3 that activates interferon regulatory 3 (IRF3) and IRF7.	retinoid acid	108-121	interferon regulatory factor 3	Homo sapiens	211-215
23416099-0	2013	Retinoid acid specifies neuronal identity through graded expression of Ascl1.	retinoid acid	0-13	achaete-scute family bHLH transcription factor 1	Homo sapiens	71-76
23175366-2	2013	Among virus-encoded proteins, the 3C protein compromises the type I interferon (IFN-I) response mediated by retinoid acid-inducible gene-I (RIG-I) or Toll-like receptor 3 that activates interferon regulatory 3 (IRF3) and IRF7.	retinoid acid	108-121	interferon regulatory factor 7	Homo sapiens	221-225
24564241-8	2013	It was found that Vitamin A, retinoid acid and a few other immune response agents modulated by RARA and LCK genes may be potential treatments for both schizophrenia and hepatocellular carcinoma.	retinoid acid	29-42	retinoic acid receptor alpha	Homo sapiens	95-99
24564241-8	2013	It was found that Vitamin A, retinoid acid and a few other immune response agents modulated by RARA and LCK genes may be potential treatments for both schizophrenia and hepatocellular carcinoma.	retinoid acid	29-42	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	104-107
22542624-1	2012	Additional sex comb-like 1 (ASXL1) has been suggested to be an enhancer of trithorax and polycomb proteins, and functions as a dual co-regulator of retinoid acid (RA) signaling.	retinoid acid	148-161	ASXL transcriptional regulator 1	Homo sapiens	0-26
22542624-1	2012	Additional sex comb-like 1 (ASXL1) has been suggested to be an enhancer of trithorax and polycomb proteins, and functions as a dual co-regulator of retinoid acid (RA) signaling.	retinoid acid	148-161	ASXL transcriptional regulator 1	Homo sapiens	28-33
22445976-2	2012	METHODS: Fluorescence trace was used to assay the gap junction intercellular communication mediated by Cx26/Cx32 in Hela cells and its functional modulation by the pharmacological agents (oleamide, retinoid acid).	retinoid acid	198-211	gap junction protein beta 2	Homo sapiens	103-107
22445976-2	2012	METHODS: Fluorescence trace was used to assay the gap junction intercellular communication mediated by Cx26/Cx32 in Hela cells and its functional modulation by the pharmacological agents (oleamide, retinoid acid).	retinoid acid	198-211	gap junction protein beta 1	Homo sapiens	108-112
22768254-11	2012	14-3-3sigma overexpression attenuated beta-catenin phosphorylation and rescued the decline of beta-catenin induced by retinoid acid.	retinoid acid	118-131	catenin (cadherin associated protein), beta 1	Mus musculus	94-106
22110742-0	2011	Inactivation of SAG E3 ubiquitin ligase blocks embryonic stem cell differentiation and sensitizes leukemia cells to retinoid acid.	retinoid acid	116-129	sarcoma antigen 1	Homo sapiens	16-21
21917080-8	2011	The IMP3 expression decreased by induction of differentiation with retinoid acid treatment in SK-N-DZ and SK-N-SH cells in vitro.	retinoid acid	67-80	IMP U3 small nucleolar ribonucleoprotein 3	Homo sapiens	4-8
20577838-0	2010	Targeting Smad4 links microRNA-146a to the TGF-beta pathway during retinoid acid induction in acute promyelocytic leukemia cell line.	retinoid acid	67-80	SMAD family member 4	Homo sapiens	10-15
20577838-0	2010	Targeting Smad4 links microRNA-146a to the TGF-beta pathway during retinoid acid induction in acute promyelocytic leukemia cell line.	retinoid acid	67-80	transforming growth factor beta 1	Homo sapiens	43-51
20206178-9	2010	During early stages of development, exposure of cells to noggin and retinoid acid, followed by FGF10, generated pancreatic cells (PDX1+; 50%-80%) that coexpressed FOXA2, HNF6, and SOX9.	retinoid acid	68-81	pancreatic and duodenal homeobox 1	Homo sapiens	130-134
20206178-9	2010	During early stages of development, exposure of cells to noggin and retinoid acid, followed by FGF10, generated pancreatic cells (PDX1+; 50%-80%) that coexpressed FOXA2, HNF6, and SOX9.	retinoid acid	68-81	forkhead box A2	Homo sapiens	163-168
20206178-9	2010	During early stages of development, exposure of cells to noggin and retinoid acid, followed by FGF10, generated pancreatic cells (PDX1+; 50%-80%) that coexpressed FOXA2, HNF6, and SOX9.	retinoid acid	68-81	one cut homeobox 1	Homo sapiens	170-174
