PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3168151-6	1988	Of these, only BCNU and CCNU, the chloroethylnitrosoureas having all three of the macromolecule-modifying activities, strongly induce HSP70 RNA levels in a dose-dependent and time-dependent manner.	1-(2-chloroethyl)-1-nitrosourea	34-57	heat shock protein family A (Hsp70) member 4	Homo sapiens	134-139
3390222-3	1988	In the ligand exchange assay, cytosolic receptors preloaded with 17 alpha-CNU and HEX-CNU were found to lose some of their estradiol (E2) binding sites, suggesting that binding to estrogen receptor (ER) may be irreversible.	1-(2-chloroethyl)-1-nitrosourea	73-77	estrogen receptor 1	Rattus norvegicus	180-197
3405749-1	1988	Repair of chloroethylnitrosourea (CENU)-induced precursors of DNA interstrand cross-links by O6-alkylguanine-DNA alkyltransferase (GAT or GATase) appears to be a factor in tumor resistance to therapy with this class of antineoplastic drugs.	1-(2-chloroethyl)-1-nitrosourea	10-32	glycine-N-acyltransferase	Homo sapiens	131-134
3405749-1	1988	Repair of chloroethylnitrosourea (CENU)-induced precursors of DNA interstrand cross-links by O6-alkylguanine-DNA alkyltransferase (GAT or GATase) appears to be a factor in tumor resistance to therapy with this class of antineoplastic drugs.	1-(2-chloroethyl)-1-nitrosourea	34-38	glycine-N-acyltransferase	Homo sapiens	131-134
3390222-3	1988	In the ligand exchange assay, cytosolic receptors preloaded with 17 alpha-CNU and HEX-CNU were found to lose some of their estradiol (E2) binding sites, suggesting that binding to estrogen receptor (ER) may be irreversible.	1-(2-chloroethyl)-1-nitrosourea	73-77	estrogen receptor 1	Rattus norvegicus	199-201
3290854-2	1988	Both hydroxyethyl and chloroethyl phosphotriesters of dTpdT were identified; a similar reaction between CNU and dTR yielded 3-hydroxyethyl and 3-chloroethyl dTR as the major products of ring alkylation.	1-(2-chloroethyl)-1-nitrosourea	104-107	defective transmitter release	Drosophila melanogaster	112-115
3290854-2	1988	Both hydroxyethyl and chloroethyl phosphotriesters of dTpdT were identified; a similar reaction between CNU and dTR yielded 3-hydroxyethyl and 3-chloroethyl dTR as the major products of ring alkylation.	1-(2-chloroethyl)-1-nitrosourea	104-107	defective transmitter release	Drosophila melanogaster	157-160
3742731-0	1986	Transfection of DNA from a chloroethylnitrosourea-resistant tumor cell line (MER+) to a sensitive tumor cell line (MER-) results in a tumor cell line resistant to MNNG and CNU that has increased O-6-methylguanine-DNA methyltransferase levels and reduced levels of DNA interstrand crosslinking.	1-(2-chloroethyl)-1-nitrosourea	27-49	O-6-methylguanine-DNA methyltransferase	Homo sapiens	195-234
6359062-0	1983	Cross-linking of DNA induced by chloroethylnitrosourea is presented by O6-methylguanine-DNA methyltransferase.	1-(2-chloroethyl)-1-nitrosourea	32-54	O-6-methylguanine-DNA methyltransferase	Homo sapiens	71-109
6585269-5	1984	These observations indicate that the number of cross-links induced by the chloroethylnitrosoureas and, hence, their cytotoxicity, should be inversely related to O6-methylguanine-DNA methyltransferase content of a cell.	1-(2-chloroethyl)-1-nitrosourea	74-97	O-6-methylguanine-DNA methyltransferase	Homo sapiens	161-199
6099910-7	1984	This is supported by the observation that inhibition of liver superoxide dismutase and glutathione reductase, by treatment of rats with diethyldithiocarbamate and chloroethyl nitrosourea, respectively, renders the microsomal membranes more resistant to lipid peroxidation in vitro.	1-(2-chloroethyl)-1-nitrosourea	163-186	glutathione-disulfide reductase	Rattus norvegicus	87-108
3948156-0	1986	Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base.	1-(2-chloroethyl)-1-nitrosourea	108-130	O-6-methylguanine-DNA methyltransferase	Homo sapiens	16-54
3948156-1	1986	Human fibroblasts and tumor cells with constitutive levels of the DNA repair protein O6-methylguanine-DNA methyltransferase were incubated with mM concentrations of the free base O6-methylguanine for up to 24 h. This treatment depleted the cells of their transferase activity, and sensitized the cells to killing by the antineoplastic drug 1-[2-chloroethyl]-1-nitrosourea.	1-(2-chloroethyl)-1-nitrosourea	340-371	O-6-methylguanine-DNA methyltransferase	Homo sapiens	85-123
3857628-7	1985	These results suggest that O6-methylguanine-DNA methyltransferase levels in human tumor cells may be a clinically useful predictor of sensitivity to the chloroethylnitrosoureas.	1-(2-chloroethyl)-1-nitrosourea	153-176	O-6-methylguanine-DNA methyltransferase	Homo sapiens	27-65
6359062-1	1983	The DNA repair enzyme O6-methylguanine-DNA methyltransferase has been used as a reagent to analyse the initial reaction sites of alkylating agents such as chloroethylnitrosourea that cross-link DNA.	1-(2-chloroethyl)-1-nitrosourea	155-177	O-6-methylguanine-DNA methyltransferase	Homo sapiens	22-60
6407751-1	1983	alpha-Difluoromethylornithine, an enzyme-activated, irreversible inhibitor of ornithine decarboxylase, inhibited the growth of both chloroethylnitrosourea-sensitive and -resistant 9L rat brain tumor cells in vitro.	1-(2-chloroethyl)-1-nitrosourea	132-154	ornithine decarboxylase 1	Rattus norvegicus	78-101
29961141-8	2019	These results show for the first time that CN-1 can be detected in urine and warrants prospective studies to assess the relevance of CNU for renal function deterioration in diabetes patients.	1-(2-chloroethyl)-1-nitrosourea	133-136	carnosine dipeptidase 1	Homo sapiens	43-47
32628955-4	2020	We find that Hha is less stable and folds an order of magnitude slower than Cnu despite similar packing and topological features.	1-(2-chloroethyl)-1-nitrosourea	76-79	anosmin 1	Homo sapiens	13-16
18000822-2	2008	Here, we determined MGMT activity in primary and recurrent glioblastomas (GBM, WHO grade IV) of patients who received radiation therapy (RT) or RT plus chemotherapy with alkylating agents (temozolomide, chloroethylnitrosoureas).	1-(2-chloroethyl)-1-nitrosourea	203-226	O-6-methylguanine-DNA methyltransferase	Homo sapiens	20-24
18097542-0	2008	PP2A activity is controlled by methylation and regulates oncoprotein expression in melanoma cells: a mechanism which participates in growth inhibition induced by chloroethylnitrosourea treatment.	1-(2-chloroethyl)-1-nitrosourea	162-184	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	0-4
18097542-8	2008	During the response to CENU treatment, PP2A methylation and activity were strongly increased, Akt activation and c-Myc expression were decreased.	1-(2-chloroethyl)-1-nitrosourea	23-27	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	39-43
18097542-8	2008	During the response to CENU treatment, PP2A methylation and activity were strongly increased, Akt activation and c-Myc expression were decreased.	1-(2-chloroethyl)-1-nitrosourea	23-27	thymoma viral proto-oncogene 1	Mus musculus	94-97
