PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25411367-4	2015	We generated a new CB1 inverse agonist, (4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229), from the class of benzhydryl piperazine analogs.	norcyclizine	150-171	cannabinoid receptor 1	Homo sapiens	19-22
8088342-1	1994	Several diphenylmethylpiperazine derivatives are potential therapeutic agents for prevention of ischemic injuries in the heart and brain, because of their ability to block Ca2+ currents and their antioxidant activity.	norcyclizine	8-32	carbonic anhydrase 2	Mus musculus	172-175
29987956-3	2018	The built structure-activity relationship showed that the incorporation of benzhydryl piperazine tails on a phenyl sulfamide scaffold determines rather good efficacies against hCA I and VchCAalpha, with several compounds showing KIs < 100 nM.	norcyclizine	75-96	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	176-196
29421700-2	2018	In the present study, two series of 4-substituted phenylpiperazine and 1-benzhydrylpiperazine (1-21) derivatives were synthesized and screened for their MAO-A and MAO-B inhibitory activity using Amplex Red assay.	norcyclizine	71-93	monoamine oxidase A	Homo sapiens	153-158
29421700-2	2018	In the present study, two series of 4-substituted phenylpiperazine and 1-benzhydrylpiperazine (1-21) derivatives were synthesized and screened for their MAO-A and MAO-B inhibitory activity using Amplex Red assay.	norcyclizine	71-93	monoamine oxidase B	Homo sapiens	163-168
11140170-1	2000	In experiments on Wistar and Long Evans rats, using behavioral methods for passive (step-down and step-through) and active (shuttle-box two-way avoidance with punishment reinforcement) the newly synthesized diphenyl-methyl-piperazine derivative with Ca2+ and 5-HT antagonistic action dotarizine (DOT) administered repeatedly at oral doses of 50 and 10 mg/kg in some cases improve memory process.	norcyclizine	207-233	carbonic anhydrase 2	Rattus norvegicus	250-253
22209223-13	2012	Cyclizine metabolism to norcyclizine may include CYP2D6 as the metabolic ratio varied with CYP2D6 genotype in the SC group.	norcyclizine	24-36	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	49-55
22209223-13	2012	Cyclizine metabolism to norcyclizine may include CYP2D6 as the metabolic ratio varied with CYP2D6 genotype in the SC group.	norcyclizine	24-36	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	91-97
18243711-2	2008	Several series of urea, carbamate, amide, sulfonamide and oxalamide derivatives based on 1-benzhydrylpiperazine scaffold were synthesized and tested for CB1 receptor binding affinity.	norcyclizine	89-111	cannabinoid receptor 1	Homo sapiens	153-156
21937154-1	2011	We recently discovered and reported a novel series of benzhydrylpiperazine derivatives bearing an asymmetric carbon atom that are potent and selective hCB1 inverse agonists.	norcyclizine	54-74	cannabinoid receptor 1	Homo sapiens	151-155
20047779-0	2010	Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach.	norcyclizine	13-33	cannabinoid receptor 1	Rattus norvegicus	49-52