20206178-9	2010	During early stages of development, exposure of cells to noggin and retinoid acid, followed by FGF10, generated pancreatic cells (PDX1+; 50%-80%) that coexpressed FOXA2, HNF6, and SOX9.	retinoid acid	68-81	SRY-box transcription factor 9	Homo sapiens	180-184
19952854-3	2010	In this study, neuroD expression was found to be significantly increased in the all-trans retinoid acid-treated P19 cells.	retinoid acid	90-103	neuronal differentiation 1	Homo sapiens	15-21
20118242-0	2010	miR-10a contributes to retinoid acid-induced smooth muscle cell differentiation.	retinoid acid	23-36	microRNA 10a	Mus musculus	0-7
19997087-5	2010	Importantly, inhibition of Wwp2 expression by specific RNA interference elevates the Oct4 protein level, leading to attenuation in retinoid acid-induced activation of differentiation-related marker genes.	retinoid acid	131-144	WW domain containing E3 ubiquitin protein ligase 2	Mus musculus	27-31
19997087-5	2010	Importantly, inhibition of Wwp2 expression by specific RNA interference elevates the Oct4 protein level, leading to attenuation in retinoid acid-induced activation of differentiation-related marker genes.	retinoid acid	131-144	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	85-89
19952854-6	2010	The data suggest that the elevation of HDAC3 and neuroD in all-trans retinoid acid-treated cells exponentially increases the neuroD expression and mediates an early commitment of P19 cells for neuronal differentiation.	retinoid acid	69-82	histone deacetylase 3	Homo sapiens	39-44
19952854-6	2010	The data suggest that the elevation of HDAC3 and neuroD in all-trans retinoid acid-treated cells exponentially increases the neuroD expression and mediates an early commitment of P19 cells for neuronal differentiation.	retinoid acid	69-82	neuronal differentiation 1	Homo sapiens	49-55
19952854-6	2010	The data suggest that the elevation of HDAC3 and neuroD in all-trans retinoid acid-treated cells exponentially increases the neuroD expression and mediates an early commitment of P19 cells for neuronal differentiation.	retinoid acid	69-82	neuronal differentiation 1	Homo sapiens	125-131
19747919-7	2009	We further show that miR-10a is a retinoid acid target and that retinoic acid receptor antagonists effectively repress miR-10a expression and completely block metastasis.	retinoid acid	34-47	microRNA 10a	Homo sapiens	21-28
20430726-7	2009	Moreover, the concentrations of soluble Ligand for APO-1/Fas antigen in the supernatants of CaSki and HeLa cell lines were significantly lower in the culture incubated with All-trans retinoid acid when compared to the control culture.	retinoid acid	183-196	Fas cell surface death receptor	Homo sapiens	51-56
19363708-0	2009	Modification of TGF-beta1 signaling pathway during NB4 cells differentiation by all-trans retinoid acid induction.	retinoid acid	90-103	transforming growth factor beta 1	Homo sapiens	16-25
20430726-7	2009	Moreover, the concentrations of soluble Ligand for APO-1/Fas antigen in the supernatants of CaSki and HeLa cell lines were significantly lower in the culture incubated with All-trans retinoid acid when compared to the control culture.	retinoid acid	183-196	Fas cell surface death receptor	Homo sapiens	57-68
19088833-10	2008	Disulfiram which inhibits the synthesis of retinoid acid may suppress deprivation myopia by up-regulating the expression level of TGF-beta2 mRNA.	retinoid acid	43-56	transforming growth factor beta 2	Gallus gallus	130-139
18821215-0	2008	Retinoid acid inhibits IL-1-induced iNOS, COX-2 and chemokine production in human chondrocytes.	retinoid acid	0-13	nitric oxide synthase 2	Homo sapiens	36-40
18821215-0	2008	Retinoid acid inhibits IL-1-induced iNOS, COX-2 and chemokine production in human chondrocytes.	retinoid acid	0-13	prostaglandin-endoperoxide synthase 2	Homo sapiens	42-47
15455391-1	2005	Tazarotene-induced gene 1 (TIG1) and Tazarotene-induced gene 3 (TIG3) are retinoid acid (RA) target genes as well as candidate tumor suppressor genes in human cancers.	retinoid acid	74-87	retinoic acid receptor responder 1	Homo sapiens	0-25
17341595-6	2007	The retinoid acid signaling pathway was also altered in lxralpha;beta-/- mice, with a higher accumulation of all-trans retinoid receptor alpha, all-trans retinoid receptor beta, and retinoic aldehyde dehydrogenase-2 mRNA.	retinoid acid	4-17	nuclear receptor subfamily 1, group H, member 3	Mus musculus	56-64