18089819-9	2007	Therefore, functional p53 seems to stimulate the repair of CNU-induced cross-links and/or DSBs generated from CNU-induced lesions.	1-(2-chloroethyl)-1-nitrosourea	59-62	tumor protein p53	Homo sapiens	22-25
18089819-9	2007	Therefore, functional p53 seems to stimulate the repair of CNU-induced cross-links and/or DSBs generated from CNU-induced lesions.	1-(2-chloroethyl)-1-nitrosourea	110-113	tumor protein p53	Homo sapiens	22-25
9927209-2	1999	The MGMT gene is highly regulated in mammalian cells and its overexpression, observed in many types of tumor cells, is often associated with cellular resistance to CNU.	1-(2-chloroethyl)-1-nitrosourea	164-167	O-6-methylguanine-DNA methyltransferase	Homo sapiens	4-8
15110396-2	2004	Previously we noted that C6 glioma cells overexpressing NOS2 displayed chemoresistance against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and other chloroethylnitrosourea derivatives with carbamoylating action.	1-(2-chloroethyl)-1-nitrosourea	149-171	nitric oxide synthase 2	Homo sapiens	56-60
12517414-1	2003	The purpose of this study has been to measure the formation and repair of individual DNA alkylation products in 9L, 9L-2 and BTRC-19 cell lines after treatment with 1-(2-chloroethyl)-1-nitrosourea (CNU).	1-(2-chloroethyl)-1-nitrosourea	165-196	beta-transducin repeat containing E3 ubiquitin protein ligase	Rattus norvegicus	125-129
12174880-0	2002	Adenoviral transfer of antisenses or ribozyme to O6-methylguanine-DNA methyltransferase mRNA in brain-tumor model resistant to chloroethyl-nitrosourea.	1-(2-chloroethyl)-1-nitrosourea	127-150	O-6-methylguanine-DNA methyltransferase	Homo sapiens	49-87
10933201-0	2000	Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase.	1-(2-chloroethyl)-1-nitrosourea	72-94	O-6-methylguanine-DNA methyltransferase	Homo sapiens	124-162
10752660-1	2000	O6-methylguanine-DNA methyltransferase (MGMT), one of the DNA repair enzymes, potently repairs DNA damage induced by chloroethylnitrosoureas (CENUs).	1-(2-chloroethyl)-1-nitrosourea	117-140	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	0-38
10752660-1	2000	O6-methylguanine-DNA methyltransferase (MGMT), one of the DNA repair enzymes, potently repairs DNA damage induced by chloroethylnitrosoureas (CENUs).	1-(2-chloroethyl)-1-nitrosourea	117-140	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	40-44
10565851-1	1999	We previously demonstrated that sustained depletion of methylguanine DNA methyltransferase (MGMT) activity is required for optimal reversal of chloroethylnitrosourea resistance in tumor cells.	1-(2-chloroethyl)-1-nitrosourea	143-165	O-6-methylguanine-DNA methyltransferase	Homo sapiens	55-90
10565851-1	1999	We previously demonstrated that sustained depletion of methylguanine DNA methyltransferase (MGMT) activity is required for optimal reversal of chloroethylnitrosourea resistance in tumor cells.	1-(2-chloroethyl)-1-nitrosourea	143-165	O-6-methylguanine-DNA methyltransferase	Homo sapiens	92-96
10454526-0	1999	Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment.	1-(2-chloroethyl)-1-nitrosourea	191-213	O-6-methylguanine-DNA methyltransferase	Homo sapiens	81-119
10454526-1	1999	O(6)-Benzylguanine (6-BG) inactivates mammalian O(6)-methylguanine DNA methyltransferase (MGMT), an important DNA repair protein that protects cells against chloroethylnitrosourea (CENU) cytotoxicity.	1-(2-chloroethyl)-1-nitrosourea	157-179	O-6-methylguanine-DNA methyltransferase	Homo sapiens	48-88
10454526-1	1999	O(6)-Benzylguanine (6-BG) inactivates mammalian O(6)-methylguanine DNA methyltransferase (MGMT), an important DNA repair protein that protects cells against chloroethylnitrosourea (CENU) cytotoxicity.	1-(2-chloroethyl)-1-nitrosourea	157-179	O-6-methylguanine-DNA methyltransferase	Homo sapiens	90-94
10454526-1	1999	O(6)-Benzylguanine (6-BG) inactivates mammalian O(6)-methylguanine DNA methyltransferase (MGMT), an important DNA repair protein that protects cells against chloroethylnitrosourea (CENU) cytotoxicity.	1-(2-chloroethyl)-1-nitrosourea	181-185	O-6-methylguanine-DNA methyltransferase	Homo sapiens	48-88
10454526-1	1999	O(6)-Benzylguanine (6-BG) inactivates mammalian O(6)-methylguanine DNA methyltransferase (MGMT), an important DNA repair protein that protects cells against chloroethylnitrosourea (CENU) cytotoxicity.	1-(2-chloroethyl)-1-nitrosourea	181-185	O-6-methylguanine-DNA methyltransferase	Homo sapiens	90-94
10454526-2	1999	6-BG is being tested as an approach to treat CENU-resistant tumors that overexpress endogenous MGMT.	1-(2-chloroethyl)-1-nitrosourea	45-49	O-6-methylguanine-DNA methyltransferase	Homo sapiens	95-99
10454526-4	1999	Several 6-BG-resistant human MGMT mutants have been characterized in Escherichia coli and are predicted to protect mammalian cells against the combination of 6-BG and CENU treatment in vivo.	1-(2-chloroethyl)-1-nitrosourea	167-171	O-6-methylguanine-DNA methyltransferase	Homo sapiens	29-33
10404096-1	1999	Repair of cytotoxic DNA damage by O(6)-methylguanine-DNA methyltransferase (MGMT) is a potentially important factor of chemoresistance to chloroethylnitrosoureas (CENUs), commonly used in the treatment of glioblastoma multiforme (GBM).	1-(2-chloroethyl)-1-nitrosourea	138-161	O-6-methylguanine-DNA methyltransferase	Homo sapiens	34-74
17695447-2	2007	This potentiating effect may be due to tumor cell sensitization to chloroethylnitrosoureas through their MET dependency and the down-regulation of O6- methylguanine-DNA methyltransferase (MGMT).	1-(2-chloroethyl)-1-nitrosourea	67-90	O-6-methylguanine-DNA methyltransferase	Homo sapiens	147-186
17695447-2	2007	This potentiating effect may be due to tumor cell sensitization to chloroethylnitrosoureas through their MET dependency and the down-regulation of O6- methylguanine-DNA methyltransferase (MGMT).	1-(2-chloroethyl)-1-nitrosourea	67-90	O-6-methylguanine-DNA methyltransferase	Homo sapiens	188-192
15746058-8	2005	CONCLUSIONS: The present study identified hMLH1 methylation status as a predictor of the clinical response of malignant astrocytomas to chloroethylnitrosourea-based adjuvant therapy.	1-(2-chloroethyl)-1-nitrosourea	136-158	mutL homolog 1	Homo sapiens	42-47
14744281-1	2004	OBJECTIVE: O(6)-Methylguanine-deoxyribonucleic acid methyltransferase (MGMT) is a deoxyribonucleic acid repair protein associated with the chemoresistance of chloroethylnitrosoureas.	1-(2-chloroethyl)-1-nitrosourea	158-181	O-6-methylguanine-DNA methyltransferase	Homo sapiens	11-69
14744281-1	2004	OBJECTIVE: O(6)-Methylguanine-deoxyribonucleic acid methyltransferase (MGMT) is a deoxyribonucleic acid repair protein associated with the chemoresistance of chloroethylnitrosoureas.	1-(2-chloroethyl)-1-nitrosourea	158-181	O-6-methylguanine-DNA methyltransferase	Homo sapiens	71-75
12076959-11	2002	Further studies indicated that iNOS only neutralized carbamoylating action of chloroethylnitrosoureas.	1-(2-chloroethyl)-1-nitrosourea	78-101	nitric oxide synthase 2	Rattus norvegicus	31-35
11259558-5	2001	Further studies using compounds that each carry these different activities indicate that iNOS neutralized carbamoylating, but not alkylating, action of chloroethylnitrosoureas.	1-(2-chloroethyl)-1-nitrosourea	152-175	nitric oxide synthase 2	Rattus norvegicus	89-93
11259558-8	2001	Results from the present study demonstrate the ability of iNOS-derived NO to confer chemoresistance against the carbamoylating potential of chloroethylnitrosoureas in vitro.	1-(2-chloroethyl)-1-nitrosourea	140-163	nitric oxide synthase 2	Rattus norvegicus	58-62
11259558-9	2001	Further investigation is needed to test whether iNOS expression, frequently noted in malignant brain tumors, also enhances chemoresistance against chloroethylnitrosoureas in vivo.	1-(2-chloroethyl)-1-nitrosourea	147-170	nitric oxide synthase 2	Rattus norvegicus	48-52
10454526-10	1999	These results demonstrate the utility of screening 6-BG-resistant MGMT proteins in hematopoietic cells and provide evidence that the P140A mutant form of MGMT generates 6-BG- and CENU-resistant hematopoietic cells.	1-(2-chloroethyl)-1-nitrosourea	179-183	O-6-methylguanine-DNA methyltransferase	Homo sapiens	66-70
10454526-10	1999	These results demonstrate the utility of screening 6-BG-resistant MGMT proteins in hematopoietic cells and provide evidence that the P140A mutant form of MGMT generates 6-BG- and CENU-resistant hematopoietic cells.	1-(2-chloroethyl)-1-nitrosourea	179-183	O-6-methylguanine-DNA methyltransferase	Homo sapiens	154-158
10404096-1	1999	Repair of cytotoxic DNA damage by O(6)-methylguanine-DNA methyltransferase (MGMT) is a potentially important factor of chemoresistance to chloroethylnitrosoureas (CENUs), commonly used in the treatment of glioblastoma multiforme (GBM).	1-(2-chloroethyl)-1-nitrosourea	138-161	O-6-methylguanine-DNA methyltransferase	Homo sapiens	76-80
10352868-0	1999	Relationship between O6-methylguanine-DNA methyltransferase levels and clinical response induced by chloroethylnitrosourea therapy in glioma patients.	1-(2-chloroethyl)-1-nitrosourea	100-122	O-6-methylguanine-DNA methyltransferase	Homo sapiens	21-59
10352868-2	1999	It has been documented in cell lines that O6-methylguanine DNA methyltransferase (MGMT) plays an important role in chloroethylnitrosourea (CENU) drug resistance.	1-(2-chloroethyl)-1-nitrosourea	115-137	O-6-methylguanine-DNA methyltransferase	Homo sapiens	42-80
10352868-2	1999	It has been documented in cell lines that O6-methylguanine DNA methyltransferase (MGMT) plays an important role in chloroethylnitrosourea (CENU) drug resistance.	1-(2-chloroethyl)-1-nitrosourea	115-137	O-6-methylguanine-DNA methyltransferase	Homo sapiens	82-86
10352868-2	1999	It has been documented in cell lines that O6-methylguanine DNA methyltransferase (MGMT) plays an important role in chloroethylnitrosourea (CENU) drug resistance.	1-(2-chloroethyl)-1-nitrosourea	139-143	O-6-methylguanine-DNA methyltransferase	Homo sapiens	42-80
10352868-2	1999	It has been documented in cell lines that O6-methylguanine DNA methyltransferase (MGMT) plays an important role in chloroethylnitrosourea (CENU) drug resistance.	1-(2-chloroethyl)-1-nitrosourea	139-143	O-6-methylguanine-DNA methyltransferase	Homo sapiens	82-86
10352868-3	1999	METHODS: We evaluated MGMT expression in 22 glioma specimens by using an immunofluorescence assay and compared the results with clinical responses of the patients to CENU-based chemotherapy.	1-(2-chloroethyl)-1-nitrosourea	166-170	O-6-methylguanine-DNA methyltransferase	Homo sapiens	22-26
10352868-6	1999	The Mer- patients (MGMT < 60,000 molecules/nucleus) appeared to have more chance of stable disease or response to CENU therapy than the Mer+ patients (MGMT > 60,000 molecules/nucleus) (X2 = 4.791, p = 0.0286).	1-(2-chloroethyl)-1-nitrosourea	117-121	O-6-methylguanine-DNA methyltransferase	Homo sapiens	19-23
10352868-10	1999	CONCLUSION: This study suggests that being MGMT positive is indicative of a more aggressive disease that progresses more rapidly with CENU therapy.	1-(2-chloroethyl)-1-nitrosourea	134-138	O-6-methylguanine-DNA methyltransferase	Homo sapiens	43-47
9927209-1	1999	O6-methylguanine-DNA methyltransferase (MGMT), a ubiquitous DNA repair protein, removes the mutagenic DNA adduct O6-alkylguanine, which is synthesized both endogenously and after exposure to alkylnitrosamines and alkylating antitumor drugs such as 2-chloroethyl-N-nitrosourea (CNU).	1-(2-chloroethyl)-1-nitrosourea	248-275	O-6-methylguanine-DNA methyltransferase	Homo sapiens	0-38
9927209-1	1999	O6-methylguanine-DNA methyltransferase (MGMT), a ubiquitous DNA repair protein, removes the mutagenic DNA adduct O6-alkylguanine, which is synthesized both endogenously and after exposure to alkylnitrosamines and alkylating antitumor drugs such as 2-chloroethyl-N-nitrosourea (CNU).	1-(2-chloroethyl)-1-nitrosourea	248-275	O-6-methylguanine-DNA methyltransferase	Homo sapiens	40-44
9927209-1	1999	O6-methylguanine-DNA methyltransferase (MGMT), a ubiquitous DNA repair protein, removes the mutagenic DNA adduct O6-alkylguanine, which is synthesized both endogenously and after exposure to alkylnitrosamines and alkylating antitumor drugs such as 2-chloroethyl-N-nitrosourea (CNU).	1-(2-chloroethyl)-1-nitrosourea	277-280	O-6-methylguanine-DNA methyltransferase	Homo sapiens	0-38
9927209-1	1999	O6-methylguanine-DNA methyltransferase (MGMT), a ubiquitous DNA repair protein, removes the mutagenic DNA adduct O6-alkylguanine, which is synthesized both endogenously and after exposure to alkylnitrosamines and alkylating antitumor drugs such as 2-chloroethyl-N-nitrosourea (CNU).	1-(2-chloroethyl)-1-nitrosourea	277-280	O-6-methylguanine-DNA methyltransferase	Homo sapiens	40-44
9731508-9	1998	That TPA-mediated induction of MGMT caused increased cellular resistance to 2-chloroethyl-N-nitrosourea suggests a therapeutic significance for PKC-mediated MGMT modulation.	1-(2-chloroethyl)-1-nitrosourea	76-103	O-6-methylguanine-DNA methyltransferase	Homo sapiens	31-35
9731508-9	1998	That TPA-mediated induction of MGMT caused increased cellular resistance to 2-chloroethyl-N-nitrosourea suggests a therapeutic significance for PKC-mediated MGMT modulation.	1-(2-chloroethyl)-1-nitrosourea	76-103	O-6-methylguanine-DNA methyltransferase	Homo sapiens	157-161
21528331-0	1997	Coordinate up-regulation of cyclin-dependent kinase 4 and its inhibitor p16(INK4) in human glioma cells following chloroethylnitrosourea-induced DNA damage.	1-(2-chloroethyl)-1-nitrosourea	114-136	cyclin dependent kinase 4	Homo sapiens	28-53
17154443-2	1998	It has been documented in cell lines that O(6)-methylguanine-DNA methyltransferase (MGMT) plays an important role in chloroethylnitrosourea (CENU) drug resistance.	1-(2-chloroethyl)-1-nitrosourea	117-139	O-6-methylguanine-DNA methyltransferase	Homo sapiens	42-82