16674946-1	2006	Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of retinoid absorption maxima, by AnxA6-Trp fluorescence quenching and by a fluorescence resonance energy transfer from a Trp residue of AnxA6 to retinol.	retinoid acid	44-57	annexin A6	Homo sapiens	87-97
16674946-1	2006	Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of retinoid absorption maxima, by AnxA6-Trp fluorescence quenching and by a fluorescence resonance energy transfer from a Trp residue of AnxA6 to retinol.	retinoid acid	44-57	annexin A6	Homo sapiens	99-104
16674946-1	2006	Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of retinoid absorption maxima, by AnxA6-Trp fluorescence quenching and by a fluorescence resonance energy transfer from a Trp residue of AnxA6 to retinol.	retinoid acid	44-57	annexin A6	Homo sapiens	122-127
16674946-1	2006	Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of retinoid absorption maxima, by AnxA6-Trp fluorescence quenching and by a fluorescence resonance energy transfer from a Trp residue of AnxA6 to retinol.	retinoid acid	44-57	annexin A6	Homo sapiens	122-127
16674946-1	2006	Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of retinoid absorption maxima, by AnxA6-Trp fluorescence quenching and by a fluorescence resonance energy transfer from a Trp residue of AnxA6 to retinol.	retinoid acid	44-57	annexin A6	Homo sapiens	122-127
17088287-5	2006	Repression activity assays, chromatin immunoprecipitation (ChIP) and DNA pulldown assays all verified that NSPc1 represses the expression of p21Waf1/Cip1 by binding to the (-1357 to -1083) region of the p21Waf1/Cip1 promoter in vivo, and the repression effect is dependent on the retinoid acid response element (RARE element) within the above region of the p21Waf1/Cip1 promoter.	retinoid acid	280-293	polycomb group ring finger 1	Homo sapiens	107-112
16051514-2	2005	The exposed RNA template of hTR is an ideal target for antisense oligonucleotides (As-ODN); while recent findings indicate all-trans retinoid acid (ATRA) could effectively inhibit the expression of catalytic subunit-hTERT.	retinoid acid	133-146	telomerase RNA component	Homo sapiens	28-31
16051514-2	2005	The exposed RNA template of hTR is an ideal target for antisense oligonucleotides (As-ODN); while recent findings indicate all-trans retinoid acid (ATRA) could effectively inhibit the expression of catalytic subunit-hTERT.	retinoid acid	133-146	telomerase reverse transcriptase	Homo sapiens	216-221
15455391-1	2005	Tazarotene-induced gene 1 (TIG1) and Tazarotene-induced gene 3 (TIG3) are retinoid acid (RA) target genes as well as candidate tumor suppressor genes in human cancers.	retinoid acid	74-87	retinoic acid receptor responder 1	Homo sapiens	27-31
15455391-1	2005	Tazarotene-induced gene 1 (TIG1) and Tazarotene-induced gene 3 (TIG3) are retinoid acid (RA) target genes as well as candidate tumor suppressor genes in human cancers.	retinoid acid	74-87	phospholipase A and acyltransferase 4	Homo sapiens	37-62
15455391-1	2005	Tazarotene-induced gene 1 (TIG1) and Tazarotene-induced gene 3 (TIG3) are retinoid acid (RA) target genes as well as candidate tumor suppressor genes in human cancers.	retinoid acid	74-87	phospholipase A and acyltransferase 4	Homo sapiens	64-68
15058751-0	2003	All-trans retinoid acid increases Notch1 transcript expression in acute promyelocytic leukemia.	retinoid acid	10-23	notch receptor 1	Homo sapiens	34-40
15157320-0	2004	[The effect of all-trans retinoid acid and sodium selenite (Na2SeO3) on VEGF and its receptor expression in HL-60 cells].	retinoid acid	25-38	vascular endothelial growth factor A	Homo sapiens	72-76
15157320-1	2004	In order to investigate the effect of non-medullar toxicity drug - all trans retinoid acid (ATRA) and cancer preventive trace element-selenium compound - sodium selenite (Na(2)SeO(3)) on the expression of vascular endothelial growth factor (VEGF) and its receptor in HL-60 cells, the expression of VEGF and its receptor in HL-60 cells were detected by ELISA technique and flow cytometry before and after treatment with two drugs.	retinoid acid	77-90	vascular endothelial growth factor A	Homo sapiens	205-239
15058751-1	2003	The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied.	retinoid acid	24-37	notch receptor 1	Homo sapiens	66-72