17154443-2	1998	It has been documented in cell lines that O(6)-methylguanine-DNA methyltransferase (MGMT) plays an important role in chloroethylnitrosourea (CENU) drug resistance.	1-(2-chloroethyl)-1-nitrosourea	117-139	O-6-methylguanine-DNA methyltransferase	Homo sapiens	84-88
17154443-2	1998	It has been documented in cell lines that O(6)-methylguanine-DNA methyltransferase (MGMT) plays an important role in chloroethylnitrosourea (CENU) drug resistance.	1-(2-chloroethyl)-1-nitrosourea	141-145	O-6-methylguanine-DNA methyltransferase	Homo sapiens	42-82
17154443-2	1998	It has been documented in cell lines that O(6)-methylguanine-DNA methyltransferase (MGMT) plays an important role in chloroethylnitrosourea (CENU) drug resistance.	1-(2-chloroethyl)-1-nitrosourea	141-145	O-6-methylguanine-DNA methyltransferase	Homo sapiens	84-88
17154443-3	1998	The authors evaluated MGMT expression in 22 glioma specimens by using an immunofluorescence assay and compared the results with clinical response of the patients to CENU-based chemotherapy.	1-(2-chloroethyl)-1-nitrosourea	165-169	O-6-methylguanine-DNA methyltransferase	Homo sapiens	22-26
17154443-8	1998	The Mer(-) patients (MGMT < 60,000 molecules/nucleus) appeared to have more chance of stable disease or response to CENU therapy than the Mer(+) patients (MGMT > 60,000 molecules/nucleus) (chi-square = 4.791, p = 0.0286).	1-(2-chloroethyl)-1-nitrosourea	119-123	O-6-methylguanine-DNA methyltransferase	Homo sapiens	21-25
17154443-13	1998	Results from this study suggested that MGMT positivity is indicative of more aggressive disease that progresses more rapidly when exposed to CENU therapy.	1-(2-chloroethyl)-1-nitrosourea	141-145	O-6-methylguanine-DNA methyltransferase	Homo sapiens	39-43
21528331-0	1997	Coordinate up-regulation of cyclin-dependent kinase 4 and its inhibitor p16(INK4) in human glioma cells following chloroethylnitrosourea-induced DNA damage.	1-(2-chloroethyl)-1-nitrosourea	114-136	cyclin dependent kinase inhibitor 2A	Homo sapiens	72-75
21528331-0	1997	Coordinate up-regulation of cyclin-dependent kinase 4 and its inhibitor p16(INK4) in human glioma cells following chloroethylnitrosourea-induced DNA damage.	1-(2-chloroethyl)-1-nitrosourea	114-136	cyclin dependent kinase inhibitor 2A	Homo sapiens	76-80
9354444-9	1997	These results provide evidence that MGMT expression influences both intrinsic and acquired colon tumor CENU resistance, that selective expansion of AGT+ colon tumor cells commonly occurs after CENU exposure, and that BG is effective in sensitizing colon tumors to CENUs, even when only a small fraction of the cells in a heterogeneous tumor express MGMT.	1-(2-chloroethyl)-1-nitrosourea	103-107	O-6-methylguanine-DNA methyltransferase	Homo sapiens	36-40
9148943-1	1997	The cytotoxic action of such alkylating chemotherapeutic drugs as 2-chloroethyl-N-nitrosourea (CNU) derivatives is countered by the repair protein O6-methylguanine-DNA methyltransferase (MGMT), which removes O6-alkylguanine induced in the DNA by these agents.	1-(2-chloroethyl)-1-nitrosourea	66-93	O-6-methylguanine-DNA methyltransferase	Homo sapiens	147-185
9351972-0	1997	Evidence for nucleotide excision repair as a modifying factor of O6-methylguanine-DNA methyltransferase-mediated innate chloroethylnitrosourea resistance in human tumor cell lines.	1-(2-chloroethyl)-1-nitrosourea	120-142	O-6-methylguanine-DNA methyltransferase	Homo sapiens	65-103
9351972-11	1997	The correlation of UV sensitivity with BCNU cytotoxicity suggests that nucleotide excision repair is an important modifying factor of MGMT-mediated innate CENU resistance in human tumor cell lines, especially in highly resistant cell lines.	1-(2-chloroethyl)-1-nitrosourea	155-159	O-6-methylguanine-DNA methyltransferase	Homo sapiens	134-138
9269990-0	1997	The DNA repair protein O6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineoplastic chloroethylnitrosourea.	1-(2-chloroethyl)-1-nitrosourea	126-148	O-6-methylguanine-DNA methyltransferase	Mus musculus	23-61
9269990-2	1997	Because secondary tumor formation is a serious threat in chemotherapy with these drugs, we explored whether and to what extent the DNA repair protein DNA-O6-methylguanine:protein-L-cysteine S-methyltransferase (MGMT) protects against CNU-induced tumors.	1-(2-chloroethyl)-1-nitrosourea	234-237	O-6-methylguanine-DNA methyltransferase	Mus musculus	150-209
9269990-2	1997	Because secondary tumor formation is a serious threat in chemotherapy with these drugs, we explored whether and to what extent the DNA repair protein DNA-O6-methylguanine:protein-L-cysteine S-methyltransferase (MGMT) protects against CNU-induced tumors.	1-(2-chloroethyl)-1-nitrosourea	234-237	O-6-methylguanine-DNA methyltransferase	Mus musculus	211-215
9269990-6	1997	The results provide clear evidence that MGMT exerts protection against CNU-induced cancer.	1-(2-chloroethyl)-1-nitrosourea	71-74	O-6-methylguanine-DNA methyltransferase	Mus musculus	40-44
9269990-7	1997	Our data also indicate that O6-chloroethylguanine, which is repaired by MGMT, is a main precarcinogenic CNU-induced DNA lesion.	1-(2-chloroethyl)-1-nitrosourea	104-107	O-6-methylguanine-DNA methyltransferase	Mus musculus	72-76
9148943-1	1997	The cytotoxic action of such alkylating chemotherapeutic drugs as 2-chloroethyl-N-nitrosourea (CNU) derivatives is countered by the repair protein O6-methylguanine-DNA methyltransferase (MGMT), which removes O6-alkylguanine induced in the DNA by these agents.	1-(2-chloroethyl)-1-nitrosourea	66-93	O-6-methylguanine-DNA methyltransferase	Homo sapiens	187-191
9148943-1	1997	The cytotoxic action of such alkylating chemotherapeutic drugs as 2-chloroethyl-N-nitrosourea (CNU) derivatives is countered by the repair protein O6-methylguanine-DNA methyltransferase (MGMT), which removes O6-alkylguanine induced in the DNA by these agents.	1-(2-chloroethyl)-1-nitrosourea	95-98	O-6-methylguanine-DNA methyltransferase	Homo sapiens	147-185
9148943-1	1997	The cytotoxic action of such alkylating chemotherapeutic drugs as 2-chloroethyl-N-nitrosourea (CNU) derivatives is countered by the repair protein O6-methylguanine-DNA methyltransferase (MGMT), which removes O6-alkylguanine induced in the DNA by these agents.	1-(2-chloroethyl)-1-nitrosourea	95-98	O-6-methylguanine-DNA methyltransferase	Homo sapiens	187-191
9148943-3	1997	Exposure of mouse 3T3 cells to increasing concentrations of CNU, and subsequent selection of resistant cells, led to the isolation of clones with 5-10 times higher levels of MGMT activity than in the control.	1-(2-chloroethyl)-1-nitrosourea	60-63	O-6-methylguanine-DNA methyltransferase	Mus musculus	174-178
9352585-2	1997	The ability of MGMT to also remove precytotoxic O6-alkylguanine lesions induced by chemotherapeutic chloroethylnitrosoureas has made down-regulation of MGMT expression the key component in strategies designed to sensitize tumors to the cytotoxic potential of chloroethylnitrosoureas.	1-(2-chloroethyl)-1-nitrosourea	100-123	O-6-methylguanine-DNA methyltransferase	Homo sapiens	15-19