12795836-0	2003	[Phosphorylated JNK mediated apoptosis induced by all trans retinoid acid in human retinoblastoma cell line].	retinoid acid	60-73	mitogen-activated protein kinase 8	Homo sapiens	16-19
11069026-0	2000	Defect in the regulation of 4E-BP1 and 2, two repressors of translation initiation, in the retinoid acid resistant cell lines, NB4-R1 and NB4-R2.	retinoid acid	91-104	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	28-40
12438255-11	2002	In addition, retinol-related genes such as CRABP2 and retinol-binding protein 1 were overexpressed in WT, and CRABP2 was more highly expressed in the poor outcome patients, which suggests that retinoid acid may be a potential drug.	retinoid acid	193-206	cellular retinoic acid binding protein 2	Homo sapiens	43-49
12438255-11	2002	In addition, retinol-related genes such as CRABP2 and retinol-binding protein 1 were overexpressed in WT, and CRABP2 was more highly expressed in the poor outcome patients, which suggests that retinoid acid may be a potential drug.	retinoid acid	193-206	retinol binding protein 1	Homo sapiens	54-79
12438255-11	2002	In addition, retinol-related genes such as CRABP2 and retinol-binding protein 1 were overexpressed in WT, and CRABP2 was more highly expressed in the poor outcome patients, which suggests that retinoid acid may be a potential drug.	retinoid acid	193-206	cellular retinoic acid binding protein 2	Homo sapiens	110-116
12412372-3	2002	This work also led to the identification of the first gene (RAR beta) encoding a receptor for the active derivative of vitamin A, retinoid acid.	retinoid acid	130-143	retinoic acid receptor beta	Homo sapiens	60-68
11434680-0	2001	Signal transduction pathways underlying the expression of tissue factor and thrombomodulin in promyelocytic cells induced to differentiate by retinoid acid and dibutyryl cAMP.	retinoid acid	142-155	coagulation factor III, tissue factor	Homo sapiens	58-71
11434680-0	2001	Signal transduction pathways underlying the expression of tissue factor and thrombomodulin in promyelocytic cells induced to differentiate by retinoid acid and dibutyryl cAMP.	retinoid acid	142-155	thrombomodulin	Homo sapiens	76-90
11434680-2	2001	During retinoid acid (RA)- and dibutyryl cAMP (dbcAMP)-induced differentiation of the APL cells, there is a marked up-modulation of both the protein kinase A (PKA) and C (PKC) activities.	retinoid acid	7-20	proline rich transmembrane protein 2	Homo sapiens	171-174
11812347-0	2001	[Alteration of Fas/FasL gene expression in oral squamous cell carcinoma cell line Tca83 by retinoid acid].	retinoid acid	91-104	Fas ligand	Homo sapiens	19-23
10383375-3	1999	Here we demonstrate that retinoid acid- mediated growth inhibition is accompanied with reduced expression of c-erbB-4/HER4 in T47D breast cancer cells as determined by FACS, Western, and RT-PCR.	retinoid acid	25-38	erb-b2 receptor tyrosine kinase 4	Homo sapiens	118-122
10077563-3	1999	Studies by several groups demonstrate that this complex is recruited to nuclear receptors through the highly related corepressors SMRT (silencing mediator of retinoid acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor).	retinoid acid	158-171	nuclear receptor corepressor 2	Homo sapiens	130-134
10077563-3	1999	Studies by several groups demonstrate that this complex is recruited to nuclear receptors through the highly related corepressors SMRT (silencing mediator of retinoid acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor).	retinoid acid	158-171	nuclear receptor co-repressor 1	Mus musculus	206-211
7980510-1	1994	Because of the growing importance of the Retinoid X Receptors (RXR alpha, beta and gamma) in the retinoid acid signalling pathway, we have prepared polyclonal and monoclonal antibodies directed against these proteins.	retinoid acid	97-110	retinoid X receptor alpha	Mus musculus	63-72
9538388-2	1997	Several therapeutic trials with retinoids and r interferon alpha (r IFN alpha) suggest a synergic antiproliferative effect between retinoid acid and r IFN alpha.	retinoid acid	131-144	interferon alpha 1	Homo sapiens	68-77
8216267-0	1993	RXR-independent action of the receptors for thyroid hormone, retinoid acid and vitamin D on inverted palindromes.	retinoid acid	61-74	retinoid X receptor alpha	Homo sapiens	0-3