8993023-3	1997	O6-Methylguanine DNA methyltransferase (MGMT) removes alkyl groups from the O6 position of guanine and has been shown to repair CNU-induced DNA damage.	1-(2-chloroethyl)-1-nitrosourea	128-131	O-6-methylguanine-DNA methyltransferase	Mus musculus	0-38
8993023-3	1997	O6-Methylguanine DNA methyltransferase (MGMT) removes alkyl groups from the O6 position of guanine and has been shown to repair CNU-induced DNA damage.	1-(2-chloroethyl)-1-nitrosourea	128-131	O-6-methylguanine-DNA methyltransferase	Mus musculus	40-44
8993023-4	1997	We have previously demonstrated that transplantation of murine bone marrow cells transduced with a recombinant retroviral vector expressing MGMT via the human phosphoglycerate kinase promoter (PGK-MGMT) protects animals in vivo from acute myelotoxicity associated with CNU treatment.	1-(2-chloroethyl)-1-nitrosourea	269-272	O-6-methylguanine-DNA methyltransferase	Mus musculus	140-144
8993023-4	1997	We have previously demonstrated that transplantation of murine bone marrow cells transduced with a recombinant retroviral vector expressing MGMT via the human phosphoglycerate kinase promoter (PGK-MGMT) protects animals in vivo from acute myelotoxicity associated with CNU treatment.	1-(2-chloroethyl)-1-nitrosourea	269-272	O-6-methylguanine-DNA methyltransferase	Homo sapiens	197-201
8993023-9	1997	Thus, long term immunodeficiency following CNU therapy may be prevented by genetic modification of murine hemopoietic stem cells with MGMT, leading to significant improvement in post-transplant immune function.	1-(2-chloroethyl)-1-nitrosourea	43-46	O-6-methylguanine-DNA methyltransferase	Mus musculus	134-138
9365163-1	1997	The exposure of cells to O6-benzyl-N2-acetylguanosine (BNAG) and several guanine derivatives is known to reduce the activity of O6-alkylguanine-DNA alkyltransferase (MGMT) and to enhance the sensitivity of Mer+ (methyl enzyme repair positive) tumour cells to chloroethylnitrosoureas (CENUs) in vitro and in vivo.	1-(2-chloroethyl)-1-nitrosourea	259-282	O-6-methylguanine-DNA methyltransferase	Homo sapiens	166-170
9352585-2	1997	The ability of MGMT to also remove precytotoxic O6-alkylguanine lesions induced by chemotherapeutic chloroethylnitrosoureas has made down-regulation of MGMT expression the key component in strategies designed to sensitize tumors to the cytotoxic potential of chloroethylnitrosoureas.	1-(2-chloroethyl)-1-nitrosourea	259-282	O-6-methylguanine-DNA methyltransferase	Homo sapiens	15-19
9352585-2	1997	The ability of MGMT to also remove precytotoxic O6-alkylguanine lesions induced by chemotherapeutic chloroethylnitrosoureas has made down-regulation of MGMT expression the key component in strategies designed to sensitize tumors to the cytotoxic potential of chloroethylnitrosoureas.	1-(2-chloroethyl)-1-nitrosourea	259-282	O-6-methylguanine-DNA methyltransferase	Homo sapiens	152-156
8900378-0	1996	Human brain tumor O(6)-methylguanine-DNA methyltransferase mRNA and its significance as an indicator of selective chloroethylnitrosourea chemotherapy.	1-(2-chloroethyl)-1-nitrosourea	114-136	O-6-methylguanine-DNA methyltransferase	Homo sapiens	18-58
8900378-1	1996	O(6)-methylguanine-DNA methyltransferase (MGMT) removes and repairs chloroethylnitrosourea (CENU)-induced O(6)-methylguanine-DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	68-90	O-6-methylguanine-DNA methyltransferase	Homo sapiens	0-40
8900378-1	1996	O(6)-methylguanine-DNA methyltransferase (MGMT) removes and repairs chloroethylnitrosourea (CENU)-induced O(6)-methylguanine-DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	92-96	O-6-methylguanine-DNA methyltransferase	Homo sapiens	0-40
8900378-1	1996	O(6)-methylguanine-DNA methyltransferase (MGMT) removes and repairs chloroethylnitrosourea (CENU)-induced O(6)-methylguanine-DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	92-96	O-6-methylguanine-DNA methyltransferase	Homo sapiens	42-46
8900378-1	1996	O(6)-methylguanine-DNA methyltransferase (MGMT) removes and repairs chloroethylnitrosourea (CENU)-induced O(6)-methylguanine-DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	68-90	O-6-methylguanine-DNA methyltransferase	Homo sapiens	42-46
8900378-2	1996	MGMT activity is, therefore, predictive of resistance or sensitivity to CENU chemotherapy.	1-(2-chloroethyl)-1-nitrosourea	72-76	O-6-methylguanine-DNA methyltransferase	Homo sapiens	0-4
7558444-1	1995	Activity of O6-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	113-136	O-6-methylguanine-DNA methyltransferase	Homo sapiens	12-50
8900378-7	1996	Out of 14 high-grade gliomas, 4 had a level of MGMT mRNA below 10%, indicating chemosensitivity to CENU.	1-(2-chloroethyl)-1-nitrosourea	99-103	O-6-methylguanine-DNA methyltransferase	Homo sapiens	47-51
8900378-11	1996	These results indicate that a fraction of brain tumors have a low expression of MGMT mRNA, and that the level of MGMT mRNA is a useful indicator of effectiveness in selective CENU chemotherapy.	1-(2-chloroethyl)-1-nitrosourea	175-179	O-6-methylguanine-DNA methyltransferase	Homo sapiens	113-117
8653679-0	1996	Correlation of chloroethylnitrosourea resistance with ERCC-2 expression in human tumor cell lines as determined by quantitative competitive polymerase chain reaction.	1-(2-chloroethyl)-1-nitrosourea	15-37	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	54-60
8616846-1	1996	High-level expression of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) correlates with cellular resistance to the chloroethylnitrosourea (CENU) class of alkylating agents.	1-(2-chloroethyl)-1-nitrosourea	137-159	O-6-methylguanine-DNA methyltransferase	Homo sapiens	48-86
8616846-1	1996	High-level expression of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) correlates with cellular resistance to the chloroethylnitrosourea (CENU) class of alkylating agents.	1-(2-chloroethyl)-1-nitrosourea	137-159	O-6-methylguanine-DNA methyltransferase	Homo sapiens	88-92
8616846-1	1996	High-level expression of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) correlates with cellular resistance to the chloroethylnitrosourea (CENU) class of alkylating agents.	1-(2-chloroethyl)-1-nitrosourea	161-165	O-6-methylguanine-DNA methyltransferase	Homo sapiens	48-86
8616846-1	1996	High-level expression of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) correlates with cellular resistance to the chloroethylnitrosourea (CENU) class of alkylating agents.	1-(2-chloroethyl)-1-nitrosourea	161-165	O-6-methylguanine-DNA methyltransferase	Homo sapiens	88-92
8616846-2	1996	Consequently, tumors expressing low levels of MGMT are sensitive to CENU chemotherapy, and any mechanism that can be used to reduce MGMT levels could sensitize resistant tumors.	1-(2-chloroethyl)-1-nitrosourea	68-72	O-6-methylguanine-DNA methyltransferase	Homo sapiens	46-50
8616846-2	1996	Consequently, tumors expressing low levels of MGMT are sensitive to CENU chemotherapy, and any mechanism that can be used to reduce MGMT levels could sensitize resistant tumors.	1-(2-chloroethyl)-1-nitrosourea	68-72	O-6-methylguanine-DNA methyltransferase	Homo sapiens	132-136
8616846-5	1996	Because p53 is inducible by ionizing radiation, we propose that existing cancer therapy regimens that combine radiotherapy with CENU chemotherapy may be improved by altering scheduling and allowing enough time between the two therapies for the relatively stable MGMT protein to degrade.	1-(2-chloroethyl)-1-nitrosourea	128-132	tumor protein p53	Homo sapiens	8-11
8605218-1	1996	O6-Methylguanine-DNA methyltransferase (MGMT) is strongly involved in drug resistance mechanism of tumor cells to chloroethylnitrosoureas (CENUs), because it removes and repairs CENU-induced O6-alkylguanine-DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	114-137	O-6-methylguanine-DNA methyltransferase	Homo sapiens	0-38
8605218-1	1996	O6-Methylguanine-DNA methyltransferase (MGMT) is strongly involved in drug resistance mechanism of tumor cells to chloroethylnitrosoureas (CENUs), because it removes and repairs CENU-induced O6-alkylguanine-DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	114-137	O-6-methylguanine-DNA methyltransferase	Homo sapiens	40-44
8605218-1	1996	O6-Methylguanine-DNA methyltransferase (MGMT) is strongly involved in drug resistance mechanism of tumor cells to chloroethylnitrosoureas (CENUs), because it removes and repairs CENU-induced O6-alkylguanine-DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	139-143	O-6-methylguanine-DNA methyltransferase	Homo sapiens	0-38
8605218-1	1996	O6-Methylguanine-DNA methyltransferase (MGMT) is strongly involved in drug resistance mechanism of tumor cells to chloroethylnitrosoureas (CENUs), because it removes and repairs CENU-induced O6-alkylguanine-DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	139-143	O-6-methylguanine-DNA methyltransferase	Homo sapiens	40-44
8552605-2	1996	Bone marrow CNU sensitivity is probably due to the inefficient repair of CNU-induced DNA damage; relative to other tissues, bone marrow cells express extremely low levels of the O6-methylguanine DNA methyltransferase (MGMT) protein that repairs cytotoxic O6-chloroethylguanine DNA lesions.	1-(2-chloroethyl)-1-nitrosourea	12-15	O-6-methylguanine-DNA methyltransferase	Mus musculus	178-216
8552605-2	1996	Bone marrow CNU sensitivity is probably due to the inefficient repair of CNU-induced DNA damage; relative to other tissues, bone marrow cells express extremely low levels of the O6-methylguanine DNA methyltransferase (MGMT) protein that repairs cytotoxic O6-chloroethylguanine DNA lesions.	1-(2-chloroethyl)-1-nitrosourea	12-15	O-6-methylguanine-DNA methyltransferase	Mus musculus	218-222
8552605-3	1996	Using a simplified recombinant retroviral vector expressing the human MGMT gene under control of the phosphoglycerate kinase promoter (PGK-MGMT) we increased the capacity of murine bone marrow-derived cells to repair CNU-induced DNA damage.	1-(2-chloroethyl)-1-nitrosourea	217-220	O-6-methylguanine-DNA methyltransferase	Homo sapiens	70-74
8552605-3	1996	Using a simplified recombinant retroviral vector expressing the human MGMT gene under control of the phosphoglycerate kinase promoter (PGK-MGMT) we increased the capacity of murine bone marrow-derived cells to repair CNU-induced DNA damage.	1-(2-chloroethyl)-1-nitrosourea	217-220	O-6-methylguanine-DNA methyltransferase	Homo sapiens	139-143
8552605-4	1996	Stable reconstitution of mouse bone marrow with genetically modified, MGMT-expressing hematopoietic stem cells conferred considerable resistance to the cytotoxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a CNU commonly used for chemotherapy.	1-(2-chloroethyl)-1-nitrosourea	212-215	O-6-methylguanine-DNA methyltransferase	Mus musculus	70-74
8632694-1	1996	O6-Alkylguanine derivatives sensitize tumor cells to chloroethylnitrosourea (CENU) chemotherapy by inactivation of O6-methylguanine-DNA methyltransferase (MGMT), which repairs CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	53-75	O-6-methylguanine-DNA methyltransferase	Homo sapiens	115-153
8632694-1	1996	O6-Alkylguanine derivatives sensitize tumor cells to chloroethylnitrosourea (CENU) chemotherapy by inactivation of O6-methylguanine-DNA methyltransferase (MGMT), which repairs CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	53-75	O-6-methylguanine-DNA methyltransferase	Homo sapiens	155-159
8632694-1	1996	O6-Alkylguanine derivatives sensitize tumor cells to chloroethylnitrosourea (CENU) chemotherapy by inactivation of O6-methylguanine-DNA methyltransferase (MGMT), which repairs CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	77-81	O-6-methylguanine-DNA methyltransferase	Homo sapiens	115-153
8632694-1	1996	O6-Alkylguanine derivatives sensitize tumor cells to chloroethylnitrosourea (CENU) chemotherapy by inactivation of O6-methylguanine-DNA methyltransferase (MGMT), which repairs CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	77-81	O-6-methylguanine-DNA methyltransferase	Homo sapiens	155-159
8632694-1	1996	O6-Alkylguanine derivatives sensitize tumor cells to chloroethylnitrosourea (CENU) chemotherapy by inactivation of O6-methylguanine-DNA methyltransferase (MGMT), which repairs CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	176-180	O-6-methylguanine-DNA methyltransferase	Homo sapiens	115-153
8632694-1	1996	O6-Alkylguanine derivatives sensitize tumor cells to chloroethylnitrosourea (CENU) chemotherapy by inactivation of O6-methylguanine-DNA methyltransferase (MGMT), which repairs CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	176-180	O-6-methylguanine-DNA methyltransferase	Homo sapiens	155-159
8761416-0	1996	Contribution of ogt-encoded alkyltransferase to resistance to chloroethylnitrosoureas in nucleotide excision repair-deficient Escherichia coli.	1-(2-chloroethyl)-1-nitrosourea	62-85	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	16-19
8645346-6	1996	In comparison with the control cells that were transduced with the parent vector, the MGMT-expressing clones were considerably more resistant to the cytotoxicity of the methylating agents, such as N-methyl-N"-nitro-N-nitrosoguanidine, N-nitroso-N-methyl-urea, and temozolomide, as well as the chloroethylating agents 1-(2-chloroethyl)-1-nitrosourea and BCNU.	1-(2-chloroethyl)-1-nitrosourea	317-348	O-6-methylguanine-DNA methyltransferase	Homo sapiens	86-90
7558444-1	1995	Activity of O6-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	113-136	O-6-methylguanine-DNA methyltransferase	Homo sapiens	52-56
7558444-1	1995	Activity of O6-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	113-136	O-6-methylguanine-DNA methyltransferase	Homo sapiens	154-158
7558444-1	1995	Activity of O6-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	138-142	O-6-methylguanine-DNA methyltransferase	Homo sapiens	12-50
7558444-1	1995	Activity of O6-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	138-142	O-6-methylguanine-DNA methyltransferase	Homo sapiens	52-56
7558444-1	1995	Activity of O6-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety.	1-(2-chloroethyl)-1-nitrosourea	138-142	O-6-methylguanine-DNA methyltransferase	Homo sapiens	154-158
7558444-11	1995	Potent MGMT inactivators (1-3, 5, 8, 9, 11) sensitize tumor cells to CENU chemotherapy.	1-(2-chloroethyl)-1-nitrosourea	69-73	O-6-methylguanine-DNA methyltransferase	Homo sapiens	7-11
7554086-1	1995	We have recently reported that following depletion of O6-methylguanine DNA methyltransferase (MGMT) activity by acute streptozotocin (STZ) treatment to sensitize innately chloroethylnitrosourea (CENU)-resistant HT-29 cells, the eventual repletion of activity occurs with no concommitant alterations in steady-state MGMT mRNA levels.	1-(2-chloroethyl)-1-nitrosourea	171-193	O-6-methylguanine-DNA methyltransferase	Homo sapiens	54-92
7554086-1	1995	We have recently reported that following depletion of O6-methylguanine DNA methyltransferase (MGMT) activity by acute streptozotocin (STZ) treatment to sensitize innately chloroethylnitrosourea (CENU)-resistant HT-29 cells, the eventual repletion of activity occurs with no concommitant alterations in steady-state MGMT mRNA levels.	1-(2-chloroethyl)-1-nitrosourea	171-193	O-6-methylguanine-DNA methyltransferase	Homo sapiens	94-98
7554086-1	1995	We have recently reported that following depletion of O6-methylguanine DNA methyltransferase (MGMT) activity by acute streptozotocin (STZ) treatment to sensitize innately chloroethylnitrosourea (CENU)-resistant HT-29 cells, the eventual repletion of activity occurs with no concommitant alterations in steady-state MGMT mRNA levels.	1-(2-chloroethyl)-1-nitrosourea	171-193	O-6-methylguanine-DNA methyltransferase	Homo sapiens	315-319
7554086-1	1995	We have recently reported that following depletion of O6-methylguanine DNA methyltransferase (MGMT) activity by acute streptozotocin (STZ) treatment to sensitize innately chloroethylnitrosourea (CENU)-resistant HT-29 cells, the eventual repletion of activity occurs with no concommitant alterations in steady-state MGMT mRNA levels.	1-(2-chloroethyl)-1-nitrosourea	195-199	O-6-methylguanine-DNA methyltransferase	Homo sapiens	54-92
7554086-1	1995	We have recently reported that following depletion of O6-methylguanine DNA methyltransferase (MGMT) activity by acute streptozotocin (STZ) treatment to sensitize innately chloroethylnitrosourea (CENU)-resistant HT-29 cells, the eventual repletion of activity occurs with no concommitant alterations in steady-state MGMT mRNA levels.	1-(2-chloroethyl)-1-nitrosourea	195-199	O-6-methylguanine-DNA methyltransferase	Homo sapiens	94-98
7554086-1	1995	We have recently reported that following depletion of O6-methylguanine DNA methyltransferase (MGMT) activity by acute streptozotocin (STZ) treatment to sensitize innately chloroethylnitrosourea (CENU)-resistant HT-29 cells, the eventual repletion of activity occurs with no concommitant alterations in steady-state MGMT mRNA levels.	1-(2-chloroethyl)-1-nitrosourea	195-199	O-6-methylguanine-DNA methyltransferase	Homo sapiens	315-319
7554090-1	1995	Previous studies have demonstrated that O6-methylguanine-DNA methyltransferase (MGMT) is a major contributor to tumor cellular resistance toward chloroethylnitrosoureas.	1-(2-chloroethyl)-1-nitrosourea	145-168	O-6-methylguanine-DNA methyltransferase	Homo sapiens	40-78
7554090-1	1995	Previous studies have demonstrated that O6-methylguanine-DNA methyltransferase (MGMT) is a major contributor to tumor cellular resistance toward chloroethylnitrosoureas.	1-(2-chloroethyl)-1-nitrosourea	145-168	O-6-methylguanine-DNA methyltransferase	Homo sapiens	80-84
7956741-1	1994	Tumor resistances to chloroethylnitrosourea (CENU) are mainly due to O6-alkylguanine-DNA alkyltransferase (AGT).	1-(2-chloroethyl)-1-nitrosourea	21-43	O-6-methylguanine-DNA methyltransferase	Mus musculus	69-105
7956741-1	1994	Tumor resistances to chloroethylnitrosourea (CENU) are mainly due to O6-alkylguanine-DNA alkyltransferase (AGT).	1-(2-chloroethyl)-1-nitrosourea	45-49	O-6-methylguanine-DNA methyltransferase	Mus musculus	69-105
8137253-10	1994	However, part of the chloroethylnitrosourea resistance in SKI-1 cells is not secondary to decreased accumulation.	1-(2-chloroethyl)-1-nitrosourea	21-43	membrane bound transcription factor peptidase, site 1	Homo sapiens	58-63
1727384-2	1992	We had previously shown that transfection of this plasmid into Chinese hamster ovary (CHO) cells results in the expression of MGMT and in increased cellular resistance to N-methyl-N"-nitro-N-nitrosoguanidine and 1-(2-chloroethyl)-1-nitrosourea (CNU) but not N-nitroso-N-ethylurea (ENU).	1-(2-chloroethyl)-1-nitrosourea	212-243	methylated-DNA--protein-cysteine methyltransferase	Cricetulus griseus	126-130
8145054-5	1993	As with chemosensitivity to chloroethylnitrosourea, O6-methylguanine-DNA methyltransferase (MGMT) activity was measured in in vitro cultured cells as well as tumor specimens obtained at surgery.	1-(2-chloroethyl)-1-nitrosourea	28-50	O-6-methylguanine-DNA methyltransferase	Homo sapiens	92-96
1518162-1	1992	Northern blot analysis with O6-methylguanine-DNA methyltransferase (MGMT) cDNA as a probe was used to analyze the MGMT activity regulating drug resistance of human cells to chloroethylnitrosoureas (CENUs).	1-(2-chloroethyl)-1-nitrosourea	173-196	O-6-methylguanine-DNA methyltransferase	Homo sapiens	28-66
1518162-1	1992	Northern blot analysis with O6-methylguanine-DNA methyltransferase (MGMT) cDNA as a probe was used to analyze the MGMT activity regulating drug resistance of human cells to chloroethylnitrosoureas (CENUs).	1-(2-chloroethyl)-1-nitrosourea	173-196	O-6-methylguanine-DNA methyltransferase	Homo sapiens	68-72
1518162-1	1992	Northern blot analysis with O6-methylguanine-DNA methyltransferase (MGMT) cDNA as a probe was used to analyze the MGMT activity regulating drug resistance of human cells to chloroethylnitrosoureas (CENUs).	1-(2-chloroethyl)-1-nitrosourea	173-196	O-6-methylguanine-DNA methyltransferase	Homo sapiens	114-118
8393842-0	1993	Influence of O6-methylguanine-DNA methyltransferase activity on chloroethylnitrosourea chemotherapy in brain tumors.	1-(2-chloroethyl)-1-nitrosourea	64-86	O-6-methylguanine-DNA methyltransferase	Homo sapiens	13-51
1394230-1	1992	Chloroethylnitrosoureas induce reactive O6-guanine adducts in DNA that can form either interstrand cross-links or a covalent complex with the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT).	1-(2-chloroethyl)-1-nitrosourea	0-23	O-6-methylguanine-DNA methyltransferase	Homo sapiens	161-199
1394230-1	1992	Chloroethylnitrosoureas induce reactive O6-guanine adducts in DNA that can form either interstrand cross-links or a covalent complex with the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT).	1-(2-chloroethyl)-1-nitrosourea	0-23	O-6-methylguanine-DNA methyltransferase	Homo sapiens	201-205
1531148-1	1992	BACKGROUND: Fewer than 20% of patients with nonhematologic malignancies treated with chloroethylnitrosoureas (CENUs) respond, but streptozocin (STZ), which depletes O6-methylguanine-DNA-methyltransferase (MGMT), has been shown to reverse resistance to CENUs in vitro.	1-(2-chloroethyl)-1-nitrosourea	85-108	O-6-methylguanine-DNA methyltransferase	Homo sapiens	205-209
1531148-1	1992	BACKGROUND: Fewer than 20% of patients with nonhematologic malignancies treated with chloroethylnitrosoureas (CENUs) respond, but streptozocin (STZ), which depletes O6-methylguanine-DNA-methyltransferase (MGMT), has been shown to reverse resistance to CENUs in vitro.	1-(2-chloroethyl)-1-nitrosourea	110-115	O-6-methylguanine-DNA methyltransferase	Homo sapiens	165-203
1531148-1	1992	BACKGROUND: Fewer than 20% of patients with nonhematologic malignancies treated with chloroethylnitrosoureas (CENUs) respond, but streptozocin (STZ), which depletes O6-methylguanine-DNA-methyltransferase (MGMT), has been shown to reverse resistance to CENUs in vitro.	1-(2-chloroethyl)-1-nitrosourea	110-115	O-6-methylguanine-DNA methyltransferase	Homo sapiens	205-209
1727384-2	1992	We had previously shown that transfection of this plasmid into Chinese hamster ovary (CHO) cells results in the expression of MGMT and in increased cellular resistance to N-methyl-N"-nitro-N-nitrosoguanidine and 1-(2-chloroethyl)-1-nitrosourea (CNU) but not N-nitroso-N-ethylurea (ENU).	1-(2-chloroethyl)-1-nitrosourea	245-248	methylated-DNA--protein-cysteine methyltransferase	Cricetulus griseus	126-130
1727384-6	1992	Expression of MGMT increased the resistance to CNU about 6-fold in both cell lines, but the difference between the two cell lines attributable to the excision repair defect still persisted.	1-(2-chloroethyl)-1-nitrosourea	47-50	methylated-DNA--protein-cysteine methyltransferase	Cricetulus griseus	14-18
1893534-2	1991	Similarly, the hypersensitivity to anticancer chloroethylnitrosoureas of some human tumor cell lines is believed to result from their deficiency in MGMT.	1-(2-chloroethyl)-1-nitrosourea	46-69	O-6-methylguanine-DNA methyltransferase	Homo sapiens	148-152
2052560-1	1991	Treatment of cultured human tumor cells with the chloroethylnitrosourea antitumor drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) selectively induces transcription and protein synthesis of a subset of the human heat shock or stress-induced genes (HSP90 and HSP70) with little effect on other stress genes or on expression of the c-fos, c-myc, or beta-actin genes.	1-(2-chloroethyl)-1-nitrosourea	49-71	heat shock protein 90 alpha family class A member 1	Homo sapiens	248-253
2052560-1	1991	Treatment of cultured human tumor cells with the chloroethylnitrosourea antitumor drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) selectively induces transcription and protein synthesis of a subset of the human heat shock or stress-induced genes (HSP90 and HSP70) with little effect on other stress genes or on expression of the c-fos, c-myc, or beta-actin genes.	1-(2-chloroethyl)-1-nitrosourea	49-71	heat shock protein family A (Hsp70) member 4	Homo sapiens	258-263
2052560-1	1991	Treatment of cultured human tumor cells with the chloroethylnitrosourea antitumor drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) selectively induces transcription and protein synthesis of a subset of the human heat shock or stress-induced genes (HSP90 and HSP70) with little effect on other stress genes or on expression of the c-fos, c-myc, or beta-actin genes.	1-(2-chloroethyl)-1-nitrosourea	49-71	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	330-335
2052560-1	1991	Treatment of cultured human tumor cells with the chloroethylnitrosourea antitumor drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) selectively induces transcription and protein synthesis of a subset of the human heat shock or stress-induced genes (HSP90 and HSP70) with little effect on other stress genes or on expression of the c-fos, c-myc, or beta-actin genes.	1-(2-chloroethyl)-1-nitrosourea	49-71	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	337-342
2052560-1	1991	Treatment of cultured human tumor cells with the chloroethylnitrosourea antitumor drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) selectively induces transcription and protein synthesis of a subset of the human heat shock or stress-induced genes (HSP90 and HSP70) with little effect on other stress genes or on expression of the c-fos, c-myc, or beta-actin genes.	1-(2-chloroethyl)-1-nitrosourea	49-71	POTE ankyrin domain family member F	Homo sapiens	347-357
1793486-2	1991	Transfection of this plasmid into Chinese hamster ovary (CHO) cells results in expression of MGMT and in cellular resistance to N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) and 1-(2-chloroethyl)-1-nitrosourea (CNU), but not to N-nitroso-N-ethylurea.	1-(2-chloroethyl)-1-nitrosourea	176-207	methylated-DNA--protein-cysteine methyltransferase	Cricetulus griseus	93-97
1664221-1	1991	O6-methylguanine-DNA methyltransferase (O6-MT) probably plays an important role in the repair of chloroethylnitrosourea-induced DNA damage.	1-(2-chloroethyl)-1-nitrosourea	97-119	O-6-methylguanine-DNA methyltransferase	Homo sapiens	0-38
1664221-1	1991	O6-methylguanine-DNA methyltransferase (O6-MT) probably plays an important role in the repair of chloroethylnitrosourea-induced DNA damage.	1-(2-chloroethyl)-1-nitrosourea	97-119	O-6-methylguanine-DNA methyltransferase	Homo sapiens	40-45
1825618-1	1991	Treatment of chloroethylnitrosourea-resistant cells with streptozotocin (STZ) prior to bis-chloroethylnitrosourea (BCNU) exposure has been shown to result in a depletion of O6-methylguanine DNA methyltransferase (MGMT) activity, increased BCNU-induced interstrand cross-linking, and a 2-3 log enhancement of BCNU cytotoxicity in vitro.	1-(2-chloroethyl)-1-nitrosourea	13-35	O-6-methylguanine-DNA methyltransferase	Homo sapiens	173-211
1825618-1	1991	Treatment of chloroethylnitrosourea-resistant cells with streptozotocin (STZ) prior to bis-chloroethylnitrosourea (BCNU) exposure has been shown to result in a depletion of O6-methylguanine DNA methyltransferase (MGMT) activity, increased BCNU-induced interstrand cross-linking, and a 2-3 log enhancement of BCNU cytotoxicity in vitro.	1-(2-chloroethyl)-1-nitrosourea	13-35	O-6-methylguanine-DNA methyltransferase	Homo sapiens	213-217
1793486-2	1991	Transfection of this plasmid into Chinese hamster ovary (CHO) cells results in expression of MGMT and in cellular resistance to N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) and 1-(2-chloroethyl)-1-nitrosourea (CNU), but not to N-nitroso-N-ethylurea.	1-(2-chloroethyl)-1-nitrosourea	209-212	methylated-DNA--protein-cysteine methyltransferase	Cricetulus griseus	93-97